﻿               SEQUENCE LISTING

<110> Max-Planck-Gesellschaft zur Foerderung der Wissenschaften e.V.
      Medizinische Universitaet Wien

<120> Methods for the detection of a latent tuberculosis infection

<130> Z1333 PCT S3

<160> 36

<170> BiSSAP 1.3

<210> 1
<211> 245
<212> DNA
<213> Mycobacterium tuberculosis

<220> 
<223> IS61110

<400> 1
cgtgagggca tcgaggtggc cagatgcacc gtcgaacggc tgatgaccaa actcggcctg     60

tccgggacca cccgcggcaa agcccgcagg accacgatcg ctgatccggc cacagcccgt    120

cccgccgatc tcgtccagcg ccgcttcgga ccaccagcac ctaaccggct gtgggtagca    180

gacctcacct atgtgtcgac ctgggcaggg ttcgcctacg tggcctttgt caccgacgcc    240

tacgc                                                                245


<210> 2
<211> 278
<212> PRT
<213> Mycobacterium tuberculosis

<220> 
<223> IS6110

<400> 2
Met Pro Ile Ala Pro Ser Thr Tyr Tyr Asp His Ile Asn Arg Glu Pro 
1               5                   10                  15      
Ser Arg Arg Glu Leu Arg Asp Gly Glu Leu Lys Glu His Ile Ser Arg 
            20                  25                  30          
Val His Ala Ala Asn Tyr Gly Val Tyr Gly Ala Arg Lys Val Trp Leu 
        35                  40                  45              
Thr Leu Asn Arg Glu Gly Ile Glu Val Ala Arg Cys Thr Val Glu Arg 
    50                  55                  60                  
Leu Met Thr Lys Leu Gly Leu Ser Gly Thr Thr Arg Gly Lys Ala Arg 
65                  70                  75                  80  
Arg Thr Thr Ile Ala Asp Pro Ala Thr Ala Arg Pro Ala Asp Leu Val 
                85                  90                  95      
Gln Arg Arg Phe Gly Pro Pro Ala Pro Asn Arg Leu Trp Val Ala Asp 
            100                 105                 110         
Leu Thr Tyr Val Ser Thr Trp Ala Gly Phe Ala Tyr Val Ala Phe Val 
        115                 120                 125             
Thr Asp Ala Tyr Ala Arg Arg Ile Leu Gly Trp Arg Val Ala Ser Thr 
    130                 135                 140                 
Met Ala Thr Ser Met Val Leu Asp Ala Ile Glu Gln Ala Ile Trp Thr 
145                 150                 155                 160 
Arg Gln Gln Glu Gly Val Leu Asp Leu Lys Asp Val Ile His His Thr 
                165                 170                 175     
Asp Arg Gly Ser Gln Tyr Thr Ser Ile Arg Phe Ser Glu Arg Leu Ala 
            180                 185                 190         
Glu Ala Gly Ile Gln Pro Ser Val Gly Ala Val Gly Ser Ser Tyr Asp 
        195                 200                 205             
Asn Ala Leu Ala Glu Thr Ile Asn Gly Leu Tyr Lys Thr Glu Leu Ile 
    210                 215                 220                 
Lys Pro Gly Lys Pro Trp Arg Ser Ile Glu Asp Val Glu Leu Ala Thr 
225                 230                 235                 240 
Ala Arg Trp Val Asp Trp Phe Asn His Arg Arg Leu Tyr Gln Tyr Cys 
                245                 250                 255     
Gly Asp Val Pro Pro Val Glu Leu Glu Ala Ala Tyr Tyr Ala Gln Arg 
            260                 265                 270         
Gln Arg Pro Ala Ala Gly 
        275             

<210> 3
<211> 687
<212> DNA
<213> Mycobacterium tuberculosis

<220> 
<223> MPB64

<400> 3
ggccagcatc gagtcgatcg cggaacgtgg gaccaatacc tgggttgggc cggctgcttc      60

gggcagcaac tcccccgggt tgaagaagaa aatcaccccg tcgttcgtga ctgcgaagtt     120

ctgataattc accgggtcca agccggcatt cggcgctatc gatacctgtt gtccggtctg     180

cttgctcagt tcaccttgca caatggggaa gacgactggc agcggatcgg tgtcagcctg     240

ccacagcgtg tcataggtga ttggcttgcg ataggcctgg tcccaatcga aggccttgta     300

cgtggtcgtt gggtgcgtgc cgccggcgtt ctggtagacc ttgagcacca cggcctgcgt     360

accacgcggc ggtatcgcgg actggtatgt ggccgaggtg atattcaatt cgtagggggc     420

ttcgcgtgga gtggacgatg tggccgcgct gaggaacttg tcgcgcgtct gggcgatgta     480

attttccagc gacttctggt cggggtagta actgggcagg ctgatgttga tgttgtaggc     540

cgggtcggac atttgaatct ggcacgcctg gccggtatcg gtgcctttca actcctcgca     600

gtaggtcttg ggcgcggccg tggccacacc cgaacaacag agcaaaacga cagccgtgac     660

cagcatgaag atcttgatgc gcacgtc                                         687


<210> 4
<211> 228
<212> PRT
<213> Mycobacterium tuberculosis

<400> 4
Val Arg Ile Lys Ile Phe Met Leu Val Thr Ala Val Val Leu Leu Cys 
1               5                   10                  15      
Cys Ser Gly Val Ala Thr Ala Ala Pro Lys Thr Tyr Cys Glu Glu Leu 
            20                  25                  30          
Lys Gly Thr Asp Thr Gly Gln Ala Cys Gln Ile Gln Met Ser Asp Pro 
        35                  40                  45              
Ala Tyr Asn Ile Asn Ile Ser Leu Pro Ser Tyr Tyr Pro Asp Gln Lys 
    50                  55                  60                  
Ser Leu Glu Asn Tyr Ile Ala Gln Thr Arg Asp Lys Phe Leu Ser Ala 
65                  70                  75                  80  
Ala Thr Ser Ser Thr Pro Arg Glu Ala Pro Tyr Glu Leu Asn Ile Thr 
                85                  90                  95      
Ser Ala Thr Tyr Gln Ser Ala Ile Pro Pro Arg Gly Thr Gln Ala Val 
            100                 105                 110         
Val Leu Lys Val Tyr Gln Asn Ala Gly Gly Thr His Pro Thr Thr Thr 
        115                 120                 125             
Tyr Lys Ala Phe Asp Trp Asp Gln Ala Tyr Arg Lys Pro Ile Thr Tyr 
    130                 135                 140                 
Asp Thr Leu Trp Gln Ala Asp Thr Asp Pro Leu Pro Val Val Phe Pro 
145                 150                 155                 160 
Ile Val Gln Gly Glu Leu Ser Lys Gln Thr Gly Gln Gln Val Ser Ile 
                165                 170                 175     
Ala Pro Asn Ala Gly Leu Asp Pro Val Asn Tyr Gln Asn Phe Ala Val 
            180                 185                 190         
Thr Asn Asp Gly Val Ile Phe Phe Phe Asn Pro Gly Glu Leu Leu Pro 
        195                 200                 205             
Glu Ala Ala Gly Pro Thr Gln Val Leu Val Pro Arg Ser Ala Ile Asp 
    210                 215                 220                 
Ser Met Leu Ala 
225             

<210> 5
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> IS6110 s

<400> 5
cgtgagggca tcgaggtggc                                                20


<210> 6
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> IS6110 as

<400> 6
gcgtaggcgt cggtgacaaa                                                20


<210> 7
<211> 18
<212> DNA
<213> Artificial Sequence

<220> 
<223> 1135-bp s

<400> 7
ccgtgacaac gaaactca                                                  18


<210> 8
<211> 18
<212> DNA
<213> Artificial Sequence

<220> 
<223> 1135-bp as

<400> 8
ccagtcctcg ctgtaggt                                                  18


<210> 9
<211> 18
<212> DNA
<213> Artificial Sequence

<220> 
<223> 969-bp s

<400> 9
atgaaggcaa acaccacg                                                  18


<210> 10
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> 969-bp as

<400> 10
gccgccaagg cagcagagca c                                              21


<210> 11
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> 2198-bp s

<400> 11
atctacttgc tcaccctaac g                                              21


<210> 12
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> 2198-bp s

<400> 12
gccgccaagg cagcagagca c                                              21


<210> 13
<211> 3519
<212> DNA
<213> Mycobacterium tuberculosis

<220> 
<223> gene: rpoB

<400> 13
ttggcagatt cccgccagag caaaacagcc gctagtccta gtccgagtcg cccgcaaagt       60

tcctcgaata actccgtacc cggagcgcca aaccgggtct ccttcgctaa gctgcgcgaa      120

ccacttgagg ttccgggact ccttgacgtc cagaccgatt cgttcgagtg gctgatcggt      180

tcgccgcgct ggcgcgaatc cgccgccgag cggggtgatg tcaacccagt gggtggcctg      240

gaagaggtgc tctacgagct gtctccgatc gaggacttct ccgggtcgat gtcgttgtcg      300

ttctctgacc ctcgtttcga cgatgtcaag gcacccgtcg acgagtgcaa agacaaggac      360

atgacgtacg cggctccact gttcgtcacc gccgagttca tcaacaacaa caccggtgag      420

atcaagagtc agacggtgtt catgggtgac ttcccgatga tgaccgagaa gggcacgttc      480

atcatcaacg ggaccgagcg tgtggtggtc agccagctgg tgcggtcgcc cggggtgtac      540

ttcgacgaga ccattgacaa gtccaccgac aagacgctgc acagcgtcaa ggtgatcccg      600

agccgcggcg cgtggctcga gtttgacgtc gacaagcgcg acaccgtcgg cgtgcgcatc      660

gaccgcaaac gccggcaacc ggtcaccgtg ctgctcaagg cgctgggctg gaccagcgag      720

cagattgtcg agcggttcgg gttctccgag atcatgcgat cgacgctgga gaaggacaac      780

accgtcggca ccgacgaggc gctgttggac atctaccgca agctgcgtcc gggcgagccc      840

ccgaccaaag agtcagcgca gacgctgttg gaaaacttgt tcttcaagga gaagcgctac      900

gacctggccc gcgtcggtcg ctataaggtc aacaagaagc tcgggctgca tgtcggcgag      960

cccatcacgt cgtcgacgct gaccgaagaa gacgtcgtgg ccaccatcga atatctggtc     1020

cgcttgcacg agggtcagac cacgatgacc gttccgggcg gcgtcgaggt gccggtggaa     1080

accgacgaca tcgaccactt cggcaaccgc cgcctgcgta cggtcggcga gctgatccaa     1140

aaccagatcc gggtcggcat gtcgcggatg gagcgggtgg tccgggagcg gatgaccacc     1200

caggacgtgg aggcgatcac accgcagacg ttgatcaaca tccggccggt ggtcgccgcg     1260

atcaaggagt tcttcggcac cagccagctg agccaattca tggaccagaa caacccgctg     1320

tcggggttga cccacaagcg ccgactgtcg gcgctggggc ccggcggtct gtcacgtgag     1380

cgtgccgggc tggaggtccg cgacgtgcac ccgtcgcact acggccggat gtgcccgatc     1440

gaaacccctg aggggcccaa catcggtctg atcggctcgc tgtcggtgta cgcgcgggtc     1500

aacccgttcg ggttcatcga aacgccgtac cgcaaggtgg tcgacggcgt ggttagcgac     1560

gagatcgtgt acctgaccgc cgacgaggag gaccgccacg tggtggcaca ggccaattcg     1620

ccgatcgatg cggacggtcg cttcgtcgag ccgcgcgtgc tggtccgccg caaggcgggc     1680

gaggtggagt acgtgccctc gtctgaggtg gactacatgg acgtctcgcc ccgccagatg     1740

gtgtcggtgg ccaccgcgat gattcccttc ctggagcacg acgacgccaa ccgtgccctc     1800

atgggggcaa acatgcagcg ccaggcggtg ccgctggtcc gtagcgaggc cccgctggtg     1860

ggcaccggga tggagctgcg cgcggcgatc gacgccggcg acgtcgtcgt cgccgaagaa     1920

agcggcgtca tcgaggaggt gtcggccgac tacatcactg tgatgcacga caacggcacc     1980

cggcgtacct accggatgcg caagtttgcc cggtccaacc acggcacttg cgccaaccag     2040

tgccccatcg tggacgcggg cgaccgagtc gaggccggtc aggtgatcgc cgacggtccc     2100

tgtactgacg acggcgagat ggcgctgggc aagaacctgc tggtggccat catgccgtgg     2160

gagggccaca actacgagga cgcgatcatc ctgtccaacc gcctggtcga agaggacgtg     2220

ctcacctcga tccacatcga ggagcatgag atcgatgctc gcgacaccaa gctgggtgcg     2280

gaggagatca cccgcgacat cccgaacatc tccgacgagg tgctcgccga cctggatgag     2340

cggggcatcg tgcgcatcgg tgccgaggtt cgcgacgggg acatcctggt cggcaaggtc     2400

accccgaagg gtgagaccga gctgacgccg gaggagcggc tgctgcgtgc catcttcggt     2460

gagaaggccc gcgaggtgcg cgacacttcg ctgaaggtgc cgcacggcga atccggcaag     2520

gtgatcggca ttcgggtgtt ttcccgcgag gacgaggacg agttgccggc cggtgtcaac     2580

gagctggtgc gtgtgtatgt ggctcagaaa cgcaagatct ccgacggtga caagctggcc     2640

ggccggcacg gcaacaaggg cgtgatcggc aagatcctgc cggttgagga catgccgttc     2700

cttgccgacg gcaccccggt ggacattatt ttgaacaccc acggcgtgcc gcgacggatg     2760

aacatcggcc agattttgga gacccacctg ggttggtgtg cccacagcgg ctggaaggtc     2820

gacgccgcca agggggttcc ggactgggcc gccaggctgc ccgacgaact gctcgaggcg     2880

cagccgaacg ccattgtgtc gacgccggtg ttcgacggcg cccaggaggc cgagctgcag     2940

ggcctgttgt cgtgcacgct gcccaaccgc gacggtgacg tgctggtcga cgccgacggc     3000

aaggccatgc tcttcgacgg gcgcagcggc gagccgttcc cgtacccggt cacggttggc     3060

tacatgtaca tcatgaagct gcaccacctg gtggacgaca agatccacgc ccgctccacc     3120

gggccgtact cgatgatcac ccagcagccg ctgggcggta aggcgcagtt cggtggccag     3180

cggttcgggg agatggagtg ctgggccatg caggcctacg gtgctgccta caccctgcag     3240

gagctgttga ccatcaagtc cgatgacacc gtcggccgcg tcaaggtgta cgaggcgatc     3300

gtcaagggtg agaacatccc ggagccgggc atccccgagt cgttcaaggt gctgctcaaa     3360

gaactgcagt cgctgtgcct caacgtcgag gtgctatcga gtgacggtgc ggcgatcgaa     3420

ctgcgcgaag gtgaggacga ggacctggag cgggccgcgg ccaacctggg aatcaatctg     3480

tcccgcaacg aatccgcaag tgtcgaggat cttgcgtaa                            3519


<210> 14
<211> 1178
<212> PRT
<213> Mycobacterium tuberculosis

<220> 
<223> RPOB

<400> 14
Met Leu Glu Gly Cys Ile Leu Ala Asp Ser Arg Gln Ser Lys Thr Ala 
1               5                   10                  15      
Ala Ser Pro Ser Pro Ser Arg Pro Gln Ser Ser Ser Asn Asn Ser Val 
            20                  25                  30          
Pro Gly Ala Pro Asn Arg Val Ser Phe Ala Lys Leu Arg Glu Pro Leu 
        35                  40                  45              
Glu Val Pro Gly Leu Leu Asp Val Gln Thr Asp Ser Phe Glu Trp Leu 
    50                  55                  60                  
Ile Gly Ser Pro Arg Trp Arg Glu Ser Ala Ala Glu Arg Gly Asp Val 
65                  70                  75                  80  
Asn Pro Val Gly Gly Leu Glu Glu Val Leu Tyr Glu Leu Ser Pro Ile 
                85                  90                  95      
Glu Asp Phe Ser Gly Ser Met Ser Leu Ser Phe Ser Asp Pro Arg Phe 
            100                 105                 110         
Asp Asp Val Lys Ala Pro Val Asp Glu Cys Lys Asp Lys Asp Met Thr 
        115                 120                 125             
Tyr Ala Ala Pro Leu Phe Val Thr Ala Glu Phe Ile Asn Asn Asn Thr 
    130                 135                 140                 
Gly Glu Ile Lys Ser Gln Thr Val Phe Met Gly Asp Phe Pro Met Met 
145                 150                 155                 160 
Thr Glu Lys Gly Thr Phe Ile Ile Asn Gly Thr Glu Arg Val Val Val 
                165                 170                 175     
Ser Gln Leu Val Arg Ser Pro Gly Val Tyr Phe Asp Glu Thr Ile Asp 
            180                 185                 190         
Lys Ser Thr Asp Lys Thr Leu His Ser Val Lys Val Ile Pro Ser Arg 
        195                 200                 205             
Gly Ala Trp Leu Glu Phe Asp Val Asp Lys Arg Asp Thr Val Gly Val 
    210                 215                 220                 
Arg Ile Asp Arg Lys Arg Arg Gln Pro Val Thr Val Leu Leu Lys Ala 
225                 230                 235                 240 
Leu Gly Trp Thr Ser Glu Gln Ile Val Glu Arg Phe Gly Phe Ser Glu 
                245                 250                 255     
Ile Met Arg Ser Thr Leu Glu Lys Asp Asn Thr Val Gly Thr Asp Glu 
            260                 265                 270         
Ala Leu Leu Asp Ile Tyr Arg Lys Leu Arg Pro Gly Glu Pro Pro Thr 
        275                 280                 285             
Lys Glu Ser Ala Gln Thr Leu Leu Glu Asn Leu Phe Phe Lys Glu Lys 
    290                 295                 300                 
Arg Tyr Asp Leu Ala Arg Val Gly Arg Tyr Lys Val Asn Lys Lys Leu 
305                 310                 315                 320 
Gly Leu His Val Gly Glu Pro Ile Thr Ser Ser Thr Leu Thr Glu Glu 
                325                 330                 335     
Asp Val Val Ala Thr Ile Glu Tyr Leu Val Arg Leu His Glu Gly Gln 
            340                 345                 350         
Thr Thr Met Thr Val Pro Gly Gly Val Glu Val Pro Val Glu Thr Asp 
        355                 360                 365             
Asp Ile Asp His Phe Gly Asn Arg Arg Leu Arg Thr Val Gly Glu Leu 
    370                 375                 380                 
Ile Gln Asn Gln Ile Arg Val Gly Met Ser Arg Met Glu Arg Val Val 
385                 390                 395                 400 
Arg Glu Arg Met Thr Thr Gln Asp Val Glu Ala Ile Thr Pro Gln Thr 
                405                 410                 415     
Leu Ile Asn Ile Arg Pro Val Val Ala Ala Ile Lys Glu Phe Phe Gly 
            420                 425                 430         
Thr Ser Gln Leu Ser Gln Phe Met Asp Gln Asn Asn Pro Leu Ser Gly 
        435                 440                 445             
Leu Thr His Lys Arg Arg Leu Ser Ala Leu Gly Pro Gly Gly Leu Ser 
    450                 455                 460                 
Arg Glu Arg Ala Gly Leu Glu Val Arg Asp Val His Pro Ser His Tyr 
465                 470                 475                 480 
Gly Arg Met Cys Pro Ile Glu Thr Pro Glu Gly Pro Asn Ile Gly Leu 
                485                 490                 495     
Ile Gly Ser Leu Ser Val Tyr Ala Arg Val Asn Pro Phe Gly Phe Ile 
            500                 505                 510         
Glu Thr Pro Tyr Arg Lys Val Val Asp Gly Val Val Ser Asp Glu Ile 
        515                 520                 525             
Val Tyr Leu Thr Ala Asp Glu Glu Asp Arg His Val Val Ala Gln Ala 
    530                 535                 540                 
Asn Ser Pro Ile Asp Ala Asp Gly Arg Phe Val Glu Pro Arg Val Leu 
545                 550                 555                 560 
Val Arg Arg Lys Ala Gly Glu Val Glu Tyr Val Pro Ser Ser Glu Val 
                565                 570                 575     
Asp Tyr Met Asp Val Ser Pro Arg Gln Met Val Ser Val Ala Thr Ala 
            580                 585                 590         
Met Ile Pro Phe Leu Glu His Asp Asp Ala Asn Arg Ala Leu Met Gly 
        595                 600                 605             
Ala Asn Met Gln Arg Gln Ala Val Pro Leu Val Arg Ser Glu Ala Pro 
    610                 615                 620                 
Leu Val Gly Thr Gly Met Glu Leu Arg Ala Ala Ile Asp Ala Gly Asp 
625                 630                 635                 640 
Val Val Val Ala Glu Glu Ser Gly Val Ile Glu Glu Val Ser Ala Asp 
                645                 650                 655     
Tyr Ile Thr Val Met His Asp Asn Gly Thr Arg Arg Thr Tyr Arg Met 
            660                 665                 670         
Arg Lys Phe Ala Arg Ser Asn His Gly Thr Cys Ala Asn Gln Cys Pro 
        675                 680                 685             
Ile Val Asp Ala Gly Asp Arg Val Glu Ala Gly Gln Val Ile Ala Asp 
    690                 695                 700                 
Gly Pro Cys Thr Asp Asp Gly Glu Met Ala Leu Gly Lys Asn Leu Leu 
705                 710                 715                 720 
Val Ala Ile Met Pro Trp Glu Gly His Asn Tyr Glu Asp Ala Ile Ile 
                725                 730                 735     
Leu Ser Asn Arg Leu Val Glu Glu Asp Val Leu Thr Ser Ile His Ile 
            740                 745                 750         
Glu Glu His Glu Ile Asp Ala Arg Asp Thr Lys Leu Gly Ala Glu Glu 
        755                 760                 765             
Ile Thr Arg Asp Ile Pro Asn Ile Ser Asp Glu Val Leu Ala Asp Leu 
    770                 775                 780                 
Asp Glu Arg Gly Ile Val Arg Ile Gly Ala Glu Val Arg Asp Gly Asp 
785                 790                 795                 800 
Ile Leu Val Gly Lys Val Thr Pro Lys Gly Glu Thr Glu Leu Thr Pro 
                805                 810                 815     
Glu Glu Arg Leu Leu Arg Ala Ile Phe Gly Glu Lys Ala Arg Glu Val 
            820                 825                 830         
Arg Asp Thr Ser Leu Lys Val Pro His Gly Glu Ser Gly Lys Val Ile 
        835                 840                 845             
Gly Ile Arg Val Phe Ser Arg Glu Asp Glu Asp Glu Leu Pro Ala Gly 
    850                 855                 860                 
Val Asn Glu Leu Val Arg Val Tyr Val Ala Gln Lys Arg Lys Ile Ser 
865                 870                 875                 880 
Asp Gly Asp Lys Leu Ala Gly Arg His Gly Asn Lys Gly Val Ile Gly 
                885                 890                 895     
Lys Ile Leu Pro Val Glu Asp Met Pro Phe Leu Ala Asp Gly Thr Pro 
            900                 905                 910         
Val Asp Ile Ile Leu Asn Thr His Gly Val Pro Arg Arg Met Asn Ile 
        915                 920                 925             
Gly Gln Ile Leu Glu Thr His Leu Gly Trp Cys Ala His Ser Gly Trp 
    930                 935                 940                 
Lys Val Asp Ala Ala Lys Gly Val Pro Asp Trp Ala Ala Arg Leu Pro 
945                 950                 955                 960 
Asp Glu Leu Leu Glu Ala Gln Pro Asn Ala Ile Val Ser Thr Pro Val 
                965                 970                 975     
Phe Asp Gly Ala Gln Glu Ala Glu Leu Gln Gly Leu Leu Ser Cys Thr 
            980                 985                 990         
Leu Pro Asn Arg Asp Gly Asp Val Leu Val Asp Ala Asp Gly Lys Ala 
        995                 1000                1005            
Met Leu Phe Asp Gly Arg Ser Gly Glu Pro Phe Pro Tyr Pro Val Thr 
    1010                1015                1020                
Val Gly Tyr Met Tyr Ile Met Lys Leu His His Leu Val Asp Asp Lys 
1025                1030                1035                1040
Ile His Ala Arg Ser Thr Gly Pro Tyr Ser Met Ile Thr Gln Gln Pro 
                1045                1050                1055    
Leu Gly Gly Lys Ala Gln Phe Gly Gly Gln Arg Phe Gly Glu Met Glu 
            1060                1065                1070        
Cys Trp Ala Met Gln Ala Tyr Gly Ala Ala Tyr Thr Leu Gln Glu Leu 
        1075                1080                1085            
Leu Thr Ile Lys Ser Asp Asp Thr Val Gly Arg Val Lys Val Tyr Glu 
    1090                1095                1100                
Ala Ile Val Lys Gly Glu Asn Ile Pro Glu Pro Gly Ile Pro Glu Ser 
1105                1110                1115                1120
Phe Lys Val Leu Leu Lys Glu Leu Gln Ser Leu Cys Leu Asn Val Glu 
                1125                1130                1135    
Val Leu Ser Ser Asp Gly Ala Ala Ile Glu Leu Arg Glu Gly Glu Asp 
            1140                1145                1150        
Glu Asp Leu Glu Arg Ala Ala Ala Asn Leu Gly Ile Asn Leu Ser Arg 
        1155                1160                1165            
Asn Glu Ser Ala Ser Val Glu Asp Leu Ala 
    1170                1175            

<210> 15
<211> 2028
<212> DNA
<213> Mycobacterium tuberculosis

<220> 
<223> Gene: gyrB (Rv0005)

<400> 15
gtggctgccc agaaaaagaa ggcccaagac gaatacggcg ctgcgtctat caccattctc      60

gaagggctgg aggccgtccg caaacgtccc ggcatgtaca ttggctcgac cggtgagcgc     120

ggtttacacc atctcatttg ggaggtggtc gacaacgcgg tcgacgaggc gatggccggt     180

tatgcaacca cagtgaacgt agtgctgctt gaggatggcg gtgtcgaggt cgccgacgac     240

ggccgcggca ttccggtcgc cacccacgcc tccggcatac cgaccgtcga cgtggtgatg     300

acacaactac atgccggcgg caagttcgac tcggacgcgt atgcgatatc tggtggtctg     360

cacggcgtcg gcgtgtcggt ggttaacgcg ctatccaccc ggctcgaagt cgagatcaag     420

cgcgacgggt acgagtggtc tcaggtttat gagaagtcgg aacccctggg cctcaagcaa     480

ggggcgccga ccaagaagac ggggtcaacg gtgcggttct gggccgaccc cgctgttttc     540

gaaaccacgg aatacgactt cgaaaccgtc gcccgccggc tgcaagagat ggcgttcctc     600

aacaaggggc tgaccatcaa cctgaccgac gagagggtga cccaagacga ggtcgtcgac     660

gaagtggtca gcgacgtcgc cgaggcgccg aagtcggcaa gtgaacgcgc agccgaatcc     720

actgcaccgc acaaagttaa gagccgcacc tttcactatc cgggtggcct ggtggacttc     780

gtgaaacaca tcaaccgcac caagaacgcg attcatagca gcatcgtgga cttttccggc     840

aagggcaccg ggcacgaggt ggagatcgcg atgcaatgga acgccgggta ttcggagtcg     900

gtgcacacct tcgccaacac catcaacacc cacgagggcg gcacccacga agagggcttc     960

cgcagcgcgc tgacgtcggt ggtgaacaag tacgccaagg accgcaagct actgaaggac    1020

aaggacccca acctcaccgg tgacgatatc cgggaaggcc tggccgctgt gatctcggtg    1080

aaggtcagcg aaccgcagtt cgagggccag accaagacca agttgggcaa caccgaggtc    1140

aaatcgtttg tgcagaaggt ctgtaacgaa cagctgaccc actggtttga agccaacccc    1200

accgacgcga aagtcgttgt gaacaaggct gtgtcctcgg cgcaagcccg tatcgcggca    1260

cgtaaggcac gagagttggt gcggcgtaag agcgccaccg acatcggtgg attgcccggc    1320

aagctggccg attgccgttc cacggatccg cgcaagtccg aactgtatgt cgtagaaggt    1380

gactcggccg gcggttctgc aaaaagcggt cgcgattcga tgttccaggc gatacttccg    1440

ctgcgcggca agatcatcaa tgtggagaaa gcgcgcatcg accgggtgct aaagaacacc    1500

gaagttcagg cgatcatcac ggcgctgggc accgggatcc acgacgagtt cgatatcggc    1560

aagctgcgct accacaagat cgtgctgatg gccgacgccg atgttgacgg ccaacatatt    1620

tccacgctgt tgttgacgtt gttgttccgg ttcatgcggc cgctcatcga gaacgggcat    1680

gtgtttttgg cacaaccgcc gctgtacaaa ctcaagtggc agcgcagtga cccggaattc    1740

gcatactccg accgcgagcg cgacggtctg ctggaggcgg ggctgaaggc cgggaagaag    1800

atcaacaagg aagacggcat tcagcggtac aagggtctag gtgaaatgga cgctaaggag    1860

ttgtgggaga ccaccatgga tccctcggtt cgtgtgttgc gtcaagtgac gctggacgac    1920

gccgccgccg ccgacgagtt gttctccatc ctgatgggcg aggacgtcga cgcgcggcgc    1980

agctttatca cccgcaacgc caaggatgtt cggttcctgg atgtctaa                 2028


<210> 16
<211> 675
<212> PRT
<213> Mycobacterium tuberculosis

<400> 16
Met Ala Ala Gln Lys Lys Lys Ala Gln Asp Glu Tyr Gly Ala Ala Ser 
1               5                   10                  15      
Ile Thr Ile Leu Glu Gly Leu Glu Ala Val Arg Lys Arg Pro Gly Met 
            20                  25                  30          
Tyr Ile Gly Ser Thr Gly Glu Arg Gly Leu His His Leu Ile Trp Glu 
        35                  40                  45              
Val Val Asp Asn Ala Val Asp Glu Ala Met Ala Gly Tyr Ala Thr Thr 
    50                  55                  60                  
Val Asn Val Val Leu Leu Glu Asp Gly Gly Val Glu Val Ala Asp Asp 
65                  70                  75                  80  
Gly Arg Gly Ile Pro Val Ala Thr His Ala Ser Gly Ile Pro Thr Val 
                85                  90                  95      
Asp Val Val Met Thr Gln Leu His Ala Gly Gly Lys Phe Asp Ser Asp 
            100                 105                 110         
Ala Tyr Ala Ile Ser Gly Gly Leu His Gly Val Gly Val Ser Val Val 
        115                 120                 125             
Asn Ala Leu Ser Thr Arg Leu Glu Val Glu Ile Lys Arg Asp Gly Tyr 
    130                 135                 140                 
Glu Trp Ser Gln Val Tyr Glu Lys Ser Glu Pro Leu Gly Leu Lys Gln 
145                 150                 155                 160 
Gly Ala Pro Thr Lys Lys Thr Gly Ser Thr Val Arg Phe Trp Ala Asp 
                165                 170                 175     
Pro Ala Val Phe Glu Thr Thr Glu Tyr Asp Phe Glu Thr Val Ala Arg 
            180                 185                 190         
Arg Leu Gln Glu Met Ala Phe Leu Asn Lys Gly Leu Thr Ile Asn Leu 
        195                 200                 205             
Thr Asp Glu Arg Val Thr Gln Asp Glu Val Val Asp Glu Val Val Ser 
    210                 215                 220                 
Asp Val Ala Glu Ala Pro Lys Ser Ala Ser Glu Arg Ala Ala Glu Ser 
225                 230                 235                 240 
Thr Ala Pro His Lys Val Lys Ser Arg Thr Phe His Tyr Pro Gly Gly 
                245                 250                 255     
Leu Val Asp Phe Val Lys His Ile Asn Arg Thr Lys Asn Ala Ile His 
            260                 265                 270         
Ser Ser Ile Val Asp Phe Ser Gly Lys Gly Thr Gly His Glu Val Glu 
        275                 280                 285             
Ile Ala Met Gln Trp Asn Ala Gly Tyr Ser Glu Ser Val His Thr Phe 
    290                 295                 300                 
Ala Asn Thr Ile Asn Thr His Glu Gly Gly Thr His Glu Glu Gly Phe 
305                 310                 315                 320 
Arg Ser Ala Leu Thr Ser Val Val Asn Lys Tyr Ala Lys Asp Arg Lys 
                325                 330                 335     
Leu Leu Lys Asp Lys Asp Pro Asn Leu Thr Gly Asp Asp Ile Arg Glu 
            340                 345                 350         
Gly Leu Ala Ala Val Ile Ser Val Lys Val Ser Glu Pro Gln Phe Glu 
        355                 360                 365             
Gly Gln Thr Lys Thr Lys Leu Gly Asn Thr Glu Val Lys Ser Phe Val 
    370                 375                 380                 
Gln Lys Val Cys Asn Glu Gln Leu Thr His Trp Phe Glu Ala Asn Pro 
385                 390                 395                 400 
Thr Asp Ala Lys Val Val Val Asn Lys Ala Val Ser Ser Ala Gln Ala 
                405                 410                 415     
Arg Ile Ala Ala Arg Lys Ala Arg Glu Leu Val Arg Arg Lys Ser Ala 
            420                 425                 430         
Thr Asp Ile Gly Gly Leu Pro Gly Lys Leu Ala Asp Cys Arg Ser Thr 
        435                 440                 445             
Asp Pro Arg Lys Ser Glu Leu Tyr Val Val Glu Gly Asp Ser Ala Gly 
    450                 455                 460                 
Gly Ser Ala Lys Ser Gly Arg Asp Ser Met Phe Gln Ala Ile Leu Pro 
465                 470                 475                 480 
Leu Arg Gly Lys Ile Ile Asn Val Glu Lys Ala Arg Ile Asp Arg Val 
                485                 490                 495     
Leu Lys Asn Thr Glu Val Gln Ala Ile Ile Thr Ala Leu Gly Thr Gly 
            500                 505                 510         
Ile His Asp Glu Phe Asp Ile Gly Lys Leu Arg Tyr His Lys Ile Val 
        515                 520                 525             
Leu Met Ala Asp Ala Asp Val Asp Gly Gln His Ile Ser Thr Leu Leu 
    530                 535                 540                 
Leu Thr Leu Leu Phe Arg Phe Met Arg Pro Leu Ile Glu Asn Gly His 
545                 550                 555                 560 
Val Phe Leu Ala Gln Pro Pro Leu Tyr Lys Leu Lys Trp Gln Arg Ser 
                565                 570                 575     
Asp Pro Glu Phe Ala Tyr Ser Asp Arg Glu Arg Asp Gly Leu Leu Glu 
            580                 585                 590         
Ala Gly Leu Lys Ala Gly Lys Lys Ile Asn Lys Glu Asp Gly Ile Gln 
        595                 600                 605             
Arg Tyr Lys Gly Leu Gly Glu Met Asp Ala Lys Glu Leu Trp Glu Thr 
    610                 615                 620                 
Thr Met Asp Pro Ser Val Arg Val Leu Arg Gln Val Thr Leu Asp Asp 
625                 630                 635                 640 
Ala Ala Ala Ala Asp Glu Leu Phe Ser Ile Leu Met Gly Glu Asp Val 
                645                 650                 655     
Asp Ala Arg Arg Ser Phe Ile Thr Arg Asn Ala Lys Asp Val Arg Phe 
            660                 665                 670         
Leu Asp Val 
        675 

<210> 17
<211> 2517
<212> DNA
<213> Mycobacterium tuberculosis

<220> 
<223> Gene: gyrA (Rv0006)

<400> 17
atgacagaca cgacgttgcc gcctgacgac tcgctcgacc ggatcgaacc ggttgacatc      60

gagcaggaga tgcagcgcag ctacatcgac tatgcgatga gcgtgatcgt cggccgcgcg     120

ctgccggagg tgcgcgacgg gctcaagccc gtgcatcgcc gggtgctcta tgcaatgttc     180

gattccggct tccgcccgga ccgcagccac gccaagtcgg cccggtcggt tgccgagacc     240

atgggcaact accacccgca cggcgacgcg tcgatctacg acagcctggt gcgcatggcc     300

cagccctggt cgctgcgcta cccgctggtg gacggccagg gcaacttcgg ctcgccaggc     360

aatgacccac cggcggcgat gaggtacacc gaagcccggc tgaccccgtt ggcgatggag     420

atgctgaggg aaatcgacga ggagacagtc gatttcatcc ctaactacga cggccgggtg     480

caagagccga cggtgctacc cagccggttc cccaacctgc tggccaacgg gtcaggcggc     540

atcgcggtcg gcatggcaac caatatcccg ccgcacaacc tgcgtgagct ggccgacgcg     600

gtgttctggg cgctggagaa tcacgacgcc gacgaagagg agaccctggc cgcggtcatg     660

gggcgggtta aaggcccgga cttcccgacc gccggactga tcgtcggatc ccagggcacc     720

gctgatgcct acaaaactgg ccgcggctcc attcgaatgc gcggagttgt tgaggtagaa     780

gaggattccc gcggtcgtac ctcgctggtg atcaccgagt tgccgtatca ggtcaaccac     840

gacaacttca tcacttcgat cgccgaacag gtccgagacg gcaagctggc cggcatttcc     900

aacattgagg accagtctag cgatcgggtc ggtttacgca tcgtcatcga gatcaagcgc     960

gatgcggtgg ccaaggtggt gatcaataac ctttacaagc acacccagct gcagaccagc    1020

tttggcgcca acatgctagc gatcgtcgac ggggtgccgc gcacgctgcg gctggaccag    1080

ctgatccgct attacgttga ccaccaactc gacgtcattg tgcggcgcac cacctaccgg    1140

ctgcgcaagg caaacgagcg agcccacatt ctgcgcggcc tggttaaagc gctcgacgcg    1200

ctggacgagg tcattgcact gatccgggcg tcggagaccg tcgatatcgc ccgggccgga    1260

ctgatcgagc tgctcgacat cgacgagatc caggcccagg caatcctgga catgcagttg    1320

cggcgcctgg ccgcactgga acgccagcgc atcatcgacg acctggccaa aatcgaggcc    1380

gagatcgccg atctggaaga catcctggca aaacccgagc ggcagcgtgg gatcgtgcgc    1440

gacgaactcg ccgaaatcgt ggacaggcac ggcgacgacc ggcgtacccg gatcatcgcg    1500

gccgacggag acgtcagcga cgaggatttg atcgcccgcg aggacgtcgt tgtcactatc    1560

accgaaacgg gatacgccaa gcgcaccaag accgatctgt atcgcagcca gaaacgcggc    1620

ggcaagggcg tgcagggtgc ggggttgaag caggacgaca tcgtcgcgca cttcttcgtg    1680

tgctccaccc acgatttgat cctgttcttc accacccagg gacgggttta tcgggccaag    1740

gcctacgact tgcccgaggc ctcccggacg gcgcgcgggc agcacgtggc caacctgtta    1800

gccttccagc ccgaggaacg catcgcccag gtcatccaga ttcgcggcta caccgacgcc    1860

ccgtacctgg tgctggccac tcgcaacggg ctggtgaaaa agtccaagct gaccgacttc    1920

gactccaatc gctcgggcgg aatcgtggcg gtcaacctgc gcgacaacga cgagctggtc    1980

ggtgcggtgc tgtgttcggc cggcgacgac ctgctgctgg tctcggccaa cgggcagtcc    2040

atcaggttct cggcgaccga cgaggcgctg cggccaatgg gtcgtgccac ctcgggtgtg    2100

cagggcatgc ggttcaatat cgacgaccgg ctgctgtcgc tgaacgtcgt gcgtgaaggc    2160

acctatctgc tggtggcgac gtcagggggc tatgcgaaac gtaccgcgat cgaggaatac    2220

ccggtacagg gccgcggcgg taaaggtgtg ctgacggtca tgtacgaccg ccggcgcggc    2280

aggttggttg gggcgttgat tgtcgacgac gacagcgagc tgtatgccgt cacttccggc    2340

ggtggcgtga tccgcaccgc ggcacgccag gttcgcaagg cgggacggca gaccaagggt    2400

gttcggttga tgaatctggg cgagggcgac acactgttgg ccatcgcgcg caacgccgaa    2460

gaaagtggcg acgataatgc cgtggacgcc aacggcgcag accagacggg caattaa       2517


<210> 18
<211> 838
<212> PRT
<213> Mycobacterium tuberculosis

<400> 18
Met Thr Asp Thr Thr Leu Pro Pro Asp Asp Ser Leu Asp Arg Ile Glu 
1               5                   10                  15      
Pro Val Asp Ile Glu Gln Glu Met Gln Arg Ser Tyr Ile Asp Tyr Ala 
            20                  25                  30          
Met Ser Val Ile Val Gly Arg Ala Leu Pro Glu Val Arg Asp Gly Leu 
        35                  40                  45              
Lys Pro Val His Arg Arg Val Leu Tyr Ala Met Phe Asp Ser Gly Phe 
    50                  55                  60                  
Arg Pro Asp Arg Ser His Ala Lys Ser Ala Arg Ser Val Ala Glu Thr 
65                  70                  75                  80  
Met Gly Asn Tyr His Pro His Gly Asp Ala Ser Ile Tyr Asp Ser Leu 
                85                  90                  95      
Val Arg Met Ala Gln Pro Trp Ser Leu Arg Tyr Pro Leu Val Asp Gly 
            100                 105                 110         
Gln Gly Asn Phe Gly Ser Pro Gly Asn Asp Pro Pro Ala Ala Met Arg 
        115                 120                 125             
Tyr Thr Glu Ala Arg Leu Thr Pro Leu Ala Met Glu Met Leu Arg Glu 
    130                 135                 140                 
Ile Asp Glu Glu Thr Val Asp Phe Ile Pro Asn Tyr Asp Gly Arg Val 
145                 150                 155                 160 
Gln Glu Pro Thr Val Leu Pro Ser Arg Phe Pro Asn Leu Leu Ala Asn 
                165                 170                 175     
Gly Ser Gly Gly Ile Ala Val Gly Met Ala Thr Asn Ile Pro Pro His 
            180                 185                 190         
Asn Leu Arg Glu Leu Ala Asp Ala Val Phe Trp Ala Leu Glu Asn His 
        195                 200                 205             
Asp Ala Asp Glu Glu Glu Thr Leu Ala Ala Val Met Gly Arg Val Lys 
    210                 215                 220                 
Gly Pro Asp Phe Pro Thr Ala Gly Leu Ile Val Gly Ser Gln Gly Thr 
225                 230                 235                 240 
Ala Asp Ala Tyr Lys Thr Gly Arg Gly Ser Ile Arg Met Arg Gly Val 
                245                 250                 255     
Val Glu Val Glu Glu Asp Ser Arg Gly Arg Thr Ser Leu Val Ile Thr 
            260                 265                 270         
Glu Leu Pro Tyr Gln Val Asn His Asp Asn Phe Ile Thr Ser Ile Ala 
        275                 280                 285             
Glu Gln Val Arg Asp Gly Lys Leu Ala Gly Ile Ser Asn Ile Glu Asp 
    290                 295                 300                 
Gln Ser Ser Asp Arg Val Gly Leu Arg Ile Val Ile Glu Ile Lys Arg 
305                 310                 315                 320 
Asp Ala Val Ala Lys Val Val Ile Asn Asn Leu Tyr Lys His Thr Gln 
                325                 330                 335     
Leu Gln Thr Ser Phe Gly Ala Asn Met Leu Ala Ile Val Asp Gly Val 
            340                 345                 350         
Pro Arg Thr Leu Arg Leu Asp Gln Leu Ile Arg Tyr Tyr Val Asp His 
        355                 360                 365             
Gln Leu Asp Val Ile Val Arg Arg Thr Thr Tyr Arg Leu Arg Lys Ala 
    370                 375                 380                 
Asn Glu Arg Ala His Ile Leu Arg Gly Leu Val Lys Ala Leu Asp Ala 
385                 390                 395                 400 
Leu Asp Glu Val Ile Ala Leu Ile Arg Ala Ser Glu Thr Val Asp Ile 
                405                 410                 415     
Ala Arg Ala Gly Leu Ile Glu Leu Leu Asp Ile Asp Glu Ile Gln Ala 
            420                 425                 430         
Gln Ala Ile Leu Asp Met Gln Leu Arg Arg Leu Ala Ala Leu Glu Arg 
        435                 440                 445             
Gln Arg Ile Ile Asp Asp Leu Ala Lys Ile Glu Ala Glu Ile Ala Asp 
    450                 455                 460                 
Leu Glu Asp Ile Leu Ala Lys Pro Glu Arg Gln Arg Gly Ile Val Arg 
465                 470                 475                 480 
Asp Glu Leu Ala Glu Ile Val Asp Arg His Gly Asp Asp Arg Arg Thr 
                485                 490                 495     
Arg Ile Ile Ala Ala Asp Gly Asp Val Ser Asp Glu Asp Leu Ile Ala 
            500                 505                 510         
Arg Glu Asp Val Val Val Thr Ile Thr Glu Thr Gly Tyr Ala Lys Arg 
        515                 520                 525             
Thr Lys Thr Asp Leu Tyr Arg Ser Gln Lys Arg Gly Gly Lys Gly Val 
    530                 535                 540                 
Gln Gly Ala Gly Leu Lys Gln Asp Asp Ile Val Ala His Phe Phe Val 
545                 550                 555                 560 
Cys Ser Thr His Asp Leu Ile Leu Phe Phe Thr Thr Gln Gly Arg Val 
                565                 570                 575     
Tyr Arg Ala Lys Ala Tyr Asp Leu Pro Glu Ala Ser Arg Thr Ala Arg 
            580                 585                 590         
Gly Gln His Val Ala Asn Leu Leu Ala Phe Gln Pro Glu Glu Arg Ile 
        595                 600                 605             
Ala Gln Val Ile Gln Ile Arg Gly Tyr Thr Asp Ala Pro Tyr Leu Val 
    610                 615                 620                 
Leu Ala Thr Arg Asn Gly Leu Val Lys Lys Ser Lys Leu Thr Asp Phe 
625                 630                 635                 640 
Asp Ser Asn Arg Ser Gly Gly Ile Val Ala Val Asn Leu Arg Asp Asn 
                645                 650                 655     
Asp Glu Leu Val Gly Ala Val Leu Cys Ser Ala Gly Asp Asp Leu Leu 
            660                 665                 670         
Leu Val Ser Ala Asn Gly Gln Ser Ile Arg Phe Ser Ala Thr Asp Glu 
        675                 680                 685             
Ala Leu Arg Pro Met Gly Arg Ala Thr Ser Gly Val Gln Gly Met Arg 
    690                 695                 700                 
Phe Asn Ile Asp Asp Arg Leu Leu Ser Leu Asn Val Val Arg Glu Gly 
705                 710                 715                 720 
Thr Tyr Leu Leu Val Ala Thr Ser Gly Gly Tyr Ala Lys Arg Thr Ala 
                725                 730                 735     
Ile Glu Glu Tyr Pro Val Gln Gly Arg Gly Gly Lys Gly Val Leu Thr 
            740                 745                 750         
Val Met Tyr Asp Arg Arg Arg Gly Arg Leu Val Gly Ala Leu Ile Val 
        755                 760                 765             
Asp Asp Asp Ser Glu Leu Tyr Ala Val Thr Ser Gly Gly Gly Val Ile 
    770                 775                 780                 
Arg Thr Ala Ala Arg Gln Val Arg Lys Ala Gly Arg Gln Thr Lys Gly 
785                 790                 795                 800 
Val Arg Leu Met Asn Leu Gly Glu Gly Asp Thr Leu Leu Ala Ile Ala 
                805                 810                 815     
Arg Asn Ala Glu Glu Ser Gly Asp Asp Asn Ala Val Asp Ala Asn Gly 
            820                 825                 830         
Ala Asp Gln Thr Gly Asn 
        835             

<210> 19
<211> 528
<212> PRT
<213> Mycobacterium tuberculosis

<220> 
<223> SigA

<400> 19
Met Ala Ala Thr Lys Ala Ser Thr Ala Thr Asp Glu Pro Val Lys Arg 
1               5                   10                  15      
Thr Ala Thr Lys Ser Pro Ala Ala Ser Ala Ser Gly Ala Lys Thr Gly 
            20                  25                  30          
Ala Lys Arg Thr Ala Ala Lys Ser Ala Ser Gly Ser Pro Pro Ala Lys 
        35                  40                  45              
Arg Ala Thr Lys Pro Ala Ala Arg Ser Val Lys Pro Ala Ser Ala Pro 
    50                  55                  60                  
Gln Asp Thr Thr Thr Ser Thr Ile Pro Lys Arg Lys Thr Arg Ala Ala 
65                  70                  75                  80  
Ala Lys Ser Ala Ala Ala Lys Ala Pro Ser Ala Arg Gly His Ala Thr 
                85                  90                  95      
Lys Pro Arg Ala Pro Lys Asp Ala Gln His Glu Ala Ala Thr Asp Pro 
            100                 105                 110         
Glu Asp Ala Leu Asp Ser Val Glu Glu Leu Asp Ala Glu Pro Asp Leu 
        115                 120                 125             
Asp Val Glu Pro Gly Glu Asp Leu Asp Leu Asp Ala Ala Asp Leu Asn 
    130                 135                 140                 
Leu Asp Asp Leu Glu Asp Asp Val Ala Pro Asp Ala Asp Asp Asp Leu 
145                 150                 155                 160 
Asp Ser Gly Asp Asp Glu Asp His Glu Asp Leu Glu Ala Glu Ala Ala 
                165                 170                 175     
Val Ala Pro Gly Gln Thr Ala Asp Asp Asp Glu Glu Ile Ala Glu Pro 
            180                 185                 190         
Thr Glu Lys Asp Lys Ala Ser Gly Asp Phe Val Trp Asp Glu Asp Glu 
        195                 200                 205             
Ser Glu Ala Leu Arg Gln Ala Arg Lys Asp Ala Glu Leu Thr Ala Ser 
    210                 215                 220                 
Ala Asp Ser Val Arg Ala Tyr Leu Lys Gln Ile Gly Lys Val Ala Leu 
225                 230                 235                 240 
Leu Asn Ala Glu Glu Glu Val Glu Leu Ala Lys Arg Ile Glu Ala Gly 
                245                 250                 255     
Leu Tyr Ala Thr Gln Leu Met Thr Glu Leu Ser Glu Arg Gly Glu Lys 
            260                 265                 270         
Leu Pro Ala Ala Gln Arg Arg Asp Met Met Trp Ile Cys Arg Asp Gly 
        275                 280                 285             
Asp Arg Ala Lys Asn His Leu Leu Glu Ala Asn Leu Arg Leu Val Val 
    290                 295                 300                 
Ser Leu Ala Lys Arg Tyr Thr Gly Arg Gly Met Ala Phe Leu Asp Leu 
305                 310                 315                 320 
Ile Gln Glu Gly Asn Leu Gly Leu Ile Arg Ala Val Glu Lys Phe Asp 
                325                 330                 335     
Tyr Thr Lys Gly Tyr Lys Phe Ser Thr Tyr Ala Thr Trp Trp Ile Arg 
            340                 345                 350         
Gln Ala Ile Thr Arg Ala Met Ala Asp Gln Ala Arg Thr Ile Arg Ile 
        355                 360                 365             
Pro Val His Met Val Glu Val Ile Asn Lys Leu Gly Arg Ile Gln Arg 
    370                 375                 380                 
Glu Leu Leu Gln Asp Leu Gly Arg Glu Pro Thr Pro Glu Glu Leu Ala 
385                 390                 395                 400 
Lys Glu Met Asp Ile Thr Pro Glu Lys Val Leu Glu Ile Gln Gln Tyr 
                405                 410                 415     
Ala Arg Glu Pro Ile Ser Leu Asp Gln Thr Ile Gly Asp Glu Gly Asp 
            420                 425                 430         
Ser Gln Leu Gly Asp Phe Ile Glu Asp Ser Glu Ala Val Val Ala Val 
        435                 440                 445             
Asp Ala Val Ser Phe Thr Leu Leu Gln Asp Gln Leu Gln Ser Val Leu 
    450                 455                 460                 
Asp Thr Leu Ser Glu Arg Glu Ala Gly Val Val Arg Leu Arg Phe Gly 
465                 470                 475                 480 
Leu Thr Asp Gly Gln Pro Arg Thr Leu Asp Glu Ile Gly Gln Val Tyr 
                485                 490                 495     
Gly Val Thr Arg Glu Arg Ile Arg Gln Ile Glu Ser Lys Thr Met Ser 
            500                 505                 510         
Lys Leu Arg His Pro Ser Arg Ser Gln Val Leu Arg Asp Tyr Leu Asp 
        515                 520                 525             



<210> 20
<211> 144
<212> PRT
<213> Mycobacterium tuberculosis

<220> 
<223> HspX

<400> 20
Met Ala Thr Thr Leu Pro Val Gln Arg His Pro Arg Ser Leu Phe Pro 
1               5                   10                  15      
Glu Phe Ser Glu Leu Phe Ala Ala Phe Pro Ser Phe Ala Gly Leu Arg 
            20                  25                  30          
Pro Thr Phe Asp Thr Arg Leu Met Arg Leu Glu Asp Glu Met Lys Glu 
        35                  40                  45              
Gly Arg Tyr Glu Val Arg Ala Glu Leu Pro Gly Val Asp Pro Asp Lys 
    50                  55                  60                  
Asp Val Asp Ile Met Val Arg Asp Gly Gln Leu Thr Ile Lys Ala Glu 
65                  70                  75                  80  
Arg Thr Glu Gln Lys Asp Phe Asp Gly Arg Ser Glu Phe Ala Tyr Gly 
                85                  90                  95      
Ser Phe Val Arg Thr Val Ser Leu Pro Val Gly Ala Asp Glu Asp Asp 
            100                 105                 110         
Ile Lys Ala Thr Tyr Asp Lys Gly Ile Leu Thr Val Ser Val Ala Val 
        115                 120                 125             
Ser Glu Gly Lys Pro Thr Glu Lys His Ile Gln Ile Arg Ser Thr Asn 
    130                 135                 140                 



<210> 21
<211> 652
<212> PRT
<213> Mycobacterium tuberculosis

<220> 
<223> NarX

<400> 21
Met Thr Val Thr Pro Arg Thr Gly Ser Arg Ile Glu Glu Leu Leu Ala 
1               5                   10                  15      
Arg Ser Gly Arg Phe Phe Ile Pro Gly Glu Ile Ser Ala Asp Leu Arg 
            20                  25                  30          
Thr Val Thr Arg Arg Gly Gly Arg Asp Gly Asp Val Phe Tyr Arg Asp 
        35                  40                  45              
Arg Trp Ser His Asp Lys Val Val Arg Ser Thr His Gly Val Asn Cys 
    50                  55                  60                  
Thr Gly Ser Cys Ser Trp Lys Ile Tyr Val Lys Asp Asp Ile Ile Thr 
65                  70                  75                  80  
Trp Glu Thr Gln Glu Thr Asp Tyr Pro Ser Val Gly Pro Asp Arg Pro 
                85                  90                  95      
Glu Tyr Glu Pro Arg Gly Cys Pro Arg Gly Ala Ala Phe Ser Trp Tyr 
            100                 105                 110         
Thr Tyr Ser Pro Thr Arg Val Arg His Pro Tyr Ala Arg Gly Val Leu 
        115                 120                 125             
Val Glu Met Tyr Arg Glu Ala Lys Ala Arg Leu Gly Asp Pro Val Ala 
    130                 135                 140                 
Ala Trp Ala Asp Ile Gln Ala Asp Pro Arg Arg Arg Arg Arg Tyr Gln 
145                 150                 155                 160 
Arg Ala Arg Gly Lys Gly Gly Leu Val Arg Val Ser Trp Ala Glu Ala 
                165                 170                 175     
Thr Glu Met Ile Ala Ala Ala His Val His Thr Ile Ser Thr Tyr Gly 
            180                 185                 190         
Pro Asp Arg Val Ala Gly Phe Ser Pro Ile Pro Ala Met Ser Met Val 
        195                 200                 205             
Ser His Ala Ala Gly Ser Arg Phe Val Glu Leu Ile Gly Gly Val Met 
    210                 215                 220                 
Thr Ser Phe Tyr Asp Trp Tyr Ala Asp Leu Pro Val Ala Ser Pro Gln 
225                 230                 235                 240 
Val Phe Gly Asp Gln Thr Asp Val Pro Glu Ser Gly Asp Trp Trp Asp 
                245                 250                 255     
Val Val Trp Gln Cys Ala Ser Val Leu Leu Thr Tyr Pro Asn Ser Arg 
            260                 265                 270         
Gln Leu Gly Thr Ala Glu Glu Leu Leu Ala His Ile Asp Gly Pro Ala 
        275                 280                 285             
Ala Asp Leu Leu Gly Arg Thr Val Ser Glu Leu Arg Arg Ala Asp Pro 
    290                 295                 300                 
Leu Thr Ala Ala Thr Arg Tyr Val Asp Thr Phe Asp Leu Arg Gly Arg 
305                 310                 315                 320 
Ala Thr Leu Tyr Leu Thr Tyr Trp Thr Ala Gly Asp Thr Arg Asn Arg 
                325                 330                 335     
Gly Arg Glu Met Leu Ala Phe Ala Gln Thr Tyr Arg Ser Thr Asp Val 
            340                 345                 350         
Ala Pro Pro Arg Gly Glu Thr Pro Asp Phe Leu Pro Val Val Leu Glu 
        355                 360                 365             
Phe Ala Ala Thr Val Asp Pro Glu Ala Gly Arg Arg Leu Leu Ser Gly 
    370                 375                 380                 
Tyr Arg Val Pro Ile Ala Ala Leu Cys Asn Ala Leu Thr Glu Ala Ala 
385                 390                 395                 400 
Leu Pro Tyr Ala His Thr Val Ala Ala Val Cys Arg Thr Gly Asp Met 
                405                 410                 415     
Met Gly Glu Leu Phe Trp Thr Val Val Pro Tyr Val Thr Met Thr Ile 
            420                 425                 430         
Val Ala Val Gly Ser Trp Trp Arg Tyr Arg Tyr Asp Lys Phe Gly Trp 
        435                 440                 445             
Thr Thr Arg Ser Ser Gln Leu Tyr Glu Ser Arg Leu Leu Arg Ile Ala 
    450                 455                 460                 
Ser Pro Met Phe His Phe Gly Ile Leu Val Val Ile Val Gly His Gly 
465                 470                 475                 480 
Ile Gly Leu Val Ile Pro Gln Ser Trp Thr Gln Ala Ala Gly Leu Ser 
                485                 490                 495     
Glu Gly Ala Tyr His Val Gln Ala Val Val Leu Gly Ser Ile Ala Gly 
            500                 505                 510         
Ile Thr Thr Leu Ala Gly Val Thr Leu Leu Ile Tyr Arg Arg Arg Thr 
        515                 520                 525             
Arg Gly Pro Val Phe Met Ala Thr Thr Val Asn Asp Lys Val Met Tyr 
    530                 535                 540                 
Leu Val Leu Val Ala Ala Ile Val Ala Gly Leu Gly Ala Thr Ala Leu 
545                 550                 555                 560 
Gly Ser Gly Val Val Gly Glu Ala Tyr Asn Tyr Arg Glu Thr Val Ser 
                565                 570                 575     
Val Trp Phe Arg Ser Val Trp Val Leu Gln Pro Arg Gly Asp Leu Met 
            580                 585                 590         
Ala Glu Ala Pro Leu Tyr Tyr Gln Ile His Val Leu Ile Gly Leu Ala 
        595                 600                 605             
Leu Phe Ala Leu Trp Pro Phe Thr Arg Leu Val His Ala Phe Ser Ala 
    610                 615                 620                 
Pro Ile Gly Tyr Leu Phe Arg Pro Tyr Ile Ile Tyr Arg Ser Arg Glu 
625                 630                 635                 640 
Glu Leu Val Leu Thr Arg Pro Arg Arg Arg Gly Trp 
                645                 650         

<210> 22
<211> 114
<212> PRT
<213> Mycobacterium tuberculosis

<220> 
<223> fdxA

<400> 22
Met Thr Tyr Val Ile Gly Ser Glu Cys Val Asp Val Met Asp Lys Ser 
1               5                   10                  15      
Cys Val Gln Glu Cys Pro Val Asp Cys Ile Tyr Glu Gly Ala Arg Met 
            20                  25                  30          
Leu Tyr Ile Asn Pro Asp Glu Cys Val Asp Cys Gly Ala Cys Lys Pro 
        35                  40                  45              
Ala Cys Arg Val Glu Ala Ile Tyr Trp Glu Gly Asp Leu Pro Asp Asp 
    50                  55                  60                  
Gln His Gln His Leu Gly Asp Asn Ala Ala Phe Phe His Gln Val Leu 
65                  70                  75                  80  
Pro Gly Arg Val Ala Pro Leu Gly Ser Pro Gly Gly Ala Ala Ala Val 
                85                  90                  95      
Gly Pro Ile Gly Val Asp Thr Pro Leu Val Ala Ala Ile Pro Val Glu 
            100                 105                 110         
Cys Pro 
        

<210> 23
<211> 55
<212> PRT
<213> Mycobacterium tuberculosis

<220> 
<223> rubA

<400> 23
Met Ala Ala Tyr Arg Cys Pro Val Cys Asp Tyr Val Tyr Asp Glu Ala 
1               5                   10                  15      
Asn Gly Asp Ala Arg Glu Gly Phe Pro Ala Gly Thr Gly Trp Asp Gln 
            20                  25                  30          
Ile Pro Asp Asp Trp Cys Cys Pro Asp Cys Ala Val Arg Glu Lys Val 
        35                  40                  45              
Asp Phe Glu Lys Ile Gly Gly 
    50                  55  

<210> 24
<211> 407
<212> PRT
<213> Mycobacterium tuberculosis

<220> 
<223> RpfA

<400> 24
Met Ser Gly Arg His Arg Lys Pro Thr Thr Ser Asn Val Ser Val Ala 
1               5                   10                  15      
Lys Ile Ala Phe Thr Gly Ala Val Leu Gly Gly Gly Gly Ile Ala Met 
            20                  25                  30          
Ala Ala Gln Ala Thr Ala Ala Thr Asp Gly Glu Trp Asp Gln Val Ala 
        35                  40                  45              
Arg Cys Glu Ser Gly Gly Asn Trp Ser Ile Asn Thr Gly Asn Gly Tyr 
    50                  55                  60                  
Leu Gly Gly Leu Gln Phe Thr Gln Ser Thr Trp Ala Ala His Gly Gly 
65                  70                  75                  80  
Gly Glu Phe Ala Pro Ser Ala Gln Leu Ala Ser Arg Glu Gln Gln Ile 
                85                  90                  95      
Ala Val Gly Glu Arg Val Leu Ala Thr Gln Gly Arg Gly Ala Trp Pro 
            100                 105                 110         
Val Cys Gly Arg Gly Leu Ser Asn Ala Thr Pro Arg Glu Val Leu Pro 
        115                 120                 125             
Ala Ser Ala Ala Met Asp Ala Pro Leu Asp Ala Ala Ala Val Asn Gly 
    130                 135                 140                 
Glu Pro Ala Pro Leu Ala Pro Pro Pro Ala Asp Pro Ala Pro Pro Val 
145                 150                 155                 160 
Glu Leu Ala Ala Asn Asp Leu Pro Ala Pro Leu Gly Glu Pro Leu Pro 
                165                 170                 175     
Ala Ala Pro Ala Asp Pro Ala Pro Pro Ala Asp Leu Ala Pro Pro Ala 
            180                 185                 190         
Pro Ala Asp Val Ala Pro Pro Val Glu Leu Ala Val Asn Asp Leu Pro 
        195                 200                 205             
Ala Pro Leu Gly Glu Pro Leu Pro Ala Ala Pro Ala Asp Pro Ala Pro 
    210                 215                 220                 
Pro Ala Asp Leu Ala Pro Pro Ala Pro Ala Asp Leu Ala Pro Pro Ala 
225                 230                 235                 240 
Pro Ala Asp Leu Ala Pro Pro Ala Pro Ala Asp Leu Ala Pro Pro Val 
                245                 250                 255     
Glu Leu Ala Val Asn Asp Leu Pro Ala Pro Leu Gly Glu Pro Leu Pro 
            260                 265                 270         
Ala Ala Pro Ala Glu Leu Ala Pro Pro Ala Asp Leu Ala Pro Ala Ser 
        275                 280                 285             
Ala Asp Leu Ala Pro Pro Ala Pro Ala Asp Leu Ala Pro Pro Ala Pro 
    290                 295                 300                 
Ala Glu Leu Ala Pro Pro Ala Pro Ala Asp Leu Ala Pro Pro Ala Ala 
305                 310                 315                 320 
Val Asn Glu Gln Thr Ala Pro Gly Asp Gln Pro Ala Thr Ala Pro Gly 
                325                 330                 335     
Gly Pro Val Gly Leu Ala Thr Asp Leu Glu Leu Pro Glu Pro Asp Pro 
            340                 345                 350         
Gln Pro Ala Asp Ala Pro Pro Pro Gly Asp Val Thr Glu Ala Pro Ala 
        355                 360                 365             
Glu Thr Pro Gln Val Ser Asn Ile Ala Tyr Thr Lys Lys Leu Trp Gln 
    370                 375                 380                 
Ala Ile Arg Ala Gln Asp Val Cys Gly Asn Asp Ala Leu Asp Ser Leu 
385                 390                 395                 400 
Ala Gln Pro Tyr Val Ile Gly 
                405         

<210> 25
<211> 583
<212> PRT
<213> Mycobacterium tuberculosis

<220> 
<223> fadD26

<400> 25
Met Pro Val Thr Asp Arg Ser Val Pro Ser Leu Leu Gln Glu Arg Ala 
1               5                   10                  15      
Asp Gln Gln Pro Asp Ser Thr Ala Tyr Thr Tyr Ile Asp Tyr Gly Ser 
            20                  25                  30          
Asp Pro Lys Gly Phe Ala Asp Ser Leu Thr Trp Ser Gln Val Tyr Ser 
        35                  40                  45              
Arg Ala Cys Ile Ile Ala Glu Glu Leu Lys Leu Cys Gly Leu Pro Gly 
    50                  55                  60                  
Asp Arg Val Ala Val Leu Ala Pro Gln Gly Leu Glu Tyr Val Leu Ala 
65                  70                  75                  80  
Phe Leu Gly Ala Leu Gln Ala Gly Phe Ile Ala Val Pro Leu Ser Thr 
                85                  90                  95      
Pro Gln Tyr Gly Ile His Asp Asp Arg Val Ser Ala Val Leu Gln Asp 
            100                 105                 110         
Ser Lys Pro Val Ala Ile Leu Thr Thr Ser Ser Val Val Gly Asp Val 
        115                 120                 125             
Thr Lys Tyr Ala Ala Ser His Asp Gly Gln Pro Ala Pro Val Val Val 
    130                 135                 140                 
Glu Val Asp Leu Leu Asp Leu Asp Ser Pro Arg Gln Met Pro Ala Phe 
145                 150                 155                 160 
Ser Arg Gln His Thr Gly Ala Ala Tyr Leu Gln Tyr Thr Ser Gly Ser 
                165                 170                 175     
Thr Arg Thr Pro Ala Gly Val Ile Val Ser His Thr Asn Val Ile Ala 
            180                 185                 190         
Asn Val Thr Gln Ser Met Tyr Gly Tyr Phe Gly Asp Pro Ala Lys Ile 
        195                 200                 205             
Pro Thr Gly Thr Val Val Ser Trp Leu Pro Leu Tyr His Asp Met Gly 
    210                 215                 220                 
Leu Ile Leu Gly Ile Cys Ala Pro Leu Val Ala Arg Arg Arg Ala Met 
225                 230                 235                 240 
Leu Met Ser Pro Met Ser Phe Leu Arg Arg Pro Ala Arg Trp Met Gln 
                245                 250                 255     
Leu Leu Ala Thr Ser Gly Arg Cys Phe Ser Ala Ala Pro Asn Phe Ala 
            260                 265                 270         
Phe Glu Leu Ala Val Arg Arg Thr Ser Asp Gln Asp Met Ala Gly Leu 
        275                 280                 285             
Asp Leu Arg Asp Val Val Gly Ile Val Ser Gly Ser Glu Arg Ile His 
    290                 295                 300                 
Val Ala Thr Val Arg Arg Phe Ile Glu Arg Phe Ala Pro Tyr Asn Leu 
305                 310                 315                 320 
Ser Pro Thr Ala Ile Arg Pro Ser Tyr Gly Leu Ala Glu Ala Thr Leu 
                325                 330                 335     
Tyr Val Ala Ala Pro Glu Ala Gly Ala Ala Pro Lys Thr Val Arg Phe 
            340                 345                 350         
Asp Tyr Glu Gln Leu Thr Ala Gly Gln Ala Arg Pro Cys Gly Thr Asp 
        355                 360                 365             
Gly Ser Val Gly Thr Glu Leu Ile Ser Tyr Gly Ser Pro Asp Pro Ser 
    370                 375                 380                 
Ser Val Arg Ile Val Asn Pro Glu Thr Met Val Glu Asn Pro Pro Gly 
385                 390                 395                 400 
Val Val Gly Glu Ile Trp Val His Gly Asp His Val Thr Met Gly Tyr 
                405                 410                 415     
Trp Gln Lys Pro Lys Gln Thr Ala Gln Val Phe Asp Ala Lys Leu Val 
            420                 425                 430         
Asp Pro Ala Pro Ala Ala Pro Glu Gly Pro Trp Leu Arg Thr Gly Asp 
        435                 440                 445             
Leu Gly Val Ile Ser Asp Gly Glu Leu Phe Ile Met Gly Arg Ile Lys 
    450                 455                 460                 
Asp Leu Leu Ile Val Asp Gly Arg Asn His Tyr Pro Asp Asp Ile Glu 
465                 470                 475                 480 
Ala Thr Ile Gln Glu Ile Thr Gly Gly Arg Ala Ala Ala Ile Ala Val 
                485                 490                 495     
Pro Asp Asp Ile Thr Glu Gln Leu Val Ala Ile Ile Glu Phe Lys Arg 
            500                 505                 510         
Arg Gly Ser Thr Ala Glu Glu Val Met Leu Lys Leu Arg Ser Val Lys 
        515                 520                 525             
Arg Glu Val Thr Ser Ala Ile Ser Lys Ser His Ser Leu Arg Val Ala 
    530                 535                 540                 
Asp Leu Val Leu Val Ser Pro Gly Ser Ile Pro Ile Thr Thr Ser Gly 
545                 550                 555                 560 
Lys Ile Arg Arg Ser Ala Cys Val Glu Arg Tyr Arg Ser Asp Gly Phe 
                565                 570                 575     
Lys Arg Leu Asp Val Ala Val 
            580             

<210> 26
<211> 390
<212> PRT
<213> Mycobacterium tuberculosis

<220> 
<223> fadE9

<400> 26
Met Phe Val Leu Asn Asp Asp Glu Arg Val Ile Val Glu Thr Ala Ala 
1               5                   10                  15      
Ala Phe Ala Gly Lys Arg Leu Ala Pro His Ala Leu Glu Trp Asp Ala 
            20                  25                  30          
Ala Lys His Phe Pro Val Asp Val Leu Arg Glu Ala Ala Glu Leu Gly 
        35                  40                  45              
Met Ala Ala Ile Tyr Cys Arg Asp Asp Val Gly Gly Ser Gly Leu Arg 
    50                  55                  60                  
Arg Leu Asp Gly Val Arg Ile Phe Glu Gln Leu Ala Ile Ala Asp Pro 
65                  70                  75                  80  
Val Thr Ala Ala Phe Leu Ser Ile His Asn Met Cys Ala Trp Met Ile 
                85                  90                  95      
Asp Ser Phe Gly Thr Asp Glu Gln Arg Lys Asp Trp Ile Pro Arg Leu 
            100                 105                 110         
Ala Thr Met Gly Val Ile Ala Ser Tyr Cys Leu Thr Glu Pro Gly Ala 
        115                 120                 125             
Gly Ser Asp Ala Gly Ala Leu Ser Thr Arg Ala Val Arg His Gly Ser 
    130                 135                 140                 
Gly Lys Gly Gly Asp Tyr Val Leu Asp Gly Val Lys Gln Phe Ile Ser 
145                 150                 155                 160 
Gly Ala Ala Ala Ser Asp Val Tyr Val Val Met Ala Arg Thr Gly Ala 
                165                 170                 175     
Glu Gly Pro Arg Gly Val Ser Ala Phe Ile Val Glu Lys Gly Thr Pro 
            180                 185                 190         
Gly Leu Ser Phe Gly Ala Pro Glu Ala Lys Met Gly Trp His Ala Gln 
        195                 200                 205             
Pro Thr Ala Gln Val Val Leu Asp Gly Val Arg Val Pro Ala Glu Ala 
    210                 215                 220                 
Met Leu Gly Gly Ala Asp Gly Glu Gly Ala Gly Phe Gly Ile Ala Met 
225                 230                 235                 240 
Ser Gly Leu Asn Gly Gly Arg Leu Asn Ile Ala Ala Cys Ser Leu Gly 
                245                 250                 255     
Gly Ala Gln Ala Ala Phe Asp Lys Ala Gly Ala Tyr Val Arg Asp Arg 
            260                 265                 270         
Gln Ala Phe Gly Gly Ser Leu Leu Asp Glu Pro Thr Val Arg Phe Thr 
        275                 280                 285             
Leu Ala Asp Met Ala Thr Gly Leu Gln Thr Ser Arg Met Leu Leu Trp 
    290                 295                 300                 
Arg Ala Ala Ser Ala Leu Asp Asp Asp Asp Ala Asp Lys Val Glu Leu 
305                 310                 315                 320 
Cys Ala Met Ala Lys Arg Tyr Val Thr Asp Thr Cys Phe Glu Val Ala 
                325                 330                 335     
Asp Gln Ala Leu Gln Leu His Gly Gly Tyr Gly Tyr Leu Arg Glu Tyr 
            340                 345                 350         
Gly Leu Glu Lys Ile Val Arg Asp Leu Arg Val His Arg Ile Leu Glu 
        355                 360                 365             
Gly Thr Asn Glu Ile Met Arg Leu Val Ile Gly Arg Ala Glu Ala Ala 
    370                 375                 380                 
Arg Phe Arg Ala Thr Val 
385                 390 

<210> 27
<211> 250
<212> PRT
<213> Mycobacterium tuberculosis

<220> 
<223> Rv0116c

<400> 27
Arg Arg Val Val Arg Tyr Leu Ser Val Val Val Ala Ile Thr Leu Met 
1               5                   10                  15      
Leu Thr Ala Glu Ser Val Ser Ile Ala Thr Ala Ala Val Pro Pro Leu 
            20                  25                  30          
Gln Pro Ile Pro Gly Val Ala Ser Val Ser Pro Ala Asn Gly Ala Val 
        35                  40                  45              
Val Gly Val Ala His Pro Val Val Val Thr Phe Thr Thr Pro Val Thr 
    50                  55                  60                  
Asp Arg Arg Ala Val Glu Arg Ser Ile Arg Ile Ser Thr Pro His Asn 
65                  70                  75                  80  
Thr Thr Gly His Phe Glu Trp Val Ala Ser Asn Val Val Arg Trp Val 
                85                  90                  95      
Pro His Arg Tyr Trp Pro Pro His Thr Arg Val Ser Val Gly Val Gln 
            100                 105                 110         
Glu Leu Thr Glu Gly Phe Glu Thr Gly Asp Ala Leu Ile Gly Val Ala 
        115                 120                 125             
Ser Ile Ser Ala His Thr Phe Thr Val Ser Arg Asn Gly Glu Val Leu 
    130                 135                 140                 
Arg Thr Met Pro Ala Ser Leu Gly Lys Pro Ser Arg Pro Thr Pro Ile 
145                 150                 155                 160 
Gly Ser Phe His Ala Met Ser Lys Glu Arg Thr Val Val Met Asp Ser 
                165                 170                 175     
Arg Thr Ile Gly Ile Pro Leu Asn Ser Ser Asp Gly Tyr Leu Leu Thr 
            180                 185                 190         
Ala His Tyr Ala Val Arg Val Thr Trp Ser Gly Val Tyr Val His Ser 
        195                 200                 205             
Ala Pro Trp Ser Val Asn Ser Gln Gly Tyr Ala Asn Val Ser His Gly 
    210                 215                 220                 
Cys Ile Asn Leu Ser Pro Asp Asn Ala Ala Trp Tyr Phe Asp Ala Val 
225                 230                 235                 240 
Thr Val Gly Asp Pro Ile Glu Val Val Gly 
                245                 250 

<210> 28
<211> 335
<212> PRT
<213> Mycobacterium tuberculosis

<220> 
<223> trxB

<400> 28
Met Thr Ala Pro Pro Val His Asp Arg Ala His His Pro Val Arg Asp 
1               5                   10                  15      
Val Ile Val Ile Gly Ser Gly Pro Ala Gly Tyr Thr Ala Ala Leu Tyr 
            20                  25                  30          
Ala Ala Arg Ala Gln Leu Ala Pro Leu Val Phe Glu Gly Thr Ser Phe 
        35                  40                  45              
Gly Gly Ala Leu Met Thr Thr Thr Asp Val Glu Asn Tyr Pro Gly Phe 
    50                  55                  60                  
Arg Asn Gly Ile Thr Gly Pro Glu Leu Met Asp Glu Met Arg Glu Gln 
65                  70                  75                  80  
Ala Leu Arg Phe Gly Ala Asp Leu Arg Met Glu Asp Val Glu Ser Val 
                85                  90                  95      
Ser Leu His Gly Pro Leu Lys Ser Val Val Thr Ala Asp Gly Gln Thr 
            100                 105                 110         
His Arg Ala Arg Ala Val Ile Leu Ala Met Gly Ala Ala Ala Arg Tyr 
        115                 120                 125             
Leu Gln Val Pro Gly Glu Gln Glu Leu Leu Gly Arg Gly Val Ser Ser 
    130                 135                 140                 
Cys Ala Thr Cys Asp Gly Phe Phe Phe Arg Asp Gln Asp Ile Ala Val 
145                 150                 155                 160 
Ile Gly Gly Gly Asp Ser Ala Met Glu Glu Ala Thr Phe Leu Thr Arg 
                165                 170                 175     
Phe Ala Arg Ser Val Thr Leu Val His Arg Arg Asp Glu Phe Arg Ala 
            180                 185                 190         
Ser Lys Ile Met Leu Asp Arg Ala Arg Asn Asn Asp Lys Ile Arg Phe 
        195                 200                 205             
Leu Thr Asn His Thr Val Val Ala Val Asp Gly Asp Thr Thr Val Thr 
    210                 215                 220                 
Gly Leu Arg Val Arg Asp Thr Asn Thr Gly Ala Glu Thr Thr Leu Pro 
225                 230                 235                 240 
Val Thr Gly Val Phe Val Ala Ile Gly His Glu Pro Arg Ser Gly Leu 
                245                 250                 255     
Val Arg Glu Ala Ile Asp Val Asp Pro Asp Gly Tyr Val Leu Val Gln 
            260                 265                 270         
Gly Arg Thr Thr Ser Thr Ser Leu Pro Gly Val Phe Ala Ala Gly Asp 
        275                 280                 285             
Leu Val Asp Arg Thr Tyr Arg Gln Ala Val Thr Ala Ala Gly Ser Gly 
    290                 295                 300                 
Cys Ala Ala Ala Ile Asp Ala Glu Arg Trp Leu Ala Glu His Ala Ala 
305                 310                 315                 320 
Thr Gly Glu Ala Asp Ser Thr Asp Ala Leu Ile Gly Ala Gln Arg 
                325                 330                 335 

<210> 29
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer

<400> 29
cgtggaggcg atcacaccgc agac                                           24


<210> 30
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer

<400> 30
agctccagcc cggcacgctc acgt                                           24


<210> 31
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer

<400> 31
caggcatcgt cgtcagcagc                                                20


<210> 32
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer

<400> 32
gtgattggct tgcgataggc                                                20


<210> 33
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> human GAPDH s

<400> 33
ctccccacac acatgcactt a                                              21


<210> 34
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> human GAPDH as

<400> 34
cctagtccca gggctttgat t                                              21


<210> 35
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> mouse GAPDH

<400> 35
catgttccaa tatgattcca c                                              21


<210> 36
<211> 17
<212> DNA
<213> Artificial Sequence

<220> 
<223> mouse GAPDH

<400> 36
cctggaagat ggtgatg                                                   17


