               SEQUENCE LISTING

<110> INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE (INRA)
      CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)

<120> Diet controlled expression of a nucleic acid encoding a pro-apoptotic protein

<130> PR77922

<150> US62/345,162 
<151> 2016-06-03

<160> 8

<170> BiSSAP 1.3.6

<210> 1
<211> 16
<212> DNA
<213> Artificial Sequence


<220> 
<223> AARE sequence from the TRIB3 gene

<400> 1
cggtttgcat cacccg                                                    16


<210> 2
<211> 16
<212> DNA
<213> Artificial Sequence


<220> 
<223> AARE sequence from the CHOP gene

<400> 2
aacattgcat catccc                                                    16


<210> 3
<211> 16
<212> DNA
<213> Artificial Sequence


<220> 
<223> AARE sequence from the ASNS gene

<400> 3
gaagtttcat catgcc                                                    16


<210> 4
<211> 16
<212> DNA
<213> Artificial Sequence


<220> 
<223> AARE sequence from the ATF3 gene

<400> 4
agcgttgcat cacccc                                                    16


<210> 5
<211> 16
<212> DNA
<213> Artificial Sequence


<220> 
<223> AARE sequence from the SNAT2 gene

<400> 5
gatattgcat cagttt                                                    16


<210> 6
<211> 317
<212> DNA
<213> Artificial Sequence


<220> 
<223> Regulatory polypeptide comprising the Thymidine kinase (Tk)
      minimal promoter and six copies of the AARE nucleic acid sequence
      from the TRIB3 gene

<400> 6
ggtaccgatt agctccggtt tgcatcaccc ggaccggggg attagctccg gtttgcatca      60

cccggaccgg gggattagct ccggtttgca tcacccggac cgggggccgg gcgcgtgcta     120

gcgattagct ccggtttgca tcacccggac cgggggatta gctccggttt gcatcacccg     180

gaccggggga ttagctccgg tttgcatcac ccggaccggg gactcgaggt ccacttcgca     240

tattaaggtg acgcgtgtgg cctcgaacac cgagcgaccc tgcagcgacc cgcttaacag     300

cgtcaacagc gtgccgc                                                    317


<210> 7
<211> 864
<212> DNA
<213> Artificial Sequence


<220> 
<223> cDNA of TRAIL protein

<400> 7
atggctatga tggaggtcca ggggggaccc agcctgggac agacctgcgt gctgatcgtg      60

atcttcacag tgctcctgca gtctctctgt gtggctgtaa cttacgtgta ctttaccaac     120

gagctgaagc agatgcagga caagtactcc aaaagtggca ttgcttgttt cttaaaagaa     180

gatgacagtt attgggaccc caatgacgaa gagagtatga acagcccctg ctggcaagtc     240

aagtggcaac tccgtcagct cgttagaaag atgattttga gaacctctga ggaaaccatt     300

tctacagttc aagaaaagca acaaaatatt tctcccctag tgagagaaag aggtcctcag     360

agagtagcag ctcacataac tgggaccaga ggaagaagca acacattgtc ttctccaaac     420

tccaagaatg aaaaggctct gggccgcaaa ataaactcct gggaatcatc aaggagtggg     480

cattcattcc tgagcaactt gcacttgagg aatggtgaac tggtcatcca tgaaaaaggg     540

ttttactaca tctattccca aacatacttt cgatttcagg aggaaataaa agaaaacaca     600

aagaacgaca aacaaatggt ccaatatatt tacaaataca caagttatcc tgaccctata     660

ttgttgatga aaagtgctag aaatagttgt tggtctaaag atgcagaata tggactctat     720

tccatctatc aagggggaat atttgagctt aaggaaaatg acagaatttt tgtttctgta     780

acaaatgagc acttgataga catggaccat gaagccagtt tttttggggc ctttttagtt     840

ggctaaaccg gtgctagctc taga                                            864


<210> 8
<211> 3806
<212> DNA
<213> Artificial Sequence


<220> 
<223> Plasmid pENTR comprising six copies of the AARE nucleic acid from
      Trib3 gene sequence, Tk minimal promoter and the cDNA encoding
      for TRAIL protein

<400> 8
caccggtacc gattagctcc ggtttgcatc acccggaccg ggggattagc tccggtttgc       60

atcacccgga ccgggggatt agctccggtt tgcatcaccc ggaccggggg ccgggcgcgt      120

gctagcgatt agctccggtt tgcatcaccc ggaccggggg attagctccg gtttgcatca      180

cccggaccgg gggattagct ccggtttgca tcacccggac cggggactcg aggtccactt      240

cgcatattaa ggtgacgcgt gtggcctcga acaccgagcg accctgcagc gacccgctta      300

acagcgtcaa cagcgtgccg caagcttgaa ttctgatcag cattccggta ctgttggaaa      360

gccaccatgg ctatgatgga ggtccagggg ggacccagcc tgggacagac ctgcgtgctg      420

atcgtgatct tcacagtgct cctgcagtct ctctgtgtgg ctgtaactta cgtgtacttt      480

accaacgagc tgaagcagat gcaggacaag tactccaaaa gtggcattgc ttgtttctta      540

aaagaagatg acagttattg ggaccccaat gacgaagaga gtatgaacag cccctgctgg      600

caagtcaagt ggcaactccg tcagctcgtt agaaagatga ttttgagaac ctctgaggaa      660

accatttcta cagttcaaga aaagcaacaa aatatttctc ccctagtgag agaaagaggt      720

cctcagagag tagcagctca cataactggg accagaggaa gaagcaacac attgtcttct      780

ccaaactcca agaatgaaaa ggctctgggc cgcaaaataa actcctggga atcatcaagg      840

agtgggcatt cattcctgag caacttgcac ttgaggaatg gtgaactggt catccatgaa      900

aaagggtttt actacatcta ttcccaaaca tactttcgat ttcaggagga aataaaagaa      960

aacacaaaga acgacaaaca aatggtccaa tatatttaca aatacacaag ttatcctgac     1020

cctatattgt tgatgaaaag tgctagaaat agttgttggt ctaaagatgc agaatatgga     1080

ctctattcca tctatcaagg gggaatattt gagcttaagg aaaatgacag aatttttgtt     1140

tctgtaacaa atgagcactt gatagacatg gaccatgaag ccagtttttt tggggccttt     1200

ttagttggct aaaccggtgc tagctctaga aagggtgggc gcgccgaccc agctttcttg     1260

tacaaagttg gcattataag aaagcattgc ttatcaattt gttgcaacga acaggtcact     1320

atcagtcaaa ataaaatcat tatttgccat ccagctgata tcccctatag tgagtcgtat     1380

tacatggtca tagctgtttc ctggcagctc tggcccgtgt ctcaaaatct ctgatgttac     1440

attgcacaag ataaaaatat atcatcatga acaataaaac tgtctgctta cataaacagt     1500

aatacaaggg gtgttatgag ccatattcaa cgggaaacgt cgaggccgcg attaaattcc     1560

aacatggatg ctgatttata tgggtataaa tgggctcgcg ataatgtcgg gcaatcaggt     1620

gcgacaatct atcgcttgta tgggaagccc gatgcgccag agttgtttct gaaacatggc     1680

aaaggtagcg ttgccaatga tgttacagat gagatggtca gactaaactg gctgacggaa     1740

tttatgcctc ttccgaccat caagcatttt atccgtactc ctgatgatgc atggttactc     1800

accactgcga tccccggaaa aacagcattc caggtattag aagaatatcc tgattcaggt     1860

gaaaatattg ttgatgcgct ggcagtgttc ctgcgccggt tgcattcgat tcctgtttgt     1920

aattgtcctt ttaacagcga tcgcgtattt cgtctcgctc aggcgcaatc acgaatgaat     1980

aacggtttgg ttgatgcgag tgattttgat gacgagcgta atggctggcc tgttgaacaa     2040

gtctggaaag aaatgcataa acttttgcca ttctcaccgg attcagtcgt cactcatggt     2100

gatttctcac ttgataacct tatttttgac gaggggaaat taataggttg tattgatgtt     2160

ggacgagtcg gaatcgcaga ccgataccag gatcttgcca tcctatggaa ctgcctcggt     2220

gagttttctc cttcattaca gaaacggctt tttcaaaaat atggtattga taatcctgat     2280

atgaataaat tgcagtttca tttgatgctc gatgagtttt tctaatcaga attggttaat     2340

tggttgtaac actggcagag cattacgctg acttgacggg acggcgcaag ctcatgacca     2400

aaatccctta acgtgagtta cgcgtcgttc cactgagcgt cagaccccgt agaaaagatc     2460

aaaggatctt cttgagatcc tttttttctg cgcgtaatct gctgcttgca aacaaaaaaa     2520

ccaccgctac cagcggtggt ttgtttgccg gatcaagagc taccaactct ttttccgaag     2580

gtaactggct tcagcagagc gcagatacca aatactgtcc ttctagtgta gccgtagtta     2640

ggccaccact tcaagaactc tgtagcaccg cctacatacc tcgctctgct aatcctgtta     2700

ccagtggctg ctgccagtgg cgataagtcg tgtcttaccg ggttggactc aagacgatag     2760

ttaccggata aggcgcagcg gtcgggctga acggggggtt cgtgcacaca gcccagcttg     2820

gagcgaacga cctacaccga actgagatac ctacagcgtg agcattgaga aagcgccacg     2880

cttcccgaag ggagaaaggc ggacaggtat ccggtaagcg gcagggtcgg aacaggagag     2940

cgcacgaggg agcttccagg gggaaacgcc tggtatcttt atagtcctgt cgggtttcgc     3000

cacctctgac ttgagcgtcg atttttgtga tgctcgtcag gggggcggag cctatggaaa     3060

aacgccagca acgcggcctt tttacggttc ctggcctttt gctggccttt tgctcacatg     3120

ttctttcctg cgttatcccc tgattctgtg gataaccgta ttaccgcctt tgagtgagct     3180

gataccgctc gccgcagccg aacgaccgag cgcagcgagt cagtgagcga ggaagcggaa     3240

gagcgcccaa tacgcaaacc gcctctcccc gcgcgttggc cgattcatta atgcagctgg     3300

cacgacaggt ttcccgactg gaaagcgggc agtgagcgca acgcaattaa tacgcgtacc     3360

gctagccagg aagagtttgt agaaacgcaa aaaggccatc cgtcaggatg gccttctgct     3420

tagtttgatg cctggcagtt tatggcgggc gtcctgcccg ccaccctccg ggccgttgct     3480

tcacaacgtt caaatccgct cccggcggat ttgtcctact caggagagcg ttcaccgaca     3540

aacaacagat aaaacgaaag gcccagtctt ccgactgagc ctttcgtttt atttgatgcc     3600

tggcagttcc ctactctcgc gttaacgcta gcatggatgt tttcccagtc acgacgttgt     3660

aaaacgacgg ccagtcttaa gctcgggccc caaataatga ttttattttg actgatagtg     3720

acctgttcgt tgcaacaaat tgatgagcaa tgctttttta taatgccaac tttgtacaaa     3780

aaagcaggct ccgcggccgc cccctt                                          3806


