Sequence List

<110> Suzhou Galaxy Biopharma, CO., LTD. 

<120> A novel neutralizing human monoclonal antibody 8D6 against HCV infection   

<140>

<160> 16

<170> 

<210> 1 

<211> 379

<212> DNA 

<213> Homo sapiens

<220> 

<221> V_region

<222> (1)...(379) 

<400> 1 

gaggtgcagc tggtgcagtc tgggtctgag ttgaagaagc ctggggcctc actgaagctc 60
tcctgcaagg cttctggata cacctacatt acccctgcca tgaactgggt gcgacaggcc 120
cctggacatg ggcttgagtg gatgggagga atcaacacca acactgggaa cccaacctat 180
gcccagggct tcgcaggacg gtttgtcttc tcctgggaca cctctgtcag cacggcatat 240
ctgcatatca gcagcctaaa gactgaggac actgccgtct attactgtgc ggacacccga 320
atcttttctt gtcggcgtgg aacgtgctat ggtggtttcg atgtctgggg ccaagggaca 380
atggtcaccg tctcttcag 379

<210> 2 

<211> 126

<212> DNA 

<213> Homo sapiens

<220> 

<221> V_region

<222> (1)...(126) 

<400> 2

Glu Val Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ala 
1            	 5                  10                  15
Ser Leu Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Tyr Ile Thr Pro
            20                  25                  30
Ala Met Asn Trp Val Arg Gln Ala Pro Gly His Gly Leu Glu Trp Met 
        35                  40                  45
Gly Gly Ile Asn Thr Asn Thr Gly Asn Pro Thr Tyr Ala Gln Gly Phe 
    50                  55                  60
Ala Gly Arg Phe Val Phe Ser Trp Asp Thr Ser Val Ser Thr Ala Tyr
65                  70                  75                  80
Leu His Ile Ser Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95
Ala Asp Thr Arg Ile Phe Ser Cys Arg Arg Gly Thr Cys Tyr Gly Gly 
            100                 105                 110
Phe Asp Val Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        105                 110                 115

<210> 3 

<211> 322

<212> DNA 

<213> Homo sapiens

<220> 

<221> V_region

<222> (1)...(322) 

<400> 3

gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagaatcacc 60
atcacttgcc gggcaagtca gagcattagc aactttttaa attggtttca gcatagaccg 120
gggaaagccc ctaaactcct gatctatggt gcaaccattt tgcaaagtgg ggtcccatca 180
aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240
gaagattttg caacttacta ctgtcaacag agtgacagta gtacctacat ctttggccag 300
gggaccaagg tggaaatcaa ac 322

<210> 4 

<211> 107

<212> DNA 

<213> Homo sapiens

<220> 

<221> V_region

<222> (1)...(107) 

<400> 4

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1            	 5                  10                  15
Asp Arg Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Asn Phe 
            20                  25                  30
Leu Asn Trp Phe Gln His Arg Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45
Tyr Gly Ala Thr Ile Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                   55                 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Asp Ser Ser Thr Tyr 
                85                  90                  95
Ile Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
            100                 105

<210> 5 

<211> 15

<212> DNA 

<213> Homo sapiens

<220> 

<221> V_region

<222> (1)...(15) 

<400> 5

acccctgcca tgaac 15
<210> 6 

<211> 51

<212> DNA 

<213> Homo sapiens

<220> 

<221> V_region

<222> (1)...(51) 

<400> 6

ggaatcaaca ccaacactgg gaacccaacc tatgcccagg gcttcgcagg a 51

<210> 7 

<211> 57

<212> DNA 

<213> Homo sapiens

<220> 

<221> V_region

<222> (1)...(57) 

<400> 7

gcggacaccc gaatcttttc ttgtcggcgt ggaacgtgct atggtggttt cgatgtc 57

<210> 8 

<211> 5

<212> DNA 

<213> Homo sapiens

<220> 

<221> V_region

<222> (1)...(5) 

<400> 8

Thr Pro Ala Met Asn
1                5

<210> 9 

<211> 17

<212> DNA 

<213> Homo sapiens

<220> 

<221> V_region

<222> (1)...(17) 

<400> 9

Gly Ile Asn Thr Asn Thr Gly Asn Pro Thr Tyr Ala Gln Gly Phe Ala
1                5                  10                  15
Gly

<210> 10 

<211> 19

<212> DNA 

<213> Homo sapiens

<220> 

<221> V_region

<222> (1)...(19) 

<400> 10

Ala Asp Thr Arg Ile Phe Ser Cys Arg Arg Gly Thr Cys Tyr Gly Gly
1            	 5                  10                  15
Phe Asp Val

<210> 11 

<211> 33

<212> DNA 

<213> Homo sapiens

<220> 

<221> V_region

<222> (1)...(33) 

<400> 11

cgggcaagtc agagcattag caacttttta aat 33

<210> 12 

<211> 21

<212> DNA 

<213> Homo sapiens

<220> 

<221> V_region

<222> (1)...(21) 

<400> 12

ggtgcaacca ttttgcaaag t 21

<210> 13 

<211> 27

<212> DNA 

<213> Homo sapiens

<220> 

<221> V_region

<222> (1)...(27) 

<400> 13

caacagagtg acagtagtac ctacatc 27

<210> 14 

<211> 11

<212> DNA 

<213> Homo sapiens

<220> 

<221> V_region

<222> (1)...(11) 

<400> 14

Arg Ala Ser Gln Ser Ile Ser Asn Phe Leu Asn
1                5                  10

<210> 15 

<211> 7

<212> DNA 

<213> Homo sapiens

<220> 

<221> V_region

<222> (1)...(7) 

<400> 15

Gly Ala Thr Ile Leu Gln Ser
1                5

<210> 16 

<211> 9

<212> DNA 

<213> Homo sapiens

<220> 

<221> V_region

<222> (1)...(9) 

<400> 16

Gln Gln Ser Asp Ser Ser Thr Tyr Ile
1                5     
