                               SEQUENCE LISTING

<110> ETUBICS CORPORATION
 
<120> NEOEPITOPE VACCINE COMPOSITIONS AND METHODS OF USE THEREOF

<130> 39891-723.601

<140> PCT/US2017/034802
<141> 2017-05-26

<150> 62/342,752
<151> 2016-05-27

<160> 112   

<170> PatentIn version 3.5

<210> 1
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 1
Gly Glu Thr Val Thr Met Pro Cys Pro 
1               5                   


<210> 2
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 2
Val Gly Pro Val Asn Pro Ser His Arg 
1               5                   


<210> 3
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 3
Gly Leu Gly Ala Gln Cys Ser Glu Ala 
1               5                   


<210> 4
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 4
Arg Lys Leu Thr Thr Glu Leu Thr Ile 
1               5                   


<210> 5
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 5
Pro Glu Arg Arg Lys Leu Thr Thr Glu 
1               5                   


<210> 6
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 6
Met Asp Trp Val Trp Met Asp Thr Thr 
1               5                   


<210> 7
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 7
Val Trp Met Asp Thr Thr Leu Ser Leu 
1               5                   


<210> 8
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 8
Gly Lys Thr Leu Asn Pro Ser Gln Thr 
1               5                   


<210> 9
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 9
Arg Glu Gly Lys Thr Leu Asn Pro Ser 
1               5                   


<210> 10
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 10
Val Arg Asn Ala Thr Ser Tyr Arg Cys 
1               5                   


<210> 11
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 11
Asn Val Thr Val Arg Asn Ala Thr Ser 
1               5                   


<210> 12
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 12
Phe Ala Met Ala Gln Ile Pro Ser Leu 
1               5                   


<210> 13
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 13
Ala Gln Ile Pro Ser Leu Ser Leu Arg 
1               5                   


<210> 14
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 14
Pro Phe Ala Met Ala Gln Ile Pro Ser Leu Ser Leu Arg Ala Val 
1               5                   10                  15  


<210> 15
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 15
Leu Pro Asn Val Thr Val Arg Asn Ala Thr Ser Tyr Arg Cys Gly 
1               5                   10                  15  


<210> 16
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 16
Ser Trp Phe Arg Glu Gly Lys Thr Leu Asn Pro Ser Gln Thr Ser 
1               5                   10                  15  


<210> 17
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 17
Ala Val Met Asp Trp Val Trp Met Asp Thr Thr Leu Ser Leu Ser 
1               5                   10                  15  


<210> 18
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 18
Leu Gly Pro Glu Arg Arg Lys Leu Thr Thr Glu Leu Thr Ile Ile 
1               5                   10                  15  


<210> 19
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 19
Asn Asn Gly Leu Gly Ala Gln Cys Ser Glu Ala Val Thr Leu Asn 
1               5                   10                  15  


<210> 20
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 20
Asn Val Gly Glu Thr Val Thr Met Pro Cys Pro Lys Val Phe Ser 
1               5                   10                  15  


<210> 21
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 21
Glu Gln Val Trp Gly Met Ala Val Arg 
1               5                   


<210> 22
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 22
Cys Gln Gly Pro Glu Gln Val Trp Gly Met Ala Val Arg Glu Leu 
1               5                   10                  15  


<210> 23
<211> 45
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 23
cccttcgcca tggcccagat ccccagcctg agcctgaggg ccgtg                       45


<210> 24
<211> 45
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 24
ctgcccaacg tgaccgtgag gaacgccacc agctacaggt gcggc                       45


<210> 25
<211> 45
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 25
agctggttca gggagggcaa gaccctgaac cccagccaga ccagc                       45


<210> 26
<211> 45
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 26
gccgtgatgg actgggtgtg gatggacacc accctgagcc tgagc                       45


<210> 27
<211> 45
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 27
ctgggccccg agaggaggaa gctgaccacc gagctgacca tcatc                       45


<210> 28
<211> 45
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 28
aacaacggcc tgggcgccca gtgcagcgag gccgtgaccc tgaac                       45


<210> 29
<211> 45
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 29
aacgtgggcg agaccgtgac catgccctgc cccaaggtgt tcagc                       45


<210> 30
<211> 45
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 30
tgccagggcc ccgagcaggt gtggggcatg gccgtgaggg agctg                       45


<210> 31
<211> 402
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 31
ctcgaggaag cttgccgcca ccatgccatt tgccatggcc cagatcccca gcctgagcct       60

gagagctgtg ctgcctaatg tgaccgtgcg gaacgccacc agctacagat gtggcagctg      120

gttcagagag ggcaagaccc tgaaccccag ccagaccagc gccgtgatgg actgggtgtg      180

gatggacacc accctgtccc tgagcctggg ccccgagaga agaaagctga ccaccgagct      240

gacaatcatc aacaatggcc tgggcgctca gtgtagcgag gccgtgaccc tgaataatgt      300

gggcgagaca gtgaccatgc cctgccccaa ggtgttcagc tgccagggcc ccgaacaagt      360

gtggggaatg gctgtgcgcg agctgtgaga tatcgcggcc gc                         402


<210> 32
<211> 591
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 32
ctcgaggaag cttgccgcca ccatgccatt tgccatggcc cagatcccca gcctgagcct       60

gagagctgtg ggaagcggga gtggctcagg ttcaggactg cctaatgtga ccgtgcggaa      120

cgccaccagc tacagatgtg gcggaagtgg gtcaggctcc ggttctggaa gctggttcag      180

agagggcaag accctgaacc ccagccagac cagcgggtca ggaagtggta gcggctccgg      240

ggccgtgatg gactgggtgt ggatggacac caccctgtcc ctgagcggaa gtggatcagg      300

ttccggctct gggctgggcc ccgagagaag aaagctgacc accgagctga caatcatcgg      360

atccgggtct ggcagtggtt caggcaacaa tggcctgggc gctcagtgta gcgaggccgt      420

gaccctgaat ggatcagggt ccggcagcgg tagtggcaat gtgggcgaga cagtgaccat      480

gccctgcccc aaggtgttca gcgggtccgg atctggtagt ggctcaggtt gccagggccc      540

cgaacaagtg tggggaatgg ctgtgcgcga gctgtgagat atcgcggccg c               591


<210> 33
<211> 642
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 33
ctcgaggaag cttgccgcca ccatgcctag cgagagccct ccatttgcca tggcccagat       60

ccccagcctg agcctgagag ctgtgtctgg cgctatggga gcccacagca tccccctgcc      120

taatgtgacc gtgcggaacg ccaccagcta cagatgtggc gtgggacctc ctggccctcc      180

tgcttccctg agctggttca gagagggcaa gaccctgaac cccagccaga ccagcatgag      240

cggcaccctg ctgacagagc tgagagccgt gatggactgg gtgtggatgg acaccaccct      300

gtccctgagc agctggatct gtgtggtgtc cgccacagac ctgggccccg agagaagaaa      360

gctgaccacc gagctgacaa tcatcctgca gggcctggac tacagctgcg aggccaacaa      420

tggcctgggc gctcagtgta gcgaggccgt gaccctgaat ttcaccgtgc ccacctgttg      480

gaggcccgcc aatgtgggcg agacagtgac catgccctgc cccaaggtgt tcagcaactt      540

ctacagcaaa gtgcggggct tcatgtgcca gggccccgaa caagtgtggg gaatggctgt      600

gcgcgagctg aacatgaacc tgctgtgaga tatcgcggcc gc                         642


<210> 34
<211> 831
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 34
ctcgaggaag cttgccgcca ccatgcctag cgagagccct ccatttgcca tggcccagat       60

ccccagcctg agcctgagag ctgtgtctgg cgctatggga ggaagcggga gtggctcagg      120

ttcaggagcc cacagcatcc ccctgcctaa tgtgaccgtg cggaacgcca ccagctacag      180

atgtggcgtg ggacctcctg gcggaagtgg gtcaggctcc ggttctggac ctcctgcttc      240

cctgagctgg ttcagagagg gcaagaccct gaaccccagc cagaccagca tgagcggcac      300

cctggggtca ggaagtggta gcggctccgg gctgacagag ctgagagccg tgatggactg      360

ggtgtggatg gacaccaccc tgtccctgag cagctggatc tgtgtgggaa gtggatcagg      420

ttccggctct ggggtgtccg ccacagacct gggccccgag agaagaaagc tgaccaccga      480

gctgacaatc atcctgcagg gcctggacgg atccgggtct ggcagtggtt caggctacag      540

ctgcgaggcc aacaatggcc tgggcgctca gtgtagcgag gccgtgaccc tgaatttcac      600

cgtgcccacc ggatcagggt ccggcagcgg tagtggctgt tggaggcccg ccaatgtggg      660

cgagacagtg accatgccct gccccaaggt gttcagcaac ttctacagca aagggtccgg      720

atctggtagt ggctcaggtg tgcggggctt catgtgccag ggccccgaac aagtgtgggg      780

aatggctgtg cgcgagctga acatgaacct gctgtgagat atcgcggccg c               831


<210> 35
<211> 121
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 35
Met Pro Phe Ala Met Ala Gln Ile Pro Ser Leu Ser Leu Arg Ala Val 
1               5                   10                  15      


Leu Pro Asn Val Thr Val Arg Asn Ala Thr Ser Tyr Arg Cys Gly Ser 
            20                  25                  30          


Trp Phe Arg Glu Gly Lys Thr Leu Asn Pro Ser Gln Thr Ser Ala Val 
        35                  40                  45              


Met Asp Trp Val Trp Met Asp Thr Thr Leu Ser Leu Ser Leu Gly Pro 
    50                  55                  60                  


Glu Arg Arg Lys Leu Thr Thr Glu Leu Thr Ile Ile Asn Asn Gly Leu 
65                  70                  75                  80  


Gly Ala Gln Cys Ser Glu Ala Val Thr Leu Asn Asn Val Gly Glu Thr 
                85                  90                  95      


Val Thr Met Pro Cys Pro Lys Val Phe Ser Cys Gln Gly Pro Glu Gln 
            100                 105                 110         


Val Trp Gly Met Ala Val Arg Glu Leu 
        115                 120     


<210> 36
<211> 184
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 36
Met Pro Phe Ala Met Ala Gln Ile Pro Ser Leu Ser Leu Arg Ala Val 
1               5                   10                  15      


Gly Ser Gly Ser Gly Ser Gly Ser Gly Leu Pro Asn Val Thr Val Arg 
            20                  25                  30          


Asn Ala Thr Ser Tyr Arg Cys Gly Gly Ser Gly Ser Gly Ser Gly Ser 
        35                  40                  45              


Gly Ser Trp Phe Arg Glu Gly Lys Thr Leu Asn Pro Ser Gln Thr Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Ser Gly Ser Gly Ala Val Met Asp Trp Val Trp 
65                  70                  75                  80  


Met Asp Thr Thr Leu Ser Leu Ser Gly Ser Gly Ser Gly Ser Gly Ser 
                85                  90                  95      


Gly Leu Gly Pro Glu Arg Arg Lys Leu Thr Thr Glu Leu Thr Ile Ile 
            100                 105                 110         


Gly Ser Gly Ser Gly Ser Gly Ser Gly Asn Asn Gly Leu Gly Ala Gln 
        115                 120                 125             


Cys Ser Glu Ala Val Thr Leu Asn Gly Ser Gly Ser Gly Ser Gly Ser 
    130                 135                 140                 


Gly Asn Val Gly Glu Thr Val Thr Met Pro Cys Pro Lys Val Phe Ser 
145                 150                 155                 160 


Gly Ser Gly Ser Gly Ser Gly Ser Gly Cys Gln Gly Pro Glu Gln Val 
                165                 170                 175     


Trp Gly Met Ala Val Arg Glu Leu 
            180                 


<210> 37
<211> 201
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 37
Met Pro Ser Glu Ser Pro Pro Phe Ala Met Ala Gln Ile Pro Ser Leu 
1               5                   10                  15      


Ser Leu Arg Ala Val Ser Gly Ala Met Gly Ala His Ser Ile Pro Leu 
            20                  25                  30          


Pro Asn Val Thr Val Arg Asn Ala Thr Ser Tyr Arg Cys Gly Val Gly 
        35                  40                  45              


Pro Pro Gly Pro Pro Ala Ser Leu Ser Trp Phe Arg Glu Gly Lys Thr 
    50                  55                  60                  


Leu Asn Pro Ser Gln Thr Ser Met Ser Gly Thr Leu Leu Thr Glu Leu 
65                  70                  75                  80  


Arg Ala Val Met Asp Trp Val Trp Met Asp Thr Thr Leu Ser Leu Ser 
                85                  90                  95      


Ser Trp Ile Cys Val Val Ser Ala Thr Asp Leu Gly Pro Glu Arg Arg 
            100                 105                 110         


Lys Leu Thr Thr Glu Leu Thr Ile Ile Leu Gln Gly Leu Asp Tyr Ser 
        115                 120                 125             


Cys Glu Ala Asn Asn Gly Leu Gly Ala Gln Cys Ser Glu Ala Val Thr 
    130                 135                 140                 


Leu Asn Phe Thr Val Pro Thr Cys Trp Arg Pro Ala Asn Val Gly Glu 
145                 150                 155                 160 


Thr Val Thr Met Pro Cys Pro Lys Val Phe Ser Asn Phe Tyr Ser Lys 
                165                 170                 175     


Val Arg Gly Phe Met Cys Gln Gly Pro Glu Gln Val Trp Gly Met Ala 
            180                 185                 190         


Val Arg Glu Leu Asn Met Asn Leu Leu 
        195                 200     


<210> 38
<211> 264
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 38
Met Pro Ser Glu Ser Pro Pro Phe Ala Met Ala Gln Ile Pro Ser Leu 
1               5                   10                  15      


Ser Leu Arg Ala Val Ser Gly Ala Met Gly Gly Ser Gly Ser Gly Ser 
            20                  25                  30          


Gly Ser Gly Ala His Ser Ile Pro Leu Pro Asn Val Thr Val Arg Asn 
        35                  40                  45              


Ala Thr Ser Tyr Arg Cys Gly Val Gly Pro Pro Gly Gly Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Pro Pro Ala Ser Leu Ser Trp Phe Arg Glu Gly 
65                  70                  75                  80  


Lys Thr Leu Asn Pro Ser Gln Thr Ser Met Ser Gly Thr Leu Gly Ser 
                85                  90                  95      


Gly Ser Gly Ser Gly Ser Gly Leu Thr Glu Leu Arg Ala Val Met Asp 
            100                 105                 110         


Trp Val Trp Met Asp Thr Thr Leu Ser Leu Ser Ser Trp Ile Cys Val 
        115                 120                 125             


Gly Ser Gly Ser Gly Ser Gly Ser Gly Val Ser Ala Thr Asp Leu Gly 
    130                 135                 140                 


Pro Glu Arg Arg Lys Leu Thr Thr Glu Leu Thr Ile Ile Leu Gln Gly 
145                 150                 155                 160 


Leu Asp Gly Ser Gly Ser Gly Ser Gly Ser Gly Tyr Ser Cys Glu Ala 
                165                 170                 175     


Asn Asn Gly Leu Gly Ala Gln Cys Ser Glu Ala Val Thr Leu Asn Phe 
            180                 185                 190         


Thr Val Pro Thr Gly Ser Gly Ser Gly Ser Gly Ser Gly Cys Trp Arg 
        195                 200                 205             


Pro Ala Asn Val Gly Glu Thr Val Thr Met Pro Cys Pro Lys Val Phe 
    210                 215                 220                 


Ser Asn Phe Tyr Ser Lys Gly Ser Gly Ser Gly Ser Gly Ser Gly Val 
225                 230                 235                 240 


Arg Gly Phe Met Cys Gln Gly Pro Glu Gln Val Trp Gly Met Ala Val 
                245                 250                 255     


Arg Glu Leu Asn Met Asn Leu Leu 
            260                 


<210> 39
<211> 132
<212> PRT
<213> Mycobacterium tuberculosis

<400> 39
Thr Ala Ala Ser Asp Asn Phe Gln Leu Ser Gln Gly Gly Gln Gly Phe 
1               5                   10                  15      


Ala Ile Pro Ile Gly Gln Ala Met Ala Ile Ala Gly Gln Ile Arg Ser 
            20                  25                  30          


Gly Gly Gly Ser Pro Thr Val His Ile Gly Pro Thr Ala Phe Leu Gly 
        35                  40                  45              


Leu Gly Val Val Asp Asn Asn Gly Asn Gly Ala Arg Val Gln Arg Val 
    50                  55                  60                  


Val Gly Ser Ala Pro Ala Ala Ser Leu Gly Ile Ser Thr Gly Asp Val 
65                  70                  75                  80  


Ile Thr Ala Val Asp Gly Ala Pro Ile Asn Ser Ala Thr Ala Met Ala 
                85                  90                  95      


Asp Ala Leu Asn Gly His His Pro Gly Asp Val Ile Ser Val Thr Trp 
            100                 105                 110         


Gln Thr Lys Ser Gly Gly Thr Arg Thr Gly Asn Val Thr Leu Ala Glu 
        115                 120                 125             


Gly Pro Pro Ala 
    130         


<210> 40
<211> 230
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 40
Met His His His His His His Thr Ala Ala Ser Asp Asn Phe Gln Leu 
1               5                   10                  15      


Ser Gln Gly Gly Gln Gly Phe Ala Ile Pro Ile Gly Gln Ala Met Ala 
            20                  25                  30          


Ile Ala Gly Gln Ile Arg Ser Gly Gly Gly Ser Pro Thr Val His Ile 
        35                  40                  45              


Gly Pro Thr Ala Phe Leu Gly Leu Gly Val Val Asp Asn Asn Gly Asn 
    50                  55                  60                  


Gly Ala Arg Val Gln Arg Val Val Gly Ser Ala Pro Ala Ala Ser Leu 
65                  70                  75                  80  


Gly Ile Ser Thr Gly Asp Val Ile Thr Ala Val Asp Gly Ala Pro Ile 
                85                  90                  95      


Asn Ser Ala Thr Ala Met Ala Asp Ala Leu Asn Gly His His Pro Gly 
            100                 105                 110         


Asp Val Ile Ser Val Thr Trp Gln Thr Lys Ser Gly Gly Thr Arg Thr 
        115                 120                 125             


Gly Asn Val Thr Leu Ala Glu Gly Pro Pro Ala Glu Phe Asp Asp Asp 
    130                 135                 140                 


Asp Lys Asp Pro Pro Asp Pro His Gln Pro Asp Met Thr Lys Gly Tyr 
145                 150                 155                 160 


Cys Pro Gly Gly Arg Trp Gly Phe Gly Asp Leu Ala Val Cys Asp Gly 
                165                 170                 175     


Glu Lys Tyr Pro Asp Gly Ser Phe Trp His Gln Trp Met Gln Thr Trp 
            180                 185                 190         


Phe Thr Gly Pro Gln Phe Tyr Phe Asp Cys Val Ser Gly Gly Glu Pro 
        195                 200                 205             


Leu Pro Gly Pro Pro Pro Pro Gly Gly Cys Gly Gly Ala Ile Pro Ser 
    210                 215                 220                 


Glu Gln Pro Asn Ala Pro 
225                 230 


<210> 41
<211> 578
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 41
Met His His His His His His Thr Ala Ala Ser Asp Asn Phe Gln Leu 
1               5                   10                  15      


Ser Gln Gly Gly Gln Gly Phe Ala Ile Pro Ile Gly Gln Ala Met Ala 
            20                  25                  30          


Ile Ala Gly Gln Ile Arg Ser Gly Gly Gly Ser Pro Thr Val His Ile 
        35                  40                  45              


Gly Pro Thr Ala Phe Leu Gly Leu Gly Val Val Asp Asn Asn Gly Asn 
    50                  55                  60                  


Gly Ala Arg Val Gln Arg Val Val Gly Ser Ala Pro Ala Ala Ser Leu 
65                  70                  75                  80  


Gly Ile Ser Thr Gly Asp Val Ile Thr Ala Val Asp Gly Ala Pro Ile 
                85                  90                  95      


Asn Ser Ala Thr Ala Met Ala Asp Ala Leu Asn Gly His His Pro Gly 
            100                 105                 110         


Asp Val Ile Ser Val Thr Trp Gln Thr Lys Ser Gly Gly Thr Arg Thr 
        115                 120                 125             


Gly Asn Val Thr Leu Ala Glu Gly Pro Pro Ala Glu Phe Pro Leu Val 
    130                 135                 140                 


Pro Arg Gly Ser Pro Met Gly Ser Asp Val Arg Asp Leu Asn Ala Leu 
145                 150                 155                 160 


Leu Pro Ala Val Pro Ser Leu Gly Gly Gly Gly Gly Cys Ala Leu Pro 
                165                 170                 175     


Val Ser Gly Ala Ala Gln Trp Ala Pro Val Leu Asp Phe Ala Pro Pro 
            180                 185                 190         


Gly Ala Ser Ala Tyr Gly Ser Leu Gly Gly Pro Ala Pro Pro Pro Ala 
        195                 200                 205             


Pro Pro Pro Pro Pro Pro Pro Pro Pro His Ser Phe Ile Lys Gln Glu 
    210                 215                 220                 


Pro Ser Trp Gly Gly Ala Glu Pro His Glu Glu Gln Cys Leu Ser Ala 
225                 230                 235                 240 


Phe Thr Val His Phe Ser Gly Gln Phe Thr Gly Thr Ala Gly Ala Cys 
                245                 250                 255     


Arg Tyr Gly Pro Phe Gly Pro Pro Pro Pro Ser Gln Ala Ser Ser Gly 
            260                 265                 270         


Gln Ala Arg Met Phe Pro Asn Ala Pro Tyr Leu Pro Ser Cys Leu Glu 
        275                 280                 285             


Ser Gln Pro Ala Ile Arg Asn Gln Gly Tyr Ser Thr Val Thr Phe Asp 
    290                 295                 300                 


Gly Thr Pro Ser Tyr Gly His Thr Pro Ser His His Ala Ala Gln Phe 
305                 310                 315                 320 


Pro Asn His Ser Phe Lys His Glu Asp Pro Met Gly Gln Gln Gly Ser 
                325                 330                 335     


Leu Gly Glu Gln Gln Tyr Ser Val Pro Pro Pro Val Tyr Gly Cys His 
            340                 345                 350         


Thr Pro Thr Asp Ser Cys Thr Gly Ser Gln Ala Leu Leu Leu Arg Thr 
        355                 360                 365             


Pro Tyr Ser Ser Asp Asn Leu Tyr Gln Met Thr Ser Gln Leu Glu Cys 
    370                 375                 380                 


Met Thr Trp Asn Gln Met Asn Leu Gly Ala Thr Leu Lys Gly His Ser 
385                 390                 395                 400 


Thr Gly Tyr Glu Ser Asp Asn His Thr Thr Pro Ile Leu Cys Gly Ala 
                405                 410                 415     


Gln Tyr Arg Ile His Thr His Gly Val Phe Arg Gly Ile Gln Asp Val 
            420                 425                 430         


Arg Arg Val Pro Gly Val Ala Pro Thr Leu Val Arg Ser Ala Ser Glu 
        435                 440                 445             


Thr Ser Glu Lys Arg Pro Phe Met Cys Ala Tyr Ser Gly Cys Asn Lys 
    450                 455                 460                 


Arg Tyr Phe Lys Leu Ser His Leu Gln Met His Ser Arg Lys His Thr 
465                 470                 475                 480 


Gly Glu Lys Pro Tyr Gln Cys Asp Phe Lys Asp Cys Glu Arg Arg Phe 
                485                 490                 495     


Phe Arg Ser Asp Gln Leu Lys Arg His Gln Arg Arg His Thr Gly Val 
            500                 505                 510         


Lys Pro Phe Gln Cys Lys Thr Cys Gln Arg Lys Phe Ser Arg Ser Asp 
        515                 520                 525             


His Leu Lys Thr His Thr Arg Thr His Thr Gly Glu Lys Pro Phe Ser 
    530                 535                 540                 


Cys Arg Trp Pro Ser Cys Gln Lys Lys Phe Ala Arg Ser Asp Glu Leu 
545                 550                 555                 560 


Val Arg His His Asn Met His Gln Arg Asn Met Thr Lys Leu Gln Leu 
                565                 570                 575     


Ala Leu 
        


<210> 42
<211> 220
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 42
Met His His His His His His Thr Ala Ala Ser Asp Asn Phe Gln Leu 
1               5                   10                  15      


Ser Gln Gly Gly Gln Gly Phe Ala Ile Pro Ile Gly Gln Ala Met Ala 
            20                  25                  30          


Ile Ala Gly Gln Ile Arg Ser Gly Gly Gly Ser Pro Thr Val His Ile 
        35                  40                  45              


Gly Pro Thr Ala Phe Leu Gly Leu Gly Val Val Asp Asn Asn Gly Asn 
    50                  55                  60                  


Gly Ala Arg Val Gln Arg Val Val Gly Ser Ala Pro Ala Ala Ser Leu 
65                  70                  75                  80  


Gly Ile Ser Thr Gly Asp Val Ile Thr Ala Val Asp Gly Ala Pro Ile 
                85                  90                  95      


Asn Ser Ala Thr Ala Met Ala Asp Ala Leu Asn Gly His His Pro Gly 
            100                 105                 110         


Asp Val Ile Ser Val Thr Trp Gln Thr Lys Ser Gly Gly Thr Arg Thr 
        115                 120                 125             


Gly Asn Val Thr Leu Ala Glu Gly Pro Pro Ala Glu Phe Ile Glu Gly 
    130                 135                 140                 


Arg Gly Ser Gly Cys Pro Leu Leu Glu Asn Val Ile Ser Lys Thr Ile 
145                 150                 155                 160 


Asn Pro Gln Val Ser Lys Thr Glu Tyr Lys Glu Leu Leu Gln Glu Phe 
                165                 170                 175     


Ile Asp Asp Asn Ala Thr Thr Asn Ala Ile Asp Glu Leu Lys Glu Cys 
            180                 185                 190         


Phe Leu Asn Gln Thr Asp Glu Thr Leu Ser Asn Val Glu Val Phe Met 
        195                 200                 205             


Gln Leu Ile Tyr Asp Ser Ser Leu Cys Asp Leu Phe 
    210                 215                 220 


<210> 43
<211> 729
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 43
Met His His His His His His Thr Ala Ala Ser Asp Asn Phe Gln Leu 
1               5                   10                  15      


Ser Gln Gly Gly Gln Gly Phe Ala Ile Pro Ile Gly Gln Ala Met Ala 
            20                  25                  30          


Ile Ala Gly Gln Ile Arg Ser Gly Gly Gly Ser Pro Thr Val His Ile 
        35                  40                  45              


Gly Pro Thr Ala Phe Leu Gly Leu Gly Val Val Asp Asn Asn Gly Asn 
    50                  55                  60                  


Gly Ala Arg Val Gln Arg Val Val Gly Ser Ala Pro Ala Ala Ser Leu 
65                  70                  75                  80  


Gly Ile Ser Thr Gly Asp Val Ile Thr Ala Val Asp Gly Ala Pro Ile 
                85                  90                  95      


Asn Ser Ala Thr Ala Met Ala Asp Ala Leu Asn Gly His His Pro Gly 
            100                 105                 110         


Asp Val Ile Ser Val Thr Trp Gln Thr Lys Ser Gly Gly Thr Arg Thr 
        115                 120                 125             


Gly Asn Val Thr Leu Ala Glu Gly Pro Pro Ala Glu Phe Met Val Asp 
    130                 135                 140                 


Phe Gly Ala Leu Pro Pro Glu Ile Asn Ser Ala Arg Met Tyr Ala Gly 
145                 150                 155                 160 


Pro Gly Ser Ala Ser Leu Val Ala Ala Ala Gln Met Trp Asp Ser Val 
                165                 170                 175     


Ala Ser Asp Leu Phe Ser Ala Ala Ser Ala Phe Gln Ser Val Val Trp 
            180                 185                 190         


Gly Leu Thr Val Gly Ser Trp Ile Gly Ser Ser Ala Gly Leu Met Val 
        195                 200                 205             


Ala Ala Ala Ser Pro Tyr Val Ala Trp Met Ser Val Thr Ala Gly Gln 
    210                 215                 220                 


Ala Glu Leu Thr Ala Ala Gln Val Arg Val Ala Ala Ala Ala Tyr Glu 
225                 230                 235                 240 


Thr Ala Tyr Gly Leu Thr Val Pro Pro Pro Val Ile Ala Glu Asn Arg 
                245                 250                 255     


Ala Glu Leu Met Ile Leu Ile Ala Thr Asn Leu Leu Gly Gln Asn Thr 
            260                 265                 270         


Pro Ala Ile Ala Val Asn Glu Ala Glu Tyr Gly Glu Met Trp Ala Gln 
        275                 280                 285             


Asp Ala Ala Ala Met Phe Gly Tyr Ala Ala Ala Thr Ala Thr Ala Thr 
    290                 295                 300                 


Ala Thr Leu Leu Pro Phe Glu Glu Ala Pro Glu Met Thr Ser Ala Gly 
305                 310                 315                 320 


Gly Leu Leu Glu Gln Ala Ala Ala Val Glu Glu Ala Ser Asp Thr Ala 
                325                 330                 335     


Ala Ala Asn Gln Leu Met Asn Asn Val Pro Gln Ala Leu Gln Gln Leu 
            340                 345                 350         


Ala Gln Pro Thr Gln Gly Thr Thr Pro Ser Ser Lys Leu Gly Gly Leu 
        355                 360                 365             


Trp Lys Thr Val Ser Pro His Arg Ser Pro Ile Ser Asn Met Val Ser 
    370                 375                 380                 


Met Ala Asn Asn His Met Ser Met Thr Asn Ser Gly Val Ser Met Thr 
385                 390                 395                 400 


Asn Thr Leu Ser Ser Met Leu Lys Gly Phe Ala Pro Ala Ala Ala Ala 
                405                 410                 415     


Gln Ala Val Gln Thr Ala Ala Gln Asn Gly Val Arg Ala Met Ser Ser 
            420                 425                 430         


Leu Gly Ser Ser Leu Gly Ser Ser Gly Leu Gly Gly Gly Val Ala Ala 
        435                 440                 445             


Asn Leu Gly Arg Ala Ala Ser Val Gly Ser Leu Ser Val Pro Gln Ala 
    450                 455                 460                 


Trp Ala Ala Ala Asn Gln Ala Val Thr Pro Ala Ala Arg Ala Leu Pro 
465                 470                 475                 480 


Leu Thr Ser Leu Thr Ser Ala Ala Glu Arg Gly Pro Gly Gln Met Leu 
                485                 490                 495     


Gly Gly Leu Pro Val Gly Gln Met Gly Ala Arg Ala Gly Gly Gly Leu 
            500                 505                 510         


Ser Gly Val Leu Arg Val Pro Pro Arg Pro Tyr Val Met Pro His Ser 
        515                 520                 525             


Pro Ala Ala Gly Asp Ile Ala Pro Pro Ala Leu Ser Gln Asp Arg Phe 
    530                 535                 540                 


Ala Asp Phe Pro Ala Leu Pro Leu Asp Pro Ser Ala Met Val Ala Gln 
545                 550                 555                 560 


Val Gly Pro Gln Val Val Asn Ile Asn Thr Lys Leu Gly Tyr Asn Asn 
                565                 570                 575     


Ala Val Gly Ala Gly Thr Gly Ile Val Ile Asp Pro Asn Gly Val Val 
            580                 585                 590         


Leu Thr Asn Asn His Val Ile Ala Gly Ala Thr Asp Ile Asn Ala Phe 
        595                 600                 605             


Ser Val Gly Ser Gly Gln Thr Tyr Gly Val Asp Val Val Gly Tyr Asp 
    610                 615                 620                 


Arg Thr Gln Asp Val Ala Val Leu Gln Leu Arg Gly Ala Gly Gly Leu 
625                 630                 635                 640 


Pro Ser Ala Ala Ile Gly Gly Gly Val Ala Val Gly Glu Pro Val Val 
                645                 650                 655     


Ala Met Gly Asn Ser Gly Gly Gln Gly Gly Thr Pro Arg Ala Val Pro 
            660                 665                 670         


Gly Arg Val Val Ala Leu Gly Gln Thr Val Gln Ala Ser Asp Ser Leu 
        675                 680                 685             


Thr Gly Ala Glu Glu Thr Leu Asn Gly Leu Ile Gln Phe Asp Ala Ala 
    690                 695                 700                 


Ile Gln Pro Gly Asp Ser Gly Gly Pro Val Val Asn Gly Leu Gly Gln 
705                 710                 715                 720 


Val Val Gly Met Asn Thr Ala Ala Ser 
                725                 


<210> 44
<211> 30
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 44
Thr Ala Ala Ser Asp Asn Phe Gln Leu Ser Gln Gly Gly Gln Gly Phe 
1               5                   10                  15      


Ala Ile Pro Ile Gly Gln Ala Met Ala Ile Ala Gly Gln Ile 
            20                  25                  30  


<210> 45
<211> 128
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 45
Thr Ala Ala Ser Asp Asn Phe Gln Leu Ser Gln Gly Gly Gln Gly Phe 
1               5                   10                  15      


Ala Ile Pro Ile Gly Gln Ala Met Ala Ile Ala Gly Gln Ile Lys Leu 
            20                  25                  30          


Pro Thr Val His Ile Gly Pro Thr Ala Phe Leu Gly Leu Gly Val Val 
        35                  40                  45              


Asp Asn Asn Gly Asn Gly Ala Arg Val Gln Arg Val Val Gly Ser Ala 
    50                  55                  60                  


Pro Ala Ala Ser Leu Gly Ile Ser Thr Gly Asp Val Ile Thr Ala Val 
65                  70                  75                  80  


Asp Gly Ala Pro Ile Asn Ser Ala Thr Ala Met Ala Asp Ala Leu Asn 
                85                  90                  95      


Gly His His Pro Gly Asp Val Ile Ser Val Thr Trp Gln Thr Lys Ser 
            100                 105                 110         


Gly Gly Thr Arg Thr Gly Asn Val Thr Leu Ala Glu Gly Pro Pro Ala 
        115                 120                 125             


<210> 46
<211> 128
<212> PRT
<213> Mycobacterium tuberculosis

<400> 46
Thr Ala Ala Ser Asp Asn Phe Gln Leu Ser Gln Gly Gly Gln Gly Phe 
1               5                   10                  15      


Ala Ile Pro Ile Gly Gln Ala Met Ala Ile Ala Gly Gln Ile Arg Ser 
            20                  25                  30          


Gly Gly Gly Ser Pro Thr Val His Ile Gly Pro Thr Ala Phe Leu Gly 
        35                  40                  45              


Leu Gly Val Val Asp Asn Asn Gly Asn Gly Ala Arg Val Gln Arg Val 
    50                  55                  60                  


Val Gly Ser Ala Pro Ala Ala Ser Leu Gly Ile Ser Thr Gly Asp Val 
65                  70                  75                  80  


Ile Thr Ala Val Asp Gly Ala Pro Ile Asn Ser Ala Thr Ala Met Ala 
                85                  90                  95      


Asp Ala Leu Asn Gly His His Pro Gly Asp Val Ile Ser Val Thr Trp 
            100                 105                 110         


Gln Thr Lys Ser Gly Gly Thr Arg Thr Gly Asn Val Thr Leu Ala Glu 
        115                 120                 125             


<210> 47
<211> 355
<212> PRT
<213> Mycobacterium tuberculosis

<400> 47
Met Ser Asn Ser Arg Arg Arg Ser Leu Arg Trp Ser Trp Leu Leu Ser 
1               5                   10                  15      


Val Leu Ala Ala Val Gly Leu Gly Leu Ala Thr Ala Pro Ala Gln Ala 
            20                  25                  30          


Ala Pro Pro Ala Leu Ser Gln Asp Arg Phe Ala Asp Phe Pro Ala Leu 
        35                  40                  45              


Pro Leu Asp Pro Ser Ala Met Val Ala Gln Val Gly Pro Gln Val Val 
    50                  55                  60                  


Asn Ile Asn Thr Lys Leu Gly Tyr Asn Asn Ala Val Gly Ala Gly Thr 
65                  70                  75                  80  


Gly Ile Val Ile Asp Pro Asn Gly Val Val Leu Thr Asn Asn His Val 
                85                  90                  95      


Ile Ala Gly Ala Thr Asp Ile Asn Ala Phe Ser Val Gly Ser Gly Gln 
            100                 105                 110         


Thr Tyr Gly Val Asp Val Val Gly Tyr Asp Arg Thr Gln Asp Val Ala 
        115                 120                 125             


Val Leu Gln Leu Arg Gly Ala Gly Gly Leu Pro Ser Ala Ala Ile Gly 
    130                 135                 140                 


Gly Gly Val Ala Val Gly Glu Pro Val Val Ala Met Gly Asn Ser Gly 
145                 150                 155                 160 


Gly Gln Gly Gly Thr Pro Arg Ala Val Pro Gly Arg Val Val Ala Leu 
                165                 170                 175     


Gly Gln Thr Val Gln Ala Ser Asp Ser Leu Thr Gly Ala Glu Glu Thr 
            180                 185                 190         


Leu Asn Gly Leu Ile Gln Phe Asp Ala Ala Ile Gln Pro Gly Asp Ser 
        195                 200                 205             


Gly Gly Pro Val Val Asn Gly Leu Gly Gln Val Val Gly Met Asn Thr 
    210                 215                 220                 


Ala Ala Ser Asp Asn Phe Gln Leu Ser Gln Gly Gly Gln Gly Phe Ala 
225                 230                 235                 240 


Ile Pro Ile Gly Gln Ala Met Ala Ile Ala Gly Gln Ile Arg Ser Gly 
                245                 250                 255     


Gly Gly Ser Pro Thr Val His Ile Gly Pro Thr Ala Phe Leu Gly Leu 
            260                 265                 270         


Gly Val Val Asp Asn Asn Gly Asn Gly Ala Arg Val Gln Arg Val Val 
        275                 280                 285             


Gly Ser Ala Pro Ala Ala Ser Leu Gly Ile Ser Thr Gly Asp Val Ile 
    290                 295                 300                 


Thr Ala Val Asp Gly Ala Pro Ile Asn Ser Ala Thr Ala Met Ala Asp 
305                 310                 315                 320 


Ala Leu Asn Gly His His Pro Gly Asp Val Ile Ser Val Thr Trp Gln 
                325                 330                 335     


Thr Lys Ser Gly Gly Thr Arg Thr Gly Asn Val Thr Leu Ala Glu Gly 
            340                 345                 350         


Pro Pro Ala 
        355 


<210> 48
<211> 364
<212> PRT
<213> Haemophilus influenzae

<400> 48
Met Lys Leu Lys Thr Leu Ala Leu Ser Leu Leu Ala Ala Gly Val Leu 
1               5                   10                  15      


Ala Gly Cys Ser Ser His Ser Ser Asn Met Ala Asn Thr Gln Met Lys 
            20                  25                  30          


Ser Asp Lys Ile Ile Ile Ala His Arg Gly Ala Ser Gly Tyr Leu Pro 
        35                  40                  45              


Glu His Thr Leu Glu Ser Lys Ala Leu Ala Phe Ala Gln Gln Ala Asp 
    50                  55                  60                  


Tyr Leu Glu Gln Asp Leu Ala Met Thr Lys Asp Gly Arg Leu Val Val 
65                  70                  75                  80  


Ile His Asp His Phe Leu Asp Gly Leu Thr Asp Val Ala Lys Lys Phe 
                85                  90                  95      


Pro His Arg His Arg Lys Asp Gly Arg Tyr Tyr Val Ile Asp Phe Thr 
            100                 105                 110         


Leu Lys Glu Ile Gln Ser Leu Glu Met Thr Glu Asn Phe Glu Thr Lys 
        115                 120                 125             


Asp Gly Lys Gln Ala Gln Val Tyr Pro Asn Arg Phe Pro Leu Trp Lys 
    130                 135                 140                 


Ser His Phe Arg Ile His Thr Phe Glu Asp Glu Ile Glu Phe Ile Gln 
145                 150                 155                 160 


Gly Leu Glu Lys Ser Thr Gly Lys Lys Val Gly Ile Tyr Pro Glu Ile 
                165                 170                 175     


Lys Ala Pro Trp Phe His His Gln Asn Gly Lys Asp Ile Ala Ala Glu 
            180                 185                 190         


Thr Leu Lys Val Leu Lys Lys Tyr Gly Tyr Asp Lys Lys Thr Asp Met 
        195                 200                 205             


Val Tyr Leu Gln Thr Phe Asp Phe Asn Glu Leu Lys Arg Ile Lys Thr 
    210                 215                 220                 


Glu Leu Leu Pro Gln Met Gly Met Asp Leu Lys Leu Val Gln Leu Ile 
225                 230                 235                 240 


Ala Tyr Thr Asp Trp Lys Glu Thr Gln Glu Lys Asp Pro Lys Gly Tyr 
                245                 250                 255     


Trp Val Asn Tyr Asn Tyr Asp Trp Met Phe Lys Pro Gly Ala Met Ala 
            260                 265                 270         


Glu Val Val Lys Tyr Ala Asp Gly Val Gly Pro Gly Trp Tyr Met Leu 
        275                 280                 285             


Val Asn Lys Glu Glu Ser Lys Pro Asp Asn Ile Val Tyr Thr Pro Leu 
    290                 295                 300                 


Val Lys Glu Leu Ala Gln Tyr Asn Val Glu Val His Pro Tyr Thr Val 
305                 310                 315                 320 


Arg Lys Asp Ala Leu Pro Ala Phe Phe Thr Asp Val Asn Gln Met Tyr 
                325                 330                 335     


Asp Val Leu Leu Asn Lys Ser Gly Ala Thr Gly Val Phe Thr Asp Phe 
            340                 345                 350         


Pro Asp Thr Gly Val Glu Phe Leu Lys Gly Ile Lys 
        355                 360                 


<210> 49
<211> 313
<212> PRT
<213> Streptococcus pneumonae

<400> 49
Met Glu Ile Asn Val Ser Lys Leu Arg Thr Asp Leu Pro Gln Val Gly 
1               5                   10                  15      


Val Gln Pro Tyr Arg Gln Val His Ala His Ser Thr Gly Asn Pro His 
            20                  25                  30          


Ser Thr Val Gln Asn Glu Ala Asp Tyr His Trp Arg Lys Asp Pro Glu 
        35                  40                  45              


Leu Gly Phe Phe Ser His Ile Val Gly Asn Gly Cys Ile Met Gln Val 
    50                  55                  60                  


Gly Pro Val Asp Asn Gly Ala Trp Asp Val Gly Gly Gly Trp Asn Ala 
65                  70                  75                  80  


Glu Thr Tyr Ala Ala Val Glu Leu Ile Glu Ser His Ser Thr Lys Glu 
                85                  90                  95      


Glu Phe Met Thr Asp Tyr Arg Leu Tyr Ile Glu Leu Leu Arg Asn Leu 
            100                 105                 110         


Ala Asp Glu Ala Gly Leu Pro Lys Thr Leu Asp Thr Gly Ser Leu Ala 
        115                 120                 125             


Gly Ile Lys Thr His Glu Tyr Cys Thr Asn Asn Gln Pro Asn Asn His 
    130                 135                 140                 


Ser Asp His Val Asp Pro Tyr Pro Tyr Leu Ala Lys Trp Gly Ile Ser 
145                 150                 155                 160 


Arg Glu Gln Phe Lys His Asp Ile Glu Asn Gly Leu Thr Ile Glu Thr 
                165                 170                 175     


Gly Trp Gln Lys Asn Asp Thr Gly Tyr Trp Tyr Val His Ser Asp Gly 
            180                 185                 190         


Ser Tyr Pro Lys Asp Lys Phe Glu Lys Ile Asn Gly Thr Trp Tyr Tyr 
        195                 200                 205             


Phe Asp Ser Ser Gly Tyr Met Leu Ala Asp Arg Trp Arg Lys His Thr 
    210                 215                 220                 


Asp Gly Asn Trp Tyr Trp Phe Asp Asn Ser Gly Glu Met Ala Thr Gly 
225                 230                 235                 240 


Trp Lys Lys Ile Ala Asp Lys Trp Tyr Tyr Phe Asn Glu Glu Gly Ala 
                245                 250                 255     


Met Lys Thr Gly Trp Val Lys Tyr Lys Asp Thr Trp Tyr Tyr Leu Asp 
            260                 265                 270         


Ala Lys Glu Gly Ala Met Val Ser Asn Ala Phe Ile Gln Ser Ala Asp 
        275                 280                 285             


Gly Thr Gly Trp Tyr Tyr Leu Lys Pro Asp Gly Thr Leu Ala Asp Arg 
    290                 295                 300                 


Pro Glu Phe Arg Met Ser Gln Met Ala 
305                 310             


<210> 50
<211> 166
<212> PRT
<213> Homo sapiens

<400> 50
Met Lys Tyr Thr Ser Tyr Ile Leu Ala Phe Gln Leu Cys Ile Val Leu 
1               5                   10                  15      


Gly Ser Leu Gly Cys Tyr Cys Gln Asp Pro Tyr Val Lys Glu Ala Glu 
            20                  25                  30          


Asn Leu Lys Lys Tyr Phe Asn Ala Gly His Ser Asp Val Ala Asp Asn 
        35                  40                  45              


Gly Thr Leu Phe Leu Gly Ile Leu Lys Asn Trp Lys Glu Glu Ser Asp 
    50                  55                  60                  


Arg Lys Ile Met Gln Ser Gln Ile Val Ser Phe Tyr Phe Lys Leu Phe 
65                  70                  75                  80  


Lys Asn Phe Lys Asp Asp Gln Ser Ile Gln Lys Ser Val Glu Thr Ile 
                85                  90                  95      


Lys Glu Asp Met Asn Val Lys Phe Phe Asn Ser Asn Lys Lys Lys Arg 
            100                 105                 110         


Asp Asp Phe Glu Lys Leu Thr Asn Tyr Ser Val Thr Asp Leu Asn Val 
        115                 120                 125             


Gln Arg Lys Ala Ile His Glu Leu Ile Gln Val Met Ala Glu Leu Ser 
    130                 135                 140                 


Pro Ala Ala Lys Thr Gly Lys Arg Lys Arg Ser Gln Met Leu Phe Arg 
145                 150                 155                 160 


Gly Arg Arg Ala Ser Gln 
                165     


<210> 51
<211> 233
<212> PRT
<213> Homo sapiens

<400> 51
Met Ser Thr Glu Ser Met Ile Arg Asp Val Glu Leu Ala Glu Glu Ala 
1               5                   10                  15      


Leu Pro Lys Lys Thr Gly Gly Pro Gln Gly Ser Arg Arg Cys Leu Phe 
            20                  25                  30          


Leu Ser Leu Phe Ser Phe Leu Ile Val Ala Gly Ala Thr Thr Leu Phe 
        35                  40                  45              


Cys Leu Leu His Phe Gly Val Ile Gly Pro Gln Arg Glu Glu Phe Pro 
    50                  55                  60                  


Arg Asp Leu Ser Leu Ile Ser Pro Leu Ala Gln Ala Val Arg Ser Ser 
65                  70                  75                  80  


Ser Arg Thr Pro Ser Asp Lys Pro Val Ala His Val Val Ala Asn Pro 
                85                  90                  95      


Gln Ala Glu Gly Gln Leu Gln Trp Leu Asn Arg Arg Ala Asn Ala Leu 
            100                 105                 110         


Leu Ala Asn Gly Val Glu Leu Arg Asp Asn Gln Leu Val Val Pro Ser 
        115                 120                 125             


Glu Gly Leu Tyr Leu Ile Tyr Ser Gln Val Leu Phe Lys Gly Gln Gly 
    130                 135                 140                 


Cys Pro Ser Thr His Val Leu Leu Thr His Thr Ile Ser Arg Ile Ala 
145                 150                 155                 160 


Val Ser Tyr Gln Thr Lys Val Asn Leu Leu Ser Ala Ile Lys Ser Pro 
                165                 170                 175     


Cys Gln Arg Glu Thr Pro Glu Gly Ala Glu Ala Lys Pro Trp Tyr Glu 
            180                 185                 190         


Pro Ile Tyr Leu Gly Gly Val Phe Gln Leu Glu Lys Gly Asp Arg Leu 
        195                 200                 205             


Ser Ala Glu Ile Asn Arg Pro Asp Tyr Leu Asp Phe Ala Glu Ser Gly 
    210                 215                 220                 


Gln Val Tyr Phe Gly Ile Ile Ala Leu 
225                 230             


<210> 52
<211> 153
<212> PRT
<213> Homo sapiens

<400> 52
Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu 
            20                  25                  30          


Gln Leu Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile 
        35                  40                  45              


Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe 
    50                  55                  60                  


Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu 
65                  70                  75                  80  


Glu Glu Leu Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys 
                85                  90                  95      


Asn Phe His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile 
            100                 105                 110         


Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala 
        115                 120                 125             


Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe 
    130                 135                 140                 


Cys Gln Ser Ile Ile Ser Thr Leu Thr 
145                 150             


<210> 53
<211> 99
<212> PRT
<213> Homo sapiens

<400> 53
Met Thr Ser Lys Leu Ala Val Ala Leu Leu Ala Ala Phe Leu Ile Ser 
1               5                   10                  15      


Ala Ala Leu Cys Glu Gly Ala Val Leu Pro Arg Ser Ala Lys Glu Leu 
            20                  25                  30          


Arg Cys Gln Cys Ile Lys Thr Tyr Ser Lys Pro Phe His Pro Lys Phe 
        35                  40                  45              


Ile Lys Glu Leu Arg Val Ile Glu Ser Gly Pro His Cys Ala Asn Thr 
    50                  55                  60                  


Glu Ile Ile Val Lys Leu Ser Asp Gly Arg Glu Leu Cys Leu Asp Pro 
65                  70                  75                  80  


Lys Glu Asn Trp Val Gln Arg Val Val Glu Lys Phe Leu Lys Arg Ala 
                85                  90                  95      


Glu Asn Ser 
            


<210> 54
<211> 662
<212> PRT
<213> Homo sapiens

<400> 54
Met Glu Pro Leu Val Thr Trp Val Val Pro Leu Leu Phe Leu Phe Leu 
1               5                   10                  15      


Leu Ser Arg Gln Gly Ala Ala Cys Arg Thr Ser Glu Cys Cys Phe Gln 
            20                  25                  30          


Asp Pro Pro Tyr Pro Asp Ala Asp Ser Gly Ser Ala Ser Gly Pro Arg 
        35                  40                  45              


Asp Leu Arg Cys Tyr Arg Ile Ser Ser Asp Arg Tyr Glu Cys Ser Trp 
    50                  55                  60                  


Gln Tyr Glu Gly Pro Thr Ala Gly Val Ser His Phe Leu Arg Cys Cys 
65                  70                  75                  80  


Leu Ser Ser Gly Arg Cys Cys Tyr Phe Ala Ala Gly Ser Ala Thr Arg 
                85                  90                  95      


Leu Gln Phe Ser Asp Gln Ala Gly Val Ser Val Leu Tyr Thr Val Thr 
            100                 105                 110         


Leu Trp Val Glu Ser Trp Ala Arg Asn Gln Thr Glu Lys Ser Pro Glu 
        115                 120                 125             


Val Thr Leu Gln Leu Tyr Asn Ser Val Lys Tyr Glu Pro Pro Leu Gly 
    130                 135                 140                 


Asp Ile Lys Val Ser Lys Leu Ala Gly Gln Leu Arg Met Glu Trp Glu 
145                 150                 155                 160 


Thr Pro Asp Asn Gln Val Gly Ala Glu Val Gln Phe Arg His Arg Thr 
                165                 170                 175     


Pro Ser Ser Pro Trp Lys Leu Gly Asp Cys Gly Pro Gln Asp Asp Asp 
            180                 185                 190         


Thr Glu Ser Cys Leu Cys Pro Leu Glu Met Asn Val Ala Gln Glu Phe 
        195                 200                 205             


Gln Leu Arg Arg Arg Gln Leu Gly Ser Gln Gly Ser Ser Trp Ser Lys 
    210                 215                 220                 


Trp Ser Ser Pro Val Cys Val Pro Pro Glu Asn Pro Pro Gln Pro Gln 
225                 230                 235                 240 


Val Arg Phe Ser Val Glu Gln Leu Gly Gln Asp Gly Arg Arg Arg Leu 
                245                 250                 255     


Thr Leu Lys Glu Gln Pro Thr Gln Leu Glu Leu Pro Glu Gly Cys Gln 
            260                 265                 270         


Gly Leu Ala Pro Gly Thr Glu Val Thr Tyr Arg Leu Gln Leu His Met 
        275                 280                 285             


Leu Ser Cys Pro Cys Lys Ala Lys Ala Thr Arg Thr Leu His Leu Gly 
    290                 295                 300                 


Lys Met Pro Tyr Leu Ser Gly Ala Ala Tyr Asn Val Ala Val Ile Ser 
305                 310                 315                 320 


Ser Asn Gln Phe Gly Pro Gly Leu Asn Gln Thr Trp His Ile Pro Ala 
                325                 330                 335     


Asp Thr His Thr Glu Pro Val Ala Leu Asn Ile Ser Val Gly Thr Asn 
            340                 345                 350         


Gly Thr Thr Met Tyr Trp Pro Ala Arg Ala Gln Ser Met Thr Tyr Cys 
        355                 360                 365             


Ile Glu Trp Gln Pro Val Gly Gln Asp Gly Gly Leu Ala Thr Cys Ser 
    370                 375                 380                 


Leu Thr Ala Pro Gln Asp Pro Asp Pro Ala Gly Met Ala Thr Tyr Ser 
385                 390                 395                 400 


Trp Ser Arg Glu Ser Gly Ala Met Gly Gln Glu Lys Cys Tyr Tyr Ile 
                405                 410                 415     


Thr Ile Phe Ala Ser Ala His Pro Glu Lys Leu Thr Leu Trp Ser Thr 
            420                 425                 430         


Val Leu Ser Thr Tyr His Phe Gly Gly Asn Ala Ser Ala Ala Gly Thr 
        435                 440                 445             


Pro His His Val Ser Val Lys Asn His Ser Leu Asp Ser Val Ser Val 
    450                 455                 460                 


Asp Trp Ala Pro Ser Leu Leu Ser Thr Cys Pro Gly Val Leu Lys Glu 
465                 470                 475                 480 


Tyr Val Val Arg Cys Arg Asp Glu Asp Ser Lys Gln Val Ser Glu His 
                485                 490                 495     


Pro Val Gln Pro Thr Glu Thr Gln Val Thr Leu Ser Gly Leu Arg Ala 
            500                 505                 510         


Gly Val Ala Tyr Thr Val Gln Val Arg Ala Asp Thr Ala Trp Leu Arg 
        515                 520                 525             


Gly Val Trp Ser Gln Pro Gln Arg Phe Ser Ile Glu Val Gln Val Ser 
    530                 535                 540                 


Asp Trp Leu Ile Phe Phe Ala Ser Leu Gly Ser Phe Leu Ser Ile Leu 
545                 550                 555                 560 


Leu Val Gly Val Leu Gly Tyr Leu Gly Leu Asn Arg Ala Ala Arg His 
                565                 570                 575     


Leu Cys Pro Pro Leu Pro Thr Pro Cys Ala Ser Ser Ala Ile Glu Phe 
            580                 585                 590         


Pro Gly Gly Lys Glu Thr Trp Gln Trp Ile Asn Pro Val Asp Phe Gln 
        595                 600                 605             


Glu Glu Ala Ser Leu Gln Glu Ala Leu Val Val Glu Met Ser Trp Asp 
    610                 615                 620                 


Lys Gly Glu Arg Thr Glu Pro Leu Glu Lys Thr Glu Leu Pro Glu Gly 
625                 630                 635                 640 


Ala Pro Glu Leu Ala Leu Asp Thr Glu Leu Ser Leu Glu Asp Gly Asp 
                645                 650                 655     


Arg Cys Lys Ala Lys Met 
            660         


<210> 55
<211> 193
<212> PRT
<213> Homo sapiens

<400> 55
Met Ala Ala Glu Pro Val Glu Asp Asn Cys Ile Asn Phe Val Ala Met 
1               5                   10                  15      


Lys Phe Ile Asp Asn Thr Leu Tyr Phe Ile Ala Glu Asp Asp Glu Asn 
            20                  25                  30          


Leu Glu Ser Asp Tyr Phe Gly Lys Leu Glu Ser Lys Leu Ser Val Ile 
        35                  40                  45              


Arg Asn Leu Asn Asp Gln Val Leu Phe Ile Asp Gln Gly Asn Arg Pro 
    50                  55                  60                  


Leu Phe Glu Asp Met Thr Asp Ser Asp Cys Arg Asp Asn Ala Pro Arg 
65                  70                  75                  80  


Thr Ile Phe Ile Ile Ser Met Tyr Lys Asp Ser Gln Pro Arg Gly Met 
                85                  90                  95      


Ala Val Thr Ile Ser Val Lys Cys Glu Lys Ile Ser Thr Leu Ser Cys 
            100                 105                 110         


Glu Asn Lys Ile Ile Ser Phe Lys Glu Met Asn Pro Pro Asp Asn Ile 
        115                 120                 125             


Lys Asp Thr Lys Ser Asp Ile Ile Phe Phe Gln Arg Ser Val Pro Gly 
    130                 135                 140                 


His Asp Asn Lys Met Gln Phe Glu Ser Ser Ser Tyr Glu Gly Tyr Phe 
145                 150                 155                 160 


Leu Ala Cys Glu Lys Glu Arg Asp Leu Phe Lys Leu Ile Leu Lys Lys 
                165                 170                 175     


Glu Asp Glu Leu Gly Asp Arg Ser Ile Met Phe Thr Val Gln Asn Glu 
            180                 185                 190         


Asp 
    


<210> 56
<211> 177
<212> PRT
<213> Homo sapiens

<400> 56
Met Phe His Val Ser Phe Arg Tyr Ile Phe Gly Leu Pro Pro Leu Ile 
1               5                   10                  15      


Leu Val Leu Leu Pro Val Ala Ser Ser Asp Cys Asp Ile Glu Gly Lys 
            20                  25                  30          


Asp Gly Lys Gln Tyr Glu Ser Val Leu Met Val Ser Ile Asp Gln Leu 
        35                  40                  45              


Leu Asp Ser Met Lys Glu Ile Gly Ser Asn Cys Leu Asn Asn Glu Phe 
    50                  55                  60                  


Asn Phe Phe Lys Arg His Ile Cys Asp Ala Asn Lys Glu Gly Met Phe 
65                  70                  75                  80  


Leu Phe Arg Ala Ala Arg Lys Leu Arg Gln Phe Leu Lys Met Asn Ser 
                85                  90                  95      


Thr Gly Asp Phe Asp Leu His Leu Leu Lys Val Ser Glu Gly Thr Thr 
            100                 105                 110         


Ile Leu Leu Asn Cys Thr Gly Gln Val Lys Gly Arg Lys Pro Ala Ala 
        115                 120                 125             


Leu Gly Glu Ala Gln Pro Thr Lys Ser Leu Glu Glu Asn Lys Ser Leu 
    130                 135                 140                 


Lys Glu Gln Lys Lys Leu Asn Asp Leu Cys Phe Leu Lys Arg Leu Leu 
145                 150                 155                 160 


Gln Glu Ile Lys Thr Cys Trp Asn Lys Ile Leu Met Gly Thr Lys Glu 
                165                 170                 175     


His 
    


<210> 57
<211> 152
<212> PRT
<213> Homo sapiens

<400> 57
Met Ser Arg Leu Pro Val Leu Leu Leu Leu Gln Leu Leu Val Arg Pro 
1               5                   10                  15      


Gly Leu Gln Ala Pro Met Thr Gln Thr Thr Ser Leu Lys Thr Ser Trp 
            20                  25                  30          


Val Asn Cys Ser Asn Met Ile Asp Glu Ile Ile Thr His Leu Lys Gln 
        35                  40                  45              


Pro Pro Leu Pro Leu Leu Asp Phe Asn Asn Leu Asn Gly Glu Asp Gln 
    50                  55                  60                  


Asp Ile Leu Met Glu Asn Asn Leu Arg Arg Pro Asn Leu Glu Ala Phe 
65                  70                  75                  80  


Asn Arg Ala Val Lys Ser Leu Gln Asn Ala Ser Ala Ile Glu Ser Ile 
                85                  90                  95      


Leu Lys Asn Leu Leu Pro Cys Leu Pro Leu Ala Thr Ala Ala Pro Thr 
            100                 105                 110         


Arg His Pro Ile His Ile Lys Asp Gly Asp Trp Asn Glu Phe Arg Arg 
        115                 120                 125             


Lys Leu Thr Phe Tyr Leu Lys Thr Leu Glu Asn Ala Gln Ala Gln Gln 
    130                 135                 140                 


Thr Thr Leu Ser Leu Ala Ile Phe 
145                 150         


<210> 58
<211> 153
<212> PRT
<213> Homo sapiens

<400> 58
Met Gly Leu Thr Ser Gln Leu Leu Pro Pro Leu Phe Phe Leu Leu Ala 
1               5                   10                  15      


Cys Ala Gly Asn Phe Val His Gly His Lys Cys Asp Ile Thr Leu Gln 
            20                  25                  30          


Glu Ile Ile Lys Thr Leu Asn Ser Leu Thr Glu Gln Lys Thr Leu Cys 
        35                  40                  45              


Thr Glu Leu Thr Val Thr Asp Ile Phe Ala Ala Ser Lys Asn Thr Thr 
    50                  55                  60                  


Glu Lys Glu Thr Phe Cys Arg Ala Ala Thr Val Leu Arg Gln Phe Tyr 
65                  70                  75                  80  


Ser His His Glu Lys Asp Thr Arg Cys Leu Gly Ala Thr Ala Gln Gln 
                85                  90                  95      


Phe His Arg His Lys Gln Leu Ile Arg Phe Leu Lys Arg Leu Asp Arg 
            100                 105                 110         


Asn Leu Trp Gly Leu Ala Gly Leu Asn Ser Cys Pro Val Lys Glu Ala 
        115                 120                 125             


Asn Gln Ser Thr Leu Glu Asn Phe Leu Glu Arg Leu Lys Thr Ile Met 
    130                 135                 140                 


Arg Glu Lys Tyr Ser Lys Cys Ser Ser 
145                 150             


<210> 59
<211> 134
<212> PRT
<213> Homo sapiens

<400> 59
Met Arg Met Leu Leu His Leu Ser Leu Leu Ala Leu Gly Ala Ala Tyr 
1               5                   10                  15      


Val Tyr Ala Ile Pro Thr Glu Ile Pro Thr Ser Ala Leu Val Lys Glu 
            20                  25                  30          


Thr Leu Ala Leu Leu Ser Thr His Arg Thr Leu Leu Ile Ala Asn Glu 
        35                  40                  45              


Thr Leu Arg Ile Pro Val Pro Val His Lys Asn His Gln Leu Cys Thr 
    50                  55                  60                  


Glu Glu Ile Phe Gln Gly Ile Gly Thr Leu Glu Ser Gln Thr Val Gln 
65                  70                  75                  80  


Gly Gly Thr Val Glu Arg Leu Phe Lys Asn Leu Ser Leu Ile Lys Lys 
                85                  90                  95      


Tyr Ile Asp Gly Gln Lys Lys Lys Cys Gly Glu Glu Arg Arg Arg Val 
            100                 105                 110         


Asn Gln Phe Leu Asp Tyr Leu Gln Glu Phe Leu Gly Val Met Asn Thr 
        115                 120                 125             


Glu Trp Ile Ile Glu Ser 
    130                 


<210> 60
<211> 212
<212> PRT
<213> Homo sapiens

<400> 60
Met Asn Ser Phe Ser Thr Ser Ala Phe Gly Pro Val Ala Phe Ser Leu 
1               5                   10                  15      


Gly Leu Leu Leu Val Leu Pro Ala Ala Phe Pro Ala Pro Val Pro Pro 
            20                  25                  30          


Gly Glu Asp Ser Lys Asp Val Ala Ala Pro His Arg Gln Pro Leu Thr 
        35                  40                  45              


Ser Ser Glu Arg Ile Asp Lys Gln Ile Arg Tyr Ile Leu Asp Gly Ile 
    50                  55                  60                  


Ser Ala Leu Arg Lys Glu Thr Cys Asn Lys Ser Asn Met Cys Glu Ser 
65                  70                  75                  80  


Ser Lys Glu Ala Leu Ala Glu Asn Asn Leu Asn Leu Pro Lys Met Ala 
                85                  90                  95      


Glu Lys Asp Gly Cys Phe Gln Ser Gly Phe Asn Glu Glu Thr Cys Leu 
            100                 105                 110         


Val Lys Ile Ile Thr Gly Leu Leu Glu Phe Glu Val Tyr Leu Glu Tyr 
        115                 120                 125             


Leu Gln Asn Arg Phe Glu Ser Ser Glu Glu Gln Ala Arg Ala Val Gln 
    130                 135                 140                 


Met Ser Thr Lys Val Leu Ile Gln Phe Leu Gln Lys Lys Ala Lys Asn 
145                 150                 155                 160 


Leu Asp Ala Ile Thr Thr Pro Asp Pro Thr Thr Asn Ala Ser Leu Leu 
                165                 170                 175     


Thr Lys Leu Gln Ala Gln Asn Gln Trp Leu Gln Asp Met Thr Thr His 
            180                 185                 190         


Leu Ile Leu Arg Ser Phe Lys Glu Phe Leu Gln Ser Ser Leu Arg Ala 
        195                 200                 205             


Leu Arg Gln Met 
    210         


<210> 61
<211> 140
<212> PRT
<213> Homo sapiens

<400> 61
Met Val Leu Thr Ser Ala Leu Leu Leu Cys Ser Val Ala Gly Gln Gly 
1               5                   10                  15      


Cys Pro Thr Leu Ala Gly Ile Leu Asp Ile Asn Phe Leu Ile Asn Lys 
            20                  25                  30          


Met Gln Glu Asp Pro Ala Ser Lys Cys His Cys Ser Ala Asn Val Thr 
        35                  40                  45              


Ser Cys Leu Cys Leu Gly Ile Pro Ser Asp Asn Cys Thr Arg Pro Cys 
    50                  55                  60                  


Phe Ser Glu Arg Leu Ser Gln Met Thr Asn Thr Thr Met Gln Thr Arg 
65                  70                  75                  80  


Tyr Pro Leu Ile Phe Ser Arg Val Lys Lys Ser Val Glu Val Leu Lys 
                85                  90                  95      


Asn Asn Lys Cys Pro Tyr Phe Ser Cys Glu Gln Pro Cys Asn Gln Thr 
            100                 105                 110         


Thr Ala Gly Asn Ala Leu Thr Phe Leu Lys Ser Leu Leu Glu Ile Phe 
        115                 120                 125             


Gln Lys Glu Lys Met Arg Gly Met Arg Gly Lys Ile 
    130                 135                 140 


<210> 62
<211> 178
<212> PRT
<213> Homo sapiens

<400> 62
Met His Ser Ser Ala Leu Leu Cys Cys Leu Val Leu Leu Thr Gly Val 
1               5                   10                  15      


Arg Ala Ser Pro Gly Gln Gly Thr Gln Ser Glu Asn Ser Cys Thr His 
            20                  25                  30          


Phe Pro Gly Asn Leu Pro Asn Met Leu Arg Asp Leu Arg Asp Ala Phe 
        35                  40                  45              


Ser Arg Val Lys Thr Phe Phe Gln Met Lys Asp Gln Leu Asp Asn Leu 
    50                  55                  60                  


Leu Leu Lys Glu Ser Leu Leu Glu Asp Phe Lys Gly Tyr Leu Gly Cys 
65                  70                  75                  80  


Gln Ala Leu Ser Glu Met Ile Gln Phe Tyr Leu Glu Glu Val Met Pro 
                85                  90                  95      


Gln Ala Glu Asn Gln Asp Pro Asp Ile Lys Ala His Val Asn Ser Leu 
            100                 105                 110         


Gly Glu Asn Leu Lys Thr Leu Arg Leu Arg Leu Arg Arg Cys His Arg 
        115                 120                 125             


Phe Leu Pro Cys Glu Asn Lys Ser Lys Ala Val Glu Gln Val Lys Asn 
    130                 135                 140                 


Ala Phe Asn Lys Leu Gln Glu Lys Gly Ile Tyr Lys Ala Met Ser Glu 
145                 150                 155                 160 


Phe Asp Ile Phe Ile Asn Tyr Ile Glu Ala Tyr Met Thr Met Lys Ile 
                165                 170                 175     


Arg Asn 
        


<210> 63
<211> 145
<212> PRT
<213> Homo sapiens

<400> 63
Met Ala Leu Leu Leu Thr Thr Val Ile Ala Leu Thr Cys Leu Gly Gly 
1               5                   10                  15      


Phe Ala Ser Pro Gly Pro Val Pro Pro Ser Thr Ala Leu Arg Glu Leu 
            20                  25                  30          


Ile Glu Glu Leu Val Asn Ile Thr Gln Asn Gln Lys Ala Pro Leu Cys 
        35                  40                  45              


Asn Gly Ser Met Val Trp Ser Ile Asn Leu Thr Ala Gly Met Tyr Cys 
    50                  55                  60                  


Ala Ala Leu Glu Ser Leu Ile Asn Val Ser Gly Cys Ser Ala Ile Glu 
65                  70                  75                  80  


Lys Thr Gln Arg Met Leu Ser Gly Phe Cys Pro His Lys Val Ser Ala 
                85                  90                  95      


Gly Gln Phe Ser Ser Leu His Val Arg Asp Thr Lys Ile Glu Val Ala 
            100                 105                 110         


Gln Phe Val Lys Asp Leu Leu Leu His Leu Lys Lys Leu Phe Arg Glu 
        115                 120                 125             


Gly Gln Phe Asn Arg Asn Phe Glu Ser Ile Ile Ile Cys Arg Asp Arg 
    130                 135                 140                 


Thr 
145 


<210> 64
<211> 136
<212> PRT
<213> Homo sapiens

<400> 64
Met Asp Phe Gln Val Gln Ile Phe Ser Phe Leu Leu Ile Ser Ala Ser 
1               5                   10                  15      


Val Ile Met Ser Arg Ala Asn Trp Val Asn Val Ile Ser Asp Leu Lys 
            20                  25                  30          


Lys Ile Glu Asp Leu Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr 
        35                  40                  45              


Thr Glu Ser Asp Val His Pro Ser Cys Lys Val Thr Ala Met Lys Cys 
    50                  55                  60                  


Phe Leu Leu Glu Leu Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser 
65                  70                  75                  80  


Ile His Asp Thr Val Glu Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu 
                85                  90                  95      


Ser Ser Asn Gly Asn Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu 
            100                 105                 110         


Leu Glu Glu Lys Asn Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile 
        115                 120                 125             


Val Gln Met Phe Ile Asn Thr Ser 
    130                 135     


<210> 65
<211> 656
<212> PRT
<213> Homo sapiens

<400> 65
Met Glu Gly Asp Gly Ser Asp Pro Glu Pro Pro Asp Ala Gly Glu Asp 
1               5                   10                  15      


Ser Lys Ser Glu Asn Gly Glu Asn Ala Pro Ile Tyr Cys Ile Cys Arg 
            20                  25                  30          


Lys Pro Asp Ile Asn Cys Phe Met Ile Gly Cys Asp Asn Cys Asn Glu 
        35                  40                  45              


Trp Phe His Gly Asp Cys Ile Arg Ile Thr Glu Lys Met Ala Lys Ala 
    50                  55                  60                  


Ile Arg Glu Trp Tyr Cys Arg Glu Cys Arg Glu Lys Asp Pro Lys Leu 
65                  70                  75                  80  


Glu Ile Arg Tyr Arg His Lys Lys Ser Arg Glu Arg Asp Gly Asn Glu 
                85                  90                  95      


Arg Asp Ser Ser Glu Pro Arg Asp Glu Gly Gly Gly Arg Lys Arg Pro 
            100                 105                 110         


Val Pro Asp Pro Asn Leu Gln Arg Arg Ala Gly Ser Gly Thr Gly Val 
        115                 120                 125             


Gly Ala Met Leu Ala Arg Gly Ser Ala Ser Pro His Lys Ser Ser Pro 
    130                 135                 140                 


Gln Pro Leu Val Ala Thr Pro Ser Gln His His Gln Gln Gln Gln Gln 
145                 150                 155                 160 


Gln Ile Lys Arg Ser Ala Arg Met Cys Gly Glu Cys Glu Ala Cys Arg 
                165                 170                 175     


Arg Thr Glu Asp Cys Gly His Cys Asp Phe Cys Arg Asp Met Lys Lys 
            180                 185                 190         


Phe Gly Gly Pro Asn Lys Ile Arg Gln Lys Cys Arg Leu Arg Gln Cys 
        195                 200                 205             


Gln Leu Arg Ala Arg Glu Ser Tyr Lys Tyr Phe Pro Ser Ser Leu Ser 
    210                 215                 220                 


Pro Val Thr Pro Ser Glu Ser Leu Pro Arg Pro Arg Arg Pro Leu Pro 
225                 230                 235                 240 


Thr Gln Gln Gln Pro Gln Pro Ser Gln Lys Leu Gly Arg Ile Arg Glu 
                245                 250                 255     


Asp Glu Gly Ala Val Ala Ser Ser Thr Val Lys Glu Pro Pro Glu Ala 
            260                 265                 270         


Thr Ala Thr Pro Glu Pro Leu Ser Asp Glu Asp Leu Pro Leu Asp Pro 
        275                 280                 285             


Asp Leu Tyr Gln Asp Phe Cys Ala Gly Ala Phe Asp Asp Asn Gly Leu 
    290                 295                 300                 


Pro Trp Met Ser Asp Thr Glu Glu Ser Pro Phe Leu Asp Pro Ala Leu 
305                 310                 315                 320 


Arg Lys Arg Ala Val Lys Val Lys His Val Lys Arg Arg Glu Lys Lys 
                325                 330                 335     


Ser Glu Lys Lys Lys Glu Glu Arg Tyr Lys Arg His Arg Gln Lys Gln 
            340                 345                 350         


Lys His Lys Asp Lys Trp Lys His Pro Glu Arg Ala Asp Ala Lys Asp 
        355                 360                 365             


Pro Ala Ser Leu Pro Gln Cys Leu Gly Pro Gly Cys Val Arg Pro Ala 
    370                 375                 380                 


Gln Pro Ser Ser Lys Tyr Cys Ser Asp Asp Cys Gly Met Lys Leu Ala 
385                 390                 395                 400 


Ala Asn Arg Ile Tyr Glu Ile Leu Pro Gln Arg Ile Gln Gln Trp Gln 
                405                 410                 415     


Gln Ser Pro Cys Ile Ala Glu Glu His Gly Lys Lys Leu Leu Glu Arg 
            420                 425                 430         


Ile Arg Arg Glu Gln Gln Ser Ala Arg Thr Arg Leu Gln Glu Met Glu 
        435                 440                 445             


Arg Arg Phe His Glu Leu Glu Ala Ile Ile Leu Arg Ala Lys Gln Gln 
    450                 455                 460                 


Ala Val Arg Glu Asp Glu Glu Ser Asn Glu Gly Asp Ser Asp Asp Thr 
465                 470                 475                 480 


Asp Leu Gln Ile Phe Cys Val Ser Cys Gly His Pro Ile Asn Pro Arg 
                485                 490                 495     


Val Ala Leu Arg His Met Glu Arg Cys Tyr Ala Lys Tyr Glu Ser Gln 
            500                 505                 510         


Thr Ser Phe Gly Ser Met Tyr Pro Thr Arg Ile Glu Gly Ala Thr Arg 
        515                 520                 525             


Leu Phe Cys Asp Val Tyr Asn Pro Gln Ser Lys Thr Tyr Cys Lys Arg 
    530                 535                 540                 


Leu Gln Val Leu Cys Pro Glu His Ser Arg Asp Pro Lys Val Pro Ala 
545                 550                 555                 560 


Asp Glu Val Cys Gly Cys Pro Leu Val Arg Asp Val Phe Glu Leu Thr 
                565                 570                 575     


Gly Asp Phe Cys Arg Leu Pro Lys Arg Gln Cys Asn Arg His Tyr Cys 
            580                 585                 590         


Trp Glu Lys Leu Arg Arg Ala Glu Val Asp Leu Glu Arg Val Arg Val 
        595                 600                 605             


Trp Tyr Lys Leu Asp Glu Leu Phe Glu Gln Glu Arg Asn Val Arg Thr 
    610                 615                 620                 


Ala Met Thr Asn Arg Ala Gly Leu Leu Ala Leu Met Leu His Gln Thr 
625                 630                 635                 640 


Ile Gln His Asp Pro Leu Thr Thr Asp Leu Arg Ser Ser Ala Asp Arg 
                645                 650                 655     


<210> 66
<211> 124
<212> PRT
<213> Vibrio cholerae

<400> 66
Met Ile Lys Leu Lys Phe Gly Val Phe Phe Thr Val Leu Leu Ser Ser 
1               5                   10                  15      


Ala Tyr Ala His Gly Thr Pro Gln Asn Ile Thr Asp Leu Cys Ala Glu 
            20                  25                  30          


Tyr His Asn Thr Gln Ile Tyr Thr Leu Asn Asp Lys Ile Phe Ser Tyr 
        35                  40                  45              


Thr Glu Ser Leu Ala Gly Lys Arg Glu Met Ala Ile Ile Thr Phe Lys 
    50                  55                  60                  


Asn Gly Ala Ile Phe Gln Val Glu Val Pro Gly Ser Gln His Ile Asp 
65                  70                  75                  80  


Ser Gln Lys Lys Ala Ile Glu Arg Met Lys Asp Thr Leu Arg Ile Ala 
                85                  90                  95      


Tyr Leu Thr Glu Ala Lys Val Glu Lys Leu Cys Val Trp Asn Asn Lys 
            100                 105                 110         


Thr Pro His Ala Ile Ala Ala Ile Ser Met Ala Asn 
        115                 120                 


<210> 67
<211> 258
<212> PRT
<213> Vibrio cholerae

<400> 67
Met Val Lys Ile Ile Phe Val Phe Phe Ile Phe Leu Ser Ser Phe Ser 
1               5                   10                  15      


Tyr Ala Asn Asp Asp Lys Leu Tyr Arg Ala Asp Ser Arg Pro Pro Asp 
            20                  25                  30          


Glu Ile Lys Gln Ser Gly Gly Leu Met Pro Arg Gly Gln Asn Glu Tyr 
        35                  40                  45              


Phe Asp Arg Gly Thr Gln Met Asn Ile Asn Leu Tyr Asp His Ala Arg 
    50                  55                  60                  


Gly Thr Gln Thr Gly Phe Val Arg His Asp Asp Gly Tyr Val Ser Thr 
65                  70                  75                  80  


Ser Ile Ser Leu Arg Ser Ala His Leu Val Gly Gln Thr Ile Leu Ser 
                85                  90                  95      


Gly His Ser Thr Tyr Tyr Ile Tyr Val Ile Ala Thr Ala Pro Asn Met 
            100                 105                 110         


Phe Asn Val Asn Asp Val Leu Gly Ala Tyr Ser Pro His Pro Asp Glu 
        115                 120                 125             


Gln Glu Val Ser Ala Leu Gly Gly Ile Pro Tyr Ser Gln Ile Tyr Gly 
    130                 135                 140                 


Trp Tyr Arg Val His Phe Gly Val Leu Asp Glu Gln Leu His Arg Asn 
145                 150                 155                 160 


Arg Gly Tyr Arg Asp Arg Tyr Tyr Ser Asn Leu Asp Ile Ala Pro Ala 
                165                 170                 175     


Ala Asp Gly Tyr Gly Leu Ala Gly Phe Pro Pro Glu His Arg Ala Trp 
            180                 185                 190         


Arg Glu Glu Pro Trp Ile His His Ala Pro Pro Gly Cys Gly Asn Ala 
        195                 200                 205             


Pro Arg Ser Ser Met Ser Asn Thr Cys Asp Glu Lys Thr Gln Ser Leu 
    210                 215                 220                 


Gly Val Lys Phe Leu Asp Glu Tyr Gln Ser Lys Val Lys Arg Gln Ile 
225                 230                 235                 240 


Phe Ser Gly Tyr Gln Ser Asp Ile Asp Thr His Asn Arg Ile Lys Asp 
                245                 250                 255     


Glu Leu 
        


<210> 68
<211> 124
<212> PRT
<213> Vibrio cholerae

<400> 68
Met Ile Lys Leu Lys Phe Gly Val Phe Phe Thr Val Leu Leu Ser Ser 
1               5                   10                  15      


Ala Tyr Ala His Gly Thr Pro Gln Asn Ile Thr Asp Leu Cys Ala Glu 
            20                  25                  30          


Tyr His Asn Thr Gln Ile His Thr Leu Asn Asp Lys Ile Leu Ser Tyr 
        35                  40                  45              


Thr Glu Ser Leu Ala Gly Asn Arg Glu Met Ala Ile Ile Thr Phe Lys 
    50                  55                  60                  


Asn Gly Ala Thr Phe Gln Val Glu Val Pro Gly Ser Gln His Ile Asp 
65                  70                  75                  80  


Ser Gln Lys Lys Ala Ile Glu Arg Met Lys Asp Thr Leu Arg Ile Ala 
                85                  90                  95      


Tyr Leu Thr Glu Ala Lys Val Glu Lys Leu Cys Val Trp Asn Asn Lys 
            100                 105                 110         


Thr Pro His Ala Ile Ala Ala Ile Ser Met Ala Asn 
        115                 120                 


<210> 69
<211> 18
<212> PRT
<213> Homo sapiens

<400> 69
Asp Pro Asn Ala Pro Lys Arg Pro Pro Ser Ala Phe Phe Leu Phe Cys 
1               5                   10                  15      


Ser Glu 
        


<210> 70
<211> 96
<212> PRT
<213> Homo sapiens

<400> 70
Met Cys Cys Thr Lys Ser Leu Leu Leu Ala Ala Leu Met Ser Val Leu 
1               5                   10                  15      


Leu Leu His Leu Cys Gly Glu Ser Glu Ala Ala Ser Asn Phe Asp Cys 
            20                  25                  30          


Cys Leu Gly Tyr Thr Asp Arg Ile Leu His Pro Lys Phe Ile Val Gly 
        35                  40                  45              


Phe Thr Arg Gln Leu Ala Asn Glu Gly Cys Asp Ile Asn Ala Ile Ile 
    50                  55                  60                  


Phe His Thr Lys Lys Lys Leu Ser Val Cys Ala Asn Pro Lys Gln Thr 
65                  70                  75                  80  


Trp Val Lys Tyr Ile Val Arg Leu Leu Ser Lys Lys Val Lys Asn Met 
                85                  90                  95      


<210> 71
<211> 92
<212> PRT
<213> Homo sapiens

<400> 71
Met Gln Val Ser Thr Ala Ala Leu Ala Val Leu Leu Cys Thr Met Ala 
1               5                   10                  15      


Leu Cys Asn Gln Phe Ser Ala Ser Leu Ala Ala Asp Thr Pro Thr Ala 
            20                  25                  30          


Cys Cys Phe Ser Tyr Thr Ser Arg Gln Ile Pro Gln Asn Phe Ile Ala 
        35                  40                  45              


Asp Tyr Phe Glu Thr Ser Ser Gln Cys Ser Lys Pro Gly Val Ile Phe 
    50                  55                  60                  


Leu Thr Lys Arg Ser Arg Gln Val Cys Ala Asp Pro Ser Glu Glu Trp 
65                  70                  75                  80  


Val Gln Lys Tyr Val Ser Asp Leu Glu Leu Ser Ala 
                85                  90          


<210> 72
<211> 144
<212> PRT
<213> Homo sapiens

<400> 72
Met Trp Leu Gln Ser Leu Leu Leu Leu Gly Thr Val Ala Cys Ser Ile 
1               5                   10                  15      


Ser Ala Pro Ala Arg Ser Pro Ser Pro Ser Thr Gln Pro Trp Glu His 
            20                  25                  30          


Val Asn Ala Ile Gln Glu Ala Arg Arg Leu Leu Asn Leu Ser Arg Asp 
        35                  40                  45              


Thr Ala Ala Glu Met Asn Glu Thr Val Glu Val Ile Ser Glu Met Phe 
    50                  55                  60                  


Asp Leu Gln Glu Pro Thr Cys Leu Gln Thr Arg Leu Glu Leu Tyr Lys 
65                  70                  75                  80  


Gln Gly Leu Arg Gly Ser Leu Thr Lys Leu Lys Gly Pro Leu Thr Met 
                85                  90                  95      


Met Ala Ser His Tyr Lys Gln His Cys Pro Pro Thr Pro Glu Thr Ser 
            100                 105                 110         


Cys Ala Thr Gln Ile Ile Thr Phe Glu Ser Phe Lys Glu Asn Leu Lys 
        115                 120                 125             


Asp Phe Leu Leu Val Ile Pro Phe Asp Cys Trp Glu Pro Val Gln Glu 
    130                 135                 140                 


<210> 73
<211> 204
<212> PRT
<213> Homo sapiens

<400> 73
Met Ala Gly Pro Ala Thr Gln Ser Pro Met Lys Leu Met Ala Leu Gln 
1               5                   10                  15      


Leu Leu Leu Trp His Ser Ala Leu Trp Thr Val Gln Glu Ala Thr Pro 
            20                  25                  30          


Leu Gly Pro Ala Ser Ser Leu Pro Gln Ser Phe Leu Leu Lys Cys Leu 
        35                  40                  45              


Glu Gln Val Arg Lys Ile Gln Gly Asp Gly Ala Ala Leu Gln Glu Lys 
    50                  55                  60                  


Leu Cys Ala Thr Tyr Lys Leu Cys His Pro Glu Glu Leu Val Leu Leu 
65                  70                  75                  80  


Gly His Ser Leu Gly Ile Pro Trp Ala Pro Leu Ser Ser Cys Pro Ser 
                85                  90                  95      


Gln Ala Leu Gln Leu Ala Gly Cys Leu Ser Gln Leu His Ser Gly Leu 
            100                 105                 110         


Phe Leu Tyr Gln Gly Leu Leu Gln Ala Leu Glu Gly Ile Ser Pro Glu 
        115                 120                 125             


Leu Gly Pro Thr Leu Asp Thr Leu Gln Leu Asp Val Ala Asp Phe Ala 
    130                 135                 140                 


Thr Thr Ile Trp Gln Gln Met Glu Glu Leu Gly Met Ala Pro Ala Leu 
145                 150                 155                 160 


Gln Pro Thr Gln Gly Ala Met Pro Ala Phe Ala Ser Ala Phe Gln Arg 
                165                 170                 175     


Arg Ala Gly Gly Val Leu Val Ala Ser His Leu Gln Ser Phe Leu Glu 
            180                 185                 190         


Val Ser Tyr Arg Val Leu Arg His Leu Ala Gln Pro 
        195                 200                 


<210> 74
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 74
Gln Glu Ile Asn Ser Ser Tyr 
1               5           


<210> 75
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 75
Ser His Pro Arg Leu Ser Ala 
1               5           


<210> 76
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 76
Ser Met Pro Asn Pro Met Val 
1               5           


<210> 77
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 77
Gly Leu Gln Gln Val Leu Leu 
1               5           


<210> 78
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 78
His Glu Leu Ser Val Leu Leu 
1               5           


<210> 79
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 79
Tyr Ala Pro Gln Arg Leu Pro 
1               5           


<210> 80
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 80
Thr Pro Arg Thr Leu Pro Thr 
1               5           


<210> 81
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 81
Ala Pro Val His Ser Ser Ile 
1               5           


<210> 82
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 82
Ala Pro Pro His Ala Leu Ser 
1               5           


<210> 83
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 83
Thr Phe Ser Asn Arg Phe Ile 
1               5           


<210> 84
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 84
Val Val Pro Thr Pro Pro Tyr 
1               5           


<210> 85
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 85
Glu Leu Ala Pro Asp Ser Pro 
1               5           


<210> 86
<211> 69
<212> PRT
<213> Shigella dysenteria 1

<400> 86
Thr Pro Asp Cys Val Thr Gly Lys Val Glu Tyr Thr Lys Tyr Asn Asp 
1               5                   10                  15      


Asp Asp Thr Phe Thr Val Lys Val Gly Asp Lys Glu Leu Phe Thr Asn 
            20                  25                  30          


Arg Trp Asn Leu Gln Ser Leu Leu Leu Ser Ala Gln Ile Thr Gly Met 
        35                  40                  45              


Thr Val Thr Ile Lys Gln Asn Ala Cys His Asn Gly Gly Gly Phe Ser 
    50                  55                  60                  


Glu Val Ile Phe Arg 
65                  


<210> 87
<211> 560
<212> PRT
<213> Corynephage omega

<400> 87
Met Ser Arg Lys Leu Phe Ala Ser Ile Leu Ile Gly Ala Leu Leu Gly 
1               5                   10                  15      


Ile Gly Ala Pro Pro Ser Ala His Ala Gly Ala Asp Asp Val Val Asp 
            20                  25                  30          


Ser Ser Lys Ser Phe Val Met Glu Asn Phe Ser Ser Tyr His Gly Thr 
        35                  40                  45              


Lys Pro Gly Tyr Val Asp Ser Ile Gln Lys Gly Ile Gln Lys Pro Lys 
    50                  55                  60                  


Ser Gly Thr Gln Gly Asn Tyr Asp Asp Asp Trp Lys Gly Phe Tyr Ser 
65                  70                  75                  80  


Thr Asp Asn Lys Tyr Asp Ala Ala Gly Tyr Ser Val Asp Asn Glu Asn 
                85                  90                  95      


Pro Leu Ser Gly Lys Ala Gly Gly Val Val Lys Val Thr Tyr Pro Gly 
            100                 105                 110         


Leu Thr Lys Val Leu Ala Leu Lys Val Asp Asn Ala Glu Thr Ile Lys 
        115                 120                 125             


Lys Glu Leu Gly Leu Ser Leu Thr Glu Pro Leu Met Glu Gln Val Gly 
    130                 135                 140                 


Thr Glu Glu Phe Ile Lys Arg Phe Gly Asp Gly Ala Ser Arg Val Val 
145                 150                 155                 160 


Leu Ser Leu Pro Phe Ala Glu Gly Ser Ser Ser Val Glu Tyr Ile Asn 
                165                 170                 175     


Asn Trp Glu Gln Ala Lys Ala Leu Ser Val Glu Leu Glu Ile Asn Phe 
            180                 185                 190         


Glu Thr Arg Gly Lys Arg Gly Gln Asp Ala Met Tyr Glu Tyr Met Ala 
        195                 200                 205             


Gln Ala Cys Ala Gly Asn Arg Val Arg Arg Ser Val Gly Ser Ser Leu 
    210                 215                 220                 


Ser Cys Ile Asn Leu Asp Trp Asp Val Ile Arg Asp Lys Thr Lys Thr 
225                 230                 235                 240 


Lys Ile Glu Ser Leu Lys Glu His Gly Pro Ile Lys Asn Lys Met Ser 
                245                 250                 255     


Glu Ser Pro Asn Lys Thr Val Ser Glu Glu Lys Ala Lys Gln Tyr Leu 
            260                 265                 270         


Glu Glu Phe His Gln Thr Ala Leu Glu His Pro Glu Leu Ser Glu Leu 
        275                 280                 285             


Lys Thr Val Thr Gly Thr Asn Pro Val Phe Ala Gly Ala Asn Tyr Ala 
    290                 295                 300                 


Ala Trp Ala Val Asn Val Ala Gln Val Ile Asp Ser Glu Thr Ala Asp 
305                 310                 315                 320 


Asn Leu Glu Lys Thr Thr Ala Ala Leu Ser Ile Leu Pro Gly Ile Gly 
                325                 330                 335     


Ser Val Met Gly Ile Ala Asp Gly Ala Val His His Asn Thr Glu Glu 
            340                 345                 350         


Ile Val Ala Gln Ser Ile Ala Leu Ser Ser Leu Met Val Ala Gln Ala 
        355                 360                 365             


Ile Pro Leu Val Gly Glu Leu Val Asp Ile Gly Phe Ala Ala Tyr Asn 
    370                 375                 380                 


Phe Val Glu Ser Ile Ile Asn Leu Phe Gln Val Val His Asn Ser Tyr 
385                 390                 395                 400 


Asn Arg Pro Ala Tyr Ser Pro Gly His Lys Thr Gln Pro Phe Leu His 
                405                 410                 415     


Asp Gly Tyr Ala Val Ser Trp Asn Thr Val Glu Asp Ser Ile Ile Arg 
            420                 425                 430         


Thr Gly Phe Gln Gly Glu Ser Gly His Asp Ile Lys Ile Thr Ala Glu 
        435                 440                 445             


Asn Thr Pro Leu Pro Ile Ala Gly Val Leu Leu Pro Thr Ile Pro Gly 
    450                 455                 460                 


Lys Leu Asp Val Asn Lys Ser Lys Thr His Ile Ser Val Asn Gly Arg 
465                 470                 475                 480 


Lys Ile Arg Met Arg Cys Arg Ala Ile Asp Gly Asp Val Thr Phe Cys 
                485                 490                 495     


Arg Pro Lys Ser Pro Val Tyr Val Gly Asn Gly Val His Ala Asn Leu 
            500                 505                 510         


His Val Ala Phe His Arg Ser Ser Ser Glu Lys Ile His Ser Asn Glu 
        515                 520                 525             


Ile Ser Ser Asp Ser Ile Gly Val Leu Gly Tyr Gln Lys Thr Val Asp 
    530                 535                 540                 


His Thr Lys Val Asn Ser Lys Leu Ser Leu Phe Phe Glu Ile Lys Ser 
545                 550                 555                 560 


<210> 88
<211> 114
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 88
Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile 
1               5                   10                  15      


Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val His 
            20                  25                  30          


Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu Gln 
        35                  40                  45              


Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val Glu 
    50                  55                  60                  


Asn Leu Ile Ile Leu Ala Asn Asp Ser Leu Ser Ser Asn Gly Asn Val 
65                  70                  75                  80  


Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile 
                85                  90                  95      


Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile Asn 
            100                 105                 110         


Thr Ser 
        


<210> 89
<211> 297
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 89
Ile Thr Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val 
1               5                   10                  15      


Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly 
            20                  25                  30          


Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn 
        35                  40                  45              


Lys Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile 
    50                  55                  60                  


Arg Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
65                  70                  75                  80  


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
                85                  90                  95      


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            100                 105                 110         


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        115                 120                 125             


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    130                 135                 140                 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
145                 150                 155                 160 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                165                 170                 175     


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            180                 185                 190         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
        195                 200                 205             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    210                 215                 220                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
225                 230                 235                 240 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                245                 250                 255     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            260                 265                 270         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        275                 280                 285             


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    290                 295         


<210> 90
<211> 535
<212> PRT
<213> Corynebacterium diphtheriae

<400> 90
Gly Ala Asp Asp Val Val Asp Ser Ser Lys Ser Phe Val Met Glu Asn 
1               5                   10                  15      


Phe Ser Ser Tyr His Gly Thr Lys Pro Gly Tyr Val Asp Ser Ile Gln 
            20                  25                  30          


Lys Gly Ile Gln Lys Pro Lys Ser Gly Thr Gln Gly Asn Tyr Asp Asp 
        35                  40                  45              


Asp Trp Lys Glu Phe Tyr Ser Thr Asp Asn Lys Tyr Asp Ala Ala Gly 
    50                  55                  60                  


Tyr Ser Val Asp Asn Glu Asn Pro Leu Ser Gly Lys Ala Gly Gly Val 
65                  70                  75                  80  


Val Lys Val Thr Tyr Pro Gly Leu Thr Lys Val Leu Ala Leu Lys Val 
                85                  90                  95      


Asp Asn Ala Glu Thr Ile Lys Lys Glu Leu Gly Leu Ser Leu Thr Glu 
            100                 105                 110         


Pro Leu Met Glu Gln Val Gly Thr Glu Glu Phe Ile Lys Arg Phe Gly 
        115                 120                 125             


Asp Gly Ala Ser Arg Val Val Leu Ser Leu Pro Phe Ala Glu Gly Ser 
    130                 135                 140                 


Ser Ser Val Glu Tyr Ile Asn Asn Trp Glu Gln Ala Lys Ala Leu Ser 
145                 150                 155                 160 


Val Glu Leu Glu Ile Asn Phe Glu Thr Arg Gly Lys Arg Gly Gln Asp 
                165                 170                 175     


Ala Met Tyr Glu Tyr Met Ala Gln Ala Cys Ala Gly Asn Arg Val Arg 
            180                 185                 190         


Arg Ser Val Gly Ser Ser Leu Ser Cys Ile Asn Leu Asp Trp Asp Val 
        195                 200                 205             


Ile Arg Asp Lys Thr Lys Thr Lys Ile Glu Ser Leu Lys Glu His Gly 
    210                 215                 220                 


Pro Ile Lys Asn Lys Met Ser Glu Ser Pro Asn Lys Thr Val Ser Glu 
225                 230                 235                 240 


Glu Lys Ala Lys Gln Tyr Leu Glu Glu Phe His Gln Thr Ala Leu Glu 
                245                 250                 255     


His Pro Glu Leu Ser Glu Leu Lys Thr Val Thr Gly Thr Asn Pro Val 
            260                 265                 270         


Phe Ala Gly Ala Asn Tyr Ala Ala Trp Ala Val Asn Val Ala Gln Val 
        275                 280                 285             


Ile Asp Ser Glu Thr Ala Asp Asn Leu Glu Lys Thr Thr Ala Ala Leu 
    290                 295                 300                 


Ser Ile Leu Pro Gly Ile Gly Ser Val Met Gly Ile Ala Asp Gly Ala 
305                 310                 315                 320 


Val His His Asn Thr Glu Glu Ile Val Ala Gln Ser Ile Ala Leu Ser 
                325                 330                 335     


Ser Leu Met Val Ala Gln Ala Ile Pro Leu Val Gly Glu Leu Val Asp 
            340                 345                 350         


Ile Gly Phe Ala Ala Tyr Asn Phe Val Glu Ser Ile Ile Asn Leu Phe 
        355                 360                 365             


Gln Val Val His Asn Ser Tyr Asn Arg Pro Ala Tyr Ser Pro Gly His 
    370                 375                 380                 


Lys Thr Gln Pro Phe Leu His Asp Gly Tyr Ala Val Ser Trp Asn Thr 
385                 390                 395                 400 


Val Glu Asp Ser Ile Ile Arg Thr Gly Phe Gln Gly Glu Ser Gly His 
                405                 410                 415     


Asp Ile Lys Ile Thr Ala Glu Asn Thr Pro Leu Pro Ile Ala Gly Val 
            420                 425                 430         


Leu Leu Pro Thr Ile Pro Gly Lys Leu Asp Val Asn Lys Ser Lys Thr 
        435                 440                 445             


His Ile Ser Val Asn Gly Arg Lys Ile Arg Met Arg Cys Arg Ala Ile 
    450                 455                 460                 


Asp Gly Asp Val Thr Phe Cys Arg Pro Lys Ser Pro Val Tyr Val Gly 
465                 470                 475                 480 


Asn Gly Val His Ala Asn Leu His Val Ala Phe His Arg Ser Ser Ser 
                485                 490                 495     


Glu Lys Ile His Ser Asn Glu Ile Ser Ser Asp Ser Ile Gly Val Leu 
            500                 505                 510         


Gly Tyr Gln Lys Thr Val Asp His Thr Lys Val Asn Ser Lys Leu Ser 
        515                 520                 525             


Leu Phe Phe Glu Ile Lys Ser 
    530                 535 


<210> 91
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 91
Met Ala Val Pro Met Gln Leu Ser Cys Ser Arg 
1               5                   10      


<210> 92
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 92
Arg Ser Thr Gly 
1               


<210> 93
<211> 2
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 93
Thr Arg 
1       


<210> 94
<211> 3
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 94
Arg Ser Gln 
1           


<210> 95
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 95
Arg Ser Ala Gly Glu 
1               5   


<210> 96
<211> 2
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 96
Arg Ser 
1       


<210> 97
<211> 2
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 97
Gly Gly 
1       


<210> 98
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 98
Gly Ser Gly Gly Ser Gly Gly Ser Gly 
1               5                   


<210> 99
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 99
Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly 
1               5                   10      


<210> 100
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 100
Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly 
1               5                   10                  


<210> 101
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 101
Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly 
1               5                   10                  15      


Gly 
    


<210> 102
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 102
Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly 
1               5                   10                  15      


Gly Ser Gly Gly 
            20  


<210> 103
<211> 23
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 103
Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly 
1               5                   10                  15      


Gly Ser Gly Gly Ser Gly Gly 
            20              


<210> 104
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 104
Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly 
1               5                   10                  15      


<210> 105
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 105
Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly 
1               5                   10                  15      


<210> 106
<211> 2109
<212> DNA
<213> Homo sapiens

<400> 106
atggagtctc cctcggcccc tccccacaga tggtgcatcc cctggcagag gctcctgctc       60

acagcctcac ttctaacctt ctggaacccg cccaccactg ccaagctcac tattgaatcc      120

acgccgttca atgtcgcaga ggggaaggag gtgcttctac ttgtccacaa tctgccccag      180

catctttttg gctacagctg gtacaaaggt gaaagagtgg atggcaaccg tcaaattata      240

ggatatgtaa taggaactca acaagctacc ccagggcccg catacagtgg tcgagagata      300

atatacccca atgcatccct gctgatccag aacatcatcc agaatgacac aggattctac      360

accctacacg tcataaagtc agatcttgtg aatgaagaag caactggcca gttccgggta      420

tacccggagc tgcccaagcc ctccatctcc agcaacaact ccaaacccgt ggaggacaag      480

gatgctgtgg ccttcacctg tgaacctgag actcaggacg caacctacct gtggtgggta      540

aacaatcaga gcctcccggt cagtcccagg ctgcagctgt ccaatggcaa caggaccctc      600

actctattca atgtcacaag aaatgacaca gcaagctaca aatgtgaaac ccagaaccca      660

gtgagtgcca ggcgcagtga ttcagtcatc ctgaatgtcc tctatggccc ggatgccccc      720

accatttccc ctctaaacac atcttacaga tcaggggaaa atctgaacct ctcctgccac      780

gcagcctcta acccacctgc acagtactct tggtttgtca atgggacttt ccagcaatcc      840

acccaagagc tctttatccc caacatcact gtgaataata gtggatccta tacgtgccaa      900

gcccataact cagacactgg cctcaatagg accacagtca cgacgatcac agtctatgca      960

gagccaccca aacccttcat caccagcaac aactccaacc ccgtggagga tgaggatgct     1020

gtagccttaa cctgtgaacc tgagattcag aacacaacct acctgtggtg ggtaaataat     1080

cagagcctcc cggtcagtcc caggctgcag ctgtccaatg acaacaggac cctcactcta     1140

ctcagtgtca caaggaatga tgtaggaccc tatgagtgtg gaatccagaa cgaattaagt     1200

gttgaccaca gcgacccagt catcctgaat gtcctctatg gcccagacga ccccaccatt     1260

tccccctcat acacctatta ccgtccaggg gtgaacctca gcctctcctg ccatgcagcc     1320

tctaacccac ctgcacagta ttcttggctg attgatggga acatccagca acacacacaa     1380

gagctcttta tctccaacat cactgagaag aacagcggac tctatacctg ccaggccaat     1440

aactcagcca gtggccacag caggactaca gtcaagacaa tcacagtctc tgcggagctg     1500

cccaagccct ccatctccag caacaactcc aaacccgtgg aggacaagga tgctgtggcc     1560

ttcacctgtg aacctgaggc tcagaacaca acctacctgt ggtgggtaaa tggtcagagc     1620

ctcccagtca gtcccaggct gcagctgtcc aatggcaaca ggaccctcac tctattcaat     1680

gtcacaagaa atgacgcaag agcctatgta tgtggaatcc agaactcagt gagtgcaaac     1740

cgcagtgacc cagtcaccct ggatgtcctc tatgggccgg acacccccat catttccccc     1800

ccagactcgt cttacctttc gggagcggac ctcaacctct cctgccactc ggcctctaac     1860

ccatccccgc agtattcttg gcgtatcaat gggataccgc agcaacacac acaagttctc     1920

tttatcgcca aaatcacgcc aaataataac gggacctatg cctgttttgt ctctaacttg     1980

gctactggcc gcaataattc catagtcaag agcatcacag tctctgcatc tggaacttct     2040

cctggtctct cagctggggc cactgtcggc atcatgattg gagtgctggt tggggttgct     2100

ctgatatag                                                             2109


<210> 107
<211> 1428
<212> DNA
<213> Homo sapiens

<400> 107
atgacaccgg gcacccagtc tcctttcttc ctgctgctgc tcctcacagt gcttacagtt       60

gttacgggtt ctggtcatgc aagctctacc ccaggtggag aaaaggagac ttcggctacc      120

cagagaagtt cagtgcccag ctctactgag aagaatgctg tgagtatgac cagcagcgta      180

ctctccagcc acagccccgg ttcaggctcc tccaccactc agggacagga tgtcactctg      240

gccccggcca cggaaccagc ttcaggttca gctgcccttt ggggacagga tgtcacctcg      300

gtcccagtca ccaggccagc cctgggctcc accaccccgc cagcccacga tgtcacctca      360

gccccggaca acaagccagc cccgggctcc accgcccccc cagcccacgg tgtcacctcg      420

tatcttgaca ccaggccggc cccggtttat cttgcccccc cagcccatgg tgtcacctcg      480

gccccggaca acaggcccgc cttgggctcc accgcccctc cagtccacaa tgtcacctcg      540

gcctcaggct ctgcatcagg ctcagcttct actctggtgc acaacggcac ctctgccagg      600

gctaccacaa ccccagccag caagagcact ccattctcaa ttcccagcca ccactctgat      660

actcctacca cccttgccag ccatagcacc aagactgatg ccagtagcac tcaccatagc      720

acggtacctc ctctcacctc ctccaatcac agcacttctc cccagttgtc tactggggtc      780

tctttctttt tcctgtcttt tcacatttca aacctccagt ttaattcctc tctggaagat      840

cccagcaccg actactacca agagctgcag agagacattt ctgaaatgtt tttgcagatt      900

tataaacaag ggggttttct gggcctctcc aatattaagt tcaggccagg atctgtggtg      960

gtacaattga ctctggcctt ccgagaaggt accatcaatg tccacgacgt ggagacacag     1020

ttcaatcagt ataaaacgga agcagcctct cgatataacc tgacgatctc agacgtcagc     1080

gtgagtgatg tgccatttcc tttctctgcc cagtctgggg ctggggtgcc aggctggggc     1140

atcgcgctgc tggtgctggt ctgtgttctg gtttatctgg ccattgtcta tctcattgcc     1200

ttggctgtcg ctcaggttcg ccgaaagaac tacgggcagc tggacatctt tccagcccgg     1260

gataaatacc atcctatgag cgagtacgct ctttaccaca cccatgggcg ctatgtgccc     1320

cctagcagtc ttttccgtag cccctatgag aaggtttctg caggtaatgg tggcagctat     1380

ctctcttaca caaacccagc agtggcagcc gcttctgcca acttgtag                  1428


<210> 108
<211> 1233
<212> DNA
<213> Homo sapiens

<400> 108
atgagctccc ctggcaccga gagcgcggga aagagcctgc agtaccgagt ggaccacctg       60

ctgagcgccg tggagaatga gctgcaggcg ggcagcgaga agggcgaccc cacagagcgc      120

gaactgcgcg tgggcctgga ggagagcgag ctgtggctgc gcttcaagga gctcaccaat      180

gagatgatcg tgaccaagaa cggcaggagg atgtttccgg tgctgaaggt gaacgtgtct      240

ggcctggacc ccaacgccat gtactccttc ctgctggact tcgtggcggc ggacaaccac      300

cgctggaagt acgtgaacgg ggaatgggtg ccggggggca agccggagcc gcaggcgccc      360

agctgcgtct acatccaccc cgactcgccc aacttcgggg cccactggat gaaggctccc      420

gtctccttca gcaaagtcaa gctcaccaac aagctcaacg gagggggcca gatcatgctg      480

aactccttgc ataagtatga gcctcgaatc cacatagtga gagttggggg tccacagcgc      540

atgatcacca gccactgctt ccctgagacc cagttcatag cggtgactgc tagaagtgat      600

cacaaagaga tgatggagga acccggagac agccagcaac ctgggtactc ccaatggggg      660

tggcttcttc ctggaaccag caccgtgtgt ccacctgcaa atcctcatcc tcagtttgga      720

ggtgccctct ccctcccctc cacgcacagc tgtgacaggt acccaaccct gaggagccac      780

cggtcctcac cctaccccag cccctatgct catcggaaca attctccaac ctattctgac      840

aactcacctg catgtttatc catgctgcaa tcccatgaca attggtccag ccttggaatg      900

cctgcccatc ccagcatgct ccccgtgagc cacaatgcca gcccacctac cagctccagt      960

cagtacccca gcctgtggtc tgtgagcaac ggcgccgtca ccccgggctc ccaggcagca     1020

gccgtgtcca acgggctggg ggcccagttc ttccggggct cccccgcgca ctacacaccc     1080

ctcacccatc cggtctcggc gccctcttcc tcgggatccc cactgtacga aggggcggcc     1140

gcggccacag acatcgtgga cagccagtac gacgccgcag cccaaggccg cctcatagcc     1200

tcatggacac ctgtgtcgcc accttccatg tga                                  1233


<210> 109
<211> 1331
<212> PRT
<213> Homo sapiens

<400> 109
Met Glu Ser His Ser Arg Ala Gly Lys Ser Arg Lys Ser Ala Lys Phe 
1               5                   10                  15      


Arg Ser Ile Ser Arg Ser Leu Met Leu Cys Asn Ala Lys Thr Ser Asp 
            20                  25                  30          


Asp Gly Ser Ser Pro Asp Glu Lys Tyr Pro Asp Pro Phe Glu Ile Ser 
        35                  40                  45              


Leu Ala Gln Gly Lys Glu Gly Ile Phe His Ser Ser Val Gln Leu Ala 
    50                  55                  60                  


Asp Thr Ser Glu Ala Gly Pro Ser Ser Val Pro Asp Leu Ala Leu Ala 
65                  70                  75                  80  


Ser Glu Ala Ala Gln Leu Gln Ala Ala Gly Asn Asp Arg Gly Lys Thr 
                85                  90                  95      


Cys Arg Arg Ile Phe Phe Met Lys Glu Ser Ser Thr Ala Ser Ser Arg 
            100                 105                 110         


Glu Lys Pro Gly Lys Leu Glu Ala Gln Ser Ser Asn Phe Leu Phe Pro 
        115                 120                 125             


Lys Ala Cys His Gln Arg Ala Arg Ser Asn Ser Thr Ser Val Asn Pro 
    130                 135                 140                 


Tyr Cys Thr Arg Glu Ile Asp Phe Pro Met Thr Lys Lys Ser Ala Ala 
145                 150                 155                 160 


Pro Thr Asp Arg Gln Pro Tyr Ser Leu Cys Ser Asn Arg Lys Ser Leu 
                165                 170                 175     


Ser Gln Gln Leu Asp Cys Pro Ala Gly Lys Ala Ala Gly Thr Ser Arg 
            180                 185                 190         


Pro Thr Arg Ser Leu Ser Thr Ala Gln Leu Val Gln Pro Ser Gly Gly 
        195                 200                 205             


Leu Gln Ala Ser Val Ile Ser Asn Ile Val Leu Met Lys Gly Gln Ala 
    210                 215                 220                 


Lys Gly Leu Gly Phe Ser Ile Val Gly Gly Lys Asp Ser Ile Tyr Gly 
225                 230                 235                 240 


Pro Ile Gly Ile Tyr Val Lys Thr Ile Phe Ala Gly Gly Ala Ala Ala 
                245                 250                 255     


Ala Asp Gly Arg Leu Gln Glu Gly Asp Glu Ile Leu Glu Leu Asn Gly 
            260                 265                 270         


Glu Ser Met Ala Gly Leu Thr His Gln Asp Ala Leu Gln Lys Phe Lys 
        275                 280                 285             


Gln Ala Lys Lys Gly Leu Leu Thr Leu Thr Val Arg Thr Arg Leu Thr 
    290                 295                 300                 


Ala Pro Pro Ser Leu Cys Ser His Leu Ser Pro Pro Leu Cys Arg Ser 
305                 310                 315                 320 


Leu Ser Ser Ser Thr Cys Ile Thr Lys Asp Ser Ser Ser Phe Ala Leu 
                325                 330                 335     


Glu Ser Pro Ser Ala Pro Ile Ser Thr Ala Lys Pro Asn Tyr Arg Ile 
            340                 345                 350         


Met Val Glu Val Ser Leu Gln Lys Glu Ala Gly Val Gly Leu Gly Ile 
        355                 360                 365             


Gly Leu Cys Ser Val Pro Tyr Phe Gln Cys Ile Ser Gly Ile Phe Val 
    370                 375                 380                 


His Thr Leu Ser Pro Gly Ser Val Ala His Leu Asp Gly Arg Leu Arg 
385                 390                 395                 400 


Cys Gly Asp Glu Ile Val Glu Ile Ser Asp Ser Pro Val His Cys Leu 
                405                 410                 415     


Thr Leu Asn Glu Val Tyr Thr Ile Leu Ser Arg Cys Asp Pro Gly Pro 
            420                 425                 430         


Val Pro Ile Ile Val Ser Arg His Pro Asp Pro Gln Val Ser Glu Gln 
        435                 440                 445             


Gln Leu Lys Glu Ala Val Ala Gln Ala Val Glu Asn Thr Lys Phe Gly 
    450                 455                 460                 


Lys Glu Arg His Gln Trp Ser Leu Glu Gly Val Lys Arg Leu Glu Ser 
465                 470                 475                 480 


Ser Trp His Gly Arg Pro Thr Leu Glu Lys Glu Arg Glu Lys Asn Ser 
                485                 490                 495     


Ala Pro Pro His Arg Arg Ala Gln Lys Val Met Ile Arg Ser Ser Ser 
            500                 505                 510         


Asp Ser Ser Tyr Met Ser Gly Ser Pro Gly Gly Ser Pro Gly Ser Gly 
        515                 520                 525             


Ser Ala Glu Lys Pro Ser Ser Asp Val Asp Ile Ser Thr His Ser Pro 
    530                 535                 540                 


Ser Leu Pro Leu Ala Arg Glu Pro Val Val Leu Ser Ile Ala Ser Ser 
545                 550                 555                 560 


Arg Leu Pro Gln Glu Ser Pro Pro Leu Pro Glu Ser Arg Asp Ser His 
                565                 570                 575     


Pro Pro Leu Arg Leu Lys Lys Ser Phe Glu Ile Leu Val Arg Lys Pro 
            580                 585                 590         


Met Ser Ser Lys Pro Lys Pro Pro Pro Arg Lys Tyr Phe Lys Ser Asp 
        595                 600                 605             


Ser Asp Pro Gln Lys Ser Leu Glu Glu Arg Glu Asn Ser Ser Cys Ser 
    610                 615                 620                 


Ser Gly His Thr Pro Pro Thr Cys Gly Gln Glu Ala Arg Glu Leu Leu 
625                 630                 635                 640 


Pro Leu Leu Leu Pro Gln Glu Asp Thr Ala Gly Arg Ser Pro Ser Ala 
                645                 650                 655     


Ser Ala Gly Cys Pro Gly Pro Gly Ile Gly Pro Gln Thr Lys Ser Ser 
            660                 665                 670         


Thr Glu Gly Glu Pro Gly Trp Arg Arg Ala Ser Pro Val Thr Gln Thr 
        675                 680                 685             


Ser Pro Ile Lys His Pro Leu Leu Lys Arg Gln Ala Arg Met Asp Tyr 
    690                 695                 700                 


Ser Phe Asp Thr Thr Ala Glu Asp Pro Trp Val Arg Ile Ser Asp Cys 
705                 710                 715                 720 


Ile Lys Asn Leu Phe Ser Pro Ile Met Ser Glu Asn His Gly His Met 
                725                 730                 735     


Pro Leu Gln Pro Asn Ala Ser Leu Asn Glu Glu Glu Gly Thr Gln Gly 
            740                 745                 750         


His Pro Asp Gly Thr Pro Pro Lys Leu Asp Thr Ala Asn Gly Thr Pro 
        755                 760                 765             


Lys Val Tyr Lys Ser Ala Asp Ser Ser Thr Val Lys Lys Gly Pro Pro 
    770                 775                 780                 


Val Ala Pro Lys Pro Ala Trp Phe Arg Gln Ser Leu Lys Gly Leu Arg 
785                 790                 795                 800 


Asn Arg Ala Ser Asp Pro Arg Gly Leu Pro Asp Pro Ala Leu Ser Thr 
                805                 810                 815     


Gln Pro Ala Pro Ala Ser Arg Glu His Leu Gly Ser His Ile Arg Ala 
            820                 825                 830         


Ser Ser Ser Ser Ser Ser Ile Arg Gln Arg Ile Ser Ser Phe Glu Thr 
        835                 840                 845             


Phe Gly Ser Ser Gln Leu Pro Asp Lys Gly Ala Gln Arg Leu Ser Leu 
    850                 855                 860                 


Gln Pro Ser Ser Gly Glu Ala Ala Lys Pro Leu Gly Lys His Glu Glu 
865                 870                 875                 880 


Gly Arg Phe Ser Gly Leu Leu Gly Arg Gly Ala Ala Pro Thr Leu Val 
                885                 890                 895     


Pro Gln Gln Pro Glu Gln Val Leu Ser Ser Gly Ser Pro Ala Ala Ser 
            900                 905                 910         


Glu Ala Arg Asp Pro Gly Val Ser Glu Ser Pro Pro Pro Gly Arg Gln 
        915                 920                 925             


Pro Asn Gln Lys Thr Leu Pro Pro Gly Pro Asp Pro Leu Leu Arg Leu 
    930                 935                 940                 


Leu Ser Thr Gln Ala Glu Glu Ser Gln Gly Pro Val Leu Lys Met Pro 
945                 950                 955                 960 


Ser Gln Arg Ala Arg Ser Phe Pro Leu Thr Arg Ser Gln Ser Cys Glu 
                965                 970                 975     


Thr Lys Leu Leu Asp Glu Lys Thr Ser Lys Leu Tyr Ser Ile Ser Ser 
            980                 985                 990         


Gln Val Ser Ser Ala Val Met Lys  Ser Leu Leu Cys Leu  Pro Ser Ser 
        995                 1000                 1005             


Ile Ser  Cys Ala Gln Thr Pro  Cys Ile Pro Lys Glu  Gly Ala Ser 
    1010                 1015                 1020             


Pro Thr  Ser Ser Ser Asn Glu  Asp Ser Ala Ala Asn  Gly Ser Ala 
    1025                 1030                 1035             


Glu Thr  Ser Ala Leu Asp Thr  Gly Phe Ser Leu Asn  Leu Ser Glu 
    1040                 1045                 1050             


Leu Arg  Glu Tyr Thr Glu Gly  Leu Thr Glu Ala Lys  Glu Asp Asp 
    1055                 1060                 1065             


Asp Gly  Asp His Ser Ser Leu  Gln Ser Gly Gln Ser  Val Ile Ser 
    1070                 1075                 1080             


Leu Leu  Ser Ser Glu Glu Leu  Lys Lys Leu Ile Glu  Glu Val Lys 
    1085                 1090                 1095             


Val Leu  Asp Glu Ala Thr Leu  Lys Gln Leu Asp Gly  Ile His Val 
    1100                 1105                 1110             


Thr Ile  Leu His Lys Glu Glu  Gly Ala Gly Leu Gly  Phe Ser Leu 
    1115                 1120                 1125             


Ala Gly  Gly Ala Asp Leu Glu  Asn Lys Val Ile Thr  Val His Arg 
    1130                 1135                 1140             


Val Phe  Pro Asn Gly Leu Ala  Ser Gln Glu Gly Thr  Ile Gln Lys 
    1145                 1150                 1155             


Gly Asn  Glu Val Leu Ser Ile  Asn Gly Lys Ser Leu  Lys Gly Thr 
    1160                 1165                 1170             


Thr His  His Asp Ala Leu Ala  Ile Leu Arg Gln Ala  Arg Glu Pro 
    1175                 1180                 1185             


Arg Gln  Ala Val Ile Val Thr  Arg Lys Leu Thr Pro  Glu Ala Met 
    1190                 1195                 1200             


Pro Asp  Leu Asn Ser Ser Thr  Asp Ser Ala Ala Ser  Ala Ser Ala 
    1205                 1210                 1215             


Ala Ser  Asp Val Ser Val Glu  Ser Thr Glu Ala Thr  Val Cys Thr 
    1220                 1225                 1230             


Val Thr  Leu Glu Lys Met Ser  Ala Gly Leu Gly Phe  Ser Leu Glu 
    1235                 1240                 1245             


Gly Gly  Lys Gly Ser Leu His  Gly Asp Lys Pro Leu  Thr Ile Asn 
    1250                 1255                 1260             


Arg Ile  Phe Lys Gly Ala Ala  Ser Glu Gln Ser Glu  Thr Val Gln 
    1265                 1270                 1275             


Pro Gly  Asp Glu Ile Leu Gln  Leu Gly Gly Thr Ala  Met Gln Gly 
    1280                 1285                 1290             


Leu Thr  Arg Phe Glu Ala Trp  Asn Ile Ile Lys Ala  Leu Pro Asp 
    1295                 1300                 1305             


Gly Pro  Val Thr Ile Val Ile  Arg Arg Lys Ser Leu  Gln Ser Lys 
    1310                 1315                 1320             


Glu Thr  Thr Ala Ala Gly Asp  Ser 
    1325                 1330     


<210> 110
<211> 155
<212> PRT
<213> Homo sapiens

<400> 110
Met Thr Pro Gly Lys Thr Ser Leu Val Ser Leu Leu Leu Leu Leu Ser 
1               5                   10                  15      


Leu Glu Ala Ile Val Lys Ala Gly Ile Thr Ile Pro Arg Asn Pro Gly 
            20                  25                  30          


Cys Pro Asn Ser Glu Asp Lys Asn Phe Pro Arg Thr Val Met Val Asn 
        35                  40                  45              


Leu Asn Ile His Asn Arg Asn Thr Asn Thr Asn Pro Lys Arg Ser Ser 
    50                  55                  60                  


Asp Tyr Tyr Asn Arg Ser Thr Ser Pro Trp Asn Leu His Arg Asn Glu 
65                  70                  75                  80  


Asp Pro Glu Arg Tyr Pro Ser Val Ile Trp Glu Ala Lys Cys Arg His 
                85                  90                  95      


Leu Gly Cys Ile Asn Ala Asp Gly Asn Val Asp Tyr His Met Asn Ser 
            100                 105                 110         


Val Pro Ile Gln Gln Glu Ile Leu Val Leu Arg Arg Glu Pro Pro His 
        115                 120                 125             


Cys Pro Asn Ser Phe Arg Leu Glu Lys Ile Leu Val Ser Val Gly Cys 
    130                 135                 140                 


Thr Cys Val Thr Pro Ile Val His His Val Ala 
145                 150                 155 


<210> 111
<211> 476
<212> PRT
<213> Homo sapiens

<400> 111
Arg Ala Val Pro Gly Gly Ser Ser Pro Ala Trp Thr Gln Cys Gln Gln 
1               5                   10                  15      


Leu Ser Gln Lys Leu Cys Thr Leu Ala Trp Ser Ala His Pro Leu Val 
            20                  25                  30          


Gly His Met Asp Leu Arg Glu Glu Gly Asp Glu Glu Thr Thr Asn Asp 
        35                  40                  45              


Val Pro His Ile Gln Cys Gly Asp Gly Cys Asp Pro Gln Gly Leu Arg 
    50                  55                  60                  


Asp Asn Ser Gln Phe Cys Leu Gln Arg Ile His Gln Gly Leu Ile Phe 
65                  70                  75                  80  


Tyr Glu Lys Leu Leu Gly Ser Asp Ile Phe Thr Gly Glu Pro Ser Leu 
                85                  90                  95      


Leu Pro Asp Ser Pro Val Gly Gln Leu His Ala Ser Leu Leu Gly Leu 
            100                 105                 110         


Ser Gln Leu Leu Gln Pro Glu Gly His His Trp Glu Thr Gln Gln Ile 
        115                 120                 125             


Pro Ser Leu Ser Pro Ser Gln Pro Trp Gln Arg Leu Leu Leu Arg Phe 
    130                 135                 140                 


Lys Ile Leu Arg Ser Leu Gln Ala Phe Val Ala Val Ala Ala Arg Val 
145                 150                 155                 160 


Phe Ala His Gly Ala Ala Thr Leu Ser Pro Ile Trp Glu Leu Lys Lys 
                165                 170                 175     


Asp Val Tyr Val Val Glu Leu Asp Trp Tyr Pro Asp Ala Pro Gly Glu 
            180                 185                 190         


Met Val Val Leu Thr Cys Asp Thr Pro Glu Glu Asp Gly Ile Thr Trp 
        195                 200                 205             


Thr Leu Asp Gln Ser Ser Glu Val Leu Gly Ser Gly Lys Thr Leu Thr 
    210                 215                 220                 


Ile Gln Val Lys Glu Phe Gly Asp Ala Gly Gln Tyr Thr Cys His Lys 
225                 230                 235                 240 


Gly Gly Glu Val Leu Ser His Ser Leu Leu Leu Leu His Lys Lys Glu 
                245                 250                 255     


Asp Gly Ile Trp Ser Thr Asp Ile Leu Lys Asp Gln Lys Glu Pro Lys 
            260                 265                 270         


Asn Lys Thr Phe Leu Arg Cys Glu Ala Lys Asn Tyr Ser Gly Arg Phe 
        275                 280                 285             


Thr Cys Trp Trp Leu Thr Thr Ile Ser Thr Asp Leu Thr Phe Ser Val 
    290                 295                 300                 


Lys Ser Ser Arg Gly Ser Ser Asp Pro Gln Gly Val Thr Cys Gly Ala 
305                 310                 315                 320 


Ala Thr Leu Ser Ala Glu Arg Val Arg Gly Asp Asn Lys Glu Tyr Glu 
                325                 330                 335     


Tyr Ser Val Glu Cys Gln Glu Asp Ser Ala Cys Pro Ala Ala Glu Glu 
            340                 345                 350         


Ser Leu Pro Ile Glu Val Met Val Asp Ala Val His Lys Leu Lys Tyr 
        355                 360                 365             


Glu Asn Tyr Thr Ser Ser Phe Phe Ile Arg Asp Ile Ile Lys Pro Asp 
    370                 375                 380                 


Pro Pro Lys Asn Leu Gln Leu Lys Pro Leu Lys Asn Ser Arg Gln Val 
385                 390                 395                 400 


Glu Val Ser Trp Glu Tyr Pro Asp Thr Trp Ser Thr Pro His Ser Tyr 
                405                 410                 415     


Phe Ser Leu Thr Phe Cys Val Gln Val Gln Gly Lys Ser Lys Arg Glu 
            420                 425                 430         


Lys Lys Asp Arg Val Phe Thr Asp Lys Thr Ser Ala Thr Val Ile Cys 
        435                 440                 445             


Arg Lys Asn Ala Ser Ile Ser Val Arg Ala Gln Asp Arg Tyr Tyr Ser 
    450                 455                 460                 


Ser Ser Trp Ser Glu Trp Ala Ser Val Pro Cys Ser 
465                 470                 475     


<210> 112
<211> 234
<212> PRT
<213> Homo sapiens

<400> 112
Met Cys Phe Pro Lys Val Leu Ser Asp Asp Met Lys Lys Leu Lys Ala 
1               5                   10                  15      


Arg Met Val Met Leu Leu Pro Thr Ser Ala Gln Gly Leu Gly Ala Trp 
            20                  25                  30          


Val Ser Ala Cys Asp Thr Glu Asp Thr Val Gly His Leu Gly Pro Trp 
        35                  40                  45              


Arg Asp Lys Asp Pro Ala Leu Trp Cys Gln Leu Cys Leu Ser Ser Gln 
    50                  55                  60                  


His Gln Ala Ile Glu Arg Phe Tyr Asp Lys Met Gln Asn Ala Glu Ser 
65                  70                  75                  80  


Gly Arg Gly Gln Val Met Ser Ser Leu Ala Glu Leu Glu Asp Asp Phe 
                85                  90                  95      


Lys Glu Gly Tyr Leu Glu Thr Val Ala Ala Tyr Tyr Glu Glu Gln His 
            100                 105                 110         


Pro Glu Leu Thr Pro Leu Leu Glu Lys Glu Arg Asp Gly Leu Arg Cys 
        115                 120                 125             


Arg Gly Asn Arg Ser Pro Val Pro Asp Val Glu Asp Pro Ala Thr Glu 
    130                 135                 140                 


Glu Pro Gly Glu Ser Phe Cys Asp Lys Val Met Arg Trp Phe Gln Ala 
145                 150                 155                 160 


Met Leu Gln Arg Leu Gln Thr Trp Trp His Gly Val Leu Ala Trp Val 
                165                 170                 175     


Lys Glu Lys Val Val Ala Leu Val His Ala Val Gln Ala Leu Trp Lys 
            180                 185                 190         


Gln Phe Gln Ser Phe Cys Cys Ser Leu Ser Glu Leu Phe Met Ser Ser 
        195                 200                 205             


Phe Gln Ser Tyr Gly Ala Pro Arg Gly Asp Lys Glu Glu Leu Thr Pro 
    210                 215                 220                 


Gln Lys Cys Ser Glu Pro Gln Ser Ser Lys 
225                 230                 


