                               SEQUENCE LISTING

<110> SALK INSTITUTE FOR BIOLOGICAL STUDIES
 
<120> COMPOSITIONS AND METHODS FOR ORGANOID GENERATION AND DISEASE 
      MODELING

<130> 167776.010901/PCT

<140> PCT/US2017/034278
<141> 2017-05-24

<150> 62/341,461
<151> 2016-05-25

<160> 52    

<170> PatentIn version 3.5

<210> 1
<211> 609
<212> PRT
<213> Homo sapiens

<400> 1
Met Lys Trp Val Glu Ser Ile Phe Leu Ile Phe Leu Leu Asn Phe Thr 
1               5                   10                  15      


Glu Ser Arg Thr Leu His Arg Asn Glu Tyr Gly Ile Ala Ser Ile Leu 
            20                  25                  30          


Asp Ser Tyr Gln Cys Thr Ala Glu Ile Ser Leu Ala Asp Leu Ala Thr 
        35                  40                  45              


Ile Phe Phe Ala Gln Phe Val Gln Glu Ala Thr Tyr Lys Glu Val Ser 
    50                  55                  60                  


Lys Met Val Lys Asp Ala Leu Thr Ala Ile Glu Lys Pro Thr Gly Asp 
65                  70                  75                  80  


Glu Gln Ser Ser Gly Cys Leu Glu Asn Gln Leu Pro Ala Phe Leu Glu 
                85                  90                  95      


Glu Leu Cys His Glu Lys Glu Ile Leu Glu Lys Tyr Gly His Ser Asp 
            100                 105                 110         


Cys Cys Ser Gln Ser Glu Glu Gly Arg His Asn Cys Phe Leu Ala His 
        115                 120                 125             


Lys Lys Pro Thr Pro Ala Ser Ile Pro Leu Phe Gln Val Pro Glu Pro 
    130                 135                 140                 


Val Thr Ser Cys Glu Ala Tyr Glu Glu Asp Arg Glu Thr Phe Met Asn 
145                 150                 155                 160 


Lys Phe Ile Tyr Glu Ile Ala Arg Arg His Pro Phe Leu Tyr Ala Pro 
                165                 170                 175     


Thr Ile Leu Leu Trp Ala Ala Arg Tyr Asp Lys Ile Ile Pro Ser Cys 
            180                 185                 190         


Cys Lys Ala Glu Asn Ala Val Glu Cys Phe Gln Thr Lys Ala Ala Thr 
        195                 200                 205             


Val Thr Lys Glu Leu Arg Glu Ser Ser Leu Leu Asn Gln His Ala Cys 
    210                 215                 220                 


Ala Val Met Lys Asn Phe Gly Thr Arg Thr Phe Gln Ala Ile Thr Val 
225                 230                 235                 240 


Thr Lys Leu Ser Gln Lys Phe Thr Lys Val Asn Phe Thr Glu Ile Gln 
                245                 250                 255     


Lys Leu Val Leu Asp Val Ala His Val His Glu His Cys Cys Arg Gly 
            260                 265                 270         


Asp Val Leu Asp Cys Leu Gln Asp Gly Glu Lys Ile Met Ser Tyr Ile 
        275                 280                 285             


Cys Ser Gln Gln Asp Thr Leu Ser Asn Lys Ile Thr Glu Cys Cys Lys 
    290                 295                 300                 


Leu Thr Thr Leu Glu Arg Gly Gln Cys Ile Ile His Ala Glu Asn Asp 
305                 310                 315                 320 


Glu Lys Pro Glu Gly Leu Ser Pro Asn Leu Asn Arg Phe Leu Gly Asp 
                325                 330                 335     


Arg Asp Phe Asn Gln Phe Ser Ser Gly Glu Lys Asn Ile Phe Leu Ala 
            340                 345                 350         


Ser Phe Val His Glu Tyr Ser Arg Arg His Pro Gln Leu Ala Val Ser 
        355                 360                 365             


Val Ile Leu Arg Val Ala Lys Gly Tyr Gln Glu Leu Leu Glu Lys Cys 
    370                 375                 380                 


Phe Gln Thr Glu Asn Pro Leu Glu Cys Gln Asp Lys Gly Glu Glu Glu 
385                 390                 395                 400 


Leu Gln Lys Tyr Ile Gln Glu Ser Gln Ala Leu Ala Lys Arg Ser Cys 
                405                 410                 415     


Gly Leu Phe Gln Lys Leu Gly Glu Tyr Tyr Leu Gln Asn Ala Phe Leu 
            420                 425                 430         


Val Ala Tyr Thr Lys Lys Ala Pro Gln Leu Thr Ser Ser Glu Leu Met 
        435                 440                 445             


Ala Ile Thr Arg Lys Met Ala Ala Thr Ala Ala Thr Cys Cys Gln Leu 
    450                 455                 460                 


Ser Glu Asp Lys Leu Leu Ala Cys Gly Glu Gly Ala Ala Asp Ile Ile 
465                 470                 475                 480 


Ile Gly His Leu Cys Ile Arg His Glu Met Thr Pro Val Asn Pro Gly 
                485                 490                 495     


Val Gly Gln Cys Cys Thr Ser Ser Tyr Ala Asn Arg Arg Pro Cys Phe 
            500                 505                 510         


Ser Ser Leu Val Val Asp Glu Thr Tyr Val Pro Pro Ala Phe Ser Asp 
        515                 520                 525             


Asp Lys Phe Ile Phe His Lys Asp Leu Cys Gln Ala Gln Gly Val Ala 
    530                 535                 540                 


Leu Gln Thr Met Lys Gln Glu Phe Leu Ile Asn Leu Val Lys Gln Lys 
545                 550                 555                 560 


Pro Gln Ile Thr Glu Glu Gln Leu Glu Ala Val Ile Ala Asp Phe Ser 
                565                 570                 575     


Gly Leu Leu Glu Lys Cys Cys Gln Gly Gln Glu Gln Glu Val Cys Phe 
            580                 585                 590         


Ala Glu Glu Gly Gln Lys Leu Ile Ser Lys Thr Arg Ala Ala Leu Gly 
        595                 600                 605             


Val 
    


<210> 2
<211> 2057
<212> DNA
<213> Homo sapiens

<400> 2
atattgtgct tccaccactg ccaataacaa aataactagc aaccatgaag tgggtggaat       60

caattttttt aattttccta ctaaatttta ctgaatccag aacactgcat agaaatgaat      120

atggaatagc ttccatattg gattcttacc aatgtactgc agagataagt ttagctgacc      180

tggctaccat attttttgcc cagtttgttc aagaagccac ttacaaggaa gtaagcaaaa      240

tggtgaaaga tgcattgact gcaattgaga aacccactgg agatgaacag tcttcagggt      300

gtttagaaaa ccagctacct gcctttctgg aagaactttg ccatgagaaa gaaattttgg      360

agaagtacgg acattcagac tgctgcagcc aaagtgaaga gggaagacat aactgttttc      420

ttgcacacaa aaagcccact ccagcatcga tcccactttt ccaagttcca gaacctgtca      480

caagctgtga agcatatgaa gaagacaggg agacattcat gaacaaattc atttatgaga      540

tagcaagaag gcatcccttc ctgtatgcac ctacaattct tctttgggct gctcgctatg      600

acaaaataat tccatcttgc tgcaaagctg aaaatgcagt tgaatgcttc caaacaaagg      660

cagcaacagt tacaaaagaa ttaagagaaa gcagcttgtt aaatcaacat gcatgtgcag      720

taatgaaaaa ttttgggacc cgaactttcc aagccataac tgttactaaa ctgagtcaga      780

agtttaccaa agttaatttt actgaaatcc agaaactagt cctggatgtg gcccatgtac      840

atgagcactg ttgcagagga gatgtgctgg attgtctgca ggatggggaa aaaatcatgt      900

cctacatatg ttctcaacaa gacactctgt caaacaaaat aacagaatgc tgcaaactga      960

ccacgctgga acgtggtcaa tgtataattc atgcagaaaa tgatgaaaaa cctgaaggtc     1020

tatctccaaa tctaaacagg tttttaggag atagagattt taaccaattt tcttcagggg     1080

aaaaaaatat cttcttggca agttttgttc atgaatattc aagaagacat cctcagcttg     1140

ctgtctcagt aattctaaga gttgctaaag gataccagga gttattggag aagtgtttcc     1200

agactgaaaa ccctcttgaa tgccaagata aaggagaaga agaattacag aaatacatcc     1260

aggagagcca agcattggca aagcgaagct gcggcctctt ccagaaacta ggagaatatt     1320

acttacaaaa tgcgtttctc gttgcttaca caaagaaagc cccccagctg acctcgtcgg     1380

agctgatggc catcaccaga aaaatggcag ccacagcagc cacttgttgc caactcagtg     1440

aggacaaact attggcctgt ggcgagggag cggctgacat tattatcgga cacttatgta     1500

tcagacatga aatgactcca gtaaaccctg gtgttggcca gtgctgcact tcttcatatg     1560

ccaacaggag gccatgcttc agcagcttgg tggtggatga aacatatgtc cctcctgcat     1620

tctctgatga caagttcatt ttccataagg atctgtgcca agctcagggt gtagcgctgc     1680

aaacgatgaa gcaagagttt ctcattaacc ttgtgaagca aaagccacaa ataacagagg     1740

aacaacttga ggctgtcatt gcagatttct caggcctgtt ggagaaatgc tgccaaggcc     1800

aggaacagga agtctgcttt gctgaagagg gacaaaaact gatttcaaaa actcgtgctg     1860

ctttgggagt ttaaattact tcaggggaag agaagacaaa acgagtcttt cattcggtgt     1920

gaacttttct ctttaatttt aactgattta acactttttg tgaattaatg aaatgataaa     1980

gacttttatg tgagatttcc ttatcacaga aataaaatat ctccaaatgt ttccttttca     2040

aaaaaaaaaa aaaaaaa                                                    2057


<210> 3
<211> 609
<212> PRT
<213> Homo sapiens

<400> 3
Met Lys Trp Val Thr Phe Ile Ser Leu Leu Phe Leu Phe Ser Ser Ala 
1               5                   10                  15      


Tyr Ser Arg Gly Val Phe Arg Arg Asp Ala His Lys Ser Glu Val Ala 
            20                  25                  30          


His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu Val Leu 
        35                  40                  45              


Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp His Val 
    50                  55                  60                  


Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val Ala Asp 
65                  70                  75                  80  


Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe Gly Asp 
                85                  90                  95      


Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu Met Ala 
            100                 105                 110         


Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe Leu Gln 
        115                 120                 125             


His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro Glu Val 
    130                 135                 140                 


Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe Leu Lys 
145                 150                 155                 160 


Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr Ala Pro 
                165                 170                 175     


Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr Glu Cys 
            180                 185                 190         


Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu Asp Glu 
        195                 200                 205             


Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu Lys Cys 
    210                 215                 220                 


Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp Ala Val 
225                 230                 235                 240 


Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu Val Ser 
                245                 250                 255     


Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys His Gly 
            260                 265                 270         


Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys Tyr Ile 
        275                 280                 285             


Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys Cys Glu 
    290                 295                 300                 


Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu Asn Asp 
305                 310                 315                 320 


Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val Glu Ser 
                325                 330                 335     


Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe Leu Gly 
            340                 345                 350         


Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser Val Val 
        355                 360                 365             


Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu Lys Cys 
    370                 375                 380                 


Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe Asp Glu 
385                 390                 395                 400 


Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln Asn Cys 
                405                 410                 415     


Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala Leu Leu 
            420                 425                 430         


Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr Leu Val 
        435                 440                 445             


Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys Lys His 
    450                 455                 460                 


Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser Val Val 
465                 470                 475                 480 


Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser Asp Arg 
                485                 490                 495     


Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro Cys Phe 
            500                 505                 510         


Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe Asn Ala 
        515                 520                 525             


Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu Lys Glu 
    530                 535                 540                 


Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys His Lys 
545                 550                 555                 560 


Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp Phe Ala 
                565                 570                 575     


Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr Cys Phe 
            580                 585                 590         


Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala Leu Gly 
        595                 600                 605             


Leu 
    


<210> 4
<211> 2264
<212> DNA
<213> Homo sapiens

<400> 4
agtatattag tgctaatttc cctccgtttg tcctagcttt tctcttctgt caaccccaca       60

cgcctttggc acaatgaagt gggtaacctt tatttccctt ctttttctct ttagctcggc      120

ttattccagg ggtgtgtttc gtcgagatgc acacaagagt gaggttgctc atcggtttaa      180

agatttggga gaagaaaatt tcaaagcctt ggtgttgatt gcctttgctc agtatcttca      240

gcagtgtcca tttgaagatc atgtaaaatt agtgaatgaa gtaactgaat ttgcaaaaac      300

atgtgttgct gatgagtcag ctgaaaattg tgacaaatca cttcataccc tttttggaga      360

caaattatgc acagttgcaa ctcttcgtga aacctatggt gaaatggctg actgctgtgc      420

aaaacaagaa cctgagagaa atgaatgctt cttgcaacac aaagatgaca acccaaacct      480

cccccgattg gtgagaccag aggttgatgt gatgtgcact gcttttcatg acaatgaaga      540

gacatttttg aaaaaatact tatatgaaat tgccagaaga catccttact tttatgcccc      600

ggaactcctt ttctttgcta aaaggtataa agctgctttt acagaatgtt gccaagctgc      660

tgataaagct gcctgcctgt tgccaaagct cgatgaactt cgggatgaag ggaaggcttc      720

gtctgccaaa cagagactca agtgtgccag tctccaaaaa tttggagaaa gagctttcaa      780

agcatgggca gtagctcgcc tgagccagag atttcccaaa gctgagtttg cagaagtttc      840

caagttagtg acagatctta ccaaagtcca cacggaatgc tgccatggag atctgcttga      900

atgtgctgat gacagggcgg accttgccaa gtatatctgt gaaaatcaag attcgatctc      960

cagtaaactg aaggaatgct gtgaaaaacc tctgttggaa aaatcccact gcattgccga     1020

agtggaaaat gatgagatgc ctgctgactt gccttcatta gctgctgatt ttgttgaaag     1080

taaggatgtt tgcaaaaact atgctgaggc aaaggatgtc ttcctgggca tgtttttgta     1140

tgaatatgca agaaggcatc ctgattactc tgtcgtgctg ctgctgagac ttgccaagac     1200

atatgaaacc actctagaga agtgctgtgc cgctgcagat cctcatgaat gctatgccaa     1260

agtgttcgat gaatttaaac ctcttgtgga agagcctcag aatttaatca aacaaaattg     1320

tgagcttttt gagcagcttg gagagtacaa attccagaat gcgctattag ttcgttacac     1380

caagaaagta ccccaagtgt caactccaac tcttgtagag gtctcaagaa acctaggaaa     1440

agtgggcagc aaatgttgta aacatcctga agcaaaaaga atgccctgtg cagaagacta     1500

tctatccgtg gtcctgaacc agttatgtgt gttgcatgag aaaacgccag taagtgacag     1560

agtcaccaaa tgctgcacag aatccttggt gaacaggcga ccatgctttt cagctctgga     1620

agtcgatgaa acatacgttc ccaaagagtt taatgctgaa acattcacct tccatgcaga     1680

tatatgcaca ctttctgaga aggagagaca aatcaagaaa caaactgcac ttgttgagct     1740

cgtgaaacac aagcccaagg caacaaaaga gcaactgaaa gctgttatgg atgatttcgc     1800

agcttttgta gagaagtgct gcaaggctga cgataaggag acctgctttg ccgaggaggg     1860

taaaaaactt gttgctgcaa gtcaagctgc cttaggctta taacatcaca tttaaaagca     1920

tctcagccta ccatgagaat aagagaaaga aaatgaagat caaaagctta ttcatctgtt     1980

tttctttttc gttggtgtaa agccaacacc ctgtctaaaa aacataaatt tctttaatca     2040

ttttgcctct tttctctgtg cttcaattaa taaaaaatgg aaagaatcta atagagtggt     2100

acagcactgt tatttttcaa agatgtgttg ctatcctgaa aattctgtag gttctgtgga     2160

agttccagtg ttctctctta ttccacttcg gtagaggatt tctagtttct tgtgggctaa     2220

ttaaataaat cattaatact cttctaaaaa aaaaaaaaaa aaaa                      2264


<210> 5
<211> 313
<212> PRT
<213> Homo sapiens

<400> 5
Met Tyr Val Ser Tyr Leu Leu Asp Lys Asp Val Ser Met Tyr Pro Ser 
1               5                   10                  15      


Ser Val Arg His Ser Gly Gly Leu Asn Leu Ala Pro Gln Asn Phe Val 
            20                  25                  30          


Ser Pro Pro Gln Tyr Pro Asp Tyr Gly Gly Tyr His Val Ala Ala Ala 
        35                  40                  45              


Ala Ala Ala Ala Ala Asn Leu Asp Ser Ala Gln Ser Pro Gly Pro Ser 
    50                  55                  60                  


Trp Pro Ala Ala Tyr Gly Ala Pro Leu Arg Glu Asp Trp Asn Gly Tyr 
65                  70                  75                  80  


Ala Pro Gly Gly Ala Ala Ala Ala Ala Asn Ala Val Ala His Gly Leu 
                85                  90                  95      


Asn Gly Gly Ser Pro Ala Ala Ala Met Gly Tyr Ser Ser Pro Ala Asp 
            100                 105                 110         


Tyr His Pro His His His Pro His His His Pro His His Pro Ala Ala 
        115                 120                 125             


Ala Pro Ser Cys Ala Ser Gly Leu Leu Gln Thr Leu Asn Pro Gly Pro 
    130                 135                 140                 


Pro Gly Pro Ala Ala Thr Ala Ala Ala Glu Gln Leu Ser Pro Gly Gly 
145                 150                 155                 160 


Gln Arg Arg Asn Leu Cys Glu Trp Met Arg Lys Pro Ala Gln Gln Ser 
                165                 170                 175     


Leu Gly Ser Gln Val Lys Thr Arg Thr Lys Asp Lys Tyr Arg Val Val 
            180                 185                 190         


Tyr Thr Asp His Gln Arg Leu Glu Leu Glu Lys Glu Phe His Tyr Ser 
        195                 200                 205             


Arg Tyr Ile Thr Ile Arg Arg Lys Ala Glu Leu Ala Ala Thr Leu Gly 
    210                 215                 220                 


Leu Ser Glu Arg Gln Val Lys Ile Trp Phe Gln Asn Arg Arg Ala Lys 
225                 230                 235                 240 


Glu Arg Lys Ile Asn Lys Lys Lys Leu Gln Gln Gln Gln Gln Gln Gln 
                245                 250                 255     


Pro Pro Gln Pro Pro Pro Pro Pro Pro Gln Pro Pro Gln Pro Gln Pro 
            260                 265                 270         


Gly Pro Leu Arg Ser Val Pro Glu Pro Leu Ser Pro Val Ser Ser Leu 
        275                 280                 285             


Gln Ala Ser Val Ser Gly Ser Val Pro Gly Val Leu Gly Pro Thr Gly 
    290                 295                 300                 


Gly Val Leu Asn Pro Thr Val Thr Gln 
305                 310             


<210> 6
<211> 2370
<212> DNA
<213> Homo sapiens

<400> 6
ctccaaccat tggtgtctgt gtcattacta atagagtctt gtaaacactc gttaatcacg       60

gaaggccgcc ggcctggggc tccgcacgcc agcctgtggc gggtcttccc cgcctctgca      120

gcctagtggg aaggaggtgg gaggaaagaa ggaagaaagg gagggaggga ggaggcaggc      180

cagagggagg gaccgcctcg gaggcagaag agccgcgagg agccagcgga gcaccgcggg      240

ctggggcgca gccacccgcc gctcctcgag tcccctcgcc cctttccctt cgtgcccccc      300

ggcagcctcc agcgtcggtc cccaggcagc atggtgaggt ctgctcccgg accctcgcca      360

ccatgtacgt gagctacctc ctggacaagg acgtgagcat gtaccctagc tccgtgcgcc      420

actctggcgg cctcaacctg gcgccgcaga acttcgtcag ccccccgcag tacccggact      480

acggcggtta ccacgtggcg gccgcagctg cagcggcagc gaacttggac agcgcgcagt      540

ccccggggcc atcctggccg gcagcgtatg gcgccccact ccgggaggac tggaatggct      600

acgcgcccgg aggcgccgcg gccgccgcca acgccgtggc tcacggcctc aacggtggct      660

ccccggccgc agccatgggc tacagcagcc ccgcagacta ccatccgcac caccacccgc      720

atcaccaccc gcaccacccg gccgccgcgc cttcctgcgc ttctgggctg ctgcaaacgc      780

tcaaccccgg ccctcctggg cccgccgcca ccgctgccgc cgagcagctg tctcccggcg      840

gccagcggcg gaacctgtgc gagtggatgc ggaagccggc gcagcagtcc ctcggcagcc      900

aagtgaaaac caggacgaaa gacaaatatc gagtggtgta cacggaccac cagcggctgg      960

agctggagaa ggagtttcac tacagtcgct acatcaccat ccggaggaaa gccgagctag     1020

ccgccacgct ggggctctct gagaggcagg ttaaaatctg gtttcagaac cgcagagcaa     1080

aggagaggaa aatcaacaag aagaagttgc agcagcaaca gcagcagcag ccaccacagc     1140

cgcctccgcc gccaccacag cctccccagc ctcagccagg tcctctgaga agtgtcccag     1200

agcccttgag tccggtgtct tccctgcaag cctcagtgtc tggctctgtc cctggggttc     1260

tggggccaac tgggggggtg ctaaacccca ccgtcaccca gtgacccacc gggttctgca     1320

gcggcagagc aattccaggc tgagccatga ggagcgtgga ctctgctaga ctcctcagga     1380

gagacccctc ccctcccacc cacagccata gacctacaga cctggctctc agaggaaaaa     1440

tgggagccag gagtaagaca agtgggattt ggggcctcaa gaaatatact ctcccagatt     1500

tttacttttt cccatctggc tttttctgcc actgaggaga cagaaagcct ccgctgggct     1560

tcattccgga ctggcagaag cattgcctgg actgaccaca ccaaccaggc cttcatcctc     1620

ctccccagct cttctcttcc tagatctgca ggctgcacct ctggctagag ccgaggggag     1680

agagggactc aagggaaagg caagcttgag gccaagatgg ctgctgcctg ctcatggccc     1740

tcggaggtcc agctgggcct cctgcctccg ggcaggcaag gtttacactg cggaagccaa     1800

aggcagctaa gatagaaagc tggactgacc aaagactgca gaacccccag gtggcctgcg     1860

tcttttttct cttcccttcc cagaccagga aaggcttggc tggtgtatgc acagggtgtg     1920

gtatgagggg gtggttattg gactccaggc ctgaccaggg ggcccgaaca gggacttgtt     1980

tagagagcct gtcaccagag cttctctggg ctgaatgtat gtcagtgcta taaatgccag     2040

agccaacctg gacttcctgt cattttcaca atcttggggc tgatgaagaa gggggtgggg     2100

ggagtttgtg ttgttgttgc tgctgtttgg gttgttggtc tgtgtaacat ccaagccaga     2160

gtttttaaag ccttctggat ccatgggggg agaagtgata tggtgaaggg aagtggggag     2220

tatttgaaca cagttgaatt ttttctaaaa agaaaaagag ataaatgagc tttccagatt     2280

tcagattctg tatttatctt cagattttgt ctgcaactat tttttatttt ttaaagaaat     2340

gaaatatctt caaaaaaaaa aaaaaaaaaa                                      2370


<210> 7
<211> 503
<212> PRT
<213> Homo sapiens

<400> 7
Met Asp Leu Ile Pro Asn Leu Ala Val Glu Thr Trp Leu Leu Leu Ala 
1               5                   10                  15      


Val Ser Leu Ile Leu Leu Tyr Leu Tyr Gly Thr Arg Thr His Gly Leu 
            20                  25                  30          


Phe Lys Lys Leu Gly Ile Pro Gly Pro Thr Pro Leu Pro Phe Leu Gly 
        35                  40                  45              


Asn Ala Leu Ser Phe Arg Lys Gly Tyr Trp Thr Phe Asp Met Glu Cys 
    50                  55                  60                  


Tyr Lys Lys Tyr Arg Lys Val Trp Gly Ile Tyr Asp Cys Gln Gln Pro 
65                  70                  75                  80  


Met Leu Ala Ile Thr Asp Pro Asp Met Ile Lys Thr Val Leu Val Lys 
                85                  90                  95      


Glu Cys Tyr Ser Val Phe Thr Asn Arg Arg Pro Phe Gly Pro Val Gly 
            100                 105                 110         


Phe Met Lys Asn Ala Ile Ser Ile Ala Glu Asp Glu Glu Trp Lys Arg 
        115                 120                 125             


Ile Arg Ser Leu Leu Ser Pro Thr Phe Thr Ser Gly Lys Leu Lys Glu 
    130                 135                 140                 


Met Val Pro Ile Ile Ala Gln Tyr Gly Asp Val Leu Val Arg Asn Leu 
145                 150                 155                 160 


Arg Arg Glu Ala Glu Thr Gly Lys Pro Val Thr Leu Lys His Val Phe 
                165                 170                 175     


Gly Ala Tyr Ser Met Asp Val Ile Thr Ser Thr Ser Phe Gly Val Ser 
            180                 185                 190         


Ile Asp Ser Leu Asn Asn Pro Gln Asp Pro Phe Val Glu Asn Thr Lys 
        195                 200                 205             


Lys Leu Leu Arg Phe Asn Pro Leu Asp Pro Phe Val Leu Ser Ile Lys 
    210                 215                 220                 


Val Phe Pro Phe Leu Thr Pro Ile Leu Glu Ala Leu Asn Ile Thr Val 
225                 230                 235                 240 


Phe Pro Arg Lys Val Ile Ser Phe Leu Thr Lys Ser Val Lys Gln Ile 
                245                 250                 255     


Lys Glu Gly Arg Leu Lys Glu Thr Gln Lys His Arg Val Asp Phe Leu 
            260                 265                 270         


Gln Leu Met Ile Asp Ser Gln Asn Ser Lys Asp Ser Glu Thr His Lys 
        275                 280                 285             


Ala Leu Ser Asp Leu Glu Leu Met Ala Gln Ser Ile Ile Phe Ile Phe 
    290                 295                 300                 


Ala Gly Tyr Glu Thr Thr Ser Ser Val Leu Ser Phe Ile Ile Tyr Glu 
305                 310                 315                 320 


Leu Ala Thr His Pro Asp Val Gln Gln Lys Val Gln Lys Glu Ile Asp 
                325                 330                 335     


Thr Val Leu Pro Asn Lys Ala Pro Pro Thr Tyr Asp Thr Val Leu Gln 
            340                 345                 350         


Leu Glu Tyr Leu Asp Met Val Val Asn Glu Thr Leu Arg Leu Phe Pro 
        355                 360                 365             


Val Ala Met Arg Leu Glu Arg Val Cys Lys Lys Asp Val Glu Ile Asn 
    370                 375                 380                 


Gly Met Phe Ile Pro Lys Gly Val Val Val Met Ile Pro Ser Tyr Val 
385                 390                 395                 400 


Leu His His Asp Pro Lys Tyr Trp Thr Glu Pro Glu Lys Phe Leu Pro 
                405                 410                 415     


Glu Arg Phe Ser Lys Lys Asn Lys Asp Asn Ile Asp Pro Tyr Ile Tyr 
            420                 425                 430         


Thr Pro Phe Gly Ser Gly Pro Arg Asn Cys Ile Gly Met Arg Phe Ala 
        435                 440                 445             


Leu Val Asn Met Lys Leu Ala Leu Val Arg Val Leu Gln Asn Phe Ser 
    450                 455                 460                 


Phe Lys Pro Cys Lys Glu Thr Gln Ile Pro Leu Lys Leu Arg Phe Gly 
465                 470                 475                 480 


Gly Leu Leu Leu Thr Glu Lys Pro Ile Val Leu Lys Ala Glu Ser Arg 
                485                 490                 495     


Asp Glu Thr Val Ser Gly Ala 
            500             


<210> 8
<211> 2099
<212> DNA
<213> Homo sapiens

<400> 8
aatcactgct gtgcagggca ggaaagctcc acacacacag cccagcaaac agcagcacgc       60

tgctgaaaaa aagactcaga ggagagagat aaggaaggaa agtagtgatg gatctcatcc      120

caaacttggc cgtggaaacc tggcttctcc tggctgtcag cctgatactc ctctatctat      180

atggaacccg tacacatgga ctttttaaga agcttggaat tccagggccc acacctctgc      240

cttttttggg aaatgctttg tccttccgta agggctattg gacgtttgac atggaatgtt      300

ataaaaagta tagaaaagtc tggggtattt atgactgtca acagcctatg ctggctatca      360

cagatcccga catgatcaaa acagtgctag tgaaagaatg ttattctgtc ttcacaaacc      420

ggaggccttt cgggccagtg ggatttatga aaaatgccat ctctatagct gaggatgaag      480

aatggaagag aatacgatca ttgctgtctc caacattcac cagcggaaaa ctcaaggaga      540

tggtccctat cattgcccag tatggagatg tgttggtgag aaatctgagg cgggaagcag      600

agacaggcaa gcctgtcacc ttgaaacacg tctttggggc ctacagcatg gatgtgatca      660

ctagcacatc atttggagtg agcatcgact ctctcaacaa tccacaagac ccctttgtgg      720

aaaacaccaa gaagctttta agatttaatc cattagatcc attcgttctc tcaataaaag      780

tctttccatt ccttacccca attcttgaag cattaaatat cactgtgttt ccaagaaaag      840

ttataagttt tctaacaaaa tctgtaaaac agataaaaga aggtcgcctc aaagagacac      900

aaaagcaccg agtggatttc cttcagctga tgattgactc tcagaattca aaagactctg      960

agacccacaa agctctgtct gatctggagc tcatggccca atcaattatc tttatttttg     1020

ctggctatga aaccacgagc agtgttctct ccttcattat atatgaactg gccactcacc     1080

ctgatgtcca gcagaaagtg cagaaggaaa ttgatacagt tttacccaat aaggcaccac     1140

ccacctatga tactgtgcta cagttggagt atcttgacat ggtggtgaat gaaacactca     1200

gattattccc agttgctatg agacttgaga gggtctgcaa aaaagatgtt gaaatcaatg     1260

ggatgtttat tcccaaaggg gtggtggtga tgattccaag ctatgttctt catcatgacc     1320

caaagtactg gacagagcct gagaagttcc tccctgaaag gttcagtaaa aagaacaagg     1380

acaacataga tccttacata tacacaccct ttggaagtgg acccagaaac tgcattggca     1440

tgaggtttgc tctcgtgaac atgaaacttg ctctagtcag agtccttcag aacttctcct     1500

tcaaaccttg taaagaaaca cagatccccc tgaaattacg ctttggagga cttcttctaa     1560

cagaaaaacc cattgttcta aaggctgagt caagggatga gaccgtaagt ggagcctgat     1620

ttccctaagg acttctggtt tgctctttaa gaaagctgtg ccccagaaca ccagagacct     1680

caaattactt tacaaataga accctgaaat gaagacgggc ttcatccaat gtgctgcata     1740

aataatcagg gattctgtac gtgcattgtg ctctctcatg gtctgtatag agtgttatac     1800

ttggtaatat agaggagatg accaaatcag tgctggggaa gtagatttgg cttctctgct     1860

tctcatagga ctatctccac cacccccagt tagcaccatt aactcctcct gagctctgat     1920

aacataatta acatttctca ataatttcaa ccacaatcat taataaaaat aggaattatt     1980

ttgatggctc taacagtgac atttatatca tgtgttatat ctgtagtatt ctatagtaag     2040

ctttatatta agcaaatcaa taaaaacctc tttacaaaag taaaaaaaaa aaaaaaaaa      2099


<210> 9
<211> 435
<212> PRT
<213> Homo sapiens

<400> 9
Met Ser Asn Lys Asp Arg His Ile Asp Ser Ser Cys Ser Ser Phe Ile 
1               5                   10                  15      


Lys Thr Glu Pro Ser Ser Pro Ala Ser Leu Thr Asp Ser Val Asn His 
            20                  25                  30          


His Ser Pro Gly Gly Ser Ser Asp Ala Ser Gly Ser Tyr Ser Ser Thr 
        35                  40                  45              


Met Asn Gly His Gln Asn Gly Leu Asp Ser Pro Pro Leu Tyr Pro Ser 
    50                  55                  60                  


Ala Pro Ile Leu Gly Gly Ser Gly Pro Val Arg Lys Leu Tyr Asp Asp 
65                  70                  75                  80  


Cys Ser Ser Thr Ile Val Glu Asp Pro Gln Thr Lys Cys Glu Tyr Met 
                85                  90                  95      


Leu Asn Ser Met Pro Lys Arg Leu Cys Leu Val Cys Gly Asp Ile Ala 
            100                 105                 110         


Ser Gly Tyr His Tyr Gly Val Ala Ser Cys Glu Ala Cys Lys Ala Phe 
        115                 120                 125             


Phe Lys Arg Thr Ile Gln Gly Asn Ile Glu Tyr Ser Cys Pro Ala Thr 
    130                 135                 140                 


Asn Glu Cys Glu Ile Thr Lys Arg Arg Arg Lys Ser Cys Gln Ala Cys 
145                 150                 155                 160 


Arg Phe Met Lys Cys Leu Lys Val Gly Met Leu Lys Glu Gly Val Arg 
                165                 170                 175     


Leu Asp Arg Val Arg Gly Gly Arg Gln Lys Tyr Lys Arg Arg Ile Asp 
            180                 185                 190         


Ala Glu Asn Ser Pro Tyr Leu Asn Pro Gln Leu Val Gln Pro Ala Lys 
        195                 200                 205             


Lys Pro Tyr Asn Lys Ile Val Ser His Leu Leu Val Ala Glu Pro Glu 
    210                 215                 220                 


Lys Ile Tyr Ala Met Pro Asp Pro Thr Val Pro Asp Ser Asp Ile Lys 
225                 230                 235                 240 


Ala Leu Thr Thr Leu Cys Asp Leu Ala Asp Arg Glu Leu Val Val Ile 
                245                 250                 255     


Ile Gly Trp Ala Lys His Ile Pro Gly Phe Ser Thr Leu Ser Leu Ala 
            260                 265                 270         


Asp Gln Met Ser Leu Leu Gln Ser Ala Trp Met Glu Ile Leu Ile Leu 
        275                 280                 285             


Gly Val Val Tyr Arg Ser Leu Ser Phe Glu Asp Glu Leu Val Tyr Ala 
    290                 295                 300                 


Asp Asp Tyr Ile Met Asp Glu Asp Gln Ser Lys Leu Ala Gly Leu Leu 
305                 310                 315                 320 


Asp Leu Asn Asn Ala Ile Leu Gln Leu Val Lys Lys Tyr Lys Ser Met 
                325                 330                 335     


Lys Leu Glu Lys Glu Glu Phe Val Thr Leu Lys Ala Ile Ala Leu Ala 
            340                 345                 350         


Asn Ser Asp Ser Met His Ile Glu Asp Val Glu Ala Val Gln Lys Leu 
        355                 360                 365             


Gln Asp Val Leu His Glu Ala Leu Gln Asp Tyr Glu Ala Gly Gln His 
    370                 375                 380                 


Met Glu Asp Pro Arg Arg Ala Gly Lys Met Leu Met Thr Leu Pro Leu 
385                 390                 395                 400 


Leu Arg Gln Thr Ser Thr Lys Ala Val Gln His Phe Tyr Asn Ile Lys 
                405                 410                 415     


Leu Glu Gly Lys Val Pro Met His Lys Leu Phe Leu Glu Met Leu Glu 
            420                 425                 430         


Ala Lys Val 
        435 


<210> 10
<211> 5559
<212> DNA
<213> Homo sapiens

<400> 10
aagctccaat cggggcttta agtccttgat taggagagtg tgagagcttt ggtcccaact       60

ggctgtgcct ataggcttgt cactaggaga acatttgtgt taattgcact gtgctctgtc      120

aaggaaactt tgatttatag ctggggtgca caaataatgg ttgccggtcg cacatggatt      180

cggtagaact ttgccttcct gaatcttttt ccctgcacta cgaggaagag tagacttgaa      240

tgagacctgc ctcatcagtc atgggatcat agtgtcacag atggaaaagc aactatcagc      300

tgaattgtac tgaactacac acttggctaa ttcatcttat tgctctacac atctaaagga      360

aggctcattc tgttcttgga gtctagacag catcaggagt tgggctcagt gaacaaaact      420

ttaatgtcta gagcatttat gagggtttta atgattggaa aatctatcct gagaatgtgg      480

tcaccatatg tgacagcctt gctttctatc ttgtcttcag tttctggggc ttctctgcag      540

aatgtcaaac aaagatcgac acattgattc cagctgttcg tccttcatca agacggaacc      600

ttccagccca gcctccctga cggacagcgt caaccaccac agccctggtg gctcttcaga      660

cgccagtggg agctacagtt caaccatgaa tggccatcag aacggacttg actcgccacc      720

tctctaccct tctgctccta tcctgggagg tagtgggcct gtcaggaaac tgtatgatga      780

ctgctccagc accattgttg aagatcccca gaccaagtgt gaatacatgc tcaactcgat      840

gcccaagaga ctgtgtttag tgtgtggtga catcgcttct gggtaccact atggggtagc      900

atcatgtgaa gcctgcaagg cattcttcaa gaggacaatt caaggcaata tagaatacag      960

ctgccctgcc acgaatgaat gtgaaatcac aaagcgcaga cgtaaatcct gccaggcttg     1020

ccgcttcatg aagtgtttaa aagtgggcat gctgaaagaa ggggtgcgtc ttgacagagt     1080

acgtggaggt cggcagaagt acaagcgcag gatagatgcg gagaacagcc catacctgaa     1140

ccctcagctg gttcagccag ccaaaaagcc atataacaag attgtctcac atttgttggt     1200

ggctgaaccg gagaagatct atgccatgcc tgaccctact gtccccgaca gtgacatcaa     1260

agccctcact acactgtgtg acttggccga ccgagagttg gtggttatca ttggatgggc     1320

gaagcatatt ccaggcttct ccacgctgtc cctggcggac cagatgagcc ttctgcagag     1380

tgcttggatg gaaattttga tccttggtgt cgtataccgg tctctttcgt ttgaggatga     1440

acttgtctat gcagacgatt atataatgga cgaagaccag tccaaattag caggccttct     1500

tgatctaaat aatgctatcc tgcagctggt aaagaaatac aagagcatga agctggaaaa     1560

agaagaattt gtcaccctca aagctatagc tcttgctaat tcagactcca tgcacataga     1620

agatgttgaa gccgttcaga agcttcagga tgtcttacat gaagcgctgc aggattatga     1680

agctggccag cacatggaag accctcgtcg agctggcaag atgctgatga cactgccact     1740

cctgaggcag acctctacca aggccgtgca gcatttctac aacatcaaac tagaaggcaa     1800

agtcccaatg cacaaacttt ttttggaaat gttggaggcc aaggtctgac taaaagctcc     1860

ctgggccttc ccatccttca tgttgaaaaa gggaaaataa acccaagagt gatgtcgaag     1920

aaacttagag tttagttaac aacatcaaaa atcaacagac tgcactgata atttagcagc     1980

aagactatga agcagctttc agattcctcc ataggttcct gatgagtttc tttctacttt     2040

ctccatcatc ttctttcctc tttcttccca catttctctt tctctttatt ttttctcctt     2100

ttcttctttc acctccctta tttctttgct tctttcattc ctagttccca ttctccttta     2160

ttttcttccc gtctgcctgc cttctttctt ttctttacct actctcattc ctctcttttc     2220

tcatccttcc ccttttttct aaatttgaaa tagctttagt ttaaaaaaaa atcctccctt     2280

ccccctttcc tttccctttc tttccttttt ccctttcctt ttccctttcc tttcctttcc     2340

tcttgacctt ctttccatct ttctttttct tccttctgct gctgaacttt taaaagaggt     2400

ctctaactga agagagatgg aagccagccc tgccaaagga tggagatcca taatatggat     2460

gccagtgaac ttattgtgaa ccatactgtc cccaatgact aaggaatcaa agagagagaa     2520

ccaacgttcc taaaagtaca gtgcaacata tacaaattga ctgagtgcag tattagattt     2580

catgggagca gcctctaatt agacaactta agcaacgttg catcggctgc ttcttatcat     2640

tgcttttcca tctagatcag ttacagccat ttgattcctt aattgttttt tcaagtcttc     2700

caggtatttg ttagtttagc tactatgtaa ctttttcagg gaatagttta agctttattc     2760

attcatgcaa tactaaagag aaataagaat actgcaattt tgtgctggct ttgaacaatt     2820

acgaacaata atgaaggaca aatgaatcct gaaggaagat ttttaaaaat gttttgtttc     2880

ttcttacaaa tggagatttt tttgtaccag ctttaccact tttcagccat ttattaatat     2940

gggaatttaa cttactcaag caatagttga agggaaggtg catattatca cggatgcaat     3000

ttatgttgtg tgccagtctg gtcccaaaca tcaatttctt aacatgagct ccagtttacc     3060

taaatgttca ctgacacaaa ggatgagatt acacctacag tgactctgag tagtcacata     3120

tataagcact gcacatgaga tatagatccg tagaattgtc aggagtgcac ctctctactt     3180

gggaggtaca attgccatat gatttctagc tgccatggtg gttaggaatg tgatactgcc     3240

tgtttgcaaa gtcacagacc ttgcctcaga aggagctgtg agccagtatt catttaagag     3300

gcaataaggc aaatgccaga attaaaaaaa aaaatcatca aagacagaaa atgcctgacc     3360

aaattctaaa acctaatcca tataagttta ttcatttagg aatgttcgtt taaattaatc     3420

tgcagttttt accaagagct aagccaatat atgtgctttt caaccagtat tgtcacagca     3480

tgaaagtcaa gtcaggttcc agactgttaa gaggtgtaat ctaatgaaga aatcaattag     3540

atgccccgaa atctacagtc gctgaataac caataaacag taacctccat caaatgctat     3600

accaatggac cagtgttagt agctgctccc tgtattatgt gaacagtctt attctatgta     3660

cacagatgta attaaaattg taatcctaac aaacaaaaga aatgtagttc agcttttcaa     3720

tgtttcatgt ttgctgtgct tttctgaatt ttatgttgca ttcaaagact gttgtcttgt     3780

tcttgtggtg tttggattct tgtggtgtgt gcttttagac acagggtaga attagagaca     3840

atattggatg tacaattcct caggagacta cagtagtata ttctattcct taccagtaat     3900

aaggttcttc ctaataataa ttaagagatt gaaactccaa acaagtattc attatgaaca     3960

gatacacatc aaaatcataa taatattttc aaaacaagga ataatttctc taatggttta     4020

ttatagaata ccaatgtata gcttagaaat aaaactttga atatttcaag aatatagata     4080

agtctaattt ttaaatgctg tatatatggc tttcactcaa tcatctctca gatgttgtta     4140

ttaactcgct ctgtgttgtt gcaaaacttt ttggtgcaga ttcgtttcca aaactattgc     4200

tactttgtgt gctttaaaca aaataccttg ggttgatgaa acatcaaccc agtgctagga     4260

atactgtgta tctatcatta gctatatggg actatattgt agattgtggt ttctcagtag     4320

agaagtgact gtagtgtgat tctagataaa tcatcattag caattcattc agatggtcaa     4380

taacttgaaa tttatagctg tgataggagt tcagaaattg gcacatccct ttaaaaataa     4440

caacagaaaa tacaactcct gggaaaaaag gtgctgattc tataagatta tttatatatg     4500

taagtgttta aaaagattat tttccagaaa gtttgtgcag ggtttaagtt gctactattc     4560

aactacacta tatataaata aaatatatac aatatataca ttgttttcac tgtatcacat     4620

taaagtactt gggcttcaga agtaagagcc aaccaactga aaacctgaga tggagatatg     4680

ttcaaagaat gagatacaat tttttagttt tcagtttaag taactctcag cattacaaaa     4740

gagtaagtat ctcacaaata ggaaataaaa ctaaaacgtg gatttaaaaa gaactgcacg     4800

ggctttaggg taaatgctca tcttaaacct cactagaggg aagtcttctc aagtttcaag     4860

caagaccatt tacttaatgt gaagttttgg aaagttataa aggtgtatgt tttagccata     4920

tgattttaat tttaattttg cttcttttag gttcgttctt atttaaagca atatgattgt     4980

gtgactcctt gtagttacac ttgtgtttca atcagatcag attgttgtat ttattccact     5040

attttgcatt taaatgataa cataaaagat ataaaaaatt taaaactgct atttttctta     5100

tagaagagaa aatgggtgtt ggtgattgta ttttaattat ttaagcgtct ctgtttacct     5160

gcctaggaaa acattttatg gcagtcttat gtgcaaagat cgtaaaagga caaaaaattt     5220

aaactgctta taataatcca ggagttgcat tatagccagt agtaaaaata ataataataa     5280

taataaaacc atgtctatag ctgtagatgg gcttcacatc tgtaaagcaa tcaattgtat     5340

atttttgtga tgtgtaccat actgtgtgct ccagcaaatg tccatttgtg taaatgtatt     5400

tattttatat tgtatatatt gttaaatgca aaaaggagat atgattctgt aactccaatc     5460

agttcagatg tgtaactcaa attattatgc ctttcaggat gatggtagag caatattaaa     5520

caagcttcca cttttgactg ctaaaaaaaa aaaaaaaaa                            5559


<210> 11
<211> 463
<212> PRT
<213> Homo sapiens

<400> 11
Met His Ser Ala Ser Ser Met Leu Gly Ala Val Lys Met Glu Gly His 
1               5                   10                  15      


Glu Pro Ser Asp Trp Ser Ser Tyr Tyr Ala Glu Pro Glu Gly Tyr Ser 
            20                  25                  30          


Ser Val Ser Asn Met Asn Ala Gly Leu Gly Met Asn Gly Met Asn Thr 
        35                  40                  45              


Tyr Met Ser Met Ser Ala Ala Ala Met Gly Ser Gly Ser Gly Asn Met 
    50                  55                  60                  


Ser Ala Gly Ser Met Asn Met Ser Ser Tyr Val Gly Ala Gly Met Ser 
65                  70                  75                  80  


Pro Ser Leu Ala Gly Met Ser Pro Gly Ala Gly Ala Met Ala Gly Met 
                85                  90                  95      


Gly Gly Ser Ala Gly Ala Ala Gly Val Ala Gly Met Gly Pro His Leu 
            100                 105                 110         


Ser Pro Ser Leu Ser Pro Leu Gly Gly Gln Ala Ala Gly Ala Met Gly 
        115                 120                 125             


Gly Leu Ala Pro Tyr Ala Asn Met Asn Ser Met Ser Pro Met Tyr Gly 
    130                 135                 140                 


Gln Ala Gly Leu Ser Arg Ala Arg Asp Pro Lys Thr Tyr Arg Arg Ser 
145                 150                 155                 160 


Tyr Thr His Ala Lys Pro Pro Tyr Ser Tyr Ile Ser Leu Ile Thr Met 
                165                 170                 175     


Ala Ile Gln Gln Ser Pro Asn Lys Met Leu Thr Leu Ser Glu Ile Tyr 
            180                 185                 190         


Gln Trp Ile Met Asp Leu Phe Pro Phe Tyr Arg Gln Asn Gln Gln Arg 
        195                 200                 205             


Trp Gln Asn Ser Ile Arg His Ser Leu Ser Phe Asn Asp Cys Phe Leu 
    210                 215                 220                 


Lys Val Pro Arg Ser Pro Asp Lys Pro Gly Lys Gly Ser Phe Trp Thr 
225                 230                 235                 240 


Leu His Pro Asp Ser Gly Asn Met Phe Glu Asn Gly Cys Tyr Leu Arg 
                245                 250                 255     


Arg Gln Lys Arg Phe Lys Cys Glu Lys Gln Leu Ala Leu Lys Glu Ala 
            260                 265                 270         


Ala Gly Ala Ala Gly Ser Gly Lys Lys Ala Ala Ala Gly Ala Gln Ala 
        275                 280                 285             


Ser Gln Ala Gln Leu Gly Glu Ala Ala Gly Pro Ala Ser Glu Thr Pro 
    290                 295                 300                 


Ala Gly Thr Glu Ser Pro His Ser Ser Ala Ser Pro Cys Gln Glu His 
305                 310                 315                 320 


Lys Arg Gly Gly Leu Gly Glu Leu Lys Gly Thr Pro Ala Ala Ala Leu 
                325                 330                 335     


Ser Pro Pro Glu Pro Ala Pro Ser Pro Gly Gln Gln Gln Gln Ala Ala 
            340                 345                 350         


Ala His Leu Leu Gly Pro Pro His His Pro Gly Leu Pro Pro Glu Ala 
        355                 360                 365             


His Leu Lys Pro Glu His His Tyr Ala Phe Asn His Pro Phe Ser Ile 
    370                 375                 380                 


Asn Asn Leu Met Ser Ser Glu Gln Gln His His His Ser His His His 
385                 390                 395                 400 


His Gln Pro His Lys Met Asp Leu Lys Ala Tyr Glu Gln Val Met His 
                405                 410                 415     


Tyr Pro Gly Tyr Gly Ser Pro Met Pro Gly Ser Leu Ala Met Gly Pro 
            420                 425                 430         


Val Thr Asn Lys Thr Gly Leu Asp Ala Ser Pro Leu Ala Ala Asp Thr 
        435                 440                 445             


Ser Tyr Tyr Gln Gly Val Tyr Ser Arg Pro Ile Met Asn Ser Ser 
    450                 455                 460             


<210> 12
<211> 2428
<212> DNA
<213> Homo sapiens

<400> 12
cccgcccact tccaactacc gcctccggcc tgcccaggga gagagaggga gtggagccca       60

gggagaggga gcgcgagaga gggagggagg aggggacggt gctttggctg actttttttt      120

aaaagagggt gggggtgggg ggtgattgct ggtcgtttgt tgtggctgtt aaattttaaa      180

ctgccatgca ctcggcttcc agtatgctgg gagcggtgaa gatggaaggg cacgagccgt      240

ccgactggag cagctactat gcagagcccg agggctactc ctccgtgagc aacatgaacg      300

ccggcctggg gatgaacggc atgaacacgt acatgagcat gtcggcggcc gccatgggca      360

gcggctcggg caacatgagc gcgggctcca tgaacatgtc gtcgtacgtg ggcgctggca      420

tgagcccgtc cctggcgggg atgtcccccg gcgcgggcgc catggcgggc atgggcggct      480

cggccggggc ggccggcgtg gcgggcatgg ggccgcactt gagtcccagc ctgagcccgc      540

tcggggggca ggcggccggg gccatgggcg gcctggcccc ctacgccaac atgaactcca      600

tgagccccat gtacgggcag gcgggcctga gccgcgcccg cgaccccaag acctacaggc      660

gcagctacac gcacgcaaag ccgccctact cgtacatctc gctcatcacc atggccatcc      720

agcagagccc caacaagatg ctgacgctga gcgagatcta ccagtggatc atggacctct      780

tccccttcta ccggcagaac cagcagcgct ggcagaactc catccgccac tcgctctcct      840

tcaacgactg tttcctgaag gtgccccgct cgcccgacaa gcccggcaag ggctccttct      900

ggaccctgca ccctgactcg ggcaacatgt tcgagaacgg ctgctacctg cgccgccaga      960

agcgcttcaa gtgcgagaag cagctggcgc tgaaggaggc cgcaggcgcc gccggcagcg     1020

gcaagaaggc ggccgccgga gcccaggcct cacaggctca actcggggag gccgccgggc     1080

cggcctccga gactccggcg ggcaccgagt cgcctcactc gagcgcctcc ccgtgccagg     1140

agcacaagcg agggggcctg ggagagctga aggggacgcc ggctgcggcg ctgagccccc     1200

cagagccggc gccctctccc gggcagcagc agcaggccgc ggcccacctg ctgggcccgc     1260

cccaccaccc gggcctgccg cctgaggccc acctgaagcc ggaacaccac tacgccttca     1320

accacccgtt ctccatcaac aacctcatgt cctcggagca gcagcaccac cacagccacc     1380

accaccacca accccacaaa atggacctca aggcctacga acaggtgatg cactaccccg     1440

gctacggttc ccccatgcct ggcagcttgg ccatgggccc ggtcacgaac aaaacgggcc     1500

tggacgcctc gcccctggcc gcagatacct cctactacca gggggtgtac tcccggccca     1560

ttatgaactc ctcttaagaa gacgacggct tcaggcccgg ctaactctgg caccccggat     1620

cgaggacaag tgagagagca agtgggggtc gagactttgg ggagacggtg ttgcagagac     1680

gcaagggaga agaaatccat aacaccccca ccccaacacc cccaagacag cagtcttctt     1740

cacccgctgc agccgttccg tcccaaacag agggccacac agatacccca cgttctatat     1800

aaggaggaaa acgggaaaga atataaagtt aaaaaaaagc ctccggtttc cactactgtg     1860

tagactcctg cttcttcaag cacctgcaga ttctgatttt tttgttgttg ttgttctcct     1920

ccattgctgt tgttgcaggg aagtcttact taaaaaaaaa aaaaaatttt gtgagtgact     1980

cggtgtaaaa ccatgtagtt ttaacagaac cagagggttg tactattgtt taaaaacagg     2040

aaaaaaaata atgtaagggt ctgttgtaaa tgaccaagaa aaagaaaaaa aaagcattcc     2100

caatcttgac acggtgaaat ccaggtctcg ggtccgatta atttatggtt tctgcgtgct     2160

ttatttatgg cttataaatg tgtattctgg ctgcaagggc cagagttcca caaatctata     2220

ttaaagtgtt atacccggtt ttatcccttg aatcttttct tccagatttt tcttttcttt     2280

acttggctta caaaatatac aggcttggaa attatttcaa gaaggaggga gggataccct     2340

gtctggttgc aggttgtatt ttattttggc ccagggagtg ttgctgtttt cccaacattt     2400

tattaataaa attttcagac ataaaaaa                                        2428


<210> 13
<211> 595
<212> PRT
<213> Homo sapiens

<400> 13
Met Ala Leu Thr Asp Gly Gly Trp Cys Leu Pro Lys Arg Phe Gly Ala 
1               5                   10                  15      


Ala Gly Ala Asp Ala Ser Asp Ser Arg Ala Phe Pro Ala Arg Glu Pro 
            20                  25                  30          


Ser Thr Pro Pro Ser Pro Ile Ser Ser Ser Ser Ser Ser Cys Ser Arg 
        35                  40                  45              


Gly Gly Glu Arg Gly Pro Gly Gly Ala Ser Asn Cys Gly Thr Pro Gln 
    50                  55                  60                  


Leu Asp Thr Glu Ala Ala Ala Gly Pro Pro Ala Arg Ser Leu Leu Leu 
65                  70                  75                  80  


Ser Ser Tyr Ala Ser His Pro Phe Gly Ala Pro His Gly Pro Ser Ala 
                85                  90                  95      


Pro Gly Val Ala Gly Pro Gly Gly Asn Leu Ser Ser Trp Glu Asp Leu 
            100                 105                 110         


Leu Leu Phe Thr Asp Leu Asp Gln Ala Ala Thr Ala Ser Lys Leu Leu 
        115                 120                 125             


Trp Ser Ser Arg Gly Ala Lys Leu Ser Pro Phe Ala Pro Glu Gln Pro 
    130                 135                 140                 


Glu Glu Met Tyr Gln Thr Leu Ala Ala Leu Ser Ser Gln Gly Pro Ala 
145                 150                 155                 160 


Ala Tyr Asp Gly Ala Pro Gly Gly Phe Val His Ser Ala Ala Ala Ala 
                165                 170                 175     


Ala Ala Ala Ala Ala Ala Ala Ser Ser Pro Val Tyr Val Pro Thr Thr 
            180                 185                 190         


Arg Val Gly Ser Met Leu Pro Gly Leu Pro Tyr His Leu Gln Gly Ser 
        195                 200                 205             


Gly Ser Gly Pro Ala Asn His Ala Gly Gly Ala Gly Ala His Pro Gly 
    210                 215                 220                 


Trp Pro Gln Ala Ser Ala Asp Ser Pro Pro Tyr Gly Ser Gly Gly Gly 
225                 230                 235                 240 


Ala Ala Gly Gly Gly Ala Ala Gly Pro Gly Gly Ala Gly Ser Ala Ala 
                245                 250                 255     


Ala His Val Ser Ala Arg Phe Pro Tyr Ser Pro Ser Pro Pro Met Ala 
            260                 265                 270         


Asn Gly Ala Ala Arg Glu Pro Gly Gly Tyr Ala Ala Ala Gly Ser Gly 
        275                 280                 285             


Gly Ala Gly Gly Val Ser Gly Gly Gly Ser Ser Leu Ala Ala Met Gly 
    290                 295                 300                 


Gly Arg Glu Pro Gln Tyr Ser Ser Leu Ser Ala Ala Arg Pro Leu Asn 
305                 310                 315                 320 


Gly Thr Tyr His His His His His His His His His His Pro Ser Pro 
                325                 330                 335     


Tyr Ser Pro Tyr Val Gly Ala Pro Leu Thr Pro Ala Trp Pro Ala Gly 
            340                 345                 350         


Pro Phe Glu Thr Pro Val Leu His Ser Leu Gln Ser Arg Ala Gly Ala 
        355                 360                 365             


Pro Leu Pro Val Pro Arg Gly Pro Ser Ala Asp Leu Leu Glu Asp Leu 
    370                 375                 380                 


Ser Glu Ser Arg Glu Cys Val Asn Cys Gly Ser Ile Gln Thr Pro Leu 
385                 390                 395                 400 


Trp Arg Arg Asp Gly Thr Gly His Tyr Leu Cys Asn Ala Cys Gly Leu 
                405                 410                 415     


Tyr Ser Lys Met Asn Gly Leu Ser Arg Pro Leu Ile Lys Pro Gln Lys 
            420                 425                 430         


Arg Val Pro Ser Ser Arg Arg Leu Gly Leu Ser Cys Ala Asn Cys His 
        435                 440                 445             


Thr Thr Thr Thr Thr Leu Trp Arg Arg Asn Ala Glu Gly Glu Pro Val 
    450                 455                 460                 


Cys Asn Ala Cys Gly Leu Tyr Met Lys Leu His Gly Val Pro Arg Pro 
465                 470                 475                 480 


Leu Ala Met Lys Lys Glu Gly Ile Gln Thr Arg Lys Arg Lys Pro Lys 
                485                 490                 495     


Asn Ile Asn Lys Ser Lys Thr Cys Ser Gly Asn Ser Asn Asn Ser Ile 
            500                 505                 510         


Pro Met Thr Pro Thr Ser Thr Ser Ser Asn Ser Asp Asp Cys Ser Lys 
        515                 520                 525             


Asn Thr Ser Pro Thr Thr Gln Pro Thr Ala Ser Gly Ala Gly Ala Pro 
    530                 535                 540                 


Val Met Thr Gly Ala Gly Glu Ser Thr Asn Pro Glu Asn Ser Glu Leu 
545                 550                 555                 560 


Lys Tyr Ser Gly Gln Asp Gly Leu Tyr Ile Gly Val Ser Leu Ala Ser 
                565                 570                 575     


Pro Ala Glu Val Thr Ser Ser Val Arg Pro Asp Ser Trp Cys Ala Leu 
            580                 585                 590         


Ala Leu Ala 
        595 


<210> 14
<211> 3785
<212> DNA
<213> Homo sapiens

<400> 14
agttccgacc cacagcctgg cacccttcgg cgagcgctgt ttgtttaggg ctcggtgagt       60

ccaatcagga gcccaggctg cagttttccg gcagagcagt aagaggcgcc tcctctctcc      120

tttttattca ccagcagcgc ggcgcagacc ccggactcgc gctcgcccgc tggcgccctc      180

ggcttctctc cgcgcctggg agcaccctcc gccgcggccg ttctccatgc gcagcgcccg      240

cccgaggagc tagacgtcag cttggagcgg cgccggaccg tggatggcct tgactgacgg      300

cggctggtgc ttgccgaagc gcttcggggc cgcgggtgcg gacgccagcg actccagagc      360

ctttccagcg cgggagccct ccacgccgcc ttcccccatc tcttcctcgt cctcctcctg      420

ctcccggggc ggagagcggg gccccggcgg cgccagcaac tgcgggacgc ctcagctcga      480

cacggaggcg gcggccggac ccccggcccg ctcgctgctg ctcagttcct acgcttcgca      540

tcccttcggg gctccccacg gaccttcggc gcctggggtc gcgggccccg ggggcaacct      600

gtcgagctgg gaggacttgc tgctgttcac tgacctcgac caagccgcga ccgccagcaa      660

gctgctgtgg tccagccgcg gcgccaagct gagccccttc gcacccgagc agccggagga      720

gatgtaccag accctcgccg ctctctccag ccagggtccg gccgcctacg acggcgcgcc      780

cggcggcttc gtgcactctg cggccgcggc ggcagcagcc gcggcggcgg ccagctcccc      840

ggtctacgtg cccaccaccc gcgtgggttc catgctgccc ggcctaccgt accacctgca      900

ggggtcgggc agtgggccag ccaaccacgc gggcggcgcg ggcgcgcacc ccggctggcc      960

tcaggcctcg gccgacagcc ctccatacgg cagcggaggc ggcgcggctg gcggcggggc     1020

cgcggggcct ggcggcgctg gctcagccgc ggcgcacgtc tcggcgcgct tcccctactc     1080

tcccagcccg cccatggcca acggcgccgc gcgggagccg ggaggctacg cggcggcggg     1140

cagtgggggc gcgggaggcg tgagcggcgg cggcagtagc ctggcggcca tgggcggccg     1200

cgagccccag tacagctcgc tgtcggccgc gcggccgctg aacgggacgt accaccacca     1260

ccaccaccac caccaccacc atccgagccc ctactcgccc tacgtggggg cgccactgac     1320

gcctgcctgg cccgccggac ccttcgagac cccggtgctg cacagcctgc agagccgcgc     1380

cggagccccg ctcccggtgc cccggggtcc cagtgcagac ctgctggagg acctgtccga     1440

gagccgcgag tgcgtgaact gcggctccat ccagacgccg ctgtggcggc gggacggcac     1500

cggccactac ctgtgcaacg cctgcgggct ctacagcaag atgaacggcc tcagccggcc     1560

cctcatcaag ccgcagaagc gcgtgccttc atcacggcgg cttggattgt cctgtgccaa     1620

ctgtcacacc acaactacca ccttatggcg cagaaacgcc gagggtgaac ccgtgtgcaa     1680

tgcttgtgga ctctacatga aactccatgg ggtgcccaga ccacttgcta tgaaaaaaga     1740

gggaattcaa accaggaaac gaaaacctaa gaacataaat aaatcaaaga cttgctctgg     1800

taatagcaat aattccattc ccatgactcc aacttccacc tcttctaact cagatgattg     1860

cagcaaaaat acttccccca caacacaacc tacagcctca ggggcgggtg ccccggtgat     1920

gactggtgcg ggagagagca ccaatcccga gaacagcgag ctcaagtatt cgggtcaaga     1980

tgggctctac ataggcgtca gtctcgcctc gccggccgaa gtcacgtcct ccgtgcgacc     2040

ggattcctgg tgcgccctgg ccctggcctg agcccacgcc gccaggaggc agggagggct     2100

ccgccgcggg cctcactcca ctcgtgtctg cttttgtgca gcggtccaga cagtggcgac     2160

tgcgctgaca gaacgtgatt ctcgtgcctt tattttgaaa gagatgtttt tcccaagagg     2220

cttgctgaaa gagtgagaga agatggaagg gaagggccag tgcaactggg cgcttgggcc     2280

actccagcca gcccgcctcc ggggcggacc ctgctccact tccagaagcc aggactagga     2340

cctgggcctt gcctgctatg gaatattgag agagattttt taaaaaagat tttgcatttt     2400

gtccaaaatc atgtgcttct tctgatcaat tttggttgtt ccagaatttc ttcatacctt     2460

ttccacatcc agatttcatg tgcgttcatg gagaagatca cttgaggcca tttggtacac     2520

atctctggag gctgagtcgg ttcatgaggt ctcttatcaa aaatattact cagtttgcaa     2580

gactgcattg taactttaac atacactgtg actgacgttt ctcaaagttc atattgtgtg     2640

gctgatctga agtcagtcgg aatttgtaaa cagggtagca aacaagatat ttttcttcca     2700

tgtatacaat aattttttta aaaagtgcaa tttgcgttgc agcaatcagt gttaaatcat     2760

ttgcataaga tttaacagca ttttttataa tgaatgtaaa cattttaact taatggtact     2820

taaaataatt taaaagaaaa atgttaactt agacattctt atgcttcttt tacaactaca     2880

tcccatttta tatttccaat tgttaaagaa aaatatttca agaacaaatc ttctctcagg     2940

aaaattgcct ttctctattt gttaagaatt tttatacaag aacaccaata tacccccttt     3000

attttactgt ggaatatgtg ctggaaaaat tgcaacaaca ctttactacc taacggatag     3060

catttgtaaa tactctaggt atctgtaaac actctgatga agtctgtata gtgtgactaa     3120

cccacaggca ggttggttta cattaatttt tttttttgaa tgggatgtcc tatggaaacc     3180

tatttcacca gagttttaaa aataaaaagg gtattgtttt gtcttctgta cagtgagttc     3240

cttccctttt caaagctttc tttttatgct gtatgtgact atagatattc atataaaaca     3300

agtgcacgtg aagtttgcaa aatgctttaa ggccttcctt tcaaagcata gtccttttgg     3360

agccgttttg taccttttat accttggctt atttgaagtt gacacatggg gttagttact     3420

actctccatg tgcattgggg acagttttta taagtgggaa ggactcagta ttattatatt     3480

tgagatgata agcattttgt ttgggaacaa tgcttaaaaa tattccagaa agttcagatt     3540

ttttttcttt gtgaatgaaa tatattctgg cccacgaaca gggcgatttc ctttcagttt     3600

tttccttttg caacgtgcct tgaagtctca aagctcacct gaggttgcag acgttacccc     3660

caacagaaga taggtagaaa tgattccagt ggcctctttg tattttcttc attgttgagt     3720

agatttcagg aaatcaggag gtgtttcaca atacagaatg atggccttta actgtgaaaa     3780

aaaaa                                                                 3785


<210> 15
<211> 394
<212> PRT
<213> Homo sapiens

<400> 15
Met Lys Arg Gln Asn Val Arg Thr Leu Ala Leu Ile Val Cys Thr Phe 
1               5                   10                  15      


Thr Tyr Leu Leu Val Gly Ala Ala Val Phe Asp Ala Leu Glu Ser Glu 
            20                  25                  30          


Pro Glu Leu Ile Glu Arg Gln Arg Leu Glu Leu Arg Gln Gln Glu Leu 
        35                  40                  45              


Arg Ala Arg Tyr Asn Leu Ser Gln Gly Gly Tyr Glu Glu Leu Glu Arg 
    50                  55                  60                  


Val Val Leu Arg Leu Lys Pro His Lys Ala Gly Val Gln Trp Arg Phe 
65                  70                  75                  80  


Ala Gly Ser Phe Tyr Phe Ala Ile Thr Val Ile Thr Thr Ile Gly Tyr 
                85                  90                  95      


Gly His Ala Ala Pro Ser Thr Asp Gly Gly Lys Val Phe Cys Met Phe 
            100                 105                 110         


Tyr Ala Leu Leu Gly Ile Pro Leu Thr Leu Val Met Phe Gln Ser Leu 
        115                 120                 125             


Gly Glu Arg Ile Asn Thr Leu Val Arg Tyr Leu Leu His Arg Ala Lys 
    130                 135                 140                 


Lys Gly Leu Gly Met Arg Arg Ala Asp Val Ser Met Ala Asn Met Val 
145                 150                 155                 160 


Leu Ile Gly Phe Phe Ser Cys Ile Ser Thr Leu Cys Ile Gly Ala Ala 
                165                 170                 175     


Ala Phe Ser His Tyr Glu His Trp Thr Phe Phe Gln Ala Tyr Tyr Tyr 
            180                 185                 190         


Cys Phe Ile Thr Leu Thr Thr Ile Gly Phe Gly Asp Tyr Val Ala Leu 
        195                 200                 205             


Gln Lys Asp Gln Ala Leu Gln Thr Gln Pro Gln Tyr Val Ala Phe Ser 
    210                 215                 220                 


Phe Val Tyr Ile Leu Thr Gly Leu Thr Val Ile Gly Ala Phe Leu Asn 
225                 230                 235                 240 


Leu Val Val Leu Arg Phe Met Thr Met Asn Ala Glu Asp Glu Lys Arg 
                245                 250                 255     


Asp Ala Glu His Arg Ala Leu Leu Thr Arg Asn Gly Gln Ala Gly Gly 
            260                 265                 270         


Gly Gly Gly Gly Gly Ser Ala His Thr Thr Asp Thr Ala Ser Ser Thr 
        275                 280                 285             


Ala Ala Ala Gly Gly Gly Gly Phe Arg Asn Val Tyr Ala Glu Val Leu 
    290                 295                 300                 


His Phe Gln Ser Met Cys Ser Cys Leu Trp Tyr Lys Ser Arg Glu Lys 
305                 310                 315                 320 


Leu Gln Tyr Ser Ile Pro Met Ile Ile Pro Arg Asp Leu Ser Thr Ser 
                325                 330                 335     


Asp Thr Cys Val Glu Gln Ser His Ser Ser Pro Gly Gly Gly Gly Arg 
            340                 345                 350         


Tyr Ser Asp Thr Pro Ser Arg Arg Cys Leu Cys Ser Gly Ala Pro Arg 
        355                 360                 365             


Ser Ala Ile Ser Ser Val Ser Thr Gly Leu His Ser Leu Ser Thr Phe 
    370                 375                 380                 


Arg Gly Leu Met Lys Arg Arg Ser Ser Val 
385                 390                 


<210> 16
<211> 3978
<212> DNA
<213> Homo sapiens

<400> 16
ggcggcggcg gcggcggcgg ccccgggcgc tgagcgggtg cccggcgcgg agagcggcga       60

gcgcagccat gccccaggcc gcctccgggg cagcagcagc ggcggccggg gccgaggcgc      120

gggccggggg cgccgggggg ccggcggcgg cccgggcggg acgatgaagc ggcagaacgt      180

gcgcacgctg gcgctcatcg tgtgcacctt cacctacctg ctggtgggcg ccgcggtctt      240

cgacgcgctg gagtcggagc ccgagctgat cgagcggcag cggctggagc tgcggcagca      300

ggagctgcgg gcgcgctaca acctcagcca gggcggctac gaggagctgg agcgcgtcgt      360

gctgcgcctc aagccgcaca aggccggcgt gcagtggcgc ttcgccggct ccttctactt      420

cgccatcacc gtcatcacca ccatcggcta cgggcacgcg gcacccagca cggatggcgg      480

caaggtgttc tgcatgttct acgcgctgct gggcatcccg ctcacgctcg tcatgttcca      540

gagcctgggc gagcgcatca acaccttggt gaggtacctg ctgcaccgcg ccaagaaggg      600

gctgggcatg cggcgcgccg acgtgtccat ggccaacatg gtgctcatcg gcttcttctc      660

gtgcatcagc acgctgtgca tcggcgccgc cgccttctcc cactacgagc actggacctt      720

cttccaggcc tactactact gcttcatcac cctcaccacc atcggcttcg gcgactacgt      780

ggcgctgcag aaggaccagg ccctgcagac gcagccgcag tacgtggcct tcagcttcgt      840

ctacatcctt acgggcctca cggtcatcgg cgccttcctc aacctcgtgg tgctgcgctt      900

catgaccatg aacgccgagg acgagaagcg cgacgccgag caccgcgcgc tgctcacgcg      960

caacgggcag gcgggcggcg gcggaggggg tggcagcgcg cacactacgg acaccgcctc     1020

atccacggcg gcagcgggcg gcggcggctt ccgcaacgtc tacgcggagg tgctgcactt     1080

ccagtccatg tgctcgtgcc tgtggtacaa gagccgcgag aagctgcagt actccatccc     1140

catgatcatc ccgcgggacc tctccacgtc cgacacgtgc gtggagcaga gccactcgtc     1200

gccgggaggg ggcggccgct acagcgacac gccctcgcga cgctgcctgt gcagcggggc     1260

gccacgctcc gccatcagct cggtgtccac gggtctgcac agcctgtcca ccttccgcgg     1320

cctcatgaag cgcaggagct ccgtgtgact gccccgaggg gcctggagca cctgggggcg     1380

cgggcggggg acccctgctg ggaggccagg agactgcccc tgctgccttc tgcccagtgg     1440

gaccccgcac aacatccctc accactctcc cccagcaccc ccatctccga ctgtgcctgc     1500

ttgcaccagc cggcaggagg ccgggctctg aggacccctg gggcccccat cggagccctg     1560

caaattccga gaaatgtgaa acttggtggg gtcagggagg aaaggcagaa gctgggagcc     1620

tcccttccct ttgaaaatct aagaagctcc cagtcctcag agaccctgct ggtacccaga     1680

cccccacctt cggaggggac ttcatgttcc gtgtacgttt gcatctctat ttatacctct     1740

gtcctgctag gtctcccacc ttcccttggt tccaaaagcc agggtgtcta tgtccaagtc     1800

acccctactc agccccactc cccttcctca tccccagctg tgtctcccaa cctcccttcg     1860

tgttgttttg catggctttg cagttatgga gaaagtggaa acccagcagt ccctaaagct     1920

ggtccccaga aagcaggaca gaaagaagga gggacaggca ggcagcagga ggggcgagct     1980

gggaggcagg aggcagcggc ctgtcagtct gcagaatggt cgcactggag gttcaagcta     2040

actggcctcc agccacattc tcatagcagg taggacttca gccttccaga cactgccctt     2100

agaatctgga acagaagact tcagactcac cataattgct gataattacc cactcttaaa     2160

tttgtcgagt gatttttagc ctctgaaaac tctatgctgg ccactgattc ctttgagtct     2220

cacaaaaccc tacttaggtc atcagggcag gagttctcac tcccatttta cagatgagaa     2280

tactgaggcc tggacaggtg aagtgaccag agagcaaaag gcaaaggggt gggggctggg     2340

tgcagtggct cacacctgta ttcccaacac ttttggaggc tgaggttgga ggattgcttg     2400

agcccaggaa tttgagacca gcctaggtga catagtgaga ccccatctct acaaaaaata     2460

aaaaattaac caggtgtggt ggcacgtgcc tgggagtccc agcgacttgg gaggctgagg     2520

tgggaggatt gtttgagcct gggaggtcga ggctgtagtg agccctgatt gcaccactgt     2580

actccagcct gggtgacagg gcaagaccct gtctcaaaaa aaaaaaaaaa aatggcaaag     2640

ggagacaaga gcccagcctg cttgttgcta gccaaagtgt tctttccttc cagcttggcc     2700

tgctcttaaa agcaaagctc ctgcagtgta catcctggca ttgtgtggct acctgggttt     2760

taaaccagaa tcagaagtcc cggatcagag ggcactgctg aggttcagcc tcttctcttc     2820

ttggccagga ggcagcagct ctgaatgggc ccctgaggct gcacaggggc ctttgtcact     2880

ggggcgcatg cttacaaaca gtgcagttct tgggaccgag gtaagcaggg ctgggtctca     2940

tggcagaaag gccaggatct ggggctctag gaatttggga attgggcaga gtggccaaga     3000

aagctggcag gcatatccta tgggacatca cacctggcac cattgtcatt gttggtgcct     3060

gtgtcccaag tagctagtga taagctgagg ctgcagcaag aaacaccctt cccaggtggg     3120

ggagtttgga ccagaggtgc cctctgccca ccacacctgc aacccagaag cccagatgga     3180

acgcagctga cgaaggtgat gcttgaggct cacttttggg gccccacagc tggagccggt     3240

ataatgactg ggacaacatc aaggggtgga tgaggggcct ctcctcccgc aacactgcct     3300

tcccatgctg ttcccctgcc agctccttaa cactgccgac caaggccagc cctggcattc     3360

agggaaattg gagggcagca cccgtagggt ggccagcctc aggccccacc ccagctgtgt     3420

cctctagtct ctggggaccc ctggggggaa gaagtctacc ctgcttgtga gtcccgtctc     3480

agtgtggagg aactggctgc acgtgggacc tgaaggtgcc ctctgtgttt atgttggggg     3540

tgggggggca gtgctggctg cctctgtcct gtgtgtgacc ctgccctcga agggtcctgt     3600

cctgtcagtc ccgagggagc cacaaccaaa gctgcggaga gaaggtgggg aagggtgcag     3660

aatggccgtg gggcacagcg tggcagactg ttcagtctct gctgggtctt tcctagggac     3720

ctggaaggcc agtgttgctt ccccctcact ccctttcact gcaggcagcc tctctgcttc     3780

cccaatgcct tatgcctggg cacactgcca cagaatatgc aatatgtgtg ggtgaccatg     3840

ccctcacgac cacaccccca ccccgggcag cccccggact ccaaaggtcg tggctgccac     3900

agcctccctc agctcttcct gcctatctgt cttcacactg agaatggcgc ccaataaatg     3960

ctatccacgg agaccagg                                                   3978


<210> 17
<211> 676
<212> PRT
<213> Homo sapiens

<400> 17
Met Ala Ala Ala Ser Ser Pro Pro Arg Ala Glu Arg Lys Arg Trp Gly 
1               5                   10                  15      


Trp Gly Arg Leu Pro Gly Ala Arg Arg Gly Ser Ala Gly Leu Ala Lys 
            20                  25                  30          


Lys Cys Pro Phe Ser Leu Glu Leu Ala Glu Gly Gly Pro Ala Gly Gly 
        35                  40                  45              


Ala Leu Tyr Ala Pro Ile Ala Pro Gly Ala Pro Gly Pro Ala Pro Pro 
    50                  55                  60                  


Ala Ser Pro Ala Ala Pro Ala Ala Pro Pro Val Ala Ser Asp Leu Gly 
65                  70                  75                  80  


Pro Arg Pro Pro Val Ser Leu Asp Pro Arg Val Ser Ile Tyr Ser Thr 
                85                  90                  95      


Arg Arg Pro Val Leu Ala Arg Thr His Val Gln Gly Arg Val Tyr Asn 
            100                 105                 110         


Phe Leu Glu Arg Pro Thr Gly Trp Lys Cys Phe Val Tyr His Phe Ala 
        115                 120                 125             


Val Phe Leu Ile Val Leu Val Cys Leu Ile Phe Ser Val Leu Ser Thr 
    130                 135                 140                 


Ile Glu Gln Tyr Ala Ala Leu Ala Thr Gly Thr Leu Phe Trp Met Glu 
145                 150                 155                 160 


Ile Val Leu Val Val Phe Phe Gly Thr Glu Tyr Val Val Arg Leu Trp 
                165                 170                 175     


Ser Ala Gly Cys Arg Ser Lys Tyr Val Gly Leu Trp Gly Arg Leu Arg 
            180                 185                 190         


Phe Ala Arg Lys Pro Ile Ser Ile Ile Asp Leu Ile Val Val Val Ala 
        195                 200                 205             


Ser Met Val Val Leu Cys Val Gly Ser Lys Gly Gln Val Phe Ala Thr 
    210                 215                 220                 


Ser Ala Ile Arg Gly Ile Arg Phe Leu Gln Ile Leu Arg Met Leu His 
225                 230                 235                 240 


Val Asp Arg Gln Gly Gly Thr Trp Arg Leu Leu Gly Ser Val Val Phe 
                245                 250                 255     


Ile His Arg Gln Glu Leu Ile Thr Thr Leu Tyr Ile Gly Phe Leu Gly 
            260                 265                 270         


Leu Ile Phe Ser Ser Tyr Phe Val Tyr Leu Ala Glu Lys Asp Ala Val 
        275                 280                 285             


Asn Glu Ser Gly Arg Val Glu Phe Gly Ser Tyr Ala Asp Ala Leu Trp 
    290                 295                 300                 


Trp Gly Val Val Thr Val Thr Thr Ile Gly Tyr Gly Asp Lys Val Pro 
305                 310                 315                 320 


Gln Thr Trp Val Gly Lys Thr Ile Ala Ser Cys Phe Ser Val Phe Ala 
                325                 330                 335     


Ile Ser Phe Phe Ala Leu Pro Ala Gly Ile Leu Gly Ser Gly Phe Ala 
            340                 345                 350         


Leu Lys Val Gln Gln Lys Gln Arg Gln Lys His Phe Asn Arg Gln Ile 
        355                 360                 365             


Pro Ala Ala Ala Ser Leu Ile Gln Thr Ala Trp Arg Cys Tyr Ala Ala 
    370                 375                 380                 


Glu Asn Pro Asp Ser Ser Thr Trp Lys Ile Tyr Ile Arg Lys Ala Pro 
385                 390                 395                 400 


Arg Ser His Thr Leu Leu Ser Pro Ser Pro Lys Pro Lys Lys Ser Val 
                405                 410                 415     


Val Val Lys Lys Lys Lys Phe Lys Leu Asp Lys Asp Asn Gly Val Thr 
            420                 425                 430         


Pro Gly Glu Lys Met Leu Thr Val Pro His Ile Thr Cys Asp Pro Pro 
        435                 440                 445             


Glu Glu Arg Arg Leu Asp His Phe Ser Val Asp Gly Tyr Asp Ser Ser 
    450                 455                 460                 


Val Arg Lys Ser Pro Thr Leu Leu Glu Val Ser Met Pro His Phe Met 
465                 470                 475                 480 


Arg Thr Asn Ser Phe Ala Glu Asp Leu Asp Leu Glu Gly Glu Thr Leu 
                485                 490                 495     


Leu Thr Pro Ile Thr His Ile Ser Gln Leu Arg Glu His His Arg Ala 
            500                 505                 510         


Thr Ile Lys Val Ile Arg Arg Met Gln Tyr Phe Val Ala Lys Lys Lys 
        515                 520                 525             


Phe Gln Gln Ala Arg Lys Pro Tyr Asp Val Arg Asp Val Ile Glu Gln 
    530                 535                 540                 


Tyr Ser Gln Gly His Leu Asn Leu Met Val Arg Ile Lys Glu Leu Gln 
545                 550                 555                 560 


Arg Arg Leu Asp Gln Ser Ile Gly Lys Pro Ser Leu Phe Ile Ser Val 
                565                 570                 575     


Ser Glu Lys Ser Lys Asp Arg Gly Ser Asn Thr Ile Gly Ala Arg Leu 
            580                 585                 590         


Asn Arg Val Glu Asp Lys Val Thr Gln Leu Asp Gln Arg Leu Ala Leu 
        595                 600                 605             


Ile Thr Asp Met Leu His Gln Leu Leu Ser Leu His Gly Gly Ser Thr 
    610                 615                 620                 


Pro Gly Ser Gly Gly Pro Pro Arg Glu Gly Gly Ala His Ile Thr Gln 
625                 630                 635                 640 


Pro Cys Gly Ser Gly Gly Ser Val Asp Pro Glu Leu Phe Leu Pro Ser 
                645                 650                 655     


Asn Thr Leu Pro Thr Tyr Glu Gln Leu Thr Val Pro Arg Arg Gly Pro 
            660                 665                 670         


Asp Glu Gly Ser 
        675     


<210> 18
<211> 3262
<212> DNA
<213> Homo sapiens

<400> 18
gcggcggggc tggcagcagt ggctgcccgc actgcgcccg ggcgctcgcc ttcgctgcag       60

ctcccggtgc cgccgctcgg gccggccccc cggcaggccc tcctcgttat ggccgcggcc      120

tcctccccgc ccagggccga gaggaagcgc tggggttggg gccgcctgcc aggcgcccgg      180

cggggcagcg cgggcctggc caagaagtgc cccttctcgc tggagctggc ggagggcggc      240

ccggcgggcg gcgcgctcta cgcgcccatc gcgcccggcg ccccaggtcc cgcgccccct      300

gcgtccccgg ccgcgcccgc cgcgccccca gttgcctccg accttggccc gcggccgccg      360

gtgagcctag acccgcgcgt ctccatctac agcacgcgcc gcccggtgtt ggcgcgcacc      420

cacgtccagg gccgcgtcta caacttcctc gagcgtccca ccggctggaa atgcttcgtt      480

taccacttcg ccgtcttcct catcgtcctg gtctgcctca tcttcagcgt gctgtccacc      540

atcgagcagt atgccgccct ggccacgggg actctcttct ggatggagat cgtgctggtg      600

gtgttcttcg ggacggagta cgtggtccgc ctctggtccg ccggctgccg cagcaagtac      660

gtgggcctct gggggcggct gcgctttgcc cggaagccca tttccatcat cgacctcatc      720

gtggtcgtgg cctccatggt ggtcctctgc gtgggctcca aggggcaggt gtttgccacg      780

tcggccatca ggggcatccg cttcctgcag atcctgagga tgctacacgt cgaccgccag      840

ggaggcacct ggaggctcct gggctccgtg gtcttcatcc accgccagga gctgataacc      900

accctgtaca tcggcttcct gggcctcatc ttctcctcgt actttgtgta cctggctgag      960

aaggacgcgg tgaacgagtc aggccgcgtg gagttcggca gctacgcaga tgcgctgtgg     1020

tggggggtgg tcacagtcac caccatcggc tatggggaca aggtgcccca gacgtgggtc     1080

gggaagacca tcgcctcctg cttctctgtc tttgccatct ccttctttgc gctcccagcg     1140

gggattcttg gctcggggtt tgccctgaag gtgcagcaga agcagaggca gaagcacttc     1200

aaccggcaga tcccggcggc agcctcactc attcagaccg catggaggtg ctatgctgcc     1260

gagaaccccg actcctccac ctggaagatc tacatccgga aggccccccg gagccacact     1320

ctgctgtcac ccagccccaa acccaagaag tctgtggtgg taaagaaaaa aaagttcaag     1380

ctggacaaag acaatggggt gactcctgga gagaagatgc tcacagtccc ccatatcacg     1440

tgcgaccccc cagaagagcg gcggctggac cacttctctg tcgacggcta tgacagttct     1500

gtaaggaaga gcccaacact gctggaagtg agcatgcccc atttcatgag aaccaacagc     1560

ttcgccgagg acctggacct ggaaggggag actctgctga cacccatcac ccacatctca     1620

cagctgcggg aacaccatcg ggccaccatt aaggtcattc gacgcatgca gtactttgtg     1680

gccaagaaga aattccagca agcgcggaag ccttacgatg tgcgggacgt cattgagcag     1740

tactcgcagg gccacctcaa cctcatggtg cgcatcaagg agctgcagag gaggctggac     1800

cagtccattg ggaagccctc actgttcatc tccgtctcag aaaagagcaa ggatcgcggc     1860

agcaacacga tcggcgcccg cctgaaccga gtagaagaca aggtgacgca gctggaccag     1920

aggctggcac tcatcaccga catgcttcac cagctgctct ccttgcacgg tggcagcacc     1980

cccggcagcg gcggcccccc cagagagggc ggggcccaca tcacccagcc ctgcggcagt     2040

ggcggctccg tcgaccctga gctcttcctg cccagcaaca ccctgcccac ctacgagcag     2100

ctgaccgtgc ccaggagggg ccccgatgag gggtcctgag gaggggatgg ggctggggga     2160

tgggcctgag tgagagggga ggccaagagt ggccccacct ggccctctct gaaggaggcc     2220

acctcctaaa aggcccagag agaagagccc cactctcaga ggccccaata ccccatggac     2280

catgctgtct ggcacagcct gcacttgggg gctcagcaag gccacctctt cctggccggt     2340

gtgggggccc cgtctcaggt ctgagttgtt accccaagcg ccctggcccc cacatggtga     2400

tgttgacatc actggcatgg tggttgggac ccagtggcag ggcacagggc ctggcccatg     2460

tatggccagg aagtagcaca ggctgagtgc aggcccaccc tgcttggccc agggggcttc     2520

ctgaggggag acagagcaac ccctggaccc cagcctcaaa tccaggaccc tgccaggcac     2580

aggcagggca ggaccagccc acgctgacta cagggccgcc ggcaataaaa gcccaggagc     2640

ccatttggag ggcctgggcc tggctccctc actctcagga aatgctgacc catgggcagg     2700

agactgtgga gactgctcct gagcccccag cttccagcag gagggacagt ctcaccattt     2760

ccccagggca cgtggttgag tggggggaac gcccacttcc ctgggttaga ctgccagctc     2820

ttcctagctg gagaggagcc ctgcctctcc gcccctgagc ccactgtgcg tggggctccc     2880

gcctccaacc cctcgcccag tcccagcagc cagccaaaca cacagaaggg gactgccacc     2940

tccccttgcc agctgctgag ccgcagagaa gtgacggttc ctacacagga caggggttcc     3000

ttctgggcat tacatcgcat agaaatcaat aatttgtggt gatttggatc tgtgttttaa     3060

tgagtttcac agtgtgattt tgattattaa ttgtgcaagc ttttcctaat aaacgtggag     3120

aatcacaggc tgggctgggc actgctctca ccttggttcc tggggcatcc atggggtctc     3180

tcacagacag gacccctgca gttcccctgg aagcagtgcc caggtggctg tggaatagga     3240

acgctaaaaa aaaaaaaaaa aa                                              3262


<210> 19
<211> 907
<212> PRT
<213> Homo sapiens

<400> 19
Met Asp Thr Ser Arg Leu Gly Val Leu Leu Ser Leu Pro Val Leu Leu 
1               5                   10                  15      


Gln Leu Ala Thr Gly Gly Ser Ser Pro Arg Ser Gly Val Leu Leu Arg 
            20                  25                  30          


Gly Cys Pro Thr His Cys His Cys Glu Pro Asp Gly Arg Met Leu Leu 
        35                  40                  45              


Arg Val Asp Cys Ser Asp Leu Gly Leu Ser Glu Leu Pro Ser Asn Leu 
    50                  55                  60                  


Ser Val Phe Thr Ser Tyr Leu Asp Leu Ser Met Asn Asn Ile Ser Gln 
65                  70                  75                  80  


Leu Leu Pro Asn Pro Leu Pro Ser Leu Arg Phe Leu Glu Glu Leu Arg 
                85                  90                  95      


Leu Ala Gly Asn Ala Leu Thr Tyr Ile Pro Lys Gly Ala Phe Thr Gly 
            100                 105                 110         


Leu Tyr Ser Leu Lys Val Leu Met Leu Gln Asn Asn Gln Leu Arg His 
        115                 120                 125             


Val Pro Thr Glu Ala Leu Gln Asn Leu Arg Ser Leu Gln Ser Leu Arg 
    130                 135                 140                 


Leu Asp Ala Asn His Ile Ser Tyr Val Pro Pro Ser Cys Phe Ser Gly 
145                 150                 155                 160 


Leu His Ser Leu Arg His Leu Trp Leu Asp Asp Asn Ala Leu Thr Glu 
                165                 170                 175     


Ile Pro Val Gln Ala Phe Arg Ser Leu Ser Ala Leu Gln Ala Met Thr 
            180                 185                 190         


Leu Ala Leu Asn Lys Ile His His Ile Pro Asp Tyr Ala Phe Gly Asn 
        195                 200                 205             


Leu Ser Ser Leu Val Val Leu His Leu His Asn Asn Arg Ile His Ser 
    210                 215                 220                 


Leu Gly Lys Lys Cys Phe Asp Gly Leu His Ser Leu Glu Thr Leu Asp 
225                 230                 235                 240 


Leu Asn Tyr Asn Asn Leu Asp Glu Phe Pro Thr Ala Ile Arg Thr Leu 
                245                 250                 255     


Ser Asn Leu Lys Glu Leu Gly Phe His Ser Asn Asn Ile Arg Ser Ile 
            260                 265                 270         


Pro Glu Lys Ala Phe Val Gly Asn Pro Ser Leu Ile Thr Ile His Phe 
        275                 280                 285             


Tyr Asp Asn Pro Ile Gln Phe Val Gly Arg Ser Ala Phe Gln His Leu 
    290                 295                 300                 


Pro Glu Leu Arg Thr Leu Thr Leu Asn Gly Ala Ser Gln Ile Thr Glu 
305                 310                 315                 320 


Phe Pro Asp Leu Thr Gly Thr Ala Asn Leu Glu Ser Leu Thr Leu Thr 
                325                 330                 335     


Gly Ala Gln Ile Ser Ser Leu Pro Gln Thr Val Cys Asn Gln Leu Pro 
            340                 345                 350         


Asn Leu Gln Val Leu Asp Leu Ser Tyr Asn Leu Leu Glu Asp Leu Pro 
        355                 360                 365             


Ser Phe Ser Val Cys Gln Lys Leu Gln Lys Ile Asp Leu Arg His Asn 
    370                 375                 380                 


Glu Ile Tyr Glu Ile Lys Val Asp Thr Phe Gln Gln Leu Leu Ser Leu 
385                 390                 395                 400 


Arg Ser Leu Asn Leu Ala Trp Asn Lys Ile Ala Ile Ile His Pro Asn 
                405                 410                 415     


Ala Phe Ser Thr Leu Pro Ser Leu Ile Lys Leu Asp Leu Ser Ser Asn 
            420                 425                 430         


Leu Leu Ser Ser Phe Pro Ile Thr Gly Leu His Gly Leu Thr His Leu 
        435                 440                 445             


Lys Leu Thr Gly Asn His Ala Leu Gln Ser Leu Ile Ser Ser Glu Asn 
    450                 455                 460                 


Phe Pro Glu Leu Lys Val Ile Glu Met Pro Tyr Ala Tyr Gln Cys Cys 
465                 470                 475                 480 


Ala Phe Gly Val Cys Glu Asn Ala Tyr Lys Ile Ser Asn Gln Trp Asn 
                485                 490                 495     


Lys Gly Asp Asn Ser Ser Met Asp Asp Leu His Lys Lys Asp Ala Gly 
            500                 505                 510         


Met Phe Gln Ala Gln Asp Glu Arg Asp Leu Glu Asp Phe Leu Leu Asp 
        515                 520                 525             


Phe Glu Glu Asp Leu Lys Ala Leu His Ser Val Gln Cys Ser Pro Ser 
    530                 535                 540                 


Pro Gly Pro Phe Lys Pro Cys Glu His Leu Leu Asp Gly Trp Leu Ile 
545                 550                 555                 560 


Arg Ile Gly Val Trp Thr Ile Ala Val Leu Ala Leu Thr Cys Asn Ala 
                565                 570                 575     


Leu Val Thr Ser Thr Val Phe Arg Ser Pro Leu Tyr Ile Ser Pro Ile 
            580                 585                 590         


Lys Leu Leu Ile Gly Val Ile Ala Ala Val Asn Met Leu Thr Gly Val 
        595                 600                 605             


Ser Ser Ala Val Leu Ala Gly Val Asp Ala Phe Thr Phe Gly Ser Phe 
    610                 615                 620                 


Ala Arg His Gly Ala Trp Trp Glu Asn Gly Val Gly Cys His Val Ile 
625                 630                 635                 640 


Gly Phe Leu Ser Ile Phe Ala Ser Glu Ser Ser Val Phe Leu Leu Thr 
                645                 650                 655     


Leu Ala Ala Leu Glu Arg Gly Phe Ser Val Lys Tyr Ser Ala Lys Phe 
            660                 665                 670         


Glu Thr Lys Ala Pro Phe Ser Ser Leu Lys Val Ile Ile Leu Leu Cys 
        675                 680                 685             


Ala Leu Leu Ala Leu Thr Met Ala Ala Val Pro Leu Leu Gly Gly Ser 
    690                 695                 700                 


Lys Tyr Gly Ala Ser Pro Leu Cys Leu Pro Leu Pro Phe Gly Glu Pro 
705                 710                 715                 720 


Ser Thr Met Gly Tyr Met Val Ala Leu Ile Leu Leu Asn Ser Leu Cys 
                725                 730                 735     


Phe Leu Met Met Thr Ile Ala Tyr Thr Lys Leu Tyr Cys Asn Leu Asp 
            740                 745                 750         


Lys Gly Asp Leu Glu Asn Ile Trp Asp Cys Ser Met Val Lys His Ile 
        755                 760                 765             


Ala Leu Leu Leu Phe Thr Asn Cys Ile Leu Asn Cys Pro Val Ala Phe 
    770                 775                 780                 


Leu Ser Phe Ser Ser Leu Ile Asn Leu Thr Phe Ile Ser Pro Glu Val 
785                 790                 795                 800 


Ile Lys Phe Ile Leu Leu Val Val Val Pro Leu Pro Ala Cys Leu Asn 
                805                 810                 815     


Pro Leu Leu Tyr Ile Leu Phe Asn Pro His Phe Lys Glu Asp Leu Val 
            820                 825                 830         


Ser Leu Arg Lys Gln Thr Tyr Val Trp Thr Arg Ser Lys His Pro Ser 
        835                 840                 845             


Leu Met Ser Ile Asn Ser Asp Asp Val Glu Lys Gln Ser Cys Asp Ser 
    850                 855                 860                 


Thr Gln Ala Leu Val Thr Phe Thr Ser Ser Ser Ile Thr Tyr Asp Leu 
865                 870                 875                 880 


Pro Pro Ser Ser Val Pro Ser Pro Ala Tyr Pro Val Thr Glu Ser Cys 
                885                 890                 895     


His Leu Ser Ser Val Ala Phe Val Pro Cys Leu 
            900                 905         


<210> 20
<211> 4625
<212> DNA
<213> Homo sapiens

<400> 20
aaaaaacgag cgtgcaagca gagatgctgc tccacaccgc tcaggccgcg agcagcagca       60

aggcgcaccg ccactgtcgc cgctgcagcc agggctgctc cgaaggccgg cgtggcggca      120

accggcacct ctgtccccgc cgcgcttctc ctcgccgccc acgccgtggg gtcaggaacg      180

cggcgtctgg cgctgcagac gcccgctgag ttgcagaagc ccacggagcg gcgcccggcg      240

cgccacggcc cgtagcagtc cggtgctgct ctccgcccgc gtccggctcg tggcccccta      300

cttcgggcac catggacacc tcccggctcg gtgtgctcct gtccttgcct gtgctgctgc      360

agctggcgac cgggggcagc tctcccaggt ctggtgtgtt gctgaggggc tgccccacac      420

actgtcattg cgagcccgac ggcaggatgt tgctcagggt ggactgctcc gacctggggc      480

tctcggagct gccttccaac ctcagcgtct tcacctccta cctagacctc agtatgaaca      540

acatcagtca gctgctcccg aatcccctgc ccagtctccg cttcctggag gagttacgtc      600

ttgcgggaaa cgctctgaca tacattccca agggagcatt cactggcctt tacagtctta      660

aagttcttat gctgcagaat aatcagctaa gacacgtacc cacagaagct ctgcagaatt      720

tgcgaagcct tcaatccctg cgtctggatg ctaaccacat cagctatgtg cccccaagct      780

gtttcagtgg cctgcattcc ctgaggcacc tgtggctgga tgacaatgcg ttaacagaaa      840

tccccgtcca ggcttttaga agtttatcgg cattgcaagc catgaccttg gccctgaaca      900

aaatacacca cataccagac tatgcctttg gaaacctctc cagcttggta gttctacatc      960

tccataacaa tagaatccac tccctgggaa agaaatgctt tgatgggctc cacagcctag     1020

agactttaga tttaaattac aataaccttg atgaattccc cactgcaatt aggacactct     1080

ccaaccttaa agaactagga tttcatagca acaatatcag gtcgatacct gagaaagcat     1140

ttgtaggcaa cccttctctt attacaatac atttctatga caatcccatc cagtttgttg     1200

ggagatctgc ttttcaacat ttacctgaac taagaacact gactctgaat ggtgcctcac     1260

aaataactga atttcctgat ttaactggaa ctgcaaacct ggagagtctg actttaactg     1320

gagcacagat ctcatctctt cctcaaaccg tctgcaatca gttacctaat ctccaagtgc     1380

tagatctgtc ttacaaccta ttagaagatt tacccagttt ttcagtctgc caaaagcttc     1440

agaaaattga cctaagacat aatgaaatct acgaaattaa agttgacact ttccagcagt     1500

tgcttagcct ccgatcgctg aatttggctt ggaacaaaat tgctattatt caccccaatg     1560

cattttccac tttgccatcc ctaataaagc tggacctatc gtccaacctc ctgtcgtctt     1620

ttcctataac tgggttacat ggtttaactc acttaaaatt aacaggaaat catgccttac     1680

agagcttgat atcatctgaa aactttccag aactcaaggt tatagaaatg ccttatgctt     1740

accagtgctg tgcatttgga gtgtgtgaga atgcctataa gatttctaat caatggaata     1800

aaggtgacaa cagcagtatg gacgaccttc ataagaaaga tgctggaatg tttcaggctc     1860

aagatgaacg tgaccttgaa gatttcctgc ttgactttga ggaagacctg aaagcccttc     1920

attcagtgca gtgttcacct tccccaggcc ccttcaaacc ctgtgaacac ctgcttgatg     1980

gctggctgat cagaattgga gtgtggacca tagcagttct ggcacttact tgtaatgctt     2040

tggtgacttc aacagttttc agatcccctc tgtacatttc ccccattaaa ctgttaattg     2100

gggtcatcgc agcagtgaac atgctcacgg gagtctccag tgccgtgctg gctggtgtgg     2160

atgcgttcac ttttggcagc tttgcacgac atggtgcctg gtgggagaat ggggttggtt     2220

gccatgtcat tggttttttg tccatttttg cttcagaatc atctgttttc ctgcttactc     2280

tggcagccct ggagcgtggg ttctctgtga aatattctgc aaaatttgaa acgaaagctc     2340

cattttctag cctgaaagta atcattttgc tctgtgccct gctggccttg accatggccg     2400

cagttcccct gctgggtggc agcaagtatg gcgcctcccc tctctgcctg cctttgcctt     2460

ttggggagcc cagcaccatg ggctacatgg tcgctctcat cttgctcaat tccctttgct     2520

tcctcatgat gaccattgcc tacaccaagc tctactgcaa tttggacaag ggagacctgg     2580

agaatatttg ggactgctct atggtaaaac acattgccct gttgctcttc accaactgca     2640

tcctaaactg ccctgtggct ttcttgtcct tctcctcttt aataaacctt acatttatca     2700

gtcctgaagt aattaagttt atccttctgg tggtagtccc acttcctgca tgtctcaatc     2760

cccttctcta catcttgttc aatcctcact ttaaggagga tctggtgagc ctgagaaagc     2820

aaacctacgt ctggacaaga tcaaaacacc caagcttgat gtcaattaac tctgatgatg     2880

tcgaaaaaca gtcctgtgac tcaactcaag ccttggtaac ctttaccagc tccagcatca     2940

cttatgacct gcctcccagt tccgtgccat caccagctta tccagtgact gagagctgcc     3000

atctttcctc tgtggcattt gtcccatgtc tctaattaat atgtgaagga aaatgttttc     3060

aaaggttgag aacctgaaaa tgtgagattg agtatatcag agcagtaatt aataagaaga     3120

gctgaggtga aactcggttt aaaaaccaaa aaagaatctc tcagttagta agaaaaggct     3180

gaaaacctct tgatacttga gagtgaatat aagtctaaat gctgctttgt ataatttgtt     3240

cagctaaggg atagatcgat cacactattt aagtgagccc agatcaaaaa agcagattga     3300

aattttcttt agaaaagatt ctccatgatt tgaattgcat tctctttaaa ctcaccaatg     3360

taatcatttt gggaggaggg agaacccact tgctttccaa atgggtttat ttaaacccac     3420

aaactcaaga ggttgttggg ggaattagga aaataagggt tttcaatgac ctacattgct     3480

aggtagaggc tgtgatccat gggatttcat tctaatgacc atgtgaagat gtttgagtcc     3540

tcctttgcct ttcctcagaa agaatccttc taaggcacaa atcccttaga tggataatgt     3600

aaggtattgt taactcactc atattgagat catttttaga gataccaggt tttatgtatc     3660

agcactagat ggttccaccc tcatgggata aaactgctta caagtatttt gaaagaaaaa     3720

ctgaccaaaa ttcttaaatt gttactaagg caatcatgca caggtgacgt atgtcttatc     3780

tgatttgttt ttaactcctt ggtgcccaaa gctcagaagg gaattccact gccagcaatg     3840

aacatacctg gaaaagaaag taagcaatct gggatttttt ttctgggtta gtaaagaatt     3900

tttgcaataa gttttatcag ttgattcaaa ctgatgtgca tcttaatgat caaatgtgca     3960

cattacataa attaagtcca ctgatacaac ttcttacaca tgtatctcta gtagctctgg     4020

caaacccaat atctgacacc actttggact caagagactc agtaacgtat tatcctgttt     4080

atttagcttg gttttagctg tgttctctct ggataaccca cttgatgtta ggaacattac     4140

ttctctgctt attccatatt aatactgtgt taggtatttt aagaagcaag ttattaaata     4200

agaaaagtca aagtattaat tcttaccttc tattatccta tattagcttc aatacatcca     4260

aaccaaatgg ctgttaggta gatttatttt tatataagca tgtttatttt gatcagatgt     4320

tttaacttgg atttgaaaaa atacatttat gagatgtttt ataagatgtg taaatataga     4380

actgtattta ttactatagt aaaggttcag taacattaag gaccatgata atgataataa     4440

accttgtaca gtggcatatt ctttgattta tattgtgttt ctctgcccat tttctttaaa     4500

ttcattaact gtatatatgt aaatatatag tacttgtaaa tagattccaa atttgctttt     4560

ctattgggta aaaaataaat ttgtaataaa atgtgtgact atgaaacaaa aaaaaaaaaa     4620

aaaaa                                                                 4625


<210> 21
<211> 332
<212> PRT
<213> Homo sapiens

<400> 21
Met Ala Thr Leu Lys Asp Gln Leu Ile Tyr Asn Leu Leu Lys Glu Glu 
1               5                   10                  15      


Gln Thr Pro Gln Asn Lys Ile Thr Val Val Gly Val Gly Ala Val Gly 
            20                  25                  30          


Met Ala Cys Ala Ile Ser Ile Leu Met Lys Asp Leu Ala Asp Glu Leu 
        35                  40                  45              


Ala Leu Val Asp Val Ile Glu Asp Lys Leu Lys Gly Glu Met Met Asp 
    50                  55                  60                  


Leu Gln His Gly Ser Leu Phe Leu Arg Thr Pro Lys Ile Val Ser Gly 
65                  70                  75                  80  


Lys Asp Tyr Asn Val Thr Ala Asn Ser Lys Leu Val Ile Ile Thr Ala 
                85                  90                  95      


Gly Ala Arg Gln Gln Glu Gly Glu Ser Arg Leu Asn Leu Val Gln Arg 
            100                 105                 110         


Asn Val Asn Ile Phe Lys Phe Ile Ile Pro Asn Val Val Lys Tyr Ser 
        115                 120                 125             


Pro Asn Cys Lys Leu Leu Ile Val Ser Asn Pro Val Asp Ile Leu Thr 
    130                 135                 140                 


Tyr Val Ala Trp Lys Ile Ser Gly Phe Pro Lys Asn Arg Val Ile Gly 
145                 150                 155                 160 


Ser Gly Cys Asn Leu Asp Ser Ala Arg Phe Arg Tyr Leu Met Gly Glu 
                165                 170                 175     


Arg Leu Gly Val His Pro Leu Ser Cys His Gly Trp Val Leu Gly Glu 
            180                 185                 190         


His Gly Asp Ser Ser Val Pro Val Trp Ser Gly Met Asn Val Ala Gly 
        195                 200                 205             


Val Ser Leu Lys Thr Leu His Pro Asp Leu Gly Thr Asp Lys Asp Lys 
    210                 215                 220                 


Glu Gln Trp Lys Glu Val His Lys Gln Val Val Glu Ser Ala Tyr Glu 
225                 230                 235                 240 


Val Ile Lys Leu Lys Gly Tyr Thr Ser Trp Ala Ile Gly Leu Ser Val 
                245                 250                 255     


Ala Asp Leu Ala Glu Ser Ile Met Lys Asn Leu Arg Arg Val His Pro 
            260                 265                 270         


Val Ser Thr Met Ile Lys Gly Leu Tyr Gly Ile Lys Asp Asp Val Phe 
        275                 280                 285             


Leu Ser Val Pro Cys Ile Leu Gly Gln Asn Gly Ile Ser Asp Leu Val 
    290                 295                 300                 


Lys Val Thr Leu Thr Ser Glu Glu Glu Ala Arg Leu Lys Lys Ser Ala 
305                 310                 315                 320 


Asp Thr Leu Trp Gly Ile Gln Lys Glu Leu Gln Phe 
                325                 330         


<210> 22
<211> 2226
<212> DNA
<213> Homo sapiens

<400> 22
gtctgccggt cggttgtctg gctgcgcgcg ccacccgggc ctctccagtg ccccgcctgg       60

ctcggcatcc acccccagcc cgactcacac gtgggttccc gcacgtccgc cggccccccc      120

cgctgacgtc agcatagctg ttccacttaa ggcccctccc gcgcccagct cagagtgctg      180

cagccgctgc cgccgattcc ggatctcatt gccacgcgcc cccgacgacc gcccgacgtg      240

cattcccgat tccttttggt tccaagtcca atatggcaac tctaaaggat cagctgattt      300

ataatcttct aaaggaagaa cagacccccc agaataagat tacagttgtt ggggttggtg      360

ctgttggcat ggcctgtgcc atcagtatct taatgaagga cttggcagat gaacttgctc      420

ttgttgatgt catcgaagac aaattgaagg gagagatgat ggatctccaa catggcagcc      480

ttttccttag aacaccaaag attgtctctg gcaaagacta taatgtaact gcaaactcca      540

agctggtcat tatcacggct ggggcacgtc agcaagaggg agaaagccgt cttaatttgg      600

tccagcgtaa cgtgaacatc tttaaattca tcattcctaa tgttgtaaaa tacagcccga      660

actgcaagtt gcttattgtt tcaaatccag tggatatctt gacctacgtg gcttggaaga      720

taagtggttt tcccaaaaac cgtgttattg gaagcggttg caatctggat tcagcccgat      780

tccgttacct aatgggggaa aggctgggag ttcacccatt aagctgtcat gggtgggtcc      840

ttggggaaca tggagattcc agtgtgcctg tatggagtgg aatgaatgtt gctggtgtct      900

ctctgaagac tctgcaccca gatttaggga ctgataaaga taaggaacag tggaaagagg      960

ttcacaagca ggtggttgag agtgcttatg aggtgatcaa actcaaaggc tacacatcct     1020

gggctattgg actctctgta gcagatttgg cagagagtat aatgaagaat cttaggcggg     1080

tgcacccagt ttccaccatg attaagggtc tttacggaat aaaggatgat gtcttcctta     1140

gtgttccttg cattttggga cagaatggaa tctcagacct tgtgaaggtg actctgactt     1200

ctgaggaaga ggcccgtttg aagaagagtg cagatacact ttgggggatc caaaaggagc     1260

tgcaatttta aagtcttctg atgtcatatc atttcactgt ctaggctaca acaggattct     1320

aggtggaggt tgtgcatgtt gtccttttta tctgatctgt gattaaagca gtaatatttt     1380

aagatggact gggaaaaaca tcaactcctg aagttagaaa taagaatggt ttgtaaaatc     1440

cacagctata tcctgatgct ggatggtatt aatcttgtgt agtcttcaac tggttagtgt     1500

gaaatagttc tgccacctct gacgcaccac tgccaatgct gtacgtactg catttgcccc     1560

ttgagccagg tggatgttta ccgtgtgtta tataacttcc tggctccttc actgaacatg     1620

cctagtccaa cattttttcc cagtgagtca catcctggga tccagtgtat aaatccaata     1680

tcatgtcttg tgcataattc ttccaaagga tcttattttg tgaactatat cagtagtgta     1740

cattaccata taatgtaaaa agatctacat acaaacaatg caaccaacta tccaagtgtt     1800

ataccaacta aaacccccaa taaaccttga acagtgacta ctttggttaa ttcattatat     1860

taagatataa agtcataaag ctgctagtta ttatattaat ttggaaatat taggctattc     1920

ttgggcaacc ctgcaacgat tttttctaac agggatatta ttgactaata gcagaggatg     1980

taatagtcaa ctgagttgta ttggtaccac ttccattgta agtcccaaag tattatatat     2040

ttgataataa tgctaatcat aattggaaag taacattcta tatgtaaatg taaaatttat     2100

ttgccaactg aatataggca atgatagtgt gtcactatag ggaacacaga tttttgagat     2160

cttgtcctct ggaagctggt aacaattaaa aacaatctta aggcagggaa aaaaaaaaaa     2220

aaaaaa                                                                2226


<210> 23
<211> 353
<212> PRT
<213> Homo sapiens

<400> 23
Met Ala Ala Glu Leu Ala Met Gly Ala Glu Leu Pro Ser Ser Pro Leu 
1               5                   10                  15      


Ala Ile Glu Tyr Val Asn Asp Phe Asp Leu Met Lys Phe Glu Val Lys 
            20                  25                  30          


Lys Glu Pro Pro Glu Ala Glu Arg Phe Cys His Arg Leu Pro Pro Gly 
        35                  40                  45              


Ser Leu Ser Ser Thr Pro Leu Ser Thr Pro Cys Ser Ser Val Pro Ser 
    50                  55                  60                  


Ser Pro Ser Phe Cys Ala Pro Ser Pro Gly Thr Gly Gly Gly Gly Gly 
65                  70                  75                  80  


Ala Gly Gly Gly Gly Gly Ser Ser Gln Ala Gly Gly Ala Pro Gly Pro 
                85                  90                  95      


Pro Ser Gly Gly Pro Gly Ala Val Gly Gly Thr Ser Gly Lys Pro Ala 
            100                 105                 110         


Leu Glu Asp Leu Tyr Trp Met Ser Gly Tyr Gln His His Leu Asn Pro 
        115                 120                 125             


Glu Ala Leu Asn Leu Thr Pro Glu Asp Ala Val Glu Ala Leu Ile Gly 
    130                 135                 140                 


Ser Gly His His Gly Ala His His Gly Ala His His Pro Ala Ala Ala 
145                 150                 155                 160 


Ala Ala Tyr Glu Ala Phe Arg Gly Pro Gly Phe Ala Gly Gly Gly Gly 
                165                 170                 175     


Ala Asp Asp Met Gly Ala Gly His His His Gly Ala His His Ala Ala 
            180                 185                 190         


His His His His Ala Ala His His His His His His His His His His 
        195                 200                 205             


Gly Gly Ala Gly His Gly Gly Gly Ala Gly His His Val Arg Leu Glu 
    210                 215                 220                 


Glu Arg Phe Ser Asp Asp Gln Leu Val Ser Met Ser Val Arg Glu Leu 
225                 230                 235                 240 


Asn Arg Gln Leu Arg Gly Phe Ser Lys Glu Glu Val Ile Arg Leu Lys 
                245                 250                 255     


Gln Lys Arg Arg Thr Leu Lys Asn Arg Gly Tyr Ala Gln Ser Cys Arg 
            260                 265                 270         


Phe Lys Arg Val Gln Gln Arg His Ile Leu Glu Ser Glu Lys Cys Gln 
        275                 280                 285             


Leu Gln Ser Gln Val Glu Gln Leu Lys Leu Glu Val Gly Arg Leu Ala 
    290                 295                 300                 


Lys Glu Arg Asp Leu Tyr Lys Glu Lys Tyr Glu Lys Leu Ala Gly Arg 
305                 310                 315                 320 


Gly Gly Pro Gly Ser Ala Gly Gly Ala Gly Phe Pro Arg Glu Pro Ser 
                325                 330                 335     


Pro Pro Gln Ala Gly Pro Gly Gly Ala Lys Gly Thr Ala Asp Phe Phe 
            340                 345                 350         


Leu 
    


<210> 24
<211> 2373
<212> DNA
<213> Homo sapiens

<400> 24
gcgcggccgg gcgcgggccc cgggcgatgg ccgcggagct ggcgatgggc gccgagctgc       60

ccagcagccc gctggccatc gagtacgtca acgacttcga cctgatgaag ttcgaggtga      120

agaaggagcc tcccgaggcc gagcgcttct gccaccgcct gccgccaggc tcgctgtcct      180

cgacgccgct cagcacgccc tgctcctccg tgccctcctc gcccagcttc tgcgcgccca      240

gcccgggcac cggcggcggc ggcggcgcgg ggggcggcgg cggctcgtct caggccgggg      300

gcgcccccgg gccgccgagc gggggccccg gcgccgtcgg gggcacctcg gggaagccgg      360

cgctggagga tctgtactgg atgagcggct accagcatca cctcaacccc gaggcgctca      420

acctgacgcc cgaggacgcg gtggaggcgc tcatcggcag cggccaccac ggcgcgcacc      480

acggcgcgca ccacccggcg gccgccgcag cctacgaggc tttccgcggc ccgggcttcg      540

cgggcggcgg cggagcggac gacatgggcg ccggccacca ccacggcgcg caccacgccg      600

cccaccatca ccacgccgcc caccaccacc accaccacca ccaccaccat ggcggcgcgg      660

gacacggcgg tggcgcgggc caccacgtgc gcctggagga gcgcttctcc gacgaccagc      720

tggtgtccat gtcggtgcgc gagctgaacc ggcagctccg cggcttcagc aaggaggagg      780

tcatccggct caagcagaag cggcgcacgc tcaagaaccg cggctacgcg cagtcctgcc      840

gcttcaagcg ggtgcagcag cggcacattc tggagagcga gaagtgccaa ctccagagcc      900

aggtggagca gctgaagctg gaggtggggc gcctggccaa agagcgggac ctgtacaagg      960

agaaatacga gaagctggcg ggccggggcg gccccgggag cgcgggcggg gccggtttcc     1020

cgcgggagcc ttcgccgccg caggccggtc ccggcggggc caagggcacg gccgacttct     1080

tcctgtaggc gccggacccc gagcccgcgc cgccgtcgcc ggggacaagt tcgcgcaggc     1140

ctctcggggc ctcggctcgg actccgcggt acaggacgtg gacaccaggc ccggcccggc     1200

cgtgctggcc ccggtgccaa gtctgcgggc gcggggctgg aggccccttc gctcccggtc     1260

cccgttcgcg cgcgtcggcc cgggtcgccg tcctgaggtt gagcggagaa cggtgatttc     1320

taaggaaact tgagccaggt ctaacttctt tccaagcgtc cgcttgtaca tacgttgaac     1380

gtggttctcc gttcccacct tcgccctgcc agcctagagg gaccgcgctg ccgtcccttc     1440

ccgggtggcc cctgcctgcc cccgccctcc ttcgttctct tctcagcctc cctttccttg     1500

ccttttttaa cttcccctcc ccgttttaaa atcggtctta ttttcgaagt atttataatt     1560

attatgcttg gtgattagaa aagaaaacct tggaggaagc cccttctttc cccagccggg     1620

gtccgccctc agtcgcgagt cacagcatga gtcgctcgcc aggaggggcc cggcccctgc     1680

ctgccccctc cccgcttgcc cccgaccctg ctaccggcgt tccttggagg tcgaagccag     1740

ggacgtcacc cgtgctgtgt ccaggcctgc tgtcctacta tgctcaaccg ggggtggggg     1800

gaggggggtg agtcctgtgc tcagtcgggt gggggctggc ccggatcccg agctgctgtc     1860

tctctatgca ccagaacata tctgtaactc ctggggaaat acatcttgtt ttaaccttca     1920

agagaagtga aagaaaaaag taatgcacag tatttctagc agaaaatttt tttttttaag     1980

aggaggcttg ggccagagcc ttctggcatg gggcgggtgg agaaagtgtt tttattttaa     2040

tttaaattgt gtttcgtttt gtttgtggaa tctttcttta atgcttcgtc gctctttgga     2100

ctagccggga gagagggcga ggaggcgggt gctccaggcc ctgtaggctg ggccaggcgc     2160

ctgggggatc tgcccgtttt cggaggccct caggggccat cagtgggatt ccagccgctc     2220

cacacccctc ccctgagcac tcggagtgga aggcgcgccg actcgttgaa agttttgttg     2280

tgtagttggt tttcgttgag ttcttttttc atttgctacg aaactgagaa aaagaaaaaa     2340

atacacaaaa taaatctgtt cagatccaag tca                                  2373


<210> 25
<211> 1939
<212> PRT
<213> Homo sapiens

<400> 25
Met Thr Asp Ala Gln Met Ala Asp Phe Gly Ala Ala Ala Gln Tyr Leu 
1               5                   10                  15      


Arg Lys Ser Glu Lys Glu Arg Leu Glu Ala Gln Thr Arg Pro Phe Asp 
            20                  25                  30          


Ile Arg Thr Glu Cys Phe Val Pro Asp Asp Lys Glu Glu Phe Val Lys 
        35                  40                  45              


Ala Lys Ile Leu Ser Arg Glu Gly Gly Lys Val Ile Ala Glu Thr Glu 
    50                  55                  60                  


Asn Gly Lys Thr Val Thr Val Lys Glu Asp Gln Val Leu Gln Gln Asn 
65                  70                  75                  80  


Pro Pro Lys Phe Asp Lys Ile Glu Asp Met Ala Met Leu Thr Phe Leu 
                85                  90                  95      


His Glu Pro Ala Val Leu Phe Asn Leu Lys Glu Arg Tyr Ala Ala Trp 
            100                 105                 110         


Met Ile Tyr Thr Tyr Ser Gly Leu Phe Cys Val Thr Val Asn Pro Tyr 
        115                 120                 125             


Lys Trp Leu Pro Val Tyr Asn Ala Glu Val Val Ala Ala Tyr Arg Gly 
    130                 135                 140                 


Lys Lys Arg Ser Glu Ala Pro Pro His Ile Phe Ser Ile Ser Asp Asn 
145                 150                 155                 160 


Ala Tyr Gln Tyr Met Leu Thr Asp Arg Glu Asn Gln Ser Ile Leu Ile 
                165                 170                 175     


Thr Gly Glu Ser Gly Ala Gly Lys Thr Val Asn Thr Lys Arg Val Ile 
            180                 185                 190         


Gln Tyr Phe Ala Ser Ile Ala Ala Ile Gly Asp Arg Gly Lys Lys Asp 
        195                 200                 205             


Asn Ala Asn Ala Asn Lys Gly Thr Leu Glu Asp Gln Ile Ile Gln Ala 
    210                 215                 220                 


Asn Pro Ala Leu Glu Ala Phe Gly Asn Ala Lys Thr Val Arg Asn Asp 
225                 230                 235                 240 


Asn Ser Ser Arg Phe Gly Lys Phe Ile Arg Ile His Phe Gly Ala Thr 
                245                 250                 255     


Gly Lys Leu Ala Ser Ala Asp Ile Glu Thr Tyr Leu Leu Glu Lys Ser 
            260                 265                 270         


Arg Val Ile Phe Gln Leu Lys Ala Glu Arg Asn Tyr His Ile Phe Tyr 
        275                 280                 285             


Gln Ile Leu Ser Asn Lys Lys Pro Glu Leu Leu Asp Met Leu Leu Val 
    290                 295                 300                 


Thr Asn Asn Pro Tyr Asp Tyr Ala Phe Val Ser Gln Gly Glu Val Ser 
305                 310                 315                 320 


Val Ala Ser Ile Asp Asp Ser Glu Glu Leu Met Ala Thr Asp Ser Ala 
                325                 330                 335     


Phe Asp Val Leu Gly Phe Thr Ser Glu Glu Lys Ala Gly Val Tyr Lys 
            340                 345                 350         


Leu Thr Gly Ala Ile Met His Tyr Gly Asn Met Lys Phe Lys Gln Lys 
        355                 360                 365             


Gln Arg Glu Glu Gln Ala Glu Pro Asp Gly Thr Glu Asp Ala Asp Lys 
    370                 375                 380                 


Ser Ala Tyr Leu Met Gly Leu Asn Ser Ala Asp Leu Leu Lys Gly Leu 
385                 390                 395                 400 


Cys His Pro Arg Val Lys Val Gly Asn Glu Tyr Val Thr Lys Gly Gln 
                405                 410                 415     


Ser Val Gln Gln Val Tyr Tyr Ser Ile Gly Ala Leu Ala Lys Ala Val 
            420                 425                 430         


Tyr Glu Lys Met Phe Asn Trp Met Val Thr Arg Ile Asn Ala Thr Leu 
        435                 440                 445             


Glu Thr Lys Gln Pro Arg Gln Tyr Phe Ile Gly Val Leu Asp Ile Ala 
    450                 455                 460                 


Gly Phe Glu Ile Phe Asp Phe Asn Ser Phe Glu Gln Leu Cys Ile Asn 
465                 470                 475                 480 


Phe Thr Asn Glu Lys Leu Gln Gln Phe Phe Asn His His Met Phe Val 
                485                 490                 495     


Leu Glu Gln Glu Glu Tyr Lys Lys Glu Gly Ile Glu Trp Thr Phe Ile 
            500                 505                 510         


Asp Phe Gly Met Asp Leu Gln Ala Cys Ile Asp Leu Ile Glu Lys Pro 
        515                 520                 525             


Met Gly Ile Met Ser Ile Leu Glu Glu Glu Cys Met Phe Pro Lys Ala 
    530                 535                 540                 


Thr Asp Met Thr Phe Lys Ala Lys Leu Tyr Asp Asn His Leu Gly Lys 
545                 550                 555                 560 


Ser Asn Asn Phe Gln Lys Pro Arg Asn Ile Lys Gly Lys Gln Glu Ala 
                565                 570                 575     


His Phe Ser Leu Ile His Tyr Ala Gly Thr Val Asp Tyr Asn Ile Leu 
            580                 585                 590         


Gly Trp Leu Glu Lys Asn Lys Asp Pro Leu Asn Glu Thr Val Val Ala 
        595                 600                 605             


Leu Tyr Gln Lys Ser Ser Leu Lys Leu Met Ala Thr Leu Phe Ser Ser 
    610                 615                 620                 


Tyr Ala Thr Ala Asp Thr Gly Asp Ser Gly Lys Ser Lys Gly Gly Lys 
625                 630                 635                 640 


Lys Lys Gly Ser Ser Phe Gln Thr Val Ser Ala Leu His Arg Glu Asn 
                645                 650                 655     


Leu Asn Lys Leu Met Thr Asn Leu Arg Thr Thr His Pro His Phe Val 
            660                 665                 670         


Arg Cys Ile Ile Pro Asn Glu Arg Lys Ala Pro Gly Val Met Asp Asn 
        675                 680                 685             


Pro Leu Val Met His Gln Leu Arg Cys Asn Gly Val Leu Glu Gly Ile 
    690                 695                 700                 


Arg Ile Cys Arg Lys Gly Phe Pro Asn Arg Ile Leu Tyr Gly Asp Phe 
705                 710                 715                 720 


Arg Gln Arg Tyr Arg Ile Leu Asn Pro Val Ala Ile Pro Glu Gly Gln 
                725                 730                 735     


Phe Ile Asp Ser Arg Lys Gly Thr Glu Lys Leu Leu Ser Ser Leu Asp 
            740                 745                 750         


Ile Asp His Asn Gln Tyr Lys Phe Gly His Thr Lys Val Phe Phe Lys 
        755                 760                 765             


Ala Gly Leu Leu Gly Leu Leu Glu Glu Met Arg Asp Glu Arg Leu Ser 
    770                 775                 780                 


Arg Ile Ile Thr Arg Met Gln Ala Gln Ala Arg Gly Gln Leu Met Arg 
785                 790                 795                 800 


Ile Glu Phe Lys Lys Ile Val Glu Arg Arg Asp Ala Leu Leu Val Ile 
                805                 810                 815     


Gln Trp Asn Ile Arg Ala Phe Met Gly Val Lys Asn Trp Pro Trp Met 
            820                 825                 830         


Lys Leu Tyr Phe Lys Ile Lys Pro Leu Leu Lys Ser Ala Glu Thr Glu 
        835                 840                 845             


Lys Glu Met Ala Thr Met Lys Glu Glu Phe Gly Arg Ile Lys Glu Thr 
    850                 855                 860                 


Leu Glu Lys Ser Glu Ala Arg Arg Lys Glu Leu Glu Glu Lys Met Val 
865                 870                 875                 880 


Ser Leu Leu Gln Glu Lys Asn Asp Leu Gln Leu Gln Val Gln Ala Glu 
                885                 890                 895     


Gln Asp Asn Leu Asn Asp Ala Glu Glu Arg Cys Asp Gln Leu Ile Lys 
            900                 905                 910         


Asn Lys Ile Gln Leu Glu Ala Lys Val Lys Glu Met Asn Glu Arg Leu 
        915                 920                 925             


Glu Asp Glu Glu Glu Met Asn Ala Glu Leu Thr Ala Lys Lys Arg Lys 
    930                 935                 940                 


Leu Glu Asp Glu Cys Ser Glu Leu Lys Lys Asp Ile Asp Asp Leu Glu 
945                 950                 955                 960 


Leu Thr Leu Ala Lys Val Glu Lys Glu Lys His Ala Thr Glu Asn Lys 
                965                 970                 975     


Val Lys Asn Leu Thr Glu Glu Met Ala Gly Leu Asp Glu Ile Ile Ala 
            980                 985                 990         


Lys Leu Thr Lys Glu Lys Lys Ala  Leu Gln Glu Ala His  Gln Gln Ala 
        995                 1000                 1005             


Leu Asp  Asp Leu Gln Val Glu  Glu Asp Lys Val Asn  Ser Leu Ser 
    1010                 1015                 1020             


Lys Ser  Lys Val Lys Leu Glu  Gln Gln Val Asp Asp  Leu Glu Gly 
    1025                 1030                 1035             


Ser Leu  Glu Gln Glu Lys Lys  Val Arg Met Asp Leu  Glu Arg Ala 
    1040                 1045                 1050             


Lys Arg  Lys Leu Glu Gly Asp  Leu Lys Leu Thr Gln  Glu Ser Ile 
    1055                 1060                 1065             


Met Asp  Leu Glu Asn Asp Lys  Leu Gln Leu Glu Glu  Lys Leu Lys 
    1070                 1075                 1080             


Lys Lys  Glu Phe Asp Ile Asn  Gln Gln Asn Ser Lys  Ile Glu Asp 
    1085                 1090                 1095             


Glu Gln  Val Leu Ala Leu Gln  Leu Gln Lys Lys Leu  Lys Glu Asn 
    1100                 1105                 1110             


Gln Ala  Arg Ile Glu Glu Leu  Glu Glu Glu Leu Glu  Ala Glu Arg 
    1115                 1120                 1125             


Thr Ala  Arg Ala Lys Val Glu  Lys Leu Arg Ser Asp  Leu Ser Arg 
    1130                 1135                 1140             


Glu Leu  Glu Glu Ile Ser Glu  Arg Leu Glu Glu Ala  Gly Gly Ala 
    1145                 1150                 1155             


Thr Ser  Val Gln Ile Glu Met  Asn Lys Lys Arg Glu  Ala Glu Phe 
    1160                 1165                 1170             


Gln Lys  Met Arg Arg Asp Leu  Glu Glu Ala Thr Leu  Gln His Glu 
    1175                 1180                 1185             


Ala Thr  Ala Ala Ala Leu Arg  Lys Lys His Ala Asp  Ser Val Ala 
    1190                 1195                 1200             


Glu Leu  Gly Glu Gln Ile Asp  Asn Leu Gln Arg Val  Lys Gln Lys 
    1205                 1210                 1215             


Leu Glu  Lys Glu Lys Ser Glu  Phe Lys Leu Glu Leu  Asp Asp Val 
    1220                 1225                 1230             


Thr Ser  Asn Met Glu Gln Ile  Ile Lys Ala Lys Ala  Asn Leu Glu 
    1235                 1240                 1245             


Lys Val  Ser Arg Thr Leu Glu  Asp Gln Ala Asn Glu  Tyr Arg Val 
    1250                 1255                 1260             


Lys Leu  Glu Glu Ala Gln Arg  Ser Leu Asn Asp Phe  Thr Thr Gln 
    1265                 1270                 1275             


Arg Ala  Lys Leu Gln Thr Glu  Asn Gly Glu Leu Ala  Arg Gln Leu 
    1280                 1285                 1290             


Glu Glu  Lys Glu Ala Leu Ile  Ser Gln Leu Thr Arg  Gly Lys Leu 
    1295                 1300                 1305             


Ser Tyr  Thr Gln Gln Met Glu  Asp Leu Lys Arg Gln  Leu Glu Glu 
    1310                 1315                 1320             


Glu Gly  Lys Ala Lys Asn Ala  Leu Ala His Ala Leu  Gln Ser Ala 
    1325                 1330                 1335             


Arg His  Asp Cys Asp Leu Leu  Arg Glu Gln Tyr Glu  Glu Glu Thr 
    1340                 1345                 1350             


Glu Ala  Lys Ala Glu Leu Gln  Arg Val Leu Ser Lys  Ala Asn Ser 
    1355                 1360                 1365             


Glu Val  Ala Gln Trp Arg Thr  Lys Tyr Glu Thr Asp  Ala Ile Gln 
    1370                 1375                 1380             


Arg Thr  Glu Glu Leu Glu Glu  Ala Lys Lys Lys Leu  Ala Gln Arg 
    1385                 1390                 1395             


Leu Gln  Asp Ala Glu Glu Ala  Val Glu Ala Val Asn  Ala Lys Cys 
    1400                 1405                 1410             


Ser Ser  Leu Glu Lys Thr Lys  His Arg Leu Gln Asn  Glu Ile Glu 
    1415                 1420                 1425             


Asp Leu  Met Val Asp Val Glu  Arg Ser Asn Ala Ala  Ala Ala Ala 
    1430                 1435                 1440             


Leu Asp  Lys Lys Gln Arg Asn  Phe Asp Lys Ile Leu  Ala Glu Trp 
    1445                 1450                 1455             


Lys Gln  Lys Tyr Glu Glu Ser  Gln Ser Glu Leu Glu  Ser Ser Gln 
    1460                 1465                 1470             


Lys Glu  Ala Arg Ser Leu Ser  Thr Glu Leu Phe Lys  Leu Lys Asn 
    1475                 1480                 1485             


Ala Tyr  Glu Glu Ser Leu Glu  His Leu Glu Thr Phe  Lys Arg Glu 
    1490                 1495                 1500             


Asn Lys  Asn Leu Gln Glu Glu  Ile Ser Asp Leu Thr  Glu Gln Leu 
    1505                 1510                 1515             


Gly Glu  Gly Gly Lys Asn Val  His Glu Leu Glu Lys  Val Arg Lys 
    1520                 1525                 1530             


Gln Leu  Glu Val Glu Lys Leu  Glu Leu Gln Ser Ala  Leu Glu Glu 
    1535                 1540                 1545             


Ala Glu  Ala Ser Leu Glu His  Glu Glu Gly Lys Ile  Leu Arg Ala 
    1550                 1555                 1560             


Gln Leu  Glu Phe Asn Gln Ile  Lys Ala Glu Ile Glu  Arg Lys Leu 
    1565                 1570                 1575             


Ala Glu  Lys Asp Glu Glu Met  Glu Gln Ala Lys Arg  Asn His Gln 
    1580                 1585                 1590             


Arg Val  Val Asp Ser Leu Gln  Thr Ser Leu Asp Ala  Glu Thr Arg 
    1595                 1600                 1605             


Ser Arg  Asn Glu Val Leu Arg  Val Lys Lys Lys Met  Glu Gly Asp 
    1610                 1615                 1620             


Leu Asn  Glu Met Glu Ile Gln  Leu Ser His Ala Asn  Arg Met Ala 
    1625                 1630                 1635             


Ala Glu  Ala Gln Lys Gln Val  Lys Ser Leu Gln Ser  Leu Leu Lys 
    1640                 1645                 1650             


Asp Thr  Gln Ile Gln Leu Asp  Asp Ala Val Arg Ala  Asn Asp Asp 
    1655                 1660                 1665             


Leu Lys  Glu Asn Ile Ala Ile  Val Glu Arg Arg Asn  Asn Leu Leu 
    1670                 1675                 1680             


Gln Ala  Glu Leu Glu Glu Leu  Arg Ala Val Val Glu  Gln Thr Glu 
    1685                 1690                 1695             


Arg Ser  Arg Lys Leu Ala Glu  Gln Glu Leu Ile Glu  Thr Ser Glu 
    1700                 1705                 1710             


Arg Val  Gln Leu Leu His Ser  Gln Asn Thr Ser Leu  Ile Asn Gln 
    1715                 1720                 1725             


Lys Lys  Lys Met Glu Ser Asp  Leu Thr Gln Leu Gln  Ser Glu Val 
    1730                 1735                 1740             


Glu Glu  Ala Val Gln Glu Cys  Arg Asn Ala Glu Glu  Lys Ala Lys 
    1745                 1750                 1755             


Lys Ala  Ile Thr Asp Ala Ala  Met Met Ala Glu Glu  Leu Lys Lys 
    1760                 1765                 1770             


Glu Gln  Asp Thr Ser Ala His  Leu Glu Arg Met Lys  Lys Asn Met 
    1775                 1780                 1785             


Glu Gln  Thr Ile Lys Asp Leu  Gln His Arg Leu Asp  Glu Ala Glu 
    1790                 1795                 1800             


Gln Ile  Ala Leu Lys Gly Gly  Lys Lys Gln Leu Gln  Lys Leu Glu 
    1805                 1810                 1815             


Ala Arg  Val Arg Glu Leu Glu  Gly Glu Leu Glu Ala  Glu Gln Lys 
    1820                 1825                 1830             


Arg Asn  Ala Glu Ser Val Lys  Gly Met Arg Lys Ser  Glu Arg Arg 
    1835                 1840                 1845             


Ile Lys  Glu Leu Thr Tyr Gln  Thr Glu Glu Asp Lys  Lys Asn Leu 
    1850                 1855                 1860             


Leu Arg  Leu Gln Asp Leu Val  Asp Lys Leu Gln Leu  Lys Val Lys 
    1865                 1870                 1875             


Ala Tyr  Lys Arg Gln Ala Glu  Glu Ala Glu Glu Gln  Ala Asn Thr 
    1880                 1885                 1890             


Asn Leu  Ser Lys Phe Arg Lys  Val Gln His Glu Leu  Asp Glu Ala 
    1895                 1900                 1905             


Glu Glu  Arg Ala Asp Ile Ala  Glu Ser Gln Val Asn  Lys Leu Arg 
    1910                 1915                 1920             


Ala Lys  Ser Arg Asp Ile Gly  Ala Lys Gln Lys Met  His Asp Glu 
    1925                 1930                 1935             


Glu 
    


<210> 26
<211> 5941
<212> DNA
<213> Homo sapiens

<400> 26
agatagagag actcctgcgg cccagattct tcaggattct ccgtgaaggg ataaccaggg       60

gaagcaccaa gatgaccgat gcccagatgg ctgactttgg ggcagcggcc cagtacctcc      120

gcaagtcaga gaaggagcgt ctagaggccc agacccggcc ctttgacatt cgcactgagt      180

gcttcgtgcc cgatgacaag gaagagtttg tcaaagccaa gattttgtcc cgggagggag      240

gcaaggtcat tgctgaaacc gagaatggga agacggtgac tgtgaaggag gaccaggtgt      300

tgcagcagaa cccacccaag ttcgacaaga ttgaggacat ggccatgctg accttcctgc      360

acgagcccgc ggtgcttttc aacctcaagg agcgctacgc ggcctggatg atatatacct      420

actcgggcct cttctgtgtc actgtcaacc cctacaagtg gctgccggtg tacaatgccg      480

aggtggtggc cgcctaccgg ggcaagaaga ggagtgaggc cccgccccac atcttctcca      540

tctccgacaa cgcctatcag tacatgctga cagatcggga gaaccagtcc atcctcatca      600

cgggagaatc cggggcgggg aagactgtga acaccaagcg tgtcatccag tactttgcca      660

gcattgcagc cataggtgac cgtggcaaga aggacaatgc caatgcgaac aagggcaccc      720

tggaggacca gatcatccag gccaaccccg ctctggaggc cttcggcaat gccaagactg      780

tccggaacga caactcctcc cgctttggga aattcattag gatccacttt ggggccactg      840

gaaagctggc ttctgcagac atagagacct acctgctgga gaagtcccgg gtgatcttcc      900

agctgaaagc tgagagaaac taccacatct tctaccagat tctgtccaac aagaagccgg      960

agttgctgga catgctgctg gtcaccaaca atccctacga ctacgccttc gtgtctcagg     1020

gagaggtgtc cgtggcctcc attgatgact ccgaggagct catggccacc gatagtgcct     1080

ttgacgtgct gggcttcact tcagaggaga aagctggcgt ctacaagctg acgggagcca     1140

tcatgcacta cgggaacatg aagttcaagc agaagcagcg ggaggagcag gcggagccag     1200

acggcaccga agatgctgac aagtcggcct acctcatggg gctgaactca gctgacctgc     1260

tcaaggggct gtgccaccct cgggtgaaag tgggcaacga gtatgtcacc aaggggcaga     1320

gcgtgcagca ggtgtactac tccatcgggg ctctggccaa ggcagtgtat gagaagatgt     1380

tcaactggat ggtgacgcgc atcaacgcca ccctggagac caagcagcca cgccagtact     1440

tcataggagt cctggacatc gctggcttcg agatcttcga cttcaacagc tttgagcagc     1500

tctgcatcaa cttcaccaac gagaagctgc agcagttctt caaccaccac atgttcgtgc     1560

tggagcagga ggagtacaag aaggagggca ttgagtggac attcattgac tttggcatgg     1620

acctgcaggc ctgcattgac ctcatcgaga agcccatggg catcatgtcc atcctggagg     1680

aggagtgcat gttccccaag gccactgaca tgaccttcaa ggccaagctg tacgacaacc     1740

acctgggcaa gtccaacaat ttccagaagc cacgcaacat caaggggaag caggaagccc     1800

acttctccct gatccactac gccggcactg tggactacaa catcctgggc tggctggaaa     1860

aaaacaagga tcctctcaac gagactgttg tggccctgta ccagaagtcc tccctcaagc     1920

tcatggccac tctcttctcc tcctacgcaa ctgccgatac tggggacagt ggtaaaagca     1980

aaggaggcaa gaaaaagggc tcatccttcc agacggtgtc ggctctccac cgggaaaatc     2040

tcaacaagct aatgaccaac ctgaggacca cccatcctca ctttgtgcgt tgcatcatcc     2100

ccaatgagcg gaaggctcca ggggtgatgg acaaccccct ggtcatgcac cagctgcgct     2160

gcaatggcgt gctggagggc atccgcatct gcaggaaggg cttccccaac cgcatcctct     2220

acggggactt ccggcagagg tatcgcatcc tgaacccagt ggccatccct gagggacagt     2280

tcattgatag caggaagggg acagagaagc tgctcagctc tctggacatt gatcacaacc     2340

agtacaagtt tggccacacc aaggtgttct tcaaggcagg gctgcttggg ctgctggagg     2400

agatgcggga tgagaggctg agccgcatca tcacgcgcat gcaggcccaa gcccggggcc     2460

agctcatgcg cattgagttc aagaagatag tggaacgcag ggatgccctg ctggtaatcc     2520

agtggaacat tcgggccttc atgggggtca agaattggcc ctggatgaag ctctacttca     2580

agatcaagcc gctgctgaag agcgcagaga cggagaagga gatggccacc atgaaggaag     2640

agttcgggcg catcaaagag acgctggaga agtccgaggc tcgccgcaag gagctggagg     2700

agaagatggt gtccctgctg caggagaaga atgacctgca gctccaagtg caggcggaac     2760

aagacaacct caatgatgct gaggagcgct gcgaccagct gatcaaaaac aagattcagc     2820

tggaggccaa agtaaaggag atgaatgaga ggctggagga tgaggaggag atgaacgcgg     2880

agctcactgc caagaagcgc aagctggaag acgagtgctc agagctcaag aaggacattg     2940

atgacctgga gctgacactg gccaaggtgg agaaggagaa gcatgcaaca gagaacaagg     3000

tgaagaacct aacagaggag atggctgggc tggatgaaat catcgctaag ctgaccaagg     3060

agaagaaagc tctacaagag gcccatcagc aggccctgga tgaccttcag gttgaggaag     3120

acaaggtcaa cagcctgtcc aagtctaagg tcaagctgga gcagcaggtg gatgatctgg     3180

agggatccct agagcaagag aagaaggtgc gcatggacct ggagcgagca aagcggaaac     3240

tggagggcga cctgaagctg acccaggaga gcatcatgga cctggaaaat gataaactgc     3300

agctggaaga aaagcttaag aagaaggagt ttgacattaa tcagcagaac agtaagattg     3360

aggatgagca ggtgctggcc cttcaactac agaagaaact gaaggaaaac caggcacgca     3420

tcgaggagct ggaggaggag ctggaggccg agcgcaccgc cagggctaag gtggagaagc     3480

tgcgctcaga cctgtctcgg gagctggagg agatcagcga gcggctggaa gaggccggcg     3540

gggccacgtc cgtgcagatc gagatgaaca agaagcgcga ggccgagttc cagaagatgc     3600

ggcgggacct ggaggaggcc acgctgcagc acgaggccac tgccgcggcc ctgcgcaaga     3660

agcacgccga cagcgtggcc gagctgggcg agcagatcga caacctgcag cgggtgaagc     3720

agaagctgga gaaggagaag agcgagttca agctggagct ggatgacgtc acctccaaca     3780

tggagcagat catcaaggcc aaggcaaacc tggagaaagt gtctcggacg ctggaggacc     3840

aggccaatga gtaccgcgtg aagctagaag aggcccaacg ctccctcaat gatttcacca     3900

cccagcgagc caagctgcag accgagaatg gagagttggc ccggcagcta gaggaaaagg     3960

aggcgctaat ctcgcagctg acccggggga agctctctta tacccagcaa atggaggacc     4020

tcaaaaggca gctggaggag gagggcaagg cgaagaacgc cctggcccat gcactgcagt     4080

cggcccggca tgactgcgac ctgctgcggg agcagtacga ggaggagaca gaggccaagg     4140

ccgagctgca gcgcgtcctg tccaaggcca actcggaggt ggcccagtgg aggaccaagt     4200

atgagacgga cgccattcag cggactgagg agctcgaaga ggccaaaaag aagctggccc     4260

agcggctgca ggatgccgag gaggccgtgg aggctgttaa tgccaagtgc tcctcactgg     4320

agaagaccaa gcaccggcta cagaatgaga tagaggactt gatggtggac gtagagcgct     4380

ccaatgctgc tgctgcagcc ctggacaaga agcagagaaa ctttgacaag atcctggccg     4440

agtggaagca gaagtatgag gagtcgcagt ctgagctgga gtcctcacag aaggaggctc     4500

gctccctcag cacagagctc ttcaagctca agaacgccta cgaggagtcc ctggagcacc     4560

tagagacctt caagcgggag aacaagaacc ttcaggagga aatctcggac cttactgagc     4620

agctaggaga aggaggaaag aatgtgcatg agctggagaa ggtccgcaaa cagctggagg     4680

tggagaagct ggagctgcag tcagccctgg aggaggcaga ggcctccctg gagcacgagg     4740

agggcaagat cctccgggcc cagctagagt tcaaccagat caaggcagag atcgagcgga     4800

agctggcaga gaaggacgag gagatggaac aggccaagcg caaccaccag cgggtggtgg     4860

actcgctgca gacctccctg gatgcagaga cacgcagccg caacgaggtc ctgagggtga     4920

agaagaagat ggaaggagac ctcaatgaga tggagatcca gctcagccac gccaaccgca     4980

tggctgccga ggcccagaag caagtcaaga gcctccagag cttgctgaag gacacccaga     5040

tccagctgga cgatgcggtc cgtgccaacg acgacctgaa ggagaacatc gccatcgtgg     5100

agcggcgcaa caacctgctg caggctgagc tggaggagct gcgtgccgtg gtggagcaga     5160

cagagcggtc ccggaagctg gcggagcagg agctgattga gaccagcgag cgggtgcagc     5220

tgctgcattc ccagaacacc agcctcatca accagaagaa gaagatggag tcggatctga     5280

cccagctcca gtcggaagtg gaggaggcag tgcaggagtg cagaaacgcc gaggagaagg     5340

ccaagaaggc catcacggat gccgccatga tggcagagga gctgaagaag gagcaggaca     5400

ccagcgccca cctggagcgc atgaagaaga acatggagca gaccattaag gacctgcagc     5460

accggctgga cgaggccgag cagatcgccc tcaagggagg caagaagcag ctgcagaagc     5520

tggaagcgcg ggtgcgggag ctggagggtg agctggaggc cgagcagaag cgcaacgcag     5580

agtcggtgaa gggcatgagg aagagcgagc ggcgcatcaa ggagctcacc taccagacag     5640

aggaagacaa aaagaacctg ctgcggctac aggacctggt ggacaagctg caactgaagg     5700

tcaaggccta caagcgccag gccgaggagg cggaggagca agccaacacc aacctgtcca     5760

agttccgcaa ggtgcagcat gagctggatg aggcagagga gcgggcggac atcgctgagt     5820

cccaggtcaa caagcttcga gccaagagcc gtgacattgg tgccaagcaa aaaatgcacg     5880

atgaggagtg acactgcctc gggaacctca ctcttgccaa cctgtaataa atatgagtgc     5940

c                                                                     5941


<210> 27
<211> 175
<212> PRT
<213> Homo sapiens

<400> 27
Met Ala Ser Arg Lys Ala Gly Thr Arg Gly Lys Val Ala Ala Thr Lys 
1               5                   10                  15      


Gln Ala Gln Arg Gly Ser Ser Asn Val Phe Ser Met Phe Glu Gln Ala 
            20                  25                  30          


Gln Ile Gln Glu Phe Lys Glu Ala Phe Ser Cys Ile Asp Gln Asn Arg 
        35                  40                  45              


Asp Gly Ile Ile Cys Lys Ala Asp Leu Arg Glu Thr Tyr Ser Gln Leu 
    50                  55                  60                  


Gly Lys Val Ser Val Pro Glu Glu Glu Leu Asp Ala Met Leu Gln Glu 
65                  70                  75                  80  


Gly Lys Gly Pro Ile Asn Phe Thr Val Phe Leu Thr Leu Phe Gly Glu 
                85                  90                  95      


Lys Leu Asn Gly Thr Asp Pro Glu Glu Ala Ile Leu Ser Ala Phe Arg 
            100                 105                 110         


Met Phe Asp Pro Ser Gly Lys Gly Val Val Asn Lys Asp Glu Phe Lys 
        115                 120                 125             


Gln Leu Leu Leu Thr Gln Ala Asp Lys Phe Ser Pro Ala Glu Val Glu 
    130                 135                 140                 


Gln Met Phe Ala Leu Thr Pro Met Asp Leu Ala Gly Asn Ile Asp Tyr 
145                 150                 155                 160 


Lys Ser Leu Cys Tyr Ile Ile Thr His Gly Asp Glu Lys Glu Glu 
                165                 170                 175 


<210> 28
<211> 619
<212> DNA
<213> Homo sapiens

<400> 28
tctgcagaga gaatggccag caggaaggcg gggacccggg gcaaggtggc agccaccaag       60

caggcccaac gtggttcttc caacgtcttt tccatgtttg aacaagccca gatacaggag      120

ttcaaagaag ccttcagctg tatcgaccag aatcgtgatg gcatcatctg caaggcagac      180

ctgagggaga cctactccca gctggggaag gtgagtgtcc cagaggagga gctggacgcc      240

atgctgcaag agggcaaggg ccccatcaac ttcaccgtct tcctcacgct ctttggggag      300

aagctcaatg ggacagaccc cgaggaagcc atcctgagtg ccttccgcat gtttgacccc      360

agcggcaaag gggtggtgaa caaggatgag ttcaagcagc ttctcctgac ccaggcagac      420

aagttctctc cagctgaggt ggagcagatg ttcgccctga cacccatgga cctggcgggg      480

aacatcgact acaagtcact gtgctacatc atcacccatg gagacgagaa agaggaatga      540

ggggcagggc caggcccacg ggggggcacc tcaataaact ctgttgcaaa attggaaaaa      600

aaaaaaaaaa aaaaaaaaa                                                   619


<210> 29
<211> 5179
<212> PRT
<213> Homo sapiens

<400> 29
Met Gly Leu Pro Leu Ala Arg Leu Ala Ala Val Cys Leu Ala Leu Ser 
1               5                   10                  15      


Leu Ala Gly Gly Ser Glu Leu Gln Thr Glu Gly Arg Thr Arg Asn His 
            20                  25                  30          


Gly His Asn Val Cys Ser Thr Trp Gly Asn Phe His Tyr Lys Thr Phe 
        35                  40                  45              


Asp Gly Asp Val Phe Arg Phe Pro Gly Pro Cys Asp Tyr Asn Phe Ala 
    50                  55                  60                  


Ser Asp Cys Arg Gly Ser Tyr Lys Glu Phe Ala Val His Leu Lys Arg 
65                  70                  75                  80  


Gly Pro Gly Gln Ala Glu Ala Pro Ala Gly Val Glu Ser Ile Leu Leu 
                85                  90                  95      


Thr Ile Lys Asp Asp Thr Ile Tyr Leu Thr Arg His Leu Ala Val Leu 
            100                 105                 110         


Asn Gly Ala Val Val Ser Thr Pro His Tyr Ser Pro Gly Leu Leu Ile 
        115                 120                 125             


Glu Lys Ser Asp Ala Tyr Thr Lys Val Tyr Ser Arg Ala Gly Leu Thr 
    130                 135                 140                 


Leu Met Trp Asn Arg Glu Asp Ala Leu Met Leu Glu Leu Asp Thr Lys 
145                 150                 155                 160 


Phe Arg Asn His Thr Cys Gly Leu Cys Gly Asp Tyr Asn Gly Leu Gln 
                165                 170                 175     


Ser Tyr Ser Glu Phe Leu Ser Asp Gly Val Leu Phe Ser Pro Leu Glu 
            180                 185                 190         


Phe Gly Asn Met Gln Lys Ile Asn Gln Pro Asp Val Val Cys Glu Asp 
        195                 200                 205             


Pro Glu Glu Glu Val Ala Pro Ala Ser Cys Ser Glu His Arg Ala Glu 
    210                 215                 220                 


Cys Glu Arg Leu Leu Thr Ala Glu Ala Phe Ala Asp Cys Gln Asp Leu 
225                 230                 235                 240 


Val Pro Leu Glu Pro Tyr Leu Arg Ala Cys Gln Gln Asp Arg Cys Arg 
                245                 250                 255     


Cys Pro Gly Gly Asp Thr Cys Val Cys Ser Thr Val Ala Glu Phe Ser 
            260                 265                 270         


Arg Gln Cys Ser His Ala Gly Gly Arg Pro Gly Asn Trp Arg Thr Ala 
        275                 280                 285             


Thr Leu Cys Pro Lys Thr Cys Pro Gly Asn Leu Val Tyr Leu Glu Ser 
    290                 295                 300                 


Gly Ser Pro Cys Met Asp Thr Cys Ser His Leu Glu Val Ser Ser Leu 
305                 310                 315                 320 


Cys Glu Glu His Arg Met Asp Gly Cys Phe Cys Pro Glu Gly Thr Val 
                325                 330                 335     


Tyr Asp Asp Ile Gly Asp Ser Gly Cys Val Pro Val Ser Gln Cys His 
            340                 345                 350         


Cys Arg Leu His Gly His Leu Tyr Thr Pro Gly Gln Glu Ile Thr Asn 
        355                 360                 365             


Asp Cys Glu Gln Cys Val Cys Asn Ala Gly Arg Trp Val Cys Lys Asp 
    370                 375                 380                 


Leu Pro Cys Pro Gly Thr Cys Ala Leu Glu Gly Gly Ser His Ile Thr 
385                 390                 395                 400 


Thr Phe Asp Gly Lys Thr Tyr Thr Phe His Gly Asp Cys Tyr Tyr Val 
                405                 410                 415     


Leu Ala Lys Gly Asp His Asn Asp Ser Tyr Ala Leu Leu Gly Glu Leu 
            420                 425                 430         


Ala Pro Cys Gly Ser Thr Asp Lys Gln Thr Cys Leu Lys Thr Val Val 
        435                 440                 445             


Leu Leu Ala Asp Lys Lys Lys Asn Val Val Val Phe Lys Ser Asp Gly 
    450                 455                 460                 


Ser Val Leu Leu Asn Glu Leu Gln Val Asn Leu Pro His Val Thr Ala 
465                 470                 475                 480 


Ser Phe Ser Val Phe Arg Pro Ser Ser Tyr His Ile Met Val Ser Met 
                485                 490                 495     


Ala Ile Gly Val Arg Leu Gln Val Gln Leu Ala Pro Val Met Gln Leu 
            500                 505                 510         


Phe Val Thr Leu Asp Gln Ala Ser Gln Gly Gln Val Gln Gly Leu Cys 
        515                 520                 525             


Gly Asn Phe Asn Gly Leu Glu Gly Asp Asp Phe Lys Thr Ala Ser Gly 
    530                 535                 540                 


Leu Val Glu Ala Thr Gly Ala Gly Phe Ala Asn Thr Trp Lys Ala Gln 
545                 550                 555                 560 


Ser Thr Cys His Asp Lys Leu Asp Trp Leu Asp Asp Pro Cys Ser Leu 
                565                 570                 575     


Asn Ile Glu Ser Ala Asn Tyr Ala Glu His Trp Cys Ser Leu Leu Lys 
            580                 585                 590         


Lys Thr Glu Thr Pro Phe Gly Arg Cys His Ser Ala Val Asp Pro Ala 
        595                 600                 605             


Glu Tyr Tyr Lys Arg Cys Lys Tyr Asp Thr Cys Asn Cys Gln Asn Asn 
    610                 615                 620                 


Glu Asp Cys Leu Cys Ala Ala Leu Ser Ser Tyr Ala Arg Ala Cys Thr 
625                 630                 635                 640 


Ala Lys Gly Val Met Leu Trp Gly Trp Arg Glu His Val Cys Asn Lys 
                645                 650                 655     


Asp Val Gly Ser Cys Pro Asn Ser Gln Val Phe Leu Tyr Asn Leu Thr 
            660                 665                 670         


Thr Cys Gln Gln Thr Cys Arg Ser Leu Ser Glu Ala Asp Ser His Cys 
        675                 680                 685             


Leu Glu Gly Phe Ala Pro Val Asp Gly Cys Gly Cys Pro Asp His Thr 
    690                 695                 700                 


Phe Leu Asp Glu Lys Gly Arg Cys Val Pro Leu Ala Lys Cys Ser Cys 
705                 710                 715                 720 


Tyr His Arg Gly Leu Tyr Leu Glu Ala Gly Asp Val Val Val Arg Gln 
                725                 730                 735     


Glu Glu Arg Cys Val Cys Arg Asp Gly Arg Leu His Cys Arg Gln Ile 
            740                 745                 750         


Arg Leu Ile Gly Gln Ser Cys Thr Ala Pro Lys Ile His Met Asp Cys 
        755                 760                 765             


Ser Asn Leu Thr Ala Leu Ala Thr Ser Lys Pro Arg Ala Leu Ser Cys 
    770                 775                 780                 


Gln Thr Leu Ala Ala Gly Tyr Tyr His Thr Glu Cys Val Ser Gly Cys 
785                 790                 795                 800 


Val Cys Pro Asp Gly Leu Met Asp Asp Gly Arg Gly Gly Cys Val Val 
                805                 810                 815     


Glu Lys Glu Cys Pro Cys Val His Asn Asn Asp Leu Tyr Ser Ser Gly 
            820                 825                 830         


Ala Lys Ile Lys Val Asp Cys Asn Thr Cys Thr Cys Lys Arg Gly Arg 
        835                 840                 845             


Trp Val Cys Thr Gln Ala Val Cys His Gly Thr Cys Ser Ile Tyr Gly 
    850                 855                 860                 


Ser Gly His Tyr Ile Thr Phe Asp Gly Lys Tyr Tyr Asp Phe Asp Gly 
865                 870                 875                 880 


His Cys Ser Tyr Val Ala Val Gln Asp Tyr Cys Gly Gln Asn Ser Ser 
                885                 890                 895     


Leu Gly Ser Phe Ser Ile Ile Thr Glu Asn Val Pro Cys Gly Thr Thr 
            900                 905                 910         


Gly Val Thr Cys Ser Lys Ala Ile Lys Ile Phe Met Gly Arg Thr Glu 
        915                 920                 925             


Leu Lys Leu Glu Asp Lys His Arg Val Val Ile Gln Arg Asp Glu Gly 
    930                 935                 940                 


His His Val Ala Tyr Thr Thr Arg Glu Val Gly Gln Tyr Leu Val Val 
945                 950                 955                 960 


Glu Ser Ser Thr Gly Ile Ile Val Ile Trp Asp Lys Arg Thr Thr Val 
                965                 970                 975     


Phe Ile Lys Leu Ala Pro Ser Tyr Lys Gly Thr Val Cys Gly Leu Cys 
            980                 985                 990         


Gly Asn Phe Asp His Arg Ser Asn  Asn Asp Phe Thr Thr  Arg Asp His 
        995                 1000                 1005             


Met Val  Val Ser Ser Glu Leu  Asp Phe Gly Asn Ser  Trp Lys Glu 
    1010                 1015                 1020             


Ala Pro  Thr Cys Pro Asp Val  Ser Thr Asn Pro Glu  Pro Cys Ser 
    1025                 1030                 1035             


Leu Asn  Pro His Arg Arg Ser  Trp Ala Glu Lys Gln  Cys Ser Ile 
    1040                 1045                 1050             


Leu Lys  Ser Ser Val Phe Ser  Ile Cys His Ser Lys  Val Asp Pro 
    1055                 1060                 1065             


Lys Pro  Phe Tyr Glu Ala Cys  Val His Asp Ser Cys  Ser Cys Asp 
    1070                 1075                 1080             


Thr Gly  Gly Asp Cys Glu Cys  Phe Cys Ser Ala Val  Ala Ser Tyr 
    1085                 1090                 1095             


Ala Gln  Glu Cys Thr Lys Glu  Gly Ala Cys Val Phe  Trp Arg Thr 
    1100                 1105                 1110             


Pro Asp  Leu Cys Pro Ile Phe  Cys Asp Tyr Tyr Asn  Pro Pro His 
    1115                 1120                 1125             


Glu Cys  Glu Trp His Tyr Glu  Pro Cys Gly Asn Arg  Ser Phe Glu 
    1130                 1135                 1140             


Thr Cys  Arg Thr Ile Asn Gly  Ile His Ser Asn Ile  Ser Val Ser 
    1145                 1150                 1155             


Tyr Leu  Glu Gly Cys Tyr Pro  Arg Cys Pro Lys Asp  Arg Pro Ile 
    1160                 1165                 1170             


Tyr Glu  Glu Asp Leu Lys Lys  Cys Val Thr Ala Asp  Lys Cys Gly 
    1175                 1180                 1185             


Cys Tyr  Val Glu Asp Thr His  Tyr Pro Pro Gly Ala  Ser Val Pro 
    1190                 1195                 1200             


Thr Glu  Glu Thr Cys Lys Ser  Cys Val Cys Thr Asn  Ser Ser Gln 
    1205                 1210                 1215             


Val Val  Cys Arg Pro Glu Glu  Gly Lys Ile Leu Asn  Gln Thr Gln 
    1220                 1225                 1230             


Asp Gly  Ala Phe Cys Tyr Trp  Glu Ile Cys Gly Pro  Asn Gly Thr 
    1235                 1240                 1245             


Val Glu  Lys His Phe Asn Ile  Cys Ser Ile Thr Thr  Arg Pro Ser 
    1250                 1255                 1260             


Thr Leu  Thr Thr Phe Thr Thr  Ile Thr Leu Pro Thr  Thr Pro Thr 
    1265                 1270                 1275             


Thr Phe  Thr Thr Thr Thr Thr  Thr Thr Thr Pro Thr  Ser Ser Thr 
    1280                 1285                 1290             


Val Leu  Ser Thr Thr Pro Lys  Leu Cys Cys Leu Trp  Ser Asp Trp 
    1295                 1300                 1305             


Ile Asn  Glu Asp His Pro Ser  Ser Gly Ser Asp Asp  Gly Asp Arg 
    1310                 1315                 1320             


Glu Thr  Phe Asp Gly Val Cys  Gly Ala Pro Glu Asp  Ile Glu Cys 
    1325                 1330                 1335             


Arg Ser  Val Lys Asp Pro His  Leu Ser Leu Glu Gln  Leu Gly Gln 
    1340                 1345                 1350             


Lys Val  Gln Cys Asp Val Ser  Val Gly Phe Ile Cys  Lys Asn Glu 
    1355                 1360                 1365             


Asp Gln  Phe Gly Asn Gly Pro  Phe Gly Leu Cys Tyr  Asp Tyr Lys 
    1370                 1375                 1380             


Ile Arg  Val Asn Cys Cys Trp  Pro Met Asp Lys Cys  Ile Thr Thr 
    1385                 1390                 1395             


Pro Ser  Pro Pro Thr Thr Thr  Pro Ser Pro Pro Pro  Thr Ser Thr 
    1400                 1405                 1410             


Thr Thr  Leu Pro Pro Thr Thr  Thr Pro Ser Pro Pro  Thr Thr Thr 
    1415                 1420                 1425             


Thr Thr  Thr Pro Pro Pro Thr  Thr Thr Pro Ser Pro  Pro Ile Thr 
    1430                 1435                 1440             


Thr Thr  Thr Thr Pro Pro Pro  Thr Thr Thr Pro Ser  Pro Pro Ile 
    1445                 1450                 1455             


Ser Thr  Thr Thr Thr Pro Pro  Pro Thr Thr Thr Pro  Ser Pro Pro 
    1460                 1465                 1470             


Thr Thr  Thr Pro Ser Pro Pro  Thr Thr Thr Pro Ser  Pro Pro Thr 
    1475                 1480                 1485             


Thr Thr  Thr Thr Thr Pro Pro  Pro Thr Thr Thr Pro  Ser Pro Pro 
    1490                 1495                 1500             


Thr Thr  Thr Pro Ile Thr Pro  Pro Ala Ser Thr Thr  Thr Leu Pro 
    1505                 1510                 1515             


Pro Thr  Thr Thr Pro Ser Pro  Pro Thr Thr Thr Thr  Thr Thr Pro 
    1520                 1525                 1530             


Pro Pro  Thr Thr Thr Pro Ser  Pro Pro Thr Thr Thr  Pro Ile Thr 
    1535                 1540                 1545             


Pro Pro  Thr Ser Thr Thr Thr  Leu Pro Pro Thr Thr  Thr Pro Ser 
    1550                 1555                 1560             


Pro Pro  Pro Thr Thr Thr Thr  Thr Pro Pro Pro Thr  Thr Thr Pro 
    1565                 1570                 1575             


Ser Pro  Pro Thr Thr Thr Thr  Pro Ser Pro Pro Thr  Ile Thr Thr 
    1580                 1585                 1590             


Thr Thr  Pro Pro Pro Thr Thr  Thr Pro Ser Pro Pro  Thr Thr Thr 
    1595                 1600                 1605             


Thr Thr  Thr Pro Pro Pro Thr  Thr Thr Pro Ser Pro  Pro Thr Thr 
    1610                 1615                 1620             


Thr Pro  Ile Thr Pro Pro Thr  Ser Thr Thr Thr Leu  Pro Pro Thr 
    1625                 1630                 1635             


Thr Thr  Pro Ser Pro Pro Pro  Thr Thr Thr Thr Thr  Pro Pro Pro 
    1640                 1645                 1650             


Thr Thr  Thr Pro Ser Pro Pro  Thr Thr Thr Thr Pro  Ser Pro Pro 
    1655                 1660                 1665             


Ile Thr  Thr Thr Thr Thr Pro  Pro Pro Thr Thr Thr  Pro Ser Ser 
    1670                 1675                 1680             


Pro Ile  Thr Thr Thr Pro Ser  Pro Pro Thr Thr Thr  Met Thr Thr 
    1685                 1690                 1695             


Pro Ser  Pro Thr Thr Thr Pro  Ser Ser Pro Ile Thr  Thr Thr Thr 
    1700                 1705                 1710             


Thr Pro  Ser Ser Thr Thr Thr  Pro Ser Pro Pro Pro  Thr Thr Met 
    1715                 1720                 1725             


Thr Thr  Pro Ser Pro Thr Thr  Thr Pro Ser Pro Pro  Thr Thr Thr 
    1730                 1735                 1740             


Met Thr  Thr Leu Pro Pro Thr  Thr Thr Ser Ser Pro  Leu Thr Thr 
    1745                 1750                 1755             


Thr Pro  Leu Pro Pro Ser Ile  Thr Pro Pro Thr Phe  Ser Pro Phe 
    1760                 1765                 1770             


Ser Thr  Thr Thr Pro Thr Thr  Pro Cys Val Pro Leu  Cys Asn Trp 
    1775                 1780                 1785             


Thr Gly  Trp Leu Asp Ser Gly  Lys Pro Asn Phe His  Lys Pro Gly 
    1790                 1795                 1800             


Gly Asp  Thr Glu Leu Ile Gly  Asp Val Cys Gly Pro  Gly Trp Ala 
    1805                 1810                 1815             


Ala Asn  Ile Ser Cys Arg Ala  Thr Met Tyr Pro Asp  Val Pro Ile 
    1820                 1825                 1830             


Gly Gln  Leu Gly Gln Thr Val  Val Cys Asp Val Ser  Val Gly Leu 
    1835                 1840                 1845             


Ile Cys  Lys Asn Glu Asp Gln  Lys Pro Gly Gly Val  Ile Pro Met 
    1850                 1855                 1860             


Ala Phe  Cys Leu Asn Tyr Glu  Ile Asn Val Gln Cys  Cys Glu Cys 
    1865                 1870                 1875             


Val Thr  Gln Pro Thr Thr Met  Thr Thr Thr Thr Thr  Glu Asn Pro 
    1880                 1885                 1890             


Thr Pro  Pro Thr Thr Thr Pro  Ile Thr Thr Thr Thr  Thr Val Thr 
    1895                 1900                 1905             


Pro Thr  Pro Thr Pro Thr Gly  Thr Gln Thr Pro Thr  Thr Thr Pro 
    1910                 1915                 1920             


Ile Thr  Thr Thr Thr Thr Val  Thr Pro Thr Pro Thr  Pro Thr Gly 
    1925                 1930                 1935             


Thr Gln  Thr Pro Thr Thr Thr  Pro Ile Thr Thr Thr  Thr Thr Val 
    1940                 1945                 1950             


Thr Pro  Thr Pro Thr Pro Thr  Gly Thr Gln Thr Pro  Thr Thr Thr 
    1955                 1960                 1965             


Pro Ile  Thr Thr Thr Thr Thr  Val Thr Pro Thr Pro  Thr Pro Thr 
    1970                 1975                 1980             


Gly Thr  Gln Thr Pro Thr Thr  Thr Pro Ile Thr Thr  Thr Thr Thr 
    1985                 1990                 1995             


Val Thr  Pro Thr Pro Thr Pro  Thr Gly Thr Gln Thr  Pro Thr Thr 
    2000                 2005                 2010             


Thr Pro  Ile Thr Thr Thr Thr  Thr Val Thr Pro Thr  Pro Thr Pro 
    2015                 2020                 2025             


Thr Gly  Thr Gln Thr Pro Thr  Thr Thr Pro Ile Thr  Thr Thr Thr 
    2030                 2035                 2040             


Thr Val  Thr Pro Thr Pro Thr  Pro Thr Gly Thr Gln  Thr Pro Thr 
    2045                 2050                 2055             


Thr Thr  Pro Ile Thr Thr Thr  Thr Thr Val Thr Pro  Thr Pro Thr 
    2060                 2065                 2070             


Pro Thr  Gly Thr Gln Thr Pro  Thr Thr Thr Pro Ile  Thr Thr Thr 
    2075                 2080                 2085             


Thr Thr  Val Thr Pro Thr Pro  Thr Pro Thr Gly Thr  Gln Thr Pro 
    2090                 2095                 2100             


Thr Thr  Thr Pro Ile Thr Thr  Thr Thr Thr Val Thr  Pro Thr Pro 
    2105                 2110                 2115             


Thr Pro  Thr Gly Thr Gln Thr  Pro Thr Thr Thr Pro  Ile Thr Thr 
    2120                 2125                 2130             


Thr Thr  Thr Val Thr Pro Thr  Pro Thr Pro Thr Gly  Thr Gln Thr 
    2135                 2140                 2145             


Pro Thr  Thr Thr Pro Ile Thr  Thr Thr Thr Thr Val  Thr Pro Thr 
    2150                 2155                 2160             


Pro Thr  Pro Thr Gly Thr Gln  Thr Pro Thr Thr Thr  Pro Ile Thr 
    2165                 2170                 2175             


Thr Thr  Thr Thr Val Thr Pro  Thr Pro Thr Pro Thr  Gly Thr Gln 
    2180                 2185                 2190             


Thr Pro  Thr Thr Thr Pro Ile  Thr Thr Thr Thr Thr  Val Thr Pro 
    2195                 2200                 2205             


Thr Pro  Thr Pro Thr Gly Thr  Gln Thr Pro Thr Thr  Thr Pro Ile 
    2210                 2215                 2220             


Thr Thr  Thr Thr Thr Val Thr  Pro Thr Pro Thr Pro  Thr Gly Thr 
    2225                 2230                 2235             


Gln Thr  Pro Thr Thr Thr Pro  Ile Thr Thr Thr Thr  Thr Val Thr 
    2240                 2245                 2250             


Pro Thr  Pro Thr Pro Thr Gly  Thr Gln Thr Pro Thr  Thr Thr Pro 
    2255                 2260                 2265             


Ile Thr  Thr Thr Thr Thr Val  Thr Pro Thr Pro Thr  Pro Thr Gly 
    2270                 2275                 2280             


Thr Gln  Thr Pro Thr Thr Thr  Pro Ile Thr Thr Thr  Thr Thr Val 
    2285                 2290                 2295             


Thr Pro  Thr Pro Thr Pro Thr  Gly Thr Gln Thr Pro  Thr Thr Thr 
    2300                 2305                 2310             


Pro Ile  Thr Thr Thr Thr Thr  Val Thr Pro Thr Pro  Thr Pro Thr 
    2315                 2320                 2325             


Gly Thr  Gln Thr Pro Thr Thr  Thr Pro Ile Thr Thr  Thr Thr Thr 
    2330                 2335                 2340             


Val Thr  Pro Thr Pro Thr Pro  Thr Gly Thr Gln Thr  Pro Thr Thr 
    2345                 2350                 2355             


Thr Pro  Ile Thr Thr Thr Thr  Thr Val Thr Pro Thr  Pro Thr Pro 
    2360                 2365                 2370             


Thr Gly  Thr Gln Thr Pro Thr  Thr Thr Pro Ile Thr  Thr Thr Thr 
    2375                 2380                 2385             


Thr Val  Thr Pro Thr Pro Thr  Pro Thr Gly Thr Gln  Thr Pro Thr 
    2390                 2395                 2400             


Thr Thr  Pro Ile Thr Thr Thr  Thr Thr Val Thr Pro  Thr Pro Thr 
    2405                 2410                 2415             


Pro Thr  Gly Thr Gln Thr Pro  Thr Thr Thr Pro Ile  Thr Thr Thr 
    2420                 2425                 2430             


Thr Thr  Val Thr Pro Thr Pro  Thr Pro Thr Gly Thr  Gln Thr Pro 
    2435                 2440                 2445             


Thr Thr  Thr Pro Ile Thr Thr  Thr Thr Thr Val Thr  Pro Thr Pro 
    2450                 2455                 2460             


Thr Pro  Thr Gly Thr Gln Thr  Pro Thr Thr Thr Pro  Ile Thr Thr 
    2465                 2470                 2475             


Thr Thr  Thr Val Thr Pro Thr  Pro Thr Pro Thr Gly  Thr Gln Thr 
    2480                 2485                 2490             


Pro Thr  Thr Thr Pro Ile Thr  Thr Thr Thr Thr Val  Thr Pro Thr 
    2495                 2500                 2505             


Pro Thr  Pro Thr Gly Thr Gln  Thr Pro Thr Thr Thr  Pro Ile Thr 
    2510                 2515                 2520             


Thr Thr  Thr Thr Val Thr Pro  Thr Pro Thr Pro Thr  Gly Thr Gln 
    2525                 2530                 2535             


Thr Pro  Thr Thr Thr Pro Ile  Thr Thr Thr Thr Thr  Val Thr Pro 
    2540                 2545                 2550             


Thr Pro  Thr Pro Thr Gly Thr  Gln Thr Pro Thr Thr  Thr Pro Ile 
    2555                 2560                 2565             


Thr Thr  Thr Thr Thr Val Thr  Pro Thr Pro Thr Pro  Thr Gly Thr 
    2570                 2575                 2580             


Gln Thr  Pro Thr Thr Thr Pro  Ile Thr Thr Thr Thr  Thr Val Thr 
    2585                 2590                 2595             


Pro Thr  Pro Thr Pro Thr Gly  Thr Gln Thr Pro Thr  Thr Thr Pro 
    2600                 2605                 2610             


Ile Thr  Thr Thr Thr Thr Val  Thr Pro Thr Pro Thr  Pro Thr Gly 
    2615                 2620                 2625             


Thr Gln  Thr Pro Thr Thr Thr  Pro Ile Thr Thr Thr  Thr Thr Val 
    2630                 2635                 2640             


Thr Pro  Thr Pro Thr Pro Thr  Gly Thr Gln Thr Pro  Thr Thr Thr 
    2645                 2650                 2655             


Pro Ile  Thr Thr Thr Thr Thr  Val Thr Pro Thr Pro  Thr Pro Thr 
    2660                 2665                 2670             


Gly Thr  Gln Thr Pro Thr Thr  Thr Pro Ile Thr Thr  Thr Thr Thr 
    2675                 2680                 2685             


Val Thr  Pro Thr Pro Thr Pro  Thr Gly Thr Gln Thr  Pro Thr Thr 
    2690                 2695                 2700             


Thr Pro  Ile Thr Thr Thr Thr  Thr Val Thr Pro Thr  Pro Thr Pro 
    2705                 2710                 2715             


Thr Gly  Thr Gln Thr Pro Thr  Thr Thr Pro Ile Thr  Thr Thr Thr 
    2720                 2725                 2730             


Thr Val  Thr Pro Thr Pro Thr  Pro Thr Gly Thr Gln  Thr Pro Thr 
    2735                 2740                 2745             


Thr Thr  Pro Ile Thr Thr Thr  Thr Thr Val Thr Pro  Thr Pro Thr 
    2750                 2755                 2760             


Pro Thr  Gly Thr Gln Thr Pro  Thr Thr Thr Pro Ile  Thr Thr Thr 
    2765                 2770                 2775             


Thr Thr  Val Thr Pro Thr Pro  Thr Pro Thr Gly Thr  Gln Thr Pro 
    2780                 2785                 2790             


Thr Thr  Thr Pro Ile Thr Thr  Thr Thr Thr Val Thr  Pro Thr Pro 
    2795                 2800                 2805             


Thr Pro  Thr Gly Thr Gln Thr  Pro Thr Thr Thr Pro  Ile Thr Thr 
    2810                 2815                 2820             


Thr Thr  Thr Val Thr Pro Thr  Pro Thr Pro Thr Gly  Thr Gln Thr 
    2825                 2830                 2835             


Pro Thr  Thr Thr Pro Ile Thr  Thr Thr Thr Thr Val  Thr Pro Thr 
    2840                 2845                 2850             


Pro Thr  Pro Thr Gly Thr Gln  Thr Pro Thr Thr Thr  Pro Ile Thr 
    2855                 2860                 2865             


Thr Thr  Thr Thr Val Thr Pro  Thr Pro Thr Pro Thr  Gly Thr Gln 
    2870                 2875                 2880             


Thr Pro  Thr Thr Thr Pro Ile  Thr Thr Thr Thr Thr  Val Thr Pro 
    2885                 2890                 2895             


Thr Pro  Thr Pro Thr Gly Thr  Gln Thr Pro Thr Thr  Thr Pro Ile 
    2900                 2905                 2910             


Thr Thr  Thr Thr Thr Val Thr  Pro Thr Pro Thr Pro  Thr Gly Thr 
    2915                 2920                 2925             


Gln Thr  Pro Thr Thr Thr Pro  Ile Thr Thr Thr Thr  Thr Val Thr 
    2930                 2935                 2940             


Pro Thr  Pro Thr Pro Thr Gly  Thr Gln Thr Pro Thr  Thr Thr Pro 
    2945                 2950                 2955             


Ile Thr  Thr Thr Thr Thr Val  Thr Pro Thr Pro Thr  Pro Thr Gly 
    2960                 2965                 2970             


Thr Gln  Thr Pro Thr Thr Thr  Pro Ile Thr Thr Thr  Thr Thr Val 
    2975                 2980                 2985             


Thr Pro  Thr Pro Thr Pro Thr  Gly Thr Gln Thr Pro  Thr Thr Thr 
    2990                 2995                 3000             


Pro Ile  Thr Thr Thr Thr Thr  Val Thr Pro Thr Pro  Thr Pro Thr 
    3005                 3010                 3015             


Gly Thr  Gln Thr Pro Thr Thr  Thr Pro Ile Thr Thr  Thr Thr Thr 
    3020                 3025                 3030             


Val Thr  Pro Thr Pro Thr Pro  Thr Gly Thr Gln Thr  Pro Thr Thr 
    3035                 3040                 3045             


Thr Pro  Ile Thr Thr Thr Thr  Thr Val Thr Pro Thr  Pro Thr Pro 
    3050                 3055                 3060             


Thr Gly  Thr Gln Thr Pro Thr  Thr Thr Pro Ile Thr  Thr Thr Thr 
    3065                 3070                 3075             


Thr Val  Thr Pro Thr Pro Thr  Pro Thr Gly Thr Gln  Thr Pro Thr 
    3080                 3085                 3090             


Thr Thr  Pro Ile Thr Thr Thr  Thr Thr Val Thr Pro  Thr Pro Thr 
    3095                 3100                 3105             


Pro Thr  Gly Thr Gln Thr Pro  Thr Thr Thr Pro Ile  Thr Thr Thr 
    3110                 3115                 3120             


Thr Thr  Val Thr Pro Thr Pro  Thr Pro Thr Gly Thr  Gln Thr Pro 
    3125                 3130                 3135             


Thr Thr  Thr Pro Ile Thr Thr  Thr Thr Thr Val Thr  Pro Thr Pro 
    3140                 3145                 3150             


Thr Pro  Thr Gly Thr Gln Thr  Pro Thr Thr Thr Pro  Ile Thr Thr 
    3155                 3160                 3165             


Thr Thr  Thr Val Thr Pro Thr  Pro Thr Pro Thr Gly  Thr Gln Thr 
    3170                 3175                 3180             


Pro Thr  Thr Thr Pro Ile Thr  Thr Thr Thr Thr Val  Thr Pro Thr 
    3185                 3190                 3195             


Pro Thr  Pro Thr Gly Thr Gln  Thr Pro Thr Thr Thr  Pro Ile Thr 
    3200                 3205                 3210             


Thr Thr  Thr Thr Val Thr Pro  Thr Pro Thr Pro Thr  Gly Thr Gln 
    3215                 3220                 3225             


Thr Pro  Thr Thr Thr Pro Ile  Thr Thr Thr Thr Thr  Val Thr Pro 
    3230                 3235                 3240             


Thr Pro  Thr Pro Thr Gly Thr  Gln Thr Pro Thr Thr  Thr Pro Ile 
    3245                 3250                 3255             


Thr Thr  Thr Thr Thr Val Thr  Pro Thr Pro Thr Pro  Thr Gly Thr 
    3260                 3265                 3270             


Gln Thr  Pro Thr Thr Thr Pro  Ile Thr Thr Thr Thr  Thr Val Thr 
    3275                 3280                 3285             


Pro Thr  Pro Thr Pro Thr Gly  Thr Gln Thr Pro Thr  Thr Thr Pro 
    3290                 3295                 3300             


Ile Thr  Thr Thr Thr Thr Val  Thr Pro Thr Pro Thr  Pro Thr Gly 
    3305                 3310                 3315             


Thr Gln  Thr Pro Thr Thr Thr  Pro Ile Thr Thr Thr  Thr Thr Val 
    3320                 3325                 3330             


Thr Pro  Thr Pro Thr Pro Thr  Gly Thr Gln Thr Pro  Thr Thr Thr 
    3335                 3340                 3345             


Pro Ile  Thr Thr Thr Thr Thr  Val Thr Pro Thr Pro  Thr Pro Thr 
    3350                 3355                 3360             


Gly Thr  Gln Thr Pro Thr Thr  Thr Pro Ile Thr Thr  Thr Thr Thr 
    3365                 3370                 3375             


Val Thr  Pro Thr Pro Thr Pro  Thr Gly Thr Gln Thr  Pro Thr Thr 
    3380                 3385                 3390             


Thr Pro  Ile Thr Thr Thr Thr  Thr Val Thr Pro Thr  Pro Thr Pro 
    3395                 3400                 3405             


Thr Gly  Thr Gln Thr Pro Thr  Thr Thr Pro Ile Thr  Thr Thr Thr 
    3410                 3415                 3420             


Thr Val  Thr Pro Thr Pro Thr  Pro Thr Gly Thr Gln  Thr Pro Thr 
    3425                 3430                 3435             


Thr Thr  Pro Ile Thr Thr Thr  Thr Thr Val Thr Pro  Thr Pro Thr 
    3440                 3445                 3450             


Pro Thr  Gly Thr Gln Thr Pro  Thr Thr Thr Pro Ile  Thr Thr Thr 
    3455                 3460                 3465             


Thr Thr  Val Thr Pro Thr Pro  Thr Pro Thr Gly Thr  Gln Thr Pro 
    3470                 3475                 3480             


Thr Thr  Thr Pro Ile Thr Thr  Thr Thr Thr Val Thr  Pro Thr Pro 
    3485                 3490                 3495             


Thr Pro  Thr Gly Thr Gln Thr  Pro Thr Thr Thr Pro  Ile Thr Thr 
    3500                 3505                 3510             


Thr Thr  Thr Val Thr Pro Thr  Pro Thr Pro Thr Gly  Thr Gln Thr 
    3515                 3520                 3525             


Pro Thr  Thr Thr Pro Ile Thr  Thr Thr Thr Thr Val  Thr Pro Thr 
    3530                 3535                 3540             


Pro Thr  Pro Thr Gly Thr Gln  Thr Pro Thr Thr Thr  Pro Ile Thr 
    3545                 3550                 3555             


Thr Thr  Thr Thr Val Thr Pro  Thr Pro Thr Pro Thr  Gly Thr Gln 
    3560                 3565                 3570             


Thr Pro  Thr Thr Thr Pro Ile  Thr Thr Thr Thr Thr  Val Thr Pro 
    3575                 3580                 3585             


Thr Pro  Thr Pro Thr Gly Thr  Gln Thr Pro Thr Thr  Thr Pro Ile 
    3590                 3595                 3600             


Thr Thr  Thr Thr Thr Val Thr  Pro Thr Pro Thr Pro  Thr Gly Thr 
    3605                 3610                 3615             


Gln Thr  Pro Thr Thr Thr Pro  Ile Thr Thr Thr Thr  Thr Val Thr 
    3620                 3625                 3630             


Pro Thr  Pro Thr Pro Thr Gly  Thr Gln Thr Pro Thr  Thr Thr Pro 
    3635                 3640                 3645             


Ile Thr  Thr Thr Thr Thr Val  Thr Pro Thr Pro Thr  Pro Thr Gly 
    3650                 3655                 3660             


Thr Gln  Thr Pro Thr Thr Thr  Pro Ile Thr Thr Thr  Thr Thr Val 
    3665                 3670                 3675             


Thr Pro  Thr Pro Thr Pro Thr  Gly Thr Gln Thr Pro  Thr Thr Thr 
    3680                 3685                 3690             


Pro Ile  Thr Thr Thr Thr Thr  Val Thr Pro Thr Pro  Thr Pro Thr 
    3695                 3700                 3705             


Gly Thr  Gln Thr Pro Thr Thr  Thr Pro Ile Thr Thr  Thr Thr Thr 
    3710                 3715                 3720             


Val Thr  Pro Thr Pro Thr Pro  Thr Gly Thr Gln Thr  Pro Thr Thr 
    3725                 3730                 3735             


Thr Pro  Ile Thr Thr Thr Thr  Thr Val Thr Pro Thr  Pro Thr Pro 
    3740                 3745                 3750             


Thr Gly  Thr Gln Thr Pro Thr  Thr Thr Pro Ile Thr  Thr Thr Thr 
    3755                 3760                 3765             


Thr Val  Thr Pro Thr Pro Thr  Pro Thr Gly Thr Gln  Thr Pro Thr 
    3770                 3775                 3780             


Thr Thr  Pro Ile Thr Thr Thr  Thr Thr Val Thr Pro  Thr Pro Thr 
    3785                 3790                 3795             


Pro Thr  Gly Thr Gln Thr Pro  Thr Thr Thr Pro Ile  Thr Thr Thr 
    3800                 3805                 3810             


Thr Thr  Val Thr Pro Thr Pro  Thr Pro Thr Gly Thr  Gln Thr Pro 
    3815                 3820                 3825             


Thr Thr  Thr Pro Ile Thr Thr  Thr Thr Thr Val Thr  Pro Thr Pro 
    3830                 3835                 3840             


Thr Pro  Thr Gly Thr Gln Thr  Pro Thr Thr Thr Pro  Ile Thr Thr 
    3845                 3850                 3855             


Thr Thr  Thr Val Thr Pro Thr  Pro Thr Pro Thr Gly  Thr Gln Thr 
    3860                 3865                 3870             


Pro Thr  Thr Thr Pro Ile Thr  Thr Thr Thr Thr Val  Thr Pro Thr 
    3875                 3880                 3885             


Pro Thr  Pro Thr Gly Thr Gln  Thr Pro Thr Thr Thr  Pro Ile Thr 
    3890                 3895                 3900             


Thr Thr  Thr Thr Val Thr Pro  Thr Pro Thr Pro Thr  Gly Thr Gln 
    3905                 3910                 3915             


Thr Pro  Thr Thr Thr Pro Ile  Thr Thr Thr Thr Thr  Val Thr Pro 
    3920                 3925                 3930             


Thr Pro  Thr Pro Thr Gly Thr  Gln Thr Pro Thr Thr  Thr Pro Ile 
    3935                 3940                 3945             


Thr Thr  Thr Thr Thr Val Thr  Pro Thr Pro Thr Pro  Thr Gly Thr 
    3950                 3955                 3960             


Gln Thr  Pro Thr Thr Thr Pro  Ile Thr Thr Thr Thr  Thr Val Thr 
    3965                 3970                 3975             


Pro Thr  Pro Thr Pro Thr Gly  Thr Gln Thr Pro Thr  Thr Thr Pro 
    3980                 3985                 3990             


Ile Thr  Thr Thr Thr Thr Val  Thr Pro Thr Pro Thr  Pro Thr Gly 
    3995                 4000                 4005             


Thr Gln  Thr Pro Thr Thr Thr  Pro Ile Thr Thr Thr  Thr Thr Val 
    4010                 4015                 4020             


Thr Pro  Thr Pro Thr Pro Thr  Gly Thr Gln Thr Pro  Thr Thr Thr 
    4025                 4030                 4035             


Pro Ile  Thr Thr Thr Thr Thr  Val Thr Pro Thr Pro  Thr Pro Thr 
    4040                 4045                 4050             


Gly Thr  Gln Thr Pro Thr Thr  Thr Pro Ile Thr Thr  Thr Thr Thr 
    4055                 4060                 4065             


Val Thr  Pro Thr Pro Thr Pro  Thr Gly Thr Gln Thr  Pro Thr Thr 
    4070                 4075                 4080             


Thr Pro  Ile Thr Thr Thr Thr  Thr Val Thr Pro Thr  Pro Thr Pro 
    4085                 4090                 4095             


Thr Gly  Thr Gln Thr Pro Thr  Thr Thr Pro Ile Thr  Thr Thr Thr 
    4100                 4105                 4110             


Thr Val  Thr Pro Thr Pro Thr  Pro Thr Gly Thr Gln  Thr Pro Thr 
    4115                 4120                 4125             


Thr Thr  Pro Ile Thr Thr Thr  Thr Thr Val Thr Pro  Thr Pro Thr 
    4130                 4135                 4140             


Pro Thr  Gly Thr Gln Thr Pro  Thr Thr Thr Pro Ile  Thr Thr Thr 
    4145                 4150                 4155             


Thr Thr  Val Thr Pro Thr Pro  Thr Pro Thr Gly Thr  Gln Thr Pro 
    4160                 4165                 4170             


Thr Thr  Thr Pro Ile Thr Thr  Thr Thr Thr Val Thr  Pro Thr Pro 
    4175                 4180                 4185             


Thr Pro  Thr Gly Thr Gln Thr  Gly Pro Pro Thr His  Thr Ser Thr 
    4190                 4195                 4200             


Ala Pro  Ile Ala Glu Leu Thr  Thr Ser Asn Pro Pro  Pro Glu Ser 
    4205                 4210                 4215             


Ser Thr  Pro Gln Thr Ser Arg  Ser Thr Ser Ser Pro  Leu Thr Glu 
    4220                 4225                 4230             


Ser Thr  Thr Leu Leu Ser Thr  Leu Pro Pro Ala Ile  Glu Met Thr 
    4235                 4240                 4245             


Ser Thr  Ala Pro Pro Ser Thr  Pro Thr Ala Pro Thr  Thr Thr Ser 
    4250                 4255                 4260             


Gly Gly  His Thr Leu Ser Pro  Pro Pro Ser Thr Thr  Thr Ser Pro 
    4265                 4270                 4275             


Pro Gly  Thr Pro Thr Arg Gly  Thr Thr Thr Gly Ser  Ser Ser Ala 
    4280                 4285                 4290             


Pro Thr  Pro Ser Thr Val Gln  Thr Thr Thr Thr Ser  Ala Trp Thr 
    4295                 4300                 4305             


Pro Thr  Pro Thr Pro Leu Ser  Thr Pro Ser Ile Ile  Arg Thr Thr 
    4310                 4315                 4320             


Gly Leu  Arg Pro Tyr Pro Ser  Ser Val Leu Ile Cys  Cys Val Leu 
    4325                 4330                 4335             


Asn Asp  Thr Tyr Tyr Ala Pro  Gly Glu Glu Val Tyr  Asn Gly Thr 
    4340                 4345                 4350             


Tyr Gly  Asp Thr Cys Tyr Phe  Val Asn Cys Ser Leu  Ser Cys Thr 
    4355                 4360                 4365             


Leu Glu  Phe Tyr Asn Trp Ser  Cys Pro Ser Thr Pro  Ser Pro Thr 
    4370                 4375                 4380             


Pro Thr  Pro Ser Lys Ser Thr  Pro Thr Pro Ser Lys  Pro Ser Ser 
    4385                 4390                 4395             


Thr Pro  Ser Lys Pro Thr Pro  Gly Thr Lys Pro Pro  Glu Cys Pro 
    4400                 4405                 4410             


Asp Phe  Asp Pro Pro Arg Gln  Glu Asn Glu Thr Trp  Trp Leu Cys 
    4415                 4420                 4425             


Asp Cys  Phe Met Ala Thr Cys  Lys Tyr Asn Asn Thr  Val Glu Ile 
    4430                 4435                 4440             


Val Lys  Val Glu Cys Glu Pro  Pro Pro Met Pro Thr  Cys Ser Asn 
    4445                 4450                 4455             


Gly Leu  Gln Pro Val Arg Val  Glu Asp Pro Asp Gly  Cys Cys Trp 
    4460                 4465                 4470             


His Trp  Glu Cys Asp Cys Tyr  Cys Thr Gly Trp Gly  Asp Pro His 
    4475                 4480                 4485             


Tyr Val  Thr Phe Asp Gly Leu  Tyr Tyr Ser Tyr Gln  Gly Asn Cys 
    4490                 4495                 4500             


Thr Tyr  Val Leu Val Glu Glu  Ile Ser Pro Ser Val  Asp Asn Phe 
    4505                 4510                 4515             


Gly Val  Tyr Ile Asp Asn Tyr  His Cys Asp Pro Asn  Asp Lys Val 
    4520                 4525                 4530             


Ser Cys  Pro Arg Thr Leu Ile  Val Arg His Glu Thr  Gln Glu Val 
    4535                 4540                 4545             


Leu Ile  Lys Thr Val His Met  Met Pro Met Gln Val  Gln Val Gln 
    4550                 4555                 4560             


Val Asn  Arg Gln Ala Val Ala  Leu Pro Tyr Lys Lys  Tyr Gly Leu 
    4565                 4570                 4575             


Glu Val  Tyr Gln Ser Gly Ile  Asn Tyr Val Val Asp  Ile Pro Glu 
    4580                 4585                 4590             


Leu Gly  Val Leu Val Ser Tyr  Asn Gly Leu Ser Phe  Ser Val Arg 
    4595                 4600                 4605             


Leu Pro  Tyr His Arg Phe Gly  Asn Asn Thr Lys Gly  Gln Cys Gly 
    4610                 4615                 4620             


Thr Cys  Thr Asn Thr Thr Ser  Asp Asp Cys Ile Leu  Pro Ser Gly 
    4625                 4630                 4635             


Glu Ile  Val Ser Asn Cys Glu  Ala Ala Ala Asp Gln  Trp Leu Val 
    4640                 4645                 4650             


Asn Asp  Pro Ser Lys Pro His  Cys Pro His Ser Ser  Ser Thr Thr 
    4655                 4660                 4665             


Lys Arg  Pro Ala Val Thr Val  Pro Gly Gly Gly Lys  Thr Thr Pro 
    4670                 4675                 4680             


His Lys  Asp Cys Thr Pro Ser  Pro Leu Cys Gln Leu  Ile Lys Asp 
    4685                 4690                 4695             


Ser Leu  Phe Ala Gln Cys His  Ala Leu Val Pro Pro  Gln His Tyr 
    4700                 4705                 4710             


Tyr Asp  Ala Cys Val Phe Asp  Ser Cys Phe Met Pro  Gly Ser Ser 
    4715                 4720                 4725             


Leu Glu  Cys Ala Ser Leu Gln  Ala Tyr Ala Ala Leu  Cys Ala Gln 
    4730                 4735                 4740             


Gln Asn  Ile Cys Leu Asp Trp  Arg Asn His Thr His  Gly Ala Cys 
    4745                 4750                 4755             


Leu Val  Glu Cys Pro Ser His  Arg Glu Tyr Gln Ala  Cys Gly Pro 
    4760                 4765                 4770             


Ala Glu  Glu Pro Thr Cys Lys  Ser Ser Ser Ser Gln  Gln Asn Asn 
    4775                 4780                 4785             


Thr Val  Leu Val Glu Gly Cys  Phe Cys Pro Glu Gly  Thr Met Asn 
    4790                 4795                 4800             


Tyr Ala  Pro Gly Phe Asp Val  Cys Val Lys Thr Cys  Gly Cys Val 
    4805                 4810                 4815             


Gly Pro  Asp Asn Val Pro Arg  Glu Phe Gly Glu His  Phe Glu Phe 
    4820                 4825                 4830             


Asp Cys  Lys Asn Cys Val Cys  Leu Glu Gly Gly Ser  Gly Ile Ile 
    4835                 4840                 4845             


Cys Gln  Pro Lys Arg Cys Ser  Gln Lys Pro Val Thr  His Cys Val 
    4850                 4855                 4860             


Glu Asp  Gly Thr Tyr Leu Ala  Thr Glu Val Asn Pro  Ala Asp Thr 
    4865                 4870                 4875             


Cys Cys  Asn Ile Thr Val Cys  Lys Cys Asn Thr Ser  Leu Cys Lys 
    4880                 4885                 4890             


Glu Lys  Pro Ser Val Cys Pro  Leu Gly Phe Glu Val  Lys Ser Lys 
    4895                 4900                 4905             


Met Val  Pro Gly Arg Cys Cys  Pro Phe Tyr Trp Cys  Glu Ser Lys 
    4910                 4915                 4920             


Gly Val  Cys Val His Gly Asn  Ala Glu Tyr Gln Pro  Gly Ser Pro 
    4925                 4930                 4935             


Val Tyr  Ser Ser Lys Cys Gln  Asp Cys Val Cys Thr  Asp Lys Val 
    4940                 4945                 4950             


Asp Asn  Asn Thr Leu Leu Asn  Val Ile Ala Cys Thr  His Val Pro 
    4955                 4960                 4965             


Cys Asn  Thr Ser Cys Ser Pro  Gly Phe Glu Leu Met  Glu Ala Pro 
    4970                 4975                 4980             


Gly Glu  Cys Cys Lys Lys Cys  Glu Gln Thr His Cys  Ile Ile Lys 
    4985                 4990                 4995             


Arg Pro  Asp Asn Gln His Val  Ile Leu Lys Pro Gly  Asp Phe Lys 
    5000                 5005                 5010             


Ser Asp  Pro Lys Asn Asn Cys  Thr Phe Phe Ser Cys  Val Lys Ile 
    5015                 5020                 5025             


His Asn  Gln Leu Ile Ser Ser  Val Ser Asn Ile Thr  Cys Pro Asn 
    5030                 5035                 5040             


Phe Asp  Ala Ser Ile Cys Ile  Pro Gly Ser Ile Thr  Phe Met Pro 
    5045                 5050                 5055             


Asn Gly  Cys Cys Lys Thr Cys  Thr Pro Arg Asn Glu  Thr Arg Val 
    5060                 5065                 5070             


Pro Cys  Ser Thr Val Pro Val  Thr Thr Glu Val Ser  Tyr Ala Gly 
    5075                 5080                 5085             


Cys Thr  Lys Thr Val Leu Met  Asn His Cys Ser Gly  Ser Cys Gly 
    5090                 5095                 5100             


Thr Phe  Val Met Tyr Ser Ala  Lys Ala Gln Ala Leu  Asp His Ser 
    5105                 5110                 5115             


Cys Ser  Cys Cys Lys Glu Glu  Lys Thr Ser Gln Arg  Glu Val Val 
    5120                 5125                 5130             


Leu Ser  Cys Pro Asn Gly Gly  Ser Leu Thr His Thr  Tyr Thr His 
    5135                 5140                 5145             


Ile Glu  Ser Cys Gln Cys Gln  Asp Thr Val Cys Gly  Leu Pro Thr 
    5150                 5155                 5160             


Gly Thr  Ser Arg Arg Ala Arg  Arg Ser Pro Arg His  Leu Gly Ser 
    5165                 5170                 5175             


Gly 
    


<210> 30
<211> 15720
<212> DNA
<213> Homo sapiens

<400> 30
caacccacac cgcccctgcc agccaccatg gggctgccac tagcccgcct ggcggctgtg       60

tgcctggccc tgtctttggc agggggctcg gagctccaga cagagggcag aacccgaaac      120

cacggccaca acgtctgcag cacctggggc aacttccact acaagacctt cgacggggac      180

gtcttccgct tccccggccc ctgcgactac aacttcgcct ccgactgccg aggctcctac      240

aaggaatttg ctgtgcacct gaagcggggt ccgggccagg ctgaggcccc cgccggggtg      300

gagtccatcc tgctgaccat caaggatgac accatctacc tcacccgcca cctggctgtg      360

cttaacgggg ccgtggtcag caccccgcac tacagccccg ggctgctcat tgagaagagc      420

gatgcctaca ccaaagtcta ctcccgcgcc ggcctcaccc tcatgtggaa ccgggaggat      480

gcactcatgc tggagctgga cactaagttc cggaaccaca cctgtggcct ctgcggggac      540

tacaacggcc tgcagagcta ttcagaattc ctctctgacg gcgtgctctt cagtcccctg      600

gagtttggga acatgcagaa gatcaaccag cccgatgtgg tgtgtgagga tcccgaggag      660

gaggtggccc ccgcatcctg ctccgagcac cgcgccgagt gtgagaggct gctgaccgcc      720

gaggccttcg cggactgtca ggacctggtg ccgctggagc cgtatctgcg cgcctgccag      780

caggaccgct gccggtgccc gggcggtgac acctgcgtct gcagcaccgt ggccgagttc      840

tcccgccagt gctcccacgc cggcggccgg cccgggaact ggaggaccgc cacgctctgc      900

cccaagacct gccccgggaa cctggtgtac ctggagagcg gctcgccctg catggacacc      960

tgctcacacc tggaggtgag cagcctgtgc gaggagcacc gcatggacgg ctgtttctgc     1020

ccagaaggca ccgtatatga cgacatcggg gacagtggct gcgttcctgt gagccagtgc     1080

cactgcaggc tgcacggaca cctgtacaca ccgggccagg agatcaccaa tgactgcgag     1140

cagtgtgtct gtaacgctgg ccgctgggtg tgcaaagacc tgccctgccc cggcacctgt     1200

gccctggaag gcggctccca catcaccacc ttcgatggga agacgtacac cttccacggg     1260

gactgctact atgtcctggc caagggtgac cacaacgatt cctacgctct cctgggcgag     1320

ctggccccct gtggctccac agacaagcag acctgcctga agacggtggt gctgctggct     1380

gacaagaaga agaatgtggt ggtcttcaag tccgatggca gtgtactgct caacgagctg     1440

caggtgaacc tgccccacgt gaccgcgagc ttctctgtct tccgcccgtc ttcctaccac     1500

atcatggtga gcatggccat tggcgtccgg ctgcaggtgc agctggcccc agtcatgcaa     1560

ctctttgtga cactggacca ggcctcccag gggcaggtgc agggcctctg cgggaacttc     1620

aacggcctgg aaggtgacga cttcaagacg gccagcgggc tggtggaggc cacgggggcc     1680

ggctttgcca acacctggaa ggcacagtca acctgccatg acaagctgga ctggttggac     1740

gatccctgct ccctgaacat cgagagcgcc aactacgccg agcactggtg ctccctcctg     1800

aagaagacag agaccccctt tggcaggtgc cactcggctg tggaccctgc tgagtattac     1860

aagaggtgca aatatgacac gtgtaactgt cagaacaatg aggactgcct gtgcgccgcc     1920

ctgtcctcct acgcgcgcgc ctgcaccgcc aagggcgtca tgctgtgggg ctggcgggag     1980

catgtctgca acaaggatgt gggctcctgc cccaactcgc aggtcttcct gtacaacctg     2040

accacctgcc agcagacctg ccgctccctc tccgaggccg acagccactg tctcgagggc     2100

tttgcgcctg tggacggctg cggctgccct gaccacacct tcctggacga gaagggccgc     2160

tgcgtacccc tggccaagtg ctcctgttac caccgcggtc tctacctgga ggcgggggac     2220

gtggtcgtca ggcaggaaga acgatgtgtg tgccgggatg ggcggctgca ctgtaggcag     2280

atccggctga tcggccagag ctgcacggcc ccaaagatcc acatggactg cagcaacctg     2340

actgcactgg ccacctcgaa gccccgagcc ctcagctgcc agacgctggc cgccggctat     2400

taccacacag agtgtgtcag tggctgtgtg tgccccgacg ggctgatgga tgacggccgg     2460

ggtggctgcg tggtggagaa ggaatgccct tgcgtccata acaacgacct gtattcttcc     2520

ggcgccaaga tcaaggtgga ctgcaatacc tgcacctgca agagaggacg ctgggtgtgc     2580

acccaggctg tgtgccatgg cacctgctcc atttacggga gtggccacta catcaccttt     2640

gacgggaagt actacgactt tgacggacac tgctcctacg tggctgttca ggactactgc     2700

ggccagaact cctcactggg ctcattcagc atcatcaccg agaacgtccc ctgtggcact     2760

acgggcgtca cctgctccaa ggccatcaag atcttcatgg ggaggacgga gctgaagttg     2820

gaagacaagc accgtgtggt gatccagcgt gatgagggtc accacgtggc ctacaccacg     2880

cgggaggtgg gccagtacct ggtggtggag tccagcacgg gcatcatcgt catctgggac     2940

aagaggacca ccgtgttcat caagctggct ccctcctaca agggcaccgt gtgtggcctg     3000

tgtgggaact ttgaccaccg ctccaacaac gacttcacca cgcgggacca catggtggtg     3060

agcagcgagc tggacttcgg gaacagctgg aaggaggccc ccacctgccc agatgtgagc     3120

accaaccccg agccctgcag cctgaacccg caccgccgct cctgggccga gaagcagtgc     3180

agcatcctca aaagcagcgt gttcagcatc tgccacagca aggtggaccc caagcccttc     3240

tacgaggcct gtgtgcacga ctcgtgctcc tgtgacacgg gtggggactg tgagtgcttc     3300

tgctctgccg tggcctccta cgcccaggag tgtaccaaag agggggcctg cgtgttctgg     3360

aggacgccgg acctgtgccc catattctgc gactactaca accctccgca tgagtgtgag     3420

tggcactatg agccatgtgg gaaccggagc ttcgagacct gcaggaccat caatggcatc     3480

cactccaaca tctccgtgtc ctacctggag ggctgctacc cccggtgccc caaggacagg     3540

cccatctatg aggaggatct gaagaagtgt gtcactgcag acaagtgtgg ctgctatgtc     3600

gaggacaccc actacccacc tggagcatcg gttcccaccg aggagacctg caagtcctgc     3660

gtgtgtacca actcctccca agtcgtctgc aggccggagg aaggaaagat tcttaaccag     3720

acccaggatg gcgccttctg ctactgggag atctgtggcc ccaacgggac ggtggagaag     3780

cacttcaaca tctgttccat tacgacacgc ccgtccaccc tgaccacctt caccaccatc     3840

accctcccca ccacccccac caccttcacc actaccacca ccaccaccac cccgacctcc     3900

agcacagttt tatcaacaac tccgaagctg tgctgcctct ggtctgactg gatcaatgag     3960

gaccacccca gcagtggcag cgacgacggt gaccgagaaa catttgatgg ggtctgcggg     4020

gcccctgagg acatcgagtg caggtcggtc aaggatcccc acctcagctt ggagcagcta     4080

ggccagaagg tgcagtgtga tgtctctgtt gggttcattt gcaagaatga agaccagttt     4140

ggaaatggac catttggact gtgttacgac tacaagatac gtgtcaattg ttgctggccc     4200

atggataagt gtatcaccac tcccagccct ccaactacca ctcccagccc tccaccaacc     4260

agcacgacca cccttccacc aaccaccacc cccagccctc caaccaccac cacaaccacc     4320

cctccaccaa ccaccacccc cagccctcca ataaccacca cgaccacccc tccaccaacc     4380

accactccca gccctccaat aagcaccaca accacccctc caccaaccac cactcccagc     4440

cctccaacca ccactcccag ccctccaacc accactccca gccctccaac aaccaccaca     4500

accacccctc caccaaccac cactcccagc cctccaacga ctacgcccat cactccacca     4560

gccagcacta ccacccttcc accaaccacc actcccagcc ctccaacaac caccacaacc     4620

acccctccac caaccaccac tcccagtcct ccaacgacta cgcccatcac tccaccaacc     4680

agcactacta cccttccacc aaccaccact cccagccctc caccaaccac cacaaccacc     4740

cctccaccaa ccaccactcc cagccctcca acaaccacca ctcccagtcc tccaacaatc     4800

accacaacca cccctccacc aaccaccact cccagccctc caacaacgac cacaaccacc     4860

cctccaccaa ccaccactcc cagccctcca acgactacac ccatcactcc accaaccagc     4920

actaccaccc ttccaccaac caccactccc agccctccac caaccaccac aaccacccct     4980

ccaccaacca ccactcccag ccctccaaca accaccactc ccagccctcc aataaccacc     5040

acaaccaccc ctccaccaac caccactccc agctctccaa taaccaccac tcccagccct     5100

ccaacaacca ccatgaccac cccttcacca accaccaccc ccagctctcc aataaccacc     5160

acaaccaccc cttcctcaac taccactccc agccctccac caaccaccat gaccacccct     5220

tcaccaacca ccactcccag ccctccaaca accaccatga ccacccttcc accaaccacc     5280

acttccagcc ctctaacaac tactcctcta cctccatcaa taactcctcc tacattttca     5340

ccattctcaa cgacaacccc tactacccca tgcgtgcctc tctgcaattg gactggctgg     5400

ctggattctg gaaaacccaa ctttcacaaa ccaggtggag acacagaatt gattggagac     5460

gtctgtggac caggctgggc agctaacatc tcttgcagag ccaccatgta tcctgatgtt     5520

cccattggac agcttggaca aacagtggtg tgtgatgtct ctgtggggct gatatgcaaa     5580

aatgaagacc aaaagccagg tggggtcatc cctatggcct tctgcctcaa ctacgagatc     5640

aacgttcagt gctgtgagtg tgtcacccaa cccaccacca tgacaaccac caccacagag     5700

aacccaactc cgccaaccac gacacccatc accaccacca ctacggtgac cccaacccca     5760

acacccaccg gcacacagac cccaaccacg acacccatca ccaccaccac tacggtgacc     5820

ccaaccccaa cacccaccgg cacacagacc ccaaccacga cacccatcac caccaccact     5880

acggtgaccc caaccccaac acccaccggc acacagaccc caaccacgac acccatcacc     5940

accaccacta cggtgacccc aaccccaaca cccaccggca cacagacccc aaccacgaca     6000

cccatcacca ccaccactac ggtgacccca accccaacac ccaccggcac acagacccca     6060

accacgacac ccatcaccac caccactacg gtgaccccaa ccccaacacc caccggcaca     6120

cagaccccaa ccacgacacc catcaccacc accactacgg tgaccccaac cccaacaccc     6180

accggcacac agaccccaac cacgacaccc atcaccacca ccactacggt gaccccaacc     6240

ccaacaccca ccggcacaca gaccccaacc acgacaccca tcaccaccac cactacggtg     6300

accccaaccc caacacccac cggcacacag accccaacca cgacacccat caccaccacc     6360

actacggtga ccccaacccc aacacccacc ggcacacaga ccccaaccac gacacccatc     6420

accaccacca ctacggtgac cccaacccca acacccaccg gcacacagac cccaaccacg     6480

acacccatca ccaccaccac tacggtgacc ccaaccccaa cacccaccgg cacacagacc     6540

ccaaccacga cacccatcac caccaccact acggtgaccc caaccccaac acccaccggc     6600

acacagaccc caaccacgac acccatcacc accaccacta cggtgacccc aaccccaaca     6660

cccaccggca cacagacccc aaccacgaca cccatcacca ccaccactac ggtgacccca     6720

accccaacac ccaccggcac acagacccca accacgacac ccatcaccac caccactacg     6780

gtgaccccaa ccccaacacc caccggcaca cagaccccaa ccacgacacc catcaccacc     6840

accactacgg tgaccccaac cccaacaccc accggcacac agaccccaac cacgacaccc     6900

atcaccacca ccactacggt gaccccaacc ccaacaccca ccggcacaca gaccccaacc     6960

acgacaccca tcaccaccac cactacggtg accccaaccc caacacccac cggcacacag     7020

accccaacca cgacacccat caccaccacc actacggtga ccccaacccc aacacccacc     7080

ggcacacaga ccccaaccac gacacccatc accaccacca ctacggtgac cccaacccca     7140

acacccaccg gcacacagac cccaaccacg acacccatca ccaccaccac tacggtgacc     7200

ccaaccccaa cacccaccgg cacacagacc ccaaccacga cacccatcac caccaccact     7260

acggtgaccc caaccccaac acccaccggc acacagaccc caaccacgac acccatcacc     7320

accaccacta cggtgacccc aaccccaaca cccaccggca cacagacccc aaccacgaca     7380

cccatcacca ccaccactac ggtgacccca accccaacac ccaccggcac acagacccca     7440

accacgacac ccatcaccac caccactacg gtgaccccaa ccccaacacc caccggcaca     7500

cagaccccaa ccacgacacc catcaccacc accactacgg tgaccccaac cccaacaccc     7560

accggcacac agaccccaac cacgacaccc atcaccacca ccactacggt gaccccaacc     7620

ccaacaccca ccggcacaca gaccccaacc acgacaccca tcaccaccac cactacggtg     7680

accccaaccc caacacccac cggcacacag accccaacca cgacacccat caccaccacc     7740

actacggtga ccccaacccc aacacccacc ggcacacaga ccccaaccac gacacccatc     7800

accaccacca ctacggtgac cccaacccca acacccaccg gcacacagac cccaaccacg     7860

acacccatca ccaccaccac tacggtgacc ccaaccccaa cacccaccgg cacacagacc     7920

ccaaccacga cacccatcac caccaccact acggtgaccc caaccccaac acccaccggc     7980

acacagaccc caaccacgac acccatcacc accaccacta cggtgacccc aaccccaaca     8040

cccaccggca cacagacccc aaccacgaca cccatcacca ccaccactac ggtgacccca     8100

accccaacac ccaccggcac acagacccca accacgacac ccatcaccac caccactacg     8160

gtgaccccaa ccccaacacc caccggcaca cagaccccaa ccacgacacc catcaccacc     8220

accactacgg tgaccccaac cccaacaccc accggcacac agaccccaac cacgacaccc     8280

atcaccacca ccactacggt gaccccaacc ccaacaccca ccggcacaca gaccccaacc     8340

acgacaccca tcaccaccac cactacggtg accccaaccc caacacccac cggcacacag     8400

accccaacca cgacacccat caccaccacc actacggtga ccccaacccc aacacccacc     8460

ggcacacaga ccccaaccac gacacccatc accaccacca ctacggtgac cccaacccca     8520

acacccaccg gcacacagac cccaaccacg acacccatca ccaccaccac tacggtgacc     8580

ccaaccccaa cacccaccgg cacacagacc ccaaccacga cacccatcac caccaccact     8640

acggtgaccc caaccccaac acccaccggc acacagaccc caaccacgac acccatcacc     8700

accaccacta cggtgacccc aaccccaaca cccaccggca cacagacccc aaccacgaca     8760

cccatcacca ccaccactac ggtgacccca accccaacac ccaccggcac acagacccca     8820

accacgacac ccatcaccac caccactacg gtgaccccaa ccccaacacc caccggcaca     8880

cagaccccaa ccacgacacc catcaccacc accactacgg tgaccccaac cccaacaccc     8940

accggcacac agaccccaac cacgacaccc atcaccacca ccactacggt gaccccaacc     9000

ccaacaccca ccggcacaca gaccccaacc acgacaccca tcaccaccac cactacggtg     9060

accccaaccc caacacccac cggcacacag accccaacca cgacacccat caccaccacc     9120

actacggtga ccccaacccc aacacccacc ggcacacaga ccccaaccac gacacccatc     9180

accaccacca ctacggtgac cccaacccca acacccaccg gcacacagac cccaaccacg     9240

acacccatca ccaccaccac tacggtgacc ccaaccccaa cacccaccgg cacacagacc     9300

ccaaccacga cacccatcac caccaccact acggtgaccc caaccccaac acccaccggc     9360

acacagaccc caaccacgac acccatcacc accaccacta cggtgacccc aaccccaaca     9420

cccaccggca cacagacccc aaccacgaca cccatcacca ccaccactac ggtgacccca     9480

accccaacac ccaccggcac acagacccca accacgacac ccatcaccac caccactacg     9540

gtgaccccaa ccccaacacc caccggcaca cagaccccaa ccacgacacc catcaccacc     9600

accactacgg tgaccccaac cccaacaccc accggcacac agaccccaac cacgacaccc     9660

atcaccacca ccactacggt gaccccaacc ccaacaccca ccggcacaca gaccccaacc     9720

acgacaccca tcaccaccac cactacggtg accccaaccc caacacccac cggcacacag     9780

accccaacca cgacacccat caccaccacc actacggtga ccccaacccc aacacccacc     9840

ggcacacaga ccccaaccac gacacccatc accaccacca ctacggtgac cccaacccca     9900

acacccaccg gcacacagac cccaaccacg acacccatca ccaccaccac tacggtgacc     9960

ccaaccccaa cacccaccgg cacacagacc ccaaccacga cacccatcac caccaccact    10020

acggtgaccc caaccccaac acccaccggc acacagaccc caaccacgac acccatcacc    10080

accaccacta cggtgacccc aaccccaaca cccaccggca cacagacccc aaccacgaca    10140

cccatcacca ccaccactac ggtgacccca accccaacac ccaccggcac acagacccca    10200

accacgacac ccatcaccac caccactacg gtgaccccaa ccccaacacc caccggcaca    10260

cagaccccaa ccacgacacc catcaccacc accactacgg tgaccccaac cccaacaccc    10320

accggcacac agaccccaac cacgacaccc atcaccacca ccactacggt gaccccaacc    10380

ccaacaccca ccggcacaca gaccccaacc acgacaccca tcaccaccac cactacggtg    10440

accccaaccc caacacccac cggcacacag accccaacca cgacacccat caccaccacc    10500

actacggtga ccccaacccc aacacccacc ggcacacaga ccccaaccac gacacccatc    10560

accaccacca ctacggtgac cccaacccca acacccaccg gcacacagac cccaaccacg    10620

acacccatca ccaccaccac tacggtgacc ccaaccccaa cacccaccgg cacacagacc    10680

ccaaccacga cacccatcac caccaccact acggtgaccc caaccccaac acccaccggc    10740

acacagaccc caaccacgac acccatcacc accaccacta cggtgacccc aaccccaaca    10800

cccaccggca cacagacccc aaccacgaca cccatcacca ccaccactac ggtgacccca    10860

accccaacac ccaccggcac acagacccca accacgacac ccatcaccac caccactacg    10920

gtgaccccaa ccccaacacc caccggcaca cagaccccaa ccacgacacc catcaccacc    10980

accactacgg tgaccccaac cccaacaccc accggcacac agaccccaac cacgacaccc    11040

atcaccacca ccactacggt gaccccaacc ccaacaccca ccggcacaca gaccccaacc    11100

acgacaccca tcaccaccac cactacggtg accccaaccc caacacccac cggcacacag    11160

accccaacca cgacacccat caccaccacc actacggtga ccccaacccc aacacccacc    11220

ggcacacaga ccccaaccac gacacccatc accaccacca ctacggtgac cccaacccca    11280

acacccaccg gcacacagac cccaaccacg acacccatca ccaccaccac tacggtgacc    11340

ccaaccccaa cacccaccgg cacacagacc ccaaccacga cacccatcac caccaccact    11400

acggtgaccc caaccccaac acccaccggc acacagaccc caaccacgac acccatcacc    11460

accaccacta cggtgacccc aaccccaaca cccaccggca cacagacccc aaccacgaca    11520

cccatcacca ccaccactac ggtgacccca accccaacac ccaccggcac acagacccca    11580

accacgacac ccatcaccac caccactacg gtgaccccaa ccccaacacc caccggcaca    11640

cagaccccaa ccacgacacc catcaccacc accactacgg tgaccccaac cccaacaccc    11700

accggcacac agaccccaac cacgacaccc atcaccacca ccactacggt gaccccaacc    11760

ccaacaccca ccggcacaca gaccccaacc acgacaccca tcaccaccac cactacggtg    11820

accccaaccc caacacccac cggcacacag accccaacca cgacacccat caccaccacc    11880

actacggtga ccccaacccc aacacccacc ggcacacaga ccccaaccac gacacccatc    11940

accaccacca ctacggtgac cccaacccca acacccaccg gcacacagac cccaaccacg    12000

acacccatca ccaccaccac tacggtgacc ccaaccccaa cacccaccgg cacacagacc    12060

ccaaccacga cacccatcac caccaccact acggtgaccc caaccccaac acccaccggc    12120

acacagaccc caaccacgac acccatcacc accaccacta cggtgacccc aaccccaaca    12180

cccaccggca cacagacccc aaccacgaca cccatcacca ccaccactac ggtgacccca    12240

accccaacac ccaccggcac acagacccca accacgacac ccatcaccac caccactacg    12300

gtgaccccaa ccccaacacc caccggcaca cagaccccaa ccacgacacc catcaccacc    12360

accactacgg tgaccccaac cccaacaccc accggcacac agaccccaac cacgacaccc    12420

atcaccacca ccactacggt gaccccaacc ccaacaccca ccggcacaca gaccccaacc    12480

acgacaccca tcaccaccac cactacggtg accccaaccc caacacccac cggcacacag    12540

accccaacca cgacacccat caccaccacc actacggtga ccccaacccc aacacccacc    12600

ggcacacaga ccgggccccc cacccacaca agcacagcac cgattgctga gttgaccaca    12660

tccaatcctc cgcctgagtc ctcaacccct cagacctctc ggtccacctc ttcccctctc    12720

acggagtcaa ccacccttct gagtacccta ccacctgcca ttgagatgac cagcacggcc    12780

ccaccctcca cacccacggc acccacgacc acgagcggag gccacacact gtctccaccg    12840

cccagcacca ccacgtcccc tccaggcacc cccactcgcg gtaccacgac tgggtcatct    12900

tcagccccca cccccagcac tgtgcagacg accaccacca gtgcctggac ccccacgccg    12960

accccactct ccacacccag catcatcagg accacaggcc tgaggcccta cccttcctct    13020

gtgcttatct gctgtgtcct gaacgacacc tactacgcac caggtgagga ggtgtacaac    13080

ggcacatacg gagacacctg ttatttcgtc aactgctcac tgagctgtac gttggagttc    13140

tataactggt cctgcccatc cacgccctcc ccaacaccca cgccctccaa gtcgacgccc    13200

acgccttcca agccatcgtc cacgccctcc aagccgacgc ccggcaccaa gccccccgag    13260

tgcccagact ttgatcctcc cagacaggag aacgagactt ggtggctgtg cgactgcttc    13320

atggccacgt gcaagtacaa caacacggtg gagatcgtga aggtggagtg tgagccgccg    13380

cccatgccca cctgctccaa cggcctccaa cccgtgcgcg tcgaggaccc cgacggctgc    13440

tgctggcact gggagtgcga ctgctactgc acgggctggg gcgacccgca ctatgtcacc    13500

ttcgacggac tctactacag ctaccagggc aactgcacct acgtgctggt ggaggagatc    13560

agcccctccg tggacaactt cggagtttac atcgacaact accactgcga tcccaacgac    13620

aaggtgtcct gcccccgcac cctcatcgtg cgccacgaga cccaggaggt gctgatcaag    13680

accgtgcata tgatgcccat gcaggtgcag gtgcaggtga acaggcaggc ggtggcactg    13740

ccctacaaga agtacgggct ggaggtgtac cagtctggca tcaactacgt ggtggacatc    13800

cccgagctgg gtgtcctcgt ctcctacaat ggcctgtcct tctccgtcag gctgccctac    13860

caccggtttg gcaacaacac caagggccag tgtggcacct gcaccaacac cacctccgac    13920

gactgcattc tgcccagcgg ggagatcgtc tccaactgtg aggctgcggc tgaccagtgg    13980

ctggtgaacg acccctccaa gccacactgc ccccacagca gctccacgac caagcgcccg    14040

gccgtcactg tgcccggggg cggtaaaacg accccacaca aggactgcac cccatctccc    14100

ctctgccagc tcatcaagga cagcctgttt gcccagtgcc acgcactggt gcccccgcag    14160

cactactacg atgcctgcgt gttcgacagc tgcttcatgc cgggctcgag cctggagtgc    14220

gccagtctgc aggcctacgc agccctctgt gcccagcaga acatctgcct cgactggcgg    14280

aaccacacgc atggggcctg cttggtggag tgcccatctc acagggagta ccaggcctgt    14340

ggccctgcag aagagcccac gtgcaaatcc agctcctccc agcagaacaa cacagtcctg    14400

gtggaaggct gcttctgtcc tgagggcacc atgaactacg ctcctggctt tgatgtctgc    14460

gtgaagacct gcggctgtgt gggacctgac aatgtgccca gagagtttgg ggagcacttc    14520

gagttcgact gcaagaactg tgtctgcctg gagggtggaa gtggcatcat ctgccaaccc    14580

aagaggtgca gccagaagcc cgttacccac tgcgtggaag acggcaccta cctcgccacg    14640

gaggtcaacc ctgccgacac ctgctgcaac attaccgtct gcaagtgcaa caccagcctg    14700

tgcaaagaga agccctccgt gtgcccgctg ggattcgaag tgaagagcaa gatggtgcct    14760

ggaaggtgct gtcctttcta ctggtgtgag tccaaggggg tgtgtgttca cgggaatgct    14820

gagtaccagc ccggttctcc agtttattcc tccaagtgcc aggactgcgt gtgcacggac    14880

aaggtggaca acaacaccct gctcaacgtc atcgcctgca cccacgtgcc ctgcaacacc    14940

tcctgcagcc ctggcttcga actcatggag gcccccgggg agtgctgtaa gaagtgtgaa    15000

cagacgcact gtatcatcaa acggcccgac aaccagcacg tcatcctgaa gcccggggac    15060

ttcaagagcg acccgaagaa caactgcaca ttcttcagct gcgtgaagat ccacaaccag    15120

ctcatctcgt ccgtctccaa catcacctgc cccaactttg atgccagcat ttgcatcccg    15180

ggctccatca cattcatgcc caatggatgc tgcaagacct gcacccctcg caatgagacc    15240

agggtgccct gctccaccgt ccccgtcacc acggaggttt cgtacgccgg ctgcaccaag    15300

accgtcctca tgaatcattg ctccgggtcc tgcgggacat ttgtcatgta ctcggccaag    15360

gcccaggccc tggaccacag ctgctcctgc tgcaaagagg agaaaaccag ccagcgtgag    15420

gtggtcctga gctgccccaa tggcggctcg ctgacacaca cctacaccca catcgagagc    15480

tgccagtgcc aggacaccgt ctgcgggctc cccaccggca cctcccgccg ggcccggcgc    15540

tcccctaggc atctggggag cgggtgagcg gggtgggcac agcccccttc actgccctcg    15600

acagctttac ctcccccgga ccctctgagc ctcctaagct cggcttcctc tcttcagata    15660

tttattgtct gagtctttgt tcagtccttg ctttccaata ataaactcag ggggacatgc    15720


<210> 31
<211> 324
<212> PRT
<213> Homo sapiens

<400> 31
Met Phe Pro Ser Pro Ala Leu Thr Pro Thr Pro Phe Ser Val Lys Asp 
1               5                   10                  15      


Ile Leu Asn Leu Glu Gln Gln Gln Arg Ser Leu Ala Ala Ala Gly Glu 
            20                  25                  30          


Leu Ser Ala Arg Leu Glu Ala Thr Leu Ala Pro Ser Ser Cys Met Leu 
        35                  40                  45              


Ala Ala Phe Lys Pro Glu Ala Tyr Ala Gly Pro Glu Ala Ala Ala Pro 
    50                  55                  60                  


Gly Leu Pro Glu Leu Arg Ala Glu Leu Gly Arg Ala Pro Ser Pro Ala 
65                  70                  75                  80  


Lys Cys Ala Ser Ala Phe Pro Ala Ala Pro Ala Phe Tyr Pro Arg Ala 
                85                  90                  95      


Tyr Ser Asp Pro Asp Pro Ala Lys Asp Pro Arg Ala Glu Lys Lys Glu 
            100                 105                 110         


Leu Cys Ala Leu Gln Lys Ala Val Glu Leu Glu Lys Thr Glu Ala Asp 
        115                 120                 125             


Asn Ala Glu Arg Pro Arg Ala Arg Arg Arg Arg Lys Pro Arg Val Leu 
    130                 135                 140                 


Phe Ser Gln Ala Gln Val Tyr Glu Leu Glu Arg Arg Phe Lys Gln Gln 
145                 150                 155                 160 


Arg Tyr Leu Ser Ala Pro Glu Arg Asp Gln Leu Ala Ser Val Leu Lys 
                165                 170                 175     


Leu Thr Ser Thr Gln Val Lys Ile Trp Phe Gln Asn Arg Arg Tyr Lys 
            180                 185                 190         


Cys Lys Arg Gln Arg Gln Asp Gln Thr Leu Glu Leu Val Gly Leu Pro 
        195                 200                 205             


Pro Pro Pro Pro Pro Pro Ala Arg Arg Ile Ala Val Pro Val Leu Val 
    210                 215                 220                 


Arg Asp Gly Lys Pro Cys Leu Gly Asp Ser Ala Pro Tyr Ala Pro Ala 
225                 230                 235                 240 


Tyr Gly Val Gly Leu Asn Pro Tyr Gly Tyr Asn Ala Tyr Pro Ala Tyr 
                245                 250                 255     


Pro Gly Tyr Gly Gly Ala Ala Cys Ser Pro Gly Tyr Ser Cys Thr Ala 
            260                 265                 270         


Ala Tyr Pro Ala Gly Pro Ser Pro Ala Gln Pro Ala Thr Ala Ala Ala 
        275                 280                 285             


Asn Asn Asn Phe Val Asn Phe Gly Val Gly Asp Leu Asn Ala Val Gln 
    290                 295                 300                 


Ser Pro Gly Ile Pro Gln Ser Asn Ser Gly Val Ser Thr Leu His Gly 
305                 310                 315                 320 


Ile Arg Ala Trp 
                


<210> 32
<211> 1669
<212> DNA
<213> Homo sapiens

<400> 32
gctcctgtca tcgaggcccc tggcccaatg gcaggctgag tccccctcct ctggcctggt       60

cccgcctctc ctgccccttg tgctcagcgc tacctgctgc ccggacacat ccagagctgg      120

ccgacgggtg cgcgggcggg cggcggcacc atgcagggaa gctgccaggg gccgtgggca      180

gcgccgcttt ctgccgccca cctggcgctg tgagactggc gctgccacca tgttccccag      240

ccctgctctc acgcccacgc ccttctcagt caaagacatc ctaaacctgg aacagcagca      300

gcgcagcctg gctgccgccg gagagctctc tgcccgcctg gaggcgaccc tggcgccctc      360

ctcctgcatg ctggccgcct tcaagccaga ggcctacgct gggcccgagg cggctgcgcc      420

gggcctccca gagctgcgcg cagagctggg ccgcgcgcct tcaccggcca agtgtgcgtc      480

tgcctttccc gccgcccccg ccttctatcc acgtgcctac agcgaccccg acccagccaa      540

ggaccctaga gccgaaaaga aagagctgtg cgcgctgcag aaggcggtgg agctggagaa      600

gacagaggcg gacaacgcgg agcggccccg ggcgcgacgg cggaggaagc cgcgcgtgct      660

cttctcgcag gcgcaggtct atgagctgga gcggcgcttc aagcagcagc ggtacctgtc      720

ggcccccgaa cgcgaccagc tggccagcgt gctgaaactc acgtccacgc aggtcaagat      780

ctggttccag aaccggcgct acaagtgcaa gcggcagcgg caggaccaga ctctggagct      840

ggtggggctg cccccgccgc cgccgccgcc tgcccgcagg atcgcggtgc cagtgctggt      900

gcgcgatggc aagccatgcc taggggactc ggcgccctac gcgcctgcct acggcgtggg      960

cctcaatccc tacggttata acgcctaccc cgcctatccg ggttacggcg gcgcggcctg     1020

cagccctggc tacagctgca ctgccgctta ccccgccggg ccttccccag cgcagccggc     1080

cactgccgcc gccaacaaca acttcgtgaa cttcggcgtc ggggacttga atgcggttca     1140

gagccccggg attccgcaga gcaactcggg agtgtccacg ctgcatggta tccgagcctg     1200

gtagggaagg gacccgcgtg gcgcgaccct gaccgatccc acctcaacag ctccctgact     1260

ctcgggggga gaaggggctc ccaacatgac cctgagtccc ctggattttg cattcactcc     1320

tgcggagacc taggaacttt ttctgtccca cgcgcgtttg ttcttgcgca cgggagagtt     1380

tgtggcggcg attatgcagc gtgcaatgag tgatcctgca gcctggtgtc ttagctgtcc     1440

ccccaggagt gccctccgag agtccatggg cacccccggt tggaactggg actgagctcg     1500

ggcacgcagg gcctgagatc tggccgccca ttccgcgagc cagggccggg cgcccgggcc     1560

tttgctatct cgccgtcgcc cgcccacgca cccacccgta tttatgtttt tacctattgc     1620

tgtaagaaat gacgatcccc ttcccattaa agagagtgcg ttgaccccg                 1669


<210> 33
<211> 356
<212> PRT
<213> Homo sapiens

<400> 33
Met Thr Lys Ser Tyr Ser Glu Ser Gly Leu Met Gly Glu Pro Gln Pro 
1               5                   10                  15      


Gln Gly Pro Pro Ser Trp Thr Asp Glu Cys Leu Ser Ser Gln Asp Glu 
            20                  25                  30          


Glu His Glu Ala Asp Lys Lys Glu Asp Asp Leu Glu Ala Met Asn Ala 
        35                  40                  45              


Glu Glu Asp Ser Leu Arg Asn Gly Gly Glu Glu Glu Asp Glu Asp Glu 
    50                  55                  60                  


Asp Leu Glu Glu Glu Glu Glu Glu Glu Glu Glu Asp Asp Asp Gln Lys 
65                  70                  75                  80  


Pro Lys Arg Arg Gly Pro Lys Lys Lys Lys Met Thr Lys Ala Arg Leu 
                85                  90                  95      


Glu Arg Phe Lys Leu Arg Arg Met Lys Ala Asn Ala Arg Glu Arg Asn 
            100                 105                 110         


Arg Met His Gly Leu Asn Ala Ala Leu Asp Asn Leu Arg Lys Val Val 
        115                 120                 125             


Pro Cys Tyr Ser Lys Thr Gln Lys Leu Ser Lys Ile Glu Thr Leu Arg 
    130                 135                 140                 


Leu Ala Lys Asn Tyr Ile Trp Ala Leu Ser Glu Ile Leu Arg Ser Gly 
145                 150                 155                 160 


Lys Ser Pro Asp Leu Val Ser Phe Val Gln Thr Leu Cys Lys Gly Leu 
                165                 170                 175     


Ser Gln Pro Thr Thr Asn Leu Val Ala Gly Cys Leu Gln Leu Asn Pro 
            180                 185                 190         


Arg Thr Phe Leu Pro Glu Gln Asn Gln Asp Met Pro Pro His Leu Pro 
        195                 200                 205             


Thr Ala Ser Ala Ser Phe Pro Val His Pro Tyr Ser Tyr Gln Ser Pro 
    210                 215                 220                 


Gly Leu Pro Ser Pro Pro Tyr Gly Thr Met Asp Ser Ser His Val Phe 
225                 230                 235                 240 


His Val Lys Pro Pro Pro His Ala Tyr Ser Ala Ala Leu Glu Pro Phe 
                245                 250                 255     


Phe Glu Ser Pro Leu Thr Asp Cys Thr Ser Pro Ser Phe Asp Gly Pro 
            260                 265                 270         


Leu Ser Pro Pro Leu Ser Ile Asn Gly Asn Phe Ser Phe Lys His Glu 
        275                 280                 285             


Pro Ser Ala Glu Phe Glu Lys Asn Tyr Ala Phe Thr Met His Tyr Pro 
    290                 295                 300                 


Ala Ala Thr Leu Ala Gly Ala Gln Ser His Gly Ser Ile Phe Ser Gly 
305                 310                 315                 320 


Thr Ala Ala Pro Arg Cys Glu Ile Pro Ile Asp Asn Ile Met Ser Phe 
                325                 330                 335     


Asp Ser His Ser His His Glu Arg Val Met Ser Ala Gln Leu Asn Ala 
            340                 345                 350         


Ile Phe His Asp 
        355     


<210> 34
<211> 3002
<212> DNA
<213> Homo sapiens

<400> 34
ggggaggagg ggagaacggg gagcgcacag cctggacgcg tgcgcaggcg tcaggcgcat       60

agacctgcta gcccctcagc tagcggcccc gcccgcgctt agcatcacta actgggctat      120

ataacctgag cgcccgcgcg gccacgacac gaggaattcg cccacgcagg aggcgcggcg      180

tccggaggcc ccagggttat gagactatca ctgctcagga cctactaaca acaaaggaaa      240

tcgaaacatg accaaatcgt acagcgagag tgggctgatg ggcgagcctc agccccaagg      300

tcctccaagc tggacagacg agtgtctcag ttctcaggac gaggagcacg aggcagacaa      360

gaaggaggac gacctcgaag ccatgaacgc agaggaggac tcactgagga acgggggaga      420

ggaggaggac gaagatgagg acctggaaga ggaggaagaa gaggaagagg aggatgacga      480

tcaaaagccc aagagacgcg gccccaaaaa gaagaagatg actaaggctc gcctggagcg      540

ttttaaattg agacgcatga aggctaacgc ccgggagcgg aaccgcatgc acggactgaa      600

cgcggcgcta gacaacctgc gcaaggtggt gccttgctat tctaagacgc agaagctgtc      660

caaaatcgag actctgcgct tggccaagaa ctacatctgg gctctgtcgg agatcctgcg      720

ctcaggcaaa agcccagacc tggtctcctt cgttcagacg ctttgcaagg gcttatccca      780

acccaccacc aacctggttg cgggctgcct gcaactcaat cctcggactt ttctgcctga      840

gcagaaccag gacatgcccc cccacctgcc gacggccagc gcttccttcc ctgtacaccc      900

ctactcctac cagtcgcctg ggctgcccag tccgccttac ggtaccatgg acagctccca      960

tgtcttccac gttaagcctc cgccgcacgc ctacagcgca gcgctggagc ccttctttga     1020

aagccctctg actgattgca ccagcccttc ctttgatgga cccctcagcc cgccgctcag     1080

catcaatggc aacttctctt tcaaacacga accgtccgcc gagtttgaga aaaattatgc     1140

ctttaccatg cactatcctg cagcgacact ggcaggggcc caaagccacg gatcaatctt     1200

ctcaggcacc gctgcccctc gctgcgagat ccccatagac aatattatgt ccttcgatag     1260

ccattcacat catgagcgag tcatgagtgc ccagctcaat gccatatttc atgattagag     1320

gcacgccagt ttcaccattt ccgggaaacg aacccactgt gcttacagtg actgtcgtgt     1380

ttacaaaagg cagccctttg ggtactactg ctgcaaagtg caaatactcc aagcttcaag     1440

tgatatatgt atttattgtc attactgcct ttggaagaaa caggggatca aagttcctgt     1500

tcaccttatg tattattttc tatagctctt ctatttaaaa aataaaaaaa tacagtaaag     1560

tttaaaaaat acaccacgaa tttggtgtgg ctgtattcag atcgtattaa ttatctgatc     1620

gggataacaa aatcacaagc aataattagg atctatgcaa tttttaaact agtaatgggc     1680

caattaaaat atatataaat atatattttt caaccagcat tttactactt gttacctttc     1740

ccatgctgaa ttattttgtt gtgattttgt acagaatttt taatgacttt ttataatgtg     1800

gatttcctat tttaaaacca tgcagcttca tcaattttta tacatatcag aaaagtagaa     1860

ttatatctaa tttatacaaa ataatttaac taatttaaac cagcagaaaa gtgcttagaa     1920

agttattgtg ttgccttagc acttctttcc tctccaattg taaaaaaaaa aaaaaaaaaa     1980

aaaaaaaaaa aaaaattgca caatttgagc aattcatttc actttaaagt ctttccgtct     2040

ccctaaaata aaaaccagaa tcataatttt caagagaaga aaaaattaag agatacattc     2100

cctatcaaaa catatcaatt caacacatta cttgcacaag cttgtatata catattataa     2160

ataaatgcca acataccctt ctttaaatca aaagctgctt gactatcaca tacaatttgc     2220

actgttactt tttagtcttt tactcctttg cattccatga ttttacagag aatctgaagc     2280

tattgatgtt tccagaaaat ataaatgcat gattttatac atagtcacaa aaatggtggt     2340

ttgtcatata ttcatgtaat aaatctgagc ctaaatctaa tcaggttgtt aatgttggga     2400

tttatatcta tagtagtcaa ttagtacagt agcttaaata aattcaaacc atttaattca     2460

taattagaac aatagctatt gcatgtaaaa tgcagtccag aataagtgct gtttgagatg     2520

tgatgctggt accactggaa tcgatctgta ctgtaatttt gtttgtaatc ctgtatatta     2580

tggtgtaatg cacaatttag aaaacattca tccagttgca ataaaatagt attgaaagtg     2640

agagcaattg ttgcatttct tcttaaaggg attctgtttt tatttttggg gaaagtagtt     2700

gcttttttgc tgagttaaaa aatactaaac actatatgta gaataaaaga aaagaaaaaa     2760

gtttaccttg gcatatgctc ttgtctgttt atcttgcaca gggagtcacc agttctatgt     2820

agataatgaa aagacctaac tgatatttca ttatttggaa tatgggactg gacggcagta     2880

caaacagtgt gtttttttct ttgttttaag tggcttagcc tttaggtttt ttatttccat     2940

ttttaaaaat gattgttaca tgttttcttc tatttctttt tttaaaaggt ggattttaat     3000

aa                                                                    3002


<210> 35
<211> 367
<212> PRT
<213> Homo sapiens

<400> 35
Met Leu Ala Val Gly Ala Met Glu Gly Thr Arg Gln Ser Ala Phe Leu 
1               5                   10                  15      


Leu Ser Ser Pro Pro Leu Ala Ala Leu His Ser Met Ala Glu Met Lys 
            20                  25                  30          


Thr Pro Leu Tyr Pro Ala Ala Tyr Pro Pro Leu Pro Ala Gly Pro Pro 
        35                  40                  45              


Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Pro Ser Pro Pro Leu 
    50                  55                  60                  


Gly Thr His Asn Pro Gly Gly Leu Lys Pro Pro Ala Thr Gly Gly Leu 
65                  70                  75                  80  


Ser Ser Leu Gly Ser Pro Pro Gln Gln Leu Ser Ala Ala Thr Pro His 
                85                  90                  95      


Gly Ile Asn Asp Ile Leu Ser Arg Pro Ser Met Pro Val Ala Ser Gly 
            100                 105                 110         


Ala Ala Leu Pro Ser Ala Ser Pro Ser Gly Ser Ser Ser Ser Ser Ser 
        115                 120                 125             


Ser Ser Ala Ser Ala Ser Ser Ala Ser Ala Ala Ala Ala Ala Ala Ala 
    130                 135                 140                 


Ala Ala Ala Ala Ala Ala Ser Ser Pro Ala Gly Leu Leu Ala Gly Leu 
145                 150                 155                 160 


Pro Arg Phe Ser Ser Leu Ser Pro Pro Pro Pro Pro Pro Gly Leu Tyr 
                165                 170                 175     


Phe Ser Pro Ser Ala Ala Ala Val Ala Ala Val Gly Arg Tyr Pro Lys 
            180                 185                 190         


Pro Leu Ala Glu Leu Pro Gly Arg Thr Pro Ile Phe Trp Pro Gly Val 
        195                 200                 205             


Met Gln Ser Pro Pro Trp Arg Asp Ala Arg Leu Ala Cys Thr Pro His 
    210                 215                 220                 


Gln Gly Ser Ile Leu Leu Asp Lys Asp Gly Lys Arg Lys His Thr Arg 
225                 230                 235                 240 


Pro Thr Phe Ser Gly Gln Gln Ile Phe Ala Leu Glu Lys Thr Phe Glu 
                245                 250                 255     


Gln Thr Lys Tyr Leu Ala Gly Pro Glu Arg Ala Arg Leu Ala Tyr Ser 
            260                 265                 270         


Leu Gly Met Thr Glu Ser Gln Val Lys Val Trp Phe Gln Asn Arg Arg 
        275                 280                 285             


Thr Lys Trp Arg Lys Lys His Ala Ala Glu Met Ala Thr Ala Lys Lys 
    290                 295                 300                 


Lys Gln Asp Ser Glu Thr Glu Arg Leu Lys Gly Ala Ser Glu Asn Glu 
305                 310                 315                 320 


Glu Glu Asp Asp Asp Tyr Asn Lys Pro Leu Asp Pro Asn Ser Asp Asp 
                325                 330                 335     


Glu Lys Ile Thr Gln Leu Leu Lys Lys His Lys Ser Ser Ser Gly Gly 
            340                 345                 350         


Gly Gly Gly Leu Leu Leu His Ala Ser Glu Pro Glu Ser Ser Ser 
        355                 360                 365         


<210> 36
<211> 1116
<212> DNA
<213> Homo sapiens

<400> 36
cgtgggatgt tagcggtggg ggcaatggag ggcacccggc agagcgcatt cctgctcagc       60

agccctcccc tggccgccct gcacagcatg gccgagatga agaccccgct gtaccctgcc      120

gcgtatcccc cgctgcctgc cggccccccc tcctcctcgt cctcgtcgtc gtcctcctcg      180

tcgccctccc cgcctctggg cacccacaac ccaggcggcc tgaagccccc ggccacgggg      240

gggctctcat ccctcggcag ccccccgcag cagctctcgg ccgccacccc acacggcatc      300

aacgatatcc tgagccggcc ctccatgccc gtggcctcgg gggccgccct gccctccgcc      360

tcgccctccg gttcctcctc ctcctcttcc tcgtccgcct ctgcctcctc cgcctctgcc      420

gccgccgcgg ctgctgccgc ggccgcagcc gccgcctcat ccccggcggg gctgctggcc      480

ggactgccac gctttagcag cctgagcccg ccgccgccgc cgcccgggct ctacttcagc      540

cccagcgccg cggccgtggc cgccgtgggc cggtacccca agccgctggc tgagctgcct      600

ggccggacgc ccatcttctg gcccggagtg atgcagagcc cgccctggag ggacgcacgc      660

ctggcctgta cccctcatca aggatccatt ttgttggaca aagacgggaa gagaaaacac      720

acgagaccca ctttttccgg acagcagatc ttcgccctgg agaagacttt cgaacaaaca      780

aaatacttgg cggggcccga gagggctcgt ttggcctatt cgttggggat gacagagagt      840

caggtcaagg tctggttcca gaaccgccgg accaagtgga ggaagaagca cgctgccgag      900

atggccacgg ccaagaagaa gcaggactcg gagacagagc gcctcaaggg ggcctcggag      960

aacgaggaag aggacgacga ctacaataag cctctggatc ccaactcgga cgacgagaaa     1020

atcacgcagc tgttgaagaa gcacaagtcc agcagcggcg gcggcggcgg cctcctactg     1080

cacgcgtccg agccggagag ctcatcctga acgccg                               1116


<210> 37
<211> 353
<212> PRT
<213> Homo sapiens

<400> 37
Met Ala Ala Glu Leu Ala Met Gly Ala Glu Leu Pro Ser Ser Pro Leu 
1               5                   10                  15      


Ala Ile Glu Tyr Val Asn Asp Phe Asp Leu Met Lys Phe Glu Val Lys 
            20                  25                  30          


Lys Glu Pro Pro Glu Ala Glu Arg Phe Cys His Arg Leu Pro Pro Gly 
        35                  40                  45              


Ser Leu Ser Ser Thr Pro Leu Ser Thr Pro Cys Ser Ser Val Pro Ser 
    50                  55                  60                  


Ser Pro Ser Phe Cys Ala Pro Ser Pro Gly Thr Gly Gly Gly Gly Gly 
65                  70                  75                  80  


Ala Gly Gly Gly Gly Gly Ser Ser Gln Ala Gly Gly Ala Pro Gly Pro 
                85                  90                  95      


Pro Ser Gly Gly Pro Gly Ala Val Gly Gly Thr Ser Gly Lys Pro Ala 
            100                 105                 110         


Leu Glu Asp Leu Tyr Trp Met Ser Gly Tyr Gln His His Leu Asn Pro 
        115                 120                 125             


Glu Ala Leu Asn Leu Thr Pro Glu Asp Ala Val Glu Ala Leu Ile Gly 
    130                 135                 140                 


Ser Gly His His Gly Ala His His Gly Ala His His Pro Ala Ala Ala 
145                 150                 155                 160 


Ala Ala Tyr Glu Ala Phe Arg Gly Pro Gly Phe Ala Gly Gly Gly Gly 
                165                 170                 175     


Ala Asp Asp Met Gly Ala Gly His His His Gly Ala His His Ala Ala 
            180                 185                 190         


His His His His Ala Ala His His His His His His His His His His 
        195                 200                 205             


Gly Gly Ala Gly His Gly Gly Gly Ala Gly His His Val Arg Leu Glu 
    210                 215                 220                 


Glu Arg Phe Ser Asp Asp Gln Leu Val Ser Met Ser Val Arg Glu Leu 
225                 230                 235                 240 


Asn Arg Gln Leu Arg Gly Phe Ser Lys Glu Glu Val Ile Arg Leu Lys 
                245                 250                 255     


Gln Lys Arg Arg Thr Leu Lys Asn Arg Gly Tyr Ala Gln Ser Cys Arg 
            260                 265                 270         


Phe Lys Arg Val Gln Gln Arg His Ile Leu Glu Ser Glu Lys Cys Gln 
        275                 280                 285             


Leu Gln Ser Gln Val Glu Gln Leu Lys Leu Glu Val Gly Arg Leu Ala 
    290                 295                 300                 


Lys Glu Arg Asp Leu Tyr Lys Glu Lys Tyr Glu Lys Leu Ala Gly Arg 
305                 310                 315                 320 


Gly Gly Pro Gly Ser Ala Gly Gly Ala Gly Phe Pro Arg Glu Pro Ser 
                325                 330                 335     


Pro Pro Gln Ala Gly Pro Gly Gly Ala Lys Gly Thr Ala Asp Phe Phe 
            340                 345                 350         


Leu 
    


<210> 38
<211> 2058
<212> DNA
<213> Homo sapiens

<400> 38
gggtccttca ggtaggaggt cctgggtgac tttggaagtc cgtagtgtct cattgcagat       60

aatttttagc ttagggcctg gtggctaggt cggttctctc ctttccagtc ggagacctct      120

gccgcaaaca tgctccgcca gatcatcggt caggccaaga agcatccgag cttgatcccc      180

ctctttgtat ttattggaac tggagctact ggagcaacac tgtatctctt gcgtctggca      240

ttgttcaatc cagatgtttg ttgggacaga aataacccag agccctggaa caaactgggt      300

cccaatgatc aatacaagtt ctactcagtg aatgtggatt acagcaagct gaagaaggaa      360

cgtccagatt tctaaatgaa atgtttcact ataacgctgc tttagaatga aggtcttcca      420

gaagccacat ccgcacaatt ttccacttaa ccaggaaata tttctcctct aaatgcatga      480

aatcatgttg gagatctcta ttgtaatctc tattggagat tacaatgatt aaatcaataa      540

ataactgaaa cttgatatgt gtcacttttt tatgctgaaa gtatgctctg aactttagag      600

tataggaaat taactattag aatttaaaga atttcttgaa tttctgtagt ttgaaaatac      660

gactttaagc tgctttagta aaacacttcc attttgtgta tagactgttg gtaacttcac      720

tagagcatac ataacaactg gaactggaaa ttatacaaaa gtaaattggg aaggatactc      780

cagcatctga cactggcaaa atggaaacct ttgagtttct cttactggct gttgaagtgt      840

gtgcagtttt taacaatggt ttttacttgg catctctttg ttgtgatttt caaggttata      900

agttgctttg gtcctaggat tgaagttgaa atctgagttt atcagtgcta accatggtgc      960

tagtagtcaa gagatcttga gaattttggc tgctgagtct tggtgcaggg tgcaggtttt     1020

cttttctttt ttcttttttt tttttttgag atagtctctg tcacccaggc tggagtgcag     1080

tggtacaaac atggatcact gcagcctcta cctcccgggc ttaagtgatc ctcctgcctc     1140

agcccctaag tagccgggac tacaggtatg tgccaccatg cccagttaat ttttgtaatt     1200

ttttttagag acagggtttt gccatgttgc ccaggctggt ctcaaactct tgagctcaag     1260

cgatccattc tcctcagcct cccagggtgc tgggattaca ggcgtgagcc attgcgctta     1320

gccatggtgc aggttttcaa aggccaggaa gtatattcat aattttaaga tggggaatat     1380

agcaagtttt cacataggtg tgtgtaagtc atcacatcat agaaacttga ggaattcagt     1440

gacattaatt ttggattttc atacgtaagt atacaattaa atgtttacag ggtagtagaa     1500

gcacatttta aatgtcagga actgaactaa gtatttgaat tacgtggatt atctcaaaaa     1560

ttttgaaatt gttaaacgag ttgaattact tgaattcatt ctgttagtca aatggtggat     1620

atttacaccc atgtagtttt gaatttagag tgtgtagagt gttttcagtt accagactcc     1680

atgcttttac ctcctatgtg tcaggtataa tttgaacctc taagaacagg gtttctcaac     1740

cttgccactg ttgactattt ctgaaagaca gtttggttta gcagaccatc ccatgcgctt     1800

tagcttgttt agtagctaac ttgggctctg ccactacaga caaaaagcac tctttccctc     1860

caattcccac aggctatgag aagaatggag acattaccaa atgtccattg gtgggcaaaa     1920

ttgcttcatt cctacctctg ttgagaatta ctctagatcc tttggcacaa attacctcaa     1980

agtttaaaat tgtgtaaaca aacagtgtgt catgtaattg aaaaacatta agcaactcca     2040

aataaatgct acattaag                                                   2058


<210> 39
<211> 343
<212> PRT
<213> Homo sapiens

<400> 39
Met Asn Gln Leu Gly Gly Leu Phe Val Asn Gly Arg Pro Leu Pro Leu 
1               5                   10                  15      


Asp Thr Arg Gln Gln Ile Val Arg Leu Ala Val Ser Gly Met Arg Pro 
            20                  25                  30          


Cys Asp Ile Ser Arg Ile Leu Lys Val Ser Asn Gly Cys Val Ser Lys 
        35                  40                  45              


Ile Leu Gly Arg Tyr Tyr Arg Thr Gly Val Leu Glu Pro Lys Gly Ile 
    50                  55                  60                  


Gly Gly Ser Lys Pro Arg Leu Ala Thr Pro Pro Val Val Ala Arg Ile 
65                  70                  75                  80  


Ala Gln Leu Lys Gly Glu Cys Pro Ala Leu Phe Ala Trp Glu Ile Gln 
                85                  90                  95      


Arg Gln Leu Cys Ala Glu Gly Leu Cys Thr Gln Asp Lys Thr Pro Ser 
            100                 105                 110         


Val Ser Ser Ile Asn Arg Val Leu Arg Ala Leu Gln Glu Asp Gln Gly 
        115                 120                 125             


Leu Pro Cys Thr Arg Leu Arg Ser Pro Ala Val Leu Ala Pro Ala Val 
    130                 135                 140                 


Leu Thr Pro His Ser Gly Ser Glu Thr Pro Arg Gly Thr His Pro Gly 
145                 150                 155                 160 


Thr Gly His Arg Asn Arg Thr Ile Phe Ser Pro Ser Gln Ala Glu Ala 
                165                 170                 175     


Leu Glu Lys Glu Phe Gln Arg Gly Gln Tyr Pro Asp Ser Val Ala Arg 
            180                 185                 190         


Gly Lys Leu Ala Thr Ala Thr Ser Leu Pro Glu Asp Thr Val Arg Val 
        195                 200                 205             


Trp Phe Ser Asn Arg Arg Ala Lys Trp Arg Arg Gln Glu Lys Leu Lys 
    210                 215                 220                 


Trp Glu Met Gln Leu Pro Gly Ala Ser Gln Gly Leu Thr Val Pro Arg 
225                 230                 235                 240 


Val Ala Pro Gly Ile Ile Ser Ala Gln Gln Ser Pro Gly Ser Val Pro 
                245                 250                 255     


Thr Ala Ala Leu Pro Ala Leu Glu Pro Leu Gly Pro Ser Cys Tyr Gln 
            260                 265                 270         


Leu Cys Trp Ala Thr Ala Pro Glu Arg Cys Leu Ser Asp Thr Pro Pro 
        275                 280                 285             


Lys Ala Cys Leu Lys Pro Cys Trp Gly His Leu Pro Pro Gln Pro Asn 
    290                 295                 300                 


Ser Leu Asp Ser Gly Leu Leu Cys Leu Pro Cys Pro Ser Ser His Cys 
305                 310                 315                 320 


His Leu Ala Ser Leu Ser Gly Ser Gln Ala Leu Leu Trp Pro Gly Cys 
                325                 330                 335     


Pro Leu Leu Tyr Gly Leu Glu 
            340             


<210> 40
<211> 2010
<212> DNA
<213> Homo sapiens

<400> 40
caaagactca cccgtgagcc agctctcaaa gaaagcagct tgcgttgaca gcctgggggc       60

agcaaggatg cagtctccca ggagaggatg cactcggtgg tgggaagcca ggctggaggg      120

gcctgagtga ccctctccac aggcgggcag ggcagtggga gaggtggtgt gtggatacct      180

ctgtctcacg cccagggatc agcagcatga accagcttgg ggggctcttt gtgaatggcc      240

ggcccctgcc tctggatacc cggcagcaga ttgtgcggct agcagtcagt ggaatgcggc      300

cctgtgacat ctcacggatc cttaaggtat ctaatggctg tgtgagcaag atcctagggc      360

gttactaccg cacaggtgtc ttggagccaa agggcattgg gggaagcaag ccacggctgg      420

ctacaccccc tgtggtggct cgaattgccc agctgaaggg tgagtgtcca gccctctttg      480

cctgggaaat ccaacgccag ctttgtgctg aagggctttg cacccaggac aagactccca      540

gtgtctcctc catcaaccga gtcctgcggg cattacagga ggaccaggga ctaccgtgca      600

cacggctcag gtcaccagct gttttggctc cagctgtcct cactccccat agtggctctg      660

agactccccg gggtacccac ccagggaccg gccaccggaa tcggactatc ttctccccaa      720

gccaagcaga ggcactggag aaagagttcc agcgtgggca gtatcctgat tcagtggccc      780

gtggaaagct ggctactgcc acctctctgc ctgaggacac ggtgagggtc tggttttcca      840

acagaagagc caaatggcgt cggcaagaga agctcaagtg ggaaatgcag ctgccaggtg      900

cttcccaggg gctgactgta ccaagggttg ccccaggaat catctctgca cagcagtccc      960

ctggcagtgt gcccacagca gccctgcctg ccctggaacc actgggtccc tcctgctatc     1020

agctgtgctg ggcaacagca ccagaaaggt gtctgagtga caccccacct aaagcctgtc     1080

tcaagccctg ctggggccac ttgcccccac agccgaattc cctggactca ggactgcttt     1140

gccttccttg cccttcctcc cactgtcacc tggccagtct tagtggctct caggccctgc     1200

tctggcctgg ctgcccacta ctgtatggct tggaatgagg caggagtggg aaggagatgg     1260

catagagaag atctaatacc atcctgccca ttgtccttac cgtcctgccc atacagactg     1320

tggctccttc ctccttcctg tgattgctcc ctcctgtgtg gacgttgcct ggccctgcct     1380

cgatgcctct ctggcgcatc acctgattgg aggggctggt aaagcaacac ccacccactt     1440

ctcacactag ccttaagagg cctccactca gcagtaataa aagctgtttt tattagcagt     1500

agttctgttg tccatcatgt tttccctatg agcaccccta tgcccactct aatattcaac     1560

aattatagac aatttgccct atcatttatt tacatctatg tatctaccat ctaatctatg     1620

catgtatgta ggcaatacat gtatctaaac aatgtatttg tcaatgcatc aatttaccta     1680

ctctatgtat gcatctatat gtgtattatg tatgcgtgca tgcgtgcgcg cacacacaca     1740

cacacacaca cacactgaca ttatatcatg gcattttatt cctaaatctt ccagcatgca     1800

tccccaaaaa acaagaaact tgtcttacat aatcacaata atatatccac atctaagaaa     1860

atttactgta acttcttaat ctaagaaaat tatgtatttt tgtcatatgt attttgtcat     1920

atgtattttg tatttgcata tgtattttgt atttgcatat gtatttttgt catagcagca     1980

aacagagtga aatgccattt ttcatattct                                      2010


<210> 41
<211> 286
<212> PRT
<213> Homo sapiens

<400> 41
Met Gly Ala Asp Gly Met Tyr Asp Lys Leu Arg Met Leu Asn Gly Gln 
1               5                   10                  15      


Thr Gly Ser Trp Gly Thr Arg Pro Gly Trp Tyr Pro Gly Thr Ser Val 
            20                  25                  30          


Pro Gly Gln Pro Thr Gln Asp Gly Cys Gln Gln Gln Glu Gly Gly Gly 
        35                  40                  45              


Glu Asn Thr Asn Ser Ile Ser Ser Asn Gly Glu Asp Ser Asp Glu Ala 
    50                  55                  60                  


Gln Met Arg Leu Gln Leu Lys Arg Lys Leu Gln Arg Asn Arg Thr Ser 
65                  70                  75                  80  


Phe Thr Gln Glu Gln Ile Glu Ala Leu Glu Lys Glu Phe Glu Arg Thr 
                85                  90                  95      


His Tyr Pro Asp Val Phe Ala Arg Glu Arg Leu Ala Ala Lys Ile Asp 
            100                 105                 110         


Leu Pro Glu Ala Arg Ile Gln Val Trp Phe Ser Asn Arg Arg Ala Lys 
        115                 120                 125             


Trp Arg Arg Glu Glu Lys Leu Arg Asn Gln Arg Arg Gln Ala Ser Asn 
    130                 135                 140                 


Thr Pro Ser His Ile Pro Ile Ser Ser Ser Phe Ser Thr Ser Val Tyr 
145                 150                 155                 160 


Gln Pro Ile Pro Gln Pro Thr Thr Pro Val Ser Ser Phe Thr Ser Gly 
                165                 170                 175     


Ser Met Leu Gly Arg Thr Asp Thr Ala Leu Thr Asn Thr Tyr Ser Ala 
            180                 185                 190         


Leu Pro Pro Met Pro Ser Phe Thr Met Ala Asn Asn Leu Pro Met Gln 
        195                 200                 205             


Pro Pro Val Pro Ser Gln Thr Ser Ser Tyr Ser Cys Met Leu Pro Thr 
    210                 215                 220                 


Ser Pro Ser Val Asn Gly Arg Ser Tyr Asp Thr Tyr Thr Pro Pro His 
225                 230                 235                 240 


Met Gln Thr His Met Asn Ser Gln Pro Met Gly Thr Ser Gly Thr Thr 
                245                 250                 255     


Ser Thr Gly Leu Ile Ser Pro Gly Val Ser Val Pro Val Gln Val Pro 
            260                 265                 270         


Gly Ser Glu Pro Asp Met Ser Gln Tyr Trp Pro Arg Leu Gln 
        275                 280                 285     


<210> 42
<211> 6732
<212> DNA
<213> Homo sapiens

<400> 42
cttttcaatt agccttccat gcatgatccg gagcgacttc cgcctatttc cagaaattaa       60

gctcaaactt gacgtgcagc tagttttatt ttaaagacaa atgtcagaga ggctcatcat      120

attttccccc ctcttctata tttggagctt atttattgct aagaagctca ggctcctggc      180

gtcaatttat cagtaggctc caaggagaag agaggagagg agaggagagc tgaacaggga      240

gccacgtctt ttcctgggag ggctgctatc taagtcgggg ctgcaggtca cagcggagtg      300

aatcagctcg gtggtgtctt tgtcaacggg cggccactgc cggactccac ccggcagaag      360

attgtagagc tagctcacag cggggcccgg ccgtgcgaca tttcccgaat tctgcagacc      420

catgcagatg caaaagtcca agtgctggac aatcaaaacg tgtccaacgg atgtgtgagt      480

aaaattctgg gcaggtatta cgagactggc tccatcagac ccagggcaat cggtggtagt      540

aaaccgagag tagcgactcc agaagttgta agcaaaatag cccagtataa gcgggagtgc      600

ccgtccatct ttgcttggga aatccgagac agattactgt ccgagggggt ctgtaccaac      660

gataacatac caagcgtgtc atcaataaac agagttcttc gcaacctggc tagcgaaaag      720

caacagatgg gcgcagacgg catgtatgat aaactaagga tgttgaacgg gcagaccgga      780

agctggggca cccgccctgg ttggtatccg gggacttcgg tgccagggca acctacgcaa      840

gatggctgcc agcaacagga aggaggggga gagaatacca actccatcag ttccaacgga      900

gaagattcag atgaggctca aatgcgactt cagctgaagc ggaagctgca aagaaataga      960

acatccttta cccaagagca aattgaggcc ctggagaaag agtttgagag aacccattat     1020

ccagatgtgt ttgcccgaga aagactagca gccaaaatag atctacctga agcaagaata     1080

caggtatggt tttctaatcg aagggccaaa tggagaagag aagaaaaact gaggaatcag     1140

agaagacagg ccagcaacac acctagtcat attcctatca gcagtagttt cagcaccagt     1200

gtctaccaac caattccaca acccaccaca ccggtttcct ccttcacatc tggctccatg     1260

ttgggccgaa cagacacagc cctcacaaac acctacagcg ctctgccgcc tatgcccagc     1320

ttcaccatgg caaataacct gcctatgcaa cccccagtcc ccagccagac ctcctcatac     1380

tcctgcatgc tgcccaccag cccttcggtg aatgggcgga gttatgatac ctacaccccc     1440

ccacatatgc agacacacat gaacagtcag ccaatgggca cctcgggcac cacttcaaca     1500

ggactcattt cccctggtgt gtcagttcca gttcaagttc ccggaagtga acctgatatg     1560

tctcaatact ggccaagatt acagtaaaaa aaaaaaaaaa aaaaaaaagg aaaggaaata     1620

ttgtgttaat tcagtcagtg actatgggga cacaacagtt gagctttcag gaaagaaaga     1680

aaaatggctg ttagagccgc ttcagttcta caattgtgtc ctgtattgta ccactgggga     1740

aggaatggac ttgaaacaag gacctttgta tacagaaggc acgatatcag ttggaacaaa     1800

tcttcatttt ggtatccaaa cttttattca ttttggtgta ttatttgtaa atgggcattt     1860

gtatgttata atgaaaaaaa gaacaatgta gactggatgg atgtttgatc tgtgttggtc     1920

atgaagttgt tttttttttt tttaaaaaga aaaccatgat caacaagctt tgccacgaat     1980

ttaagagttt tatcaagata tatcgaatac ttctacccat ctgttcatag tttatggact     2040

gatgttccaa gtttgtatca ttcctttgca tataattaaa cctggaacaa catgcactag     2100

atttatgtca gaaatatctg ttggttttcc aaaggttgtt aacagatgaa gtttatgtgc     2160

aaaaaagggt aagatataaa ttcaaggaag aaaaaaagtt gatagctaaa aggtagagtg     2220

tgtcttcgat ataatccaat ttgttttatg tcaaaatgta agtatttgtc ttccctagaa     2280

atcctcagaa tgatttctat aataaagtta atttcattta tatttgacaa gaatatagat     2340

gttttataca cattttcatg caatcatacg tttctttttt ggccagcaaa agttaattgt     2400

tcttagatat agttgtatta ctgttcacgg tccaatcatt ttgtgcatct agagttcatt     2460

cctaatcaat taaaagtgct tgcaagagtt ttaaacttaa gtgttttgaa gttgttcaca     2520

actacatatc aaaattaacc attgttgatt gtaaaaaacc atgccaaagc ctttgtattt     2580

cctttattat acagttttct ttttaacctt atagtgtggt gttacaaatt ttatttccat     2640

gttagatcaa cattctaaac caatggttac tttcacacac actctgtttt acatcctgat     2700

gatccttaaa aaataatcct tatagatacc ataaatcaaa aacgtgttag aaaaaaattc     2760

cacttacagc agggtgtaga tctgtgccca tttataccca caacatatat acaaaatggt     2820

aacatttccc agttagccat ttaattctaa agctcaaagt ctagaaataa tttaaaaatg     2880

caacaagcga ttagctagga attgtttttt gaattaggac tggcattttc aatctgggca     2940

gatttccatt gtcagcctat ttcaacaatg atttcactga agtatattca aaagtagatt     3000

tcttaaagga gactttctga aagctgttgc ctttttcaaa taggccctct cccttttctg     3060

tctccctccc ctttgcacaa gaggcatcat ttcccattga accactacag ctgttcccat     3120

ttgaatcttg ctttctgtgc ggttgtggat ggttggaggg tggagggggg atgttgcatg     3180

tcaaggaata atgagcacag acacatcaac agacaacaac aaagcagact gtgactggcc     3240

ggtgggaatt aaaggccttc agtcattggc agcttaagcc aaacattccc aaatctatga     3300

agcagggccc attgttggtc agttgttatt tgcaatgaag cacagttctg atcatgttta     3360

aagtggaggc acgcagggca ggagtgcttg agcccaagca aaggatggaa aaaaataagc     3420

ctttgttggg taaaaaagga ctgtctgaga ctttcatttg ttctgtgcaa catataagtc     3480

aatacagata agtcttcctc tgcaaacttc actaaaaagc ctgggggttc tggcagtcta     3540

gattaaaatg cttgcacatg cagaaacctc tggggacaaa gacacacttc cactgaatta     3600

tactctgctt taaaaaaatc cccaaaagca aatgatcaga aatgtagaaa ttaatggaag     3660

gatttaaaca tgaccttctc gttcaatatc tactgttttt tagttaagga attacttgtg     3720

aacagataat tgagattcat tgctccggca tgaaatatac taataatttt attccaccag     3780

agttgctgca catttggaga caccttccta agttgcagtt tttgtatgtg tgcatgtagt     3840

tttgttcagt gtcagcctgc actgcacagc agcacatttc tgcaggggag tgagcacaca     3900

tacgcactgt tggtacaatt gccggtgcag acatttctac ctcctgacat tttgcagcct     3960

acattccctg agggctgtgt gctgagggaa ctgtcagaga agggctatgt gggagtgcat     4020

gccacagctg ctggctggct tacttcttcc ttctcgctgg ctgtaatttc caccacggtc     4080

aggcagccag ttccggccca cggttctgtt gtgtagacag cagagacttt ggagacccgg     4140

atgtcgcacg ccaggtgcaa gaggtgggaa tgggagaaaa ggagtgacgt gggagcggag     4200

ggtctgtatg tgtgcacttg ggcacgtata tgtgtgctct gaaggtcagg attgccaggg     4260

caaagtagca cagtctggta tagtctgaag aagcggctgc tcagctgcag aagccctctg     4320

gtccggcagg atgggaacgg ctgccttgcc ttctgcccac accctaggga catgagctgt     4380

ccttccaaac agagctccag gcactctctt ggggacagca tggcaggctc tgtgtggtag     4440

cagtgcctgg gagttggcct tttactcatt gttgaaataa tttttgttta ttatttattt     4500

aacgatacat atatttatat atttatcaat ggggtatctg cagggatgtt ttgacaccat     4560

cttccaggat ggagattatt tgtgaagact tcagtagaat cccaggacta aacgtctaaa     4620

ttttttctcc aaacttgact gacttgggaa aaccaggtga atagaataag agctgaatgt     4680

tttaagtaat aaacgttcaa actgctctaa gtaaaaaaat gcattttact gcaatgaatt     4740

tctagaatat ttttccccca aagctatgcc tcctaaccct taaatggtga acaactggtt     4800

tcttgctaca gctcactgcc atttcttctt actatcatca ctaggtttcc taagattcac     4860

tcatacagta ttatttgaag attcagcttt gttctgtgaa tgtcatctta ggattgtgtc     4920

tatattcttt tgcttatttc tttttactct gggcctctca tactagtaag attttaaaaa     4980

gccttttctt ctctgtatgt ttggctcacc aaggcgaaat atatattctt ctctttttca     5040

tttctcaaga ataaacctca tctgcttttt tgtttttctg tgttttggct tggtactgaa     5100

tgactcaact gctcggtttt aaagttcaaa gtgtaagtac ttagggttag tactgcttat     5160

ttcaataatg ttgacggtga ctatctttgg aaagcagtaa catgctgtct tagaaatgac     5220

attaataatg ggcttaaaca aatgaatagg ggggtccccc cactctcctt ttgtatgcct     5280

atgtgtgtct gatttgttaa aagatggaca gggaattgat tgcagagtgt cgcttccttc     5340

taaagtagtt ttattttgtc tactgttagt atttaaagat cctggaggtg gacataagga     5400

ataaatggaa gagaaaagta gatattgtat ggtggctact aaaaggaaat tcaaaaagtc     5460

ttagaacccg agcacctgag caaactgcag tagtcaaaat atttatctca tgttaaagaa     5520

aggcaaatct agtgtaagaa atgagtacca tatagggttt tgaagttcat atactagaaa     5580

cacttaaaag atatcatttc agatattacg tttggcattg ttcttaagta tttatatctt     5640

tgagtcaagc tgataattaa aaaaaatctg ttaatggagt gtatatttca taatgtatca     5700

aaatggtgtc tatacctaag gtagcattat tgaagagaga tatgtttatg tagtaagtta     5760

ttaacataat gagtaacaaa taatgtttcc agaagaaagg aaaacacatt ttcagagtgc     5820

gtttttatca gaggaagaca aaaatacaca cccctctcca gtagcttatt tttacaaagc     5880

cggcccagtg aattagaaaa acaaagcact tggatatgat ttttggaaag cccaggtaca     5940

cttattattc aaaatgcact tttactgagt ttgaaaagtt tcttttatat ttaaaataag     6000

ggttcaaata tgcatattca atttttatag tagttatcta tttgcaaagc atatattaac     6060

tagtaattgg ctgttaattt tatagacatg gtagccaggg aagtatatca atgacctatt     6120

aagtattttg acaagcaatt tacatatctg atgacctcgt atctcttttt cagcaagtca     6180

aatgctatgt aattgttcca ttgtgtgttg tataaaatga atcaacacgg taagaaaaag     6240

gttagagtta ttaaaataat aaactgacta aaatactcat ttgaatttat tcagaatgtt     6300

cataatgctt tcaaaggaca tagcagagct tttgtggagt atccgcacaa cattatttat     6360

tatctatgga ctaaatcaat tttttgaagt tgctttaaaa tttaaaagca cctttgctta     6420

atataaagcc ctttaatttt aactgacaga tcaattctga aactttattt tgaaaagaaa     6480

atggggaaga atctgtgtct ttagaattaa aagaaatgaa aaaaataaac ccgacattct     6540

aaaaaaatag aataagaaac ctgattttta gtactaatga aatagcgggt gacaaaatag     6600

ttgtcttttt gattttgatc acaaaaaata aactggtagt gacaggatat gatggagaga     6660

tttgacatcc tggcaaatca ctgtcattga ttcaattatt ctaattctga ataaaagctg     6720

tatacagtaa aa                                                         6732


<210> 43
<211> 283
<212> PRT
<213> Homo sapiens

<400> 43
Met Asn Gly Glu Glu Gln Tyr Tyr Ala Ala Thr Gln Leu Tyr Lys Asp 
1               5                   10                  15      


Pro Cys Ala Phe Gln Arg Gly Pro Ala Pro Glu Phe Ser Ala Ser Pro 
            20                  25                  30          


Pro Ala Cys Leu Tyr Met Gly Arg Gln Pro Pro Pro Pro Pro Pro His 
        35                  40                  45              


Pro Phe Pro Gly Ala Leu Gly Ala Leu Glu Gln Gly Ser Pro Pro Asp 
    50                  55                  60                  


Ile Ser Pro Tyr Glu Val Pro Pro Leu Ala Asp Asp Pro Ala Val Ala 
65                  70                  75                  80  


His Leu His His His Leu Pro Ala Gln Leu Ala Leu Pro His Pro Pro 
                85                  90                  95      


Ala Gly Pro Phe Pro Glu Gly Ala Glu Pro Gly Val Leu Glu Glu Pro 
            100                 105                 110         


Asn Arg Val Gln Leu Pro Phe Pro Trp Met Lys Ser Thr Lys Ala His 
        115                 120                 125             


Ala Trp Lys Gly Gln Trp Ala Gly Gly Ala Tyr Ala Ala Glu Pro Glu 
    130                 135                 140                 


Glu Asn Lys Arg Thr Arg Thr Ala Tyr Thr Arg Ala Gln Leu Leu Glu 
145                 150                 155                 160 


Leu Glu Lys Glu Phe Leu Phe Asn Lys Tyr Ile Ser Arg Pro Arg Arg 
                165                 170                 175     


Val Glu Leu Ala Val Met Leu Asn Leu Thr Glu Arg His Ile Lys Ile 
            180                 185                 190         


Trp Phe Gln Asn Arg Arg Met Lys Trp Lys Lys Glu Glu Asp Lys Lys 
        195                 200                 205             


Arg Gly Gly Gly Thr Ala Val Gly Gly Gly Gly Val Ala Glu Pro Glu 
    210                 215                 220                 


Gln Asp Cys Ala Val Thr Ser Gly Glu Glu Leu Leu Ala Leu Pro Pro 
225                 230                 235                 240 


Pro Pro Pro Pro Gly Gly Ala Val Pro Pro Ala Ala Pro Val Ala Ala 
                245                 250                 255     


Arg Glu Gly Arg Leu Pro Pro Gly Leu Ser Ala Ser Pro Gln Pro Ser 
            260                 265                 270         


Ser Val Ala Pro Arg Arg Pro Gln Glu Pro Arg 
        275                 280             


<210> 44
<211> 2573
<212> DNA
<213> Homo sapiens

<400> 44
gggtggcgcc gggagtggga acgccacaca gtgccaaatc cccggctcca gctcccgact       60

cccggctccc ggctcccggc tcccggtgcc caatcccggg ccgcagccat gaacggcgag      120

gagcagtact acgcggccac gcagctttac aaggacccat gcgcgttcca gcgaggcccg      180

gcgccggagt tcagcgccag cccccctgcg tgcctgtaca tgggccgcca gcccccgccg      240

ccgccgccgc acccgttccc tggcgccctg ggcgcgctgg agcagggcag ccccccggac      300

atctccccgt acgaggtgcc ccccctcgcc gacgaccccg cggtggcgca ccttcaccac      360

cacctcccgg ctcagctcgc gctcccccac ccgcccgccg ggcccttccc ggagggagcc      420

gagccgggcg tcctggagga gcccaaccgc gtccagctgc ctttcccatg gatgaagtct      480

accaaagctc acgcgtggaa aggccagtgg gcaggcggcg cctacgctgc ggagccggag      540

gagaacaagc ggacgcgcac ggcctacacg cgcgcacagc tgctagagct ggagaaggag      600

ttcctattca acaagtacat ctcacggccg cgccgggtgg agctggctgt catgttgaac      660

ttgaccgaga gacacatcaa gatctggttc caaaaccgcc gcatgaagtg gaaaaaggag      720

gaggacaaga agcgcggcgg cgggacagct gtcgggggtg gcggggtcgc ggagcctgag      780

caggactgcg ccgtgacctc cggcgaggag cttctggcgc tgccgccgcc gccgcccccc      840

ggaggtgctg tgccgcccgc tgcccccgtt gccgcccgag agggccgcct gccgcctggc      900

cttagcgcgt cgccacagcc ctccagcgtc gcgcctcggc ggccgcagga accacgatga      960

gaggcaggag ctgctcctgg ctgaggggct tcaaccactc gccgaggagg agcagagggc     1020

ctaggaggac cccgggcgtg gaccacccgc cctggcagtt gaatggggcg gcaattgcgg     1080

ggcccacctt agaccgaagg ggaaaacccg ctctctcagg cgcatgtgcc agttggggcc     1140

ccgcgggtag atgccggcag gccttccgga agaaaaagag ccattggttt ttgtagtatt     1200

ggggccctct tttagtgata ctggattggc gttgtttgtg gctgttgcgc acatccctgc     1260

cctcctacag cactccacct tgggacctgt ttagagaagc cggctcttca aagacaatgg     1320

aaactgtacc atacacattg gaaggctccc taacacacac agcggggaag ctgggccgag     1380

taccttaatc tgccataaag ccattcttac tcgggcgacc cctttaagtt tagaaataat     1440

tgaaaggaaa tgtttgagtt ttcaaagatc ccgtgaaatt gatgccagtg gaatacagtg     1500

agtcctcctc ttcctcctcc tcctcttccc cctccccttc ctcctcctcc tcttcttttc     1560

cctcctcttc ctcttcctcc tgctctcctt tcctccccct cctcttttcc ctcctcttcc     1620

tcttcctcct gctctccttt cctccccctc ctctttctcc tcctcctcct cttcttcccc     1680

ctcctctccc tcctcctctt cttccccctc ctctccctcc tcctcttctt ctccctcctc     1740

ttcctcttcc tcctcttcca cgtgctctcc tttcctcccc ctcctcttgc tccccttctt     1800

ccccgtcctc ttcctcctcc tcctcttctt ctccctcctc ttcctcctcc tctttcttcc     1860

tgacctcttt ctttctcctc ctcctccttc tacctcccct tctcatccct cctcttcctc     1920

ttctctagct gcacacttca ctactgcaca tcttataact tgcacccctt tcttctgagg     1980

aagagaacat cttgcaaggc agggcgagca gcggcagggc tggcttagga gcagtgcaag     2040

agtccctgtg ctccagttcc acactgctgg cagggaaggc aaggggggac gggcctggat     2100

ctgggggtga gggagaaaga tggacccctg ggtgaccact aaaccaaaga tattcggaac     2160

tttctattta ggatgtggac gtaattcctg ttccgaggta gaggctgtgc tgaagacaag     2220

cacagtggcc tggtgcgcct tggaaaccaa caactattca cgagccagta tgaccttcac     2280

atctttagaa attatgaaaa cgtatgtgat tggagggttt ggaaaaccag ttatcttatt     2340

taacatttta aaaattacct aacagttatt tacaaacagg tctgtgcatc ccaggtctgt     2400

cttcttttca aggtctgggc cttgtgctcg ggttatgttt gtgggaaatg cttaataaat     2460

actgataata tgggaagaga tgaaaactga ttctcctcac tttgtttcaa acctttctgg     2520

cagtgggatg attcgaattc acttttaaaa ttaaattagc gtgttttgtt ttg            2573


<210> 45
<211> 328
<212> PRT
<213> Homo sapiens

<400> 45
Met Asp Ala Val Leu Leu Glu His Phe Pro Gly Gly Leu Asp Ala Phe 
1               5                   10                  15      


Pro Ser Ser Tyr Phe Asp Glu Asp Asp Phe Phe Thr Asp Gln Ser Ser 
            20                  25                  30          


Arg Asp Pro Leu Glu Asp Gly Asp Glu Leu Leu Ala Asp Glu Gln Ala 
        35                  40                  45              


Glu Val Glu Phe Leu Ser His Gln Leu His Glu Tyr Cys Tyr Arg Asp 
    50                  55                  60                  


Gly Ala Cys Leu Leu Leu Gln Pro Ala Pro Pro Ala Ala Pro Leu Ala 
65                  70                  75                  80  


Leu Ala Pro Pro Ser Ser Gly Gly Leu Gly Glu Pro Asp Asp Gly Gly 
                85                  90                  95      


Gly Gly Gly Tyr Cys Cys Glu Thr Gly Ala Pro Pro Gly Gly Phe Pro 
            100                 105                 110         


Tyr Ser Pro Gly Ser Pro Pro Ser Cys Leu Ala Tyr Pro Cys Ala Gly 
        115                 120                 125             


Ala Ala Val Leu Ser Pro Gly Ala Arg Leu Arg Gly Leu Ser Gly Ala 
    130                 135                 140                 


Ala Ala Ala Ala Ala Arg Arg Arg Arg Arg Val Arg Ser Glu Ala Glu 
145                 150                 155                 160 


Leu Gln Gln Leu Arg Gln Ala Ala Asn Val Arg Glu Arg Arg Arg Met 
                165                 170                 175     


Gln Ser Ile Asn Asp Ala Phe Glu Gly Leu Arg Ser His Ile Pro Thr 
            180                 185                 190         


Leu Pro Tyr Glu Lys Arg Leu Ser Lys Val Asp Thr Leu Arg Leu Ala 
        195                 200                 205             


Ile Gly Tyr Ile Asn Phe Leu Ser Glu Leu Val Gln Ala Asp Leu Pro 
    210                 215                 220                 


Leu Arg Gly Gly Gly Ala Gly Gly Cys Gly Gly Pro Gly Gly Gly Gly 
225                 230                 235                 240 


Arg Leu Gly Gly Asp Ser Pro Gly Ser Gln Ala Gln Lys Val Ile Ile 
                245                 250                 255     


Cys His Arg Gly Thr Arg Ser Pro Ser Pro Ser Asp Pro Asp Tyr Gly 
            260                 265                 270         


Leu Pro Pro Leu Ala Gly His Ser Leu Ser Trp Thr Asp Glu Lys Gln 
        275                 280                 285             


Leu Lys Glu Gln Asn Ile Ile Arg Thr Ala Lys Val Trp Thr Pro Glu 
    290                 295                 300                 


Asp Pro Arg Lys Leu Asn Ser Lys Ser Ser Phe Asn Asn Ile Glu Asn 
305                 310                 315                 320 


Glu Pro Pro Phe Glu Phe Val Ser 
                325             


<210> 46
<211> 1339
<212> DNA
<213> Homo sapiens

<400> 46
atggacgcgg tgttgctgga gcacttcccc gggggcctag acgcctttcc ttcttcgtac       60

ttcgacgagg acgacttctt caccgaccag tcttcacggg accccctgga ggacggcgat      120

gagctgctgg cggacgagca ggccgaggtg gagttcctta gccaccagct ccacgagtac      180

tgctaccgcg acggggcgtg cctgctgctg cagcccgcgc ccccggccgc cccgctagcg      240

ctcgccccgc cgtcctcggg gggcctcggt gagccagacg acggcggcgg cggcggctac      300

tgctgcgaga cgggggcgcc cccaggcggc ttcccctact cgcccggctc gccgccctcg      360

tgcctggcct acccgtgcgc cggggcggca gtactgtctc ccggggcgcg gctgcgcggc      420

ctgagcggag cggcggctgc ggcggcgcgg cgccggcggc gggtgcgctc cgaggcggag      480

ctgcagcagc tgcggcaggc ggccaacgtg cgcgagcggc ggcgcatgca gtccatcaac      540

gacgccttcg aggggctgcg ctcgcacatc cccacgctgc cctacgagaa gcgcctctcc      600

aaggtggaca cgctgcgcct ggccatcggc tacatcaact tcctcagcga gctcgtgcag      660

gccgacctgc ccttgcgcgg cggtggcgcg ggcggctgcg gggggccggg cggcggcggg      720

cgcctgggcg gggacagccc gggcagccag gcccagaagg tcatcatctg ccatcggggc      780

acccggtccc cctcccccag cgaccctgat tatggcctcc ctcccctagc aggacactct      840

ctctcatgga ctgatgaaaa acaactcaag gaacaaaata ttatccgaac agccaaagtc      900

tggaccccag aggaccccag aaaactcaac agcaaatctt ccttcaacaa catagaaaac      960

gaaccaccat ttgagtttgt gtcctgagaa gtcccagact cggctgaaga tctgattatg     1020

tctctgtgca tattgtacat gtaaatatct ataatgtaaa tgtaatttaa gaatcaaatt     1080

tttcgaatgg caatcaactg tttattattt atctatttat tatcctgttg agttgatgaa     1140

atagatgatt tctttttaaa tatataattt atataactta tcctgatttt ctgaaaatat     1200

gcaatagcct atgattttcc tgaactctgt gttgttggga gaactctggc cagaaaacgt     1260

cctgcttatt tattgccaga tatggtttat ttctaagcgt tgtcaataaa tgctatttac     1320

accttttcct gaaaaaaaa                                                  1339


<210> 47
<211> 1555
<212> DNA
<213> Homo sapiens

<400> 47
cggcgatggc cccactcgga tacttcttac tcctctgcag cctgaagcag gctctgggca       60

gctacccgat ctggtggtcg ctggctgttg ggccacagta ttcctccctg ggctcgcagc      120

ccatcctgtg tgccagcatc ccgggcctgg tccccaagca gctccgcttc tgcaggaact      180

acgtggagat catgcccagc gtggccgagg gcatcaagat tggcatccag gagtgccagc      240

accagttccg cggccgccgg tggaactgca ccaccgtcca cgacagcctg gccatcttcg      300

ggcccgtgct ggacaaagct accagggagt cggcctttgt ccacgccatt gcctcagccg      360

gtgtggcctt tgcagtgaca cgctcatgtg cagaaggcac ggccgccatc tgtggctgca      420

gcagccgcca ccagggctca ccaggcaagg gctggaagtg gggtggctgt agcgaggaca      480

tcgagtttgg tgggatggtg tctcgggagt tcgccgacgc ccgggagaac cggccagatg      540

cccgctcagc catgaaccgc cacaacaacg aggctgggcg ccaggccatc gccagccaca      600

tgcacctcaa gtgcaagtgc cacgggctgt cgggcagctg cgaggtgaag acatgctggt      660

ggtcgcaacc cgacttccgc gccatcggtg acttcctcaa ggacaagtac gacagcgcct      720

cggagatggt ggtggagaag caccgggagt cccgcggctg ggtggagacc ctgcggccgc      780

gctacaccta cttcaaggtg cccacggagc gcgacctggt ctactacgag gcctcgccca      840

acttctgcga gcccaaccct gagacgggct ccttcggcac gcgcgaccgc acctgcaacg      900

tcagctcgca cggcatcgac ggctgcgacc tgctgtgctg cggccgcggc cacaacgcgc      960

gagcggagcg gcgccgggag aagtgccgct gcgtgttcca ctggtgctgc tacgtcagct     1020

gccaggagtg cacgcgcgtc tacgacgtgc acacctgcaa gtaggcaccg gccgcggctc     1080

cccctggacg gggcgggccc tgcctgaggg tgggcttttc cctgggtgga gcaggactcc     1140

cacctaaacg gggcagtact cctccctggg ggcgggactc ctccctgggg gtggggctcc     1200

tacctggggg cagaactcct acctgaaggc agggctcctc cctggagcta gtgtctcctc     1260

tctggtggct gggctgctcc tgaatgaggc ggagctccag gatggggagg ggctctgcgt     1320

tggcttctcc ctggggacgg ggctcccctg gacagaggcg gggctacaga ttgggcgggg     1380

cttctcttgg gtgggacagg gcttctcctg cgggggcgag gcccctccca gtaagggcgt     1440

ggctctgggt gggcggggca ctaggtaggc ttctacctgc aggcggggct cctcctgaag     1500

gaggcggggc tctaggatgg ggcacggctc tggggtaggc tgctccctga gggcg          1555


<210> 48
<211> 385
<212> PRT
<213> Homo sapiens

<400> 48
Met Ala Pro Leu Gly Tyr Phe Leu Leu Leu Cys Ser Leu Lys Gln Ala 
1               5                   10                  15      


Leu Gly Ser Tyr Pro Ile Trp Trp Ser Leu Ala Val Gly Pro Gln Tyr 
            20                  25                  30          


Ser Ser Leu Gly Ser Gln Pro Ile Leu Cys Ala Ser Ile Pro Gly Leu 
        35                  40                  45              


Val Pro Lys Gln Leu Arg Phe Cys Arg Asn Tyr Val Glu Ile Met Pro 
    50                  55                  60                  


Ser Val Ala Glu Gly Ile Lys Ile Gly Ile Gln Glu Cys Gln His Gln 
65                  70                  75                  80  


Phe Arg Gly Arg Arg Trp Asn Cys Thr Thr Val His Asp Ser Leu Ala 
                85                  90                  95      


Ile Phe Gly Pro Val Leu Asp Lys Ala Thr Arg Glu Ser Ala Phe Val 
            100                 105                 110         


His Ala Ile Ala Ser Ala Gly Val Ala Phe Ala Val Thr Arg Ser Cys 
        115                 120                 125             


Ala Glu Gly Thr Ala Ala Ile Cys Gly Cys Ser Ser Arg His Gln Gly 
    130                 135                 140                 


Ser Pro Gly Lys Gly Trp Lys Trp Gly Gly Cys Ser Glu Asp Ile Glu 
145                 150                 155                 160 


Phe Gly Gly Met Val Ser Arg Glu Phe Ala Asp Ala Arg Glu Asn Arg 
                165                 170                 175     


Pro Asp Ala Arg Ser Ala Met Asn Arg His Asn Asn Glu Ala Gly Arg 
            180                 185                 190         


Gln Ala Ile Ala Ser His Met His Leu Lys Cys Lys Cys His Gly Leu 
        195                 200                 205             


Ser Gly Ser Cys Glu Val Lys Thr Cys Trp Trp Ser Gln Pro Asp Phe 
    210                 215                 220                 


Arg Ala Ile Gly Asp Phe Leu Lys Asp Lys Tyr Asp Ser Ala Ser Glu 
225                 230                 235                 240 


Met Val Val Glu Lys His Arg Glu Ser Arg Gly Trp Val Glu Thr Leu 
                245                 250                 255     


Arg Pro Arg Tyr Thr Tyr Phe Lys Val Pro Thr Glu Arg Asp Leu Val 
            260                 265                 270         


Tyr Tyr Glu Ala Ser Pro Asn Phe Cys Glu Pro Asn Pro Glu Thr Gly 
        275                 280                 285             


Ser Phe Gly Thr Arg Asp Arg Thr Cys Asn Val Ser Ser His Gly Ile 
    290                 295                 300                 


Asp Gly Cys Asp Leu Leu Cys Cys Gly Arg Gly His Asn Ala Arg Ala 
305                 310                 315                 320 


Glu Arg Arg Arg Glu Lys Cys Arg Cys Val Phe His Trp Cys Cys Tyr 
                325                 330                 335     


Val Ser Cys Gln Glu Cys Thr Arg Val Tyr Asp Val His Thr Cys Lys 
            340                 345                 350         


Asn Pro Gly Ser Arg Ala Gly Asn Ser Ala His Gln Pro Pro His Pro 
        355                 360                 365             


Gln Pro Pro Val Arg Phe His Pro Pro Leu Arg Arg Ala Gly Lys Val 
    370                 375                 380                 


Pro 
385 


<210> 49
<211> 1056
<212> DNA
<213> Homo sapiens

<400> 49
atgagtcccc gctcgtgcct gcgttcgctg cgcctcctcg tcttcgccgt cttctcagcc       60

gccgcgagca actggctgta cctggccaag ctgtcgtcgg tggggagcat ctcagaggag      120

gagacgtgcg agaaactcaa gggcctgatc cagaggcagg tgcagatgtg caagcggaac      180

ctggaagtca tggactcggt gcgccgcggt gcccagctgg ccattgagga gtgccagtac      240

cagttccgga accggcgctg gaactgctcc acactcgact ccttgcccgt cttcggcaag      300

gtggtgacgc aagggattcg ggaggcggcc ttggtgtacg ccatctcttc ggcaggtgtg      360

gcctttgcag tgacgcgggc gtgcagcagt ggggagctgg agaagtgcgg ctgtgacagg      420

acagtgcatg gggtcagccc acagggcttc cagtggtcag gatgctctga caacatcgcc      480

tacggtgtgg ccttctcaca gtcgtttgtg gatgtgcggg agagaagcaa gggggcctcg      540

tccagcagag ccctcatgaa cctccacaac aatgaggccg gcaggaaggc catcctgaca      600

cacatgcggg tggaatgcaa gtgccacggg gtgtcaggct cctgtgaggt aaagacgtgc      660

tggcgagccg tgccgccctt ccgccaggtg ggtcacgcac tgaaggagaa gtttgatggt      720

gccactgagg tggagccacg ccgcgtgggc tcctccaggg cactggtgcc acgcaacgca      780

cagttcaagc cgcacacaga tgaggacttg gtgtacttgg agcctagccc cgacttctgt      840

gagcaggaca tgcgcagcgg cgtgctgggc acgaggggcc gcacatgcaa caagacgtcc      900

aaggccatcg acggctgtga gctgctgtgc tgtggccgcg gcttccacac ggcgcaggtg      960

gagctggctg aacgctgcag ctgcaaattc cactggtgct gcttcgtcaa gtgccggcag     1020

tgccagcggc tcgtggagtt gcacacgtgc cgatga                               1056


<210> 50
<211> 351
<212> PRT
<213> Homo sapiens

<400> 50
Met Ser Pro Arg Ser Cys Leu Arg Ser Leu Arg Leu Leu Val Phe Ala 
1               5                   10                  15      


Val Phe Ser Ala Ala Ala Ser Asn Trp Leu Tyr Leu Ala Lys Leu Ser 
            20                  25                  30          


Ser Val Gly Ser Ile Ser Glu Glu Glu Thr Cys Glu Lys Leu Lys Gly 
        35                  40                  45              


Leu Ile Gln Arg Gln Val Gln Met Cys Lys Arg Asn Leu Glu Val Met 
    50                  55                  60                  


Asp Ser Val Arg Arg Gly Ala Gln Leu Ala Ile Glu Glu Cys Gln Tyr 
65                  70                  75                  80  


Gln Phe Arg Asn Arg Arg Trp Asn Cys Ser Thr Leu Asp Ser Leu Pro 
                85                  90                  95      


Val Phe Gly Lys Val Val Thr Gln Gly Ile Arg Glu Ala Ala Leu Val 
            100                 105                 110         


Tyr Ala Ile Ser Ser Ala Gly Val Ala Phe Ala Val Thr Arg Ala Cys 
        115                 120                 125             


Ser Ser Gly Glu Leu Glu Lys Cys Gly Cys Asp Arg Thr Val His Gly 
    130                 135                 140                 


Val Ser Pro Gln Gly Phe Gln Trp Ser Gly Cys Ser Asp Asn Ile Ala 
145                 150                 155                 160 


Tyr Gly Val Ala Phe Ser Gln Ser Phe Val Asp Val Arg Glu Arg Ser 
                165                 170                 175     


Lys Gly Ala Ser Ser Ser Arg Ala Leu Met Asn Leu His Asn Asn Glu 
            180                 185                 190         


Ala Gly Arg Lys Ala Ile Leu Thr His Met Arg Val Glu Cys Lys Cys 
        195                 200                 205             


His Gly Val Ser Gly Ser Cys Glu Val Lys Thr Cys Trp Arg Ala Val 
    210                 215                 220                 


Pro Pro Phe Arg Gln Val Gly His Ala Leu Lys Glu Lys Phe Asp Gly 
225                 230                 235                 240 


Ala Thr Glu Val Glu Pro Arg Arg Val Gly Ser Ser Arg Ala Leu Val 
                245                 250                 255     


Pro Arg Asn Ala Gln Phe Lys Pro His Thr Asp Glu Asp Leu Val Tyr 
            260                 265                 270         


Leu Glu Pro Ser Pro Asp Phe Cys Glu Gln Asp Met Arg Ser Gly Val 
        275                 280                 285             


Leu Gly Thr Arg Gly Arg Thr Cys Asn Lys Thr Ser Lys Ala Ile Asp 
    290                 295                 300                 


Gly Cys Glu Leu Leu Cys Cys Gly Arg Gly Phe His Thr Ala Gln Val 
305                 310                 315                 320 


Glu Leu Ala Glu Arg Cys Ser Cys Lys Phe His Trp Cys Cys Phe Val 
                325                 330                 335     


Lys Cys Arg Gln Cys Gln Arg Leu Val Glu Leu His Thr Cys Arg 
            340                 345                 350     


<210> 51
<211> 1143
<212> DNA
<213> Homo sapiens

<400> 51
atgaagaagt ccattggaat attaagccca ggagttgctt tggggatggc tggaagtgca       60

atgtcttcca agttcttcct agtggctttg gccatatttt tctccttcgc ccaggttgta      120

attgaagcca attcttggtg gtcgctaggt atgaataacc ctgttcagat gtcagaagta      180

tatattatag gagcacagcc tctctgcagc caactggcag gactttctca aggacagaag      240

aaactgtgcc acttgtatca ggaccacatg cagtacatcg gagaaggcgc gaagacaggc      300

atcaaagaat gccagtatca attccgacat cgaaggtgga actgcagcac tgtggataac      360

acctctgttt ttggcagggt gatgcagata ggcagccgcg agacggcctt cacatacgcg      420

gtgagcgcag caggggtggt gaacgccatg agccgggcgt gccgcgaggg cgagctgtcc      480

acctgcggct gcagccgcgc cgcgcgcccc aaggacctgc cgcgggactg gctctggggc      540

ggctgcggcg acaacatcga ctatggctac cgctttgcca aggagttcgt ggacgcccgc      600

gagcgggagc gcatccacgc caagggctcc tacgagagtg ctcgcatcct catgaacctg      660

cacaacaacg aggccggccg caggacggtg tacaacctgg ctgatgtggc ctgcaagtgc      720

catggggtgt ccggctcatg tagcctgaag acatgctggc tgcagctggc agacttccgc      780

aaggtgggtg atgccctgaa ggagaagtac gacagcgcgg cggccatgcg gctcaacagc      840

cggggcaagt tggtacaggt caacagccgc ttcaactcgc ccaccacaca agacctggtc      900

tacatcgacc ccagccctga ctactgcgtg cgcaatgaga gcaccggctc gctgggcacg      960

cagggccgcc tgtgcaacaa gacgtcggag ggcatggatg gctgcgagct catgtgctgc     1020

ggccgtggct acgaccagtt caagaccgtg cagacggagc gctgccactg caagttccac     1080

tggtgctgct acgtcaagtg caagaagtgc acggagatcg tggaccagtt tgtgtgcaag     1140

tag                                                                   1143


<210> 52
<211> 380
<212> PRT
<213> Homo sapiens

<400> 52
Met Lys Lys Ser Ile Gly Ile Leu Ser Pro Gly Val Ala Leu Gly Met 
1               5                   10                  15      


Ala Gly Ser Ala Met Ser Ser Lys Phe Phe Leu Val Ala Leu Ala Ile 
            20                  25                  30          


Phe Phe Ser Phe Ala Gln Val Val Ile Glu Ala Asn Ser Trp Trp Ser 
        35                  40                  45              


Leu Gly Met Asn Asn Pro Val Gln Met Ser Glu Val Tyr Ile Ile Gly 
    50                  55                  60                  


Ala Gln Pro Leu Cys Ser Gln Leu Ala Gly Leu Ser Gln Gly Gln Lys 
65                  70                  75                  80  


Lys Leu Cys His Leu Tyr Gln Asp His Met Gln Tyr Ile Gly Glu Gly 
                85                  90                  95      


Ala Lys Thr Gly Ile Lys Glu Cys Gln Tyr Gln Phe Arg His Arg Arg 
            100                 105                 110         


Trp Asn Cys Ser Thr Val Asp Asn Thr Ser Val Phe Gly Arg Val Met 
        115                 120                 125             


Gln Ile Gly Ser Arg Glu Thr Ala Phe Thr Tyr Ala Val Ser Ala Ala 
    130                 135                 140                 


Gly Val Val Asn Ala Met Ser Arg Ala Cys Arg Glu Gly Glu Leu Ser 
145                 150                 155                 160 


Thr Cys Gly Cys Ser Arg Ala Ala Arg Pro Lys Asp Leu Pro Arg Asp 
                165                 170                 175     


Trp Leu Trp Gly Gly Cys Gly Asp Asn Ile Asp Tyr Gly Tyr Arg Phe 
            180                 185                 190         


Ala Lys Glu Phe Val Asp Ala Arg Glu Arg Glu Arg Ile His Ala Lys 
        195                 200                 205             


Gly Ser Tyr Glu Ser Ala Arg Ile Leu Met Asn Leu His Asn Asn Glu 
    210                 215                 220                 


Ala Gly Arg Arg Thr Val Tyr Asn Leu Ala Asp Val Ala Cys Lys Cys 
225                 230                 235                 240 


His Gly Val Ser Gly Ser Cys Ser Leu Lys Thr Cys Trp Leu Gln Leu 
                245                 250                 255     


Ala Asp Phe Arg Lys Val Gly Asp Ala Leu Lys Glu Lys Tyr Asp Ser 
            260                 265                 270         


Ala Ala Ala Met Arg Leu Asn Ser Arg Gly Lys Leu Val Gln Val Asn 
        275                 280                 285             


Ser Arg Phe Asn Ser Pro Thr Thr Gln Asp Leu Val Tyr Ile Asp Pro 
    290                 295                 300                 


Ser Pro Asp Tyr Cys Val Arg Asn Glu Ser Thr Gly Ser Leu Gly Thr 
305                 310                 315                 320 


Gln Gly Arg Leu Cys Asn Lys Thr Ser Glu Gly Met Asp Gly Cys Glu 
                325                 330                 335     


Leu Met Cys Cys Gly Arg Gly Tyr Asp Gln Phe Lys Thr Val Gln Thr 
            340                 345                 350         


Glu Arg Cys His Cys Lys Phe His Trp Cys Cys Tyr Val Lys Cys Lys 
        355                 360                 365             


Lys Cys Thr Glu Ile Val Asp Gln Phe Val Cys Lys 
    370                 375                 380 


