                         SEQUENCE LISTING

<110>  Merck Sharp & Dohme Corp.
       Lin, Songnian
       Yan, Lin
       Huo, Pei
       Pissarnitski, Dmitri
       Feng, Danqing
       Nargund, Ravi
       Zhu, Yuping
       Kekec, Ahmet
       Madsen-Duggan, Christina 
       Wu, Zhicai
 
<120>  INSULIN RECEPTOR PARTIAL AGONISTS

<130>  24335

<150>  62/341,171
<151>  2016-05-25

<160>  11    

<170>  PatentIn version 3.5

<210>  1
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  1

Gly Ile Val Glu Gln Cys Cys Thr Ser Ile Cys Ser Leu Tyr Gln Leu 
1               5                   10                  15      


Glu Asn Tyr Cys Asn 
            20      


<210>  2
<211>  30
<212>  PRT
<213>  Homo sapiens

<400>  2

Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      


Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr Thr Pro Lys Thr 
            20                  25                  30  


<210>  3
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Insulin A chain mutiens


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is isoleucine or threonine

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is valine, glycine, or leucine

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa is threonine or histidine

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  Xaa is glutamic acid or glutamine

<220>
<221>  MISC_FEATURE
<222>  (19)..(19)
<223>  Xaa is tyrosine, 4-methoxy-phenylalanine, alanine, or 4-amino 
       phenylalanine

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (23)..(23)
<223>  Xaa is asparagine or glycine

<400>  3

Gly Xaa Xaa Glu Gln Cys Cys Xaa Ser Ile Cys Ser Leu Tyr Gln Leu 
1               5                   10                  15      


Xaa Asn Xaa Cys Xaa 
            20      


<210>  4
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Insulin B chain variants


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is histidine or threonine

<220>
<221>  MISC_FEATURE
<222>  (1)..(25)
<223>  With the proviso that at least one of 24 or 25 is lysine

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa is alanine, glycine, or serine

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa is histidine, aspartic acid, glutamic acid, homocysteic acid,
       or cysteic acid

<220>
<221>  MISC_FEATURE
<222>  (21)..(21)
<223>  Xaa is proline or lysine

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Xaa is proline or lysine

<220>
<221>  MISC_FEATURE
<222>  (25)..(25)
<223>  Xaa is proline or lysine

<400>  4

Xaa Leu Cys Gly Xaa Xaa Leu Val Glu Ala Leu Tyr Leu Val Cys Gly 
1               5                   10                  15      


Glu Arg Gly Phe Xaa Tyr Thr Xaa Xaa 
            20                  25  


<210>  5
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Insulin B chain variants


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is phenylalanine or desamino-phenylalanine

<220>
<221>  MISC_FEATURE
<222>  (1)..(32)
<223>  With the proviso that at least one of 28 or 29 is lysine

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa is histidine or threonine

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa is glycine or leucine

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa is alanine, glycine, or serine

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa is histidine, aspartic acid, glutamic acid, homocysteic acid,
       or cysteic acid

<220>
<221>  MISC_FEATURE
<222>  (25)..(25)
<223>  Xaa is phenyalanine or aspartic acid

<220>
<221>  MISC_FEATURE
<222>  (28)..(28)
<223>  Xaa is aspartic acid, proline, or lysine

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  Xaa is lysine or proline

<220>
<221>  MISC_FEATURE
<222>  (30)..(30)
<223>  Xaa is threonine, alanine, or absent

<220>
<221>  MISC_FEATURE
<222>  (31)..(31)
<223>  Xaa is arginine or absent

<220>
<221>  MISC_FEATURE
<222>  (32)..(32)
<223>  Xaa is arginine or absent

<400>  5

Xaa Val Asn Gln Xaa Xaa Cys Gly Xaa Xaa Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      


Leu Val Cys Gly Glu Arg Gly Phe Xaa Tyr Thr Xaa Xaa Xaa Xaa Xaa 
            20                  25                  30          


<210>  6
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Insulin lispro B chain

<400>  6

Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      


Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr Thr Lys Pro Thr 
            20                  25                  30  


<210>  7
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Insulin glargine A chain

<400>  7

Gly Ile Val Glu Gln Cys Cys Thr Ser Ile Cys Ser Leu Tyr Gln Leu 
1               5                   10                  15      


Glu Asn Tyr Cys Gly 
            20      


<210>  8
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Insulin glargine B chain

<400>  8

Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      


Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr Thr Pro Lys Thr Arg Arg 
            20                  25                  30          


<210>  9
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Insulin aspart B chain

<400>  9

Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      


Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr Thr Asp Lys Thr 
            20                  25                  30  


<210>  10
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Des30 B chain

<400>  10

Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      


Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr Thr Pro Lys 
            20                  25                  


<210>  11
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A chain Y19A

<400>  11

Gly Ile Val Glu Gln Cys Cys Thr Ser Ile Cys Ser Leu Tyr Gln Leu 
1               5                   10                  15      


Glu Asn Ala Cys Asn 
            20      


