                         SEQUENCE LISTING

<110>  Oxford Nanopore Technologies Limited
 
<120>  METHOD

<130>  N408272WO

<140>  TBC
<141>  2017-05-25

<150>  GB 1609220.7
<151>  2016-05-25

<160>  122   

<170>  PatentIn version 3.5

<210>  1
<211>  558
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Mycobacterium smegmatis porin A mutant 
       (D90N/D91N/D93N/D118R/D134R/E139K)

<400>  1
atgggtctgg ataatgaact gagcctggtg gacggtcaag atcgtaccct gacggtgcaa       60

caatgggata cctttctgaa tggcgttttt ccgctggatc gtaatcgcct gacccgtgaa      120

tggtttcatt ccggtcgcgc aaaatatatc gtcgcaggcc cgggtgctga cgaattcgaa      180

ggcacgctgg aactgggtta tcagattggc tttccgtggt cactgggcgt tggtatcaac      240

ttctcgtaca ccacgccgaa tattctgatc aacaatggta acattaccgc accgccgttt      300

ggcctgaaca gcgtgattac gccgaacctg tttccgggtg ttagcatctc tgcccgtctg      360

ggcaatggtc cgggcattca agaagtggca acctttagtg tgcgcgtttc cggcgctaaa      420

ggcggtgtcg cggtgtctaa cgcccacggt accgttacgg gcgcggccgg cggtgtcctg      480

ctgcgtccgt tcgcgcgcct gattgcctct accggcgaca gcgttacgac ctatggcgaa      540

ccgtggaata tgaactaa                                                    558


<210>  2
<211>  184
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mycobacterium smegmatis porin A mutant 
       (D90N/D91N/D93N/D118R/D134R/E139K)

<400>  2

Gly Leu Asp Asn Glu Leu Ser Leu Val Asp Gly Gln Asp Arg Thr Leu 
1               5                   10                  15      


Thr Val Gln Gln Trp Asp Thr Phe Leu Asn Gly Val Phe Pro Leu Asp 
            20                  25                  30          


Arg Asn Arg Leu Thr Arg Glu Trp Phe His Ser Gly Arg Ala Lys Tyr 
        35                  40                  45              


Ile Val Ala Gly Pro Gly Ala Asp Glu Phe Glu Gly Thr Leu Glu Leu 
    50                  55                  60                  


Gly Tyr Gln Ile Gly Phe Pro Trp Ser Leu Gly Val Gly Ile Asn Phe 
65                  70                  75                  80  


Ser Tyr Thr Thr Pro Asn Ile Leu Ile Asn Asn Gly Asn Ile Thr Ala 
                85                  90                  95      


Pro Pro Phe Gly Leu Asn Ser Val Ile Thr Pro Asn Leu Phe Pro Gly 
            100                 105                 110         


Val Ser Ile Ser Ala Arg Leu Gly Asn Gly Pro Gly Ile Gln Glu Val 
        115                 120                 125             


Ala Thr Phe Ser Val Arg Val Ser Gly Ala Lys Gly Gly Val Ala Val 
    130                 135                 140                 


Ser Asn Ala His Gly Thr Val Thr Gly Ala Ala Gly Gly Val Leu Leu 
145                 150                 155                 160 


Arg Pro Phe Ala Arg Leu Ile Ala Ser Thr Gly Asp Ser Val Thr Thr 
                165                 170                 175     


Tyr Gly Glu Pro Trp Asn Met Asn 
            180                 


<210>  3
<211>  885
<212>  DNA
<213>  Artificial sequence

<220>
<223>  alpha-hemolysin mutant E111N/K147N

<400>  3
atggcagatt ctgatattaa tattaaaacc ggtactacag atattggaag caatactaca       60

gtaaaaacag gtgatttagt cacttatgat aaagaaaatg gcatgcacaa aaaagtattt      120

tatagtttta tcgatgataa aaatcacaat aaaaaactgc tagttattag aacaaaaggt      180

accattgctg gtcaatatag agtttatagc gaagaaggtg ctaacaaaag tggtttagcc      240

tggccttcag cctttaaggt acagttgcaa ctacctgata atgaagtagc tcaaatatct      300

gattactatc caagaaattc gattgataca aaaaactata tgagtacttt aacttatgga      360

ttcaacggta atgttactgg tgatgataca ggaaaaattg gcggccttat tggtgcaaat      420

gtttcgattg gtcatacact gaactatgtt caacctgatt tcaaaacaat tttagagagc      480

ccaactgata aaaaagtagg ctggaaagtg atatttaaca atatggtgaa tcaaaattgg      540

ggaccatacg atcgagattc ttggaacccg gtatatggca atcaactttt catgaaaact      600

agaaatggtt ctatgaaagc agcagataac ttccttgatc ctaacaaagc aagttctcta      660

ttatcttcag ggttttcacc agacttcgct acagttatta ctatggatag aaaagcatcc      720

aaacaacaaa caaatataga tgtaatatac gaacgagttc gtgatgatta ccaattgcat      780

tggacttcaa caaattggaa aggtaccaat actaaagata aatggacaga tcgttcttca      840

gaaagatata aaatcgattg ggaaaaagaa gaaatgacaa attaa                      885


<210>  4
<211>  293
<212>  PRT
<213>  Artificial sequence

<220>
<223>  alpha-hemolysin mutant E111N/K147N

<400>  4

Ala Asp Ser Asp Ile Asn Ile Lys Thr Gly Thr Thr Asp Ile Gly Ser 
1               5                   10                  15      


Asn Thr Thr Val Lys Thr Gly Asp Leu Val Thr Tyr Asp Lys Glu Asn 
            20                  25                  30          


Gly Met His Lys Lys Val Phe Tyr Ser Phe Ile Asp Asp Lys Asn His 
        35                  40                  45              


Asn Lys Lys Leu Leu Val Ile Arg Thr Lys Gly Thr Ile Ala Gly Gln 
    50                  55                  60                  


Tyr Arg Val Tyr Ser Glu Glu Gly Ala Asn Lys Ser Gly Leu Ala Trp 
65                  70                  75                  80  


Pro Ser Ala Phe Lys Val Gln Leu Gln Leu Pro Asp Asn Glu Val Ala 
                85                  90                  95      


Gln Ile Ser Asp Tyr Tyr Pro Arg Asn Ser Ile Asp Thr Lys Asn Tyr 
            100                 105                 110         


Met Ser Thr Leu Thr Tyr Gly Phe Asn Gly Asn Val Thr Gly Asp Asp 
        115                 120                 125             


Thr Gly Lys Ile Gly Gly Leu Ile Gly Ala Asn Val Ser Ile Gly His 
    130                 135                 140                 


Thr Leu Asn Tyr Val Gln Pro Asp Phe Lys Thr Ile Leu Glu Ser Pro 
145                 150                 155                 160 


Thr Asp Lys Lys Val Gly Trp Lys Val Ile Phe Asn Asn Met Val Asn 
                165                 170                 175     


Gln Asn Trp Gly Pro Tyr Asp Arg Asp Ser Trp Asn Pro Val Tyr Gly 
            180                 185                 190         


Asn Gln Leu Phe Met Lys Thr Arg Asn Gly Ser Met Lys Ala Ala Asp 
        195                 200                 205             


Asn Phe Leu Asp Pro Asn Lys Ala Ser Ser Leu Leu Ser Ser Gly Phe 
    210                 215                 220                 


Ser Pro Asp Phe Ala Thr Val Ile Thr Met Asp Arg Lys Ala Ser Lys 
225                 230                 235                 240 


Gln Gln Thr Asn Ile Asp Val Ile Tyr Glu Arg Val Arg Asp Asp Tyr 
                245                 250                 255     


Gln Leu His Trp Thr Ser Thr Asn Trp Lys Gly Thr Asn Thr Lys Asp 
            260                 265                 270         


Lys Trp Thr Asp Arg Ser Ser Glu Arg Tyr Lys Ile Asp Trp Glu Lys 
        275                 280                 285             


Glu Glu Met Thr Asn 
    290             


<210>  5
<211>  184
<212>  PRT
<213>  Mycobacterium smegmatis

<400>  5

Gly Leu Asp Asn Glu Leu Ser Leu Val Asp Gly Gln Asp Arg Thr Leu 
1               5                   10                  15      


Thr Val Gln Gln Trp Asp Thr Phe Leu Asn Gly Val Phe Pro Leu Asp 
            20                  25                  30          


Arg Asn Arg Leu Thr Arg Glu Trp Phe His Ser Gly Arg Ala Lys Tyr 
        35                  40                  45              


Ile Val Ala Gly Pro Gly Ala Asp Glu Phe Glu Gly Thr Leu Glu Leu 
    50                  55                  60                  


Gly Tyr Gln Ile Gly Phe Pro Trp Ser Leu Gly Val Gly Ile Asn Phe 
65                  70                  75                  80  


Ser Tyr Thr Thr Pro Asn Ile Leu Ile Asp Asp Gly Asp Ile Thr Ala 
                85                  90                  95      


Pro Pro Phe Gly Leu Asn Ser Val Ile Thr Pro Asn Leu Phe Pro Gly 
            100                 105                 110         


Val Ser Ile Ser Ala Asp Leu Gly Asn Gly Pro Gly Ile Gln Glu Val 
        115                 120                 125             


Ala Thr Phe Ser Val Asp Val Ser Gly Pro Ala Gly Gly Val Ala Val 
    130                 135                 140                 


Ser Asn Ala His Gly Thr Val Thr Gly Ala Ala Gly Gly Val Leu Leu 
145                 150                 155                 160 


Arg Pro Phe Ala Arg Leu Ile Ala Ser Thr Gly Asp Ser Val Thr Thr 
                165                 170                 175     


Tyr Gly Glu Pro Trp Asn Met Asn 
            180                 


<210>  6
<211>  184
<212>  PRT
<213>  Mycobacterium smegmatis

<400>  6

Gly Leu Asp Asn Glu Leu Ser Leu Val Asp Gly Gln Asp Arg Thr Leu 
1               5                   10                  15      


Thr Val Gln Gln Trp Asp Thr Phe Leu Asn Gly Val Phe Pro Leu Asp 
            20                  25                  30          


Arg Asn Arg Leu Thr Arg Glu Trp Phe His Ser Gly Arg Ala Lys Tyr 
        35                  40                  45              


Ile Val Ala Gly Pro Gly Ala Asp Glu Phe Glu Gly Thr Leu Glu Leu 
    50                  55                  60                  


Gly Tyr Gln Ile Gly Phe Pro Trp Ser Leu Gly Val Gly Ile Asn Phe 
65                  70                  75                  80  


Ser Tyr Thr Thr Pro Asn Ile Leu Ile Asp Asp Gly Asp Ile Thr Gly 
                85                  90                  95      


Pro Pro Phe Gly Leu Glu Ser Val Ile Thr Pro Asn Leu Phe Pro Gly 
            100                 105                 110         


Val Ser Ile Ser Ala Asp Leu Gly Asn Gly Pro Gly Ile Gln Glu Val 
        115                 120                 125             


Ala Thr Phe Ser Val Asp Val Ser Gly Pro Ala Gly Gly Val Ala Val 
    130                 135                 140                 


Ser Asn Ala His Gly Thr Val Thr Gly Ala Ala Gly Gly Val Leu Leu 
145                 150                 155                 160 


Arg Pro Phe Ala Arg Leu Ile Ala Ser Thr Gly Asp Ser Val Thr Thr 
                165                 170                 175     


Tyr Gly Glu Pro Trp Asn Met Asn 
            180                 


<210>  7
<211>  183
<212>  PRT
<213>  Mycobacterium smegmatis

<400>  7

Val Asp Asn Gln Leu Ser Val Val Asp Gly Gln Gly Arg Thr Leu Thr 
1               5                   10                  15      


Val Gln Gln Ala Glu Thr Phe Leu Asn Gly Val Phe Pro Leu Asp Arg 
            20                  25                  30          


Asn Arg Leu Thr Arg Glu Trp Phe His Ser Gly Arg Ala Thr Tyr His 
        35                  40                  45              


Val Ala Gly Pro Gly Ala Asp Glu Phe Glu Gly Thr Leu Glu Leu Gly 
    50                  55                  60                  


Tyr Gln Val Gly Phe Pro Trp Ser Leu Gly Val Gly Ile Asn Phe Ser 
65                  70                  75                  80  


Tyr Thr Thr Pro Asn Ile Leu Ile Asp Gly Gly Asp Ile Thr Gln Pro 
                85                  90                  95      


Pro Phe Gly Leu Asp Thr Ile Ile Thr Pro Asn Leu Phe Pro Gly Val 
            100                 105                 110         


Ser Ile Ser Ala Asp Leu Gly Asn Gly Pro Gly Ile Gln Glu Val Ala 
        115                 120                 125             


Thr Phe Ser Val Asp Val Lys Gly Ala Lys Gly Ala Val Ala Val Ser 
    130                 135                 140                 


Asn Ala His Gly Thr Val Thr Gly Ala Ala Gly Gly Val Leu Leu Arg 
145                 150                 155                 160 


Pro Phe Ala Arg Leu Ile Ala Ser Thr Gly Asp Ser Val Thr Thr Tyr 
                165                 170                 175     


Gly Glu Pro Trp Asn Met Asn 
            180             


<210>  8
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Amino acid sequence of the Hel308 motif


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = C, M or L

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa = any amino acid

<400>  8

Gln Xaa Xaa Gly Arg Ala Gly Arg 
1               5               


<210>  9
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Amino acid sequence of the extended Hel308 motif


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = C, M or L

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa = any amino acid

<400>  9

Gln Xaa Xaa Gly Arg Ala Gly Arg Pro 
1               5                   


<210>  10
<211>  760
<212>  PRT
<213>  Methanococcoides burtonii

<400>  10

Met Met Ile Arg Glu Leu Asp Ile Pro Arg Asp Ile Ile Gly Phe Tyr 
1               5                   10                  15      


Glu Asp Ser Gly Ile Lys Glu Leu Tyr Pro Pro Gln Ala Glu Ala Ile 
            20                  25                  30          


Glu Met Gly Leu Leu Glu Lys Lys Asn Leu Leu Ala Ala Ile Pro Thr 
        35                  40                  45              


Ala Ser Gly Lys Thr Leu Leu Ala Glu Leu Ala Met Ile Lys Ala Ile 
    50                  55                  60                  


Arg Glu Gly Gly Lys Ala Leu Tyr Ile Val Pro Leu Arg Ala Leu Ala 
65                  70                  75                  80  


Ser Glu Lys Phe Glu Arg Phe Lys Glu Leu Ala Pro Phe Gly Ile Lys 
                85                  90                  95      


Val Gly Ile Ser Thr Gly Asp Leu Asp Ser Arg Ala Asp Trp Leu Gly 
            100                 105                 110         


Val Asn Asp Ile Ile Val Ala Thr Ser Glu Lys Thr Asp Ser Leu Leu 
        115                 120                 125             


Arg Asn Gly Thr Ser Trp Met Asp Glu Ile Thr Thr Val Val Val Asp 
    130                 135                 140                 


Glu Ile His Leu Leu Asp Ser Lys Asn Arg Gly Pro Thr Leu Glu Val 
145                 150                 155                 160 


Thr Ile Thr Lys Leu Met Arg Leu Asn Pro Asp Val Gln Val Val Ala 
                165                 170                 175     


Leu Ser Ala Thr Val Gly Asn Ala Arg Glu Met Ala Asp Trp Leu Gly 
            180                 185                 190         


Ala Ala Leu Val Leu Ser Glu Trp Arg Pro Thr Asp Leu His Glu Gly 
        195                 200                 205             


Val Leu Phe Gly Asp Ala Ile Asn Phe Pro Gly Ser Gln Lys Lys Ile 
    210                 215                 220                 


Asp Arg Leu Glu Lys Asp Asp Ala Val Asn Leu Val Leu Asp Thr Ile 
225                 230                 235                 240 


Lys Ala Glu Gly Gln Cys Leu Val Phe Glu Ser Ser Arg Arg Asn Cys 
                245                 250                 255     


Ala Gly Phe Ala Lys Thr Ala Ser Ser Lys Val Ala Lys Ile Leu Asp 
            260                 265                 270         


Asn Asp Ile Met Ile Lys Leu Ala Gly Ile Ala Glu Glu Val Glu Ser 
        275                 280                 285             


Thr Gly Glu Thr Asp Thr Ala Ile Val Leu Ala Asn Cys Ile Arg Lys 
    290                 295                 300                 


Gly Val Ala Phe His His Ala Gly Leu Asn Ser Asn His Arg Lys Leu 
305                 310                 315                 320 


Val Glu Asn Gly Phe Arg Gln Asn Leu Ile Lys Val Ile Ser Ser Thr 
                325                 330                 335     


Pro Thr Leu Ala Ala Gly Leu Asn Leu Pro Ala Arg Arg Val Ile Ile 
            340                 345                 350         


Arg Ser Tyr Arg Arg Phe Asp Ser Asn Phe Gly Met Gln Pro Ile Pro 
        355                 360                 365             


Val Leu Glu Tyr Lys Gln Met Ala Gly Arg Ala Gly Arg Pro His Leu 
    370                 375                 380                 


Asp Pro Tyr Gly Glu Ser Val Leu Leu Ala Lys Thr Tyr Asp Glu Phe 
385                 390                 395                 400 


Ala Gln Leu Met Glu Asn Tyr Val Glu Ala Asp Ala Glu Asp Ile Trp 
                405                 410                 415     


Ser Lys Leu Gly Thr Glu Asn Ala Leu Arg Thr His Val Leu Ser Thr 
            420                 425                 430         


Ile Val Asn Gly Phe Ala Ser Thr Arg Gln Glu Leu Phe Asp Phe Phe 
        435                 440                 445             


Gly Ala Thr Phe Phe Ala Tyr Gln Gln Asp Lys Trp Met Leu Glu Glu 
    450                 455                 460                 


Val Ile Asn Asp Cys Leu Glu Phe Leu Ile Asp Lys Ala Met Val Ser 
465                 470                 475                 480 


Glu Thr Glu Asp Ile Glu Asp Ala Ser Lys Leu Phe Leu Arg Gly Thr 
                485                 490                 495     


Arg Leu Gly Ser Leu Val Ser Met Leu Tyr Ile Asp Pro Leu Ser Gly 
            500                 505                 510         


Ser Lys Ile Val Asp Gly Phe Lys Asp Ile Gly Lys Ser Thr Gly Gly 
        515                 520                 525             


Asn Met Gly Ser Leu Glu Asp Asp Lys Gly Asp Asp Ile Thr Val Thr 
    530                 535                 540                 


Asp Met Thr Leu Leu His Leu Val Cys Ser Thr Pro Asp Met Arg Gln 
545                 550                 555                 560 


Leu Tyr Leu Arg Asn Thr Asp Tyr Thr Ile Val Asn Glu Tyr Ile Val 
                565                 570                 575     


Ala His Ser Asp Glu Phe His Glu Ile Pro Asp Lys Leu Lys Glu Thr 
            580                 585                 590         


Asp Tyr Glu Trp Phe Met Gly Glu Val Lys Thr Ala Met Leu Leu Glu 
        595                 600                 605             


Glu Trp Val Thr Glu Val Ser Ala Glu Asp Ile Thr Arg His Phe Asn 
    610                 615                 620                 


Val Gly Glu Gly Asp Ile His Ala Leu Ala Asp Thr Ser Glu Trp Leu 
625                 630                 635                 640 


Met His Ala Ala Ala Lys Leu Ala Glu Leu Leu Gly Val Glu Tyr Ser 
                645                 650                 655     


Ser His Ala Tyr Ser Leu Glu Lys Arg Ile Arg Tyr Gly Ser Gly Leu 
            660                 665                 670         


Asp Leu Met Glu Leu Val Gly Ile Arg Gly Val Gly Arg Val Arg Ala 
        675                 680                 685             


Arg Lys Leu Tyr Asn Ala Gly Phe Val Ser Val Ala Lys Leu Lys Gly 
    690                 695                 700                 


Ala Asp Ile Ser Val Leu Ser Lys Leu Val Gly Pro Lys Val Ala Tyr 
705                 710                 715                 720 


Asn Ile Leu Ser Gly Ile Gly Val Arg Val Asn Asp Lys His Phe Asn 
                725                 730                 735     


Ser Ala Pro Ile Ser Ser Asn Thr Leu Asp Thr Leu Leu Asp Lys Asn 
            740                 745                 750         


Gln Lys Thr Phe Asn Asp Phe Gln 
        755                 760 


<210>  11
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Exemplary Hel308 motif

<400>  11

Gln Met Ala Gly Arg Ala Gly Arg 
1               5               


<210>  12
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Exemplary extended Hel308 motif

<400>  12

Gln Met Ala Gly Arg Ala Gly Arg Pro 
1               5                   


<210>  13
<211>  720
<212>  PRT
<213>  Pyrococcus furiosus

<400>  13

Met Arg Val Asp Glu Leu Arg Val Asp Glu Arg Ile Lys Ser Thr Leu 
1               5                   10                  15      


Lys Glu Arg Gly Ile Glu Ser Phe Tyr Pro Pro Gln Ala Glu Ala Leu 
            20                  25                  30          


Lys Ser Gly Ile Leu Glu Gly Lys Asn Ala Leu Ile Ser Ile Pro Thr 
        35                  40                  45              


Ala Ser Gly Lys Thr Leu Ile Ala Glu Ile Ala Met Val His Arg Ile 
    50                  55                  60                  


Leu Thr Gln Gly Gly Lys Ala Val Tyr Ile Val Pro Leu Lys Ala Leu 
65                  70                  75                  80  


Ala Glu Glu Lys Phe Gln Glu Phe Gln Asp Trp Glu Lys Ile Gly Leu 
                85                  90                  95      


Arg Val Ala Met Ala Thr Gly Asp Tyr Asp Ser Lys Asp Glu Trp Leu 
            100                 105                 110         


Gly Lys Tyr Asp Ile Ile Ile Ala Thr Ala Glu Lys Phe Asp Ser Leu 
        115                 120                 125             


Leu Arg His Gly Ser Ser Trp Ile Lys Asp Val Lys Ile Leu Val Ala 
    130                 135                 140                 


Asp Glu Ile His Leu Ile Gly Ser Arg Asp Arg Gly Ala Thr Leu Glu 
145                 150                 155                 160 


Val Ile Leu Ala His Met Leu Gly Lys Ala Gln Ile Ile Gly Leu Ser 
                165                 170                 175     


Ala Thr Ile Gly Asn Pro Glu Glu Leu Ala Glu Trp Leu Asn Ala Glu 
            180                 185                 190         


Leu Ile Val Ser Asp Trp Arg Pro Val Lys Leu Arg Arg Gly Val Phe 
        195                 200                 205             


Tyr Gln Gly Phe Val Thr Trp Glu Asp Gly Ser Ile Asp Arg Phe Ser 
    210                 215                 220                 


Ser Trp Glu Glu Leu Val Tyr Asp Ala Ile Arg Lys Lys Lys Gly Ala 
225                 230                 235                 240 


Leu Ile Phe Val Asn Met Arg Arg Lys Ala Glu Arg Val Ala Leu Glu 
                245                 250                 255     


Leu Ser Lys Lys Val Lys Ser Leu Leu Thr Lys Pro Glu Ile Arg Ala 
            260                 265                 270         


Leu Asn Glu Leu Ala Asp Ser Leu Glu Glu Asn Pro Thr Asn Glu Lys 
        275                 280                 285             


Leu Ala Lys Ala Ile Arg Gly Gly Val Ala Phe His His Ala Gly Leu 
    290                 295                 300                 


Gly Arg Asp Glu Arg Val Leu Val Glu Glu Asn Phe Arg Lys Gly Ile 
305                 310                 315                 320 


Ile Lys Ala Val Val Ala Thr Pro Thr Leu Ser Ala Gly Ile Asn Thr 
                325                 330                 335     


Pro Ala Phe Arg Val Ile Ile Arg Asp Ile Trp Arg Tyr Ser Asp Phe 
            340                 345                 350         


Gly Met Glu Arg Ile Pro Ile Ile Glu Val His Gln Met Leu Gly Arg 
        355                 360                 365             


Ala Gly Arg Pro Lys Tyr Asp Glu Val Gly Glu Gly Ile Ile Val Ser 
    370                 375                 380                 


Thr Ser Asp Asp Pro Arg Glu Val Met Asn His Tyr Ile Phe Gly Lys 
385                 390                 395                 400 


Pro Glu Lys Leu Phe Ser Gln Leu Ser Asn Glu Ser Asn Leu Arg Ser 
                405                 410                 415     


Gln Val Leu Ala Leu Ile Ala Thr Phe Gly Tyr Ser Thr Val Glu Glu 
            420                 425                 430         


Ile Leu Lys Phe Ile Ser Asn Thr Phe Tyr Ala Tyr Gln Arg Lys Asp 
        435                 440                 445             


Thr Tyr Ser Leu Glu Glu Lys Ile Arg Asn Ile Leu Tyr Phe Leu Leu 
    450                 455                 460                 


Glu Asn Glu Phe Ile Glu Ile Ser Leu Glu Asp Lys Ile Arg Pro Leu 
465                 470                 475                 480 


Ser Leu Gly Ile Arg Thr Ala Lys Leu Tyr Ile Asp Pro Tyr Thr Ala 
                485                 490                 495     


Lys Met Phe Lys Asp Lys Met Glu Glu Val Val Lys Asp Pro Asn Pro 
            500                 505                 510         


Ile Gly Ile Phe His Leu Ile Ser Leu Thr Pro Asp Ile Thr Pro Phe 
        515                 520                 525             


Asn Tyr Ser Lys Arg Glu Phe Glu Arg Leu Glu Glu Glu Tyr Tyr Glu 
    530                 535                 540                 


Phe Lys Asp Arg Leu Tyr Phe Asp Asp Pro Tyr Ile Ser Gly Tyr Asp 
545                 550                 555                 560 


Pro Tyr Leu Glu Arg Lys Phe Phe Arg Ala Phe Lys Thr Ala Leu Val 
                565                 570                 575     


Leu Leu Ala Trp Ile Asn Glu Val Pro Glu Gly Glu Ile Val Glu Lys 
            580                 585                 590         


Tyr Ser Val Glu Pro Gly Asp Ile Tyr Arg Ile Val Glu Thr Ala Glu 
        595                 600                 605             


Trp Leu Val Tyr Ser Leu Lys Glu Ile Ala Lys Val Leu Gly Ala Tyr 
    610                 615                 620                 


Glu Ile Val Asp Tyr Leu Glu Thr Leu Arg Val Arg Val Lys Tyr Gly 
625                 630                 635                 640 


Ile Arg Glu Glu Leu Ile Pro Leu Met Gln Leu Pro Leu Val Gly Arg 
                645                 650                 655     


Arg Arg Ala Arg Ala Leu Tyr Asn Ser Gly Phe Arg Ser Ile Glu Asp 
            660                 665                 670         


Ile Ser Gln Ala Arg Pro Glu Glu Leu Leu Lys Ile Glu Gly Ile Gly 
        675                 680                 685             


Val Lys Thr Val Glu Ala Ile Phe Lys Phe Leu Gly Lys Asn Val Lys 
    690                 695                 700                 


Ile Ser Glu Lys Pro Arg Lys Ser Thr Leu Asp Tyr Phe Leu Lys Ser 
705                 710                 715                 720 


<210>  14
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Exemplary Hel308 motif

<400>  14

Gln Met Leu Gly Arg Ala Gly Arg 
1               5               


<210>  15
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Exemplary extended Hel308 motif

<400>  15

Gln Met Leu Gly Arg Ala Gly Arg Pro 
1               5                   


<210>  16
<211>  829
<212>  PRT
<213>  Haloferax volcanii

<400>  16

Met Arg Thr Ala Asp Leu Thr Gly Leu Pro Thr Gly Ile Pro Glu Ala 
1               5                   10                  15      


Leu Arg Asp Glu Gly Ile Glu Glu Leu Tyr Pro Pro Gln Ala Glu Ala 
            20                  25                  30          


Val Glu Ala Gly Leu Thr Asp Gly Glu Ser Leu Val Ala Ala Val Pro 
        35                  40                  45              


Thr Ala Ser Gly Lys Thr Leu Ile Ala Glu Leu Ala Met Leu Ser Ser 
    50                  55                  60                  


Val Ala Arg Gly Gly Lys Ala Leu Tyr Ile Val Pro Leu Arg Ala Leu 
65                  70                  75                  80  


Ala Ser Glu Lys Lys Ala Glu Phe Glu Arg Trp Glu Glu Tyr Gly Ile 
                85                  90                  95      


Asp Val Gly Val Ser Thr Gly Asn Tyr Glu Ser Asp Gly Glu Trp Leu 
            100                 105                 110         


Ser Ser Arg Asp Ile Ile Val Ala Thr Ser Glu Lys Val Asp Ser Leu 
        115                 120                 125             


Val Arg Asn Asn Ala Ala Trp Met Asp Gln Leu Thr Cys Val Val Ala 
    130                 135                 140                 


Asp Glu Val His Leu Val Asp Asp Arg His Arg Gly Pro Thr Leu Glu 
145                 150                 155                 160 


Val Thr Leu Ala Lys Leu Arg Arg Leu Asn Thr Asn Leu Gln Val Val 
                165                 170                 175     


Ala Leu Ser Ala Thr Val Gly Asn Ala Gly Val Val Ser Asp Trp Leu 
            180                 185                 190         


Asp Ala Glu Leu Val Lys Ser Asp Trp Arg Pro Ile Asp Leu Lys Met 
        195                 200                 205             


Gly Val His Tyr Gly Asn Ala Val Ser Phe Ala Asp Gly Ser Gln Arg 
    210                 215                 220                 


Glu Val Pro Val Gly Arg Gly Glu Arg Gln Thr Pro Ala Leu Val Ala 
225                 230                 235                 240 


Asp Ala Leu Glu Gly Asp Gly Glu Gly Asp Gln Gly Ser Ser Leu Val 
                245                 250                 255     


Phe Val Asn Ser Arg Arg Asn Ala Glu Ser Ala Ala Arg Arg Met Ala 
            260                 265                 270         


Asp Val Thr Glu Arg Tyr Val Thr Gly Asp Glu Arg Ser Asp Leu Ala 
        275                 280                 285             


Glu Leu Ala Ala Glu Ile Arg Asp Val Ser Asp Thr Glu Thr Ser Asp 
    290                 295                 300                 


Asp Leu Ala Asn Ala Val Ala Lys Gly Ala Ala Phe His His Ala Gly 
305                 310                 315                 320 


Leu Ala Ala Glu His Arg Thr Leu Val Glu Asp Ala Phe Arg Asp Arg 
                325                 330                 335     


Leu Ile Lys Cys Ile Cys Ala Thr Pro Thr Leu Ala Ala Gly Val Asn 
            340                 345                 350         


Thr Pro Ser Arg Arg Val Val Val Arg Asp Trp Gln Arg Tyr Asp Gly 
        355                 360                 365             


Asp Tyr Gly Gly Met Lys Pro Leu Asp Val Leu Glu Val His Gln Met 
    370                 375                 380                 


Met Gly Arg Ala Gly Arg Pro Gly Leu Asp Pro Tyr Gly Glu Ala Val 
385                 390                 395                 400 


Leu Leu Ala Lys Asp Ala Asp Ala Arg Asp Glu Leu Phe Glu Arg Tyr 
                405                 410                 415     


Ile Trp Ala Asp Ala Glu Asp Val Arg Ser Lys Leu Ala Ala Glu Pro 
            420                 425                 430         


Ala Leu Arg Thr His Leu Leu Ala Thr Val Ala Ser Gly Phe Ala His 
        435                 440                 445             


Thr Arg Glu Gly Leu Leu Glu Phe Leu Asp Gln Thr Leu Tyr Ala Thr 
    450                 455                 460                 


Gln Thr Asp Asp Pro Glu Arg Leu Gly Gln Val Thr Asp Arg Val Leu 
465                 470                 475                 480 


Asp Tyr Leu Glu Val Asn Gly Phe Val Glu Phe Glu Gly Glu Thr Ile 
                485                 490                 495     


Gln Ala Thr Pro Val Gly His Thr Val Ser Arg Leu Tyr Leu Asp Pro 
            500                 505                 510         


Met Ser Ala Ala Glu Ile Ile Asp Gly Leu Glu Trp Ala Ala Asp His 
        515                 520                 525             


Arg Thr Glu Lys Leu Arg Ala Leu Ala Gly Glu Thr Pro Glu Lys Pro 
    530                 535                 540                 


Thr Arg Asp Arg Ser Glu Ser Asp Glu Ser Gly Gly Phe Gln Arg Ala 
545                 550                 555                 560 


Ser Glu Met Val Ala Asp Asp Gly Asp Gly Gly Gly Gly Glu Asp Gly 
                565                 570                 575     


Val Gly Ala Asn Gly Asp Gly Asp Ser Asp Asp Ala Asp Gly Val Glu 
            580                 585                 590         


Thr Asp Arg Thr Tyr Pro Thr Pro Leu Gly Leu Tyr His Leu Val Cys 
        595                 600                 605             


Arg Thr Pro Asp Met Tyr Gln Leu Tyr Leu Lys Ser Gly Asp Arg Glu 
    610                 615                 620                 


Thr Tyr Thr Glu Leu Cys Tyr Glu Arg Glu Pro Glu Phe Leu Gly Arg 
625                 630                 635                 640 


Val Pro Ser Glu Tyr Glu Asp Val Ala Phe Glu Asp Trp Leu Ser Ala 
                645                 650                 655     


Leu Lys Thr Ala Lys Leu Leu Glu Asp Trp Val Gly Glu Val Asp Glu 
            660                 665                 670         


Asp Arg Ile Thr Glu Arg Tyr Gly Val Gly Pro Gly Asp Ile Arg Gly 
        675                 680                 685             


Lys Val Glu Thr Ser Glu Trp Leu Leu Gly Ala Ala Glu Arg Leu Ala 
    690                 695                 700                 


Thr Glu Leu Asp Leu Asp Ser Val Tyr Ala Val Arg Glu Ala Lys Lys 
705                 710                 715                 720 


Arg Val Glu Tyr Gly Val Arg Glu Glu Leu Leu Asp Leu Ala Gly Val 
                725                 730                 735     


Arg Gly Val Gly Arg Lys Arg Ala Arg Arg Leu Phe Glu Ala Gly Val 
            740                 745                 750         


Glu Thr Arg Ala Asp Leu Arg Glu Ala Asp Lys Pro Arg Val Leu Ala 
        755                 760                 765             


Ala Leu Arg Gly Arg Arg Lys Thr Ala Glu Asn Ile Leu Glu Ala Ala 
    770                 775                 780                 


Gly Arg Lys Asp Pro Ser Met Asp Ala Val Asp Glu Asp Asp Ala Pro 
785                 790                 795                 800 


Asp Asp Ala Val Pro Asp Asp Ala Gly Phe Glu Thr Ala Lys Glu Arg 
                805                 810                 815     


Ala Asp Gln Gln Ala Ser Leu Gly Asp Phe Glu Gly Ser 
            820                 825                 


<210>  17
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Exemplary Hel308 motif

<400>  17

Gln Met Met Gly Arg Ala Gly Arg 
1               5               


<210>  18
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Exemplary extended Hel308 motif

<400>  18

Gln Met Met Gly Arg Ala Gly Arg Pro 
1               5                   


<210>  19
<211>  824
<212>  PRT
<213>  Halorubrum lacusprofundi

<400>  19

Met Gln Pro Ser Ser Leu Ser Gly Leu Pro Ala Gly Val Gly Glu Ala 
1               5                   10                  15      


Leu Glu Ala Glu Gly Val Ala Glu Leu Tyr Pro Pro Gln Glu Ala Ala 
            20                  25                  30          


Val Glu Ala Gly Val Ala Asp Gly Glu Ser Leu Val Ala Ala Val Pro 
        35                  40                  45              


Thr Ala Ser Gly Lys Thr Leu Ile Ala Glu Leu Ala Met Leu Ser Ser 
    50                  55                  60                  


Ile Glu Arg Gly Gly Lys Ala Leu Tyr Ile Val Pro Leu Arg Ala Leu 
65                  70                  75                  80  


Ala Ser Glu Lys Lys Thr Glu Phe Glu Arg Trp Glu Glu Phe Gly Val 
                85                  90                  95      


Thr Val Gly Val Ser Thr Gly Asn Tyr Glu Ser Asp Gly Glu Trp Leu 
            100                 105                 110         


Ala Thr Arg Asp Ile Ile Val Ala Thr Ser Glu Lys Val Asp Ser Leu 
        115                 120                 125             


Ile Arg Asn Gly Ala Pro Trp Ile Asp Asp Leu Thr Cys Val Val Ser 
    130                 135                 140                 


Asp Glu Val His Leu Val Asp Asp Pro Asn Arg Gly Pro Thr Leu Glu 
145                 150                 155                 160 


Val Thr Leu Ala Lys Leu Arg Lys Val Asn Pro Gly Leu Gln Thr Val 
                165                 170                 175     


Ala Leu Ser Ala Thr Val Gly Asn Ala Asp Val Ile Ala Glu Trp Leu 
            180                 185                 190         


Asp Ala Glu Leu Val Glu Ser Asp Trp Arg Pro Ile Asp Leu Arg Met 
        195                 200                 205             


Gly Val His Phe Gly Asn Ala Ile Asp Phe Ala Asp Gly Ser Lys Arg 
    210                 215                 220                 


Glu Val Pro Val Glu Arg Gly Glu Asp Gln Thr Ala Arg Leu Val Ala 
225                 230                 235                 240 


Asp Ala Leu Asp Thr Glu Glu Asp Gly Gln Gly Gly Ser Ser Leu Val 
                245                 250                 255     


Phe Val Asn Ser Arg Arg Asn Ala Glu Ser Ser Ala Arg Lys Leu Thr 
            260                 265                 270         


Asp Val Thr Gly Pro Arg Leu Thr Asp Asp Glu Arg Asp Gln Leu Arg 
        275                 280                 285             


Glu Leu Ala Asp Glu Ile Arg Ser Gly Ser Asp Thr Asp Thr Ala Ser 
    290                 295                 300                 


Asp Leu Ala Asp Ala Val Glu Gln Gly Ser Ala Phe His His Ala Gly 
305                 310                 315                 320 


Leu Arg Ser Glu Asp Arg Ala Arg Val Glu Asp Ala Phe Arg Asp Arg 
                325                 330                 335     


Leu Ile Lys Cys Ile Ser Ala Thr Pro Thr Leu Ala Ala Gly Val Asn 
            340                 345                 350         


Thr Pro Ala Arg Arg Val Ile Val Arg Asp Trp Arg Arg Tyr Asp Gly 
        355                 360                 365             


Glu Phe Gly Gly Met Lys Pro Leu Asp Val Leu Glu Val His Gln Met 
    370                 375                 380                 


Cys Gly Arg Ala Gly Arg Pro Gly Leu Asp Pro Tyr Gly Glu Ala Val 
385                 390                 395                 400 


Leu Leu Ala Asn Asp Ala Asp Thr Lys Glu Glu Leu Phe Glu Arg Tyr 
                405                 410                 415     


Leu Trp Ala Asp Pro Glu Pro Val Arg Ser Lys Leu Ala Ala Glu Pro 
            420                 425                 430         


Ala Leu Arg Thr His Val Leu Ala Thr Val Ala Ser Gly Phe Ala Ser 
        435                 440                 445             


Thr Arg Asp Gly Leu Leu Ser Phe Leu Asp Asn Thr Leu Tyr Ala Thr 
    450                 455                 460                 


Gln Thr Asp Asp Glu Gly Arg Leu Ala Ala Val Thr Asp Thr Val Leu 
465                 470                 475                 480 


Asp Tyr Leu Ala Val Asn Asp Phe Ile Glu Arg Asp Arg Asp Gly Gly 
                485                 490                 495     


Ser Glu Ser Leu Thr Ala Thr Gly Ile Gly His Thr Val Ser Arg Leu 
            500                 505                 510         


Tyr Leu Asp Pro Met Ser Ala Ala Glu Met Ile Asp Gly Leu Arg Ser 
        515                 520                 525             


Val Ala Arg Asp Ala Ala Asp Thr Gly Ala Ser Ala Glu Ala Asp Asn 
    530                 535                 540                 


Gly Glu Phe Val Arg Thr Gly Asp Ala Asp Asp Ala Ser Gly Gly Asp 
545                 550                 555                 560 


Glu Pro Gly Phe Gly Thr Tyr Thr Arg Ala Gly Asp Asp Glu Ser Gly 
                565                 570                 575     


Glu Arg Glu Thr Glu Asn Glu Glu Thr Asp Glu Glu Glu Thr Glu Ala 
            580                 585                 590         


Ser Glu Val Thr Pro Leu Gly Leu Tyr His Leu Ile Ser Arg Thr Pro 
        595                 600                 605             


Asp Met Tyr Glu Leu Tyr Leu Lys Ser Gly Asp Arg Glu Thr Tyr Thr 
    610                 615                 620                 


Glu Leu Cys Tyr Glu Arg Glu Thr Glu Phe Leu Gly Asp Val Pro Ser 
625                 630                 635                 640 


Glu Tyr Glu Asp Val Arg Phe Glu Asp Trp Leu Ala Ser Leu Lys Thr 
                645                 650                 655     


Ala Arg Leu Leu Glu Asp Trp Val Asn Glu Val Asp Glu Asp Arg Ile 
            660                 665                 670         


Thr Glu Arg Tyr Gly Val Gly Pro Gly Asp Ile Arg Gly Lys Val Asp 
        675                 680                 685             


Thr Ala Glu Trp Leu Leu Arg Ala Ala Glu Thr Leu Ala Arg Asp Val 
    690                 695                 700                 


Glu Gly Val Asp Gly Asp Val Val Val Ala Val Arg Glu Ala Arg Lys 
705                 710                 715                 720 


Arg Ile Glu Tyr Gly Val Arg Glu Glu Leu Leu Asp Leu Ala Gly Val 
                725                 730                 735     


Arg Asn Val Gly Arg Lys Arg Ala Arg Arg Leu Phe Glu Ala Gly Ile 
            740                 745                 750         


Glu Thr Arg Ala Asp Leu Arg Glu Ala Asp Lys Ala Val Val Leu Gly 
        755                 760                 765             


Ala Leu Arg Gly Arg Glu Arg Thr Ala Glu Arg Ile Leu Glu His Ala 
    770                 775                 780                 


Gly Arg Glu Asp Pro Ser Met Asp Asp Val Arg Pro Asp Lys Ser Ala 
785                 790                 795                 800 


Ser Ala Ala Ala Thr Ala Gly Ser Ala Ser Asp Glu Asp Gly Glu Gly 
                805                 810                 815     


Gln Ala Ser Leu Gly Asp Phe Arg 
            820                 


<210>  20
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Exemplary Hel308 motif

<400>  20

Gln Met Cys Gly Arg Ala Gly Arg 
1               5               


<210>  21
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Exemplary extended Hel308 motif

<400>  21

Gln Met Cys Gly Arg Ala Gly Arg Pro 
1               5                   


<210>  22
<211>  707
<212>  PRT
<213>  Cenarchaeum symbiosum

<400>  22

Met Arg Ile Ser Glu Leu Asp Ile Pro Arg Pro Ala Ile Glu Phe Leu 
1               5                   10                  15      


Glu Gly Glu Gly Tyr Lys Lys Leu Tyr Pro Pro Gln Ala Ala Ala Ala 
            20                  25                  30          


Lys Ala Gly Leu Thr Asp Gly Lys Ser Val Leu Val Ser Ala Pro Thr 
        35                  40                  45              


Ala Ser Gly Lys Thr Leu Ile Ala Ala Ile Ala Met Ile Ser His Leu 
    50                  55                  60                  


Ser Arg Asn Arg Gly Lys Ala Val Tyr Leu Ser Pro Leu Arg Ala Leu 
65                  70                  75                  80  


Ala Ala Glu Lys Phe Ala Glu Phe Gly Lys Ile Gly Gly Ile Pro Leu 
                85                  90                  95      


Gly Arg Pro Val Arg Val Gly Val Ser Thr Gly Asp Phe Glu Lys Ala 
            100                 105                 110         


Gly Arg Ser Leu Gly Asn Asn Asp Ile Leu Val Leu Thr Asn Glu Arg 
        115                 120                 125             


Met Asp Ser Leu Ile Arg Arg Arg Pro Asp Trp Met Asp Glu Val Gly 
    130                 135                 140                 


Leu Val Ile Ala Asp Glu Ile His Leu Ile Gly Asp Arg Ser Arg Gly 
145                 150                 155                 160 


Pro Thr Leu Glu Met Val Leu Thr Lys Leu Arg Gly Leu Arg Ser Ser 
                165                 170                 175     


Pro Gln Val Val Ala Leu Ser Ala Thr Ile Ser Asn Ala Asp Glu Ile 
            180                 185                 190         


Ala Gly Trp Leu Asp Cys Thr Leu Val His Ser Thr Trp Arg Pro Val 
        195                 200                 205             


Pro Leu Ser Glu Gly Val Tyr Gln Asp Gly Glu Val Ala Met Gly Asp 
    210                 215                 220                 


Gly Ser Arg His Glu Val Ala Ala Thr Gly Gly Gly Pro Ala Val Asp 
225                 230                 235                 240 


Leu Ala Ala Glu Ser Val Ala Glu Gly Gly Gln Ser Leu Ile Phe Ala 
                245                 250                 255     


Asp Thr Arg Ala Arg Ser Ala Ser Leu Ala Ala Lys Ala Ser Ala Val 
            260                 265                 270         


Ile Pro Glu Ala Lys Gly Ala Asp Ala Ala Lys Leu Ala Ala Ala Ala 
        275                 280                 285             


Lys Lys Ile Ile Ser Ser Gly Gly Glu Thr Lys Leu Ala Lys Thr Leu 
    290                 295                 300                 


Ala Glu Leu Val Glu Lys Gly Ala Ala Phe His His Ala Gly Leu Asn 
305                 310                 315                 320 


Gln Asp Cys Arg Ser Val Val Glu Glu Glu Phe Arg Ser Gly Arg Ile 
                325                 330                 335     


Arg Leu Leu Ala Ser Thr Pro Thr Leu Ala Ala Gly Val Asn Leu Pro 
            340                 345                 350         


Ala Arg Arg Val Val Ile Ser Ser Val Met Arg Tyr Asn Ser Ser Ser 
        355                 360                 365             


Gly Met Ser Glu Pro Ile Ser Ile Leu Glu Tyr Lys Gln Leu Cys Gly 
    370                 375                 380                 


Arg Ala Gly Arg Pro Gln Tyr Asp Lys Ser Gly Glu Ala Ile Val Val 
385                 390                 395                 400 


Gly Gly Val Asn Ala Asp Glu Ile Phe Asp Arg Tyr Ile Gly Gly Glu 
                405                 410                 415     


Pro Glu Pro Ile Arg Ser Ala Met Val Asp Asp Arg Ala Leu Arg Ile 
            420                 425                 430         


His Val Leu Ser Leu Val Thr Thr Ser Pro Gly Ile Lys Glu Asp Asp 
        435                 440                 445             


Val Thr Glu Phe Phe Leu Gly Thr Leu Gly Gly Gln Gln Ser Gly Glu 
    450                 455                 460                 


Ser Thr Val Lys Phe Ser Val Ala Val Ala Leu Arg Phe Leu Gln Glu 
465                 470                 475                 480 


Glu Gly Met Leu Gly Arg Arg Gly Gly Arg Leu Ala Ala Thr Lys Met 
                485                 490                 495     


Gly Arg Leu Val Ser Arg Leu Tyr Met Asp Pro Met Thr Ala Val Thr 
            500                 505                 510         


Leu Arg Asp Ala Val Gly Glu Ala Ser Pro Gly Arg Met His Thr Leu 
        515                 520                 525             


Gly Phe Leu His Leu Val Ser Glu Cys Ser Glu Phe Met Pro Arg Phe 
    530                 535                 540                 


Ala Leu Arg Gln Lys Asp His Glu Val Ala Glu Met Met Leu Glu Ala 
545                 550                 555                 560 


Gly Arg Gly Glu Leu Leu Arg Pro Val Tyr Ser Tyr Glu Cys Gly Arg 
                565                 570                 575     


Gly Leu Leu Ala Leu His Arg Trp Ile Gly Glu Ser Pro Glu Ala Lys 
            580                 585                 590         


Leu Ala Glu Asp Leu Lys Phe Glu Ser Gly Asp Val His Arg Met Val 
        595                 600                 605             


Glu Ser Ser Gly Trp Leu Leu Arg Cys Ile Trp Glu Ile Ser Lys His 
    610                 615                 620                 


Gln Glu Arg Pro Asp Leu Leu Gly Glu Leu Asp Val Leu Arg Ser Arg 
625                 630                 635                 640 


Val Ala Tyr Gly Ile Lys Ala Glu Leu Val Pro Leu Val Ser Ile Lys 
                645                 650                 655     


Gly Ile Gly Arg Val Arg Ser Arg Arg Leu Phe Arg Gly Gly Ile Lys 
            660                 665                 670         


Gly Pro Gly Asp Leu Ala Ala Val Pro Val Glu Arg Leu Ser Arg Val 
        675                 680                 685             


Glu Gly Ile Gly Ala Thr Leu Ala Asn Asn Ile Lys Ser Gln Leu Arg 
    690                 695                 700                 


Lys Gly Gly 
705         


<210>  23
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Exemplary Hel308 motif

<400>  23

Gln Leu Cys Gly Arg Ala Gly Arg 
1               5               


<210>  24
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Exemplary extended Hel308 motif

<400>  24

Gln Leu Cys Gly Arg Ala Gly Arg Pro 
1               5                   


<210>  25
<211>  715
<212>  PRT
<213>  Sulfolobus solfataricus

<400>  25

Met Ser Leu Glu Leu Glu Trp Met Pro Ile Glu Asp Leu Lys Leu Pro 
1               5                   10                  15      


Ser Asn Val Ile Glu Ile Ile Lys Lys Arg Gly Ile Lys Lys Leu Asn 
            20                  25                  30          


Pro Pro Gln Thr Glu Ala Val Lys Lys Gly Leu Leu Glu Gly Asn Arg 
        35                  40                  45              


Leu Leu Leu Thr Ser Pro Thr Gly Ser Gly Lys Thr Leu Ile Ala Glu 
    50                  55                  60                  


Met Gly Ile Ile Ser Phe Leu Leu Lys Asn Gly Gly Lys Ala Ile Tyr 
65                  70                  75                  80  


Val Thr Pro Leu Arg Ala Leu Thr Asn Glu Lys Tyr Leu Thr Phe Lys 
                85                  90                  95      


Asp Trp Glu Leu Ile Gly Phe Lys Val Ala Met Thr Ser Gly Asp Tyr 
            100                 105                 110         


Asp Thr Asp Asp Ala Trp Leu Lys Asn Tyr Asp Ile Ile Ile Thr Thr 
        115                 120                 125             


Tyr Glu Lys Leu Asp Ser Leu Trp Arg His Arg Pro Glu Trp Leu Asn 
    130                 135                 140                 


Glu Val Asn Tyr Phe Val Leu Asp Glu Leu His Tyr Leu Asn Asp Pro 
145                 150                 155                 160 


Glu Arg Gly Pro Val Val Glu Ser Val Thr Ile Arg Ala Lys Arg Arg 
                165                 170                 175     


Asn Leu Leu Ala Leu Ser Ala Thr Ile Ser Asn Tyr Lys Gln Ile Ala 
            180                 185                 190         


Lys Trp Leu Gly Ala Glu Pro Val Ala Thr Asn Trp Arg Pro Val Pro 
        195                 200                 205             


Leu Ile Glu Gly Val Ile Tyr Pro Glu Arg Lys Lys Lys Glu Tyr Asn 
    210                 215                 220                 


Val Ile Phe Lys Asp Asn Thr Thr Lys Lys Val His Gly Asp Asp Ala 
225                 230                 235                 240 


Ile Ile Ala Tyr Thr Leu Asp Ser Leu Ser Lys Asn Gly Gln Val Leu 
                245                 250                 255     


Val Phe Arg Asn Ser Arg Lys Met Ala Glu Ser Thr Ala Leu Lys Ile 
            260                 265                 270         


Ala Asn Tyr Met Asn Phe Val Ser Leu Asp Glu Asn Ala Leu Ser Glu 
        275                 280                 285             


Ile Leu Lys Gln Leu Asp Asp Ile Glu Glu Gly Gly Ser Asp Glu Lys 
    290                 295                 300                 


Glu Leu Leu Lys Ser Leu Ile Ser Lys Gly Val Ala Tyr His His Ala 
305                 310                 315                 320 


Gly Leu Ser Lys Ala Leu Arg Asp Leu Ile Glu Glu Gly Phe Arg Gln 
                325                 330                 335     


Arg Lys Ile Lys Val Ile Val Ala Thr Pro Thr Leu Ala Ala Gly Val 
            340                 345                 350         


Asn Leu Pro Ala Arg Thr Val Ile Ile Gly Asp Ile Tyr Arg Phe Asn 
        355                 360                 365             


Lys Lys Ile Ala Gly Tyr Tyr Asp Glu Ile Pro Ile Met Glu Tyr Lys 
    370                 375                 380                 


Gln Met Ser Gly Arg Ala Gly Arg Pro Gly Phe Asp Gln Ile Gly Glu 
385                 390                 395                 400 


Ser Ile Val Val Val Arg Asp Lys Glu Asp Val Asp Arg Val Phe Lys 
                405                 410                 415     


Lys Tyr Val Leu Ser Asp Val Glu Pro Ile Glu Ser Lys Leu Gly Ser 
            420                 425                 430         


Glu Arg Ala Phe Tyr Thr Phe Leu Leu Gly Ile Leu Ser Ala Glu Gly 
        435                 440                 445             


Asn Leu Ser Glu Lys Gln Leu Glu Asn Phe Ala Tyr Glu Ser Leu Leu 
    450                 455                 460                 


Ala Lys Gln Leu Val Asp Val Tyr Phe Asp Arg Ala Ile Arg Trp Leu 
465                 470                 475                 480 


Leu Glu His Ser Phe Ile Lys Glu Glu Gly Asn Thr Phe Ala Leu Thr 
                485                 490                 495     


Asn Phe Gly Lys Arg Val Ala Asp Leu Tyr Ile Asn Pro Phe Thr Ala 
            500                 505                 510         


Asp Ile Ile Arg Lys Gly Leu Glu Gly His Lys Ala Ser Cys Glu Leu 
        515                 520                 525             


Ala Tyr Leu His Leu Leu Ala Phe Thr Pro Asp Gly Pro Leu Val Ser 
    530                 535                 540                 


Val Gly Arg Asn Glu Glu Glu Glu Leu Ile Glu Leu Leu Glu Asp Leu 
545                 550                 555                 560 


Asp Cys Glu Leu Leu Ile Glu Glu Pro Tyr Glu Glu Asp Glu Tyr Ser 
                565                 570                 575     


Leu Tyr Ile Asn Ala Leu Lys Val Ala Leu Ile Met Lys Asp Trp Met 
            580                 585                 590         


Asp Glu Val Asp Glu Asp Thr Ile Leu Ser Lys Tyr Asn Ile Gly Ser 
        595                 600                 605             


Gly Asp Leu Arg Asn Met Val Glu Thr Met Asp Trp Leu Thr Tyr Ser 
    610                 615                 620                 


Ala Tyr His Leu Ser Arg Glu Leu Lys Leu Asn Glu His Ala Asp Lys 
625                 630                 635                 640 


Leu Arg Ile Leu Asn Leu Arg Val Arg Asp Gly Ile Lys Glu Glu Leu 
                645                 650                 655     


Leu Glu Leu Val Gln Ile Ser Gly Val Gly Arg Lys Arg Ala Arg Leu 
            660                 665                 670         


Leu Tyr Asn Asn Gly Ile Lys Glu Leu Gly Asp Val Val Met Asn Pro 
        675                 680                 685             


Asp Lys Val Lys Asn Leu Leu Gly Gln Lys Leu Gly Glu Lys Val Val 
    690                 695                 700                 


Gln Glu Ala Ala Arg Leu Leu Asn Arg Phe His 
705                 710                 715 


<210>  26
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Exemplary Hel308 motif

<400>  26

Gln Met Ser Gly Arg Ala Gly Arg 
1               5               


<210>  27
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Exemplary extended Hel308 motif

<400>  27

Gln Met Ser Gly Arg Ala Gly Arg Pro 
1               5                   


<210>  28
<211>  685
<212>  PRT
<213>  Methanogenium frigidum

<400>  28

Met Asp Leu Ser Leu Pro Lys Ala Phe Ile Gln Tyr Tyr Lys Asp Lys 
1               5                   10                  15      


Gly Ile Glu Ser Leu Tyr Pro Pro Gln Ser Glu Cys Ile Glu Asn Gly 
            20                  25                  30          


Leu Leu Asp Gly Ala Asp Leu Leu Val Ala Ile Pro Thr Ala Ser Gly 
        35                  40                  45              


Lys Thr Leu Ile Ala Glu Met Ala Met His Ala Ala Ile Ala Arg Gly 
    50                  55                  60                  


Gly Met Cys Leu Tyr Ile Val Pro Leu Lys Ala Leu Ala Thr Glu Lys 
65                  70                  75                  80  


Ala Gln Glu Phe Lys Gly Lys Gly Ala Glu Ile Gly Val Ala Thr Gly 
                85                  90                  95      


Asp Tyr Asp Gln Lys Glu Lys Arg Leu Gly Ser Asn Asp Ile Val Ile 
            100                 105                 110         


Ala Thr Ser Glu Lys Val Asp Ser Leu Leu Arg Asn Gly Val Pro Trp 
        115                 120                 125             


Leu Ser Gln Val Thr Cys Leu Val Val Asp Glu Val His Leu Ile Asp 
    130                 135                 140                 


Asp Glu Ser Arg Gly Pro Thr Leu Glu Met Val Ile Thr Lys Leu Arg 
145                 150                 155                 160 


His Ala Ser Pro Asp Met Gln Val Ile Gly Leu Ser Ala Thr Ile Gly 
                165                 170                 175     


Asn Pro Lys Glu Leu Ala Gly Trp Leu Gly Ala Asp Leu Ile Thr Ser 
            180                 185                 190         


Asp Trp Arg Pro Val Asp Leu Arg Glu Gly Ile Cys Tyr His Asn Thr 
        195                 200                 205             


Ile Tyr Phe Asp Asn Glu Asp Lys Glu Ile Pro Ala Pro Ala Lys Thr 
    210                 215                 220                 


Glu Asp Ile Asn Leu Leu Leu Asp Cys Val Ala Asp Gly Gly Gln Cys 
225                 230                 235                 240 


Leu Val Phe Val Ser Ser Arg Arg Asn Ala Glu Gly Tyr Ala Lys Arg 
                245                 250                 255     


Ala Ala Thr Ala Leu Lys Cys Ser His Ala Ala Leu Asp Ser Ile Ala 
            260                 265                 270         


Glu Lys Leu Glu Ala Ala Ala Glu Thr Asp Met Gly Arg Val Leu Ala 
        275                 280                 285             


Thr Cys Val Lys Lys Gly Ala Ala Phe His His Ala Gly Met Asn Arg 
    290                 295                 300                 


Met Gln Arg Thr Leu Val Glu Gly Gly Phe Arg Asp Gly Phe Ile Lys 
305                 310                 315                 320 


Ser Ile Ser Ser Thr Pro Thr Leu Ala Ala Gly Leu Asn Leu Pro Ala 
                325                 330                 335     


Arg Arg Val Ile Ile Arg Asp Tyr Leu Arg Tyr Ser Gly Gly Glu Gly 
            340                 345                 350         


Met Arg Pro Ile Pro Val Arg Glu Tyr Arg Gln Met Ala Gly Arg Ala 
        355                 360                 365             


Gly Arg Pro His Leu Asp Pro Tyr Gly Glu Ala Ile Leu Ile Ala Lys 
    370                 375                 380                 


Thr Glu Tyr Ala Val Asn Asp Leu His Glu Glu Tyr Val Glu Ala Pro 
385                 390                 395                 400 


Asp Glu Asp Val Thr Ser Arg Cys Gly Glu Lys Gly Val Leu Thr Ala 
                405                 410                 415     


His Ile Leu Ser Leu Ile Ala Thr Gly Tyr Ala Arg Ser Tyr Asp Glu 
            420                 425                 430         


Leu Met Ala Phe Leu Glu Lys Thr Leu Tyr Ala Tyr Gln His Thr Gly 
        435                 440                 445             


Lys Lys Ala Leu Thr Arg Thr Leu Asp Asp Ala Leu Gly Phe Leu Thr 
    450                 455                 460                 


Glu Ala Glu Met Val Thr Asp Leu Ser Gly Met Leu His Ala Thr Glu 
465                 470                 475                 480 


Tyr Gly Asp Leu Thr Ser Arg Leu Tyr Ile Asp Pro His Ser Ala Glu 
                485                 490                 495     


Ile Ile Thr Thr Ala Leu Arg Glu Glu Gly Glu Leu Thr Asp Leu Ala 
            500                 505                 510         


Leu Leu Gln Leu Leu Cys Met Thr Pro Asp Met Phe Thr Leu Tyr Val 
        515                 520                 525             


Lys Lys Asn Asp Leu Gly Thr Leu Glu Lys Phe Phe Phe Glu His Glu 
    530                 535                 540                 


Glu Glu Phe Arg Thr Glu Phe Ser Tyr Asp Glu Met Glu Asp Phe Phe 
545                 550                 555                 560 


Arg Ser Leu Lys Thr Ala Met Leu Leu Ser Asp Trp Thr Asp Glu Ile 
                565                 570                 575     


Gly Asp Asp Thr Ile Cys Thr Arg Phe Gly Val Gly Pro Gly Asp Ile 
            580                 585                 590         


Phe Asn Ala Val Gln Gly Ile Ser Trp Leu Leu His Ala Ser Gly Arg 
        595                 600                 605             


Leu Ala Arg Leu Val Ala Pro Glu His Arg Asp Ala Val Glu Glu Thr 
    610                 615                 620                 


Thr Leu Arg Val Arg His Gly Ile Arg Arg Glu Leu Ile Pro Leu Val 
625                 630                 635                 640 


Arg Val Lys Gly Ile Gly Arg Val Arg Ala Arg Arg Leu Phe Asn Asn 
                645                 650                 655     


Gly Ile Thr Gly Pro Glu Leu Leu Ala Ala Ala Asp Pro Ser Val Val 
            660                 665                 670         


Gly His Ile Val Gly Gly Lys Thr Ala Glu Ser Ile Ile 
        675                 680                 685 


<210>  29
<211>  775
<212>  PRT
<213>  Methanothermococcus okinawensis

<400>  29

Met Leu Met Leu Met Glu Val Leu Lys Glu Asn Gly Ile Ala Glu Leu 
1               5                   10                  15      


Arg Pro Pro Gln Lys Lys Val Val Glu Gly Gly Leu Leu Asn Lys Asn 
            20                  25                  30          


Lys Asn Phe Leu Ile Cys Ile Pro Thr Ala Ser Gly Lys Thr Leu Ile 
        35                  40                  45              


Gly Glu Met Ala Phe Ile Asn His Leu Leu Asp Asn Asn Lys Thr Pro 
    50                  55                  60                  


Thr Asn Lys Lys Gly Leu Phe Ile Val Pro Leu Lys Ala Leu Ala Asn 
65                  70                  75                  80  


Glu Lys Tyr Glu Glu Phe Lys Gly Lys Tyr Glu Lys Tyr Gly Leu Lys 
                85                  90                  95      


Ile Ala Leu Ser Ile Gly Asp Phe Asp Glu Lys Glu Asp Leu Lys Gly 
            100                 105                 110         


Tyr Asp Leu Ile Ile Thr Thr Ala Glu Lys Leu Asp Ser Leu Ile Arg 
        115                 120                 125             


His Lys Val Glu Trp Ile Lys Asp Ile Ser Val Val Val Ile Asp Glu 
    130                 135                 140                 


Ile His Leu Ile Gly Asp Glu Ser Arg Gly Gly Thr Leu Glu Val Leu 
145                 150                 155                 160 


Leu Thr Lys Leu Lys Thr Lys Lys Thr Ile Gln Ile Ile Gly Leu Ser 
                165                 170                 175     


Ala Thr Ile Gly Asn Pro Glu Glu Leu Ala Lys Trp Leu Asn Ala Glu 
            180                 185                 190         


Leu Ile Val Asp Glu Trp Arg Pro Val Lys Leu Lys Lys Gly Ile Gly 
        195                 200                 205             


Tyr Gly Asn Lys Ile Met Phe Ile Asp Asp Asn Gly Asn Thr Ile Asn 
    210                 215                 220                 


Glu Val Ile Val Asp Glu Ile Ser Lys Asn Asn Met Phe Asn Leu Val 
225                 230                 235                 240 


Val Asp Ser Ile Leu Lys Asp Gly Ser Cys Ile Ile Phe Cys Asn Ser 
                245                 250                 255     


Lys Arg Gly Ala Val Gly Glu Ala Lys Lys Leu Asn Leu Lys Lys Tyr 
            260                 265                 270         


Leu Ser Pro Asp Glu Ile Ser Glu Leu Arg His Leu Lys Glu Glu Val 
        275                 280                 285             


Leu Ser Val Leu Asp Asn Pro Thr Lys Thr Cys Lys Asp Leu Ala Glu 
    290                 295                 300                 


Cys Ile Glu Lys Gly Val Ala Phe His His Ala Gly Leu Thr Tyr Glu 
305                 310                 315                 320 


Gln Arg Lys Ile Val Glu Glu Gly Phe Arg Lys Lys Leu Ile Lys Ala 
                325                 330                 335     


Ile Cys Cys Thr Pro Thr Leu Ser Ala Gly Ile Asn Met Pro Cys Arg 
            340                 345                 350         


Arg Ala Ile Ile Arg Asp Leu Lys Arg Phe Ser Ser Arg Gly Tyr Ile 
        355                 360                 365             


Pro Ile Pro Lys Met Glu Ile His Gln Cys Ile Gly Arg Ala Gly Arg 
    370                 375                 380                 


Pro Asn Leu Asp Pro Tyr Gly Glu Gly Ile Ile Tyr Ile Asn Asn Thr 
385                 390                 395                 400 


Glu Asn Pro Glu Leu Ile Glu Asn Ala Lys Asn Tyr Leu Ile Gly Asn 
                405                 410                 415     


Val Glu Glu Ile Tyr Ser Lys Leu Ser Asn Gln Lys Val Leu Arg Thr 
            420                 425                 430         


His Met Leu Gly Leu Ile Thr Thr Gly Asp Ile Lys Asn Lys Asn Asp 
        435                 440                 445             


Leu Glu Glu Phe Ile Lys Asn Thr Phe Tyr Ala Tyr Gln Tyr Gln Asn 
    450                 455                 460                 


Thr Lys Lys Ile Leu Glu Asn Ile Tyr Glu Ile Thr Asn Phe Leu Glu 
465                 470                 475                 480 


Lys Asn Gly Phe Ile Glu Leu Asn Tyr Arg Arg Asp Glu Asn Lys Asp 
                485                 490                 495     


Lys Ser Asn Asn Ser His Asn Asn Lys Lys Asn Ile Ser Asn Thr Asn 
            500                 505                 510         


Asn Ser Ile Lys Met Leu Val Leu Asp Asn Asn Asn Ser Leu Thr Ile 
        515                 520                 525             


Lys Ser Arg His Glu Glu Asp Val Tyr Tyr Asn Ile Thr Pro Leu Gly 
    530                 535                 540                 


Lys Lys Val Ser Glu Leu Tyr Ile Asp Pro Leu Ser Ala Glu Tyr Ile 
545                 550                 555                 560 


Ile Asp Gly Leu Lys Asn Leu His Lys Lys Thr Leu Ser Asn Pro Lys 
                565                 570                 575     


Asn Met Glu Cys Tyr Ile Leu His Ile Leu Tyr Ile Ile Ser Lys Thr 
            580                 585                 590         


Thr Glu Met Gln Pro Val Leu Arg Val Arg Arg Lys Glu Glu Asn Asp 
        595                 600                 605             


Leu Ile Asn Asp Met Ile Lys Leu Asp Ile Asp Val Asp Asp Val Ile 
    610                 615                 620                 


Tyr Gly Ile Ser Ser Glu Asn Leu Glu Tyr Phe Lys Asn Ala Lys Leu 
625                 630                 635                 640 


Phe Tyr Asp Trp Ile Asn Glu Ile Pro Glu Glu Glu Leu Leu Leu Gly 
                645                 650                 655     


Tyr Asn Ile Glu Pro Gly Ile Leu Arg Tyr Asn Val Glu Gln Ala Lys 
            660                 665                 670         


Trp Met Ile His Ser Ala Lys Glu Ile Phe Asn Leu Leu Asn Ile Asp 
        675                 680                 685             


Asn Lys Val Ile Lys Asp Cys Leu Asn Asp Leu Glu Ile Arg Met Glu 
    690                 695                 700                 


Tyr Gly Ala Lys Gln Asp Ile Ile Glu Leu Leu Lys Ile Lys His Ile 
705                 710                 715                 720 


Gly Arg Ala Arg Ala Arg Ile Leu Tyr Asn Ala Gly Ile Lys Asn Ala 
                725                 730                 735     


Asn Asp Ile Ile Asn Asn Gln Lys Asn Ile Ile Asn Leu Leu Gly Glu 
            740                 745                 750         


Lys Ile Ala Arg Lys Ile Leu Ser Glu Leu Gly Val Asp Thr Lys Phe 
        755                 760                 765             


Gly Gln Met Arg Leu Ser Ile 
    770                 775 


<210>  30
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Exemplary Hel308 motif

<400>  30

Gln Cys Ile Gly Arg Ala Gly Arg 
1               5               


<210>  31
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Exemplary extended Hel308 motif

<400>  31

Gln Cys Ile Gly Arg Ala Gly Arg Pro 
1               5                   


<210>  32
<211>  699
<212>  PRT
<213>  Methanotorris igneus

<400>  32

Met Gln Lys Tyr Ser His Val Phe Glu Val Leu Lys Glu Asn Gly Ile 
1               5                   10                  15      


Lys Glu Leu Arg Pro Pro Gln Lys Lys Val Ile Glu Lys Gly Leu Leu 
            20                  25                  30          


Asn Lys Glu Lys Asn Phe Leu Ile Cys Ile Pro Thr Ala Ser Gly Lys 
        35                  40                  45              


Thr Leu Ile Gly Glu Met Ala Leu Ile Asn His Leu Leu Asp Glu Asn 
    50                  55                  60                  


Lys Thr Pro Thr Asn Lys Lys Gly Leu Phe Ile Val Pro Leu Lys Ala 
65                  70                  75                  80  


Leu Ala Ser Glu Lys Tyr Glu Glu Phe Lys Arg Lys Tyr Glu Lys Tyr 
                85                  90                  95      


Gly Leu Lys Val Ala Leu Ser Ile Gly Asp Tyr Asp Glu Lys Glu Asp 
            100                 105                 110         


Leu Ser Ser Tyr Asn Ile Ile Ile Thr Thr Ala Glu Lys Leu Asp Ser 
        115                 120                 125             


Leu Met Arg His Glu Ile Asp Trp Leu Asn Tyr Val Ser Val Ala Ile 
    130                 135                 140                 


Val Asp Glu Ile His Met Ile Asn Asp Glu Lys Arg Gly Gly Thr Leu 
145                 150                 155                 160 


Glu Val Leu Leu Thr Lys Leu Lys Asn Leu Asp Val Gln Ile Ile Gly 
                165                 170                 175     


Leu Ser Ala Thr Ile Gly Asn Pro Glu Glu Leu Ala Glu Trp Leu Asn 
            180                 185                 190         


Ala Glu Leu Ile Ile Asp Asn Trp Arg Pro Val Lys Leu Arg Lys Gly 
        195                 200                 205             


Ile Phe Phe Gln Asn Lys Ile Met Tyr Leu Asn Gly Ala Cys Lys Glu 
    210                 215                 220                 


Leu Pro Asn Phe Ser Asn Asn Pro Met Leu Asn Leu Val Leu Asp Cys 
225                 230                 235                 240 


Val Lys Glu Gly Gly Cys Cys Leu Val Phe Cys Asn Ser Lys Asn Gly 
                245                 250                 255     


Ala Val Ser Glu Ala Lys Lys Leu Asn Leu Lys Lys Tyr Leu Ser Asn 
            260                 265                 270         


Ser Glu Lys Tyr Glu Leu Gln Lys Leu Lys Glu Glu Ile Leu Ser Ile 
        275                 280                 285             


Leu Asp Pro Pro Thr Glu Thr Cys Lys Thr Leu Ala Glu Cys Leu Glu 
    290                 295                 300                 


Lys Gly Val Ala Phe His His Ala Gly Leu Thr Tyr Glu His Arg Lys 
305                 310                 315                 320 


Ile Val Glu Glu Gly Phe Arg Asn Lys Leu Ile Lys Val Ile Cys Cys 
                325                 330                 335     


Thr Pro Thr Leu Ser Ala Gly Ile Asn Ile Pro Cys Arg Arg Ala Ile 
            340                 345                 350         


Val Arg Asp Leu Met Arg Phe Ser Asn Gly Arg Met Lys Pro Ile Pro 
        355                 360                 365             


Ile Met Glu Ile His Gln Cys Ile Gly Arg Ala Gly Arg Pro Gly Leu 
    370                 375                 380                 


Asp Pro Tyr Gly Glu Gly Ile Ile Phe Val Lys Asn Glu Arg Asp Leu 
385                 390                 395                 400 


Glu Arg Ala Glu Gln Tyr Leu Glu Gly Lys Pro Glu Tyr Ile Tyr Ser 
                405                 410                 415     


Lys Leu Ser Asn Gln Ala Val Leu Arg Thr Gln Leu Leu Gly Met Ile 
            420                 425                 430         


Ala Thr Arg Glu Ile Glu Asn Glu Phe Asp Leu Ile Ser Phe Ile Lys 
        435                 440                 445             


Asn Thr Phe Tyr Ala His Gln Tyr Gly Asn Leu Gly Gly Val Leu Arg 
    450                 455                 460                 


Asn Ile Lys Glu Val Ile Asn Phe Leu Glu Glu Asn Asp Phe Ile Ala 
465                 470                 475                 480 


Asp Tyr Phe Pro Thr Lys Leu Gly Lys Arg Val Ser Glu Leu Tyr Ile 
                485                 490                 495     


Asp Pro Leu Ser Ala Lys Ile Ile Ile Asp Gly Leu Lys Glu Met Gly 
            500                 505                 510         


Asn Val Asp Asn Glu Glu Leu Tyr Tyr Leu Tyr Leu Ile Ser Lys Thr 
        515                 520                 525             


Leu Glu Met Met Pro Leu Leu Arg Val Asn Ser Phe Glu Glu Leu Asp 
    530                 535                 540                 


Leu Ile Leu Glu Met Glu Glu Ala Gly Ile Tyr Asp Arg Thr Tyr Asp 
545                 550                 555                 560 


Asp Leu Ala Ala Phe Lys Asn Ala Lys Met Leu Tyr Asp Trp Ile Asn 
                565                 570                 575     


Glu Val Pro Glu Asp Glu Ile Leu Lys Lys Tyr Lys Ile Glu Pro Gly 
            580                 585                 590         


Ile Leu Arg Tyr Lys Val Glu Gln Ala Lys Trp Met Ile Tyr Ser Thr 
        595                 600                 605             


Lys Glu Ile Ala Lys Leu Leu Asn Arg Asn Ile Asp Thr Leu Ser Lys 
    610                 615                 620                 


Leu Glu Ile Arg Leu Glu Tyr Gly Ala Lys Glu Asp Ile Ile Glu Leu 
625                 630                 635                 640 


Leu Lys Ile Lys Tyr Val Gly Arg Ala Arg Ala Arg Lys Leu Tyr Asp 
                645                 650                 655     


Ala Gly Ile Arg Ser Val Glu Asp Ile Ile Asn Asn Pro Lys Lys Val 
            660                 665                 670         


Ala Ser Leu Leu Gly Glu Lys Ile Ala Lys Lys Ile Leu Gly Glu Leu 
        675                 680                 685             


Gly Met Lys Phe Gly Gln Gln Thr Leu Gln Ile 
    690                 695                 


<210>  33
<211>  720
<212>  PRT
<213>  Thermococcus gammatolerans

<400>  33

Met Lys Val Asp Glu Leu Pro Val Asp Glu Arg Leu Lys Ala Val Leu 
1               5                   10                  15      


Lys Glu Arg Gly Ile Glu Glu Leu Tyr Pro Pro Gln Ala Glu Ala Leu 
            20                  25                  30          


Lys Ser Gly Ala Leu Glu Gly Arg Asn Leu Val Leu Ala Ile Pro Thr 
        35                  40                  45              


Ala Ser Gly Lys Thr Leu Val Ser Glu Ile Val Met Val Asn Lys Leu 
    50                  55                  60                  


Ile Gln Glu Gly Gly Lys Ala Val Tyr Leu Val Pro Leu Lys Ala Leu 
65                  70                  75                  80  


Ala Glu Glu Lys Tyr Arg Glu Phe Lys Glu Trp Glu Lys Leu Gly Leu 
                85                  90                  95      


Lys Val Ala Ala Thr Thr Gly Asp Tyr Asp Ser Thr Asp Asp Trp Leu 
            100                 105                 110         


Gly Arg Tyr Asp Ile Ile Val Ala Thr Ala Glu Lys Phe Asp Ser Leu 
        115                 120                 125             


Leu Arg His Gly Ala Arg Trp Ile Asn Asp Val Lys Leu Val Val Ala 
    130                 135                 140                 


Asp Glu Val His Leu Ile Gly Ser Tyr Asp Arg Gly Ala Thr Leu Glu 
145                 150                 155                 160 


Met Ile Leu Thr His Met Leu Gly Arg Ala Gln Ile Leu Ala Leu Ser 
                165                 170                 175     


Ala Thr Val Gly Asn Ala Glu Glu Leu Ala Glu Trp Leu Asp Ala Ser 
            180                 185                 190         


Leu Val Val Ser Asp Trp Arg Pro Val Gln Leu Arg Arg Gly Val Phe 
        195                 200                 205             


His Leu Gly Thr Leu Ile Trp Glu Asp Gly Lys Val Glu Ser Tyr Pro 
    210                 215                 220                 


Glu Asn Trp Tyr Ser Leu Val Val Asp Ala Val Lys Arg Gly Lys Gly 
225                 230                 235                 240 


Ala Leu Val Phe Val Asn Thr Arg Arg Ser Ala Glu Lys Glu Ala Leu 
                245                 250                 255     


Ala Leu Ser Lys Leu Val Ser Ser His Leu Thr Lys Pro Glu Lys Arg 
            260                 265                 270         


Ala Leu Glu Ser Leu Ala Ser Gln Leu Glu Asp Asn Pro Thr Ser Glu 
        275                 280                 285             


Lys Leu Lys Arg Ala Leu Arg Gly Gly Val Ala Phe His His Ala Gly 
    290                 295                 300                 


Leu Ser Arg Val Glu Arg Thr Leu Ile Glu Asp Ala Phe Arg Glu Gly 
305                 310                 315                 320 


Leu Ile Lys Val Ile Thr Ala Thr Pro Thr Leu Ser Ala Gly Val Asn 
                325                 330                 335     


Leu Pro Ser Phe Arg Val Ile Ile Arg Asp Thr Lys Arg Tyr Ala Gly 
            340                 345                 350         


Phe Gly Trp Thr Asp Ile Pro Val Leu Glu Ile Gln Gln Met Met Gly 
        355                 360                 365             


Arg Ala Gly Arg Pro Arg Tyr Asp Lys Tyr Gly Glu Ala Ile Ile Val 
    370                 375                 380                 


Ala Arg Thr Asp Glu Pro Gly Lys Leu Met Glu Arg Tyr Ile Arg Gly 
385                 390                 395                 400 


Lys Pro Glu Lys Leu Phe Ser Met Leu Ala Asn Glu Gln Ala Phe Arg 
                405                 410                 415     


Ser Gln Val Leu Ala Leu Ile Thr Asn Phe Gly Ile Arg Ser Phe Pro 
            420                 425                 430         


Glu Leu Val Arg Phe Leu Glu Arg Thr Phe Tyr Ala His Gln Arg Lys 
        435                 440                 445             


Asp Leu Ser Ser Leu Glu Tyr Lys Ala Lys Glu Val Val Tyr Phe Leu 
    450                 455                 460                 


Ile Glu Asn Glu Phe Ile Asp Leu Asp Leu Glu Asp Arg Phe Ile Pro 
465                 470                 475                 480 


Leu Pro Phe Gly Lys Arg Thr Ser Gln Leu Tyr Ile Asp Pro Leu Thr 
                485                 490                 495     


Ala Lys Lys Phe Lys Asp Ala Phe Pro Ala Ile Glu Arg Asn Pro Asn 
            500                 505                 510         


Pro Phe Gly Ile Phe Gln Leu Ile Ala Ser Thr Pro Asp Met Ala Thr 
        515                 520                 525             


Leu Thr Ala Arg Arg Arg Glu Met Glu Asp Tyr Leu Asp Leu Ala Tyr 
    530                 535                 540                 


Glu Leu Glu Asp Lys Leu Tyr Ala Ser Ile Pro Tyr Tyr Glu Asp Ser 
545                 550                 555                 560 


Arg Phe Gln Gly Phe Leu Gly Gln Val Lys Thr Ala Lys Val Leu Leu 
                565                 570                 575     


Asp Trp Ile Asn Glu Val Pro Glu Ala Arg Ile Tyr Glu Thr Tyr Ser 
            580                 585                 590         


Ile Asp Pro Gly Asp Leu Tyr Arg Leu Leu Glu Leu Ala Asp Trp Leu 
        595                 600                 605             


Met Tyr Ser Leu Ile Glu Leu Tyr Lys Leu Phe Glu Pro Lys Glu Glu 
    610                 615                 620                 


Ile Leu Asn Tyr Leu Arg Asp Leu His Leu Arg Leu Arg His Gly Val 
625                 630                 635                 640 


Arg Glu Glu Leu Leu Glu Leu Val Arg Leu Pro Asn Ile Gly Arg Lys 
                645                 650                 655     


Arg Ala Arg Ala Leu Tyr Asn Ala Gly Phe Arg Ser Val Glu Ala Ile 
            660                 665                 670         


Ala Asn Ala Lys Pro Ala Glu Leu Leu Ala Val Glu Gly Ile Gly Ala 
        675                 680                 685             


Lys Ile Leu Asp Gly Ile Tyr Arg His Leu Gly Ile Glu Lys Arg Val 
    690                 695                 700                 


Thr Glu Glu Lys Pro Lys Arg Lys Gly Thr Leu Glu Asp Phe Leu Arg 
705                 710                 715                 720 


<210>  34
<211>  755
<212>  PRT
<213>  Thermococcus barophilus

<400>  34

Met Leu Ser Thr Lys Pro Lys Ala Tyr Lys Arg Phe Ser Pro Ile Gly 
1               5                   10                  15      


Tyr Ala Met Gln Val Asp Glu Leu Ser Lys Phe Gly Val Asp Glu Arg 
            20                  25                  30          


Ile Ile Arg Lys Ile Lys Glu Arg Gly Ile Ser Glu Phe Tyr Pro Pro 
        35                  40                  45              


Gln Ala Glu Ala Leu Arg Ser Gly Val Leu Asn Gly Glu Asn Leu Leu 
    50                  55                  60                  


Leu Ala Ile Pro Thr Ala Ser Gly Lys Thr Leu Val Ala Glu Ile Val 
65                  70                  75                  80  


Met Leu His Lys Leu Phe Thr Gly Gly Gly Lys Ala Val Tyr Leu Val 
                85                  90                  95      


Pro Leu Lys Ala Leu Ala Glu Glu Lys Tyr Arg Glu Phe Lys Thr Trp 
            100                 105                 110         


Glu Asp Leu Gly Val Arg Val Ala Val Thr Thr Gly Asp Tyr Asp Ser 
        115                 120                 125             


Ser Glu Glu Trp Leu Gly Lys Tyr Asp Ile Ile Ile Ala Thr Ser Glu 
    130                 135                 140                 


Lys Phe Asp Ser Leu Leu Arg His Lys Ser Arg Trp Ile Arg Asp Val 
145                 150                 155                 160 


Thr Leu Ile Val Ala Asp Glu Ile His Leu Leu Gly Ser Tyr Asp Arg 
                165                 170                 175     


Gly Ala Thr Leu Glu Met Ile Leu Ser His Met Leu Gly Lys Ala Gln 
            180                 185                 190         


Ile Leu Gly Leu Ser Ala Thr Val Gly Asn Ala Glu Glu Leu Ala Glu 
        195                 200                 205             


Trp Leu Asn Ala Lys Leu Val Val Ser Asp Trp Arg Pro Val Lys Leu 
    210                 215                 220                 


Arg Lys Gly Val Phe Ala His Gly Gln Leu Ile Trp Glu Asp Gly Lys 
225                 230                 235                 240 


Val Asp Lys Phe Pro Pro Gln Trp Asp Ser Leu Val Ile Asp Ala Val 
                245                 250                 255     


Lys Lys Gly Lys Gln Ala Leu Val Phe Val Asn Thr Arg Arg Ser Ala 
            260                 265                 270         


Glu Lys Glu Ala Gly Met Leu Gly Lys Lys Val Arg Arg Leu Leu Thr 
        275                 280                 285             


Lys Pro Glu Ala Arg Arg Leu Lys Glu Leu Ala Glu Ser Leu Glu Ser 
    290                 295                 300                 


Asn Pro Thr Asn Asp Lys Leu Lys Glu Val Leu Val Asn Gly Ala Ala 
305                 310                 315                 320 


Phe His His Ala Gly Leu Gly Arg Ala Glu Arg Thr Leu Ile Glu Asp 
                325                 330                 335     


Ala Phe Arg Glu Gly Leu Ile Lys Val Leu Thr Ala Thr Pro Thr Leu 
            340                 345                 350         


Ala Met Gly Val Asn Leu Pro Ser Phe Arg Val Ile Ile Arg Asp Thr 
        355                 360                 365             


Lys Arg Tyr Ser Thr Phe Gly Trp Ser Asp Ile Pro Val Leu Glu Ile 
    370                 375                 380                 


Gln Gln Met Ile Gly Arg Ala Gly Arg Pro Lys Tyr Asp Lys Glu Gly 
385                 390                 395                 400 


Glu Ala Ile Ile Val Ala Lys Thr Glu Lys Pro Glu Glu Leu Met Glu 
                405                 410                 415     


Lys Tyr Ile Phe Gly Lys Pro Glu Lys Leu Phe Ser Met Leu Ser Asn 
            420                 425                 430         


Asp Ala Ala Phe Arg Ser Gln Val Leu Ala Leu Ile Thr Asn Phe Gly 
        435                 440                 445             


Val Glu Ser Phe Arg Glu Leu Ile Gly Phe Leu Glu Lys Thr Phe Tyr 
    450                 455                 460                 


Tyr His Gln Arg Lys Asp Leu Glu Ile Leu Glu Gly Lys Ala Lys Ser 
465                 470                 475                 480 


Ile Val Tyr Phe Leu Leu Glu Asn Glu Phe Ile Asp Ile Asp Leu Asn 
                485                 490                 495     


Asp Ser Phe Ile Ala Leu Pro Phe Gly Ile Arg Thr Ser Gln Leu Tyr 
            500                 505                 510         


Leu Asp Pro Leu Thr Ala Lys Lys Phe Lys Asp Ala Leu Pro Gln Ile 
        515                 520                 525             


Glu Glu Asn Pro Asn Pro Leu Gly Ile Phe Gln Leu Leu Ala Ser Thr 
    530                 535                 540                 


Pro Asp Met Gly Thr Leu Ser Ile Lys Arg Lys Glu Gln Glu Ser Tyr 
545                 550                 555                 560 


Leu Asp Tyr Ala Tyr Glu Met Glu Asp Tyr Leu Tyr Arg Ser Ile Pro 
                565                 570                 575     


Tyr Trp Glu Asp Tyr Glu Phe Gln Lys Phe Leu Ser Glu Val Lys Thr 
            580                 585                 590         


Ala Lys Leu Leu Leu Asp Trp Ile Asn Glu Val Ser Glu Ala Lys Leu 
        595                 600                 605             


Ile Glu Ala Tyr Gly Ile Asp Thr Gly Asp Leu Tyr Arg Ile Ile Glu 
    610                 615                 620                 


Leu Ala Asp Trp Leu Met Tyr Ser Leu Ile Glu Leu Ala Lys Val Leu 
625                 630                 635                 640 


Asn Ala Gly Gly Glu Thr Ile Lys Tyr Leu Arg Arg Leu His Leu Arg 
                645                 650                 655     


Leu Lys His Gly Val Arg Glu Glu Leu Leu Glu Leu Val Glu Leu Pro 
            660                 665                 670         


Met Ile Gly Arg Arg Arg Ala Arg Ala Leu Tyr Asn Ala Gly Phe Lys 
        675                 680                 685             


Asn Val Asn Asp Ile Val Lys Ala Lys Pro Ser Glu Leu Leu Ala Val 
    690                 695                 700                 


Glu Gly Ile Gly Val Lys Val Leu Glu Arg Ile Tyr Arg His Phe Gly 
705                 710                 715                 720 


Val Glu Leu Pro Leu Leu Lys Asn Ile Lys Asp Pro Asp Lys Pro Glu 
                725                 730                 735     


Asp Lys Pro Lys Glu Lys Pro Lys Pro Lys Lys Gly Thr Leu Asp Tyr 
            740                 745                 750         


Phe Leu Lys 
        755 


<210>  35
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Exemplary Hel308 motif

<400>  35

Gln Met Ile Gly Arg Ala Gly Arg 
1               5               


<210>  36
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Exemplary extended Hel308 motif

<400>  36

Gln Met Ile Gly Arg Ala Gly Arg Pro 
1               5                   


<210>  37
<211>  744
<212>  PRT
<213>  Thermococcus sibiricus

<400>  37

Met Lys Leu Asn Lys Leu Lys Ser Tyr Ile Asn Ala Phe Leu Leu Gly 
1               5                   10                  15      


Met Val Met Ser Met Lys Val Asp Glu Leu Lys Ser Leu Gly Val Asp 
            20                  25                  30          


Glu Arg Ile Leu Arg Leu Leu Arg Glu Arg Gly Ile Glu Glu Leu Tyr 
        35                  40                  45              


Pro Pro Gln Ala Asp Ala Leu Lys Thr Glu Val Leu Lys Gly Lys Asn 
    50                  55                  60                  


Leu Val Leu Ala Ile Pro Thr Ala Ser Gly Lys Thr Leu Val Ala Glu 
65                  70                  75                  80  


Ile Val Met Ile Asn Lys Ile Leu Arg Glu Gly Gly Lys Thr Val Tyr 
                85                  90                  95      


Leu Val Pro Leu Lys Ala Leu Ala Glu Glu Lys Tyr Lys Glu Phe Lys 
            100                 105                 110         


Phe Trp Glu Lys Leu Gly Ile Arg Ile Ala Met Thr Thr Gly Asp Tyr 
        115                 120                 125             


Asp Ser Thr Glu Glu Trp Leu Gly Lys Tyr Asp Ile Ile Ile Ala Thr 
    130                 135                 140                 


Ser Glu Lys Phe Asp Ser Leu Leu Arg His Lys Ser Pro Trp Ile Lys 
145                 150                 155                 160 


Asp Ile Asn Leu Val Ile Ala Asp Glu Ile His Leu Leu Gly Ser Tyr 
                165                 170                 175     


Asp Arg Gly Ala Thr Leu Glu Met Ile Leu Ala His Leu Asp Asp Lys 
            180                 185                 190         


Ala Gln Ile Leu Gly Leu Ser Ala Thr Val Gly Asn Ala Glu Glu Val 
        195                 200                 205             


Ala Glu Trp Leu Asn Ala Asp Leu Val Met Ser Glu Trp Arg Pro Val 
    210                 215                 220                 


Ala Leu Arg Lys Gly Val Phe Tyr His Gly Glu Leu Phe Trp Glu Asp 
225                 230                 235                 240 


Gly Ser Ile Glu Arg Phe Pro Thr Gln Trp Asp Ser Leu Val Ile Asp 
                245                 250                 255     


Ala Leu Lys Lys Gly Lys Gln Ala Leu Val Phe Val Asn Thr Arg Arg 
            260                 265                 270         


Ser Ala Glu Lys Glu Ala Leu Leu Leu Ala Gly Lys Ile Gln Arg Phe 
        275                 280                 285             


Leu Thr Lys Pro Glu Glu Arg Lys Leu Lys Gln Leu Ala Asp Gly Leu 
    290                 295                 300                 


Asp Thr Thr Pro Thr Asn Gln Lys Leu Lys Glu Ala Leu Thr Lys Gly 
305                 310                 315                 320 


Val Ala Phe His His Ala Gly Leu Gly Arg Thr Glu Arg Ser Ile Ile 
                325                 330                 335     


Glu Asp Ala Phe Arg Glu Gly Leu Ile Lys Val Ile Thr Ala Thr Pro 
            340                 345                 350         


Thr Leu Ser Ala Gly Val Asn Leu Pro Ala Tyr Arg Val Ile Ile Arg 
        355                 360                 365             


Asp Thr Lys Arg Tyr Ser Asn Phe Gly Trp Val Asp Ile Pro Val Leu 
    370                 375                 380                 


Glu Ile Gln Gln Met Met Gly Arg Ala Gly Arg Pro Lys Tyr Asp Ile 
385                 390                 395                 400 


Glu Gly Gln Ala Ile Ile Ile Ala Lys Thr Glu Lys Pro Glu Asp Leu 
                405                 410                 415     


Met Lys Arg Tyr Val Leu Gly Lys Pro Glu Lys Leu Phe Ser Met Leu 
            420                 425                 430         


Ser Asn Glu Ala Ser Phe Arg Ser Gln Val Leu Ala Leu Ile Thr Asn 
        435                 440                 445             


Phe Gly Val Gly Asn Phe Lys Glu Leu Val Asn Phe Leu Glu Arg Thr 
    450                 455                 460                 


Phe Tyr Tyr His Gln Arg Lys Asn Leu Glu Ala Leu Glu Gly Lys Ala 
465                 470                 475                 480 


Lys Ser Ile Val Tyr Phe Leu Phe Glu Asn Glu Phe Ile Asp Ile Asp 
                485                 490                 495     


Leu Asn Asp Gln Phe Met Pro Leu Pro Leu Gly Ile Arg Thr Ser Gln 
            500                 505                 510         


Leu Tyr Leu Asp Pro Val Thr Ala Lys Lys Phe Lys Asp Ala Phe Glu 
        515                 520                 525             


Lys Leu Glu Lys Asn Pro Asn Pro Leu Gly Ile Phe Gln Leu Leu Ala 
    530                 535                 540                 


Ser Thr Pro Asp Met Ser Ser Leu Arg Val Lys Arg Lys Glu Gln Glu 
545                 550                 555                 560 


Asp Leu Leu Asp Tyr Ala Tyr Glu Met Glu Glu Tyr Leu Tyr Gln Asn 
                565                 570                 575     


Ile Pro Tyr Trp Glu Asp Tyr Lys Phe Glu Lys Phe Leu Gly Glu Thr 
            580                 585                 590         


Lys Thr Ala Lys Leu Leu Leu Asp Trp Ile Asn Glu Val Asn Asp Val 
        595                 600                 605             


Lys Ile Leu Glu Thr Tyr Glu Ile Asp Thr Gly Asp Leu Tyr Arg Ile 
    610                 615                 620                 


Leu Glu Leu Val Asp Trp Leu Met Tyr Ser Leu Ile Glu Leu Tyr Lys 
625                 630                 635                 640 


Leu Phe Asp Pro Lys Pro Glu Val Leu Asp Phe Leu Lys Lys Leu His 
                645                 650                 655     


Ile Arg Val Lys His Gly Val Arg Glu Glu Leu Leu Glu Leu Ile Thr 
            660                 665                 670         


Leu Pro Met Ile Gly Arg Lys Arg Ala Arg Ala Leu Tyr Asn Ala Gly 
        675                 680                 685             


Phe Lys Gly Ile Asp Asp Ile Val Arg Ala Lys Ala Ser Glu Leu Leu 
    690                 695                 700                 


Lys Val Glu Gly Ile Gly Ile Gly Val Ile Glu Lys Ile Tyr Gln His 
705                 710                 715                 720 


Phe Gly Val Glu Leu Pro Thr Asn Glu Lys Lys Lys Lys Val Lys Lys 
                725                 730                 735     


Gly Thr Leu Asp Glu Phe Phe Lys 
            740                 


<210>  38
<211>  729
<212>  PRT
<213>  Methanosarcina barkeri fusaro

<400>  38

Met Lys Ile Glu Ser Leu Asp Leu Pro Asp Glu Val Lys Gln Phe Tyr 
1               5                   10                  15      


Leu Asn Ser Gly Ile Met Glu Leu Tyr Pro Pro Gln Ala Glu Ala Val 
            20                  25                  30          


Glu Lys Gly Leu Leu Glu Gly Arg Asn Leu Leu Ala Ala Ile Pro Thr 
        35                  40                  45              


Ala Ser Gly Lys Thr Leu Leu Ala Glu Leu Ala Met Leu Lys Ser Ile 
    50                  55                  60                  


Leu Ala Gly Gly Lys Ala Leu Tyr Ile Val Pro Leu Arg Ala Leu Ala 
65                  70                  75                  80  


Ser Glu Lys Phe Arg Arg Phe Arg Glu Phe Ser Glu Leu Gly Ile Arg 
                85                  90                  95      


Val Gly Ile Ser Thr Gly Asp Tyr Asp Leu Arg Asp Glu Gly Leu Gly 
            100                 105                 110         


Val Asn Asp Ile Ile Val Ala Thr Ser Glu Lys Thr Asp Ser Leu Leu 
        115                 120                 125             


Arg Asn Glu Thr Val Trp Met Gln Glu Ile Ser Val Val Val Ala Asp 
    130                 135                 140                 


Glu Val His Leu Ile Asp Ser Pro Asp Arg Gly Pro Thr Leu Glu Val 
145                 150                 155                 160 


Thr Leu Ala Lys Leu Arg Lys Met Asn Pro Ser Cys Gln Ile Leu Ala 
                165                 170                 175     


Leu Ser Ala Thr Val Gly Asn Ala Asp Glu Leu Ala Val Trp Leu Glu 
            180                 185                 190         


Ala Glu Leu Val Val Ser Glu Trp Arg Pro Thr Glu Leu Leu Glu Gly 
        195                 200                 205             


Val Phe Phe Asn Gly Thr Phe Tyr Cys Lys Asp Arg Glu Lys Thr Val 
    210                 215                 220                 


Glu Gln Ser Thr Lys Asp Glu Ala Val Asn Leu Ala Leu Asp Thr Leu 
225                 230                 235                 240 


Lys Lys Asp Gly Gln Cys Leu Val Phe Glu Ser Ser Arg Lys Asn Cys 
                245                 250                 255     


Met Ala Phe Ala Lys Lys Ala Ala Ser Thr Val Lys Lys Thr Leu Ser 
            260                 265                 270         


Ala Glu Asp Arg Asn Ala Leu Ala Gly Ile Ala Asp Glu Ile Leu Glu 
        275                 280                 285             


Asn Ser Glu Thr Asp Thr Ser Thr Asn Leu Ala Val Cys Ile Arg Ser 
    290                 295                 300                 


Gly Thr Ala Phe His His Ala Gly Leu Thr Thr Pro Leu Arg Glu Leu 
305                 310                 315                 320 


Val Glu Asp Gly Phe Arg Ala Gly Arg Ile Lys Leu Ile Ser Ser Thr 
                325                 330                 335     


Pro Thr Leu Ala Ala Gly Leu Asn Leu Pro Ala Arg Arg Val Ile Ile 
            340                 345                 350         


Arg Asn Tyr Arg Arg Tyr Ser Ser Glu Asp Gly Met Gln Pro Ile Pro 
        355                 360                 365             


Val Leu Glu Tyr Lys Gln Met Ala Gly Arg Ala Gly Arg Pro Arg Leu 
    370                 375                 380                 


Asp Pro Tyr Gly Glu Ala Val Leu Val Ala Lys Ser Tyr Lys Glu Phe 
385                 390                 395                 400 


Val Phe Leu Phe Glu Asn Tyr Ile Glu Ala Asn Ala Glu Asp Ile Trp 
                405                 410                 415     


Ser Lys Leu Gly Thr Glu Asn Ala Leu Arg Thr His Val Leu Ser Thr 
            420                 425                 430         


Ile Ser Asn Gly Phe Ala Arg Thr Tyr Asp Glu Leu Met Asp Phe Leu 
        435                 440                 445             


Glu Ala Thr Phe Phe Ala Phe Gln Tyr Ser Asn Phe Gly Leu Ser Thr 
    450                 455                 460                 


Val Val Asn Glu Cys Leu Asn Phe Leu Arg Gln Glu Gly Met Leu Glu 
465                 470                 475                 480 


Lys Asp Asp Ala Leu Ile Pro Thr Ser Phe Gly Lys Leu Val Ser Arg 
                485                 490                 495     


Leu Tyr Ile Asp Pro Leu Ser Ala Ala Arg Ile Ala Lys Gly Leu Lys 
            500                 505                 510         


Gly Ala Lys Ser Leu Ser Glu Leu Thr Leu Leu His Leu Val Cys Ser 
        515                 520                 525             


Thr Pro Asp Met Arg Leu Leu Tyr Met Arg Ser His Asp Tyr Gln Asp 
    530                 535                 540                 


Ile Asn Asp Tyr Val Met Ala His Ala Ser Glu Phe Val Lys Val Pro 
545                 550                 555                 560 


Ser Pro Phe Asp Thr Thr Glu Tyr Glu Trp Phe Leu Gly Glu Val Lys 
                565                 570                 575     


Thr Ser Leu Leu Leu Leu Asp Trp Ile His Glu Lys Ser Glu Asn Glu 
            580                 585                 590         


Ile Cys Leu Lys Phe Gly Thr Gly Glu Gly Asp Ile His Ser Ile Ala 
        595                 600                 605             


Asp Ile Ala Glu Trp Ile Met His Val Thr Ser Gln Leu Ala Gly Leu 
    610                 615                 620                 


Leu Asp Leu Lys Gly Ala Arg Glu Ala Ala Glu Leu Glu Lys Arg Ile 
625                 630                 635                 640 


His Tyr Gly Ala Ala Pro Glu Leu Ile Asp Leu Leu Asn Ile Arg Gly 
                645                 650                 655     


Ile Gly Arg Val Arg Ala Arg Lys Leu Tyr Glu Ala Gly Phe Lys Ser 
            660                 665                 670         


Ser Ala Glu Leu Ala Glu Val Asp Pro Glu Lys Val Ala Ala Leu Leu 
        675                 680                 685             


Gly Pro Lys Ile Ala Asp Arg Ile Phe Lys Gln Ile Arg Gly Arg Gly 
    690                 695                 700                 


Thr Ser Ser Gly Ile Ile Ala Ser Glu Pro Pro Glu Lys Ser Pro Tyr 
705                 710                 715                 720 


Ser Gly Gln Lys Thr Ile Ser Asp Tyr 
                725                 


<210>  39
<211>  730
<212>  PRT
<213>  Methanosarcina acetivorans

<400>  39

Met Lys Ile Glu Ser Leu Asp Leu Pro Asp Glu Val Lys Arg Phe Tyr 
1               5                   10                  15      


Glu Asn Ser Gly Ile Pro Glu Leu Tyr Pro Pro Gln Ala Glu Ala Val 
            20                  25                  30          


Glu Lys Gly Leu Leu Glu Gly Lys Asn Leu Leu Ala Ala Ile Pro Thr 
        35                  40                  45              


Ala Ser Gly Lys Thr Leu Leu Ala Glu Leu Ala Met Leu Lys Ser Val 
    50                  55                  60                  


Leu Ala Gly Gly Lys Ala Leu Tyr Ile Val Pro Leu Arg Ala Leu Ala 
65                  70                  75                  80  


Ser Glu Lys Phe Arg Arg Phe Gln Asp Phe Ser Glu Leu Gly Ile Arg 
                85                  90                  95      


Val Gly Ile Ser Thr Gly Asp Tyr Asp Arg Arg Asp Glu Gly Leu Gly 
            100                 105                 110         


Ile Asn Asp Ile Ile Val Ala Thr Ser Glu Lys Thr Asp Ser Leu Leu 
        115                 120                 125             


Arg Asn Glu Thr Ala Trp Met Gln Glu Ile Ser Val Val Val Val Asp 
    130                 135                 140                 


Glu Val His Leu Ile Asp Ser Ala Asp Arg Gly Pro Thr Leu Glu Val 
145                 150                 155                 160 


Thr Leu Ala Lys Leu Arg Lys Met Asn Pro Phe Cys Gln Ile Leu Ala 
                165                 170                 175     


Leu Ser Ala Thr Val Gly Asn Ala Asp Glu Leu Ala Ala Trp Leu Asp 
            180                 185                 190         


Ala Glu Leu Val Leu Ser Glu Trp Arg Pro Thr Asp Leu Met Glu Gly 
        195                 200                 205             


Val Phe Phe Asp Gly Thr Phe Phe Cys Lys Asp Lys Glu Lys Leu Ile 
    210                 215                 220                 


Glu Gln Pro Thr Lys Asp Glu Ala Ile Asn Leu Val Leu Asp Thr Leu 
225                 230                 235                 240 


Arg Glu Gly Gly Gln Cys Leu Val Phe Glu Ser Ser Arg Lys Asn Cys 
                245                 250                 255     


Met Gly Phe Ala Lys Lys Ala Thr Ser Ala Val Lys Lys Thr Leu Ser 
            260                 265                 270         


Ala Glu Asp Lys Glu Lys Leu Ala Gly Ile Ala Asp Glu Ile Leu Glu 
        275                 280                 285             


Asn Ser Glu Thr Asp Thr Ala Ser Val Leu Ala Ser Cys Val Arg Ala 
    290                 295                 300                 


Gly Thr Ala Phe His His Ala Gly Leu Thr Ser Pro Leu Arg Glu Leu 
305                 310                 315                 320 


Val Glu Thr Gly Phe Arg Glu Gly Tyr Val Lys Leu Ile Ser Ser Thr 
                325                 330                 335     


Pro Thr Leu Ala Ala Gly Leu Asn Leu Pro Ala Arg Arg Val Ile Ile 
            340                 345                 350         


Arg Ser Tyr Arg Arg Tyr Ser Ser Asp Ser Gly Met Gln Pro Ile Pro 
        355                 360                 365             


Val Leu Glu Tyr Lys Gln Met Ala Gly Arg Ala Gly Arg Pro Arg Leu 
    370                 375                 380                 


Asp Pro Tyr Gly Glu Ala Val Leu Leu Ala Lys Ser Tyr Glu Glu Leu 
385                 390                 395                 400 


Leu Phe Leu Phe Glu Lys Tyr Ile Glu Ala Gly Ala Glu Asp Ile Trp 
                405                 410                 415     


Ser Lys Leu Gly Thr Glu Asn Ala Leu Arg Thr His Val Leu Ser Thr 
            420                 425                 430         


Ile Ser Asn Gly Phe Ala Arg Thr Lys Glu Glu Leu Met Asp Phe Leu 
        435                 440                 445             


Glu Ala Thr Phe Phe Ala Tyr Gln Tyr Ser Asn Phe Gly Leu Ser Val 
    450                 455                 460                 


Val Val Asp Glu Cys Leu Asn Phe Leu Arg Gln Glu Gly Met Leu Glu 
465                 470                 475                 480 


Gln Asp Ser Asp Ala Leu Ile Ser Thr Met Phe Gly Lys Leu Val Ser 
                485                 490                 495     


Arg Leu Tyr Ile Asp Pro Leu Ser Ala Ala Leu Ile Ala Lys Gly Leu 
            500                 505                 510         


Arg Glu Ala Gly Thr Leu Thr Glu Leu Thr Leu Leu His Leu Val Cys 
        515                 520                 525             


Ser Thr Pro Asp Met Arg Leu Met Tyr Met Arg Ser Gln Asp Tyr Gln 
    530                 535                 540                 


Asp Ile Asn Asp Phe Val Met Ala His Ala Glu Glu Phe Ser Lys Val 
545                 550                 555                 560 


Pro Ser Pro Phe Asn Ile Val Glu Tyr Glu Trp Phe Leu Ser Glu Val 
                565                 570                 575     


Lys Thr Ser Leu Leu Leu Met Asp Trp Ile His Glu Lys Pro Glu Asn 
            580                 585                 590         


Glu Ile Cys Leu Lys Phe Gly Thr Gly Glu Gly Asp Ile His Thr Thr 
        595                 600                 605             


Ala Asp Ile Ala Glu Trp Ile Met His Val Ala Thr Gln Leu Ala Arg 
    610                 615                 620                 


Leu Leu Asp Leu Lys Gly Ala Lys Glu Ala Ala Glu Leu Glu Lys Arg 
625                 630                 635                 640 


Ile His Tyr Gly Ala Gly Pro Glu Leu Met Asp Leu Leu Asp Ile Arg 
                645                 650                 655     


Gly Ile Gly Arg Val Arg Ala Arg Lys Leu Tyr Gly Ala Gly Phe Lys 
            660                 665                 670         


Ser Thr Ala Asp Leu Ala Gly Ala Thr Pro Glu Lys Val Ala Ala Leu 
        675                 680                 685             


Val Gly Pro Lys Ile Ala Glu Arg Ile Phe Arg Gln Ile Gly Arg Arg 
    690                 695                 700                 


Glu Ala Val Ser Glu Ile Ser Asp Ser Glu Arg Leu Glu Lys Ser Ser 
705                 710                 715                 720 


Gln Asp Gly Gln Ser Thr Ile Ser Asp Phe 
                725                 730 


<210>  40
<211>  729
<212>  PRT
<213>  Methanohalophilus mahii

<400>  40

Met Lys Ile Glu Glu Leu Asp Leu Pro Ser Glu Ala Ile Glu Val Tyr 
1               5                   10                  15      


Leu Gln Ala Gly Ile Glu Glu Leu Tyr Pro Pro Gln Ala Asp Ala Val 
            20                  25                  30          


Glu Lys Gly Leu Leu Gln Gly Glu Asn Leu Leu Ala Ala Ile Pro Thr 
        35                  40                  45              


Ala Ser Gly Lys Thr Leu Leu Ala Glu Met Ala Met Leu Lys Ala Ile 
    50                  55                  60                  


Lys Lys Gly Gly Lys Ala Leu Tyr Ile Val Pro Leu Arg Ala Leu Ala 
65                  70                  75                  80  


Ser Glu Lys Phe Arg Asp Phe Lys Arg Phe Glu Ser Leu Gly Ile Lys 
                85                  90                  95      


Thr Ala Ile Ser Thr Gly Asp Phe Asp Ser Arg Asp Glu Trp Leu Gly 
            100                 105                 110         


Ser Asn Asp Ile Ile Val Ala Thr Ser Glu Lys Thr Asp Ser Leu Leu 
        115                 120                 125             


Arg Asn Ser Thr Pro Trp Met Lys Asp Ile Thr Ala Val Ile Val Asp 
    130                 135                 140                 


Glu Val His Leu Leu Asp Ser Ala Asn Arg Gly Pro Thr Leu Glu Val 
145                 150                 155                 160 


Thr Leu Ala Lys Leu Lys Arg Leu Asn Pro Gly Ala Gln Val Val Ala 
                165                 170                 175     


Leu Ser Ala Thr Val Gly Asn Ala Met Glu Ile Ala Gln Trp Leu Glu 
            180                 185                 190         


Ala Lys Leu Val Leu Ser Glu Trp Arg Pro Thr Tyr Leu His Glu Gly 
        195                 200                 205             


Ile Phe Tyr Gly Asp Ala Ile Asn Phe Asp Glu Asp Gln Thr Phe Ile 
    210                 215                 220                 


Glu Arg Arg His Lys Glu Asp Ser Val Asn Leu Val Ile Asp Thr Val 
225                 230                 235                 240 


Ile Gln Gly Gly Gln Cys Leu Val Phe Asp Ser Ser Arg Arg Asn Cys 
                245                 250                 255     


Val Gly Phe Ala Lys Lys Cys Ala Pro Ala Val Gly Glu Leu Leu Asp 
            260                 265                 270         


Arg Gln Asn Arg Asn Glu Leu Glu Glu Val Ala Lys Glu Val Leu Glu 
        275                 280                 285             


Asn Gly Glu Thr Lys Leu Thr Glu Thr Leu Ala Tyr Cys Ile Lys Lys 
    290                 295                 300                 


Gly Val Ala Phe His His Ala Gly Leu Asn Ser Ala His Arg Arg Ile 
305                 310                 315                 320 


Val Glu Asp Ala Phe Arg Asn Asn Leu Ile Lys Met Ile Cys Ser Thr 
                325                 330                 335     


Pro Thr Leu Ala Ala Gly Leu Asn Leu Pro Ala Arg Arg Val Ile Ile 
            340                 345                 350         


Arg Ser Tyr Lys Arg Tyr Asp Pro Asn Ala Gly Met Gln Pro Ile Pro 
        355                 360                 365             


Val Leu Asp Tyr Lys Gln Met Ala Gly Arg Ala Gly Arg Pro His Leu 
    370                 375                 380                 


Asp Pro Tyr Gly Glu Ala Val Val Ile Val Lys Thr Tyr Glu Glu Phe 
385                 390                 395                 400 


Thr Asp Val Leu Glu Arg Tyr Ile Ser Ala Ser Ala Glu Asp Ile Trp 
                405                 410                 415     


Ser Lys Leu Gly Thr Glu Asn Ala Leu Arg Thr His Ile Leu Ser Thr 
            420                 425                 430         


Ile Ala Ser Gly Phe Ala Asn Cys His Arg Glu Ile Leu Thr Phe Leu 
        435                 440                 445             


Gly Ser Thr Phe Phe Ala His Gln Gln Gln Ser Trp Asn Phe Glu Glu 
    450                 455                 460                 


Leu Leu Glu Asp Cys Leu Ile Phe Leu Lys Asn Glu Gly Met Leu Glu 
465                 470                 475                 480 


Gln Asp Asn Glu Thr Ile Arg Ala Thr Glu Leu Gly Lys Met Ile Ser 
                485                 490                 495     


Ser Leu Tyr Ile Asp Pro Leu Ser Ala Ser Lys Ile Ile Arg Gly Leu 
            500                 505                 510         


Glu Lys Thr Thr His Val Thr Asp Met Thr Leu Leu Gln Leu Ile Cys 
        515                 520                 525             


Ser Thr Pro Asp Met Arg Leu Leu Tyr Leu Arg Asn Arg Asp Tyr Glu 
    530                 535                 540                 


Ile Ile Asn Asp Tyr Val Met Asn His Thr Glu Glu Phe Ile Glu Val 
545                 550                 555                 560 


Pro Ser Pro Phe Lys Gln Ile Glu Tyr Glu Trp Phe Leu Ser Glu Val 
                565                 570                 575     


Lys Thr Ala Leu Leu Leu Leu Glu Trp Ile Asn Glu Lys Ser Leu Glu 
            580                 585                 590         


Lys Ile Val Glu Asn Tyr Gln Val Gly Glu Gly Asp Ile Tyr Ala Ser 
        595                 600                 605             


Ser Asp Ile Ala Glu Trp Leu Met His Ala Thr Gln Arg Ile Ala Ser 
    610                 615                 620                 


Arg Ile Asn Pro Gln Leu Glu Thr Glu Cys Ala Lys Leu Glu Lys Arg 
625                 630                 635                 640 


Ile His Tyr Gly Ala Gly Ser Glu Leu Ile Glu Leu Val Glu Ile Pro 
                645                 650                 655     


Asn Val Gly Arg Ala Arg Ala Arg Lys Leu Phe Lys Lys Gly Tyr Arg 
            660                 665                 670         


Ser Arg Gln Lys Leu Ala Thr Ala Asp Glu Lys Gln Leu Ala Gly Ile 
        675                 680                 685             


Val Gly Pro Lys Ile Ala Gln Lys Ile Leu Ser Tyr Leu Gly Arg Glu 
    690                 695                 700                 


Thr Asp Ser Asn Gly Tyr Val Glu Pro Glu Thr Leu Glu Asn Lys Lys 
705                 710                 715                 720 


Gln Gln Lys Thr Phe Gln Asp Phe Ile 
                725                 


<210>  41
<211>  730
<212>  PRT
<213>  Methanosarcina mazei

<400>  41

Met Lys Ile Glu Ser Leu Asp Leu Pro Asp Glu Ile Lys Arg Phe Tyr 
1               5                   10                  15      


Glu Asn Ser Gly Ile Leu Glu Leu Tyr Pro Pro Gln Ala Glu Ala Val 
            20                  25                  30          


Glu Lys Gly Leu Leu Glu Gly Lys Asn Leu Leu Ala Ala Ile Pro Thr 
        35                  40                  45              


Ala Ser Gly Lys Thr Leu Leu Ala Glu Leu Ala Met Leu Lys Ser Val 
    50                  55                  60                  


Leu Asn Gly Gly Lys Ala Leu Tyr Ile Val Pro Leu Arg Ala Leu Ala 
65                  70                  75                  80  


Ser Glu Lys Phe Arg Arg Phe Gln Glu Phe Ser Val Leu Gly Met Arg 
                85                  90                  95      


Val Gly Ile Ser Thr Gly Asp Tyr Asp Arg Arg Asp Glu Gly Leu Gly 
            100                 105                 110         


Ile Asn Asp Ile Ile Val Ala Thr Ser Glu Lys Thr Asp Ser Leu Leu 
        115                 120                 125             


Arg Asn Glu Thr Ala Trp Met Gln Glu Ile Ser Val Val Val Ala Asp 
    130                 135                 140                 


Glu Val His Leu Ile Asp Ser Pro Asp Arg Gly Pro Thr Leu Glu Ile 
145                 150                 155                 160 


Thr Leu Ser Lys Leu Arg Arg Met Asn Pro Ser Cys Gln Val Leu Ala 
                165                 170                 175     


Leu Ser Ala Thr Val Gly Asn Ala Asp Glu Leu Ala Ala Trp Leu Asp 
            180                 185                 190         


Ala Glu Leu Val Leu Ser Glu Trp Arg Pro Thr Asp Leu Met Glu Gly 
        195                 200                 205             


Val Phe Tyr Asn Gly Ile Phe Tyr Cys Lys Asp Lys Glu Lys Pro Val 
    210                 215                 220                 


Gly Gln Pro Thr Lys Asp Glu Ala Val Asn Leu Val Leu Asp Thr Ile 
225                 230                 235                 240 


Lys Glu Gly Gly Gln Cys Leu Val Phe Glu Ser Ser Arg Lys Asn Cys 
                245                 250                 255     


Met Gly Phe Ala Lys Lys Ala Val Ser Ala Val Lys Lys Thr Leu Ser 
            260                 265                 270         


Asn Glu Asp Arg Glu Thr Leu Ala Gly Ile Ala Asp Glu Ile Ile Glu 
        275                 280                 285             


Asn Ser Glu Thr Asp Val Ser Ser Val Leu Ala Thr Cys Val Arg Ser 
    290                 295                 300                 


Gly Thr Ala Phe His His Ala Gly Leu Thr Thr Pro Leu Arg Glu Leu 
305                 310                 315                 320 


Val Glu Asn Gly Phe Arg Glu Gly Arg Ile Lys Ile Ile Ser Ser Thr 
                325                 330                 335     


Pro Thr Leu Ala Ala Gly Leu Asn Leu Pro Ala Arg Arg Val Ile Ile 
            340                 345                 350         


Arg Ser Tyr Arg Arg Tyr Ser Ser Asp Ser Gly Met Gln Pro Ile Pro 
        355                 360                 365             


Val Leu Glu Tyr Lys Gln Met Ala Gly Arg Ala Gly Arg Pro Arg Leu 
    370                 375                 380                 


Asp Pro Tyr Gly Glu Ala Val Leu Leu Ala Lys Ser Tyr Glu Glu Phe 
385                 390                 395                 400 


Val Phe Leu Phe Glu Lys Tyr Ile Glu Ala Gly Ala Glu Asp Ile Trp 
                405                 410                 415     


Ser Lys Leu Gly Thr Glu Asn Ala Leu Arg Thr His Ile Leu Ser Thr 
            420                 425                 430         


Ile Ser Asn Gly Phe Ala Arg Thr Arg Glu Glu Leu Met Asp Phe Leu 
        435                 440                 445             


Glu Ala Thr Phe Phe Ala Phe Gln Tyr Ser Asn Phe Gly Leu Ser Ala 
    450                 455                 460                 


Val Val Asp Glu Cys Leu Asp Phe Leu Arg Arg Glu Gly Met Leu Glu 
465                 470                 475                 480 


Lys Asp Pro Asp Ala Leu Val Ser Thr Val Phe Gly Lys Leu Val Ser 
                485                 490                 495     


Arg Leu Tyr Ile Asp Pro Leu Ser Ala Ala Leu Ile Ala Lys Gly Leu 
            500                 505                 510         


Arg Glu Ala Gly Thr Leu Thr Glu Leu Thr Leu Leu His Leu Ile Cys 
        515                 520                 525             


Ser Thr Pro Asp Met Arg Leu Met Tyr Met Arg Ser Gln Asp Tyr Gln 
    530                 535                 540                 


Glu Val Asn Asp Tyr Val Met Ala His Ala Gly Glu Phe Ser Lys Val 
545                 550                 555                 560 


Pro Asn Pro Phe Asn Ile Ala Glu Tyr Glu Trp Phe Leu Gly Glu Val 
                565                 570                 575     


Lys Thr Ser Leu Leu Leu Met Asp Trp Ile His Glu Lys Pro Glu Asn 
            580                 585                 590         


Glu Ile Cys Leu Lys Phe Gly Ile Gly Glu Gly Asp Ile His Ala Thr 
        595                 600                 605             


Ala Asp Ile Ala Glu Trp Ile Met His Val Thr Ala Gln Leu Ala Gly 
    610                 615                 620                 


Leu Leu Asp Leu Lys Gly Ala Lys Glu Ala Ser Glu Leu Glu Lys Arg 
625                 630                 635                 640 


Ile Arg Tyr Gly Ala Ala Pro Glu Leu Met Asp Leu Leu Asp Ile Arg 
                645                 650                 655     


Ser Val Gly Arg Val Arg Ala Arg Lys Leu Tyr Glu Ala Gly Phe Lys 
            660                 665                 670         


Ser Thr Ala Glu Leu Ala Ala Ala Ser Pro Glu His Ile Ala Val Leu 
        675                 680                 685             


Val Gly Pro Lys Ile Thr Glu Arg Ile Phe Lys Gln Ile Gly Arg Arg 
    690                 695                 700                 


Glu Ala Val Ser Glu Phe Ser Asp Ile Glu Pro Leu Glu Lys Gly Ser 
705                 710                 715                 720 


Ser Asp Gly Gln Arg Thr Ile Ser Asp Tyr 
                725                 730 


<210>  42
<211>  693
<212>  PRT
<213>  Methanosaeta thermophila

<400>  42

Met Leu Thr Ile Arg Asp Leu Ile Arg Trp Leu Pro Glu Ser Val Ile 
1               5                   10                  15      


Glu Leu Tyr Glu Ala Leu Gly Ile Asp Glu Leu Tyr Pro Pro Gln Ala 
            20                  25                  30          


Glu Ala Ile Glu Arg Gly Leu Leu Asp Gly Arg Asn Met Ile Ile Ser 
        35                  40                  45              


Val Pro Thr Ala Ala Gly Lys Thr Leu Leu Ala Glu Leu Ala Met Leu 
    50                  55                  60                  


Arg Gly Ala Leu Ser Gly Lys Arg Ser Leu Tyr Ile Val Pro Leu Arg 
65                  70                  75                  80  


Ala Leu Ala Ser Glu Lys Phe Glu Ser Phe Ser Arg Phe Ser Lys Leu 
                85                  90                  95      


Gly Leu Arg Val Gly Ile Ser Thr Gly Asp Phe Glu Lys Arg Asp Glu 
            100                 105                 110         


Arg Leu Gly Arg Asn Asp Ile Ile Ile Ala Thr Ser Glu Lys Ala Asp 
        115                 120                 125             


Ser Leu Ile Arg Asn Gly Ala Ser Trp Val Arg Arg Ile Gly Val Leu 
    130                 135                 140                 


Val Val Asp Glu Ile His Leu Leu Asp Ser Ala Asn Arg Gly Pro Thr 
145                 150                 155                 160 


Leu Glu Met Thr Met Thr Lys Leu Met His Leu Asn Pro Glu Met Gln 
                165                 170                 175     


Val Ile Gly Leu Ser Ala Thr Ile Ala Asn Gly Arg Glu Ile Ala Asp 
            180                 185                 190         


Trp Ile Lys Gly Glu Ile Val Ser Ser Asp Trp Arg Pro Val Arg Leu 
        195                 200                 205             


Arg Glu Gly Val Leu Leu Glu Asp Arg Leu Val Phe Pro Asp Gly Glu 
    210                 215                 220                 


Ile Gln Leu Glu Asn Arg Asn Arg Asp Pro Val Leu Asn Leu Val Leu 
225                 230                 235                 240 


Asp Thr Val Asp Gln Gly Gly Gln Met Leu Ile Phe Glu Ser Thr Arg 
                245                 250                 255     


Arg Asn Ala Glu Ser Met Ala Lys Lys Val Ser Gly Ala Leu Gln Glu 
            260                 265                 270         


Ser Gly Glu Thr Ile Glu Leu Ala Glu Arg Leu Ser Gly Glu Gly Lys 
        275                 280                 285             


Thr Ala Lys Lys Leu Ala Met Cys Leu Arg His Gly Ala Ala Phe His 
    290                 295                 300                 


His Ala Gly Leu Leu Pro Glu Gln Arg Arg Leu Ile Glu Leu Gly Phe 
305                 310                 315                 320 


Arg Gln Asn Val Val Lys Val Ile Ala Cys Thr Pro Thr Leu Ala Ala 
                325                 330                 335     


Gly Leu Asn Leu Pro Ala Arg Arg Val Leu Ile Arg Ser Tyr Lys Arg 
            340                 345                 350         


Tyr Glu Ala Gly Leu Gly Thr Arg Pro Ile Pro Val Met Glu Tyr Arg 
        355                 360                 365             


Gln Met Ala Gly Arg Ala Gly Arg Pro Gly Leu Asp Pro Tyr Gly Glu 
    370                 375                 380                 


Ser Leu Ile Met Ala Arg Ser Glu Ser Glu Leu Gln Lys Leu Met Asp 
385                 390                 395                 400 


His Tyr Val Met Gly Glu Pro Glu Asp Ile Trp Ser Lys Leu Ala Ser 
                405                 410                 415     


Glu Arg Ala Leu Arg Thr His Val Leu Ala Thr Ile Ala Ser Arg Phe 
            420                 425                 430         


Ala Asp Ser Val Asp Ser Leu Ser Arg Leu Met Ala Ser Thr Phe Tyr 
        435                 440                 445             


Ala Arg Gln Gln Asp Pro Ser Tyr Leu Gly Glu Thr Ile Ala Ser Val 
    450                 455                 460                 


Leu Glu Phe Leu Val Arg Ser Asp Met Ile Asp Lys Asp Leu Thr Pro 
465                 470                 475                 480 


Thr Pro Leu Gly Ala Leu Val Ser Arg Leu Tyr Ile Asp Pro Leu Ser 
                485                 490                 495     


Ala Met Val Met Ile Gln Glu Ile Arg Gly Ile Arg Arg Pro Thr Val 
            500                 505                 510         


Leu Thr Leu Leu His Val Ile Thr Met Thr Pro Asp Met Glu Leu Leu 
        515                 520                 525             


Phe Val Gln Gln Ser Asp Asn Trp Leu Glu Asp Phe Ile Ser Glu His 
    530                 535                 540                 


Ser Ser Glu Leu Gly Asn Glu Lys Asn Phe Asp Trp Leu Leu Arg Glu 
545                 550                 555                 560 


Val Lys Thr Ala Ser Met Leu Met Asp Trp Ile Asn Glu Val His Glu 
                565                 570                 575     


Asp Arg Ile Glu Asp Arg Tyr Ser Ile Ser Pro Gly Asp Leu Val Arg 
            580                 585                 590         


Ile Ala Glu Thr Ala Glu Trp Leu Met Ser Ala Leu His Arg Ile Ser 
        595                 600                 605             


Lys His Met Asp Leu Gly Val Thr Tyr Leu Ala Glu Arg Leu Ala Leu 
    610                 615                 620                 


Arg Ile His Tyr Gly Ala Gly Asp Glu Leu Leu Gln Leu Leu Glu Leu 
625                 630                 635                 640 


Lys Gly Ile Gly Arg Val Arg Ala Arg Lys Leu Tyr Gln Ala Gly Tyr 
                645                 650                 655     


Arg Ser Leu Glu Asp Leu Lys Ala Ala Asp Lys Ser Thr Leu Ser Glu 
            660                 665                 670         


Ile Leu Gly Pro Lys Ile Ala Glu Gly Val Ile Ser Gln Leu Lys Glu 
        675                 680                 685             


Pro Gly Val Ser Ala 
    690             


<210>  43
<211>  739
<212>  PRT
<213>  Methanosalsum zhilinae

<400>  43

Met Asn Ile Asn Asn Leu Asn Leu Pro Glu Lys Val Lys Lys Tyr Tyr 
1               5                   10                  15      


Thr Asp Thr Gly Ile Val Asp Leu Tyr Pro Pro Gln Arg Glu Ala Val 
            20                  25                  30          


Asp Lys Gly Leu Leu Asp Gly Glu Asn Ile Val Ala Ala Ile Pro Thr 
        35                  40                  45              


Ala Ser Gly Lys Thr Leu Leu Ala Glu Leu Cys Met Leu Lys Ser Ile 
    50                  55                  60                  


Gly Met Gly Gly Lys Cys Leu Tyr Ile Val Pro Leu Lys Ala Leu Ala 
65                  70                  75                  80  


Ser Glu Lys Tyr Ser Arg Phe Arg Glu Phe Glu Ser Leu Gly Ile Lys 
                85                  90                  95      


Val Gly Ile Ala Thr Gly Asp Leu Asp Ser Arg Glu Glu Trp Leu Gly 
            100                 105                 110         


Lys Asn Asp Ile Ile Ile Ala Thr Ser Glu Lys Val Asp Ser Leu Leu 
        115                 120                 125             


Arg Asn Glu Ser Ser Trp Met Lys Glu Ile Asn Thr Val Val Ala Asp 
    130                 135                 140                 


Glu Val His Leu Leu Asn Ser Val Asn Arg Gly Pro Thr Leu Glu Ile 
145                 150                 155                 160 


Thr Leu Ala Lys Leu Ile His Leu Asn Pro Gly Ser Gln Ile Ile Ala 
                165                 170                 175     


Leu Ser Ala Thr Ile Gly Asn Pro Glu Asp Ile Ala Gly Trp Leu Gly 
            180                 185                 190         


Ala Arg Leu Val Val Ser Glu Trp Arg Pro Thr Asp Leu Tyr Glu Gly 
        195                 200                 205             


Ile Leu Leu Asp Gly Leu Leu His Ile Gly Asn Ile Lys Lys Asp Ile 
    210                 215                 220                 


Gln Asp Glu Ser Arg Asp Asp Ala Val Asn Leu Val Ile Asp Thr Val 
225                 230                 235                 240 


Lys Asp Lys Gly Gln Cys Leu Val Phe Glu Ser Ser Arg Arg Asn Cys 
                245                 250                 255     


Met Gly Phe Ala Lys Lys Ala Gly Lys Trp Val Ser Lys Ile Leu Asp 
            260                 265                 270         


Glu His Asp Thr Ile Gln Leu Lys Ser Leu Ser Gln Glu Ile Gly Glu 
        275                 280                 285             


Ala Gly Glu Thr Glu Ile Ala Asp Val Leu Ser Arg Cys Val Arg Gln 
    290                 295                 300                 


Gly Val Ala Phe His His Ala Gly Leu Asn Ser Glu His Arg Arg Met 
305                 310                 315                 320 


Val Glu Glu Gly Phe Arg Lys Asn Leu Ile Lys Met Ile Ser Ser Thr 
                325                 330                 335     


Pro Thr Leu Ala Ala Gly Leu Asn Leu Pro Ala Arg Arg Val Ile Ile 
            340                 345                 350         


Arg Ser Tyr Lys Arg Tyr Asp Pro Asn Phe Gly Met Lys Pro Ile Pro 
        355                 360                 365             


Val Leu Glu Tyr Lys Gln Met Ala Gly Arg Ala Gly Arg Pro His Leu 
    370                 375                 380                 


Asp Pro Tyr Gly Glu Ser Val Leu Ile Ala Arg Ser Tyr Asp Glu Phe 
385                 390                 395                 400 


Met Asp Ile Met Glu Asn Tyr Val Asn Ala Asp Pro Glu Asp Ile Trp 
                405                 410                 415     


Ser Lys Leu Gly Thr Glu Asn Ala Leu Arg Thr His Val Leu Ser Thr 
            420                 425                 430         


Ile Val Asn Gly Phe Ala Tyr Thr Tyr Arg Gly Leu Met Asp Phe Val 
        435                 440                 445             


Lys Met Thr Phe Phe Ala Tyr Gln Lys Glu Ala Ser Asp Leu His Asp 
    450                 455                 460                 


Val Ile Glu Glu Cys Val Arg Phe Leu Ile Asp Asn Glu Met Ile Ile 
465                 470                 475                 480 


Ser Asp Ser Asn Asp Ile Leu Pro Glu Ser Ala Phe Arg Ser Thr Ala 
                485                 490                 495     


Thr Gly Lys Leu Ile Ser Met Leu Tyr Ile Asp Pro Leu Ser Gly Ser 
            500                 505                 510         


Leu Ile Met Asp Gly Ile Arg Lys Ala Asp Tyr Phe Glu Asp Ile Thr 
        515                 520                 525             


Met Met His Leu Ile Cys Ser Thr Pro Asp Met Lys Asn Leu Tyr Met 
    530                 535                 540                 


Arg Ser Ser Asp Tyr Glu Asn Val Asn Met Tyr Val Leu Gln Asn Lys 
545                 550                 555                 560 


Asp Lys Phe Ile Ser Met Pro Ser Pro Phe Lys Met Ile Glu Tyr Glu 
                565                 570                 575     


Trp Phe Leu Gly Glu Val Lys Thr Ala Leu Leu Leu Leu Asp Trp Ile 
            580                 585                 590         


Asn Glu Val Pro Ala Asp Asp Ile Cys Lys Lys Tyr Gly Ile Gly Glu 
        595                 600                 605             


Gly Asp Ile Arg Met Phe Ser Glu Thr Ala Val Trp Leu Met His Ala 
    610                 615                 620                 


Thr Ser Arg Leu Ser Gly Leu Leu Lys Val Ser Glu Ala Ser Glu Lys 
625                 630                 635                 640 


Ser Lys Glu Leu Glu Lys Arg Leu Ser Tyr Gly Ile Asn Ser Glu Leu 
                645                 650                 655     


Val Asn Ile Val Ala Leu Lys Gly Ile Gly Arg Val Arg Ala Arg Lys 
            660                 665                 670         


Ile Tyr Glu Asn Gly Tyr Arg Ser Ile Asp Asp Leu Lys Lys Ala Asp 
        675                 680                 685             


Pro Leu Lys Leu Ser Lys Ile Val Gly Ser Lys Ile Ser Gln Lys Ile 
    690                 695                 700                 


Leu Lys Gln Leu Asp Ile Asp Val Asp Ile Ser Glu Ile Lys Glu Lys 
705                 710                 715                 720 


Asp Ser Asp Thr Val Pro Glu Pro Glu Ser Ser Gln Lys Thr Ile Ser 
                725                 730                 735     


Asp Phe Thr 
            


<210>  44
<211>  733
<212>  PRT
<213>  Methanohalobium evestigatum

<400>  44

Met Glu Thr Gly Lys Leu Glu Leu Pro Glu Tyr Val Ile Gln Phe Tyr 
1               5                   10                  15      


Leu Asp Thr Gly Ile Glu Lys Leu Tyr Pro Pro Gln Ala Glu Ala Val 
            20                  25                  30          


Glu Lys Gly Leu Leu Asp Asn Lys Asn Leu Leu Ala Ala Ile Pro Thr 
        35                  40                  45              


Ala Ser Gly Lys Thr Leu Ile Ser Glu Leu Ala Met Leu Lys Ser Ile 
    50                  55                  60                  


Ser Asn Gly Gly Lys Cys Leu Tyr Ile Val Pro Leu Arg Ala Leu Ala 
65                  70                  75                  80  


Ser Glu Lys Phe Glu Arg Phe Lys Gln Phe Ser Ser Ile Gly Val Asn 
                85                  90                  95      


Ile Gly Ile Ser Thr Gly Asp Phe Asp Ser Thr Asp Glu Trp Leu Gly 
            100                 105                 110         


Ser Asn Asp Ile Ile Val Ala Thr Ser Glu Lys Ala Asp Ser Leu Leu 
        115                 120                 125             


Arg Asn Glu Thr Ser Trp Met Lys Asp Ile Thr Thr Ile Val Val Asp 
    130                 135                 140                 


Glu Ile His Leu Leu Asp Ser Ala Asp Arg Gly Pro Thr Leu Glu Ile 
145                 150                 155                 160 


Thr Ile Ala Lys Leu Leu Arg Leu Asn Pro Asn Ser Gln Ile Ile Gly 
                165                 170                 175     


Leu Ser Ala Thr Ile Gly Asn Ala Glu Glu Ile Ala Gly Trp Leu Asp 
            180                 185                 190         


Ala Glu Leu Val Gln Ser Gln Trp Arg Pro Ile Glu Leu Tyr Glu Gly 
        195                 200                 205             


Val Phe Leu Glu Asp Asn Ile Asn Phe Lys Gln Ser Gln Lys Pro Ile 
    210                 215                 220                 


Lys Asn Ile Val Lys Asp Thr Ala Val Asn Leu Val Leu Asp Thr Ile 
225                 230                 235                 240 


Asp Glu Asn Gly Gln Cys Leu Val Phe Glu Ser Ser Arg Arg Asn Cys 
                245                 250                 255     


Ala Gly Phe Ala Lys Lys Ala Lys Ser Lys Val Gly Lys Ser Leu Asp 
            260                 265                 270         


Lys Gly Leu Leu Ala Glu Leu Asn Asn Ile Ala Glu Glu Val Leu Glu 
        275                 280                 285             


Thr Ser Asp Thr Glu Thr Thr Lys Glu Leu Ala Ser Cys Ile Lys Arg 
    290                 295                 300                 


Gly Thr Ala Phe His His Ala Gly Leu Asn Ser Ala Gln Arg Lys Ile 
305                 310                 315                 320 


Val Glu Asp Asn Phe Arg Asn Asn Lys Ile Lys Val Ile Ser Ser Thr 
                325                 330                 335     


Pro Thr Leu Ala Ala Gly Leu Asn Leu Pro Ala Arg Arg Val Ile Val 
            340                 345                 350         


Arg Asn Tyr Lys Arg Tyr Asp Pro Asn Phe Gly Met Gln Pro Ile Pro 
        355                 360                 365             


Val Leu Asp Tyr Lys Gln Met Ala Gly Arg Ala Gly Arg Pro Ser Leu 
    370                 375                 380                 


Asp Pro Tyr Gly Glu Ser Val Leu Ile Ser His Thr Tyr Asn Glu Phe 
385                 390                 395                 400 


Thr Asp Leu Leu Asp Arg Tyr Ile Asp Ala Glu Pro Glu Asp Ile Leu 
                405                 410                 415     


Ser Lys Leu Gly Thr Glu Asn Ala Leu Arg Thr His Val Leu Ser Thr 
            420                 425                 430         


Ile Val Asn Gly Phe Ala Thr Thr Arg Gln Gly Met Val Asp Phe Met 
        435                 440                 445             


Gly Ser Ser Phe Phe Ala Tyr Gln Gln Gln Lys Trp Ser Leu Ile Asp 
    450                 455                 460                 


Val Val Asp Asp Cys Ile Glu Phe Leu Gln Asp Asn Glu Met Ile Lys 
465                 470                 475                 480 


Asp Asp Gly Glu Arg Leu Tyr Ala Thr Arg Leu Gly Gln Val Ile Ser 
                485                 490                 495     


Thr Leu Tyr Ile Asp Pro Leu Ser Gly Ala Ile Ile Ile Asp Lys Leu 
            500                 505                 510         


Lys Lys Ala Asp Lys Val Thr Asp Met Thr Met Leu His Ile Ile Cys 
        515                 520                 525             


Ser Thr Pro Asp Met Arg Gln Leu Tyr Leu Arg Ser Lys Glu Tyr Glu 
    530                 535                 540                 


Lys Ile Asn Glu Tyr Val Met Thr His Ser Asp Glu Phe Val Glu Val 
545                 550                 555                 560 


Pro Asn Pro Phe Lys Ser Ile Glu Tyr Glu Trp Phe Leu Gly Glu Val 
                565                 570                 575     


Lys Thr Ala Leu Leu Ile Asn Glu Trp Ile Asp Glu Lys Thr Leu Asp 
            580                 585                 590         


Asp Ile Thr Ala Glu Phe Gly Val Gly Glu Gly Asp Ile Asn Ala Leu 
        595                 600                 605             


Ser Asp Ile Ser Glu Trp Leu Met His Ser Ala Val Asn Leu Ala Asn 
    610                 615                 620                 


Leu Thr Asp Leu Asp Ala Asp Lys Ala Gln Glu Leu Glu Lys Arg Ile 
625                 630                 635                 640 


His His Gly Val Asn Lys Asp Leu Ile Gln Leu Val Ser Ile Ser Asn 
                645                 650                 655     


Ile Gly Arg Val Arg Ala Arg Lys Leu Tyr Glu Ala Gly Ile Gln Ser 
            660                 665                 670         


Val Ser Asp Ile Lys Asn Thr Lys Leu His Ile Leu Ser Asn Tyr Leu 
        675                 680                 685             


Gly Arg Lys Thr Ala Tyr Lys Val Leu Glu Gln Leu Gly Val Glu Pro 
    690                 695                 700                 


Glu Asp Asn Gln Gln Ile Asp Glu Glu Pro Glu Ser Ile Lys Ser Tyr 
705                 710                 715                 720 


Ser Gly Asn Asp Gln Gly Gln Lys Thr Phe Asn Asp Phe 
                725                 730             


<210>  45
<211>  747
<212>  PRT
<213>  Methanococcus maripaludis

<400>  45

Met His Val Leu Asp Leu Leu Lys Glu Asn Lys Ile Thr Glu Leu Arg 
1               5                   10                  15      


Pro Pro Gln Lys Lys Val Ile Asp Glu Gly Leu Phe Asp Lys Thr Lys 
            20                  25                  30          


Asn Phe Leu Ile Cys Ile Pro Thr Ala Ser Gly Lys Thr Leu Ile Gly 
        35                  40                  45              


Glu Met Ala Leu Leu Asn His Ile Leu Asp Glu Asn Lys Asn Leu Thr 
    50                  55                  60                  


Gly Lys Lys Gly Leu Phe Ile Val Pro Leu Lys Ala Leu Ala Asn Glu 
65                  70                  75                  80  


Lys Phe Asp Glu Phe Arg Glu Lys Tyr Glu Lys Tyr Gly Ile Lys Val 
                85                  90                  95      


Gly Leu Ser Ile Gly Asp Phe Asp Thr Lys Glu Asn Leu Ser Lys Phe 
            100                 105                 110         


His Ile Ile Ile Thr Thr Ser Glu Lys Leu Asp Ser Leu Met Arg His 
        115                 120                 125             


Asn Val Glu Trp Ile Asn Asp Val Ser Leu Ala Val Ile Asp Glu Ile 
    130                 135                 140                 


His Leu Ile Gly Asp Asn Glu Arg Gly Gly Thr Leu Glu Val Ile Leu 
145                 150                 155                 160 


Thr Lys Leu Lys Asn Leu Asn Ala Gln Ile Val Gly Leu Ser Ala Thr 
                165                 170                 175     


Ile Gly Asn Pro Glu Glu Leu Ser Asn Trp Leu Asn Ala Lys Leu Ile 
            180                 185                 190         


Val Asp Gly Trp Arg Pro Val Glu Leu Lys Lys Gly Ile Tyr Phe Glu 
        195                 200                 205             


Asn Glu Leu Glu Phe Leu Lys Asn Pro Ala Lys Lys Ile Lys Gln Val 
    210                 215                 220                 


Ser Arg Asn Asn Leu Thr Asp Leu Ile Val Asp Ser Val Glu Glu Lys 
225                 230                 235                 240 


Gly Ser Cys Leu Ile Phe Cys Asn Ser Lys Arg Asn Ala Val Gly Glu 
                245                 250                 255     


Ala Lys Lys His Asn Leu Ala Lys Tyr Leu Thr Arg Thr Glu Gln His 
            260                 265                 270         


Glu Leu Asn Lys Leu Ser Glu Glu Ile Leu Ser Ile Leu Asp Arg Pro 
        275                 280                 285             


Val Glu Thr Cys Lys Ala Leu Ser Lys Cys Ile Gln Asn Gly Val Ala 
    290                 295                 300                 


Phe His His Ala Gly Leu Thr Tyr Lys His Arg Lys Ile Val Glu Asp 
305                 310                 315                 320 


Gly Phe Arg Asn Arg Leu Ile Lys Val Ile Cys Cys Thr Pro Thr Leu 
                325                 330                 335     


Ser Ala Gly Leu Asn Leu Pro Cys Arg Arg Ala Ile Val Arg Asp Ile 
            340                 345                 350         


Lys Arg Tyr Ser Gln Asn Gly Leu Val Asp Ile Pro Arg Met Glu Ile 
        355                 360                 365             


Gln Gln Cys Ile Gly Arg Ala Gly Arg Pro Gly Leu Asp Pro Tyr Gly 
    370                 375                 380                 


Glu Gly Ile Ile Tyr Ile Lys Asn Glu Arg Asp Ala Glu Lys Ala Tyr 
385                 390                 395                 400 


Glu Ile Leu Thr Gly Ser Val Glu Asn Ile Tyr Ser Lys Leu Ala Asn 
                405                 410                 415     


Gln Lys Val Leu Arg Ile His Ile Leu Gly Leu Ile Ser Thr Gly Glu 
            420                 425                 430         


Ile Lys Asp Gly Gln Asn Leu Val Asn Phe Met Lys Asn Thr Phe Tyr 
        435                 440                 445             


Ala His Gln Phe Gly Asn Ile Gly Ala Val Leu Leu Asn Val Ser Glu 
    450                 455                 460                 


Val Val Glu Phe Leu Glu Lys Asn Lys Phe Leu Glu Thr Thr Ile His 
465                 470                 475                 480 


Lys Lys Thr Glu Asn Lys Val Arg Glu Leu Ser Phe Asp Ser Ser Asn 
                485                 490                 495     


Asn Leu Val Leu Asp Ser Lys Glu Thr Ser Phe Asp Leu Thr Asn Pro 
            500                 505                 510         


Asn Ser Asn Ile Glu Phe Arg Ser Thr Lys Leu Gly Lys Arg Ile Ser 
        515                 520                 525             


Glu Leu Tyr Ile Asp Pro Met Ser Ser Glu Ile Ile Ile Glu Glu Leu 
    530                 535                 540                 


His Glu Leu Lys Lys Lys Cys Asp Gln Leu Asp Arg Ser Lys Ile Asp 
545                 550                 555                 560 


Gln Tyr Leu Phe Tyr Leu Ile Ser Lys Thr Asn Glu Met Arg Pro Leu 
                565                 570                 575     


Leu Arg Ile Arg Pro Asn Glu Glu Leu Asp Leu Ile Leu Glu Met Asp 
            580                 585                 590         


Lys Met Gly Leu Lys Asp Tyr Ser Ile Glu Asn Ile Glu Ala Phe Lys 
        595                 600                 605             


Asn Ser Lys Met Phe Cys Asp Trp Val Ser Glu Ile Pro Glu Glu Ile 
    610                 615                 620                 


Ile Leu Glu Lys Tyr Gly Val Glu Pro Gly Ile Leu Arg Tyr Lys Val 
625                 630                 635                 640 


Glu Gln Ala Lys Trp Met Ile Tyr Ser Thr Lys Glu Ile Ala Lys Leu 
                645                 650                 655     


Ile His Leu Asp Asn Ser Glu Ile Tyr Lys Ser Leu Leu Lys Met Glu 
            660                 665                 670         


Val Arg Ile Glu Tyr Gly Ala Lys Glu Glu Leu Ile Glu Leu Leu Asn 
        675                 680                 685             


Val Lys Asn Val Gly Arg Ile Arg Ser Arg Lys Leu Tyr Asp Ala Gly 
    690                 695                 700                 


Ile Arg Ser Lys Ile Glu Ile Asn Lys Asn Pro Glu Lys Ile Leu Glu 
705                 710                 715                 720 


Leu Phe Gly Glu Lys Ile Gly Lys Lys Ile Leu Gly Glu His Gly Met 
                725                 730                 735     


Lys Tyr Gly Gln Gln Thr Leu Leu Asn Phe Asn 
            740                 745         


<210>  46
<211>  799
<212>  PRT
<213>  Natrialba magadii

<400>  46

Met Asn Val Glu Glu Leu Ser Gly Leu Pro Pro Gly Ala Arg Ser His 
1               5                   10                  15      


Phe Gln Glu Gln Gly Ile Glu Glu Leu Tyr Pro Pro Gln Ala Glu Ala 
            20                  25                  30          


Val Glu Ala Gly Ala Thr Glu Gly Glu Asn Leu Val Ala Ala Val Pro 
        35                  40                  45              


Thr Ala Ser Gly Lys Thr Met Ile Ala Ala Leu Ser Met Leu Ser Ala 
    50                  55                  60                  


Val Gln Arg Gly Gly Lys Ala Leu Tyr Ile Val Pro Leu Arg Ala Leu 
65                  70                  75                  80  


Ala Ser Glu Lys Lys Ala Glu Phe Asp Ala Tyr Glu Glu Phe Gly Val 
                85                  90                  95      


Thr Thr Gly Val Ala Thr Gly Asn Tyr Glu Ser Thr Ser Glu Trp Leu 
            100                 105                 110         


Ala Thr Lys Asp Ile Ile Val Ala Thr Ser Glu Lys Val Asp Ser Leu 
        115                 120                 125             


Val Arg Asn Gly Ala Asp Trp Leu Ser Asp Leu Thr Cys Val Val Ser 
    130                 135                 140                 


Asp Glu Val His Leu Ile Asp Asp Arg Asn Arg Gly Pro Thr Leu Glu 
145                 150                 155                 160 


Val Thr Leu Ala Lys Leu Arg Arg Leu Asn Pro Gln Leu Gln Val Val 
                165                 170                 175     


Ala Leu Ser Ala Thr Val Gly Asn Ala Asp Glu Leu Ala Asp Trp Leu 
            180                 185                 190         


Asp Ala Glu Leu Val Asp Thr Asp Trp Arg Pro Ile Asp Leu Gln Met 
        195                 200                 205             


Gly Val His Tyr Gly Asn Ala Leu Asn Phe Asp Asp Gly Glu Thr Arg 
    210                 215                 220                 


Glu Val Pro Val Glu Ala Gly Glu Lys Gln Glu Ala Ala Leu Val Arg 
225                 230                 235                 240 


Asp Ile Leu Gln Glu Gly Gly Ser Ser Leu Val Phe Val Asn Ser Arg 
                245                 250                 255     


Arg Asn Ala Glu Ala Ala Ala Arg Arg Leu Gly Gln Val Ser Ser Arg 
            260                 265                 270         


Glu Leu Thr Ala Gly Glu Gln Asn Asp Leu Ala Ala Leu Ala Thr Glu 
        275                 280                 285             


Ile Arg Glu Asp Ser Asp Thr Glu Thr Ser Gln Asp Leu Ala Asp Cys 
    290                 295                 300                 


Val Glu Arg Gly Ala Ala Phe His His Ala Gly Leu Ser Ser Thr Gln 
305                 310                 315                 320 


Arg Ser Leu Val Glu Asp Ala Phe Arg Asp Arg Leu Leu Lys Val Ile 
                325                 330                 335     


Ser Ala Thr Pro Thr Leu Ala Ala Gly Val Asn Thr Pro Ala Arg Arg 
            340                 345                 350         


Val Ile Val Arg Asp Trp Arg Arg Phe Asp Pro Ser Ala Gly Gly Met 
        355                 360                 365             


Ala Pro Leu Asp Val Leu Glu Val His Gln Met Met Gly Arg Ala Gly 
    370                 375                 380                 


Arg Pro Gly Leu Asp Pro Tyr Gly Glu Ala Val Leu Leu Ala Lys Ser 
385                 390                 395                 400 


His Asp Glu Ser Gln Glu Leu Phe Asp Arg Tyr Val Trp Ala Asp Pro 
                405                 410                 415     


Glu Pro Val Arg Ser Lys Leu Ala Ala Glu Pro Ala Leu Arg Thr His 
            420                 425                 430         


Val Leu Ala Thr Ile Ala Ser Gly Phe Ala Arg Thr Arg Glu Gly Leu 
        435                 440                 445             


Leu Glu Phe Leu Glu Ala Thr Leu Tyr Ala Ser Gln Ser Ser Glu Gly 
    450                 455                 460                 


Gly Arg Leu Glu Arg Val Thr Asp Asp Val Leu Ser Tyr Leu Glu Arg 
465                 470                 475                 480 


Asn Asp Phe Ile Glu Arg Ser Gly Gly Pro Glu Asp Thr Leu Asn Ser 
                485                 490                 495     


Glu Ala Asp Ala Ala Ser Ala Phe Thr Ser Ala Ala Asp Leu Ala Asp 
            500                 505                 510         


Ser Asp Gly Gly Asp Ser Gly Gly Thr Thr Gly Gln Glu Glu Asp Leu 
        515                 520                 525             


Glu Ala Thr Ser Leu Gly His Thr Val Ser Arg Leu Tyr Leu Asp Pro 
    530                 535                 540                 


Met Ser Ala Ala Glu Ile Val His Gly Leu Glu Asp Ala Asp Glu Arg 
545                 550                 555                 560 


Pro Thr Ala Leu Gly Leu Tyr Gln Leu Val Ser Arg Thr Pro Asp Met 
                565                 570                 575     


Tyr Glu Leu Tyr Leu Arg Ser Gly Glu Asp Glu Lys Phe Gly Glu Leu 
            580                 585                 590         


Tyr Tyr Glu Arg Glu Arg Glu Leu Leu Gly Asp Ala Pro Ser Glu Phe 
        595                 600                 605             


Glu Glu Glu Arg Phe Glu Asp Trp Leu Ala Ala Leu Lys Thr Gly Lys 
    610                 615                 620                 


Leu Leu Glu Asp Trp Ala Thr Glu Asp Asp Glu Glu Gln Ile Thr Glu 
625                 630                 635                 640 


Arg Tyr Lys Ile Gly Pro Gly Asp Leu Arg Gly Lys Val Asp Thr Ala 
                645                 650                 655     


Glu Trp Leu Leu Gly Ala Ala Glu Ser Leu Ala Ser Glu Ile Asp Ser 
            660                 665                 670         


Glu Trp Ala Val Ala Val Arg Glu Ala Arg Ala Arg Val Glu His Gly 
        675                 680                 685             


Val Gly Glu Glu Leu Leu Glu Leu Val Ser Val Ser Gly Ile Gly Arg 
    690                 695                 700                 


Lys Arg Ala Arg Arg Leu Tyr Ala Ala Gly Ile Glu Glu Pro Ala Ala 
705                 710                 715                 720 


Leu Arg Ser Ala Asp Lys Gly Val Ile Leu His Val Leu Lys Gly Glu 
                725                 730                 735     


Lys Thr Ala Glu Asn Ile Leu Glu Asn Ala Gly Arg Glu Glu Pro Ser 
            740                 745                 750         


Met Asp Gly Val Glu Pro Ile Pro Val Glu Gly Gly Ser Gly Ser Gly 
        755                 760                 765             


Ser Ser Asn Ser Ser Gly Ser Ser Glu Pro Asn Ala Asp Ala Asn Ala 
    770                 775                 780                 


Thr Glu Asp Asp Ala Asp Asp Asn Gln Ser Ser Leu Gly Asp Phe 
785                 790                 795                 


<210>  47
<211>  723
<212>  PRT
<213>  Methanoregula boonei

<400>  47

Met Gln Ile Gln Asp Leu Ala Ile Pro Glu Pro Leu Arg Gln Gln Tyr 
1               5                   10                  15      


Leu Gly Leu Gly Ile Arg Glu Leu Tyr Pro Pro Gln Ala Ala Cys Val 
            20                  25                  30          


Glu Arg Gly Leu Leu Asp Gly Lys Asn Leu Leu Val Ala Ile Pro Thr 
        35                  40                  45              


Ala Ser Gly Lys Thr Leu Ile Ala Glu Met Ala Met His Arg His Ile 
    50                  55                  60                  


Ala Asn Gly Gly Lys Cys Leu Tyr Ile Val Pro Leu Lys Ala Leu Ala 
65                  70                  75                  80  


Ser Glu Lys Tyr Glu Glu Phe Gly Asn Lys Gly Val Lys Val Gly Leu 
                85                  90                  95      


Ser Thr Gly Asp Leu Asp Arg Arg Asp Asp Ala Leu Gly Lys Asn Asp 
            100                 105                 110         


Ile Ile Val Ala Thr Ser Glu Lys Val Asp Ser Leu Leu Arg Asn Gly 
        115                 120                 125             


Ala Arg Trp Ile Pro Asp Ile Thr Leu Val Val Ile Asp Glu Ile His 
    130                 135                 140                 


Leu Ile Asp Ser Pro Asp Arg Gly Pro Thr Leu Glu Met Val Ile Ala 
145                 150                 155                 160 


Lys Met Arg Ser Lys Asn Pro Gly Met Gln Leu Ile Gly Leu Ser Ala 
                165                 170                 175     


Thr Ile Gly Asn Pro Lys Val Leu Ala Gly Trp Leu Asp Ala Glu Leu 
            180                 185                 190         


Val Thr Ser Ser Trp Arg Pro Val Asp Leu Arg Gln Gly Val Phe Tyr 
        195                 200                 205             


Asp Asn Arg Ile Gln Phe Ala Glu Arg Met Arg Pro Val Lys Gln Val 
    210                 215                 220                 


Ser Lys Asn Tyr Asp Asp Leu Asn Leu Cys Leu Asp Thr Ile Ala Glu 
225                 230                 235                 240 


Gly Gly Gln Cys Leu Val Phe Val Ser Ser Arg Arg Asn Ala Glu Ala 
                245                 250                 255     


Phe Ala Lys Arg Ala Ala Gly Ala Ile Lys Ser Glu Asp Ala Ala Leu 
            260                 265                 270         


Ala Ala Cys Ala Glu Arg Leu Leu Glu Gly Thr Pro Thr Glu Met Val 
        275                 280                 285             


Lys Thr Leu Ala Ala Cys Val Ala Lys Gly Ala Ala Phe His His Ala 
    290                 295                 300                 


Gly Leu Ser Arg Lys Glu Arg Ser Ile Val Glu Glu Ala Phe Arg Lys 
305                 310                 315                 320 


Asn Leu Leu Lys Cys Ile Ser Ser Thr Pro Thr Leu Ala Ala Gly Leu 
                325                 330                 335     


Asn Leu Pro Ala Arg Arg Val Ile Ile Arg Asp Tyr Leu Arg Phe Ser 
            340                 345                 350         


Ala Gly Glu Gly Met Gln Pro Ile Pro Val Ser Glu Tyr Arg Gln Met 
        355                 360                 365             


Ala Gly Arg Ala Gly Arg Pro Arg Leu Asp Pro Tyr Gly Glu Ala Val 
    370                 375                 380                 


Leu Ile Ala Lys Glu Ala Glu Gln Val Pro Glu Leu Phe Glu Val Tyr 
385                 390                 395                 400 


Ile Glu Ala Glu Ala Glu Asp Val His Ser Arg Ile Ala Glu Pro Thr 
                405                 410                 415     


Ala Leu Tyr Thr His Val Leu Ser Leu Val Ala Ser Gly Phe Ala Gly 
            420                 425                 430         


Thr Arg Gly Glu Leu Thr Glu Phe Met Asn Arg Ser Phe Tyr Val His 
        435                 440                 445             


Glu His Lys Gln Gly Arg Leu Ile His Arg Ala Ile Asp Glu Ala Leu 
    450                 455                 460                 


Gln Phe Leu Ile Thr Ala Glu Met Val Val Glu Val Gly Glu His Ile 
465                 470                 475                 480 


Gly Ala Thr Glu Leu Gly Thr Leu Val Ser Arg Met Tyr Ile Asp Pro 
                485                 490                 495     


Arg Ser Ala Phe Ala Ile Val Thr Thr Leu Arg Glu Gln Glu Lys Tyr 
            500                 505                 510         


Ala Asp Leu Gly Leu Ile Gln Leu Ile Cys Thr Thr Pro Asp Met Pro 
        515                 520                 525             


Thr Leu Tyr Ala Lys Asn Ala Asp Leu Pro Ala Leu Ser Arg Met Leu 
    530                 535                 540                 


Glu Val Arg Gly Ala Asp Ile Trp Leu Pro Pro Pro Leu Asp Asp Asp 
545                 550                 555                 560 


Ala Ala Glu Thr Tyr Tyr Arg Ala Val Lys Thr Ala Met Leu Leu Ser 
                565                 570                 575     


Asp Trp Thr Asp Glu Leu Ser Glu Glu Lys Ile Cys Glu Arg Tyr Gly 
            580                 585                 590         


Val Gly Pro Gly Asp Val Phe Gly Met Val Glu Asn Ile Asn Trp Leu 
        595                 600                 605             


Leu His Ala Thr Ser Gln Leu Ala Arg Met Phe Val Pro Lys Phe Tyr 
    610                 615                 620                 


Gly Gln Ile Ala Asp Cys Glu Ile Cys Met Lys Asn Gly Ile Arg Arg 
625                 630                 635                 640 


Glu Leu Leu Pro Leu Val Arg Leu Arg Gly Ile Gly Arg Val Arg Ala 
                645                 650                 655     


Arg Arg Leu Phe Asn Asn Gly Ile Thr Ser Pro Glu Glu Leu Ser Arg 
            660                 665                 670         


His Lys Lys Glu Asp Leu Val Lys Ile Leu Gly Ser Gly Ile Ala Glu 
        675                 680                 685             


Gln Val Leu Glu Gln Leu His Pro Ser Lys Asp Thr Gly Lys Lys Glu 
    690                 695                 700                 


Pro Pro Ser Gly Asp Lys Asn Thr Asn Pro Gly Gln Ser Thr Leu Phe 
705                 710                 715                 720 


His Phe Gly 
            


<210>  48
<211>  681
<212>  PRT
<213>  Ferroplasma acidarmanus

<400>  48

Met Lys Leu Ser Glu Ile Thr Pro Ser Glu Phe Leu Lys Val Thr Asp 
1               5                   10                  15      


Asn Asn Asp Phe Thr Leu Tyr Glu His Gln Glu Glu Ala Val Ala Lys 
            20                  25                  30          


Leu Arg Glu Asn Lys Asn Val Ile Val Ser Val Pro Thr Ala Ser Gly 
        35                  40                  45              


Lys Thr Leu Ile Gly Tyr Ile Ser Ile Tyr Asp Thr Tyr Leu Lys Gly 
    50                  55                  60                  


Lys Lys Ser Met Tyr Ile Val Pro Leu Arg Ser Leu Ala Met Glu Lys 
65                  70                  75                  80  


Phe Ser Glu Leu Leu Ser Leu Arg Asn Leu Gly Val Lys Val Thr Met 
                85                  90                  95      


Ser Ile Gly Asp Tyr Asp Val Pro Pro Ser Phe Val Lys Asn Tyr Asp 
            100                 105                 110         


Val Ile Ile Ala Thr Ser Glu Arg Ala Asp Ser Met Leu His Arg Asp 
        115                 120                 125             


Pro Asp Ile Leu Asn Tyr Phe Gly Leu Val Ile Ile Asp Glu Ile His 
    130                 135                 140                 


Met Ile Ser Asp Pro Ser Arg Gly Pro Arg Leu Glu Thr Val Ile Ser 
145                 150                 155                 160 


Ser Leu Leu Tyr Leu Asn Pro Glu Ile Leu Leu Leu Gly Leu Ser Ala 
                165                 170                 175     


Thr Val Ser Asn Ile Gln Glu Ile Ala Glu Trp Met Asn Ala Glu Thr 
            180                 185                 190         


Val Val Ser Asn Phe Arg Ala Val Pro Leu Glu Thr Gly Ile Ile Phe 
        195                 200                 205             


Lys Gly Asn Leu Ile Thr Asp Gly Glu Lys Lys His Leu Gly Arg Asp 
    210                 215                 220                 


Asp Glu Val Ser Leu Ile Lys Glu Ser Ile Glu Ser Gly Gly Gln Ala 
225                 230                 235                 240 


Leu Val Phe Arg Asn Ser Arg Arg Asn Ala Glu Lys Tyr Ala Gln Ser 
                245                 250                 255     


Met Val Asn Phe Phe Asp Phe Gln Asn Asp Phe Glu Lys Leu Glu Ile 
            260                 265                 270         


Pro Pro Asp Leu Phe Asn Glu Ala Gln Ala Asn Met Val Ala His Gly 
        275                 280                 285             


Val Met Phe His His Ala Gly Leu Ser Asn Asp Gln Arg Thr Met Ile 
    290                 295                 300                 


Glu Lys Leu Phe Lys Gln Gly Tyr Ile Lys Ile Leu Thr Ala Thr Pro 
305                 310                 315                 320 


Thr Leu Ala Ala Gly Val Asn Leu Pro Ala Arg Thr Val Ile Ile Arg 
                325                 330                 335     


Asp Ile Thr Arg Phe Ser Asp Gly Tyr Ser Lys Pro Ile Ser Gly Ile 
            340                 345                 350         


Glu Ile Gln Gln Met Ile Gly Arg Ala Gly Arg Pro Lys Tyr Asp Lys 
        355                 360                 365             


Lys Gly Tyr Gly Tyr Ile Tyr Ala Ala Ser Pro Gly Met Leu Arg Val 
    370                 375                 380                 


Ala Glu Gly Tyr Leu Thr Gly Glu Leu Glu Pro Val Ile Ser Arg Met 
385                 390                 395                 400 


Asp Ser Asn Ser Leu Ile Arg Phe Asn Val Leu Ala Leu Ile Ser Ser 
                405                 410                 415     


Gly Ile Ala Thr Asp Leu Lys Gly Ile Gln Asp Phe Tyr Gly Lys Thr 
            420                 425                 430         


Leu Leu Ala Ala Gln Asn Asp Ile Asp Gly Tyr Glu Leu Ala Phe Glu 
        435                 440                 445             


Ser Ala Leu Tyr Phe Leu Lys Asp Asn Asp Phe Ile Thr Glu Glu Asn 
    450                 455                 460                 


Asp Ile Tyr Ser Ala Thr Lys Phe Gly Arg Leu Thr Ser Asp Leu Tyr 
465                 470                 475                 480 


Ile Asp Pro Val Ser Ser Leu Ile Leu Lys Lys Cys Leu Asp Leu Glu 
                485                 490                 495     


Phe Ser Glu Glu Leu Tyr Leu Tyr Tyr Ile Ser Lys Thr Pro Asp Met 
            500                 505                 510         


Leu Thr Phe Asn Tyr Arg Ala Ser Asp Tyr Glu Tyr Leu Glu Glu Phe 
        515                 520                 525             


Leu Asp Arg His Asn Ile Ser Asp Phe Ser Glu Glu Ser Met Gly Ala 
    530                 535                 540                 


Ala Lys Thr Ala Ile Ile Leu Asn Glu Trp Ile Asn Glu Val Pro Ile 
545                 550                 555                 560 


Asn Thr Ile Ala Glu Thr Phe Gly Ile Gly Pro Gly Asp Ile Gln Ala 
                565                 570                 575     


Lys Ala Ser Ser Ala Asp Trp Ile Ser Tyr Ser Leu Tyr Arg Leu Gly 
            580                 585                 590         


Ser Met Phe Asp Lys Glu Asn Glu Asn Asn Leu Leu His Leu Asn Ile 
        595                 600                 605             


Arg Ile Lys Glu Gly Val Lys Glu Glu Ile Ile Arg Ile Ile Glu Ile 
    610                 615                 620                 


Pro Gln Val Gly Arg Val Arg Gly Arg Arg Leu Tyr Asn Asn Gly Phe 
625                 630                 635                 640 


Lys Ser Ile Asp Asp Ile Ala Asn Ala Arg Val Glu Asp Ile Ser Arg 
                645                 650                 655     


Ile Phe Gly Phe Ser Thr Lys Leu Ala Lys Asp Ile Ile Glu Asn Ala 
            660                 665                 670         


Gly Lys Leu Asn Asn Arg Tyr Tyr Arg 
        675                 680     


<210>  49
<211>  696
<212>  PRT
<213>  Methanocaldococcus fervens

<400>  49

Met Pro Thr Asn Lys Ile Leu Glu Ile Leu Lys Asp Phe Gly Ile Glu 
1               5                   10                  15      


Glu Leu Arg Pro Pro Gln Lys Lys Ala Leu Glu Lys Gly Leu Leu Asp 
            20                  25                  30          


Lys Asn Lys Asn Phe Leu Ile Ser Ile Pro Thr Ala Ser Gly Lys Thr 
        35                  40                  45              


Leu Ile Gly Glu Met Ala Leu Ile Asn His Leu Leu Asp Glu Asn Lys 
    50                  55                  60                  


Asn Pro Thr Asn Lys Lys Gly Ile Phe Ile Val Pro Leu Lys Ala Leu 
65                  70                  75                  80  


Ala Ser Glu Lys Tyr Glu Glu Phe Lys Asn Lys Tyr Glu Arg Tyr Gly 
                85                  90                  95      


Leu Arg Val Ala Leu Ser Ile Gly Asp Tyr Asp Glu Asp Glu Asp Leu 
            100                 105                 110         


Ser Arg Tyr His Leu Ile Ile Thr Thr Ala Glu Lys Leu Asp Ser Leu 
        115                 120                 125             


Trp Arg His Lys Ile Asp Trp Ile Asp Asp Val Ser Val Val Val Val 
    130                 135                 140                 


Asp Glu Ile His Leu Ile Asn Asp Glu Ser Arg Gly Gly Thr Leu Glu 
145                 150                 155                 160 


Ile Leu Leu Thr Lys Leu Lys Lys Phe Asn Ile Gln Ile Ile Gly Leu 
                165                 170                 175     


Ser Ala Thr Ile Gly Asn Pro Glu Glu Leu Ala Asn Trp Leu Asn Ala 
            180                 185                 190         


Glu Leu Ile Val Asp Asp Trp Arg Pro Val Glu Leu Lys Lys Gly Ile 
        195                 200                 205             


Tyr Lys Asn Gly Ile Ile Glu Phe Ile Asn Gly Glu Asn Arg Glu Ile 
    210                 215                 220                 


Lys Ala Ile Asn Asn Asn Asp Ile Tyr Asn Leu Val Val Asp Cys Val 
225                 230                 235                 240 


Lys Asp Gly Gly Cys Cys Ile Val Phe Cys Asn Thr Lys Arg Gly Ala 
                245                 250                 255     


Val Asn Glu Ala Lys Lys Leu Asn Leu Lys Lys Phe Leu Thr Asn Glu 
            260                 265                 270         


Glu Lys Arg Lys Leu Lys Glu Val Ala Glu Glu Ile Leu Ser Ile Leu 
        275                 280                 285             


Glu Pro Pro Thr Glu Met Cys Lys Thr Leu Ala Glu Cys Ile Leu Asn 
    290                 295                 300                 


Gly Ser Ala Phe His His Ala Gly Leu Thr Tyr Gln His Arg Lys Ile 
305                 310                 315                 320 


Val Glu Asp Ala Phe Arg Asn Lys Leu Ile Lys Val Ile Cys Cys Thr 
                325                 330                 335     


Pro Thr Leu Ser Val Gly Leu Asn Leu Pro Cys Arg Arg Ala Ile Val 
            340                 345                 350         


Lys Asp Leu Thr Arg Tyr Thr Asn Arg Gly Met Arg Tyr Ile Pro Ile 
        355                 360                 365             


Met Glu Ile Gln Gln Cys Ile Gly Arg Ala Gly Arg Leu Gly Leu Asp 
    370                 375                 380                 


Pro Tyr Gly Glu Gly Ile Ile Val Ala Lys Asn Asp Arg Asp Tyr Leu 
385                 390                 395                 400 


Arg Ser Tyr Gln Val Leu Thr Gln Lys Pro Glu Pro Ile Tyr Ser Lys 
                405                 410                 415     


Leu Ser Asn Gln Ala Val Leu Arg Thr Gln Leu Leu Gly Leu Ile Ala 
            420                 425                 430         


Thr Ile Glu Ile Arg Asp Glu Tyr Asp Leu Glu Trp Phe Ile Arg Asn 
        435                 440                 445             


Thr Phe Tyr Ala Tyr Gln Tyr Gly Asn Leu Arg Glu Val Ala Lys Asn 
    450                 455                 460                 


Ile Asn Glu Val Ile Arg Phe Leu Glu Glu Lys Glu Phe Met Ile Asp 
465                 470                 475                 480 


Phe Ile Pro Thr Glu Leu Gly Lys Arg Val Ala Glu Leu Tyr Ile Asp 
                485                 490                 495     


Pro Leu Ser Ala Lys Tyr Met Ile Asp Gly Leu Asn Glu Met Glu Asn 
            500                 505                 510         


Glu Asp Asp Ile Tyr Tyr Leu Tyr Leu Ile Ser Lys Thr Leu Glu Met 
        515                 520                 525             


Met Pro Asn Leu Arg Val Tyr Lys Ser Glu Glu Leu Asn Leu Ile Asp 
    530                 535                 540                 


Glu Met Glu Asn Leu Gly Ile Lys Ser Phe Glu Ile Glu Asp Leu Glu 
545                 550                 555                 560 


Ala Phe Lys Thr Ala Lys Met Leu Tyr Asp Trp Ile Ser Glu Val Pro 
                565                 570                 575     


Glu Asp Glu Ile Leu Lys Lys Tyr Lys Ile Glu Pro Gly Ile Leu Arg 
            580                 585                 590         


Tyr Lys Val Glu Asn Ala Val Trp Leu Met His Ala Leu Lys Glu Met 
        595                 600                 605             


Ala Lys Ile Ile Gly Lys Asn Ser Glu Ile Pro Glu Lys Leu Glu Ile 
    610                 615                 620                 


Arg Leu Glu Tyr Gly Ala Lys Glu Asp Ile Ile Glu Leu Leu Asn Val 
625                 630                 635                 640 


Lys Tyr Ile Gly Arg Val Arg Ala Arg Lys Leu Tyr Asn Ala Gly Ile 
                645                 650                 655     


Arg Asn Val Glu Asp Ile Ile Asn Asn Pro Ser Lys Val Ala Ser Ile 
            660                 665                 670         


Ile Gly Glu Lys Ile Thr Lys Lys Ile Leu Glu Asp Leu Gly Ile Lys 
        675                 680                 685             


Phe Gly Gln Gln Lys Leu Ile Phe 
    690                 695     


<210>  50
<211>  729
<212>  PRT
<213>  Methanocaldococcus jannaschii

<400>  50

Met Asp Lys Ile Leu Glu Ile Leu Lys Asp Phe Gly Ile Val Glu Leu 
1               5                   10                  15      


Arg Pro Pro Gln Lys Lys Ala Leu Glu Arg Gly Leu Leu Asp Lys Asn 
            20                  25                  30          


Lys Asn Phe Leu Ile Ser Ile Pro Thr Ala Ser Gly Lys Thr Leu Ile 
        35                  40                  45              


Gly Glu Met Ala Leu Ile Asn His Leu Leu Asp Gly Asn Lys Asn Pro 
    50                  55                  60                  


Thr Asn Lys Lys Gly Ile Phe Ile Val Pro Leu Lys Ala Leu Ala Ser 
65                  70                  75                  80  


Glu Lys Tyr Glu Glu Phe Lys Ser Lys Tyr Glu Arg Tyr Gly Leu Arg 
                85                  90                  95      


Ile Ala Leu Ser Ile Gly Asp Tyr Asp Glu Asp Glu Asp Leu Ser Lys 
            100                 105                 110         


Tyr His Leu Ile Ile Thr Thr Ala Glu Lys Leu Asp Ser Leu Trp Arg 
        115                 120                 125             


His Lys Ile Asp Trp Ile Asn Asp Val Ser Val Val Val Val Asp Glu 
    130                 135                 140                 


Ile His Leu Ile Asn Asp Glu Thr Arg Gly Gly Thr Leu Glu Ile Leu 
145                 150                 155                 160 


Leu Thr Lys Leu Lys Glu Phe Asn Val Gln Ile Ile Gly Leu Ser Ala 
                165                 170                 175     


Thr Ile Gly Asn Pro Asp Glu Leu Ala Glu Trp Leu Asn Ala Glu Leu 
            180                 185                 190         


Ile Val Asp Asp Trp Arg Pro Val Glu Leu Lys Lys Gly Ile Tyr Lys 
        195                 200                 205             


Asn Glu Ala Ile Glu Phe Ile Asn Gly Glu Ile Arg Glu Ile Lys Ala 
    210                 215                 220                 


Val Asp Asn Asn Asp Ile Tyr Asn Leu Val Val Asp Cys Val Lys Glu 
225                 230                 235                 240 


Gly Gly Cys Cys Leu Val Phe Cys Asn Thr Lys Arg Asn Ala Val Asn 
                245                 250                 255     


Glu Ala Lys Lys Leu Asn Leu Lys Lys Phe Leu Thr Glu Glu Glu Lys 
            260                 265                 270         


Ile Arg Leu Lys Glu Ile Ala Glu Glu Ile Leu Ser Ile Leu Glu Pro 
        275                 280                 285             


Pro Thr Glu Met Cys Lys Thr Leu Ala Glu Cys Ile Leu Asn Gly Ser 
    290                 295                 300                 


Ala Phe His His Ala Gly Leu Thr Tyr Gln His Arg Lys Ile Val Glu 
305                 310                 315                 320 


Asp Ala Phe Arg Lys Arg Leu Ile Lys Val Ile Cys Cys Thr Pro Thr 
                325                 330                 335     


Leu Ser Ala Gly Leu Asn Leu Pro Cys Arg Arg Ala Ile Val Lys Asp 
            340                 345                 350         


Leu Thr Arg Phe Thr Asn Lys Gly Met Arg Tyr Ile Pro Ile Met Glu 
        355                 360                 365             


Ile Gln Gln Cys Ile Gly Arg Ala Gly Arg Pro Gly Leu Asp Pro Tyr 
    370                 375                 380                 


Gly Glu Gly Ile Ile Val Ala Lys Asn Asp Arg Asp Tyr Leu Arg Ala 
385                 390                 395                 400 


Tyr Gln Ala Leu Thr Gln Lys Pro Glu Pro Ile Tyr Ser Lys Leu Ser 
                405                 410                 415     


Asn Gln Ala Val Leu Arg Thr Gln Leu Leu Gly Leu Ile Ala Thr Gly 
            420                 425                 430         


Glu Ile Arg Asp Glu Tyr Asp Leu Glu Trp Phe Ile Arg Asn Thr Phe 
        435                 440                 445             


Tyr Ala His Gln Tyr Gly Asn Leu Arg Glu Val Ala Lys Asn Ile Asn 
    450                 455                 460                 


Glu Val Ile Arg Phe Leu Glu Glu Asn Glu Phe Ile Ile Asp Phe Met 
465                 470                 475                 480 


Pro Thr Glu Leu Gly Lys Arg Val Ser Glu Leu Tyr Ile Asp Pro Leu 
                485                 490                 495     


Ser Ala Lys Phe Ile Ile Asp Gly Leu Glu Glu Met Glu Asn Glu Glu 
            500                 505                 510         


Glu Ile Tyr Tyr Leu Tyr Leu Ile Ser Lys Thr Leu Glu Met Met Pro 
        515                 520                 525             


Asn Leu Arg Val Tyr Asn Ser Glu Glu Leu Asn Leu Ile Asp Glu Met 
    530                 535                 540                 


Asp Ser Leu Gly Ile Lys Ser Phe Glu Ile Glu Asp Leu Glu Ala Phe 
545                 550                 555                 560 


Lys Thr Ala Lys Met Leu Tyr Asp Trp Ile Asn Glu Val Pro Glu Asp 
                565                 570                 575     


Glu Ile Leu Lys Arg Tyr Lys Ile Glu Pro Gly Ile Leu Arg Tyr Lys 
            580                 585                 590         


Val Glu Asn Ala Val Trp Ile Met His Ala Leu Lys Glu Ile Ala Lys 
        595                 600                 605             


Leu Ile Gly Lys Ser Ser Asp Ile Pro Glu Lys Leu Glu Ile Arg Leu 
    610                 615                 620                 


Glu Tyr Gly Ala Lys Glu Asp Ile Ile Glu Leu Leu Ser Ile Lys Tyr 
625                 630                 635                 640 


Ile Gly Arg Val Arg Ala Arg Lys Leu Tyr Asn Ala Gly Ile Arg Ser 
                645                 650                 655     


Ile Glu Asp Ile Ile Asn Asn Pro Ser Lys Val Ala Ser Ile Ile Gly 
            660                 665                 670         


Glu Lys Ile Ala Lys Lys Ile Leu Asp Glu Leu Gly Val Lys Phe Gly 
        675                 680                 685             


Gln Gln Lys Leu Ser Phe Ser Gly Gly Ser Ala Trp Ser His Pro Gln 
    690                 695                 700                 


Phe Glu Lys Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Ser Ala Trp 
705                 710                 715                 720 


Ser His Pro Gln Phe Glu Lys Lys Leu 
                725                 


<210>  51
<211>  670
<212>  PRT
<213>  Methanocaldococcus infernus

<400>  51

Met Asp Glu Ile Leu Lys Phe Leu Gly Ile Lys Glu Leu Arg Pro Pro 
1               5                   10                  15      


Gln Lys Lys Ala Leu Glu Leu Gly Ile Leu Asp Lys Lys Lys Asn Phe 
            20                  25                  30          


Leu Ile Ser Ile Pro Thr Gly Ala Gly Lys Thr Val Ile Ala Glu Met 
        35                  40                  45              


Ala Leu Ile Asn His Leu Leu Leu Asp Lys Gly Lys Lys Gly Val Tyr 
    50                  55                  60                  


Ile Val Pro Leu Lys Ala Leu Ala Ser Glu Lys Tyr Glu Glu Phe Lys 
65                  70                  75                  80  


Lys Lys Tyr Glu Lys Phe Gly Val Arg Val Ala Leu Ser Ile Gly Asp 
                85                  90                  95      


Tyr Asp Glu Asp Glu Asp Leu Glu Asn Tyr Asp Leu Ile Ile Thr Thr 
            100                 105                 110         


Ala Glu Lys Phe Asp Ser Leu Trp Arg His Gly Ile Lys Leu Ser Asp 
        115                 120                 125             


Ile Ser Val Val Val Val Asp Glu Ile His Val Ile Gly Asp Ser Glu 
    130                 135                 140                 


Arg Gly Gly Thr Leu Glu Val Leu Leu Thr Lys Leu Lys Glu Leu Asp 
145                 150                 155                 160 


Val Gln Ile Ile Gly Leu Ser Ala Thr Ile Gly Asn Pro Glu Glu Leu 
                165                 170                 175     


Ser Glu Trp Leu Asn Ala Glu Leu Leu Leu Asp Asn Trp Arg Pro Val 
            180                 185                 190         


Glu Leu Arg Lys Gly Ile Tyr Arg Glu Gly Val Ile Glu Tyr Leu Asp 
        195                 200                 205             


Gly Glu Val Lys Glu Cys Gln Asp Ile Val Lys Glu Val Val Lys Asp 
    210                 215                 220                 


Asn Gly Ser Val Ile Ile Phe Cys Pro Thr Lys Lys Lys Ala Glu Asn 
225                 230                 235                 240 


Arg Ala Leu Ser Leu Asp Leu Ser Asp Leu Leu Lys Lys Ser Glu Lys 
                245                 250                 255     


Arg Lys Leu Glu Glu Ile Ser Glu Glu Leu Leu Ser Leu Phe Asp Pro 
            260                 265                 270         


Pro Thr Glu Leu Cys Lys Lys Leu Ala Ser Cys Val Arg Lys Gly Ile 
        275                 280                 285             


Ala Phe His His Ser Gly Leu Thr Tyr Glu His Arg Lys Ile Ile Glu 
    290                 295                 300                 


Lys Ala Phe Arg Glu Arg Ile Leu Lys Val Ile Cys Ser Thr Thr Thr 
305                 310                 315                 320 


Leu Ala Phe Gly Leu Asn Leu Pro Cys Arg Arg Val Ile Ile Ser Glu 
                325                 330                 335     


Leu Lys Arg Tyr Thr Arg Arg Gly Leu Thr Tyr Ile Pro Ile Met Glu 
            340                 345                 350         


Val Gln Gln Cys Ile Gly Arg Ala Gly Arg Pro Gly Leu Asp Glu Tyr 
        355                 360                 365             


Gly Glu Gly Ile Leu Val Ala Lys Asp Glu Arg Asp Tyr Leu Arg Ala 
    370                 375                 380                 


Leu Gln Cys Leu Thr Gln Lys Pro Glu Pro Ile Tyr Ser Lys Leu Ser 
385                 390                 395                 400 


Asn Asp Ser Val Leu Arg Thr Gln Ile Leu Gly Leu Ile Ala Thr Arg 
                405                 410                 415     


Tyr Val Leu Asp Glu Tyr Asp Leu Glu Glu Phe Ile Lys Asn Thr Phe 
            420                 425                 430         


Tyr Ala Tyr Gln Tyr Lys Asn Leu Asp Glu Ile Lys Lys Lys Ile Lys 
        435                 440                 445             


Glu Ile Ile Glu Phe Leu Glu Asp Cys Asn Phe Ile Lys Asn Phe Glu 
    450                 455                 460                 


Val Thr Pro Leu Gly Lys Lys Val Ser Asn Leu Tyr Leu Asp Pro Leu 
465                 470                 475                 480 


Ser Ala Lys Ile Met Ile Asp Asn Ile Glu Val Lys Asp Asp Leu His 
                485                 490                 495     


Leu Leu Tyr Ile Leu Cys Lys Cys Ile Glu Met Lys Pro Leu Leu Arg 
            500                 505                 510         


Val Tyr Arg Lys Glu Glu Glu Glu Leu Ala Glu Glu Leu Leu Asn Tyr 
        515                 520                 525             


Glu Ile Phe Ile Ser Tyr Glu Asn Leu Glu Glu Phe Lys Thr Ala Lys 
    530                 535                 540                 


Met Leu Tyr Asp Trp Ile Asn Glu Val Pro Glu Asp Glu Ile Leu Lys 
545                 550                 555                 560 


Thr Tyr Lys Val Glu Pro Gly Ile Leu Arg Tyr Lys Val Glu Val Ala 
                565                 570                 575     


Lys Trp Leu Ser Tyr Ser Leu Lys Glu Ile Ala Lys Ile Leu Asn Lys 
            580                 585                 590         


Glu Val Pro Asn Leu Glu Leu Arg Leu Glu Tyr Gly Ala Lys Glu Glu 
        595                 600                 605             


Leu Leu Glu Leu Leu Lys Ile Lys Tyr Ile Gly Arg Val Arg Ala Arg 
    610                 615                 620                 


Lys Leu Tyr Ser Ala Gly Ile Arg Asn Arg Glu Asp Ile Ile Lys Asn 
625                 630                 635                 640 


Pro Lys Lys Val Ala Asn Ile Leu Gly Glu Lys Ile Ser Lys Lys Ile 
                645                 650                 655     


Phe Glu Glu Leu Gly Val Arg Tyr Gly Gln Gln Arg Leu Ile 
            660                 665                 670 


<210>  52
<211>  799
<212>  PRT
<213>  Methanospirillum hungatei

<400>  52

Met Glu Ile Ala Ser Leu Pro Leu Pro Asp Ser Phe Ile Arg Ala Cys 
1               5                   10                  15      


His Ala Lys Gly Ile Arg Ser Leu Tyr Pro Pro Gln Ala Glu Cys Ile 
            20                  25                  30          


Glu Lys Gly Leu Leu Glu Gly Lys Asn Leu Leu Ile Ser Ile Pro Thr 
        35                  40                  45              


Ala Ser Gly Lys Thr Leu Leu Ala Glu Met Ala Met Trp Ser Arg Ile 
    50                  55                  60                  


Ala Ala Gly Gly Lys Cys Leu Tyr Ile Val Pro Leu Arg Ala Leu Ala 
65                  70                  75                  80  


Ser Glu Lys Tyr Asp Glu Phe Ser Lys Lys Gly Val Ile Arg Val Gly 
                85                  90                  95      


Ile Ala Thr Gly Asp Leu Asp Arg Thr Asp Ala Tyr Leu Gly Glu Asn 
            100                 105                 110         


Asp Ile Ile Val Ala Thr Ser Glu Lys Thr Asp Ser Leu Leu Arg Asn 
        115                 120                 125             


Arg Thr Pro Trp Leu Ser Gln Ile Thr Cys Ile Val Leu Asp Glu Val 
    130                 135                 140                 


His Leu Ile Gly Ser Glu Asn Arg Gly Ala Thr Leu Glu Met Val Ile 
145                 150                 155                 160 


Thr Lys Leu Arg Tyr Thr Asn Pro Val Met Gln Ile Ile Gly Leu Ser 
                165                 170                 175     


Ala Thr Ile Gly Asn Pro Ala Gln Leu Ala Glu Trp Leu Asp Ala Thr 
            180                 185                 190         


Leu Ile Thr Ser Thr Trp Arg Pro Val Asp Leu Arg Gln Gly Val Tyr 
        195                 200                 205             


Tyr Asn Gly Lys Ile Arg Phe Ser Asp Ser Glu Arg Pro Ile Gln Gly 
    210                 215                 220                 


Lys Thr Lys His Asp Asp Leu Asn Leu Cys Leu Asp Thr Ile Glu Glu 
225                 230                 235                 240 


Gly Gly Gln Cys Leu Val Phe Val Ser Ser Arg Arg Asn Ala Glu Gly 
                245                 250                 255     


Phe Ala Lys Lys Ala Ala Gly Ala Leu Lys Ala Gly Ser Pro Asp Ser 
            260                 265                 270         


Lys Ala Leu Ala Gln Glu Leu Arg Arg Leu Arg Asp Arg Asp Glu Gly 
        275                 280                 285             


Asn Val Leu Ala Asp Cys Val Glu Arg Gly Ala Ala Phe His His Ala 
    290                 295                 300                 


Gly Leu Ile Arg Gln Glu Arg Thr Ile Ile Glu Glu Gly Phe Arg Asn 
305                 310                 315                 320 


Gly Tyr Ile Glu Val Ile Ala Ala Thr Pro Thr Leu Ala Ala Gly Leu 
                325                 330                 335     


Asn Leu Pro Ala Arg Arg Val Ile Ile Arg Asp Tyr Asn Arg Phe Ala 
            340                 345                 350         


Ser Gly Leu Gly Met Val Pro Ile Pro Val Gly Glu Tyr His Gln Met 
        355                 360                 365             


Ala Gly Arg Ala Gly Arg Pro His Leu Asp Pro Tyr Gly Glu Ala Val 
    370                 375                 380                 


Leu Leu Ala Lys Asp Ala Pro Ser Val Glu Arg Leu Phe Glu Thr Phe 
385                 390                 395                 400 


Ile Asp Ala Glu Ala Glu Arg Val Asp Ser Gln Cys Val Asp Asp Ala 
                405                 410                 415     


Ser Leu Cys Ala His Ile Leu Ser Leu Ile Ala Thr Gly Phe Ala His 
            420                 425                 430         


Asp Gln Glu Ala Leu Ser Ser Phe Met Glu Arg Thr Phe Tyr Phe Phe 
        435                 440                 445             


Gln His Pro Lys Thr Arg Ser Leu Pro Arg Leu Val Ala Asp Ala Ile 
    450                 455                 460                 


Arg Phe Leu Thr Thr Ala Gly Met Val Glu Glu Arg Glu Asn Thr Leu 
465                 470                 475                 480 


Ser Ala Thr Arg Leu Gly Ser Leu Val Ser Arg Leu Tyr Leu Asn Pro 
                485                 490                 495     


Cys Thr Ala Arg Leu Ile Leu Asp Ser Leu Lys Ser Cys Lys Thr Pro 
            500                 505                 510         


Thr Leu Ile Gly Leu Leu His Val Ile Cys Val Ser Pro Asp Met Gln 
        515                 520                 525             


Arg Leu Tyr Leu Lys Ala Ala Asp Thr Gln Leu Leu Arg Thr Phe Leu 
    530                 535                 540                 


Phe Lys His Lys Asp Asp Leu Ile Leu Pro Leu Pro Phe Glu Gln Glu 
545                 550                 555                 560 


Glu Glu Glu Leu Trp Leu Ser Gly Leu Lys Thr Ala Leu Val Leu Thr 
                565                 570                 575     


Asp Trp Ala Asp Glu Phe Ser Glu Gly Met Ile Glu Glu Arg Tyr Gly 
            580                 585                 590         


Ile Gly Ala Gly Asp Leu Tyr Asn Ile Val Asp Ser Gly Lys Trp Leu 
        595                 600                 605             


Leu His Gly Thr Glu Arg Leu Val Ser Val Glu Met Pro Glu Met Ser 
    610                 615                 620                 


Gln Val Val Lys Thr Leu Ser Val Arg Val His His Gly Val Lys Ser 
625                 630                 635                 640 


Glu Leu Leu Pro Leu Val Ala Leu Arg Asn Ile Gly Arg Val Arg Ala 
                645                 650                 655     


Arg Thr Leu Tyr Asn Ala Gly Tyr Pro Asp Pro Glu Ala Val Ala Arg 
            660                 665                 670         


Ala Gly Leu Ser Thr Ile Ala Arg Ile Ile Gly Glu Gly Ile Ala Arg 
        675                 680                 685             


Gln Val Ile Asp Glu Ile Thr Gly Val Lys Arg Ser Gly Ile His Ser 
    690                 695                 700                 


Ser Asp Asp Asp Tyr Gln Gln Lys Thr Pro Glu Leu Leu Thr Asp Ile 
705                 710                 715                 720 


Pro Gly Ile Gly Lys Lys Met Ala Glu Lys Leu Gln Asn Ala Gly Ile 
                725                 730                 735     


Ile Thr Val Ser Asp Leu Leu Thr Ala Asp Glu Val Leu Leu Ser Asp 
            740                 745                 750         


Val Leu Gly Ala Ala Arg Ala Arg Lys Val Leu Ala Phe Leu Ser Asn 
        755                 760                 765             


Ser Glu Lys Glu Asn Ser Ser Ser Asp Lys Thr Glu Glu Ile Pro Asp 
    770                 775                 780                 


Thr Gln Lys Ile Arg Gly Gln Ser Ser Trp Glu Asp Phe Gly Cys 
785                 790                 795                 


<210>  53
<211>  702
<212>  PRT
<213>  Archaeoglobus fulgidus

<400>  53

Met Lys Val Glu Glu Leu Ala Glu Ser Ile Ser Ser Tyr Ala Val Gly 
1               5                   10                  15      


Ile Leu Lys Glu Glu Gly Ile Glu Glu Leu Phe Pro Pro Gln Ala Glu 
            20                  25                  30          


Ala Val Glu Lys Val Phe Ser Gly Lys Asn Leu Leu Leu Ala Met Pro 
        35                  40                  45              


Thr Ala Ala Gly Lys Thr Leu Leu Ala Glu Met Ala Met Val Arg Glu 
    50                  55                  60                  


Ala Ile Lys Gly Gly Lys Ser Leu Tyr Val Val Pro Leu Arg Ala Leu 
65                  70                  75                  80  


Ala Gly Glu Lys Tyr Glu Ser Phe Lys Lys Trp Glu Lys Ile Gly Leu 
                85                  90                  95      


Arg Ile Gly Ile Ser Thr Gly Asp Tyr Glu Ser Arg Asp Glu His Leu 
            100                 105                 110         


Gly Asp Cys Asp Ile Ile Val Thr Thr Ser Glu Lys Ala Asp Ser Leu 
        115                 120                 125             


Ile Arg Asn Arg Ala Ser Trp Ile Lys Ala Val Ser Cys Leu Val Val 
    130                 135                 140                 


Asp Glu Ile His Leu Leu Asp Ser Glu Lys Arg Gly Ala Thr Leu Glu 
145                 150                 155                 160 


Ile Leu Val Thr Lys Met Arg Arg Met Asn Lys Ala Leu Arg Val Ile 
                165                 170                 175     


Gly Leu Ser Ala Thr Ala Pro Asn Val Thr Glu Ile Ala Glu Trp Leu 
            180                 185                 190         


Asp Ala Asp Tyr Tyr Val Ser Asp Trp Arg Pro Val Pro Leu Val Glu 
        195                 200                 205             


Gly Val Leu Cys Glu Gly Thr Leu Glu Leu Phe Asp Gly Ala Phe Ser 
    210                 215                 220                 


Thr Ser Arg Arg Val Lys Phe Glu Glu Leu Val Glu Glu Cys Val Ala 
225                 230                 235                 240 


Glu Asn Gly Gly Val Leu Val Phe Glu Ser Thr Arg Arg Gly Ala Glu 
                245                 250                 255     


Lys Thr Ala Val Lys Leu Ser Ala Ile Thr Ala Lys Tyr Val Glu Asn 
            260                 265                 270         


Glu Gly Leu Glu Lys Ala Ile Leu Glu Glu Asn Glu Gly Glu Met Ser 
        275                 280                 285             


Arg Lys Leu Ala Glu Cys Val Arg Lys Gly Ala Ala Phe His His Ala 
    290                 295                 300                 


Gly Leu Leu Asn Gly Gln Arg Arg Val Val Glu Asp Ala Phe Arg Arg 
305                 310                 315                 320 


Gly Asn Ile Lys Val Val Val Ala Thr Pro Thr Leu Ala Ala Gly Val 
                325                 330                 335     


Asn Leu Pro Ala Arg Arg Val Ile Val Arg Ser Leu Tyr Arg Phe Asp 
            340                 345                 350         


Gly Tyr Ser Lys Arg Ile Lys Val Ser Glu Tyr Lys Gln Met Ala Gly 
        355                 360                 365             


Arg Ala Gly Arg Pro Gly Met Asp Glu Arg Gly Glu Ala Ile Ile Ile 
    370                 375                 380                 


Val Gly Lys Arg Asp Arg Glu Ile Ala Val Lys Arg Tyr Ile Phe Gly 
385                 390                 395                 400 


Glu Pro Glu Arg Ile Thr Ser Lys Leu Gly Val Glu Thr His Leu Arg 
                405                 410                 415     


Phe His Ser Leu Ser Ile Ile Cys Asp Gly Tyr Ala Lys Thr Leu Glu 
            420                 425                 430         


Glu Leu Glu Asp Phe Phe Ala Asp Thr Phe Phe Phe Lys Gln Asn Glu 
        435                 440                 445             


Ile Ser Leu Ser Tyr Glu Leu Glu Arg Val Val Arg Gln Leu Glu Asn 
    450                 455                 460                 


Trp Gly Met Val Val Glu Asp His His Leu Ala Pro Thr Lys Leu Gly 
465                 470                 475                 480 


Ser Leu Val Ser Arg Leu Tyr Ile Asp Pro Leu Thr Gly Phe Ile Phe 
                485                 490                 495     


His Asp Val Leu Ser Arg Met Glu Leu Ser Asp Ile Gly Ala Leu His 
            500                 505                 510         


Leu Ile Cys Arg Thr Pro Asp Met Glu Arg Leu Thr Val Arg Lys Thr 
        515                 520                 525             


Asp Ser Trp Val Glu Glu Glu Ala Phe Arg Leu Arg Lys Glu Leu Ser 
    530                 535                 540                 


Tyr Tyr Pro Ser Asp Phe Ser Val Glu Tyr Asp Trp Phe Leu Ser Glu 
545                 550                 555                 560 


Val Lys Thr Ala Leu Cys Leu Lys Asp Trp Ile Glu Glu Lys Asp Glu 
                565                 570                 575     


Asp Glu Ile Cys Ala Lys Tyr Gly Ile Ala Pro Gly Asp Leu Arg Arg 
            580                 585                 590         


Ile Val Glu Thr Ala Glu Trp Leu Ser Asn Ala Met Asn Arg Ile Ala 
        595                 600                 605             


Glu Glu Val Gly Asn Thr Ser Val Ser Gly Leu Thr Glu Arg Ile Lys 
    610                 615                 620                 


His Gly Val Lys Glu Glu Leu Leu Glu Leu Val Arg Ile Arg His Ile 
625                 630                 635                 640 


Gly Arg Val Arg Ala Arg Lys Leu Tyr Asn Ala Gly Ile Arg Asn Ala 
                645                 650                 655     


Glu Asp Ile Val Arg His Arg Glu Lys Val Ala Ser Leu Ile Gly Arg 
            660                 665                 670         


Gly Ile Ala Glu Arg Val Val Glu Gly Ile Ser Val Lys Ser Leu Asn 
        675                 680                 685             


Pro Glu Ser Ala Ala Ala Leu Glu His His His His His His 
    690                 695                 700         


<210>  54
<211>  791
<212>  PRT
<213>  Haloterrigena turkmenica

<400>  54

Met Asn Leu Glu Glu Leu Thr Gly Leu Pro Pro Gly Ala Thr Asp His 
1               5                   10                  15      


Phe Arg Gly Glu Gly Ile Glu Glu Leu Tyr Pro Pro Gln Ala Asp Ala 
            20                  25                  30          


Val Glu Ala Gly Ala Thr Asp Gly Glu Asn Leu Val Ala Ala Val Pro 
        35                  40                  45              


Thr Ala Ser Gly Lys Thr Met Ile Ala Ala Leu Ser Met Leu Ser Ala 
    50                  55                  60                  


Val Gln Arg Gly Gly Lys Ala Leu Tyr Ile Val Pro Leu Arg Ala Leu 
65                  70                  75                  80  


Ala Ser Glu Lys Lys Glu Glu Phe Glu Ala Tyr Glu Glu Phe Gly Val 
                85                  90                  95      


Thr Thr Gly Val Thr Thr Gly Asn Tyr Glu Ser Thr Asp Asp Trp Leu 
            100                 105                 110         


Ala Thr Lys Asp Ile Ile Val Ala Thr Ser Glu Lys Val Asp Ser Leu 
        115                 120                 125             


Val Arg Asn Gly Ala Asp Trp Leu Ser Glu Leu Thr Cys Val Val Ser 
    130                 135                 140                 


Asp Glu Val His Leu Ile Asp Asp Arg Asn Arg Gly Pro Thr Leu Glu 
145                 150                 155                 160 


Val Thr Leu Ala Lys Leu Arg Arg Leu Asn Pro Gly Met Gln Val Val 
                165                 170                 175     


Ala Leu Ser Ala Thr Val Gly Asn Ala Asp Glu Ile Ala Asp Trp Leu 
            180                 185                 190         


Asp Ala Ser Leu Val Asp Thr Asp Trp Arg Pro Ile Asp Leu Gln Met 
        195                 200                 205             


Gly Val His Tyr Gly Asn Ala Leu Asn Phe Asp Asp Gly Ser Thr Arg 
    210                 215                 220                 


Glu Val Pro Val Glu Gly Ser Glu Lys Gln Glu Ala Ala Leu Val Arg 
225                 230                 235                 240 


Asp Ile Leu Arg Glu Gly Gly Ser Ser Leu Val Phe Val Asn Ser Arg 
                245                 250                 255     


Arg Asn Ala Glu Gly Ala Ala Lys Arg Leu Gly Gln Val Ser Ser Arg 
            260                 265                 270         


Glu Ile Thr Glu Asp Glu Arg Ala Glu Leu Ala Glu Leu Ala Asp Asp 
        275                 280                 285             


Ile Arg Asp Asp Ser Asp Thr Glu Thr Ser Ala Asp Leu Ala Asp Cys 
    290                 295                 300                 


Val Glu Arg Gly Ala Ala Phe His His Ala Gly Leu Ser Ser Thr Gln 
305                 310                 315                 320 


Arg Ser Leu Val Glu Asp Ala Phe Arg Asp Arg Leu Leu Lys Val Ile 
                325                 330                 335     


Ser Ala Thr Pro Thr Leu Ala Ala Gly Val Asn Thr Pro Ala Arg Arg 
            340                 345                 350         


Val Ile Val Arg Asp Trp Arg Arg Phe Asp Pro Ser Ala Gly Gly Met 
        355                 360                 365             


Ala Pro Leu Asp Val Leu Glu Val His Gln Met Met Gly Arg Ala Gly 
    370                 375                 380                 


Arg Pro Gly Leu Asp Pro Tyr Gly Glu Ala Val Leu Leu Ala Lys Ser 
385                 390                 395                 400 


His Asp Glu Ser Glu Glu Leu Phe Asp Arg Tyr Ile Trp Ala Asp Pro 
                405                 410                 415     


Glu Pro Val Arg Ser Lys Leu Ala Ala Glu Pro Ala Leu Arg Thr His 
            420                 425                 430         


Val Leu Ala Thr Ile Ala Ser Gly Phe Ala Arg Thr Arg Gly Gly Leu 
        435                 440                 445             


Leu Glu Phe Leu Glu Ala Thr Leu Tyr Ala Ser Gln Ser Ser Glu Ala 
    450                 455                 460                 


Gly Arg Leu Glu Ser Val Thr Asp Asp Val Leu Asp Tyr Leu Glu Arg 
465                 470                 475                 480 


Asn Asp Phe Ile Glu Arg Ser Arg Asp Asp Glu Ala Glu Asp Ser Gly 
                485                 490                 495     


Glu Asp Asp Gly Pro Phe Thr Ser Ala Ala Asp Leu Ala Glu Gln Gln 
            500                 505                 510         


Ala Ala Lys Arg Glu Glu Thr Leu Glu Ala Thr Ser Leu Gly His Thr 
        515                 520                 525             


Val Ser Arg Leu Tyr Leu Asp Pro Met Ser Ala Ala Glu Ile Val His 
    530                 535                 540                 


Gly Leu Glu Arg Ala Asp Glu Arg Pro Thr Ala Leu Gly Leu Tyr Gln 
545                 550                 555                 560 


Leu Val Ser Arg Thr Pro Asp Met Tyr Glu Leu Tyr Leu Arg Ser Gly 
                565                 570                 575     


Glu Asp Glu Lys Phe Gly Glu Leu Phe Tyr Glu Arg Glu Thr Glu Leu 
            580                 585                 590         


Leu Gly Asp Ala Pro Ser Glu Tyr Glu Glu Asp Arg Phe Glu Asp Trp 
        595                 600                 605             


Leu Ala Ala Leu Lys Thr Gly Lys Leu Leu Glu Asp Trp Ala Asp Glu 
    610                 615                 620                 


Thr Asp Glu Glu Thr Ile Thr Asp Arg Tyr Lys Ile Gly Pro Gly Asp 
625                 630                 635                 640 


Leu Arg Gly Lys Val Asp Thr Ala Glu Trp Leu Leu Gly Ala Ala Glu 
                645                 650                 655     


Ser Leu Ala Ala Glu Ile Asp Ser Glu Trp Thr Val Ala Val Arg Glu 
            660                 665                 670         


Ala Arg Ala Arg Val Glu His Gly Val Gly Glu Glu Leu Leu Glu Leu 
        675                 680                 685             


Val Ser Val Gly Gly Val Gly Arg Lys Arg Ala Arg Arg Leu Tyr Asp 
    690                 695                 700                 


Ala Gly Ile Glu Glu Pro Ala Asp Leu Arg Ser Ala Asp Lys Gly Ile 
705                 710                 715                 720 


Val Leu Ser Val Leu Lys Gly Glu Lys Thr Ala Glu Asn Ile Leu Glu 
                725                 730                 735     


Asn Ala Gly Arg Glu Asp Pro Ser Met Asp Gly Val Glu Pro Ala Asp 
            740                 745                 750         


Gly Gly Pro Ala Val Gly Ala Ala Thr Asn Gly Ser Ser Gly Gly Ser 
        755                 760                 765             


Glu Thr Asp Glu Thr Gly Arg Ala Asp Ala Ala Glu Ser Asp Asp Ser 
    770                 775                 780                 


Gln Ser Ser Leu Gly Asp Phe 
785                 790     


<210>  55
<211>  752
<212>  PRT
<213>  Haladaptatus paucihalophilus

<400>  55

Met Asn Val Ala Asp Leu Thr Gly Leu Pro Asp Gly Val Pro Glu His 
1               5                   10                  15      


Phe His Ala Gln Gly Ile Glu Glu Leu Tyr Pro Pro Gln Ala Glu Ala 
            20                  25                  30          


Val Glu Ala Gly Ile Thr Glu Gly Glu Ser Val Val Ala Ser Ile Pro 
        35                  40                  45              


Thr Ala Ser Gly Lys Thr Phe Ile Ala Glu Leu Ala Met Leu Ser Ser 
    50                  55                  60                  


Val Ala Arg Gly Gly Lys Ala Leu Tyr Ile Val Pro Leu Arg Ala Leu 
65                  70                  75                  80  


Ala Ser Glu Lys Lys Glu Glu Phe Glu Glu Phe Glu Gln Tyr Gly Val 
                85                  90                  95      


Ser Ile Gly Val Ser Thr Gly Asn Tyr Glu Ser Asp Gly Asp Trp Leu 
            100                 105                 110         


Ala Ser Arg Asp Ile Ile Val Ala Thr Ser Glu Lys Val Asp Ser Leu 
        115                 120                 125             


Val Arg Asn Gly Ala Lys Trp Ile Asp Asp Leu Ser Cys Val Val Ala 
    130                 135                 140                 


Asp Glu Val His Leu Val Asn Asp Ala His Arg Gly Pro Thr Leu Glu 
145                 150                 155                 160 


Val Thr Leu Ala Lys Leu Arg Arg Val Asn Pro Asp Leu Gln Thr Val 
                165                 170                 175     


Ala Leu Ser Ala Thr Val Gly Asn Ala Gly Glu Met Ala Asp Trp Leu 
            180                 185                 190         


Asp Ala Thr Leu Val Asp Ser Thr Trp Arg Pro Ile Asp Leu Arg Lys 
        195                 200                 205             


Gly Val Leu Tyr Gly Gln Ala Leu His Phe Asp Asp Gly Thr Gln Gln 
    210                 215                 220                 


Glu Leu Ala Arg Gly Asn Glu Lys Glu Thr Ala Ala Leu Val Arg Asp 
225                 230                 235                 240 


Thr Leu Glu Asp Gly Gly Ser Ser Leu Val Phe Val Asn Ser Arg Arg 
                245                 250                 255     


Asn Ala Glu Ala Ala Ala Lys Arg Leu Ala Asp Val Thr Lys Thr His 
            260                 265                 270         


Leu Thr Asp Asp Glu Arg Arg Asp Leu Leu Asp Ile Ala Asp Gln Ile 
        275                 280                 285             


Arg Asp Val Ser Asp Thr Glu Thr Ser Asp Asp Leu Ala Thr Ala Ile 
    290                 295                 300                 


Glu Lys Gly Ala Ala Phe His His Ala Gly Leu Ala Ser Asp His Arg 
305                 310                 315                 320 


Ser Leu Val Glu Asp Ala Phe Arg Asp Lys Leu Ile Lys Val Ile Ser 
                325                 330                 335     


Ala Thr Pro Thr Leu Ala Ala Gly Val Asn Thr Pro Ser Arg Arg Val 
            340                 345                 350         


Ile Val Arg Asp Trp Arg Arg Tyr Asp Gly Asp Ile Gly Gly Met Gln 
        355                 360                 365             


Pro Leu Asp Val Leu Glu Val His Gln Met Phe Gly Arg Ala Gly Arg 
    370                 375                 380                 


Pro Gly Leu Asp Pro His Gly Glu Ala Val Leu Ile Ala Lys Ser His 
385                 390                 395                 400 


Asp Glu Leu Gln Glu Leu Phe Asp Gln Tyr Val Trp Ala Asp Pro Glu 
                405                 410                 415     


Pro Val His Ser Lys Leu Ala Ala Glu Pro Ala Leu Arg Thr His Ile 
            420                 425                 430         


Leu Ala Thr Val Ala Ser Gly Phe Ala Gly Thr Glu Glu Glu Leu Leu 
        435                 440                 445             


Asp Phe Leu Glu Arg Thr Leu Tyr Ala Thr Gln Thr Asp Glu Thr Gly 
    450                 455                 460                 


Arg Leu Glu Thr Val Thr Gln His Val Leu Asp Tyr Leu Asp Arg Asn 
465                 470                 475                 480 


Gly Phe Leu Glu Arg Asp Asp Arg Leu Arg Ala Thr Gly Leu Gly His 
                485                 490                 495     


Arg Val Ser Gln Leu Tyr Leu Asp Pro Met Ser Ala Ala Glu Ile Ile 
            500                 505                 510         


Asp Gly Leu Arg Asp Ala Asp Gly Lys Pro Thr Ala Leu Gly Leu Tyr 
        515                 520                 525             


His Leu Val Ser Arg Thr Pro Asp Met Tyr Gln Leu Tyr Leu Arg Ser 
    530                 535                 540                 


Gly Asp Arg Glu Arg Tyr Thr Glu Ile Ala Tyr Glu Arg Glu Pro Glu 
545                 550                 555                 560 


Phe Leu Gly His Met Pro Ser Glu Phe Glu Asp Asn Ala Phe Glu Asp 
                565                 570                 575     


Trp Leu Ser Ala Leu Lys Thr Ala Arg Leu Leu Glu Asp Trp Ala Ser 
            580                 585                 590         


Glu Leu Asp Glu Asp Arg Ile Thr Glu Arg Tyr Ala Ile Gly Pro Gly 
        595                 600                 605             


Asp Ile Arg Gly Lys Val Glu Thr Ala Gln Trp Leu Leu Asn Ala Ala 
    610                 615                 620                 


Glu Arg Leu Ala Ala Glu Leu Gln Arg Asp Asp Ala Glu Gly Ile Pro 
625                 630                 635                 640 


Ser Ala Thr Thr Thr Ala Val Arg Glu Ala Arg Lys Arg Val Glu Tyr 
                645                 650                 655     


Gly Val Glu Glu Glu Leu Leu Asp Leu Ala Gly Val Arg Asn Val Gly 
            660                 665                 670         


Arg Lys Arg Ala Arg Arg Leu Tyr Glu Ala Gly Ile Glu Ser Arg Ala 
        675                 680                 685             


Asp Leu Arg Glu Ala Asp Lys Ser Val Val Leu Gly Ala Leu Arg Gly 
    690                 695                 700                 


Arg Lys Lys Thr Ala Glu Asn Ile Leu Glu Asn Val Gly Arg Gln Asp 
705                 710                 715                 720 


Pro Ser Leu Asp Asp Val Glu Ala Asp Ala Glu Thr Ala Ala Thr Ser 
                725                 730                 735     


Ala Arg Ala Thr Asn Asp Gly Gly Gln Gln Ser Leu Gly Asp Phe Glu 
            740                 745                 750         


<210>  56
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Exemplary Hel308 motif

<400>  56

Gln Met Phe Gly Arg Ala Gly Arg 
1               5               


<210>  57
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Exemplary extended Hel308 motif

<400>  57

Gln Met Phe Gly Arg Ala Gly Arg Pro 
1               5                   


<210>  58
<211>  783
<212>  PRT
<213>  Halobacterium sp. NRC-1

<400>  58

Met Arg Val Ala Asp Val Pro Gly Leu Pro Gly Gly Val Ala Asp His 
1               5                   10                  15      


Phe Glu Gly Glu Gly Val Glu Glu Leu Tyr Pro Pro Gln Ala Glu Ala 
            20                  25                  30          


Val Glu Arg Gly Val Thr Glu Gly Ala Asn Leu Val Ala Ser Val Pro 
        35                  40                  45              


Thr Ala Ser Gly Lys Thr Leu Ile Ala Gln Leu Ala Met Leu Ser Ala 
    50                  55                  60                  


Ile Ala Glu Gly Gly Asp Ser Pro Thr Phe Ser Gly Asp Gly Thr Ala 
65                  70                  75                  80  


Leu Tyr Ile Val Pro Leu Arg Ala Leu Ala Gly Glu Lys Ala Gln Glu 
                85                  90                  95      


Phe Glu Ala Phe Glu Arg Phe Gly Leu Ser Val Gly Val Ser Thr Gly 
            100                 105                 110         


Asn Tyr Glu Arg Asp Gly Ala Arg Leu Ala Asp Asn Asp Ile Val Val 
        115                 120                 125             


Ala Thr Ser Glu Lys Val Asp Ser Leu Val Arg Asn Gly Ala Gly Trp 
    130                 135                 140                 


Ile Asp Asp Leu Ser Cys Val Val Ala Asp Glu Val His Leu Val Asp 
145                 150                 155                 160 


Asp Asp His Arg Gly Pro Thr Leu Glu Val Thr Leu Ala Lys Leu Arg 
                165                 170                 175     


Gln Gln Val Ala Asp Leu Gln Val Val Ala Leu Ser Ala Thr Val Gly 
            180                 185                 190         


Asn Ala Gly Glu Leu Ala Ala Trp Leu Asp Ala Glu Leu Val Asp Ser 
        195                 200                 205             


Asp Trp Arg Pro Ile Glu Leu Arg Thr Gly Val His Tyr Gly Gln Ser 
    210                 215                 220                 


Leu His Tyr Asp Asp Gly Thr Gln Ala Glu Leu Ser Val Gly Ser Gly 
225                 230                 235                 240 


Ser Gln Thr Ala Ala Val Val Ala Asp Thr Leu Ala Asp Asp Gly Ser 
                245                 250                 255     


Thr Leu Val Phe Val Asn Ser Arg Arg Asn Ala Glu Ala Ser Ala Arg 
            260                 265                 270         


Arg Leu Ala Asp Val Thr Gly Asn Ala Leu Ser Ser Ala Glu Arg Glu 
        275                 280                 285             


Arg Leu Ala Asp Ile Ala Ala Glu Ile Arg Gly Val Ser Asp Thr Glu 
    290                 295                 300                 


Thr Ser Asp Glu Leu Ala Asp Ala Val Ala Ser Gly Ala Ala Phe His 
305                 310                 315                 320 


His Ala Gly Leu Ala Arg Glu His Arg Glu Leu Val Glu Glu Ala Phe 
                325                 330                 335     


Arg Asp Arg Leu Val Lys Ala Val Ser Ala Thr Pro Thr Leu Ala Ala 
            340                 345                 350         


Gly Val Asn Thr Pro Ala Arg Arg Val Val Val Arg Asp Trp Gln Arg 
        355                 360                 365             


Tyr Asp Gly Thr Ala Gly Gly Met Gln Pro Leu Asp Val Leu Glu Val 
    370                 375                 380                 


His Gln Met Phe Gly Arg Ala Gly Arg Pro Gly Leu Asp Pro Tyr Gly 
385                 390                 395                 400 


Glu Ala Val Leu Leu Ala Asn Ser His Asp Glu Leu Glu Glu Leu Phe 
                405                 410                 415     


Asp Arg Tyr Val Tyr Ala Asp Pro Glu Pro Val Arg Ser Lys Leu Ala 
            420                 425                 430         


Ala Glu Pro Ala Leu Arg Thr His Val Leu Ala Ala Ile Ala Thr Gly 
        435                 440                 445             


Phe Thr Thr Thr Glu Asp Gly Leu His Glu Phe Leu Gly Gly Thr Leu 
    450                 455                 460                 


Tyr Ala Thr Gln Thr Asp Asp Thr Gly Arg Leu Arg Ser Val Thr Gly 
465                 470                 475                 480 


Asp Val Leu Arg Tyr Leu Asp Arg Asn Gly Phe Val Glu Arg Asp Gly 
                485                 490                 495     


Ala Ala Leu Arg Ala Thr Ala Thr Gly Gln Leu Val Ser Arg Leu Tyr 
            500                 505                 510         


Val Asp Pro Met Ser Ala Ala Thr Ile Ile Asp Gly Leu Arg Asp Ala 
        515                 520                 525             


Ala Arg Asp Ala Thr Glu Thr Asp Asp Glu Gly Ala Phe Arg Pro Ala 
    530                 535                 540                 


Ser Glu Leu Gly Asp Asp Ala Ala Leu Pro Ala Asp Ala Ser Val Glu 
545                 550                 555                 560 


Pro Thr Pro Leu Gly Leu Tyr His Leu Val Ser Arg Thr Pro Asp Met 
                565                 570                 575     


Tyr Glu Leu Tyr Leu Arg Ser Gly Asp Arg Glu Gln Tyr Thr Glu Val 
            580                 585                 590         


Ala Tyr Glu His Glu Asp Glu Leu Leu Gly Ala Thr Pro Arg Glu Glu 
        595                 600                 605             


Gln Ala Glu Phe Glu Asp Trp Leu Ser Ala Leu Lys Thr Ala Arg Leu 
    610                 615                 620                 


Met Ala Asp Trp Ala Ser Glu Leu Asp Glu Glu Arg Ile Ala Glu Arg 
625                 630                 635                 640 


Tyr Asp Val Gly Pro Gly Asp Ile Arg Gly Lys Val Glu Thr Ala Glu 
                645                 650                 655     


Trp Leu Leu Asn Ala Ala Glu Arg Leu Ala Gly Glu Leu Asp Val Glu 
            660                 665                 670         


Cys Gly Pro Ala Val Arg Glu Ala Arg Lys Arg Val Gln Tyr Gly Val 
        675                 680                 685             


Arg Glu Glu Leu Leu Gly Leu Ala Gly Val Arg Asn Val Gly Arg Lys 
    690                 695                 700                 


Arg Ala Arg Arg Leu Tyr Asn Ala Gly Val Glu Ser Arg Ala Asp Leu 
705                 710                 715                 720 


Arg Asn Ala Asp Lys Gly Val Val Leu Gly Ala Val Arg Gly Arg Ala 
                725                 730                 735     


Ala Thr Ala Glu Arg Ile Leu Glu Thr Val Gly His Pro Asp Pro Gly 
            740                 745                 750         


Met Asp Gly Val Ala Ala Asp Thr Asp Ala Ala Pro Glu Ser Gly Gly 
        755                 760                 765             


Glu Ala Gly Gly Asp Glu Gly Gln Ala Ser Leu Gly Asp Phe Ser 
    770                 775                 780             


<210>  59
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  RecD-like motif I


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa = G, S or A

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = any amino acid

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa = P, A, S or G

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa = T, A, V, S or C

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa = G or A

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa = K or R

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa = T or S

<400>  59

Xaa Xaa Xaa Gly Xaa Xaa Xaa Xaa 
1               5               


<210>  60
<211>  25
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Extended RecD-like motif I


<220>
<221>  MISC_FEATURE
<222>  (2)..(17)
<223>  Xaa = any amino acid

<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  Xaa = G, S or A

<220>
<221>  MISC_FEATURE
<222>  (19)..(19)
<223>  Xaa = any amino acid

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  Xaa = P, A, S or G

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  Xaa = T, A, V, S or C

<220>
<221>  MISC_FEATURE
<222>  (23)..(23)
<223>  Xaa = G or A

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Xaa = K or R

<220>
<221>  MISC_FEATURE
<222>  (25)..(25)
<223>  Xaa = T or S

<400>  60

Gln Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Gly Xaa Xaa Xaa Xaa 
            20                  25  


<210>  61
<211>  26
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Extended RecD-like motif I


<220>
<221>  MISC_FEATURE
<222>  (2)..(18)
<223>  Xaa = any amino acid

<220>
<221>  MISC_FEATURE
<222>  (19)..(19)
<223>  Xaa = G, S or A

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  Xaa = any amino acid

<220>
<221>  MISC_FEATURE
<222>  (21)..(21)
<223>  Xaa = P, A, S or G

<220>
<221>  MISC_FEATURE
<222>  (23)..(23)
<223>  Xaa = T, A, V, S or C

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Xaa = G or A

<220>
<221>  MISC_FEATURE
<222>  (25)..(25)
<223>  Xaa = K or A

<220>
<221>  MISC_FEATURE
<222>  (26)..(26)
<223>  Xaa = T or S

<400>  61

Gln Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Gly Xaa Xaa Xaa Xaa 
            20                  25      


<210>  62
<211>  27
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Extended RecD-like motif I


<220>
<221>  MISC_FEATURE
<222>  (2)..(19)
<223>  Xaa = any amino acid

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  Xaa = G, S or A

<220>
<221>  MISC_FEATURE
<222>  (21)..(21)
<223>  Xaa = any amino acid

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  Xaa = P, A, S or G

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Xaa = T, A, V, S or C

<220>
<221>  MISC_FEATURE
<222>  (25)..(25)
<223>  Xaa = G or A

<220>
<221>  MISC_FEATURE
<222>  (26)..(26)
<223>  Xaa = K or R

<220>
<221>  MISC_FEATURE
<222>  (27)..(27)
<223>  Xaa = T or S

<400>  62

Gln Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Gly Xaa Xaa Xaa Xaa 
            20                  25          


<210>  63
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  RecD motif I


<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa = T, V or C

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa = T or S

<400>  63

Gly Gly Pro Gly Xaa Gly Lys Xaa 
1               5               


<210>  64
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Preferred RecD motif I

<400>  64

Gly Gly Pro Gly Thr Gly Lys Thr 
1               5               


<210>  65
<211>  25
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Extended RecD motif I


<220>
<221>  MISC_FEATURE
<222>  (2)..(17)
<223>  Xaa = any amino acid

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  Xaa = T, V or C

<220>
<221>  MISC_FEATURE
<222>  (25)..(25)
<223>  Xaa = T or S

<400>  65

Gln Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Gly Gly Pro Gly Xaa Gly Lys Xaa 
            20                  25  


<210>  66
<211>  26
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Extended RecD motif I


<220>
<221>  MISC_FEATURE
<222>  (2)..(18)
<223>  Xaa = any amino acid

<220>
<221>  MISC_FEATURE
<222>  (23)..(23)
<223>  Xaa = T, V or C

<220>
<221>  MISC_FEATURE
<222>  (26)..(26)
<223>  Xaa = T or S

<400>  66

Gln Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Gly Gly Pro Gly Xaa Gly Lys Xaa 
            20                  25      


<210>  67
<211>  27
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Extended RecD motif I


<220>
<221>  MISC_FEATURE
<222>  (2)..(19)
<223>  Xaa = any amino acid

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Xaa = T, V or C

<220>
<221>  MISC_FEATURE
<222>  (27)..(27)
<223>  Xaa = T or S

<400>  67

Gln Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Gly Gly Pro Gly Xaa Gly Lys Xaa 
            20                  25          


<210>  68
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  RecD-like motif V


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa = Y, W or F

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = A, T, S, M, C or V

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa = any amino acid

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa = T, N or S

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa = A, T, G, S, V or I

<220>
<221>  MISC_FEATURE
<222>  (6)..(8)
<223>  Xaa = any amino acid

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa = G or S

<400>  68

Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Gln Xaa 
1               5                   10  


<210>  69
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  RecD motif V


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa = Y, W or F

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = A, M, C or V

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa = I, M or L

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa = T or S

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa = V or I

<400>  69

Xaa Xaa Xaa Xaa Xaa His Lys Ser Gln Gly 
1               5                   10  


<210>  70
<211>  13
<212>  PRT
<213>  Artificial sequence

<220>
<223>  MobF motif III


<220>
<221>  MISC_FEATURE
<222>  (2)..(3)
<223>  Xaa = any amino acid

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa = any amino acid except D, E, R and K

<220>
<221>  MISC_FEATURE
<222>  (6)..(10)
<223>  Xaa = any amino acid

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Xaa = any amino acid except D, E, R and K

<400>  70

His Xaa Xaa Xaa Arg Xaa Xaa Xaa Xaa Xaa His Xaa His 
1               5                   10              


<210>  71
<211>  14
<212>  PRT
<213>  Artificial sequence

<220>
<223>  MobF motif III


<220>
<221>  MISC_FEATURE
<222>  (2)..(3)
<223>  Xaa = any amino acid

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa = any amino acid except D, E, R and K

<220>
<221>  MISC_FEATURE
<222>  (6)..(11)
<223>  Xaa = any amino acid

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  Xaa = any amino acid except D, E, R and K

<400>  71

His Xaa Xaa Xaa Arg Xaa Xaa Xaa Xaa Xaa Xaa His Xaa His 
1               5                   10                  


<210>  72
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  MobF motif III


<220>
<221>  MISC_FEATURE
<222>  (2)..(3)
<223>  Xaa = any amino acid

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa = any amino acid except D, E, R and K

<220>
<221>  MISC_FEATURE
<222>  (6)..(12)
<223>  Xaa = any amino acid

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa = any amino acid except D, E, R and K

<400>  72

His Xaa Xaa Xaa Arg Xaa Xaa Xaa Xaa Xaa Xaa Xaa His Xaa His 
1               5                   10                  15  


<210>  73
<211>  16
<212>  PRT
<213>  Artificial sequence

<220>
<223>  MobF motif III


<220>
<221>  MISC_FEATURE
<222>  (2)..(3)
<223>  Xaa = any amino acid

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa = any amino acid except D, E, R and K

<220>
<221>  MISC_FEATURE
<222>  (6)..(13)
<223>  Xaa = any amino acid

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  Xaa = any amino acid except D, E, R and K

<400>  73

His Xaa Xaa Xaa Arg Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa His Xaa His 
1               5                   10                  15      


<210>  74
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  MobF motif III


<220>
<221>  MISC_FEATURE
<222>  (2)..(3)
<223>  Xaa = any amino acid

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa = any amino acid except D, E, R and K

<220>
<221>  MISC_FEATURE
<222>  (6)..(14)
<223>  Xaa = any amino acid

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa = any amino acid except D, E, R and K

<400>  74

His Xaa Xaa Xaa Arg Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa His Xaa 
1               5                   10                  15      


His 
    


<210>  75
<211>  18
<212>  PRT
<213>  Artificial sequence

<220>
<223>  MobF motif III


<220>
<221>  MISC_FEATURE
<222>  (2)..(3)
<223>  Xaa = any amino acid

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa = any amino acid except D, E, R and K

<220>
<221>  MISC_FEATURE
<222>  (6)..(15)
<223>  Xaa = any amino acid

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  Xaa = any amino acid except D, E, R and K

<400>  75

His Xaa Xaa Xaa Arg Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa His 
1               5                   10                  15      


Xaa His 
        


<210>  76
<211>  19
<212>  PRT
<213>  Artificial sequence

<220>
<223>  MobF motif III


<220>
<221>  MISC_FEATURE
<222>  (2)..(3)
<223>  Xaa = any amino acid

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa = any amino acid except D, E, R and K

<220>
<221>  MISC_FEATURE
<222>  (6)..(16)
<223>  Xaa = any amino acid

<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  Xaa = any amino acid except D, E, R and K

<400>  76

His Xaa Xaa Xaa Arg Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


His Xaa His 
            


<210>  77
<211>  20
<212>  PRT
<213>  Artificial sequence

<220>
<223>  MobF motif III


<220>
<221>  MISC_FEATURE
<222>  (2)..(3)
<223>  Xaa = any amino acid

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa = any amino acid except D, E, R and K

<220>
<221>  MISC_FEATURE
<222>  (6)..(17)
<223>  Xaa = any amino acid

<220>
<221>  MISC_FEATURE
<222>  (19)..(19)
<223>  Xaa = any amino acid

<400>  77

His Xaa Xaa Xaa Arg Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa His Xaa His 
            20  


<210>  78
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  MobQ motif III


<220>
<221>  MISC_FEATURE
<222>  (2)..(4)
<223>  Xaa = any amino acid except D, E, K and R

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa = D or E

<220>
<221>  MISC_FEATURE
<222>  (6)..(8)
<223>  Xaa = any amino acid except D, E, K and R

<220>
<221>  MISC_FEATURE
<222>  (10)..(15)
<223>  Xaa = any amino acid

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  Xaa = any amino acid except D, E, K and R

<400>  78

Gly Xaa Xaa Xaa Xaa Xaa Xaa Xaa His Xaa Xaa Xaa Xaa Xaa Xaa His 
1               5                   10                  15      


Xaa 
    


<210>  79
<211>  18
<212>  PRT
<213>  Artificial sequence

<220>
<223>  MobQ motif III


<220>
<221>  MISC_FEATURE
<222>  (2)..(4)
<223>  Xaa = any amino acid except D, E, K and R

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa = D or E

<220>
<221>  MISC_FEATURE
<222>  (6)..(8)
<223>  Xaa = any amino acid except D, E, K and R

<220>
<221>  MISC_FEATURE
<222>  (10)..(16)
<223>  Xaa = any amino acid

<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  Xaa = any amino acid except D, E, K and R

<400>  79

Gly Xaa Xaa Xaa Xaa Xaa Xaa Xaa His Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


His Xaa 
        


<210>  80
<211>  19
<212>  PRT
<213>  Artificial sequence

<220>
<223>  MobQ motif III


<220>
<221>  MISC_FEATURE
<222>  (2)..(4)
<223>  Xaa = any amino acid except D, E, K and R

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa = D or E

<220>
<221>  MISC_FEATURE
<222>  (6)..(8)
<223>  Xaa = any amino acid except D, E, K and R

<220>
<221>  MISC_FEATURE
<222>  (10)..(17)
<223>  Xaa = any amino acid

<220>
<221>  MISC_FEATURE
<222>  (19)..(19)
<223>  Xaa = any amino acid except D, E, K and R

<400>  80

Gly Xaa Xaa Xaa Xaa Xaa Xaa Xaa His Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa His Xaa 
            


<210>  81
<211>  20
<212>  PRT
<213>  Artificial sequence

<220>
<223>  MobQ motif III


<220>
<221>  MISC_FEATURE
<222>  (2)..(4)
<223>  Xaa = any amino acid except D, E, K and R

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa = D or E

<220>
<221>  MISC_FEATURE
<222>  (6)..(8)
<223>  Xaa = any amino acid except D, E, K and R

<220>
<221>  MISC_FEATURE
<222>  (10)..(18)
<223>  Xaa = any amino acid

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  Xaa = any amino acid except D, E, K and R

<400>  81

Gly Xaa Xaa Xaa Xaa Xaa Xaa Xaa His Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa His Xaa 
            20  


<210>  82
<211>  21
<212>  PRT
<213>  Artificial sequence

<220>
<223>  MobQ motif III


<220>
<221>  MISC_FEATURE
<222>  (2)..(4)
<223>  Xaa = any amino acid except D, E, K and R

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa = D or E

<220>
<221>  MISC_FEATURE
<222>  (6)..(8)
<223>  Xaa = any amino acid except D, E, K and R

<220>
<221>  MISC_FEATURE
<222>  (10)..(19)
<223>  Xaa = any amino acid

<220>
<221>  MISC_FEATURE
<222>  (21)..(21)
<223>  Xaa = any amino acid

<400>  82

Gly Xaa Xaa Xaa Xaa Xaa Xaa Xaa His Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa His Xaa 
            20      


<210>  83
<211>  22
<212>  PRT
<213>  Artificial sequence

<220>
<223>  MobQ motif III


<220>
<221>  MISC_FEATURE
<222>  (2)..(4)
<223>  Xaa = any amino acid except D, E, K and R

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa = D or E

<220>
<221>  MISC_FEATURE
<222>  (6)..(8)
<223>  Xaa = any amino acid except D, E, K and R

<220>
<221>  MISC_FEATURE
<222>  (10)..(20)
<223>  Xaa = any amino acid

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  Xaa = any amino acid except D, E, K and R

<400>  83

Gly Xaa Xaa Xaa Xaa Xaa Xaa Xaa His Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa His Xaa 
            20          


<210>  84
<211>  23
<212>  PRT
<213>  Artificial sequence

<220>
<223>  MobQ motif III


<220>
<221>  MISC_FEATURE
<222>  (2)..(4)
<223>  Xaa = any amino acid except D, E, K and R

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa = D or E

<220>
<221>  MISC_FEATURE
<222>  (6)..(8)
<223>  Xaa = any amino acid except D, E, K and R

<220>
<221>  MISC_FEATURE
<222>  (10)..(21)
<223>  Xaa = any amino acid

<220>
<221>  MISC_FEATURE
<222>  (23)..(23)
<223>  Xaa = any amino acid except D, E, K and R

<400>  84

Gly Xaa Xaa Xaa Xaa Xaa Xaa Xaa His Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa His Xaa 
            20              


<210>  85
<211>  1756
<212>  PRT
<213>  Escherichia coli

<400>  85

Met Met Ser Ile Ala Gln Val Arg Ser Ala Gly Ser Ala Gly Asn Tyr 
1               5                   10                  15      


Tyr Thr Asp Lys Asp Asn Tyr Tyr Val Leu Gly Ser Met Gly Glu Arg 
            20                  25                  30          


Trp Ala Gly Lys Gly Ala Glu Gln Leu Gly Leu Gln Gly Ser Val Asp 
        35                  40                  45              


Lys Asp Val Phe Thr Arg Leu Leu Glu Gly Arg Leu Pro Asp Gly Ala 
    50                  55                  60                  


Asp Leu Ser Arg Met Gln Asp Gly Ser Asn Lys His Arg Pro Gly Tyr 
65                  70                  75                  80  


Asp Leu Thr Phe Ser Ala Pro Lys Ser Val Ser Met Met Ala Met Leu 
                85                  90                  95      


Gly Gly Asp Lys Arg Leu Ile Asp Ala His Asn Gln Ala Val Asp Phe 
            100                 105                 110         


Ala Val Arg Gln Val Glu Ala Leu Ala Ser Thr Arg Val Met Thr Asp 
        115                 120                 125             


Gly Gln Ser Glu Thr Val Leu Thr Gly Asn Leu Val Met Ala Leu Phe 
    130                 135                 140                 


Asn His Asp Thr Ser Arg Asp Gln Glu Pro Gln Leu His Thr His Ala 
145                 150                 155                 160 


Val Val Ala Asn Val Thr Gln His Asn Gly Glu Trp Lys Thr Leu Ser 
                165                 170                 175     


Ser Asp Lys Val Gly Lys Thr Gly Phe Ile Glu Asn Val Tyr Ala Asn 
            180                 185                 190         


Gln Ile Ala Phe Gly Arg Leu Tyr Arg Glu Lys Leu Lys Glu Gln Val 
        195                 200                 205             


Glu Ala Leu Gly Tyr Glu Thr Glu Val Val Gly Lys His Gly Met Trp 
    210                 215                 220                 


Glu Met Pro Gly Val Pro Val Glu Ala Phe Ser Gly Arg Ser Gln Ala 
225                 230                 235                 240 


Ile Arg Glu Ala Val Gly Glu Asp Ala Ser Leu Lys Ser Arg Asp Val 
                245                 250                 255     


Ala Ala Leu Asp Thr Arg Lys Ser Lys Gln His Val Asp Pro Glu Ile 
            260                 265                 270         


Arg Met Ala Glu Trp Met Gln Thr Leu Lys Glu Thr Gly Phe Asp Ile 
        275                 280                 285             


Arg Ala Tyr Arg Asp Ala Ala Asp Gln Arg Thr Glu Ile Arg Thr Gln 
    290                 295                 300                 


Ala Pro Gly Pro Ala Ser Gln Asp Gly Pro Asp Val Gln Gln Ala Val 
305                 310                 315                 320 


Thr Gln Ala Ile Ala Gly Leu Ser Glu Arg Lys Val Gln Phe Thr Tyr 
                325                 330                 335     


Thr Asp Val Leu Ala Arg Thr Val Gly Ile Leu Pro Pro Glu Asn Gly 
            340                 345                 350         


Val Ile Glu Arg Ala Arg Ala Gly Ile Asp Glu Ala Ile Ser Arg Glu 
        355                 360                 365             


Gln Leu Ile Pro Leu Asp Arg Glu Lys Gly Leu Phe Thr Ser Gly Ile 
    370                 375                 380                 


His Val Leu Asp Glu Leu Ser Val Arg Ala Leu Ser Arg Asp Ile Met 
385                 390                 395                 400 


Lys Gln Asn Arg Val Thr Val His Pro Glu Lys Ser Val Pro Arg Thr 
                405                 410                 415     


Ala Gly Tyr Ser Asp Ala Val Ser Val Leu Ala Gln Asp Arg Pro Ser 
            420                 425                 430         


Leu Ala Ile Val Ser Gly Gln Gly Gly Ala Ala Gly Gln Arg Glu Arg 
        435                 440                 445             


Val Ala Glu Leu Val Met Met Ala Arg Glu Gln Gly Arg Glu Val Gln 
    450                 455                 460                 


Ile Ile Ala Ala Asp Arg Arg Ser Gln Met Asn Leu Lys Gln Asp Glu 
465                 470                 475                 480 


Arg Leu Ser Gly Glu Leu Ile Thr Gly Arg Arg Gln Leu Leu Glu Gly 
                485                 490                 495     


Met Ala Phe Thr Pro Gly Ser Thr Val Ile Val Asp Gln Gly Glu Lys 
            500                 505                 510         


Leu Ser Leu Lys Glu Thr Leu Thr Leu Leu Asp Gly Ala Ala Arg His 
        515                 520                 525             


Asn Val Gln Val Leu Ile Thr Asp Ser Gly Gln Arg Thr Gly Thr Gly 
    530                 535                 540                 


Ser Ala Leu Met Ala Met Lys Asp Ala Gly Val Asn Thr Tyr Arg Trp 
545                 550                 555                 560 


Gln Gly Gly Glu Gln Arg Pro Ala Thr Ile Ile Ser Glu Pro Asp Arg 
                565                 570                 575     


Asn Val Arg Tyr Ala Arg Leu Ala Gly Asp Phe Ala Ala Ser Val Lys 
            580                 585                 590         


Ala Gly Glu Glu Ser Val Ala Gln Val Ser Gly Val Arg Glu Gln Ala 
        595                 600                 605             


Ile Leu Thr Gln Ala Ile Arg Ser Glu Leu Lys Thr Gln Gly Val Leu 
    610                 615                 620                 


Gly His Pro Glu Val Thr Met Thr Ala Leu Ser Pro Val Trp Leu Asp 
625                 630                 635                 640 


Ser Arg Ser Arg Tyr Leu Arg Asp Met Tyr Arg Pro Gly Met Val Met 
                645                 650                 655     


Glu Gln Trp Asn Pro Glu Thr Arg Ser His Asp Arg Tyr Val Ile Asp 
            660                 665                 670         


Arg Val Thr Ala Gln Ser His Ser Leu Thr Leu Arg Asp Ala Gln Gly 
        675                 680                 685             


Glu Thr Gln Val Val Arg Ile Ser Ser Leu Asp Ser Ser Trp Ser Leu 
    690                 695                 700                 


Phe Arg Pro Glu Lys Met Pro Val Ala Asp Gly Glu Arg Leu Arg Val 
705                 710                 715                 720 


Thr Gly Lys Ile Pro Gly Leu Arg Val Ser Gly Gly Asp Arg Leu Gln 
                725                 730                 735     


Val Ala Ser Val Ser Glu Asp Ala Met Thr Val Val Val Pro Gly Arg 
            740                 745                 750         


Ala Glu Pro Ala Ser Leu Pro Val Ser Asp Ser Pro Phe Thr Ala Leu 
        755                 760                 765             


Lys Leu Glu Asn Gly Trp Val Glu Thr Pro Gly His Ser Val Ser Asp 
    770                 775                 780                 


Ser Ala Thr Val Phe Ala Ser Val Thr Gln Met Ala Met Asp Asn Ala 
785                 790                 795                 800 


Thr Leu Asn Gly Leu Ala Arg Ser Gly Arg Asp Val Arg Leu Tyr Ser 
                805                 810                 815     


Ser Leu Asp Glu Thr Arg Thr Ala Glu Lys Leu Ala Arg His Pro Ser 
            820                 825                 830         


Phe Thr Val Val Ser Glu Gln Ile Lys Ala Arg Ala Gly Glu Thr Leu 
        835                 840                 845             


Leu Glu Thr Ala Ile Ser Leu Gln Lys Ala Gly Leu His Thr Pro Ala 
    850                 855                 860                 


Gln Gln Ala Ile His Leu Ala Leu Pro Val Leu Glu Ser Lys Asn Leu 
865                 870                 875                 880 


Ala Phe Ser Met Val Asp Leu Leu Thr Glu Ala Lys Ser Phe Ala Ala 
                885                 890                 895     


Glu Gly Thr Gly Phe Thr Glu Leu Gly Gly Glu Ile Asn Ala Gln Ile 
            900                 905                 910         


Lys Arg Gly Asp Leu Leu Tyr Val Asp Val Ala Lys Gly Tyr Gly Thr 
        915                 920                 925             


Gly Leu Leu Val Ser Arg Ala Ser Tyr Glu Ala Glu Lys Ser Ile Leu 
    930                 935                 940                 


Arg His Ile Leu Glu Gly Lys Glu Ala Val Thr Pro Leu Met Glu Arg 
945                 950                 955                 960 


Val Pro Gly Glu Leu Met Glu Thr Leu Thr Ser Gly Gln Arg Ala Ala 
                965                 970                 975     


Thr Arg Met Ile Leu Glu Thr Ser Asp Arg Phe Thr Val Val Gln Gly 
            980                 985                 990         


Tyr Ala Gly Val Gly Lys Thr Thr  Gln Phe Arg Ala Val  Met Ser Ala 
        995                 1000                 1005             


Val Asn  Met Leu Pro Ala Ser  Glu Arg Pro Arg Val  Val Gly Leu 
    1010                 1015                 1020             


Gly Pro  Thr His Arg Ala Val  Gly Glu Met Arg Ser  Ala Gly Val 
    1025                 1030                 1035             


Asp Ala  Gln Thr Leu Ala Ser  Phe Leu His Asp Thr  Gln Leu Gln 
    1040                 1045                 1050             


Gln Arg  Ser Gly Glu Thr Pro  Asp Phe Ser Asn Thr  Leu Phe Leu 
    1055                 1060                 1065             


Leu Asp  Glu Ser Ser Met Val  Gly Asn Thr Glu Met  Ala Arg Ala 
    1070                 1075                 1080             


Tyr Ala  Leu Ile Ala Ala Gly  Gly Gly Arg Ala Val  Ala Ser Gly 
    1085                 1090                 1095             


Asp Thr  Asp Gln Leu Gln Ala  Ile Ala Pro Gly Gln  Ser Phe Arg 
    1100                 1105                 1110             


Leu Gln  Gln Thr Arg Ser Ala  Ala Asp Val Val Ile  Met Lys Glu 
    1115                 1120                 1125             


Ile Val  Arg Gln Thr Pro Glu  Leu Arg Glu Ala Val  Tyr Ser Leu 
    1130                 1135                 1140             


Ile Asn  Arg Asp Val Glu Arg  Ala Leu Ser Gly Leu  Glu Ser Val 
    1145                 1150                 1155             


Lys Pro  Ser Gln Val Pro Arg  Leu Glu Gly Ala Trp  Ala Pro Glu 
    1160                 1165                 1170             


His Ser  Val Thr Glu Phe Ser  His Ser Gln Glu Ala  Lys Leu Ala 
    1175                 1180                 1185             


Glu Ala  Gln Gln Lys Ala Met  Leu Lys Gly Glu Ala  Phe Pro Asp 
    1190                 1195                 1200             


Ile Pro  Met Thr Leu Tyr Glu  Ala Ile Val Arg Asp  Tyr Thr Gly 
    1205                 1210                 1215             


Arg Thr  Pro Glu Ala Arg Glu  Gln Thr Leu Ile Val  Thr His Leu 
    1220                 1225                 1230             


Asn Glu  Asp Arg Arg Val Leu  Asn Ser Met Ile His  Asp Ala Arg 
    1235                 1240                 1245             


Glu Lys  Ala Gly Glu Leu Gly  Lys Glu Gln Val Met  Val Pro Val 
    1250                 1255                 1260             


Leu Asn  Thr Ala Asn Ile Arg  Asp Gly Glu Leu Arg  Arg Leu Ser 
    1265                 1270                 1275             


Thr Trp  Glu Lys Asn Pro Asp  Ala Leu Ala Leu Val  Asp Asn Val 
    1280                 1285                 1290             


Tyr His  Arg Ile Ala Gly Ile  Ser Lys Asp Asp Gly  Leu Ile Thr 
    1295                 1300                 1305             


Leu Gln  Asp Ala Glu Gly Asn  Thr Arg Leu Ile Ser  Pro Arg Glu 
    1310                 1315                 1320             


Ala Val  Ala Glu Gly Val Thr  Leu Tyr Thr Pro Asp  Lys Ile Arg 
    1325                 1330                 1335             


Val Gly  Thr Gly Asp Arg Met  Arg Phe Thr Lys Ser  Asp Arg Glu 
    1340                 1345                 1350             


Arg Gly  Tyr Val Ala Asn Ser  Val Trp Thr Val Thr  Ala Val Ser 
    1355                 1360                 1365             


Gly Asp  Ser Val Thr Leu Ser  Asp Gly Gln Gln Thr  Arg Val Ile 
    1370                 1375                 1380             


Arg Pro  Gly Gln Glu Arg Ala  Glu Gln His Ile Asp  Leu Ala Tyr 
    1385                 1390                 1395             


Ala Ile  Thr Ala His Gly Ala  Gln Gly Ala Ser Glu  Thr Phe Ala 
    1400                 1405                 1410             


Ile Ala  Leu Glu Gly Thr Glu  Gly Asn Arg Lys Leu  Met Ala Gly 
    1415                 1420                 1425             


Phe Glu  Ser Ala Tyr Val Ala  Leu Ser Arg Met Lys  Gln His Val 
    1430                 1435                 1440             


Gln Val  Tyr Thr Asp Asn Arg  Gln Gly Trp Thr Asp  Ala Ile Asn 
    1445                 1450                 1455             


Asn Ala  Val Gln Lys Gly Thr  Ala His Asp Val Leu  Glu Pro Lys 
    1460                 1465                 1470             


Pro Asp  Arg Glu Val Met Asn  Ala Gln Arg Leu Phe  Ser Thr Ala 
    1475                 1480                 1485             


Arg Glu  Leu Arg Asp Val Ala  Ala Gly Arg Ala Val  Leu Arg Gln 
    1490                 1495                 1500             


Ala Gly  Leu Ala Gly Gly Asp  Ser Pro Ala Arg Phe  Ile Ala Pro 
    1505                 1510                 1515             


Gly Arg  Lys Tyr Pro Gln Pro  Tyr Val Ala Leu Pro  Ala Phe Asp 
    1520                 1525                 1530             


Arg Asn  Gly Lys Ser Ala Gly  Ile Trp Leu Asn Pro  Leu Thr Thr 
    1535                 1540                 1545             


Asp Asp  Gly Asn Gly Leu Arg  Gly Phe Ser Gly Glu  Gly Arg Val 
    1550                 1555                 1560             


Lys Gly  Ser Gly Asp Ala Gln  Phe Val Ala Leu Gln  Gly Ser Arg 
    1565                 1570                 1575             


Asn Gly  Glu Ser Leu Leu Ala  Asp Asn Met Gln Asp  Gly Val Arg 
    1580                 1585                 1590             


Ile Ala  Arg Asp Asn Pro Asp  Ser Gly Val Val Val  Arg Ile Ala 
    1595                 1600                 1605             


Gly Glu  Gly Arg Pro Trp Asn  Pro Gly Ala Ile Thr  Gly Gly Arg 
    1610                 1615                 1620             


Val Trp  Gly Asp Ile Pro Asp  Asn Ser Val Gln Pro  Gly Ala Gly 
    1625                 1630                 1635             


Asn Gly  Glu Pro Val Thr Ala  Glu Val Leu Ala Gln  Arg Gln Ala 
    1640                 1645                 1650             


Glu Glu  Ala Ile Arg Arg Glu  Thr Glu Arg Arg Ala  Asp Glu Ile 
    1655                 1660                 1665             


Val Arg  Lys Met Ala Glu Asn  Lys Pro Asp Leu Pro  Asp Gly Lys 
    1670                 1675                 1680             


Thr Glu  Leu Ala Val Arg Asp  Ile Ala Gly Gln Glu  Arg Asp Arg 
    1685                 1690                 1695             


Ser Ala  Ile Ser Glu Arg Glu  Thr Ala Leu Pro Glu  Ser Val Leu 
    1700                 1705                 1710             


Arg Glu  Ser Gln Arg Glu Arg  Glu Ala Val Arg Glu  Val Ala Arg 
    1715                 1720                 1725             


Glu Asn  Leu Leu Gln Glu Arg  Leu Gln Gln Met Glu  Arg Asp Met 
    1730                 1735                 1740             


Val Arg  Asp Leu Gln Lys Glu  Lys Thr Leu Gly Gly  Asp 
    1745                 1750                 1755     


<210>  86
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  RecD-like motif I of TraI Eco

<400>  86

Gly Tyr Ala Gly Val Gly Lys Thr 
1               5               


<210>  87
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  RecD-like motif V of TraI Eco

<400>  87

Tyr Ala Ile Thr Ala His Gly Ala Gln Gly 
1               5                   10  


<210>  88
<211>  14
<212>  PRT
<213>  Artificial sequence

<220>
<223>  MobF  motif III of TraI Eco

<400>  88

His Asp Thr Ser Arg Asp Gln Glu Pro Gln Leu His Thr His 
1               5                   10                  


<210>  89
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  XPD motif V


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Any amino acid except D, E, K or R.  Preferably not charged or H.
       More preferably V, L, I, S or Y.

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Any amino acid except D, E, K or R.  Preferably not charged or H.

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Any amino acid.

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Any amino acid.  Preferably K, R or T.

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Any amino acid except D, E, K or R.  Preferably not charged or H.
       More preferably V, L, I, N or F.

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Any amino acid except D, E, K or R.  Preferably not charged or H.
       More preferably S or A.

<400>  89

Xaa Xaa Xaa Gly Xaa Xaa Xaa Glu Gly 
1               5                   


<210>  90
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  XPD motif VI


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Any amino acid

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Any amino acid except D, E, K, R.  Typically G, P, A, V, L, I, M,
       C, F, Y, W, H, Q, N, S or T.  Preferably not charged.  Preferably
       not H.  More preferably V, A, L, I or M.

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Any amino acid except D, E, K, R.  Typically G, P, A, V, L, I, M,
       C, F, Y, W, H, Q, N, S or T.  Preferably not charged.  Preferably
       not H.  More preferably V, A, L, I, M or C.

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Any amino acid except D, E, K, R.  Typically G, P, A, V, L, I, M,
       C, F, Y, W, H, Q, N, S or T.  Preferably not charged.  Preferably
       not H.  More preferably I, H, L, F, M or V.

<220>
<221>  MISC_FEATURE
<222>  (9)..(11)
<223>  Any amino acid.

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  D or E

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  Any amino acid.

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Any amino acid.  Preferably G, A, S or C

<220>
<221>  MISC_FEATURE
<222>  (15)..(16)
<223>  Any amino acid.

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  Any amino acid. Preferably F, V, L, I, M, A, W or Y

<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  Any amino acid. Preferably L, F, Y, M, I or V.

<220>
<221>  MISC_FEATURE
<222>  (19)..(19)
<223>  Any amino acid. Preferably A, C, V, L, I, M or S.

<400>  90

Gln Xaa Xaa Gly Arg Xaa Xaa Arg Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Asp Asn Arg 
            20          


<210>  91
<211>  726
<212>  PRT
<213>  Methanococcoides burtonii

<400>  91

Met Ser Asp Lys Pro Ala Phe Met Lys Tyr Phe Thr Gln Ser Ser Cys 
1               5                   10                  15      


Tyr Pro Asn Gln Gln Glu Ala Met Asp Arg Ile His Ser Ala Leu Met 
            20                  25                  30          


Gln Gln Gln Leu Val Leu Phe Glu Gly Ala Cys Gly Thr Gly Lys Thr 
        35                  40                  45              


Leu Ser Ala Leu Val Pro Ala Leu His Val Gly Lys Met Leu Gly Lys 
    50                  55                  60                  


Thr Val Ile Ile Ala Thr Asn Val His Gln Gln Met Val Gln Phe Ile 
65                  70                  75                  80  


Asn Glu Ala Arg Asp Ile Lys Lys Val Gln Asp Val Lys Val Ala Val 
                85                  90                  95      


Ile Lys Gly Lys Thr Ala Met Cys Pro Gln Glu Ala Asp Tyr Glu Glu 
            100                 105                 110         


Cys Ser Val Lys Arg Glu Asn Thr Phe Glu Leu Met Glu Thr Glu Arg 
        115                 120                 125             


Glu Ile Tyr Leu Lys Arg Gln Glu Leu Asn Ser Ala Arg Asp Ser Tyr 
    130                 135                 140                 


Lys Lys Ser His Asp Pro Ala Phe Val Thr Leu Arg Asp Glu Leu Ser 
145                 150                 155                 160 


Lys Glu Ile Asp Ala Val Glu Glu Lys Ala Arg Gly Leu Arg Asp Arg 
                165                 170                 175     


Ala Cys Asn Asp Leu Tyr Glu Val Leu Arg Ser Asp Ser Glu Lys Phe 
            180                 185                 190         


Arg Glu Trp Leu Tyr Lys Glu Val Arg Ser Pro Glu Glu Ile Asn Asp 
        195                 200                 205             


His Ala Ile Lys Asp Gly Met Cys Gly Tyr Glu Leu Val Lys Arg Glu 
    210                 215                 220                 


Leu Lys His Ala Asp Leu Leu Ile Cys Asn Tyr His His Val Leu Asn 
225                 230                 235                 240 


Pro Asp Ile Phe Ser Thr Val Leu Gly Trp Ile Glu Lys Glu Pro Gln 
                245                 250                 255     


Glu Thr Ile Val Ile Phe Asp Glu Ala His Asn Leu Glu Ser Ala Ala 
            260                 265                 270         


Arg Ser His Ser Ser Leu Ser Leu Thr Glu His Ser Ile Glu Lys Ala 
        275                 280                 285             


Ile Thr Glu Leu Glu Ala Asn Leu Asp Leu Leu Ala Asp Asp Asn Ile 
    290                 295                 300                 


His Asn Leu Phe Asn Ile Phe Leu Glu Val Ile Ser Asp Thr Tyr Asn 
305                 310                 315                 320 


Ser Arg Phe Lys Phe Gly Glu Arg Glu Arg Val Arg Lys Asn Trp Tyr 
                325                 330                 335     


Asp Ile Arg Ile Ser Asp Pro Tyr Glu Arg Asn Asp Ile Val Arg Gly 
            340                 345                 350         


Lys Phe Leu Arg Gln Ala Lys Gly Asp Phe Gly Glu Lys Asp Asp Ile 
        355                 360                 365             


Gln Ile Leu Leu Ser Glu Ala Ser Glu Leu Gly Ala Lys Leu Asp Glu 
    370                 375                 380                 


Thr Tyr Arg Asp Gln Tyr Lys Lys Gly Leu Ser Ser Val Met Lys Arg 
385                 390                 395                 400 


Ser His Ile Arg Tyr Val Ala Asp Phe Met Ser Ala Tyr Ile Glu Leu 
                405                 410                 415     


Ser His Asn Leu Asn Tyr Tyr Pro Ile Leu Asn Val Arg Arg Asp Met 
            420                 425                 430         


Asn Asp Glu Ile Tyr Gly Arg Val Glu Leu Phe Thr Cys Ile Pro Lys 
        435                 440                 445             


Asn Val Thr Glu Pro Leu Phe Asn Ser Leu Phe Ser Val Ile Leu Met 
    450                 455                 460                 


Ser Ala Thr Leu His Pro Phe Glu Met Val Lys Lys Thr Leu Gly Ile 
465                 470                 475                 480 


Thr Arg Asp Thr Cys Glu Met Ser Tyr Gly Thr Ser Phe Pro Glu Glu 
                485                 490                 495     


Lys Arg Leu Ser Ile Ala Val Ser Ile Pro Pro Leu Phe Ala Lys Asn 
            500                 505                 510         


Arg Asp Asp Arg His Val Thr Glu Leu Leu Glu Gln Val Leu Leu Asp 
        515                 520                 525             


Ser Ile Glu Asn Ser Lys Gly Asn Val Ile Leu Phe Phe Gln Ser Ala 
    530                 535                 540                 


Phe Glu Ala Lys Arg Tyr Tyr Ser Lys Ile Glu Pro Leu Val Asn Val 
545                 550                 555                 560 


Pro Val Phe Leu Asp Glu Val Gly Ile Ser Ser Gln Asp Val Arg Glu 
                565                 570                 575     


Glu Phe Phe Ser Ile Gly Glu Glu Asn Gly Lys Ala Val Leu Leu Ser 
            580                 585                 590         


Tyr Leu Trp Gly Thr Leu Ser Glu Gly Ile Asp Tyr Arg Asp Gly Arg 
        595                 600                 605             


Gly Arg Thr Val Ile Ile Ile Gly Val Gly Tyr Pro Ala Leu Asn Asp 
    610                 615                 620                 


Arg Met Asn Ala Val Glu Ser Ala Tyr Asp His Val Phe Gly Tyr Gly 
625                 630                 635                 640 


Ala Gly Trp Glu Phe Ala Ile Gln Val Pro Thr Ile Arg Lys Ile Arg 
                645                 650                 655     


Gln Ala Met Gly Arg Val Val Arg Ser Pro Thr Asp Tyr Gly Ala Arg 
            660                 665                 670         


Ile Leu Leu Asp Gly Arg Phe Leu Thr Asp Ser Lys Lys Arg Phe Gly 
        675                 680                 685             


Lys Phe Ser Val Phe Glu Val Phe Pro Pro Ala Glu Arg Ser Glu Phe 
    690                 695                 700                 


Val Asp Val Asp Pro Glu Lys Val Lys Tyr Ser Leu Met Asn Phe Phe 
705                 710                 715                 720 


Met Asp Asn Asp Glu Gln 
                725     


<210>  92
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Motif V

<400>  92

Tyr Leu Trp Gly Thr Leu Ser Glu Gly 
1               5                   


<210>  93
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Motif VI

<400>  93

Gln Ala Met Gly Arg Val Val Arg Ser Pro Thr Asp Tyr Gly Ala Arg 
1               5                   10                  15      


Ile Leu Leu Asp Gly Arg 
            20          


<210>  94
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Double stranded portion of MuA substrate

<400>  94
gttttcgcat ttatcgtgaa acgctttcgc gtttttcgtg cgccgcttca                  50


<210>  95
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Double stranded portion of MuA substrate with U at 3' end


<220>
<221>  misc_feature
<222>  (50)..(50)
<223>  n = U

<400>  95
caaaagcgta aatagcactt tgcgaaagcg caaaaagcac gcggcgaagn                  50


<210>  96
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Overhang strand of double stranded MuA substrate


<220>
<221>  misc_feature
<222>  (50)..(50)
<223>  n = U

<400>  96
caaaagcgta aatagcactt tgcgaaagcg caaaaagcac gcggcgaagn ctag             54


<210>  97
<211>  439
<212>  PRT
<213>  Enterobacteria phage T4

<400>  97

Met Thr Phe Asp Asp Leu Thr Glu Gly Gln Lys Asn Ala Phe Asn Ile 
1               5                   10                  15      


Val Met Lys Ala Ile Lys Glu Lys Lys His His Val Thr Ile Asn Gly 
            20                  25                  30          


Pro Ala Gly Thr Gly Lys Thr Thr Leu Thr Lys Phe Ile Ile Glu Ala 
        35                  40                  45              


Leu Ile Ser Thr Gly Glu Thr Gly Ile Ile Leu Ala Ala Pro Thr His 
    50                  55                  60                  


Ala Ala Lys Lys Ile Leu Ser Lys Leu Ser Gly Lys Glu Ala Ser Thr 
65                  70                  75                  80  


Ile His Ser Ile Leu Lys Ile Asn Pro Val Thr Tyr Glu Glu Asn Val 
                85                  90                  95      


Leu Phe Glu Gln Lys Glu Val Pro Asp Leu Ala Lys Cys Arg Val Leu 
            100                 105                 110         


Ile Cys Asp Glu Val Ser Met Tyr Asp Arg Lys Leu Phe Lys Ile Leu 
        115                 120                 125             


Leu Ser Thr Ile Pro Pro Trp Cys Thr Ile Ile Gly Ile Gly Asp Asn 
    130                 135                 140                 


Lys Gln Ile Arg Pro Val Asp Pro Gly Glu Asn Thr Ala Tyr Ile Ser 
145                 150                 155                 160 


Pro Phe Phe Thr His Lys Asp Phe Tyr Gln Cys Glu Leu Thr Glu Val 
                165                 170                 175     


Lys Arg Ser Asn Ala Pro Ile Ile Asp Val Ala Thr Asp Val Arg Asn 
            180                 185                 190         


Gly Lys Trp Ile Tyr Asp Lys Val Val Asp Gly His Gly Val Arg Gly 
        195                 200                 205             


Phe Thr Gly Asp Thr Ala Leu Arg Asp Phe Met Val Asn Tyr Phe Ser 
    210                 215                 220                 


Ile Val Lys Ser Leu Asp Asp Leu Phe Glu Asn Arg Val Met Ala Phe 
225                 230                 235                 240 


Thr Asn Lys Ser Val Asp Lys Leu Asn Ser Ile Ile Arg Lys Lys Ile 
                245                 250                 255     


Phe Glu Thr Asp Lys Asp Phe Ile Val Gly Glu Ile Ile Val Met Gln 
            260                 265                 270         


Glu Pro Leu Phe Lys Thr Tyr Lys Ile Asp Gly Lys Pro Val Ser Glu 
        275                 280                 285             


Ile Ile Phe Asn Asn Gly Gln Leu Val Arg Ile Ile Glu Ala Glu Tyr 
    290                 295                 300                 


Thr Ser Thr Phe Val Lys Ala Arg Gly Val Pro Gly Glu Tyr Leu Ile 
305                 310                 315                 320 


Arg His Trp Asp Leu Thr Val Glu Thr Tyr Gly Asp Asp Glu Tyr Tyr 
                325                 330                 335     


Arg Glu Lys Ile Lys Ile Ile Ser Ser Asp Glu Glu Leu Tyr Lys Phe 
            340                 345                 350         


Asn Leu Phe Leu Gly Lys Thr Ala Glu Thr Tyr Lys Asn Trp Asn Lys 
        355                 360                 365             


Gly Gly Lys Ala Pro Trp Ser Asp Phe Trp Asp Ala Lys Ser Gln Phe 
    370                 375                 380                 


Ser Lys Val Lys Ala Leu Pro Ala Ser Thr Phe His Lys Ala Gln Gly 
385                 390                 395                 400 


Met Ser Val Asp Arg Ala Phe Ile Tyr Thr Pro Cys Ile His Tyr Ala 
                405                 410                 415     


Asp Val Glu Leu Ala Gln Gln Leu Leu Tyr Val Gly Val Thr Arg Gly 
            420                 425                 430         


Arg Tyr Asp Val Phe Tyr Val 
        435                 


<210>  98
<211>  678
<212>  PRT
<213>  Rhodothermus marinus

<400>  98

Met Glu Glu Leu Ser Asn Glu Gln Gln Arg Val Leu Asp His Val Leu 
1               5                   10                  15      


Ala Trp Leu Glu Arg Asn Asp Ala Pro Pro Ile Phe Ile Leu Thr Gly 
            20                  25                  30          


Ser Ala Gly Thr Gly Lys Thr Leu Leu Ile Arg His Leu Val Arg Ala 
        35                  40                  45              


Leu Gln Asp Arg Arg Ile His Tyr Ala Leu Ala Ala Pro Thr Gly Arg 
    50                  55                  60                  


Ala Ala Arg Ile Leu Ser Glu Arg Thr Gly Asp His Ala Arg Thr Leu 
65                  70                  75                  80  


His Ser Leu Ile Tyr Ile Phe Asp Arg Tyr Gln Leu Val Glu Glu Ala 
                85                  90                  95      


Asp Arg Gln Thr Asp Glu Pro Leu Ser Leu Gln Leu His Phe Ala Leu 
            100                 105                 110         


Arg Ser Ala Glu His Asp Ala Arg Leu Ile Ile Val Asp Glu Ala Ser 
        115                 120                 125             


Met Val Ser Asp Thr Ala Gly Glu Glu Glu Leu Tyr Arg Phe Gly Ser 
    130                 135                 140                 


Gly Arg Leu Leu Asn Asp Leu Leu Thr Phe Ala Arg Leu Ile Pro Lys 
145                 150                 155                 160 


Arg Asp Arg Pro Pro Thr Thr Arg Leu Leu Phe Val Gly Asp Pro Ala 
                165                 170                 175     


Gln Leu Pro Pro Val Gly Gln Ser Val Ser Pro Ala Leu Ser Ala Gln 
            180                 185                 190         


Tyr Leu Arg Asp Thr Phe Gly Leu Ser Ala Glu Thr Ala His Leu Arg 
        195                 200                 205             


Ser Val Tyr Arg Gln Arg Lys Gly His Pro Ile Leu Glu Thr Ala Thr 
    210                 215                 220                 


Ala Leu Arg Asn Ala Leu Glu Lys Gly His Tyr His Thr Phe Arg Leu 
225                 230                 235                 240 


Pro Glu Gln Pro Pro Asp Leu Arg Pro Val Gly Leu Glu Glu Ala Ile 
                245                 250                 255     


Glu Thr Thr Ala Thr Asp Phe Arg Arg Gln Asn Pro Ser Val Leu Leu 
            260                 265                 270         


Cys Arg Thr Asn Ala Leu Ala Arg Lys Leu Asn Ala Ala Val Arg Ala 
        275                 280                 285             


Arg Leu Trp Gly Arg Glu Gly Leu Pro Pro Gln Pro Gly Asp Leu Leu 
    290                 295                 300                 


Leu Val Asn Arg Asn Ala Pro Leu His Gly Leu Phe Asn Gly Asp Leu 
305                 310                 315                 320 


Val Leu Val Glu Thr Val Gly Pro Leu Glu His Arg Arg Val Gly Arg 
                325                 330                 335     


Arg Gly Arg Pro Pro Val Asp Leu Tyr Phe Arg Asp Val Glu Leu Leu 
            340                 345                 350         


Tyr Pro His Glu Lys Pro Arg Asn Arg Ile Arg Cys Lys Leu Leu Glu 
        355                 360                 365             


Asn Leu Leu Glu Ser Pro Asp Gly Gln Leu Ser Pro Asp Ile Ile Gln 
    370                 375                 380                 


Ala Leu Leu Ile Asp Phe Tyr Arg Arg His Pro Ser Leu Lys His Gly 
385                 390                 395                 400 


Ser Ser Glu Phe Arg Leu Met Leu Ala Asn Asp Ala Tyr Phe Asn Ala 
                405                 410                 415     


Leu His Val Arg Tyr Gly Tyr Ala Met Thr Val His Lys Ala Gln Gly 
            420                 425                 430         


Gly Glu Trp Lys Arg Ala Thr Val Val Phe Asn Asp Trp Arg His Phe 
        435                 440                 445             


Arg His Ala Glu Phe Phe Arg Trp Ala Tyr Thr Ala Ile Thr Arg Ala 
    450                 455                 460                 


Arg Glu Glu Leu Leu Thr Ile Gly Ala Pro Ser Phe Glu Ala Leu Ser 
465                 470                 475                 480 


Asp Met Arg Trp Gln Pro Ala Pro Ser Val Pro Ala Pro Glu Gln Ala 
                485                 490                 495     


Ala Glu Asn Ala Thr Arg Phe Pro Leu Lys Ala Leu Glu Thr Tyr His 
            500                 505                 510         


Gln Arg Leu Ser Glu Ala Leu Thr Ala Ala Gly Ile Glu Thr Thr Gly 
        515                 520                 525             


Val Glu Leu Leu Gln Tyr Ala Val Arg Tyr His Leu Ala Arg Ala Asp 
    530                 535                 540                 


Arg Thr Thr Arg Ile Gln Tyr Tyr Tyr Arg Gly Asp Gly Gln Ile Ser 
545                 550                 555                 560 


Arg Ile Val Thr Leu Gly Gly Ala Asp Asp Pro Glu Leu Thr Gln Gln 
                565                 570                 575     


Ala Tyr Ala Leu Phe Glu Arg Ile Leu Ser Glu Pro Pro Ala Asp Ser 
            580                 585                 590         


Gly Glu Leu Pro Glu Asn Pro Leu Leu Arg Glu Phe Leu Glu Arg Ala 
        595                 600                 605             


His Leu Arg Leu Glu Gly Ser Gly Ile Arg Ile Val His Trp Lys Glu 
    610                 615                 620                 


Met Pro Tyr Ala Leu Arg Leu Tyr Phe Ser Ala Asp Gly Glu Asn Val 
625                 630                 635                 640 


Thr Ile Asp Phe Tyr Tyr Asn Arg Arg Gly Val Trp Thr His Ala Gln 
                645                 650                 655     


Glu Val Gly Arg Ser Ser Ser Gly Ala Leu Phe Ala Arg Ile Gln Ser 
            660                 665                 670         


Leu Leu Gln Ala Asp Ser 
        675             


<210>  99
<211>  496
<212>  PRT
<213>  Cyanothece ATCC51142

<400>  99

Met Ser Gln Ser Val Val Val Pro Asp Glu Leu Gly Glu Ile Ile Thr 
1               5                   10                  15      


Ala Val Ile Glu Phe Tyr Gln Asp Ala Val Asp Lys Ile Glu Pro Lys 
            20                  25                  30          


Ile Val Phe Leu Glu Leu Arg Lys Asn Val Val Asp Trp Val Ser Arg 
        35                  40                  45              


Thr Gln Leu Lys Ile Glu Glu Lys Glu Ile Gln Ala Thr Gly Leu Thr 
    50                  55                  60                  


Arg Gln Gln Gln Thr Ala Tyr Lys Glu Met Ile Asn Phe Ile Glu Asn 
65                  70                  75                  80  


Ser Ser Glu Gln Tyr Phe Arg Leu Ser Gly Tyr Ala Gly Thr Gly Lys 
                85                  90                  95      


Ser Phe Leu Met Ala Lys Val Ile Glu Trp Leu Lys Gln Glu Asp Tyr 
            100                 105                 110         


Lys Tyr Ser Val Ala Ala Pro Thr Asn Lys Ala Ala Lys Asn Leu Thr 
        115                 120                 125             


Gln Ile Ala Arg Ser Gln Gly Ile Lys Ile Glu Ala Thr Thr Val Ala 
    130                 135                 140                 


Lys Leu Leu Lys Leu Gln Pro Thr Ile Asp Val Asp Thr Gly Gln Gln 
145                 150                 155                 160 


Ser Phe Glu Phe Asn Ser Glu Lys Glu Leu Glu Leu Lys Asp Tyr Asp 
                165                 170                 175     


Val Ile Ile Ile Asp Glu Tyr Ser Met Leu Asn Lys Asp Asn Phe Arg 
            180                 185                 190         


Asp Leu Gln Gln Ala Val Lys Gly Gly Glu Ser Lys Phe Ile Phe Val 
        195                 200                 205             


Gly Asp Ser Ser Gln Leu Pro Pro Val Lys Glu Lys Glu Pro Ile Val 
    210                 215                 220                 


Ala Asn His Pro Asp Ile Arg Lys Ser Ala Asn Leu Thr Gln Ile Val 
225                 230                 235                 240 


Arg Tyr Asp Gly Glu Ile Val Lys Val Ala Glu Ser Ile Arg Arg Asn 
                245                 250                 255     


Pro Arg Trp Asn His Gln Thr Tyr Pro Phe Glu Thr Val Ala Asp Gly 
            260                 265                 270         


Thr Ile Ile Lys Leu Asn Thr Glu Asp Trp Leu Gln Gln Ala Leu Ser 
        275                 280                 285             


His Phe Glu Lys Glu Asp Trp Leu Ser Asn Pro Asp Tyr Val Arg Met 
    290                 295                 300                 


Ile Thr Trp Arg Asn Lys Thr Ala Asp Lys Tyr Asn Gln Ala Ile Arg 
305                 310                 315                 320 


Glu Ala Leu Tyr Gly Glu Asn Val Glu Gln Leu Val Val Gly Asp Arg 
                325                 330                 335     


Leu Ile Ala Lys Lys Pro Val Phe Arg Ser Leu Pro Gly Gly Lys Lys 
            340                 345                 350         


Lys Glu Lys Lys Ile Ile Leu Asn Asn Ser Glu Glu Cys Lys Val Ile 
        355                 360                 365             


Glu Thr Pro Lys Ile Asn Tyr Asn Glu Lys Tyr Lys Trp Glu Phe Tyr 
    370                 375                 380                 


Gln Val Lys Val Arg Thr Asp Glu Gly Gly Met Ile Glu Leu Arg Ile 
385                 390                 395                 400 


Leu Thr Ser Glu Ser Glu Glu Lys Arg Gln Lys Lys Leu Lys Glu Leu 
                405                 410                 415     


Ala Lys Arg Ala Arg Glu Glu Glu Asn Tyr Ser Glu Lys Lys Lys Gln 
            420                 425                 430         


Trp Ala Ile Tyr Tyr Glu Leu Asp Glu Leu Phe Asp Asn Met Ala Tyr 
        435                 440                 445             


Ala Tyr Ala Leu Thr Cys His Lys Ala Gln Gly Ser Ser Ile Asp Asn 
    450                 455                 460                 


Val Phe Leu Leu Val Ser Asp Met His Tyr Cys Arg Asp Lys Thr Lys 
465                 470                 475                 480 


Met Ile Tyr Thr Gly Leu Thr Arg Ala Lys Lys Cys Cys Tyr Val Gly 
                485                 490                 495     


<210>  100
<211>  421
<212>  PRT
<213>  Salinibacter ruber

<400>  100

Met Ser Thr Phe Ala Asp Ala Pro Phe Thr Glu Asp Gln Glu Glu Ala 
1               5                   10                  15      


Tyr Asp His Val Tyr Asp Arg Leu Ala Gln Gly Glu Arg Phe Thr Gly 
            20                  25                  30          


Leu Arg Gly Tyr Ala Gly Thr Gly Lys Thr Tyr Leu Val Ser Arg Leu 
        35                  40                  45              


Val Glu Gln Leu Leu Asp Glu Asp Cys Thr Val Thr Val Cys Ala Pro 
    50                  55                  60                  


Thr His Lys Ala Val Gln Val Leu Ser Asp Glu Leu Gly Asp Ala Pro 
65                  70                  75                  80  


Val Gln Met Gln Thr Leu His Ser Phe Leu Gly Leu Arg Leu Gln Pro 
                85                  90                  95      


Lys Gln Asp Gly Glu Tyr Glu Leu Val Ala Glu Glu Glu Arg Asn Phe 
            100                 105                 110         


Ala Glu Gly Val Val Ile Val Asp Glu Ala Ser Met Ile Gly Arg Glu 
        115                 120                 125             


Glu Trp Ser His Ile Gln Asp Ala Pro Phe Trp Val Gln Trp Leu Phe 
    130                 135                 140                 


Val Gly Asp Pro Ala Gln Leu Pro Pro Val Asn Glu Asp Pro Ser Pro 
145                 150                 155                 160 


Ala Leu Asp Val Pro Gly Pro Thr Leu Glu Thr Ile His Arg Gln Ala 
                165                 170                 175     


Ala Asp Asn Pro Ile Leu Glu Leu Ala Thr Lys Ile Arg Thr Gly Ala 
            180                 185                 190         


Asp Gly Arg Phe Gly Ser Thr Phe Glu Asp Gly Lys Gly Val Ala Val 
        195                 200                 205             


Thr Arg Asn Arg Glu Glu Phe Leu Asp Ser Ile Leu Arg Ala Phe Asp 
    210                 215                 220                 


Ala Asp Ala Phe Ala Glu Asp Ala Thr His Ala Arg Val Leu Ala Tyr 
225                 230                 235                 240 


Arg Asn Lys Thr Val Arg Arg Tyr Asn Arg Glu Ile Arg Ala Glu Arg 
                245                 250                 255     


Tyr Gly Ala Asp Ala Asp Arg Phe Val Glu Gly Glu Trp Leu Val Gly 
            260                 265                 270         


Thr Glu Thr Trp Tyr Tyr Asp Gly Val Gln Arg Leu Thr Asn Ser Glu 
        275                 280                 285             


Glu Val Arg Val Lys Lys Ala Gln Val Glu Thr Phe Glu Ala Asp Asp 
    290                 295                 300                 


Gln Ser Glu Trp Thr Val Trp Glu Leu Lys Ile Arg Thr Pro Gly Arg 
305                 310                 315                 320 


Gly Leu Thr Arg Thr Ile His Val Leu His Glu Glu Glu Arg Glu Arg 
                325                 330                 335     


Tyr Glu Asn Ala Leu Glu Arg Arg Arg Gly Lys Ala Glu Asp Asp Pro 
            340                 345                 350         


Ser Lys Trp Asp Arg Phe Phe Glu Leu Arg Glu Arg Phe Ala Arg Val 
        355                 360                 365             


Asp Tyr Ala Tyr Ala Thr Thr Val His Arg Ala Gln Gly Ser Thr Tyr 
    370                 375                 380                 


Asp Thr Val Phe Val Asp His Arg Asp Leu Arg Val Cys Arg Gly Glu 
385                 390                 395                 400 


Glu Arg Gly Ala Leu Leu Tyr Val Ala Val Thr Arg Pro Ser Arg Arg 
                405                 410                 415     


Leu Ala Leu Leu Val 
            420     


<210>  101
<211>  500
<212>  PRT
<213>  Sulfurimonas gotlandica GD1

<400>  101

Met Lys Ile Leu Asn Lys Glu Thr Tyr Lys Leu Ser Leu His Gln Glu 
1               5                   10                  15      


Glu Val Phe Thr Gln Ile Val Ser Gln Leu Asp Thr Lys Val Ser Ser 
            20                  25                  30          


Ile Leu Lys Ser Thr Asn Ile Glu Asp Tyr Leu Leu Ser Leu Thr Gly 
        35                  40                  45              


Pro Ala Gly Thr Gly Lys Thr Phe Leu Thr Thr Gln Ile Ala Lys Tyr 
    50                  55                  60                  


Leu Val Glu Lys Arg Lys Glu Ser Glu Tyr Pro Met Ser Ser Asp Phe 
65                  70                  75                  80  


Asp Phe Thr Ile Thr Ala Pro Thr His Lys Ala Val Gly Val Leu Ser 
                85                  90                  95      


Lys Leu Leu Arg Glu Asn Asn Ile Gln Ser Ser Cys Lys Thr Ile His 
            100                 105                 110         


Ser Phe Leu Gly Ile Lys Pro Phe Ile Asp Tyr Thr Thr Gly Glu Glu 
        115                 120                 125             


Lys Phe Val Val Asp Lys Thr Asn Lys Arg Lys Asp Arg Thr Ser Ile 
    130                 135                 140                 


Leu Ile Val Asp Glu Ser Ser Met Ile Gly Asn Thr Leu Tyr Glu Tyr 
145                 150                 155                 160 


Ile Leu Glu Ala Ile Glu Asp Lys Arg Val Asn Val Val Leu Phe Ile 
                165                 170                 175     


Gly Asp Pro Tyr Gln Leu Leu Pro Ile Glu Asn Ser Lys Asn Glu Ile 
            180                 185                 190         


Tyr Asp Leu Pro Asn Arg Phe Phe Leu Ser Glu Val Val Arg Gln Ala 
        195                 200                 205             


Glu Asn Ser Tyr Ile Ile Arg Val Ala Thr Lys Leu Arg Glu Arg Ile 
    210                 215                 220                 


Lys Asn Gln Asp Phe Ile Ser Leu Gln Gln Phe Phe Gln Glu Asn Met 
225                 230                 235                 240 


Glu Asp Glu Ile Thr Phe Phe His Asn Lys Glu Ala Phe Leu Glu Asp 
                245                 250                 255     


Phe Tyr Lys Glu Glu Glu Trp Tyr Lys Glu Asn Lys Ile Leu Ala Thr 
            260                 265                 270         


Tyr Lys Asn Lys Asp Val Asp Ala Phe Asn Lys Ile Ile Arg Asn Lys 
        275                 280                 285             


Phe Trp Glu Gln Lys Gly Asn Thr Thr Pro Ser Thr Leu Leu Ala Gly 
    290                 295                 300                 


Asp Met Ile Arg Phe Lys Asp Ala Tyr Thr Val Gly Asp Ile Thr Ile 
305                 310                 315                 320 


Tyr His Asn Gly Gln Glu Leu Gln Leu Gly Ser Thr Glu Val Lys Tyr 
                325                 330                 335     


His Asp Ser Leu His Ile Glu Tyr Trp Glu Cys Lys Ser Ile Tyr Ala 
            340                 345                 350         


Leu Glu Gln Gln Val Phe Arg Val Val Asn Pro Asp Ser Glu Ala Val 
        355                 360                 365             


Phe Asn Gln Lys Leu Gln Ser Leu Ala Thr Lys Ala Lys Gln Ala Lys 
    370                 375                 380                 


Phe Pro Asp Asn Lys Lys Leu Trp Lys Leu Tyr Tyr Glu Thr Arg Asn 
385                 390                 395                 400 


Met Phe Ala Asn Val Gln Tyr Ile His Ala Ser Thr Ile His Lys Leu 
                405                 410                 415     


Gln Gly Ser Thr Tyr Asp Val Ser Tyr Ile Asp Ile Phe Ser Leu Val 
            420                 425                 430         


His Asn His Tyr Met Ser Asp Glu Glu Lys Tyr Arg Leu Leu Tyr Val 
        435                 440                 445             


Ala Ile Thr Arg Ala Ser Lys Asp Ile Lys Ile Phe Met Ser Ala Phe 
    450                 455                 460                 


Asp Arg Thr Ser Asp Glu Lys Val Ile Ile Asn Asn Gln Asn Ser Glu 
465                 470                 475                 480 


Thr Met Asn Thr Leu Lys Gln Leu His Asp Ile Asp Ile Ile Leu Lys 
                485                 490                 495     


Asp Leu Asp Leu 
            500 


<210>  102
<211>  450
<212>  PRT
<213>  Vibrio phage henriette 12B8

<400>  102

Met Ala Asp Phe Glu Leu Thr Leu Gly Gln Lys Thr Val Leu Gly Glu 
1               5                   10                  15      


Val Ile Ser Thr Ile Leu Lys Pro Val Asn Leu Asn Asp Thr Ser Arg 
            20                  25                  30          


Phe His Thr Met His Gly Pro Ala Gly Ser Gly Lys Thr Thr Val Leu 
        35                  40                  45              


Gln Arg Ile Ile Ser Gln Ile Pro Ala Tyr Lys Thr Ile Gly Phe Cys 
    50                  55                  60                  


Ser Pro Thr His Lys Ser Val Lys Val Ile Arg Arg Met Ala Arg Glu 
65                  70                  75                  80  


Ala Gly Ile Ser His Arg Val Asp Ile Arg Thr Ile His Ser Ala Leu 
                85                  90                  95      


Gly Leu Val Met Lys Pro Val Arg Gly Asp Glu Val Leu Val Lys Glu 
            100                 105                 110         


Pro Phe Ala Glu Glu Arg Ile Tyr Asp Val Leu Ile Ile Asp Glu Ala 
        115                 120                 125             


Gly Met Leu Asn Asp Glu Leu Ile Met Tyr Ile Leu Glu Ser Gln Ser 
    130                 135                 140                 


Ser Lys Val Ile Phe Val Gly Asp Met Cys Gln Ile Gly Pro Ile Gln 
145                 150                 155                 160 


Ser Asn Leu Pro Glu Glu Asp Gly Tyr Thr Pro Thr Ser Thr Asp Asp 
                165                 170                 175     


Val Ser Lys Val Phe Thr Glu Val Glu Met Met Ser Ala Leu Thr Glu 
            180                 185                 190         


Val Val Arg Gln Ala Glu Gly Ser Pro Ile Ile Gln Leu Ala Thr Glu 
        195                 200                 205             


Phe Arg Leu Ala Gln Asp Asp Ile Tyr Ala Asp Leu Pro Arg Ile Val 
    210                 215                 220                 


Thr Asn Thr Thr Pro Asp Gly Asn Gly Ile Ile Thr Met Pro Asn Gly 
225                 230                 235                 240 


Asn Trp Val Asp Ser Ala Val Ala Arg Phe Gln Ser Asp Gln Phe Lys 
                245                 250                 255     


Glu Asp Pro Asp His Cys Arg Ile Val Cys Tyr Thr Asn Ala Met Val 
            260                 265                 270         


Asp Leu Cys Asn Asp Leu Val Arg Lys Arg Leu Phe Gly Ala Asp Val 
        275                 280                 285             


Pro Glu Trp Leu Glu Asp Glu Ile Leu Val Ala Gln Glu Met Gly Ser 
    290                 295                 300                 


Thr Trp Asn Asn Ala Asp Glu Leu Arg Ile Val Ser Ile Asp Asp His 
305                 310                 315                 320 


Phe Asp Gln Gln Tyr Glu Val Pro Cys Trp Arg Met Gln Leu Glu Ser 
                325                 330                 335     


Val Glu Asp His Lys Leu His Asn Ala Leu Val Val Lys Gly Asp Tyr 
            340                 345                 350         


Ile Glu Asp Phe Lys Phe Arg Leu Asn Ala Ile Ala Glu Arg Ala Asn 
        355                 360                 365             


Thr Asp Lys Asn Met Ser Gly Met His Trp Lys Glu Phe Trp Gly Met 
    370                 375                 380                 


Arg Lys Lys Phe Asn Thr Phe Lys Asn Val Tyr Ala Gly Thr Ala His 
385                 390                 395                 400 


Lys Ser Gln Gly Ser Thr Phe Asp Tyr Thr Tyr Val Phe Thr Pro Asp 
                405                 410                 415     


Phe Tyr Lys Phe Gly Ala Thr Met Thr Ile Lys Arg Leu Leu Tyr Thr 
            420                 425                 430         


Ala Ile Thr Arg Ser Arg Tyr Thr Thr Tyr Phe Ala Met Asn Thr Gly 
        435                 440                 445             


Ala Gln 
    450 


<210>  103
<211>  421
<212>  PRT
<213>  Vibrio phage phi-pp2

<400>  103

Met Gly Leu Thr Asn Cys Gln Gln Gly Ala Met Asp Ala Phe Leu Glu 
1               5                   10                  15      


Ser Asp Gly His Met Thr Ile Ser Gly Pro Ala Gly Ser Gly Lys Thr 
            20                  25                  30          


Phe Leu Met Lys Ser Ile Leu Glu Ala Leu Glu Ser Lys Gly Lys Asn 
        35                  40                  45              


Val Thr Met Val Thr Pro Thr His Gln Ala Lys Asn Val Leu His Lys 
    50                  55                  60                  


Ala Thr Gly Gln Glu Val Ser Thr Ile His Ser Leu Leu Lys Ile His 
65                  70                  75                  80  


Pro Asp Thr Tyr Glu Asp Gln Lys His Phe Thr Gln Ser Gly Glu Val 
                85                  90                  95      


Glu Gly Leu Asp Glu Ile Asp Val Leu Val Val Glu Glu Ala Ser Met 
            100                 105                 110         


Val Asp Glu Glu Leu Phe Gln Ile Thr Gly Arg Thr Met Pro Arg Lys 
        115                 120                 125             


Cys Arg Ile Leu Ala Val Gly Asp Lys Tyr Gln Leu Gln Pro Val Lys 
    130                 135                 140                 


His Asp Pro Gly Val Ile Ser Pro Phe Phe Thr Lys Phe Thr Thr Phe 
145                 150                 155                 160 


Glu Met Asn Glu Val Val Arg Gln Ala Lys Asp Asn Pro Leu Ile Gln 
                165                 170                 175     


Val Ala Thr Glu Val Arg Asn Gly Gln Trp Leu Arg Thr Asn Trp Ser 
            180                 185                 190         


Lys Glu Arg Arg Gln Gly Val Leu His Val Pro Asn Val Asn Lys Met 
        195                 200                 205             


Leu Asp Thr Tyr Leu Ser Lys Val Asn Ser Pro Glu Asp Leu Leu Asp 
    210                 215                 220                 


Tyr Arg Ile Leu Ala Tyr Thr Asn Asp Cys Val Asp Thr Phe Asn Gly 
225                 230                 235                 240 


Ile Ile Arg Glu His Val Tyr Asn Thr Ser Glu Pro Phe Ile Pro Gly 
                245                 250                 255     


Glu Tyr Leu Val Thr Gln Met Pro Val Met Val Ser Asn Gly Lys Tyr 
            260                 265                 270         


Pro Val Cys Val Ile Glu Asn Gly Glu Val Val Lys Ile Leu Asp Val 
        275                 280                 285             


Arg Gln Lys Thr Ile Asp Gly Met Leu Pro Lys Val Asp Asn Glu Ala 
    290                 295                 300                 


Phe Asp Val Ala Val Leu Thr Val Glu Lys Glu Asp Gly Asn Val Tyr 
305                 310                 315                 320 


Glu Phe Thr Val Leu Trp Asp Asp Leu Gln Lys Glu Arg Phe Ala Arg 
                325                 330                 335     


Tyr Leu Ser Val Ala Ala Gly Thr Tyr Lys Ser Met Arg Gly Asn Thr 
            340                 345                 350         


Lys Arg Tyr Trp Arg Ala Phe Trp Gly Leu Lys Glu Gln Met Ile Glu 
        355                 360                 365             


Thr Lys Ser Leu Gly Ala Ser Thr Val His Lys Ser Gln Gly Thr Thr 
    370                 375                 380                 


Val Lys Gly Val Cys Leu Tyr Thr Gln Asp Met Gly Tyr Ala Glu Pro 
385                 390                 395                 400 


Glu Ile Leu Gln Gln Leu Val Tyr Val Gly Leu Thr Arg Pro Thr Asp 
                405                 410                 415     


Trp Ala Leu Tyr Asn 
            420     


<210>  104
<211>  434
<212>  PRT
<213>  Aeromonas phage 65

<400>  104

Met Ser Glu Ser Glu Ile Thr Leu Thr Pro Ser Gln Asn Met Ala Val 
1               5                   10                  15      


Asn Glu Val Lys Asn Gly Thr Gly His Ile Thr Ile Ser Gly Pro Pro 
            20                  25                  30          


Gly Ser Gly Lys Thr Phe Leu Val Lys Tyr Leu Ile Lys Met Leu Gly 
        35                  40                  45              


Asp Glu Leu Gly Thr Val Leu Ala Ala Pro Thr His Gln Ala Lys Ile 
    50                  55                  60                  


Val Leu Thr Glu Met Ser Gly Ile Glu Ala Cys Thr Ile His Ser Leu 
65                  70                  75                  80  


Met Lys Ile His Pro Glu Thr Leu Glu Asp Ile Gln Ile Phe Asp Gln 
                85                  90                  95      


Ser Lys Leu Pro Asp Leu Ser Asn Ile Arg Tyr Leu Ile Val Glu Glu 
            100                 105                 110         


Ala Ser Met His Ser Lys Thr Leu Phe Lys Ile Thr Met Lys Ser Ile 
        115                 120                 125             


Pro Pro Thr Cys Arg Ile Ile Ala Ile Gly Asp Lys Asp Gln Ile Gln 
    130                 135                 140                 


Pro Glu Glu His Ala Gln Gly Glu Leu Ser Pro Tyr Phe Thr Asp Pro 
145                 150                 155                 160 


Arg Phe Ser Gln Ile Arg Leu Thr Asp Ile Met Arg Gln Ser Leu Asp 
                165                 170                 175     


Asn Pro Ile Ile Gln Val Ala Thr Lys Ile Arg Glu Gly Gly Trp Ile 
            180                 185                 190         


Glu Pro Asn Trp Asn Arg Asp Thr Lys Thr Gly Val Tyr Lys Val Ser 
        195                 200                 205             


Gly Ile Thr Asp Leu Val Asn Ser Tyr Leu Arg Ala Val Lys Thr Pro 
    210                 215                 220                 


Glu Asp Leu Thr Lys Tyr Arg Phe Leu Ala Tyr Thr Asn Lys Val Val 
225                 230                 235                 240 


Asn Lys Val Asn Ser Ile Val Arg Glu His Val Tyr Lys Thr Lys Leu 
                245                 250                 255     


Pro Phe Ile Glu Gly Glu Lys Ile Val Leu Gln Glu Pro Val Met Val 
            260                 265                 270         


Glu His Glu Asp Asp Thr Ile Glu Thr Ile Phe Thr Asn Gly Glu Val 
        275                 280                 285             


Val Thr Ile Asn Glu Ile Glu Val Phe Asp Arg Thr Ile Arg Ile Asp 
    290                 295                 300                 


Gly Ser Pro Glu Phe Lys Val Asn Ala Ala Lys Leu Ser Val Ser Ser 
305                 310                 315                 320 


Asp Tyr Ser Gly Ile Glu His Asp Phe Cys Val Leu Tyr Gly Ser Glu 
                325                 330                 335     


Ser Arg Leu Glu Phe Glu Tyr Gln Leu Ser Glu Ser Ala Gly Asn Ile 
            340                 345                 350         


Lys Gln Met Gly Lys Gly Gly Asn Gln Arg Ser Ala Trp Lys Ser Phe 
        355                 360                 365             


Trp Ala Ala Lys Lys Met Phe Ile Glu Thr Lys Ser Leu Gly Ala Ser 
    370                 375                 380                 


Thr Ile His Lys Ser Gln Gly Ser Thr Val Lys Gly Val Trp Leu Ala 
385                 390                 395                 400 


Leu His Asp Ile His Tyr Ala Asp Glu Glu Leu Lys Gln Gln Leu Val 
                405                 410                 415     


Tyr Val Gly Val Thr Arg Pro Thr Asp Phe Cys Leu Tyr Phe Asp Gly 
            420                 425                 430         


Thr Lys 
        


<210>  105
<211>  420
<212>  PRT
<213>  Aeromonas phage CC2

<400>  105

Met Ala Val Asp Ala Val Gln Ser Gly Thr Gly His Ile Thr Ile Ser 
1               5                   10                  15      


Gly Pro Pro Gly Ser Gly Lys Thr Phe Leu Val Lys Tyr Ile Ile Lys 
            20                  25                  30          


Met Leu Gly Asp Glu Leu Gly Thr Val Leu Ala Ala Pro Thr His Gln 
        35                  40                  45              


Ala Lys Ile Val Leu Thr Glu Met Ser Gly Ile Glu Ala Cys Thr Ile 
    50                  55                  60                  


His Ser Leu Met Lys Ile His Pro Glu Thr Leu Glu Asp Ile Gln Ile 
65                  70                  75                  80  


Phe Asp Gln Ser Lys Met Pro Asp Leu Ser Thr Val Arg Tyr Leu Ile 
                85                  90                  95      


Ile Glu Glu Ala Ser Met His Ser Lys Ala Leu Phe Asn Ile Thr Met 
            100                 105                 110         


Lys Ser Ile Pro Pro Thr Cys Arg Ile Ile Ala Ile Gly Asp Lys Asp 
        115                 120                 125             


Gln Ile Gln Pro Val Asp His Ala Pro Gly Glu Leu Ser Pro Tyr Phe 
    130                 135                 140                 


Thr Asp Ser Arg Phe Thr Gln Ile Arg Met Thr Asp Ile Met Arg Gln 
145                 150                 155                 160 


Ser Leu Asp Asn Pro Ile Ile Gln Val Ala Thr Thr Ile Arg Glu Gly 
                165                 170                 175     


Gly Trp Ile Tyr Gln Asn Trp Asn Lys Glu Lys Lys Ser Gly Val Tyr 
            180                 185                 190         


Lys Val Lys Ser Ile Thr Asp Leu Ile Asn Ser Tyr Leu Arg Val Val 
        195                 200                 205             


Lys Thr Pro Glu Asp Leu Thr Lys Tyr Arg Phe Leu Ala Phe Thr Asn 
    210                 215                 220                 


Lys Val Val Asp Lys Val Asn Ser Ile Val Arg Lys His Val Tyr Lys 
225                 230                 235                 240 


Thr Asp Leu Pro Phe Ile Glu Gly Glu Lys Leu Val Leu Gln Glu Pro 
                245                 250                 255     


Val Met Val Glu Tyr Asp Asp Asp Thr Ile Glu Thr Ile Phe Thr Asn 
            260                 265                 270         


Gly Glu Val Val Thr Val Asp Glu Ile Glu Val Ser Asp Met Asn Ile 
        275                 280                 285             


Arg Ile Asp Gly Ser Pro Ala Phe Ser Ile Ser Val Ala Lys Leu Lys 
    290                 295                 300                 


Val Thr Ser Asp Phe Ser Gly Val Thr His Asp Ile Met Ser Val Tyr 
305                 310                 315                 320 


Gly Glu Asp Ser Lys Ala Glu Phe Asn Tyr Gln Leu Ser Glu Ala Ala 
                325                 330                 335     


Ala Val Ile Lys Gln Met Gln Arg Gly Gln Thr Lys Ala Ala Trp Ala 
            340                 345                 350         


Ser Phe Trp Asp Ala Lys Lys Thr Phe Thr Glu Thr Lys Ser Leu Gly 
        355                 360                 365             


Ala Cys Thr Ile His Lys Ser Gln Gly Ser Thr Val Lys Gly Val Trp 
    370                 375                 380                 


Leu Gly Leu His Asp Ile Ser Tyr Ala Asp Thr Asp Leu Gln Gln Gln 
385                 390                 395                 400 


Leu Val Tyr Val Gly Val Thr Arg Pro Thr Asp Phe Cys Leu Tyr Phe 
                405                 410                 415     


Asp Gly Ser Lys 
            420 


<210>  106
<211>  443
<212>  PRT
<213>  Cronobacter phage vB CsaM GAP161

<400>  106

Met Ser Glu Leu Thr Phe Asp Asp Leu Ser Asp Asp Gln Lys Ser Ala 
1               5                   10                  15      


His Asp Arg Val Ile His Asn Ile Gln Asn Ala Ile His Thr Thr Ile 
            20                  25                  30          


Thr Gly Gly Pro Gly Val Gly Lys Thr Thr Leu Val Lys Phe Val Phe 
        35                  40                  45              


Asn Thr Leu Lys Gly Leu Gly Ile Ser Gly Ile Trp Leu Thr Ala Pro 
    50                  55                  60                  


Thr His Gln Ala Lys Asn Val Leu Ala Ala Ala Thr Gly Met Asp Ala 
65                  70                  75                  80  


Thr Thr Ile His Ser Ala Leu Lys Ile Ser Pro Val Thr Asn Glu Glu 
                85                  90                  95      


Leu Arg Val Phe Glu Gln Gln Lys Gly Lys Lys Ala Pro Asp Leu Ser 
            100                 105                 110         


Thr Cys Arg Val Phe Val Val Glu Glu Val Ser Met Val Asp Met Asp 
        115                 120                 125             


Leu Phe Arg Ile Ile Arg Arg Ser Ile Pro Ser Asn Ala Val Ile Leu 
    130                 135                 140                 


Gly Leu Gly Asp Lys Asp Gln Ile Arg Pro Val Asn Ala Asp Gly Arg 
145                 150                 155                 160 


Val Glu Leu Ser Pro Phe Phe Asp Glu Glu Ile Phe Asp Val Ile Arg 
                165                 170                 175     


Met Asp Lys Ile Met Arg Gln Ala Glu Gly Asn Pro Ile Ile Gln Val 
            180                 185                 190         


Ser Arg Ala Val Arg Asp Gly Lys Met Leu Lys Pro Met Ser Val Gly 
        195                 200                 205             


Asp Leu Gly Val Phe Gln His Ala Asn Ala Val Asp Phe Leu Arg Gln 
    210                 215                 220                 


Tyr Phe Arg Arg Val Lys Thr Pro Asp Asp Leu Ile Glu Asn Arg Met 
225                 230                 235                 240 


Phe Ala Tyr Thr Asn Asp Asn Val Asp Lys Leu Asn Ala Thr Ile Arg 
                245                 250                 255     


Lys His Leu Tyr Lys Thr Thr Glu Pro Phe Ile Leu Asp Glu Val Ile 
            260                 265                 270         


Val Met Gln Glu Pro Leu Val Gln Glu Met Arg Leu Asn Gly Gln Ile 
        275                 280                 285             


Phe Thr Glu Ile Val Tyr Asn Asn Asn Glu Lys Ile Arg Val Leu Glu 
    290                 295                 300                 


Ile Ile Pro Arg Arg Glu Val Ile Lys Ala Glu Lys Cys Asp Glu Lys 
305                 310                 315                 320 


Ile Glu Ile Glu Phe Tyr Leu Leu Lys Thr Val Ser Leu Glu Glu Glu 
                325                 330                 335     


Thr Glu Ala Gln Ile Gln Val Val Val Asp Pro Val Met Lys Asp Arg 
            340                 345                 350         


Leu Gly Asn Tyr Leu Ala Tyr Val Ala Ser Thr Tyr Lys Arg Ile Lys 
        355                 360                 365             


Gln Gln Thr Gly Tyr Lys Ala Pro Trp His Ser Phe Trp Ala Ile Lys 
    370                 375                 380                 


Asn Lys Phe Gln Asp Val Lys Pro Leu Pro Val Cys Thr Tyr His Lys 
385                 390                 395                 400 


Ser Gln Gly Ser Thr Tyr Asp His Ala Tyr Met Tyr Thr Arg Asp Ala 
                405                 410                 415     


Tyr Ala Phe Ala Asp Tyr Asp Leu Cys Lys Gln Leu Ile Tyr Val Gly 
            420                 425                 430         


Val Thr Arg Ala Arg Tyr Thr Val Asp Tyr Val 
        435                 440             


<210>  107
<211>  442
<212>  PRT
<213>  Klebsiella phage KP15

<400>  107

Met Ser Glu Leu Thr Phe Asp Asp Leu Ser Glu Asp Gln Lys Asn Ala 
1               5                   10                  15      


His Asp Arg Val Ile Lys Asn Ile Arg Asn Lys Ile His Thr Thr Ile 
            20                  25                  30          


Thr Gly Gly Pro Gly Val Gly Lys Thr Thr Leu Val Lys Phe Val Phe 
        35                  40                  45              


Glu Thr Leu Lys Lys Leu Gly Ile Ser Gly Ile Trp Leu Thr Ala Pro 
    50                  55                  60                  


Thr His Gln Ala Lys Asn Val Leu Ser Glu Ala Val Gly Met Asp Ala 
65                  70                  75                  80  


Thr Thr Ile His Ser Ala Leu Lys Ile Ser Pro Val Thr Asn Glu Glu 
                85                  90                  95      


Leu Arg Val Phe Glu Gln Gln Lys Gly Lys Lys Ala Ala Asp Leu Ser 
            100                 105                 110         


Glu Cys Arg Val Phe Val Val Glu Glu Val Ser Met Val Asp Lys Glu 
        115                 120                 125             


Leu Phe Arg Ile Ile Lys Arg Thr Ile Pro Ser Cys Ala Val Ile Leu 
    130                 135                 140                 


Gly Leu Gly Asp Lys Asp Gln Ile Arg Pro Val Asn Thr Glu Gly Ile 
145                 150                 155                 160 


Thr Glu Leu Ser Pro Phe Phe Asp Glu Glu Ile Phe Asp Val Ile Arg 
                165                 170                 175     


Met Asp Lys Ile Met Arg Gln Ala Glu Gly Asn Pro Ile Ile Gln Val 
            180                 185                 190         


Ser Arg Ala Ile Arg Asp Gly Lys Pro Leu Met Pro Leu Met Asn Gly 
        195                 200                 205             


Glu Leu Gly Val Met Lys His Glu Asn Ala Ser Asp Phe Leu Arg Arg 
    210                 215                 220                 


Tyr Phe Ser Arg Val Lys Thr Pro Asp Asp Leu Asn Asn Asn Arg Met 
225                 230                 235                 240 


Phe Ala Tyr Thr Asn Ala Asn Val Asp Lys Leu Asn Ala Val Ile Arg 
                245                 250                 255     


Lys His Leu Tyr Lys Thr Asp Gln Pro Phe Ile Val Gly Glu Val Val 
            260                 265                 270         


Val Met Gln Glu Pro Leu Val Thr Glu Gly Arg Val Asn Gly Val Ser 
        275                 280                 285             


Phe Val Glu Val Ile Tyr Asn Asn Asn Glu Gln Ile Lys Ile Leu Glu 
    290                 295                 300                 


Ile Ile Pro Arg Ser Asp Thr Ile Lys Ala Asp Arg Cys Asp Pro Val 
305                 310                 315                 320 


Gln Ile Asp Tyr Phe Leu Met Lys Thr Glu Ser Met Phe Glu Asp Thr 
                325                 330                 335     


Lys Ala Asp Ile Gln Val Ile Ala Asp Pro Val Met Gln Glu Arg Leu 
            340                 345                 350         


Gly Asp Tyr Leu Asn Tyr Val Ala Phe Gln Tyr Lys Lys Met Lys Gln 
        355                 360                 365             


Glu Thr Gly Tyr Lys Ala Pro Trp Tyr Ser Phe Trp Gln Ile Lys Asn 
    370                 375                 380                 


Lys Phe Gln Thr Val Lys Ala Leu Pro Val Cys Thr Tyr His Lys Gly 
385                 390                 395                 400 


Gln Gly Ser Thr Tyr Asp His Ser Tyr Met Tyr Thr Arg Asp Ala Tyr 
                405                 410                 415     


Ala Tyr Ala Asp Tyr Glu Leu Cys Lys Gln Leu Leu Tyr Val Gly Thr 
            420                 425                 430         


Thr Arg Ala Arg Phe Thr Val Asp Tyr Val 
        435                 440         


<210>  108
<211>  438
<212>  PRT
<213>  Stenotrophomonas phage IME13

<400>  108

Met Val Thr Tyr Asp Asp Leu Thr Val Gly Gln Lys Asp Ala Ile Glu 
1               5                   10                  15      


Lys Ala Leu Gln Ala Met Arg Thr Lys Arg His Ile Thr Ile Arg Gly 
            20                  25                  30          


Pro Ala Gly Ser Gly Lys Thr Thr Met Thr Arg Phe Leu Leu Glu Arg 
        35                  40                  45              


Leu Phe Gln Thr Gly Gln Gln Gly Ile Val Leu Thr Ala Pro Thr His 
    50                  55                  60                  


Gln Ala Lys Lys Glu Leu Ser Lys His Ala Leu Arg Lys Ser Tyr Thr 
65                  70                  75                  80  


Ile Gln Ser Val Leu Lys Ile Asn Pro Ser Thr Leu Glu Glu Asn Gln 
                85                  90                  95      


Ile Phe Glu Gln Lys Gly Thr Pro Asp Phe Ser Lys Thr Arg Val Leu 
            100                 105                 110         


Ile Cys Asp Glu Val Ser Phe Tyr Thr Arg Lys Leu Phe Asp Ile Leu 
        115                 120                 125             


Met Arg Asn Val Pro Ser His Cys Val Val Ile Gly Ile Gly Asp Lys 
    130                 135                 140                 


Ala Gln Ile Arg Gly Val Ser Glu Asp Asp Thr His Glu Leu Ser Pro 
145                 150                 155                 160 


Phe Phe Thr Asp Asn Arg Phe Glu Gln Val Glu Leu Thr Glu Val Lys 
                165                 170                 175     


Arg His Gln Gly Pro Ile Ile Glu Val Ala Thr Asp Ile Arg Asn Gly 
            180                 185                 190         


Lys Trp Ile Tyr Glu Lys Leu Asp Asp Ser Gly Asn Gly Val Lys Gln 
        195                 200                 205             


Phe His Thr Val Lys Asp Phe Leu Ser Lys Tyr Phe Glu Arg Thr Lys 
    210                 215                 220                 


Thr Pro Asn Asp Leu Leu Glu Asn Arg Ile Met Ala Tyr Thr Asn Asn 
225                 230                 235                 240 


Ser Val Asp Lys Leu Asn Ser Val Ile Arg Lys Gln Leu Tyr Gly Ala 
                245                 250                 255     


Asn Ala Ala Pro Phe Leu Pro Asp Glu Ile Leu Val Met Gln Glu Pro 
            260                 265                 270         


Leu Met Phe Asp Ile Asp Ile Gly Gly Gln Thr Leu Lys Glu Val Ile 
        275                 280                 285             


Phe Asn Asn Gly Gln Asn Val Arg Val Ile Asn Val Lys Pro Ser Arg 
    290                 295                 300                 


Lys Thr Leu Lys Ala Lys Gly Val Gly Glu Ile Glu Val Glu Cys Thr 
305                 310                 315                 320 


Met Leu Glu Cys Glu Ser Tyr Glu Glu Asp Glu Asp Asp Tyr Arg Arg 
                325                 330                 335     


Ala Trp Phe Thr Val Val His Asp Gln Asn Thr Gln Tyr Ala Ile Asn 
            340                 345                 350         


Glu Phe Leu Ser Ile Ile Ala Glu Lys Tyr Arg Ser Arg Glu Val Phe 
        355                 360                 365             


Pro Asn Trp Lys Asp Phe Trp Ala Ile Arg Asn Thr Phe Val Lys Val 
    370                 375                 380                 


Arg Pro Leu Gly Ala Met Thr Phe His Lys Ser Gln Gly Ser Thr Phe 
385                 390                 395                 400 


Asp Asn Ala Tyr Leu Phe Thr Pro Cys Leu His Gln Tyr Cys Arg Asp 
                405                 410                 415     


Pro Asp Val Ala Gln Glu Leu Ile Tyr Val Gly Asn Thr Arg Ala Arg 
            420                 425                 430         


Lys Asn Val Cys Phe Val 
        435             


<210>  109
<211>  442
<212>  PRT
<213>  Acinetobacter phage Ac42

<400>  109

Met Asn Phe Glu Asp Leu Thr Glu Gly Gln Lys Asn Ala Tyr Thr Ala 
1               5                   10                  15      


Ala Ile Lys Ala Ile Glu Thr Val Pro Ser Ser Ser Ala Glu Lys Arg 
            20                  25                  30          


His Leu Thr Ile Asn Gly Pro Ala Gly Thr Gly Lys Thr Thr Leu Thr 
        35                  40                  45              


Lys Phe Leu Ile Ala Glu Leu Ile Arg Arg Gly Glu Arg Gly Val Tyr 
    50                  55                  60                  


Leu Ala Ala Pro Thr His Gln Ala Lys Lys Val Leu Ser Gln His Ala 
65                  70                  75                  80  


Gly Met Glu Ala Ser Thr Ile His Ser Leu Leu Lys Ile Asn Pro Thr 
                85                  90                  95      


Thr Tyr Glu Asp Ser Thr Thr Phe Glu Gln Lys Asp Val Pro Asp Met 
            100                 105                 110         


Ser Glu Cys Arg Val Leu Ile Cys Asp Glu Ala Ser Met Tyr Asp Leu 
        115                 120                 125             


Lys Leu Phe Gln Ile Leu Met Ser Ser Ile Pro Leu Cys Cys Thr Val 
    130                 135                 140                 


Ile Ala Leu Gly Asp Ile Ala Gln Ile Arg Pro Val Glu Pro Gly Ala 
145                 150                 155                 160 


Phe Glu Gly Gln Val Ser Pro Phe Phe Thr Tyr Glu Lys Phe Glu Gln 
                165                 170                 175     


Val Ser Leu Thr Glu Val Met Arg Ser Asn Ala Pro Ile Ile Asp Val 
            180                 185                 190         


Ala Thr Ser Ile Arg Thr Gly Asn Trp Ile Tyr Glu Asn Val Ile Asp 
        195                 200                 205             


Gly Ala Gly Val His Asn Leu Thr Ser Glu Arg Ser Val Lys Ser Phe 
    210                 215                 220                 


Met Glu Lys Tyr Phe Ser Ile Val Lys Thr Pro Glu Asp Leu Phe Glu 
225                 230                 235                 240 


Asn Arg Leu Leu Ala Phe Thr Asn Lys Ser Val Asp Asp Leu Asn Lys 
                245                 250                 255     


Ile Val Arg Lys Lys Ile Tyr Asn Thr Leu Glu Pro Phe Ile Asp Gly 
            260                 265                 270         


Glu Val Leu Val Met Gln Glu Pro Leu Ile Lys Ser Tyr Thr Tyr Glu 
        275                 280                 285             


Gly Lys Lys Val Ser Glu Ile Val Phe Asn Asn Gly Glu Met Val Lys 
    290                 295                 300                 


Val Leu Cys Cys Ser Gln Thr Ser Asp Glu Ile Ser Val Arg Gly Cys 
305                 310                 315                 320 


Ser Thr Lys Tyr Met Val Arg Tyr Trp Gln Leu Asp Leu Gln Ser Leu 
                325                 330                 335     


Asp Asp Pro Asp Leu Thr Gly Ser Ile Asn Val Ile Val Asp Glu Ala 
            340                 345                 350         


Glu Ile Asn Lys Leu Asn Leu Val Leu Gly Lys Ser Ala Glu Gln Phe 
        355                 360                 365             


Lys Ser Gly Ala Val Lys Ala Ala Trp Ala Asp Trp Trp Lys Leu Lys 
    370                 375                 380                 


Arg Asn Phe His Lys Val Lys Ala Leu Pro Cys Ser Thr Ile His Lys 
385                 390                 395                 400 


Ser Gln Gly Thr Ser Val Asp Asn Val Phe Leu Tyr Thr Pro Cys Ile 
                405                 410                 415     


His Lys Ala Asp Ser Gln Leu Ala Gln Gln Leu Leu Tyr Val Gly Ala 
            420                 425                 430         


Thr Arg Ala Arg His Asn Val Tyr Tyr Ile 
        435                 440         


<210>  110
<211>  442
<212>  PRT
<213>  Shigella phage SP18

<400>  110

Met Ile Lys Phe Glu Asp Leu Asn Thr Gly Gln Lys Glu Ala Phe Asp 
1               5                   10                  15      


Tyr Ile Thr Glu Ala Ile Gln Arg Arg Ser Gly Glu Cys Ile Thr Leu 
            20                  25                  30          


Asn Gly Pro Ala Gly Thr Gly Lys Thr Thr Leu Thr Lys Phe Val Ile 
        35                  40                  45              


Asp His Leu Val Arg Asn Gly Val Met Gly Ile Val Leu Ala Ala Pro 
    50                  55                  60                  


Thr His Gln Ala Lys Lys Val Leu Ser Lys Leu Ser Gly Gln Thr Ala 
65                  70                  75                  80  


Asn Thr Ile His Ser Ile Leu Lys Ile Asn Pro Thr Thr Tyr Glu Asp 
                85                  90                  95      


Gln Asn Ile Phe Glu Gln Arg Glu Met Pro Asp Met Ser Lys Cys Asn 
            100                 105                 110         


Val Leu Val Cys Asp Glu Ala Ser Met Tyr Asp Gly Ser Leu Phe Lys 
        115                 120                 125             


Ile Ile Cys Asn Ser Val Pro Glu Trp Cys Thr Ile Leu Gly Ile Gly 
    130                 135                 140                 


Asp Met His Gln Leu Gln Pro Val Asp Pro Gly Ser Thr Gln Gln Lys 
145                 150                 155                 160 


Ile Ser Pro Phe Phe Thr His Pro Lys Phe Lys Gln Ile His Leu Thr 
                165                 170                 175     


Glu Val Met Arg Ser Asn Ala Pro Ile Ile Glu Val Ala Thr Glu Ile 
            180                 185                 190         


Arg Asn Gly Gly Trp Phe Arg Asp Cys Met Tyr Asp Gly His Gly Val 
        195                 200                 205             


Gln Gly Phe Thr Ser Gln Thr Ala Leu Lys Asp Phe Met Val Asn Tyr 
    210                 215                 220                 


Phe Gly Ile Val Lys Asp Ala Asp Met Leu Met Glu Asn Arg Met Tyr 
225                 230                 235                 240 


Ala Tyr Thr Asn Lys Ser Val Glu Lys Leu Asn Asn Ile Ile Arg Arg 
                245                 250                 255     


Lys Leu Tyr Glu Thr Asp Lys Ala Phe Leu Pro Tyr Glu Val Leu Val 
            260                 265                 270         


Met Gln Glu Pro His Met Lys Glu Leu Glu Phe Glu Gly Lys Lys Phe 
        275                 280                 285             


Ser Glu Thr Ile Phe Asn Asn Gly Gln Leu Val Arg Ile Lys Asp Cys 
    290                 295                 300                 


Lys Tyr Thr Ser Thr Ile Leu Arg Cys Lys Gly Glu Ser His Gln Leu 
305                 310                 315                 320 


Val Ile Asn Tyr Trp Asp Leu Glu Val Glu Ser Ile Asp Glu Asp Glu 
                325                 330                 335     


Glu Tyr Gln Val Asp Arg Ile Lys Val Leu Pro Glu Asp Gln Gln Pro 
            340                 345                 350         


Lys Phe Gln Ala Tyr Leu Ala Lys Val Ala Asp Thr Tyr Lys Gln Met 
        355                 360                 365             


Lys Ala Ala Gly Lys Arg Pro Glu Trp Lys Asp Phe Trp Lys Ala Arg 
    370                 375                 380                 


Arg Thr Phe Leu Lys Val Arg Ala Leu Pro Val Ser Thr Ile His Lys 
385                 390                 395                 400 


Ala Gln Gly Val Ser Val Asp Lys Ala Phe Ile Tyr Thr Pro Cys Ile 
                405                 410                 415     


His Met Ala Glu Ala Ser Leu Ala Ser Gln Leu Ala Tyr Val Gly Ile 
            420                 425                 430         


Thr Arg Ala Arg Tyr Asp Ala Tyr Tyr Val 
        435                 440         


<210>  111
<211>  439
<212>  PRT
<213>  Yersinia phage phiR1-RT

<400>  111

Met Ile Thr Tyr Asp Asp Leu Thr Asp Gly Gln Lys Ser Ala Phe Asp 
1               5                   10                  15      


Asn Thr Met Glu Ala Ile Lys Asn Lys Lys Gly His Ile Thr Ile Asn 
            20                  25                  30          


Gly Pro Ala Gly Thr Gly Lys Thr Thr Leu Thr Lys Phe Ile Ile Asp 
        35                  40                  45              


His Leu Ile Lys Thr Gly Glu Ala Gly Ile Ile Leu Cys Ala Pro Thr 
    50                  55                  60                  


His Gln Ala Lys Lys Val Leu Ser Lys Leu Ser Gly Met Asp Ala Ser 
65                  70                  75                  80  


Thr Ile His Ser Val Leu Lys Ile Asn Pro Thr Thr Tyr Glu Glu Asn 
                85                  90                  95      


Gln Ile Phe Glu Gln Arg Glu Val Pro Asp Leu Ala Ala Cys Arg Val 
            100                 105                 110         


Leu Ile Cys Asp Glu Ala Ser Phe Tyr Asp Arg Lys Leu Phe Gly Ile 
        115                 120                 125             


Ile Leu Ala Thr Val Pro Ser Trp Cys Thr Val Ile Ala Leu Gly Asp 
    130                 135                 140                 


Lys Asp Gln Leu Arg Pro Val Thr Pro Gly Glu Ser Glu Gln Gln Leu 
145                 150                 155                 160 


Ser Pro Phe Phe Ser His Ala Lys Phe Lys Gln Val His Leu Thr Glu 
                165                 170                 175     


Ile Lys Arg Ser Asn Gly Pro Ile Ile Gln Val Ala Thr Asp Ile Arg 
            180                 185                 190         


Asn Gly Gly Trp Leu Ser Glu Asn Ile Val Asp Gly Glu Gly Val His 
        195                 200                 205             


Ala Phe Asn Ser Asn Thr Ala Leu Lys Asp Phe Met Ile Arg Tyr Phe 
    210                 215                 220                 


Asp Val Val Lys Thr Ala Asp Asp Leu Ile Glu Ser Arg Met Leu Ala 
225                 230                 235                 240 


Tyr Thr Asn Lys Ser Val Asp Lys Leu Asn Gly Ile Ile Arg Arg Lys 
                245                 250                 255     


Leu Tyr Glu Thr Asp Lys Pro Phe Ile Asn Gly Glu Val Leu Val Met 
            260                 265                 270         


Gln Glu Pro Leu Met Lys Glu Leu Glu Phe Asp Gly Lys Lys Phe His 
        275                 280                 285             


Glu Ile Val Phe Asn Asn Gly Gln Leu Val Lys Ile Leu Tyr Ala Ser 
    290                 295                 300                 


Glu Thr Ser Thr Phe Ile Ser Ala Arg Asn Val Pro Gly Glu Tyr Met 
305                 310                 315                 320 


Ile Arg Tyr Trp Asn Leu Glu Val Glu Thr Ala Asp Ser Asp Asp Asp 
                325                 330                 335     


Tyr Ala Thr Ser Gln Ile Gln Val Ile Cys Asp Pro Ala Glu Met Thr 
            340                 345                 350         


Lys Phe Gln Met Phe Leu Ala Lys Thr Ala Asp Thr Tyr Lys Asn Ser 
        355                 360                 365             


Gly Val Lys Ala Tyr Trp Lys Asp Phe Trp Ser Val Lys Asn Lys Phe 
    370                 375                 380                 


Lys Lys Val Lys Ala Leu Pro Val Ser Thr Ile His Lys Ser Gln Gly 
385                 390                 395                 400 


Cys Thr Val Asn Asn Thr Phe Leu Tyr Thr Pro Cys Ile His Met Ala 
                405                 410                 415     


Asp Ala Gln Leu Ala Lys Gln Leu Leu Tyr Val Gly Ala Thr Arg Ala 
            420                 425                 430         


Arg Thr Asn Leu Tyr Tyr Ile 
        435                 


<210>  112
<211>  441
<212>  PRT
<213>  Salmonella phage S16

<400>  112

Met Ile Thr Phe Glu Gln Leu Thr Ser Gly Gln Lys Leu Ala Phe Asp 
1               5                   10                  15      


Glu Thr Ile Arg Ala Ile Lys Glu Lys Lys Asn His Val Thr Ile Asn 
            20                  25                  30          


Gly Pro Ala Gly Thr Gly Lys Thr Thr Leu Thr Lys Phe Ile Met Glu 
        35                  40                  45              


His Leu Val Ser Thr Gly Glu Thr Gly Ile Ile Leu Thr Ala Pro Thr 
    50                  55                  60                  


His Ala Ala Lys Lys Val Leu Thr Lys Leu Ser Gly Met Glu Ala Asn 
65                  70                  75                  80  


Thr Ile His Lys Ile Leu Lys Ile Asn Pro Thr Thr Tyr Glu Glu Ser 
                85                  90                  95      


Met Leu Phe Glu Gln Lys Glu Val Pro Asp Leu Ala Ser Cys Arg Val 
            100                 105                 110         


Leu Ile Cys Asp Glu Ala Ser Met Trp Asp Arg Lys Leu Phe Lys Ile 
        115                 120                 125             


Leu Met Ala Ser Ile Pro Lys Trp Cys Thr Ile Val Ala Ile Gly Asp 
    130                 135                 140                 


Val Ala Gln Ile Arg Pro Val Asp Pro Gly Glu Thr Glu Ala His Ile 
145                 150                 155                 160 


Ser Pro Phe Phe Ile His Lys Asp Phe Lys Gln Leu Asn Leu Thr Glu 
                165                 170                 175     


Val Met Arg Ser Asn Ala Pro Ile Ile Asp Val Ala Thr Asp Ile Arg 
            180                 185                 190         


Asn Gly Ser Trp Ile Tyr Glu Lys Thr Val Asp Gly His Gly Val His 
        195                 200                 205             


Gly Phe Thr Ser Thr Thr Ala Leu Lys Asp Phe Met Met Gln Tyr Phe 
    210                 215                 220                 


Ser Ile Val Lys Ser Pro Glu Asp Leu Phe Glu Asn Arg Met Leu Ala 
225                 230                 235                 240 


Phe Thr Asn Lys Ser Val Asp Lys Leu Asn Ser Ile Ile Arg Arg Arg 
                245                 250                 255     


Leu Tyr Gln Thr Glu Glu Ala Phe Val Val Gly Glu Val Ile Val Met 
            260                 265                 270         


Gln Glu Pro Leu Met Arg Glu Leu Val Phe Glu Gly Lys Lys Phe His 
        275                 280                 285             


Glu Thr Leu Phe Thr Asn Gly Gln Tyr Val Arg Ile Leu Ser Ala Asp 
    290                 295                 300                 


Tyr Thr Ser Ser Phe Leu Gly Ala Lys Gly Val Ser Gly Glu His Leu 
305                 310                 315                 320 


Ile Arg His Trp Val Leu Asp Val Glu Thr Tyr Asp Asp Glu Glu Tyr 
                325                 330                 335     


Ala Arg Glu Lys Ile Asn Val Ile Ser Asp Glu Gln Glu Met Asn Lys 
            340                 345                 350         


Phe Gln Phe Phe Leu Ala Lys Thr Ala Asp Thr Tyr Lys Asn Trp Asn 
        355                 360                 365             


Lys Gly Gly Lys Ala Pro Trp Ser Glu Phe Trp Asp Ala Lys Arg Lys 
    370                 375                 380                 


Phe His Lys Val Lys Ala Leu Pro Cys Ser Thr Phe His Lys Ala Gln 
385                 390                 395                 400 


Gly Ile Ser Val Asp Ser Ser Phe Ile Tyr Thr Pro Cys Ile His Val 
                405                 410                 415     


Ser Ser Asp Asn Lys Phe Lys Leu Glu Leu Leu Tyr Val Gly Ala Thr 
            420                 425                 430         


Arg Gly Arg His Asp Val Phe Phe Val 
        435                 440     


<210>  113
<211>  786
<212>  DNA
<213>  Escherichia coli

<400>  113
tgtctgaccg caccgccgaa agaagcggca cgtccgaccc tgatgccgcg tgcacagtct       60

tataaagatc tgacccatct gccggctccg acgggcaaaa tttttgttag cgtctataac      120

atccaggacg aaaccggtca atttaaaccg tacccggcga gtaatttctc cacggccgtt      180

ccgcagagtg caaccgctat gctggtcacg gcactgaaag attcccgttg gttcattccg      240

ctggaacgcc agggcctgca aaacctgctg aatgaacgta aaattatccg cgcagctcag      300

gaaaacggta ccgtggccat taacaatcgt attccgctgc aaagcctgac cgccgcaaac      360

atcatggttg aaggctctat catcggttac gaatcaaacg tcaaatcggg cggtgtgggc      420

gcacgttatt ttggcattgg tgctgatacc cagtaccaac tggaccagat cgcagttaac      480

ctgcgcgtgg ttaatgtcag caccggcgaa attctgagct ctgtgaatac cagcaaaacg      540

atcctgtctt acgaagtgca ggctggtgtt tttcgtttca ttgattatca acgcctgctg      600

gaaggcgaag tcggttacac ctcaaacgaa ccggtgatgc tgtgtctgat gtcggcgatt      660

gaaacgggtg ttattttcct gatcaatgat ggcatcgacc gtggtctgtg ggatctgcag      720

aacaaagccg aacgtcaaaa tgacattctg gtgaaatacc gccacatgag tgttccgccg      780

gaatcc                                                                 786


<210>  114
<211>  262
<212>  PRT
<213>  Escherichia coli

<400>  114

Cys Leu Thr Ala Pro Pro Lys Glu Ala Ala Arg Pro Thr Leu Met Pro 
1               5                   10                  15      


Arg Ala Gln Ser Tyr Lys Asp Leu Thr His Leu Pro Ala Pro Thr Gly 
            20                  25                  30          


Lys Ile Phe Val Ser Val Tyr Asn Ile Gln Asp Glu Thr Gly Gln Phe 
        35                  40                  45              


Lys Pro Tyr Pro Ala Ser Asn Phe Ser Thr Ala Val Pro Gln Ser Ala 
    50                  55                  60                  


Thr Ala Met Leu Val Thr Ala Leu Lys Asp Ser Arg Trp Phe Ile Pro 
65                  70                  75                  80  


Leu Glu Arg Gln Gly Leu Gln Asn Leu Leu Asn Glu Arg Lys Ile Ile 
                85                  90                  95      


Arg Ala Ala Gln Glu Asn Gly Thr Val Ala Ile Asn Asn Arg Ile Pro 
            100                 105                 110         


Leu Gln Ser Leu Thr Ala Ala Asn Ile Met Val Glu Gly Ser Ile Ile 
        115                 120                 125             


Gly Tyr Glu Ser Asn Val Lys Ser Gly Gly Val Gly Ala Arg Tyr Phe 
    130                 135                 140                 


Gly Ile Gly Ala Asp Thr Gln Tyr Gln Leu Asp Gln Ile Ala Val Asn 
145                 150                 155                 160 


Leu Arg Val Val Asn Val Ser Thr Gly Glu Ile Leu Ser Ser Val Asn 
                165                 170                 175     


Thr Ser Lys Thr Ile Leu Ser Tyr Glu Val Gln Ala Gly Val Phe Arg 
            180                 185                 190         


Phe Ile Asp Tyr Gln Arg Leu Leu Glu Gly Glu Val Gly Tyr Thr Ser 
        195                 200                 205             


Asn Glu Pro Val Met Leu Cys Leu Met Ser Ala Ile Glu Thr Gly Val 
    210                 215                 220                 


Ile Phe Leu Ile Asn Asp Gly Ile Asp Arg Gly Leu Trp Asp Leu Gln 
225                 230                 235                 240 


Asn Lys Ala Glu Arg Gln Asn Asp Ile Leu Val Lys Tyr Arg His Met 
                245                 250                 255     


Ser Val Pro Pro Glu Ser 
            260         


<210>  115
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Transposon top strand

<400>  115
gttttcgcat ttatcgtgaa acgctttcgc gtttttcgtg cgccgcttca                  50


<210>  116
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Adapter annealing sequence to form transposon 1


<220>
<221>  misc_feature
<222>  (50)..(50)
<223>  n = U

<400>  116
caaaagcgta aatagcactt tgcgaaagcg caaaaagcac gcggcgaagn ctag             54


<210>  117
<211>  64
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Adapter annealing sequence to form transposon 2

<400>  117
gatctgaagc ggcgcacgaa aaacgcgaaa gcgtttcacg ataaatgcga aaactttttt       60

tttt                                                                    64


<210>  118
<211>  12
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Adapter annealing sequence attached at 5' end to 3' end of iSpC3 
       spacers

<400>  118
tttttttttt tt                                                           12


<210>  119
<211>  77
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Adapter annealing sequence attached at 5' end to 3' end of iSp18 
       spacers

<400>  119
ggttgtttct gttggtgctg atattgcgtt ttcgcattta tcgtgaaacg ctttcgcgtt       60

tttcgtgcgc cgcttca                                                      77


<210>  120
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Polynucleotide used in the Examples

<400>  120
gcaatatcag caccaacaga aacaacctt                                         29


<210>  121
<211>  62
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Polynucleotide used in the Examples

<400>  121
tgctgatatt gcgttttcgc atttatcgtg aaacgctttc gcgtttttcg tgcgccgctt       60

ca                                                                      62


<210>  122
<211>  753
<212>  PRT
<213>  Escherichia coli

<400>  122

Met Asp Val Ser Tyr Leu Leu Asp Ser Leu Asn Asp Lys Gln Arg Glu 
1               5                   10                  15      


Ala Val Ala Ala Pro Arg Ser Asn Leu Leu Val Leu Ala Gly Ala Gly 
            20                  25                  30          


Ser Gly Lys Thr Arg Val Leu Val His Arg Ile Ala Trp Leu Met Ser 
        35                  40                  45              


Val Glu Asn Cys Ser Pro Tyr Ser Ile Met Ala Val Thr Phe Thr Asn 
    50                  55                  60                  


Lys Ala Ala Ala Glu Met Arg His Arg Ile Gly Gln Leu Met Gly Thr 
65                  70                  75                  80  


Ser Gln Gly Gly Met Trp Val Gly Thr Phe His Gly Leu Ala His Arg 
                85                  90                  95      


Leu Leu Arg Ala His His Met Asp Ala Asn Leu Pro Gln Asp Phe Gln 
            100                 105                 110         


Ile Leu Asp Ser Glu Asp Gln Leu Arg Leu Leu Lys Arg Leu Ile Lys 
        115                 120                 125             


Ala Met Asn Leu Asp Glu Lys Gln Trp Pro Pro Arg Gln Ala Met Trp 
    130                 135                 140                 


Tyr Ile Asn Ser Gln Lys Asp Glu Gly Leu Arg Pro His His Ile Gln 
145                 150                 155                 160 


Ser Tyr Gly Asn Pro Val Glu Gln Thr Trp Gln Lys Val Tyr Gln Ala 
                165                 170                 175     


Tyr Gln Glu Ala Cys Asp Arg Ala Gly Leu Val Asp Phe Ala Glu Leu 
            180                 185                 190         


Leu Leu Arg Ala His Glu Leu Trp Leu Asn Lys Pro His Ile Leu Gln 
        195                 200                 205             


His Tyr Arg Glu Arg Phe Thr Asn Ile Leu Val Asp Glu Phe Gln Asp 
    210                 215                 220                 


Thr Asn Asn Ile Gln Tyr Ala Trp Ile Arg Leu Leu Ala Gly Asp Thr 
225                 230                 235                 240 


Gly Lys Val Met Ile Val Gly Asp Asp Asp Gln Ser Ile Tyr Gly Trp 
                245                 250                 255     


Arg Gly Ala Gln Val Glu Asn Ile Gln Arg Phe Leu Asn Asp Phe Pro 
            260                 265                 270         


Gly Ala Glu Thr Ile Arg Leu Glu Gln Asn Tyr Arg Ser Thr Ser Asn 
        275                 280                 285             


Ile Leu Ser Ala Ala Asn Ala Leu Ile Glu Asn Asn Asn Gly Arg Leu 
    290                 295                 300                 


Gly Lys Lys Leu Trp Thr Asp Gly Ala Asp Gly Glu Pro Ile Ser Leu 
305                 310                 315                 320 


Tyr Cys Ala Phe Asn Glu Leu Asp Glu Ala Arg Phe Val Val Asn Arg 
                325                 330                 335     


Ile Lys Thr Trp Gln Asp Asn Gly Gly Ala Leu Ala Glu Cys Ala Ile 
            340                 345                 350         


Leu Tyr Arg Ser Asn Ala Gln Ser Arg Val Leu Glu Glu Ala Leu Leu 
        355                 360                 365             


Gln Ala Ser Met Pro Tyr Arg Ile Tyr Gly Gly Met Arg Phe Phe Glu 
    370                 375                 380                 


Arg Gln Glu Ile Lys Asp Ala Leu Ser Tyr Leu Arg Leu Ile Ala Asn 
385                 390                 395                 400 


Arg Asn Asp Asp Ala Ala Phe Glu Arg Val Val Asn Thr Pro Thr Arg 
                405                 410                 415     


Gly Ile Gly Asp Arg Thr Leu Asp Val Val Arg Gln Thr Ser Arg Asp 
            420                 425                 430         


Arg Gln Leu Thr Leu Trp Gln Ala Cys Arg Glu Leu Leu Gln Glu Lys 
        435                 440                 445             


Ala Leu Ala Gly Arg Ala Ala Ser Ala Leu Gln Arg Phe Met Glu Leu 
    450                 455                 460                 


Ile Asp Ala Leu Ala Gln Glu Thr Ala Asp Met Pro Leu His Val Gln 
465                 470                 475                 480 


Thr Asp Arg Val Ile Lys Asp Ser Gly Leu Arg Thr Met Tyr Glu Gln 
                485                 490                 495     


Glu Lys Gly Glu Lys Gly Gln Thr Arg Ile Glu Asn Leu Glu Glu Leu 
            500                 505                 510         


Val Thr Ala Thr Arg Gln Phe Ser Tyr Asn Glu Glu Asp Glu Asp Leu 
        515                 520                 525             


Met Pro Leu Gln Ala Phe Leu Ser His Ala Ala Leu Glu Ala Gly Glu 
    530                 535                 540                 


Gly Gln Ala Asp Thr Trp Gln Asp Ala Val Gln Leu Met Thr Leu His 
545                 550                 555                 560 


Ser Ala Lys Gly Leu Glu Phe Pro Gln Val Phe Ile Val Gly Met Glu 
                565                 570                 575     


Glu Gly Met Phe Pro Ser Gln Met Ser Leu Asp Glu Gly Gly Arg Leu 
            580                 585                 590         


Glu Glu Glu Arg Arg Leu Ala Tyr Val Gly Val Thr Arg Ala Met Gln 
        595                 600                 605             


Lys Leu Thr Leu Thr Tyr Ala Glu Thr Arg Arg Leu Tyr Gly Lys Glu 
    610                 615                 620                 


Val Tyr His Arg Pro Ser Arg Phe Ile Gly Glu Leu Pro Glu Glu Cys 
625                 630                 635                 640 


Val Glu Glu Val Arg Leu Arg Ala Thr Val Ser Arg Pro Val Ser His 
                645                 650                 655     


Gln Arg Met Gly Thr Pro Met Val Glu Asn Asp Ser Gly Tyr Lys Leu 
            660                 665                 670         


Gly Gln Arg Val Arg His Ala Lys Phe Gly Glu Gly Thr Ile Val Asn 
        675                 680                 685             


Met Glu Gly Ser Gly Glu His Ser Arg Leu Gln Val Ala Phe Gln Gly 
    690                 695                 700                 


Gln Gly Ile Lys Trp Leu Val Ala Ala Tyr Ala Arg Leu Glu Ser Val 
705                 710                 715                 720 


Ser Gly Gly Ser Ala Trp Ser His Pro Gln Phe Glu Lys Gly Gly Gly 
                725                 730                 735     


Ser Gly Gly Gly Ser Gly Gly Ser Ala Trp Ser His Pro Gln Phe Glu 
            740                 745                 750         


Lys 
    


