                         SEQUENCE LISTING

<110>  Danmarks Tekniske Universitet
 
<120>  VARIANTS OF ACETYLSEROTONIN 0-METHYLTRANSFERASE AND USES THEREOF

<130>  20693

<160>  20    

<170>  PatentIn version 3.5

<210>  1
<211>  345
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Gly Ser Ser Glu Asp Gln Ala Tyr Arg Leu Leu Asn Asp Tyr Ala 
1               5                   10                  15      


Asn Gly Phe Met Val Ser Gln Val Leu Phe Ala Ala Cys Glu Leu Gly 
            20                  25                  30          


Val Phe Asp Leu Leu Ala Glu Ala Pro Gly Pro Leu Asp Val Ala Ala 
        35                  40                  45              


Val Ala Ala Gly Val Arg Ala Ser Ala His Gly Thr Glu Leu Leu Leu 
    50                  55                  60                  


Asp Ile Cys Val Ser Leu Lys Leu Leu Lys Val Glu Thr Arg Gly Gly 
65                  70                  75                  80  


Lys Ala Phe Tyr Arg Asn Thr Glu Leu Ser Ser Asp Tyr Leu Thr Thr 
                85                  90                  95      


Val Ser Pro Thr Ser Gln Cys Ser Met Leu Lys Tyr Met Gly Arg Thr 
            100                 105                 110         


Ser Tyr Arg Cys Trp Gly His Leu Ala Asp Ala Val Arg Glu Gly Arg 
        115                 120                 125             


Asn Gln Tyr Leu Glu Thr Phe Gly Val Pro Ala Glu Glu Leu Phe Thr 
    130                 135                 140                 


Ala Ile Tyr Arg Ser Glu Gly Glu Arg Leu Gln Phe Met Gln Ala Leu 
145                 150                 155                 160 


Gln Glu Val Trp Ser Val Asn Gly Arg Ser Val Leu Thr Ala Phe Asp 
                165                 170                 175     


Leu Ser Val Phe Pro Leu Met Cys Asp Leu Gly Gly Gly Ala Gly Ala 
            180                 185                 190         


Leu Ala Lys Glu Cys Met Ser Leu Tyr Pro Gly Cys Lys Ile Thr Val 
        195                 200                 205             


Phe Asp Ile Pro Glu Val Val Trp Thr Ala Lys Gln His Phe Ser Phe 
    210                 215                 220                 


Gln Glu Glu Glu Gln Ile Asp Phe Gln Glu Gly Asp Phe Phe Lys Asp 
225                 230                 235                 240 


Pro Leu Pro Glu Ala Asp Leu Tyr Ile Leu Ala Arg Val Leu His Asp 
                245                 250                 255     


Trp Ala Asp Gly Lys Cys Ser His Leu Leu Glu Arg Ile Tyr His Thr 
            260                 265                 270         


Cys Lys Pro Gly Gly Gly Ile Leu Val Ile Glu Ser Leu Leu Asp Glu 
        275                 280                 285             


Asp Arg Arg Gly Pro Leu Leu Thr Gln Leu Tyr Ser Leu Asn Met Leu 
    290                 295                 300                 


Val Gln Thr Glu Gly Gln Glu Arg Thr Pro Thr His Tyr His Met Leu 
305                 310                 315                 320 


Leu Ser Ser Ala Gly Phe Arg Asp Phe Gln Phe Lys Lys Thr Gly Ala 
                325                 330                 335     


Ile Tyr Asp Ala Ile Leu Ala Arg Lys 
            340                 345 


<210>  2
<211>  361
<212>  PRT
<213>  Ocimicum basilicum

<400>  2

Met Ser Ser Thr Ala Asn Asn Pro Gln Ile Asn Ser Asp Glu Glu Glu 
1               5                   10                  15      


Asn Phe Leu Phe Ala Met Gln Leu Ala Ser Ala Ser Val Leu Pro Met 
            20                  25                  30          


Val Leu Lys Ser Ala Ile Glu Leu Asp Leu Leu Glu Leu Ile Lys Lys 
        35                  40                  45              


Ala Gly Ala Gly Ala Phe Val Ser Pro Ala Glu Leu Ala Ala Gln Leu 
    50                  55                  60                  


Leu Thr Thr Asn Ala Glu Ala His Val Met Leu Asp Arg Ile Leu Arg 
65                  70                  75                  80  


Leu Leu Thr Ser Tyr Ala Ile Leu Glu Cys Arg Leu Lys Thr Leu Pro 
                85                  90                  95      


Asp Gly Gly Val Gln Arg Leu Tyr Gly Leu Ala Pro Val Cys Lys Phe 
            100                 105                 110         


Leu Thr Lys Asn Glu Asp Gly Val Ser Met Ala Pro Leu Ala Leu Met 
        115                 120                 125             


Asn Gln Asp Lys Val Leu Met Glu Ser Trp Tyr His Leu Lys Asp Ala 
    130                 135                 140                 


Val Leu Asp Gly Gly Ile Pro Phe Asn Lys Ala Tyr Gly Met Thr Ala 
145                 150                 155                 160 


Phe Glu Tyr His Gly Thr Asp Pro Arg Phe Asn Lys Val Phe Asn Gln 
                165                 170                 175     


Gly Met Ser Asn His Ser Thr Ile Thr Met Lys Lys Ile Leu Glu Thr 
            180                 185                 190         


Tyr Thr Gly Phe Asp Gly Leu Lys Thr Val Val Asp Val Gly Gly Gly 
        195                 200                 205             


Thr Gly Ala Thr Leu Asn Met Ile Ile Ser Lys Tyr Pro Ser Ile Lys 
    210                 215                 220                 


Gly Ile Asn Phe Asp Leu Pro His Val Val Glu Asp Ala Pro Ser Tyr 
225                 230                 235                 240 


Pro Gly Val Glu His Val Gly Gly Asp Met Phe Val Ser Val Pro Lys 
                245                 250                 255     


Gly Asp Ala Ile Phe Met Lys Trp Ile Cys His Asp Trp Ser Asp Ala 
            260                 265                 270         


His Cys Val Lys Phe Leu Lys Lys Cys Tyr Glu Ala Leu Pro Glu Asn 
        275                 280                 285             


Gly Lys Val Ile Leu Ala Glu Cys Val Leu Pro Glu Ala Pro Asp Thr 
    290                 295                 300                 


Gly Leu Ala Thr Lys Asn Val Val His Ile Asp Val Ile Met Leu Ala 
305                 310                 315                 320 


His Asn Pro Gly Gly Lys Glu Arg Thr Glu Lys Glu Phe Gln Val Leu 
                325                 330                 335     


Ala Lys Ala Ser Gly Phe Lys Gln Phe Asn Lys Val Cys Cys Ala Tyr 
            340                 345                 350         


Asn Ser Trp Ile Met Glu Leu Leu Lys 
        355                 360     


<210>  3
<211>  345
<212>  PRT
<213>  Bos taurus

<400>  3

Met Cys Ser Gln Glu Gly Glu Gly Tyr Ser Leu Leu Lys Glu Tyr Ala 
1               5                   10                  15      


Asn Gly Phe Met Val Ser Gln Val Leu Phe Ala Ala Cys Glu Leu Gly 
            20                  25                  30          


Val Phe Glu Leu Leu Ala Glu Ala Leu Glu Pro Leu Asp Ser Ala Ala 
        35                  40                  45              


Val Ser Ser His Leu Gly Ser Ser Pro Gln Gly Thr Glu Leu Leu Leu 
    50                  55                  60                  


Asn Thr Cys Val Ser Leu Lys Leu Leu Gln Ala Asp Val Arg Gly Gly 
65                  70                  75                  80  


Lys Ala Val Tyr Ala Asn Thr Glu Leu Ala Ser Thr Tyr Leu Val Arg 
                85                  90                  95      


Gly Ser Pro Arg Ser Gln Arg Asp Met Leu Leu Tyr Ala Gly Arg Thr 
            100                 105                 110         


Ala Tyr Val Cys Trp Arg His Leu Ala Glu Ala Val Arg Glu Gly Arg 
        115                 120                 125             


Asn Gln Tyr Leu Lys Ala Phe Gly Ile Pro Ser Glu Glu Leu Phe Ser 
    130                 135                 140                 


Ala Ile Tyr Arg Ser Glu Asp Glu Arg Leu Gln Phe Met Gln Gly Leu 
145                 150                 155                 160 


Gln Asp Val Trp Arg Leu Glu Gly Ala Thr Val Leu Ala Ala Phe Asp 
                165                 170                 175     


Leu Ser Pro Phe Pro Leu Ile Cys Asp Leu Gly Gly Gly Ser Gly Ala 
            180                 185                 190         


Leu Ala Lys Ala Cys Val Ser Leu Tyr Pro Gly Cys Arg Ala Ile Val 
        195                 200                 205             


Phe Asp Ile Pro Gly Val Val Gln Ile Ala Lys Arg His Phe Ser Ala 
    210                 215                 220                 


Ser Glu Asp Glu Arg Ile Ser Phe His Glu Gly Asp Phe Phe Lys Asp 
225                 230                 235                 240 


Ala Leu Pro Glu Ala Asp Leu Tyr Ile Leu Ala Arg Val Leu His Asp 
                245                 250                 255     


Trp Thr Asp Ala Lys Cys Ser His Leu Leu Gln Arg Val Tyr Arg Ala 
            260                 265                 270         


Cys Arg Thr Gly Gly Gly Ile Leu Val Ile Glu Ser Leu Leu Asp Thr 
        275                 280                 285             


Asp Gly Arg Gly Pro Leu Thr Thr Leu Leu Tyr Ser Leu Asn Met Leu 
    290                 295                 300                 


Val Gln Thr Glu Gly Arg Glu Arg Thr Pro Ala Glu Tyr Arg Ala Leu 
305                 310                 315                 320 


Leu Gly Pro Ala Gly Phe Arg Asp Val Arg Cys Arg Arg Thr Gly Gly 
                325                 330                 335     


Thr Tyr Asp Ala Val Leu Ala Arg Lys 
            340                 345 


<210>  4
<211>  335
<212>  PRT
<213>  Takifugu rubripes

<400>  4

Met Phe Leu Ile Ala His Leu Pro Leu Pro Gln Val Val Phe Ser Ser 
1               5                   10                  15      


Cys Glu Leu Gly Val Phe Asp Leu Leu Leu Gly Ala Glu Arg Pro Leu 
            20                  25                  30          


Ser Ala Glu Glu Ile Ser Arg Ala Leu Gly Thr Ser Val Asp Gly Thr 
        35                  40                  45              


Glu Arg Leu Leu Ala Ala Cys Ser Gly Leu Gln Leu Leu Asn Ile His 
    50                  55                  60                  


Gln Asp Asn Gly Arg Cys Leu Tyr Ser Asn Thr Asp Gln Ala Ser Val 
65                  70                  75                  80  


Tyr Leu Thr Arg Ser Ser Pro Val Ser Leu Ser Gln Ser Ile Gln Tyr 
                85                  90                  95      


Ser Ser Arg Thr Ile Tyr Leu Cys Trp His Tyr Leu Thr Asp Ala Val 
            100                 105                 110         


Arg Glu Gly Arg Asn Gln Tyr Glu Lys Ala Phe Gly Val Asp Ala Gln 
        115                 120                 125             


Asp Leu Phe Gln Ala Leu Tyr Arg Ser Asp Glu Glu Met Val Lys Phe 
    130                 135                 140                 


Met Gln Leu Met Asn Ser Ile Trp Asn Ile Cys Gly Lys Asp Val Val 
145                 150                 155                 160 


Thr Ala Phe Asp Leu Ser Pro Phe Lys Thr Ile Cys Asp Leu Gly Gly 
                165                 170                 175     


Cys Ser Gly Ala Leu Ala Lys Gln Cys Thr Ser Ala Tyr Pro Glu Cys 
            180                 185                 190         


Thr Val Thr Ile Phe Asp Leu Pro Lys Val Val Arg Thr Ser Arg Glu 
        195                 200                 205             


Asn Phe Phe Thr Glu Ala Asn Gln Arg Ile Gly Phe Cys Glu Gly Asp 
    210                 215                 220                 


Phe Phe Lys Asp Pro Leu Pro Glu Ala Asp Leu Tyr Val Leu Ala Arg 
225                 230                 235                 240 


Ile Leu His Asp Trp Thr Asp Gln Arg Cys Leu Glu Leu Leu Arg Arg 
                245                 250                 255     


Val His Gly Ala Cys Arg Pro Gly Gly Ser Val Leu Leu Val Glu Ala 
            260                 265                 270         


Leu Leu Tyr Glu Asp Gly Ser Gly Pro Leu Thr Ala Gln Leu Tyr Ser 
        275                 280                 285             


Leu Asn Met Leu Val Gln Thr Glu Gly Arg Glu Arg Ser Ala Ala Gln 
    290                 295                 300                 


Tyr Ala Ala Leu Leu Thr Ala Ala Gly Phe Ser Asn Val Gln His Arg 
305                 310                 315                 320 


Phe Thr Gly Lys Ile Tyr Asp Ala Val Leu Ala Arg Lys Glu Ala 
                325                 330                 335 


<210>  5
<211>  345
<212>  PRT
<213>  Macaca mulatta

<400>  5

Met Gly Ser Ser Gly Asp Asp Gly Tyr Arg Leu Leu Asn Glu Tyr Thr 
1               5                   10                  15      


Asn Gly Phe Met Val Ser Gln Val Leu Phe Ala Ala Cys Glu Leu Gly 
            20                  25                  30          


Val Phe Asp Leu Leu Ala Glu Ala Pro Gly Pro Leu Asp Val Ala Ala 
        35                  40                  45              


Val Ala Ala Gly Val Glu Ala Ser Ser His Gly Thr Glu Leu Leu Leu 
    50                  55                  60                  


Asp Thr Cys Val Ser Leu Lys Leu Leu Lys Val Glu Thr Arg Ala Gly 
65                  70                  75                  80  


Lys Ala Phe Tyr Gln Asn Thr Glu Leu Ser Ser Ala Tyr Leu Thr Arg 
                85                  90                  95      


Val Ser Pro Thr Ser Gln Cys Asn Leu Leu Lys Tyr Met Gly Arg Thr 
            100                 105                 110         


Ser Tyr Gly Cys Trp Gly His Leu Ala Asp Ala Val Arg Glu Gly Lys 
        115                 120                 125             


Asn Gln Tyr Leu Gln Thr Phe Gly Val Pro Ala Glu Asp Leu Phe Lys 
    130                 135                 140                 


Ala Ile Tyr Arg Ser Glu Gly Glu Arg Leu Gln Phe Met Gln Ala Leu 
145                 150                 155                 160 


Gln Glu Val Trp Ser Val Asn Gly Arg Ser Val Leu Thr Ala Phe Asp 
                165                 170                 175     


Leu Ser Gly Phe Pro Leu Met Cys Asp Leu Gly Gly Gly Pro Gly Ala 
            180                 185                 190         


Leu Ala Lys Glu Cys Leu Ser Leu Tyr Pro Gly Cys Lys Val Thr Val 
        195                 200                 205             


Phe Asp Val Pro Glu Val Val Arg Thr Ala Lys Gln His Phe Ser Phe 
    210                 215                 220                 


Pro Glu Glu Glu Glu Ile His Leu Gln Glu Gly Asp Phe Phe Lys Asp 
225                 230                 235                 240 


Pro Leu Pro Glu Ala Asp Leu Tyr Ile Leu Ala Arg Ile Leu His Asp 
                245                 250                 255     


Trp Ala Asp Gly Lys Cys Ser His Leu Leu Glu Arg Val Tyr His Thr 
            260                 265                 270         


Cys Lys Pro Gly Gly Gly Ile Leu Val Ile Glu Ser Leu Leu Asp Glu 
        275                 280                 285             


Asp Arg Arg Gly Pro Leu Leu Thr Gln Leu Tyr Ser Leu Asn Met Leu 
    290                 295                 300                 


Val Gln Thr Glu Gly Gln Glu Arg Thr Pro Thr His Tyr His Met Leu 
305                 310                 315                 320 


Leu Ser Ser Ala Gly Phe Arg Asp Phe Gln Phe Lys Lys Thr Gly Ala 
                325                 330                 335     


Ile Tyr Asp Ala Ile Leu Val Arg Lys 
            340                 345 


<210>  6
<211>  345
<212>  PRT
<213>  Elephantulus edwardii

<400>  6

Met Glu Gly Pro Gly Asp Arg Ala Phe Arg Leu Leu Asn Glu Tyr Ser 
1               5                   10                  15      


Ser Gly Phe Met Val Ser Gln Val Leu Phe Ala Ala Cys Glu Leu Gly 
            20                  25                  30          


Val Phe Asp Leu Leu Ala Gln Ala Pro Glu Pro Leu Asp Thr Ala Glu 
        35                  40                  45              


Leu Ala Thr Arg Leu Gly Thr Ser Leu His Gly Thr Glu Leu Leu Leu 
    50                  55                  60                  


Asp Val Cys Ala Ser Leu Glu Leu Leu Thr Val Glu Thr Lys Arg Asn 
65                  70                  75                  80  


Arg Ala Val Tyr Gln Asn Thr Asp Leu Ser Thr Thr Phe Leu Val Arg 
                85                  90                  95      


Thr Ser Pro Thr Cys Gln Leu His Met Leu Leu Tyr Leu Ser Arg Thr 
            100                 105                 110         


Thr Tyr Leu Cys Trp Gly His Leu Ala Ala Ala Val Arg Glu Gly Lys 
        115                 120                 125             


Asn Gln Tyr Lys Arg Ala Phe Gly Val Pro Ser Glu Gln Leu Phe Thr 
    130                 135                 140                 


Ala Ile Tyr Arg Ser Glu Ala Glu Arg Leu Leu Phe Met Arg Gly Leu 
145                 150                 155                 160 


Ala Glu Ile Trp Ser Val His Gly Val Gly Val Met Thr Ala Phe Asp 
                165                 170                 175     


Leu Ser Ala Phe Ser Val Ile Cys Asp Leu Gly Gly Ala Ser Gly Ala 
            180                 185                 190         


Leu Ala Arg Val Cys Ala Ser Leu Tyr Pro Asp Ser Ser Val Leu Val 
        195                 200                 205             


Leu Glu Val Pro Glu Val Val Arg Ala Ala Arg Ser Leu Phe Leu Ser 
    210                 215                 220                 


Thr Val Glu Ala Pro Val Ser Phe Arg Glu Gly Asp Phe Phe Lys Asp 
225                 230                 235                 240 


Pro Leu Pro Glu Ala Asp Leu Tyr Ile Leu Ala Arg Val Leu His Asp 
                245                 250                 255     


Trp Thr Asp Glu Lys Cys Ser Glu Leu Leu Ala Lys Ile His His Thr 
            260                 265                 270         


Cys Lys Pro Gly Gly Gly Ile Leu Val Val Glu Ser Val Leu Glu Glu 
        275                 280                 285             


Asp Arg Arg Gly Pro Leu Thr Thr Gln Leu Tyr Ser Leu Asn Met Leu 
    290                 295                 300                 


Val Gln Thr Glu Gly Arg Glu Arg Thr Pro Ala Glu Tyr Arg Ser Leu 
305                 310                 315                 320 


Ile Cys Ser Ala Gly Phe Gln Asp Phe Gln Leu Lys Lys Thr Gly Lys 
                325                 330                 335     


Ile Tyr Asp Val Ile Leu Ala Arg Lys 
            340                 345 


<210>  7
<211>  364
<212>  PRT
<213>  Oryza sativa

<400>  7

Met Ala Gln Asn Val Gln Glu Asn Glu Gln Val Met Ser Thr Glu Asp 
1               5                   10                  15      


Leu Leu Gln Ala Gln Ile Glu Leu Tyr His His Cys Leu Ala Phe Ile 
            20                  25                  30          


Lys Ser Met Ala Leu Arg Ala Ala Thr Asp Leu Arg Ile Pro Asp Ala 
        35                  40                  45              


Ile His Cys Asn Gly Gly Ala Ala Thr Leu Thr Asp Leu Ala Ala His 
    50                  55                  60                  


Val Gly Leu His Pro Thr Lys Leu Ser His Leu Arg Arg Leu Met Arg 
65                  70                  75                  80  


Val Leu Thr Leu Ser Gly Ile Phe Thr Val His Asp Gly Asp Gly Glu 
                85                  90                  95      


Ala Thr Tyr Thr Leu Thr Arg Val Ser Arg Leu Leu Leu Ser Asp Gly 
            100                 105                 110         


Val Glu Arg Thr His Gly Leu Ser Gln Met Val Arg Val Phe Val Asn 
        115                 120                 125             


Pro Val Ala Val Ala Ser Gln Phe Ser Leu His Glu Trp Phe Thr Val 
    130                 135                 140                 


Glu Lys Ala Ala Ala Val Ser Leu Phe Glu Val Ala His Gly Cys Thr 
145                 150                 155                 160 


Arg Trp Glu Met Ile Ala Asn Asp Ser Lys Asp Gly Ser Met Phe Asn 
                165                 170                 175     


Ala Gly Met Val Glu Asp Ser Ser Val Ala Met Asp Ile Ile Leu Arg 
            180                 185                 190         


Lys Ser Ser Asn Val Phe Arg Gly Ile Asn Ser Leu Val Asp Val Gly 
        195                 200                 205             


Gly Gly Tyr Gly Ala Val Ala Ala Ala Val Val Arg Ala Phe Pro Asp 
    210                 215                 220                 


Ile Lys Cys Thr Val Leu Asp Leu Pro His Ile Val Ala Lys Ala Pro 
225                 230                 235                 240 


Ser Asn Asn Asn Ile Gln Phe Val Gly Gly Asp Leu Phe Glu Phe Ile 
                245                 250                 255     


Pro Ala Ala Asp Val Val Leu Leu Lys Cys Ile Leu His Cys Trp Gln 
            260                 265                 270         


His Asp Asp Cys Val Lys Ile Met Arg Arg Cys Lys Glu Ala Ile Ser 
        275                 280                 285             


Ala Arg Asp Ala Gly Gly Lys Val Ile Leu Ile Glu Val Val Val Gly 
    290                 295                 300                 


Ile Gly Ser Asn Glu Thr Val Pro Lys Glu Met Gln Leu Leu Phe Asp 
305                 310                 315                 320 


Val Phe Met Met Tyr Thr Asp Gly Ile Glu Arg Glu Glu His Glu Trp 
                325                 330                 335     


Lys Lys Ile Phe Leu Glu Ala Gly Phe Ser Asp Tyr Lys Ile Ile Pro 
            340                 345                 350         


Val Leu Gly Val Arg Ser Ile Ile Glu Val Tyr Pro 
        355                 360                 


<210>  8
<211>  432
<212>  PRT
<213>  Rattus norvegicus

<400>  8

Met Ala Pro Gly Arg Glu Gly Glu Leu Asp Arg Asp Phe Arg Val Leu 
1               5                   10                  15      


Met Ser Leu Ala His Gly Phe Met Val Ser Gln Val Leu Phe Ala Ala 
            20                  25                  30          


Leu Asp Leu Gly Ile Phe Asp Leu Ala Ala Gln Gly Pro Val Ala Ala 
        35                  40                  45              


Glu Ala Val Ala Gln Thr Gly Gly Trp Ser Pro Arg Gly Thr Gln Leu 
    50                  55                  60                  


Leu Met Asp Ala Cys Thr Arg Leu Gly Leu Leu Arg Gly Ala Gly Asp 
65                  70                  75                  80  


Gly Ser Tyr Thr Asn Ser Ala Leu Ser Ser Thr Phe Leu Val Ser Gly 
                85                  90                  95      


Ser Pro Gln Ser Gln Arg Cys Met Leu Leu Tyr Leu Ala Gly Thr Thr 
            100                 105                 110         


Tyr Gly Cys Trp Ala His Leu Ala Ala Gly Val Arg Glu Gly Arg Asn 
        115                 120                 125             


Gln Tyr Ser Arg Ala Val Gly Ile Ser Ala Glu Asp Pro Phe Ser Ala 
    130                 135                 140                 


Ile Tyr Arg Ser Glu Pro Glu Arg Leu Leu Phe Met Arg Gly Leu Gln 
145                 150                 155                 160 


Glu Thr Trp Ser Leu Cys Gly Gly Arg Val Leu Thr Ala Phe Asp Leu 
                165                 170                 175     


Ser Arg Phe Arg Val Ile Cys Asp Leu Gly Gly Gly Ser Gly Ala Leu 
            180                 185                 190         


Ala Gln Glu Ala Ala Arg Leu Tyr Pro Gly Ser Ser Val Cys Val Phe 
        195                 200                 205             


Asp Leu Pro Asp Val Ile Ala Ala Ala Arg Thr His Phe Leu Ser Pro 
    210                 215                 220                 


Gly Ala Arg Pro Ser Val Arg Phe Val Ala Gly Asp Phe Phe Arg Ser 
225                 230                 235                 240 


Arg Leu Pro Arg Ala Asp Leu Phe Ile Leu Ala Arg Val Leu His Asp 
                245                 250                 255     


Trp Ala Asp Gly Ala Cys Val Glu Leu Leu Gly Arg Leu His Arg Ala 
            260                 265                 270         


Cys Arg Pro Gly Gly Ala Leu Leu Leu Val Glu Ala Val Leu Ala Lys 
        275                 280                 285             


Gly Gly Ala Gly Pro Leu Arg Ser Leu Leu Leu Ser Leu Asn Met Met 
    290                 295                 300                 


Leu Gln Ala Glu Gly Trp Glu Arg Gln Ala Ser Asp Tyr Arg Asn Leu 
305                 310                 315                 320 


Ala Thr Arg Ala Gly Phe Pro Arg Leu Gln Leu Arg Arg Pro Gly Gly 
                325                 330                 335     


Pro Tyr His Ala Met Leu Ala Arg Arg Gly Pro Arg Pro Gly Ile Ile 
            340                 345                 350         


Thr Gly Val Gly Ser Asn Thr Thr Gly Thr Gly Ser Phe Val Thr Gly 
        355                 360                 365             


Ile Arg Arg Asp Val Pro Gly Ala Arg Ser Asp Ala Ala Gly Thr Gly 
    370                 375                 380                 


Ser Gly Thr Gly Asn Thr Gly Ser Gly Ile Met Leu Gln Gly Glu Thr 
385                 390                 395                 400 


Leu Glu Ser Glu Val Ser Ala Pro Gln Ala Gly Ser Asp Val Gly Gly 
                405                 410                 415     


Ala Gly Asn Glu Pro Arg Ser Gly Thr Leu Lys Gln Gly Asp Trp Lys 
            420                 425                 430         


<210>  9
<211>  346
<212>  PRT
<213>  Gallus gallus

<400>  9

Met Asp Ser Thr Glu Asp Leu Asp Tyr Pro Gln Ile Ile Phe Gln Tyr 
1               5                   10                  15      


Ser Asn Gly Phe Leu Val Ser Lys Val Met Phe Thr Ala Cys Glu Leu 
            20                  25                  30          


Gly Val Phe Asp Leu Leu Leu Gln Ser Gly Arg Pro Leu Ser Leu Asp 
        35                  40                  45              


Val Ile Ala Ala Arg Leu Gly Thr Ser Ile Met Gly Met Glu Arg Leu 
    50                  55                  60                  


Leu Asp Ala Cys Val Gly Leu Lys Leu Leu Ala Val Glu Leu Arg Arg 
65                  70                  75                  80  


Glu Gly Ala Phe Tyr Arg Asn Thr Glu Ile Ser Asn Ile Tyr Leu Thr 
                85                  90                  95      


Lys Ser Ser Pro Lys Ser Gln Tyr His Ile Met Met Tyr Tyr Ser Asn 
            100                 105                 110         


Thr Val Tyr Leu Cys Trp His Tyr Leu Thr Asp Ala Val Arg Glu Gly 
        115                 120                 125             


Arg Asn Gln Tyr Glu Arg Ala Phe Gly Ile Ser Ser Lys Asp Leu Phe 
    130                 135                 140                 


Gly Ala Arg Tyr Arg Ser Glu Glu Glu Met Leu Lys Phe Leu Ala Gly 
145                 150                 155                 160 


Gln Asn Ser Ile Trp Ser Ile Cys Gly Arg Asp Val Leu Thr Ala Phe 
                165                 170                 175     


Asp Leu Ser Pro Phe Thr Gln Ile Tyr Asp Leu Gly Gly Gly Gly Gly 
            180                 185                 190         


Ala Leu Ala Gln Glu Cys Val Phe Leu Tyr Pro Asn Cys Thr Val Thr 
        195                 200                 205             


Ile Tyr Asp Leu Pro Lys Val Val Gln Val Ala Lys Glu Arg Leu Val 
    210                 215                 220                 


Pro Pro Glu Glu Arg Arg Ile Ala Phe His Glu Gly Asp Phe Phe Lys 
225                 230                 235                 240 


Asp Ser Ile Pro Glu Ala Asp Leu Tyr Ile Leu Ser Lys Ile Leu His 
                245                 250                 255     


Asp Trp Asp Asp Lys Lys Cys Arg Gln Leu Leu Ala Glu Val Tyr Lys 
            260                 265                 270         


Ala Cys Arg Pro Gly Gly Gly Val Leu Leu Val Glu Ser Leu Leu Ser 
        275                 280                 285             


Glu Asp Arg Ser Gly Pro Val Glu Thr Gln Leu Tyr Ser Leu Asn Met 
    290                 295                 300                 


Leu Val Gln Thr Glu Gly Lys Glu Arg Thr Ala Val Glu Tyr Ser Glu 
305                 310                 315                 320 


Leu Leu Gly Ala Ala Gly Phe Arg Glu Val Gln Val Arg Arg Thr Gly 
                325                 330                 335     


Lys Leu Tyr Asp Ala Val Leu Gly Arg Lys 
            340                 345     


<210>  10
<211>  341
<212>  PRT
<213>  Chromobacterium violaceum

<400>  10

Met Gly Tyr Ala Ala Pro Gln Ala Arg Gln Ser Asp Lys Lys Ile Phe 
1               5                   10                  15      


Asp Ile Tyr Phe Gly Phe Leu His Ser Tyr Ala Leu Leu Phe Ala Asp 
            20                  25                  30          


Glu Val Gly Leu Phe Asp Leu Leu Arg Cys Glu Ala Leu Thr Leu Asp 
        35                  40                  45              


Gln Val Ser Met Ala Thr Ser Leu Pro Phe Arg Ser Ser Gln Ala Leu 
    50                  55                  60                  


Leu Ser Leu Cys Ala Ser Leu Gly Leu Leu Glu Lys Arg Gly Glu Arg 
65                  70                  75                  80  


Phe Ala Leu Ser Ala Leu Ala Glu Gly Phe Leu Val Arg Glu Ala Glu 
                85                  90                  95      


Thr Ser Phe Cys Gly Val Leu Ala Ser Ala Arg Gly Gln Ala Ala Ala 
            100                 105                 110         


Phe Ser Tyr Asp Phe Phe Lys Ala Ser Leu Leu Lys Gly Glu Ser Gln 
        115                 120                 125             


Leu Phe Gly Gly Arg Asp Leu Phe Asp Asn Asn Ala Gln Asp Ser Glu 
    130                 135                 140                 


His Cys Glu Ile Phe Thr Arg Ala Met His Ser Lys Ser Lys Gly Pro 
145                 150                 155                 160 


Ala Gln Ala Trp Val Glu Lys Ile Asp Leu Ser Ala His Ala Cys Leu 
                165                 170                 175     


Leu Asp Val Gly Gly Gly Ser Gly Val His Ala Ile Ser Ala Leu Ala 
            180                 185                 190         


Arg Trp Pro Asn Leu Asn Ala Val Val Phe Asp Leu Pro Pro Val Cys 
        195                 200                 205             


Ala Ile Ala Asp Thr Phe Ile Glu Arg Tyr Gln Met Met Ala Arg Ala 
    210                 215                 220                 


Gln Thr His Gly Gly Asp Ile Trp Tyr Thr Asp Tyr Pro Phe Ala Asp 
225                 230                 235                 240 


Ala His Phe Tyr Ser Asp Ile Phe His Asp Trp Pro Leu Glu Arg Cys 
                245                 250                 255     


Arg Phe Leu Ala Arg Lys Ser Phe Asp Ala Leu Pro Ser Gly Gly Arg 
            260                 265                 270         


Ile Ile Leu His Glu Met Leu Phe Asn Thr Gln Lys Thr Gly Pro Arg 
        275                 280                 285             


Asn Val Ala Ala Tyr Asn Ala Asn Met Leu Leu Trp Thr Gln Gly Gln 
    290                 295                 300                 


Gln Leu Ser Glu Pro Glu Ala Ala Asp Leu Leu Gln Ala Ala Gly Phe 
305                 310                 315                 320 


Val Glu Ile Leu Ala Phe Pro Thr Gly Tyr Gly Asp Trp Ser Leu Val 
                325                 330                 335     


Thr Gly Val Lys Pro 
            340     


<210>  11
<211>  338
<212>  PRT
<213>  Desulfotomaculum kuznetsovii DSM 6115

<400>  11

Met Tyr Thr Gly Glu Thr Arg Phe Ser Pro Ser Gly Trp Tyr Ile Met 
1               5                   10                  15      


Asp Ile Cys Arg Gly His Trp Ala Ala Gln Val Leu Phe Thr Ala Val 
            20                  25                  30          


Asp Leu Gly Leu Phe Asp Ile Leu Ala Arg Gly Ala Gln Thr Pro Ala 
        35                  40                  45              


Arg Val Ala Ala Ala Leu Gly Thr His Pro Glu Ala Thr Ala Arg Leu 
    50                  55                  60                  


Leu Val Ala Leu Glu Gly Leu Gly Leu Val Lys Arg Glu Gly Glu Phe 
65                  70                  75                  80  


Tyr Arg Asn Ala Pro Leu Ala Gly Arg His Leu Val Arg Gly Gly Asp 
                85                  90                  95      


Ala Tyr Leu Gly His Ala Val His His Phe Ala Asn Leu Ala Glu Gly 
            100                 105                 110         


Trp Ser Arg Leu Gly Glu Ala Val Arg Thr Gly Arg Pro Val Gly Phe 
        115                 120                 125             


Glu Ala Val Glu Arg Ala Asn Tyr Glu Glu Arg Leu Arg Asp Tyr Ile 
    130                 135                 140                 


Leu Ala Met Gly Asp Gln Ala Arg Leu Lys Ala Asp Arg Leu Ala Ala 
145                 150                 155                 160 


Ala Leu Asp Leu Ser Gly Cys Glu Arg Ile Leu Asp Leu Gly Gly Gly 
                165                 170                 175     


Pro Gly Val His Thr Val Ala Leu Leu Lys Lys Glu Pro Arg Ala Arg 
            180                 185                 190         


Ala Thr Ile Leu Asp Leu Ala Pro Thr Leu Lys Ile Thr Arg Glu Leu 
        195                 200                 205             


Ile Glu Ala Ala Gly Met Met Glu Arg Val Glu Leu Cys Ala Gly Asp 
    210                 215                 220                 


Phe Thr Arg Asp Glu Leu Gly Glu Gly Val Tyr Asp Leu Val Leu Ala 
225                 230                 235                 240 


Ser Asn Val Val His Ile Tyr Asp Ala Ala Thr Asn Arg Gln Ile Met 
                245                 250                 255     


Asp Arg Val Phe Arg Ala Leu Arg Pro Gly Gly Gln Val Val Ile His 
            260                 265                 270         


Asp Tyr Val Leu Ala Glu Glu Pro Ser Leu Glu Ala Ala Leu Phe Asp 
        275                 280                 285             


Leu Asn Met Leu Val Gly Thr Leu Thr Gly Arg Val Tyr Gly Val Gln 
    290                 295                 300                 


Glu Met Gly Ser Trp Leu Glu Asp Ala Gly Phe Val Asp Val Thr Tyr 
305                 310                 315                 320 


His Pro Leu Thr Pro Gly Ser Gly Leu Leu Lys Gly Arg Lys Trp Asn 
                325                 330                 335     


Asp Lys 
        


<210>  12
<211>  266
<212>  PRT
<213>  Xenopus (Silurana) tropicalis

<400>  12

Met Lys Asn Asn Glu Ala Phe Phe Ser Asn Thr Asp Val Ser Asn Met 
1               5                   10                  15      


Tyr Leu Val Lys Ser Ser Pro Arg Ser Phe Tyr Gln Met Met Met Tyr 
            20                  25                  30          


Tyr Ser Lys Thr Ile Tyr Met Cys Trp His Phe Leu Pro Asp Ala Ile 
        35                  40                  45              


Arg Glu Gly Lys Arg Gln Tyr Glu Arg Ala Phe Gly Ile Thr Ser Glu 
    50                  55                  60                  


Asp Ile Phe Lys Asp Leu Tyr Arg Ser Glu Glu Glu Thr Val Ser Phe 
65                  70                  75                  80  


Met His His Met Glu Ser Ile Trp His Ile Cys Gly Lys Asp Val Leu 
                85                  90                  95      


Ala Ala Phe Asp Leu Ser Ser Phe Lys Glu Ile Cys Asp Ile Gly Gly 
            100                 105                 110         


Cys Ser Gly Gly Leu Ala Lys His Phe Leu Ser Leu Tyr Pro Ser Ser 
        115                 120                 125             


Ser Val Thr Ile Met Asp Leu Pro Glu Val Val Gln Met Ala Lys Lys 
    130                 135                 140                 


His Phe Ile Thr Asp Gly Asp Ile Val Phe Leu Glu Asp Phe Phe Asn 
145                 150                 155                 160 


Asp Pro Leu Pro Glu Ser Asp Leu Tyr Ile Leu Ala Arg Ile Ile His 
                165                 170                 175     


Asp Trp Thr Glu Asp Lys Cys Leu Arg Leu Leu Asn Lys Ile Tyr Lys 
            180                 185                 190         


Ser Cys Arg Pro Gly Gly Gly Val Leu Leu Val Glu Ala Leu Leu Asn 
        195                 200                 205             


Glu Asp Arg Ser Gly Pro Leu Ser Ser Gln Met Phe Ser Leu Asn Met 
    210                 215                 220                 


Leu Leu Gln Thr Glu Gly Lys Glu Arg Ser Ala Ser Glu Tyr His Lys 
225                 230                 235                 240 


Leu Leu Ala Asp Ser Gly Phe Arg Glu Ile Gln Val Lys Ala Thr Gly 
                245                 250                 255     


Lys Phe Tyr Asp Ala Val Leu Gly Lys Lys 
            260                 265     


<210>  13
<211>  341
<212>  PRT
<213>  Pseudomonas fluorescens

<400>  13

Met Asp Ser Thr Val His Thr Glu His His Ser Asp Lys Gln Ile Phe 
1               5                   10                  15      


Asp Ile Tyr Phe Gly Phe Ile Asn Thr Tyr Thr Leu Phe Phe Ala Asp 
            20                  25                  30          


Glu Val Lys Leu Phe Asp Leu Leu Glu Gly Lys Ala Leu Arg Leu Gly 
        35                  40                  45              


Glu Ile Gly Ser Ala Leu Glu Leu Ala Pro Arg Ala Ala Gln Ala Leu 
    50                  55                  60                  


Val Ala Met Cys Thr Ser Gln Gly Leu Leu Glu Lys Ser Gly Glu Cys 
65                  70                  75                  80  


Tyr Gly Leu Thr Ser Leu Ala Gln Ala Phe Leu Thr Arg Lys Ser Glu 
                85                  90                  95      


Thr Ser Phe Ser Gly Val Leu Gln Ser Ala Arg His Lys Glu Asp Ala 
            100                 105                 110         


Phe Ser Tyr Ala Phe Phe Lys Glu Ser Met Leu Ser Gly Glu Ser Gly 
        115                 120                 125             


Leu Phe Gly Glu Thr Asp Leu Phe Glu Asn Asn Ala Gln Asp Gln Leu 
    130                 135                 140                 


His Ser Glu Ile Phe Thr Lys Ala Met His Ser Lys Ser Lys Gly Pro 
145                 150                 155                 160 


Ala Arg Ala Trp Ser Gly Arg Ile Asp Leu Ser Gly Tyr Thr Cys Leu 
                165                 170                 175     


Leu Asp Val Gly Gly Gly Ser Gly Val His Ser Ile Cys Ala Leu Glu 
            180                 185                 190         


Lys Trp Pro Glu Leu Asn Ala Val Ile Phe Asp Leu Pro Tyr Val Cys 
        195                 200                 205             


Asp Ile Ala Asp Thr Tyr Val Glu Gln Tyr Arg Met Ala Gly Arg Ile 
    210                 215                 220                 


Thr Thr His Lys Gly Asp Ile Trp Ala Ser Glu Tyr Pro Ala Ala Asp 
225                 230                 235                 240 


Val His Leu Tyr Ser Asp Ile Phe His Asp Trp Pro Leu Asp Lys Cys 
                245                 250                 255     


Leu Phe Leu Ala Lys Lys Ser Phe Asp Ala Leu Pro Ser Gly Gly Arg 
            260                 265                 270         


Ile Ile Leu His Glu Met Phe Phe Asn Lys Asp Lys Thr Gly Pro His 
        275                 280                 285             


Asn Val Ala Ala Tyr Asn Ala Asn Met Leu Leu Trp Thr Gln Gly Gln 
    290                 295                 300                 


Gln Leu Ser Glu Thr Glu Ile Arg Glu Leu Leu Thr Ile Ala Gly Phe 
305                 310                 315                 320 


Arg Asp Ile Thr Val Ser Arg Thr Gln Tyr Gly Asp Trp Ser Leu Ala 
                325                 330                 335     


Thr Gly Ile Lys Tyr 
            340     


<210>  14
<211>  339
<212>  PRT
<213>  Candidatus Solibacter usitatus

<400>  14

Met Thr Pro Asn Leu Pro Asp Ala Ser Pro Val Leu Asp Leu Ile Glu 
1               5                   10                  15      


Ala Phe Arg Arg Ser Lys Thr Met Phe Thr Ala Leu Ser Met Gly Val 
            20                  25                  30          


Phe Asp Thr Leu His Glu Ala Pro Ser Asn Ala Glu Thr Leu Ala Ala 
        35                  40                  45              


Lys Leu Gly Ala Asn Ala Gly Ala Leu Ala Arg Leu Leu Asp Gly Cys 
    50                  55                  60                  


Ala Ala Leu Gln Leu Leu Gln Lys Arg Asp Gly Leu Tyr Glu Asn Ala 
65                  70                  75                  80  


Pro Leu Ser Glu Thr Tyr Leu Tyr Ser Gly Ser Pro His Ser Met Ser 
                85                  90                  95      


Gly Tyr Val Arg Tyr Ser Glu Gln Ala Leu Tyr Pro Met Trp Gly Asn 
            100                 105                 110         


Leu Ala Asp Ala Val Arg Glu Gly Thr Pro Arg Trp Ser Gln Asn Phe 
        115                 120                 125             


Gly Ile Asp Gly Pro Ile Phe Ser Ala Phe Phe Arg Thr Pro Glu Ala 
    130                 135                 140                 


Met Arg Asp Phe Leu Met Gly Met His Gly Phe Gly Met Leu Thr Ser 
145                 150                 155                 160 


Pro Lys Val Ala Ala Ala Phe Asp Leu Ser Arg Phe Arg Arg Leu Val 
                165                 170                 175     


Asp Leu Gly Gly Ala Thr Gly His Leu Thr Ile Ala Ala Cys Glu Leu 
            180                 185                 190         


Tyr Pro Glu Met Arg Gly Val Val Phe Asp Leu Pro Gln Ala Ala Gly 
        195                 200                 205             


Met Ala Arg Glu Leu Val Glu Arg Ser Ala Ala Ser Ala Arg Val Glu 
    210                 215                 220                 


Ile Val Ser Gly Asp Phe Phe Ala Asp Glu Leu Pro Glu Ala Asp Leu 
225                 230                 235                 240 


Tyr Tyr Thr Gly Arg Ile Leu His Asp Trp Ser Glu Glu Lys Ile Asp 
                245                 250                 255     


Arg Leu Leu Ala Arg Ile Val Gln Arg Leu Pro Ser Gly Gly Ala Leu 
            260                 265                 270         


Leu Ile Gly Glu Lys Leu Leu Ala Glu Asp Gly Val Gly Pro Val Pro 
        275                 280                 285             


Ala Asn Met Gln Ser Leu Asn Met Leu Val Val Thr Glu Gly Arg Glu 
    290                 295                 300                 


Arg Ser Leu Gly Glu Tyr Arg Gly Leu Leu Met Arg Ala Gly Phe Ala 
305                 310                 315                 320 


Ser Val Glu Gly Arg His Thr Gly Val Ala Leu Asp Ala Ile Leu Ala 
                325                 330                 335     


Ile Lys Ala 
            


<210>  15
<211>  221
<212>  PRT
<213>  Fenneropenaeus chinensis

<400>  15

Met Ser Ser Leu Lys Ser Tyr Asp Asn Thr Asp Pro Leu Val Gln Tyr 
1               5                   10                  15      


Cys Val Asn His Ser Leu Arg Leu Thr Asp Val Gln Lys Arg Leu Asn 
            20                  25                  30          


Asp Ala Thr Leu Gln His Arg Arg Ala Ala Met Leu Gly Ala Pro Glu 
        35                  40                  45              


Val Leu Gln Leu Asn Ala Asn Ile Met Gln Ala Ile Gly Ala Lys Lys 
    50                  55                  60                  


Val Leu Asp Ile Gly Val Phe Thr Gly Ala Ser Ser Leu Ser Ala Ala 
65                  70                  75                  80  


Leu Ala Leu Pro Pro Asn Gly Lys Val Tyr Ala Leu Asp Ile Ser Glu 
                85                  90                  95      


Glu Phe Thr Asn Ile Gly Lys Pro Tyr Trp Glu Glu Ala Gly Val Ser 
            100                 105                 110         


Asn Lys Ile Ser Leu His Ile Ala Pro Ala Ala Glu Thr Leu Gln Lys 
        115                 120                 125             


Phe Ile Asp Ala Gly Glu Ala Gly Thr Phe Asp Tyr Ala Phe Ile Asp 
    130                 135                 140                 


Ala Asp Lys Glu Ser Tyr Asp Arg Tyr Tyr Glu Leu Cys Leu Ile Leu 
145                 150                 155                 160 


Leu Arg Pro Gly Gly Val Ile Ala Phe Asp Asn Thr Leu Trp Asp Gly 
                165                 170                 175     


Ala Val Ile Asp Pro Thr Asp Gln Lys Pro Gly Thr Leu Ala Ile Arg 
            180                 185                 190         


Lys Met Asn Glu Lys Leu Lys Asp Asp Gln Arg Ile Asn Ile Ser Phe 
        195                 200                 205             


Leu Arg Ile Gly Asp Gly Leu Ser Leu Cys Phe Lys Lys 
    210                 215                 220     


<210>  16
<211>  363
<212>  PRT
<213>  Arabidopsis thaliana

<400>  16

Met Gly Ser Thr Ala Glu Thr Gln Leu Thr Pro Val Gln Val Thr Asp 
1               5                   10                  15      


Asp Glu Ala Ala Leu Phe Ala Met Gln Leu Ala Ser Ala Ser Val Leu 
            20                  25                  30          


Pro Met Ala Leu Lys Ser Ala Leu Glu Leu Asp Leu Leu Glu Ile Met 
        35                  40                  45              


Ala Lys Asn Gly Ser Pro Met Ser Pro Thr Glu Ile Ala Ser Lys Leu 
    50                  55                  60                  


Pro Thr Lys Asn Pro Glu Ala Pro Val Met Leu Asp Arg Ile Leu Arg 
65                  70                  75                  80  


Leu Leu Thr Ser Tyr Ser Val Leu Thr Cys Ser Asn Arg Lys Leu Ser 
                85                  90                  95      


Gly Asp Gly Val Glu Arg Ile Tyr Gly Leu Gly Pro Val Cys Lys Tyr 
            100                 105                 110         


Leu Thr Lys Asn Glu Asp Gly Val Ser Ile Ala Ala Leu Cys Leu Met 
        115                 120                 125             


Asn Gln Asp Lys Val Leu Met Glu Ser Trp Tyr His Leu Lys Asp Ala 
    130                 135                 140                 


Ile Leu Asp Gly Gly Ile Pro Phe Asn Lys Ala Tyr Gly Met Ser Ala 
145                 150                 155                 160 


Phe Glu Tyr His Gly Thr Asp Pro Arg Phe Asn Lys Val Phe Asn Asn 
                165                 170                 175     


Gly Met Ser Asn His Ser Thr Ile Thr Met Lys Lys Ile Leu Glu Thr 
            180                 185                 190         


Tyr Lys Gly Phe Glu Gly Leu Thr Ser Leu Val Asp Val Gly Gly Gly 
        195                 200                 205             


Ile Gly Ala Thr Leu Lys Met Ile Val Ser Lys Tyr Pro Asn Leu Lys 
    210                 215                 220                 


Gly Ile Asn Phe Asp Leu Pro His Val Ile Glu Asp Ala Pro Ser His 
225                 230                 235                 240 


Pro Gly Ile Glu His Val Gly Gly Asp Met Phe Val Ser Val Pro Lys 
                245                 250                 255     


Gly Asp Ala Ile Phe Met Lys Trp Ile Cys His Asp Trp Ser Asp Glu 
            260                 265                 270         


His Cys Val Lys Phe Leu Lys Asn Cys Tyr Glu Ser Leu Pro Glu Asp 
        275                 280                 285             


Gly Lys Val Ile Leu Ala Glu Cys Ile Leu Pro Glu Thr Pro Asp Ser 
    290                 295                 300                 


Ser Leu Ser Thr Lys Gln Val Val His Val Asp Cys Ile Met Leu Ala 
305                 310                 315                 320 


His Asn Pro Gly Gly Lys Glu Arg Thr Glu Lys Glu Phe Glu Ala Leu 
                325                 330                 335     


Ala Lys Ala Ser Gly Phe Lys Gly Ile Lys Val Val Cys Asp Ala Phe 
            340                 345                 350         


Gly Val Asn Leu Ile Glu Leu Leu Lys Lys Leu 
        355                 360             


<210>  17
<211>  496
<212>  PRT
<213>  Homo sapiens

<400>  17

Met Gln Pro Ala Met Met Met Phe Ser Ser Lys Tyr Trp Ala Arg Arg 
1               5                   10                  15      


Gly Phe Ser Leu Asp Ser Ala Val Pro Glu Glu His Gln Leu Leu Gly 
            20                  25                  30          


Ser Ser Thr Ala Ser Thr Phe Leu Lys Leu Asn Lys Pro Asn Ser Gly 
        35                  40                  45              


Lys Asn Asp Asp Lys Gly Asn Lys Gly Ser Ser Lys Arg Glu Ala Ala 
    50                  55                  60                  


Thr Glu Ser Gly Lys Thr Ala Val Val Phe Ser Leu Lys Asn Glu Val 
65                  70                  75                  80  


Gly Gly Leu Val Lys Ala Leu Arg Leu Phe Gln Glu Lys Arg Val Asn 
                85                  90                  95      


Met Val His Ile Glu Ser Arg Lys Ser Arg Arg Arg Ser Ser Glu Val 
            100                 105                 110         


Glu Ile Phe Val Asp Cys Glu Cys Gly Lys Thr Glu Phe Asn Glu Leu 
        115                 120                 125             


Ile Gln Leu Leu Lys Phe Gln Thr Thr Ile Val Thr Leu Asn Pro Pro 
    130                 135                 140                 


Glu Asn Ile Trp Thr Glu Glu Glu Glu Leu Glu Asp Val Pro Trp Phe 
145                 150                 155                 160 


Pro Arg Lys Ile Ser Glu Leu Asp Lys Cys Ser His Arg Val Leu Met 
                165                 170                 175     


Tyr Gly Ser Glu Leu Asp Ala Asp His Pro Gly Phe Lys Asp Asn Val 
            180                 185                 190         


Tyr Arg Gln Arg Arg Lys Tyr Phe Val Asp Val Ala Met Gly Tyr Lys 
        195                 200                 205             


Tyr Gly Gln Pro Ile Pro Arg Val Glu Tyr Thr Glu Glu Glu Thr Lys 
    210                 215                 220                 


Thr Trp Gly Val Val Phe Arg Glu Leu Ser Lys Leu Tyr Pro Thr His 
225                 230                 235                 240 


Ala Cys Arg Glu Tyr Leu Lys Asn Phe Pro Leu Leu Thr Lys Tyr Cys 
                245                 250                 255     


Gly Tyr Arg Glu Asp Asn Val Pro Gln Leu Glu Asp Val Ser Met Phe 
            260                 265                 270         


Leu Lys Glu Arg Ser Gly Phe Thr Val Arg Pro Val Ala Gly Tyr Leu 
        275                 280                 285             


Ser Pro Arg Asp Phe Leu Ala Gly Leu Ala Tyr Arg Val Phe His Cys 
    290                 295                 300                 


Thr Gln Tyr Ile Arg His Gly Ser Asp Pro Leu Tyr Thr Pro Glu Pro 
305                 310                 315                 320 


Asp Thr Cys His Glu Leu Leu Gly His Val Pro Leu Leu Ala Asp Pro 
                325                 330                 335     


Lys Phe Ala Gln Phe Ser Gln Glu Ile Gly Leu Ala Ser Leu Gly Ala 
            340                 345                 350         


Ser Asp Glu Asp Val Gln Lys Leu Ala Thr Cys Tyr Phe Phe Thr Ile 
        355                 360                 365             


Glu Phe Gly Leu Cys Lys Gln Glu Gly Gln Leu Arg Ala Tyr Gly Ala 
    370                 375                 380                 


Gly Leu Leu Ser Ser Ile Gly Glu Leu Lys His Ala Leu Ser Asp Lys 
385                 390                 395                 400 


Ala Cys Val Lys Ala Phe Asp Pro Lys Thr Thr Cys Leu Gln Glu Cys 
                405                 410                 415     


Leu Ile Thr Thr Phe Gln Glu Ala Tyr Phe Val Ser Glu Ser Phe Glu 
            420                 425                 430         


Glu Ala Lys Glu Lys Met Arg Asp Phe Ala Lys Ser Ile Thr Arg Pro 
        435                 440                 445             


Phe Ser Val Tyr Phe Asn Pro Tyr Thr Gln Ser Ile Glu Ile Leu Lys 
    450                 455                 460                 


Asp Thr Arg Ser Ile Glu Asn Val Val Gln Asp Leu Arg Ser Asp Leu 
465                 470                 475                 480 


Asn Thr Val Cys Asp Ala Leu Asn Lys Met Asn Gln Tyr Leu Gly Ile 
                485                 490                 495     


<210>  18
<211>  448
<212>  PRT
<213>  Homo sapiens

<400>  18

Met Asp Asp Lys Gly Asn Lys Gly Ser Ser Lys Arg Glu Ala Ala Thr 
1               5                   10                  15      


Glu Ser Gly Lys Thr Ala Val Val Phe Ser Leu Lys Asn Glu Val Gly 
            20                  25                  30          


Gly Leu Val Lys Ala Leu Arg Leu Phe Gln Glu Lys Arg Val Asn Met 
        35                  40                  45              


Val His Ile Glu Ser Arg Lys Ser Arg Arg Arg Ser Ser Glu Val Glu 
    50                  55                  60                  


Ile Phe Val Asp Cys Glu Cys Gly Lys Thr Glu Phe Asn Glu Leu Ile 
65                  70                  75                  80  


Gln Leu Leu Lys Phe Gln Thr Thr Ile Val Thr Leu Asn Pro Pro Glu 
                85                  90                  95      


Asn Ile Trp Thr Glu Glu Glu Glu Leu Glu Asp Val Pro Trp Phe Pro 
            100                 105                 110         


Arg Lys Ile Ser Glu Leu Asp Lys Cys Ser His Arg Val Leu Met Tyr 
        115                 120                 125             


Gly Ser Glu Leu Asp Ala Asp His Pro Gly Phe Lys Asp Asn Val Tyr 
    130                 135                 140                 


Arg Gln Arg Arg Lys Tyr Phe Val Asp Val Ala Met Gly Tyr Lys Tyr 
145                 150                 155                 160 


Gly Gln Pro Ile Pro Arg Val Glu Tyr Thr Glu Glu Glu Thr Lys Thr 
                165                 170                 175     


Trp Gly Val Val Phe Arg Glu Leu Ser Lys Leu Tyr Pro Thr His Ala 
            180                 185                 190         


Cys Arg Glu Tyr Leu Lys Asn Phe Pro Leu Leu Thr Lys Tyr Cys Gly 
        195                 200                 205             


Tyr Arg Glu Asp Asn Val Pro Gln Leu Glu Asp Val Ser Met Phe Leu 
    210                 215                 220                 


Lys Glu Arg Ser Gly Phe Thr Val Arg Pro Val Ala Gly Tyr Leu Ser 
225                 230                 235                 240 


Pro Arg Asp Phe Leu Ala Gly Leu Ala Tyr Arg Val Phe His Cys Thr 
                245                 250                 255     


Gln Tyr Ile Arg His Gly Ser Asp Pro Leu Tyr Thr Pro Glu Pro Asp 
            260                 265                 270         


Thr Cys His Glu Leu Leu Gly His Val Pro Leu Leu Ala Asp Pro Lys 
        275                 280                 285             


Phe Ala Gln Phe Ser Gln Glu Ile Gly Leu Ala Ser Leu Gly Ala Ser 
    290                 295                 300                 


Asp Glu Asp Val Gln Lys Leu Ala Thr Cys Tyr Phe Phe Thr Ile Glu 
305                 310                 315                 320 


Phe Gly Leu Cys Lys Gln Glu Gly Gln Leu Arg Ala Tyr Gly Ala Gly 
                325                 330                 335     


Leu Leu Ser Ser Ile Gly Glu Leu Lys His Ala Leu Ser Asp Lys Ala 
            340                 345                 350         


Cys Val Lys Ala Phe Asp Pro Lys Thr Thr Cys Leu Gln Glu Cys Leu 
        355                 360                 365             


Ile Thr Thr Phe Gln Glu Ala Tyr Phe Val Ser Glu Ser Phe Glu Glu 
    370                 375                 380                 


Ala Lys Glu Lys Met Arg Asp Phe Ala Lys Ser Ile Thr Arg Pro Phe 
385                 390                 395                 400 


Ser Val Tyr Phe Asn Pro Tyr Thr Gln Ser Ile Glu Ile Leu Lys Asp 
                405                 410                 415     


Thr Arg Ser Ile Glu Asn Val Val Gln Asp Leu Arg Ile Asn Arg Val 
            420                 425                 430         


His Ser Ser Ala Leu Thr Glu Lys Glu Gly Val Arg Gln Pro Glu Val 
        435                 440                 445             


<210>  19
<211>  428
<212>  PRT
<213>  Homo sapiens

<400>  19

Met Asp Asp Lys Gly Asn Lys Gly Ser Ser Lys Arg Glu Ala Ala Thr 
1               5                   10                  15      


Glu Ser Gly Lys Thr Ala Val Val Phe Ser Leu Lys Asn Glu Val Gly 
            20                  25                  30          


Gly Leu Val Lys Ala Leu Arg Leu Phe Gln Glu Lys Arg Val Asn Met 
        35                  40                  45              


Val His Ile Glu Ser Arg Lys Ser Arg Arg Arg Ser Ser Glu Val Glu 
    50                  55                  60                  


Ile Phe Val Asp Cys Glu Cys Gly Lys Thr Glu Phe Asn Glu Leu Ile 
65                  70                  75                  80  


Gln Leu Leu Lys Phe Gln Thr Thr Ile Val Thr Leu Asn Pro Pro Glu 
                85                  90                  95      


Asn Ile Trp Thr Glu Glu Glu Glu Leu Glu Asp Val Pro Trp Phe Pro 
            100                 105                 110         


Arg Lys Ile Ser Glu Leu Asp Lys Cys Ser His Arg Val Leu Met Tyr 
        115                 120                 125             


Gly Ser Glu Leu Asp Ala Asp His Pro Gly Phe Lys Asp Asn Val Tyr 
    130                 135                 140                 


Arg Gln Arg Arg Lys Tyr Phe Val Asp Val Ala Met Gly Tyr Lys Tyr 
145                 150                 155                 160 


Gly Gln Pro Ile Pro Arg Val Glu Tyr Thr Glu Glu Glu Thr Lys Thr 
                165                 170                 175     


Trp Gly Val Val Phe Arg Glu Leu Ser Lys Leu Tyr Pro Thr His Ala 
            180                 185                 190         


Cys Arg Glu Tyr Leu Lys Asn Phe Pro Leu Leu Thr Lys Tyr Cys Gly 
        195                 200                 205             


Tyr Arg Glu Asp Asn Val Pro Gln Leu Glu Asp Val Ser Met Phe Leu 
    210                 215                 220                 


Lys Glu Arg Ser Gly Phe Thr Val Arg Pro Val Ala Gly Tyr Leu Ser 
225                 230                 235                 240 


Pro Arg Asp Phe Leu Ala Gly Leu Ala Tyr Arg Val Phe His Cys Thr 
                245                 250                 255     


Gln Tyr Ile Arg His Gly Ser Asp Pro Leu Tyr Thr Pro Glu Pro Asp 
            260                 265                 270         


Thr Cys His Glu Leu Leu Gly His Val Pro Leu Leu Ala Asp Pro Lys 
        275                 280                 285             


Phe Ala Gln Phe Ser Gln Glu Ile Gly Leu Ala Ser Leu Gly Ala Ser 
    290                 295                 300                 


Asp Glu Asp Val Gln Lys Leu Ala Thr Cys Tyr Phe Phe Thr Ile Glu 
305                 310                 315                 320 


Phe Gly Leu Cys Lys Gln Glu Gly Gln Leu Arg Ala Tyr Gly Ala Gly 
                325                 330                 335     


Leu Leu Ser Ser Ile Gly Glu Leu Lys His Ala Leu Ser Asp Lys Ala 
            340                 345                 350         


Cys Val Lys Ala Phe Asp Pro Lys Thr Thr Cys Leu Gln Glu Cys Leu 
        355                 360                 365             


Ile Thr Thr Phe Gln Glu Ala Tyr Phe Val Ser Glu Ser Phe Glu Glu 
    370                 375                 380                 


Ala Lys Glu Lys Met Arg Asp Phe Ala Lys Ser Ile Thr Arg Pro Phe 
385                 390                 395                 400 


Ser Val Tyr Phe Asn Pro Tyr Thr Gln Ser Ile Glu Ile Leu Lys Asp 
                405                 410                 415     


Thr Arg Ser Ile Glu Asn Val Val Gln Asp Leu Arg 
            420                 425             


<210>  20
<211>  315
<212>  PRT
<213>  Homo sapiens

<400>  20

Met Glu Leu Glu Asp Val Pro Trp Phe Pro Arg Lys Ile Ser Glu Leu 
1               5                   10                  15      


Asp Lys Cys Ser His Arg Val Leu Met Tyr Gly Ser Glu Leu Asp Ala 
            20                  25                  30          


Asp His Pro Gly Phe Lys Asp Asn Val Tyr Arg Gln Arg Arg Lys Tyr 
        35                  40                  45              


Phe Val Asp Val Ala Met Gly Tyr Lys Tyr Gly Gln Pro Ile Pro Arg 
    50                  55                  60                  


Val Glu Tyr Thr Glu Glu Glu Thr Lys Thr Trp Gly Val Val Phe Arg 
65                  70                  75                  80  


Glu Leu Ser Lys Leu Tyr Pro Thr His Ala Cys Arg Glu Tyr Leu Lys 
                85                  90                  95      


Asn Phe Pro Leu Leu Thr Lys Tyr Cys Gly Tyr Arg Glu Asp Asn Val 
            100                 105                 110         


Pro Gln Leu Glu Asp Val Ser Met Phe Leu Lys Glu Arg Ser Gly Phe 
        115                 120                 125             


Thr Val Arg Pro Val Ala Gly Tyr Leu Ser Pro Arg Asp Phe Leu Ala 
    130                 135                 140                 


Gly Leu Ala Tyr Arg Val Phe His Cys Thr Gln Tyr Ile Arg His Gly 
145                 150                 155                 160 


Ser Asp Pro Leu Tyr Thr Pro Glu Pro Asp Thr Cys His Glu Leu Leu 
                165                 170                 175     


Gly His Val Pro Leu Leu Ala Asp Pro Lys Phe Ala Gln Phe Ser Gln 
            180                 185                 190         


Glu Ile Gly Leu Ala Ser Leu Gly Ala Ser Asp Glu Asp Val Gln Lys 
        195                 200                 205             


Leu Ala Thr Cys Tyr Phe Phe Thr Ile Glu Phe Gly Leu Cys Lys Gln 
    210                 215                 220                 


Glu Gly Gln Leu Arg Ala Tyr Gly Ala Gly Leu Leu Ser Ser Ile Gly 
225                 230                 235                 240 


Glu Leu Lys His Ala Leu Ser Asp Lys Ala Cys Val Lys Ala Phe Asp 
                245                 250                 255     


Pro Lys Thr Thr Cys Leu Gln Glu Cys Leu Ile Thr Thr Phe Gln Glu 
            260                 265                 270         


Ala Tyr Phe Val Ser Glu Ser Phe Glu Glu Ala Lys Glu Lys Met Arg 
        275                 280                 285             


Asp Phe Ala Lys Ser Ile Thr Arg Pro Phe Ser Val Tyr Phe Asn Pro 
    290                 295                 300                 


Tyr Thr Gln Ser Ile Glu Ile Leu Lys Asp Thr 
305                 310                 315 


