                         SEQUENCE LISTING

<110>  INSERM
 
<120>  METHODS AND PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF 
       PULMONARY BACTERIAL INFECTIONS

<130>  BIO15531

<160>  11    

<170>  PatentIn version 3.5

<210>  1
<211>  311
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Gln Thr Phe Thr Met Val Leu Glu Glu Ile Trp Thr Ser Leu Phe 
1               5                   10                  15      


Met Trp Phe Phe Tyr Ala Leu Ile Pro Cys Leu Leu Thr Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Pro Ala Pro Gln Asn Leu Ser Val Leu Ser Thr Asn Met 
        35                  40                  45              


Lys His Leu Leu Met Trp Ser Pro Val Ile Ala Pro Gly Glu Thr Val 
    50                  55                  60                  


Tyr Tyr Ser Val Glu Tyr Gln Gly Glu Tyr Glu Ser Leu Tyr Thr Ser 
65                  70                  75                  80  


His Ile Trp Ile Pro Ser Ser Trp Cys Ser Leu Thr Glu Gly Pro Glu 
                85                  90                  95      


Cys Asp Val Thr Asp Asp Ile Thr Ala Thr Val Pro Tyr Asn Leu Arg 
            100                 105                 110         


Val Arg Ala Thr Leu Gly Ser Gln Thr Ser Ala Trp Ser Ile Leu Lys 
        115                 120                 125             


His Pro Phe Asn Arg Asn Ser Thr Ile Leu Thr Arg Pro Gly Met Glu 
    130                 135                 140                 


Ile Thr Lys Asp Gly Phe His Leu Val Ile Glu Leu Glu Asp Leu Gly 
145                 150                 155                 160 


Pro Gln Phe Glu Phe Leu Val Ala Tyr Trp Arg Arg Glu Pro Gly Ala 
                165                 170                 175     


Glu Glu His Val Lys Met Val Arg Ser Gly Gly Ile Pro Val His Leu 
            180                 185                 190         


Glu Thr Met Glu Pro Gly Ala Ala Tyr Cys Val Lys Ala Gln Thr Phe 
        195                 200                 205             


Val Lys Ala Ile Gly Arg Tyr Ser Ala Phe Ser Gln Thr Glu Cys Val 
    210                 215                 220                 


Glu Val Gln Gly Glu Ala Ile Pro Leu Val Leu Ala Leu Phe Ala Phe 
225                 230                 235                 240 


Val Gly Phe Met Leu Ile Leu Val Val Val Pro Leu Phe Val Trp Lys 
                245                 250                 255     


Met Gly Arg Leu Leu Gln Tyr Ser Cys Cys Pro Val Val Val Leu Pro 
            260                 265                 270         


Asp Thr Leu Lys Ile Thr Asn Ser Pro Gln Lys Leu Ile Ser Cys Arg 
        275                 280                 285             


Arg Glu Glu Val Asp Ala Cys Ala Thr Ala Val Met Ser Pro Glu Glu 
    290                 295                 300                 


Leu Leu Arg Ala Trp Ile Ser 
305                 310     


<210>  2
<211>  147
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Lys His Leu Leu Met Trp Ser Pro Val Ile Ala Pro Gly Glu Thr 
1               5                   10                  15      


Val Tyr Tyr Ser Val Glu Tyr Gln Gly Glu Tyr Glu Ser Leu Tyr Thr 
            20                  25                  30          


Ser His Ile Trp Ile Pro Ser Ser Trp Cys Ser Leu Thr Glu Gly Pro 
        35                  40                  45              


Glu Cys Asp Val Thr Asp Asp Ile Thr Ala Thr Val Pro Tyr Asn Leu 
    50                  55                  60                  


Arg Val Arg Ala Thr Leu Gly Ser Gln Thr Ser Ala Trp Ser Ile Leu 
65                  70                  75                  80  


Lys His Pro Phe Asn Arg Asn Ser Thr Ile Leu Thr Arg Pro Gly Met 
                85                  90                  95      


Glu Ile Thr Lys Asp Gly Phe His Leu Val Ile Glu Leu Glu Asp Leu 
            100                 105                 110         


Gly Pro Gln Phe Glu Phe Leu Val Ala Tyr Trp Arg Arg Glu Pro Gly 
        115                 120                 125             


Ala Glu Glu Arg Pro Phe Pro Trp Tyr Trp Pro Cys Leu Pro Leu Leu 
    130                 135                 140                 


Ala Ser Cys 
145         


<210>  3
<211>  176
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Lys Ala Ser Ser Leu Ala Phe Ser Leu Leu Ser Ala Ala Phe Tyr 
1               5                   10                  15      


Leu Leu Trp Thr Pro Ser Thr Gly Leu Lys Thr Leu Asn Leu Gly Ser 
            20                  25                  30          


Cys Val Ile Ala Thr Asn Leu Gln Glu Ile Arg Asn Gly Phe Ser Glu 
        35                  40                  45              


Ile Arg Gly Ser Val Gln Ala Lys Asp Gly Asn Ile Asp Ile Arg Ile 
    50                  55                  60                  


Leu Arg Arg Thr Glu Ser Leu Gln Asp Thr Lys Pro Ala Asn Arg Cys 
65                  70                  75                  80  


Cys Leu Leu Arg His Leu Leu Arg Leu Tyr Leu Asp Arg Val Phe Lys 
                85                  90                  95      


Asn Tyr Gln Thr Pro Asp His Tyr Thr Leu Arg Lys Ile Ser Ser Leu 
            100                 105                 110         


Ala Asn Ser Phe Leu Thr Ile Lys Lys Asp Leu Arg Leu Cys His Ala 
        115                 120                 125             


His Met Thr Cys His Cys Gly Glu Glu Ala Met Lys Lys Tyr Ser Gln 
    130                 135                 140                 


Ile Leu Ser His Phe Glu Lys Leu Glu Pro Gln Ala Ala Val Val Lys 
145                 150                 155                 160 


Ala Leu Gly Glu Leu Asp Ile Leu Leu Gln Trp Met Glu Glu Thr Glu 
                165                 170                 175     


<210>  4
<211>  151
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Lys Ala Ser Ser Leu Ala Phe Ser Leu Leu Ser Ala Ala Phe Tyr 
1               5                   10                  15      


Leu Leu Trp Thr Pro Ser Thr Gly Leu Lys Thr Leu Asn Leu Gly Ser 
            20                  25                  30          


Cys Val Ile Ala Thr Asn Leu Gln Glu Ile Arg Asn Gly Phe Ser Glu 
        35                  40                  45              


Ile Arg Gly Ser Val Gln Ala Lys Asp Gly Asn Ile Asp Ile Arg Ile 
    50                  55                  60                  


Leu Arg Arg Thr Glu Ser Leu Gln Asp Thr Lys Pro Ala Asn Arg Cys 
65                  70                  75                  80  


Cys Leu Leu Arg His Leu Leu Arg Leu Tyr Leu Asp Arg Val Phe Lys 
                85                  90                  95      


Asn Tyr Gln Thr Pro Asp His Tyr Thr Leu Arg Lys Ile Ser Ser Leu 
            100                 105                 110         


Ala Asn Ser Phe Leu Thr Ile Lys Lys Asp Leu Arg Leu Cys Leu Glu 
        115                 120                 125             


Pro Gln Ala Ala Val Val Lys Ala Leu Gly Glu Leu Asp Ile Leu Leu 
    130                 135                 140                 


Gln Trp Met Glu Glu Thr Glu 
145                 150     


<210>  5
<211>  177
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Lys Leu Gln Cys Val Ser Leu Trp Leu Leu Gly Thr Ile Leu Ile 
1               5                   10                  15      


Leu Cys Ser Val Asp Asn His Gly Leu Arg Arg Cys Leu Ile Ser Thr 
            20                  25                  30          


Asp Met His His Ile Glu Glu Ser Phe Gln Glu Ile Lys Arg Ala Ile 
        35                  40                  45              


Gln Ala Lys Asp Thr Phe Pro Asn Val Thr Ile Leu Ser Thr Leu Glu 
    50                  55                  60                  


Thr Leu Gln Ile Ile Lys Pro Leu Asp Val Cys Cys Val Thr Lys Asn 
65                  70                  75                  80  


Leu Leu Ala Phe Tyr Val Asp Arg Val Phe Lys Asp His Gln Glu Pro 
                85                  90                  95      


Asn Pro Lys Ile Leu Arg Lys Ile Ser Ser Ile Ala Asn Ser Phe Leu 
            100                 105                 110         


Tyr Met Gln Lys Thr Leu Arg Gln Cys Gln Glu Gln Arg Gln Cys His 
        115                 120                 125             


Cys Arg Gln Glu Ala Thr Asn Ala Thr Arg Val Ile His Asp Asn Tyr 
    130                 135                 140                 


Asp Gln Leu Glu Val His Ala Ala Ala Ile Lys Ser Leu Gly Glu Leu 
145                 150                 155                 160 


Asp Val Phe Leu Ala Trp Ile Asn Lys Asn His Glu Val Met Phe Ser 
                165                 170                 175     


Ala 
    


<210>  6
<211>  215
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Cys Thr Glu Gly Ala Phe Pro His Arg Ser Ala Cys Ser Leu Pro 
1               5                   10                  15      


Leu Thr His Val His Thr His Ile His Val Cys Val Pro Val Leu Trp 
            20                  25                  30          


Gly Ser Val Pro Arg Gly Met Lys Leu Gln Cys Val Ser Leu Trp Leu 
        35                  40                  45              


Leu Gly Thr Ile Leu Ile Leu Cys Ser Val Asp Asn His Gly Leu Arg 
    50                  55                  60                  


Arg Cys Leu Ile Ser Thr Asp Met His His Ile Glu Glu Ser Phe Gln 
65                  70                  75                  80  


Glu Ile Lys Arg Ala Ile Gln Ala Lys Asp Thr Phe Pro Asn Val Thr 
                85                  90                  95      


Ile Leu Ser Thr Leu Glu Thr Leu Gln Ile Ile Lys Pro Leu Asp Val 
            100                 105                 110         


Cys Cys Val Thr Lys Asn Leu Leu Ala Phe Tyr Val Asp Arg Val Phe 
        115                 120                 125             


Lys Asp His Gln Glu Pro Asn Pro Lys Ile Leu Arg Lys Ile Ser Ser 
    130                 135                 140                 


Ile Ala Asn Ser Phe Leu Tyr Met Gln Lys Thr Leu Arg Gln Cys Gln 
145                 150                 155                 160 


Glu Gln Arg Gln Cys His Cys Arg Gln Glu Ala Thr Asn Ala Thr Arg 
                165                 170                 175     


Val Ile His Asp Asn Tyr Asp Gln Leu Glu Val His Ala Ala Ala Ile 
            180                 185                 190         


Lys Ser Leu Gly Glu Leu Asp Val Phe Leu Ala Trp Ile Asn Lys Asn 
        195                 200                 205             


His Glu Val Met Phe Ser Ala 
    210                 215 


<210>  7
<211>  207
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Lys Leu Gln Cys Val Ser Leu Trp Leu Leu Gly Thr Ile Leu Ile 
1               5                   10                  15      


Leu Cys Ser Val Asp Asn His Gly Leu Arg Arg Cys Leu Ile Ser Thr 
            20                  25                  30          


Asp Met His His Ile Glu Glu Ser Phe Gln Glu Ile Lys Arg Ala Ile 
        35                  40                  45              


Gln Ala Lys Asp Thr Phe Pro Asn Val Thr Ile Leu Ser Thr Leu Glu 
    50                  55                  60                  


Thr Leu Gln Ile Ile Lys Pro Leu Asp Val Cys Cys Val Thr Lys Asn 
65                  70                  75                  80  


Leu Leu Ala Phe Tyr Val Asp Arg Val Phe Lys Asp His Gln Glu Pro 
                85                  90                  95      


Asn Pro Lys Ile Leu Arg Lys Ile Ser Ser Ile Ala Asn Ser Phe Leu 
            100                 105                 110         


Tyr Met Gln Lys Thr Leu Arg Gln Cys Val Ser His Trp Val Arg Ile 
        115                 120                 125             


Pro Ala Ser Ala Pro Cys Leu Pro Lys Glu Arg Pro Gly Ser Ala Gly 
    130                 135                 140                 


Pro His Arg Pro Pro Asp Met Val Leu Gly Val Lys Gly Asn Ser Leu 
145                 150                 155                 160 


Arg Thr Ser Thr Gly Arg Thr Val Glu Asn Leu Ser Gln Trp Pro Leu 
                165                 170                 175     


Leu Pro Gln Gly Ser Leu Pro Ala Asp Asn Ser Ser Asp Gly Leu Leu 
            180                 185                 190         


Leu Asp Asn Pro Pro Gly Val Thr Asn Leu Cys Gln His Ile Pro 
        195                 200                 205         


<210>  8
<211>  206
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Asn Phe Gln Gln Arg Leu Gln Ser Leu Trp Thr Leu Ala Arg Pro 
1               5                   10                  15      


Phe Cys Pro Pro Leu Leu Ala Thr Ala Ser Gln Met Gln Met Val Val 
            20                  25                  30          


Leu Pro Cys Leu Gly Phe Thr Leu Leu Leu Trp Ser Gln Val Ser Gly 
        35                  40                  45              


Ala Gln Gly Gln Glu Phe His Phe Gly Pro Cys Gln Val Lys Gly Val 
    50                  55                  60                  


Val Pro Gln Lys Leu Trp Glu Ala Phe Trp Ala Val Lys Asp Thr Met 
65                  70                  75                  80  


Gln Ala Gln Asp Asn Ile Thr Ser Ala Arg Leu Leu Gln Gln Glu Val 
                85                  90                  95      


Leu Gln Asn Val Ser Asp Ala Glu Ser Cys Tyr Leu Val His Thr Leu 
            100                 105                 110         


Leu Glu Phe Tyr Leu Lys Thr Val Phe Lys Asn Tyr His Asn Arg Thr 
        115                 120                 125             


Val Glu Val Arg Thr Leu Lys Ser Phe Ser Thr Leu Ala Asn Asn Phe 
    130                 135                 140                 


Val Leu Ile Val Ser Gln Leu Gln Pro Ser Gln Glu Asn Glu Met Phe 
145                 150                 155                 160 


Ser Ile Arg Asp Ser Ala His Arg Arg Phe Leu Leu Phe Arg Arg Ala 
                165                 170                 175     


Phe Lys Gln Leu Asp Val Glu Ala Ala Leu Thr Lys Ala Leu Gly Glu 
            180                 185                 190         


Val Asp Ile Leu Leu Thr Trp Met Gln Lys Phe Tyr Lys Leu 
        195                 200                 205     


<210>  9
<211>  207
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Asn Phe Gln Gln Arg Leu Gln Ser Leu Trp Thr Leu Ala Ser Arg 
1               5                   10                  15      


Pro Phe Cys Pro Pro Leu Leu Ala Thr Ala Ser Gln Met Gln Met Val 
            20                  25                  30          


Val Leu Pro Cys Leu Gly Phe Thr Leu Leu Leu Trp Ser Gln Val Ser 
        35                  40                  45              


Gly Ala Gln Gly Gln Glu Phe His Phe Gly Pro Cys Gln Val Lys Gly 
    50                  55                  60                  


Val Val Pro Gln Lys Leu Trp Glu Ala Phe Trp Ala Val Lys Asp Thr 
65                  70                  75                  80  


Met Gln Ala Gln Asp Asn Ile Thr Ser Ala Arg Leu Leu Gln Gln Glu 
                85                  90                  95      


Val Leu Gln Asn Val Ser Asp Ala Glu Ser Cys Tyr Leu Val His Thr 
            100                 105                 110         


Leu Leu Glu Phe Tyr Leu Lys Thr Val Phe Lys Asn Tyr His Asn Arg 
        115                 120                 125             


Thr Val Glu Val Arg Thr Leu Lys Ser Phe Ser Thr Leu Ala Asn Asn 
    130                 135                 140                 


Phe Val Leu Ile Val Ser Gln Leu Gln Pro Ser Gln Glu Asn Glu Met 
145                 150                 155                 160 


Phe Ser Ile Arg Asp Ser Ala His Arg Arg Phe Leu Leu Phe Arg Arg 
                165                 170                 175     


Ala Phe Lys Gln Leu Asp Val Glu Ala Ala Leu Thr Lys Ala Leu Gly 
            180                 185                 190         


Glu Val Asp Ile Leu Leu Thr Trp Met Gln Lys Phe Tyr Lys Leu 
        195                 200                 205         


<210>  10
<211>  154
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Asn Phe Gln Gln Arg Leu Gln Ser Leu Trp Thr Leu Ala Ser Arg 
1               5                   10                  15      


Pro Phe Cys Pro Pro Leu Leu Ala Thr Ala Ser Gln Met Gln Met Val 
            20                  25                  30          


Val Leu Pro Cys Leu Gly Phe Thr Leu Leu Leu Trp Ser Gln Val Ser 
        35                  40                  45              


Gly Ala Gln Gly Gln Glu Phe His Phe Gly Pro Cys Gln Val Lys Gly 
    50                  55                  60                  


Val Val Pro Gln Lys Leu Trp Glu Ala Phe Trp Ala Val Lys Asp Thr 
65                  70                  75                  80  


Met Gln Ala Gln Asp Asn Ile Thr Ser Ala Arg Leu Leu Gln Gln Glu 
                85                  90                  95      


Val Leu Gln Asn Val Ser Gln Glu Asn Glu Met Phe Ser Ile Arg Asp 
            100                 105                 110         


Ser Ala His Arg Arg Phe Leu Leu Phe Arg Arg Ala Phe Lys Gln Leu 
        115                 120                 125             


Asp Val Glu Ala Ala Leu Thr Lys Ala Leu Gly Glu Val Asp Ile Leu 
    130                 135                 140                 


Leu Thr Trp Met Gln Lys Phe Tyr Lys Leu 
145                 150                 


<210>  11
<211>  63
<212>  PRT
<213>  Homo sapiens

<400>  11

Met Asn Phe Gln Gln Arg Leu Gln Ser Leu Trp Thr Leu Ala Ser Lys 
1               5                   10                  15      


Leu Arg Ile Thr Ser Arg Val Pro Gly Cys Cys Ser Arg Arg Phe Cys 
            20                  25                  30          


Arg Thr Ser Arg Lys Lys Met Arg Cys Phe Pro Ser Glu Thr Val His 
        35                  40                  45              


Thr Gly Gly Phe Cys Tyr Ser Gly Glu His Ser Asn Ser Trp Thr 
    50                  55                  60              


