                               б

<110>  Ͽ＼޹˾
<120>  ڷΰĺĬںϵ׼ƱӦ
<130>  16A100151WYL
<160>  27  

<170>  PatentIn version 3.3

<210>  1
<211>  250
<212>  PRT
<213> p75NTRİp75NTR-ECD

<400>  1
Met Gly Ala Gly Ala Thr Gly Arg Ala Met Asp Gly Pro Arg Leu Leu 
1                5                  10                  15
Leu Leu Leu Leu Leu Gly Val Ser Leu Gly Gly Ala Lys Glu Ala Cys
            20                  25                  30
Pro Thr Gly Leu Tyr Thr His Ser Gly Glu Cys Cys Lys Ala Cys Asn
        35                  40                  45 
Leu Gly Glu Gly Val Ala Gln Pro Cys Gly Ala Asn Gln Thr Val Cys
    50                  55                  60
Glu Pro Cys Leu Asp Ser Val Thr Phe Ser Asp Val Val Ser Ala Thr
65                  70                  75                  80 
Glu Pro Cys Lys Pro Cys Thr Glu Cys Val Gly Leu Gln Ser Met Ser
                85                  90                  95
Ala Pro Cys Val Glu Ala Asp Asp Ala Val Cys Arg Cys Ala Tyr Gly
            100                 105                 110
Tyr Tyr Gln Asp Glu Thr Thr Gly Arg Cys Glu Ala Cys Arg Val Cys
        115                 120                 125
Glu Ala Gly Ser Gly Leu Val Phe Ser Cys Gln Asp Lys Gln Asn Thr
    130                 135                 140        
Val Cys Glu Glu Cys Pro Asp Gly Thr Tyr Ser Asp Glu Ala Asn His
145                 150                 155                 160 
Val Asp Pro Cys Leu Pro Cys Thr Val Cys Glu Asp Thr Glu Arg Gln
                165                 170                 175
Leu Arg Glu Cys Thr Arg Trp Ala Asp Ala Glu Cys Glu Glu Ile Pro
            180                 185                 190 
Gly Arg Trp Ile Thr Arg Ser Thr Pro Pro Glu Gly Ser Asp Ser Thr
        195                 200                 205 
Ala Pro Ser Thr Gln Glu Pro Glu Ala Pro Pro Glu Gln Asp Leu Ile
    210                 215                 220
Ala Ser Thr Val Ala Gly Val Val Thr Thr Val Met Gly Ser Ser Gln
225                 230                 235                 240 
Pro Val Val Thr Arg Gly Thr Thr Asp Asn
                245                 250

<210>  2
<211>  750
<212>  DNA
<213>  p75NTRİp75NTR-ECD

<400>  2
atgggtgcag gggcgaccgg tagggcgatg gatgggcccc ggctgttact gcttttgcta  60
ttaggcgttt ctcttggcgg ggcgaaggag gcgtgcccga cagggctcta cacgcacagc 120
ggggagtgct gtaaggcatg taacttgggc gaaggcgtgg cacaaccctg tggcgccaac 180
cagactgtat gcgagccctg tctagattct gtgactttct cggatgtagt ctcggctaca 240
gaaccctgca agccttgtac cgaatgcgta gggcttcagt cgatgtcggc tccgtgtgtc 300
gaggctgacg acgcggtgtg tcgctgtgcc tacggctact accaagacga aacaacggga 360
cgctgcgagg cttgtcgcgt atgtgaagct gggagcggcc ttgtgttttc ttgtcaagat 420
aagcaaaaca cagtttgtga agaatgcccc gacgggactt acagcgacga ggcaaatcat 480
gtggaccctt gtcttccgtg taccgtttgc gaggacactg agcgacaact aagggaatgc 540
accaggtggg cagacgccga atgcgaagaa ataccgggca gatggataac acgctccacg 600
ccgcctgagg gtagcgattc cacagctcca tccacacagg agcctgaagc tccaccggaa 660
caggatttaa tcgcttctac cgtggccgga gtggtcacaa cagtcatggg gtcgtcacaa 720
cctgtagtaa cacgagggac gacagacaac                                  750

<210>  3
<211>  269
<212>  PRT
<213> IL-33

<400>  3
Lys Pro Lys Met Lys Tyr Ser Thr Asn Lys Ile Ser Thr Ala Lys Trp
1               5                   10                  15
Lys Asn Thr Ala Ser Lys Ala Leu Cys Phe Lys Leu Gly Lys Ser Gln
            20                  25                  30  
Gln Lys Ala Lys Glu Val Cys Pro Met Tyr Phe Met Lys Leu Arg Ser
        35                  40                  45 
Gly Leu Met Ile Lys Lys Glu Ala Cys Tyr Phe Arg Arg Glu Thr Thr
    50                  55                  60 
Lys Arg Pro Ser Leu Lys Thr Gly Arg Lys His Lys Arg His Leu Val
65                  70                  75                  80 
Leu Ala Ala Cys Gln Gln Gln Ser Thr Val Glu Cys Phe Ala Phe Gly
                85                  90                  95 
Ile Ser Gly Val Gln Lys Tyr Thr Arg Ala Leu His Asp Ser Ser Ile
            100                 105                 110 
Thr Gly Ile Ser Pro Ile Thr Glu Tyr Leu Ala Ser Leu Ser Thr Tyr
        115                 120                 125  
Asn Asp Gln Ser Ile Thr Phe Ala Leu Glu Asp Glu Ser Tyr Glu Ile
    130                 135                 140    
Tyr Val Glu Asp Leu Lys Lys Asp Glu Lys Lys Asp Lys Val Leu Leu
145                 150                 155                 160
Ser Tyr Tyr Glu Ser Gln His Pro Ser Asn Glu Ser Gly Asp Gly Val
                165                 170                 175
Asp Gly Lys Met Leu Met Val Thr Leu Ser Pro Thr Lys Asp Phe Trp
            180                 185                 190 
Leu His Ala Asn Asn Lys Glu His Ser Val Glu Leu His Lys Cys Glu
        195                 200                 205 
Lys Pro Leu Pro Asp Gln Ala Phe Phe Val Leu His Asn Met His Ser
    210                 215                 220 
Asn Cys Val Ser Phe Glu Cys Lys Thr Asp Pro Gly Val Phe Ile Gly
225                 230                 235                 240 
Val Lys Asp Asn His Leu Ala Leu Ile Lys Val Asp Ser Ser Glu Asn
                245                 250                 255 
Leu Cys Thr Glu Asn Ile Leu Phe Lys Leu Ser Glu Thr
            260                 265

<210>  4
<211>  810
<212>  DNA
<213>  IL-33

<400>  4
aaacctaaaa tgaaatattc gactaacaaa attagtaccg cgaaatggaa aaacaccgcg  60
tcaaaggcgc tttgctttaa gcttggcaag tcgcagcaga aagcgaaaga agtctgtcca 120
atgtatttca tgaaactgcg gtcggggtta atgattaaga aagaggcatg ttattttaga 180
cgcgagacca ctaagcgccc ctctctcaag acaggtcgta aacacaaacg tcacctggtg 240
ctagccgctt gtcagcagca atctactgtc gagtgttttg ctttcgggat cagcggggtg 300
caaaagtaca caagggcgct gcatgacagt agcattactg gtataagtcc aataacagag 360
tatcttgctt cactcagtac ttataacgat cagtccataa cgttcgcact ggaggacgaa 420
tcatacgaga tctacgtaga agatctcaag aaagacgaaa aaaaagataa agtcttactg 480
tcgtattatg aatctcagca cccttcgaac gagagcggcg atggagttga cgggaagatg 540
ctaatggtta ctttatcccc taccaaggat ttttggcttc atgccaataa taaagagcac 600
tccgttgagc tccataaatg cgaaaaaccc ctcccggatc aggcgttttt tgttctccac 660
aatatgcata gtaattgcgt ctcattcgag tgtaaaacgg acccaggtgt ttttatcggt 720
gtgaaggata accacctggc tctgattaag gtagactcaa gtgaaaactt gtgcacggaa 780
aacatacttt ttaagttatc ggagacataa                                  810

<210>  5
<211>  15
<212>  PRT
<213>  ˹

<400>  5
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
1               5                   10                  15

<210>  6
<211>  45
<212>  DNA
<213>  ˹

<400>  6
gggggcggtg gtagcggtgg cgggggctca ggcggaggtg ggagc                  45

<210>  7
<211>  534
<212>  PRT
<213>  ˹

<400>  7
Met Gly Ala Gly Ala Thr Gly Arg Ala Met Asp Gly Pro Arg Leu Leu
1                5                  10                  15   
Leu Leu Leu Leu Leu Gly Val Ser Leu Gly Gly Ala Lys Glu Ala Cys
            20                  25                  30 
Pro Thr Gly Leu Tyr Thr His Ser Gly Glu Cys Cys Lys Ala Cys Asn
        35                  40                  45    
Leu Gly Glu Gly Val Ala Gln Pro Cys Gly Ala Asn Gln Thr Val Cys
    50                  55                  60  
Glu Pro Cys Leu Asp Ser Val Thr Phe Ser Asp Val Val Ser Ala Thr
65                  70                  75                  80  
Glu Pro Cys Lys Pro Cys Thr Glu Cys Val Gly Leu Gln Ser Met Ser
                85                  90                  95  
Ala Pro Cys Val Glu Ala Asp Asp Ala Val Cys Arg Cys Ala Tyr Gly
            100                 105                 110  
Tyr Tyr Gln Asp Glu Thr Thr Gly Arg Cys Glu Ala Cys Arg Val Cys
        115                 120                 125 
Glu Ala Gly Ser Gly Leu Val Phe Ser Cys Gln Asp Lys Gln Asn Thr
    130                 135                 140  
Val Cys Glu Glu Cys Pro Asp Gly Thr Tyr Ser Asp Glu Ala Asn His
145                 150                 155                 160 
Val Asp Pro Cys Leu Pro Cys Thr Val Cys Glu Asp Thr Glu Arg Gln
                165                 170                 175  
Leu Arg Glu Cys Thr Arg Trp Ala Asp Ala Glu Cys Glu Glu Ile Pro
            180                 185                 190 
Gly Arg Trp Ile Thr Arg Ser Thr Pro Pro Glu Gly Ser Asp Ser Thr
        195                 200                 205  
Ala Pro Ser Thr Gln Glu Pro Glu Ala Pro Pro Glu Gln Asp Leu Ile
    210                 215                 220 
Ala Ser Thr Val Ala Gly Val Val Thr Thr Val Met Gly Ser Ser Gln
225                 230                 235                 240 
Pro Val Val Thr Arg Gly Thr Thr Asp Asn Gly Gly Gly Gly Ser Gly
                245                 250                 255 
Gly Gly Gly Ser Gly Gly Gly Gly Ser Lys Pro Lys Met Lys Tyr Ser
            260                 265                 270 
Thr Asn Lys Ile Ser Thr Ala Lys Trp Lys Asn Thr Ala Ser Lys Ala
        275                 280                 285 
Leu Cys Phe Lys Leu Gly Lys Ser Gln Gln Lys Ala Lys Glu Val Cys
    290                 295                 300 
Pro Met Tyr Phe Met Lys Leu Arg Ser Gly Leu Met Ile Lys Lys Glu
305                 310                 315                 320 
Ala Cys Tyr Phe Arg Arg Glu Thr Thr Lys Arg Pro Ser Leu Lys Thr
                325                 330                 335  
Gly Arg Lys His Lys Arg His Leu Val Leu Ala Ala Cys Gln Gln Gln
            340                 345                 350 
Ser Thr Val Glu Cys Phe Ala Phe Gly Ile Ser Gly Val Gln Lys Tyr
        355                 360                 365 
Thr Arg Ala Leu His Asp Ser Ser Ile Thr Gly Ile Ser Pro Ile Thr
    370                 375                 380 
Glu Tyr Leu Ala Ser Leu Ser Thr Tyr Asn Asp Gln Ser Ile Thr Phe
385                 390                 395                 400 
Ala Leu Glu Asp Glu Ser Tyr Glu Ile Tyr Val Glu Asp Leu Lys Lys
                405                 410                 415 
Asp Glu Lys Lys Asp Lys Val Leu Leu Ser Tyr Tyr Glu Ser Gln His
            420                 425                 430 
Pro Ser Asn Glu Ser Gly Asp Gly Val Asp Gly Lys Met Leu Met Val
        435                 440                 445 
Thr Leu Ser Pro Thr Lys Asp Phe Trp Leu His Ala Asn Asn Lys Glu
    450                 455                 460 
His Ser Val Glu Leu His Lys Cys Glu Lys Pro Leu Pro Asp Gln Ala
465                 470                 475                 480 
Phe Phe Val Leu His Asn Met His Ser Asn Cys Val Ser Phe Glu Cys
                485                 490                 495 
Lys Thr Asp Pro Gly Val Phe Ile Gly Val Lys Asp Asn His Leu Ala
            500                 505                 510 
Leu Ile Lys Val Asp Ser Ser Glu Asn Leu Cys Thr Glu Asn Ile Leu
        515                 520                 525 
Phe Lys Leu Ser Glu Thr
    530     

<210>  8
<211>  1605
<212>  DNA
<213>  ˹

<400>  8
atgggtgcag gggcgaccgg tagggcgatg gatgggcccc ggctgttact gcttttgcta  60
ttaggcgttt ctcttggcgg ggcgaaggag gcgtgcccga cagggctcta cacgcacagc 120
ggggagtgct gtaaggcatg taacttgggc gaaggcgtgg cacaaccctg tggcgccaac 180
cagactgtat gcgagccctg tctagattct gtgactttct cggatgtagt ctcggctaca 240
gaaccctgca agccttgtac cgaatgcgta gggcttcagt cgatgtcggc tccgtgtgtc 300
gaggctgacg acgcggtgtg tcgctgtgcc tacggctact accaagacga aacaacggga 360
cgctgcgagg cttgtcgcgt atgtgaagct gggagcggcc ttgtgttttc ttgtcaagat 420
aagcaaaaca cagtttgtga agaatgcccc gacgggactt acagcgacga ggcaaatcat 480
gtggaccctt gtcttccgtg taccgtttgc gaggacactg agcgacaact aagggaatgc 540
accaggtggg cagacgccga atgcgaagaa ataccgggca gatggataac acgctccacg 600
ccgcctgagg gtagcgattc cacagctcca tccacacagg agcctgaagc tccaccggaa 660
caggatttaa tcgcttctac cgtggccgga gtggtcacaa cagtcatggg gtcgtcacaa 720
cctgtagtaa cacgagggac gacagacaac gggggcggtg gtagcggtgg cgggggctca 780
ggcggaggtg ggagcaaacc taaaatgaaa tattcgacta acaaaattag taccgcgaaa 840
tggaaaaaca ccgcgtcaaa ggcgctttgc tttaagcttg gcaagtcgca gcagaaagcg 900
aaagaagtct gtccaatgta tttcatgaaa ctgcggtcgg ggttaatgat taagaaagag 960
gcatgttatt ttagacgcga gaccactaag cgcccctctc tcaagacagg tcgtaaacac1020
aaacgtcacc tggtgctagc cgcttgtcag cagcaatcta ctgtcgagtg ttttgctttc1080
gggatcagcg gggtgcaaaa gtacacaagg gcgctgcatg acagtagcat tactggtata1140
agtccaataa cagagtatct tgcttcactc agtacttata acgatcagtc cataacgttc1200
gcactggagg acgaatcata cgagatctac gtagaagatc tcaagaaaga cgaaaaaaaa1260
gataaagtct tactgtcgta ttatgaatct cagcaccctt cgaacgagag cggcgatgga1320
gttgacggga agatgctaat ggttacttta tcccctacca aggatttttg gcttcatgcc1380
aataataaag agcactccgt tgagctccat aaatgcgaaa aacccctccc ggatcaggcg1440
ttttttgttc tccacaatat gcatagtaat tgcgtctcat tcgagtgtaa aacggaccca1500
ggtgttttta tcggtgtgaa ggataaccac ctggctctga ttaaggtaga ctcaagtgaa1560
aacttgtgca cggaaaacat actttttaag ttatcggaga cataa                1605

<210>  9
<211>  18
<212>  DNA
<213>  ˹	

<400>  9
atgggtgcag gggcgacc   18

<210>  10
<211>  29
<212>  DNA
<213>  ˹

<400>  10
gttgtctgtc gtccctcgtg ttactacag  29

<210>  11
<211>  42
<212>  DNA
<213>  ˹

<400>  11
aaacctaaaa tgaaatattc gactaacaaa attagtaccg cg    42

<210>  12
<211>  35
<212>  DNA
<213>  ˹

<400>  12
ttatgtctcg gatagcttga agagaatgtt ttcgg   35

<210>  13
<211>  27
<212>  DNA
<213>  ˹

<400>  13
cgcggtacca tgggtgcagg ggcgacc  27

<210>  14
<211>  65
<212>  DNA
<213>  ˹

<400>  14
gctcccacct ccgcctgagc ccccgccacc gctaccaccg cccccgttgt ctgtcgtccc  60
tcgtg                                                              65

<210>  15
<211>  62
<212>  DNA
<213>  ˹

<400>  15
cgcggtacta attttgttag tcgaatattt cattttaggt ttgctcaggc ggaggtggga  60
gc                                                                 62


<210>  16
<211>  62
<212>  DNA
<213>  ˹

<400>  16
gctcccacct ccgcctgagc aaacctaaaa tgaaatattc gactaacaaa attagtaccg  60
cg                                                                 62

<210>  17
<211>  44
<212>  DNA
<213>  ˹

<400>  17
acgtctagat tatgtctcgg atagcttgaa gagaatgttt tcgg  44

<210>  18
<211>  8
<212>  PRT
<213>  ˹

<400>  18
Asp Tyr Lys Asp Asp Asp Asp Lys 
1                5

<210>  19
<211>  24
<212>  DNA
<213>  ˹

<400>  19
gattacaaag atgacgatga taaa   24

<210>  20
<211>  22
<212>  PRT
<213>  ˹

<400>  20
Asp Tyr Lys Asp His Asp Gly Asp Tyr Lys Asp His Asp Ile Asp Tyr 
1                5                  10                  15
Lys Asp Asp Asp Asp Lys
            20

<210>  21
<211>  65
<212>  DNA
<213>  ˹

<400>  21
gactacaaag accatgacgg tgattataaa gatcatgaca tcgactacaa ggatgacgat  60
gacaag                                                             65

<210>  22
<211>  45
<212>  DNA
<213>  ˹

<400>  22
atggattaca aagatgacga tgataaaggt gcaggggcga ccggt                  45

<210>  23
<211>  44
<212>  DNA
<213>  ˹

<400>  23
cgcggtacca tggattacaa agatgacgat gataaaggtg cagg                    44

<210>  24
<211>  54
<212>  DNA
<213>  ˹

<400>  24
cgcggtacca tggattacaa agatgacgat gataaaggtg caggggcgac cggt        54

<210>  25
<211>  41
<212>  DNA
<213>  ˹

<400>  25
acgtctagat tagttgtctg tcgtccctcg tgttactaca g                      41

<210>  26
<211>  78
<212>  DNA
<213>  ˹

<400>  26
cgcggtacca tggattacaa agatgacgat gataaaaaac ctaaaatgaa atattcgact 60 aacaaaatta gtaccgcg                                               78

<210>  27
<211>  44
<212>  DNA
<213>  ˹

<400>  27
acgtctagat tatgtctcgg atagcttgaa gagaatgttt tcgg                   44  
