                         SEQUENCE LISTING

<110>  Sackstein, Robert
 
<120>  GLYCOENGINEERING OF E-SELECTIN LIGANDS

<130>  C077747/0546300pct

<150>  US 62/339,704
<151>  2016-05-20

<150>  US 62/354,350
<151>  2016-06-24

<160>  10    

<170>  PatentIn version 3.5

<210>  1
<211>  2043
<212>  DNA
<213>  Homo sapiens

<400>  1
aggaaacctg ccatggcctc ctggtgagct gtcctcatcc actgctcgct gcctctccag       60

atactctgac ccatggatcc cctgggtgca gccaagccac aatggccatg gcgccgctgt      120

ctggccgcac tgctatttca gctgctggtg gctgtgtgtt tcttctccta cctgcgtgtg      180

tcccgagacg atgccactgg atcccctagg gctcccagtg ggtcctcccg acaggacacc      240

actcccaccc gccccaccct cctgatcctg ctatggacat ggcctttcca catccctgtg      300

gctctgtccc gctgttcaga gatggtgccc ggcacagccg actgccacat cactgccgac      360

cgcaaggtgt acccacaggc agacacggtc atcgtgcacc actgggatat catgtccaac      420

cctaagtcac gcctcccacc ttccccgagg ccgcaggggc agcgctggat ctggttcaac      480

ttggagccac cccctaactg ccagcacctg gaagccctgg acagatactt caatctcacc      540

atgtcctacc gcagcgactc cgacatcttc acgccctacg gctggctgga gccgtggtcc      600

ggccagcctg cccacccacc gctcaacctc tcggccaaga ccgagctggt ggcctgggcg      660

gtgtccaact ggaagccgga ctcagccagg gtgcgctact accagagcct gcaggctcat      720

ctcaaggtgg acgtgtacgg acgctcccac aagcccctgc ccaaggggac catgatggag      780

acgctgtccc ggtacaagtt ctacctggcc ttcgagaact ccttgcaccc cgactacatc      840

accgagaagc tgtggaggaa cgccctggag gcctgggccg tgcccgtggt gctgggcccc      900

agcagaagca actacgagag gttcctgcca cccgacgcct tcatccacgt ggacgacttc      960

cagagcccca aggacctggc ccggtacctg caggagctgg acaaggacca cgcccgctac     1020

ctgagctact ttcgctggcg ggagacgctg cggcctcgct ccttcagctg ggcactggat     1080

ttctgcaagg cctgctggaa actgcagcag gaatccaggt accagacggt gcgcagcata     1140

gcggcttggt tcacctgaga ggccggcatg gtgcctgggc tgccgggaac ctcatctgcc     1200

tggggcctca cctgctggag tcctttgtgg ccaaccctct ctcttacctg ggacctcaca     1260

cgctgggctt cacggctgcc aggagcctct cccctccaga agacttgcct gctagggacc     1320

tcgcctgctg gggacctcgc ctgttgggga cctcacctgc tggggacctc acctgctggg     1380

gaccttggct gctggaggct gcacctactg aggatgtcgg cggtcgggga ctttacctgc     1440

tgggacctgc tcccagagac cttgccacac tgaatctcac ctgctgggga cctcaccctg     1500

gagggccctg ggccctgggg aactggctta cttggggccc cacccgggag tgatggttct     1560

ggctgatttg tttgtgatgt tgttagccgc ctgtgagggg tgcagagaga tcatcacggc     1620

acggtttcca gatgtaatac tgcaaggaaa aatgatgacg tgtctcctca ctctagaggg     1680

gttggtccca tgggttaaga gctcacccca ggttctcacc tcaggggtta agagctcaga     1740

gttcagacag gtccaagttc aagcccagga ccaccactta tagggtacag gtgggatcga     1800

ctgtaaatga ggacttctgg aacattccaa atattctggg gttgagggaa attgctgctg     1860

tctacaaaat gccaagggtg gacaggcgct gtggctcacg cctgtaattc cagcactttg     1920

ggaggctgag gtaggaggat tgattgaggc caagagttaa agaccagcct ggtcaatata     1980

gcaagaccac gtctctaaat aaaaaataat aggccggcca ggaaaaaaaa aaaaaaaaaa     2040

aaa                                                                   2043


<210>  2
<211>  361
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Asp Pro Leu Gly Ala Ala Lys Pro Gln Trp Pro Trp Arg Arg Cys 
1               5                   10                  15      


Leu Ala Ala Leu Leu Phe Gln Leu Leu Val Ala Val Cys Phe Phe Ser 
            20                  25                  30          


Tyr Leu Arg Val Ser Arg Asp Asp Ala Thr Gly Ser Pro Arg Ala Pro 
        35                  40                  45              


Ser Gly Ser Ser Arg Gln Asp Thr Thr Pro Thr Arg Pro Thr Leu Leu 
    50                  55                  60                  


Ile Leu Leu Trp Thr Trp Pro Phe His Ile Pro Val Ala Leu Ser Arg 
65                  70                  75                  80  


Cys Ser Glu Met Val Pro Gly Thr Ala Asp Cys His Ile Thr Ala Asp 
                85                  90                  95      


Arg Lys Val Tyr Pro Gln Ala Asp Thr Val Ile Val His His Trp Asp 
            100                 105                 110         


Ile Met Ser Asn Pro Lys Ser Arg Leu Pro Pro Ser Pro Arg Pro Gln 
        115                 120                 125             


Gly Gln Arg Trp Ile Trp Phe Asn Leu Glu Pro Pro Pro Asn Cys Gln 
    130                 135                 140                 


His Leu Glu Ala Leu Asp Arg Tyr Phe Asn Leu Thr Met Ser Tyr Arg 
145                 150                 155                 160 


Ser Asp Ser Asp Ile Phe Thr Pro Tyr Gly Trp Leu Glu Pro Trp Ser 
                165                 170                 175     


Gly Gln Pro Ala His Pro Pro Leu Asn Leu Ser Ala Lys Thr Glu Leu 
            180                 185                 190         


Val Ala Trp Ala Val Ser Asn Trp Lys Pro Asp Ser Ala Arg Val Arg 
        195                 200                 205             


Tyr Tyr Gln Ser Leu Gln Ala His Leu Lys Val Asp Val Tyr Gly Arg 
    210                 215                 220                 


Ser His Lys Pro Leu Pro Lys Gly Thr Met Met Glu Thr Leu Ser Arg 
225                 230                 235                 240 


Tyr Lys Phe Tyr Leu Ala Phe Glu Asn Ser Leu His Pro Asp Tyr Ile 
                245                 250                 255     


Thr Glu Lys Leu Trp Arg Asn Ala Leu Glu Ala Trp Ala Val Pro Val 
            260                 265                 270         


Val Leu Gly Pro Ser Arg Ser Asn Tyr Glu Arg Phe Leu Pro Pro Asp 
        275                 280                 285             


Ala Phe Ile His Val Asp Asp Phe Gln Ser Pro Lys Asp Leu Ala Arg 
    290                 295                 300                 


Tyr Leu Gln Glu Leu Asp Lys Asp His Ala Arg Tyr Leu Ser Tyr Phe 
305                 310                 315                 320 


Arg Trp Arg Glu Thr Leu Arg Pro Arg Ser Phe Ser Trp Ala Leu Asp 
                325                 330                 335     


Phe Cys Lys Ala Cys Trp Lys Leu Gln Gln Glu Ser Arg Tyr Gln Thr 
            340                 345                 350         


Val Arg Ser Ile Ala Ala Trp Phe Thr 
        355                 360     


<210>  3
<211>  2159
<212>  DNA
<213>  Homo sapiens

<400>  3
cgctcctcca cgcctgcgga cgcgtggcga gcggaggcag cgctgcctgt tcgcgccatg       60

ggggcaccgt ggggctcgcc gacggcggcg gcgggcgggc ggcgcgggtg gcgccgaggc      120

cgggggctgc catggaccgt ctgtgtgctg gcggccgccg gcttgacgtg tacggcgctg      180

atcacctacg cttgctgggg gcagctgccg ccgctgccct gggcgtcgcc aaccccgtcg      240

cgaccggtgg gcgtgctgct gtggtgggag cccttcgggg ggcgcgatag cgccccgagg      300

ccgccccctg actgccggct gcgcttcaac atcagcggct gccgcctgct caccgaccgc      360

gcgtcctacg gagaggctca ggccgtgctt ttccaccacc gcgacctcgt gaaggggccc      420

cccgactggc ccccgccctg gggcatccag gcgcacactg ccgaggaggt ggatctgcgc      480

gtgttggact acgaggaggc agcggcggcg gcagaagccc tggcgacctc cagccccagg      540

cccccgggcc agcgctgggt ttggatgaac ttcgagtcgc cctcgcactc cccggggctg      600

cgaagcctgg caagtaacct cttcaactgg acgctctcct accgggcgga ctcggacgtc      660

tttgtgcctt atggctacct ctaccccaga agccaccccg gcgacccgcc ctcaggcctg      720

gccccgccac tgtccaggaa acaggggctg gtggcatggg tggtgagcca ctgggacgag      780

cgccaggccc gggtccgcta ctaccaccaa ctgagccaac atgtgaccgt ggacgtgttc      840

ggccggggcg ggccggggca gccggtgccc gaaattgggc tcctgcacac agtggcccgc      900

tacaagttct acctggcttt cgagaactcg cagcacctgg attatatcac cgagaagctc      960

tggcgcaacg cgttgctcgc tggggcggtg ccggtggtgc tgggcccaga ccgtgccaac     1020

tacgagcgct ttgtgccccg cggcgccttc atccacgtgg acgacttccc aagtgcctcc     1080

tccctggcct cgtacctgct tttcctcgac cgcaaccccg cggtctatcg ccgctacttc     1140

cactggcgcc ggagctacgc tgtccacatc acctccttct gggacgagcc ttggtgccgg     1200

gtgtgccagg ctgtacagag ggctggggac cggcccaaga gcatacggaa cttggccagc     1260

tggttcgagc ggtgaagccg cgctcccctg gaagcgaccc aggggaggcc aagttgtcag     1320

ctttttgatc ctctactgtg catctccttg actgccgcat catgggagta agttcttcaa     1380

acacccattt ttgctctatg ggaaaaaaac gatttaccaa ttaatattac tcagcacaga     1440

gatgggggcc cggtttccat attttttgca cagctagcaa ttgggctccc tttgctgctg     1500

atgggcatca ttgtttaggg gtgaaggagg gggttcttcc tcaccttgta accagtgcag     1560

aaatgaaata gcttagcggc aagaagccgt tgaggcggtt tcctgaattt ccccatctgc     1620

cacaggccat atttgtggcc cgtgcagctt ccaaatctca tacacaactg ttcccgattc     1680

acgtttttct ggaccaaggt gaagcaaatt tgtggttgta gaaggagcct tgttggtgga     1740

gagtggaagg actgtggctg caggtgggac tttgttgttt ggattcctca cagccttggc     1800

tcctgagaaa ggtgaggagg gcagtccaag aggggccgct gacttctttc acaagtacta     1860

tctgttcccc tgtcctgtga atggaagcaa agtgctggat tgtccttgga ggaaacttaa     1920

gatgaataca tgcgtgtacc tcactttaca taagaaatgt attcctgaaa agctgcattt     1980

aaatcaagtc ccaaattcat tgacttaggg gagttcagta tttaatgaaa ccctatggag     2040

aatttatccc tttacaatgt gaatagtcat ctcctaattt gtttcttctg tctttatgtt     2100

tttctataac ctggattttt taaatcatat taaaattaca gatgtgaaaa taaaaaaaa      2159


<210>  4
<211>  530
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Arg Arg Leu Trp Gly Ala Ala Arg Lys Pro Ser Gly Ala Gly Trp 
1               5                   10                  15      


Glu Lys Glu Trp Ala Glu Ala Pro Gln Glu Ala Pro Gly Ala Trp Ser 
            20                  25                  30          


Gly Arg Leu Gly Pro Gly Arg Ser Gly Arg Lys Gly Arg Ala Val Pro 
        35                  40                  45              


Gly Trp Ala Ser Trp Pro Ala His Leu Ala Leu Ala Ala Arg Pro Ala 
    50                  55                  60                  


Arg His Leu Gly Gly Ala Gly Gln Gly Pro Arg Pro Leu His Ser Gly 
65                  70                  75                  80  


Thr Ala Pro Phe His Ser Arg Ala Ser Gly Glu Arg Gln Arg Arg Leu 
                85                  90                  95      


Glu Pro Gln Leu Gln His Glu Ser Arg Cys Arg Ser Ser Thr Pro Ala 
            100                 105                 110         


Asp Ala Trp Arg Ala Glu Ala Ala Leu Pro Val Arg Ala Met Gly Ala 
        115                 120                 125             


Pro Trp Gly Ser Pro Thr Ala Ala Ala Gly Gly Arg Arg Gly Trp Arg 
    130                 135                 140                 


Arg Gly Arg Gly Leu Pro Trp Thr Val Cys Val Leu Ala Ala Ala Gly 
145                 150                 155                 160 


Leu Thr Cys Thr Ala Leu Ile Thr Tyr Ala Cys Trp Gly Gln Leu Pro 
                165                 170                 175     


Pro Leu Pro Trp Ala Ser Pro Thr Pro Ser Arg Pro Val Gly Val Leu 
            180                 185                 190         


Leu Trp Trp Glu Pro Phe Gly Gly Arg Asp Ser Ala Pro Arg Pro Pro 
        195                 200                 205             


Pro Asp Cys Arg Leu Arg Phe Asn Ile Ser Gly Cys Arg Leu Leu Thr 
    210                 215                 220                 


Asp Arg Ala Ser Tyr Gly Glu Ala Gln Ala Val Leu Phe His His Arg 
225                 230                 235                 240 


Asp Leu Val Lys Gly Pro Pro Asp Trp Pro Pro Pro Trp Gly Ile Gln 
                245                 250                 255     


Ala His Thr Ala Glu Glu Val Asp Leu Arg Val Leu Asp Tyr Glu Glu 
            260                 265                 270         


Ala Ala Ala Ala Ala Glu Ala Leu Ala Thr Ser Ser Pro Arg Pro Pro 
        275                 280                 285             


Gly Gln Arg Trp Val Trp Met Asn Phe Glu Ser Pro Ser His Ser Pro 
    290                 295                 300                 


Gly Leu Arg Ser Leu Ala Ser Asn Leu Phe Asn Trp Thr Leu Ser Tyr 
305                 310                 315                 320 


Arg Ala Asp Ser Asp Val Phe Val Pro Tyr Gly Tyr Leu Tyr Pro Arg 
                325                 330                 335     


Ser His Pro Gly Asp Pro Pro Ser Gly Leu Ala Pro Pro Leu Ser Arg 
            340                 345                 350         


Lys Gln Gly Leu Val Ala Trp Val Val Ser His Trp Asp Glu Arg Gln 
        355                 360                 365             


Ala Arg Val Arg Tyr Tyr His Gln Leu Ser Gln His Val Thr Val Asp 
    370                 375                 380                 


Val Phe Gly Arg Gly Gly Pro Gly Gln Pro Val Pro Glu Ile Gly Leu 
385                 390                 395                 400 


Leu His Thr Val Ala Arg Tyr Lys Phe Tyr Leu Ala Phe Glu Asn Ser 
                405                 410                 415     


Gln His Leu Asp Tyr Ile Thr Glu Lys Leu Trp Arg Asn Ala Leu Leu 
            420                 425                 430         


Ala Gly Ala Val Pro Val Val Leu Gly Pro Asp Arg Ala Asn Tyr Glu 
        435                 440                 445             


Arg Phe Val Pro Arg Gly Ala Phe Ile His Val Asp Asp Phe Pro Ser 
    450                 455                 460                 


Ala Ser Ser Leu Ala Ser Tyr Leu Leu Phe Leu Asp Arg Asn Pro Ala 
465                 470                 475                 480 


Val Tyr Arg Arg Tyr Phe His Trp Arg Arg Ser Tyr Ala Val His Ile 
                485                 490                 495     


Thr Ser Phe Trp Asp Glu Pro Trp Cys Arg Val Cys Gln Ala Val Gln 
            500                 505                 510         


Arg Ala Gly Asp Arg Pro Lys Ser Ile Arg Asn Leu Ala Ser Trp Phe 
        515                 520                 525             


Glu Arg 
    530 


<210>  5
<211>  1310
<212>  DNA
<213>  Homo sapiens

<400>  5
tttatgacaa gctgtgtcat aaattataac agcttctctc aggacactgt ggccaggaag       60

tgggtgatct tccttaatga ccctcactcc tctctcctct cttcccagct actctgaccc      120

atggatcccc tgggcccagc caagccacag tggctgtggc gccgctgtct ggccgggctg      180

ctgtttcagc tgctggtggc tgtgtgtttc ttctcctacc tgcgtgtgtc ccgagacgat      240

gccactggat cccctaggcc agggcttatg gcagtggaac ctgtcaccgg ggctcccaat      300

gggtcccgct gccaggacag catggcgacc cctgcccacc ccaccctact gatcctgctg      360

tggacgtggc cttttaacac acccgtggct ctgccccgct gctcagagat ggtgcccggc      420

gcggccgact gcaacatcac tgccgactcc agtgtgtacc cacaggcaga cgcggtcatc      480

gtgcaccact gggatatcat gtacaacccc agtgccaacc tcccgccccc caccaggccg      540

caggggcagc gctggatctg gttcagcatg gagtccccca gcaactgccg gcacctggaa      600

gccctggacg gatacttcaa tctcaccatg tcctaccgca gcgactccga catcttcacg      660

ccctacggct ggctggagcc gtggtccggc cagcctgccc acccaccgct caacctctcg      720

gccaagaccg agctggtggc ctgggcggtg tccaactgga agccggactc ggccagggtg      780

cgctactacc agagcctgca ggctcatctc aaggtggacg tgtacggacg ctcccacaag      840

cccctgccca aggggaccat gatggagacg ctgtcccggt acaagttcta tctggccttc      900

gagaactcct tgcaccccga ctacatcacc gagaagctgt ggaggaacgc cctggaggcc      960

tgggccgtgc ccgtggtgct gggccccagc agaagcaact acgagaggtt cctgccgccc     1020

gacgccttca tccacgtgga tgacttccag agccccaagg acctggcccg gtacctgcag     1080

gagctggaca aggaccacgc ccgctacctg agctactttc gctggcggga gacgctgcgg     1140

cctcgctcct tcagctgggc actggctttc tgcaaggcct gctggaagct gcagcaggaa     1200

tccaggtacc agacggtgcg cagcatagcg gcttggttca cctgagaggc cggcatgggg     1260

cctgggctgc cagggacctc actttcccag ggcctcacct acctagggtc                1310


<210>  6
<211>  374
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Asp Pro Leu Gly Pro Ala Lys Pro Gln Trp Leu Trp Arg Arg Cys 
1               5                   10                  15      


Leu Ala Gly Leu Leu Phe Gln Leu Leu Val Ala Val Cys Phe Phe Ser 
            20                  25                  30          


Tyr Leu Arg Val Ser Arg Asp Asp Ala Thr Gly Ser Pro Arg Pro Gly 
        35                  40                  45              


Leu Met Ala Val Glu Pro Val Thr Gly Ala Pro Asn Gly Ser Arg Cys 
    50                  55                  60                  


Gln Asp Ser Met Ala Thr Pro Ala His Pro Thr Leu Leu Ile Leu Leu 
65                  70                  75                  80  


Trp Thr Trp Pro Phe Asn Thr Pro Val Ala Leu Pro Arg Cys Ser Glu 
                85                  90                  95      


Met Val Pro Gly Ala Ala Asp Cys Asn Ile Thr Ala Asp Ser Ser Val 
            100                 105                 110         


Tyr Pro Gln Ala Asp Ala Val Ile Val His His Trp Asp Ile Met Tyr 
        115                 120                 125             


Asn Pro Ser Ala Asn Leu Pro Pro Pro Thr Arg Pro Gln Gly Gln Arg 
    130                 135                 140                 


Trp Ile Trp Phe Ser Met Glu Ser Pro Ser Asn Cys Arg His Leu Glu 
145                 150                 155                 160 


Ala Leu Asp Gly Tyr Phe Asn Leu Thr Met Ser Tyr Arg Ser Asp Ser 
                165                 170                 175     


Asp Ile Phe Thr Pro Tyr Gly Trp Leu Glu Pro Trp Ser Gly Gln Pro 
            180                 185                 190         


Ala His Pro Pro Leu Asn Leu Ser Ala Lys Thr Glu Leu Val Ala Trp 
        195                 200                 205             


Ala Val Ser Asn Trp Lys Pro Asp Ser Ala Arg Val Arg Tyr Tyr Gln 
    210                 215                 220                 


Ser Leu Gln Ala His Leu Lys Val Asp Val Tyr Gly Arg Ser His Lys 
225                 230                 235                 240 


Pro Leu Pro Lys Gly Thr Met Met Glu Thr Leu Ser Arg Tyr Lys Phe 
                245                 250                 255     


Tyr Leu Ala Phe Glu Asn Ser Leu His Pro Asp Tyr Ile Thr Glu Lys 
            260                 265                 270         


Leu Trp Arg Asn Ala Leu Glu Ala Trp Ala Val Pro Val Val Leu Gly 
        275                 280                 285             


Pro Ser Arg Ser Asn Tyr Glu Arg Phe Leu Pro Pro Asp Ala Phe Ile 
    290                 295                 300                 


His Val Asp Asp Phe Gln Ser Pro Lys Asp Leu Ala Arg Tyr Leu Gln 
305                 310                 315                 320 


Glu Leu Asp Lys Asp His Ala Arg Tyr Leu Ser Tyr Phe Arg Trp Arg 
                325                 330                 335     


Glu Thr Leu Arg Pro Arg Ser Phe Ser Trp Ala Leu Ala Phe Cys Lys 
            340                 345                 350         


Ala Cys Trp Lys Leu Gln Gln Glu Ser Arg Tyr Gln Thr Val Arg Ser 
        355                 360                 365             


Ile Ala Ala Trp Phe Thr 
    370                 


<210>  7
<211>  1126
<212>  DNA
<213>  Homo sapiens

<400>  7
cagatactct gacccatgga tcccctgggc ccggccaagc cacagtggtc gtggcgctgc       60

tgtctgacca cgctgctgtt tcagctgctg atggctgtgt gtttcttctc ctatctgcgt      120

gtgtctcaag acgatcccac tgtgtaccct aatgggtccc gcttcccaga cagcacaggg      180

acccccgccc actccatccc cctgatcctg ctgtggacgt ggccttttaa caaacccata      240

gctctgcccc gctgctcaga gatggtgcct ggcacggctg actgcaacat cactgccgac      300

cgcaaggtgt atccacaggc agacgcggtc atcgtgcacc accgagaggt catgtacaac      360

cccagtgccc agctcccacg ctccccgagg cggcaggggc agcgatggat ctggttcagc      420

atggagtccc caagccactg ctggcagctg aaagccatgg acggatactt caatctcacc      480

atgtcctacc gcagcgactc cgacatcttc acgccctacg gctggctgga gccgtggtcc      540

ggccagcctg cccacccacc gctcaacctc tcggccaaga ccgagctggt ggcctgggca      600

gtgtccaact gggggccaaa ctccgccagg gtgcgctact accagagcct gcaggcccat      660

ctcaaggtgg acgtgtacgg acgctcccac aagcccctgc cccagggaac catgatggag      720

acgctgtccc ggtacaagtt ctatctggcc ttcgagaact ccttgcaccc cgactacatc      780

accgagaagc tgtggaggaa cgccctggag gcctgggccg tgcccgtggt gctgggcccc      840

agcagaagca actacgagag gttcctgccg cccgacgcct tcatccacgt ggacgacttc      900

cagagcccca aggacctggc ccggtacctg caggagctgg acaaggacca cgcccgctac      960

ctgagctact ttcgctggcg ggagacgctg cggcctcgct ccttcagctg ggcactcgct     1020

ttctgcaagg cctgctggaa actgcaggag gaatccaggt accagacacg cggcatagcg     1080

gcttggttca cctgagaggc ccggcatggg gcctgggctg ccaggg                    1126


<210>  8
<211>  359
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Asp Pro Leu Gly Pro Ala Lys Pro Gln Trp Ser Trp Arg Cys Cys 
1               5                   10                  15      


Leu Thr Thr Leu Leu Phe Gln Leu Leu Met Ala Val Cys Phe Phe Ser 
            20                  25                  30          


Tyr Leu Arg Val Ser Gln Asp Asp Pro Thr Val Tyr Pro Asn Gly Ser 
        35                  40                  45              


Arg Phe Pro Asp Ser Thr Gly Thr Pro Ala His Ser Ile Pro Leu Ile 
    50                  55                  60                  


Leu Leu Trp Thr Trp Pro Phe Asn Lys Pro Ile Ala Leu Pro Arg Cys 
65                  70                  75                  80  


Ser Glu Met Val Pro Gly Thr Ala Asp Cys Asn Ile Thr Ala Asp Arg 
                85                  90                  95      


Lys Val Tyr Pro Gln Ala Asp Ala Val Ile Val His His Arg Glu Val 
            100                 105                 110         


Met Tyr Asn Pro Ser Ala Gln Leu Pro Arg Ser Pro Arg Arg Gln Gly 
        115                 120                 125             


Gln Arg Trp Ile Trp Phe Ser Met Glu Ser Pro Ser His Cys Trp Gln 
    130                 135                 140                 


Leu Lys Ala Met Asp Gly Tyr Phe Asn Leu Thr Met Ser Tyr Arg Ser 
145                 150                 155                 160 


Asp Ser Asp Ile Phe Thr Pro Tyr Gly Trp Leu Glu Pro Trp Ser Gly 
                165                 170                 175     


Gln Pro Ala His Pro Pro Leu Asn Leu Ser Ala Lys Thr Glu Leu Val 
            180                 185                 190         


Ala Trp Ala Val Ser Asn Trp Gly Pro Asn Ser Ala Arg Val Arg Tyr 
        195                 200                 205             


Tyr Gln Ser Leu Gln Ala His Leu Lys Val Asp Val Tyr Gly Arg Ser 
    210                 215                 220                 


His Lys Pro Leu Pro Gln Gly Thr Met Met Glu Thr Leu Ser Arg Tyr 
225                 230                 235                 240 


Lys Phe Tyr Leu Ala Phe Glu Asn Ser Leu His Pro Asp Tyr Ile Thr 
                245                 250                 255     


Glu Lys Leu Trp Arg Asn Ala Leu Glu Ala Trp Ala Val Pro Val Val 
            260                 265                 270         


Leu Gly Pro Ser Arg Ser Asn Tyr Glu Arg Phe Leu Pro Pro Asp Ala 
        275                 280                 285             


Phe Ile His Val Asp Asp Phe Gln Ser Pro Lys Asp Leu Ala Arg Tyr 
    290                 295                 300                 


Leu Gln Glu Leu Asp Lys Asp His Ala Arg Tyr Leu Ser Tyr Phe Arg 
305                 310                 315                 320 


Trp Arg Glu Thr Leu Arg Pro Arg Ser Phe Ser Trp Ala Leu Ala Phe 
                325                 330                 335     


Cys Lys Ala Cys Trp Lys Leu Gln Glu Glu Ser Arg Tyr Gln Thr Arg 
            340                 345                 350         


Gly Ile Ala Ala Trp Phe Thr 
        355                 


<210>  9
<211>  1701
<212>  DNA
<213>  Homo sapiens

<400>  9
aaggagcaca gttccaggcg gggctgagct agggcgtagc tgtgatttca ggggcacctc       60

tggcggctgc cgtgatttga gaatctcggg tctcttggct gactgatcct gggagactgt      120

ggatgaataa tgctgggcac ggccccaccc ggaggctgcg aggcttgggg gtcctggccg      180

gggtggctct gctcgctgcc ctctggctcc tgtggctgct ggggtcagcc cctcggggta      240

ccccggcacc ccagcccacg atcaccatcc ttgtctggca ctggcccttc actgaccagc      300

ccccagagct gcccagcgac acctgcaccc gctacggcat cgcccgctgc cacctgagtg      360

ccaaccgaag cctgctggcc agcgccgacg ccgtggtctt ccaccaccgc gagctgcaga      420

cccggcggtc ccacctgccc ctggcccagc ggccgcgagg gcagccctgg gtgtgggcct      480

ccatggagtc tcctagccac acccacggcc tcagccacct ccgaggcatc ttcaactggg      540

tgctgagcta ccggcgcgac tcggacatct ttgtgcccta tggccgcctg gagccccact      600

gggggccctc gccaccgctg ccagccaaga gcagggtggc cgcctgggtg gtcagcaact      660

tccaggagcg gcagctgcgt gccaggctgt accggcagct ggcgcctcat ctgcgggtgg      720

atgtctttgg ccgtgccaat ggacggccac tgtgcgccag ctgcctggtg cccaccgtgg      780

cccagtaccg cttctacctg tcctttgaga actctcagca ccgcgactac attacggaga      840

aattctggcg caacgcactg gtggctggca ctgtgccagt ggtgctgggg cccccacggg      900

ccacctatga ggccttcgtg ccggctgacg ccttcgtgca tgtggatgac tttggctcag      960

cccgagagct ggcggctttc ctcactggca tgaatgagag ccgataccaa cgcttctttg     1020

cctggcgtga caggctccgc gtgcgactgt tcaccgactg gcgggaacgt ttctgtgcca     1080

tctgtgaccg ctacccacac ctaccccgca gccaagtcta tgaggacctt gagggttggt     1140

ttcaggcctg agatccgctg gccgggggag gtgggtgtgg gtggaagggc tgggtgtcga     1200

aatcaaacca ccaggcatcc ggcccttacc ggcaagcagc gggctaacgg gaggctgggc     1260

acagaggtca ggaagcaggg gtggggggtg caggtgggca ctggagcatg cagaggaggt     1320

gagagtggga gggaggtaac gggtgcctgc tgcggcagac gggaggggaa aggctgccga     1380

ggaccctccc caccctgaac aaatcttggg tgggtgaagg cctggctgga agagggtgaa     1440

aggcagggcc cttggggctg gggggcaccc cagcctgaag tttgtggggg ccaaacctgg     1500

gaccccgagc ttcctcggta gcagaggccc tgtggtcccc gagacacagg cacgggtccc     1560

tgccacgtcc atagttctga ggtccctgtg tgtaggctgg ggcggggccc aggagaccac     1620

ggggagcaaa ccagcttgtt ctgggctcag ggagggaggg cggtggacaa taaacgtctg     1680

agcagtgaaa aaaaaaaaaa a                                               1701


<210>  10
<211>  342
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Asn Asn Ala Gly His Gly Pro Thr Arg Arg Leu Arg Gly Leu Gly 
1               5                   10                  15      


Val Leu Ala Gly Val Ala Leu Leu Ala Ala Leu Trp Leu Leu Trp Leu 
            20                  25                  30          


Leu Gly Ser Ala Pro Arg Gly Thr Pro Ala Pro Gln Pro Thr Ile Thr 
        35                  40                  45              


Ile Leu Val Trp His Trp Pro Phe Thr Asp Gln Pro Pro Glu Leu Pro 
    50                  55                  60                  


Ser Asp Thr Cys Thr Arg Tyr Gly Ile Ala Arg Cys His Leu Ser Ala 
65                  70                  75                  80  


Asn Arg Ser Leu Leu Ala Ser Ala Asp Ala Val Val Phe His His Arg 
                85                  90                  95      


Glu Leu Gln Thr Arg Arg Ser His Leu Pro Leu Ala Gln Arg Pro Arg 
            100                 105                 110         


Gly Gln Pro Trp Val Trp Ala Ser Met Glu Ser Pro Ser His Thr His 
        115                 120                 125             


Gly Leu Ser His Leu Arg Gly Ile Phe Asn Trp Val Leu Ser Tyr Arg 
    130                 135                 140                 


Arg Asp Ser Asp Ile Phe Val Pro Tyr Gly Arg Leu Glu Pro His Trp 
145                 150                 155                 160 


Gly Pro Ser Pro Pro Leu Pro Ala Lys Ser Arg Val Ala Ala Trp Val 
                165                 170                 175     


Val Ser Asn Phe Gln Glu Arg Gln Leu Arg Ala Arg Leu Tyr Arg Gln 
            180                 185                 190         


Leu Ala Pro His Leu Arg Val Asp Val Phe Gly Arg Ala Asn Gly Arg 
        195                 200                 205             


Pro Leu Cys Ala Ser Cys Leu Val Pro Thr Val Ala Gln Tyr Arg Phe 
    210                 215                 220                 


Tyr Leu Ser Phe Glu Asn Ser Gln His Arg Asp Tyr Ile Thr Glu Lys 
225                 230                 235                 240 


Phe Trp Arg Asn Ala Leu Val Ala Gly Thr Val Pro Val Val Leu Gly 
                245                 250                 255     


Pro Pro Arg Ala Thr Tyr Glu Ala Phe Val Pro Ala Asp Ala Phe Val 
            260                 265                 270         


His Val Asp Asp Phe Gly Ser Ala Arg Glu Leu Ala Ala Phe Leu Thr 
        275                 280                 285             


Gly Met Asn Glu Ser Arg Tyr Gln Arg Phe Phe Ala Trp Arg Asp Arg 
    290                 295                 300                 


Leu Arg Val Arg Leu Phe Thr Asp Trp Arg Glu Arg Phe Cys Ala Ile 
305                 310                 315                 320 


Cys Asp Arg Tyr Pro His Leu Pro Arg Ser Gln Val Tyr Glu Asp Leu 
                325                 330                 335     


Glu Gly Trp Phe Gln Ala 
            340         


