                         SEQUENCE LISTING

<110>  AbbVie Stemcentrx LLC
 
<120>  Anti-ASCL1 Antibodies and Methods of Use

<130>  sc7201WOO1 //  S69697 1410WO

<150>  US 62/339,757
<151>  2016-05-20

<150>  US 62/505,470
<151>  2017-05-12

<160>  73    

<170>  PatentIn version 3.5

<210>  1
<211>  236
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  NP_004307.2 achaete-scute homolog 1 [Homo sapiens]

<400>  1

Met Glu Ser Ser Ala Lys Met Glu Ser Gly Gly Ala Gly Gln Gln Pro 
1               5                   10                  15      


Gln Pro Gln Pro Gln Gln Pro Phe Leu Pro Pro Ala Ala Cys Phe Phe 
            20                  25                  30          


Ala Thr Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Gln 
        35                  40                  45              


Ser Ala Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Ala Pro 
    50                  55                  60                  


Gln Leu Arg Pro Ala Ala Asp Gly Gln Pro Ser Gly Gly Gly His Lys 
65                  70                  75                  80  


Ser Ala Pro Lys Gln Val Lys Arg Gln Arg Ser Ser Ser Pro Glu Leu 
                85                  90                  95      


Met Arg Cys Lys Arg Arg Leu Asn Phe Ser Gly Phe Gly Tyr Ser Leu 
            100                 105                 110         


Pro Gln Gln Gln Pro Ala Ala Val Ala Arg Arg Asn Glu Arg Glu Arg 
        115                 120                 125             


Asn Arg Val Lys Leu Val Asn Leu Gly Phe Ala Thr Leu Arg Glu His 
    130                 135                 140                 


Val Pro Asn Gly Ala Ala Asn Lys Lys Met Ser Lys Val Glu Thr Leu 
145                 150                 155                 160 


Arg Ser Ala Val Glu Tyr Ile Arg Ala Leu Gln Gln Leu Leu Asp Glu 
                165                 170                 175     


His Asp Ala Val Ser Ala Ala Phe Gln Ala Gly Val Leu Ser Pro Thr 
            180                 185                 190         


Ile Ser Pro Asn Tyr Ser Asn Asp Leu Asn Ser Met Ala Gly Ser Pro 
        195                 200                 205             


Val Ser Ser Tyr Ser Ser Asp Glu Gly Ser Tyr Asp Pro Leu Ser Pro 
    210                 215                 220                 


Glu Glu Gln Glu Leu Leu Asp Phe Thr Asn Trp Phe 
225                 230                 235     


<210>  2
<211>  107
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<223>  Murine kappa light chain constant region

<400>  2

Arg Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro Ser Ser Glu 
1               5                   10                  15      


Gln Leu Thr Ser Gly Gly Ala Ser Val Val Cys Phe Leu Asn Asn Phe 
            20                  25                  30          


Tyr Pro Lys Asp Ile Asn Val Lys Trp Lys Ile Asp Gly Ser Glu Arg 
        35                  40                  45              


Gln Asn Gly Val Leu Asn Ser Trp Thr Asp Gln Asp Ser Lys Asp Ser 
    50                  55                  60                  


Thr Tyr Ser Met Ser Ser Thr Leu Thr Leu Thr Lys Asp Glu Tyr Glu 
65                  70                  75                  80  


Arg His Asn Ser Tyr Thr Cys Glu Ala Thr His Lys Thr Ser Thr Ser 
                85                  90                  95      


Pro Ile Val Lys Ser Phe Asn Arg Asn Glu Cys 
            100                 105         


<210>  3
<211>  106
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<223>  Murine lambda light chain constant region

<400>  3

Gly Gln Pro Lys Ser Ser Pro Ser Val Thr Leu Phe Pro Pro Ser Ser 
1               5                   10                  15      


Glu Glu Leu Glu Thr Asn Lys Ala Thr Leu Val Cys Thr Ile Thr Asp 
            20                  25                  30          


Phe Tyr Pro Gly Val Val Thr Val Asp Trp Lys Val Asp Gly Thr Pro 
        35                  40                  45              


Val Thr Gln Gly Met Glu Thr Thr Gln Pro Ser Lys Gln Ser Asn Asn 
    50                  55                  60                  


Lys Tyr Met Ala Ser Ser Tyr Leu Thr Leu Thr Ala Arg Ala Trp Glu 
65                  70                  75                  80  


Arg His Ser Ser Tyr Ser Cys Gln Val Thr His Glu Gly His Thr Val 
                85                  90                  95      


Glu Lys Ser Leu Ser Arg Ala Asp Cys Ser 
            100                 105     


<210>  4
<211>  324
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<223>  IgG1 murine heavy chain constant region

<400>  4

Ala Lys Thr Thr Pro Pro Ser Val Tyr Pro Leu Ala Pro Gly Ser Ala 
1               5                   10                  15      


Ala Gln Thr Asn Ser Met Val Thr Leu Gly Cys Leu Val Lys Gly Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Thr Trp Asn Ser Gly Ser Leu Ser Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Asp Leu Tyr Thr Leu 
    50                  55                  60                  


Ser Ser Ser Val Thr Val Pro Ser Ser Pro Arg Pro Ser Glu Thr Val 
65                  70                  75                  80  


Thr Cys Asn Val Ala His Pro Ala Ser Ser Thr Lys Val Asp Lys Lys 
                85                  90                  95      


Ile Val Pro Arg Asp Cys Gly Cys Lys Pro Cys Ile Cys Thr Val Pro 
            100                 105                 110         


Glu Val Ser Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Val Leu 
        115                 120                 125             


Thr Ile Thr Leu Thr Pro Lys Val Thr Cys Val Val Val Asp Ile Ser 
    130                 135                 140                 


Lys Asp Asp Pro Glu Val Gln Phe Ser Trp Phe Val Asp Asp Val Glu 
145                 150                 155                 160 


Val His Thr Ala Gln Thr Gln Pro Arg Glu Glu Gln Phe Asn Ser Thr 
                165                 170                 175     


Phe Arg Ser Val Ser Glu Leu Pro Ile Met His Gln Asp Trp Leu Asn 
            180                 185                 190         


Gly Lys Glu Phe Lys Cys Arg Val Asn Ser Ala Ala Phe Pro Ala Pro 
        195                 200                 205             


Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Arg Pro Lys Ala Pro Gln 
    210                 215                 220                 


Val Tyr Thr Ile Pro Pro Pro Lys Glu Gln Met Ala Lys Asp Lys Val 
225                 230                 235                 240 


Ser Leu Thr Cys Met Ile Thr Asp Phe Phe Pro Glu Asp Ile Thr Val 
                245                 250                 255     


Glu Trp Gln Trp Asn Gly Gln Pro Ala Glu Asn Tyr Lys Asn Thr Gln 
            260                 265                 270         


Pro Ile Met Asn Thr Asn Gly Ser Tyr Phe Val Tyr Ser Lys Leu Asn 
        275                 280                 285             


Val Gln Lys Ser Asn Trp Glu Ala Gly Asn Thr Phe Thr Cys Ser Val 
    290                 295                 300                 


Leu His Glu Gly Leu His Asn His His Thr Glu Lys Ser Leu Ser His 
305                 310                 315                 320 


Ser Pro Gly Lys 
                


<210>  5
<400>  5
000


<210>  6
<400>  6
000


<210>  7
<400>  7
000

<210>  8
<400>  8
000    


<210>  9
<400>  9
000

<210>  10
<400>  10
000

<210>  11
<400>  11
000    


<210>  12
<400>  12
000     


<210>  13
<400>  13
000

<210>  14
<400>  14
000           


<210>  15
<400>  15
000

<210>  16
<400>  16
000   


<210>  17
<400>  17
000

<210>  18
<400>  18
000


<210>  19
<400>  19
000
    

<210>  20
<211>  339
<212>  DNA
<213>  Mus musculus


<220>
<221>  misc_feature
<223>  SC72.2 & SC72.93 Light Chain Variable Region

<400>  20
gatgttgtga tgacccagac tccactcact ttgtcggtta ccattggaca accagcttcc       60

atctcttgca agtcaagtca gagcctctta gatagtgatg gaaaaaccta tttaaattgg      120

ttattacaga ggccaggcga gtctccaaag ctcctaatct atctggtgtc taaactggac      180

tctggagtcc ctgacaggtt cactggcagt ggatcaggga cagatttcac actgaaaatc      240

agcagagtgg aggctgagga tttgggagtt tattactgct tgcaagctac acattttcct      300

cagctcacgt tcggtgctgg gaccaagctg gagctgaaa                             339


<210>  21
<211>  113
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<223>  SC72.2 & SC72.93 Light Chain Variable Region

<400>  21

Asp Val Val Met Thr Gln Thr Pro Leu Thr Leu Ser Val Thr Ile Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu Asp Ser 
            20                  25                  30          


Asp Gly Lys Thr Tyr Leu Asn Trp Leu Leu Gln Arg Pro Gly Glu Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Leu Val Ser Lys Leu Asp Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Leu Gln Ala 
                85                  90                  95      


Thr His Phe Pro Gln Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu 
            100                 105                 110         


Lys 
    


<210>  22
<211>  342
<212>  DNA
<213>  Mus musculus


<220>
<221>  misc_feature
<223>  SC72.2 Heavy Chain Variable Region

<400>  22
caggttcaac tgcagcagtc tggggctgag ttggtgaggc ctggggcttc agtgacgctg       60

tcctgcaagg cttcgggcta cacatttatt gactatgaaa tgcactgggt gaagcagaca      120

cctgtgcatg gcctggaatg gattggagct attgatcctg aaactggtgg tactacctac      180

aatcagaact tcaagggcaa ggccacactg actgcagaca aatcctccaa cacagcctac      240

atggagctcc gcagcctgac atctggggac tctgccgtct attactgttc aagagggggt      300

cttgactact ggggccaagg caccactctc acagtctcct ca                         342


<210>  23
<211>  114
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<223>  SC72.2 & SC72.93 Heavy Chain Variable Region

<400>  23

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Thr Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ile Asp Tyr 
            20                  25                  30          


Glu Met His Trp Val Lys Gln Thr Pro Val His Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ala Ile Asp Pro Glu Thr Gly Gly Thr Thr Tyr Asn Gln Asn Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Thr Ser Gly Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ser Arg Gly Gly Leu Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val 
            100                 105                 110         


Ser Ser 
        


<210>  24
<211>  336
<212>  DNA
<213>  Mus musculus


<220>
<221>  misc_feature
<223>  SC72.28 Light Chain Variable Region

<400>  24
gatgttgtga tgacccagac tccactcact ttgtcggtta cctttggaca accagcttcc       60

atctcttgta agtcaagtca gagcctctta gatagtgatg gaaaaaccta tttaaattgg      120

ttattacaga ggccaggcga gtctccaaag ctcctaatct atctggtgtc taaactggac      180

tctggagtcc ctgacaggtt cactggcagt ggatcaggga cagatttcac actgaaaatc      240

agcagagtgg aggctgagga tttgggagtt tattactgct tgcaagctac acattttcct      300

ctcacgttcg gtgctgggac caagctggag ctgaaa                                336


<210>  25
<211>  112
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<223>  SC72.28 Light Chain Variable Region

<400>  25

Asp Val Val Met Thr Gln Thr Pro Leu Thr Leu Ser Val Thr Phe Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu Asp Ser 
            20                  25                  30          


Asp Gly Lys Thr Tyr Leu Asn Trp Leu Leu Gln Arg Pro Gly Glu Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Leu Val Ser Lys Leu Asp Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Leu Gln Ala 
                85                  90                  95      


Thr His Phe Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105                 110         


<210>  26
<211>  342
<212>  DNA
<213>  Mus musculus


<220>
<221>  misc_feature
<223>  SC72.28 Heavy Chain Variable Region

<400>  26
gacgttcagc tgcagcagtc tggggctgag cttgtgaggc caggggcctt agtcaagttg       60

tcctgcaaag cttctggctt caacattaaa gactacctta tacactgggt gaagcagagg      120

cctgaacagg gcctggagtg gattggatgt attgatcctg agaatggtaa tactatatat      180

gacccgaggt tccagggcaa ggccaaaata acatcagaca catcctccac cacagcctac      240

ctccggctca ccagcctgac atctgaggac actgccgtct attactgtgg tagggggggc      300

cttgactact ggggccaagg caccactctc acagtctcct ca                         342


<210>  27
<211>  114
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<223>  SC72.28 Heavy Chain Variable Region

<400>  27

Asp Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Leu Val Lys Leu Ser Cys Lys Ala Ser Gly Phe Asn Ile Lys Asp Tyr 
            20                  25                  30          


Leu Ile His Trp Val Lys Gln Arg Pro Glu Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Cys Ile Asp Pro Glu Asn Gly Asn Thr Ile Tyr Asp Pro Arg Phe 
    50                  55                  60                  


Gln Gly Lys Ala Lys Ile Thr Ser Asp Thr Ser Ser Thr Thr Ala Tyr 
65                  70                  75                  80  


Leu Arg Leu Thr Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Gly Arg Gly Gly Leu Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val 
            100                 105                 110         


Ser Ser 
        


<210>  28
<211>  336
<212>  DNA
<213>  Mus musculus


<220>
<221>  misc_feature
<223>  SC72.52 Light Chain Variable Region

<400>  28
gatattgtga taacccagga tgaactctcc aatcctgtca cttctggaga atcagtttcc       60

atctcctgca ggtctagtaa gagtctccta tataaggatg ggaagacata cttgaattgg      120

tttctgcaga gaccaggaca atctcctcag ctcctgatct atttgatgtc cacccgtgca      180

tcaggagtct cagaccggtt tagtggcagt gggtcaggaa cagatttcac cctggaaatc      240

agtagagtga aggctgagga tgtgggtgtg tattactgtc aacaatttgt agagtatccg      300

ctcacgttcg gtgctgggac caagctggag ctgaaa                                336


<210>  29
<211>  112
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<223>  SC72.52 Light Chain Variable Region

<400>  29

Asp Ile Val Ile Thr Gln Asp Glu Leu Ser Asn Pro Val Thr Ser Gly 
1               5                   10                  15      


Glu Ser Val Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu Tyr Lys 
            20                  25                  30          


Asp Gly Lys Thr Tyr Leu Asn Trp Phe Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Leu Met Ser Thr Arg Ala Ser Gly Val Ser 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Glu Ile 
65                  70                  75                  80  


Ser Arg Val Lys Ala Glu Asp Val Gly Val Tyr Tyr Cys Gln Gln Phe 
                85                  90                  95      


Val Glu Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105                 110         


<210>  30
<211>  348
<212>  DNA
<213>  Mus musculus


<220>
<221>  misc_feature
<223>  SC72.52 Heavy Chain Variable Region

<400>  30
caggtccaac tgcagcagcc tgggtctgtg ctggtgaggc ctggagcttc agtgaagctg       60

tcctgcaagg cttctggcta cacattcacc agctactgga tgcactgggt gaagcagagg      120

cctggacaag gccttgagtg gattggagag atttatccta atagtggtag gactaactac      180

aatgagaagt tcaagggcaa ggccacactg actgttgaca catcctccag caccgcctac      240

gtggatctca gcagcctgac atctgaggac tctgcggtct attactgtca ttactacgat      300

gataactacg gctactgggg ccaaggcacc actctcacag tctcctca                   348


<210>  31
<211>  116
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<223>  SC72.52 Heavy Chain Variable Region

<400>  31

Gln Val Gln Leu Gln Gln Pro Gly Ser Val Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Tyr Pro Asn Ser Gly Arg Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Thr Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Val Asp Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


His Tyr Tyr Asp Asp Asn Tyr Gly Tyr Trp Gly Gln Gly Thr Thr Leu 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  32
<211>  321
<212>  DNA
<213>  Mus musculus


<220>
<221>  misc_feature
<223>  SC72.63 Light Chain Variable Region

<400>  32
gacatccaga tgactcagtc tccagcctcc ctatctgcat ctgtgggaga aactgtcacc       60

atgacatgtc gagcaagtga gaatatttac agtaatttag catggtatca gcagaaacag      120

ggaaaatctc ctcagctcct ggtctatgct gcaacaaact tagcagatga tgtgccatca      180

aggttcagtg gcagtggatc aggcacacag ttttctctga agatcaacag cctgcagcct      240

gaagattttg ggatttatta ctgtcatcat ttttacggtt ctcctctcac gttcggtgct      300

gggaccaagc tggagctgaa a                                                321


<210>  33
<211>  107
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<223>  SC72.63 Light Chain Variable Region

<400>  33

Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Glu Thr Val Thr Met Thr Cys Arg Ala Ser Glu Asn Ile Tyr Ser Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Gln Gly Lys Ser Pro Gln Leu Leu Val 
        35                  40                  45              


Tyr Ala Ala Thr Asn Leu Ala Asp Asp Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Gln Phe Ser Leu Lys Ile Asn Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Gly Ile Tyr Tyr Cys His His Phe Tyr Gly Ser Pro Leu 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105         


<210>  34
<211>  357
<212>  DNA
<213>  Mus musculus


<220>
<221>  misc_feature
<223>  SC72.63 Heavy Chain Variable Region

<400>  34
gaggtccagc tgctgcagtc tggacctgag ctggtgaagc ctggggcttc agtgaagatg       60

tcctgcaagg cttctggata cacactcact gactataact tgcactgggt gaagcagagc      120

catgcaaaga gccttgagtg gattggatat attaaccctt acaatggtgt tacttcctac      180

aaccagaggt tcaagggcaa ggccacattg actgtaaaca agtcctccag cacagccttc      240

atggagttcc gcagcctgac atcggaggat tctgcagtct attactgtgt atctctctac      300

tatggtgacg acccgtttgc ttgctggggc caagggactc tggtcactgt ctcaaca         357


<210>  35
<211>  119
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<223>  SC72.63 Heavy Chain Variable Region

<400>  35

Glu Val Gln Leu Leu Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Leu Thr Asp Tyr 
            20                  25                  30          


Asn Leu His Trp Val Lys Gln Ser His Ala Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Tyr Asn Gly Val Thr Ser Tyr Asn Gln Arg Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asn Lys Ser Ser Ser Thr Ala Phe 
65                  70                  75                  80  


Met Glu Phe Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Val Ser Leu Tyr Tyr Gly Asp Asp Pro Phe Ala Cys Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Thr 
        115                 


<210>  36
<211>  333
<212>  DNA
<213>  Mus musculus


<220>
<221>  misc_feature
<223>  SC72.76 Light Chain Variable Region

<400>  36
gacattgtgc tgacacagtc tcctgcttcc ttaactgtat ctctggggca gagggccacc       60

atctcatgca gggccagcca aagtgtcaga acatctaact atagttatat gcactggtac      120

caacagaaac caggacagcc acccaaactc ctcatcaagt atgcatccaa cctagaatct      180

ggggtccctg ccaggttcag tggcagtggg tctgggacag acttcaccct caacatccat      240

cctgtggagg aggaggatac tgcaacatat tactgtcagc accattggga gattccgttc      300

acgttcggag gggggaccaa gctggaaata aaa                                   333


<210>  37
<211>  111
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<223>  SC72.76 Light Chain Variable Region

<400>  37

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Thr Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Gln Ser Val Arg Thr Ser 
            20                  25                  30          


Asn Tyr Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Lys Tyr Ala Ser Asn Leu Glu Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His 
65                  70                  75                  80  


Pro Val Glu Glu Glu Asp Thr Ala Thr Tyr Tyr Cys Gln His His Trp 
                85                  90                  95      


Glu Ile Pro Phe Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  38
<211>  342
<212>  DNA
<213>  Mus musculus


<220>
<221>  misc_feature
<223>  SC72.76 Heavy Chain Variable Region

<400>  38
caggtgcagc tgaaggagtc aggacctggc ctggtggcgc cctcacagag cctgtccatc       60

acctgcacag tctctgattt ctcattaacc aactatgctg tacactgggt tcgccagtct      120

ccaggaaagg gtctggagtg gctgggagtg atatggagtg atggaaacac agactataat      180

gcgcctttca tatctagact gagcatcagc aaggacaact ccaagagcca agttttcttt      240

aaaatgaaca gtctgcaagc tgatgacaca gccatatact actgtgccag ctatggtgat      300

tctgcttact ggggccaagg gactctggtc actgtctctg ca                         342


<210>  39
<211>  114
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<223>  SC72.76 Heavy Chain Variable Region

<400>  39

Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Ile Thr Cys Thr Val Ser Asp Phe Ser Leu Thr Asn Tyr 
            20                  25                  30          


Ala Val His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Ser Asp Gly Asn Thr Asp Tyr Asn Ala Pro Phe Ile 
    50                  55                  60                  


Ser Arg Leu Ser Ile Ser Lys Asp Asn Ser Lys Ser Gln Val Phe Phe 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Ala Asp Asp Thr Ala Ile Tyr Tyr Cys Ala 
                85                  90                  95      


Ser Tyr Gly Asp Ser Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
            100                 105                 110         


Ser Ala 
        


<210>  40
<211>  336
<212>  DNA
<213>  Mus musculus


<220>
<221>  misc_feature
<223>  SC72.91 Light Chain Variable Region

<400>  40
gatgttgtgc tgacccaaac tccactctcc ctgcctgtca gtcttggaga tcaagcctcc       60

atttattgta gatctagtca gagcattgta catagtaatg gaaacaccta tttcgaatgg      120

tacctgcaga aaccaggcca gtctccaaag ctcctgatct acaaagtttc caaccgattg      180

tctggggtcc cagacaggtt cagtggcagt ggttcaggga cagacttcac actcaagatc      240

agcagagtgg aggctgttga tctgggaatt tattactgct ttcaagcttc acatgttccg      300

ttcacgttcg gtgctgggac caagctggag ctgaaa                                336


<210>  41
<211>  112
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<223>  SC72.91 Light Chain Variable Region

<400>  41

Asp Val Val Leu Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Tyr Cys Arg Ser Ser Gln Ser Ile Val His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Phe Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Leu Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Val Asp Leu Gly Ile Tyr Tyr Cys Phe Gln Ala 
                85                  90                  95      


Ser His Val Pro Phe Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105                 110         


<210>  42
<211>  372
<212>  DNA
<213>  Mus musculus


<220>
<221>  misc_feature
<223>  SC72.91 Heavy Chain Variable Region

<400>  42
caggttcagc tgcagcagtc tggacctgag gtggtgaagc ctggggcttc agtgaagttg       60

tcctgcaagg cttctggcta caccttcaca acctacgata taaactgggt gaagcagagg      120

cctggacagg gacttgagtg gattggatgg atttatttta gagatggtac taataagtac      180

aatgagaagt tcaagggcaa ggccacattg actgtagaca catcctccag cacagcgtac      240

atggagctcc acagcctgac atctgaggac tctgcggtct atttctgtgc aagcgtctat      300

gatggttact acgtttcggg atttgatatt atggactatt ggggtcaagg aacctcagtc      360

accgtttcct ca                                                          372


<210>  43
<211>  124
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<223>  SC72.91 Heavy Chain Variable Region

<400>  43

Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Val Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Thr Tyr 
            20                  25                  30          


Asp Ile Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Tyr Phe Arg Asp Gly Thr Asn Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Thr Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu His Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Ser Val Tyr Asp Gly Tyr Tyr Val Ser Gly Phe Asp Ile Met Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120                 


<210>  44
<211>  321
<212>  DNA
<213>  Mus musculus


<220>
<221>  misc_feature
<223>  SC72.94 Light Chain Variable Region

<400>  44
gacatccaaa tgaaccagtc tccatccagt ctgtctgcat ccctcggaga cacaattacc       60

atcacttgcc gtgccagtca gggcattagt atttggttaa gctggtacca gcagaaacca      120

ggaaatattc ctaaactatt gatctataag gcttccaact tgcacacagg agtcccacca      180

agctttagtg gcagtggatc tggaacagat ttcacattaa ctatcagcag cctacagcct      240

gaagacattg ccacttacta ctgtctacag agtcaaagtt atccgtggac gttcggtggg      300

ggcaccaagc tagaaatcaa a                                                321


<210>  45
<211>  107
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<223>  SC72.94 Light Chain Variable Region

<400>  45

Asp Ile Gln Met Asn Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ile Trp 
            20                  25                  30          


Leu Ser Trp Tyr Gln Gln Lys Pro Gly Asn Ile Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Asn Leu His Thr Gly Val Pro Pro Ser Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Leu Gln Ser Gln Ser Tyr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  46
<211>  336
<212>  DNA
<213>  Mus musculus


<220>
<221>  misc_feature
<223>  SC72.94 Heavy Chain Variable Region

<400>  46
caggtccaac tgcagcagcc tgggactgaa ctggtgaagc ctggggcttc agtgaagctg       60

tcctgcaagg cttctgccta caccttcacc agcctctgga ttcactgggt gaagcagagg      120

cctggacaag gccttgagtg gattggagat attaatccta gtattggtga tacttactac      180

aatgagaggt tcaagagcaa ggccacactg actgtagaca aatcctccag cacagcctac      240

atgcagctca gcagcctgac atctgaggac tctgcggttt attattgtac aactggcgac      300

tcctggggcc aaggcaccac tctcacagtc tcctca                                336


<210>  47
<211>  112
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<223>  SC72.94 Heavy Chain Variable Region

<400>  47

Gln Val Gln Leu Gln Gln Pro Gly Thr Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Ala Tyr Thr Phe Thr Ser Leu 
            20                  25                  30          


Trp Ile His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Asp Ile Asn Pro Ser Ile Gly Asp Thr Tyr Tyr Asn Glu Arg Phe 
    50                  55                  60                  


Lys Ser Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Thr Gly Asp Ser Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser 
            100                 105                 110         


<210>  48
<211>  321
<212>  DNA
<213>  Mus musculus


<220>
<221>  misc_feature
<223>  SC72.96 Light Chain Variable Region

<400>  48
gacatccaga tgactcagtc tccagcctcc ctatctgcat ctgtgggaga aactgtcacc       60

atgacatgtc gagcaagtga aaatattcac agtaatttag tatggtatca gcagaaacag      120

ggaaaatctc ctcaactcct ggtctatgct gcaacaaact tagcagatgg tgtgccatca      180

aggttcagtg gcagtggttc aggctcacag ttttctctga agatcgacag cctgcagcct      240

gaagattttg ggagttatct ctgtcaacat ttttatggca ctcctcgtac cttcggtgga      300

ggcaccaagc tggaaatcaa a                                                321


<210>  49
<211>  107
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<223>  SC72.96 Light Chain Variable Region

<400>  49

Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Glu Thr Val Thr Met Thr Cys Arg Ala Ser Glu Asn Ile His Ser Asn 
            20                  25                  30          


Leu Val Trp Tyr Gln Gln Lys Gln Gly Lys Ser Pro Gln Leu Leu Val 
        35                  40                  45              


Tyr Ala Ala Thr Asn Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Ser Gln Phe Ser Leu Lys Ile Asp Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Gly Ser Tyr Leu Cys Gln His Phe Tyr Gly Thr Pro Arg 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  50
<211>  360
<212>  DNA
<213>  Mus musculus


<220>
<221>  misc_feature
<223>  SC72.96 Heavy Chain Variable Region

<400>  50
gaggtccagc tgcaacagtc aggacctgag ctggtgaagc ctggggcttc agtgaagatg       60

tcctgcaagg cttctggata cacactcact gcctacaaca tacactgggt gaagcagagc      120

catggaaaga gccttgagtg gattggattt attaaccctc acagtggtgg aactacctac      180

aacgagaagt tcaagggcaa ggccacattg actgtaaata agtcctccag cacagccaac      240

atggagctcc gcagtctgac atcggaggat tctgcagtct attactgtgc aagtatttat      300

tactacggta gtagctactt tgaccactgg ggccaaggca ccactctcac agtctcctca      360


<210>  51
<211>  120
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<223>  SC72.96 Heavy Chain Variable Region

<400>  51

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Leu Thr Ala Tyr 
            20                  25                  30          


Asn Ile His Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Phe Ile Asn Pro His Ser Gly Gly Thr Thr Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asn Lys Ser Ser Ser Thr Ala Asn 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Ile Tyr Tyr Tyr Gly Ser Ser Tyr Phe Asp His Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Leu Thr Val Ser Ser 
        115                 120 


<210>  52
<211>  339
<212>  DNA
<213>  Mus musculus


<220>
<221>  misc_feature
<223>  SC72.132 Light Chain Variable Region

<400>  52
gacattgtga tgtcacagtc tccatcctcc ctagctgtgt cagttggaga gaaggttact       60

ctgagctgca agtccagtca gaccctttta tatagtagca atcaacagaa ctacttggcc      120

tggtaccaac agaaaccagg gcagtctcct aaactgctga tttactgggc atccactagg      180

gaatctgggg tccctgatcg cttcacaggc agtggatctg ggacagattt cacgctcacc      240

atcagcagtg tgaaggctga agacctggca gtttattact gtcaccaata ttatacgtat      300

ccattcacgt tcggctcggg gacaaagttg gaaataaaa                             339


<210>  53
<211>  113
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<223>  SC72.132 Light Chain Variable Region

<400>  53

Asp Ile Val Met Ser Gln Ser Pro Ser Ser Leu Ala Val Ser Val Gly 
1               5                   10                  15      


Glu Lys Val Thr Leu Ser Cys Lys Ser Ser Gln Thr Leu Leu Tyr Ser 
            20                  25                  30          


Ser Asn Gln Gln Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Lys Ala Glu Asp Leu Ala Val Tyr Tyr Cys His Gln 
                85                  90                  95      


Tyr Tyr Thr Tyr Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  54
<211>  360
<212>  DNA
<213>  Mus musculus


<220>
<221>  misc_feature
<223>  SC72.132 Heavy Chain Variable Region

<400>  54
gaagtgaagc tggtggagtc tgagggaggc ttagtgcagc ctggaagttc catgaaactc       60

tcctgcacag cctctggatt cactttcagt gactattaca tggcttgggt ccgccaggtt      120

ccagaaaagg gtctagaatg ggttgcaacc attgattatg atggtagtaa cacctactat      180

ctggactcct tgaagagccg tttcatcatc tcgagagaca atgcaaagaa cattctatac      240

ctgcaaatga gcagtctgaa gtctgaggac acagccacgt attactgtgc aagagatgga      300

ggttacgacg aggactactt tgactactgg ggccaaggca ccactctcac agtctcctca      360


<210>  55
<211>  120
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<223>  SC72.132 Heavy Chain Variable Region

<400>  55

Glu Val Lys Leu Val Glu Ser Glu Gly Gly Leu Val Gln Pro Gly Ser 
1               5                   10                  15      


Ser Met Lys Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Ala Trp Val Arg Gln Val Pro Glu Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Asp Tyr Asp Gly Ser Asn Thr Tyr Tyr Leu Asp Ser Leu 
    50                  55                  60                  


Lys Ser Arg Phe Ile Ile Ser Arg Asp Asn Ala Lys Asn Ile Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Lys Ser Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Gly Tyr Asp Glu Asp Tyr Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Leu Thr Val Ser Ser 
        115                 120 


<210>  56
<211>  333
<212>  DNA
<213>  Mus musculus


<220>
<221>  misc_feature
<223>  SC72.165 Light Chain Variable Region

<400>  56
gacattgtgc tgacccaatc tccagcttct ttggctgtgt ctccagggca gagggccacc       60

atctcctgca aggccagcca aagtgttggt tatgatggtg atacttattt gagctggtac      120

caacagaaac caggacagcc acccaaactc ctcatctatg gtgtatctat tctagaatct      180

gggatcccag ccaggtttag tggcagtggg tctgggacag acttcaccct caacatccat      240

cctgtggaag aggaggatgc tgcaacctat tactgtcagc aaagtagtga ggatccgtac      300

acgttcggag gggggaccaa gttggagata aaa                                   333


<210>  57
<211>  111
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<223>  SC72.165 Light Chain Variable Region

<400>  57

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Pro Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Lys Ala Ser Gln Ser Val Gly Tyr Asp 
            20                  25                  30          


Gly Asp Thr Tyr Leu Ser Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Gly Val Ser Ile Leu Glu Ser Gly Ile Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His 
65                  70                  75                  80  


Pro Val Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Ser Ser 
                85                  90                  95      


Glu Asp Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  58
<211>  342
<212>  DNA
<213>  Mus musculus


<220>
<221>  misc_feature
<223>  SC72.165 Heavy Chain Variable Region

<400>  58
caggtccaac tgcagcagcc tggtgctgag cttgtgaggc ctggggcctc agtgagactg       60

tcctgcaagg cttctggcta tagtttcacc agctactgga taaactgggt gaagcagagg      120

cctggacaag gccttgagtg gattggaaat atttatcctg gaagtagtaa tactaactac      180

aatgagaagt tcaagaggaa ggccacactg actgtagaca catcctccag cacagcctac      240

atgcagctca gcagcctgac atctgacgac tctgcggtct attattgtgc aagatcggag      300

agtgactact ggggccaagg caccactctc acagtctcct ca                         342


<210>  59
<211>  114
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<223>  SC72.165 Heavy Chain Variable Region

<400>  59

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Arg Leu Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Ser Tyr 
            20                  25                  30          


Trp Ile Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Asn Ile Tyr Pro Gly Ser Ser Asn Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Arg Lys Ala Thr Leu Thr Val Asp Thr Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Asp Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Glu Ser Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val 
            100                 105                 110         


Ser Ser 
        


<210>  60
<211>  333
<212>  DNA
<213>  Mus musculus


<220>
<221>  misc_feature
<223>  SC72.181 Light Chain Variable Region

<400>  60
gacattgtgc tgacccaatc tccagcttct ttggctgtgt ctctagggca gagggccacc       60

atctcctgca aggccagcca aagtgttgat gatgatggtg gtacttatat gagctggtac      120

caacagaaac caggacagcc acccaaactc ctcatctatg gtgtattcat tctagaatct      180

gggatcccag ccaggtttag tggcagtggg tctgggacag acttcaccct caacatccat      240

cctgtggaag aggaggatgc tgcaacctat tactgtcagc aaagtaatga ggatccgtac      300

acgttcggag gggggaccaa gctggaaata aaa                                   333


<210>  61
<211>  111
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<223>  SC72.181 Light Chain Variable Region

<400>  61

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Lys Ala Ser Gln Ser Val Asp Asp Asp 
            20                  25                  30          


Gly Gly Thr Tyr Met Ser Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Gly Val Phe Ile Leu Glu Ser Gly Ile Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His 
65                  70                  75                  80  


Pro Val Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Ser Asn 
                85                  90                  95      


Glu Asp Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  62
<211>  342
<212>  DNA
<213>  Mus musculus


<220>
<221>  misc_feature
<223>  SC72.181 Heavy Chain Variable Region

<400>  62
caggtccaac tgcagcagcc tggtgctgag gttgtgaagc ctggggcctc agtgagactg       60

tcctgcaagg cttctggcta cactttcacc agctactgga taaactgggt gaaacagagg      120

cctggacaag gccttgagtg gattggtaat atttatcctg gtagtagtag tactaactac      180

aatgagaagt tcaagagcaa ggccacactg actgtagaca catcctccag cacagcctac      240

atgcagctca gcagcctgac atctgacgac tctgcggtct attattgttc aagatcggag      300

agtgactact ggggccaagg caccactctc acagtctcct ca                         342


<210>  63
<211>  114
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<223>  SC72.181 Heavy Chain Variable Region

<400>  63

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Val Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Arg Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Ile Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Asn Ile Tyr Pro Gly Ser Ser Ser Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Ser Lys Ala Thr Leu Thr Val Asp Thr Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Asp Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ser Arg Ser Glu Ser Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val 
            100                 105                 110         


Ser Ser 
        


<210>  64
<211>  321
<212>  DNA
<213>  Mus musculus


<220>
<221>  misc_feature
<223>  SC72.201 Light Chain Variable Region

<400>  64
gacatccaga tgactcagtc tccagcctcc ctatctgtat ctgtgggaga aactgtcacc       60

atcacatgtc gagcaagtga aaatatttac agtagtttag catggtatca gcagaaacag      120

ggaaattctc ctcagctcct ggtctatgct gcaacaaagt tagcagatgg tgtgccatca      180

aggttcagtg gcagtggatc aggcacacag tattccctca agatcaacag cctgcagtct      240

gaagattttg ggagttatta ctgtcaacat ttttggggta ctacgtggac gttcggtgga      300

ggcaccaagc tggaaatcaa a                                                321


<210>  65
<211>  107
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<223>  SC72.201 Light Chain Variable Region

<400>  65

Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Val Ser Val Gly 
1               5                   10                  15      


Glu Thr Val Thr Ile Thr Cys Arg Ala Ser Glu Asn Ile Tyr Ser Ser 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Gln Gly Asn Ser Pro Gln Leu Leu Val 
        35                  40                  45              


Tyr Ala Ala Thr Lys Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Gln Tyr Ser Leu Lys Ile Asn Ser Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Phe Gly Ser Tyr Tyr Cys Gln His Phe Trp Gly Thr Thr Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  66
<211>  345
<212>  DNA
<213>  Mus musculus


<220>
<221>  misc_feature
<223>  SC72.201 Heavy Chain Variable Region

<400>  66
gaagtgaacc ttgaggagtc tggaggaggc ttggtgcaac ctggaggatc catgaaactc       60

tcctgtgttg cctctggatt cactttcagt aactactgga tgaactgggt ccgccagtct      120

ccagagaagg ggcttgagtg ggttgctcaa attagatcga aatctgataa ttatgcaaca      180

cattatgcgg agtctgtgaa agggaggttc accatctcaa gagatgattc caaaagtagt      240

gtctacctgc aaatgaacaa cttaaggtct gaagacactg gaatttatta ctgcagaact      300

ggtcccgatg tctggggcac agggaccacg gtcaccgtct cctca                      345


<210>  67
<211>  115
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<223>  SC72.201 Heavy Chain Variable Region

<400>  67

Glu Val Asn Leu Glu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Met Lys Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Arg Gln Ser Pro Glu Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Gln Ile Arg Ser Lys Ser Asp Asn Tyr Ala Thr His Tyr Ala Glu 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ser 
65                  70                  75                  80  


Val Tyr Leu Gln Met Asn Asn Leu Arg Ser Glu Asp Thr Gly Ile Tyr 
                85                  90                  95      


Tyr Cys Arg Thr Gly Pro Asp Val Trp Gly Thr Gly Thr Thr Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  68
<211>  333
<212>  DNA
<213>  Mus musculus


<220>
<221>  misc_feature
<223>  SC72.216 Light Chain Variable Region

<400>  68
gacattgtgg tgacccaatc tccagcttct ttggctgtgt ctctagggca gagggccacc       60

atctcctgca aggccagcca aagtgttgat tatgatggtg atagttatat gaactggtac      120

caacagaaac caggacagcc acccaaactc ctcatctatg gtgcatccaa tctagaatct      180

gggatcccag ccaggtttag tggcagtggg tctgggacag acttcaccct caacatccat      240

cctgtggagg aggaggatgc tgcaacctat tactgtcagc aaagtaatga ggatccgtac      300

acgttcggag gggggaccaa gctggaaata aaa                                   333


<210>  69
<211>  111
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<223>  SC72.216 Light Chain Variable Region

<400>  69

Asp Ile Val Val Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Lys Ala Ser Gln Ser Val Asp Tyr Asp 
            20                  25                  30          


Gly Asp Ser Tyr Met Asn Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Gly Ala Ser Asn Leu Glu Ser Gly Ile Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His 
65                  70                  75                  80  


Pro Val Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Ser Asn 
                85                  90                  95      


Glu Asp Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  70
<211>  360
<212>  DNA
<213>  Mus musculus


<220>
<221>  misc_feature
<223>  SC72.216 Heavy Chain Variable Region

<400>  70
cagatccagt tggtgcagtc tggacctgag ctgaggaagc ctggagagac agtcaagatc       60

tcctgcaagg cttctgggta tacgttcaca aactatccaa tgcactgggt gaaacaggct      120

ccaggaaagg gtttcaagtg gatgggctgg ataaacacct actctggagt gccatcatat      180

gcagatgact tcaagggacg gtttgccttc tctttggaaa cctctgccag ctctgcatat      240

ttgcagatca acaacctcaa aaatgaggac atggctacat atttctgtgc aagacataat      300

tacaatagtt acgacgtgtt tgcttactgg ggccaaggga ctctggtcac tgtctctgca      360


<210>  71
<211>  120
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<223>  SC72.216 Heavy Chain Variable Region

<400>  71

Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Arg Lys Pro Gly Glu 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Pro Met His Trp Val Lys Gln Ala Pro Gly Lys Gly Phe Lys Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Ser Gly Val Pro Ser Tyr Ala Asp Asp Phe 
    50                  55                  60                  


Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser Ser Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Asn Asn Leu Lys Asn Glu Asp Met Ala Thr Tyr Phe Cys 
                85                  90                  95      


Ala Arg His Asn Tyr Asn Ser Tyr Asp Val Phe Ala Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ala 
        115                 120 


<210>  72
<211>  342
<212>  DNA
<213>  Mus musculus


<220>
<221>  misc_feature
<223>  SC72.93 Heavy Chain Variable Region

<400>  72
caggttcaac tgcagcagtc tggggctgag ctggtgaggc ctggggcttc agtgacgctg       60

tcctgcaagg cttcgggcta catatttatt gactatgaaa tgcactgggt gaagcagaca      120

cctgtgcatg gcctggaatg gattggatct attgatcctg agactggtga tactgtctac      180

aatcagaagt tcaagggcaa ggccacactg actgcagaca aatcctccag cacagcctac      240

atggagctcc gcagcctgac atctgaggac tctgccgtct attattgttc aagagggggt      300

cttgactact ggggccaagg caccactctc acagtctcct ca                         342


<210>  73
<211>  114
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<223>  SC72.93 Heavy Chain Variable Region

<400>  73

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Thr Leu Ser Cys Lys Ala Ser Gly Tyr Ile Phe Ile Asp Tyr 
            20                  25                  30          


Glu Met His Trp Val Lys Gln Thr Pro Val His Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ser Ile Asp Pro Glu Thr Gly Asp Thr Val Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ser Arg Gly Gly Leu Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val 
            100                 105                 110         


Ser Ser 
        


