                         SEQUENCE LISTING

<110>  University of Miami
 
<120>  TARGETED DELIVERY OF THERAPEUTIC AGENTS AND IMAGING REAGENTS TO 
       PANCREATIC CANCER CELLS

<130>  32286/50472A PC

<150>  Us 62/338908
<151>  2016-05-19

<160>  10    

<170>  PatentIn version 3.5

<210>  1
<211>  372
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  P2Y1

<400>  1

Thr Glu Val Leu Trp Pro Ala Val Pro Asn Gly Thr Asp Ala Ala Phe 
1               5                   10                  15      


Leu Ala Gly Pro Gly Ser Ser Trp Gly Asn Ser Thr Val Ala Ser Thr 
            20                  25                  30          


Ala Ala Val Ser Ser Ser Phe Lys Cys Ala Leu Thr Lys Thr Gly Phe 
        35                  40                  45              


Gln Phe Tyr Tyr Leu Pro Ala Val Tyr Ile Leu Val Phe Ile Ile Gly 
    50                  55                  60                  


Phe Leu Gly Asn Ser Val Ala Ile Trp Met Phe Val Phe His Met Lys 
65                  70                  75                  80  


Pro Trp Ser Gly Ile Ser Val Tyr Met Phe Asn Leu Ala Leu Ala Asp 
                85                  90                  95      


Phe Leu Tyr Val Leu Thr Leu Pro Ala Leu Ile Phe Tyr Tyr Phe Asn 
            100                 105                 110         


Lys Thr Asp Trp Ile Phe Gly Asp Ala Met Cys Lys Leu Gln Arg Phe 
        115                 120                 125             


Ile Phe His Val Asn Leu Tyr Gly Ser Ile Leu Phe Leu Thr Cys Ile 
    130                 135                 140                 


Ser Ala His Arg Tyr Ser Gly Val Val Tyr Pro Leu Lys Ser Leu Gly 
145                 150                 155                 160 


Arg Leu Lys Lys Lys Asn Ala Ile Cys Ile Ser Val Leu Val Trp Leu 
                165                 170                 175     


Ile Val Val Val Ala Ile Ser Pro Ile Leu Phe Tyr Ser Gly Thr Gly 
            180                 185                 190         


Val Arg Lys Asn Lys Thr Ile Thr Cys Tyr Asp Thr Thr Ser Asp Glu 
        195                 200                 205             


Tyr Leu Arg Ser Tyr Phe Ile Tyr Ser Met Cys Thr Thr Val Ala Met 
    210                 215                 220                 


Phe Cys Val Pro Leu Val Leu Ile Leu Gly Cys Tyr Gly Leu Ile Val 
225                 230                 235                 240 


Arg Ala Leu Ile Tyr Lys Asp Leu Asp Asn Ser Pro Leu Arg Arg Lys 
                245                 250                 255     


Ser Ile Tyr Leu Val Ile Ile Val Leu Thr Val Phe Ala Val Ser Tyr 
            260                 265                 270         


Ile Pro Phe His Val Met Lys Thr Met Asn Leu Arg Ala Arg Leu Asp 
        275                 280                 285             


Phe Gln Thr Pro Ala Met Cys Ala Phe Asn Asp Arg Val Tyr Ala Thr 
    290                 295                 300                 


Tyr Gln Val Thr Arg Gly Leu Ala Ser Leu Asn Ser Cys Val Asp Pro 
305                 310                 315                 320 


Ile Leu Tyr Phe Leu Ala Gly Asp Thr Phe Arg Arg Arg Leu Ser Arg 
                325                 330                 335     


Ala Thr Arg Lys Ala Ser Arg Arg Ser Glu Ala Asn Leu Gln Ser Lys 
            340                 345                 350         


Ser Glu Asp Met Thr Leu Asn Ile Leu Pro Glu Phe Lys Gln Asn Gly 
        355                 360                 365             


Asp Thr Ser Leu 
    370         


<210>  2
<211>  6802
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  P2Y1

<400>  2
acctggcgtg gttctcgagg gccctagagg ctcctgctac ggactggtcg gctctggggt       60

tgtaggcaga aggctctaag cggtcggaag ggtttcctgt gtgtcagcaa cttcactttg      120

ccgagatagc tggcggaaga gggaaggagc gctcgcgggc caatcgcctg ccagcagcca      180

ccttggagcg cacccctctc cctcgccgcc gactccggta gcagcgtgcc ggcagaggct      240

gaacacactc ggcctcggcg gagacctgct ccccagaaga cgcctcctgc ttcccactgc      300

gccctggagg acgcgggctg gctgctgggc gagctcggcg gaggcacgcc cctcgcctcc      360

ccgcggagtg cggactcgcc ccggtgccca aactccgccc accctctagg gagctccgct      420

ctcccgccta accccggcac tccggacaga gctgggcctg gggaaggggt tcctgaacta      480

cgcggacgcc gaacgggacg cgctgcagaa gcgcacgagt ctgcggccac gcgcgctccg      540

atggctgcca ggagctgagc tcagggtggg cggaggaagc ggttagacgc cccgaaactg      600

agctgcacgt ttctaaggta gggaggagga agatgccccc aattaagttg atctttgagc      660

caaggaggct ggggagcagc ctccccaagc tagagccctg cagagcgagt ttcccttgac      720

ctcgctgcgc ctctggcgcg ctctgcagcg cggacccgcg gcccctcggg aaagcgcagt      780

cggaaagtta tccgcggcgg ttccctgcgc gccctgttgt gtaagctcgg cgttgccagc      840

ggacggagaa gttgctggct tgcccgatag cccagttcgg tggcggcccg gggcggattt      900

catggcccgc ggcgaacgcg gggccagagc tggcgtgggc gagcccctgc gcgccccctc      960

ccgcggggat ccagttcgcc tgctcccttc cgctcgctgg cttttccgat gcttgctgcg     1020

cccctggccg ccgctgccct ctcgccgcct cctacccctc ggagccgccg cctaagtcga     1080

ggaggagaga atgaccgagg tgctgtggcc ggctgtcccc aacgggacgg acgctgcctt     1140

cctggccggt ccgggttcgt cctgggggaa cagcacggtc gcctccactg ccgccgtctc     1200

ctcgtcgttc aaatgcgcct tgaccaagac gggcttccag ttttactacc tgccggctgt     1260

ctacatcttg gtattcatca tcggcttcct gggcaacagc gtggccatct ggatgttcgt     1320

cttccacatg aagccctgga gcggcatctc cgtgtacatg ttcaatttgg ctctggccga     1380

cttcttgtac gtgctgactc tgccagccct gatcttctac tacttcaata aaacagactg     1440

gatcttcggg gatgccatgt gtaaactgca gaggttcatc tttcatgtga acctctatgg     1500

cagcatcttg tttctgacat gcatcagtgc ccaccggtac agcggtgtgg tgtaccccct     1560

caagtccctg ggccggctca aaaagaagaa tgcgatctgt atcagcgtgc tggtgtggct     1620

cattgtggtg gtggcgatct cccccatcct cttctactca ggtaccgggg tccgcaaaaa     1680

caaaaccatc acctgttacg acaccacctc agacgagtac ctgcgaagtt atttcatcta     1740

cagcatgtgc acgaccgtgg ccatgttctg tgtccccttg gtgctgattc tgggctgtta     1800

cggattaatt gtgagagctt tgatttacaa agatctggac aactctcctc tgaggagaaa     1860

atcgatttac ctggtaatca ttgtactgac tgtttttgct gtgtcttaca tccctttcca     1920

tgtgatgaaa acgatgaact tgagggcccg gcttgatttt cagaccccag caatgtgtgc     1980

tttcaatgac agggtttatg ccacgtatca ggtgacaaga ggtctagcaa gtctcaacag     2040

ttgtgtggac cccattctct atttcttggc gggagatact ttcagaagga gactctcccg     2100

agccacaagg aaagcttcta gaagaagtga ggcaaatttg caatccaaga gtgaagacat     2160

gaccctcaat attttacctg agttcaagca gaatggagat acaagcctgt gaaggcacaa     2220

gaatctccaa acacctctct gttgtaatat ggtaggatgc ttaacagaat caagtacttt     2280

tcccctcttt aactttctag tttagaaaaa aatcaaacca agaaaatagt gagttaaaaa     2340

aataatagaa gtagaaatgc ccacatccac acttagcttg tttgggtttg ctttcacagt     2400

ctctcttcct tctgactaga agtatgtata ataaaacaat actacctagt taaacattta     2460

ctttctcttt tgcctttaaa atgtgcaggc ttttctgttt aaagtgtgtg tgcacatgag     2520

tactggggct gtttttgata ttagtaattt ctctaagaaa actagccccc tgcaacttga     2580

gtttgtggtt tatctagcct ttattgtttt tttaaaatcc acagtaggaa taaaaaatct     2640

atattctcag aaatatctag catggtatat aacaaaacac taaactcatc agttcatccg     2700

gcatcagatc aatggatctc tgagcggggt gtttttttca gtgtcttata agcatagatg     2760

atagttgact gagtttcttt agggcattga atagacaagt aaagctaatg aatttaaaag     2820

cctgaaaagt gattgttttc cagttatttc tggaaaaggt ctcattatat attgggtgct     2880

aaatgtttga tggggaaagc ctgcatatat tatcgtactg gtaaaatgca ttcaaaataa     2940

ttaaagtgca tgtattttcc ttgtaaacac catgagctct cttagacatc ttgtgataaa     3000

gagcatttac ttgccccact gctgtgcaat gccttaggac tttgtttgtg ttccaggaca     3060

agtgttcact cacatctgta aaaacaattt taagaattgc aaataaatta cagaccaaag     3120

attgagtaaa gtcaaataac tgttagtaag ttgaaggata ttggacagga ggacagtatt     3180

tcagaaaagg agaggttgac agtcatccac aaggcatagc ctccaagtat actctcaaat     3240

gtatgaagca actggggtgg gcagaagaca ttttagaatg agggctttag tttaaattaa     3300

agtcatggtg gagaagactc ttgcttcctc caagtgtttg aaaacacaaa atgcgatatg     3360

aaaagaagaa atagaatttg tataggttgc attgatagaa tgggaagcta taatctttga     3420

ataaacctta catctcaata tttaaagaaa aaacatatat atggagggaa atatagagaa     3480

ttaaagtacc tagatgccat agcactgaaa agtaaagtac tactcaaact actaatagaa     3540

gactattggt cagtgttttc tattatattt gttctctgcc aggtgttaat gaaaaatttg     3600

taaaatgctt caacagtgtt aataatttta atgaatattg aattgctgca tgtctagtcc     3660

ttgaaatggt caaattctat ataatgagaa taacaaggtg agataatgca attgacaatc     3720

ccaaacaaat ccagtgtcaa aggaattttt agttttggaa gctatccctc ataaagtcaa     3780

catcagagtt tgcaactgat ggtggcataa cttgtttgaa agcactttac aagtagagca     3840

acatggggct gtatgttaag gcaagaaaga accttagtgc cccgtggacc ataatgacag     3900

gaaattttca ggtcttgatt tcagttcttg caatgcctat gtagattgag gatttgtgag     3960

accttcagag tagcttcact ttacccaatc tctggccact aagatcaatg aagaaaagct     4020

gtatttaacc ttccaaagca gtgattcttt ttacatgttc agttttaatg cataggatta     4080

tagaaaccaa atcaagaaga aacctactac acctccttat tttgaggaaa gagagggtta     4140

gcaaagttct cacttcatca ggctcaaata acatccgttt tagattccta caagacaaaa     4200

tctaaaatat gtcattactt tattgacctt gttaaacaag atcaatatca ttaaactgac     4260

caagatggaa attacaggac ttgtaccaga cttgaacttg tagcctaatg atacacattt     4320

ttacaatatt tcttcaccat ttagttttct ttcttttagg tctcaggatg ctcagcttaa     4380

tttagagtat gtgttaagta cattgtttca gcgtccagag aattttgtga gtgtggatcc     4440

agtgaggagg tgaacagtaa ctagaaatgc ttgtttacta cttggcatgt tttttccaaa     4500

gtgtttcttc tttagcttca tacatcacat atggacactg atgacatgtg aatgcatgcc     4560

acatagtaac aagaatgatc ttgccaactc cttccaagcc aaaagaagcc tctgggaagg     4620

tgtgccaatg gtgaaaacgt acagagggtc agggtgaagc agtgatctct attggctgaa     4680

aaactgatca ggtcatatga tgattgaagt atgtttattg taagggcaga aatgtgttgg     4740

catttggata aaaaactgct aacattatag aacttattac ctaacaaaat ttcacaccac     4800

aaaaaatatt ttaatggcaa attcaaggtg ttttattgct tacaaatcag catctttgac     4860

tctttgaaca tcaatttgtg tttacattga aatgacaaaa agacaaacta agaagaaata     4920

cagcatgcaa gttggaattc agagttaaaa ccatgatgtt gccgctcagc cagctatgtg     4980

actgttgacc ctttcaagaa cacacatgga tttaaaagtt ggatgacatc cattgttggg     5040

gccttggggg atatggtaaa gcatgaaaac taaacagcca ggagcctgtg aaatctgcta     5100

ctgtattttc caggacttca ttccactcct tggctaaaaa aatcttggaa gtttcacaga     5160

ttatgatgtg gacctgtcac ctgtaaattg tctcaatcta ctcagacaag acactaaact     5220

gtctttggat actatagatg tcagtgctta tagcagctgg aatttggcta gtgacaatgt     5280

ttaaagatgt aatactagtt agtatctatt gaagcttaaa ctttgctggt caggttgtag     5340

ctattgtaaa agtatttatt gaagaagctc acagtccttc agttgtacag actgaaaaac     5400

tttcatgaaa gatccaacat actaatgtaa attatattta ttacaatgta tgatattaat     5460

gtgtcaaact ggtgtatttt acaaaatata taatgcatac ataaataaga gttgtatatt     5520

acagtgcttt tcaaatatca gtgtcttgga atatttaagt cttcacattt tttggtctaa     5580

aatatgaaaa tgtttcatga tacaagtgat taattttccc tagtagtgct tttgcatgtt     5640

tgccttttta tttaagtttt tttctatata gacacaattt ggtgtcagac tatcataaga     5700

tcgatagtga atataaaata tcttagccaa atggggtctg tattgtctac attttatata     5760

ttaaataaaa gtttttgttg tcttttcagg aggtttagag tattgtcact aaatatgatc     5820

aaagcttccc tttccaaatg caaaagtctt gtcctacatt taaagttgat ctgtcatgtt     5880

ttagcagtca agtgggatgg gcattatata aacaacgtta caatgtaagg aaaatcttta     5940

aggagatggg gagagaaaaa ggcagctggt ataatcggtt actgctgctt agttctactt     6000

aattttttgt gttgcttctt cttaaggtga gatagcataa tcttaactgt tttgagatgg     6060

aattttaaag taacacacta ccagcgagtt caacactgct attgatttta atctgttttt     6120

ttttgtttag ttgataactt aaattccaag tttcatagtg ataattgtat attatttggc     6180

tgctgaattc tgttagagtt ttttattctg ttgtacattg tattatacac ataatcacaa     6240

attaatatga aggtgaatat atgttacata tcaaaatttg tgaatttgaa ttatagtatg     6300

ttttagtgct attgcaaaaa atgtttattt ttatattatc tgtgatttta atatagatga     6360

ttgaactaga tttctttttg agtgatagtg ccattgaatg agcagtatgg aaacagtgtt     6420

acttgatatt ttgagctttc tcaggtttat ctaaatcagt ggtagcttaa caaaacccag     6480

actaattgtg tgtaattgta tttttaataa aaggaaagta catttcctat aatagcatag     6540

tactgtttgc atgtaagagt atgcaaaacc ttgtgtgtgt gtgtgtgtgt gtgtgtgtgt     6600

gtgtgtctta gtgtgtgtaa ggcatggcag ccaactttgt atctgctatt tttagtacga     6660

gcagagcttc ataattgtgg tcactagaac tgtacttacc atggacagtt aaaactgaaa     6720

aagactcaat aaaactatga aacatggaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     6780

aaaaaaaaaa aaaaaaaaaa aa                                              6802


<210>  3
<211>  349
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  CEACAM8

<400>  3

Met Gly Pro Ile Ser Ala Pro Ser Cys Arg Trp Arg Ile Pro Trp Gln 
1               5                   10                  15      


Gly Leu Leu Leu Thr Ala Ser Leu Phe Thr Phe Trp Asn Pro Pro Thr 
            20                  25                  30          


Thr Ala Gln Leu Thr Ile Glu Ala Val Pro Ser Asn Ala Ala Glu Gly 
        35                  40                  45              


Lys Glu Val Leu Leu Leu Val His Asn Leu Pro Gln Asp Pro Arg Gly 
    50                  55                  60                  


Tyr Asn Trp Tyr Lys Gly Glu Thr Val Asp Ala Asn Arg Arg Ile Ile 
65                  70                  75                  80  


Gly Tyr Val Ile Ser Asn Gln Gln Ile Thr Pro Gly Pro Ala Tyr Ser 
                85                  90                  95      


Asn Arg Glu Thr Ile Tyr Pro Asn Ala Ser Leu Leu Met Arg Asn Val 
            100                 105                 110         


Thr Arg Asn Asp Thr Gly Ser Tyr Thr Leu Gln Val Ile Lys Leu Asn 
        115                 120                 125             


Leu Met Ser Glu Glu Val Thr Gly Gln Phe Ser Val His Pro Glu Thr 
    130                 135                 140                 


Pro Lys Pro Ser Ile Ser Ser Asn Asn Ser Asn Pro Val Glu Asp Lys 
145                 150                 155                 160 


Asp Ala Val Ala Phe Thr Cys Glu Pro Glu Thr Gln Asn Thr Thr Tyr 
                165                 170                 175     


Leu Trp Trp Val Asn Gly Gln Ser Leu Pro Val Ser Pro Arg Leu Gln 
            180                 185                 190         


Leu Ser Asn Gly Asn Arg Thr Leu Thr Leu Leu Ser Val Thr Arg Asn 
        195                 200                 205             


Asp Val Gly Pro Tyr Glu Cys Glu Ile Gln Asn Pro Ala Ser Ala Asn 
    210                 215                 220                 


Phe Ser Asp Pro Val Thr Leu Asn Val Leu Tyr Gly Pro Asp Ala Pro 
225                 230                 235                 240 


Thr Ile Ser Pro Ser Asp Thr Tyr Tyr His Ala Gly Val Asn Leu Asn 
                245                 250                 255     


Leu Ser Cys His Ala Ala Ser Asn Pro Pro Ser Gln Tyr Ser Trp Ser 
            260                 265                 270         


Val Asn Gly Thr Phe Gln Gln Tyr Thr Gln Lys Leu Phe Ile Pro Asn 
        275                 280                 285             


Ile Thr Thr Lys Asn Ser Gly Ser Tyr Ala Cys His Thr Thr Asn Ser 
    290                 295                 300                 


Ala Thr Gly Arg Asn Arg Thr Thr Val Arg Met Ile Thr Val Ser Asp 
305                 310                 315                 320 


Ala Leu Val Gln Gly Ser Ser Pro Gly Leu Ser Ala Arg Ala Thr Val 
                325                 330                 335     


Ser Ile Met Ile Gly Val Leu Ala Arg Val Ala Leu Ile 
            340                 345                 


<210>  4
<211>  2333
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  CEACAM8

<400>  4
agcacaaaag gaggaaggac agcacagctg acagccgtgc tcagaaagtt tctggatccc       60

aggctcatct ccacagagga gaacacgcag gcagcagaga ccatggggcc catctcagcc      120

ccttcctgca gatggcgcat cccctggcag gggctcctgc tcacagcctc acttttcacc      180

ttctggaacc cgcccaccac tgctcagctc actattgaag ctgtgccatc caatgctgca      240

gaggggaagg aggttcttct acttgtccac aatctgcccc aggaccctcg tggctacaac      300

tggtacaaag gggaaacagt ggatgccaac cgtcgaatta taggatatgt aatatcaaat      360

caacagatta ccccagggcc tgcatacagc aatcgagaga caatataccc caatgcatcc      420

ctgctgatgc ggaacgtcac cagaaatgac acaggatcct acaccctaca agtcataaag      480

ctaaatctta tgagtgaaga agtaactggc cagttcagcg tacatccgga gactcccaag      540

ccctccatct ccagcaacaa ctccaacccc gtggaggaca aggatgctgt ggccttcacc      600

tgtgaacctg agactcagaa cacaacctac ctgtggtggg taaatggtca gagtctcccg      660

gtcagtccca ggctgcagct gtccaatggc aacaggaccc tcactctact cagtgtcaca      720

aggaatgacg taggacccta tgaatgtgaa atacagaacc cagcgagtgc aaacttcagt      780

gacccagtca ccctgaatgt cctctatggc ccagatgccc ccaccatttc cccttcagac      840

acctattacc atgcaggggt aaatctcaac ctctcctgcc atgcggcctc taatccaccc      900

tcacagtatt cttggtctgt caatggcaca ttccagcaat acacacaaaa gctctttatc      960

cccaacatca ctacaaagaa cagcggatcc tatgcctgcc acaccactaa ctcagccact     1020

ggccgcaaca ggaccacagt caggatgatc acagtctctg atgctttagt acaaggaagt     1080

tctcctggcc tctcagctag agccactgtc agcatcatga ttggagtact ggccagggtg     1140

gctctgatat agtagctctg gtgtagtttc tgcatttcaa gaagactggc agacagttgt     1200

ttttattctt cctcaaagca tttgcaatca gctaccattc aaaattgctt cttcttcaag     1260

atttatggaa aatactctga cgagtactct tgaacacaag ttcctgataa ctttaagatc     1320

acgccactgg actgtctatg aacttgcaaa caggctgata cctttgtgaa gttgcccacc     1380

aaaacacaga aggaaaaaaa catgaatttc attgaactaa ataataatga ggataatgtt     1440

tttaagattt tttttttttt ttttttgaga tggaatctcg ctctgtcgcc caggctggag     1500

tgcagtggca cgatctcaac tcactgcaag ctccgcctcc tgggttcaca ccattctcct     1560

gcctcagcct cctgagtagc tgggactaca ggcgcctgcc acaacgcccg gctaattttt     1620

tgtattttta gtagagacgg ggtttcactg tggtctcaat ctcctgactt catggtccgc     1680

ctgcctcagc ctcccaaagt tctgggatta caggtgtgag ccaccgcgcc cagcccgttt     1740

ttaagatttt ttatttgaaa aattgccaat tctttaagtg ttttcttttt cagatttatg     1800

aatttcttta tcttttaagc tatctatacc ttactgcaat ttggtaaagc agacttttgt     1860

gaacaaaaat tataacattt acttttgctc cctacctgac tgccacagaa ctgggcaact     1920

attcatgagt attcatatgt ttatggtaat tcagttattt gcacaagttc agtgagaatc     1980

tgctgtcttt ataatgggat atagtttaaa acattggtta tattaccaag gctttgattg     2040

ggatgttata tttgagaaaa tacagagaat gatagattaa cggagtgtct aatctatcgt     2100

gtcaacccca aatttttacg tatgagatcc tttagtccac ccaatggctg acagtaacag     2160

catctttaac acaactcttt gttcaaatgt actatggtct cttttagagt cagactccta     2220

gactcacttg ttctcactgt ctgttttaat ttaacccagg catgcaatgc tagataataa     2280

aattgctccc tattggctga tcaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaa            2333


<210>  5
<211>  344
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  CEACAM6

<400>  5

Met Gly Pro Pro Ser Ala Pro Pro Cys Arg Leu His Val Pro Trp Lys 
1               5                   10                  15      


Glu Val Leu Leu Thr Ala Ser Leu Leu Thr Phe Trp Asn Pro Pro Thr 
            20                  25                  30          


Thr Ala Lys Leu Thr Ile Glu Ser Thr Pro Phe Asn Val Ala Glu Gly 
        35                  40                  45              


Lys Glu Val Leu Leu Leu Ala His Asn Leu Pro Gln Asn Arg Ile Gly 
    50                  55                  60                  


Tyr Ser Trp Tyr Lys Gly Glu Arg Val Asp Gly Asn Ser Leu Ile Val 
65                  70                  75                  80  


Gly Tyr Val Ile Gly Thr Gln Gln Ala Thr Pro Gly Pro Ala Tyr Ser 
                85                  90                  95      


Gly Arg Glu Thr Ile Tyr Pro Asn Ala Ser Leu Leu Ile Gln Asn Val 
            100                 105                 110         


Thr Gln Asn Asp Thr Gly Phe Tyr Thr Leu Gln Val Ile Lys Ser Asp 
        115                 120                 125             


Leu Val Asn Glu Glu Ala Thr Gly Gln Phe His Val Tyr Pro Glu Leu 
    130                 135                 140                 


Pro Lys Pro Ser Ile Ser Ser Asn Asn Ser Asn Pro Val Glu Asp Lys 
145                 150                 155                 160 


Asp Ala Val Ala Phe Thr Cys Glu Pro Glu Val Gln Asn Thr Thr Tyr 
                165                 170                 175     


Leu Trp Trp Val Asn Gly Gln Ser Leu Pro Val Ser Pro Arg Leu Gln 
            180                 185                 190         


Leu Ser Asn Gly Asn Met Thr Leu Thr Leu Leu Ser Val Lys Arg Asn 
        195                 200                 205             


Asp Ala Gly Ser Tyr Glu Cys Glu Ile Gln Asn Pro Ala Ser Ala Asn 
    210                 215                 220                 


Arg Ser Asp Pro Val Thr Leu Asn Val Leu Tyr Gly Pro Asp Gly Pro 
225                 230                 235                 240 


Thr Ile Ser Pro Ser Lys Ala Asn Tyr Arg Pro Gly Glu Asn Leu Asn 
                245                 250                 255     


Leu Ser Cys His Ala Ala Ser Asn Pro Pro Ala Gln Tyr Ser Trp Phe 
            260                 265                 270         


Ile Asn Gly Thr Phe Gln Gln Ser Thr Gln Glu Leu Phe Ile Pro Asn 
        275                 280                 285             


Ile Thr Val Asn Asn Ser Gly Ser Tyr Met Cys Gln Ala His Asn Ser 
    290                 295                 300                 


Ala Thr Gly Leu Asn Arg Thr Thr Val Thr Met Ile Thr Val Ser Gly 
305                 310                 315                 320 


Ser Ala Pro Val Leu Ser Ala Val Ala Thr Val Gly Ile Thr Ile Gly 
                325                 330                 335     


Val Leu Ala Arg Val Ala Leu Ile 
            340                 


<210>  6
<211>  2601
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  CEACAM6

<400>  6
gaggctcagc acagaaggag gaaggacagc agggccaaca gtcacagcag ccctgaccag       60

agcattcctg gagctcaagc tcctctacaa agaggtggac agagaagaca gcagagacca      120

tgggaccccc ctcagcccct ccctgcagat tgcatgtccc ctggaaggag gtcctgctca      180

cagcctcact tctaaccttc tggaacccac ccaccactgc caagctcact attgaatcca      240

cgccgttcaa tgtcgcagag gggaaggagg ttcttctact cgcccacaac ctgccccaga      300

atcgtattgg ttacagctgg tacaaaggcg aaagagtgga tggcaacagt ctaattgtag      360

gatatgtaat aggaactcaa caagctaccc cagggcccgc atacagtggt cgagagacaa      420

tataccccaa tgcatccctg ctgatccaga acgtcaccca gaatgacaca ggattctata      480

ccctacaagt cataaagtca gatcttgtga atgaagaagc aaccggacag ttccatgtat      540

acccggagct gcccaagccc tccatctcca gcaacaactc caaccccgtg gaggacaagg      600

atgctgtggc cttcacctgt gaacctgagg ttcagaacac aacctacctg tggtgggtaa      660

atggtcagag cctcccggtc agtcccaggc tgcagctgtc caatggcaac atgaccctca      720

ctctactcag cgtcaaaagg aacgatgcag gatcctatga atgtgaaata cagaacccag      780

cgagtgccaa ccgcagtgac ccagtcaccc tgaatgtcct ctatggccca gatgtcccca      840

ccatttcccc ctcaaaggcc aattaccgtc caggggaaaa tctgaacctc tcctgccacg      900

cagcctctaa cccacctgca cagtactctt ggtttatcaa tgggacgttc cagcaatcca      960

cacaagagct ctttatcccc aacatcactg tgaataatag cggatcctat atgtgccaag     1020

cccataactc agccactggc ctcaatagga ccacagtcac gatgatcaca gtctctggaa     1080

gtgctcctgt cctctcagct gtggccaccg tcggcatcac gattggagtg ctggccaggg     1140

tggctctgat atagcagccc tggtgtattt tcgatatttc aggaagactg gcagattgga     1200

ccagaccctg aattcttcta gctcctccaa tcccatttta tcccatggaa ccactaaaaa     1260

caaggtctgc tctgctcctg aagccctata tgctggagat ggacaactca atgaaaattt     1320

aaagggaaaa ccctcaggcc tgaggtgtgt gccactcaga gacttcacct aactagagac     1380

agtcaaactg caaaccatgg tgagaaattg acgacttcac actatggaca gcttttccca     1440

agatgtcaaa acaagactcc tcatcatgat aaggctctta ccccctttta atttgtcctt     1500

gcttatgcct gcctctttcg cttggcagga tgatgctgtc attagtattt cacaagaagt     1560

agcttcagag ggtaacttaa cagagtgtca gatctatctt gtcaatccca acgttttaca     1620

taaaataaga gatcctttag tgcacccagt gactgacatt agcagcatct ttaacacagc     1680

cgtgtgttca aatgtacagt ggtccttttc agagttggac ttctagactc acctgttctc     1740

actccctgtt ttaattcaac ccagccatgc aatgccaaat aatagaattg ctccctacca     1800

gctgaacagg gaggagtctg tgcagtttct gacacttgtt gttgaacatg gctaaataca     1860

atgggtatcg ctgagactaa gttgtagaaa ttaacaaatg tgctgcttgg ttaaaatggc     1920

tacactcatc tgactcattc tttattctat tttagttggt ttgtatcttg cctaaggtgc     1980

gtagtccaac tcttggtatt accctcctaa tagtcatact agtagtcata ctccctggtg     2040

tagtgtattc tctaaaagct ttaaatgtct gcatgcagcc agccatcaaa tagtgaatgg     2100

tctctctttg gctggaatta caaaactcag agaaatgtgt catcaggaga acatcataac     2160

ccatgaagga taaaagcccc aaatggtggt aactgataat agcactaatg ctttaagatt     2220

tggtcacact ctcacctagg tgagcgcatt gagccagtgg tgctaaatgc tacatactcc     2280

aactgaaatg ttaaggaaga agatagatcc aattaaaaaa aattaaaacc aatttaaaaa     2340

aaaaaagaac acaggagatt ccagtctact tgagttagca taatacagaa gtcccctcta     2400

ctttaacttt tacaaaaaag taacctgaac taatctgatg ttaaccaatg tatttatttc     2460

tgtggttctg tttccttgtt ccaatttgac aaaacccact gttcttgtat tgtattgccc     2520

agggggagct atcactgtac ttgtagagtg gtgctgcttt aattcataaa tcacaaataa     2580

aagccaatta gctctataac t                                               2601


<210>  7
<211>  622
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  MSLN

<400>  7

Met Ala Leu Pro Thr Ala Arg Pro Leu Leu Gly Ser Cys Gly Thr Pro 
1               5                   10                  15      


Ala Leu Gly Ser Leu Leu Phe Leu Leu Phe Ser Leu Gly Trp Val Gln 
            20                  25                  30          


Pro Ser Arg Thr Leu Ala Gly Glu Thr Gly Gln Glu Ala Ala Pro Leu 
        35                  40                  45              


Asp Gly Val Leu Ala Asn Pro Pro Asn Ile Ser Ser Leu Ser Pro Arg 
    50                  55                  60                  


Gln Leu Leu Gly Phe Pro Cys Ala Glu Val Ser Gly Leu Ser Thr Glu 
65                  70                  75                  80  


Arg Val Arg Glu Leu Ala Val Ala Leu Ala Gln Lys Asn Val Lys Leu 
                85                  90                  95      


Ser Thr Glu Gln Leu Arg Cys Leu Ala His Arg Leu Ser Glu Pro Pro 
            100                 105                 110         


Glu Asp Leu Asp Ala Leu Pro Leu Asp Leu Leu Leu Phe Leu Asn Pro 
        115                 120                 125             


Asp Ala Phe Ser Gly Pro Gln Ala Cys Thr Arg Phe Phe Ser Arg Ile 
    130                 135                 140                 


Thr Lys Ala Asn Val Asp Leu Leu Pro Arg Gly Ala Pro Glu Arg Gln 
145                 150                 155                 160 


Arg Leu Leu Pro Ala Ala Leu Ala Cys Trp Gly Val Arg Gly Ser Leu 
                165                 170                 175     


Leu Ser Glu Ala Asp Val Arg Ala Leu Gly Gly Leu Ala Cys Asp Leu 
            180                 185                 190         


Pro Gly Arg Phe Val Ala Glu Ser Ala Glu Val Leu Leu Pro Arg Leu 
        195                 200                 205             


Val Ser Cys Pro Gly Pro Leu Asp Gln Asp Gln Gln Glu Ala Ala Arg 
    210                 215                 220                 


Ala Ala Leu Gln Gly Gly Gly Pro Pro Tyr Gly Pro Pro Ser Thr Trp 
225                 230                 235                 240 


Ser Val Ser Thr Met Asp Ala Leu Arg Gly Leu Leu Pro Val Leu Gly 
                245                 250                 255     


Gln Pro Ile Ile Arg Ser Ile Pro Gln Gly Ile Val Ala Ala Trp Arg 
            260                 265                 270         


Gln Arg Ser Ser Arg Asp Pro Ser Trp Arg Gln Pro Glu Arg Thr Ile 
        275                 280                 285             


Leu Arg Pro Arg Phe Arg Arg Glu Val Glu Lys Thr Ala Cys Pro Ser 
    290                 295                 300                 


Gly Lys Lys Ala Arg Glu Ile Asp Glu Ser Leu Ile Phe Tyr Lys Lys 
305                 310                 315                 320 


Trp Glu Leu Glu Ala Cys Val Asp Ala Ala Leu Leu Ala Thr Gln Met 
                325                 330                 335     


Asp Arg Val Asn Ala Ile Pro Phe Thr Tyr Glu Gln Leu Asp Val Leu 
            340                 345                 350         


Lys His Lys Leu Asp Glu Leu Tyr Pro Gln Gly Tyr Pro Glu Ser Val 
        355                 360                 365             


Ile Gln His Leu Gly Tyr Leu Phe Leu Lys Met Ser Pro Glu Asp Ile 
    370                 375                 380                 


Arg Lys Trp Asn Val Thr Ser Leu Glu Thr Leu Lys Ala Leu Leu Glu 
385                 390                 395                 400 


Val Asn Lys Gly His Glu Met Ser Pro Gln Val Ala Thr Leu Ile Asp 
                405                 410                 415     


Arg Phe Val Lys Gly Arg Gly Gln Leu Asp Lys Asp Thr Leu Asp Thr 
            420                 425                 430         


Leu Thr Ala Phe Tyr Pro Gly Tyr Leu Cys Ser Leu Ser Pro Glu Glu 
        435                 440                 445             


Leu Ser Ser Val Pro Pro Ser Ser Ile Trp Ala Val Arg Pro Gln Asp 
    450                 455                 460                 


Leu Asp Thr Cys Asp Pro Arg Gln Leu Asp Val Leu Tyr Pro Lys Ala 
465                 470                 475                 480 


Arg Leu Ala Phe Gln Asn Met Asn Gly Ser Glu Tyr Phe Val Lys Ile 
                485                 490                 495     


Gln Ser Phe Leu Gly Gly Ala Pro Thr Glu Asp Leu Lys Ala Leu Ser 
            500                 505                 510         


Gln Gln Asn Val Ser Met Asp Leu Ala Thr Phe Met Lys Leu Arg Thr 
        515                 520                 525             


Asp Ala Val Leu Pro Leu Thr Val Ala Glu Val Gln Lys Leu Leu Gly 
    530                 535                 540                 


Pro His Val Glu Gly Leu Lys Ala Glu Glu Arg His Arg Pro Val Arg 
545                 550                 555                 560 


Asp Trp Ile Leu Arg Gln Arg Gln Asp Asp Leu Asp Thr Leu Gly Leu 
                565                 570                 575     


Gly Leu Gln Gly Gly Ile Pro Asn Gly Tyr Leu Val Leu Asp Leu Ser 
            580                 585                 590         


Met Gln Glu Ala Leu Ser Gly Thr Pro Cys Leu Leu Gly Pro Gly Pro 
        595                 600                 605             


Val Leu Thr Val Leu Ala Leu Leu Leu Ala Ser Thr Leu Ala 
    610                 615                 620         


<210>  8
<211>  2184
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  MSLN

<400>  8
tgccaggctc tccaccccca cttcccaatt gaggaaaccg aggcagagga ggctcagcgc       60

cacgcactcc tctttctgcc tggccggcca ctcccgtctg ctgtgacgcg cggacagaga      120

gctaccggtg gacccacggt gcctccctcc ctgggatcta cacagaccat ggccttgcca      180

acggctcgac ccctgttggg gtcctgtggg acccccgccc tcggcagcct cctgttcctg      240

ctcttcagcc tcggatgggt gcagccctcg aggaccctgg ctggagagac agggcaggag      300

gctgcgcccc tggacggagt cctggccaac ccacctaaca tttccagcct ctcccctcgc      360

caactccttg gcttcccgtg tgcggaggtg tccggcctga gcacggagcg tgtccgggag      420

ctggctgtgg ccttggcaca gaagaatgtc aagctctcaa cagagcagct gcgctgtctg      480

gctcaccggc tctctgagcc ccccgaggac ctggacgccc tcccattgga cctgctgcta      540

ttcctcaacc cagatgcgtt ctcggggccc caggcctgca cccatttctt ctcccgcatc      600

acgaaagcca atgtggacct gctcccgagg ggggctcccg agcgacagcg gctgctgcct      660

gcggctctgg cctgctgggg tgtgcggggg tctctgctga gcgaggctga tgtgcgggct      720

ctgggaggcc tggcttgcga cctgcctggg cgctttgtgg ccgagtcggc cgaagtgctg      780

ctaccccggc tggtgagctg cccgggaccc ctggaccagg accagcagga ggcagccagg      840

gcggctctgc agggcggggg acccccctac ggccccccgt cgacatggtc tgtctccacg      900

atggacgctc tgcggggcct gctgcccgtg ctgggccagc ccatcatccg cagcatcccg      960

cagggcatcg tggccgcgtg gcggcaacgc tcctctcggg acccatcctg gcggcagcct     1020

gaacggacca tcctccggcc gcggttccgg cgggaagtgg agaagacagc ctgtccttca     1080

ggcaagaagg cccgcgagat agacgagagc ctcatcttct acaagaagtg ggagctggaa     1140

gcctgcgtgg atgcggccct gctggccacc cagatggacc gcgtgaacgc catccccttc     1200

acctacgagc agctggacgt cctaaagcat aaactggatg agctctaccc acaaggttac     1260

cccgagtctg tgatccagca cctgggctac ctcttcctca agatgagccc tgaggacatt     1320

cgcaagtgga atgtgacgtc cctggagacc ctgaaggctt tgcttgaagt caacaaaggg     1380

cacgaaatga gtcctcaggt ggccaccctg atcgaccgct ttgtgaaggg aaggggccag     1440

ctagacaaag acaccctaga caccctgacc gccttctacc ctgggtacct gtgctccctc     1500

agccccgagg agctgagctc cgtgcccccc agcagcatct gggcggtcag gccccaggac     1560

ctggacacgt gtgacccaag gcagctggac gtcctctatc ccaaggcccg ccttgctttc     1620

cagaacatga acgggtccga atacttcgtg aagatccagt ccttcctggg tggggccccc     1680

acggaggatt tgaaggcgct tagtcagcag aatgtgagca tggacttggc cacgttcatg     1740

aagctgcgga cggatgcggt gctgccgttg actgtggctg aggtgcagaa acttctggga     1800

ccccacgtgg agggcctgaa ggcggaggag cggcaccgcc cggtgcggga ctggatccta     1860

cggcagcggc aggacgacct ggacacgctg gggctggggc tacagggcgg catccccaac     1920

ggctacctgg tcctagacct cagcgtgcaa gaggccctct cggggacgcc ctgcctccta     1980

ggacctggac ctgttctcac cgtcctggca ctgctcctag cctccaccct ggcctgaggg     2040

ccccactccc ttgctggccc cagccctgct ggggatcccc gcctggccag gagcaggcac     2100

gggtggtccc tgttccaccc caagagaact cgcgctcagt aaacgggaac atgccccctg     2160

caaaaaaaaa aaaaaaaaaa aaaa                                            2184


<210>  9
<211>  283
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  PDX1

<400>  9

Met Asn Gly Glu Glu Gln Tyr Tyr Ala Ala Thr Gln Leu Tyr Lys Asp 
1               5                   10                  15      


Pro Cys Ala Phe Gln Arg Gly Pro Ala Pro Glu Phe Ser Ala Ser Pro 
            20                  25                  30          


Pro Ala Cys Leu Tyr Met Gly Arg Gln Pro Pro Pro Pro Pro Pro His 
        35                  40                  45              


Pro Phe Pro Gly Ala Leu Gly Ala Leu Glu Gln Gly Ser Pro Pro Asp 
    50                  55                  60                  


Ile Ser Pro Tyr Glu Val Pro Pro Leu Ala Asp Asp Pro Ala Val Ala 
65                  70                  75                  80  


His Leu His His His Leu Pro Ala Gln Leu Ala Leu Pro His Pro Pro 
                85                  90                  95      


Ala Gly Pro Phe Pro Glu Gly Ala Glu Pro Gly Val Leu Glu Glu Pro 
            100                 105                 110         


Asn Arg Val Gln Leu Pro Phe Pro Trp Met Lys Ser Thr Lys Ala His 
        115                 120                 125             


Ala Trp Lys Gly Gln Trp Ala Gly Gly Ala Tyr Ala Ala Glu Pro Glu 
    130                 135                 140                 


Glu Asn Lys Arg Thr Arg Thr Ala Tyr Thr Arg Ala Gln Leu Leu Glu 
145                 150                 155                 160 


Leu Glu Lys Glu Phe Leu Phe Asn Lys Tyr Ile Ser Arg Pro Arg Arg 
                165                 170                 175     


Val Glu Leu Ala Val Met Leu Asn Leu Thr Glu Arg His Ile Lys Ile 
            180                 185                 190         


Trp Phe Gln Asn Arg Arg Met Lys Trp Lys Lys Glu Glu Asp Lys Lys 
        195                 200                 205             


Arg Gly Gly Gly Thr Ala Val Gly Gly Gly Gly Val Ala Glu Pro Glu 
    210                 215                 220                 


Gln Asp Cys Ala Val Thr Ser Gly Glu Glu Leu Leu Ala Leu Pro Pro 
225                 230                 235                 240 


Pro Pro Pro Pro Gly Gly Ala Val Pro Pro Ala Ala Pro Val Ala Ala 
                245                 250                 255     


Arg Glu Gly Arg Leu Pro Pro Gly Leu Ser Ala Ser Pro Gln Pro Ser 
            260                 265                 270         


Ser Val Ala Pro Arg Arg Pro Gln Glu Pro Arg 
        275                 280             


<210>  10
<211>  2573
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  PDX1

<400>  10
gggtggcgcc gggagtggga acgccacaca gtgccaaatc cccggctcca gctcccgact       60

cccggctccc ggctcccggc tcccggtgcc caatcccggg ccgcagccat gaacggcgag      120

gagcagtact acgcggccac gcagctttac aaggacccat gcgcgttcca gcgaggcccg      180

gcgccggagt tcagcgccag cccccctgcg tgcctgtaca tgggccgcca gcccccgccg      240

ccgccgccgc acccgttccc tggcgccctg ggcgcgctgg agcagggcag ccccccggac      300

atctccccgt acgaggtgcc ccccctcgcc gacgaccccg cggtggcgca ccttcaccac      360

cacctcccgg ctcagctcgc gctcccccac ccgcccgccg ggcccttccc ggagggagcc      420

gagccgggcg tcctggagga gcccaaccgc gtccagctgc ctttcccatg gatgaagtct      480

accaaagctc acgcgtggaa aggccagtgg gcaggcggcg cctacgctgc ggagccggag      540

gagaacaagc ggacgcgcac ggcctacacg cgcgcacagc tgctagagct ggagaaggag      600

ttcctattca acaagtacat ctcacggccg cgccgggtgg agctggctgt catgttgaac      660

ttgaccgaga gacacatcaa gatctggttc caaaaccgcc gcatgaagtg gaaaaaggag      720

gaggacaaga agcgcggcgg cgggacagct gtcgggggtg gcggggtcgc ggagcctgag      780

caggactgcg ccgtgacctc cggcgaggag cttctggcgc tgccgccgcc gccgcccccc      840

ggaggtgctg tgccgcccgc tgcccccgtt gccgcccgag agggccgcct gccgcctggc      900

cttagcgcgt cgccacagcc ctccagcgtc gcgcctcggc ggccgcagga accacgatga      960

gaggcaggag ctgctcctgg ctgaggggct tcaaccactc gccgaggagg agcagagggc     1020

ctaggaggac cccgggcgtg gaccacccgc cctggcagtt gaatggggcg gcaattgcgg     1080

ggcccacctt agaccgaagg ggaaaacccg ctctctcagg cgcatgtgcc agttggggcc     1140

ccgcgggtag atgccggcag gccttccgga agaaaaagag ccattggttt ttgtagtatt     1200

ggggccctct tttagtgata ctggattggc gttgtttgtg gctgttgcgc acatccctgc     1260

cctcctacag cactccacct tgggacctgt ttagagaagc cggctcttca aagacaatgg     1320

aaactgtacc atacacattg gaaggctccc taacacacac agcggggaag ctgggccgag     1380

taccttaatc tgccataaag ccattcttac tcgggcgacc cctttaagtt tagaaataat     1440

tgaaaggaaa tgtttgagtt ttcaaagatc ccgtgaaatt gatgccagtg gaatacagtg     1500

agtcctcctc ttcctcctcc tcctcttccc cctccccttc ctcctcctcc tcttcttttc     1560

cctcctcttc ctcttcctcc tgctctcctt tcctccccct cctcttttcc ctcctcttcc     1620

tcttcctcct gctctccttt cctccccctc ctctttctcc tcctcctcct cttcttcccc     1680

ctcctctccc tcctcctctt cttccccctc ctctccctcc tcctcttctt ctccctcctc     1740

ttcctcttcc tcctcttcca cgtgctctcc tttcctcccc ctcctcttgc tccccttctt     1800

ccccgtcctc ttcctcctcc tcctcttctt ctccctcctc ttcctcctcc tctttcttcc     1860

tgacctcttt ctttctcctc ctcctccttc tacctcccct tctcatccct cctcttcctc     1920

ttctctagct gcacacttca ctactgcaca tcttataact tgcacccctt tcttctgagg     1980

aagagaacat cttgcaaggc agggcgagca gcggcagggc tggcttagga gcagtgcaag     2040

agtccctgtg ctccagttcc acactgctgg cagggaaggc aaggggggac gggcctggat     2100

ctgggggtga gggagaaaga tggacccctg ggtgaccact aaaccaaaga tattcggaac     2160

tttctattta ggatgtggac gtaattcctg ttccgaggta gaggctgtgc tgaagacaag     2220

cacagtggcc tggtgcgcct tggaaaccaa caactattca cgagccagta tgaccttcac     2280

atctttagaa attatgaaaa cgtatgtgat tggagggttt ggaaaaccag ttatcttatt     2340

taacatttta aaaattacct aacagttatt tacaaacagg tctgtgcatc ccaggtctgt     2400

cttcttttca aggtctgggc cttgtgctcg ggttatgttt gtgggaaatg cttaataaat     2460

actgataata tgggaagaga tgaaaactga ttctcctcac tttgtttcaa acctttctgg     2520

cagtgggatg attcgaattc acttttaaaa ttaaattagc gtgttttgtt ttg            2573


