                         SEQUENCE LISTING

<110>  Seidel, Ronald D
       Chaparro, Rodolfo J
 
<120>  T-CELL MODULATORY MULTIMERIC POLYPEPTIDES AND METHODS OF USE 
       THEREOF

<130>  CUEB-103WO

<150>  62/338,410
<151>  2016-05-18

<160>  81    

<170>  PatentIn version 3.5

<210>  1
<211>  208
<212>  PRT
<213>  Homo sapiens

<400>  1

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Ile Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  2
<211>  174
<212>  PRT
<213>  Homo sapiens

<400>  2

Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu Val 
1               5                   10                  15      


Ala Gln Asn Val Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp 
            20                  25                  30          


Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu 
        35                  40                  45              


Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe 
    50                  55                  60                  


Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser 
65                  70                  75                  80  


Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala 
                85                  90                  95      


Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala 
            100                 105                 110         


Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala 
        115                 120                 125             


Gly Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg His 
    130                 135                 140                 


Ala Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val 
145                 150                 155                 160 


Thr Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu 
                165                 170                 


<210>  3
<211>  175
<212>  PRT
<213>  Homo sapiens

<400>  3

Asp Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu 
1               5                   10                  15      


Val Ala Gln Asn Val Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser 
            20                  25                  30          


Asp Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys 
        35                  40                  45              


Glu Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val 
    50                  55                  60                  


Phe Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly 
65                  70                  75                  80  


Ser Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly 
                85                  90                  95      


Ala Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu 
            100                 105                 110         


Ala Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser 
        115                 120                 125             


Ala Gly Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg 
    130                 135                 140                 


His Ala Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg 
145                 150                 155                 160 


Val Thr Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu 
                165                 170                 175 


<210>  4
<211>  167
<212>  PRT
<213>  Homo sapiens

<400>  4

Asp Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu 
1               5                   10                  15      


Val Ala Gln Asn Val Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser 
            20                  25                  30          


Asp Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys 
        35                  40                  45              


Glu Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val 
    50                  55                  60                  


Phe Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly 
65                  70                  75                  80  


Ser Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly 
                85                  90                  95      


Ala Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu 
            100                 105                 110         


Ala Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser 
        115                 120                 125             


Ala Gly Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg 
    130                 135                 140                 


His Ala Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg 
145                 150                 155                 160 


Val Thr Pro Glu Ile Pro Ala 
                165         


<210>  5
<211>  208
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence


<220>
<221>  Misc_feature
<222>  (67)..(67)
<223>  Xaa is any amino acid other than Isoleucine

<400>  5

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Xaa Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Ile Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  6
<211>  208
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  6

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ala Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Ile Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  7
<211>  208
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence


<220>
<221>  Misc_feature
<222>  (86)..(86)
<223>  Xaa is any amino acid other than Lysine

<400>  7

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Xaa Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Ile Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  8
<211>  208
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  8

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Ala Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Ile Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  9
<211>  208
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence


<220>
<221>  Misc_feature
<222>  (158)..(158)
<223>  Xaa is any amino acid other than Aspartic acid

<400>  9

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Ile Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Xaa Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  10
<211>  208
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  10

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Ile Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Ala Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  11
<211>  174
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence


<220>
<221>  Misc_feature
<222>  (47)..(47)
<223>  Xaa is any amino acid other than Lysine

<400>  11

Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu Val 
1               5                   10                  15      


Ala Gln Asn Val Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp 
            20                  25                  30          


Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Xaa Glu 
        35                  40                  45              


Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe 
    50                  55                  60                  


Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser 
65                  70                  75                  80  


Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala 
                85                  90                  95      


Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala 
            100                 105                 110         


Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala 
        115                 120                 125             


Gly Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg His 
    130                 135                 140                 


Ala Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val 
145                 150                 155                 160 


Thr Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu 
                165                 170                 


<210>  12
<211>  174
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  12

Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu Val 
1               5                   10                  15      


Ala Gln Asn Val Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp 
            20                  25                  30          


Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Ala Glu 
        35                  40                  45              


Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe 
    50                  55                  60                  


Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser 
65                  70                  75                  80  


Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala 
                85                  90                  95      


Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala 
            100                 105                 110         


Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala 
        115                 120                 125             


Gly Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg His 
    130                 135                 140                 


Ala Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val 
145                 150                 155                 160 


Thr Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu 
                165                 170                 


<210>  13
<211>  175
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence


<220>
<221>  Misc_feature
<222>  (48)..(48)
<223>  Xaa is any amino acid other than Lysine

<400>  13

Asp Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu 
1               5                   10                  15      


Val Ala Gln Asn Val Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser 
            20                  25                  30          


Asp Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Xaa 
        35                  40                  45              


Glu Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val 
    50                  55                  60                  


Phe Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly 
65                  70                  75                  80  


Ser Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly 
                85                  90                  95      


Ala Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu 
            100                 105                 110         


Ala Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser 
        115                 120                 125             


Ala Gly Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg 
    130                 135                 140                 


His Ala Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg 
145                 150                 155                 160 


Val Thr Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu 
                165                 170                 175 


<210>  14
<211>  175
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  14

Asp Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu 
1               5                   10                  15      


Val Ala Gln Asn Val Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser 
            20                  25                  30          


Asp Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Ala 
        35                  40                  45              


Glu Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val 
    50                  55                  60                  


Phe Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly 
65                  70                  75                  80  


Ser Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly 
                85                  90                  95      


Ala Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu 
            100                 105                 110         


Ala Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser 
        115                 120                 125             


Ala Gly Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg 
    130                 135                 140                 


His Ala Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg 
145                 150                 155                 160 


Val Thr Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu 
                165                 170                 175 


<210>  15
<211>  167
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence


<220>
<221>  Misc_feature
<222>  (48)..(48)
<223>  Xaa is any amino acid other than Lysine

<400>  15

Asp Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu 
1               5                   10                  15      


Val Ala Gln Asn Val Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser 
            20                  25                  30          


Asp Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Xaa 
        35                  40                  45              


Glu Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val 
    50                  55                  60                  


Phe Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly 
65                  70                  75                  80  


Ser Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly 
                85                  90                  95      


Ala Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu 
            100                 105                 110         


Ala Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser 
        115                 120                 125             


Ala Gly Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg 
    130                 135                 140                 


His Ala Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg 
145                 150                 155                 160 


Val Thr Pro Glu Ile Pro Ala 
                165         


<210>  16
<211>  167
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  16

Asp Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu 
1               5                   10                  15      


Val Ala Gln Asn Val Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser 
            20                  25                  30          


Asp Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Ala 
        35                  40                  45              


Glu Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val 
    50                  55                  60                  


Phe Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly 
65                  70                  75                  80  


Ser Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly 
                85                  90                  95      


Ala Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu 
            100                 105                 110         


Ala Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser 
        115                 120                 125             


Ala Gly Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg 
    130                 135                 140                 


His Ala Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg 
145                 150                 155                 160 


Val Thr Pro Glu Ile Pro Ala 
                165         


<210>  17
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  17

Tyr Pro Tyr Asp Val Pro Asp Tyr Ala 
1               5                   


<210>  18
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  18

Asp Tyr Lys Asp Asp Asp Asp Lys 
1               5               


<210>  19
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  19

Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu 
1               5                   10  


<210>  20
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  20

His His His His His 
1               5   


<210>  21
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  21

His His His His His His 
1               5       


<210>  22
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  22

Trp Ser His Pro Gln Phe Glu Lys 
1               5               


<210>  23
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  23

Arg Tyr Ile Arg Ser 
1               5   


<210>  24
<211>  4
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  24

Phe His His Thr 
1               


<210>  25
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  25

Trp Glu Ala Ala Ala Arg Glu Ala Cys Cys Arg Glu Cys Cys Ala Arg 
1               5                   10                  15      


Ala 
    


<210>  26
<211>  25
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  26

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            20                  25  


<210>  27
<211>  166
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  27

Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu Val 
1               5                   10                  15      


Ala Gln Asn Val Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp 
            20                  25                  30          


Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Ala Glu 
        35                  40                  45              


Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe 
    50                  55                  60                  


Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser 
65                  70                  75                  80  


Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala 
                85                  90                  95      


Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala 
            100                 105                 110         


Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala 
        115                 120                 125             


Gly Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg His 
    130                 135                 140                 


Ala Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val 
145                 150                 155                 160 


Thr Pro Glu Ile Pro Ala 
                165     


<210>  28
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  28

Leu Glu Val Leu Phe Gln Gly Pro 
1               5               


<210>  29
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  29

Glu Asn Leu Tyr Thr Gln Ser 
1               5           


<210>  30
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  30

Asp Asp Asp Asp Lys 
1               5   


<210>  31
<211>  4
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  31

Leu Val Pro Arg 
1               


<210>  32
<211>  22
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  32

Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val 
1               5                   10                  15      


Glu Glu Asn Pro Gly Pro 
            20          


<210>  33
<211>  21
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  33

Gly Ser Gly Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu 
1               5                   10                  15      


Glu Asn Pro Gly Pro 
            20      


<210>  34
<211>  23
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  34

Gly Ser Gly Gln Cys Thr Asn Tyr Ala Leu Leu Lys Leu Ala Gly Asp 
1               5                   10                  15      


Val Glu Ser Asn Pro Gly Pro 
            20              


<210>  35
<211>  25
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  35

Gly Ser Gly Val Lys Gln Thr Leu Asn Phe Asp Leu Leu Lys Leu Ala 
1               5                   10                  15      


Gly Asp Val Glu Ser Asn Pro Gly Pro 
            20                  25  


<210>  36
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  36

Leu Val Pro Arg Gly Ser 
1               5       


<210>  37
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  37

Ser Ile Ile Asn Phe Glu Lys Leu 
1               5               


<210>  38
<211>  25
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  38

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            20                  25  


<210>  39
<211>  20
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  39

Met Ser Arg Ser Val Ala Leu Ala Val Leu Ala Leu Leu Ser Leu Ser 
1               5                   10                  15      


Gly Leu Glu Ala 
            20  


<210>  40
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  40

Arg Ala His Tyr Asn Ile Val Thr Phe 
1               5                   


<210>  41
<211>  167
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence


<220>
<221>  Misc_feature
<222>  (48)..(48)
<223>  Xaa is selected from amino acid A, D, or E

<220>
<221>  Misc_feature
<222>  (148)..(148)
<223>  Xaa is selected from amino acid A, R, E, or L

<400>  41

Asp Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu 
1               5                   10                  15      


Val Ala Gln Asn Val Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser 
            20                  25                  30          


Asp Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Xaa 
        35                  40                  45              


Glu Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val 
    50                  55                  60                  


Phe Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly 
65                  70                  75                  80  


Ser Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly 
                85                  90                  95      


Ala Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu 
            100                 105                 110         


Ala Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser 
        115                 120                 125             


Ala Gly Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg 
    130                 135                 140                 


His Ala Trp Xaa Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg 
145                 150                 155                 160 


Val Thr Pro Glu Ile Pro Ala 
                165         


<210>  42
<211>  208
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  42

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Ala Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Ile Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  43
<211>  167
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  43

Asp Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu 
1               5                   10                  15      


Val Ala Gln Asn Val Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser 
            20                  25                  30          


Asp Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Ala 
        35                  40                  45              


Glu Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val 
    50                  55                  60                  


Phe Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly 
65                  70                  75                  80  


Ser Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly 
                85                  90                  95      


Ala Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu 
            100                 105                 110         


Ala Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser 
        115                 120                 125             


Ala Gly Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg 
    130                 135                 140                 


His Ala Trp Ala Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg 
145                 150                 155                 160 


Val Thr Pro Glu Ile Pro Ala 
                165         


<210>  44
<211>  167
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  44

Asp Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu 
1               5                   10                  15      


Val Ala Gln Asn Val Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser 
            20                  25                  30          


Asp Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Ala 
        35                  40                  45              


Glu Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val 
    50                  55                  60                  


Phe Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly 
65                  70                  75                  80  


Ser Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly 
                85                  90                  95      


Ala Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu 
            100                 105                 110         


Ala Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser 
        115                 120                 125             


Ala Gly Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg 
    130                 135                 140                 


His Ala Trp Arg Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg 
145                 150                 155                 160 


Val Thr Pro Glu Ile Pro Ala 
                165         


<210>  45
<211>  167
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  45

Asp Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu 
1               5                   10                  15      


Val Ala Gln Asn Val Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser 
            20                  25                  30          


Asp Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Ala 
        35                  40                  45              


Glu Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val 
    50                  55                  60                  


Phe Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly 
65                  70                  75                  80  


Ser Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly 
                85                  90                  95      


Ala Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu 
            100                 105                 110         


Ala Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser 
        115                 120                 125             


Ala Gly Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg 
    130                 135                 140                 


His Ala Trp Glu Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg 
145                 150                 155                 160 


Val Thr Pro Glu Ile Pro Ala 
                165         


<210>  46
<211>  167
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  46

Asp Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu 
1               5                   10                  15      


Val Ala Gln Asn Val Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser 
            20                  25                  30          


Asp Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Ala 
        35                  40                  45              


Glu Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val 
    50                  55                  60                  


Phe Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly 
65                  70                  75                  80  


Ser Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly 
                85                  90                  95      


Ala Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu 
            100                 105                 110         


Ala Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser 
        115                 120                 125             


Ala Gly Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg 
    130                 135                 140                 


His Ala Trp Leu Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg 
145                 150                 155                 160 


Val Thr Pro Glu Ile Pro Ala 
                165         


<210>  47
<211>  254
<212>  PRT
<213>  Homo sapiens

<400>  47

Met Glu Tyr Ala Ser Asp Ala Ser Leu Asp Pro Glu Ala Pro Trp Pro 
1               5                   10                  15      


Pro Ala Pro Arg Ala Arg Ala Cys Arg Val Leu Pro Trp Ala Leu Val 
            20                  25                  30          


Ala Gly Leu Leu Leu Leu Leu Leu Leu Ala Ala Ala Cys Ala Val Phe 
        35                  40                  45              


Leu Ala Cys Pro Trp Ala Val Ser Gly Ala Arg Ala Ser Pro Gly Ser 
    50                  55                  60                  


Ala Ala Ser Pro Arg Leu Arg Glu Gly Pro Glu Leu Ser Pro Asp Asp 
65                  70                  75                  80  


Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu Val 
                85                  90                  95      


Ala Gln Asn Val Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp 
            100                 105                 110         


Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu 
        115                 120                 125             


Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe 
    130                 135                 140                 


Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser 
145                 150                 155                 160 


Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala 
                165                 170                 175     


Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala 
            180                 185                 190         


Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala 
        195                 200                 205             


Gly Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg His 
    210                 215                 220                 


Ala Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val 
225                 230                 235                 240 


Thr Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu 
                245                 250                 


<210>  48
<211>  220
<212>  PRT
<213>  Homo sapiens

<400>  48

Met Leu Arg Leu Leu Leu Ala Leu Asn Leu Phe Pro Ser Ile Gln Val 
1               5                   10                  15      


Thr Gly Asn Lys Ile Leu Val Lys Gln Ser Pro Met Leu Val Ala Tyr 
            20                  25                  30          


Asp Asn Ala Val Asn Leu Ser Cys Lys Tyr Ser Tyr Asn Leu Phe Ser 
        35                  40                  45              


Arg Glu Phe Arg Ala Ser Leu His Lys Gly Leu Asp Ser Ala Val Glu 
    50                  55                  60                  


Val Cys Val Val Tyr Gly Asn Tyr Ser Gln Gln Leu Gln Val Tyr Ser 
65                  70                  75                  80  


Lys Thr Gly Phe Asn Cys Asp Gly Lys Leu Gly Asn Glu Ser Val Thr 
                85                  90                  95      


Phe Tyr Leu Gln Asn Leu Tyr Val Asn Gln Thr Asp Ile Tyr Phe Cys 
            100                 105                 110         


Lys Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser 
        115                 120                 125             


Asn Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro 
    130                 135                 140                 


Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly 
145                 150                 155                 160 


Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile 
                165                 170                 175     


Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met 
            180                 185                 190         


Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro 
        195                 200                 205             


Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
    210                 215                 220 


<210>  49
<211>  123
<212>  PRT
<213>  Homo sapiens

<400>  49

Met Leu Arg Leu Leu Leu Ala Leu Asn Leu Phe Pro Ser Ile Gln Val 
1               5                   10                  15      


Thr Gly Asn Lys Ile Leu Val Lys Gln Ser Pro Met Leu Val Ala Tyr 
            20                  25                  30          


Asp Asn Ala Val Asn Leu Ser Trp Lys His Leu Cys Pro Ser Pro Leu 
        35                  40                  45              


Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly 
    50                  55                  60                  


Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe 
65                  70                  75                  80  


Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn 
                85                  90                  95      


Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr 
            100                 105                 110         


Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
        115                 120             


<210>  50
<211>  101
<212>  PRT
<213>  Homo sapiens

<400>  50

Met Leu Arg Leu Leu Leu Ala Leu Asn Leu Phe Pro Ser Ile Gln Val 
1               5                   10                  15      


Thr Gly Lys His Leu Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys 
            20                  25                  30          


Pro Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser 
        35                  40                  45              


Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg 
    50                  55                  60                  


Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro 
65                  70                  75                  80  


Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe 
                85                  90                  95      


Ala Ala Tyr Arg Ser 
            100     


<210>  51
<211>  255
<212>  PRT
<213>  Homo sapiens

<400>  51

Met Gly Asn Ser Cys Tyr Asn Ile Val Ala Thr Leu Leu Leu Val Leu 
1               5                   10                  15      


Asn Phe Glu Arg Thr Arg Ser Leu Gln Asp Pro Cys Ser Asn Cys Pro 
            20                  25                  30          


Ala Gly Thr Phe Cys Asp Asn Asn Arg Asn Gln Ile Cys Ser Pro Cys 
        35                  40                  45              


Pro Pro Asn Ser Phe Ser Ser Ala Gly Gly Gln Arg Thr Cys Asp Ile 
    50                  55                  60                  


Cys Arg Gln Cys Lys Gly Val Phe Arg Thr Arg Lys Glu Cys Ser Ser 
65                  70                  75                  80  


Thr Ser Asn Ala Glu Cys Asp Cys Thr Pro Gly Phe His Cys Leu Gly 
                85                  90                  95      


Ala Gly Cys Ser Met Cys Glu Gln Asp Cys Lys Gln Gly Gln Glu Leu 
            100                 105                 110         


Thr Lys Lys Gly Cys Lys Asp Cys Cys Phe Gly Thr Phe Asn Asp Gln 
        115                 120                 125             


Lys Arg Gly Ile Cys Arg Pro Trp Thr Asn Cys Ser Leu Asp Gly Lys 
    130                 135                 140                 


Ser Val Leu Val Asn Gly Thr Lys Glu Arg Asp Val Val Cys Gly Pro 
145                 150                 155                 160 


Ser Pro Ala Asp Leu Ser Pro Gly Ala Ser Ser Val Thr Pro Pro Ala 
                165                 170                 175     


Pro Ala Arg Glu Pro Gly His Ser Pro Gln Ile Ile Ser Phe Phe Leu 
            180                 185                 190         


Ala Leu Thr Ser Thr Ala Leu Leu Phe Leu Leu Phe Phe Leu Thr Leu 
        195                 200                 205             


Arg Phe Ser Val Val Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe 
    210                 215                 220                 


Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly 
225                 230                 235                 240 


Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
                245                 250                 255 


<210>  52
<211>  227
<212>  PRT
<213>  Homo sapiens

<400>  52

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys 
225         


<210>  53
<211>  325
<212>  PRT
<213>  Homo sapiens

<400>  53

Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser 
1               5                   10                  15      


Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
            20                  25                  30          


Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
        35                  40                  45              


Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
    50                  55                  60                  


Ser Ser Val Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr Tyr 
65                  70                  75                  80  


Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Thr 
                85                  90                  95      


Val Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro Pro 
            100                 105                 110         


Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
        115                 120                 125             


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
    130                 135                 140                 


Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val 
145                 150                 155                 160 


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser 
                165                 170                 175     


Thr Phe Arg Val Val Ser Val Leu Thr Val Val His Gln Asp Trp Leu 
            180                 185                 190         


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ala 
        195                 200                 205             


Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro 
    210                 215                 220                 


Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln 
225                 230                 235                 240 


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
                245                 250                 255     


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
            260                 265                 270         


Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
        275                 280                 285             


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
    290                 295                 300                 


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
305                 310                 315                 320 


Leu Ser Pro Gly Lys 
                325 


<210>  54
<211>  246
<212>  PRT
<213>  Homo sapiens

<400>  54

His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Leu Lys Thr 
1               5                   10                  15      


Pro Leu Gly Asp Thr Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
            20                  25                  30          


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
        35                  40                  45              


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
    50                  55                  60                  


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
65                  70                  75                  80  


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
                85                  90                  95      


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
            100                 105                 110         


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
        115                 120                 125             


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
    130                 135                 140                 


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 
145                 150                 155                 160 


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
                165                 170                 175     


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
            180                 185                 190         


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
        195                 200                 205             


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
    210                 215                 220                 


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
225                 230                 235                 240 


Ser Leu Ser Pro Gly Lys 
                245     


<210>  55
<211>  383
<212>  PRT
<213>  Homo sapiens

<400>  55

Pro Thr Lys Ala Pro Asp Val Phe Pro Ile Ile Ser Gly Cys Arg His 
1               5                   10                  15      


Pro Lys Asp Asn Ser Pro Val Val Leu Ala Cys Leu Ile Thr Gly Tyr 
            20                  25                  30          


His Pro Thr Ser Val Thr Val Thr Trp Tyr Met Gly Thr Gln Ser Gln 
        35                  40                  45              


Pro Gln Arg Thr Phe Pro Glu Ile Gln Arg Arg Asp Ser Tyr Tyr Met 
    50                  55                  60                  


Thr Ser Ser Gln Leu Ser Thr Pro Leu Gln Gln Trp Arg Gln Gly Glu 
65                  70                  75                  80  


Tyr Lys Cys Val Val Gln His Thr Ala Ser Lys Ser Lys Lys Glu Ile 
                85                  90                  95      


Phe Arg Trp Pro Glu Ser Pro Lys Ala Gln Ala Ser Ser Val Pro Thr 
            100                 105                 110         


Ala Gln Pro Gln Ala Glu Gly Ser Leu Ala Lys Ala Thr Thr Ala Pro 
        115                 120                 125             


Ala Thr Thr Arg Asn Thr Gly Arg Gly Gly Glu Glu Lys Lys Lys Glu 
    130                 135                 140                 


Lys Glu Lys Glu Glu Gln Glu Glu Arg Glu Thr Lys Thr Pro Glu Cys 
145                 150                 155                 160 


Pro Ser His Thr Gln Pro Leu Gly Val Tyr Leu Leu Thr Pro Ala Val 
                165                 170                 175     


Gln Asp Leu Trp Leu Arg Asp Lys Ala Thr Phe Thr Cys Phe Val Val 
            180                 185                 190         


Gly Ser Asp Leu Lys Asp Ala His Leu Thr Trp Glu Val Ala Gly Lys 
        195                 200                 205             


Val Pro Thr Gly Gly Val Glu Glu Gly Leu Leu Glu Arg His Ser Asn 
    210                 215                 220                 


Gly Ser Gln Ser Gln His Ser Arg Leu Thr Leu Pro Arg Ser Leu Trp 
225                 230                 235                 240 


Asn Ala Gly Thr Ser Val Thr Cys Thr Leu Asn His Pro Ser Leu Pro 
                245                 250                 255     


Pro Gln Arg Leu Met Ala Leu Arg Glu Pro Ala Ala Gln Ala Pro Val 
            260                 265                 270         


Lys Leu Ser Leu Asn Leu Leu Ala Ser Ser Asp Pro Pro Glu Ala Ala 
        275                 280                 285             


Ser Trp Leu Leu Cys Glu Val Ser Gly Phe Ser Pro Pro Asn Ile Leu 
    290                 295                 300                 


Leu Met Trp Leu Glu Asp Gln Arg Glu Val Asn Thr Ser Gly Phe Ala 
305                 310                 315                 320 


Pro Ala Arg Pro Pro Pro Gln Pro Arg Ser Thr Thr Phe Trp Ala Trp 
                325                 330                 335     


Ser Val Leu Arg Val Pro Ala Pro Pro Ser Pro Gln Pro Ala Thr Tyr 
            340                 345                 350         


Thr Cys Val Val Ser His Glu Asp Ser Arg Thr Leu Leu Asn Ala Ser 
        355                 360                 365             


Arg Ser Leu Glu Val Ser Tyr Val Thr Asp His Gly Pro Met Lys 
    370                 375                 380             


<210>  56
<211>  276
<212>  PRT
<213>  Homo sapiens

<400>  56

Val Thr Ser Thr Leu Thr Ile Lys Glx Ser Asp Trp Leu Gly Glu Ser 
1               5                   10                  15      


Met Phe Thr Cys Arg Val Asp His Arg Gly Leu Thr Phe Gln Gln Asn 
            20                  25                  30          


Ala Ser Ser Met Cys Val Pro Asp Gln Asp Thr Ala Ile Arg Val Phe 
        35                  40                  45              


Ala Ile Pro Pro Ser Phe Ala Ser Ile Phe Leu Thr Lys Ser Thr Lys 
    50                  55                  60                  


Leu Thr Cys Leu Val Thr Asp Leu Thr Thr Tyr Asx Ser Val Thr Ile 
65                  70                  75                  80  


Ser Trp Thr Arg Glu Glu Asn Gly Ala Val Lys Thr His Thr Asn Ile 
                85                  90                  95      


Ser Glu Ser His Pro Asn Ala Thr Phe Ser Ala Val Gly Glu Ala Ser 
            100                 105                 110         


Ile Cys Glu Asp Asx Asp Trp Ser Gly Glu Arg Phe Thr Cys Thr Val 
        115                 120                 125             


Thr His Thr Asp Leu Pro Ser Pro Leu Lys Gln Thr Ile Ser Arg Pro 
    130                 135                 140                 


Lys Gly Val Ala Leu His Arg Pro Asx Val Tyr Leu Leu Pro Pro Ala 
145                 150                 155                 160 


Arg Glx Glx Leu Asn Leu Arg Glu Ser Ala Thr Ile Thr Cys Leu Val 
                165                 170                 175     


Thr Gly Phe Ser Pro Ala Asp Val Phe Val Glu Trp Met Gln Arg Gly 
            180                 185                 190         


Glu Pro Leu Ser Pro Gln Lys Tyr Val Thr Ser Ala Pro Met Pro Glu 
        195                 200                 205             


Pro Gln Ala Pro Gly Arg Tyr Phe Ala His Ser Ile Leu Thr Val Ser 
    210                 215                 220                 


Glu Glu Glu Trp Asn Thr Gly Gly Thr Tyr Thr Cys Val Val Ala His 
225                 230                 235                 240 


Glu Ala Leu Pro Asn Arg Val Thr Glu Arg Thr Val Asp Lys Ser Thr 
                245                 250                 255     


Gly Lys Pro Thr Leu Tyr Asn Val Ser Leu Val Met Ser Asp Thr Ala 
            260                 265                 270         


Gly Thr Cys Tyr 
        275     


<210>  57
<211>  353
<212>  PRT
<213>  Homo sapiens

<400>  57

Ala Ser Pro Thr Ser Pro Lys Val Phe Pro Leu Ser Leu Cys Ser Thr 
1               5                   10                  15      


Gln Pro Asp Gly Asn Val Val Ile Ala Cys Leu Val Gln Gly Phe Phe 
            20                  25                  30          


Pro Gln Glu Pro Leu Ser Val Thr Trp Ser Glu Ser Gly Gln Gly Val 
        35                  40                  45              


Thr Ala Arg Asn Phe Pro Pro Ser Gln Asp Ala Ser Gly Asp Leu Tyr 
    50                  55                  60                  


Thr Thr Ser Ser Gln Leu Thr Leu Pro Ala Thr Gln Cys Leu Ala Gly 
65                  70                  75                  80  


Lys Ser Val Thr Cys His Val Lys His Tyr Thr Asn Pro Ser Gln Asp 
                85                  90                  95      


Val Thr Val Pro Cys Pro Val Pro Ser Thr Pro Pro Thr Pro Ser Pro 
            100                 105                 110         


Ser Thr Pro Pro Thr Pro Ser Pro Ser Cys Cys His Pro Arg Leu Ser 
        115                 120                 125             


Leu His Arg Pro Ala Leu Glu Asp Leu Leu Leu Gly Ser Glu Ala Asn 
    130                 135                 140                 


Leu Thr Cys Thr Leu Thr Gly Leu Arg Asp Ala Ser Gly Val Thr Phe 
145                 150                 155                 160 


Thr Trp Thr Pro Ser Ser Gly Lys Ser Ala Val Gln Gly Pro Pro Glu 
                165                 170                 175     


Arg Asp Leu Cys Gly Cys Tyr Ser Val Ser Ser Val Leu Pro Gly Cys 
            180                 185                 190         


Ala Glu Pro Trp Asn His Gly Lys Thr Phe Thr Cys Thr Ala Ala Tyr 
        195                 200                 205             


Pro Glu Ser Lys Thr Pro Leu Thr Ala Thr Leu Ser Lys Ser Gly Asn 
    210                 215                 220                 


Thr Phe Arg Pro Glu Val His Leu Leu Pro Pro Pro Ser Glu Glu Leu 
225                 230                 235                 240 


Ala Leu Asn Glu Leu Val Thr Leu Thr Cys Leu Ala Arg Gly Phe Ser 
                245                 250                 255     


Pro Lys Asp Val Leu Val Arg Trp Leu Gln Gly Ser Gln Glu Leu Pro 
            260                 265                 270         


Arg Glu Lys Tyr Leu Thr Trp Ala Ser Arg Gln Glu Pro Ser Gln Gly 
        275                 280                 285             


Thr Thr Thr Phe Ala Val Thr Ser Ile Leu Arg Val Ala Ala Glu Asp 
    290                 295                 300                 


Trp Lys Lys Gly Asp Thr Phe Ser Cys Met Val Gly His Glu Ala Leu 
305                 310                 315                 320 


Pro Leu Ala Phe Thr Gln Lys Thr Ile Asp Arg Leu Ala Gly Lys Pro 
                325                 330                 335     


Thr His Val Asn Val Ser Val Val Met Ala Glu Val Asp Gly Thr Cys 
            340                 345                 350         


Tyr 
    


<210>  58
<211>  222
<212>  PRT
<213>  Homo sapiens

<400>  58

Ala Asp Pro Cys Asp Ser Asn Pro Arg Gly Val Ser Ala Tyr Leu Ser 
1               5                   10                  15      


Arg Pro Ser Pro Phe Asp Leu Phe Ile Arg Lys Ser Pro Thr Ile Thr 
            20                  25                  30          


Cys Leu Val Val Asp Leu Ala Pro Ser Lys Gly Thr Val Asn Leu Thr 
        35                  40                  45              


Trp Ser Arg Ala Ser Gly Lys Pro Val Asn His Ser Thr Arg Lys Glu 
    50                  55                  60                  


Glu Lys Gln Arg Asn Gly Thr Leu Thr Val Thr Ser Thr Leu Pro Val 
65                  70                  75                  80  


Gly Thr Arg Asp Trp Ile Glu Gly Glu Thr Tyr Gln Cys Arg Val Thr 
                85                  90                  95      


His Pro His Leu Pro Arg Ala Leu Met Arg Ser Thr Thr Lys Thr Ser 
            100                 105                 110         


Gly Pro Arg Ala Ala Pro Glu Val Tyr Ala Phe Ala Thr Pro Glu Trp 
        115                 120                 125             


Pro Gly Ser Arg Asp Lys Arg Thr Leu Ala Cys Leu Ile Gln Asn Phe 
    130                 135                 140                 


Met Pro Glu Asp Ile Ser Val Gln Trp Leu His Asn Glu Val Gln Leu 
145                 150                 155                 160 


Pro Asp Ala Arg His Ser Thr Thr Gln Pro Arg Lys Thr Lys Gly Ser 
                165                 170                 175     


Gly Phe Phe Val Phe Ser Arg Leu Glu Val Thr Arg Ala Glu Trp Glu 
            180                 185                 190         


Gln Lys Asp Glu Phe Ile Cys Arg Ala Val His Glu Ala Ala Ser Pro 
        195                 200                 205             


Ser Gln Thr Val Gln Arg Ala Val Ser Val Asn Pro Gly Lys 
    210                 215                 220         


<210>  59
<211>  327
<212>  PRT
<213>  Homo sapiens

<400>  59

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Ser Cys Pro Ala Pro 
            100                 105                 110         


Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
        115                 120                 125             


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
    130                 135                 140                 


Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
145                 150                 155                 160 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
                165                 170                 175     


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
            180                 185                 190         


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
        195                 200                 205             


Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
    210                 215                 220                 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
225                 230                 235                 240 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
                245                 250                 255     


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
            260                 265                 270         


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
        275                 280                 285             


Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
    290                 295                 300                 


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
305                 310                 315                 320 


Leu Ser Leu Ser Leu Gly Lys 
                325         


<210>  60
<211>  365
<212>  PRT
<213>  Homo sapiens

<400>  60

Met Ala Val Met Ala Pro Arg Thr Leu Leu Leu Leu Leu Ser Gly Ala 
1               5                   10                  15      


Leu Ala Leu Thr Gln Thr Trp Ala Gly Ser His Ser Met Arg Tyr Phe 
            20                  25                  30          


Phe Thr Ser Val Ser Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Ala 
        35                  40                  45              


Val Gly Tyr Val Asp Asp Thr Gln Phe Val Arg Phe Asp Ser Asp Ala 
    50                  55                  60                  


Ala Ser Gln Lys Met Glu Pro Arg Ala Pro Trp Ile Glu Gln Glu Gly 
65                  70                  75                  80  


Pro Glu Tyr Trp Asp Gln Glu Thr Arg Asn Met Lys Ala His Ser Gln 
                85                  90                  95      


Thr Asp Arg Ala Asn Leu Gly Thr Leu Arg Gly Tyr Tyr Asn Gln Ser 
            100                 105                 110         


Glu Asp Gly Ser His Thr Ile Gln Ile Met Tyr Gly Cys Asp Val Gly 
        115                 120                 125             


Pro Asp Gly Arg Phe Leu Arg Gly Tyr Arg Gln Asp Ala Tyr Asp Gly 
    130                 135                 140                 


Lys Asp Tyr Ile Ala Leu Asn Glu Asp Leu Arg Ser Trp Thr Ala Ala 
145                 150                 155                 160 


Asp Met Ala Ala Gln Ile Thr Lys Arg Lys Trp Glu Ala Val His Ala 
                165                 170                 175     


Ala Glu Gln Arg Arg Val Tyr Leu Glu Gly Arg Cys Val Asp Gly Leu 
            180                 185                 190         


Arg Arg Tyr Leu Glu Asn Gly Lys Glu Thr Leu Gln Arg Thr Asp Pro 
        195                 200                 205             


Pro Lys Thr His Met Thr His His Pro Ile Ser Asp His Glu Ala Thr 
    210                 215                 220                 


Leu Arg Cys Trp Ala Leu Gly Phe Tyr Pro Ala Glu Ile Thr Leu Thr 
225                 230                 235                 240 


Trp Gln Arg Asp Gly Glu Asp Gln Thr Gln Asp Thr Glu Leu Val Glu 
                245                 250                 255     


Thr Arg Pro Ala Gly Asp Gly Thr Phe Gln Lys Trp Ala Ala Val Val 
            260                 265                 270         


Val Pro Ser Gly Glu Glu Gln Arg Tyr Thr Cys His Val Gln His Glu 
        275                 280                 285             


Gly Leu Pro Lys Pro Leu Thr Leu Arg Trp Glu Leu Ser Ser Gln Pro 
    290                 295                 300                 


Thr Ile Pro Ile Val Gly Ile Ile Ala Gly Leu Val Leu Leu Gly Ala 
305                 310                 315                 320 


Val Ile Thr Gly Ala Val Val Ala Ala Val Met Trp Arg Arg Lys Ser 
                325                 330                 335     


Ser Asp Arg Lys Gly Gly Ser Tyr Thr Gln Ala Ala Ser Ser Asp Ser 
            340                 345                 350         


Ala Gln Gly Ser Asp Val Ser Leu Thr Ala Cys Lys Val 
        355                 360                 365 


<210>  61
<211>  362
<212>  PRT
<213>  Homo sapiens

<400>  61

Met Leu Val Met Ala Pro Arg Thr Val Leu Leu Leu Leu Ser Ala Ala 
1               5                   10                  15      


Leu Ala Leu Thr Glu Thr Trp Ala Gly Ser His Ser Met Arg Tyr Phe 
            20                  25                  30          


Tyr Thr Ser Val Ser Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Ser 
        35                  40                  45              


Val Gly Tyr Val Asp Asp Thr Gln Phe Val Arg Phe Asp Ser Asp Ala 
    50                  55                  60                  


Ala Ser Pro Arg Glu Glu Pro Arg Ala Pro Trp Ile Glu Gln Glu Gly 
65                  70                  75                  80  


Pro Glu Tyr Trp Asp Arg Asn Thr Gln Ile Tyr Lys Ala Gln Ala Gln 
                85                  90                  95      


Thr Asp Arg Glu Ser Leu Arg Asn Leu Arg Gly Tyr Tyr Asn Gln Ser 
            100                 105                 110         


Glu Ala Gly Ser His Thr Leu Gln Ser Met Tyr Gly Cys Asp Val Gly 
        115                 120                 125             


Pro Asp Gly Arg Leu Leu Arg Gly His Asp Gln Tyr Ala Tyr Asp Gly 
    130                 135                 140                 


Lys Asp Tyr Ile Ala Leu Asn Glu Asp Leu Arg Ser Trp Thr Ala Ala 
145                 150                 155                 160 


Asp Thr Ala Ala Gln Ile Thr Gln Arg Lys Trp Glu Ala Ala Arg Glu 
                165                 170                 175     


Ala Glu Gln Arg Arg Ala Tyr Leu Glu Gly Glu Cys Val Glu Trp Leu 
            180                 185                 190         


Arg Arg Tyr Leu Glu Asn Gly Lys Asp Lys Leu Glu Arg Ala Asp Pro 
        195                 200                 205             


Pro Lys Thr His Val Thr His His Pro Ile Ser Asp His Glu Ala Thr 
    210                 215                 220                 


Leu Arg Cys Trp Ala Leu Gly Phe Tyr Pro Ala Glu Ile Thr Leu Thr 
225                 230                 235                 240 


Trp Gln Arg Asp Gly Glu Asp Gln Thr Gln Asp Thr Glu Leu Val Glu 
                245                 250                 255     


Thr Arg Pro Ala Gly Asp Arg Thr Phe Gln Lys Trp Ala Ala Val Val 
            260                 265                 270         


Val Pro Ser Gly Glu Glu Gln Arg Tyr Thr Cys His Val Gln His Glu 
        275                 280                 285             


Gly Leu Pro Lys Pro Leu Thr Leu Arg Trp Glu Pro Ser Ser Gln Ser 
    290                 295                 300                 


Thr Val Pro Ile Val Gly Ile Val Ala Gly Leu Ala Val Leu Ala Val 
305                 310                 315                 320 


Val Val Ile Gly Ala Val Val Ala Ala Val Met Cys Arg Arg Lys Ser 
                325                 330                 335     


Ser Gly Gly Lys Gly Gly Ser Tyr Ser Gln Ala Ala Cys Ser Asp Ser 
            340                 345                 350         


Ala Gln Gly Ser Asp Val Ser Leu Thr Ala 
        355                 360         


<210>  62
<211>  366
<212>  PRT
<213>  Homo sapiens

<400>  62

Met Arg Val Met Ala Pro Arg Ala Leu Leu Leu Leu Leu Ser Gly Gly 
1               5                   10                  15      


Leu Ala Leu Thr Glu Thr Trp Ala Cys Ser His Ser Met Arg Tyr Phe 
            20                  25                  30          


Asp Thr Ala Val Ser Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Ser 
        35                  40                  45              


Val Gly Tyr Val Asp Asp Thr Gln Phe Val Arg Phe Asp Ser Asp Ala 
    50                  55                  60                  


Ala Ser Pro Arg Gly Glu Pro Arg Ala Pro Trp Val Glu Gln Glu Gly 
65                  70                  75                  80  


Pro Glu Tyr Trp Asp Arg Glu Thr Gln Asn Tyr Lys Arg Gln Ala Gln 
                85                  90                  95      


Ala Asp Arg Val Ser Leu Arg Asn Leu Arg Gly Tyr Tyr Asn Gln Ser 
            100                 105                 110         


Glu Asp Gly Ser His Thr Leu Gln Arg Met Tyr Gly Cys Asp Leu Gly 
        115                 120                 125             


Pro Asp Gly Arg Leu Leu Arg Gly Tyr Asp Gln Ser Ala Tyr Asp Gly 
    130                 135                 140                 


Lys Asp Tyr Ile Ala Leu Asn Glu Asp Leu Arg Ser Trp Thr Ala Ala 
145                 150                 155                 160 


Asp Thr Ala Ala Gln Ile Thr Gln Arg Lys Leu Glu Ala Ala Arg Ala 
                165                 170                 175     


Ala Glu Gln Leu Arg Ala Tyr Leu Glu Gly Thr Cys Val Glu Trp Leu 
            180                 185                 190         


Arg Arg Tyr Leu Glu Asn Gly Lys Glu Thr Leu Gln Arg Ala Glu Pro 
        195                 200                 205             


Pro Lys Thr His Val Thr His His Pro Leu Ser Asp His Glu Ala Thr 
    210                 215                 220                 


Leu Arg Cys Trp Ala Leu Gly Phe Tyr Pro Ala Glu Ile Thr Leu Thr 
225                 230                 235                 240 


Trp Gln Arg Asp Gly Glu Asp Gln Thr Gln Asp Thr Glu Leu Val Glu 
                245                 250                 255     


Thr Arg Pro Ala Gly Asp Gly Thr Phe Gln Lys Trp Ala Ala Val Val 
            260                 265                 270         


Val Pro Ser Gly Gln Glu Gln Arg Tyr Thr Cys His Met Gln His Glu 
        275                 280                 285             


Gly Leu Gln Glu Pro Leu Thr Leu Ser Trp Glu Pro Ser Ser Gln Pro 
    290                 295                 300                 


Thr Ile Pro Ile Met Gly Ile Val Ala Gly Leu Ala Val Leu Val Val 
305                 310                 315                 320 


Leu Ala Val Leu Gly Ala Val Val Thr Ala Met Met Cys Arg Arg Lys 
                325                 330                 335     


Ser Ser Gly Gly Lys Gly Gly Ser Cys Ser Gln Ala Ala Cys Ser Asn 
            340                 345                 350         


Ser Ala Gln Gly Ser Asp Glu Ser Leu Ile Thr Cys Lys Ala 
        355                 360                 365     


<210>  63
<211>  119
<212>  PRT
<213>  Homo sapiens

<400>  63

Met Ser Arg Ser Val Ala Leu Ala Val Leu Ala Leu Leu Ser Leu Ser 
1               5                   10                  15      


Gly Leu Glu Ala Ile Gln Arg Thr Pro Lys Ile Gln Val Tyr Ser Arg 
            20                  25                  30          


His Pro Ala Glu Asn Gly Lys Ser Asn Phe Leu Asn Cys Tyr Val Ser 
        35                  40                  45              


Gly Phe His Pro Ser Asp Ile Glu Val Asp Leu Leu Lys Asn Gly Glu 
    50                  55                  60                  


Arg Ile Glu Lys Val Glu His Ser Asp Leu Ser Phe Ser Lys Asp Trp 
65                  70                  75                  80  


Ser Phe Tyr Leu Leu Tyr Tyr Thr Glu Phe Thr Pro Thr Glu Lys Asp 
                85                  90                  95      


Glu Tyr Ala Cys Arg Val Asn His Val Thr Leu Ser Gln Pro Lys Ile 
            100                 105                 110         


Val Lys Trp Asp Arg Asp Met 
        115                 


<210>  64
<211>  119
<212>  PRT
<213>  Pan troglodytes

<400>  64

Met Ser Arg Ser Val Ala Leu Ala Val Leu Ala Leu Leu Ser Leu Ser 
1               5                   10                  15      


Gly Leu Glu Ala Ile Gln Arg Thr Pro Lys Ile Gln Val Tyr Ser Arg 
            20                  25                  30          


His Pro Ala Glu Asn Gly Lys Ser Asn Phe Leu Asn Cys Tyr Val Ser 
        35                  40                  45              


Gly Phe His Pro Ser Asp Ile Glu Val Asp Leu Leu Lys Asn Gly Glu 
    50                  55                  60                  


Arg Ile Glu Lys Val Glu His Ser Asp Leu Ser Phe Ser Lys Asp Trp 
65                  70                  75                  80  


Ser Phe Tyr Leu Leu Tyr Tyr Thr Glu Phe Thr Pro Thr Glu Lys Asp 
                85                  90                  95      


Glu Tyr Ala Cys Arg Val Asn His Val Thr Leu Ser Gln Pro Lys Ile 
            100                 105                 110         


Val Lys Trp Asp Arg Asp Met 
        115                 


<210>  65
<211>  119
<212>  PRT
<213>  Macaca mulatta

<400>  65

Met Ser Arg Ser Val Ala Leu Ala Val Leu Ala Leu Leu Ser Leu Ser 
1               5                   10                  15      


Gly Leu Glu Ala Ile Gln Arg Thr Pro Lys Ile Gln Val Tyr Ser Arg 
            20                  25                  30          


His Pro Pro Glu Asn Gly Lys Pro Asn Phe Leu Asn Cys Tyr Val Ser 
        35                  40                  45              


Gly Phe His Pro Ser Asp Ile Glu Val Asp Leu Leu Lys Asn Gly Glu 
    50                  55                  60                  


Lys Met Gly Lys Val Glu His Ser Asp Leu Ser Phe Ser Lys Asp Trp 
65                  70                  75                  80  


Ser Phe Tyr Leu Leu Tyr Tyr Thr Glu Phe Thr Pro Asn Glu Lys Asp 
                85                  90                  95      


Glu Tyr Ala Cys Arg Val Asn His Val Thr Leu Ser Gly Pro Arg Thr 
            100                 105                 110         


Val Lys Trp Asp Arg Asp Met 
        115                 


<210>  66
<211>  118
<212>  PRT
<213>  Bos Taurus

<400>  66

Met Ala Arg Phe Val Ala Leu Val Leu Leu Gly Leu Leu Ser Leu Ser 
1               5                   10                  15      


Gly Leu Asp Ala Ile Gln Arg Pro Pro Lys Ile Gln Val Tyr Ser Arg 
            20                  25                  30          


His Pro Pro Glu Asp Gly Lys Pro Asn Tyr Leu Asn Cys Tyr Val Tyr 
        35                  40                  45              


Gly Phe His Pro Pro Gln Ile Glu Ile Asp Leu Leu Lys Asn Gly Glu 
    50                  55                  60                  


Lys Ile Lys Ser Glu Gln Ser Asp Leu Ser Phe Ser Lys Asp Trp Ser 
65                  70                  75                  80  


Phe Tyr Leu Leu Ser His Ala Glu Phe Thr Pro Asn Ser Lys Asp Gln 
                85                  90                  95      


Tyr Ser Cys Arg Val Lys His Val Thr Leu Glu Gln Pro Arg Ile Val 
            100                 105                 110         


Lys Trp Asp Arg Asp Leu 
        115             


<210>  67
<211>  119
<212>  PRT
<213>  Mus musculus

<400>  67

Met Ala Arg Ser Val Thr Leu Val Phe Leu Val Leu Val Ser Leu Thr 
1               5                   10                  15      


Gly Leu Tyr Ala Ile Gln Lys Thr Pro Gln Ile Gln Val Tyr Ser Arg 
            20                  25                  30          


His Pro Pro Glu Asn Gly Lys Pro Asn Ile Leu Asn Cys Tyr Val Thr 
        35                  40                  45              


Gln Phe His Pro Pro His Ile Glu Ile Gln Met Leu Lys Asn Gly Lys 
    50                  55                  60                  


Lys Ile Pro Lys Val Glu Met Ser Asp Met Ser Phe Ser Lys Asp Trp 
65                  70                  75                  80  


Ser Phe Tyr Ile Leu Ala His Thr Glu Phe Thr Pro Thr Glu Thr Asp 
                85                  90                  95      


Thr Tyr Ala Cys Arg Val Lys His Ala Ser Met Ala Glu Pro Lys Thr 
            100                 105                 110         


Val Tyr Trp Asp Arg Asp Met 
        115                 


<210>  68
<211>  2316
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  68
atgtctcgct ccgtggcctt agctgtgctc gcgctactct ctctttctgg cctggaggcc       60

gttatccacg tgaccaagga agtgaaagaa gtggcaacgc tgtcctgtgg tcacaatgtt      120

tctgttgaag agctggcaca aactcgcatc tactggcaaa aggagaagaa aatggtgctg      180

actatgatgt ctggggacat gaatatatgg cccgagtaca agaaccggac catctttgat      240

atcactaata acctctccat tgtgatcctg gctctgcgcc catctgacga gggcacatac      300

gagtgtgttg ttctgaagta tgaaaaagac gctttcaagc gggaacacct ggctgaagtg      360

acgttatcag tcaaagctga cttccctaca cctagtatat ctgactttga aattccaact      420

tctaatatta gaaggataat ttgctcaacc tctggaggtt ttccagagcc tcacctctcc      480

tggttggaaa atggagaaga attaaatgcc atcaacacaa cagtttccca agatcctgaa      540

actgagctct atgctgttag cagcaaactg gatttcaata tgacaaccaa ccacagcttc      600

atgtgtctca tcaagtatgg acatttaaga gtgaatcaga ccttcaactg gaatacaacc      660

aagcaagagc attttcctga taacggaggc ggaggatctg gtggtggagg ttctggtggt      720

gggggatctg gaggcggagg atctggcccg cattccctgc gctactttgt gaccgctgtt      780

agccgcccgg gcctgggtga accgcgttac atggaggtcg gttatgtgga tgacacggag      840

tttgtgcgtt tcgattcaga cgctgagaac ccgcgttacg aaccgcgtgc aagatggatg      900

gaacaggaag gcccggaata ttgggaaaga gagacccaaa aggcaaaagg caacgaacaa      960

agcttccgtg tggacctgcg taccctgctg ggcgcctaca accaatcaaa aggtggctcg     1020

cacacgatcc aggtgatcag cggctgcgag gttggtagcg atggccgtct gctgcgcggc     1080

tatcagcaat acgcctacga cggttgcgat tatatcgcac tgaatgaaga cctgaaaacc     1140

tggacggcgg ccgatatggc agctctgatt acgaagcaca aatgggaaca ggctggcgag     1200

gcggaaagac tgcgcgccta cctggagggt acctgcgtgg aatggctgcg tcgctatctg     1260

aagaacggca atgccacctt gctgcgtacg gatagcccga aagcacatgt tacccaccac     1320

agccgccccg aggacaaggt tacgctgcgt tgttgggctc tgggctttta tccggcggat     1380

attaccctga cgtggcagct gaacggtgaa gagctgatcc aagatatgga actggtggaa     1440

acccgtccgt gcggcgatgg cacgttccag aaatgggcaa gcgtggttgt cccgctgggt     1500

aaagaacaat actacacctg tcatgtttac caccagggtc tgccggaacc gctgacgctg     1560

cgttgggcag ctgcgggtgg ccccagaggg cccacaatca agccctgtcc tccatgcaaa     1620

tgcccagcac ctaacctctt gggtggacca tccgtcttca tcttccctcc aaagatcaag     1680

gatgtactca tgatctccct gagccccata gtcacatgtg tggtggtgga tgtgagcgag     1740

gatgacccag atgtccagat cagctggttt gtgaacaacg tggaagtaca cacagctcag     1800

acacaaaccc atagagagga ttacaacagt actctccggg tggtcagtgc cctccccatc     1860

cagcaccagg actggatgag tggcaaggag ttcaaatgca aggtcaacaa caaagacctc     1920

ccagcgccca tcgagagaac catctcaaaa cccaaagggt cagtaagagc tccacaggta     1980

tatgtcttgc ctccaccaga agaagagatg actaagaaac aggtcactct gacctgcatg     2040

gtcacagact tcatgcctga agacatttac gtggagtgga ccaacaacgg gaaaacagag     2100

ctaaactaca agaacactga accagtcctg gactctgatg gttcttactt catgtacagc     2160

aagctgagag tggaaaagaa gaactgggtg gaaagaaata gctactcctg ttcagtggtc     2220

cacgagggtc tgcacaatca ccacacgact aagagcttct cccggactcc gggtaaaggc     2280

ggatcacatc accatcacca tcaccatcac tagtga                               2316


<210>  69
<211>  770
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  69

Met Ser Arg Ser Val Ala Leu Ala Val Leu Ala Leu Leu Ser Leu Ser 
1               5                   10                  15      


Gly Leu Glu Ala Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala 
            20                  25                  30          


Thr Leu Ser Cys Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr 
        35                  40                  45              


Arg Ile Tyr Trp Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser 
    50                  55                  60                  


Gly Asp Met Asn Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp 
65                  70                  75                  80  


Ile Thr Asn Asn Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp 
                85                  90                  95      


Glu Gly Thr Tyr Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe 
            100                 105                 110         


Lys Arg Glu His Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe 
        115                 120                 125             


Pro Thr Pro Ser Ile Ser Asp Phe Glu Ile Pro Thr Ser Asn Ile Arg 
    130                 135                 140                 


Arg Ile Ile Cys Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser 
145                 150                 155                 160 


Trp Leu Glu Asn Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser 
                165                 170                 175     


Gln Asp Pro Glu Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe 
            180                 185                 190         


Asn Met Thr Thr Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His 
        195                 200                 205             


Leu Arg Val Asn Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His 
    210                 215                 220                 


Phe Pro Asp Asn Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
225                 230                 235                 240 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Pro His Ser Leu Arg Tyr Phe 
                245                 250                 255     


Val Thr Ala Val Ser Arg Pro Gly Leu Gly Glu Pro Arg Tyr Met Glu 
            260                 265                 270         


Val Gly Tyr Val Asp Asp Thr Glu Phe Val Arg Phe Asp Ser Asp Ala 
        275                 280                 285             


Glu Asn Pro Arg Tyr Glu Pro Arg Ala Arg Trp Met Glu Gln Glu Gly 
    290                 295                 300                 


Pro Glu Tyr Trp Glu Arg Glu Thr Gln Lys Ala Lys Gly Asn Glu Gln 
305                 310                 315                 320 


Ser Phe Arg Val Asp Leu Arg Thr Leu Leu Gly Ala Tyr Asn Gln Ser 
                325                 330                 335     


Lys Gly Gly Ser His Thr Ile Gln Val Ile Ser Gly Cys Glu Val Gly 
            340                 345                 350         


Ser Asp Gly Arg Leu Leu Arg Gly Tyr Gln Gln Tyr Ala Tyr Asp Gly 
        355                 360                 365             


Cys Asp Tyr Ile Ala Leu Asn Glu Asp Leu Lys Thr Trp Thr Ala Ala 
    370                 375                 380                 


Asp Met Ala Ala Leu Ile Thr Lys His Lys Trp Glu Gln Ala Gly Glu 
385                 390                 395                 400 


Ala Glu Arg Leu Arg Ala Tyr Leu Glu Gly Thr Cys Val Glu Trp Leu 
                405                 410                 415     


Arg Arg Tyr Leu Lys Asn Gly Asn Ala Thr Leu Leu Arg Thr Asp Ser 
            420                 425                 430         


Pro Lys Ala His Val Thr His His Ser Arg Pro Glu Asp Lys Val Thr 
        435                 440                 445             


Leu Arg Cys Trp Ala Leu Gly Phe Tyr Pro Ala Asp Ile Thr Leu Thr 
    450                 455                 460                 


Trp Gln Leu Asn Gly Glu Glu Leu Ile Gln Asp Met Glu Leu Val Glu 
465                 470                 475                 480 


Thr Arg Pro Cys Gly Asp Gly Thr Phe Gln Lys Trp Ala Ser Val Val 
                485                 490                 495     


Val Pro Leu Gly Lys Glu Gln Tyr Tyr Thr Cys His Val Tyr His Gln 
            500                 505                 510         


Gly Leu Pro Glu Pro Leu Thr Leu Arg Trp Ala Ala Ala Gly Gly Pro 
        515                 520                 525             


Arg Gly Pro Thr Ile Lys Pro Cys Pro Pro Cys Lys Cys Pro Ala Pro 
    530                 535                 540                 


Asn Leu Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Ile Lys 
545                 550                 555                 560 


Asp Val Leu Met Ile Ser Leu Ser Pro Ile Val Thr Cys Val Val Val 
                565                 570                 575     


Asp Val Ser Glu Asp Asp Pro Asp Val Gln Ile Ser Trp Phe Val Asn 
            580                 585                 590         


Asn Val Glu Val His Thr Ala Gln Thr Gln Thr His Arg Glu Asp Tyr 
        595                 600                 605             


Asn Ser Thr Leu Arg Val Val Ser Ala Leu Pro Ile Gln His Gln Asp 
    610                 615                 620                 


Trp Met Ser Gly Lys Glu Phe Lys Cys Lys Val Asn Asn Lys Asp Leu 
625                 630                 635                 640 


Pro Ala Pro Ile Glu Arg Thr Ile Ser Lys Pro Lys Gly Ser Val Arg 
                645                 650                 655     


Ala Pro Gln Val Tyr Val Leu Pro Pro Pro Glu Glu Glu Met Thr Lys 
            660                 665                 670         


Lys Gln Val Thr Leu Thr Cys Met Val Thr Asp Phe Met Pro Glu Asp 
        675                 680                 685             


Ile Tyr Val Glu Trp Thr Asn Asn Gly Lys Thr Glu Leu Asn Tyr Lys 
    690                 695                 700                 


Asn Thr Glu Pro Val Leu Asp Ser Asp Gly Ser Tyr Phe Met Tyr Ser 
705                 710                 715                 720 


Lys Leu Arg Val Glu Lys Lys Asn Trp Val Glu Arg Asn Ser Tyr Ser 
                725                 730                 735     


Cys Ser Val Val His Glu Gly Leu His Asn His His Thr Thr Lys Ser 
            740                 745                 750         


Phe Ser Arg Thr Pro Gly Lys Gly Gly Ser His His His His His His 
        755                 760                 765             


His His 
    770 


<210>  70
<211>  2166
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  70
atgtcccgct ccgtggcgct tgcggtgctg gccctgctgt cgttgtccgg gctggaagcg       60

tccattatca acttcgagaa actgggggga ggagcctcag gaggaggagg atccgggggt      120

ggaggtagca tgattcaaaa gacccctcaa atccaggtct actcgtgcca cccacccgag      180

aacggaaagc ctaatatcct gaactgttac gtgacccaat tccacccgcc gcatatcgag      240

atccagatgc tcaagaacgg caagaagatc cccaaggtgg aaatgtccga catgagcttt      300

tccaaggatt ggtcgttcta tatcctggct cataccgagt tcacccccac cgaaaccgat      360

acttacgcct gccgcgtcaa gcacgcctca atggcggagc ctaagaccgt gtactgggac      420

cgggacatgg gtggcggggg gtccggagga ggtggatccg gcggaggggg atctggcgga      480

ggcggatcag gaggtggcgg ctctgaccct gcaggcctgc tggatctgcg gcagggcatg      540

ttcgcacaac tcgtggccca gaacgtgctg ctgatcgatg gaccgctgtc ctggtactcc      600

gacccgggac ttgccggagt gtcactgact ggaggattgt cctacaagga agatacgaag      660

gagctcgtcg tggcgaaggc cggagtgtac tatgtgttct tccagctcga actccggaga      720

gtcgtggccg gggaaggctc cggctccgtg tcacttgccc tgcacctcca gccacttcgg      780

tcggccgctg gagccgccgc actggccctg accgtcgacc tccctcctgc gtcctccgag      840

gctcgcaact cggccttcgg attccaaggg cgccttctgc acctgtccgc gggacagagg      900

ctgggggtgc atctgcatac tgaagcgcgg gcacggcatg cttggcagct gactcaggga      960

gcaactgtcc tgggtctgtt ccgcgtgact ccggaaatcc ccgccggtgg aggtggctca     1020

ggaggcggcg gcagcggtgg aggagggagc ggaggaggcg gatccggtgg aggcggaagc     1080

gaccctgccg gactcctgga tctgcggcag ggcatgttcg cccagttggt ggcgcagaac     1140

gtcctgctca ttgacgggcc gctgtcgtgg tacagcgatc cgggcttggc cggagtctcg     1200

ctgaccggag gactcagcta caaggaagat accaaggagc tggtcgtggc caaggccgga     1260

gtgtactacg tgttcttcca actggaactg cgccgggtgg tggctggcga aggatccggg     1320

tcggtgtccc tggccctgca tctgcagcct ctgcgctcag ccgcaggagc agccgccttg     1380

gcgctcaccg tggaccttcc gcccgcctcc tcggaagccc ggaacagcgc cttcggcttc     1440

caaggcagac tcctgcactt gagcgcgggc cagagactgg gagtgcacct ccacaccgaa     1500

gcgcgcgcaa ggcacgcctg gcagctcacc cagggagcca ccgtgctggg cttgtttcga     1560

gtcacccccg agatcccagc cggcggagga ggttccggtg gcggtggatc aggcggtgga     1620

ggctcgggtg gagggggtag cggagggggt ggttccgacc ccgcaggact gctggacctc     1680

cggcagggga tgttcgcgca actggtggct cagaatgtcc tgctgattga cggccccctg     1740

tcgtggtact cggaccctgg ccttgccggc gtgtccttga ctggagggct gtcgtacaag     1800

gaggacacta aggagctggt cgtggccaaa gccggcgtgt actacgtgtt ctttcagctg     1860

gaactgagga gagtggtggc gggagaaggc agcggctcag tgtccctcgc cctgcacctt     1920

caaccactcc gctctgccgc tggtgcagct gcgctcgccc tcactgtgga tcttccaccg     1980

gcaagctccg aggccagaaa ctccgccttc gggttccagg ggaggctgct gcatctctcc     2040

gccggccaga gactgggcgt gcacttgcac actgaggcta gggctcgcca tgcctggcag     2100

ctgacccagg gcgccactgt gctgggactg ttccgggtga ccccagaaat cccggcctcc     2160

tgatag                                                                2166


<210>  71
<211>  720
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  71

Met Ser Arg Ser Val Ala Leu Ala Val Leu Ala Leu Leu Ser Leu Ser 
1               5                   10                  15      


Gly Leu Glu Ala Ser Ile Ile Asn Phe Glu Lys Leu Gly Gly Gly Ala 
            20                  25                  30          


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Met Ile Gln Lys Thr 
        35                  40                  45              


Pro Gln Ile Gln Val Tyr Ser Cys His Pro Pro Glu Asn Gly Lys Pro 
    50                  55                  60                  


Asn Ile Leu Asn Cys Tyr Val Thr Gln Phe His Pro Pro His Ile Glu 
65                  70                  75                  80  


Ile Gln Met Leu Lys Asn Gly Lys Lys Ile Pro Lys Val Glu Met Ser 
                85                  90                  95      


Asp Met Ser Phe Ser Lys Asp Trp Ser Phe Tyr Ile Leu Ala His Thr 
            100                 105                 110         


Glu Phe Thr Pro Thr Glu Thr Asp Thr Tyr Ala Cys Arg Val Lys His 
        115                 120                 125             


Ala Ser Met Ala Glu Pro Lys Thr Val Tyr Trp Asp Arg Asp Met Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
145                 150                 155                 160 


Gly Gly Ser Gly Gly Gly Gly Ser Asp Pro Ala Gly Leu Leu Asp Leu 
                165                 170                 175     


Arg Gln Gly Met Phe Ala Gln Leu Val Ala Gln Asn Val Leu Leu Ile 
            180                 185                 190         


Asp Gly Pro Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala Gly Val Ser 
        195                 200                 205             


Leu Thr Gly Gly Leu Ser Tyr Lys Glu Asp Thr Lys Glu Leu Val Val 
    210                 215                 220                 


Ala Lys Ala Gly Val Tyr Tyr Val Phe Phe Gln Leu Glu Leu Arg Arg 
225                 230                 235                 240 


Val Val Ala Gly Glu Gly Ser Gly Ser Val Ser Leu Ala Leu His Leu 
                245                 250                 255     


Gln Pro Leu Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala Leu Thr Val 
            260                 265                 270         


Asp Leu Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala Phe Gly Phe 
        275                 280                 285             


Gln Gly Arg Leu Leu His Leu Ser Ala Gly Gln Arg Leu Gly Val His 
    290                 295                 300                 


Leu His Thr Glu Ala Arg Ala Arg His Ala Trp Gln Leu Thr Gln Gly 
305                 310                 315                 320 


Ala Thr Val Leu Gly Leu Phe Arg Val Thr Pro Glu Ile Pro Ala Gly 
                325                 330                 335     


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            340                 345                 350         


Gly Gly Ser Gly Gly Gly Gly Ser Asp Pro Ala Gly Leu Leu Asp Leu 
        355                 360                 365             


Arg Gln Gly Met Phe Ala Gln Leu Val Ala Gln Asn Val Leu Leu Ile 
    370                 375                 380                 


Asp Gly Pro Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala Gly Val Ser 
385                 390                 395                 400 


Leu Thr Gly Gly Leu Ser Tyr Lys Glu Asp Thr Lys Glu Leu Val Val 
                405                 410                 415     


Ala Lys Ala Gly Val Tyr Tyr Val Phe Phe Gln Leu Glu Leu Arg Arg 
            420                 425                 430         


Val Val Ala Gly Glu Gly Ser Gly Ser Val Ser Leu Ala Leu His Leu 
        435                 440                 445             


Gln Pro Leu Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala Leu Thr Val 
    450                 455                 460                 


Asp Leu Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala Phe Gly Phe 
465                 470                 475                 480 


Gln Gly Arg Leu Leu His Leu Ser Ala Gly Gln Arg Leu Gly Val His 
                485                 490                 495     


Leu His Thr Glu Ala Arg Ala Arg His Ala Trp Gln Leu Thr Gln Gly 
            500                 505                 510         


Ala Thr Val Leu Gly Leu Phe Arg Val Thr Pro Glu Ile Pro Ala Gly 
        515                 520                 525             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    530                 535                 540                 


Gly Gly Ser Gly Gly Gly Gly Ser Asp Pro Ala Gly Leu Leu Asp Leu 
545                 550                 555                 560 


Arg Gln Gly Met Phe Ala Gln Leu Val Ala Gln Asn Val Leu Leu Ile 
                565                 570                 575     


Asp Gly Pro Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala Gly Val Ser 
            580                 585                 590         


Leu Thr Gly Gly Leu Ser Tyr Lys Glu Asp Thr Lys Glu Leu Val Val 
        595                 600                 605             


Ala Lys Ala Gly Val Tyr Tyr Val Phe Phe Gln Leu Glu Leu Arg Arg 
    610                 615                 620                 


Val Val Ala Gly Glu Gly Ser Gly Ser Val Ser Leu Ala Leu His Leu 
625                 630                 635                 640 


Gln Pro Leu Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala Leu Thr Val 
                645                 650                 655     


Asp Leu Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala Phe Gly Phe 
            660                 665                 670         


Gln Gly Arg Leu Leu His Leu Ser Ala Gly Gln Arg Leu Gly Val His 
        675                 680                 685             


Leu His Thr Glu Ala Arg Ala Arg His Ala Trp Gln Leu Thr Gln Gly 
    690                 695                 700                 


Ala Thr Val Leu Gly Leu Phe Arg Val Thr Pro Glu Ile Pro Ala Ser 
705                 710                 715                 720 


<210>  72
<211>  2256
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  72
atgtcccgct ccgtggcgct tgcggtgctg gccctgctgt cgttgtccgg gctggaagcg       60

tccattatca acttcgagaa actgggggga ggagcctcag gaggaggagg atccgggggt      120

ggaggtagca tgattcaaaa gacccctcaa atccaggtct actcgtgcca cccacccgag      180

aacggaaagc ctaatatcct gaactgttac gtgacccaat tccacccgcc gcatatcgag      240

atccagatgc tcaagaacgg caagaagatc cccaaggtgg aaatgtccga catgagcttt      300

tccaaggatt ggtcgttcta tatcctggct cataccgagt tcacccccac cgaaaccgat      360

acttacgcct gccgcgtcaa gcacgcctca atggcggagc ctaagaccgt gtactgggac      420

cgggacatgg gtggcggggg gtccggagga ggtggatccg gcggaggggg atctggcgga      480

ggcggatcag gaggtggcgg ctctgcctgc ccctgggccg tgtccggggc tcgcgcctcg      540

cccggctccg cggccagccc gagactccgc gagggtcccg agctttcgcc cgacgaccct      600

gcaggcctgc tggatctgcg gcagggcatg ttcgcacaac tcgtggccca gaacgtgctg      660

ctgatcgatg gaccgctgtc ctggtactcc gacccgggac ttgccggagt gtcactgact      720

ggaggattgt cctacaagga agatacgaag gagctcgtcg tggcgaaggc cggagtgtac      780

tatgtgttct tccagctcga actccggaga gtcgtggccg gggaaggctc cggctccgtg      840

tcacttgccc tgcacctcca gccacttcgg tcggccgctg gagccgccgc actggccctg      900

accgtcgacc tccctcctgc gtcctccgag gctcgcaact cggccttcgg attccaaggg      960

cgccttctgc acctgtccgc gggacagagg ctgggggtgc atctgcatac tgaagcgcgg     1020

gcacggcatg cttggcagct gactcaggga gcaactgtcc tgggtctgtt ccgcgtgact     1080

ccggaaatcc ccgccggtgg aggtggctca ggaggcggcg gcagcggtgg aggagggagc     1140

ggaggaggcg gatccggtgg aggcggaagc gaccctgccg gactcctgga tctgcggcag     1200

ggcatgttcg cccagttggt ggcgcagaac gtcctgctca ttgacgggcc gctgtcgtgg     1260

tacagcgatc cgggcttggc cggagtctcg ctgaccggag gactcagcta caaggaagat     1320

accaaggagc tggtcgtggc caaggccgga gtgtactacg tgttcttcca actggaactg     1380

cgccgggtgg tggctggcga aggatccggg tcggtgtccc tggccctgca tctgcagcct     1440

ctgcgctcag ccgcaggagc agccgccttg gcgctcaccg tggaccttcc gcccgcctcc     1500

tcggaagccc ggaacagcgc cttcggcttc caaggcagac tcctgcactt gagcgcgggc     1560

cagagactgg gagtgcacct ccacaccgaa gcgcgcgcaa ggcacgcctg gcagctcacc     1620

cagggagcca ccgtgctggg cttgtttcga gtcacccccg agatcccagc cggcggagga     1680

ggttccggtg gcggtggatc aggcggtgga ggctcgggtg gagggggtag cggagggggt     1740

ggttccgacc ccgcaggact gctggacctc cggcagggga tgttcgcgca actggtggct     1800

cagaatgtcc tgctgattga cggccccctg tcgtggtact cggaccctgg ccttgccggc     1860

gtgtccttga ctggagggct gtcgtacaag gaggacacta aggagctggt cgtggccaaa     1920

gccggcgtgt actacgtgtt ctttcagctg gaactgagga gagtggtggc gggagaaggc     1980

agcggctcag tgtccctcgc cctgcacctt caaccactcc gctctgccgc tggtgcagct     2040

gcgctcgccc tcactgtgga tcttccaccg gcaagctccg aggccagaaa ctccgccttc     2100

gggttccagg ggaggctgct gcatctctcc gccggccaga gactgggcgt gcacttgcac     2160

actgaggcta gggctcgcca tgcctggcag ctgacccagg gcgccactgt gctgggactg     2220

ttccgggtga ccccagaaat cccggcctcc tgatag                               2256


<210>  73
<211>  750
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  73

Met Ser Arg Ser Val Ala Leu Ala Val Leu Ala Leu Leu Ser Leu Ser 
1               5                   10                  15      


Gly Leu Glu Ala Ser Ile Ile Asn Phe Glu Lys Leu Gly Gly Gly Ala 
            20                  25                  30          


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Met Ile Gln Lys Thr 
        35                  40                  45              


Pro Gln Ile Gln Val Tyr Ser Cys His Pro Pro Glu Asn Gly Lys Pro 
    50                  55                  60                  


Asn Ile Leu Asn Cys Tyr Val Thr Gln Phe His Pro Pro His Ile Glu 
65                  70                  75                  80  


Ile Gln Met Leu Lys Asn Gly Lys Lys Ile Pro Lys Val Glu Met Ser 
                85                  90                  95      


Asp Met Ser Phe Ser Lys Asp Trp Ser Phe Tyr Ile Leu Ala His Thr 
            100                 105                 110         


Glu Phe Thr Pro Thr Glu Thr Asp Thr Tyr Ala Cys Arg Val Lys His 
        115                 120                 125             


Ala Ser Met Ala Glu Pro Lys Thr Val Tyr Trp Asp Arg Asp Met Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
145                 150                 155                 160 


Gly Gly Ser Gly Gly Gly Gly Ser Ala Cys Pro Trp Ala Val Ser Gly 
                165                 170                 175     


Ala Arg Ala Ser Pro Gly Ser Ala Ala Ser Pro Arg Leu Arg Glu Gly 
            180                 185                 190         


Pro Glu Leu Ser Pro Asp Asp Pro Ala Gly Leu Leu Asp Leu Arg Gln 
        195                 200                 205             


Gly Met Phe Ala Gln Leu Val Ala Gln Asn Val Leu Leu Ile Asp Gly 
    210                 215                 220                 


Pro Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala Gly Val Ser Leu Thr 
225                 230                 235                 240 


Gly Gly Leu Ser Tyr Lys Glu Asp Thr Lys Glu Leu Val Val Ala Lys 
                245                 250                 255     


Ala Gly Val Tyr Tyr Val Phe Phe Gln Leu Glu Leu Arg Arg Val Val 
            260                 265                 270         


Ala Gly Glu Gly Ser Gly Ser Val Ser Leu Ala Leu His Leu Gln Pro 
        275                 280                 285             


Leu Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala Leu Thr Val Asp Leu 
    290                 295                 300                 


Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala Phe Gly Phe Gln Gly 
305                 310                 315                 320 


Arg Leu Leu His Leu Ser Ala Gly Gln Arg Leu Gly Val His Leu His 
                325                 330                 335     


Thr Glu Ala Arg Ala Arg His Ala Trp Gln Leu Thr Gln Gly Ala Thr 
            340                 345                 350         


Val Leu Gly Leu Phe Arg Val Thr Pro Glu Ile Pro Ala Gly Gly Gly 
        355                 360                 365             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    370                 375                 380                 


Ser Gly Gly Gly Gly Ser Asp Pro Ala Gly Leu Leu Asp Leu Arg Gln 
385                 390                 395                 400 


Gly Met Phe Ala Gln Leu Val Ala Gln Asn Val Leu Leu Ile Asp Gly 
                405                 410                 415     


Pro Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala Gly Val Ser Leu Thr 
            420                 425                 430         


Gly Gly Leu Ser Tyr Lys Glu Asp Thr Lys Glu Leu Val Val Ala Lys 
        435                 440                 445             


Ala Gly Val Tyr Tyr Val Phe Phe Gln Leu Glu Leu Arg Arg Val Val 
    450                 455                 460                 


Ala Gly Glu Gly Ser Gly Ser Val Ser Leu Ala Leu His Leu Gln Pro 
465                 470                 475                 480 


Leu Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala Leu Thr Val Asp Leu 
                485                 490                 495     


Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala Phe Gly Phe Gln Gly 
            500                 505                 510         


Arg Leu Leu His Leu Ser Ala Gly Gln Arg Leu Gly Val His Leu His 
        515                 520                 525             


Thr Glu Ala Arg Ala Arg His Ala Trp Gln Leu Thr Gln Gly Ala Thr 
    530                 535                 540                 


Val Leu Gly Leu Phe Arg Val Thr Pro Glu Ile Pro Ala Gly Gly Gly 
545                 550                 555                 560 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
                565                 570                 575     


Ser Gly Gly Gly Gly Ser Asp Pro Ala Gly Leu Leu Asp Leu Arg Gln 
            580                 585                 590         


Gly Met Phe Ala Gln Leu Val Ala Gln Asn Val Leu Leu Ile Asp Gly 
        595                 600                 605             


Pro Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala Gly Val Ser Leu Thr 
    610                 615                 620                 


Gly Gly Leu Ser Tyr Lys Glu Asp Thr Lys Glu Leu Val Val Ala Lys 
625                 630                 635                 640 


Ala Gly Val Tyr Tyr Val Phe Phe Gln Leu Glu Leu Arg Arg Val Val 
                645                 650                 655     


Ala Gly Glu Gly Ser Gly Ser Val Ser Leu Ala Leu His Leu Gln Pro 
            660                 665                 670         


Leu Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala Leu Thr Val Asp Leu 
        675                 680                 685             


Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala Phe Gly Phe Gln Gly 
    690                 695                 700                 


Arg Leu Leu His Leu Ser Ala Gly Gln Arg Leu Gly Val His Leu His 
705                 710                 715                 720 


Thr Glu Ala Arg Ala Arg His Ala Trp Gln Leu Thr Gln Gly Ala Thr 
                725                 730                 735     


Val Leu Gly Leu Phe Arg Val Thr Pro Glu Ile Pro Ala Ser 
            740                 745                 750 


<210>  74
<211>  2316
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  74

Ala Thr Gly Thr Cys Thr Cys Gly Cys Thr Cys Cys Gly Thr Gly Gly 
1               5                   10                  15      


Cys Cys Thr Thr Ala Gly Cys Thr Gly Thr Gly Cys Thr Cys Gly Cys 
            20                  25                  30          


Gly Cys Thr Ala Cys Thr Cys Thr Cys Thr Cys Thr Thr Thr Cys Thr 
        35                  40                  45              


Gly Gly Cys Cys Thr Gly Gly Ala Gly Gly Cys Cys Gly Thr Thr Ala 
    50                  55                  60                  


Thr Cys Cys Ala Cys Gly Thr Gly Ala Cys Cys Ala Ala Gly Gly Ala 
65                  70                  75                  80  


Ala Gly Thr Gly Ala Ala Ala Gly Ala Ala Gly Thr Gly Gly Cys Ala 
                85                  90                  95      


Ala Cys Gly Cys Thr Gly Thr Cys Cys Thr Gly Thr Gly Gly Thr Cys 
            100                 105                 110         


Ala Cys Ala Ala Thr Gly Thr Thr Thr Cys Thr Gly Thr Thr Gly Ala 
        115                 120                 125             


Ala Gly Ala Gly Cys Thr Gly Gly Cys Ala Cys Ala Ala Ala Cys Thr 
    130                 135                 140                 


Cys Gly Cys Ala Thr Cys Thr Ala Cys Thr Gly Gly Cys Ala Ala Ala 
145                 150                 155                 160 


Ala Gly Gly Ala Gly Ala Ala Gly Ala Ala Ala Ala Thr Gly Gly Thr 
                165                 170                 175     


Gly Cys Thr Gly Ala Cys Thr Ala Thr Gly Ala Thr Gly Thr Cys Thr 
            180                 185                 190         


Gly Gly Gly Gly Ala Cys Ala Thr Gly Ala Ala Thr Ala Thr Ala Thr 
        195                 200                 205             


Gly Gly Cys Cys Cys Gly Ala Gly Thr Ala Cys Ala Ala Gly Ala Ala 
    210                 215                 220                 


Cys Cys Gly Gly Ala Cys Cys Ala Thr Cys Thr Thr Thr Gly Ala Thr 
225                 230                 235                 240 


Ala Thr Cys Ala Cys Thr Ala Ala Thr Ala Ala Cys Cys Thr Cys Thr 
                245                 250                 255     


Cys Cys Ala Thr Thr Gly Thr Gly Ala Thr Cys Cys Thr Gly Gly Cys 
            260                 265                 270         


Thr Cys Thr Gly Cys Gly Cys Cys Cys Ala Thr Cys Thr Gly Ala Cys 
        275                 280                 285             


Gly Ala Gly Gly Gly Cys Ala Cys Ala Thr Ala Cys Gly Ala Gly Thr 
    290                 295                 300                 


Gly Thr Gly Thr Thr Gly Thr Thr Cys Thr Gly Gly Cys Cys Thr Ala 
305                 310                 315                 320 


Thr Gly Ala Ala Ala Ala Ala Gly Ala Cys Gly Cys Thr Thr Thr Cys 
                325                 330                 335     


Ala Ala Gly Cys Gly Gly Gly Ala Ala Cys Ala Cys Cys Thr Gly Gly 
            340                 345                 350         


Cys Thr Gly Ala Ala Gly Thr Gly Ala Cys Gly Thr Thr Ala Thr Cys 
        355                 360                 365             


Ala Gly Thr Cys Ala Ala Ala Gly Cys Thr Gly Ala Cys Thr Thr Cys 
    370                 375                 380                 


Cys Cys Thr Ala Cys Ala Cys Cys Thr Ala Gly Thr Ala Thr Ala Thr 
385                 390                 395                 400 


Cys Thr Gly Ala Cys Thr Thr Thr Gly Ala Ala Ala Thr Thr Cys Cys 
                405                 410                 415     


Ala Ala Cys Thr Thr Cys Thr Ala Ala Thr Ala Thr Thr Ala Gly Ala 
            420                 425                 430         


Ala Gly Gly Ala Thr Ala Ala Thr Thr Thr Gly Cys Thr Cys Ala Ala 
        435                 440                 445             


Cys Cys Thr Cys Thr Gly Gly Ala Gly Gly Thr Thr Thr Thr Cys Cys 
    450                 455                 460                 


Ala Gly Ala Gly Cys Cys Thr Cys Ala Cys Cys Thr Cys Thr Cys Cys 
465                 470                 475                 480 


Thr Gly Gly Thr Thr Gly Gly Ala Ala Ala Ala Thr Gly Gly Ala Gly 
                485                 490                 495     


Ala Ala Gly Ala Ala Thr Thr Ala Ala Ala Thr Gly Cys Cys Ala Thr 
            500                 505                 510         


Cys Ala Ala Cys Ala Cys Ala Ala Cys Ala Gly Thr Thr Thr Cys Cys 
        515                 520                 525             


Cys Ala Ala Gly Ala Thr Cys Cys Thr Gly Ala Ala Ala Cys Thr Gly 
    530                 535                 540                 


Ala Gly Cys Thr Cys Thr Ala Thr Gly Cys Thr Gly Thr Thr Ala Gly 
545                 550                 555                 560 


Cys Ala Gly Cys Ala Ala Ala Cys Thr Gly Gly Ala Thr Thr Thr Cys 
                565                 570                 575     


Ala Ala Thr Ala Thr Gly Ala Cys Ala Ala Cys Cys Ala Ala Cys Cys 
            580                 585                 590         


Ala Cys Ala Gly Cys Thr Thr Cys Ala Thr Gly Thr Gly Thr Cys Thr 
        595                 600                 605             


Cys Ala Thr Cys Ala Ala Gly Thr Ala Thr Gly Gly Ala Cys Ala Thr 
    610                 615                 620                 


Thr Thr Ala Ala Gly Ala Gly Thr Gly Ala Ala Thr Cys Ala Gly Ala 
625                 630                 635                 640 


Cys Cys Thr Thr Cys Ala Ala Cys Thr Gly Gly Ala Ala Thr Ala Cys 
                645                 650                 655     


Ala Ala Cys Cys Ala Ala Gly Cys Ala Ala Gly Ala Gly Cys Ala Thr 
            660                 665                 670         


Thr Thr Thr Cys Cys Thr Gly Ala Thr Ala Ala Cys Gly Gly Ala Gly 
        675                 680                 685             


Gly Cys Gly Gly Ala Gly Gly Ala Thr Cys Thr Gly Gly Thr Gly Gly 
    690                 695                 700                 


Thr Gly Gly Ala Gly Gly Thr Thr Cys Thr Gly Gly Thr Gly Gly Thr 
705                 710                 715                 720 


Gly Gly Gly Gly Gly Ala Thr Cys Thr Gly Gly Ala Gly Gly Cys Gly 
                725                 730                 735     


Gly Ala Gly Gly Ala Thr Cys Thr Gly Gly Cys Cys Cys Gly Cys Ala 
            740                 745                 750         


Thr Thr Cys Cys Cys Thr Gly Cys Gly Cys Thr Ala Cys Thr Thr Thr 
        755                 760                 765             


Gly Thr Gly Ala Cys Cys Gly Cys Thr Gly Thr Thr Ala Gly Cys Cys 
    770                 775                 780                 


Gly Cys Cys Cys Gly Gly Gly Cys Cys Thr Gly Gly Gly Thr Gly Ala 
785                 790                 795                 800 


Ala Cys Cys Gly Cys Gly Thr Thr Ala Cys Ala Thr Gly Gly Ala Gly 
                805                 810                 815     


Gly Thr Cys Gly Gly Thr Thr Ala Thr Gly Thr Gly Gly Ala Thr Gly 
            820                 825                 830         


Ala Cys Ala Cys Gly Gly Ala Gly Thr Thr Thr Gly Thr Gly Cys Gly 
        835                 840                 845             


Thr Thr Thr Cys Gly Ala Thr Thr Cys Ala Gly Ala Cys Gly Cys Thr 
    850                 855                 860                 


Gly Ala Gly Ala Ala Cys Cys Cys Gly Cys Gly Thr Thr Ala Cys Gly 
865                 870                 875                 880 


Ala Ala Cys Cys Gly Cys Gly Thr Gly Cys Ala Ala Gly Ala Thr Gly 
                885                 890                 895     


Gly Ala Thr Gly Gly Ala Ala Cys Ala Gly Gly Ala Ala Gly Gly Cys 
            900                 905                 910         


Cys Cys Gly Gly Ala Ala Thr Ala Thr Thr Gly Gly Gly Ala Ala Ala 
        915                 920                 925             


Gly Ala Gly Ala Gly Ala Cys Cys Cys Ala Ala Ala Ala Gly Gly Cys 
    930                 935                 940                 


Ala Ala Ala Ala Gly Gly Cys Ala Ala Cys Gly Ala Ala Cys Ala Ala 
945                 950                 955                 960 


Ala Gly Cys Thr Thr Cys Cys Gly Thr Gly Thr Gly Gly Ala Cys Cys 
                965                 970                 975     


Thr Gly Cys Gly Thr Ala Cys Cys Cys Thr Gly Cys Thr Gly Gly Gly 
            980                 985                 990         


Cys Gly Cys Cys Thr Ala Cys Ala  Ala Cys Cys Ala Ala  Thr Cys Ala 
        995                 1000                 1005             


Ala Ala  Ala Gly Gly Thr Gly  Gly Cys Thr Cys Gly  Cys Ala Cys 
    1010                 1015                 1020             


Ala Cys  Gly Ala Thr Cys Cys  Ala Gly Gly Thr Gly  Ala Thr Cys 
    1025                 1030                 1035             


Ala Gly  Cys Gly Gly Cys Thr  Gly Cys Gly Ala Gly  Gly Thr Thr 
    1040                 1045                 1050             


Gly Gly  Thr Ala Gly Cys Gly  Ala Thr Gly Gly Cys  Cys Gly Thr 
    1055                 1060                 1065             


Cys Thr  Gly Cys Thr Gly Cys  Gly Cys Gly Gly Cys  Thr Ala Thr 
    1070                 1075                 1080             


Cys Ala  Gly Cys Ala Ala Thr  Ala Cys Gly Cys Cys  Thr Ala Cys 
    1085                 1090                 1095             


Gly Ala  Cys Gly Gly Thr Thr  Gly Cys Gly Ala Thr  Thr Ala Thr 
    1100                 1105                 1110             


Ala Thr  Cys Gly Cys Ala Cys  Thr Gly Ala Ala Thr  Gly Ala Ala 
    1115                 1120                 1125             


Gly Ala  Cys Cys Thr Gly Ala  Ala Ala Ala Cys Cys  Thr Gly Gly 
    1130                 1135                 1140             


Ala Cys  Gly Gly Cys Gly Gly  Cys Cys Gly Ala Thr  Ala Thr Gly 
    1145                 1150                 1155             


Gly Cys  Ala Gly Cys Thr Cys  Thr Gly Ala Thr Thr  Ala Cys Gly 
    1160                 1165                 1170             


Ala Ala  Gly Cys Ala Cys Ala  Ala Ala Thr Gly Gly  Gly Ala Ala 
    1175                 1180                 1185             


Cys Ala  Gly Gly Cys Thr Gly  Gly Cys Gly Ala Gly  Gly Cys Gly 
    1190                 1195                 1200             


Gly Ala  Ala Ala Gly Ala Cys  Thr Gly Cys Gly Cys  Gly Cys Cys 
    1205                 1210                 1215             


Thr Ala  Cys Cys Thr Gly Gly  Ala Gly Gly Gly Thr  Ala Cys Cys 
    1220                 1225                 1230             


Thr Gly  Cys Gly Thr Gly Gly  Ala Ala Thr Gly Gly  Cys Thr Gly 
    1235                 1240                 1245             


Cys Gly  Thr Cys Gly Cys Thr  Ala Thr Cys Thr Gly  Ala Ala Gly 
    1250                 1255                 1260             


Ala Ala  Cys Gly Gly Cys Ala  Ala Thr Gly Cys Cys  Ala Cys Cys 
    1265                 1270                 1275             


Thr Thr  Gly Cys Thr Gly Cys  Gly Thr Ala Cys Gly  Gly Ala Thr 
    1280                 1285                 1290             


Ala Gly  Cys Cys Cys Gly Ala  Ala Ala Gly Cys Ala  Cys Ala Thr 
    1295                 1300                 1305             


Gly Thr  Thr Ala Cys Cys Cys  Ala Cys Cys Ala Cys  Ala Gly Cys 
    1310                 1315                 1320             


Cys Gly  Cys Cys Cys Cys Gly  Ala Gly Gly Ala Cys  Ala Ala Gly 
    1325                 1330                 1335             


Gly Thr  Thr Ala Cys Gly Cys  Thr Gly Cys Gly Thr  Thr Gly Thr 
    1340                 1345                 1350             


Thr Gly  Gly Gly Cys Thr Cys  Thr Gly Gly Gly Cys  Thr Thr Thr 
    1355                 1360                 1365             


Thr Ala  Thr Cys Cys Gly Gly  Cys Gly Gly Ala Thr  Ala Thr Thr 
    1370                 1375                 1380             


Ala Cys  Cys Cys Thr Gly Ala  Cys Gly Thr Gly Gly  Cys Ala Gly 
    1385                 1390                 1395             


Cys Thr  Gly Ala Ala Cys Gly  Gly Thr Gly Ala Ala  Gly Ala Gly 
    1400                 1405                 1410             


Cys Thr  Gly Ala Thr Cys Cys  Ala Ala Gly Ala Thr  Ala Thr Gly 
    1415                 1420                 1425             


Gly Ala  Ala Cys Thr Gly Gly  Thr Gly Gly Ala Ala  Ala Cys Cys 
    1430                 1435                 1440             


Cys Gly  Thr Cys Cys Gly Thr  Gly Cys Gly Gly Cys  Gly Ala Thr 
    1445                 1450                 1455             


Gly Gly  Cys Ala Cys Gly Thr  Thr Cys Cys Ala Gly  Ala Ala Ala 
    1460                 1465                 1470             


Thr Gly  Gly Gly Cys Ala Ala  Gly Cys Gly Thr Gly  Gly Thr Thr 
    1475                 1480                 1485             


Gly Thr  Cys Cys Cys Gly Cys  Thr Gly Gly Gly Thr  Ala Ala Ala 
    1490                 1495                 1500             


Gly Ala  Ala Cys Ala Ala Thr  Ala Cys Thr Ala Cys  Ala Cys Cys 
    1505                 1510                 1515             


Thr Gly  Thr Cys Ala Thr Gly  Thr Thr Thr Ala Cys  Cys Ala Cys 
    1520                 1525                 1530             


Cys Ala  Gly Gly Gly Thr Cys  Thr Gly Cys Cys Gly  Gly Ala Ala 
    1535                 1540                 1545             


Cys Cys  Gly Cys Thr Gly Ala  Cys Gly Cys Thr Gly  Cys Gly Thr 
    1550                 1555                 1560             


Thr Gly  Gly Gly Cys Ala Gly  Cys Thr Gly Cys Gly  Gly Gly Thr 
    1565                 1570                 1575             


Gly Gly  Cys Cys Cys Cys Ala  Gly Ala Gly Gly Gly  Cys Cys Cys 
    1580                 1585                 1590             


Ala Cys  Ala Ala Thr Cys Ala  Ala Gly Cys Cys Cys  Thr Gly Thr 
    1595                 1600                 1605             


Cys Cys  Thr Cys Cys Ala Thr  Gly Cys Ala Ala Ala  Thr Gly Cys 
    1610                 1615                 1620             


Cys Cys  Ala Gly Cys Ala Cys  Cys Thr Ala Ala Cys  Gly Cys Cys 
    1625                 1630                 1635             


Gly Cys  Cys Gly Gly Thr Gly  Gly Ala Cys Cys Ala  Thr Cys Cys 
    1640                 1645                 1650             


Gly Thr  Cys Thr Thr Cys Ala  Thr Cys Thr Thr Cys  Cys Cys Thr 
    1655                 1660                 1665             


Cys Cys  Ala Ala Ala Gly Ala  Thr Cys Ala Ala Gly  Gly Ala Thr 
    1670                 1675                 1680             


Gly Thr  Ala Cys Thr Cys Ala  Thr Gly Ala Thr Cys  Thr Cys Cys 
    1685                 1690                 1695             


Cys Thr  Gly Ala Gly Cys Cys  Cys Cys Ala Thr Ala  Gly Thr Cys 
    1700                 1705                 1710             


Ala Cys  Ala Thr Gly Thr Gly  Thr Gly Gly Thr Gly  Gly Thr Gly 
    1715                 1720                 1725             


Gly Ala  Thr Gly Thr Gly Ala  Gly Cys Gly Ala Gly  Gly Ala Thr 
    1730                 1735                 1740             


Gly Ala  Cys Cys Cys Ala Gly  Ala Thr Gly Thr Cys  Cys Ala Gly 
    1745                 1750                 1755             


Ala Thr  Cys Ala Gly Cys Thr  Gly Gly Thr Thr Thr  Gly Thr Gly 
    1760                 1765                 1770             


Ala Ala  Cys Ala Ala Cys Gly  Thr Gly Gly Ala Ala  Gly Thr Ala 
    1775                 1780                 1785             


Cys Ala  Cys Ala Cys Ala Gly  Cys Thr Cys Ala Gly  Ala Cys Ala 
    1790                 1795                 1800             


Cys Ala  Ala Ala Cys Cys Cys  Ala Thr Ala Gly Ala  Gly Ala Gly 
    1805                 1810                 1815             


Gly Ala  Thr Thr Ala Cys Ala  Ala Cys Ala Gly Thr  Ala Cys Thr 
    1820                 1825                 1830             


Cys Thr  Cys Cys Gly Gly Gly  Thr Gly Gly Thr Cys  Ala Gly Thr 
    1835                 1840                 1845             


Gly Cys  Cys Cys Thr Cys Cys  Cys Cys Ala Thr Cys  Cys Ala Gly 
    1850                 1855                 1860             


Cys Ala  Cys Cys Ala Gly Gly  Ala Cys Thr Gly Gly  Ala Thr Gly 
    1865                 1870                 1875             


Ala Gly  Thr Gly Gly Cys Ala  Ala Gly Gly Ala Gly  Thr Thr Cys 
    1880                 1885                 1890             


Ala Ala  Ala Thr Gly Cys Ala  Ala Gly Gly Thr Cys  Ala Ala Cys 
    1895                 1900                 1905             


Ala Ala  Cys Ala Ala Ala Gly  Ala Cys Cys Thr Cys  Cys Cys Ala 
    1910                 1915                 1920             


Gly Cys  Gly Cys Cys Cys Ala  Thr Cys Gly Ala Gly  Ala Gly Ala 
    1925                 1930                 1935             


Ala Cys  Cys Ala Thr Cys Thr  Cys Ala Ala Ala Ala  Cys Cys Cys 
    1940                 1945                 1950             


Ala Ala  Ala Gly Gly Gly Thr  Cys Ala Gly Thr Ala  Ala Gly Ala 
    1955                 1960                 1965             


Gly Cys  Thr Cys Cys Ala Cys  Ala Gly Gly Thr Ala  Thr Ala Thr 
    1970                 1975                 1980             


Gly Thr  Cys Thr Thr Gly Cys  Cys Thr Cys Cys Ala  Cys Cys Ala 
    1985                 1990                 1995             


Gly Ala  Ala Gly Ala Ala Gly  Ala Gly Ala Thr Gly  Ala Cys Thr 
    2000                 2005                 2010             


Ala Ala  Gly Ala Ala Ala Cys  Ala Gly Gly Thr Cys  Ala Cys Thr 
    2015                 2020                 2025             


Cys Thr  Gly Ala Cys Cys Thr  Gly Cys Ala Thr Gly  Gly Thr Cys 
    2030                 2035                 2040             


Ala Cys  Ala Gly Ala Cys Thr  Thr Cys Ala Thr Gly  Cys Cys Thr 
    2045                 2050                 2055             


Gly Ala  Ala Gly Ala Cys Ala  Thr Thr Thr Ala Cys  Gly Thr Gly 
    2060                 2065                 2070             


Gly Ala  Gly Thr Gly Gly Ala  Cys Cys Ala Ala Cys  Ala Ala Cys 
    2075                 2080                 2085             


Gly Gly  Gly Ala Ala Ala Ala  Cys Ala Gly Ala Gly  Cys Thr Ala 
    2090                 2095                 2100             


Ala Ala  Cys Thr Ala Cys Ala  Ala Gly Ala Ala Cys  Ala Cys Thr 
    2105                 2110                 2115             


Gly Ala  Ala Cys Cys Ala Gly  Thr Cys Cys Thr Gly  Gly Ala Cys 
    2120                 2125                 2130             


Thr Cys  Thr Gly Ala Thr Gly  Gly Thr Thr Cys Thr  Thr Ala Cys 
    2135                 2140                 2145             


Thr Thr  Cys Ala Thr Gly Thr  Ala Cys Ala Gly Cys  Ala Ala Gly 
    2150                 2155                 2160             


Cys Thr  Gly Ala Gly Ala Gly  Thr Gly Gly Ala Ala  Ala Ala Gly 
    2165                 2170                 2175             


Ala Ala  Gly Ala Ala Cys Thr  Gly Gly Gly Thr Gly  Gly Ala Ala 
    2180                 2185                 2190             


Ala Gly  Ala Ala Ala Thr Ala  Gly Cys Thr Ala Cys  Thr Cys Cys 
    2195                 2200                 2205             


Thr Gly  Thr Thr Cys Ala Gly  Thr Gly Gly Thr Cys  Cys Ala Cys 
    2210                 2215                 2220             


Gly Ala  Gly Gly Gly Thr Cys  Thr Gly Cys Ala Cys  Ala Ala Thr 
    2225                 2230                 2235             


Cys Ala  Cys Cys Ala Cys Ala  Cys Gly Ala Cys Thr  Ala Ala Gly 
    2240                 2245                 2250             


Ala Gly  Cys Thr Thr Cys Thr  Cys Cys Cys Gly Gly  Ala Cys Thr 
    2255                 2260                 2265             


Cys Cys  Gly Gly Gly Thr Ala  Ala Ala Gly Gly Cys  Gly Gly Ala 
    2270                 2275                 2280             


Thr Cys  Ala Cys Ala Thr Cys  Ala Cys Cys Ala Thr  Cys Ala Cys 
    2285                 2290                 2295             


Cys Ala  Thr Cys Ala Cys Cys  Ala Thr Cys Ala Cys  Thr Ala Gly 
    2300                 2305                 2310             


Thr Gly  Ala 
    2315     


<210>  75
<211>  770
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  75

Met Ser Arg Ser Val Ala Leu Ala Val Leu Ala Leu Leu Ser Leu Ser 
1               5                   10                  15      


Gly Leu Glu Ala Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala 
            20                  25                  30          


Thr Leu Ser Cys Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr 
        35                  40                  45              


Arg Ile Tyr Trp Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser 
    50                  55                  60                  


Gly Asp Met Asn Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp 
65                  70                  75                  80  


Ile Thr Asn Asn Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp 
                85                  90                  95      


Glu Gly Thr Tyr Glu Cys Val Val Leu Ala Tyr Glu Lys Asp Ala Phe 
            100                 105                 110         


Lys Arg Glu His Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe 
        115                 120                 125             


Pro Thr Pro Ser Ile Ser Asp Phe Glu Ile Pro Thr Ser Asn Ile Arg 
    130                 135                 140                 


Arg Ile Ile Cys Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser 
145                 150                 155                 160 


Trp Leu Glu Asn Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser 
                165                 170                 175     


Gln Asp Pro Glu Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe 
            180                 185                 190         


Asn Met Thr Thr Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His 
        195                 200                 205             


Leu Arg Val Asn Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His 
    210                 215                 220                 


Phe Pro Asp Asn Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
225                 230                 235                 240 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Pro His Ser Leu Arg Tyr Phe 
                245                 250                 255     


Val Thr Ala Val Ser Arg Pro Gly Leu Gly Glu Pro Arg Tyr Met Glu 
            260                 265                 270         


Val Gly Tyr Val Asp Asp Thr Glu Phe Val Arg Phe Asp Ser Asp Ala 
        275                 280                 285             


Glu Asn Pro Arg Tyr Glu Pro Arg Ala Arg Trp Met Glu Gln Glu Gly 
    290                 295                 300                 


Pro Glu Tyr Trp Glu Arg Glu Thr Gln Lys Ala Lys Gly Asn Glu Gln 
305                 310                 315                 320 


Ser Phe Arg Val Asp Leu Arg Thr Leu Leu Gly Ala Tyr Asn Gln Ser 
                325                 330                 335     


Lys Gly Gly Ser His Thr Ile Gln Val Ile Ser Gly Cys Glu Val Gly 
            340                 345                 350         


Ser Asp Gly Arg Leu Leu Arg Gly Tyr Gln Gln Tyr Ala Tyr Asp Gly 
        355                 360                 365             


Cys Asp Tyr Ile Ala Leu Asn Glu Asp Leu Lys Thr Trp Thr Ala Ala 
    370                 375                 380                 


Asp Met Ala Ala Leu Ile Thr Lys His Lys Trp Glu Gln Ala Gly Glu 
385                 390                 395                 400 


Ala Glu Arg Leu Arg Ala Tyr Leu Glu Gly Thr Cys Val Glu Trp Leu 
                405                 410                 415     


Arg Arg Tyr Leu Lys Asn Gly Asn Ala Thr Leu Leu Arg Thr Asp Ser 
            420                 425                 430         


Pro Lys Ala His Val Thr His His Ser Arg Pro Glu Asp Lys Val Thr 
        435                 440                 445             


Leu Arg Cys Trp Ala Leu Gly Phe Tyr Pro Ala Asp Ile Thr Leu Thr 
    450                 455                 460                 


Trp Gln Leu Asn Gly Glu Glu Leu Ile Gln Asp Met Glu Leu Val Glu 
465                 470                 475                 480 


Thr Arg Pro Cys Gly Asp Gly Thr Phe Gln Lys Trp Ala Ser Val Val 
                485                 490                 495     


Val Pro Leu Gly Lys Glu Gln Tyr Tyr Thr Cys His Val Tyr His Gln 
            500                 505                 510         


Gly Leu Pro Glu Pro Leu Thr Leu Arg Trp Ala Ala Ala Gly Gly Pro 
        515                 520                 525             


Arg Gly Pro Thr Ile Lys Pro Cys Pro Pro Cys Lys Cys Pro Ala Pro 
    530                 535                 540                 


Asn Ala Ala Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Ile Lys 
545                 550                 555                 560 


Asp Val Leu Met Ile Ser Leu Ser Pro Ile Val Thr Cys Val Val Val 
                565                 570                 575     


Asp Val Ser Glu Asp Asp Pro Asp Val Gln Ile Ser Trp Phe Val Asn 
            580                 585                 590         


Asn Val Glu Val His Thr Ala Gln Thr Gln Thr His Arg Glu Asp Tyr 
        595                 600                 605             


Asn Ser Thr Leu Arg Val Val Ser Ala Leu Pro Ile Gln His Gln Asp 
    610                 615                 620                 


Trp Met Ser Gly Lys Glu Phe Lys Cys Lys Val Asn Asn Lys Asp Leu 
625                 630                 635                 640 


Pro Ala Pro Ile Glu Arg Thr Ile Ser Lys Pro Lys Gly Ser Val Arg 
                645                 650                 655     


Ala Pro Gln Val Tyr Val Leu Pro Pro Pro Glu Glu Glu Met Thr Lys 
            660                 665                 670         


Lys Gln Val Thr Leu Thr Cys Met Val Thr Asp Phe Met Pro Glu Asp 
        675                 680                 685             


Ile Tyr Val Glu Trp Thr Asn Asn Gly Lys Thr Glu Leu Asn Tyr Lys 
    690                 695                 700                 


Asn Thr Glu Pro Val Leu Asp Ser Asp Gly Ser Tyr Phe Met Tyr Ser 
705                 710                 715                 720 


Lys Leu Arg Val Glu Lys Lys Asn Trp Val Glu Arg Asn Ser Tyr Ser 
                725                 730                 735     


Cys Ser Val Val His Glu Gly Leu His Asn His His Thr Thr Lys Ser 
            740                 745                 750         


Phe Ser Arg Thr Pro Gly Lys Gly Gly Ser His His His His His His 
        755                 760                 765             


His His 
    770 


<210>  76
<211>  2166
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  76
atgtcccgct ccgtggcgct tgcggtgctg gccctgctgt cgttgtccgg gctggaagcg       60

tccattatca acttcgagaa actgggggga ggagcctcag gaggaggagg atccgggggt      120

ggaggtagca tgattcaaaa gacccctcaa atccaggtct actcgtgcca cccacccgag      180

aacggaaagc ctaatatcct gaactgttac gtgacccaat tccacccgcc gcatatcgag      240

atccagatgc tcaagaacgg caagaagatc cccaaggtgg aaatgtccga catgagcttt      300

tccaaggatt ggtcgttcta tatcctggct cataccgagt tcacccccac cgaaaccgat      360

acttacgcct gccgcgtcaa gcacgcctca atggcggagc ctaagaccgt gtactgggac      420

cgggacatgg gtggcggggg gtccggagga ggtggatccg gcggaggggg atctggcgga      480

ggcggatcag gaggtggcgg ctctgaccct gcaggcctgc tggatctgcg gcagggcatg      540

ttcgcacaac tcgtggccca gaacgtgctg ctgatcgatg gaccgctgtc ctggtactcc      600

gacccgggac ttgccggagt gtcactgact ggaggattgt cctacgccga agatacgaag      660

gagctcgtcg tggcgaaggc cggagtgtac tatgtgttct tccagctcga actccggaga      720

gtcgtggccg gggaaggctc cggctccgtg tcacttgccc tgcacctcca gccacttcgg      780

tcggccgctg gagccgccgc actggccctg accgtcgacc tccctcctgc gtcctccgag      840

gctcgcaact cggccttcgg attccaaggg cgccttctgc acctgtccgc gggacagagg      900

ctgggggtgc atctgcatac tgaagcgcgg gcacggcatg cttggcagct gactcaggga      960

gcaactgtcc tgggtctgtt ccgcgtgact ccggaaatcc ccgccggtgg aggtggctca     1020

ggaggcggcg gcagcggtgg aggagggagc ggaggaggcg gatccggtgg aggcggaagc     1080

gaccctgccg gactcctgga tctgcggcag ggcatgttcg cccagttggt ggcgcagaac     1140

gtcctgctca ttgacgggcc gctgtcgtgg tacagcgatc cgggcttggc cggagtctcg     1200

ctgaccggag gactcagcta cgccgaagat accaaggagc tggtcgtggc caaggccgga     1260

gtgtactacg tgttcttcca actggaactg cgccgggtgg tggctggcga aggatccggg     1320

tcggtgtccc tggccctgca tctgcagcct ctgcgctcag ccgcaggagc agccgccttg     1380

gcgctcaccg tggaccttcc gcccgcctcc tcggaagccc ggaacagcgc cttcggcttc     1440

caaggcagac tcctgcactt gagcgcgggc cagagactgg gagtgcacct ccacaccgaa     1500

gcgcgcgcaa ggcacgcctg gcagctcacc cagggagcca ccgtgctggg cttgtttcga     1560

gtcacccccg agatcccagc cggcggagga ggttccggtg gcggtggatc aggcggtgga     1620

ggctcgggtg gagggggtag cggagggggt ggttccgacc ccgcaggact gctggacctc     1680

cggcagggga tgttcgcgca actggtggct cagaatgtcc tgctgattga cggccccctg     1740

tcgtggtact cggaccctgg ccttgccggc gtgtccttga ctggagggct gtcgtacgcc     1800

gaggacacta aggagctggt cgtggccaaa gccggcgtgt actacgtgtt ctttcagctg     1860

gaactgagga gagtggtggc gggagaaggc agcggctcag tgtccctcgc cctgcacctt     1920

caaccactcc gctctgccgc tggtgcagct gcgctcgccc tcactgtgga tcttccaccg     1980

gcaagctccg aggccagaaa ctccgccttc gggttccagg ggaggctgct gcatctctcc     2040

gccggccaga gactgggcgt gcacttgcac actgaggcta gggctcgcca tgcctggcag     2100

ctgacccagg gcgccactgt gctgggactg ttccgggtga ccccagaaat cccggcctcc     2160

tgatag                                                                2166


<210>  77
<211>  720
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  77

Met Ser Arg Ser Val Ala Leu Ala Val Leu Ala Leu Leu Ser Leu Ser 
1               5                   10                  15      


Gly Leu Glu Ala Ser Ile Ile Asn Phe Glu Lys Leu Gly Gly Gly Ala 
            20                  25                  30          


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Met Ile Gln Lys Thr 
        35                  40                  45              


Pro Gln Ile Gln Val Tyr Ser Cys His Pro Pro Glu Asn Gly Lys Pro 
    50                  55                  60                  


Asn Ile Leu Asn Cys Tyr Val Thr Gln Phe His Pro Pro His Ile Glu 
65                  70                  75                  80  


Ile Gln Met Leu Lys Asn Gly Lys Lys Ile Pro Lys Val Glu Met Ser 
                85                  90                  95      


Asp Met Ser Phe Ser Lys Asp Trp Ser Phe Tyr Ile Leu Ala His Thr 
            100                 105                 110         


Glu Phe Thr Pro Thr Glu Thr Asp Thr Tyr Ala Cys Arg Val Lys His 
        115                 120                 125             


Ala Ser Met Ala Glu Pro Lys Thr Val Tyr Trp Asp Arg Asp Met Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
145                 150                 155                 160 


Gly Gly Ser Gly Gly Gly Gly Ser Asp Pro Ala Gly Leu Leu Asp Leu 
                165                 170                 175     


Arg Gln Gly Met Phe Ala Gln Leu Val Ala Gln Asn Val Leu Leu Ile 
            180                 185                 190         


Asp Gly Pro Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala Gly Val Ser 
        195                 200                 205             


Leu Thr Gly Gly Leu Ser Tyr Ala Glu Asp Thr Lys Glu Leu Val Val 
    210                 215                 220                 


Ala Lys Ala Gly Val Tyr Tyr Val Phe Phe Gln Leu Glu Leu Arg Arg 
225                 230                 235                 240 


Val Val Ala Gly Glu Gly Ser Gly Ser Val Ser Leu Ala Leu His Leu 
                245                 250                 255     


Gln Pro Leu Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala Leu Thr Val 
            260                 265                 270         


Asp Leu Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala Phe Gly Phe 
        275                 280                 285             


Gln Gly Arg Leu Leu His Leu Ser Ala Gly Gln Arg Leu Gly Val His 
    290                 295                 300                 


Leu His Thr Glu Ala Arg Ala Arg His Ala Trp Gln Leu Thr Gln Gly 
305                 310                 315                 320 


Ala Thr Val Leu Gly Leu Phe Arg Val Thr Pro Glu Ile Pro Ala Gly 
                325                 330                 335     


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            340                 345                 350         


Gly Gly Ser Gly Gly Gly Gly Ser Asp Pro Ala Gly Leu Leu Asp Leu 
        355                 360                 365             


Arg Gln Gly Met Phe Ala Gln Leu Val Ala Gln Asn Val Leu Leu Ile 
    370                 375                 380                 


Asp Gly Pro Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala Gly Val Ser 
385                 390                 395                 400 


Leu Thr Gly Gly Leu Ser Tyr Ala Glu Asp Thr Lys Glu Leu Val Val 
                405                 410                 415     


Ala Lys Ala Gly Val Tyr Tyr Val Phe Phe Gln Leu Glu Leu Arg Arg 
            420                 425                 430         


Val Val Ala Gly Glu Gly Ser Gly Ser Val Ser Leu Ala Leu His Leu 
        435                 440                 445             


Gln Pro Leu Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala Leu Thr Val 
    450                 455                 460                 


Asp Leu Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala Phe Gly Phe 
465                 470                 475                 480 


Gln Gly Arg Leu Leu His Leu Ser Ala Gly Gln Arg Leu Gly Val His 
                485                 490                 495     


Leu His Thr Glu Ala Arg Ala Arg His Ala Trp Gln Leu Thr Gln Gly 
            500                 505                 510         


Ala Thr Val Leu Gly Leu Phe Arg Val Thr Pro Glu Ile Pro Ala Gly 
        515                 520                 525             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    530                 535                 540                 


Gly Gly Ser Gly Gly Gly Gly Ser Asp Pro Ala Gly Leu Leu Asp Leu 
545                 550                 555                 560 


Arg Gln Gly Met Phe Ala Gln Leu Val Ala Gln Asn Val Leu Leu Ile 
                565                 570                 575     


Asp Gly Pro Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala Gly Val Ser 
            580                 585                 590         


Leu Thr Gly Gly Leu Ser Tyr Ala Glu Asp Thr Lys Glu Leu Val Val 
        595                 600                 605             


Ala Lys Ala Gly Val Tyr Tyr Val Phe Phe Gln Leu Glu Leu Arg Arg 
    610                 615                 620                 


Val Val Ala Gly Glu Gly Ser Gly Ser Val Ser Leu Ala Leu His Leu 
625                 630                 635                 640 


Gln Pro Leu Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala Leu Thr Val 
                645                 650                 655     


Asp Leu Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala Phe Gly Phe 
            660                 665                 670         


Gln Gly Arg Leu Leu His Leu Ser Ala Gly Gln Arg Leu Gly Val His 
        675                 680                 685             


Leu His Thr Glu Ala Arg Ala Arg His Ala Trp Gln Leu Thr Gln Gly 
    690                 695                 700                 


Ala Thr Val Leu Gly Leu Phe Arg Val Thr Pro Glu Ile Pro Ala Ser 
705                 710                 715                 720 


<210>  78
<211>  2316
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  78
atgtctcgct ccgtggcctt agctgtgctc gcgctactct ctctttctgg cctggaggcc       60

gttatccacg tgaccaagga agtgaaagaa gtggcaacgc tgtcctgtgg tcacaatgtt      120

tctgttgaag agctggcaca aactcgcatc tactggcaaa aggagaagaa aatggtgctg      180

actatgatgt ctggggacat gaatatatgg cccgagtaca agaaccggac catctttgat      240

atcactaata acctctccat tgtgatcctg gctctgcgcc catctgacga gggcacatac      300

gagtgtgttg ttctggccta tgaaaaagac gctttcaagc gggaacacct ggctgaagtg      360

acgttatcag tcaaagctga cttccctaca cctagtatat ctgactttga aattccaact      420

tctaatatta gaaggataat ttgctcaacc tctggaggtt ttccagagcc tcacctctcc      480

tggttggaaa atggagaaga attaaatgcc atcaacacaa cagtttccca agatcctgaa      540

actgagctct atgctgttag cagcaaactg gatttcaata tgacaaccaa ccacagcttc      600

atgtgtctca tcaagtatgg acatttaaga gtgaatcaga ccttcaactg gaatacaacc      660

aagcaagagc attttcctga taacggaggc ggaggatctg gtggtggagg ttctggtggt      720

gggggatctg gaggcggagg atctggccca cactcgatgc ggtatttcga gaccgccgtg      780

tcccggcccg gcctcgagga gccccggtac atctctgtcg gctatgtgga caacaaggag      840

ttcgtgcgct tcgacagcga cgcggagaat ccgagatatg agccgcgggc gccgtggatg      900

gagcaggagg ggccggagta ttgggagcgg gaaacacaga aagccaaggg ccaagagcag      960

tggttccgag tgagcctgag gaacctgctc ggcgcctaca accagagcgc gggcggctct     1020

cacacactcc agcagatgtc tggctgtgac ttggggtcgg actggcgcct cctccgcggg     1080

tacctgcagt tcgcctatga aggccgcgat tacatcgccc tgaacgaaga cctgaaaacg     1140

tggacggcgg cggacatggc ggcgcagatc acccgacgca agtgggagca gagtggtgct     1200

gcagagcatt acaaggccta cctggagggc gagtgcgtgg agtggctcca cagatacctg     1260

aagaacggga acgcgacgct gctgcgcaca gattccccaa aggcacatgt gacccatcac     1320

cccagatcta aaggtgaagt caccctgagg tgctgggccc tgggcttcta ccctgctgac     1380

atcaccctga cctggcagtt gaatggggag gagctgaccc aggacatgga gcttgtggag     1440

accaggcctt gcggggatgg aaccttccag aagtgggcat ctgtggtggt gcctcttggg     1500

aaggagcaga attacacatg ccgtgtgtac catgaggggc tgcctgagcc cctcaccctg     1560

agatgggcag ctgcgggtgg ccccagaggg cccacaatca agccctgtcc tccatgcaaa     1620

tgcccagcac ctaacgccgc cggtggacca tccgtcttca tcttccctcc aaagatcaag     1680

gatgtactca tgatctccct gagccccata gtcacatgtg tggtggtgga tgtgagcgag     1740

gatgacccag atgtccagat cagctggttt gtgaacaacg tggaagtaca cacagctcag     1800

acacaaaccc atagagagga ttacaacagt actctccggg tggtcagtgc cctccccatc     1860

cagcaccagg actggatgag tggcaaggag ttcaaatgca aggtcaacaa caaagacctc     1920

ccagcgccca tcgagagaac catctcaaaa cccaaagggt cagtaagagc tccacaggta     1980

tatgtcttgc ctccaccaga agaagagatg actaagaaac aggtcactct gacctgcatg     2040

gtcacagact tcatgcctga agacatttac gtggagtgga ccaacaacgg gaaaacagag     2100

ctaaactaca agaacactga accagtcctg gactctgatg gttcttactt catgtacagc     2160

aagctgagag tggaaaagaa gaactgggtg gaaagaaata gctactcctg ttcagtggtc     2220

cacgagggtc tgcacaatca ccacacgact aagagcttct cccggactcc gggtaaaggc     2280

ggatcacatc accatcacca tcaccatcac tagtga                               2316


<210>  79
<211>  770
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  79

Met Ser Arg Ser Val Ala Leu Ala Val Leu Ala Leu Leu Ser Leu Ser 
1               5                   10                  15      


Gly Leu Glu Ala Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala 
            20                  25                  30          


Thr Leu Ser Cys Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr 
        35                  40                  45              


Arg Ile Tyr Trp Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser 
    50                  55                  60                  


Gly Asp Met Asn Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp 
65                  70                  75                  80  


Ile Thr Asn Asn Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp 
                85                  90                  95      


Glu Gly Thr Tyr Glu Cys Val Val Leu Ala Tyr Glu Lys Asp Ala Phe 
            100                 105                 110         


Lys Arg Glu His Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe 
        115                 120                 125             


Pro Thr Pro Ser Ile Ser Asp Phe Glu Ile Pro Thr Ser Asn Ile Arg 
    130                 135                 140                 


Arg Ile Ile Cys Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser 
145                 150                 155                 160 


Trp Leu Glu Asn Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser 
                165                 170                 175     


Gln Asp Pro Glu Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe 
            180                 185                 190         


Asn Met Thr Thr Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His 
        195                 200                 205             


Leu Arg Val Asn Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His 
    210                 215                 220                 


Phe Pro Asp Asn Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
225                 230                 235                 240 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Pro His Ser Met Arg Tyr Phe 
                245                 250                 255     


Glu Thr Ala Val Ser Arg Pro Gly Leu Glu Glu Pro Arg Tyr Ile Ser 
            260                 265                 270         


Val Gly Tyr Val Asp Asn Lys Glu Phe Val Arg Phe Asp Ser Asp Ala 
        275                 280                 285             


Glu Asn Pro Arg Tyr Glu Pro Arg Ala Pro Trp Met Glu Gln Glu Gly 
    290                 295                 300                 


Pro Glu Tyr Trp Glu Arg Glu Thr Gln Lys Ala Lys Gly Gln Glu Gln 
305                 310                 315                 320 


Trp Phe Arg Val Ser Leu Arg Asn Leu Leu Gly Ala Tyr Asn Gln Ser 
                325                 330                 335     


Ala Gly Gly Ser His Thr Leu Gln Gln Met Ser Gly Cys Asp Leu Gly 
            340                 345                 350         


Ser Asp Trp Arg Leu Leu Arg Gly Tyr Leu Gln Phe Ala Tyr Glu Gly 
        355                 360                 365             


Arg Asp Tyr Ile Ala Leu Asn Glu Asp Leu Lys Thr Trp Thr Ala Ala 
    370                 375                 380                 


Asp Met Ala Ala Gln Ile Thr Arg Arg Lys Trp Glu Gln Ser Gly Ala 
385                 390                 395                 400 


Ala Glu His Tyr Lys Ala Tyr Leu Glu Gly Glu Cys Val Glu Trp Leu 
                405                 410                 415     


His Arg Tyr Leu Lys Asn Gly Asn Ala Thr Leu Leu Arg Thr Asp Ser 
            420                 425                 430         


Pro Lys Ala His Val Thr His His Pro Arg Ser Lys Gly Glu Val Thr 
        435                 440                 445             


Leu Arg Cys Trp Ala Leu Gly Phe Tyr Pro Ala Asp Ile Thr Leu Thr 
    450                 455                 460                 


Trp Gln Leu Asn Gly Glu Glu Leu Thr Gln Asp Met Glu Leu Val Glu 
465                 470                 475                 480 


Thr Arg Pro Cys Gly Asp Gly Thr Phe Gln Lys Trp Ala Ser Val Val 
                485                 490                 495     


Val Pro Leu Gly Lys Glu Gln Asn Tyr Thr Cys Arg Val Tyr His Glu 
            500                 505                 510         


Gly Leu Pro Glu Pro Leu Thr Leu Arg Trp Ala Ala Ala Gly Gly Pro 
        515                 520                 525             


Arg Gly Pro Thr Ile Lys Pro Cys Pro Pro Cys Lys Cys Pro Ala Pro 
    530                 535                 540                 


Asn Ala Ala Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Ile Lys 
545                 550                 555                 560 


Asp Val Leu Met Ile Ser Leu Ser Pro Ile Val Thr Cys Val Val Val 
                565                 570                 575     


Asp Val Ser Glu Asp Asp Pro Asp Val Gln Ile Ser Trp Phe Val Asn 
            580                 585                 590         


Asn Val Glu Val His Thr Ala Gln Thr Gln Thr His Arg Glu Asp Tyr 
        595                 600                 605             


Asn Ser Thr Leu Arg Val Val Ser Ala Leu Pro Ile Gln His Gln Asp 
    610                 615                 620                 


Trp Met Ser Gly Lys Glu Phe Lys Cys Lys Val Asn Asn Lys Asp Leu 
625                 630                 635                 640 


Pro Ala Pro Ile Glu Arg Thr Ile Ser Lys Pro Lys Gly Ser Val Arg 
                645                 650                 655     


Ala Pro Gln Val Tyr Val Leu Pro Pro Pro Glu Glu Glu Met Thr Lys 
            660                 665                 670         


Lys Gln Val Thr Leu Thr Cys Met Val Thr Asp Phe Met Pro Glu Asp 
        675                 680                 685             


Ile Tyr Val Glu Trp Thr Asn Asn Gly Lys Thr Glu Leu Asn Tyr Lys 
    690                 695                 700                 


Asn Thr Glu Pro Val Leu Asp Ser Asp Gly Ser Tyr Phe Met Tyr Ser 
705                 710                 715                 720 


Lys Leu Arg Val Glu Lys Lys Asn Trp Val Glu Arg Asn Ser Tyr Ser 
                725                 730                 735     


Cys Ser Val Val His Glu Gly Leu His Asn His His Thr Thr Lys Ser 
            740                 745                 750         


Phe Ser Arg Thr Pro Gly Lys Gly Gly Ser His His His His His His 
        755                 760                 765             


His His 
    770 


<210>  80
<211>  2169
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  80
atgtcccgct ccgtggcgct tgcggtgctg gccctgctgt cgttgtccgg gctggaagcg       60

cgagcccact acaacattgt gacatttggg ggaggagcct caggaggagg aggatccggg      120

ggtggaggta gcatgattca aaagacccct caaatccagg tctactcgtg ccacccaccc      180

gagaacggaa agcctaatat cctgaactgt tacgtgaccc aattccaccc gccgcatatc      240

gagatccaga tgctcaagaa cggcaagaag atccccaagg tggaaatgtc cgacatgagc      300

ttttccaagg attggtcgtt ctatatcctg gctcataccg agttcacccc caccgaaacc      360

gatacttacg cctgccgcgt caagcacgcc tcaatggcgg agcctaagac cgtgtactgg      420

gaccgggaca tgggtggcgg ggggtccgga ggaggtggat ccggcggagg gggatctggc      480

ggaggcggat caggaggtgg cggctctgac cctgcaggcc tgctggatct gcggcagggc      540

atgttcgcac aactcgtggc ccagaacgtg ctgctgatcg atggaccgct gtcctggtac      600

tccgacccgg gacttgccgg agtgtcactg actggaggat tgtcctacgc cgaagatacg      660

aaggagctcg tcgtggcgaa ggccggagtg tactatgtgt tcttccagct cgaactccgg      720

agagtcgtgg ccggggaagg ctccggctcc gtgtcacttg ccctgcacct ccagccactt      780

cggtcggccg ctggagccgc cgcactggcc ctgaccgtcg acctccctcc tgcgtcctcc      840

gaggctcgca actcggcctt cggattccaa gggcgccttc tgcacctgtc cgcgggacag      900

aggctggggg tgcatctgca tactgaagcg cgggcacggc atgcttggca gctgactcag      960

ggagcaactg tcctgggtct gttccgcgtg actccggaaa tccccgccgg tggaggtggc     1020

tcaggaggcg gcggcagcgg tggaggaggg agcggaggag gcggatccgg tggaggcgga     1080

agcgaccctg ccggactcct ggatctgcgg cagggcatgt tcgcccagtt ggtggcgcag     1140

aacgtcctgc tcattgacgg gccgctgtcg tggtacagcg atccgggctt ggccggagtc     1200

tcgctgaccg gaggactcag ctacgccgaa gataccaagg agctggtcgt ggccaaggcc     1260

ggagtgtact acgtgttctt ccaactggaa ctgcgccggg tggtggctgg cgaaggatcc     1320

gggtcggtgt ccctggccct gcatctgcag cctctgcgct cagccgcagg agcagccgcc     1380

ttggcgctca ccgtggacct tccgcccgcc tcctcggaag cccggaacag cgccttcggc     1440

ttccaaggca gactcctgca cttgagcgcg ggccagagac tgggagtgca cctccacacc     1500

gaagcgcgcg caaggcacgc ctggcagctc acccagggag ccaccgtgct gggcttgttt     1560

cgagtcaccc ccgagatccc agccggcgga ggaggttccg gtggcggtgg atcaggcggt     1620

ggaggctcgg gtggaggggg tagcggaggg ggtggttccg accccgcagg actgctggac     1680

ctccggcagg ggatgttcgc gcaactggtg gctcagaatg tcctgctgat tgacggcccc     1740

ctgtcgtggt actcggaccc tggccttgcc ggcgtgtcct tgactggagg gctgtcgtac     1800

aaggaggaca ctaaggagct ggtcgtggcc aaagccggcg tgtactacgt gttctttcag     1860

ctggaactga ggagagtggt ggcgggagaa ggcagcggct cagtgtccct cgccctgcac     1920

cttcaaccac tccgctctgc cgctggtgca gctgcgctcg ccctcactgt ggatcttcca     1980

ccggcaagct ccgaggccag aaactccgcc ttcgggttcc aggggaggct gctgcatctc     2040

tccgccggcc agagactggg cgtgcacttg cacactgagg ctagggctcg ccatgcctgg     2100

cagctgaccc agggcgccac tgtgctggga ctgttccggg tgaccccaga aatcccggcc     2160

tcctgatag                                                             2169


<210>  81
<211>  720
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  81

Ser Arg Ser Val Ala Leu Ala Val Leu Ala Leu Leu Ser Leu Ser Gly 
1               5                   10                  15      


Leu Glu Ala Arg Ala His Tyr Asn Ile Val Thr Phe Gly Gly Gly Ala 
            20                  25                  30          


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Met Ile Gln Lys Thr 
        35                  40                  45              


Pro Gln Ile Gln Val Tyr Ser Cys His Pro Pro Glu Asn Gly Lys Pro 
    50                  55                  60                  


Asn Ile Leu Asn Cys Tyr Val Thr Gln Phe His Pro Pro His Ile Glu 
65                  70                  75                  80  


Ile Gln Met Leu Lys Asn Gly Lys Lys Ile Pro Lys Val Glu Met Ser 
                85                  90                  95      


Asp Met Ser Phe Ser Lys Asp Trp Ser Phe Tyr Ile Leu Ala His Thr 
            100                 105                 110         


Glu Phe Thr Pro Thr Glu Thr Asp Thr Tyr Ala Cys Arg Val Lys His 
        115                 120                 125             


Ala Ser Met Ala Glu Pro Lys Thr Val Tyr Trp Asp Arg Asp Met Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
145                 150                 155                 160 


Gly Gly Ser Gly Gly Gly Gly Ser Asp Pro Ala Gly Leu Leu Asp Leu 
                165                 170                 175     


Arg Gln Gly Met Phe Ala Gln Leu Val Ala Gln Asn Val Leu Leu Ile 
            180                 185                 190         


Asp Gly Pro Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala Gly Val Ser 
        195                 200                 205             


Leu Thr Gly Gly Leu Ser Tyr Ala Glu Asp Thr Lys Glu Leu Val Val 
    210                 215                 220                 


Ala Lys Ala Gly Val Tyr Tyr Val Phe Phe Gln Leu Glu Leu Arg Arg 
225                 230                 235                 240 


Val Val Ala Gly Glu Gly Ser Gly Ser Val Ser Leu Ala Leu His Leu 
                245                 250                 255     


Gln Pro Leu Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala Leu Thr Val 
            260                 265                 270         


Asp Leu Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala Phe Gly Phe 
        275                 280                 285             


Gln Gly Arg Leu Leu His Leu Ser Ala Gly Gln Arg Leu Gly Val His 
    290                 295                 300                 


Leu His Thr Glu Ala Arg Ala Arg His Ala Trp Gln Leu Thr Gln Gly 
305                 310                 315                 320 


Ala Thr Val Leu Gly Leu Phe Arg Val Thr Pro Glu Ile Pro Ala Gly 
                325                 330                 335     


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            340                 345                 350         


Gly Gly Ser Gly Gly Gly Gly Ser Asp Pro Ala Gly Leu Leu Asp Leu 
        355                 360                 365             


Arg Gln Gly Met Phe Ala Gln Leu Val Ala Gln Asn Val Leu Leu Ile 
    370                 375                 380                 


Asp Gly Pro Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala Gly Val Ser 
385                 390                 395                 400 


Leu Thr Gly Gly Leu Ser Tyr Ala Glu Asp Thr Lys Glu Leu Val Val 
                405                 410                 415     


Ala Lys Ala Gly Val Tyr Tyr Val Phe Phe Gln Leu Glu Leu Arg Arg 
            420                 425                 430         


Val Val Ala Gly Glu Gly Ser Gly Ser Val Ser Leu Ala Leu His Leu 
        435                 440                 445             


Gln Pro Leu Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala Leu Thr Val 
    450                 455                 460                 


Asp Leu Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala Phe Gly Phe 
465                 470                 475                 480 


Gln Gly Arg Leu Leu His Leu Ser Ala Gly Gln Arg Leu Gly Val His 
                485                 490                 495     


Leu His Thr Glu Ala Arg Ala Arg His Ala Trp Gln Leu Thr Gln Gly 
            500                 505                 510         


Ala Thr Val Leu Gly Leu Phe Arg Val Thr Pro Glu Ile Pro Ala Gly 
        515                 520                 525             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    530                 535                 540                 


Gly Gly Ser Gly Gly Gly Gly Ser Asp Pro Ala Gly Leu Leu Asp Leu 
545                 550                 555                 560 


Arg Gln Gly Met Phe Ala Gln Leu Val Ala Gln Asn Val Leu Leu Ile 
                565                 570                 575     


Asp Gly Pro Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala Gly Val Ser 
            580                 585                 590         


Leu Thr Gly Gly Leu Ser Tyr Lys Glu Asp Thr Lys Glu Leu Val Val 
        595                 600                 605             


Ala Lys Ala Gly Val Tyr Tyr Val Phe Phe Gln Leu Glu Leu Arg Arg 
    610                 615                 620                 


Val Val Ala Gly Glu Gly Ser Gly Ser Val Ser Leu Ala Leu His Leu 
625                 630                 635                 640 


Gln Pro Leu Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala Leu Thr Val 
                645                 650                 655     


Asp Leu Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala Phe Gly Phe 
            660                 665                 670         


Gln Gly Arg Leu Leu His Leu Ser Ala Gly Gln Arg Leu Gly Val His 
        675                 680                 685             


Leu His Thr Glu Ala Arg Ala Arg His Ala Trp Gln Leu Thr Gln Gly 
    690                 695                 700                 


Ala Thr Val Leu Gly Leu Phe Arg Val Thr Pro Glu Ile Pro Ala Ser 
705                 710                 715                 720 


