                         SEQUENCE LISTING

<110>  Albert Einstein College of Medicine, Inc.
 
<120>  ENGINEERED PD-1 VARIANTS

<130>  96700/2497

<150>  US 62/337,388
<151>  2016-05-17

<160>  37    

<170>  PatentIn version 3.5

<210>  1
<211>  129
<212>  PRT
<213>  Homo sapiens

<400>  1

Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly 
1               5                   10                  15      


Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe 
            20                  25                  30          


Val Leu Asn Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu 
        35                  40                  45              


Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe 
    50                  55                  60                  


Arg Val Thr Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val 
65                  70                  75                  80  


Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser 
                85                  90                  95      


Leu Ala Pro Lys Ala Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg 
            100                 105                 110         


Val Thr Glu Arg Arg Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser 
        115                 120                 125             


Pro 
    


<210>  2
<211>  129
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  based on human PD-1


<220>
<221>  MISC_FEATURE
<222>  (31)..(31)
<223>  X = S or A

<220>
<221>  MISC_FEATURE
<222>  (33)..(33)
<223>  X = V or I

<220>
<221>  MISC_FEATURE
<222>  (39)..(39)
<223>  X = l or M

<220>
<221>  MISC_FEATURE
<222>  (41)..(41)
<223>  X = P or A

<220>
<221>  MISC_FEATURE
<222>  (91)..(91)
<223>  X = L or I

<220>
<221>  MISC_FEATURE
<222>  (96)..(96)
<223>  X = A or S

<220>
<221>  MISC_FEATURE
<222>  (97)..(97)
<223>  X = L or I

<220>
<221>  MISC_FEATURE
<222>  (98)..(98)
<223>  X = A or S

<220>
<221>  MISC_FEATURE
<222>  (100)..(100)
<223>  X = R or K

<220>
<221>  MISC_FEATURE
<222>  (101)..(101)
<223>  X = A or S

<220>
<221>  MISC_FEATURE
<222>  (103)..(103)
<223>  X = I or V

<400>  2

Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly 
1               5                   10                  15      


Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Xaa Phe 
            20                  25                  30          


Xaa Leu Asn Trp Tyr Arg Xaa Ser Xaa Ser Asn Gln Thr Asp Lys Leu 
        35                  40                  45              


Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe 
    50                  55                  60                  


Arg Val Thr Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val 
65                  70                  75                  80  


Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr Xaa Cys Ala Ala Ile Xaa 
                85                  90                  95      


Xaa Xaa Pro Xaa Xaa Gln Xaa Lys Glu Ser Leu Arg Ala Glu Leu Arg 
            100                 105                 110         


Val Thr Glu Arg Arg Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser 
        115                 120                 125             


Pro 
    


<210>  3
<211>  129
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  based on human PD-1


<220>
<221>  MISC_FEATURE
<222>  (31)..(31)
<223>  X = S or A

<220>
<221>  MISC_FEATURE
<222>  (33)..(33)
<223>  X = V or I

<220>
<221>  MISC_FEATURE
<222>  (39)..(39)
<223>  X = L or M

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  X = S or A

<220>
<221>  MISC_FEATURE
<222>  (41)..(41)
<223>  X = P or A

<220>
<221>  MISC_FEATURE
<222>  (42)..(42)
<223>  X = S or A

<220>
<221>  MISC_FEATURE
<222>  (43)..(43)
<223>  X = N or D

<220>
<221>  MISC_FEATURE
<222>  (58)..(58)
<223>  X =P or S

<220>
<221>  MISC_FEATURE
<222>  (91)..(91)
<223>  X =L or I

<220>
<221>  MISC_FEATURE
<222>  (95)..(95)
<223>  X =I or V

<220>
<221>  MISC_FEATURE
<222>  (96)..(96)
<223>  X =A or S

<220>
<221>  MISC_FEATURE
<222>  (97)..(97)
<223>  X =L or I

<220>
<221>  MISC_FEATURE
<222>  (98)..(98)
<223>  X =A or S

<220>
<221>  MISC_FEATURE
<222>  (99)..(99)
<223>  X = P or A

<220>
<221>  MISC_FEATURE
<222>  (100)..(100)
<223>  X = R or K

<220>
<221>  MISC_FEATURE
<222>  (101)..(101)
<223>  X = A or S

<220>
<221>  MISC_FEATURE
<222>  (103)..(103)
<223>  X = I or V

<400>  3

Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly 
1               5                   10                  15      


Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Xaa Phe 
            20                  25                  30          


Xaa Leu Asn Trp Tyr Arg Xaa Xaa Xaa Xaa Xaa Gln Thr Asp Lys Leu 
        35                  40                  45              


Ala Ala Phe Pro Glu Asp Arg Ser Gln Xaa Gly Gln Asp Cys Arg Phe 
    50                  55                  60                  


Arg Val Thr Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val 
65                  70                  75                  80  


Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr Xaa Cys Ala Ala Xaa Xaa 
                85                  90                  95      


Xaa Xaa Xaa Xaa Xaa Gln Xaa Lys Glu Ser Leu Arg Ala Glu Leu Arg 
            100                 105                 110         


Val Thr Glu Arg Arg Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser 
        115                 120                 125             


Pro 
    


<210>  4
<211>  129
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  based on human PD-1

<400>  4

Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly 
1               5                   10                  15      


Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe 
            20                  25                  30          


Val Leu Asn Trp Tyr Arg Leu Ser Pro Ser Asn Gln Thr Asp Lys Leu 
        35                  40                  45              


Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe 
    50                  55                  60                  


Arg Val Thr Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val 
65                  70                  75                  80  


Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr Leu Cys Ala Ala Ile Ala 
                85                  90                  95      


Leu Ser Pro Arg Ala Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg 
            100                 105                 110         


Val Thr Glu Arg Arg Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser 
        115                 120                 125             


Pro 
    


<210>  5
<211>  129
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  based on human PD-1

<400>  5

Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly 
1               5                   10                  15      


Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe 
            20                  25                  30          


Ile Leu Asn Trp Tyr Arg Leu Ser Pro Ser Asn Gln Thr Asp Lys Leu 
        35                  40                  45              


Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe 
    50                  55                  60                  


Arg Val Thr Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val 
65                  70                  75                  80  


Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr Leu Cys Ala Ala Ile Ala 
                85                  90                  95      


Leu Ala Pro Ser Ser Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg 
            100                 105                 110         


Val Thr Glu Arg Arg Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser 
        115                 120                 125             


Pro 
    


<210>  6
<211>  129
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  based on human PD-1

<400>  6

Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly 
1               5                   10                  15      


Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe 
            20                  25                  30          


Val Leu Asn Trp Tyr Arg Leu Ser Pro Ser Asn Gln Thr Asp Lys Leu 
        35                  40                  45              


Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe 
    50                  55                  60                  


Arg Val Thr Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val 
65                  70                  75                  80  


Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr Leu Cys Ala Ala Ile Ala 
                85                  90                  95      


Leu Ser Pro Lys Ala Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg 
            100                 105                 110         


Val Thr Glu Arg Arg Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser 
        115                 120                 125             


Pro 
    


<210>  7
<211>  130
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  based on human PD-1

<400>  7

Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly 
1               5                   10                  15      


Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe 
            20                  25                  30          


Ile Leu Asn Trp Tyr Arg Leu Ser Pro Ser Asn Gln Thr Asp Lys Leu 
        35                  40                  45              


Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe 
    50                  55                  60                  


Arg Val Thr Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val 
65                  70                  75                  80  


Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr Ile Ala Gly Ala Ile Ala 
                85                  90                  95      


Leu Ser Pro Glx Arg Ala Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu 
            100                 105                 110         


Arg Val Thr Glu Arg Arg Ala Glu Val Pro Thr Ala His Pro Ser Pro 
        115                 120                 125             


Ser Pro 
    130 


<210>  8
<211>  129
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  based on human PD-1

<400>  8

Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly 
1               5                   10                  15      


Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe 
            20                  25                  30          


Val Leu Asn Trp Tyr Arg Leu Ser Pro Ser Asn Gln Thr Asp Lys Leu 
        35                  40                  45              


Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe 
    50                  55                  60                  


Arg Val Thr Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val 
65                  70                  75                  80  


Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr Leu Cys Ala Ala Ile Ser 
                85                  90                  95      


Leu Ser Pro Arg Ala Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg 
            100                 105                 110         


Val Thr Glu Arg Arg Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser 
        115                 120                 125             


Pro 
    


<210>  9
<211>  129
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  based on human PD-1

<400>  9

Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly 
1               5                   10                  15      


Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ala Phe 
            20                  25                  30          


Ile Leu Asn Trp Tyr Arg Leu Ser Pro Ser Asn Gln Thr Asp Lys Leu 
        35                  40                  45              


Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe 
    50                  55                  60                  


Arg Val Thr Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val 
65                  70                  75                  80  


Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr Ile Cys Ala Ala Ile Ser 
                85                  90                  95      


Ile Ala Pro Arg Ala Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg 
            100                 105                 110         


Val Thr Glu Arg Arg Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser 
        115                 120                 125             


Pro 
    


<210>  10
<211>  129
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  based on humna PD-1

<400>  10

Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly 
1               5                   10                  15      


Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe 
            20                  25                  30          


Ile Leu Asn Trp Tyr Arg Leu Ser Ala Ser Asn Gln Thr Asp Lys Leu 
        35                  40                  45              


Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe 
    50                  55                  60                  


Arg Val Thr Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val 
65                  70                  75                  80  


Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr Ile Cys Ala Ala Ile Ser 
                85                  90                  95      


Ile Ala Pro Arg Ala Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg 
            100                 105                 110         


Val Thr Glu Arg Arg Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser 
        115                 120                 125             


Pro 
    


<210>  11
<211>  129
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  based on human PD-1

<400>  11

Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly 
1               5                   10                  15      


Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ala Phe 
            20                  25                  30          


Ile Leu Asn Trp Tyr Arg Leu Ser Pro Ser Asn Gln Thr Asp Lys Leu 
        35                  40                  45              


Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe 
    50                  55                  60                  


Arg Val Thr Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val 
65                  70                  75                  80  


Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr Ile Cys Ala Ala Ile Ser 
                85                  90                  95      


Leu Ser Pro Arg Ala Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg 
            100                 105                 110         


Val Thr Glu Arg Arg Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser 
        115                 120                 125             


Pro 
    


<210>  12
<211>  129
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  based on human PD-1

<400>  12

Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly 
1               5                   10                  15      


Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ala Phe 
            20                  25                  30          


Val Leu Asn Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu 
        35                  40                  45              


Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe 
    50                  55                  60                  


Arg Val Thr Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val 
65                  70                  75                  80  


Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr Ile Cys Ala Ala Ile Ser 
                85                  90                  95      


Leu Ser Pro Lys Ala Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg 
            100                 105                 110         


Val Thr Glu Arg Arg Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser 
        115                 120                 125             


Pro 
    


<210>  13
<211>  129
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  based on human PD-1

<400>  13

Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly 
1               5                   10                  15      


Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe 
            20                  25                  30          


Val Leu Asn Trp Tyr Arg Leu Ser Pro Ser Asn Gln Thr Asp Lys Leu 
        35                  40                  45              


Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe 
    50                  55                  60                  


Arg Val Thr Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val 
65                  70                  75                  80  


Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr Ile Cys Ala Ala Ile Ala 
                85                  90                  95      


Leu Ser Pro Arg Ala Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg 
            100                 105                 110         


Val Thr Glu Arg Arg Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser 
        115                 120                 125             


Pro 
    


<210>  14
<211>  129
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  based on human PD-1

<400>  14

Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly 
1               5                   10                  15      


Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe 
            20                  25                  30          


Ile Leu Asn Trp Tyr Arg Leu Ser Pro Ser Asn Gln Thr Asp Lys Leu 
        35                  40                  45              


Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe 
    50                  55                  60                  


Arg Val Thr Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val 
65                  70                  75                  80  


Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr Ile Cys Ala Ala Ile Ser 
                85                  90                  95      


Leu Ser Pro Lys Ala Gln Val Lys Glu Ser Leu Arg Ala Glu Leu Arg 
            100                 105                 110         


Val Thr Glu Arg Arg Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser 
        115                 120                 125             


Pro 
    


<210>  15
<211>  129
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  based on human PD-1

<400>  15

Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly 
1               5                   10                  15      


Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe 
            20                  25                  30          


Ile Leu Asn Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu 
        35                  40                  45              


Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe 
    50                  55                  60                  


Arg Val Thr Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val 
65                  70                  75                  80  


Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr Ile Cys Ala Ala Ile Ser 
                85                  90                  95      


Leu Ala Pro Lys Ser Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg 
            100                 105                 110         


Val Thr Glu Arg Arg Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser 
        115                 120                 125             


Pro 
    


<210>  16
<211>  129
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  based on human PD-1

<400>  16

Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly 
1               5                   10                  15      


Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe 
            20                  25                  30          


Val Leu Asn Trp Tyr Arg Met Ser Ala Ser Asn Gln Thr Asp Lys Leu 
        35                  40                  45              


Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe 
    50                  55                  60                  


Arg Val Thr Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val 
65                  70                  75                  80  


Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr Ile Cys Ala Ala Ile Ser 
                85                  90                  95      


Leu Ser Pro Arg Ala Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg 
            100                 105                 110         


Val Thr Glu Arg Arg Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser 
        115                 120                 125             


Pro 
    


<210>  17
<211>  129
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  based on human PD-1

<400>  17

Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly 
1               5                   10                  15      


Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe 
            20                  25                  30          


Ile Leu Asn Trp Tyr Arg Leu Ser Pro Ser Asn Gln Thr Asp Lys Leu 
        35                  40                  45              


Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe 
    50                  55                  60                  


Arg Val Thr Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val 
65                  70                  75                  80  


Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr Ile Cys Ala Ala Ile Ala 
                85                  90                  95      


Leu Ser Pro Lys Ala Gln Val Lys Glu Ser Leu Arg Ala Glu Leu Arg 
            100                 105                 110         


Val Thr Glu Arg Arg Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser 
        115                 120                 125             


Pro 
    


<210>  18
<211>  129
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  based on human PD-1

<400>  18

Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly 
1               5                   10                  15      


Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe 
            20                  25                  30          


Ile Leu Asn Trp Tyr Arg Leu Ser Pro Ser Asn Gln Thr Asp Lys Leu 
        35                  40                  45              


Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe 
    50                  55                  60                  


Arg Val Thr Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val 
65                  70                  75                  80  


Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr Leu Cys Ala Ala Val Ala 
                85                  90                  95      


Leu Ala Pro Arg Ala Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg 
            100                 105                 110         


Val Thr Glu Arg Arg Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser 
        115                 120                 125             


Pro 
    


<210>  19
<211>  129
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  based on human PD-1

<400>  19

Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly 
1               5                   10                  15      


Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ala Phe 
            20                  25                  30          


Val Leu Asn Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu 
        35                  40                  45              


Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe 
    50                  55                  60                  


Arg Val Thr Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val 
65                  70                  75                  80  


Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr Leu Cys Ala Ala Ile Ala 
                85                  90                  95      


Ile Ser Pro Lys Ser Gln Val Lys Glu Ser Leu Arg Ala Glu Leu Arg 
            100                 105                 110         


Val Thr Glu Arg Arg Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser 
        115                 120                 125             


Pro 
    


<210>  20
<211>  129
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  based on human PD-1

<400>  20

Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly 
1               5                   10                  15      


Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ala Phe 
            20                  25                  30          


Val Leu Asn Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu 
        35                  40                  45              


Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe 
    50                  55                  60                  


Arg Val Thr Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val 
65                  70                  75                  80  


Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr Leu Cys Ala Ala Ile Ser 
                85                  90                  95      


Leu Ser Pro Arg Ser Gln Val Lys Glu Ser Leu Arg Ala Glu Leu Arg 
            100                 105                 110         


Val Thr Glu Arg Arg Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser 
        115                 120                 125             


Pro 
    


<210>  21
<211>  129
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  based on human PD-1

<400>  21

Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly 
1               5                   10                  15      


Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe 
            20                  25                  30          


Ile Leu Asn Trp Tyr Arg Leu Ser Pro Ser Asn Gln Thr Asp Lys Leu 
        35                  40                  45              


Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe 
    50                  55                  60                  


Arg Val Thr Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val 
65                  70                  75                  80  


Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr Leu Cys Ala Ala Val Ser 
                85                  90                  95      


Ile Ser Pro Arg Ser Gln Val Lys Glu Ser Leu Arg Ala Glu Leu Arg 
            100                 105                 110         


Val Thr Glu Arg Arg Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser 
        115                 120                 125             


Pro 
    


<210>  22
<211>  129
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  based on human PD-1

<400>  22

Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly 
1               5                   10                  15      


Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe 
            20                  25                  30          


Ile Leu Asn Trp Tyr Arg Leu Ser Ala Ser Asn Gln Thr Asp Lys Leu 
        35                  40                  45              


Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe 
    50                  55                  60                  


Arg Val Thr Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val 
65                  70                  75                  80  


Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser 
                85                  90                  95      


Leu Ala Pro Lys Ala Gln Val Lys Glu Ser Leu Arg Ala Glu Leu Arg 
            100                 105                 110         


Val Thr Glu Arg Arg Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser 
        115                 120                 125             


Pro 
    


<210>  23
<211>  129
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  based on human PD-1

<400>  23

Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly 
1               5                   10                  15      


Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe 
            20                  25                  30          


Ile Leu Asn Trp Tyr Arg Leu Ser Pro Ser Asn Gln Thr Asp Lys Leu 
        35                  40                  45              


Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe 
    50                  55                  60                  


Arg Val Thr Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val 
65                  70                  75                  80  


Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr Leu Cys Ala Ala Ile Ser 
                85                  90                  95      


Leu Ser Pro Lys Ser Gln Val Lys Glu Ser Leu Arg Ala Glu Leu Arg 
            100                 105                 110         


Val Thr Glu Arg Arg Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser 
        115                 120                 125             


Pro 
    


<210>  24
<211>  129
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  based on human PD-1

<400>  24

Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly 
1               5                   10                  15      


Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ala Phe 
            20                  25                  30          


Ile Leu Asn Trp Tyr Arg Met Ser Ala Ser Asn Gln Thr Asp Lys Leu 
        35                  40                  45              


Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe 
    50                  55                  60                  


Arg Val Thr Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val 
65                  70                  75                  80  


Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr Leu Cys Ala Ala Val Ser 
                85                  90                  95      


Leu Ser Ala Lys Ser Gln Val Lys Glu Ser Leu Arg Ala Glu Leu Arg 
            100                 105                 110         


Val Thr Glu Arg Arg Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser 
        115                 120                 125             


Pro 
    


<210>  25
<211>  129
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  based on human PD-1

<400>  25

Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly 
1               5                   10                  15      


Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe 
            20                  25                  30          


Val Leu Asn Trp Tyr Arg Leu Ser Ala Ser Asn Gln Thr Asp Lys Leu 
        35                  40                  45              


Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe 
    50                  55                  60                  


Arg Val Thr Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val 
65                  70                  75                  80  


Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr Leu Cys Ala Ala Val Ser 
                85                  90                  95      


Leu Ser Ala Lys Ser Gln Val Lys Glu Ser Leu Arg Ala Glu Leu Arg 
            100                 105                 110         


Val Thr Glu Arg Arg Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser 
        115                 120                 125             


Pro 
    


<210>  26
<211>  129
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  based on human PD-1

<400>  26

Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly 
1               5                   10                  15      


Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe 
            20                  25                  30          


Ile Leu Asn Trp Tyr Arg Leu Ser Ala Ala Asn Gln Thr Asp Lys Leu 
        35                  40                  45              


Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe 
    50                  55                  60                  


Arg Val Thr Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val 
65                  70                  75                  80  


Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr Leu Cys Ala Ala Val Ser 
                85                  90                  95      


Leu Ser Pro Lys Ala Gln Val Lys Glu Ser Leu Arg Ala Glu Leu Arg 
            100                 105                 110         


Val Thr Glu Arg Arg Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser 
        115                 120                 125             


Pro 
    


<210>  27
<211>  129
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  based on human PD-1

<400>  27

Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly 
1               5                   10                  15      


Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe 
            20                  25                  30          


Ile Leu Asn Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu 
        35                  40                  45              


Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe 
    50                  55                  60                  


Arg Val Thr Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val 
65                  70                  75                  80  


Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr Leu Cys Ala Ala Val Ala 
                85                  90                  95      


Ile Ala Pro Arg Ser Gln Val Lys Glu Ser Leu Arg Ala Glu Leu Arg 
            100                 105                 110         


Val Thr Glu Arg Arg Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser 
        115                 120                 125             


Pro 
    


<210>  28
<211>  128
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  based on human PD-1

<400>  28

Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly 
1               5                   10                  15      


Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ala Phe 
            20                  25                  30          


Ile Leu Asn Trp Tyr Arg Leu Ser Pro Ser Asn Gln Thr Asp Lys Leu 
        35                  40                  45              


Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe 
    50                  55                  60                  


Arg Val Thr Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val 
65                  70                  75                  80  


Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr Leu Cys Ala Ala Ser Leu 
                85                  90                  95      


Ser Pro Arg Ala Gln Val Lys Glu Ser Leu Arg Ala Glu Leu Arg Val 
            100                 105                 110         


Thr Glu Arg Arg Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro 
        115                 120                 125             


<210>  29
<211>  129
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  based on human PD-1

<400>  29

Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly 
1               5                   10                  15      


Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ala Phe 
            20                  25                  30          


Ile Leu Asn Trp Tyr Arg Met Ser Pro Ser Asp Gln Thr Asp Lys Leu 
        35                  40                  45              


Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe 
    50                  55                  60                  


Arg Val Thr Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val 
65                  70                  75                  80  


Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr Leu Cys Ala Ala Ile Ser 
                85                  90                  95      


Leu Ser Ala Lys Ser Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg 
            100                 105                 110         


Val Thr Glu Arg Arg Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser 
        115                 120                 125             


Pro 
    


<210>  30
<211>  129
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  based on human PD-1

<400>  30

Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly 
1               5                   10                  15      


Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe 
            20                  25                  30          


Ile Leu Asn Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu 
        35                  40                  45              


Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe 
    50                  55                  60                  


Arg Val Thr Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val 
65                  70                  75                  80  


Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr Leu Cys Ala Ala Val Ala 
                85                  90                  95      


Ile Ala Pro Arg Ala Gln Val Lys Glu Ser Leu Arg Ala Glu Leu Arg 
            100                 105                 110         


Val Thr Glu Arg Arg Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser 
        115                 120                 125             


Pro 
    


<210>  31
<211>  129
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  based on human PD-1

<400>  31

Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly 
1               5                   10                  15      


Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe 
            20                  25                  30          


Ile Leu Asn Trp Tyr Arg Leu Ser Pro Ala Asn Gln Thr Asp Lys Leu 
        35                  40                  45              


Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe 
    50                  55                  60                  


Arg Val Thr Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val 
65                  70                  75                  80  


Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr Leu Cys Ala Ala Val Ser 
                85                  90                  95      


Leu Ala Ala Lys Ala Gln Val Lys Glu Ser Leu Arg Ala Glu Leu Arg 
            100                 105                 110         


Val Thr Glu Arg Arg Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser 
        115                 120                 125             


Pro 
    


<210>  32
<211>  129
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  based on human PD-1

<400>  32

Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly 
1               5                   10                  15      


Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe 
            20                  25                  30          


Ile Leu Asn Trp Tyr Arg Met Ser Ala Ser Asp Gln Thr Asp Lys Leu 
        35                  40                  45              


Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe 
    50                  55                  60                  


Arg Val Thr Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val 
65                  70                  75                  80  


Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr Leu Cys Ala Ala Ile Ala 
                85                  90                  95      


Leu Ser Ala Lys Ala Gln Val Lys Glu Ser Leu Arg Ala Glu Leu Arg 
            100                 105                 110         


Val Thr Glu Arg Arg Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser 
        115                 120                 125             


Pro 
    


<210>  33
<211>  129
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  based on human PD-1

<400>  33

Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly 
1               5                   10                  15      


Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ala Phe 
            20                  25                  30          


Ile Leu Asn Trp Tyr Arg Leu Ser Pro Ser Asn Gln Thr Asp Lys Leu 
        35                  40                  45              


Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe 
    50                  55                  60                  


Arg Val Thr Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val 
65                  70                  75                  80  


Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr Leu Cys Ala Ala Ile Ser 
                85                  90                  95      


Leu Ser Ala Lys Ser Gln Val Lys Glu Ser Leu Arg Ala Glu Leu Arg 
            100                 105                 110         


Val Thr Glu Arg Arg Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser 
        115                 120                 125             


Pro 
    


<210>  34
<211>  129
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  based on human PD-1

<400>  34

Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly 
1               5                   10                  15      


Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ala Phe 
            20                  25                  30          


Ile Leu Asn Trp Tyr Arg Leu Ser Pro Ser Asn Gln Thr Asp Lys Leu 
        35                  40                  45              


Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe 
    50                  55                  60                  


Arg Val Thr Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val 
65                  70                  75                  80  


Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr Leu Cys Ala Ala Val Ser 
                85                  90                  95      


Leu Ser Pro Lys Ala Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg 
            100                 105                 110         


Val Thr Glu Arg Arg Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser 
        115                 120                 125             


Pro 
    


<210>  35
<211>  129
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  based on human PD-1

<400>  35

Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly 
1               5                   10                  15      


Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe 
            20                  25                  30          


Ile Leu Asn Trp Tyr Arg Leu Ser Ala Ser Asn Gln Thr Asp Lys Leu 
        35                  40                  45              


Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe 
    50                  55                  60                  


Arg Val Thr Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val 
65                  70                  75                  80  


Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr Ile Cys Ala Ala Ile Ser 
                85                  90                  95      


Leu Ser Ala Arg Ser Gln Val Lys Glu Ser Leu Arg Ala Glu Leu Arg 
            100                 105                 110         


Val Thr Glu Arg Arg Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser 
        115                 120                 125             


Pro 
    


<210>  36
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  based on human PD-1

<400>  36

Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly 
1               5                   10                  15      


Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ala Phe 
            20                  25                  30          


Ile Leu Asn Trp Tyr Arg Leu Ser Ala Ser Asn Gln Thr Asp Lys Leu 
        35                  40                  45              


Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe 
    50                  55                  60                  


Arg Val Thr Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val 
65                  70                  75                  80  


Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr Leu Cys Ala Ala Ile Ala 
                85                  90                  95      


Lys Ala Gln Val Lys Glu Ser Leu Arg Ala Glu Leu Arg Val Thr Glu 
            100                 105                 110         


Arg Arg Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro 
        115                 120                 125     


<210>  37
<211>  129
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  based on human PD-1

<400>  37

Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly 
1               5                   10                  15      


Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe 
            20                  25                  30          


Ile Leu Asn Trp Tyr Arg Leu Ser Ala Ser Asn Gln Thr Asp Lys Leu 
        35                  40                  45              


Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe 
    50                  55                  60                  


Arg Val Thr Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val 
65                  70                  75                  80  


Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr Leu Cys Ala Ala Ile Ala 
                85                  90                  95      


Ile Ser Ala Arg Ser Gln Val Lys Glu Ser Leu Arg Ala Glu Leu Arg 
            100                 105                 110         


Val Thr Glu Arg Arg Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser 
        115                 120                 125             


Pro 
    


