                         SEQUENCE LISTING

<110>  Oxford University Innovation Limited
 
<120>  Vaccines

<130>  489.412.126519/02

<160>  53    

<170>  PatentIn version 3.5

<210>  1
<211>  378
<212>  PRT
<213>  Plasmodium vivax

<400>  1

Met Lys Asn Phe Ile Leu Leu Ala Val Ser Ser Ile Leu Leu Val Asp 
1               5                   10                  15      


Leu Phe Pro Thr His Cys Gly His Asn Val Asp Leu Ser Lys Ala Ile 
            20                  25                  30          


Asn Leu Asn Gly Val Asn Phe Asn Asn Val Asp Ala Ser Ser Leu Gly 
        35                  40                  45              


Ala Ala His Val Gly Gln Ser Ala Ser Arg Gly Arg Gly Leu Gly Glu 
    50                  55                  60                  


Asn Pro Asp Asp Glu Glu Gly Asp Ala Lys Lys Lys Lys Asp Gly Lys 
65                  70                  75                  80  


Lys Ala Glu Pro Lys Asn Pro Arg Glu Asn Lys Leu Lys Gln Pro Gly 
                85                  90                  95      


Asp Arg Ala Asp Gly Gln Pro Ala Gly Asp Arg Ala Asp Gly Gln Pro 
            100                 105                 110         


Ala Gly Asp Arg Ala Asp Gly Gln Pro Ala Gly Asp Arg Ala Ala Gly 
        115                 120                 125             


Gln Pro Ala Gly Asp Arg Ala Asp Gly Gln Pro Ala Gly Asp Arg Ala 
    130                 135                 140                 


Asp Gly Gln Pro Ala Gly Asp Arg Ala Asp Gly Gln Pro Ala Gly Asp 
145                 150                 155                 160 


Arg Ala Asp Gly Gln Pro Ala Gly Asp Arg Ala Ala Gly Gln Pro Ala 
                165                 170                 175     


Gly Asp Arg Ala Ala Gly Gln Pro Ala Gly Asp Arg Ala Asp Gly Gln 
            180                 185                 190         


Pro Ala Gly Asp Arg Ala Ala Gly Gln Pro Ala Gly Asp Arg Ala Asp 
        195                 200                 205             


Gly Gln Pro Ala Gly Asp Arg Ala Ala Gly Gln Pro Ala Gly Asp Arg 
    210                 215                 220                 


Ala Asp Gly Gln Pro Ala Gly Asp Arg Ala Ala Gly Gln Pro Ala Gly 
225                 230                 235                 240 


Asp Arg Ala Ala Gly Gln Pro Ala Gly Asp Arg Ala Ala Gly Gln Pro 
                245                 250                 255     


Ala Gly Asp Arg Ala Ala Gly Gln Pro Ala Gly Asn Gly Ala Gly Gly 
            260                 265                 270         


Gln Ala Ala Gly Gly Asn Ala Gly Gly Gly Gln Gly Gln Asn Asn Glu 
        275                 280                 285             


Gly Ala Asn Ala Pro Asn Glu Lys Ser Val Lys Glu Tyr Leu Asp Lys 
    290                 295                 300                 


Val Arg Ala Thr Val Gly Thr Glu Trp Thr Pro Cys Ser Val Thr Cys 
305                 310                 315                 320 


Gly Val Gly Val Arg Val Arg Arg Arg Val Asn Ala Ala Asn Lys Lys 
                325                 330                 335     


Pro Glu Asp Leu Thr Leu Asn Asp Leu Glu Thr Asp Val Cys Thr Met 
            340                 345                 350         


Asp Lys Cys Ala Gly Ile Phe Asn Val Val Ser Asn Ser Leu Gly Leu 
        355                 360                 365             


Val Ile Leu Leu Val Leu Ala Leu Phe Asn 
    370                 375             


<210>  2
<211>  395
<212>  PRT
<213>  Plasmodium vivax

<400>  2

Met Lys Asn Phe Ile Leu Leu Ala Val Ser Ser Ile Leu Leu Val Asp 
1               5                   10                  15      


Leu Phe Pro Thr His Cys Gly His Asn Val Asp Leu Ser Lys Ala Ile 
            20                  25                  30          


Asn Leu Asn Gly Val Gly Phe Asn Asn Val Asp Ala Ser Ser Leu Gly 
        35                  40                  45              


Ala Ala His Val Gly Gln Ser Ala Ser Arg Gly Arg Gly Leu Gly Glu 
    50                  55                  60                  


Asn Pro Asp Asp Glu Glu Gly Asp Ala Lys Lys Lys Lys Asp Gly Lys 
65                  70                  75                  80  


Lys Ala Glu Pro Lys Asn Pro Arg Glu Asn Lys Leu Lys Gln Pro Glu 
                85                  90                  95      


Asp Gly Ala Gly Asn Gln Pro Gly Ala Asn Gly Ala Gly Asn Gln Pro 
            100                 105                 110         


Gly Ala Asn Gly Ala Gly Asn Gln Pro Gly Ala Asn Gly Ala Gly Asp 
        115                 120                 125             


Gln Pro Gly Ala Asn Gly Ala Gly Asn Gln Pro Gly Ala Asn Gly Ala 
    130                 135                 140                 


Gly Asp Gln Pro Gly Ala Asn Gly Ala Gly Asn Gln Pro Gly Ala Asn 
145                 150                 155                 160 


Gly Ala Gly Asn Gln Pro Gly Ala Asn Gly Ala Gly Asn Gln Pro Gly 
                165                 170                 175     


Ala Asn Gly Ala Asp Asp Gln Pro Gly Ala Asn Gly Ala Gly Asn Gln 
            180                 185                 190         


Pro Gly Ala Asn Gly Ala Gly Asn Gln Pro Gly Ala Asn Gly Ala Gly 
        195                 200                 205             


Asn Gln Pro Gly Ala Asn Gly Ala Gly Asp Gln Pro Gly Ala Asn Gly 
    210                 215                 220                 


Ala Gly Asn Gln Pro Gly Ala Asn Gly Ala Gly Asp Gln Pro Gly Ala 
225                 230                 235                 240 


Asn Gly Ala Gly Asn Gln Pro Gly Ala Asn Gly Ala Gly Asn Gln Pro 
                245                 250                 255     


Gly Ala Asn Gly Ala Gly Asn Gln Pro Gly Ala Asn Gly Ala Gly Asn 
            260                 265                 270         


Gln Pro Gly Ala Asn Gly Ala Gly Gly Gln Ala Ala Gly Gly Asn Ala 
        275                 280                 285             


Ala Asn Lys Lys Ala Gly Asp Ala Gly Ala Gly Gln Gly Gln Asn Asn 
    290                 295                 300                 


Glu Gly Ala Asn Ala Thr Asn Glu Lys Ser Val Lys Glu Tyr Leu Asp 
305                 310                 315                 320 


Lys Val Arg Ala Thr Val Gly Thr Glu Trp Thr Pro Cys Ser Val Thr 
                325                 330                 335     


Cys Gly Val Gly Val Arg Val Arg Arg Arg Val Asn Ala Ala Asn Lys 
            340                 345                 350         


Lys Pro Glu Asp Leu Thr Leu Asn Asp Leu Glu Thr Asp Val Cys Thr 
        355                 360                 365             


Met Asp Lys Cys Ala Gly Ile Phe Asn Val Val Ser Asn Ser Leu Gly 
    370                 375                 380                 


Leu Val Ile Leu Leu Val Leu Ala Leu Phe Asn 
385                 390                 395 


<210>  3
<211>  9
<212>  PRT
<213>  Plasmodium vivax

<400>  3

Gly Asp Arg Ala Ala Gly Gln Pro Ala 
1               5                   


<210>  4
<211>  9
<212>  PRT
<213>  Plasmodium vivax

<400>  4

Gly Asp Arg Ala Asp Gly Gln Pro Ala 
1               5                   


<210>  5
<211>  9
<212>  PRT
<213>  Plasmodium vivax

<400>  5

Gly Asn Gly Ala Gly Gly Gln Ala Ala 
1               5                   


<210>  6
<211>  9
<212>  PRT
<213>  Plasmodium vivax

<400>  6

Ala Asn Gly Ala Gly Asn Gln Pro Gly 
1               5                   


<210>  7
<211>  9
<212>  PRT
<213>  Plasmodium vivax

<400>  7

Ala Asn Gly Ala Gly Gly Gln Ala Ala 
1               5                   


<210>  8
<211>  9
<212>  PRT
<213>  Plasmodium vivax

<400>  8

Ala Asn Gly Ala Gly Asp Gln Pro Gly 
1               5                   


<210>  9
<211>  9
<212>  PRT
<213>  Plasmodium vivax

<400>  9

Ala Asn Gly Ala Asp Asp Gln Pro Gly 
1               5                   


<210>  10
<211>  9
<212>  PRT
<213>  Plasmodium vivax

<400>  10

Glu Asp Gly Ala Gly Asn Gln Pro Gly 
1               5                   


<210>  11
<211>  18
<212>  PRT
<213>  Plasmodium vivax

<400>  11

Ala Asn Gly Ala Gly Asn Gln Pro Gly Ala Asn Gly Ala Gly Gly Gln 
1               5                   10                  15      


Ala Ala 
        


<210>  12
<211>  18
<212>  PRT
<213>  Plasmodium vivax

<400>  12

Ala Asn Gly Ala Gly Asp Gln Pro Gly Ala Asn Gly Ala Gly Asp Gln 
1               5                   10                  15      


Pro Gly 
        


<210>  13
<211>  18
<212>  PRT
<213>  Plasmodium vivax

<400>  13

Ala Asn Gly Ala Asp Asp Gln Pro Gly Ala Asn Gly Ala Gly Asp Gln 
1               5                   10                  15      


Pro Gly 
        


<210>  14
<211>  18
<212>  PRT
<213>  Plasmodium vivax

<400>  14

Glu Asp Gly Ala Gly Asn Gln Pro Gly Ala Asn Gly Ala Gly Asp Gln 
1               5                   10                  15      


Pro Gly 
        


<210>  15
<211>  270
<212>  DNA
<213>  Plasmodium vivax

<400>  15
ggtgatagag ctgctggtca acctgctggt gacagagctg ctggacagcc agctggtgat       60

agagctgctg gtcagcctgc tggtgataga gctgctggac aacctgctgg tgatagagct      120

gctggtcaac ctgctggtga tagagctgac ggtcagccag ctggtgatag agctgacggt      180

caacctgctg gtgacagagc tgacggacaa cctgctggtg atagagctga tggacaacca      240

gctggaaatg gtgctggtgg tcaagctgct                                       270


<210>  16
<211>  90
<212>  PRT
<213>  Plasmodium vivax

<400>  16

Gly Asp Arg Ala Ala Gly Gln Pro Ala Gly Asp Arg Ala Ala Gly Gln 
1               5                   10                  15      


Pro Ala Gly Asp Arg Ala Ala Gly Gln Pro Ala Gly Asp Arg Ala Ala 
            20                  25                  30          


Gly Gln Pro Ala Gly Asp Arg Ala Ala Gly Gln Pro Ala Gly Asp Arg 
        35                  40                  45              


Ala Asp Gly Gln Pro Ala Gly Asp Arg Ala Asp Gly Gln Pro Ala Gly 
    50                  55                  60                  


Asp Arg Ala Asp Gly Gln Pro Ala Gly Asp Arg Ala Asp Gly Gln Pro 
65                  70                  75                  80  


Ala Gly Asn Gly Ala Gly Gly Gln Ala Ala 
                85                  90  


<210>  17
<211>  270
<212>  DNA
<213>  Plasmodium vivax

<400>  17
gctaatggtg ctggaaatca accaggtgct aacggtgctg gtggacaggc tgctgctaac       60

ggtgctggta accagcctgg tgctaatggt gctggtggac aagctgctgc taacggtgct      120

ggtgatcaac caggtgctaa tggtgctggt gatcagcctg gtgctaacgg tgctgatgac      180

caacctggtg ctaacggtgc tggtgaccag ccaggtgagg acggtgctgg taatcaacct      240

ggtgctaacg gtgctggtga tcaacctggt                                       270


<210>  18
<211>  90
<212>  PRT
<213>  Plasmodium vivax

<400>  18

Ala Asn Gly Ala Gly Asn Gln Pro Gly Ala Asn Gly Ala Gly Gly Gln 
1               5                   10                  15      


Ala Ala Ala Asn Gly Ala Gly Asn Gln Pro Gly Ala Asn Gly Ala Gly 
            20                  25                  30          


Gly Gln Ala Ala Ala Asn Gly Ala Gly Asp Gln Pro Gly Ala Asn Gly 
        35                  40                  45              


Ala Gly Asp Gln Pro Gly Ala Asn Gly Ala Asp Asp Gln Pro Gly Ala 
    50                  55                  60                  


Asn Gly Ala Gly Asp Gln Pro Gly Glu Asp Gly Ala Gly Asn Gln Pro 
65                  70                  75                  80  


Gly Ala Asn Gly Ala Gly Asp Gln Pro Gly 
                85                  90  


<210>  19
<211>  11
<212>  PRT
<213>  Plasmodium vivax


<220>
<221>  Xaa
<222>  (7)..(7)
<223>  Where Xaa can be glutamate/glutamic acid or glycine

<400>  19

Ala Pro Gly Ala Asn Gln Xaa Gly Gly Ala Ala 
1               5                   10      


<210>  20
<211>  11
<212>  PRT
<213>  Plasmodium vivax

<400>  20

Ala Pro Gly Ala Asn Gln Glu Gly Gly Ala Ala 
1               5                   10      


<210>  21
<211>  11
<212>  PRT
<213>  Plasmodium vivax

<400>  21

Ala Pro Gly Ala Asn Gln Gly Gly Gly Ala Ala 
1               5                   10      


<210>  22
<211>  99
<212>  DNA
<213>  Plasmodium vivax

<400>  22
gccccaggag caaatcagga aggtggagca gcagccccag gagcaaatca ggaaggtgga       60

gcagcagccc caggagcaaa tcaggaaggt ggagcagca                              99


<210>  23
<211>  33
<212>  PRT
<213>  Plasmodium vivax

<400>  23

Ala Pro Gly Ala Asn Gln Glu Gly Gly Ala Ala Ala Pro Gly Ala Asn 
1               5                   10                  15      


Gln Glu Gly Gly Ala Ala Ala Pro Gly Ala Asn Gln Glu Gly Gly Ala 
            20                  25                  30          


Ala 
    


<210>  24
<211>  99
<212>  DNA
<213>  Plasmodium vivax

<400>  24
gcaccaggag caaaccaggg aggtggagca gcagcaccag gagcaaacca gggaggtgga       60

gcagcagcac caggagcaaa ccagggaggt ggagcagca                              99


<210>  25
<211>  33
<212>  PRT
<213>  Plasmodium vivax

<400>  25

Ala Pro Gly Ala Asn Gln Gly Gly Gly Ala Ala Ala Pro Gly Ala Asn 
1               5                   10                  15      


Gln Gly Gly Gly Ala Ala Ala Pro Gly Ala Asn Gln Gly Gly Gly Ala 
            20                  25                  30          


Ala 
    


<210>  26
<211>  66
<212>  PRT
<213>  Plasmodium vivax

<400>  26

Ala Pro Gly Ala Asn Gln Glu Gly Gly Ala Ala Ala Pro Gly Ala Asn 
1               5                   10                  15      


Gln Glu Gly Gly Ala Ala Ala Pro Gly Ala Asn Gln Glu Gly Gly Ala 
            20                  25                  30          


Ala Ala Pro Gly Ala Asn Gln Gly Gly Gly Ala Ala Ala Pro Gly Ala 
        35                  40                  45              


Asn Gln Gly Gly Gly Ala Ala Ala Pro Gly Ala Asn Gln Gly Gly Gly 
    50                  55                  60                  


Ala Ala 
65      


<210>  27
<211>  66
<212>  PRT
<213>  Plasmodium vivax

<400>  27

Ala Pro Gly Ala Asn Gln Gly Gly Gly Ala Ala Ala Pro Gly Ala Asn 
1               5                   10                  15      


Gln Gly Gly Gly Ala Ala Ala Pro Gly Ala Asn Gln Gly Gly Gly Ala 
            20                  25                  30          


Ala Ala Pro Gly Ala Asn Gln Glu Gly Gly Ala Ala Ala Pro Gly Ala 
        35                  40                  45              


Asn Gln Glu Gly Gly Ala Ala Ala Pro Gly Ala Asn Gln Glu Gly Gly 
    50                  55                  60                  


Ala Ala 
65      


<210>  28
<211>  246
<212>  DNA
<213>  Plasmodium vivax

<400>  28
caagctgctg gtggtaatgc tggtggtggt cagggtcaaa acaacgaggg tgctaatgct       60

ccaaacgaga agtccgttaa ggaatacttg gacaaagtta gagctactgt tggtactgag      120

tggactccat gttccgttac ttgtggtgtt ggtgttagag ttagaagaag agttaacgct      180

gctaacaaga agccagagga cttgactttg aacgacttgg agactgacgt ttgtactatg      240

gacaag                                                                 246


<210>  29
<211>  82
<212>  PRT
<213>  Plasmodium vivax

<400>  29

Gln Ala Ala Gly Gly Asn Ala Gly Gly Gly Gln Gly Gln Asn Asn Glu 
1               5                   10                  15      


Gly Ala Asn Ala Pro Asn Glu Lys Ser Val Lys Glu Tyr Leu Asp Lys 
            20                  25                  30          


Val Arg Ala Thr Val Gly Thr Glu Trp Thr Pro Cys Ser Val Thr Cys 
        35                  40                  45              


Gly Val Gly Val Arg Val Arg Arg Arg Val Asn Ala Ala Asn Lys Lys 
    50                  55                  60                  


Pro Glu Asp Leu Thr Leu Asn Asp Leu Glu Thr Asp Val Cys Thr Met 
65                  70                  75                  80  


Asp Lys 
        


<210>  30
<211>  43
<212>  PRT
<213>  Plasmodium vivax

<400>  30

Glu Trp Thr Pro Cys Ser Val Thr Cys Gly Val Gly Val Arg Val Arg 
1               5                   10                  15      


Arg Arg Val Asn Ala Ala Asn Lys Lys Pro Glu Asp Leu Thr Leu Asn 
            20                  25                  30          


Asp Leu Glu Thr Asp Val Cys Thr Met Asp Lys 
        35                  40              


<210>  31
<211>  10
<212>  PRT
<213>  Plasmodium vivax

<400>  31

Glu Trp Thr Pro Cys Ser Val Thr Cys Gly 
1               5                   10  


<210>  32
<211>  6
<212>  PRT
<213>  Plasmodium vivax

<400>  32

Cys Ser Val Thr Cys Gly 
1               5       


<210>  33
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Insertion

<400>  33

Gly Ala Gly Gly Gln Ala Ala Gly Gly Asn Ala 
1               5                   10      


<210>  34
<211>  228
<212>  DNA
<213>  Plasmodium vivax

<400>  34
acccactgcg gccacaacgt ggacctgagc aaggccatca acctgaacgg cgtgaacttc       60

aacaatgtgg acgcctctag cctgggagct gctcacgtgg gccagagcgc cagcagaggc      120

agaggcctgg gcgagaaccc cgacgatgag gaaggcgacg ccaagaagaa gaaggacggc      180

aagaaggccg agcccaagaa ccccagagag aacaagctga agcagccc                   228


<210>  35
<211>  76
<212>  PRT
<213>  Plasmodium vivax

<400>  35

Thr His Cys Gly His Asn Val Asp Leu Ser Lys Ala Ile Asn Leu Asn 
1               5                   10                  15      


Gly Val Asn Phe Asn Asn Val Asp Ala Ser Ser Leu Gly Ala Ala His 
            20                  25                  30          


Val Gly Gln Ser Ala Ser Arg Gly Arg Gly Leu Gly Glu Asn Pro Asp 
        35                  40                  45              


Asp Glu Glu Gly Asp Ala Lys Lys Lys Lys Asp Gly Lys Lys Ala Glu 
    50                  55                  60                  


Pro Lys Asn Pro Arg Glu Asn Lys Leu Lys Gln Pro 
65                  70                  75      


<210>  36
<211>  5
<212>  PRT
<213>  Plasmodium vivax

<400>  36

Lys Leu Lys Gln Pro 
1               5   


<210>  37
<211>  690
<212>  DNA
<213>  Hepatitis B virus

<400>  37
ccagttacta atatggaaaa catcacttcc ggtttcttgg gtcctttgtt ggttttgcag       60

gctggattct tcttgttgac tagaatcttg actatcccac agtccttgga ctcttggtgg      120

acttccttga acttcttggg tggttcccca gtttgtttgg gtcagaactc tcaatcccca      180

acttctaacc actccccaac atcctgtcct ccaatttgtc caggttacag atggatgtgt      240

ttgagaagat tcatcatttt cttgttcatc ttgttgttgt gtttgatctt cttgttggtt      300

ttgttggact accagggtat gttgccagtt tgtccattga tcccaggttc cactactaca      360

aacactggtc catgtaagac ttgtactact ccagctcagg gtaactctat gttcccttcc      420

tgttgttgta ctaagccaac tgacggtaac tgtacttgta tcccaattcc atcctcctgg      480

gctttcgcta agtacttgtg ggaatgggct tccgttagat tctcttggtt gtccttgttg      540

gttccattcg ttcagtggtt cgttggtttg tccccaactg tttggttgtc tgctatctgg      600

atgatgtggt actggggtcc atccttgtac tctatcgttt ccccattcat ccctttgttg      660

ccaatcttct tctgtttgtg ggtttacatc                                       690


<210>  38
<211>  230
<212>  PRT
<213>  Hepatitis B virus

<400>  38

Pro Val Thr Asn Met Glu Asn Ile Thr Ser Gly Phe Leu Gly Pro Leu 
1               5                   10                  15      


Leu Val Leu Gln Ala Gly Phe Phe Leu Leu Thr Arg Ile Leu Thr Ile 
            20                  25                  30          


Pro Gln Ser Leu Asp Ser Trp Trp Thr Ser Leu Asn Phe Leu Gly Gly 
        35                  40                  45              


Ser Pro Val Cys Leu Gly Gln Asn Ser Gln Ser Pro Thr Ser Asn His 
    50                  55                  60                  


Ser Pro Thr Ser Cys Pro Pro Ile Cys Pro Gly Tyr Arg Trp Met Cys 
65                  70                  75                  80  


Leu Arg Arg Phe Ile Ile Phe Leu Phe Ile Leu Leu Leu Cys Leu Ile 
                85                  90                  95      


Phe Leu Leu Val Leu Leu Asp Tyr Gln Gly Met Leu Pro Val Cys Pro 
            100                 105                 110         


Leu Ile Pro Gly Ser Thr Thr Thr Asn Thr Gly Pro Cys Lys Thr Cys 
        115                 120                 125             


Thr Thr Pro Ala Gln Gly Asn Ser Met Phe Pro Ser Cys Cys Cys Thr 
    130                 135                 140                 


Lys Pro Thr Asp Gly Asn Cys Thr Cys Ile Pro Ile Pro Ser Ser Trp 
145                 150                 155                 160 


Ala Phe Ala Lys Tyr Leu Trp Glu Trp Ala Ser Val Arg Phe Ser Trp 
                165                 170                 175     


Leu Ser Leu Leu Val Pro Phe Val Gln Trp Phe Val Gly Leu Ser Pro 
            180                 185                 190         


Thr Val Trp Leu Ser Ala Ile Trp Met Met Trp Tyr Trp Gly Pro Ser 
        195                 200                 205             


Leu Tyr Ser Ile Val Ser Pro Phe Ile Pro Leu Leu Pro Ile Phe Phe 
    210                 215                 220                 


Cys Leu Trp Val Tyr Ile 
225                 230 


<210>  39
<211>  492
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hepatitus B virus + Plasmodium vivax virus-like particle

<400>  39

Gly Asp Arg Ala Ala Gly Gln Pro Ala Gly Asp Arg Ala Ala Gly Gln 
1               5                   10                  15      


Pro Ala Gly Asp Arg Ala Ala Gly Gln Pro Ala Gly Asp Arg Ala Ala 
            20                  25                  30          


Gly Gln Pro Ala Gly Asp Arg Ala Ala Gly Gln Pro Ala Gly Asp Arg 
        35                  40                  45              


Ala Asp Gly Gln Pro Ala Gly Asp Arg Ala Asp Gly Gln Pro Ala Gly 
    50                  55                  60                  


Asp Arg Ala Asp Gly Gln Pro Ala Gly Asp Arg Ala Asp Gly Gln Pro 
65                  70                  75                  80  


Ala Gly Asn Gly Ala Gly Gly Gln Ala Ala Ala Asn Gly Ala Gly Asn 
                85                  90                  95      


Gln Pro Gly Ala Asn Gly Ala Gly Gly Gln Ala Ala Ala Asn Gly Ala 
            100                 105                 110         


Gly Asn Gln Pro Gly Ala Asn Gly Ala Gly Gly Gln Ala Ala Ala Asn 
        115                 120                 125             


Gly Ala Gly Asp Gln Pro Gly Ala Asn Gly Ala Gly Asp Gln Pro Gly 
    130                 135                 140                 


Ala Asn Gly Ala Asp Asp Gln Pro Gly Ala Asn Gly Ala Gly Asp Gln 
145                 150                 155                 160 


Pro Gly Glu Asp Gly Ala Gly Asn Gln Pro Gly Ala Asn Gly Ala Gly 
                165                 170                 175     


Asp Gln Pro Gly Gln Ala Ala Gly Gly Asn Ala Gly Gly Gly Gln Gly 
            180                 185                 190         


Gln Asn Asn Glu Gly Ala Asn Ala Pro Asn Glu Lys Ser Val Lys Glu 
        195                 200                 205             


Tyr Leu Asp Lys Val Arg Ala Thr Val Gly Thr Glu Trp Thr Pro Cys 
    210                 215                 220                 


Ser Val Thr Cys Gly Val Gly Val Arg Val Arg Arg Arg Val Asn Ala 
225                 230                 235                 240 


Ala Asn Lys Lys Pro Glu Asp Leu Thr Leu Asn Asp Leu Glu Thr Asp 
                245                 250                 255     


Val Cys Thr Met Asp Lys Pro Val Thr Asn Met Glu Asn Ile Thr Ser 
            260                 265                 270         


Gly Phe Leu Gly Pro Leu Leu Val Leu Gln Ala Gly Phe Phe Leu Leu 
        275                 280                 285             


Thr Arg Ile Leu Thr Ile Pro Gln Ser Leu Asp Ser Trp Trp Thr Ser 
    290                 295                 300                 


Leu Asn Phe Leu Gly Gly Ser Pro Val Cys Leu Gly Gln Asn Ser Gln 
305                 310                 315                 320 


Ser Pro Thr Ser Asn His Ser Pro Thr Ser Cys Pro Pro Ile Cys Pro 
                325                 330                 335     


Gly Tyr Arg Trp Met Cys Leu Arg Arg Phe Ile Ile Phe Leu Phe Ile 
            340                 345                 350         


Leu Leu Leu Cys Leu Ile Phe Leu Leu Val Leu Leu Asp Tyr Gln Gly 
        355                 360                 365             


Met Leu Pro Val Cys Pro Leu Ile Pro Gly Ser Thr Thr Thr Asn Thr 
    370                 375                 380                 


Gly Pro Cys Lys Thr Cys Thr Thr Pro Ala Gln Gly Asn Ser Met Phe 
385                 390                 395                 400 


Pro Ser Cys Cys Cys Thr Lys Pro Thr Asp Gly Asn Cys Thr Cys Ile 
                405                 410                 415     


Pro Ile Pro Ser Ser Trp Ala Phe Ala Lys Tyr Leu Trp Glu Trp Ala 
            420                 425                 430         


Ser Val Arg Phe Ser Trp Leu Ser Leu Leu Val Pro Phe Val Gln Trp 
        435                 440                 445             


Phe Val Gly Leu Ser Pro Thr Val Trp Leu Ser Ala Ile Trp Met Met 
    450                 455                 460                 


Trp Tyr Trp Gly Pro Ser Leu Tyr Ser Ile Val Ser Pro Phe Ile Pro 
465                 470                 475                 480 


Leu Leu Pro Ile Phe Phe Cys Leu Trp Val Tyr Ile 
                485                 490         


<210>  40
<211>  556
<212>  PRT
<213>  Plasmodium vivax

<400>  40

Met Lys Leu Leu Gln Asn Lys Ser Tyr Leu Leu Val Val Phe Leu Leu 
1               5                   10                  15      


Tyr Val Ser Ile Phe Ala Arg Gly Asp Glu Lys Val Val Asp Glu Val 
            20                  25                  30          


Lys Tyr Ser Glu Glu Val Cys Asn Glu Ser Val Asp Leu Tyr Leu Leu 
        35                  40                  45              


Val Asp Gly Ser Gly Ser Ile Gly Tyr Pro Asn Trp Ile Thr Lys Val 
    50                  55                  60                  


Ile Pro Met Leu Asn Gly Leu Ile Asn Ser Leu Ser Leu Ser Arg Asp 
65                  70                  75                  80  


Thr Ile Asn Leu Tyr Met Asn Leu Phe Gly Asn Tyr Thr Thr Glu Leu 
                85                  90                  95      


Ile Arg Leu Gly Ser Gly Gln Ser Ile Asp Lys Arg Gln Ala Leu Ser 
            100                 105                 110         


Lys Val Thr Glu Leu Arg Lys Thr Tyr Thr Pro Tyr Gly Thr Thr Asn 
        115                 120                 125             


Met Thr Ala Ala Leu Asp Glu Val Gln Lys His Leu Asn Asp Arg Val 
    130                 135                 140                 


Asn Arg Glu Lys Ala Ile Gln Leu Val Ile Leu Met Thr Asp Gly Val 
145                 150                 155                 160 


Pro Asn Ser Lys Tyr Arg Ala Leu Glu Val Ala Asn Lys Leu Lys Gln 
                165                 170                 175     


Arg Asn Val Ser Leu Ala Val Ile Gly Ile Gly Gln Gly Ile Asn His 
            180                 185                 190         


Gln Phe Asn Arg Leu Ile Ala Gly Cys Arg Pro Arg Glu Pro Asn Cys 
        195                 200                 205             


Lys Phe Tyr Ser Tyr Ala Asp Trp Asn Glu Ala Val Ala Leu Ile Lys 
    210                 215                 220                 


Pro Phe Ile Ala Lys Val Cys Thr Glu Val Glu Arg Val Ala Asn Cys 
225                 230                 235                 240 


Gly Pro Trp Asp Pro Trp Thr Ala Cys Ser Val Thr Cys Gly Arg Gly 
                245                 250                 255     


Thr His Ser Arg Ser Arg Pro Ser Leu His Glu Lys Cys Thr Thr His 
            260                 265                 270         


Met Val Ser Glu Cys Glu Glu Gly Glu Cys Pro Val Glu Pro Glu Pro 
        275                 280                 285             


Leu Pro Val Pro Ala Pro Leu Pro Thr Val Pro Glu Asp Val Asn Pro 
    290                 295                 300                 


Arg Asp Thr Asp Asp Glu Asn Glu Asn Pro Asn Phe Asn Lys Gly Leu 
305                 310                 315                 320 


Asp Val Pro Asp Glu Asp Asp Asp Glu Val Pro Pro Ala Asn Glu Arg 
                325                 330                 335     


Ala Asp Gly Asn Pro Val Glu Glu Asn Val Phe Pro Pro Ala Asp Asp 
            340                 345                 350         


Ser Val Pro Asp Glu Ser Asn Val Leu Pro Leu Pro Pro Ala Val Pro 
        355                 360                 365             


Gly Gly Ser Ser Glu Glu Phe Pro Ala Asp Val Gln Asn Asn Pro Asp 
    370                 375                 380                 


Ser Pro Glu Glu Leu Pro Met Glu Gln Glu Val Pro Gln Asp Asn Asn 
385                 390                 395                 400 


Val Asn Glu Pro Glu Arg Ser Asp Ser Lys Gly Tyr Gly Val Asn Glu 
                405                 410                 415     


Lys Val Ile Pro Asn Pro Leu Asp Asn Glu Arg Asp Met Ala Asn Lys 
            420                 425                 430         


Asn Lys Thr Val His Pro Gly Arg Lys Asp Ser Ala Arg Asp Arg Tyr 
        435                 440                 445             


Ala Arg Pro His Gly Ser Thr His Val Asn Asn Asn Arg Ala Asn Glu 
    450                 455                 460                 


Asn Ser Asp Ile Pro Asn Asn Pro Val Pro Ser Asp Tyr Glu Gln Pro 
465                 470                 475                 480 


Glu Asp Lys Ala Lys Lys Ser Ser Asn Asn Gly Tyr Lys Ile Ala Gly 
                485                 490                 495     


Gly Val Ile Ala Gly Leu Ala Leu Val Gly Cys Val Gly Phe Ala Tyr 
            500                 505                 510         


Asn Phe Val Ala Gly Gly Gly Ala Ala Gly Met Ala Gly Glu Pro Ala 
        515                 520                 525             


Pro Phe Asp Glu Ala Met Ala Glu Asp Glu Lys Asp Val Ala Glu Ala 
    530                 535                 540                 


Asp Gln Phe Lys Leu Pro Glu Asp Asn Glu Trp Asn 
545                 550                 555     


<210>  41
<211>  469
<212>  PRT
<213>  Plasmodium vivax

<400>  41

Asp Glu Lys Val Val Asp Glu Val Lys Tyr Ser Glu Glu Val Cys Asn 
1               5                   10                  15      


Glu Ser Val Asp Leu Tyr Leu Leu Val Asp Gly Ser Gly Ser Ile Gly 
            20                  25                  30          


Tyr Pro Asn Trp Ile Thr Lys Val Ile Pro Met Leu Asn Gly Leu Ile 
        35                  40                  45              


Asn Ser Leu Ser Leu Ser Arg Asp Thr Ile Asn Leu Tyr Met Asn Leu 
    50                  55                  60                  


Phe Gly Asn Tyr Thr Thr Glu Leu Ile Arg Leu Gly Ser Gly Gln Ser 
65                  70                  75                  80  


Ile Asp Lys Arg Gln Ala Leu Ser Lys Val Thr Glu Leu Arg Lys Thr 
                85                  90                  95      


Tyr Thr Pro Tyr Gly Thr Thr Asn Met Thr Ala Ala Leu Asp Glu Val 
            100                 105                 110         


Gln Lys His Leu Asn Asp Arg Val Asn Arg Glu Lys Ala Ile Gln Leu 
        115                 120                 125             


Val Ile Leu Met Thr Asp Gly Val Pro Asn Ser Lys Tyr Arg Ala Leu 
    130                 135                 140                 


Glu Val Ala Asn Lys Leu Lys Gln Arg Asn Val Ser Leu Ala Val Ile 
145                 150                 155                 160 


Gly Val Gly Gln Gly Ile Asn His Gln Phe Asn Arg Leu Ile Ala Gly 
                165                 170                 175     


Cys Arg Pro Arg Glu Pro Asn Cys Lys Phe Tyr Ser Tyr Ala Asp Trp 
            180                 185                 190         


Asn Glu Ala Val Ala Leu Ile Lys Pro Phe Ile Ala Lys Val Cys Thr 
        195                 200                 205             


Glu Val Glu Arg Val Ala Asn Cys Gly Pro Trp Asp Pro Trp Thr Ala 
    210                 215                 220                 


Cys Ser Val Thr Cys Gly Arg Gly Thr His Ser Arg Ser Arg Pro Ser 
225                 230                 235                 240 


Leu His Glu Lys Cys Thr Thr His Met Val Ser Glu Cys Glu Glu Gly 
                245                 250                 255     


Glu Cys Pro Val Glu Pro Glu Pro Leu Pro Val Pro Ala Pro Leu Pro 
            260                 265                 270         


Thr Val Pro Glu Asp Val Asn Pro Arg Asp Thr Asp Asp Glu Asn Glu 
        275                 280                 285             


Asn Pro Asn Phe Asn Lys Gly Leu Asp Val Pro Asp Glu Asp Asp Asp 
    290                 295                 300                 


Glu Val Pro Pro Ala Asn Glu Gly Ala Asp Gly Asn Pro Val Glu Glu 
305                 310                 315                 320 


Asn Val Phe Pro Pro Ala Asp Asp Ser Val Pro Asp Glu Ser Asn Val 
                325                 330                 335     


Leu Pro Leu Pro Pro Ala Val Pro Gly Gly Ser Ser Glu Glu Phe Pro 
            340                 345                 350         


Ala Asp Val Gln Asn Asn Pro Asp Ser Pro Glu Glu Leu Pro Met Glu 
        355                 360                 365             


Gln Glu Val Pro Gln Asp Asn Asn Val Asn Glu Pro Glu Arg Ser Asp 
    370                 375                 380                 


Ser Asn Gly Tyr Gly Val Asn Glu Lys Val Ile Pro Asn Pro Leu Asp 
385                 390                 395                 400 


Asn Glu Arg Asp Met Ala Asn Lys Asn Lys Thr Val His Pro Gly Arg 
                405                 410                 415     


Lys Asp Ser Ala Arg Asp Arg Tyr Ala Arg Pro His Gly Ser Thr His 
            420                 425                 430         


Val Asn Asn Asn Arg Ala Asn Glu Asn Ser Asp Ile Pro Asn Asn Pro 
        435                 440                 445             


Val Pro Ser Asp Tyr Glu Gln Pro Glu Asp Lys Ala Lys Lys Ser Ser 
    450                 455                 460                 


Asn Asn Gly Tyr Lys 
465                 


<210>  42
<211>  12
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C-tag

<400>  42
gagcccgagg cc                                                           12


<210>  43
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C-tag

<400>  43

Glu Pro Glu Ala 
1               


<210>  44
<211>  597
<212>  DNA
<213>  Plasmodium vivax

<400>  44
atggccgtca cggtagacac catatgcaaa aatggacagc tggttcaaat gagtaaccac       60

tttaagtgta tgtgtaacga agggctggtg cacctttccg aaaatacatg tgaagaaaaa      120

aatgaatgca agaaagaaac cctaggcaaa gcatgcgggg aatttggcca gtgtatagaa      180

aacccagacc cagcacaggt aaacatgtac aaatgtggtt gcattgaggg ctacactttg      240

aaggaagaca cttgtgtgct tgatgtatgt caatacaaaa attgtggaga aagtggcgaa      300

tgcattgttg agtacctctc ggaaatccaa agtgcaggtt gctcatgtgc tattggcaaa      360

gtccccaatc cagaagatga gaaaaaatgt accaaaacgg gagaaactgc ttgtcaattg      420

aaatgtaaca cagataatga agtctgcaaa aatgttgaag gagtttacaa gtgccagtgt      480

atggaaggct ttacgttcga caaagagaaa aatgtatgcc tttcctattc tgtatttaac      540

atcctaaact actccctctt ctttatcatc ctgcttgtcc tttcgtacgt catataa         597


<210>  45
<211>  198
<212>  PRT
<213>  Plasmodium vivax

<400>  45

Met Ala Val Thr Val Asp Thr Ile Cys Lys Asn Gly Gln Leu Val Gln 
1               5                   10                  15      


Met Ser Asn His Phe Lys Cys Met Cys Asn Glu Gly Leu Val His Leu 
            20                  25                  30          


Ser Glu Asn Thr Cys Glu Glu Lys Asn Glu Cys Lys Lys Glu Thr Leu 
        35                  40                  45              


Gly Lys Ala Cys Gly Glu Phe Gly Gln Cys Ile Glu Asn Pro Asp Pro 
    50                  55                  60                  


Ala Gln Val Asn Met Tyr Lys Cys Gly Cys Ile Glu Gly Tyr Thr Leu 
65                  70                  75                  80  


Lys Glu Asp Thr Cys Val Leu Asp Val Cys Gln Tyr Lys Asn Cys Gly 
                85                  90                  95      


Glu Ser Gly Glu Cys Ile Val Glu Tyr Leu Ser Glu Ile Gln Ser Ala 
            100                 105                 110         


Gly Cys Ser Cys Ala Ile Gly Lys Val Pro Asn Pro Glu Asp Glu Lys 
        115                 120                 125             


Lys Cys Thr Lys Thr Gly Glu Thr Ala Cys Gln Leu Lys Cys Asn Thr 
    130                 135                 140                 


Asp Asn Glu Val Cys Lys Asn Val Glu Gly Val Tyr Lys Cys Gln Cys 
145                 150                 155                 160 


Met Glu Gly Phe Thr Phe Asp Lys Glu Lys Asn Val Cys Leu Ser Tyr 
                165                 170                 175     


Ser Val Phe Asn Ile Leu Asn Tyr Ser Leu Phe Phe Ile Ile Leu Leu 
            180                 185                 190         


Val Leu Ser Tyr Val Ile 
        195             


<210>  46
<211>  215
<212>  PRT
<213>  Plasmodium vivax

<400>  46

Met Lys Val Thr Ala Glu Thr Gln Cys Lys Asn Gly Tyr Val Val Gln 
1               5                   10                  15      


Met Ser Asn His Phe Glu Cys Lys Cys Asn Asp Gly Phe Val Met Ala 
            20                  25                  30          


Asn Glu Asn Thr Cys Glu Glu Lys Arg Asp Cys Thr Asn Pro Gln Asn 
        35                  40                  45              


Val Asn Lys Asn Cys Gly Asp Tyr Ala Val Cys Ala Asn Thr Arg Met 
    50                  55                  60                  


Asn Asp Glu Glu Arg Ala Leu Arg Cys Gly Cys Ile Leu Gly Tyr Thr 
65                  70                  75                  80  


Val Met Asn Glu Val Cys Thr Pro Asn Lys Cys Asn Gly Val Leu Cys 
                85                  90                  95      


Gly Lys Gly Lys Cys Ile Leu Asp Pro Ala Asn Val Asn Ser Thr Met 
            100                 105                 110         


Cys Ser Cys Asn Ile Gly Thr Thr Leu Asp Glu Ser Lys Lys Cys Gly 
        115                 120                 125             


Lys Pro Gly Lys Thr Glu Cys Thr Leu Lys Cys Lys Ala Asn Glu Glu 
    130                 135                 140                 


Cys Lys Glu Thr Gln Asn Tyr Tyr Lys Cys Val Ala Lys Gly Ser Gly 
145                 150                 155                 160 


Gly Glu Gly Ser Gly Gly Glu Gly Ser Gly Gly Glu Gly Ser Gly Gly 
                165                 170                 175     


Glu Gly Ser Gly Gly Glu Gly Ser Gly Gly Asp Thr Gly Ala Ala Tyr 
            180                 185                 190         


Ser Leu Met Asn Gly Ser Ala Val Ile Ser Ile Leu Leu Val Phe Ala 
        195                 200                 205             


Phe Phe Met Met Ser Leu Val 
    210                 215 


<210>  47
<211>  412
<212>  PRT
<213>  Plasmodium vivax

<400>  47

Met Ala Val Thr Val Asp Thr Ile Cys Lys Asn Gly Gln Leu Val Gln 
1               5                   10                  15      


Met Ser Asn His Phe Lys Cys Met Cys Asn Glu Gly Leu Val His Leu 
            20                  25                  30          


Ser Glu Asn Thr Cys Glu Glu Lys Asn Glu Cys Lys Lys Glu Thr Leu 
        35                  40                  45              


Gly Lys Ala Cys Gly Glu Phe Gly Gln Cys Ile Glu Asn Pro Asp Pro 
    50                  55                  60                  


Ala Gln Val Asn Met Tyr Lys Cys Gly Cys Ile Glu Gly Tyr Thr Leu 
65                  70                  75                  80  


Lys Glu Asp Thr Cys Val Leu Asp Val Cys Gln Tyr Lys Asn Cys Gly 
                85                  90                  95      


Glu Ser Gly Glu Cys Ile Val Glu Tyr Leu Ser Glu Ile Gln Ser Ala 
            100                 105                 110         


Gly Cys Ser Cys Ala Ile Gly Lys Val Pro Asn Pro Glu Asp Glu Lys 
        115                 120                 125             


Lys Cys Thr Lys Thr Gly Glu Thr Ala Cys Gln Leu Lys Cys Asn Thr 
    130                 135                 140                 


Asp Asn Glu Val Cys Lys Asn Val Glu Gly Val Tyr Lys Cys Gln Cys 
145                 150                 155                 160 


Met Glu Gly Phe Thr Phe Asp Lys Glu Lys Asn Val Cys Leu Ser Tyr 
                165                 170                 175     


Ser Val Phe Asn Ile Leu Asn Tyr Ser Leu Phe Phe Ile Ile Leu Leu 
            180                 185                 190         


Val Leu Ser Tyr Val Ile Lys Val Thr Ala Glu Thr Gln Cys Lys Asn 
        195                 200                 205             


Gly Tyr Val Val Gln Met Ser Asn His Phe Glu Cys Lys Cys Asn Asp 
    210                 215                 220                 


Gly Phe Val Met Ala Asn Glu Asn Thr Cys Glu Glu Lys Arg Asp Cys 
225                 230                 235                 240 


Thr Asn Pro Gln Asn Val Asn Lys Asn Cys Gly Asp Tyr Ala Val Cys 
                245                 250                 255     


Ala Asn Thr Arg Met Asn Asp Glu Glu Arg Ala Leu Arg Cys Gly Cys 
            260                 265                 270         


Ile Leu Gly Tyr Thr Val Met Asn Glu Val Cys Thr Pro Asn Lys Cys 
        275                 280                 285             


Asn Gly Val Leu Cys Gly Lys Gly Lys Cys Ile Leu Asp Pro Ala Asn 
    290                 295                 300                 


Val Asn Ser Thr Met Cys Ser Cys Asn Ile Gly Thr Thr Leu Asp Glu 
305                 310                 315                 320 


Ser Lys Lys Cys Gly Lys Pro Gly Lys Thr Glu Cys Thr Leu Lys Cys 
                325                 330                 335     


Lys Ala Asn Glu Glu Cys Lys Glu Thr Gln Asn Tyr Tyr Lys Cys Val 
            340                 345                 350         


Ala Lys Gly Ser Gly Gly Glu Gly Ser Gly Gly Glu Gly Ser Gly Gly 
        355                 360                 365             


Glu Gly Ser Gly Gly Glu Gly Ser Gly Gly Glu Gly Ser Gly Gly Asp 
    370                 375                 380                 


Thr Gly Ala Ala Tyr Ser Leu Met Asn Gly Ser Ala Val Ile Ser Ile 
385                 390                 395                 400 


Leu Leu Val Phe Ala Phe Phe Met Met Ser Leu Val 
                405                 410         


<210>  48
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PvCSP-trans (F6) primer

<400>  48
tgacatgcat atgtgttggt tg                                                22


<210>  49
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PvCSP-trans (R5) primer

<400>  49
gctgattgtc caacatgtgc                                                   20


<210>  50
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  1054 primer

<400>  50
ccaaaggaac ttaaacgagc tatg                                              24


<210>  51
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  1055 primer

<400>  51
cttataccag aaccacatgt tacg                                              24


<210>  52
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  7393 primer

<400>  52
atcgactagt aaagcctcgc tacg                                              24


<210>  53
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  7394 primer

<400>  53
gtgagtcaga tggactttct ggtag                                             25


