                         SEQUENCE LISTING

<110>  Klinikum rechts der Isar der Technischen Universitt 
       Mnchen
 
<120>  VSV/NDV hybrid viruses for oncolytic therapy of cancer

<130>  U30713WO

<150>  EP 16 170 445.7

<151>  2016-05-19

<160>  17    

<170>  PatentIn version 3.5

<210>  1
<211>  11161
<212>  DNA
<213>  Vesicular stomatitis virus

<400>  1
acgaagacaa acaaaccatt attatcatta aaaggctcag gagaaacttt aacagtaatc       60

aaaatgtctg ttacagtcaa gagaatcatt gacaacacag tcatagttcc aaaacttcct      120

gcaaatgagg atccagtgga atacccggca gattacttca gaaaatcaaa ggagattcct      180

ctttacatca atactacaaa aagtttgtca gatctaagag gatatgtcta ccaaggcctc      240

aaatccggaa atgtatcaat catacatgtc aacagctact tgtatggagc attaaaggac      300

atccggggta agttggataa agattggtca agtttcggaa taaacatcgg gaaagcaggg      360

gatacaatcg gaatatttga ccttgtatcc ttgaaagccc tggacggcgt acttccagat      420

ggagtatcgg atgcttccag aaccagcgca gatgacaaat ggttgccttt gtatctactt      480

ggcttataca gagtgggcag aacacaaatg cctgaataca gaaaaaagct catggatggg      540

ctgacaaatc aatgcaaaat gatcaatgaa cagtttgaac ctcttgtgcc agaaggtcgt      600

gacatttttg atgtgtgggg aaatgacagt aattacacaa aaattgtcgc tgcagtggac      660

atgttcttcc acatgttcaa aaaacatgaa tgtgcctcgt tcagatacgg aactattgtt      720

tccagattca aagattgtgc tgcattggca acatttggac acctctgcaa aataaccgga      780

atgtctacag aagatgtaac gacctggatc ttgaaccgag aagttgcaga tgaaatggtc      840

caaatgatgc ttccaggcca agaaattgac aaggccgatt catacatgcc ttatttgatc      900

gactttggat tgtcttctaa gtctccatat tcttccgtca aaaaccctgc cttccacttc      960

tgggggcaat tgacagctct tctgctcaga tccaccagag caaggaatgc ccgacagcct     1020

gatgacattg agtatacatc tcttactaca gcaggtttgt tgtacgctta tgcagtagga     1080

tcctctgccg acttggcaca acagttttgt gttggagata acaaatacac tccagatgat     1140

agtaccggag gattgacgac taatgcaccg ccacaaggca gagatgtggt cgaatggctc     1200

ggatggtttg aagatcaaaa cagaaaaccg actcctgata tgatgcagta tgcgaaaaga     1260

gcagtcatgt cactgcaagg cctaagagag aagacaattg gcaagtatgc taagtcagaa     1320

tttgacaaat gaccctataa ttctcagatc acctattata tattatgcta catatgaaaa     1380

aaactaacag atatcatgga taatctcaca aaagttcgtg agtatctcaa gtcctattct     1440

cgtctggatc aggcggtagg agagatagat gagatcgaag cacaacgagc tgaaaagtcc     1500

aattatgagt tgttccaaga ggatggagtg gaagagcata ctaagccctc ttattttcag     1560

gcagcagatg attctgacac agaatctgaa ccagaaattg aagacaatca aggtttgtat     1620

gcacaggatc cagaagctga gcaagttgaa ggctttatac aggggccttt agatgactat     1680

gcagatgagg aagtggatgt tgtatttact tcggactgga aaccacctga gcttgaatct     1740

gacgagcatg gaaagacctt acggttgaca tcgccagagg gtttaagtgg agagcagaaa     1800

tcccagtggc tttcgacgat taaagcagtc gtgcaaagtg ccaaatactg gaatctggca     1860

gagtgcacat ttgaagcatc gggagaaggg gtcattatga aggagcgcca gataactccg     1920

gatgtatata aggtcactcc agtgatgaac acacatccgt cccaatcaga agcagtatca     1980

gatgtttggt ctctctcaaa gacatccatg actttccaac ccaagaaagc aagtcttcag     2040

cctctcacca tatccttgga tgaattgttc tcatctagag gagagttcat ctctgtcgga     2100

ggtgacggac gaatgtctca taaagaggcc atcctgctcg gcctgagata caaaaagttg     2160

tacaatcagg cgagagtcaa atattctctg tagactatga aaaaaagtaa cagatatcac     2220

gatctaagtg ttatcccaat ccattcatca tgagttcctt aaagaagatt ctcggtctga     2280

aggggaaagg taagaaatct aagaaattag ggatcgcacc acccccttat gaagaggaca     2340

ctagcatgga gtatgctccg agcgctccaa ttgacaaatc ctattttgga gttgacgaga     2400

tggacaccta tgatccgaat caattaagat atgagaaatt cttctttaca gtgaaaatga     2460

cggttagatc taatcgtccg ttcagaacat actcagatgt ggcagccgct gtatcccatt     2520

gggatcacat gtacatcgga atggcaggga aacgtccctt ctacaaaatc ttggcttttt     2580

tgggttcttc taatctaaag gccactccag cggtattggc agatcaaggt caaccagagt     2640

atcacactca ctgcgaaggc agggcttatt tgccacatag gatggggaag acccctccca     2700

tgctcaatgt accagagcac ttcagaagac cattcaatat aggtctttac aagggaacga     2760

ttgagctcac aatgaccatc tacgatgatg agtcactgga agcagctcct atgatctggg     2820

atcatttcaa ttcttccaaa ttttctgatt tcagagagaa ggccttaatg tttggcctga     2880

ttgtcgagaa aaaggcatct ggagcgtggg tcctggattc tatcagccac ttcaaatgag     2940

ctagtctaac ttctagcttc tgaacaatcc ccggtttact cagtctctcc taattccagc     3000

ctctcgaaca actaatatcc tgtcttttct atccctatga aaaaaactaa cagagatcga     3060

tctgtttcct tgacactatg aagtgccttt tgtacttagc ctttttattc attggggtga     3120

attgcaagtt caccatagtt tttccacaca accaaaaagg aaactggaaa aatgttcctt     3180

ctaattacca ttattgcccg tcaagctcag atttaaattg gcataatgac ttaataggca     3240

cagccataca agtcaaaatg cccaagagtc acaaggctat tcaagcagac ggttggatgt     3300

gtcatgcttc caaatgggtc actacttgtg atttccgctg gtatggaccg aagtatataa     3360

cacagtccat ccgatccttc actccatctg tagaacaatg caaggaaagc attgaacaaa     3420

cgaaacaagg aacttggctg aatccaggct tccctcctca aagttgtgga tatgcaactg     3480

tgacggatgc cgaagcagtg attgtccagg tgactcctca ccatgtgctg gttgatgaat     3540

acacaggaga atgggttgat tcacagttca tcaacggaaa atgcagcaat tacatatgcc     3600

ccactgtcca taactctaca acctggcatt ctgactataa ggtcaaaggg ctatgtgatt     3660

ctaacctcat ttccatggac atcaccttct tctcagagga cggagagcta tcatccctgg     3720

gaaaggaggg cacagggttc agaagtaact actttgctta tgaaactgga ggcaaggcct     3780

gcaaaatgca atactgcaag cattggggag tcagactccc atcaggtgtc tggttcgaga     3840

tggctgataa ggatctcttt gctgcagcca gattccctga atgcccagaa gggtcaagta     3900

tctctgctcc atctcagacc tcagtggatg taagtctaat tcaggacgtt gagaggatct     3960

tggattattc cctctgccaa gaaacctgga gcaaaatcag agcgggtctt ccaatctctc     4020

cagtggatct cagctatctt gctcctaaaa acccaggaac cggtcctgct ttcaccataa     4080

tcaatggtac cctaaaatac tttgagacca gatacatcag agtcgatatt gctgctccaa     4140

tcctctcaag aatggtcgga atgatcagtg gaactaccac agaaagggaa ctgtgggatg     4200

actgggcacc atatgaagac gtggaaattg gacccaatgg agttctgagg accagttcag     4260

gatataagtt tcctttatac atgattggac atggtatgtt ggactccgat cttcatctta     4320

gctcaaaggc tcaggtgttc gaacatcctc acattcaaga cgctgcttcg caacttcctg     4380

atgatgagag tttatttttt ggtgatactg ggctatccaa aaatccaatc gagcttgtag     4440

aaggttggtt cagtagttgg aaaagctcta ttgcctcttt tttctttatc atagggttaa     4500

tcattggact attcttggtt ctccgagttg gtatccatct ttgcattaaa ttaaagcaca     4560

ccaagaaaag acagatttat acagacatag agatgaaccg acttggaaag taactcaaat     4620

cctgcacaac agattcttca tgtttggacc aaatcaactt gtgataccat gctcaaagag     4680

gcctcaatta tatttgagtt tttaattttt atgaaaaaaa ctaacagcaa tcatggaagt     4740

ccacgatttt gagaccgacg agttcaatga tttcaatgaa gatgactatg ccacaagaga     4800

attcctgaat cccgatgagc gcatgacgta cttgaatcat gctgattaca atttgaattc     4860

tcctctaatt agtgatgata ttgacaattt gatcaggaaa ttcaattctc ttccgattcc     4920

ctcgatgtgg gatagtaaga actgggatgg agttcttgag atgttaacat catgtcaagc     4980

caatcccatc tcaacatctc agatgcataa atggatggga agttggttaa tgtctgataa     5040

tcatgatgcc agtcaagggt atagtttttt acatgaagtg gacaaagagg cagaaataac     5100

atttgacgtg gtggagacct tcatccgcgg ctggggcaac aaaccaattg aatacatcaa     5160

aaaggaaaga tggactgact cattcaaaat tctcgcttat ttgtgtcaaa agtttttgga     5220

cttacacaag ttgacattaa tcttaaatgc tgtctctgag gtggaattgc tcaacttggc     5280

gaggactttc aaaggcaaag tcagaagaag ttctcatgga acgaacatat gcaggattag     5340

ggttcccagc ttgggtccta cttttatttc agaaggatgg gcttacttca agaaacttga     5400

tattctaatg gaccgaaact ttctgttaat ggtcaaagat gtgattatag ggaggatgca     5460

aacggtgcta tccatggtat gtagaataga caacctgttc tcagagcaag acatcttctc     5520

ccttctaaat atctacagaa ttggagataa aattgtggag aggcagggaa atttttctta     5580

tgacttgatt aaaatggtgg aaccgatatg caacttgaag ctgatgaaat tagcaagaga     5640

atcaaggcct ttagtcccac aattccctca ttttgaaaat catatcaaga cttctgttga     5700

tgaaggggca aaaattgacc gaggtataag attcctccat gatcagataa tgagtgtgaa     5760

aacagtggat ctcacactgg tgatttatgg atcgttcaga cattggggtc atccttttat     5820

agattattac actggactag aaaaattaca ttcccaagta accatgaaga aagatattga     5880

tgtgtcatat gcaaaagcac ttgcaagtga tttagctcgg attgttctat ttcaacagtt     5940

caatgatcat aaaaagtggt tcgtgaatgg agacttgctc cctcatgatc atccctttaa     6000

aagtcatgtt aaagaaaata catggcccac agctgctcaa gttcaagatt ttggagataa     6060

atggcatgaa cttccgctga ttaaatgttt tgaaataccc gacttactag acccatcgat     6120

aatatactct gacaaaagtc attcaatgaa taggtcagag gtgttgaaac atgtccgaat     6180

gaatccgaac actcctatcc ctagtaaaaa ggtgttgcag actatgttgg acacaaaggc     6240

taccaattgg aaagaatttc ttaaagagat tgatgagaag ggcttagatg atgatgatct     6300

aattattggt cttaaaggaa aggagaggga actgaagttg gcaggtagat ttttctccct     6360

aatgtcttgg aaattgcgag aatactttgt aattaccgaa tatttgataa agactcattt     6420

cgtccctatg tttaaaggcc tgacaatggc ggacgatcta actgcagtca ttaaaaagat     6480

gttagattcc tcatccggcc aaggattgaa gtcatatgag gcaatttgca tagccaatca     6540

cattgattac gaaaaatgga ataaccacca aaggaagtta tcaaacggcc cagtgttccg     6600

agttatgggc cagttcttag gttatccatc cttaatcgag agaactcatg aattttttga     6660

gaaaagtctt atatactaca atggaagacc agacttgatg cgtgttcaca acaacacact     6720

gatcaattca acctcccaac gagtttgttg gcaaggacaa gagggtggac tggaaggtct     6780

acggcaaaaa ggatggacta tcctcaatct actggttatt caaagagagg ctaaaatcag     6840

aaacactgct gtcaaagtct tggcacaagg tgataatcaa gttatttgca cacagtataa     6900

aacgaagaaa tcgagaaacg ttgtagaatt acagggtgct ctcaatcaaa tggtttctaa     6960

taatgagaaa attatgactg caatcaaaat agggacaggg aagttaggac ttttgataaa     7020

tgacgatgag actatgcaat ctgcagatta cttgaattat ggaaaaatac cgattttccg     7080

tggagtgatt agagggttag agaccaagag atggtcacga gtgacttgtg tcaccaatga     7140

ccaaataccc acttgtgcta atataatgag ctcagtttcc acaaatgctc tcaccgtagc     7200

tcattttgct gagaacccaa tcaatgccat gatacagtac aattattttg ggacatttgc     7260

tagactcttg ttgatgatgc atgatcctgc tcttcgtcaa tcattgtatg aagttcaaga     7320

taagataccg ggcttgcaca gttctacttt caaatacgcc atgttgtatt tggacccttc     7380

cattggagga gtgtcgggca tgtctttgtc caggtttttg attagagcct tcccagatcc     7440

cgtaacagaa agtctctcat tctggagatt catccatgta catgctcgaa gtgagcatct     7500

gaaggagatg agtgcagtat ttggaaaccc cgagatagcc aagtttcgaa taactcacat     7560

agacaagcta gtagaagatc caacctctct gaacatcgct atgggaatga gtccagcgaa     7620

cttgttaaag actgaggtta aaaaatgctt aatcgaatca agacaaacca tcaggaacca     7680

ggtgattaag gatgcaacca tatatttgta tcatgaagag gatcggctca gaagtttctt     7740

atggtcaata aatcctctgt tccctagatt tttaagtgaa ttcaaatcag gcactttttt     7800

gggagtcgca gacgggctca tcagtctatt tcaaaattct cgtactattc ggaactcctt     7860

taagaaaaag tatcataggg aattggatga tttgattgtg aggagtgagg tatcctcttt     7920

gacacattta gggaaacttc atttgagaag gggatcatgt aaaatgtgga catgttcagc     7980

tactcatgct gacacattaa gatacaaatc ctggggccgt acagttattg ggacaactgt     8040

accccatcca ttagaaatgt tgggtccaca acatcgaaaa gagactcctt gtgcaccatg     8100

taacacatca gggttcaatt atgtttctgt gcattgtcca gacgggatcc atgacgtctt     8160

tagttcacgg ggaccattgc ctgcttatct agggtctaaa acatctgaat ctacatctat     8220

tttgcagcct tgggaaaggg aaagcaaagt cccactgatt aaaagagcta cacgtcttag     8280

agatgctatc tcttggtttg ttgaacccga ctctaaacta gcaatgacta tactttctaa     8340

catccactct ttaacaggcg aagaatggac caaaaggcag catgggttca aaagaacagg     8400

gtctgccctt cataggtttt cgacatctcg gatgagccat ggtgggttcg catctcagag     8460

cactgcagca ttgaccaggt tgatggcaac tacagacacc atgagggatc tgggagatca     8520

gaatttcgac tttttattcc aagcaacgtt gctctatgct caaattacca ccactgttgc     8580

aagagacgga tggatcacca gttgtacaga tcattatcat attgcctgta agtcctgttt     8640

gagacccata gaagagatca ccctggactc aagtatggac tacacgcccc cagatgtatc     8700

ccatgtgctg aagacatgga ggaatgggga aggttcgtgg ggacaagaga taaaacagat     8760

ctatccttta gaagggaatt ggaagaattt agcacctgct gagcaatcct atcaagtcgg     8820

cagatgtata ggttttctat atggagactt ggcgtataga aaatctactc atgccgagga     8880

cagttctcta tttcctctat ctatacaagg tcgtattaga ggtcgaggtt tcttaaaagg     8940

gttgctagac ggattaatga gagcaagttg ctgccaagta atacaccgga gaagtctggc     9000

tcatttgaag aggccggcca acgcagtgta cggaggtttg atttacttga ttgataaatt     9060

gagtgtatca cctccattcc tttctcttac tagatcagga cctattagag acgaattaga     9120

aacgattccc cacaagatcc caacctccta tccgacaagc aaccgtgata tgggggtgat     9180

tgtcagaaat tacttcaaat accaatgccg tctaattgaa aagggaaaat acagatcaca     9240

ttattcacaa ttatggttat tctcagatgt cttatccata gacttcattg gaccattctc     9300

tatttccacc accctcttgc aaatcctata caagccattt ttatctggga aagataagaa     9360

tgagttgaga gagctggcaa atctttcttc attgctaaga tcaggagagg ggtgggaaga     9420

catacatgtg aaattcttca ccaaggacat attattgtgt ccagaggaaa tcagacatgc     9480

ttgcaagttc gggattgcta aggataataa taaagacatg agctatcccc cttggggaag     9540

ggaatccaga gggacaatta caacaatccc tgtttattat acgaccaccc cttacccaaa     9600

gatgctagag atgcctccaa gaatccaaaa tcccctgctg tccggaatca ggttgggcca     9660

attaccaact ggcgctcatt ataaaattcg gagtatatta catggaatgg gaatccatta     9720

cagggacttc ttgagttgtg gagacggctc cggagggatg actgctgcat tactacgaga     9780

aaatgtgcat agcagaggaa tattcaatag tctgttagaa ttatcagggt cagtcatgcg     9840

aggcgcctct cctgagcccc ccagtgccct agaaacttta ggaggagata aatcgagatg     9900

tgtaaatggt gaaacatgtt gggaatatcc atctgactta tgtgacccaa ggacttggga     9960

ctatttcctc cgactcaaag caggcttggg gcttcaaatt gatttaattg taatggatat    10020

ggaagttcgg gattcttcta ctagcctgaa aattgagacg aatgttagaa attatgtgca    10080

ccggattttg gatgagcaag gagttttaat ctacaagact tatggaacat atatttgtga    10140

gagcgaaaag aatgcagtaa caatccttgg tcccatgttc aagacggtcg acttagttca    10200

aacagaattt agtagttctc aaacgtctga agtatatatg gtatgtaaag gtttgaagaa    10260

attaatcgat gaacccaatc ccgattggtc ttccatcaat gaatcctgga aaaacctgta    10320

cgcattccag tcatcagaac aggaatttgc cagagcaaag aaggttagta catactttac    10380

cttgacaggt attccctccc aattcattcc tgatcctttt gtaaacattg agactatgct    10440

acaaatattc ggagtaccca cgggtgtgtc tcatgcggct gccttaaaat catctgatag    10500

acctgcagat ttattgacca ttagcctttt ttatatggcg attatatcgt attataacat    10560

caatcatatc agagtaggac cgatacctcc gaacccccca tcagatggaa ttgcacaaaa    10620

tgtggggatc gctataactg gtataagctt ttggctgagt ttgatggaga aagacattcc    10680

actatatcaa cagtgtttag cagttatcca gcaatcattc ccgattaggt gggaggctgt    10740

ttcagtaaaa ggaggataca agcagaagtg gagtactaga ggtgatgggc tcccaaaaga    10800

tacccgaact tcagactcct tggccccaat cgggaactgg atcagatctc tggaattggt    10860

ccgaaaccaa gttcgtctaa atccattcaa tgagatcttg ttcaatcagc tatgtcgtac    10920

agtggataat catttgaaat ggtcaaattt gcgaagaaac acaggaatga ttgaatggat    10980

caatagacga atttcaaaag aagaccggtc tatactgatg ttgaagagtg acctacacga    11040

ggaaaactct tggagagatt aaaaaatcat gaggagactc caaactttaa gtatgaaaaa    11100

aactttgatc cttaagaccc tcttgtggtt tttatttttt atctggtttt gtggtcttcg    11160

t                                                                    11161


<210>  2
<211>  1665
<212>  DNA
<213>  Vesicular stomatitis virus

<400>  2
aacagagatc gatctgtttc cttgacacca tgaagtgctt tttgtactta gcttttttat       60

tcatcggggt gaattgcaag ttcaccatag tttttccaca caaccaaaaa ggaaactgga      120

aaaatgttcc ttccaattac cattattgcc cgtcaagctc agatttaaat tggcataatg      180

acttaatagg cacaggctta caagtcaaaa tgcccaagag tcacaaggct attcaagcag      240

acggttggat gtgtcatgct tccaaatggg tcactacttg tgatttccgc tggtacggac      300

cgaagtatat aacacattcc atccgatcct tcactccatc tgtagaacaa tgcaaggaaa      360

gcattgaaca aacgaaacaa ggaacttggc tgaatccagg cttccctcct caaagttgtg      420

gatatgcaac tgtgacggat gccgaagcag tgattgtcca ggtgactcct caccatgtgc      480

ttgttgatga atacacagga gaatgggttg attcacagtt catcaacgga aaatgcagca      540

atgacatatg ccccactgtc cataactcca caacctggca ttccgactat aaggtcaaag      600

ggctatgtga ttctaacctc atttccacgg acatcacctt cttctcagag gacagagagc      660

tatcatccct aggaaaggag ggcacagggt tcagaagtaa ctactttgct tatgaaactg      720

gagacaaggc ctgcaaaatg cagtactgca agcattgggg agtcagactc ccatcaggtg      780

tctggttcga gatggctgat aaggatctct ttgctgcagc cagattccct gaatgcccag      840

aagggtcaag tatctctgct ccatctcaga cctcagtgga tgtaagtctc attcaggacg      900

ttgagaggat cttggattat tccctctgcc aagaaacctg gagcaaaatc agagcgggtc      960

ttcccatctc tccagtggat ctcagctatc ttgctcctaa aaacccagga accggtcctg     1020

cctttaccat aatcaatggt accctaaaat actttgagac cagatacatc agagtcgata     1080

ttgctgctcc aatcctctca agaatggtcg gaatgatcag tggaactacc acagaaaggg     1140

aactgtggga tgactgggct ccatatgaag acgtggaaat tggacccaat ggagttctga     1200

ggaccagttc aggatataag tttcctttat atatgattgg acatggtatg ttggactccg     1260

gtcttcatct tagctcaaag gctcaggtgt ttgaacatcc tcacattcaa gacgctgctt     1320

cgcagcttcc tgatgatgag attttatttt ttggtgatac tgggctatcc aaaaatccaa     1380

tcgactttgt cgaaggttgg ttcagtagtt ggaagagctc cattgcctct tttttcttta     1440

tcatagggtt aatcattgga ctattcttgg ttctccgagt tggtatttat ctttacatta     1500

aattaaagca caccaagaaa agacagattt atacagacat agagatgaac cgacttggaa     1560

ggtaactcaa atcctgcaca acagattctt catgtttgga ccaaatcaac ttgtgatacc     1620

atgctcaaag aggcctcaat tatatttgag tttttaattt ttatg                     1665


<210>  3
<211>  511
<212>  PRT
<213>  Vesicular stomatitis virus

<400>  3

Met Lys Cys Phe Leu Tyr Leu Ala Phe Leu Phe Ile Gly Val Asn Cys 
1               5                   10                  15      


Lys Phe Thr Ile Val Phe Pro His Asn Gln Lys Gly Asn Trp Lys Asn 
            20                  25                  30          


Val Pro Ser Asn Tyr His Tyr Cys Pro Ser Ser Ser Asp Leu Asn Trp 
        35                  40                  45              


His Asn Asp Leu Ile Gly Thr Gly Leu Gln Val Lys Met Pro Lys Ser 
    50                  55                  60                  


His Lys Ala Ile Gln Ala Asp Gly Trp Met Cys His Ala Ser Lys Trp 
65                  70                  75                  80  


Val Thr Thr Cys Asp Phe Arg Trp Tyr Gly Pro Lys Tyr Ile Thr His 
                85                  90                  95      


Ser Ile Arg Ser Phe Thr Pro Ser Val Glu Gln Cys Lys Glu Ser Ile 
            100                 105                 110         


Glu Gln Thr Lys Gln Gly Thr Trp Leu Asn Pro Gly Phe Pro Pro Gln 
        115                 120                 125             


Ser Cys Gly Tyr Ala Thr Val Thr Asp Ala Glu Ala Val Ile Val Gln 
    130                 135                 140                 


Val Thr Pro His His Val Leu Val Asp Glu Tyr Thr Gly Glu Trp Val 
145                 150                 155                 160 


Asp Ser Gln Phe Ile Asn Gly Lys Cys Ser Asn Asp Ile Cys Pro Thr 
                165                 170                 175     


Val His Asn Ser Thr Thr Trp His Ser Asp Tyr Lys Val Lys Gly Leu 
            180                 185                 190         


Cys Asp Ser Asn Leu Ile Ser Thr Asp Ile Thr Phe Phe Ser Glu Asp 
        195                 200                 205             


Arg Glu Leu Ser Ser Leu Gly Lys Glu Gly Thr Gly Phe Arg Ser Asn 
    210                 215                 220                 


Tyr Phe Ala Tyr Glu Thr Gly Asp Lys Ala Cys Lys Met Gln Tyr Cys 
225                 230                 235                 240 


Lys His Trp Gly Val Arg Leu Pro Ser Gly Val Trp Phe Glu Met Ala 
                245                 250                 255     


Asp Lys Asp Leu Phe Ala Ala Ala Arg Phe Pro Glu Cys Pro Glu Gly 
            260                 265                 270         


Ser Ser Ile Ser Ala Pro Ser Gln Thr Ser Val Asp Val Ser Leu Ile 
        275                 280                 285             


Gln Asp Val Glu Arg Ile Leu Asp Tyr Ser Leu Cys Gln Glu Thr Trp 
    290                 295                 300                 


Ser Lys Ile Arg Ala Gly Leu Pro Ile Ser Pro Val Asp Leu Ser Tyr 
305                 310                 315                 320 


Leu Ala Pro Lys Asn Pro Gly Thr Gly Pro Ala Phe Thr Ile Ile Asn 
                325                 330                 335     


Gly Thr Leu Lys Tyr Phe Glu Thr Arg Tyr Ile Arg Val Asp Ile Ala 
            340                 345                 350         


Ala Pro Ile Leu Ser Arg Met Val Gly Met Ile Ser Gly Thr Thr Thr 
        355                 360                 365             


Glu Arg Glu Leu Trp Asp Asp Trp Ala Pro Tyr Glu Asp Val Glu Ile 
    370                 375                 380                 


Gly Pro Asn Gly Val Leu Arg Thr Ser Ser Gly Tyr Lys Phe Pro Leu 
385                 390                 395                 400 


Tyr Met Ile Gly His Gly Met Leu Asp Ser Gly Leu His Leu Ser Ser 
                405                 410                 415     


Lys Ala Gln Val Phe Glu His Pro His Ile Gln Asp Ala Ala Ser Gln 
            420                 425                 430         


Leu Pro Asp Asp Glu Ile Leu Phe Phe Gly Asp Thr Gly Leu Ser Lys 
        435                 440                 445             


Asn Pro Ile Asp Phe Val Glu Gly Trp Phe Ser Ser Trp Lys Ser Ser 
    450                 455                 460                 


Ile Ala Ser Phe Phe Phe Ile Ile Gly Leu Ile Ile Gly Leu Phe Leu 
465                 470                 475                 480 


Val Leu Arg Val Gly Ile Tyr Leu Tyr Ile Lys Leu Lys His Thr Lys 
                485                 490                 495     


Lys Arg Gln Ile Tyr Thr Asp Ile Glu Met Asn Arg Leu Gly Arg 
            500                 505                 510     


<210>  4
<211>  15186
<212>  DNA
<213>  Newcastle disease virus

<400>  4
accaaacaga gaatccgtaa gttacgataa aaggcgaagg agcaattgaa gtcgcacggg       60

tagaaggtgt gaatctcgag tgcgagcccg aagcacaaac tcgaggaagc cttctgccaa      120

catgtcttcc gtattcgacg agtacgaaca gctcctcgcg gctcagactc gccccaatgg      180

agctcatgga gggggggaga aagggagtac cttaaaagta gacgtcccgg tattcactct      240

taacagtgat gacccagaag ataggtggag ctttgtggta ttctgcctcc ggattgctgt      300

tagcgaagat gccaacaaac cactcaggca aggtgctctc atatctcttt tatgctccca      360

ctcacaggta atgaggaacc atgttgccct tgcagggaaa cagaatgaag ccacattggc      420

cgtgcttgag attgatggct ttgccaacgg cacgccccag ttcaacaata ggagtggagt      480

gtctgaagag agagcacaga gatttgcgat gatagcagga tctctccctc gggcatgcag      540

caacggcacc ccgttcgtca cagccggggc tgaagatgat gcaccagaag acatcaccga      600

taccctggag aggatcctct ctatccaggc tcaagtatgg gtcacagtag caaaagccat      660

gactgcgtat gagactgcag atgagtcgga aacaaggcga atcaataagt atatgcagca      720

aggcagggtc caaaagaaat acatcctcta ccccgtatgc aggagcacaa tccaactcac      780

gatcagacag tctcttgcag tccgcatctt tttggttagc gagctcaaga gaggccgcaa      840

cacggcaggt ggtacctcta cttattataa cctagtaggg gacgtagact catatatcag      900

gaataccggg cttactgcat tcttcttgac actcaagtac ggaatcaaca ccaagacatc      960

agcccttgca cttagtagcc tctcaggcga catccagaag atgaagcagc tcatgcgttt     1020

gtatcggatg aaaggagata atgcgccgta catgacatta cttggtgata gtgaccagat     1080

gagctttgcg cctgccgagt atgcacaact ttactccttt gccatgggta tggcatcagt     1140

cctagataaa ggtactggga aataccaatt tgccagggac tttatgagca catcattctg     1200

gagacttgga gtagagtacg ctcaggctca gggaagtagc attaacgagg atatggctgc     1260

cgagctaaag ctaaccccgg cagcaaggag gggcctggca gctgctgccc aacgagtctc     1320

cgaggtgacc agcagcatag acatgcctac tcaacaagtc ggagtcctca ctgggcttag     1380

cgagggggga tcccaagccc tacaaggcgg atcgaataga tcgcaagggc aaccagaagc     1440

cggggatggg gagacccaat tcctggatct gatgagagcg gtagcaaata gcatgaggga     1500

ggcgccaaac tctgcacagg gcactcccca atcggggcct cccccaactc ctgggccatc     1560

ccaagataac gacaccgact gggggtattg attgacaaaa cccagcctgc ttctacaaga     1620

acatcccaat gctctcaccc gtagtcgacc cctcgatttg cggctctata tgaccacacc     1680

ctcaaacaaa catccccctc tttcctccct ccccctgctg tacaactccg cacgccctag     1740

ataccacagg cacaccgcgg ctcactaaca atcaaaacag agccgaggga attagaaaaa     1800

agtacgggta gaagagggat attcagagat cagggcaagt ctcccgagtc tctgctctct     1860

cctctacctg atagaccagg acaaacatgg ccacctttac agatgcagag atcgacgagc     1920

tatttgagac aagtggaact gtcattgaca acataattac agcccagggt aaaccagcag     1980

agactgttgg aaggagtgca atcccacagg gcaagaccaa ggtgctgagc gcagcatggg     2040

agaagcatgg gagcatccag ccaccggcca gtcaagacaa cctcgatcga caggacagat     2100

ctgacaaaca accatccaca cccgagcaaa cgaccccgca cgacagcccg ccggccacat     2160

ccgctgacca gccccccacc caggccacag acgaagccgt cgacacacag ctcaggaccg     2220

gagcaagcaa ctctctgctg ttgatgcttg acaagctcag caataaatcg tccaatgcta     2280

aaaagggccc atggtcgagc ccccaagagg ggaatcacca acgtccgact caacagcagg     2340

ggagtcaacc cagtcgcgga aacagccagg aaagactgca gaaccaagtc aaggccgccc     2400

ctggaaacca gggcacagac gtgaacacag catatcatgg acaatgggag gagtcacaac     2460

tatcagctgg tgcaacccct catgctctcc gatcaaggca gagccaagac aatacccttg     2520

tatctgcgga tcatgtccag ccacctgtag actttgtgca agcgatgatg tctatgatgg     2580

gggcgatatc acagagagta agtaaggttg actatcagct agatcttgtc ttgaaacaga     2640

catcctccat ccctatgatg cggtccgaaa tccaacagct gaaaacatct gttgcagtca     2700

tggaagccaa cttgggaatg atgaagattc tggatcccgg ttgtgccaac atttcatctc     2760

tgagtgatct acgggcagtt gcccgatctc acccggtttt agtttcaggc cctggagacc     2820

catctcccta tgtgatacaa ggaggcgaaa tggcacttaa taaactttcg caaccagtgc     2880

cacatccatc tgaattgatt aaacccgcca ctgcatgcgg gcctgatata ggagtggaga     2940

gggacactgt ccgtgcattg atcatgtcac gcccaatgca cccgagttct tcagccaagc     3000

tcctaagcaa gttagatgca gccgggtcga tcgaggaaat caggaaaatc aagcgccttg     3060

ctctaaatgg ctaattacta ctgccacacg tagcgggtcc ctgtccactc ggcatcacac     3120

ggaatctgca ccgagttccc ccccgcagac ccaaggtcca actctagaag cggcaatcct     3180

ctctcgcttc ctcagcccca ctgaatgatc gcgtaaccgt aattaatcta gctacattaa     3240

ggattaagaa aaaatacggg tagaattgga gtgccccaat tgtgccaaga tggactcatc     3300

taggacaatt gggctgtact ttgattctgc ccattcttct agcaacctgt tagcatttcc     3360

gatcgtccta caagacacag gagatgggaa gaagcaaatc gccccgcaat ataggatcca     3420

gcgccttgac tcgtggactg atagtaagga agactcagta ttcatcacca cctatggatt     3480

catctttcaa gttgggaatg aggaagccac tgtcggcatg atcgatgata aacccaagcg     3540

cgagttactt tccgctgcga tgctctgcct aggaagcgtc ccaaataccg gagaccttgt     3600

tgagctggca agggcctgtc tcactatgat ggtcacatgc aagaagagtg caactaatac     3660

tgagagaatg gttttctcag tagtgcaggc accccaagtg ctgcaaagct gtagggttgt     3720

ggcaaataaa tactcatcag tgaatgcagt caagcacgtg aaagcgccag agaagatccc     3780

cgggagtgga accctagaat acaaggtgaa ctttgtctcc ttgactgtgg taccgaagaa     3840

ggatgtctac aagatcccag ctgcagtatt gaagatttct ggctcgagtc tgtacaatct     3900

tgcgctcaat gtcactatta atgtggaggt agacccgagg agtcctttgg ttaaatctct     3960

gtctaagtct gacagcggat actatgctaa cctcttcttg catattggac ttatgaccac     4020

cgtagatagg aaggggaaga aagtgacatt tgacaagctg gaaaagaaaa taaggagcct     4080

tgatctatct gtcgggctca gtgatgtgct cgggccttcc gtgttggtaa aagcaagagg     4140

tgcacggact aagcttttgg cacctttctt ctctagcagt gggacagcct gctatcccat     4200

agcaaatgct tctcctcagg tggccaagat actctggagt caaaccgcgt gcctgcggag     4260

cgttaaaatc attatccaag caggtaccca acgcgctgtc gcagtgaccg ctgaccacga     4320

ggttacctct actaagctgg agaaggggca cacccttgcc aaatacaatc cttttaagaa     4380

ataagctgcg tctctgagat tgcgctccgc ccactcaccc agatcatcat gacacaaaaa     4440

actaatctgt cttgattatt tacagttagt ttacctgtcc atcaagttag aaaaaacacg     4500

ggtagaagat tctggatccc ggttggcgcc ctccaggtgc aggatgggct ccagaccttc     4560

taccaagaac ccagcaccta tgatgctgac tatccgggtc gcgctggtac tgagttgcat     4620

ctgcccggca aactccattg atggcaggcc tcttgcagct gcaggaattg tggttacagg     4680

agacaaagca gtcaacatat acacctcatc ccagacagga tcaatcatag ttaagctcct     4740

cccgaatctg cccaaggata aggaggcatg tgcgaaagcc cccttggatg catacaacag     4800

gacattgacc actttgctca ccccccttgg tgactctatc cgtaggatac aagagtctgt     4860

gactacatct ggagggggga gacaggggcg ccttataggc gccattattg gcggtgtggc     4920

tcttggggtt gcaactgccg cacaaataac agcggccgca gctctgatac aagccaaaca     4980

aaatgctgcc aacatcctcc gacttaaaga gagcattgcc gcaaccaatg aggctgtgca     5040

tgaggtcact gacggattat cgcaactagc agtggcagtt gggaagatgc agcagtttgt     5100

taatgaccaa tttaataaaa cagctcagga attagactgc atcaaaattg cacagcaagt     5160

tggtgtagag ctcaacctgt acctaaccga attgactaca gtattcggac cacaaatcac     5220

ttcacctgcc ttaaacaagc tgactattca ggcactttac aatctagctg gtgggaatat     5280

ggattactta ttgactaagt taggtatagg gaacaatcaa ctcagctcat taatcggtag     5340

cggcttaatc accggtaacc ctattctata cgactcacag actcaactct tgggtataca     5400

ggtaactcta ccttcagtcg ggaacctaaa taatatgcgt gccacctact tggaaacctt     5460

atccgtaagc acaaccaggg gatttgcctc ggcacttgtc ccaaaagtgg tgacacaggt     5520

cggttctgtg atagaagaac ttgacacctc atactgtata gaaactgact tagatttata     5580

ttgtacaaga atagtaacgt tccctatgtc ccctggtatt tactcctgct tgagcggcaa     5640

tacatcggcc tgtatgtact caaagaccga aggcgcactt actacaccat atatgactat     5700

caaaggctca gtcatcgcta actgcaagat gacaacatgt agatgtgtaa accccccggg     5760

tatcatatcg caaaactatg gagaagccgt gtctctaata gataaacaat catgcaatgt     5820

tttatcctta ggcgggataa ctttaaggct cagtggggaa ttcgatgtaa cttatcagaa     5880

gaatatctca atacaagatt ctcaagtaat aataacaggc aatcttgata tctcaactga     5940

gcttgggaat gtcaacaact cgatcagtaa tgctttgaat aagttagagg aaagcaacag     6000

aaaactagac aaagtcaatg tcaaactgac cagcacatct gctctcatta cctatatcgt     6060

tttgactatc atatctcttg tttttggtat acttagcctg attctagcat gctacctaat     6120

gtacaagcaa aaggcgcaac aaaagacctt attatggctt gggaataata ccctagatca     6180

gatgagagcc actacaaaaa tgtgaacaca gatgaggaac gaaggtttcc ctaatagtaa     6240

tttgtgtgaa agttctggta gtctgtcagt tcggagagtt aagaaaaaac taccggttgt     6300

agatgaccaa aggacgatat acgggtagaa cggtaagaga ggccgcccct caattgcgag     6360

ccagacttca caacctccgt tctaccgctt caccgacaac agtcctcaat catggaccgc     6420

gccgttagcc aagttgcgtt agagaatgat gaaagagagg caaaaaatac atggcgcttg     6480

atattccgga ttgcaatctt attcttaaca gtagtgacct tggctatatc tgtagcctcc     6540

cttttatata gcatgggggc tagcacacct agcgatcttg taggcatacc gactaggatt     6600

tccagggcag aagaaaagat tacatctaca cttggttcca atcaagatgt agtagatagg     6660

atatataagc aagtggccct tgagtctcca ttggcattgt taaatactga gaccacaatt     6720

atgaacgcaa taacatctct ctcttatcag attaatggag ctgcaaacaa cagcgggtgg     6780

ggggcaccta ttcatgaccc agattatata ggggggatag gcaaagaact cattgtagat     6840

gatgctagtg atgtcacatc attctatccc tctgcatttc aagaacatct gaattttatc     6900

ccggcgccta ctacaggatc aggttgcact cgaataccct catttgacat gagtgctacc     6960

cattactgct acacccataa tgtaatattg tctggatgca gagatcactc acactcacat     7020

cagtatttag cacttggtgt gctccggaca tctgcaacag ggagggtatt cttttctact     7080

ctgcgttcca tcaacctgga cgacacccaa aatcggaagt cttgcagtgt gagtgcaact     7140

cccctgggtt gtgatatgct gtgctcgaaa gccacggaga cagaggaaga agattataac     7200

tcagctgtcc ctacgcggat ggtacatggg aggttagggt tcgacggcca atatcacgaa     7260

aaggacctag atgtcacaac attattcggg gactgggtgg ccaactaccc aggagtaggg     7320

ggtggatctt ttattgacag ccgcgtatgg ttctcagtct acggagggtt aaaacccaat     7380

acacccagtg acactgtaca ggaagggaaa tatgtgatat acaagcgata caatgacaca     7440

tgcccagatg agcaagacta ccagattcga atggccaagt cttcgtataa gcctggacgg     7500

tttggtggga aacgcataca gcaggctatc ttatctatca aagtgtcaac atccttaggc     7560

gaagacccgg tactgactgt accgcccaac acagtcacac tcatgggggc cgaaggcaga     7620

attctcacag tagggacatc ccatttcttg tatcagcgag ggtcatcata cttctctccc     7680

gcgttattat atcctatgac agtcagcgac aaaacagcca ctcttcatag tccttataca     7740

ttcaatgcct tcactcggcc aggtagtatc ccttgccagg cttcagcaag atgccccaac     7800

tcgtgtgtta ctggagtcta tacagatcca tatcccctaa tcttctatag aaaccacacc     7860

ttgcgagggg tattcgggac aatgcttgat ggtgaacaag caagacttaa ccctgcgtct     7920

gcagtattcg atagcacatc ccgcagtcgc ataactcgag tgagttcaag cagcatcaaa     7980

gcagcataca caacatcaac ttgttttaaa gtggtcaaga ccaataagac ctattgtctc     8040

agcattgctg aaatatctaa tactctcttc ggagaattca gaatcgtccc gttactagtt     8100

gagatcctca aagatgacgg ggttagagaa gccaggtctg gctagttgag tcaactatga     8160

aagagttgga aagatggcat tgtatcacct atcttctgcg acatcaagaa tcaaaccgaa     8220

tgccggcgcg tgctcgaatt ccatgtcgcc agttgaccac aatcagccag tgctcatgcg     8280

atcagattaa gccttgtcaa tagtctcttg attaagaaaa aatgtaagtg gcaatgagat     8340

acaaggcaaa acagctcacg gtaaataata cgggtaggac atggcgagct ccggtcctga     8400

aagggcagag catcagatta tcctaccaga gtcacacctg tcttcaccat tggtcaagca     8460

caaactactc tattattgga aattaactgg gctaccgctt cctgatgaat gtgacttcga     8520

ccacctcatt ctcagccgac aatggaaaaa aatacttgaa tcggcctctc ctgatactga     8580

gagaatgata aaactcggaa gggcagtaca ccaaactctt aaccacaatt ccagaataac     8640

cggagtactc caccccaggt gtttagaaga actggctaat attgaggtcc ctgattcaac     8700

caacaaattt cggaagattg agaagaagat ccaaattcac aacacgagat atggagaact     8760

gttcacaagg ctgtgtacgc atatagagaa gaaactgctg gggtcatctt ggtctaacaa     8820

tgtcccccgg tcagaggagt tcagcagcat tcgtacggat ccggcattct ggtttcactc     8880

aaaatggtcc acagccaagt ttgcatggct ccatataaaa cagatccaga ggcatctgat     8940

tgtggcagct aggacaaggt ctgcggccaa caaattggtg atgctaaccc ataaggtagg     9000

ccaagtcttt gtcactcctg aacttgttgt tgtgacgcat acgaatgaga acaagttcac     9060

atgtcttacc caggaacttg tattgatgta tgcagatatg atggagggca gagatatggt     9120

caacataata tcaaccacgg cggtgcatct cagaagctta tcagagaaaa ttgatgacat     9180

tttgcggtta atagacgctc tggcaaaaga cttgggtaat caagtctacg atgttgtatc     9240

actaatggag ggatttgcat acggagctgt ccagctactc gagccgtcag gtacatttgc     9300

gggagatttc ttcgcattca acctgcagga gcttaaagac attctaattg gcctcctccc     9360

caatgatata gcagaatccg tgactcatgc aatcgctact gtattctctg gtttagaaca     9420

gaatcaagca gctgagatgt tgtgcctgtt gcgtctgtgg ggtcacccac tgcttgagtc     9480

ccgtattgca gcaaaggcag tcaggagcca aatgtgcgca ccgaaaatgg tagactttga     9540

tatgatcctt caggtactgt ctttcttcaa gggaacaatc atcaacggat acagaaagaa     9600

gaatgcaggt gtgtggccgc gagtcaaagt ggatacaata tatgggaagg tcattgggca     9660

actacatgca gattcagcag agatttcaca cgatatcatg ttgagagagt ataagagttt     9720

atctgcactt gaatttgagc catgtataga atacgaccct gtcactaacc tgagcatgtt     9780

cctaaaagac aaggcaatcg cacaccccaa cgataattgg cttgcctcgt ttaggcggaa     9840

ccttctctcc gaagaccaga agaaacatgt aaaggaagcg acttcgacta accgcctctt     9900

gatagagttt ttagagtcaa atgattttga tccatataaa gagatggaat atctgacgac     9960

ccttgagtac cttagagatg acaatgtggc agtatcatac tcgctcaaag agaaggaagt    10020

gaaagttaat ggacggatct tcgctaagct gacaaagaag ttaaggaact gtcaggtgat    10080

ggcggaaggg atcctagccg atcagattgc acctttcttt cagggaaatg gagtcattca    10140

ggatagcata tccttgacca agagtatgct agcgatgagt caactgtctt ttaacagcaa    10200

taagaaacgt atcactgact gtaaagaaag agtatgttca aaccgcaatc atgatccgaa    10260

aagcaagaac cgtcggagag ttgcaacctt cataacaact gacctgcaaa agtactgtct    10320

taattggaga tatcagacga tcaaattgtt cgctcatgcc atcaatcagt tgatgggcct    10380

acctcatttc ttcgagtgga ttcacctaag actgatggac actacgatgt tcgtaggaga    10440

ccctttcaat cctccaagtg accctactga ctgtgacctc tcaagagtcc ctaatgatga    10500

catatatatt gtcagtgcca gagggggtat cgaaggatta tgccagaagc tatggacaat    10560

gatctcaatt gctgcaatcc aacttgctgc agctagatcg cattgtcgtg ttgcctgtat    10620

ggtacagggt gataatcaag taatagcagt aacgagagag gtaagatcag atgactctcc    10680

ggagatggtg ttgacacagt tgcatcaagc cagtgataat ttcttcaagg aattaatcca    10740

tgtcaatcat ttgattggcc ataatttgaa ggatcgtgaa accatcaggt cagacacatt    10800

cttcatatac agcaaacgaa tcttcaaaga tggagcaatc ctcagtcaag tcctcaaaaa    10860

ttcatctaaa ttagtgctag tgtcaggtga tctcagtgaa aacaccgtaa tgtcctgtgc    10920

caacattgcc tctactgtag cacggctatg cgagaacggg cttcccaaag acttctgtta    10980

ctatttaaac tatataatga gttgtgtgca gacatacttt gactctgagt tctccatcac    11040

caacaattcg caccccgatc ttaatcagtc gtggattgag gacatctctt ttgtgcactc    11100

atatgttctg actcctgccc aattaggggg actgagtaac cttcaatact caaggctcta    11160

cactagaaat atcggtgacc cggggactac tgcttttgca gagatcaagc gactagaagc    11220

agtgggacta ctgagtccta acattaggac taatatctta actaggccgc ctgggaatgg    11280

agattgggcc agtctgtgca acgacccata ctctttcaat tttgagactg ttgcaagccc    11340

aaacattgtt cttaagaaac atacgcaaag agtcctattt gaaacttgtt caaatccctt    11400

attgtctgga gtgcacacag aggataatga ggcagaagag aaggcattgg ctgaattctt    11460

gcttaatcaa gaggtgattc atccccgcgt tgcgcatgcc atcatggagg caagctctgt    11520

aggtaggaga aagcaaattc aagggcttgt tgacacaaca aacactgtaa ttaagattgc    11580

gcttactagg aggccattag gcatcaagag gctgatgcgg atagtcaatt attctagcat    11640

gcatgcaatg ctgtttagag acgatgtttt ttcctctagt agatccaacc accccttagt    11700

ctcttctaat atgtgttctc tgacactggc agactatgca cggaatagaa gctggtcacc    11760

tttgacggga ggcaggaaaa tactgggtgt atctaatcct gatacgatag aactcgtaga    11820

gggtgagatt cttagtgtaa gcggagggtg tacaagatgt gacagcggag atgaacaatt    11880

tacttggttc catcttccaa gcaatataga attgaccgat gacaccagca agaatcctcc    11940

gatgagggta ccatatctcg ggtcaaagac acaggagagg agagctgcct cacttgcgaa    12000

aatagctcat atgtcgccac atgtgaaggc tgccctaagg gcatcatccg tgttgatctg    12060

ggcttatggg gataatgaag taaattggac tgctgctctt acgattgcaa aatctcggtg    12120

taatgtaaac ttagagtatc ttcggttact gtccccttta cccacggctg ggaatcttca    12180

acatagacta gatgatggta taactcagat gacattcacc cctgcatctc tctacagggt    12240

gtcaccttac attcacatat ccaatgattc tcaaaggctg ttcactgaag aaggagtcaa    12300

agaggggaat gtggtttacc aacagatcat gctcttgggt ttatctctaa tcgaatcgat    12360

ctttccaatg acaacaacca gaacatatga tgagatcaca ctgcacctac atagtaaatt    12420

tagttgctgt atcagggaag cacctgttgc ggttcctttc gagctacttg gggtggcacc    12480

ggaactgagg acagtgacct caaataagtt tatgtatgat cctagccctg tatcggaggg    12540

agactttgcg agacttgact tagctatctt caagagttat gagcttaatc tggagtcata    12600

tcccacgata gagctaatga acattctttc aatatccagc gggaagttga ttggccagtc    12660

tgtggtttct tatgatgaag atacctccat aaagaatgat gccataatag tgtatgacaa    12720

tacccgaaat tggatcagtg aagctcagaa ttcagatgtg gtccgcctat ttgaatatgc    12780

agcacttgaa gtgctcctcg actgttctta ccaactctat tacctgagag taagagacct    12840

agacaatatt gtcttatata tgggtgattt atacaagaat atgccaggaa ttctactttc    12900

caacattgca gctacaatat ctcatcctgt cattcattca aggttacatg cagtgggcct    12960

ggtcaaccat gacggatcac accaacttgc agatacggat tttatcgaaa tgtctgcaaa    13020

actgttagta tcttgcaccc gacgtgtgat ctccggctta tattcaggaa ataagtatga    13080

tctgctgttc ccatctgtct tagatgataa cctgaatgag aagatgcttc agctgatatc    13140

ccggttatgc tgtctgtaca cggtactctt tgctacaaca agagaaatcc cgaaaataag    13200

aggcttaact gcagaagaga aatgttcaat actcactgag tatttactgt cggatgctgt    13260

gaaaccatta cttagccccg atcaagtgag ctctatcatg tctcctaaca taattacatt    13320

cccagctaat ctgtactaca tgtctcggaa gagcctcaat ttgatcaggg aaagggagga    13380

cagggatact atcctggcgt tgttgttccc ccaagagcca ttattagagt tcccttctgt    13440

gcaagatatt ggtgctcgag tgaaagatcc attcacccga caacctgcgg catttttgca    13500

agagttagat ttgagtgctc cagcaaggta tgacgcattc acacttagtc agattcatcc    13560

tgaactcaca tctccaaatc cggaggaaga ctacttagta cgatacttgt tcagagggat    13620

agggactgca tcttcctctt ggtataaggc atcccatctc ctttctgtac ccgaggtaag    13680

atgtgcaaga cacgggaact ccttatactt ggctgaagga agcggagcca tcatgagtct    13740

tcttgaactg catgtaccac atgaaactat ctattacaat acgctctttt caaatgagat    13800

gaaccccccg caacgacatt tcgggccgac cccaactcag tttttgaatt cggttgttta    13860

taggaatcta caggcggagg taacatgcaa ggatggattt gtccaagagt tccgtccatt    13920

atggagagaa aatacagagg aaagtgacct gacctcagat aaagcagtgg ggtatattac    13980

atctgcagta ccctacagat ctgtatcatt gctgcattgt gacattgaaa ttcctccagg    14040

gtccaatcaa agcttactag atcaactagc tatcaattta tctctgattg ccatgcattc    14100

tgtaagggag ggcggggtag taatcatcaa agtgttgtat gcaatgggat actactttca    14160

tctactcatg aacttgtttg ctccgtgttc cacaaaagga tatattctct ctaatggtta    14220

tgcatgtcga ggggatatgg agtgttacct ggtatttgtc atgggttacc tgggcgggcc    14280

tacatttgta catgaggtgg tgaggatggc aaaaactctg gtgcagcggc acggtacgct    14340

tttgtctaaa tcagatgaga tcacactgac caggttattc acctcacagc ggcagcgtgt    14400

gacagacatc ctatccagtc ctttaccaag attaataaag tacttgagga agaatattga    14460

cactgcgctg attgaagccg ggggacagcc cgtccgtcca ttctgtgcgg agagtctggt    14520

gagcacgcta gcgaacataa ctcagataac ccagatcatc gctagtcaca ttgacacagt    14580

catccggtct gtgatatata tggaagctga gggtgatctc gctgacacag tatttctatt    14640

taccccttac aatctctcta ctgacgggaa aaagaggaca tcacttaaac agtgcacgag    14700

acagatccta gaggttacaa tactaggtct tagagtcgaa aatctcaata aaataggcga    14760

tataatcagc ctagtgctta aaggcatgat ctccatggag gaccttatcc cactaaggac    14820

atacttgaag catagtacct gccctaaata tttgaaggct gtcctaggta ttaccaaact    14880

caaagaaatg tttacagaca cttctgtact gtacttgact cgtgctcaac aaaaattcta    14940

catgaaaact ataggcaatg cagtcaaagg atattacagt aactgtgact cctaacgaaa    15000

atcacatatt aataggctcc ttttttggcc aattgtattc ttgttgattt aattatatta    15060

tgttagaaaa aagttgaact ctgactcctt aggactcgaa ttcgaactca aataaatgtc    15120

tttaaaaaag gttgcgcaca attattcttg agtgtagtct cgtcattcac caaatctttg    15180

tttggt                                                               15186


<210>  5
<211>  1992
<212>  DNA
<213>  Newcastle disease virus

<400>  5
acgggtagaa cggtaagaga ggccgcccct caattgcgag ccagacttca caacctccgt       60

tctaccgctt caccgacaac agtcctcaat catggaccgc gccgttagcc aagttgcgtt      120

agagaatgat gaaagagagg caaaaaatac atggcgcttg atattccgga ttgcaatctt      180

attcttaaca gtagtgacct tggctatatc tgtagcctcc cttttatata gcatgggggc      240

tagcacacct agcgatcttg taggcatacc gactaggatt tccagggcag aagaaaagat      300

tacatctaca cttggttcca atcaagatgt agtagatagg atatataagc aagtggccct      360

tgagtctcca ttggcattgt taaatactga gaccacaatt atgaacgcaa taacatctct      420

ctcttatcag attaatggag ctgcaaacaa cagcgggtgg ggggcaccta ttcatgaccc      480

agattatata ggggggatag gcaaagaact cattgtagat gatgctagtg atgtcacatc      540

attctatccc tctgcatttc aagaacatct gaattttatc ccggcgccta ctacaggatc      600

aggttgcact cgaataccct catttgacat gagtgctacc cattactgct acacccataa      660

tgtaatattg tctggatgca gagatcactc acactcatat cagtatttag cacttggtgt      720

gctccggaca tctgcaacag ggagggtatt cttttctact ctgcgttcca tcaacctgga      780

cgacacccaa aatcggaagt cttgcagtgt gagtgcaact cccctgggtt gtgatatgct      840

gtgctcgaaa gccacggaga cagaggaaga agattataac tcagctgtcc ctacgcggat      900

ggtacatggg aggttagggt tcgacggcca atatcacgaa aaggacctag atgtcacaac      960

attattcggg gactgggtgg ccaactaccc aggagtaggg ggtggatctt ttattgacag     1020

ccgcgtatgg ttctcagtct acggagggtt aaaacccaat tcacccagtg acactgtaca     1080

ggaagggaaa tatgtgatat acaagcgata caatgacaca tgcccagatg agcaagacta     1140

ccagattcga atggccaagt cttcgtataa gcctggacgg tttggtggga aacgcataca     1200

gcaggctatc ttatctatca aagtgtcaac atccttaggc gaagacccgg tactgactgt     1260

accgcccaac acagtcacac tcatgggggc cgaaggcaga attctcacag tagggacatc     1320

ccatttcttg tatcagcgag ggtcatcata cttctctccc gcgttattat atcctatgac     1380

agtcagcaac aaaacagcca ctcttcatag tccttataca ttcaatgcct tcactcggcc     1440

aggtagtatc ccttgccagg cttcagcaag atgccccaac tcgtgtgtta ctggagtcta     1500

tacagatcca tatcccctaa tcttctatag aaaccacacc ttgcgagggg tattcgggac     1560

aatgcttgat ggtgaacaag caagacttaa ccctgcgtct gcagtattcg atagcacatc     1620

ccgcagtcgc ataactcgag tgagttcaag cagcatcaaa gcagcataca caacatcaac     1680

ttgttttaaa gtggtcaaga ccaataagac ctattgtctc agcattgctg aaatatctaa     1740

tactctcttc ggagaattca gaatcgtccc gttactagtt gagatcctca aagatgacgg     1800

ggttagagaa gccaggtctg gctagttgag tcaactatga aagagttgga aagatggcat     1860

tgtatcacct atcttctgcg acatcaagaa tcaaaccgaa tgccggcgcg tgctcgaatt     1920

ccatgtcgcc agttgaccac aatcagccag tgctcatgcg atcagattaa gccttgtcaa     1980

tagtctcttg at                                                         1992


<210>  6
<211>  577
<212>  PRT
<213>  Newcastle disease virus

<400>  6

Met Asp Arg Ala Val Ser Gln Val Ala Leu Glu Asn Asp Glu Arg Glu 
1               5                   10                  15      


Ala Lys Asn Thr Trp Arg Leu Ile Phe Arg Ile Ala Ile Leu Phe Leu 
            20                  25                  30          


Thr Val Val Thr Leu Ala Ile Ser Val Ala Ser Leu Leu Tyr Ser Met 
        35                  40                  45              


Gly Ala Ser Thr Pro Ser Asp Leu Val Gly Ile Pro Thr Arg Ile Ser 
    50                  55                  60                  


Arg Ala Glu Glu Lys Ile Thr Ser Thr Leu Gly Ser Asn Gln Asp Val 
65                  70                  75                  80  


Val Asp Arg Ile Tyr Lys Gln Val Ala Leu Glu Ser Pro Leu Ala Leu 
                85                  90                  95      


Leu Asn Thr Glu Thr Thr Ile Met Asn Ala Ile Thr Ser Leu Ser Tyr 
            100                 105                 110         


Gln Ile Asn Gly Ala Ala Asn Asn Ser Gly Trp Gly Ala Pro Ile His 
        115                 120                 125             


Asp Pro Asp Tyr Ile Gly Gly Ile Gly Lys Glu Leu Ile Val Asp Asp 
    130                 135                 140                 


Ala Ser Asp Val Thr Ser Phe Tyr Pro Ser Ala Phe Gln Glu His Leu 
145                 150                 155                 160 


Asn Phe Ile Pro Ala Pro Thr Thr Gly Ser Gly Cys Thr Arg Ile Pro 
                165                 170                 175     


Ser Phe Asp Met Ser Ala Thr His Tyr Cys Tyr Thr His Asn Val Ile 
            180                 185                 190         


Leu Ser Gly Cys Arg Asp His Ser His Ser His Gln Tyr Leu Ala Leu 
        195                 200                 205             


Gly Val Leu Arg Thr Ser Ala Thr Gly Arg Val Phe Phe Ser Thr Leu 
    210                 215                 220                 


Arg Ser Ile Asn Leu Asp Asp Thr Gln Asn Arg Lys Ser Cys Ser Val 
225                 230                 235                 240 


Ser Ala Thr Pro Leu Gly Cys Asp Met Leu Cys Ser Lys Ala Thr Glu 
                245                 250                 255     


Thr Glu Glu Glu Asp Tyr Asn Ser Ala Val Pro Thr Arg Met Val His 
            260                 265                 270         


Gly Arg Leu Gly Phe Asp Gly Gln Tyr His Glu Lys Asp Leu Asp Val 
        275                 280                 285             


Thr Thr Leu Phe Gly Asp Trp Val Ala Asn Tyr Pro Gly Val Gly Gly 
    290                 295                 300                 


Gly Ser Phe Ile Asp Ser Arg Val Trp Phe Ser Val Tyr Gly Gly Leu 
305                 310                 315                 320 


Lys Pro Asn Thr Pro Ser Asp Thr Val Gln Glu Gly Lys Tyr Val Ile 
                325                 330                 335     


Tyr Lys Arg Tyr Asn Asp Thr Cys Pro Asp Glu Gln Asp Tyr Gln Ile 
            340                 345                 350         


Arg Met Ala Lys Ser Ser Tyr Lys Pro Gly Arg Phe Gly Gly Lys Arg 
        355                 360                 365             


Ile Gln Gln Ala Ile Leu Ser Ile Lys Val Ser Thr Ser Leu Gly Glu 
    370                 375                 380                 


Asp Pro Val Leu Thr Val Pro Pro Asn Thr Val Thr Leu Met Gly Ala 
385                 390                 395                 400 


Glu Gly Arg Ile Leu Thr Val Gly Thr Ser His Phe Leu Tyr Gln Arg 
                405                 410                 415     


Gly Ser Ser Tyr Phe Ser Pro Ala Leu Leu Tyr Pro Met Thr Val Ser 
            420                 425                 430         


Asp Lys Thr Ala Thr Leu His Ser Pro Tyr Thr Phe Asn Ala Phe Thr 
        435                 440                 445             


Arg Pro Gly Ser Ile Pro Cys Gln Ala Ser Ala Arg Cys Pro Asn Ser 
    450                 455                 460                 


Cys Val Thr Gly Val Tyr Thr Asp Pro Tyr Pro Leu Ile Phe Tyr Arg 
465                 470                 475                 480 


Asn His Thr Leu Arg Gly Val Phe Gly Thr Met Leu Asp Gly Glu Gln 
                485                 490                 495     


Ala Arg Leu Asn Pro Ala Ser Ala Val Phe Asp Ser Thr Ser Arg Ser 
            500                 505                 510         


Arg Ile Thr Arg Val Ser Ser Ser Ser Ile Lys Ala Ala Tyr Thr Thr 
        515                 520                 525             


Ser Thr Cys Phe Lys Val Val Lys Thr Asn Lys Thr Tyr Cys Leu Ser 
    530                 535                 540                 


Ile Ala Glu Ile Ser Asn Thr Leu Phe Gly Glu Phe Arg Ile Val Pro 
545                 550                 555                 560 


Leu Leu Val Glu Ile Leu Lys Asp Asp Gly Val Arg Glu Ala Arg Ser 
                565                 570                 575     


Gly 
    


<210>  7
<211>  1782
<212>  DNA
<213>  Newcastle disease virus

<400>  7
acgggtagaa gactctggat cccggttggc gccctccagg tgcaggatgg gctccagacc       60

ttttaccaag aacccagcac ctatgatgct gactatccgg gtcgcgctgg tattgagttg      120

catctgtccg gcaaactcca ttgatggcag gccttttgca gctgcaggaa ttgtggttac      180

aggagacaaa gcagtcaaca tatacacctc atcccagaca ggatcaatca tagttaagct      240

cctcccgaat ctgcccaagg ataaggaggc atgtgcgaaa gcccccttgg atgcatacaa      300

caggacattg accactttgc tcacccccct tggtgactct atccgtagga tacaagagtc      360

tgtgactaca tctggagggg ggagacaggg gcgccttata ggcgccatta ttggcggtgt      420

ggctcttggg gttgcaactg ccgcacaaat aacagcggcc gcagctctga tacaagccaa      480

acaaaatgct gccaacatcc tccgacttaa agagagcatt gccgcaacca atgaggctgt      540

gcatgaggtc actgacggat tatcccaact agcagtggca gttgggaaga tgcagcagtt      600

tgttaatgac caatttaata aaacagctca ggaattagac tgcataaaaa ttgcacagca      660

agttggtgta gagctcaacc tgtacctaac cgaattgact acagtattcg gaccacaaat      720

cacttcacct gccttaaaca agctgactat tcaggcactt tacaatctag ctggtgggaa      780

tatggattac ttattgacta agttaggtat agggaacaat caactcagct cattaatcgg      840

tagcggctta atcaccggta accctattct atacgactca cagactcaac tcttgggtat      900

acaggtaact ctaccttcag tcgggaacct aaataatatg cgtgccacct acttggaaac      960

cttatccgta agcacaacca ggggatttgc ctcggcactt gtcccaaaag tggtgacaca     1020

ggtcggttct gtgatagaag aacttgacac ctcatactgt atagaaactg acttagattt     1080

atattgtaca agaatagtaa cgttccctat gtcccctggt atttactcct gcttgagcgg     1140

caatacatcg gcctgtatgt actcaaagac cgaaggcgca cttactacac catatatgac     1200

tatcaaaggc tcagtcatcg ctaactgcaa gatgacaaca tgtagatgtg taaacccccc     1260

gggtatcata tcgcaaaact atggagaagc cgtgtctcta atagataaac aatcatgcaa     1320

tgttttatcc ttaggcggga taactttaag gctcagtggg gaattcgatg taacttatca     1380

gaagaatatc tcaatacaag attctcaagt aataataaca ggcaatcttg atatctcaac     1440

tgagcttggg aatgtcaaca actcgatcag taatgctttg aataagttag aggaaagcaa     1500

cagaaaacta gacaaagtca atgtcaaact gaccagcaca tctgctctca ttacctatat     1560

cgttttgact atcatatctc ttgtttttgg tatacttagc ctgattctag catgctacct     1620

aatgtacaag caaaaggcgc aacaaaagac cttattatgg cttgggaata ataccctaga     1680

tcagatgaga gccactacaa aaatgtgaac acagatgagg aacgaaggtt tccctaatag     1740

taatttgtgt gaaagttctg gtagtctgtc agttcggaga gt                        1782


<210>  8
<211>  553
<212>  PRT
<213>  Newcastle disease virus

<400>  8

Met Gly Ser Arg Pro Phe Thr Lys Asn Pro Ala Pro Met Met Leu Thr 
1               5                   10                  15      


Ile Arg Val Ala Leu Val Leu Ser Cys Ile Cys Pro Ala Asn Ser Ile 
            20                  25                  30          


Asp Gly Arg Pro Phe Ala Ala Ala Gly Ile Val Val Thr Gly Asp Lys 
        35                  40                  45              


Ala Val Asn Ile Tyr Thr Ser Ser Gln Thr Gly Ser Ile Ile Val Lys 
    50                  55                  60                  


Leu Leu Pro Asn Leu Pro Lys Asp Lys Glu Ala Cys Ala Lys Ala Pro 
65                  70                  75                  80  


Leu Asp Ala Tyr Asn Arg Thr Leu Thr Thr Leu Leu Thr Pro Leu Gly 
                85                  90                  95      


Asp Ser Ile Arg Arg Ile Gln Glu Ser Val Thr Thr Ser Gly Gly Gly 
            100                 105                 110         


Arg Gln Gly Arg Leu Ile Gly Ala Ile Ile Gly Gly Val Ala Leu Gly 
        115                 120                 125             


Val Ala Thr Ala Ala Gln Ile Thr Ala Ala Ala Ala Leu Ile Gln Ala 
    130                 135                 140                 


Lys Gln Asn Ala Ala Asn Ile Leu Arg Leu Lys Glu Ser Ile Ala Ala 
145                 150                 155                 160 


Thr Asn Glu Ala Val His Glu Val Thr Asp Gly Leu Ser Gln Leu Ala 
                165                 170                 175     


Val Ala Val Gly Lys Met Gln Gln Phe Val Asn Asp Gln Phe Asn Lys 
            180                 185                 190         


Thr Ala Gln Glu Leu Asp Cys Ile Lys Ile Ala Gln Gln Val Gly Val 
        195                 200                 205             


Glu Leu Asn Leu Tyr Leu Thr Glu Leu Thr Thr Val Phe Gly Pro Gln 
    210                 215                 220                 


Ile Thr Ser Pro Ala Leu Asn Lys Leu Thr Ile Gln Ala Leu Tyr Asn 
225                 230                 235                 240 


Leu Ala Gly Gly Asn Met Asp Tyr Leu Leu Thr Lys Leu Gly Ile Gly 
                245                 250                 255     


Asn Asn Gln Leu Ser Ser Leu Ile Gly Ser Gly Leu Ile Thr Gly Asn 
            260                 265                 270         


Pro Ile Leu Tyr Asp Ser Gln Thr Gln Leu Leu Gly Ile Gln Val Thr 
        275                 280                 285             


Leu Pro Ser Val Gly Asn Leu Asn Asn Met Arg Ala Thr Tyr Leu Glu 
    290                 295                 300                 


Thr Leu Ser Val Ser Thr Thr Arg Gly Phe Ala Ser Ala Leu Val Pro 
305                 310                 315                 320 


Lys Val Val Thr Gln Val Gly Ser Val Ile Glu Glu Leu Asp Thr Ser 
                325                 330                 335     


Tyr Cys Ile Glu Thr Asp Leu Asp Leu Tyr Cys Thr Arg Ile Val Thr 
            340                 345                 350         


Phe Pro Met Ser Pro Gly Ile Tyr Ser Cys Leu Ser Gly Asn Thr Ser 
        355                 360                 365             


Ala Cys Met Tyr Ser Lys Thr Glu Gly Ala Leu Thr Thr Pro Tyr Met 
    370                 375                 380                 


Thr Ile Lys Gly Ser Val Ile Ala Asn Cys Lys Met Thr Thr Cys Arg 
385                 390                 395                 400 


Cys Val Asn Pro Pro Gly Ile Ile Ser Gln Asn Tyr Gly Glu Ala Val 
                405                 410                 415     


Ser Leu Ile Asp Lys Gln Ser Cys Asn Val Leu Ser Leu Gly Gly Ile 
            420                 425                 430         


Thr Leu Arg Leu Ser Gly Glu Phe Asp Val Thr Tyr Gln Lys Asn Ile 
        435                 440                 445             


Ser Ile Gln Asp Ser Gln Val Ile Ile Thr Gly Asn Leu Asp Ile Ser 
    450                 455                 460                 


Thr Glu Leu Gly Asn Val Asn Asn Ser Ile Ser Asn Ala Leu Asn Lys 
465                 470                 475                 480 


Leu Glu Glu Ser Asn Arg Lys Leu Asp Lys Val Asn Val Lys Leu Thr 
                485                 490                 495     


Ser Thr Ser Ala Leu Ile Thr Tyr Ile Val Leu Thr Ile Ile Ser Leu 
            500                 505                 510         


Val Phe Gly Ile Leu Ser Leu Ile Leu Ala Cys Tyr Leu Met Tyr Lys 
        515                 520                 525             


Gln Lys Ala Gln Gln Lys Thr Leu Leu Trp Leu Gly Asn Asn Thr Leu 
    530                 535                 540                 


Asp Gln Met Arg Ala Thr Thr Lys Met 
545                 550             


<210>  9
<211>  1662
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NDV F3aa-modified fusion protein

<400>  9
atgggctcca gaccttctac caagaaccca gcacctatga tgctgactat ccgggtcgcg       60

ctggtactga gttgcatctg cccggcaaac tccattgatg gcaggcctct tgcagctgca      120

ggaattgtgg ttacaggaga caaagcagtc aacatataca cctcatccca gacaggatca      180

atcatagtta agctcctccc gaatctgccc aaggataagg aggcatgtgc gaaagccccc      240

ttggatgcat acaacaggac attgaccact ttgctcaccc cccttggtga ctctatccgt      300

aggatacaag agtctgtgac tacatctgga gggcggagac agaggcgctt tataggcgcc      360

attattggcg gtgtggctct tggggttgca actgccgcac aaataacagc ggccgcagct      420

ctgatacaag ccaaacaaaa tgctgccaac atcctccgac ttaaagagag cattgccgca      480

accaatgagg ctgtgcatga ggtcactgac ggattatcgc aactagcagt ggcagttggg      540

aagatgcagc agtttgttaa tgaccaattt aataaaacag ctcaggaatt agactgcatc      600

aaaattgcac agcaagttgg tgtagagctc aacctgtacc taaccgaatt gactacagta      660

ttcggaccac aaatcacttc acctgcctta aacaagctga ctattcaggc actttacaat      720

ctagctggtg ggaatatgga ttacttattg actaagttag gtatagggaa caatcaactc      780

agctcattaa tcggtagcgg cttaatcacc ggtaacccta ttctatacga ctcacagact      840

caactcttgg gtatacaggt aactctacct tcagtcggga acctaaataa tatgcgtgcc      900

acctacttgg aaaccttatc cgtaagcaca accaggggat ttgcctcggc acttgtccca      960

aaagtggtga cacaggtcgg ttctgtgata gaagaacttg acacctcata ctgtatagaa     1020

actgacttag atttatattg tacaagaata gtaacgttcc ctatgtcccc tggtatttac     1080

tcctgcttga gcggcaatac atcggcctgt atgtactcaa agaccgaagg cgcacttact     1140

acaccatata tgactatcaa aggctcagtc atcgctaact gcaagatgac aacatgtaga     1200

tgtgtaaacc ccccgggtat catatcgcaa aactatggag aagccgtgtc tctaatagat     1260

aaacaatcat gcaatgtttt atccttaggc gggataactt taaggctcag tggggaattc     1320

gatgtaactt atcagaagaa tatctcaata caagattctc aagtaataat aacaggcaat     1380

cttgatatct caactgagct tgggaatgtc aacaactcga tcagtaatgc tttgaataag     1440

ttagaggaaa gcaacagaaa actagacaaa gtcaatgtca aactgaccag cacatctgct     1500

ctcattacct atatcgtttt gactatcata tctcttgttt ttggtatact tagcctgatt     1560

ctagcatgct acctaatgta caagcaaaag gcgcaacaaa agaccttatt atggcttggg     1620

aataataccc tagatcagat gagagccact acaaaaatgt ga                        1662


<210>  10
<211>  553
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NDV F3aa-modified fusion protein

<400>  10

Met Gly Ser Arg Pro Phe Thr Lys Asn Pro Ala Pro Met Met Leu Thr 
1               5                   10                  15      


Ile Arg Val Ala Leu Val Leu Ser Cys Ile Cys Pro Ala Asn Ser Ile 
            20                  25                  30          


Asp Gly Arg Pro Phe Ala Ala Ala Gly Ile Val Val Thr Gly Asp Lys 
        35                  40                  45              


Ala Val Asn Ile Tyr Thr Ser Ser Gln Thr Gly Ser Ile Ile Val Lys 
    50                  55                  60                  


Leu Leu Pro Asn Leu Pro Lys Asp Lys Glu Ala Cys Ala Lys Ala Pro 
65                  70                  75                  80  


Leu Asp Ala Tyr Asn Arg Thr Leu Thr Thr Leu Leu Thr Pro Leu Gly 
                85                  90                  95      


Asp Ser Ile Arg Arg Ile Gln Glu Ser Val Thr Thr Ser Gly Gly Arg 
            100                 105                 110         


Arg Gln Arg Arg Phe Ile Gly Ala Ile Ile Gly Gly Val Ala Leu Gly 
        115                 120                 125             


Val Ala Thr Ala Ala Gln Ile Thr Ala Ala Ala Ala Leu Ile Gln Ala 
    130                 135                 140                 


Lys Gln Asn Ala Ala Asn Ile Leu Arg Leu Lys Glu Ser Ile Ala Ala 
145                 150                 155                 160 


Thr Asn Glu Ala Val His Glu Val Thr Asp Gly Leu Ser Gln Leu Ala 
                165                 170                 175     


Val Ala Val Gly Lys Met Gln Gln Phe Val Asn Asp Gln Phe Asn Lys 
            180                 185                 190         


Thr Ala Gln Glu Leu Asp Cys Ile Lys Ile Ala Gln Gln Val Gly Val 
        195                 200                 205             


Glu Leu Asn Leu Tyr Leu Thr Glu Leu Thr Thr Val Phe Gly Pro Gln 
    210                 215                 220                 


Ile Thr Ser Pro Ala Leu Asn Lys Leu Thr Ile Gln Ala Leu Tyr Asn 
225                 230                 235                 240 


Leu Ala Gly Gly Asn Met Asp Tyr Leu Leu Thr Lys Leu Gly Ile Gly 
                245                 250                 255     


Asn Asn Gln Leu Ser Ser Leu Ile Gly Ser Gly Leu Ile Thr Gly Asn 
            260                 265                 270         


Pro Ile Leu Tyr Asp Ser Gln Thr Gln Leu Leu Gly Ile Gln Val Thr 
        275                 280                 285             


Leu Pro Ser Val Gly Asn Leu Asn Asn Met Arg Ala Thr Tyr Leu Glu 
    290                 295                 300                 


Thr Leu Ser Val Ser Thr Thr Arg Gly Phe Ala Ser Ala Leu Val Pro 
305                 310                 315                 320 


Lys Val Val Thr Gln Val Gly Ser Val Ile Glu Glu Leu Asp Thr Ser 
                325                 330                 335     


Tyr Cys Ile Glu Thr Asp Leu Asp Leu Tyr Cys Thr Arg Ile Val Thr 
            340                 345                 350         


Phe Pro Met Ser Pro Gly Ile Tyr Ser Cys Leu Ser Gly Asn Thr Ser 
        355                 360                 365             


Ala Cys Met Tyr Ser Lys Thr Glu Gly Ala Leu Thr Thr Pro Tyr Met 
    370                 375                 380                 


Thr Ile Lys Gly Ser Val Ile Ala Asn Cys Lys Met Thr Thr Cys Arg 
385                 390                 395                 400 


Cys Val Asn Pro Pro Gly Ile Ile Ser Gln Asn Tyr Gly Glu Ala Val 
                405                 410                 415     


Ser Leu Ile Asp Lys Gln Ser Cys Asn Val Leu Ser Leu Gly Gly Ile 
            420                 425                 430         


Thr Leu Arg Leu Ser Gly Glu Phe Asp Val Thr Tyr Gln Lys Asn Ile 
        435                 440                 445             


Ser Ile Gln Asp Ser Gln Val Ile Ile Thr Gly Asn Leu Asp Ile Ser 
    450                 455                 460                 


Thr Glu Leu Gly Asn Val Asn Asn Ser Ile Ser Asn Ala Leu Asn Lys 
465                 470                 475                 480 


Leu Glu Glu Ser Asn Arg Lys Leu Asp Lys Val Asn Val Lys Leu Thr 
                485                 490                 495     


Ser Thr Ser Ala Leu Ile Thr Tyr Ile Val Leu Thr Ile Ile Ser Leu 
            500                 505                 510         


Val Phe Gly Ile Leu Ser Leu Ile Leu Ala Cys Tyr Leu Met Tyr Lys 
        515                 520                 525             


Gln Lys Ala Gln Gln Lys Thr Leu Leu Trp Leu Gly Asn Asn Thr Leu 
    530                 535                 540                 


Asp Gln Met Arg Ala Thr Thr Lys Met 
545                 550             


<210>  11
<211>  1662
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NDV F3aa-modified fusion protein with L289A

<400>  11
atgggctcca gaccttctac caagaaccca gcacctatga tgctgactat ccgggtcgcg       60

ctggtactga gttgcatctg cccggcaaac tccattgatg gcaggcctct tgcagctgca      120

ggaattgtgg ttacaggaga caaagcagtc aacatataca cctcatccca gacaggatca      180

atcatagtta agctcctccc gaatctgccc aaggataagg aggcatgtgc gaaagccccc      240

ttggatgcat acaacaggac attgaccact ttgctcaccc cccttggtga ctctatccgt      300

aggatacaag agtctgtgac tacatctgga gggcggagac agaggcgctt tataggcgcc      360

attattggcg gtgtggctct tggggttgca actgccgcac aaataacagc ggccgcagct      420

ctgatacaag ccaaacaaaa tgctgccaac atcctccgac ttaaagagag cattgccgca      480

accaatgagg ctgtgcatga ggtcactgac ggattatcgc aactagcagt ggcagttggg      540

aagatgcagc agtttgttaa tgaccaattt aataaaacag ctcaggaatt agactgcatc      600

aaaattgcac agcaagttgg tgtagagctc aacctgtacc taaccgaatt gactacagta      660

ttcggaccac aaatcacttc acctgcctta aacaagctga ctattcaggc actttacaat      720

ctagctggtg ggaatatgga ttacttattg actaagttag gtatagggaa caatcaactc      780

agctcattaa tcggtagcgg cttaatcacc ggtaacccta ttctatacga ctcacagact      840

caactcttgg gtatacaggt aactgcacct tcagtcggga acctaaataa tatgcgtgcc      900

acctacttgg aaaccttatc cgtaagcaca accaggggat ttgcctcggc acttgtccca      960

aaagtggtga cacaggtcgg ttctgtgata gaagaacttg acacctcata ctgtatagaa     1020

actgacttag atttatattg tacaagaata gtaacgttcc ctatgtcccc tggtatttac     1080

tcctgcttga gcggcaatac atcggcctgt atgtactcaa agaccgaagg cgcacttact     1140

acaccatata tgactatcaa aggctcagtc atcgctaact gcaagatgac aacatgtaga     1200

tgtgtaaacc ccccgggtat catatcgcaa aactatggag aagccgtgtc tctaatagat     1260

aaacaatcat gcaatgtttt atccttaggc gggataactt taaggctcag tggggaattc     1320

gatgtaactt atcagaagaa tatctcaata caagattctc aagtaataat aacaggcaat     1380

cttgatatct caactgagct tgggaatgtc aacaactcga tcagtaatgc tttgaataag     1440

ttagaggaaa gcaacagaaa actagacaaa gtcaatgtca aactgaccag cacatctgct     1500

ctcattacct atatcgtttt gactatcata tctcttgttt ttggtatact tagcctgatt     1560

ctagcatgct acctaatgta caagcaaaag gcgcaacaaa agaccttatt atggcttggg     1620

aataataccc tagatcagat gagagccact acaaaaatgt ga                        1662


<210>  12
<211>  553
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NDV F3aa-modified fusion protein with L289A

<400>  12

Met Gly Ser Arg Pro Phe Thr Lys Asn Pro Ala Pro Met Met Leu Thr 
1               5                   10                  15      


Ile Arg Val Ala Leu Val Leu Ser Cys Ile Cys Pro Ala Asn Ser Ile 
            20                  25                  30          


Asp Gly Arg Pro Phe Ala Ala Ala Gly Ile Val Val Thr Gly Asp Lys 
        35                  40                  45              


Ala Val Asn Ile Tyr Thr Ser Ser Gln Thr Gly Ser Ile Ile Val Lys 
    50                  55                  60                  


Leu Leu Pro Asn Leu Pro Lys Asp Lys Glu Ala Cys Ala Lys Ala Pro 
65                  70                  75                  80  


Leu Asp Ala Tyr Asn Arg Thr Leu Thr Thr Leu Leu Thr Pro Leu Gly 
                85                  90                  95      


Asp Ser Ile Arg Arg Ile Gln Glu Ser Val Thr Thr Ser Gly Gly Arg 
            100                 105                 110         


Arg Gln Arg Arg Phe Ile Gly Ala Ile Ile Gly Gly Val Ala Leu Gly 
        115                 120                 125             


Val Ala Thr Ala Ala Gln Ile Thr Ala Ala Ala Ala Leu Ile Gln Ala 
    130                 135                 140                 


Lys Gln Asn Ala Ala Asn Ile Leu Arg Leu Lys Glu Ser Ile Ala Ala 
145                 150                 155                 160 


Thr Asn Glu Ala Val His Glu Val Thr Asp Gly Leu Ser Gln Leu Ala 
                165                 170                 175     


Val Ala Val Gly Lys Met Gln Gln Phe Val Asn Asp Gln Phe Asn Lys 
            180                 185                 190         


Thr Ala Gln Glu Leu Asp Cys Ile Lys Ile Ala Gln Gln Val Gly Val 
        195                 200                 205             


Glu Leu Asn Leu Tyr Leu Thr Glu Leu Thr Thr Val Phe Gly Pro Gln 
    210                 215                 220                 


Ile Thr Ser Pro Ala Leu Asn Lys Leu Thr Ile Gln Ala Leu Tyr Asn 
225                 230                 235                 240 


Leu Ala Gly Gly Asn Met Asp Tyr Leu Leu Thr Lys Leu Gly Ile Gly 
                245                 250                 255     


Asn Asn Gln Leu Ser Ser Leu Ile Gly Ser Gly Leu Ile Thr Gly Asn 
            260                 265                 270         


Pro Ile Leu Tyr Asp Ser Gln Thr Gln Leu Leu Gly Ile Gln Val Thr 
        275                 280                 285             


Ala Pro Ser Val Gly Asn Leu Asn Asn Met Arg Ala Thr Tyr Leu Glu 
    290                 295                 300                 


Thr Leu Ser Val Ser Thr Thr Arg Gly Phe Ala Ser Ala Leu Val Pro 
305                 310                 315                 320 


Lys Val Val Thr Gln Val Gly Ser Val Ile Glu Glu Leu Asp Thr Ser 
                325                 330                 335     


Tyr Cys Ile Glu Thr Asp Leu Asp Leu Tyr Cys Thr Arg Ile Val Thr 
            340                 345                 350         


Phe Pro Met Ser Pro Gly Ile Tyr Ser Cys Leu Ser Gly Asn Thr Ser 
        355                 360                 365             


Ala Cys Met Tyr Ser Lys Thr Glu Gly Ala Leu Thr Thr Pro Tyr Met 
    370                 375                 380                 


Thr Ile Lys Gly Ser Val Ile Ala Asn Cys Lys Met Thr Thr Cys Arg 
385                 390                 395                 400 


Cys Val Asn Pro Pro Gly Ile Ile Ser Gln Asn Tyr Gly Glu Ala Val 
                405                 410                 415     


Ser Leu Ile Asp Lys Gln Ser Cys Asn Val Leu Ser Leu Gly Gly Ile 
            420                 425                 430         


Thr Leu Arg Leu Ser Gly Glu Phe Asp Val Thr Tyr Gln Lys Asn Ile 
        435                 440                 445             


Ser Ile Gln Asp Ser Gln Val Ile Ile Thr Gly Asn Leu Asp Ile Ser 
    450                 455                 460                 


Thr Glu Leu Gly Asn Val Asn Asn Ser Ile Ser Asn Ala Leu Asn Lys 
465                 470                 475                 480 


Leu Glu Glu Ser Asn Arg Lys Leu Asp Lys Val Asn Val Lys Leu Thr 
                485                 490                 495     


Ser Thr Ser Ala Leu Ile Thr Tyr Ile Val Leu Thr Ile Ile Ser Leu 
            500                 505                 510         


Val Phe Gly Ile Leu Ser Leu Ile Leu Ala Cys Tyr Leu Met Tyr Lys 
        515                 520                 525             


Gln Lys Ala Gln Gln Lys Thr Leu Leu Trp Leu Gly Asn Asn Thr Leu 
    530                 535                 540                 


Asp Gln Met Arg Ala Thr Thr Lys Met 
545                 550             


<210>  13
<211>  13006
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Virus/vector construct

<400>  13
acgaagacaa acaaaccatt attatcatta aaaggctcag gagaaacttt aacagtaatc       60

aaaatgtctg ttacagtcaa gagaatcatt gacaacacag tcgtagttcc aaaacttcct      120

gcaaatgagg atccagtgga atacccggca gattacttca gaaaatcaaa ggagattcct      180

ctttacatca atactacaaa aagtttgtca gatctaagag gatatgtcta ccaaggcctc      240

aaatccggaa atgtatcaat catacatgtc aacagctact tgtatggagc attaaaggac      300

atccggggta agttggataa agattggtca agtttcggaa taaacatcgg gaaagcaggg      360

gatacaatcg gaatatttga ccttgtatcc ttgaaagccc tggacggcgt acttccagat      420

ggagtatcgg atgcttccag aaccagcgca gatgacaaat ggttgccttt gtatctactt      480

ggcttataca gagtgggcag aacacaaatg cctgaataca gaaaaaagct catggatggg      540

ctgacaaatc aatgcaaaat gatcaatgaa cagtttgaac ctcttgtgcc agaaggtcgt      600

gacatttttg atgtgtgggg aaatgacagt aattacacaa aaattgtcgc tgcagtggac      660

atgttcttcc acatgttcaa aaaacatgaa tgtgcctcgt tcagatacgg aactattgtt      720

tccagattca aagattgtgc tgcattggca acatttggac acctctgcaa aataaccgga      780

atgtctacag aagatgtaac gacctggatc ttgaaccgag aagttgcaga tgaaatggtc      840

caaatgatgc ttccaggcca agaaattgac aaggccgatt catacatgcc ttatttgatc      900

gactttggat tgtcttctaa gtctccatat tcttccgtca aaaaccctgc cttccacttc      960

tgggggcaat tgacagctct tctgctcaga tccaccagag caaggaatgc ccgacagcct     1020

gatgacattg agtatacatc tcttactaca gcaggtttgt tgtacgctta tgcagtagga     1080

tcctctgccg acttggcaca acagttttgt gttggagata acaaatacac tccagatgat     1140

agtaccggag gattgacgac taatgcaccg ccacaaggca gagatgtggt cgaatggctc     1200

ggatggtttg aagatcaaaa cagaaaaccg actcctgata tgatgcagta tgcgaaaaga     1260

gcagtcatgt cactgcaagg cctaagagag aagacaattg gcaagtatgc taagtcagaa     1320

tttgacaaat gaccctataa ttctcagatc acctattata tattatgcta catatgaaaa     1380

aaactaacag atatcatgga taatctcaca aaagttcgtg agtatctcaa gtcctattct     1440

cgtctggatc aggcggtagg agagatagat gagatcgaag cacaacgagc tgaaaagtcc     1500

aattatgagt tgttccaaga ggatggagtg gaagagcata ctaagccctc ttattttcag     1560

gcagcagatg attctgacac agaatctgaa ccagaaattg aagacaatca aggcttgtat     1620

gcaccagatc cagaagctga gcaagttgaa ggctttatac aggggccttt agatgactat     1680

gcagatgagg aagtggatgt tgtatttact tcggactgga aacagcctga gcttgaatct     1740

gacgagcatg gaaagacctt acggttgaca tcgccagagg gtttaagtgg agagcagaaa     1800

tcccagtggc tttcgacgat taaagcagtc gtgcaaagtg ccaaatactg gaatctggca     1860

gagtgcacat ttgaagcatc gggagaaggg gtcattatga aggagcgcca gataactccg     1920

gatgtatata aggtcactcc agtgatgaac acacatccgt cccaatcaga agcagtatca     1980

gatgtttggt ctctctcaaa gacatccatg actttccaac ccaagaaagc aagtcttcag     2040

cctctcacca tatccttgga tgaattgttc tcatctagag gagagttcat ctctgtcgga     2100

ggtgacggac gaatgtctca taaagaggcc atcctgctcg gcctgagata caaaaagttg     2160

tacaatcagg cgagagtcaa atattctctg tagactatga aaaaaagtaa cagatatcac     2220

gatctaagtg ttatcccaat ccattcatca tgagttcctt aaagaagatt ctcggtctga     2280

aggggaaagg taagaaatct aagaaattag ggatcgcacc acccccttat gaagaggaca     2340

ctagcatgga gtatgctccg agcgctccaa ttgacaaatc ctattttgga gttgacgaga     2400

tggacaccta tgatccgaat caattaagat atgagaaatt cttctttaca gtgaaaatga     2460

cggttagatc taatcgtccg ttcagaacat actcagatgt ggcagccgct gtatcccatt     2520

gggatcacat gtacatcgga atggcaggga aacgtccctt ctacaaaatc ttggcttttt     2580

tgggttcttc taatctaaag gccactccag cggtattggc agatcaaggt caaccagagt     2640

atcacgctca ctgcgaaggc agggcttatt tgccacatag gatggggaag acccctccca     2700

tgctcaatgt accagagcac ttcagaagac cattcaatat aggtctttac aagggaacga     2760

ttgagctcac aatgaccatc tacgatgatg agtcactgga agcagctcct atgatctggg     2820

atcatttcaa ttcttccaaa ttttctgatt tcagagagaa ggccttaatg tttggcctga     2880

ttgtcgagaa aaaggcatct ggagcgtggg tcctggactc tatcggccac ttcaaatgag     2940

ctagtctaac ttctagcttc tgaacaatcc ccggtttact cagtctcccc taattccagc     3000

ctctcgaaca actaatatcc tgtcttttct atccctatga aaaaaactaa cagagatcga     3060

tctgtttacg cgtcgagatg ggctccagac cttctaccaa gaacccagca cctatgatgc     3120

tgactatccg ggtcgcgctg gtactgagtt gcatctgccc ggcaaactcc attgatggca     3180

ggcctcttgc agctgcagga attgtggtta caggagacaa agcagtcaac atatacacct     3240

catcccagac aggatcaatc atagttaagc tcctcccgaa tctgcccaag gataaggagg     3300

catgtgcgaa agcccccttg gatgcataca acaggacatt gaccactttg ctcacccccc     3360

ttggtgactc tatccgtagg atacaagagt ctgtgactac atctggaggg cggagacaga     3420

ggcgctttat aggcgccatt attggcggtg tggctcttgg ggttgcaact gccgcacaaa     3480

taacagcggc cgcagctctg atacaagcca aacaaaatgc tgccaacatc ctccgactta     3540

aagagagcat tgccgcaacc aatgaggctg tgcatgaggt cactgacgga ttatcgcaac     3600

tagcagtggc agttgggaag atgcagcagt ttgttaatga ccaatttaat aaaacagctc     3660

aggaattaga ctgcatcaaa attgcacagc aagttggtgt agagctcaac ctgtacctaa     3720

ccgaattgac tacagtattc ggaccacaaa tcacttcacc tgccttaaac aagctgacta     3780

ttcaggcact ttacaatcta gctggtggga atatggatta cttattgact aagttaggta     3840

tagggaacaa tcaactcagc tcattaatcg gtagcggctt aatcaccggt aaccctattc     3900

tatacgactc acagactcaa ctcttgggta tacaggtaac tgcaccttca gtcgggaacc     3960

taaataatat gcgtgccacc tacttggaaa ccttatccgt aagcacaacc aggggatttg     4020

cctcggcact tgtcccaaaa gtggtgacac aggtcggttc tgtgatagaa gaacttgaca     4080

cctcatactg tatagaaact gacttagatt tatattgtac aagaatagta acgttcccta     4140

tgtcccctgg tatttactcc tgcttgagcg gcaatacatc ggcctgtatg tactcaaaga     4200

ccgaaggcgc acttactaca ccatatatga ctatcaaagg ctcagtcatc gctaactgca     4260

agatgacaac atgtagatgt gtaaaccccc cgggtatcat atcgcaaaac tatggagaag     4320

ccgtgtctct aatagataaa caatcatgca atgttttatc cttaggcggg ataactttaa     4380

ggctcagtgg ggaattcgat gtaacttatc agaagaatat ctcaatacaa gattctcaag     4440

taataataac aggcaatctt gatatctcaa ctgagcttgg gaatgtcaac aactcgatca     4500

gtaatgcttt gaataagtta gaggaaagca acagaaaact agacaaagtc aatgtcaaac     4560

tgaccagcac atctgctctc attacctata tcgttttgac tatcatatct cttgtttttg     4620

gtatacttag cctgattcta gcatgctacc taatgtacaa gcaaaaggcg caacaaaaga     4680

ccttattatg gcttgggaat aataccctag atcagatgag agccactaca aaaatgtgag     4740

ctagcttaat taatatgaaa aaaactaaca gatatcatgg accgcgccgt tagccaagtt     4800

gcgttagaga atgatgaaag agaggcaaaa aatacatggc gcttgatatt ccggattgca     4860

atcttattct taacagtagt gaccttggct atatctgtag cctccctttt atatagcatg     4920

ggggctagca cacctagcga tcttgtaggc ataccgacta ggatttccag ggcagaagaa     4980

aagattacat ctacacttgg ttccaatcaa gatgtagtag ataggatata taagcaagtg     5040

gcccttgagt ctccattggc attgttaaat actgagacca caattatgaa cgcaataaca     5100

tctctctctt atcagattaa tggagctgca aacaacagcg ggtggggggc acctattcat     5160

gacccagatt atataggggg gataggcaaa gaactcattg tagatgatgc tagtgatgtc     5220

acatcattct atccctctgc atttcaagaa catctgaatt ttatcccggc gcctactaca     5280

ggatcaggtt gcactcgaat accctcattt gacatgagtg ctacccatta ctgctacacc     5340

cataatgtaa tattgtctgg atgcagagat cactcacact cacatcagta tttagcactt     5400

ggtgtgctcc ggacatctgc aacagggagg gtattctttt ctactctgcg ttccatcaac     5460

ctggacgaca cccaaaatcg gaagtcttgc agtgtgagtg caactcccct gggttgtgat     5520

atgctgtgct cgaaagccac ggagacagag gaagaagatt ataactcagc tgtccctacg     5580

cggatggtac atgggaggtt agggttcgac ggccaatatc acgaaaagga cctagatgtc     5640

acaacattat tcggggactg ggtggccaac tacccaggag tagggggtgg atcttttatt     5700

gacagccgcg tatggttctc agtctacgga gggttaaaac ccaatacacc cagtgacact     5760

gtacaggaag ggaaatatgt gatatacaag cgatacaatg acacatgccc agatgagcaa     5820

gactaccaga ttcgaatggc caagtcttcg tataagcctg gacggtttgg tgggaaacgc     5880

atacagcagg ctatcttatc tatcaaagtg tcaacatcct taggcgaaga cccggtactg     5940

actgtaccgc ccaacacagt cacactcatg ggggccgaag gcagaattct cacagtaggg     6000

acatcccatt tcttgtatca gcgagggtca tcatacttct ctcccgcgtt attatatcct     6060

atgacagtca gcgacaaaac agccactctt catagtcctt atacattcaa tgccttcact     6120

cggccaggta gtatcccttg ccaggcttca gcaagatgcc ccaactcgtg tgttactgga     6180

gtctatacag atccatatcc cctaatcttc tatagaaacc acaccttgcg aggggtattc     6240

gggacaatgc ttgatggtga acaagcaaga cttaaccctg cgtctgcagt attcgatagc     6300

acatcccgca gtcgcataac tcgagtgagt tcaagcagca tcaaagcagc atacacaaca     6360

tcaacttgtt ttaaagtggt caagaccaat aagacctatt gtctcagcat tgctgaaata     6420

tctaatactc tcttcggaga attcagaatc gtcccgttac tagttgagat cctcaaagat     6480

gacggggtta gagaagccag gtctggctag gtttaaacgc tagcggcctc aattatattt     6540

gagtttttaa tttttatgaa aaaaactaac agcaatcatg gaagtccacg attttgagac     6600

cgacgagttc aatgatttca atgaagatga ctatgccaca agagaattcc tgaatcccga     6660

tgagcgcatg acgtacttga atcatgctga ttacaacctg aattctcctc taattagtga     6720

tgatattgac aatttaatca ggaaattcaa ttctcttcca attccctcga tgtgggatag     6780

taagaactgg gatggagttc ttgagatgtt aacgtcatgt caagccaatc ccatcccaac     6840

atctcagatg cataaatgga tgggaagttg gttaatgtct gataatcatg atgccagtca     6900

agggtatagt tttttacatg aagtggacaa agaggcagaa ataacatttg acgtggtgga     6960

gaccttcatc cgcggctggg gcaacaaacc aattgaatac atcaaaaagg aaagatggac     7020

tgactcattc aaaattctcg cttatttgtg tcaaaagttt ttggacttac acaagttgac     7080

attaatctta aatgctgtct ctgaggtgga attgctcaac ttggcgagga ctttcaaagg     7140

caaagtcaga agaagttctc atggaacgaa catatgcagg attagggttc ccagcttggg     7200

tcctactttt atttcagaag gatgggctta cttcaagaaa cttgatattc taatggaccg     7260

aaactttctg ttaatggtca aagatgtgat tatagggagg atgcaaacgg tgctatccat     7320

ggtatgtaga atagacaacc tgttctcaga gcaagacatc ttctcccttc taaatatcta     7380

cagaattgga gataaaattg tggagaggca gggaaatttt tcttatgact tgattaaaat     7440

ggtggaaccg atatgcaact tgaagctgat gaaattagca agagaatcaa ggcctttagt     7500

cccacaattc cctcattttg aaaatcatat caagacttct gttgatgaag gggcaaaaat     7560

tgaccgaggt ataagattcc tccatgatca gataatgagt gtgaaaacag tggatctcac     7620

actggtgatt tatggatcgt tcagacattg gggtcatcct tttatagatt attacactgg     7680

actagaaaaa ttacattccc aagtaaccat gaagaaagat attgatgtgt catatgcaaa     7740

agcacttgca agtgatttag ctcggattgt tctatttcaa cagttcaatg atcataaaaa     7800

gtggttcgtg aatggagact tgctccctca tgatcatccc tttaaaagtc atgttaaaga     7860

aaatacatgg cccacagctg ctcaagttca agattttgga gataaatggc atgaacttcc     7920

gctgattaaa tgttttgaaa tacccgactt actagaccca tcgataatat actctgacaa     7980

aagtcattca atgaataggt cagaggtgtt gaaacatgtc cgaatgaatc cgaacactcc     8040

tatccctagt aaaaaggtgt tgcagactat gttggacaca aaggctacca attggaaaga     8100

atttcttaaa gagattgatg agaagggctt agatgatgat gatctaatta ttggtcttaa     8160

aggaaaggag agggaactga agttggcagg tagatttttc tccctaatgt cttggaaatt     8220

gcgagaatac tttgtaatta ccgaatattt gataaagact catttcgtcc ctatgtttaa     8280

aggcctgaca atggcggacg atctaactgc agtcattaaa aagatgttag attcctcatc     8340

cggccaagga ttgaagtcat atgaggcaat ttgcatagcc aatcacattg attacgaaaa     8400

atggaataac caccaaagga agttatcaaa cggcccagtg ttccgagtta tgggccagtt     8460

cttaggttat ccatccttaa tcgagagaac tcatgaattt tttgagaaaa gtcttatata     8520

ctacaatgga agaccagact tgatgcgtgt tcacaacaac acactgatca attcaacctc     8580

ccaacgagtt tgttggcaag gacaagaggg tggactggaa ggtctacggc aaaaaggatg     8640

gagtatcctc aatctactgg ttattcaaag agaggctaaa atcagaaaca ctgctgtcaa     8700

agtcttggca caaggtgata atcaagttat ttgcacacag tataaaacga agaaatcgag     8760

aaacgttgta gaattacagg gtgctctcaa tcaaatggtt tctaataatg agaaaattat     8820

gactgcaatc aaaataggga cagggaagtt aggacttttg ataaatgacg atgagactat     8880

gcaatctgca gattacttga attatggaaa aataccgatt ttccgtggag tgattagagg     8940

gttagagacc aagagatggt cacgagtgac ttgtgtcacc aatgaccaaa tacccacttg     9000

tgctaatata atgagctcag tttccacaaa tgctctcacc gtagctcatt ttgctgagaa     9060

cccaatcaat gccatgatac agtacaatta ttttgggaca tttgctagac tcttgttgat     9120

gatgcatgat cctgctcttc gtcaatcatt gtatgaagtt caagataaga taccgggctt     9180

gcacagttct actttcaaat acgccatgtt gtatttggac ccttccattg gaggagtgtc     9240

gggcatgtct ttgtccaggt ttttgattag agccttccca gatcccgtaa cagaaagtct     9300

ctcattctgg agattcatcc atgtacatgc tcgaagtgag catctgaagg agatgagtgc     9360

agtatttgga aaccccgaga tagccaagtt tcgaataact cacatagaca agctagtaga     9420

agatccaacc tctctgaaca tcgctatggg aatgagtcca gcgaacttgt taaagactga     9480

ggttaaaaaa tgcttaatcg aatcaagaca aaccatcagg aaccaggtga ttaaggatgc     9540

aaccatatat ttgtatcatg aagaggatcg gctcagaagt ttcttatggt caataaatcc     9600

tctgttccct agatttttaa gtgaattcaa atcaggcact tttttgggag tcgcagacgg     9660

gctcatcagt ctatttcaaa attctcgtac tattcggaac tcctttaaga aaaagtatca     9720

tagggaattg gatgatttga ttgtgaggag tgaggtatcc tctttgacac atttagggaa     9780

acttcatttg agaaggggat catgtaaaat gtggacatgt tcagctactc atgctgacac     9840

attaagatac aaatcctggg gccgtacagt tattgggaca actgtacccc atccattaga     9900

aatgttgggt ccacaacatc gaaaagagac tccttgtgca ccatgtaaca catcagggtt     9960

caattatgtt tctgtgcatt gtccagacgg gatccatgac gtctttagtt cacggggacc    10020

attgcctgct tatctagggt ctaaaacatc tgaatctaca tctattttgc agccttggga    10080

aagggaaagc aaagtcccac tgattaaaag agctacacgt cttagagatg ctatctcttg    10140

gtttgttgaa cccgactcta aactagcaat gactatactt tctaacatcc actctttaac    10200

aggcgaagaa tggaccaaaa ggcagcatgg gttcaaaaga acagggtctg cccttcatag    10260

gttttcgaca tctcggatga gccatggtgg gttcgcatct cagagcactg cagcattgac    10320

caggttgatg gcaactacag acaccatgag ggatctggga gatcagaatt tcgacttttt    10380

attccaagca acgttgctct atgctcaaat taccaccact gttgcaagag acggatggat    10440

caccagttgt acagatcatt atcatattgc ctgtaagtcc tgtttgagac ccatagaaga    10500

gatcaccctg gactcaagta tggactacac gcccccagat gtatcccatg tgctgaagac    10560

atggaggaat ggggaaggtt cgtggggaca agagataaaa cagatctatc ctttagaagg    10620

gaattggaag aatttagcac ctgctgagca atcctatcaa gtcggcagat gtataggttt    10680

tctatatgga gacttggcgt atagaaaatc tactcatgcc gaggacagtt ctctatttcc    10740

tctatctata caaggtcgta ttagaggtcg aggtttctta aaagggttgc tagacggatt    10800

aatgagagca agttgctgcc aagtaataca ccggagaagt ctggctcatt tgaagaggcc    10860

ggccaacgca gtgtacggag gtttgattta cttgattgat aaattgagtg tatcacctcc    10920

attcctttct cttactagat caggacctat tagagacgaa ttagaaacga ttccccacaa    10980

gatcccaacc tcctatccga caagcaaccg tgatatgggg gtgattgtca gaaattactt    11040

caaataccaa tgccgtctaa ttgaaaaggg aaaatacaga tcacattatt cacaattatg    11100

gttattctca gatgtcttat ccatagactt cattggacca ttctctattt ccaccaccct    11160

cttgcaaatc ctatacaagc catttttatc tgggaaagat aagaatgagt tgagagagct    11220

ggcaaatctt tcttcattgc taagatcagg agaggggtgg gaagacatac atgtgaaatt    11280

cttcaccaag gacatattat tgtgtccaga ggaaatcaga catgcttgca agttcgggat    11340

tgctaaggat aataataaag acatgagcta tcccccttgg ggaagggaat ccagagggac    11400

aattacaaca atccctgttt attatacgac caccccttac ccaaagatgc tagagatgcc    11460

tccaagaatc caaaatcccc tgctgtccgg aatcaggttg ggccaattac caactggcgc    11520

tcattataaa attcggagta tattacatgg aatgggaatc cattacaggg acttcttgag    11580

ttgtggagac ggctccggag ggatgactgc tgcattacta cgagaaaatg tgcatagcag    11640

aggaatattc aatagtctgt tagaattatc agggtcagtc atgcgaggcg cctctcctga    11700

gccccccagt gccctagaaa ctttaggagg agataaatcg agatgtgtaa atggtgaaac    11760

atgttgggaa tatccatctg acttatgtga cccaaggact tgggactatt tcctccgact    11820

caaagcaggc ttggggcttc aaattgattt aattgtaatg gatatggaag ttcgggattc    11880

ttctactagc ctgaaaattg agacgaatgt tagaaattat gtgcaccgga ttttggatga    11940

gcaaggagtt ttaatctaca agacttatgg aacatatatt tgtgagagcg aaaagaatgc    12000

agtaacaatc cttggtccca tgttcaagac ggtcgactta gttcaaacag aatttagtag    12060

ttctcaaacg tctgaagtat atatggtatg taaaggtttg aagaaattaa tcgatgaacc    12120

caatcccgat tggtcttcca tcaatgaatc ctggaaaaac ctgtacgcat tccagtcatc    12180

agaacaggaa tttgccagag caaagaaggt tagtacatac tttaccttga caggtattcc    12240

ctcccaattc attcctgatc cttttgtaaa cattgagact atgctacaaa tattcggagt    12300

acccacgggt gtgtctcatg cggctgcctt aaaatcatct gatagacctg cagatttatt    12360

gaccattagc cttttttata tggcgattat atcgtattat aacatcaatc atatcagagt    12420

aggaccgata cctccgaacc ccccatcaga tggaattgca caaaatgtgg ggatcgctat    12480

aactggtata agcttttggc tgagtttgat ggagaaagac attccactat atcaacagtg    12540

tttagcagtt atccagcaat cattcccgat taggtgggag gctgtttcag taaaaggagg    12600

atacaagcag aagtggagta ctagaggtga tgggctccca aaagataccc gaatttcaga    12660

ctccttggcc ccaatcggga actggatcag atctctggaa ttggtccgaa accaagttcg    12720

tctaaatcca ttcaatgaga tcttgttcaa tcagctatgt cgtacagtgg ataatcattt    12780

gaaatggtca aatttgcgaa gaaacacagg aatgattgaa tggatcaata gacgaatttc    12840

aaaagaagac cggtctatac tgatgttgaa gagtgaccta cacgaggaaa actcttggag    12900

agattaaaaa atcatgagga gactccaaac tttaagtatg aaaaaaactt tgatccttaa    12960

gaccctcttg tggtttttat tttttatctg gttttgtggt cttcgt                   13006


<210>  14
<211>  422
<212>  PRT
<213>  Vesicular stomatitis virus

<400>  14

Met Ser Val Thr Val Lys Arg Ile Ile Asp Asn Thr Val Ile Val Pro 
1               5                   10                  15      


Lys Leu Pro Ala Asn Glu Asp Pro Val Glu Tyr Pro Ala Asp Tyr Phe 
            20                  25                  30          


Arg Lys Ser Lys Glu Ile Pro Leu Tyr Ile Asn Thr Thr Lys Ser Leu 
        35                  40                  45              


Ser Asp Leu Arg Gly Tyr Val Tyr Gln Gly Leu Lys Ser Gly Asn Val 
    50                  55                  60                  


Ser Ile Ile His Val Asn Ser Tyr Leu Tyr Gly Ala Leu Lys Asp Ile 
65                  70                  75                  80  


Arg Gly Lys Leu Asp Lys Asp Trp Ser Ser Phe Gly Ile Asn Ile Gly 
                85                  90                  95      


Lys Ala Gly Asp Thr Ile Gly Ile Phe Asp Leu Val Ser Leu Lys Ala 
            100                 105                 110         


Leu Asp Gly Val Leu Pro Asp Gly Val Ser Asp Ala Ser Arg Thr Ser 
        115                 120                 125             


Ala Asp Asp Lys Trp Leu Pro Leu Tyr Leu Leu Gly Leu Tyr Arg Val 
    130                 135                 140                 


Gly Arg Thr Gln Met Pro Glu Tyr Arg Lys Lys Leu Met Asp Gly Leu 
145                 150                 155                 160 


Thr Asn Gln Cys Lys Met Ile Asn Glu Gln Phe Glu Pro Leu Val Pro 
                165                 170                 175     


Glu Gly Arg Asp Ile Phe Asp Val Trp Gly Asn Asp Ser Asn Tyr Thr 
            180                 185                 190         


Lys Ile Val Ala Ala Val Asp Met Phe Phe His Met Phe Lys Lys His 
        195                 200                 205             


Glu Cys Ala Ser Phe Arg Tyr Gly Thr Ile Val Ser Arg Phe Lys Asp 
    210                 215                 220                 


Cys Ala Ala Leu Ala Thr Phe Gly His Leu Cys Lys Ile Thr Gly Met 
225                 230                 235                 240 


Ser Thr Glu Asp Val Thr Thr Trp Ile Leu Asn Arg Glu Val Ala Asp 
                245                 250                 255     


Glu Met Val Gln Met Met Leu Pro Gly Gln Glu Ile Asp Lys Ala Asp 
            260                 265                 270         


Ser Tyr Met Pro Tyr Leu Ile Asp Phe Gly Leu Ser Ser Lys Ser Pro 
        275                 280                 285             


Tyr Ser Ser Val Lys Asn Pro Ala Phe His Phe Trp Gly Gln Leu Thr 
    290                 295                 300                 


Ala Leu Leu Leu Arg Ser Thr Arg Ala Arg Asn Ala Arg Gln Pro Asp 
305                 310                 315                 320 


Asp Ile Glu Tyr Thr Ser Leu Thr Thr Ala Gly Leu Leu Tyr Ala Tyr 
                325                 330                 335     


Ala Val Gly Ser Ser Ala Asp Leu Ala Gln Gln Phe Cys Val Gly Asp 
            340                 345                 350         


Asn Lys Tyr Thr Pro Asp Asp Ser Thr Gly Gly Leu Thr Thr Asn Ala 
        355                 360                 365             


Pro Pro Gln Gly Arg Asp Val Val Glu Trp Leu Gly Trp Phe Glu Asp 
    370                 375                 380                 


Gln Asn Arg Lys Pro Thr Pro Asp Met Met Gln Tyr Ala Lys Arg Ala 
385                 390                 395                 400 


Val Met Ser Leu Gln Gly Leu Arg Glu Lys Thr Ile Gly Lys Tyr Ala 
                405                 410                 415     


Lys Ser Glu Phe Asp Lys 
            420         


<210>  15
<211>  265
<212>  PRT
<213>  Vesicular stomatitis virus

<400>  15

Met Asp Asn Leu Thr Lys Val Arg Glu Tyr Leu Lys Ser Tyr Ser Arg 
1               5                   10                  15      


Leu Asp Gln Ala Val Gly Glu Ile Asp Glu Ile Glu Ala Gln Arg Ala 
            20                  25                  30          


Glu Lys Ser Asn Tyr Glu Leu Phe Gln Glu Asp Gly Val Glu Glu His 
        35                  40                  45              


Thr Lys Pro Ser Tyr Phe Gln Ala Ala Asp Asp Ser Asp Thr Glu Ser 
    50                  55                  60                  


Glu Pro Glu Ile Glu Asp Asn Gln Gly Leu Tyr Ala Gln Asp Pro Glu 
65                  70                  75                  80  


Ala Glu Gln Val Glu Gly Phe Ile Gln Gly Pro Leu Asp Asp Tyr Ala 
                85                  90                  95      


Asp Glu Glu Val Asp Val Val Phe Thr Ser Asp Trp Lys Pro Pro Glu 
            100                 105                 110         


Leu Glu Ser Asp Glu His Gly Lys Thr Leu Arg Leu Thr Ser Pro Glu 
        115                 120                 125             


Gly Leu Ser Gly Glu Gln Lys Ser Gln Trp Leu Ser Thr Ile Lys Ala 
    130                 135                 140                 


Val Val Gln Ser Ala Lys Tyr Trp Asn Leu Ala Glu Cys Thr Phe Glu 
145                 150                 155                 160 


Ala Ser Gly Glu Gly Val Ile Met Lys Glu Arg Gln Ile Thr Pro Asp 
                165                 170                 175     


Val Tyr Lys Val Thr Pro Val Met Asn Thr His Pro Ser Gln Ser Glu 
            180                 185                 190         


Ala Val Ser Asp Val Trp Ser Leu Ser Lys Thr Ser Met Thr Phe Gln 
        195                 200                 205             


Pro Lys Lys Ala Ser Leu Gln Pro Leu Thr Ile Ser Leu Asp Glu Leu 
    210                 215                 220                 


Phe Ser Ser Arg Gly Glu Phe Ile Ser Val Gly Gly Asp Gly Arg Met 
225                 230                 235                 240 


Ser His Lys Glu Ala Ile Leu Leu Gly Leu Arg Tyr Lys Lys Leu Tyr 
                245                 250                 255     


Asn Gln Ala Arg Val Lys Tyr Ser Leu 
            260                 265 


<210>  16
<211>  229
<212>  PRT
<213>  Vesicular stomatitis virus

<400>  16

Met Ser Ser Leu Lys Lys Ile Leu Gly Leu Lys Gly Lys Gly Lys Lys 
1               5                   10                  15      


Ser Lys Lys Leu Gly Ile Ala Pro Pro Pro Tyr Glu Glu Asp Thr Ser 
            20                  25                  30          


Met Glu Tyr Ala Pro Ser Ala Pro Ile Asp Lys Ser Tyr Phe Gly Val 
        35                  40                  45              


Asp Glu Met Asp Thr Tyr Asp Pro Asn Gln Leu Arg Tyr Glu Lys Phe 
    50                  55                  60                  


Phe Phe Thr Val Lys Met Thr Val Arg Ser Asn Arg Pro Phe Arg Thr 
65                  70                  75                  80  


Tyr Ser Asp Val Ala Ala Ala Val Ser His Trp Asp His Met Tyr Ile 
                85                  90                  95      


Gly Met Ala Gly Lys Arg Pro Phe Tyr Lys Ile Leu Ala Phe Leu Gly 
            100                 105                 110         


Ser Ser Asn Leu Lys Ala Thr Pro Ala Val Leu Ala Asp Gln Gly Gln 
        115                 120                 125             


Pro Glu Tyr His Thr His Cys Glu Gly Arg Ala Tyr Leu Pro His Arg 
    130                 135                 140                 


Met Gly Lys Thr Pro Pro Met Leu Asn Val Pro Glu His Phe Arg Arg 
145                 150                 155                 160 


Pro Phe Asn Ile Gly Leu Tyr Lys Gly Thr Ile Glu Leu Thr Met Thr 
                165                 170                 175     


Ile Tyr Asp Asp Glu Ser Leu Glu Ala Ala Pro Met Ile Trp Asp His 
            180                 185                 190         


Phe Asn Ser Ser Lys Phe Ser Asp Phe Arg Glu Lys Ala Leu Met Phe 
        195                 200                 205             


Gly Leu Ile Val Glu Lys Lys Ala Ser Gly Ala Trp Val Leu Asp Ser 
    210                 215                 220                 


Ile Ser His Phe Lys 
225                 


<210>  17
<211>  2109
<212>  PRT
<213>  Vesicular stomatitis virus

<400>  17

Met Glu Val His Asp Phe Glu Thr Asp Glu Phe Asn Asp Phe Asn Glu 
1               5                   10                  15      


Asp Asp Tyr Ala Thr Arg Glu Phe Leu Asn Pro Asp Glu Arg Met Thr 
            20                  25                  30          


Tyr Leu Asn His Ala Asp Tyr Asn Leu Asn Ser Pro Leu Ile Ser Asp 
        35                  40                  45              


Asp Ile Asp Asn Leu Ile Arg Lys Phe Asn Ser Leu Pro Ile Pro Ser 
    50                  55                  60                  


Met Trp Asp Ser Lys Asn Trp Asp Gly Val Leu Glu Met Leu Thr Ser 
65                  70                  75                  80  


Cys Gln Ala Asn Pro Ile Ser Thr Ser Gln Met His Lys Trp Met Gly 
                85                  90                  95      


Ser Trp Leu Met Ser Asp Asn His Asp Ala Ser Gln Gly Tyr Ser Phe 
            100                 105                 110         


Leu His Glu Val Asp Lys Glu Ala Glu Ile Thr Phe Asp Val Val Glu 
        115                 120                 125             


Thr Phe Ile Arg Gly Trp Gly Asn Lys Pro Ile Glu Tyr Ile Lys Lys 
    130                 135                 140                 


Glu Arg Trp Thr Asp Ser Phe Lys Ile Leu Ala Tyr Leu Cys Gln Lys 
145                 150                 155                 160 


Phe Leu Asp Leu His Lys Leu Thr Leu Ile Leu Asn Ala Val Ser Glu 
                165                 170                 175     


Val Glu Leu Leu Asn Leu Ala Arg Thr Phe Lys Gly Lys Val Arg Arg 
            180                 185                 190         


Ser Ser His Gly Thr Asn Ile Cys Arg Ile Arg Val Pro Ser Leu Gly 
        195                 200                 205             


Pro Thr Phe Ile Ser Glu Gly Trp Ala Tyr Phe Lys Lys Leu Asp Ile 
    210                 215                 220                 


Leu Met Asp Arg Asn Phe Leu Leu Met Val Lys Asp Val Ile Ile Gly 
225                 230                 235                 240 


Arg Met Gln Thr Val Leu Ser Met Val Cys Arg Ile Asp Asn Leu Phe 
                245                 250                 255     


Ser Glu Gln Asp Ile Phe Ser Leu Leu Asn Ile Tyr Arg Ile Gly Asp 
            260                 265                 270         


Lys Ile Val Glu Arg Gln Gly Asn Phe Ser Tyr Asp Leu Ile Lys Met 
        275                 280                 285             


Val Glu Pro Ile Cys Asn Leu Lys Leu Met Lys Leu Ala Arg Glu Ser 
    290                 295                 300                 


Arg Pro Leu Val Pro Gln Phe Pro His Phe Glu Asn His Ile Lys Thr 
305                 310                 315                 320 


Ser Val Asp Glu Gly Ala Lys Ile Asp Arg Gly Ile Arg Phe Leu His 
                325                 330                 335     


Asp Gln Ile Met Ser Val Lys Thr Val Asp Leu Thr Leu Val Ile Tyr 
            340                 345                 350         


Gly Ser Phe Arg His Trp Gly His Pro Phe Ile Asp Tyr Tyr Thr Gly 
        355                 360                 365             


Leu Glu Lys Leu His Ser Gln Val Thr Met Lys Lys Asp Ile Asp Val 
    370                 375                 380                 


Ser Tyr Ala Lys Ala Leu Ala Ser Asp Leu Ala Arg Ile Val Leu Phe 
385                 390                 395                 400 


Gln Gln Phe Asn Asp His Lys Lys Trp Phe Val Asn Gly Asp Leu Leu 
                405                 410                 415     


Pro His Asp His Pro Phe Lys Ser His Val Lys Glu Asn Thr Trp Pro 
            420                 425                 430         


Thr Ala Ala Gln Val Gln Asp Phe Gly Asp Lys Trp His Glu Leu Pro 
        435                 440                 445             


Leu Ile Lys Cys Phe Glu Ile Pro Asp Leu Leu Asp Pro Ser Ile Ile 
    450                 455                 460                 


Tyr Ser Asp Lys Ser His Ser Met Asn Arg Ser Glu Val Leu Lys His 
465                 470                 475                 480 


Val Arg Met Asn Pro Asn Thr Pro Ile Pro Ser Lys Lys Val Leu Gln 
                485                 490                 495     


Thr Met Leu Asp Thr Lys Ala Thr Asn Trp Lys Glu Phe Leu Lys Glu 
            500                 505                 510         


Ile Asp Glu Lys Gly Leu Asp Asp Asp Asp Leu Ile Ile Gly Leu Lys 
        515                 520                 525             


Gly Lys Glu Arg Glu Leu Lys Leu Ala Gly Arg Phe Phe Ser Leu Met 
    530                 535                 540                 


Ser Trp Lys Leu Arg Glu Tyr Phe Val Ile Thr Glu Tyr Leu Ile Lys 
545                 550                 555                 560 


Thr His Phe Val Pro Met Phe Lys Gly Leu Thr Met Ala Asp Asp Leu 
                565                 570                 575     


Thr Ala Val Ile Lys Lys Met Leu Asp Ser Ser Ser Gly Gln Gly Leu 
            580                 585                 590         


Lys Ser Tyr Glu Ala Ile Cys Ile Ala Asn His Ile Asp Tyr Glu Lys 
        595                 600                 605             


Trp Asn Asn His Gln Arg Lys Leu Ser Asn Gly Pro Val Phe Arg Val 
    610                 615                 620                 


Met Gly Gln Phe Leu Gly Tyr Pro Ser Leu Ile Glu Arg Thr His Glu 
625                 630                 635                 640 


Phe Phe Glu Lys Ser Leu Ile Tyr Tyr Asn Gly Arg Pro Asp Leu Met 
                645                 650                 655     


Arg Val His Asn Asn Thr Leu Ile Asn Ser Thr Ser Gln Arg Val Cys 
            660                 665                 670         


Trp Gln Gly Gln Glu Gly Gly Leu Glu Gly Leu Arg Gln Lys Gly Trp 
        675                 680                 685             


Thr Ile Leu Asn Leu Leu Val Ile Gln Arg Glu Ala Lys Ile Arg Asn 
    690                 695                 700                 


Thr Ala Val Lys Val Leu Ala Gln Gly Asp Asn Gln Val Ile Cys Thr 
705                 710                 715                 720 


Gln Tyr Lys Thr Lys Lys Ser Arg Asn Val Val Glu Leu Gln Gly Ala 
                725                 730                 735     


Leu Asn Gln Met Val Ser Asn Asn Glu Lys Ile Met Thr Ala Ile Lys 
            740                 745                 750         


Ile Gly Thr Gly Lys Leu Gly Leu Leu Ile Asn Asp Asp Glu Thr Met 
        755                 760                 765             


Gln Ser Ala Asp Tyr Leu Asn Tyr Gly Lys Ile Pro Ile Phe Arg Gly 
    770                 775                 780                 


Val Ile Arg Gly Leu Glu Thr Lys Arg Trp Ser Arg Val Thr Cys Val 
785                 790                 795                 800 


Thr Asn Asp Gln Ile Pro Thr Cys Ala Asn Ile Met Ser Ser Val Ser 
                805                 810                 815     


Thr Asn Ala Leu Thr Val Ala His Phe Ala Glu Asn Pro Ile Asn Ala 
            820                 825                 830         


Met Ile Gln Tyr Asn Tyr Phe Gly Thr Phe Ala Arg Leu Leu Leu Met 
        835                 840                 845             


Met His Asp Pro Ala Leu Arg Gln Ser Leu Tyr Glu Val Gln Asp Lys 
    850                 855                 860                 


Ile Pro Gly Leu His Ser Ser Thr Phe Lys Tyr Ala Met Leu Tyr Leu 
865                 870                 875                 880 


Asp Pro Ser Ile Gly Gly Val Ser Gly Met Ser Leu Ser Arg Phe Leu 
                885                 890                 895     


Ile Arg Ala Phe Pro Asp Pro Val Thr Glu Ser Leu Ser Phe Trp Arg 
            900                 905                 910         


Phe Ile His Val His Ala Arg Ser Glu His Leu Lys Glu Met Ser Ala 
        915                 920                 925             


Val Phe Gly Asn Pro Glu Ile Ala Lys Phe Arg Ile Thr His Ile Asp 
    930                 935                 940                 


Lys Leu Val Glu Asp Pro Thr Ser Leu Asn Ile Ala Met Gly Met Ser 
945                 950                 955                 960 


Pro Ala Asn Leu Leu Lys Thr Glu Val Lys Lys Cys Leu Ile Glu Ser 
                965                 970                 975     


Arg Gln Thr Ile Arg Asn Gln Val Ile Lys Asp Ala Thr Ile Tyr Leu 
            980                 985                 990         


Tyr His Glu Glu Asp Arg Leu Arg  Ser Phe Leu Trp Ser  Ile Asn Pro 
        995                 1000                 1005             


Leu Phe  Pro Arg Phe Leu Ser  Glu Phe Lys Ser Gly  Thr Phe Leu 
    1010                 1015                 1020             


Gly Val  Ala Asp Gly Leu Ile  Ser Leu Phe Gln Asn  Ser Arg Thr 
    1025                 1030                 1035             


Ile Arg  Asn Ser Phe Lys Lys  Lys Tyr His Arg Glu  Leu Asp Asp 
    1040                 1045                 1050             


Leu Ile  Val Arg Ser Glu Val  Ser Ser Leu Thr His  Leu Gly Lys 
    1055                 1060                 1065             


Leu His  Leu Arg Arg Gly Ser  Cys Lys Met Trp Thr  Cys Ser Ala 
    1070                 1075                 1080             


Thr His  Ala Asp Thr Leu Arg  Tyr Lys Ser Trp Gly  Arg Thr Val 
    1085                 1090                 1095             


Ile Gly  Thr Thr Val Pro His  Pro Leu Glu Met Leu  Gly Pro Gln 
    1100                 1105                 1110             


His Arg  Lys Glu Thr Pro Cys  Ala Pro Cys Asn Thr  Ser Gly Phe 
    1115                 1120                 1125             


Asn Tyr  Val Ser Val His Cys  Pro Asp Gly Ile His  Asp Val Phe 
    1130                 1135                 1140             


Ser Ser  Arg Gly Pro Leu Pro  Ala Tyr Leu Gly Ser  Lys Thr Ser 
    1145                 1150                 1155             


Glu Ser  Thr Ser Ile Leu Gln  Pro Trp Glu Arg Glu  Ser Lys Val 
    1160                 1165                 1170             


Pro Leu  Ile Lys Arg Ala Thr  Arg Leu Arg Asp Ala  Ile Ser Trp 
    1175                 1180                 1185             


Phe Val  Glu Pro Asp Ser Lys  Leu Ala Met Thr Ile  Leu Ser Asn 
    1190                 1195                 1200             


Ile His  Ser Leu Thr Gly Glu  Glu Trp Thr Lys Arg  Gln His Gly 
    1205                 1210                 1215             


Phe Lys  Arg Thr Gly Ser Ala  Leu His Arg Phe Ser  Thr Ser Arg 
    1220                 1225                 1230             


Met Ser  His Gly Gly Phe Ala  Ser Gln Ser Thr Ala  Ala Leu Thr 
    1235                 1240                 1245             


Arg Leu  Met Ala Thr Thr Asp  Thr Met Arg Asp Leu  Gly Asp Gln 
    1250                 1255                 1260             


Asn Phe  Asp Phe Leu Phe Gln  Ala Thr Leu Leu Tyr  Ala Gln Ile 
    1265                 1270                 1275             


Thr Thr  Thr Val Ala Arg Asp  Gly Trp Ile Thr Ser  Cys Thr Asp 
    1280                 1285                 1290             


His Tyr  His Ile Ala Cys Lys  Ser Cys Leu Arg Pro  Ile Glu Glu 
    1295                 1300                 1305             


Ile Thr  Leu Asp Ser Ser Met  Asp Tyr Thr Pro Pro  Asp Val Ser 
    1310                 1315                 1320             


His Val  Leu Lys Thr Trp Arg  Asn Gly Glu Gly Ser  Trp Gly Gln 
    1325                 1330                 1335             


Glu Ile  Lys Gln Ile Tyr Pro  Leu Glu Gly Asn Trp  Lys Asn Leu 
    1340                 1345                 1350             


Ala Pro  Ala Glu Gln Ser Tyr  Gln Val Gly Arg Cys  Ile Gly Phe 
    1355                 1360                 1365             


Leu Tyr  Gly Asp Leu Ala Tyr  Arg Lys Ser Thr His  Ala Glu Asp 
    1370                 1375                 1380             


Ser Ser  Leu Phe Pro Leu Ser  Ile Gln Gly Arg Ile  Arg Gly Arg 
    1385                 1390                 1395             


Gly Phe  Leu Lys Gly Leu Leu  Asp Gly Leu Met Arg  Ala Ser Cys 
    1400                 1405                 1410             


Cys Gln  Val Ile His Arg Arg  Ser Leu Ala His Leu  Lys Arg Pro 
    1415                 1420                 1425             


Ala Asn  Ala Val Tyr Gly Gly  Leu Ile Tyr Leu Ile  Asp Lys Leu 
    1430                 1435                 1440             


Ser Val  Ser Pro Pro Phe Leu  Ser Leu Thr Arg Ser  Gly Pro Ile 
    1445                 1450                 1455             


Arg Asp  Glu Leu Glu Thr Ile  Pro His Lys Ile Pro  Thr Ser Tyr 
    1460                 1465                 1470             


Pro Thr  Ser Asn Arg Asp Met  Gly Val Ile Val Arg  Asn Tyr Phe 
    1475                 1480                 1485             


Lys Tyr  Gln Cys Arg Leu Ile  Glu Lys Gly Lys Tyr  Arg Ser His 
    1490                 1495                 1500             


Tyr Ser  Gln Leu Trp Leu Phe  Ser Asp Val Leu Ser  Ile Asp Phe 
    1505                 1510                 1515             


Ile Gly  Pro Phe Ser Ile Ser  Thr Thr Leu Leu Gln  Ile Leu Tyr 
    1520                 1525                 1530             


Lys Pro  Phe Leu Ser Gly Lys  Asp Lys Asn Glu Leu  Arg Glu Leu 
    1535                 1540                 1545             


Ala Asn  Leu Ser Ser Leu Leu  Arg Ser Gly Glu Gly  Trp Glu Asp 
    1550                 1555                 1560             


Ile His  Val Lys Phe Phe Thr  Lys Asp Ile Leu Leu  Cys Pro Glu 
    1565                 1570                 1575             


Glu Ile  Arg His Ala Cys Lys  Phe Gly Ile Ala Lys  Asp Asn Asn 
    1580                 1585                 1590             


Lys Asp  Met Ser Tyr Pro Pro  Trp Gly Arg Glu Ser  Arg Gly Thr 
    1595                 1600                 1605             


Ile Thr  Thr Ile Pro Val Tyr  Tyr Thr Thr Thr Pro  Tyr Pro Lys 
    1610                 1615                 1620             


Met Leu  Glu Met Pro Pro Arg  Ile Gln Asn Pro Leu  Leu Ser Gly 
    1625                 1630                 1635             


Ile Arg  Leu Gly Gln Leu Pro  Thr Gly Ala His Tyr  Lys Ile Arg 
    1640                 1645                 1650             


Ser Ile  Leu His Gly Met Gly  Ile His Tyr Arg Asp  Phe Leu Ser 
    1655                 1660                 1665             


Cys Gly  Asp Gly Ser Gly Gly  Met Thr Ala Ala Leu  Leu Arg Glu 
    1670                 1675                 1680             


Asn Val  His Ser Arg Gly Ile  Phe Asn Ser Leu Leu  Glu Leu Ser 
    1685                 1690                 1695             


Gly Ser  Val Met Arg Gly Ala  Ser Pro Glu Pro Pro  Ser Ala Leu 
    1700                 1705                 1710             


Glu Thr  Leu Gly Gly Asp Lys  Ser Arg Cys Val Asn  Gly Glu Thr 
    1715                 1720                 1725             


Cys Trp  Glu Tyr Pro Ser Asp  Leu Cys Asp Pro Arg  Thr Trp Asp 
    1730                 1735                 1740             


Tyr Phe  Leu Arg Leu Lys Ala  Gly Leu Gly Leu Gln  Ile Asp Leu 
    1745                 1750                 1755             


Ile Val  Met Asp Met Glu Val  Arg Asp Ser Ser Thr  Ser Leu Lys 
    1760                 1765                 1770             


Ile Glu  Thr Asn Val Arg Asn  Tyr Val His Arg Ile  Leu Asp Glu 
    1775                 1780                 1785             


Gln Gly  Val Leu Ile Tyr Lys  Thr Tyr Gly Thr Tyr  Ile Cys Glu 
    1790                 1795                 1800             


Ser Glu  Lys Asn Ala Val Thr  Ile Leu Gly Pro Met  Phe Lys Thr 
    1805                 1810                 1815             


Val Asp  Leu Val Gln Thr Glu  Phe Ser Ser Ser Gln  Thr Ser Glu 
    1820                 1825                 1830             


Val Tyr  Met Val Cys Lys Gly  Leu Lys Lys Leu Ile  Asp Glu Pro 
    1835                 1840                 1845             


Asn Pro  Asp Trp Ser Ser Ile  Asn Glu Ser Trp Lys  Asn Leu Tyr 
    1850                 1855                 1860             


Ala Phe  Gln Ser Ser Glu Gln  Glu Phe Ala Arg Ala  Lys Lys Val 
    1865                 1870                 1875             


Ser Thr  Tyr Phe Thr Leu Thr  Gly Ile Pro Ser Gln  Phe Ile Pro 
    1880                 1885                 1890             


Asp Pro  Phe Val Asn Ile Glu  Thr Met Leu Gln Ile  Phe Gly Val 
    1895                 1900                 1905             


Pro Thr  Gly Val Ser His Ala  Ala Ala Leu Lys Ser  Ser Asp Arg 
    1910                 1915                 1920             


Pro Ala  Asp Leu Leu Thr Ile  Ser Leu Phe Tyr Met  Ala Ile Ile 
    1925                 1930                 1935             


Ser Tyr  Tyr Asn Ile Asn His  Ile Arg Val Gly Pro  Ile Pro Pro 
    1940                 1945                 1950             


Asn Pro  Pro Ser Asp Gly Ile  Ala Gln Asn Val Gly  Ile Ala Ile 
    1955                 1960                 1965             


Thr Gly  Ile Ser Phe Trp Leu  Ser Leu Met Glu Lys  Asp Ile Pro 
    1970                 1975                 1980             


Leu Tyr  Gln Gln Cys Leu Ala  Val Ile Gln Gln Ser  Phe Pro Ile 
    1985                 1990                 1995             


Arg Trp  Glu Ala Val Ser Val  Lys Gly Gly Tyr Lys  Gln Lys Trp 
    2000                 2005                 2010             


Ser Thr  Arg Gly Asp Gly Leu  Pro Lys Asp Thr Arg  Thr Ser Asp 
    2015                 2020                 2025             


Ser Leu  Ala Pro Ile Gly Asn  Trp Ile Arg Ser Leu  Glu Leu Val 
    2030                 2035                 2040             


Arg Asn  Gln Val Arg Leu Asn  Pro Phe Asn Glu Ile  Leu Phe Asn 
    2045                 2050                 2055             


Gln Leu  Cys Arg Thr Val Asp  Asn His Leu Lys Trp  Ser Asn Leu 
    2060                 2065                 2070             


Arg Arg  Asn Thr Gly Met Ile  Glu Trp Ile Asn Arg  Arg Ile Ser 
    2075                 2080                 2085             


Lys Glu  Asp Arg Ser Ile Leu  Met Leu Lys Ser Asp  Leu His Glu 
    2090                 2095                 2100             


Glu Asn  Ser Trp Arg Asp 
    2105                 


