                         SEQUENCE LISTING

<110>  Istituto Nazionale di Genetica Molecolare - INGM
       Universit degli Studi di Milano
 
<120>  Cancer Treatment

<130>  PCT 132793

<150>  EP16169791.7
<151>  2016-05-16

<150>  EP16198724.3
<151>  2016-11-14

<160>  791   

<170>  PatentIn version 3.5

<210>  1
<211>  374
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Arg Pro Gly Thr Ala Leu Gln Ala Val Leu Leu Ala Val Leu Leu 
1               5                   10                  15      


Val Gly Leu Arg Ala Ala Thr Gly Arg Leu Leu Ser Gly Gln Pro Val 
            20                  25                  30          


Cys Arg Gly Gly Thr Gln Arg Pro Cys Tyr Lys Val Ile Tyr Phe His 
        35                  40                  45              


Asp Thr Ser Arg Arg Leu Asn Phe Glu Glu Ala Lys Glu Ala Cys Arg 
    50                  55                  60                  


Arg Asp Gly Gly Gln Leu Val Ser Ile Glu Ser Glu Asp Glu Gln Lys 
65                  70                  75                  80  


Leu Ile Glu Lys Phe Ile Glu Asn Leu Leu Pro Ser Asp Gly Asp Phe 
                85                  90                  95      


Trp Ile Gly Leu Arg Arg Arg Glu Glu Lys Gln Ser Asn Ser Thr Ala 
            100                 105                 110         


Cys Gln Asp Leu Tyr Ala Trp Thr Asp Gly Ser Ile Ser Gln Phe Arg 
        115                 120                 125             


Asn Trp Tyr Val Asp Glu Pro Ser Cys Gly Ser Glu Val Cys Val Val 
    130                 135                 140                 


Met Tyr His Gln Pro Ser Ala Pro Ala Gly Ile Gly Gly Pro Tyr Met 
145                 150                 155                 160 


Phe Gln Trp Asn Asp Asp Arg Cys Asn Met Lys Asn Asn Phe Ile Cys 
                165                 170                 175     


Lys Tyr Ser Asp Glu Lys Pro Ala Val Pro Ser Arg Glu Ala Glu Gly 
            180                 185                 190         


Glu Glu Thr Glu Leu Thr Thr Pro Val Leu Pro Glu Glu Thr Gln Glu 
        195                 200                 205             


Glu Asp Ala Lys Lys Thr Phe Lys Glu Ser Arg Glu Ala Ala Leu Asn 
    210                 215                 220                 


Leu Ala Tyr Ile Leu Ile Pro Ser Ile Pro Leu Leu Leu Leu Leu Val 
225                 230                 235                 240 


Val Thr Thr Val Val Cys Trp Val Trp Ile Cys Arg Lys Arg Lys Arg 
                245                 250                 255     


Glu Gln Pro Asp Pro Ser Thr Lys Lys Gln His Thr Ile Trp Pro Ser 
            260                 265                 270         


Pro His Gln Gly Asn Ser Pro Asp Leu Glu Val Tyr Asn Val Ile Arg 
        275                 280                 285             


Lys Gln Ser Glu Ala Asp Leu Ala Glu Thr Arg Pro Asp Leu Lys Asn 
    290                 295                 300                 


Ile Ser Phe Arg Val Cys Ser Gly Glu Ala Thr Pro Asp Asp Met Ser 
305                 310                 315                 320 


Cys Asp Tyr Asp Asn Met Ala Val Asn Pro Ser Glu Ser Gly Phe Val 
                325                 330                 335     


Thr Leu Val Ser Val Glu Ser Gly Phe Val Thr Asn Asp Ile Tyr Glu 
            340                 345                 350         


Phe Ser Pro Asp Gln Met Gly Arg Ser Lys Glu Ser Gly Trp Val Glu 
        355                 360                 365             


Asn Glu Ile Tyr Gly Tyr 
    370                 


<210>  2
<211>  382
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Arg Pro Gly Thr Ala Leu Gln Ala Val Leu Leu Ala Val Leu Leu 
1               5                   10                  15      


Val Gly Leu Arg Ala Ala Thr Gly Arg Leu Leu Ser Ala Ser Asp Leu 
            20                  25                  30          


Asp Leu Arg Gly Gly Gln Pro Val Cys Arg Gly Gly Thr Gln Arg Pro 
        35                  40                  45              


Cys Tyr Lys Val Ile Tyr Phe His Asp Thr Ser Arg Arg Leu Asn Phe 
    50                  55                  60                  


Glu Glu Ala Lys Glu Ala Cys Arg Arg Asp Gly Gly Gln Leu Val Ser 
65                  70                  75                  80  


Ile Glu Ser Glu Asp Glu Gln Lys Leu Ile Glu Lys Phe Ile Glu Asn 
                85                  90                  95      


Leu Leu Pro Ser Asp Gly Asp Phe Trp Ile Gly Leu Arg Arg Arg Glu 
            100                 105                 110         


Glu Lys Gln Ser Asn Ser Thr Ala Cys Gln Asp Leu Tyr Ala Trp Thr 
        115                 120                 125             


Asp Gly Ser Ile Ser Gln Phe Arg Asn Trp Tyr Val Asp Glu Pro Ser 
    130                 135                 140                 


Cys Gly Ser Glu Val Cys Val Val Met Tyr His Gln Pro Ser Ala Pro 
145                 150                 155                 160 


Ala Gly Ile Gly Gly Pro Tyr Met Phe Gln Trp Asn Asp Asp Arg Cys 
                165                 170                 175     


Asn Met Lys Asn Asn Phe Ile Cys Lys Tyr Ser Asp Glu Lys Pro Ala 
            180                 185                 190         


Val Pro Ser Arg Glu Ala Glu Gly Glu Glu Thr Glu Leu Thr Thr Pro 
        195                 200                 205             


Val Leu Pro Glu Glu Thr Gln Glu Glu Asp Ala Lys Lys Thr Phe Lys 
    210                 215                 220                 


Glu Ser Arg Glu Ala Ala Leu Asn Leu Ala Tyr Ile Leu Ile Pro Ser 
225                 230                 235                 240 


Ile Pro Leu Leu Leu Leu Leu Val Val Thr Thr Val Val Cys Trp Val 
                245                 250                 255     


Trp Ile Cys Arg Lys Arg Lys Arg Glu Gln Pro Asp Pro Ser Thr Lys 
            260                 265                 270         


Lys Gln His Thr Ile Trp Pro Ser Pro His Gln Gly Asn Ser Pro Asp 
        275                 280                 285             


Leu Glu Val Tyr Asn Val Ile Arg Lys Gln Ser Glu Ala Asp Leu Ala 
    290                 295                 300                 


Glu Thr Arg Pro Asp Leu Lys Asn Ile Ser Phe Arg Val Cys Ser Gly 
305                 310                 315                 320 


Glu Ala Thr Pro Asp Asp Met Ser Cys Asp Tyr Asp Asn Met Ala Val 
                325                 330                 335     


Asn Pro Ser Glu Ser Gly Phe Val Thr Leu Val Ser Val Glu Ser Gly 
            340                 345                 350         


Phe Val Thr Asn Asp Ile Tyr Glu Phe Ser Pro Asp Gln Met Gly Arg 
        355                 360                 365             


Ser Lys Glu Ser Gly Trp Val Glu Asn Glu Ile Tyr Gly Tyr 
    370                 375                 380         


<210>  3
<211>  229
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Val Thr Ser Gly Leu Gly Ser Gly Gly Val Arg Arg Asn Lys Ala 
1               5                   10                  15      


Ile Ala Gln Pro Ala Arg Thr Phe Met Leu Gly Leu Met Ala Ala Tyr 
            20                  25                  30          


His Asn Leu Glu Lys Pro Ala Val Pro Ser Arg Glu Ala Glu Gly Glu 
        35                  40                  45              


Glu Thr Glu Leu Thr Thr Pro Val Leu Pro Glu Glu Thr Gln Glu Glu 
    50                  55                  60                  


Asp Ala Lys Lys Thr Phe Lys Glu Ser Arg Glu Ala Ala Leu Asn Leu 
65                  70                  75                  80  


Ala Tyr Ile Leu Ile Pro Ser Ile Pro Leu Leu Leu Leu Leu Val Val 
                85                  90                  95      


Thr Thr Val Val Cys Trp Val Trp Ile Cys Arg Lys Arg Lys Arg Glu 
            100                 105                 110         


Gln Pro Asp Pro Ser Thr Lys Lys Gln His Thr Ile Trp Pro Ser Pro 
        115                 120                 125             


His Gln Gly Asn Ser Pro Asp Leu Glu Val Tyr Asn Val Ile Arg Lys 
    130                 135                 140                 


Gln Ser Glu Ala Asp Leu Ala Glu Thr Arg Pro Asp Leu Lys Asn Ile 
145                 150                 155                 160 


Ser Phe Arg Val Cys Ser Gly Glu Ala Thr Pro Asp Asp Met Ser Cys 
                165                 170                 175     


Asp Tyr Asp Asn Met Ala Val Asn Pro Ser Glu Ser Gly Phe Val Thr 
            180                 185                 190         


Leu Val Ser Val Glu Ser Gly Phe Val Thr Asn Asp Ile Tyr Glu Phe 
        195                 200                 205             


Ser Pro Asp Gln Met Gly Arg Ser Lys Glu Ser Gly Trp Val Glu Asn 
    210                 215                 220                 


Glu Ile Tyr Gly Tyr 
225                 


<210>  4
<211>  270
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Arg Pro Gly Thr Ala Leu Gln Ala Val Leu Leu Ala Val Leu Leu 
1               5                   10                  15      


Val Gly Leu Arg Ala Ala Thr Gly Arg Leu Leu Ser Ala Ser Asp Leu 
            20                  25                  30          


Asp Leu Arg Gly Gly Gln Pro Val Cys Arg Gly Gly Thr Gln Arg Pro 
        35                  40                  45              


Cys Tyr Lys Val Ile Tyr Phe His Asp Thr Ser Arg Arg Leu Asn Phe 
    50                  55                  60                  


Glu Glu Ala Lys Glu Ala Cys Arg Arg Asp Gly Gly Gln Leu Val Ser 
65                  70                  75                  80  


Ile Glu Ser Glu Asp Glu Gln Lys Leu Ile Glu Lys Phe Ile Glu Asn 
                85                  90                  95      


Leu Leu Pro Ser Asp Gly Asp Phe Trp Ile Gly Leu Arg Arg Arg Glu 
            100                 105                 110         


Glu Lys Gln Ser Asn Ser Thr Ala Cys Gln Asp Leu Tyr Ala Trp Thr 
        115                 120                 125             


Asp Gly Ser Ile Ser Gln Phe Arg Asn Trp Tyr Val Asp Glu Pro Ser 
    130                 135                 140                 


Cys Gly Ser Glu Val Cys Val Val Met Tyr His Gln Pro Ser Ala Pro 
145                 150                 155                 160 


Ala Gly Ile Gly Gly Pro Tyr Met Phe Gln Trp Asn Asp Asp Arg Cys 
                165                 170                 175     


Asn Met Lys Asn Asn Phe Ile Cys Lys Tyr Ser Asp Glu Lys Pro Ala 
            180                 185                 190         


Val Pro Ser Arg Glu Ala Glu Gly Glu Glu Thr Glu Leu Thr Thr Pro 
        195                 200                 205             


Val Leu Pro Glu Glu Thr Gln Glu Glu Asp Ala Lys Lys Thr Phe Lys 
    210                 215                 220                 


Glu Ser Arg Glu Ala Ala Leu Asn Leu Ala Tyr Ile Leu Ile Pro Ser 
225                 230                 235                 240 


Ile Pro Leu Leu Leu Leu Leu Val Val Thr Thr Val Val Cys Trp Val 
                245                 250                 255     


Trp Ile Cys Arg Lys Arg Gln Lys Thr Gly Ala Ala Arg Pro 
            260                 265                 270 


<210>  5
<211>  134
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Arg Pro Gly Thr Ala Leu Gln Ala Val Leu Leu Ala Val Leu Leu 
1               5                   10                  15      


Val Gly Leu Arg Ala Ala Thr Gly Arg Leu Leu Ser Gly Gln Pro Val 
            20                  25                  30          


Cys Arg Gly Gly Thr Gln Arg Pro Cys Tyr Lys Val Ile Tyr Phe His 
        35                  40                  45              


Asp Thr Ser Arg Arg Leu Asn Phe Glu Glu Ala Lys Glu Ala Cys Arg 
    50                  55                  60                  


Arg Asp Gly Gly Gln Leu Val Ser Ile Glu Ser Glu Asp Glu Gln Lys 
65                  70                  75                  80  


Leu Ile Glu Lys Phe Ile Glu Asn Leu Leu Pro Ser Asp Gly Asp Phe 
                85                  90                  95      


Trp Ile Gly Leu Arg Arg Arg Glu Glu Lys Gln Ser Asn Ser Thr Ala 
            100                 105                 110         


Cys Gln Asp Leu Tyr Ala Trp Thr Asp Gly Ser Ile Ser Gln Phe Arg 
        115                 120                 125             


Glu Thr Ser Ser Ser Phe 
    130                 


<210>  6
<211>  108
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Val Thr Ser Gly Leu Gly Ser Gly Gly Val Arg Arg Asn Lys Ala 
1               5                   10                  15      


Ile Ala Gln Pro Ala Arg Thr Phe Met Leu Gly Leu Met Ala Ala Tyr 
            20                  25                  30          


His Asn Leu Glu Lys Pro Ala Val Pro Ser Arg Glu Ala Glu Gly Glu 
        35                  40                  45              


Glu Thr Glu Leu Thr Thr Pro Val Leu Pro Glu Glu Thr Gln Glu Glu 
    50                  55                  60                  


Asp Ala Lys Lys Thr Phe Lys Glu Ser Arg Glu Ala Ala Leu Asn Leu 
65                  70                  75                  80  


Ala Tyr Ile Leu Ile Pro Ser Ile Pro Leu Leu Leu Leu Leu Val Val 
                85                  90                  95      


Thr Thr Val Val Cys Trp Val Trp Ile Cys Arg Lys 
            100                 105             


<210>  7
<211>  109
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Tyr His Gln Pro Ser Ala Pro Ala Gly Ile Gly Gly Pro Tyr Met 
1               5                   10                  15      


Phe Gln Trp Asn Asp Asp Arg Cys Asn Met Lys Asn Asn Phe Ile Cys 
            20                  25                  30          


Lys Tyr Ser Asp Glu Lys Pro Ala Val Pro Ser Arg Glu Ala Glu Gly 
        35                  40                  45              


Glu Glu Thr Glu Leu Thr Thr Pro Val Leu Pro Glu Glu Thr Gln Glu 
    50                  55                  60                  


Glu Asp Ala Lys Lys Thr Phe Lys Glu Ser Arg Glu Ala Ala Leu Asn 
65                  70                  75                  80  


Leu Ala Tyr Ile Leu Ile Pro Ser Ile Pro Leu Leu Leu Leu Leu Val 
                85                  90                  95      


Val Thr Thr Val Val Cys Trp Val Trp Ile Cys Arg Lys 
            100                 105                 


<210>  8
<211>  262
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Arg Pro Gly Thr Ala Leu Gln Ala Val Leu Leu Ala Val Leu Leu 
1               5                   10                  15      


Val Gly Leu Arg Ala Ala Thr Gly Arg Leu Leu Ser Gly Gln Pro Val 
            20                  25                  30          


Cys Arg Gly Gly Thr Gln Arg Pro Cys Tyr Lys Val Ile Tyr Phe His 
        35                  40                  45              


Asp Thr Ser Arg Arg Leu Asn Phe Glu Glu Ala Lys Glu Ala Cys Arg 
    50                  55                  60                  


Arg Asp Gly Gly Gln Leu Val Ser Ile Glu Ser Glu Asp Glu Gln Lys 
65                  70                  75                  80  


Leu Ile Glu Lys Phe Ile Glu Asn Leu Leu Pro Ser Asp Gly Asp Phe 
                85                  90                  95      


Trp Ile Gly Leu Arg Arg Arg Glu Glu Lys Gln Ser Asn Ser Thr Ala 
            100                 105                 110         


Cys Gln Asp Leu Tyr Ala Trp Thr Asp Gly Ser Ile Ser Gln Phe Arg 
        115                 120                 125             


Asn Trp Tyr Val Asp Glu Pro Ser Cys Gly Ser Glu Val Cys Val Val 
    130                 135                 140                 


Met Tyr His Gln Pro Ser Ala Pro Ala Gly Ile Gly Gly Pro Tyr Met 
145                 150                 155                 160 


Phe Gln Trp Asn Asp Asp Arg Cys Asn Met Lys Asn Asn Phe Ile Cys 
                165                 170                 175     


Lys Tyr Ser Asp Glu Lys Pro Ala Val Pro Ser Arg Glu Ala Glu Gly 
            180                 185                 190         


Glu Glu Thr Glu Leu Thr Thr Pro Val Leu Pro Glu Glu Thr Gln Glu 
        195                 200                 205             


Glu Asp Ala Lys Lys Thr Phe Lys Glu Ser Arg Glu Ala Ala Leu Asn 
    210                 215                 220                 


Leu Ala Tyr Ile Leu Ile Pro Ser Ile Pro Leu Leu Leu Leu Leu Val 
225                 230                 235                 240 


Val Thr Thr Val Val Cys Trp Val Trp Ile Cys Arg Lys Arg Gln Lys 
                245                 250                 255     


Thr Gly Ala Ala Arg Pro 
            260         


<210>  9
<211>  49
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Tyr His Gln Pro Ser Ala Pro Ala Gly Ile Gly Gly Pro Tyr Met 
1               5                   10                  15      


Phe Gln Trp Asn Asp Asp Arg Cys Asn Met Lys Asn Asn Phe Ile Cys 
            20                  25                  30          


Lys Tyr Ser Asp Glu Lys Pro Ala Val Pro Ser Arg Glu Ala Glu Gly 
        35                  40                  45              


Glu 
    


<210>  10
<211>  355
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Asp Tyr Thr Leu Asp Leu Ser Val Thr Thr Val Thr Asp Tyr Tyr 
1               5                   10                  15      


Tyr Pro Asp Ile Phe Ser Ser Pro Cys Asp Ala Glu Leu Ile Gln Thr 
            20                  25                  30          


Asn Gly Lys Leu Leu Leu Ala Val Phe Tyr Cys Leu Leu Phe Val Phe 
        35                  40                  45              


Ser Leu Leu Gly Asn Ser Leu Val Ile Leu Val Leu Val Val Cys Lys 
    50                  55                  60                  


Lys Leu Arg Ser Ile Thr Asp Val Tyr Leu Leu Asn Leu Ala Leu Ser 
65                  70                  75                  80  


Asp Leu Leu Phe Val Phe Ser Phe Pro Phe Gln Thr Tyr Tyr Leu Leu 
                85                  90                  95      


Asp Gln Trp Val Phe Gly Thr Val Met Cys Lys Val Val Ser Gly Phe 
            100                 105                 110         


Tyr Tyr Ile Gly Phe Tyr Ser Ser Met Phe Phe Ile Thr Leu Met Ser 
        115                 120                 125             


Val Asp Arg Tyr Leu Ala Val Val His Ala Val Tyr Ala Leu Lys Val 
    130                 135                 140                 


Arg Thr Ile Arg Met Gly Thr Thr Leu Cys Leu Ala Val Trp Leu Thr 
145                 150                 155                 160 


Ala Ile Met Ala Thr Ile Pro Leu Leu Val Phe Tyr Gln Val Ala Ser 
                165                 170                 175     


Glu Asp Gly Val Leu Gln Cys Tyr Ser Phe Tyr Asn Gln Gln Thr Leu 
            180                 185                 190         


Lys Trp Lys Ile Phe Thr Asn Phe Lys Met Asn Ile Leu Gly Leu Leu 
        195                 200                 205             


Ile Pro Phe Thr Ile Phe Met Phe Cys Tyr Ile Lys Ile Leu His Gln 
    210                 215                 220                 


Leu Lys Arg Cys Gln Asn His Asn Lys Thr Lys Ala Ile Arg Leu Val 
225                 230                 235                 240 


Leu Ile Val Val Ile Ala Ser Leu Leu Phe Trp Val Pro Phe Asn Val 
                245                 250                 255     


Val Leu Phe Leu Thr Ser Leu His Ser Met His Ile Leu Asp Gly Cys 
            260                 265                 270         


Ser Ile Ser Gln Gln Leu Thr Tyr Ala Thr His Val Thr Glu Ile Ile 
        275                 280                 285             


Ser Phe Thr His Cys Cys Val Asn Pro Val Ile Tyr Ala Phe Val Gly 
    290                 295                 300                 


Glu Lys Phe Lys Lys His Leu Ser Glu Ile Phe Gln Lys Ser Cys Ser 
305                 310                 315                 320 


Gln Ile Phe Asn Tyr Leu Gly Arg Gln Met Pro Arg Glu Ser Cys Glu 
                325                 330                 335     


Lys Ser Ser Ser Cys Gln Gln His Ser Ser Arg Ser Ser Ser Val Asp 
            340                 345                 350         


Tyr Ile Leu 
        355 


<210>  11
<211>  118
<212>  PRT
<213>  Homo sapiens

<400>  11

Met Asp Tyr Thr Leu Asp Leu Ser Val Thr Thr Val Thr Asp Tyr Tyr 
1               5                   10                  15      


Tyr Pro Asp Ile Phe Ser Ser Pro Cys Asp Ala Glu Leu Ile Gln Thr 
            20                  25                  30          


Asn Asp Leu Leu Ser Ala Gly Pro Val Gly Val Trp Asp Cys Asn Val 
        35                  40                  45              


Gln Ser Gly Val Trp Leu Leu Leu His Trp Leu Leu Gln Gln His Val 
    50                  55                  60                  


Phe His His Pro His Glu Cys Gly Gln Val Pro Gly Cys Cys Pro Cys 
65                  70                  75                  80  


Arg Val Cys Pro Lys Gly Glu Asp Asp Gln Asp Gly His Asn Ala Val 
                85                  90                  95      


Pro Gly Ser Met Ala Asn Arg His Tyr Gly Tyr His Pro Ile Ala Ser 
            100                 105                 110         


Val Leu Pro Ser Gly Leu 
        115             


<210>  12
<211>  538
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Pro Arg Gly Trp Ala Ala Pro Leu Leu Leu Leu Leu Leu Gln Gly 
1               5                   10                  15      


Gly Trp Gly Cys Pro Asp Leu Val Cys Tyr Thr Asp Tyr Leu Gln Thr 
            20                  25                  30          


Val Ile Cys Ile Leu Glu Met Trp Asn Leu His Pro Ser Thr Leu Thr 
        35                  40                  45              


Leu Thr Trp Gln Asp Gln Tyr Glu Glu Leu Lys Asp Glu Ala Thr Ser 
    50                  55                  60                  


Cys Ser Leu His Arg Ser Ala His Asn Ala Thr His Ala Thr Tyr Thr 
65                  70                  75                  80  


Cys His Met Asp Val Phe His Phe Met Ala Asp Asp Ile Phe Ser Val 
                85                  90                  95      


Asn Ile Thr Asp Gln Ser Gly Asn Tyr Ser Gln Glu Cys Gly Ser Phe 
            100                 105                 110         


Leu Leu Ala Glu Ser Ile Lys Pro Ala Pro Pro Phe Asn Val Thr Val 
        115                 120                 125             


Thr Phe Ser Gly Gln Tyr Asn Ile Ser Trp Arg Ser Asp Tyr Glu Asp 
    130                 135                 140                 


Pro Ala Phe Tyr Met Leu Lys Gly Lys Leu Gln Tyr Glu Leu Gln Tyr 
145                 150                 155                 160 


Arg Asn Arg Gly Asp Pro Trp Ala Val Ser Pro Arg Arg Lys Leu Ile 
                165                 170                 175     


Ser Val Asp Ser Arg Ser Val Ser Leu Leu Pro Leu Glu Phe Arg Lys 
            180                 185                 190         


Asp Ser Ser Tyr Glu Leu Gln Val Arg Ala Gly Pro Met Pro Gly Ser 
        195                 200                 205             


Ser Tyr Gln Gly Thr Trp Ser Glu Trp Ser Asp Pro Val Ile Phe Gln 
    210                 215                 220                 


Thr Gln Ser Glu Glu Leu Lys Glu Gly Trp Asn Pro His Leu Leu Leu 
225                 230                 235                 240 


Leu Leu Leu Leu Val Ile Val Phe Ile Pro Ala Phe Trp Ser Leu Lys 
                245                 250                 255     


Thr His Pro Leu Trp Arg Leu Trp Lys Lys Ile Trp Ala Val Pro Ser 
            260                 265                 270         


Pro Glu Arg Phe Phe Met Pro Leu Tyr Lys Gly Cys Ser Gly Asp Phe 
        275                 280                 285             


Lys Lys Trp Val Gly Ala Pro Phe Thr Gly Ser Ser Leu Glu Leu Gly 
    290                 295                 300                 


Pro Trp Ser Pro Glu Val Pro Ser Thr Leu Glu Val Tyr Ser Cys His 
305                 310                 315                 320 


Pro Pro Arg Ser Pro Ala Lys Arg Leu Gln Leu Thr Glu Leu Gln Glu 
                325                 330                 335     


Pro Ala Glu Leu Val Glu Ser Asp Gly Val Pro Lys Pro Ser Phe Trp 
            340                 345                 350         


Pro Thr Ala Gln Asn Ser Gly Gly Ser Ala Tyr Ser Glu Glu Arg Asp 
        355                 360                 365             


Arg Pro Tyr Gly Leu Val Ser Ile Asp Thr Val Thr Val Leu Asp Ala 
    370                 375                 380                 


Glu Gly Pro Cys Thr Trp Pro Cys Ser Cys Glu Asp Asp Gly Tyr Pro 
385                 390                 395                 400 


Ala Leu Asp Leu Asp Ala Gly Leu Glu Pro Ser Pro Gly Leu Glu Asp 
                405                 410                 415     


Pro Leu Leu Asp Ala Gly Thr Thr Val Leu Ser Cys Gly Cys Val Ser 
            420                 425                 430         


Ala Gly Ser Pro Gly Leu Gly Gly Pro Leu Gly Ser Leu Leu Asp Arg 
        435                 440                 445             


Leu Lys Pro Pro Leu Ala Asp Gly Glu Asp Trp Ala Gly Gly Leu Pro 
    450                 455                 460                 


Trp Gly Gly Arg Ser Pro Gly Gly Val Ser Glu Ser Glu Ala Gly Ser 
465                 470                 475                 480 


Pro Leu Ala Gly Leu Asp Met Asp Thr Phe Asp Ser Gly Phe Val Gly 
                485                 490                 495     


Ser Asp Cys Ser Ser Pro Val Glu Cys Asp Phe Thr Ser Pro Gly Asp 
            500                 505                 510         


Glu Gly Pro Pro Arg Ser Tyr Leu Arg Gln Trp Val Val Ile Pro Pro 
        515                 520                 525             


Pro Leu Ser Ser Pro Gly Pro Gln Ala Ser 
    530                 535             


<210>  13
<211>  538
<212>  PRT
<213>  Homo sapiens

<400>  13

Met Pro Arg Gly Trp Ala Ala Pro Leu Leu Leu Leu Leu Leu Gln Gly 
1               5                   10                  15      


Gly Trp Gly Cys Pro Asp Leu Val Cys Tyr Thr Asp Tyr Leu Gln Thr 
            20                  25                  30          


Val Ile Cys Ile Leu Glu Met Trp Asn Leu His Pro Ser Thr Leu Thr 
        35                  40                  45              


Leu Thr Trp Gln Asp Gln Tyr Glu Glu Leu Lys Asp Glu Ala Thr Ser 
    50                  55                  60                  


Cys Ser Leu His Arg Ser Ala His Asn Ala Thr His Ala Thr Tyr Thr 
65                  70                  75                  80  


Cys His Met Asp Val Phe His Phe Met Ala Asp Asp Ile Phe Ser Val 
                85                  90                  95      


Asn Ile Thr Asp Gln Ser Gly Asn Tyr Ser Gln Glu Cys Gly Ser Phe 
            100                 105                 110         


Leu Leu Ala Glu Ser Ile Lys Pro Ala Pro Pro Phe Asn Val Thr Val 
        115                 120                 125             


Thr Phe Ser Gly Gln Tyr Asn Ile Ser Trp Arg Ser Asp Tyr Glu Asp 
    130                 135                 140                 


Pro Ala Phe Tyr Met Leu Lys Gly Lys Leu Gln Tyr Glu Leu Gln Tyr 
145                 150                 155                 160 


Arg Asn Arg Gly Asp Pro Trp Ala Val Ser Pro Arg Arg Lys Leu Ile 
                165                 170                 175     


Ser Val Asp Ser Arg Ser Val Ser Leu Leu Pro Leu Glu Phe Arg Lys 
            180                 185                 190         


Asp Ser Ser Tyr Glu Leu Gln Val Arg Ala Gly Pro Met Pro Gly Ser 
        195                 200                 205             


Ser Tyr Gln Gly Thr Trp Ser Glu Trp Ser Asp Pro Val Ile Phe Gln 
    210                 215                 220                 


Thr Gln Ser Glu Glu Leu Lys Glu Gly Trp Asn Pro His Leu Leu Leu 
225                 230                 235                 240 


Leu Leu Leu Leu Val Ile Val Phe Ile Pro Ala Phe Trp Ser Leu Lys 
                245                 250                 255     


Thr His Pro Leu Trp Arg Leu Trp Lys Lys Ile Trp Ala Val Pro Ser 
            260                 265                 270         


Pro Glu Arg Phe Phe Met Pro Leu Tyr Lys Gly Cys Ser Gly Asp Phe 
        275                 280                 285             


Lys Lys Trp Val Gly Ala Pro Phe Thr Gly Ser Ser Leu Glu Leu Gly 
    290                 295                 300                 


Pro Trp Ser Pro Glu Val Pro Ser Thr Leu Glu Val Tyr Ser Cys His 
305                 310                 315                 320 


Pro Pro Arg Ser Pro Ala Lys Arg Leu Gln Leu Thr Glu Leu Gln Glu 
                325                 330                 335     


Pro Ala Glu Leu Val Glu Ser Asp Gly Val Pro Lys Pro Ser Phe Trp 
            340                 345                 350         


Pro Thr Ala Gln Asn Ser Gly Gly Ser Ala Tyr Ser Glu Glu Arg Asp 
        355                 360                 365             


Arg Pro Tyr Gly Leu Val Ser Ile Asp Thr Val Thr Val Leu Asp Ala 
    370                 375                 380                 


Glu Gly Pro Cys Thr Trp Pro Cys Ser Cys Glu Asp Asp Gly Tyr Pro 
385                 390                 395                 400 


Ala Leu Asp Leu Asp Ala Gly Leu Glu Pro Ser Pro Gly Leu Glu Asp 
                405                 410                 415     


Pro Leu Leu Asp Ala Gly Thr Thr Val Leu Ser Cys Gly Cys Val Ser 
            420                 425                 430         


Ala Gly Ser Pro Gly Leu Gly Gly Pro Leu Gly Ser Leu Leu Asp Arg 
        435                 440                 445             


Leu Lys Pro Pro Leu Ala Asp Gly Glu Asp Trp Ala Gly Gly Leu Pro 
    450                 455                 460                 


Trp Gly Gly Arg Ser Pro Gly Gly Val Ser Glu Ser Glu Ala Gly Ser 
465                 470                 475                 480 


Pro Leu Ala Gly Leu Asp Met Asp Thr Phe Asp Ser Gly Phe Val Gly 
                485                 490                 495     


Ser Asp Cys Ser Ser Pro Val Glu Cys Asp Phe Thr Ser Pro Gly Asp 
            500                 505                 510         


Glu Gly Pro Pro Arg Ser Tyr Leu Arg Gln Trp Val Val Ile Pro Pro 
        515                 520                 525             


Pro Leu Ser Ser Pro Gly Pro Gln Ala Ser 
    530                 535             


<210>  14
<211>  538
<212>  PRT
<213>  Homo sapiens

<400>  14

Met Pro Arg Gly Trp Ala Ala Pro Leu Leu Leu Leu Leu Leu Gln Gly 
1               5                   10                  15      


Gly Trp Gly Cys Pro Asp Leu Val Cys Tyr Thr Asp Tyr Leu Gln Thr 
            20                  25                  30          


Val Ile Cys Ile Leu Glu Met Trp Asn Leu His Pro Ser Thr Leu Thr 
        35                  40                  45              


Leu Thr Trp Gln Asp Gln Tyr Glu Glu Leu Lys Asp Glu Ala Thr Ser 
    50                  55                  60                  


Cys Ser Leu His Arg Ser Ala His Asn Ala Thr His Ala Thr Tyr Thr 
65                  70                  75                  80  


Cys His Met Asp Val Phe His Phe Met Ala Asp Asp Ile Phe Ser Val 
                85                  90                  95      


Asn Ile Thr Asp Gln Ser Gly Asn Tyr Ser Gln Glu Cys Gly Ser Phe 
            100                 105                 110         


Leu Leu Ala Glu Ser Ile Lys Pro Ala Pro Pro Phe Asn Val Thr Val 
        115                 120                 125             


Thr Phe Ser Gly Gln Tyr Asn Ile Ser Trp Arg Ser Asp Tyr Glu Asp 
    130                 135                 140                 


Pro Ala Phe Tyr Met Leu Lys Gly Lys Leu Gln Tyr Glu Leu Gln Tyr 
145                 150                 155                 160 


Arg Asn Arg Gly Asp Pro Trp Ala Val Ser Pro Arg Arg Lys Leu Ile 
                165                 170                 175     


Ser Val Asp Ser Arg Ser Val Ser Leu Leu Pro Leu Glu Phe Arg Lys 
            180                 185                 190         


Asp Ser Ser Tyr Glu Leu Gln Val Arg Ala Gly Pro Met Pro Gly Ser 
        195                 200                 205             


Ser Tyr Gln Gly Thr Trp Ser Glu Trp Ser Asp Pro Val Ile Phe Gln 
    210                 215                 220                 


Thr Gln Ser Glu Glu Leu Lys Glu Gly Trp Asn Pro His Leu Leu Leu 
225                 230                 235                 240 


Leu Leu Leu Leu Val Ile Val Phe Ile Pro Ala Phe Trp Ser Leu Lys 
                245                 250                 255     


Thr His Pro Leu Trp Arg Leu Trp Lys Lys Ile Trp Ala Val Pro Ser 
            260                 265                 270         


Pro Glu Arg Phe Phe Met Pro Leu Tyr Lys Gly Cys Ser Gly Asp Phe 
        275                 280                 285             


Lys Lys Trp Val Gly Ala Pro Phe Thr Gly Ser Ser Leu Glu Leu Gly 
    290                 295                 300                 


Pro Trp Ser Pro Glu Val Pro Ser Thr Leu Glu Val Tyr Ser Cys His 
305                 310                 315                 320 


Pro Pro Arg Ser Pro Ala Lys Arg Leu Gln Leu Thr Glu Leu Gln Glu 
                325                 330                 335     


Pro Ala Glu Leu Val Glu Ser Asp Gly Val Pro Lys Pro Ser Phe Trp 
            340                 345                 350         


Pro Thr Ala Gln Asn Ser Gly Gly Ser Ala Tyr Ser Glu Glu Arg Asp 
        355                 360                 365             


Arg Pro Tyr Gly Leu Val Ser Ile Asp Thr Val Thr Val Leu Asp Ala 
    370                 375                 380                 


Glu Gly Pro Cys Thr Trp Pro Cys Ser Cys Glu Asp Asp Gly Tyr Pro 
385                 390                 395                 400 


Ala Leu Asp Leu Asp Ala Gly Leu Glu Pro Ser Pro Gly Leu Glu Asp 
                405                 410                 415     


Pro Leu Leu Asp Ala Gly Thr Thr Val Leu Ser Cys Gly Cys Val Ser 
            420                 425                 430         


Ala Gly Ser Pro Gly Leu Gly Gly Pro Leu Gly Ser Leu Leu Asp Arg 
        435                 440                 445             


Leu Lys Pro Pro Leu Ala Asp Gly Glu Asp Trp Ala Gly Gly Leu Pro 
    450                 455                 460                 


Trp Gly Gly Arg Ser Pro Gly Gly Val Ser Glu Ser Glu Ala Gly Ser 
465                 470                 475                 480 


Pro Leu Ala Gly Leu Asp Met Asp Thr Phe Asp Ser Gly Phe Val Gly 
                485                 490                 495     


Ser Asp Cys Ser Ser Pro Val Glu Cys Asp Phe Thr Ser Pro Gly Asp 
            500                 505                 510         


Glu Gly Pro Pro Arg Ser Tyr Leu Arg Gln Trp Val Val Ile Pro Pro 
        515                 520                 525             


Pro Leu Ser Ser Pro Gly Pro Gln Ala Ser 
    530                 535             


<210>  15
<211>  467
<212>  PRT
<213>  Homo sapiens

<400>  15

Met Arg Pro Gln Glu Leu Pro Arg Leu Ala Phe Pro Leu Leu Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Leu Pro Pro Pro Pro Cys Pro Ala His Ser Ala Thr 
            20                  25                  30          


Arg Phe Asp Pro Thr Trp Glu Ser Leu Asp Ala Arg Gln Leu Pro Ala 
        35                  40                  45              


Trp Phe Asp Gln Ala Lys Phe Gly Ile Phe Ile His Trp Gly Val Phe 
    50                  55                  60                  


Ser Val Pro Ser Phe Gly Ser Glu Trp Phe Trp Trp Tyr Trp Gln Lys 
65                  70                  75                  80  


Glu Lys Ile Pro Lys Tyr Val Glu Phe Met Lys Asp Asn Tyr Pro Pro 
                85                  90                  95      


Ser Phe Lys Tyr Glu Asp Phe Gly Pro Leu Phe Thr Ala Lys Phe Phe 
            100                 105                 110         


Asn Ala Asn Gln Trp Ala Asp Ile Phe Gln Ala Ser Gly Ala Lys Tyr 
        115                 120                 125             


Ile Val Leu Thr Ser Lys His His Glu Gly Phe Thr Leu Trp Gly Ser 
    130                 135                 140                 


Glu Tyr Ser Trp Asn Trp Asn Ala Ile Asp Glu Gly Pro Lys Arg Asp 
145                 150                 155                 160 


Ile Val Lys Glu Leu Glu Val Ala Ile Arg Asn Arg Thr Asp Leu Arg 
                165                 170                 175     


Phe Gly Leu Tyr Tyr Ser Leu Phe Glu Trp Phe His Pro Leu Phe Leu 
            180                 185                 190         


Glu Asp Glu Ser Ser Ser Phe His Lys Arg Gln Phe Pro Val Ser Lys 
        195                 200                 205             


Thr Leu Pro Glu Leu Tyr Glu Leu Val Asn Asn Tyr Gln Pro Glu Val 
    210                 215                 220                 


Leu Trp Ser Asp Gly Asp Gly Gly Ala Pro Asp Gln Tyr Trp Asn Ser 
225                 230                 235                 240 


Thr Gly Phe Leu Ala Trp Leu Tyr Asn Glu Ser Pro Val Arg Gly Thr 
                245                 250                 255     


Val Val Thr Asn Asp Arg Trp Gly Ala Gly Ser Ile Cys Lys His Gly 
            260                 265                 270         


Gly Phe Tyr Thr Cys Ser Asp Arg Tyr Asn Pro Gly His Leu Leu Pro 
        275                 280                 285             


His Lys Trp Glu Asn Cys Met Thr Ile Asp Lys Leu Ser Trp Gly Tyr 
    290                 295                 300                 


Arg Arg Glu Ala Gly Ile Ser Asp Tyr Leu Thr Ile Glu Glu Leu Val 
305                 310                 315                 320 


Lys Gln Leu Val Glu Thr Val Ser Cys Gly Gly Asn Leu Leu Met Asn 
                325                 330                 335     


Ile Gly Pro Thr Leu Asp Gly Thr Ile Ser Val Val Phe Glu Glu Arg 
            340                 345                 350         


Leu Arg Gln Met Gly Ser Trp Leu Lys Val Asn Gly Glu Ala Ile Tyr 
        355                 360                 365             


Glu Thr His Thr Trp Arg Ser Gln Asn Asp Thr Val Thr Pro Asp Val 
    370                 375                 380                 


Trp Tyr Thr Ser Lys Pro Lys Glu Lys Leu Val Tyr Ala Ile Phe Leu 
385                 390                 395                 400 


Lys Trp Pro Thr Ser Gly Gln Leu Phe Leu Gly His Pro Lys Ala Ile 
                405                 410                 415     


Leu Gly Ala Thr Glu Val Lys Leu Leu Gly His Gly Gln Pro Leu Asn 
            420                 425                 430         


Trp Ile Ser Leu Glu Gln Asn Gly Ile Met Val Glu Leu Pro Gln Leu 
        435                 440                 445             


Thr Ile His Gln Met Pro Cys Lys Trp Gly Trp Ala Leu Ala Leu Thr 
    450                 455                 460                 


Asn Val Ile 
465         


<210>  16
<211>  109
<212>  PRT
<213>  Homo sapiens

<400>  16

Gln Leu Val Glu Thr Val Ser Cys Gly Gly Asn Leu Leu Met Asn Ile 
1               5                   10                  15      


Gly Pro Thr Leu Asp Gly Thr Ile Ser Val Val Phe Glu Glu Arg Leu 
            20                  25                  30          


Arg Gln Met Gly Ser Trp Leu Lys Val Asn Gly Glu Ala Ile Tyr Glu 
        35                  40                  45              


Thr His Thr Trp Arg Ser Gln Asn Asp Thr Val Thr Pro Asp Val Trp 
    50                  55                  60                  


Tyr Thr Ser Lys Pro Lys Glu Lys Leu Val Tyr Ala Ile Phe Leu Lys 
65                  70                  75                  80  


Trp Pro Thr Ser Gly Gln Leu Phe Leu Gly His Pro Lys Ala Ile Leu 
                85                  90                  95      


Gly Ala Thr Glu Val Arg Gly Asn Phe Thr Leu Phe Leu 
            100                 105                 


<210>  17
<211>  350
<212>  PRT
<213>  Homo sapiens

<400>  17

Met Ser Gly His Lys Cys Ser Tyr Pro Trp Asp Leu Gln Asp Arg Tyr 
1               5                   10                  15      


Ala Gln Asp Lys Ser Val Val Asn Lys Met Gln Gln Lys Tyr Trp Glu 
            20                  25                  30          


Thr Lys Gln Ala Phe Ile Lys Ala Thr Gly Lys Lys Glu Asp Glu His 
        35                  40                  45              


Val Val Ala Ser Asp Ala Asp Leu Asp Ala Lys Leu Glu Leu Phe His 
    50                  55                  60                  


Ser Ile Gln Arg Thr Cys Leu Asp Leu Ser Lys Ala Ile Val Leu Tyr 
65                  70                  75                  80  


Gln Lys Arg Ile Cys Phe Leu Ser Gln Glu Glu Asn Glu Leu Gly Lys 
                85                  90                  95      


Phe Leu Arg Ser Gln Gly Phe Gln Asp Lys Thr Arg Ala Gly Lys Met 
            100                 105                 110         


Met Gln Ala Thr Gly Lys Ala Leu Cys Phe Ser Ser Gln Gln Arg Leu 
        115                 120                 125             


Ala Leu Arg Asn Pro Leu Cys Arg Phe His Gln Glu Val Glu Thr Phe 
    130                 135                 140                 


Arg His Arg Ala Ile Ser Asp Thr Trp Leu Thr Val Asn Arg Met Glu 
145                 150                 155                 160 


Gln Cys Arg Thr Glu Tyr Arg Gly Ala Leu Leu Trp Met Lys Asp Val 
                165                 170                 175     


Ser Gln Glu Leu Asp Pro Asp Leu Tyr Lys Gln Met Glu Lys Phe Arg 
            180                 185                 190         


Lys Val Gln Thr Gln Val Arg Leu Ala Lys Lys Asn Phe Asp Lys Leu 
        195                 200                 205             


Lys Met Asp Val Cys Gln Lys Val Asp Leu Leu Gly Ala Ser Arg Cys 
    210                 215                 220                 


Asn Leu Leu Ser His Met Leu Ala Thr Tyr Gln Thr Thr Leu Leu His 
225                 230                 235                 240 


Phe Trp Glu Lys Thr Ser His Thr Met Ala Ala Ile His Glu Ser Phe 
                245                 250                 255     


Lys Gly Tyr Gln Pro Tyr Glu Phe Thr Thr Leu Lys Val Trp Lys Leu 
            260                 265                 270         


Glu Gly Pro Leu Glu Asn Leu Glu Lys Ser Lys Val Leu Phe Ile Ser 
        275                 280                 285             


Gln Ala Lys Ser Ile Ala Glu Ser Ile Ile Ile Pro Gly Leu Arg Met 
    290                 295                 300                 


Leu Lys Arg Glu Leu Cys Pro Gln Gln Ser Leu Phe Leu Ser Phe Phe 
305                 310                 315                 320 


Leu Ser Phe Phe Phe Phe Phe Phe Phe Phe Thr Ala Ser Gly Phe Asn 
                325                 330                 335     


Thr Met Arg Ile Tyr Cys Asn Pro Lys Ala Arg Ile Glu Pro 
            340                 345                 350 


<210>  18
<211>  443
<212>  PRT
<213>  Homo sapiens

<400>  18

Met Ala Ala Ser Pro His Thr Leu Ser Ser Arg Leu Leu Thr Gly Cys 
1               5                   10                  15      


Val Gly Gly Ser Val Trp Tyr Leu Glu Arg Arg Thr Ile Gln Asp Ser 
            20                  25                  30          


Pro His Lys Phe Leu His Leu Leu Arg Asn Val Asn Lys Gln Trp Ile 
        35                  40                  45              


Thr Phe Gln His Phe Ser Phe Leu Lys Arg Met Tyr Val Thr Gln Leu 
    50                  55                  60                  


Asn Arg Ser His Asn Gln Gln Val Arg Pro Lys Pro Glu Pro Val Ala 
65                  70                  75                  80  


Ser Pro Phe Leu Glu Lys Thr Ser Ser Gly Gln Ala Lys Ala Glu Ile 
                85                  90                  95      


Tyr Glu Met Arg Pro Leu Ser Pro Pro Ser Leu Ser Leu Ser Arg Lys 
            100                 105                 110         


Pro Asn Glu Lys Glu Leu Ile Glu Leu Glu Pro Asp Ser Val Ile Glu 
        115                 120                 125             


Asp Ser Ile Asp Val Gly Lys Glu Thr Lys Glu Glu Lys Arg Trp Lys 
    130                 135                 140                 


Glu Met Lys Leu Gln Val Tyr Asp Leu Pro Gly Ile Leu Ala Arg Leu 
145                 150                 155                 160 


Ser Lys Ile Lys Leu Thr Ala Leu Val Val Ser Thr Thr Ala Ala Gly 
                165                 170                 175     


Phe Ala Leu Ala Pro Gly Pro Phe Asp Trp Pro Cys Phe Leu Leu Thr 
            180                 185                 190         


Ser Val Gly Thr Gly Leu Ala Ser Cys Ala Ala Asn Ser Ile Asn Gln 
        195                 200                 205             


Phe Phe Glu Val Pro Phe Asp Ser Asn Met Asn Arg Thr Lys Asn Arg 
    210                 215                 220                 


Pro Leu Val Arg Gly Gln Ile Ser Pro Leu Leu Ala Val Ser Phe Ala 
225                 230                 235                 240 


Thr Cys Cys Ala Val Pro Gly Val Ala Ile Leu Thr Leu Gly Val Asn 
                245                 250                 255     


Pro Leu Thr Gly Ala Leu Gly Leu Phe Asn Ile Phe Leu Tyr Thr Cys 
            260                 265                 270         


Cys Tyr Thr Pro Leu Lys Arg Ile Ser Ile Ala Asn Thr Trp Val Gly 
        275                 280                 285             


Ala Val Val Gly Ala Ile Pro Pro Val Met Gly Trp Thr Ala Ala Thr 
    290                 295                 300                 


Gly Ser Leu Asp Ala Gly Ala Phe Leu Leu Gly Gly Ile Leu Tyr Ser 
305                 310                 315                 320 


Trp Gln Phe Pro His Phe Asn Ala Leu Ser Trp Gly Leu Arg Glu Asp 
                325                 330                 335     


Tyr Ser Arg Gly Gly Tyr Cys Met Met Ser Val Thr His Pro Gly Leu 
            340                 345                 350         


Cys Arg Arg Val Ala Leu Arg His Cys Leu Ala Leu Leu Val Leu Ser 
        355                 360                 365             


Ala Ala Ala Pro Val Leu Asp Ile Thr Thr Trp Thr Phe Pro Ile Met 
    370                 375                 380                 


Ala Leu Pro Ile Asn Ala Tyr Ile Ser Tyr Leu Gly Phe Arg Phe Tyr 
385                 390                 395                 400 


Val Asp Ala Asp Arg Arg Ser Ser Arg Arg Leu Phe Phe Cys Ser Leu 
                405                 410                 415     


Trp His Leu Pro Leu Leu Leu Leu Leu Met Leu Thr Cys Lys Arg Pro 
            420                 425                 430         


Ser Gly Gly Gly Asp Ala Gly Pro Pro Pro Ser 
        435                 440             


<210>  19
<211>  168
<212>  PRT
<213>  Homo sapiens

<400>  19

Met Cys Phe Pro Lys Val Leu Ser Asp Asp Met Lys Lys Leu Lys Ala 
1               5                   10                  15      


Arg Met Val Met Ser Ser Leu Ala Glu Leu Glu Asp Asp Phe Lys Glu 
            20                  25                  30          


Gly Tyr Leu Glu Thr Val Ala Ala Tyr Tyr Glu Glu Gln His Pro Glu 
        35                  40                  45              


Leu Thr Pro Leu Leu Glu Lys Glu Arg Asp Gly Leu Arg Cys Arg Gly 
    50                  55                  60                  


Asn Arg Ser Pro Val Pro Asp Val Glu Asp Pro Ala Thr Glu Glu Pro 
65                  70                  75                  80  


Gly Glu Ser Phe Cys Asp Lys Val Met Arg Trp Phe Gln Ala Met Leu 
                85                  90                  95      


Gln Arg Leu Gln Thr Trp Trp His Gly Val Leu Ala Trp Val Lys Glu 
            100                 105                 110         


Lys Val Val Ala Leu Val His Ala Val Gln Ala Leu Trp Lys Gln Phe 
        115                 120                 125             


Gln Ser Phe Cys Cys Ser Leu Ser Glu Leu Phe Met Ser Ser Phe Gln 
    130                 135                 140                 


Ser Tyr Gly Ala Pro Arg Gly Asp Lys Glu Glu Leu Thr Pro Gln Lys 
145                 150                 155                 160 


Cys Ser Glu Pro Gln Ser Ser Lys 
                165             


<210>  20
<211>  234
<212>  PRT
<213>  Homo sapiens

<400>  20

Met Cys Phe Pro Lys Val Leu Ser Asp Asp Met Lys Lys Leu Lys Ala 
1               5                   10                  15      


Arg Met Val Met Leu Leu Pro Thr Ser Ala Gln Gly Leu Gly Ala Trp 
            20                  25                  30          


Val Ser Ala Cys Asp Thr Glu Asp Thr Val Gly His Leu Gly Pro Trp 
        35                  40                  45              


Arg Asp Lys Asp Pro Ala Leu Trp Cys Gln Leu Cys Leu Ser Ser Gln 
    50                  55                  60                  


His Gln Ala Ile Glu Arg Phe Tyr Asp Lys Met Gln Asn Ala Glu Ser 
65                  70                  75                  80  


Gly Arg Gly Gln Val Met Ser Ser Leu Ala Glu Leu Glu Asp Asp Phe 
                85                  90                  95      


Lys Glu Gly Tyr Leu Glu Thr Val Ala Ala Tyr Tyr Glu Glu Gln His 
            100                 105                 110         


Pro Glu Leu Thr Pro Leu Leu Glu Lys Glu Arg Asp Gly Leu Arg Cys 
        115                 120                 125             


Arg Gly Asn Arg Ser Pro Val Pro Asp Val Glu Asp Pro Ala Thr Glu 
    130                 135                 140                 


Glu Pro Gly Glu Ser Phe Cys Asp Lys Val Met Arg Trp Phe Gln Ala 
145                 150                 155                 160 


Met Leu Gln Arg Leu Gln Thr Trp Trp His Gly Val Leu Ala Trp Val 
                165                 170                 175     


Lys Glu Lys Val Val Ala Leu Val His Ala Val Gln Ala Leu Trp Lys 
            180                 185                 190         


Gln Phe Gln Ser Phe Cys Cys Ser Leu Ser Glu Leu Phe Met Ser Ser 
        195                 200                 205             


Phe Gln Ser Tyr Gly Ala Pro Arg Gly Asp Lys Glu Glu Leu Thr Pro 
    210                 215                 220                 


Gln Lys Cys Ser Glu Pro Gln Ser Ser Lys 
225                 230                 


<210>  21
<211>  131
<212>  PRT
<213>  Homo sapiens

<400>  21

Met Cys Phe Pro Lys Val Leu Ser Asp Asp Met Lys Lys Leu Lys Ala 
1               5                   10                  15      


Arg Met Asp Asp Phe Lys Glu Gly Tyr Leu Glu Thr Val Ala Ala Tyr 
            20                  25                  30          


Tyr Glu Glu Gln His Pro Glu Leu Thr Pro Leu Leu Glu Lys Glu Arg 
        35                  40                  45              


Asp Gly Leu Arg Cys Arg Gly Asn Arg Ser Pro Val Pro Asp Val Glu 
    50                  55                  60                  


Asp Pro Ala Thr Glu Glu Pro Gly Glu Ser Phe Cys Asp Lys Val Met 
65                  70                  75                  80  


Arg Trp Phe Gln Ala Met Leu Gln Arg Leu Gln Thr Trp Trp His Gly 
                85                  90                  95      


Val Leu Ala Trp Val Lys Glu Lys Val Val Ala Leu Val His Ala Val 
            100                 105                 110         


Gln Ala Leu Trp Lys Gln Phe Gln Ser Phe Cys Cys Ser Leu Ser Glu 
        115                 120                 125             


Leu Phe Met 
    130     


<210>  22
<211>  442
<212>  PRT
<213>  Homo sapiens

<400>  22

Met Cys Phe Pro Lys Val Leu Ser Asp Asp Met Lys Lys Leu Lys Ala 
1               5                   10                  15      


Arg Met Val Met Leu Leu Pro Thr Ser Ala Gln Gly Leu Gly Ala Trp 
            20                  25                  30          


Val Ser Ala Cys Asp Thr Glu Asp Thr Val Gly His Leu Gly Pro Trp 
        35                  40                  45              


Arg Asp Lys Asp Pro Ala Leu Trp Cys Gln Leu Cys Leu Ser Ser Gln 
    50                  55                  60                  


His Gln Ala Ile Glu Arg Phe Tyr Asp Lys Met Gln Asn Ala Glu Ser 
65                  70                  75                  80  


Gly Arg Gly Gln Val Met Ser Ser Leu Ala Glu Leu Glu Asp Asp Phe 
                85                  90                  95      


Lys Glu Gly Tyr Leu Glu Thr Val Ala Ala Tyr Tyr Glu Glu Gln His 
            100                 105                 110         


Pro Glu Leu Thr Pro Leu Leu Glu Lys Glu Arg Asp Gly Leu Arg Cys 
        115                 120                 125             


Arg Gly Asn Arg Ser Pro Val Pro Asp Val Glu Asp Pro Ala Thr Glu 
    130                 135                 140                 


Glu Pro Gly Glu Ser Phe Cys Asp Lys Val Met Arg Trp Phe Gln Ala 
145                 150                 155                 160 


Met Leu Gln Arg Leu Gln Thr Trp Trp His Gly Val Leu Ala Trp Val 
                165                 170                 175     


Lys Glu Lys Val Val Ala Leu Val His Ala Val Gln Ala Leu Trp Lys 
            180                 185                 190         


Gln Phe Gln Ser Phe Cys Cys Ser Leu Ser Glu Leu Phe Met Ser Ser 
        195                 200                 205             


Phe Gln Ser Tyr Gly Ala Thr Arg Gly Ala Arg Arg Ser Met Cys Phe 
    210                 215                 220                 


Pro Lys Val Leu Ser Asp Asp Met Lys Lys Leu Lys Ala Arg Met Val 
225                 230                 235                 240 


Met Leu Leu Pro Thr Ser Ala Gln Gly Leu Gly Ala Trp Val Ser Ala 
                245                 250                 255     


Cys Asp Thr Glu Asp Thr Val Gly His Leu Gly Pro Trp Arg Asp Lys 
            260                 265                 270         


Asp Pro Ala Leu Trp Cys Gln Leu Cys Leu Ser Ser Gln His Gln Ala 
        275                 280                 285             


Ile Glu Arg Phe Tyr Asp Lys Met Gln Asn Ala Glu Ser Gly Arg Gly 
    290                 295                 300                 


Gln Val Met Ser Ser Leu Ala Glu Leu Glu Asp Asp Phe Lys Glu Gly 
305                 310                 315                 320 


Tyr Leu Glu Thr Val Ala Ala Tyr Tyr Glu Glu Gln His Pro Glu Leu 
                325                 330                 335     


Thr Pro Leu Leu Glu Lys Glu Arg Asp Gly Leu Arg Cys Arg Gly Asn 
            340                 345                 350         


Arg Ser Pro Val Pro Asp Val Glu Asp Pro Ala Thr Glu Glu Pro Gly 
        355                 360                 365             


Glu Ser Phe Cys Asp Lys Val Met Arg Trp Phe Gln Ala Met Leu Gln 
    370                 375                 380                 


Arg Leu Gln Thr Trp Trp His Gly Val Leu Ala Trp Val Lys Glu Lys 
385                 390                 395                 400 


Val Val Ala Leu Val His Ala Val Gln Ala Leu Trp Lys Gln Phe Gln 
                405                 410                 415     


Ser Phe Cys Cys Ser Leu Ser Glu Leu Phe Met Ser Ser Phe Gln Ser 
            420                 425                 430         


Tyr Gly Ala Thr Arg Gly Ala Arg Arg Ser 
        435                 440         


<210>  23
<211>  168
<212>  PRT
<213>  Homo sapiens

<400>  23

Met Cys Phe Pro Lys Val Leu Ser Asp Asp Met Lys Lys Leu Lys Ala 
1               5                   10                  15      


Arg Met Val Met Ser Ser Leu Ala Glu Leu Glu Asp Asp Phe Lys Glu 
            20                  25                  30          


Gly Tyr Leu Glu Thr Val Ala Ala Tyr Tyr Glu Glu Gln His Pro Glu 
        35                  40                  45              


Leu Thr Pro Leu Leu Glu Lys Glu Arg Asp Gly Leu Arg Cys Arg Gly 
    50                  55                  60                  


Asn Arg Ser Pro Val Pro Asp Val Glu Asp Pro Ala Thr Glu Glu Pro 
65                  70                  75                  80  


Gly Glu Ser Phe Cys Asp Lys Val Met Arg Trp Phe Gln Ala Met Leu 
                85                  90                  95      


Gln Arg Leu Gln Thr Trp Trp His Gly Val Leu Ala Trp Val Lys Glu 
            100                 105                 110         


Lys Val Val Ala Leu Val His Ala Val Gln Ala Leu Trp Lys Gln Phe 
        115                 120                 125             


Gln Ser Phe Cys Cys Ser Leu Ser Glu Leu Phe Met Ser Ser Phe Gln 
    130                 135                 140                 


Ser Tyr Gly Ala Pro Arg Gly Asp Lys Glu Glu Leu Thr Pro Gln Lys 
145                 150                 155                 160 


Cys Ser Glu Pro Gln Ser Ser Lys 
                165             


<210>  24
<211>  234
<212>  PRT
<213>  Homo sapiens

<400>  24

Met Cys Phe Pro Lys Val Leu Ser Asp Asp Met Lys Lys Leu Lys Ala 
1               5                   10                  15      


Arg Met Val Met Leu Leu Pro Thr Ser Ala Gln Gly Leu Gly Ala Trp 
            20                  25                  30          


Val Ser Ala Cys Asp Thr Glu Asp Thr Val Gly His Leu Gly Pro Trp 
        35                  40                  45              


Arg Asp Lys Asp Pro Ala Leu Trp Cys Gln Leu Cys Leu Ser Ser Gln 
    50                  55                  60                  


His Gln Ala Ile Glu Arg Phe Tyr Asp Lys Met Gln Asn Ala Glu Ser 
65                  70                  75                  80  


Gly Arg Gly Gln Val Met Ser Ser Leu Ala Glu Leu Glu Asp Asp Phe 
                85                  90                  95      


Lys Glu Gly Tyr Leu Glu Thr Val Ala Ala Tyr Tyr Glu Glu Gln His 
            100                 105                 110         


Pro Glu Leu Thr Pro Leu Leu Glu Lys Glu Arg Asp Gly Leu Arg Cys 
        115                 120                 125             


Arg Gly Asn Arg Ser Pro Val Pro Asp Val Glu Asp Pro Ala Thr Glu 
    130                 135                 140                 


Glu Pro Gly Glu Ser Phe Cys Asp Lys Val Met Arg Trp Phe Gln Ala 
145                 150                 155                 160 


Met Leu Gln Arg Leu Gln Thr Trp Trp His Gly Val Leu Ala Trp Val 
                165                 170                 175     


Lys Glu Lys Val Val Ala Leu Val His Ala Val Gln Ala Leu Trp Lys 
            180                 185                 190         


Gln Phe Gln Ser Phe Cys Cys Ser Leu Ser Glu Leu Phe Met Ser Ser 
        195                 200                 205             


Phe Gln Ser Tyr Gly Ala Pro Arg Gly Asp Lys Glu Glu Leu Thr Pro 
    210                 215                 220                 


Gln Lys Cys Ser Glu Pro Gln Ser Ser Lys 
225                 230                 


<210>  25
<211>  148
<212>  PRT
<213>  Homo sapiens

<400>  25

Met Cys Phe Pro Lys Val Leu Ser Asp Asp Met Lys Lys Leu Lys Ala 
1               5                   10                  15      


Arg Met Val Met Ser Ser Leu Ala Glu Leu Glu Glu Leu Thr Pro Leu 
            20                  25                  30          


Leu Glu Lys Glu Arg Asp Gly Leu Arg Cys Arg Gly Asn Arg Ser Pro 
        35                  40                  45              


Val Pro Asp Val Glu Asp Pro Ala Thr Glu Glu Pro Gly Glu Ser Phe 
    50                  55                  60                  


Cys Asp Lys Val Met Arg Trp Phe Gln Ala Met Leu Gln Arg Leu Gln 
65                  70                  75                  80  


Thr Trp Trp His Gly Val Leu Ala Trp Val Lys Glu Lys Val Val Ala 
                85                  90                  95      


Leu Val His Ala Val Gln Ala Leu Trp Lys Gln Phe Gln Ser Phe Cys 
            100                 105                 110         


Cys Ser Leu Ser Glu Leu Phe Met Ser Ser Phe Gln Ser Tyr Gly Ala 
        115                 120                 125             


Pro Arg Gly Asp Lys Glu Glu Leu Thr Pro Gln Lys Cys Ser Glu Pro 
    130                 135                 140                 


Gln Ser Ser Lys 
145             


<210>  26
<211>  234
<212>  PRT
<213>  Homo sapiens

<400>  26

Met Cys Phe Pro Lys Val Leu Ser Asp Asp Met Lys Lys Leu Lys Ala 
1               5                   10                  15      


Arg Met Val Met Leu Leu Pro Thr Ser Ala Gln Gly Leu Gly Ala Trp 
            20                  25                  30          


Val Ser Ala Cys Asp Thr Glu Asp Thr Val Gly His Leu Gly Pro Trp 
        35                  40                  45              


Arg Asp Lys Asp Pro Ala Leu Trp Cys Gln Leu Cys Leu Ser Ser Gln 
    50                  55                  60                  


His Gln Ala Ile Glu Arg Phe Tyr Asp Lys Met Gln Asn Ala Glu Ser 
65                  70                  75                  80  


Gly Arg Gly Gln Val Met Ser Ser Leu Ala Glu Leu Glu Asp Asp Phe 
                85                  90                  95      


Lys Glu Gly Tyr Leu Glu Thr Val Ala Ala Tyr Tyr Glu Glu Gln His 
            100                 105                 110         


Pro Glu Leu Thr Pro Leu Leu Glu Lys Glu Arg Asp Gly Leu Arg Cys 
        115                 120                 125             


Arg Gly Asn Arg Ser Pro Val Pro Asp Val Glu Asp Pro Ala Thr Glu 
    130                 135                 140                 


Glu Pro Gly Glu Ser Phe Cys Asp Lys Val Met Arg Trp Phe Gln Ala 
145                 150                 155                 160 


Met Leu Gln Arg Leu Gln Thr Trp Trp His Gly Val Leu Ala Trp Val 
                165                 170                 175     


Lys Glu Lys Val Val Ala Leu Val His Ala Val Gln Ala Leu Trp Lys 
            180                 185                 190         


Gln Phe Gln Ser Phe Cys Cys Ser Leu Ser Glu Leu Phe Met Ser Ser 
        195                 200                 205             


Phe Gln Ser Tyr Gly Ala Pro Arg Gly Asp Lys Glu Glu Leu Thr Pro 
    210                 215                 220                 


Gln Lys Cys Ser Glu Pro Gln Ser Ser Lys 
225                 230                 


<210>  27
<211>  225
<212>  PRT
<213>  Homo sapiens

<400>  27

Met Cys Phe Pro Lys Val Leu Ser Asp Asp Met Lys Lys Leu Lys Ala 
1               5                   10                  15      


Arg Met Val Met Leu Leu Pro Thr Ser Ala Gln Gly Leu Gly Ala Trp 
            20                  25                  30          


Val Ser Ala Cys Asp Thr Glu Asp Thr Val Gly His Leu Gly Pro Trp 
        35                  40                  45              


Arg Asp Lys Asp Pro Ala Leu Trp Cys Gln Leu Cys Leu Ser Ser Gln 
    50                  55                  60                  


His Gln Ala Ile Glu Arg Phe Tyr Asp Lys Met Gln Asn Ala Glu Ser 
65                  70                  75                  80  


Gly Arg Gly Gln Val Met Ser Ser Leu Ala Glu Leu Glu Asp Asp Phe 
                85                  90                  95      


Lys Glu Gly Tyr Leu Glu Thr Val Ala Ala Tyr Tyr Glu Glu Gln His 
            100                 105                 110         


Pro Glu Leu Thr Pro Leu Leu Glu Lys Glu Arg Asp Gly Leu Arg Cys 
        115                 120                 125             


Arg Gly Asn Arg Ser Pro Val Pro Asp Val Glu Asp Pro Ala Thr Glu 
    130                 135                 140                 


Glu Pro Gly Glu Ser Phe Cys Asp Lys Val Met Arg Trp Phe Gln Ala 
145                 150                 155                 160 


Met Leu Gln Arg Leu Gln Thr Trp Trp His Gly Val Leu Ala Trp Val 
                165                 170                 175     


Lys Glu Lys Val Val Ala Leu Val His Ala Val Gln Ala Leu Trp Lys 
            180                 185                 190         


Gln Phe Gln Ser Phe Cys Cys Ser Leu Ser Glu Leu Phe Met Ser Ser 
        195                 200                 205             


Phe Gln Ser Tyr Gly Ala Pro Arg Gly Asp Lys Glu Glu Leu Thr Pro 
    210                 215                 220                 


Gln 
225 


<210>  28
<211>  225
<212>  PRT
<213>  Homo sapiens

<400>  28

Met Cys Phe Pro Lys Val Leu Ser Asp Asp Met Lys Lys Leu Lys Ala 
1               5                   10                  15      


Arg Met Val Met Leu Leu Pro Thr Ser Ala Gln Gly Leu Gly Ala Trp 
            20                  25                  30          


Val Ser Ala Cys Asp Thr Glu Asp Thr Val Gly His Leu Gly Pro Trp 
        35                  40                  45              


Arg Asp Lys Asp Pro Ala Leu Trp Cys Gln Leu Cys Leu Ser Ser Gln 
    50                  55                  60                  


His Gln Ala Ile Glu Arg Phe Tyr Asp Lys Met Gln Asn Ala Glu Ser 
65                  70                  75                  80  


Gly Arg Gly Gln Asp Asp Phe Lys Glu Gly Tyr Leu Glu Thr Val Ala 
                85                  90                  95      


Ala Tyr Tyr Glu Glu Gln His Pro Glu Leu Thr Pro Leu Leu Glu Lys 
            100                 105                 110         


Glu Arg Asp Gly Leu Arg Cys Arg Gly Asn Arg Ser Pro Val Pro Asp 
        115                 120                 125             


Val Glu Asp Pro Ala Thr Glu Glu Pro Gly Glu Ser Phe Cys Asp Lys 
    130                 135                 140                 


Val Met Arg Trp Phe Gln Ala Met Leu Gln Arg Leu Gln Thr Trp Trp 
145                 150                 155                 160 


His Gly Val Leu Ala Trp Val Lys Glu Lys Val Val Ala Leu Val His 
                165                 170                 175     


Ala Val Gln Ala Leu Trp Lys Gln Phe Gln Ser Phe Cys Cys Ser Leu 
            180                 185                 190         


Ser Glu Leu Phe Met Ser Ser Phe Gln Ser Tyr Gly Ala Pro Arg Gly 
        195                 200                 205             


Asp Lys Glu Glu Leu Thr Pro Gln Lys Cys Ser Glu Pro Gln Ser Ser 
    210                 215                 220                 


Lys 
225 


<210>  29
<211>  168
<212>  PRT
<213>  Homo sapiens

<400>  29

Met Cys Phe Pro Lys Val Leu Ser Asp Asp Met Lys Lys Leu Lys Ala 
1               5                   10                  15      


Arg Met Val Met Ser Ser Leu Ala Glu Leu Glu Asp Asp Phe Lys Glu 
            20                  25                  30          


Gly Tyr Leu Glu Thr Val Ala Ala Tyr Tyr Glu Glu Gln His Pro Glu 
        35                  40                  45              


Leu Thr Pro Leu Leu Glu Lys Glu Arg Asp Gly Leu Arg Cys Arg Gly 
    50                  55                  60                  


Asn Arg Ser Pro Val Pro Asp Val Glu Asp Pro Ala Thr Glu Glu Pro 
65                  70                  75                  80  


Gly Glu Ser Phe Cys Asp Lys Val Met Arg Trp Phe Gln Ala Met Leu 
                85                  90                  95      


Gln Arg Leu Gln Thr Trp Trp His Gly Val Leu Ala Trp Val Lys Glu 
            100                 105                 110         


Lys Val Val Ala Leu Val His Ala Val Gln Ala Leu Trp Lys Gln Phe 
        115                 120                 125             


Gln Ser Phe Cys Cys Ser Leu Ser Glu Leu Phe Met Ser Ser Phe Gln 
    130                 135                 140                 


Ser Tyr Gly Ala Pro Arg Gly Asp Lys Glu Glu Leu Thr Pro Gln Lys 
145                 150                 155                 160 


Cys Ser Glu Pro Gln Ser Ser Lys 
                165             


<210>  30
<211>  212
<212>  PRT
<213>  Homo sapiens

<400>  30

Met Cys Phe Pro Lys Gly Leu Gly Ala Trp Val Ser Ala Cys Asp Thr 
1               5                   10                  15      


Glu Asp Thr Val Gly His Leu Gly Pro Trp Arg Asp Lys Asp Pro Ala 
            20                  25                  30          


Leu Trp Cys Gln Leu Cys Leu Ser Ser Gln His Gln Ala Ile Glu Arg 
        35                  40                  45              


Phe Tyr Asp Lys Met Gln Asn Ala Glu Ser Gly Arg Gly Gln Val Met 
    50                  55                  60                  


Ser Ser Leu Ala Glu Leu Glu Asp Asp Phe Lys Glu Gly Tyr Leu Glu 
65                  70                  75                  80  


Thr Val Ala Ala Tyr Tyr Glu Glu Gln His Pro Glu Leu Thr Pro Leu 
                85                  90                  95      


Leu Glu Lys Glu Arg Asp Gly Leu Arg Cys Arg Gly Asn Arg Ser Pro 
            100                 105                 110         


Val Pro Asp Val Glu Asp Pro Ala Thr Glu Glu Pro Gly Glu Ser Phe 
        115                 120                 125             


Cys Asp Lys Val Met Arg Trp Phe Gln Ala Met Leu Gln Arg Leu Gln 
    130                 135                 140                 


Thr Trp Trp His Gly Val Leu Ala Trp Val Lys Glu Lys Val Val Ala 
145                 150                 155                 160 


Leu Val His Ala Val Gln Ala Leu Trp Lys Gln Phe Gln Ser Phe Cys 
                165                 170                 175     


Cys Ser Leu Ser Glu Leu Phe Met Ser Ser Phe Gln Ser Tyr Gly Ala 
            180                 185                 190         


Pro Arg Gly Asp Lys Glu Glu Leu Thr Pro Gln Lys Cys Ser Glu Pro 
        195                 200                 205             


Gln Ser Ser Lys 
    210         


<210>  31
<211>  317
<212>  PRT
<213>  Homo sapiens

<400>  31

Met Gln Glu Gly Glu Leu Ala Ile Ser Pro Ile Ser Pro Val Ala Ala 
1               5                   10                  15      


Met Pro Pro Leu Gly Thr His Val Gln Ala Arg Cys Glu Ala Gln Ile 
            20                  25                  30          


Asn Leu Leu Gly Glu Gly Gly Ile Cys Lys Leu Pro Gly Arg Leu Arg 
        35                  40                  45              


Ile Gln Pro Ala Leu Trp Ser Arg Glu Asp Val Leu His Trp Leu Arg 
    50                  55                  60                  


Trp Ala Glu Gln Glu Tyr Ser Leu Pro Cys Thr Ala Glu His Gly Phe 
65                  70                  75                  80  


Glu Met Asn Gly Arg Ala Leu Cys Ile Leu Thr Lys Asp Asp Phe Arg 
                85                  90                  95      


His Arg Ala Pro Ser Ser Gly Asp Val Leu Tyr Glu Leu Leu Gln Tyr 
            100                 105                 110         


Ile Lys Thr Gln Arg Arg Ala Leu Val Cys Gly Pro Phe Phe Gly Gly 
        115                 120                 125             


Ile Phe Arg Leu Lys Thr Pro Thr Gln His Ser Pro Val Pro Pro Glu 
    130                 135                 140                 


Glu Val Thr Gly Pro Ser Gln Met Asp Thr Arg Arg Gly His Leu Leu 
145                 150                 155                 160 


Gln Pro Pro Asp Pro Gly Leu Thr Ser Asn Phe Gly His Leu Asp Asp 
                165                 170                 175     


Pro Gly Leu Ala Arg Trp Thr Pro Gly Lys Glu Glu Ser Leu Asn Leu 
            180                 185                 190         


Cys His Cys Ala Glu Leu Gly Cys Arg Thr Gln Gly Val Cys Ser Phe 
        195                 200                 205             


Pro Ala Met Pro Gln Ala Pro Ile Asp Gly Arg Ile Ala Asp Cys Arg 
    210                 215                 220                 


Leu Leu Trp Asp Tyr Val Tyr Gln Leu Leu Leu Asp Thr Arg Tyr Glu 
225                 230                 235                 240 


Pro Tyr Ile Lys Trp Glu Asp Lys Asp Ala Lys Ile Phe Arg Val Val 
                245                 250                 255     


Asp Pro Asn Gly Leu Ala Arg Leu Trp Gly Asn His Lys Asn Arg Val 
            260                 265                 270         


Asn Met Thr Tyr Glu Lys Met Ser Arg Ala Leu Arg His Tyr Tyr Lys 
        275                 280                 285             


Leu Asn Ile Ile Lys Lys Glu Pro Gly Gln Lys Leu Leu Phe Arg Asn 
    290                 295                 300                 


Gly Leu Gln Leu Ile Phe Ile Phe Ile Trp Ser Phe Gln 
305                 310                 315         


<210>  32
<211>  262
<212>  PRT
<213>  Homo sapiens

<400>  32

Met Gln Glu Gly Glu Leu Ala Ile Ser Pro Ile Ser Pro Val Ala Ala 
1               5                   10                  15      


Met Pro Pro Leu Gly Thr His Val Gln Ala Arg Cys Glu Ala Gln Ile 
            20                  25                  30          


Asn Leu Leu Gly Glu Gly Gly Ile Cys Lys Leu Pro Gly Arg Leu Arg 
        35                  40                  45              


Asp Val Leu Tyr Glu Leu Leu Gln Tyr Ile Lys Thr Gln Arg Arg Ala 
    50                  55                  60                  


Leu Val Cys Gly Pro Phe Phe Gly Gly Ile Phe Arg Leu Lys Thr Pro 
65                  70                  75                  80  


Thr Gln His Ser Pro Val Pro Pro Glu Glu Val Thr Gly Pro Ser Gln 
                85                  90                  95      


Met Asp Thr Arg Arg Gly His Leu Leu Gln Pro Pro Asp Pro Gly Leu 
            100                 105                 110         


Thr Ser Asn Phe Gly His Leu Asp Asp Pro Gly Leu Ala Arg Trp Thr 
        115                 120                 125             


Pro Gly Lys Glu Glu Ser Leu Asn Leu Cys His Cys Ala Glu Leu Gly 
    130                 135                 140                 


Cys Arg Thr Gln Gly Val Cys Ser Phe Pro Ala Met Pro Gln Ala Pro 
145                 150                 155                 160 


Ile Asp Gly Arg Ile Ala Asp Cys Arg Leu Leu Trp Asp Tyr Val Tyr 
                165                 170                 175     


Gln Leu Leu Leu Asp Thr Arg Tyr Glu Pro Tyr Ile Lys Trp Glu Asp 
            180                 185                 190         


Lys Asp Ala Lys Ile Phe Arg Val Val Asp Pro Asn Gly Leu Ala Arg 
        195                 200                 205             


Leu Trp Gly Asn His Lys Asn Arg Val Asn Met Thr Tyr Glu Lys Met 
    210                 215                 220                 


Ser Arg Ala Leu Arg His Tyr Tyr Lys Leu Asn Ile Ile Lys Lys Glu 
225                 230                 235                 240 


Pro Gly Gln Lys Leu Leu Phe Arg Asn Gly Leu Gln Leu Ile Phe Ile 
                245                 250                 255     


Phe Ile Trp Ser Phe Gln 
            260         


<210>  33
<211>  888
<212>  PRT
<213>  Homo sapiens

<400>  33

Met Lys Val Ala Arg Phe Gln Lys Ile Pro Asn Gly Glu Asn Glu Thr 
1               5                   10                  15      


Met Ile Pro Val Leu Thr Ser Lys Lys Ala Ser Glu Leu Pro Val Ser 
            20                  25                  30          


Glu Val Ala Ser Ile Leu Gln Ala Asp Leu Gln Asn Gly Leu Asn Lys 
        35                  40                  45              


Cys Glu Val Ser His Arg Arg Ala Phe His Gly Trp Asn Glu Phe Asp 
    50                  55                  60                  


Ile Ser Glu Asp Glu Pro Leu Trp Lys Lys Tyr Ile Ser Gln Phe Lys 
65                  70                  75                  80  


Asn Pro Leu Ile Met Leu Leu Leu Ala Ser Ala Val Ile Ser Val Leu 
                85                  90                  95      


Met His Gln Phe Asp Asp Ala Val Ser Ile Thr Val Ala Ile Leu Ile 
            100                 105                 110         


Val Val Thr Val Ala Phe Val Gln Glu Tyr Arg Ser Glu Lys Ser Leu 
        115                 120                 125             


Glu Glu Leu Ser Lys Leu Val Pro Pro Glu Cys His Cys Val Arg Glu 
    130                 135                 140                 


Gly Lys Leu Glu His Thr Leu Ala Arg Asp Leu Val Pro Gly Asp Thr 
145                 150                 155                 160 


Val Cys Leu Ser Val Gly Asp Arg Val Pro Ala Asp Leu Arg Leu Phe 
                165                 170                 175     


Glu Ala Val Asp Leu Ser Ile Asp Glu Ser Ser Leu Thr Gly Glu Thr 
            180                 185                 190         


Thr Pro Cys Ser Lys Val Thr Ala Pro Gln Pro Ala Ala Thr Asn Gly 
        195                 200                 205             


Asp Leu Ala Ser Arg Ser Asn Ile Ala Phe Met Gly Thr Leu Val Arg 
    210                 215                 220                 


Cys Gly Lys Ala Lys Gly Val Val Ile Gly Thr Gly Glu Asn Ser Glu 
225                 230                 235                 240 


Phe Gly Glu Val Phe Lys Met Met Gln Ala Glu Glu Ala Pro Lys Thr 
                245                 250                 255     


Pro Leu Gln Lys Ser Met Asp Leu Leu Gly Lys Gln Leu Ser Phe Tyr 
            260                 265                 270         


Ser Phe Gly Ile Ile Gly Ile Ile Met Leu Val Gly Trp Leu Leu Gly 
        275                 280                 285             


Lys Asp Ile Leu Glu Met Phe Thr Ile Ser Val Ser Leu Ala Val Ala 
    290                 295                 300                 


Ala Ile Pro Glu Gly Leu Pro Ile Val Val Thr Val Thr Leu Ala Leu 
305                 310                 315                 320 


Gly Val Met Arg Met Val Lys Lys Arg Ala Ile Val Lys Lys Leu Pro 
                325                 330                 335     


Ile Val Glu Thr Leu Gly Cys Cys Asn Val Ile Cys Ser Asp Lys Thr 
            340                 345                 350         


Gly Thr Leu Thr Lys Asn Glu Met Thr Val Thr His Ile Phe Thr Ser 
        355                 360                 365             


Asp Gly Leu His Ala Glu Val Thr Gly Val Gly Tyr Asn Gln Phe Gly 
    370                 375                 380                 


Glu Val Ile Val Asp Gly Asp Val Val His Gly Phe Tyr Asn Pro Ala 
385                 390                 395                 400 


Val Ser Arg Ile Val Glu Ala Gly Cys Val Cys Asn Asp Ala Val Ile 
                405                 410                 415     


Arg Asn Asn Thr Leu Met Gly Lys Pro Thr Glu Gly Ala Leu Ile Ala 
            420                 425                 430         


Leu Ala Met Lys Met Gly Leu Asp Gly Leu Gln Gln Asp Tyr Ile Arg 
        435                 440                 445             


Lys Ala Glu Tyr Pro Phe Ser Ser Glu Gln Lys Trp Met Ala Val Lys 
    450                 455                 460                 


Cys Val His Arg Thr Gln Gln Asp Arg Pro Glu Ile Cys Phe Met Lys 
465                 470                 475                 480 


Gly Ala Tyr Glu Gln Val Ile Lys Tyr Cys Thr Thr Tyr Gln Ser Lys 
                485                 490                 495     


Gly Gln Thr Leu Thr Leu Thr Gln Gln Gln Arg Asp Val Tyr Gln Gln 
            500                 505                 510         


Glu Lys Ala Arg Met Gly Ser Ala Gly Leu Arg Val Leu Ala Leu Ala 
        515                 520                 525             


Ser Gly Pro Glu Leu Gly Gln Leu Thr Phe Leu Gly Leu Val Gly Ile 
    530                 535                 540                 


Ile Asp Pro Pro Arg Thr Gly Val Lys Glu Ala Val Thr Thr Leu Ile 
545                 550                 555                 560 


Ala Ser Gly Val Ser Ile Lys Met Ile Thr Gly Asp Ser Gln Glu Thr 
                565                 570                 575     


Ala Val Ala Ile Ala Ser Arg Leu Gly Leu Tyr Ser Lys Thr Ser Gln 
            580                 585                 590         


Ser Val Ser Gly Glu Glu Ile Asp Ala Met Asp Val Gln Gln Leu Ser 
        595                 600                 605             


Gln Ile Val Pro Lys Val Ala Val Phe Tyr Arg Ala Ser Pro Arg His 
    610                 615                 620                 


Lys Met Lys Ile Ile Lys Ser Leu Gln Lys Asn Gly Ser Val Val Ala 
625                 630                 635                 640 


Met Thr Gly Asp Gly Val Asn Asp Ala Val Ala Leu Lys Ala Ala Asp 
                645                 650                 655     


Ile Gly Val Ala Met Gly Gln Thr Gly Thr Asp Val Cys Lys Glu Ala 
            660                 665                 670         


Ala Asp Met Ile Leu Val Asp Asp Asp Phe Gln Thr Ile Met Ser Ala 
        675                 680                 685             


Ile Glu Glu Gly Lys Gly Ile Tyr Asn Asn Ile Lys Asn Phe Val Arg 
    690                 695                 700                 


Phe Gln Leu Ser Thr Ser Ile Ala Ala Leu Thr Leu Ile Ser Leu Ala 
705                 710                 715                 720 


Thr Leu Met Asn Phe Pro Asn Pro Leu Asn Ala Met Gln Ile Leu Trp 
                725                 730                 735     


Ile Asn Ile Ile Met Asp Gly Pro Pro Ala Gln Ser Leu Gly Val Glu 
            740                 745                 750         


Pro Val Asp Lys Asp Val Ile Arg Lys Pro Pro Arg Asn Trp Lys Asp 
        755                 760                 765             


Ser Ile Leu Thr Lys Asn Leu Ile Leu Lys Ile Leu Val Ser Ser Ile 
    770                 775                 780                 


Ile Ile Val Cys Gly Thr Leu Phe Val Phe Trp Arg Glu Leu Arg Asp 
785                 790                 795                 800 


Asn Val Ile Thr Pro Arg Asp Thr Thr Met Thr Phe Thr Cys Phe Val 
                805                 810                 815     


Phe Phe Asp Met Phe Asn Ala Leu Ser Ser Arg Ser Gln Thr Lys Ser 
            820                 825                 830         


Val Phe Glu Ile Gly Leu Cys Ser Asn Arg Met Phe Cys Tyr Ala Val 
        835                 840                 845             


Leu Gly Ser Ile Met Gly Gln Leu Leu Val Ile Tyr Phe Pro Pro Leu 
    850                 855                 860                 


Gln Lys Val Phe Gln Thr Glu Ser Leu Ser Ile Leu Gly Leu Ala Leu 
865                 870                 875                 880 


Gly Glu Glu Trp Thr Ala Ala Gly 
                885             


<210>  34
<211>  949
<212>  PRT
<213>  Homo sapiens

<400>  34

Met Lys Val Ala Arg Phe Gln Lys Ile Pro Asn Gly Glu Asn Glu Thr 
1               5                   10                  15      


Met Ile Pro Val Leu Thr Ser Lys Lys Ala Ser Glu Leu Pro Val Ser 
            20                  25                  30          


Glu Val Ala Ser Ile Leu Gln Ala Asp Leu Gln Asn Gly Leu Asn Lys 
        35                  40                  45              


Cys Glu Val Ser His Arg Arg Ala Phe His Gly Trp Asn Glu Phe Asp 
    50                  55                  60                  


Ile Ser Glu Asp Glu Pro Leu Trp Lys Lys Tyr Ile Ser Gln Phe Lys 
65                  70                  75                  80  


Asn Pro Leu Ile Met Leu Leu Leu Ala Ser Ala Val Ile Ser Val Leu 
                85                  90                  95      


Met His Gln Phe Asp Asp Ala Val Ser Ile Thr Val Ala Ile Leu Ile 
            100                 105                 110         


Val Val Thr Val Ala Phe Val Gln Glu Tyr Arg Ser Glu Lys Ser Leu 
        115                 120                 125             


Glu Glu Leu Ser Lys Leu Val Pro Pro Glu Cys His Cys Val Arg Glu 
    130                 135                 140                 


Gly Lys Leu Glu His Thr Leu Ala Arg Asp Leu Val Pro Gly Asp Thr 
145                 150                 155                 160 


Val Cys Leu Ser Val Gly Asp Arg Val Pro Ala Asp Leu Arg Leu Phe 
                165                 170                 175     


Glu Ala Val Asp Leu Ser Ile Asp Glu Ser Ser Leu Thr Gly Glu Thr 
            180                 185                 190         


Thr Pro Cys Ser Lys Val Thr Ala Pro Gln Pro Ala Ala Thr Asn Gly 
        195                 200                 205             


Asp Leu Ala Ser Arg Ser Asn Ile Ala Phe Met Gly Thr Leu Val Arg 
    210                 215                 220                 


Cys Gly Lys Ala Lys Gly Val Val Ile Gly Thr Gly Glu Asn Ser Glu 
225                 230                 235                 240 


Phe Gly Glu Val Phe Lys Met Met Gln Ala Glu Glu Ala Pro Lys Thr 
                245                 250                 255     


Pro Leu Gln Lys Ser Met Asp Leu Leu Gly Lys Gln Leu Ser Phe Tyr 
            260                 265                 270         


Ser Phe Gly Ile Ile Gly Ile Ile Met Leu Val Gly Trp Leu Leu Gly 
        275                 280                 285             


Lys Asp Ile Leu Glu Met Phe Thr Ile Ser Val Ser Leu Ala Val Ala 
    290                 295                 300                 


Ala Ile Pro Glu Gly Leu Pro Ile Val Val Thr Val Thr Leu Ala Leu 
305                 310                 315                 320 


Gly Val Met Arg Met Val Lys Lys Arg Ala Ile Val Lys Lys Leu Pro 
                325                 330                 335     


Ile Val Glu Thr Leu Gly Cys Cys Asn Val Ile Cys Ser Asp Lys Thr 
            340                 345                 350         


Gly Thr Leu Thr Lys Asn Glu Met Thr Val Thr His Ile Phe Thr Ser 
        355                 360                 365             


Asp Gly Leu His Ala Glu Val Thr Gly Val Gly Tyr Asn Gln Phe Gly 
    370                 375                 380                 


Glu Val Ile Val Asp Gly Asp Val Val His Gly Phe Tyr Asn Pro Ala 
385                 390                 395                 400 


Val Ser Arg Ile Val Glu Ala Gly Cys Val Cys Asn Asp Ala Val Ile 
                405                 410                 415     


Arg Asn Asn Thr Leu Met Gly Lys Pro Thr Glu Gly Ala Leu Ile Ala 
            420                 425                 430         


Leu Ala Met Lys Met Gly Leu Asp Gly Leu Gln Gln Asp Tyr Ile Arg 
        435                 440                 445             


Lys Ala Glu Tyr Pro Phe Ser Ser Glu Gln Lys Trp Met Ala Val Lys 
    450                 455                 460                 


Cys Val His Arg Thr Gln Gln Asp Arg Pro Glu Ile Cys Phe Met Lys 
465                 470                 475                 480 


Gly Ala Tyr Glu Gln Val Ile Lys Tyr Cys Thr Thr Tyr Gln Ser Lys 
                485                 490                 495     


Gly Gln Thr Leu Thr Leu Thr Gln Gln Gln Arg Asp Val Tyr Gln Gln 
            500                 505                 510         


Glu Lys Ala Arg Met Gly Ser Ala Gly Leu Arg Val Leu Ala Leu Ala 
        515                 520                 525             


Ser Gly Pro Glu Leu Gly Gln Leu Thr Phe Leu Gly Leu Val Gly Ile 
    530                 535                 540                 


Ile Asp Pro Pro Arg Thr Gly Val Lys Glu Ala Val Thr Thr Leu Ile 
545                 550                 555                 560 


Ala Ser Gly Val Ser Ile Lys Met Ile Thr Gly Asp Ser Gln Glu Thr 
                565                 570                 575     


Ala Val Ala Ile Ala Ser Arg Leu Gly Leu Tyr Ser Lys Thr Ser Gln 
            580                 585                 590         


Ser Val Ser Gly Glu Glu Ile Asp Ala Met Asp Val Gln Gln Leu Ser 
        595                 600                 605             


Gln Ile Val Pro Lys Val Ala Val Phe Tyr Arg Ala Ser Pro Arg His 
    610                 615                 620                 


Lys Met Lys Ile Ile Lys Ser Leu Gln Lys Asn Gly Ser Val Val Ala 
625                 630                 635                 640 


Met Thr Gly Asp Gly Val Asn Asp Ala Val Ala Leu Lys Ala Ala Asp 
                645                 650                 655     


Ile Gly Val Ala Met Gly Gln Thr Gly Thr Asp Val Cys Lys Glu Ala 
            660                 665                 670         


Ala Asp Met Ile Leu Val Asp Asp Asp Phe Gln Thr Ile Met Ser Ala 
        675                 680                 685             


Ile Glu Glu Gly Lys Gly Ile Tyr Asn Asn Ile Lys Asn Phe Val Arg 
    690                 695                 700                 


Phe Gln Leu Ser Thr Ser Ile Ala Ala Leu Thr Leu Ile Ser Leu Ala 
705                 710                 715                 720 


Thr Leu Met Asn Phe Pro Asn Pro Leu Asn Ala Met Gln Ile Leu Trp 
                725                 730                 735     


Ile Asn Ile Ile Met Asp Gly Pro Pro Ala Gln Ser Leu Gly Val Glu 
            740                 745                 750         


Pro Val Asp Lys Asp Val Ile Arg Lys Pro Pro Arg Asn Trp Lys Asp 
        755                 760                 765             


Ser Ile Leu Thr Lys Asn Leu Ile Leu Lys Ile Leu Val Ser Ser Ile 
    770                 775                 780                 


Ile Ile Val Cys Gly Thr Leu Phe Val Phe Trp Arg Glu Leu Arg Asp 
785                 790                 795                 800 


Asn Val Ile Thr Pro Arg Asp Thr Thr Met Thr Phe Thr Cys Phe Val 
                805                 810                 815     


Phe Phe Asp Met Phe Asn Ala Leu Ser Ser Arg Ser Gln Thr Lys Ser 
            820                 825                 830         


Val Phe Glu Ile Gly Leu Cys Ser Asn Arg Met Phe Cys Tyr Ala Val 
        835                 840                 845             


Leu Gly Ser Ile Met Gly Gln Leu Leu Val Ile Tyr Phe Pro Pro Leu 
    850                 855                 860                 


Gln Lys Val Phe Gln Thr Glu Ser Leu Ser Ile Leu Asp Leu Leu Phe 
865                 870                 875                 880 


Leu Leu Gly Leu Thr Ser Ser Val Cys Ile Val Ala Glu Ile Ile Lys 
                885                 890                 895     


Lys Val Glu Arg Ser Arg Glu Lys Ile Gln Lys His Val Ser Ser Thr 
            900                 905                 910         


Ser Ser Ser Phe Leu Glu Val Trp Leu Trp Glu Arg Ser Gly Gln Gln 
        915                 920                 925             


Leu Val Glu Ile His Pro His Leu Glu Thr Gly Leu Pro Leu Thr Glu 
    930                 935                 940                 


Asp Val Ser Cys Val 
945                 


<210>  35
<211>  939
<212>  PRT
<213>  Homo sapiens

<400>  35

Met Lys Val Ala Arg Phe Gln Lys Ile Pro Asn Gly Glu Asn Glu Thr 
1               5                   10                  15      


Met Ile Pro Val Leu Thr Ser Lys Lys Ala Ser Glu Leu Pro Val Ser 
            20                  25                  30          


Glu Val Ala Ser Ile Leu Gln Ala Asp Leu Gln Asn Gly Leu Asn Lys 
        35                  40                  45              


Cys Glu Val Ser His Arg Arg Ala Phe His Gly Trp Asn Glu Phe Asp 
    50                  55                  60                  


Ile Ser Glu Asp Glu Pro Leu Trp Lys Lys Tyr Ile Ser Gln Phe Lys 
65                  70                  75                  80  


Asn Pro Leu Ile Met Leu Leu Leu Ala Ser Ala Val Ile Ser Val Leu 
                85                  90                  95      


Met His Gln Phe Asp Asp Ala Val Ser Ile Thr Val Ala Ile Leu Ile 
            100                 105                 110         


Val Val Thr Val Ala Phe Val Gln Glu Tyr Arg Ser Glu Lys Ser Leu 
        115                 120                 125             


Glu Glu Leu Ser Lys Leu Val Pro Pro Glu Cys His Cys Val Arg Glu 
    130                 135                 140                 


Gly Lys Leu Glu His Thr Leu Ala Arg Asp Leu Val Pro Gly Asp Thr 
145                 150                 155                 160 


Val Cys Leu Ser Val Gly Asp Arg Val Pro Ala Asp Leu Arg Leu Phe 
                165                 170                 175     


Glu Ala Val Asp Leu Ser Ile Asp Glu Ser Ser Leu Thr Gly Glu Thr 
            180                 185                 190         


Thr Pro Cys Ser Lys Val Thr Ala Pro Gln Pro Ala Ala Thr Asn Gly 
        195                 200                 205             


Asp Leu Ala Ser Arg Ser Asn Ile Ala Phe Met Gly Thr Leu Val Arg 
    210                 215                 220                 


Cys Gly Lys Ala Lys Gly Val Val Ile Gly Thr Gly Glu Asn Ser Glu 
225                 230                 235                 240 


Phe Gly Glu Val Phe Lys Met Met Gln Ala Glu Glu Ala Pro Lys Thr 
                245                 250                 255     


Pro Leu Gln Lys Ser Met Asp Leu Leu Gly Lys Gln Leu Ser Phe Tyr 
            260                 265                 270         


Ser Phe Gly Ile Ile Gly Ile Ile Met Leu Val Gly Trp Leu Leu Gly 
        275                 280                 285             


Lys Asp Ile Leu Glu Met Phe Thr Ile Ser Val Ser Leu Ala Val Ala 
    290                 295                 300                 


Ala Ile Pro Glu Gly Leu Pro Ile Val Val Thr Val Thr Leu Ala Leu 
305                 310                 315                 320 


Gly Val Met Arg Met Val Lys Lys Arg Ala Ile Val Lys Lys Leu Pro 
                325                 330                 335     


Ile Val Glu Thr Leu Gly Cys Cys Asn Val Ile Cys Ser Asp Lys Thr 
            340                 345                 350         


Gly Thr Leu Thr Lys Asn Glu Met Thr Val Thr His Ile Phe Thr Ser 
        355                 360                 365             


Asp Gly Leu His Ala Glu Val Thr Gly Val Gly Tyr Asn Gln Phe Gly 
    370                 375                 380                 


Glu Val Ile Val Asp Gly Asp Val Val His Gly Phe Tyr Asn Pro Ala 
385                 390                 395                 400 


Val Ser Arg Ile Val Glu Ala Gly Cys Val Cys Asn Asp Ala Val Ile 
                405                 410                 415     


Arg Asn Asn Thr Leu Met Gly Lys Pro Thr Glu Gly Ala Leu Ile Ala 
            420                 425                 430         


Leu Ala Met Lys Met Gly Leu Asp Gly Leu Gln Gln Asp Tyr Ile Arg 
        435                 440                 445             


Lys Ala Glu Tyr Pro Phe Ser Ser Glu Gln Lys Trp Met Ala Val Lys 
    450                 455                 460                 


Cys Val His Arg Thr Gln Gln Asp Arg Pro Glu Ile Cys Phe Met Lys 
465                 470                 475                 480 


Gly Ala Tyr Glu Gln Val Ile Lys Tyr Cys Thr Thr Tyr Gln Ser Lys 
                485                 490                 495     


Gly Gln Thr Leu Thr Leu Thr Gln Gln Gln Arg Asp Val Tyr Gln Gln 
            500                 505                 510         


Glu Lys Ala Arg Met Gly Ser Ala Gly Leu Arg Val Leu Ala Leu Ala 
        515                 520                 525             


Ser Gly Pro Glu Leu Gly Gln Leu Thr Phe Leu Gly Leu Val Gly Ile 
    530                 535                 540                 


Ile Asp Pro Pro Arg Thr Gly Val Lys Glu Ala Val Thr Thr Leu Ile 
545                 550                 555                 560 


Ala Ser Gly Val Ser Ile Lys Met Ile Thr Gly Asp Ser Gln Glu Thr 
                565                 570                 575     


Ala Val Ala Ile Ala Ser Arg Leu Gly Leu Tyr Ser Lys Thr Ser Gln 
            580                 585                 590         


Ser Val Ser Gly Glu Glu Ile Asp Ala Met Asp Val Gln Gln Leu Ser 
        595                 600                 605             


Gln Ile Val Pro Lys Val Ala Val Phe Tyr Arg Ala Ser Pro Arg His 
    610                 615                 620                 


Lys Met Lys Ile Ile Lys Ser Leu Gln Lys Asn Gly Ser Val Val Ala 
625                 630                 635                 640 


Met Thr Gly Asp Gly Val Asn Asp Ala Val Ala Leu Lys Ala Ala Asp 
                645                 650                 655     


Ile Gly Val Ala Met Gly Gln Thr Gly Thr Asp Val Cys Lys Glu Ala 
            660                 665                 670         


Ala Asp Met Ile Leu Val Asp Asp Asp Phe Gln Thr Ile Met Ser Ala 
        675                 680                 685             


Ile Glu Glu Gly Lys Gly Ile Tyr Asn Asn Ile Lys Asn Phe Val Arg 
    690                 695                 700                 


Phe Gln Leu Ser Thr Ser Ile Ala Ala Leu Thr Leu Ile Ser Leu Ala 
705                 710                 715                 720 


Thr Leu Met Asn Phe Pro Asn Pro Leu Asn Ala Met Gln Ile Leu Trp 
                725                 730                 735     


Ile Asn Ile Ile Met Asp Gly Pro Pro Ala Gln Ser Leu Gly Val Glu 
            740                 745                 750         


Pro Val Asp Lys Asp Val Ile Arg Lys Pro Pro Arg Asn Trp Lys Asp 
        755                 760                 765             


Ser Ile Leu Thr Lys Asn Leu Ile Leu Lys Ile Leu Val Ser Ser Ile 
    770                 775                 780                 


Ile Ile Val Cys Gly Thr Leu Phe Val Phe Trp Arg Glu Leu Arg Asp 
785                 790                 795                 800 


Asn Val Ile Thr Pro Arg Asp Thr Thr Met Thr Phe Thr Cys Phe Val 
                805                 810                 815     


Phe Phe Asp Met Phe Asn Ala Leu Ser Ser Arg Ser Gln Thr Lys Ser 
            820                 825                 830         


Val Phe Glu Ile Gly Leu Cys Ser Asn Arg Met Phe Cys Tyr Ala Val 
        835                 840                 845             


Leu Gly Ser Ile Met Gly Gln Leu Leu Val Ile Tyr Phe Pro Pro Leu 
    850                 855                 860                 


Gln Lys Val Phe Gln Thr Glu Ser Leu Ser Ile Leu Asp Leu Leu Phe 
865                 870                 875                 880 


Leu Leu Gly Leu Thr Ser Ser Val Cys Ile Val Ala Glu Ile Ile Lys 
                885                 890                 895     


Lys Val Glu Arg Ser Arg Glu Lys Ile Gln Lys His Val Trp Leu Trp 
            900                 905                 910         


Glu Arg Ser Gly Gln Gln Leu Val Glu Ile His Pro His Leu Glu Thr 
        915                 920                 925             


Gly Leu Pro Leu Thr Glu Asp Val Ser Cys Val 
    930                 935                 


<210>  36
<211>  919
<212>  PRT
<213>  Homo sapiens

<400>  36

Met Lys Val Ala Arg Phe Gln Lys Ile Pro Asn Gly Glu Asn Glu Thr 
1               5                   10                  15      


Met Ile Pro Val Leu Thr Ser Lys Lys Ala Ser Glu Leu Pro Val Ser 
            20                  25                  30          


Glu Val Ala Ser Ile Leu Gln Ala Asp Leu Gln Asn Gly Leu Asn Lys 
        35                  40                  45              


Cys Glu Val Ser His Arg Arg Ala Phe His Gly Trp Asn Glu Phe Asp 
    50                  55                  60                  


Ile Ser Glu Asp Glu Pro Leu Trp Lys Lys Tyr Ile Ser Gln Phe Lys 
65                  70                  75                  80  


Asn Pro Leu Ile Met Leu Leu Leu Ala Ser Ala Val Ile Ser Val Leu 
                85                  90                  95      


Met His Gln Phe Asp Asp Ala Val Ser Ile Thr Val Ala Ile Leu Ile 
            100                 105                 110         


Val Val Thr Val Ala Phe Val Gln Glu Tyr Arg Ser Glu Lys Ser Leu 
        115                 120                 125             


Glu Glu Leu Ser Lys Leu Val Pro Pro Glu Cys His Cys Val Arg Glu 
    130                 135                 140                 


Gly Lys Leu Glu His Thr Leu Ala Arg Asp Leu Val Pro Gly Asp Thr 
145                 150                 155                 160 


Val Cys Leu Ser Val Gly Asp Arg Val Pro Ala Asp Leu Arg Leu Phe 
                165                 170                 175     


Glu Ala Val Asp Leu Ser Ile Asp Glu Ser Ser Leu Thr Gly Glu Thr 
            180                 185                 190         


Thr Pro Cys Ser Lys Val Thr Ala Pro Gln Pro Ala Ala Thr Asn Gly 
        195                 200                 205             


Asp Leu Ala Ser Arg Ser Asn Ile Ala Phe Met Gly Thr Leu Val Arg 
    210                 215                 220                 


Cys Gly Lys Ala Lys Gly Val Val Ile Gly Thr Gly Glu Asn Ser Glu 
225                 230                 235                 240 


Phe Gly Glu Val Phe Lys Met Met Gln Ala Glu Glu Ala Pro Lys Thr 
                245                 250                 255     


Pro Leu Gln Lys Ser Met Asp Leu Leu Gly Lys Gln Leu Ser Phe Tyr 
            260                 265                 270         


Ser Phe Gly Ile Ile Gly Ile Ile Met Leu Val Gly Trp Leu Leu Gly 
        275                 280                 285             


Lys Asp Ile Leu Glu Met Phe Thr Ile Ser Val Ser Leu Ala Val Ala 
    290                 295                 300                 


Ala Ile Pro Glu Gly Leu Pro Ile Val Val Thr Val Thr Leu Ala Leu 
305                 310                 315                 320 


Gly Val Met Arg Met Val Lys Lys Arg Ala Ile Val Lys Lys Leu Pro 
                325                 330                 335     


Ile Val Glu Thr Leu Gly Cys Cys Asn Val Ile Cys Ser Asp Lys Thr 
            340                 345                 350         


Gly Thr Leu Thr Lys Asn Glu Met Thr Val Thr His Ile Phe Thr Ser 
        355                 360                 365             


Asp Gly Leu His Ala Glu Val Thr Gly Val Gly Tyr Asn Gln Phe Gly 
    370                 375                 380                 


Glu Val Ile Val Asp Gly Asp Val Val His Gly Phe Tyr Asn Pro Ala 
385                 390                 395                 400 


Val Ser Arg Ile Val Glu Ala Gly Cys Val Cys Asn Asp Ala Val Ile 
                405                 410                 415     


Arg Asn Asn Thr Leu Met Gly Lys Pro Thr Glu Gly Ala Leu Ile Ala 
            420                 425                 430         


Leu Ala Met Lys Met Gly Leu Asp Gly Leu Gln Gln Asp Tyr Ile Arg 
        435                 440                 445             


Lys Ala Glu Tyr Pro Phe Ser Ser Glu Gln Lys Trp Met Ala Val Lys 
    450                 455                 460                 


Cys Val His Arg Thr Gln Gln Asp Arg Pro Glu Ile Cys Phe Met Lys 
465                 470                 475                 480 


Gly Ala Tyr Glu Gln Val Ile Lys Tyr Cys Thr Thr Tyr Gln Ser Lys 
                485                 490                 495     


Gly Gln Thr Leu Thr Leu Thr Gln Gln Gln Arg Asp Val Tyr Gln Gln 
            500                 505                 510         


Glu Lys Ala Arg Met Gly Ser Ala Gly Leu Arg Val Leu Ala Leu Ala 
        515                 520                 525             


Ser Gly Pro Glu Leu Gly Gln Leu Thr Phe Leu Gly Leu Val Gly Ile 
    530                 535                 540                 


Ile Asp Pro Pro Arg Thr Gly Val Lys Glu Ala Val Thr Thr Leu Ile 
545                 550                 555                 560 


Ala Ser Gly Val Ser Ile Lys Met Ile Thr Gly Asp Ser Gln Glu Thr 
                565                 570                 575     


Ala Val Ala Ile Ala Ser Arg Leu Gly Leu Tyr Ser Lys Thr Ser Gln 
            580                 585                 590         


Ser Val Ser Gly Glu Glu Ile Asp Ala Met Asp Val Gln Gln Leu Ser 
        595                 600                 605             


Gln Ile Val Pro Lys Val Ala Val Phe Tyr Arg Ala Ser Pro Arg His 
    610                 615                 620                 


Lys Met Lys Ile Ile Lys Ser Leu Gln Lys Asn Gly Ser Val Val Ala 
625                 630                 635                 640 


Met Thr Gly Asp Gly Val Asn Asp Ala Val Ala Leu Lys Ala Ala Asp 
                645                 650                 655     


Ile Gly Val Ala Met Gly Gln Thr Gly Thr Asp Val Cys Lys Glu Ala 
            660                 665                 670         


Ala Asp Met Ile Leu Val Asp Asp Asp Phe Gln Thr Ile Met Ser Ala 
        675                 680                 685             


Ile Glu Glu Gly Lys Gly Ile Tyr Asn Asn Ile Lys Asn Phe Val Arg 
    690                 695                 700                 


Phe Gln Leu Ser Thr Ser Ile Ala Ala Leu Thr Leu Ile Ser Leu Ala 
705                 710                 715                 720 


Thr Leu Met Asn Phe Pro Asn Pro Leu Asn Ala Met Gln Ile Leu Trp 
                725                 730                 735     


Ile Asn Ile Ile Met Asp Gly Pro Pro Ala Gln Ser Leu Gly Val Glu 
            740                 745                 750         


Pro Val Asp Lys Asp Val Ile Arg Lys Pro Pro Arg Asn Trp Lys Asp 
        755                 760                 765             


Ser Ile Leu Thr Lys Asn Leu Ile Leu Lys Ile Leu Val Ser Ser Ile 
    770                 775                 780                 


Ile Ile Val Cys Gly Thr Leu Phe Val Phe Trp Arg Glu Leu Arg Asp 
785                 790                 795                 800 


Asn Val Ile Thr Pro Arg Asp Thr Thr Met Thr Phe Thr Cys Phe Val 
                805                 810                 815     


Phe Phe Asp Met Phe Asn Ala Leu Ser Ser Arg Ser Gln Thr Lys Ser 
            820                 825                 830         


Val Phe Glu Ile Gly Leu Cys Ser Asn Arg Met Phe Cys Tyr Ala Val 
        835                 840                 845             


Leu Gly Ser Ile Met Gly Gln Leu Leu Val Ile Tyr Phe Pro Pro Leu 
    850                 855                 860                 


Gln Lys Val Phe Gln Thr Glu Ser Leu Ser Ile Leu Asp Leu Leu Phe 
865                 870                 875                 880 


Leu Leu Gly Leu Thr Ser Ser Val Cys Ile Val Ala Glu Ile Ile Lys 
                885                 890                 895     


Lys Val Glu Arg Ser Arg Glu Lys Ile Gln Lys His Val Ser Ser Thr 
            900                 905                 910         


Ser Ser Ser Phe Leu Glu Val 
        915                 


<210>  37
<211>  944
<212>  PRT
<213>  Homo sapiens

<400>  37

Met Asp Ser Leu Leu Pro Pro Ser Arg Phe Ser Tyr Phe Lys Lys Tyr 
1               5                   10                  15      


Pro Leu His Ala Ile Arg Arg Tyr Leu Ser Thr Leu Arg Asn Gln Arg 
            20                  25                  30          


Ala Glu Glu Gln Val Ala Arg Phe Gln Lys Ile Pro Asn Gly Glu Asn 
        35                  40                  45              


Glu Thr Met Ile Pro Val Leu Thr Ser Lys Lys Ala Ser Glu Leu Pro 
    50                  55                  60                  


Val Ser Glu Val Ala Ser Ile Leu Gln Phe Lys Asn Pro Leu Ile Met 
65                  70                  75                  80  


Leu Leu Leu Ala Ser Ala Val Ile Ser Val Leu Met His Gln Phe Asp 
                85                  90                  95      


Asp Ala Val Ser Ile Thr Val Ala Ile Leu Ile Val Val Thr Val Ala 
            100                 105                 110         


Phe Val Gln Glu Tyr Arg Ser Glu Lys Ser Leu Glu Glu Leu Ser Lys 
        115                 120                 125             


Leu Val Pro Pro Glu Cys His Cys Val Arg Glu Gly Lys Leu Glu His 
    130                 135                 140                 


Thr Leu Ala Arg Asp Leu Val Pro Gly Asp Thr Val Cys Leu Ser Val 
145                 150                 155                 160 


Gly Asp Arg Val Pro Ala Asp Leu Arg Leu Phe Glu Ala Val Asp Leu 
                165                 170                 175     


Ser Ile Asp Glu Ser Ser Leu Thr Gly Glu Thr Thr Pro Cys Ser Lys 
            180                 185                 190         


Val Thr Ala Pro Gln Pro Ala Ala Thr Asn Gly Asp Leu Ala Ser Arg 
        195                 200                 205             


Ser Asn Ile Ala Phe Met Gly Thr Leu Val Arg Cys Gly Lys Ala Lys 
    210                 215                 220                 


Gly Val Val Ile Gly Thr Gly Glu Asn Ser Glu Phe Gly Glu Val Phe 
225                 230                 235                 240 


Lys Met Met Gln Ala Glu Glu Ala Pro Lys Thr Pro Leu Gln Lys Ser 
                245                 250                 255     


Met Asp Leu Leu Gly Lys Gln Leu Ser Phe Tyr Ser Phe Gly Ile Ile 
            260                 265                 270         


Gly Ile Ile Met Leu Val Gly Trp Leu Leu Gly Lys Asp Ile Leu Glu 
        275                 280                 285             


Met Phe Thr Ile Ser Val Ser Leu Ala Val Ala Ala Ile Pro Glu Gly 
    290                 295                 300                 


Leu Pro Ile Val Val Thr Val Thr Leu Ala Leu Gly Val Met Arg Met 
305                 310                 315                 320 


Val Lys Lys Arg Ala Ile Val Lys Lys Leu Pro Ile Val Glu Thr Leu 
                325                 330                 335     


Gly Cys Cys Asn Val Ile Cys Ser Asp Lys Thr Gly Thr Leu Thr Lys 
            340                 345                 350         


Asn Glu Met Thr Val Thr His Ile Phe Thr Ser Asp Gly Leu His Ala 
        355                 360                 365             


Glu Val Thr Gly Val Gly Tyr Asn Gln Phe Gly Glu Val Ile Val Asp 
    370                 375                 380                 


Gly Asp Val Val His Gly Phe Tyr Asn Pro Ala Val Ser Arg Ile Val 
385                 390                 395                 400 


Glu Ala Gly Cys Val Cys Asn Asp Ala Val Ile Arg Asn Asn Thr Leu 
                405                 410                 415     


Met Gly Lys Pro Thr Glu Gly Ala Leu Ile Ala Leu Ala Met Lys Met 
            420                 425                 430         


Gly Leu Asp Gly Leu Gln Gln Asp Tyr Ile Arg Lys Ala Glu Tyr Pro 
        435                 440                 445             


Phe Ser Ser Glu Gln Lys Trp Met Ala Val Lys Cys Val His Arg Thr 
    450                 455                 460                 


Gln Gln Asp Arg Pro Glu Ile Cys Phe Met Lys Gly Ala Tyr Glu Gln 
465                 470                 475                 480 


Val Ile Lys Tyr Cys Thr Thr Tyr Gln Ser Lys Gly Gln Thr Leu Thr 
                485                 490                 495     


Leu Thr Gln Gln Gln Arg Asp Val Tyr Gln Gln Glu Lys Ala Arg Met 
            500                 505                 510         


Gly Ser Ala Gly Leu Arg Val Leu Ala Leu Ala Ser Gly Pro Glu Leu 
        515                 520                 525             


Gly Gln Leu Thr Phe Leu Gly Leu Val Gly Ile Ile Asp Pro Pro Arg 
    530                 535                 540                 


Thr Gly Val Lys Glu Ala Val Thr Thr Leu Ile Ala Ser Gly Val Ser 
545                 550                 555                 560 


Ile Lys Met Ile Thr Gly Asp Ser Gln Glu Thr Ala Val Ala Ile Ala 
                565                 570                 575     


Ser Arg Leu Gly Leu Tyr Ser Lys Thr Ser Gln Ser Val Ser Gly Glu 
            580                 585                 590         


Glu Ile Asp Ala Met Asp Val Gln Gln Leu Ser Gln Ile Val Pro Lys 
        595                 600                 605             


Val Ala Val Phe Tyr Arg Ala Ser Pro Arg His Lys Met Lys Ile Ile 
    610                 615                 620                 


Lys Ser Leu Gln Lys Asn Gly Ser Val Val Ala Met Thr Gly Asp Gly 
625                 630                 635                 640 


Val Asn Asp Ala Val Ala Leu Lys Ala Ala Asp Ile Gly Val Ala Met 
                645                 650                 655     


Gly Gln Thr Gly Thr Asp Val Cys Lys Glu Ala Ala Asp Met Ile Leu 
            660                 665                 670         


Val Asp Asp Asp Phe Gln Thr Ile Met Ser Ala Ile Glu Glu Gly Lys 
        675                 680                 685             


Gly Ile Tyr Asn Asn Ile Lys Asn Phe Val Arg Phe Gln Leu Ser Thr 
    690                 695                 700                 


Ser Ile Ala Ala Leu Thr Leu Ile Ser Leu Ala Thr Leu Met Asn Phe 
705                 710                 715                 720 


Pro Asn Pro Leu Asn Ala Met Gln Ile Leu Trp Ile Asn Ile Ile Met 
                725                 730                 735     


Asp Gly Pro Pro Ala Gln Ser Leu Gly Val Glu Pro Val Asp Lys Asp 
            740                 745                 750         


Val Ile Arg Lys Pro Pro Arg Asn Trp Lys Asp Ser Ile Leu Thr Lys 
        755                 760                 765             


Asn Leu Ile Leu Lys Ile Leu Val Ser Ser Ile Ile Ile Val Cys Gly 
    770                 775                 780                 


Thr Leu Phe Val Phe Trp Arg Glu Leu Arg Asp Asn Val Ile Thr Pro 
785                 790                 795                 800 


Arg Asp Thr Thr Met Thr Phe Thr Cys Phe Val Phe Phe Asp Met Phe 
                805                 810                 815     


Asn Ala Leu Ser Ser Arg Ser Gln Thr Lys Ser Val Phe Glu Ile Gly 
            820                 825                 830         


Leu Cys Ser Asn Arg Met Phe Cys Tyr Ala Val Leu Gly Ser Ile Met 
        835                 840                 845             


Gly Gln Leu Leu Val Ile Tyr Phe Pro Pro Leu Gln Lys Val Phe Gln 
    850                 855                 860                 


Thr Glu Ser Leu Ser Ile Leu Asp Leu Leu Phe Leu Leu Gly Leu Thr 
865                 870                 875                 880 


Ser Ser Val Cys Ile Val Ala Glu Ile Ile Lys Lys Val Glu Arg Ser 
                885                 890                 895     


Arg Glu Lys Ile Gln Lys His Val Ser Ser Thr Ser Ser Ser Phe Leu 
            900                 905                 910         


Glu Val Trp Leu Trp Glu Arg Ser Gly Gln Gln Leu Val Glu Ile His 
        915                 920                 925             


Pro His Leu Glu Thr Gly Leu Pro Leu Thr Glu Asp Val Ser Cys Val 
    930                 935                 940                 


<210>  38
<211>  215
<212>  PRT
<213>  Homo sapiens

<400>  38

Val Thr Val Thr Leu Ala Leu Gly Val Met Arg Met Val Lys Lys Arg 
1               5                   10                  15      


Ala Ile Val Lys Lys Leu Pro Ile Val Glu Thr Leu Gly Cys Cys Asn 
            20                  25                  30          


Val Ile Cys Ser Asp Lys Thr Gly Thr Leu Thr Lys Asn Glu Met Thr 
        35                  40                  45              


Val Thr His Ile Phe Thr Ser Asp Gly Leu His Ala Glu Val Thr Gly 
    50                  55                  60                  


Val Gly Tyr Asn Gln Phe Gly Glu Val Ile Val Asp Gly Asp Val Val 
65                  70                  75                  80  


His Gly Phe Tyr Asn Pro Ala Val Ser Arg Ile Val Glu Ala Gly Cys 
                85                  90                  95      


Val Cys Asn Asp Ala Val Ile Arg Asn Asn Thr Leu Met Gly Lys Pro 
            100                 105                 110         


Thr Glu Gly Ala Leu Ile Ala Leu Ala Met Lys Met Gly Leu Asp Gly 
        115                 120                 125             


Leu Gln Gln Asp Tyr Ile Arg Lys Ala Glu Tyr Pro Phe Ser Ser Glu 
    130                 135                 140                 


Gln Lys Trp Met Ala Val Lys Cys Val His Arg Thr Gln Gln Asp Arg 
145                 150                 155                 160 


Pro Glu Ile Cys Phe Met Lys Gly Ala Tyr Glu Gln Val Ile Lys Tyr 
                165                 170                 175     


Cys Thr Thr Tyr Gln Ser Lys Gly Gln Thr Leu Thr Leu Thr Gln Gln 
            180                 185                 190         


Gln Arg Asp Val Tyr Gln Gln Glu Lys Ala Arg Met Gly Ser Ala Gly 
        195                 200                 205             


Leu Arg Val Tyr Leu Val Phe 
    210                 215 


<210>  39
<211>  903
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  39

Xaa Lys Cys Glu Val Ser His Arg Arg Ala Phe His Gly Trp Asn Glu 
1               5                   10                  15      


Phe Asp Ile Ser Glu Asp Glu Pro Leu Trp Lys Lys Tyr Ile Ser Gln 
            20                  25                  30          


Phe Lys Asn Pro Leu Ile Met Leu Leu Leu Ala Ser Ala Val Ile Ser 
        35                  40                  45              


Val Leu Met His Gln Phe Asp Asp Ala Val Ser Ile Thr Val Ala Ile 
    50                  55                  60                  


Leu Ile Val Val Thr Val Ala Phe Val Gln Glu Tyr Arg Ser Glu Lys 
65                  70                  75                  80  


Ser Leu Glu Glu Leu Ser Lys Leu Val Pro Pro Glu Cys His Cys Val 
                85                  90                  95      


Arg Glu Gly Lys Leu Glu His Thr Leu Ala Arg Asp Leu Val Pro Gly 
            100                 105                 110         


Asp Thr Val Cys Leu Ser Val Gly Asp Arg Val Pro Ala Asp Leu Arg 
        115                 120                 125             


Leu Phe Glu Ala Val Asp Leu Ser Ile Asp Glu Ser Ser Leu Thr Gly 
    130                 135                 140                 


Glu Thr Thr Pro Cys Ser Lys Val Thr Ala Pro Gln Pro Ala Ala Thr 
145                 150                 155                 160 


Asn Gly Asp Leu Ala Ser Arg Ser Asn Ile Ala Phe Met Gly Thr Leu 
                165                 170                 175     


Val Arg Cys Gly Lys Ala Lys Gly Val Val Ile Gly Thr Gly Glu Asn 
            180                 185                 190         


Ser Glu Phe Gly Glu Val Phe Lys Met Met Gln Ala Glu Glu Ala Pro 
        195                 200                 205             


Lys Thr Pro Leu Gln Lys Ser Met Asp Leu Leu Gly Lys Gln Leu Ser 
    210                 215                 220                 


Phe Tyr Ser Phe Gly Ile Ile Gly Ile Ile Met Leu Val Gly Trp Leu 
225                 230                 235                 240 


Leu Gly Lys Asp Ile Leu Glu Met Phe Thr Ile Ser Val Ser Leu Ala 
                245                 250                 255     


Val Ala Ala Ile Pro Glu Gly Leu Pro Ile Val Val Thr Val Thr Leu 
            260                 265                 270         


Ala Leu Gly Val Met Arg Met Val Lys Lys Arg Ala Ile Val Lys Lys 
        275                 280                 285             


Leu Pro Ile Val Glu Thr Leu Gly Cys Cys Asn Val Ile Cys Ser Asp 
    290                 295                 300                 


Lys Thr Gly Thr Leu Thr Lys Asn Glu Met Thr Val Thr His Ile Phe 
305                 310                 315                 320 


Thr Ser Asp Gly Leu His Ala Glu Val Thr Gly Val Gly Tyr Asn Gln 
                325                 330                 335     


Phe Gly Glu Val Ile Val Asp Gly Asp Val Val His Gly Phe Tyr Asn 
            340                 345                 350         


Pro Ala Val Ser Arg Ile Val Glu Ala Gly Cys Val Cys Asn Asp Ala 
        355                 360                 365             


Val Ile Arg Asn Asn Thr Leu Met Gly Lys Pro Thr Glu Gly Ala Leu 
    370                 375                 380                 


Ile Ala Leu Ala Met Lys Met Gly Leu Asp Gly Leu Gln Gln Asp Tyr 
385                 390                 395                 400 


Ile Arg Lys Ala Glu Tyr Pro Phe Ser Ser Glu Gln Lys Trp Met Ala 
                405                 410                 415     


Val Lys Cys Val His Arg Thr Gln Gln Asp Arg Pro Glu Ile Cys Phe 
            420                 425                 430         


Met Lys Gly Ala Tyr Glu Gln Val Ile Lys Tyr Cys Thr Thr Tyr Gln 
        435                 440                 445             


Ser Lys Gly Gln Thr Leu Thr Leu Thr Gln Gln Gln Arg Asp Val Tyr 
    450                 455                 460                 


Gln Gln Glu Lys Ala Arg Met Gly Ser Ala Gly Leu Arg Val Leu Ala 
465                 470                 475                 480 


Leu Ala Ser Gly Pro Glu Leu Gly Gln Leu Thr Phe Leu Gly Leu Val 
                485                 490                 495     


Gly Ile Ile Asp Pro Pro Arg Thr Gly Val Lys Glu Ala Val Thr Thr 
            500                 505                 510         


Leu Ile Ala Ser Gly Val Ser Ile Lys Met Ile Thr Gly Asp Ser Gln 
        515                 520                 525             


Glu Thr Ala Val Ala Ile Ala Ser Arg Leu Gly Leu Tyr Ser Lys Thr 
    530                 535                 540                 


Ser Gln Ser Val Ser Gly Glu Glu Ile Asp Ala Met Asp Val Gln Gln 
545                 550                 555                 560 


Leu Ser Gln Ile Val Pro Lys Val Ala Val Phe Tyr Arg Ala Ser Pro 
                565                 570                 575     


Arg His Lys Met Lys Ile Ile Lys Ser Leu Gln Lys Asn Gly Ser Val 
            580                 585                 590         


Val Ala Met Thr Gly Asp Gly Val Asn Asp Ala Val Ala Leu Lys Ala 
        595                 600                 605             


Ala Asp Ile Gly Val Ala Met Gly Gln Thr Gly Thr Asp Val Cys Lys 
    610                 615                 620                 


Glu Ala Ala Asp Met Ile Leu Val Asp Asp Asp Phe Gln Thr Ile Met 
625                 630                 635                 640 


Ser Ala Ile Glu Glu Gly Lys Gly Ile Tyr Asn Asn Ile Lys Asn Phe 
                645                 650                 655     


Val Arg Phe Gln Leu Ser Thr Ser Ile Ala Ala Leu Thr Leu Ile Ser 
            660                 665                 670         


Leu Ala Thr Leu Met Asn Phe Pro Asn Pro Leu Asn Ala Met Gln Ile 
        675                 680                 685             


Leu Trp Ile Asn Ile Ile Met Asp Gly Pro Pro Ala Gln Ser Leu Gly 
    690                 695                 700                 


Val Glu Pro Val Asp Lys Asp Val Ile Arg Lys Pro Pro Arg Asn Trp 
705                 710                 715                 720 


Lys Asp Ser Ile Leu Thr Lys Asn Leu Ile Leu Lys Ile Leu Val Ser 
                725                 730                 735     


Ser Ile Ile Ile Val Cys Gly Thr Leu Phe Val Phe Trp Arg Glu Leu 
            740                 745                 750         


Arg Asp Asn Val Ile Thr Pro Arg Asp Thr Thr Met Thr Phe Thr Cys 
        755                 760                 765             


Phe Val Phe Phe Asp Met Phe Asn Ala Leu Ser Ser Arg Ser Gln Thr 
    770                 775                 780                 


Lys Ser Val Phe Glu Ile Gly Leu Cys Ser Asn Arg Met Phe Cys Tyr 
785                 790                 795                 800 


Ala Val Leu Gly Ser Ile Met Gly Gln Leu Leu Val Ile Tyr Phe Pro 
                805                 810                 815     


Pro Leu Gln Lys Val Phe Gln Thr Glu Ser Leu Ser Ile Leu Asp Leu 
            820                 825                 830         


Leu Phe Leu Leu Gly Leu Thr Ser Ser Val Cys Ile Val Ala Glu Ile 
        835                 840                 845             


Ile Lys Lys Val Glu Arg Ser Arg Glu Lys Ile Gln Lys His Val Ser 
    850                 855                 860                 


Ser Thr Ser Ser Ser Phe Leu Glu Val Trp Leu Trp Glu Arg Ser Gly 
865                 870                 875                 880 


Gln Gln Leu Val Glu Ile His Pro His Leu Glu Thr Gly Leu Pro Leu 
                885                 890                 895     


Thr Glu Asp Val Ser Cys Val 
            900             


<210>  40
<211>  903
<212>  PRT
<213>  Homo sapiens

<400>  40

Met Ile Pro Val Leu Thr Ser Lys Lys Ala Ser Glu Leu Pro Val Ser 
1               5                   10                  15      


Glu Val Ala Ser Ile Leu Gln Ala Asp Leu Gln Asn Gly Leu Asn Lys 
            20                  25                  30          


Cys Glu Val Ser His Arg Arg Ala Phe His Gly Trp Asn Glu Phe Asp 
        35                  40                  45              


Ile Ser Glu Asp Glu Pro Leu Trp Lys Lys Tyr Ile Ser Gln Phe Lys 
    50                  55                  60                  


Asn Pro Leu Ile Met Leu Leu Leu Ala Ser Ala Val Ile Ser Val Leu 
65                  70                  75                  80  


Met His Gln Phe Asp Asp Ala Val Ser Ile Thr Val Ala Ile Leu Ile 
                85                  90                  95      


Val Val Thr Val Ala Phe Val Gln Glu Tyr Arg Ser Glu Lys Ser Leu 
            100                 105                 110         


Glu Glu Leu Ser Lys Leu Val Pro Pro Glu Cys His Cys Val Arg Glu 
        115                 120                 125             


Gly Lys Leu Glu His Thr Leu Ala Arg Asp Leu Val Pro Gly Asp Thr 
    130                 135                 140                 


Val Cys Leu Ser Val Gly Asp Arg Val Pro Ala Asp Leu Arg Leu Phe 
145                 150                 155                 160 


Glu Ala Val Asp Leu Ser Ile Asp Glu Ser Ser Leu Thr Gly Glu Thr 
                165                 170                 175     


Thr Pro Cys Ser Lys Val Thr Ala Pro Gln Pro Ala Ala Thr Asn Gly 
            180                 185                 190         


Asp Leu Ala Ser Arg Ser Asn Ile Ala Phe Met Gly Thr Leu Val Arg 
        195                 200                 205             


Cys Gly Lys Ala Lys Gly Val Val Ile Gly Thr Gly Glu Asn Ser Glu 
    210                 215                 220                 


Phe Gly Glu Val Phe Lys Met Met Gln Ala Glu Glu Ala Pro Lys Thr 
225                 230                 235                 240 


Pro Leu Gln Lys Ser Met Asp Leu Leu Gly Lys Gln Leu Ser Phe Tyr 
                245                 250                 255     


Ser Phe Gly Ile Ile Gly Ile Ile Met Leu Val Gly Trp Leu Leu Gly 
            260                 265                 270         


Lys Asp Ile Leu Glu Met Phe Thr Ile Ser Val Ser Leu Ala Val Ala 
        275                 280                 285             


Ala Ile Pro Glu Gly Leu Pro Ile Val Val Thr Val Thr Leu Ala Leu 
    290                 295                 300                 


Gly Val Met Arg Met Val Lys Lys Arg Ala Ile Val Lys Lys Leu Pro 
305                 310                 315                 320 


Ile Val Glu Thr Leu Gly Cys Cys Asn Val Ile Cys Ser Asp Lys Thr 
                325                 330                 335     


Gly Thr Leu Thr Lys Asn Glu Met Thr Val Thr His Ile Phe Thr Ser 
            340                 345                 350         


Asp Gly Leu His Ala Glu Val Thr Gly Val Gly Tyr Asn Gln Phe Gly 
        355                 360                 365             


Glu Val Ile Val Asp Gly Asp Val Val His Gly Phe Tyr Asn Pro Ala 
    370                 375                 380                 


Val Ser Arg Ile Val Glu Ala Gly Cys Val Cys Asn Asp Ala Val Ile 
385                 390                 395                 400 


Arg Asn Asn Thr Leu Met Gly Lys Pro Thr Glu Gly Ala Leu Ile Ala 
                405                 410                 415     


Leu Ala Met Lys Met Gly Leu Asp Gly Leu Gln Gln Asp Tyr Ile Arg 
            420                 425                 430         


Lys Ala Glu Tyr Pro Phe Ser Ser Glu Gln Lys Trp Met Ala Val Lys 
        435                 440                 445             


Cys Val His Arg Thr Gln Gln Asp Arg Pro Glu Ile Cys Phe Met Lys 
    450                 455                 460                 


Gly Ala Tyr Glu Gln Val Ile Lys Tyr Cys Thr Thr Tyr Gln Ser Lys 
465                 470                 475                 480 


Gly Gln Thr Leu Thr Leu Thr Gln Gln Gln Arg Asp Val Tyr Gln Gln 
                485                 490                 495     


Glu Lys Ala Arg Met Gly Ser Ala Gly Leu Arg Val Leu Ala Leu Ala 
            500                 505                 510         


Ser Gly Pro Glu Leu Gly Gln Leu Thr Phe Leu Gly Leu Val Gly Ile 
        515                 520                 525             


Ile Asp Pro Pro Arg Thr Gly Val Lys Glu Ala Val Thr Thr Leu Ile 
    530                 535                 540                 


Ala Ser Gly Val Ser Ile Lys Met Ile Thr Gly Asp Ser Gln Glu Thr 
545                 550                 555                 560 


Ala Val Ala Ile Ala Ser Arg Leu Gly Leu Tyr Ser Lys Thr Ser Gln 
                565                 570                 575     


Ser Val Ser Gly Glu Glu Ile Asp Ala Met Asp Val Gln Gln Leu Ser 
            580                 585                 590         


Gln Ile Val Pro Lys Val Ala Val Phe Tyr Arg Ala Ser Pro Arg His 
        595                 600                 605             


Lys Met Lys Ile Ile Lys Ser Leu Gln Lys Asn Gly Ser Val Val Ala 
    610                 615                 620                 


Met Thr Gly Asp Gly Val Asn Asp Ala Val Ala Leu Lys Ala Ala Asp 
625                 630                 635                 640 


Ile Gly Val Ala Met Gly Gln Thr Gly Thr Asp Val Cys Lys Glu Ala 
                645                 650                 655     


Ala Asp Met Ile Leu Val Asp Asp Asp Phe Gln Thr Ile Met Ser Ala 
            660                 665                 670         


Ile Glu Glu Gly Lys Gly Ile Tyr Asn Asn Ile Lys Asn Phe Val Arg 
        675                 680                 685             


Phe Gln Leu Ser Thr Ser Ile Ala Ala Leu Thr Leu Ile Ser Leu Ala 
    690                 695                 700                 


Thr Leu Met Asn Phe Pro Asn Pro Leu Asn Ala Met Gln Ile Leu Trp 
705                 710                 715                 720 


Ile Asn Ile Ile Met Asp Gly Pro Pro Ala Gln Ser Leu Gly Val Glu 
                725                 730                 735     


Pro Val Asp Lys Asp Val Ile Arg Lys Pro Pro Arg Asn Trp Lys Asp 
            740                 745                 750         


Ser Ile Leu Thr Lys Asn Leu Ile Leu Lys Ile Leu Val Ser Ser Ile 
        755                 760                 765             


Ile Ile Val Cys Gly Thr Leu Phe Val Phe Trp Arg Glu Leu Arg Asp 
    770                 775                 780                 


Asn Val Ile Thr Pro Arg Asp Thr Thr Met Thr Phe Thr Cys Phe Val 
785                 790                 795                 800 


Phe Phe Asp Met Phe Asn Ala Leu Ser Ser Arg Ser Gln Thr Lys Ser 
                805                 810                 815     


Val Phe Glu Ile Gly Leu Cys Ser Asn Arg Met Phe Cys Tyr Ala Val 
            820                 825                 830         


Leu Gly Ser Ile Met Gly Gln Leu Leu Val Ile Tyr Phe Pro Pro Leu 
        835                 840                 845             


Gln Lys Val Phe Gln Thr Glu Ser Leu Ser Ile Leu Asp Leu Leu Phe 
    850                 855                 860                 


Leu Leu Gly Leu Thr Ser Ser Val Cys Ile Val Ala Glu Ile Ile Lys 
865                 870                 875                 880 


Lys Val Glu Arg Ser Arg Glu Lys Ile Gln Lys His Val Ser Ser Thr 
                885                 890                 895     


Ser Ser Ser Phe Leu Glu Val 
            900             


<210>  41
<211>  120
<212>  PRT
<213>  Homo sapiens

<400>  41

Met Lys Val Ala Arg Phe Gln Lys Ile Pro Asn Gly Glu Asn Glu Thr 
1               5                   10                  15      


Met Ile Pro Val Leu Thr Ser Lys Lys Ala Ser Glu Leu Pro Val Ser 
            20                  25                  30          


Glu Val Ala Ser Ile Leu Gln Ala Asp Leu Gln Asn Gly Leu Asn Lys 
        35                  40                  45              


Cys Glu Val Ser His Arg Arg Ala Phe His Gly Trp Asn Glu Phe Asp 
    50                  55                  60                  


Ile Ser Glu Asp Glu Pro Leu Trp Lys Lys Tyr Ile Ser Gln Phe Lys 
65                  70                  75                  80  


Asn Pro Leu Ile Met Leu Leu Leu Ala Ser Ala Val Ile Ser Val Leu 
                85                  90                  95      


Met His Gln Phe Asp Asp Ala Val Ser Ile Thr Val Ala Ile Leu Ile 
            100                 105                 110         


Val Val Thr Val Ala Phe Val Gln 
        115                 120 


<210>  42
<211>  953
<212>  PRT
<213>  Homo sapiens

<400>  42

Met Asp Ser Leu Leu Pro Pro Ser Arg Phe Ser Tyr Phe Lys Lys Tyr 
1               5                   10                  15      


Pro Leu His Ala Ile Arg Arg Tyr Leu Ser Thr Leu Arg Asn Gln Arg 
            20                  25                  30          


Ala Glu Glu Gln Val Ala Arg Phe Gln Lys Ile Pro Asn Gly Glu Asn 
        35                  40                  45              


Glu Thr Met Ile Pro Val Leu Thr Ser Lys Lys Ala Ser Glu Leu Pro 
    50                  55                  60                  


Val Ser Glu Val Ala Ser Ile Leu Gln Ala Asp Leu Gln Asn Gly Leu 
65                  70                  75                  80  


Asn Lys Cys Glu Val Ser His Arg Arg Ala Phe His Gly Trp Asn Glu 
                85                  90                  95      


Phe Asp Ile Ser Glu Asp Glu Pro Leu Trp Lys Lys Tyr Ile Ser Gln 
            100                 105                 110         


Phe Lys Asn Pro Leu Ile Met Leu Leu Leu Ala Ser Ala Val Ile Ser 
        115                 120                 125             


Val Leu Met His Gln Phe Asp Asp Ala Val Ser Ile Thr Val Ala Ile 
    130                 135                 140                 


Leu Ile Val Val Thr Val Ala Phe Val Gln Glu Tyr Arg Ser Glu Lys 
145                 150                 155                 160 


Ser Leu Glu Glu Leu Ser Lys Leu Val Pro Pro Glu Cys His Cys Val 
                165                 170                 175     


Arg Glu Gly Lys Leu Glu His Thr Leu Ala Arg Asp Leu Val Pro Gly 
            180                 185                 190         


Asp Thr Val Cys Leu Ser Val Gly Asp Arg Val Pro Ala Asp Leu Arg 
        195                 200                 205             


Leu Phe Glu Ala Val Asp Leu Ser Ile Asp Glu Ser Ser Leu Thr Gly 
    210                 215                 220                 


Glu Thr Thr Pro Cys Ser Lys Val Thr Ala Pro Gln Pro Ala Ala Thr 
225                 230                 235                 240 


Asn Gly Asp Leu Ala Ser Arg Ser Asn Ile Ala Phe Met Gly Thr Leu 
                245                 250                 255     


Val Arg Cys Gly Lys Ala Lys Gly Val Val Ile Gly Thr Gly Glu Asn 
            260                 265                 270         


Ser Glu Phe Gly Glu Val Phe Lys Met Met Gln Ala Glu Glu Ala Pro 
        275                 280                 285             


Lys Thr Pro Leu Gln Lys Ser Met Asp Leu Leu Gly Lys Gln Leu Ser 
    290                 295                 300                 


Phe Tyr Ser Phe Gly Ile Ile Gly Ile Ile Met Leu Val Gly Trp Leu 
305                 310                 315                 320 


Leu Gly Lys Asp Ile Leu Glu Met Phe Thr Ile Ser Val Ser Leu Ala 
                325                 330                 335     


Val Ala Ala Ile Pro Glu Gly Leu Pro Ile Val Val Thr Val Thr Leu 
            340                 345                 350         


Ala Leu Gly Val Met Arg Met Val Lys Lys Arg Ala Ile Val Lys Lys 
        355                 360                 365             


Leu Pro Ile Val Glu Thr Leu Gly Cys Cys Asn Val Ile Cys Ser Asp 
    370                 375                 380                 


Lys Thr Gly Thr Leu Thr Lys Asn Glu Met Thr Val Thr His Ile Phe 
385                 390                 395                 400 


Thr Ser Asp Gly Leu His Ala Glu Val Thr Gly Val Gly Tyr Asn Gln 
                405                 410                 415     


Phe Gly Glu Val Ile Val Asp Gly Asp Val Val His Gly Phe Tyr Asn 
            420                 425                 430         


Pro Ala Val Ser Arg Ile Val Glu Ala Gly Cys Val Cys Asn Asp Ala 
        435                 440                 445             


Val Ile Arg Asn Asn Thr Leu Met Gly Lys Pro Thr Glu Gly Ala Leu 
    450                 455                 460                 


Ile Ala Leu Ala Met Lys Met Gly Leu Asp Gly Leu Gln Gln Asp Tyr 
465                 470                 475                 480 


Ile Arg Lys Ala Glu Tyr Pro Phe Ser Ser Glu Gln Lys Trp Met Ala 
                485                 490                 495     


Val Lys Cys Val His Arg Thr Gln Gln Asp Arg Pro Glu Ile Cys Phe 
            500                 505                 510         


Met Lys Gly Ala Tyr Glu Gln Val Ile Lys Tyr Cys Thr Thr Tyr Gln 
        515                 520                 525             


Ser Lys Gly Gln Thr Leu Thr Leu Thr Gln Gln Gln Arg Asp Val Tyr 
    530                 535                 540                 


Gln Gln Glu Lys Ala Arg Met Gly Ser Ala Gly Leu Arg Val Leu Ala 
545                 550                 555                 560 


Leu Ala Ser Gly Pro Glu Leu Gly Gln Leu Thr Phe Leu Gly Leu Val 
                565                 570                 575     


Gly Ile Ile Asp Pro Pro Arg Thr Gly Val Lys Glu Ala Val Thr Thr 
            580                 585                 590         


Leu Ile Ala Ser Gly Val Ser Ile Lys Met Ile Thr Gly Asp Ser Gln 
        595                 600                 605             


Glu Thr Ala Val Ala Ile Ala Ser Arg Leu Gly Leu Tyr Ser Lys Thr 
    610                 615                 620                 


Ser Gln Ser Val Ser Gly Glu Glu Ile Asp Ala Met Asp Val Gln Gln 
625                 630                 635                 640 


Leu Ser Gln Ile Val Pro Lys Val Ala Val Phe Tyr Arg Ala Ser Pro 
                645                 650                 655     


Arg His Lys Met Lys Ile Ile Lys Ser Leu Gln Lys Asn Gly Ser Val 
            660                 665                 670         


Val Ala Met Thr Gly Asp Gly Val Asn Asp Ala Val Ala Leu Lys Ala 
        675                 680                 685             


Ala Asp Ile Gly Val Ala Met Gly Gln Thr Gly Thr Asp Val Cys Lys 
    690                 695                 700                 


Glu Ala Ala Asp Met Ile Leu Val Asp Asp Asp Phe Gln Thr Ile Met 
705                 710                 715                 720 


Ser Ala Ile Glu Glu Gly Lys Gly Ile Tyr Asn Asn Ile Lys Asn Phe 
                725                 730                 735     


Val Arg Phe Gln Leu Ser Thr Ser Ile Ala Ala Leu Thr Leu Ile Ser 
            740                 745                 750         


Leu Ala Thr Leu Met Asn Phe Pro Asn Pro Leu Asn Ala Met Gln Ile 
        755                 760                 765             


Leu Trp Ile Asn Ile Ile Met Asp Gly Pro Pro Ala Gln Ser Leu Gly 
    770                 775                 780                 


Val Glu Pro Val Asp Lys Asp Val Ile Arg Lys Pro Pro Arg Asn Trp 
785                 790                 795                 800 


Lys Asp Ser Ile Leu Thr Lys Asn Leu Ile Leu Lys Ile Leu Val Ser 
                805                 810                 815     


Ser Ile Ile Ile Val Cys Gly Thr Leu Phe Val Phe Trp Arg Glu Leu 
            820                 825                 830         


Arg Asp Asn Val Ile Thr Pro Arg Asp Thr Thr Met Thr Phe Thr Cys 
        835                 840                 845             


Phe Val Phe Phe Asp Met Phe Asn Ala Leu Ser Ser Arg Ser Gln Thr 
    850                 855                 860                 


Lys Ser Val Phe Glu Ile Gly Leu Cys Ser Asn Arg Met Phe Cys Tyr 
865                 870                 875                 880 


Ala Val Leu Gly Ser Ile Met Gly Gln Leu Leu Val Ile Tyr Phe Pro 
                885                 890                 895     


Pro Leu Gln Lys Val Phe Gln Thr Glu Ser Leu Ser Ile Leu Asp Leu 
            900                 905                 910         


Leu Phe Leu Leu Gly Leu Thr Ser Ser Val Cys Ile Val Ala Glu Ile 
        915                 920                 925             


Ile Lys Lys Val Glu Arg Ser Arg Glu Lys Ile Gln Lys His Val Ser 
    930                 935                 940                 


Ser Thr Ser Ser Ser Phe Leu Glu Val 
945                 950             


<210>  43
<211>  50
<212>  PRT
<213>  Homo sapiens

<400>  43

Leu Val Asp Asp Asp Phe Gln Thr Ile Met Ser Ala Ile Glu Glu Gly 
1               5                   10                  15      


Lys Gly Ile Tyr Asn Asn Ile Lys Asn Phe Val Arg Phe Gln Leu Ser 
            20                  25                  30          


Thr Phe Cys Gly Ser Ile Leu Leu Trp Met Asp Pro Gln Leu Arg Ala 
        35                  40                  45              


Leu Glu 
    50  


<210>  44
<211>  973
<212>  PRT
<213>  Homo sapiens

<400>  44

Met Asp Ser Leu Leu Pro Pro Ser Arg Phe Ser Tyr Phe Lys Lys Tyr 
1               5                   10                  15      


Pro Leu His Ala Ile Arg Arg Tyr Leu Ser Thr Leu Arg Asn Gln Arg 
            20                  25                  30          


Ala Glu Glu Gln Val Ala Arg Phe Gln Lys Ile Pro Asn Gly Glu Asn 
        35                  40                  45              


Glu Thr Met Ile Pro Val Leu Thr Ser Lys Lys Ala Ser Glu Leu Pro 
    50                  55                  60                  


Val Ser Glu Val Ala Ser Ile Leu Gln Ala Asp Leu Gln Asn Gly Leu 
65                  70                  75                  80  


Asn Lys Cys Glu Val Ser His Arg Arg Ala Phe His Gly Trp Asn Glu 
                85                  90                  95      


Phe Asp Ile Ser Glu Asp Glu Pro Leu Trp Lys Lys Tyr Ile Ser Gln 
            100                 105                 110         


Phe Lys Asn Pro Leu Ile Met Leu Leu Leu Ala Ser Ala Val Ile Ser 
        115                 120                 125             


Val Leu Met His Gln Phe Asp Asp Ala Val Ser Ile Thr Val Ala Ile 
    130                 135                 140                 


Leu Ile Val Val Thr Val Ala Phe Val Gln Glu Tyr Arg Ser Glu Lys 
145                 150                 155                 160 


Ser Leu Glu Glu Leu Ser Lys Leu Val Pro Pro Glu Cys His Cys Val 
                165                 170                 175     


Arg Glu Gly Lys Leu Glu His Thr Leu Ala Arg Asp Leu Val Pro Gly 
            180                 185                 190         


Asp Thr Val Cys Leu Ser Val Gly Asp Arg Val Pro Ala Asp Leu Arg 
        195                 200                 205             


Leu Phe Glu Ala Val Asp Leu Ser Ile Asp Glu Ser Ser Leu Thr Gly 
    210                 215                 220                 


Glu Thr Thr Pro Cys Ser Lys Val Thr Ala Pro Gln Pro Ala Ala Thr 
225                 230                 235                 240 


Asn Gly Asp Leu Ala Ser Arg Ser Asn Ile Ala Phe Met Gly Thr Leu 
                245                 250                 255     


Val Arg Cys Gly Lys Ala Lys Gly Val Val Ile Gly Thr Gly Glu Asn 
            260                 265                 270         


Ser Glu Phe Gly Glu Val Phe Lys Met Met Gln Ala Glu Glu Ala Pro 
        275                 280                 285             


Lys Thr Pro Leu Gln Lys Ser Met Asp Leu Leu Gly Lys Gln Leu Ser 
    290                 295                 300                 


Phe Tyr Ser Phe Gly Ile Ile Gly Ile Ile Met Leu Val Gly Trp Leu 
305                 310                 315                 320 


Leu Gly Lys Asp Ile Leu Glu Met Phe Thr Ile Ser Val Ser Leu Ala 
                325                 330                 335     


Val Ala Ala Ile Pro Glu Gly Leu Pro Ile Val Val Thr Val Thr Leu 
            340                 345                 350         


Ala Leu Gly Val Met Arg Met Val Lys Lys Arg Ala Ile Val Lys Lys 
        355                 360                 365             


Leu Pro Ile Val Glu Thr Leu Gly Cys Cys Asn Val Ile Cys Ser Asp 
    370                 375                 380                 


Lys Thr Gly Thr Leu Thr Lys Asn Glu Met Thr Val Thr His Ile Phe 
385                 390                 395                 400 


Thr Ser Asp Gly Leu His Ala Glu Val Thr Gly Val Gly Tyr Asn Gln 
                405                 410                 415     


Phe Gly Glu Val Ile Val Asp Gly Asp Val Val His Gly Phe Tyr Asn 
            420                 425                 430         


Pro Ala Val Ser Arg Ile Val Glu Ala Gly Cys Val Cys Asn Asp Ala 
        435                 440                 445             


Val Ile Arg Asn Asn Thr Leu Met Gly Lys Pro Thr Glu Gly Ala Leu 
    450                 455                 460                 


Ile Ala Leu Ala Met Lys Met Gly Leu Asp Gly Leu Gln Gln Asp Tyr 
465                 470                 475                 480 


Ile Arg Lys Ala Glu Tyr Pro Phe Ser Ser Glu Gln Lys Trp Met Ala 
                485                 490                 495     


Val Lys Cys Val His Arg Thr Gln Gln Asp Arg Pro Glu Ile Cys Phe 
            500                 505                 510         


Met Lys Gly Ala Tyr Glu Gln Val Ile Lys Tyr Cys Thr Thr Tyr Gln 
        515                 520                 525             


Ser Lys Gly Gln Thr Leu Thr Leu Thr Gln Gln Gln Arg Asp Val Tyr 
    530                 535                 540                 


Gln Gln Glu Lys Ala Arg Met Gly Ser Ala Gly Leu Arg Val Leu Ala 
545                 550                 555                 560 


Leu Ala Ser Gly Pro Glu Leu Gly Gln Leu Thr Phe Leu Gly Leu Val 
                565                 570                 575     


Gly Ile Ile Asp Pro Pro Arg Thr Gly Val Lys Glu Ala Val Thr Thr 
            580                 585                 590         


Leu Ile Ala Ser Gly Val Ser Ile Lys Met Ile Thr Gly Asp Ser Gln 
        595                 600                 605             


Glu Thr Ala Val Ala Ile Ala Ser Arg Leu Gly Leu Tyr Ser Lys Thr 
    610                 615                 620                 


Ser Gln Ser Val Ser Gly Glu Glu Ile Asp Ala Met Asp Val Gln Gln 
625                 630                 635                 640 


Leu Ser Gln Ile Val Pro Lys Val Ala Val Phe Tyr Arg Ala Ser Pro 
                645                 650                 655     


Arg His Lys Met Lys Ile Ile Lys Ser Leu Gln Lys Asn Gly Ser Val 
            660                 665                 670         


Val Ala Met Thr Gly Asp Gly Val Asn Asp Ala Val Ala Leu Lys Ala 
        675                 680                 685             


Ala Asp Ile Gly Val Ala Met Gly Gln Thr Gly Thr Asp Val Cys Lys 
    690                 695                 700                 


Glu Ala Ala Asp Met Ile Leu Val Asp Asp Asp Phe Gln Thr Ile Met 
705                 710                 715                 720 


Ser Ala Ile Glu Glu Gly Lys Gly Ile Tyr Asn Asn Ile Lys Asn Phe 
                725                 730                 735     


Val Arg Phe Gln Leu Ser Thr Ser Ile Ala Ala Leu Thr Leu Ile Ser 
            740                 745                 750         


Leu Ala Thr Leu Met Asn Phe Pro Asn Pro Leu Asn Ala Met Gln Ile 
        755                 760                 765             


Leu Trp Ile Asn Ile Ile Met Asp Gly Pro Pro Ala Gln Ser Leu Gly 
    770                 775                 780                 


Val Glu Pro Val Asp Lys Asp Val Ile Arg Lys Pro Pro Arg Asn Trp 
785                 790                 795                 800 


Lys Asp Ser Ile Leu Thr Lys Asn Leu Ile Leu Lys Ile Leu Val Ser 
                805                 810                 815     


Ser Ile Ile Ile Val Cys Gly Thr Leu Phe Val Phe Trp Arg Glu Leu 
            820                 825                 830         


Arg Asp Asn Val Ile Thr Pro Arg Asp Thr Thr Met Thr Phe Thr Cys 
        835                 840                 845             


Phe Val Phe Phe Asp Met Phe Asn Ala Leu Ser Ser Arg Ser Gln Thr 
    850                 855                 860                 


Lys Ser Val Phe Glu Ile Gly Leu Cys Ser Asn Arg Met Phe Cys Tyr 
865                 870                 875                 880 


Ala Val Leu Gly Ser Ile Met Gly Gln Leu Leu Val Ile Tyr Phe Pro 
                885                 890                 895     


Pro Leu Gln Lys Val Phe Gln Thr Glu Ser Leu Ser Ile Leu Asp Leu 
            900                 905                 910         


Leu Phe Leu Leu Gly Leu Thr Ser Ser Val Cys Ile Val Ala Glu Ile 
        915                 920                 925             


Ile Lys Lys Val Glu Arg Ser Arg Glu Lys Ile Gln Lys His Val Trp 
    930                 935                 940                 


Leu Trp Glu Arg Ser Gly Gln Gln Leu Val Glu Ile His Pro His Leu 
945                 950                 955                 960 


Glu Thr Gly Leu Pro Leu Thr Glu Asp Val Ser Cys Val 
                965                 970             


<210>  45
<211>  82
<212>  PRT
<213>  Homo sapiens

<400>  45

Met Ile Pro Val Leu Thr Ser Lys Lys Ala Ser Glu Leu Pro Val Ser 
1               5                   10                  15      


Glu Val Ala Ser Ile Leu Gln Ala Asp Leu Gln Asn Gly Leu Asn Lys 
            20                  25                  30          


Cys Glu Val Ser His Arg Arg Ala Phe His Gly Trp Asn Glu Phe Asp 
        35                  40                  45              


Ile Ser Glu Asp Glu Pro Leu Trp Lys Lys Tyr Ile Ser Gln Phe Lys 
    50                  55                  60                  


Asn Pro Leu Ile Met Leu Leu Leu Ala Ser Ala Val Ile Ser Val Leu 
65                  70                  75                  80  


Met His 
        


<210>  46
<211>  919
<212>  PRT
<213>  Homo sapiens

<400>  46

Met Lys Val Ala Arg Phe Gln Lys Ile Pro Asn Gly Glu Asn Glu Thr 
1               5                   10                  15      


Met Ile Pro Val Leu Thr Ser Lys Lys Ala Ser Glu Leu Pro Val Ser 
            20                  25                  30          


Glu Val Ala Ser Ile Leu Gln Ala Asp Leu Gln Asn Gly Leu Asn Lys 
        35                  40                  45              


Cys Glu Val Ser His Arg Arg Ala Phe His Gly Trp Asn Glu Phe Asp 
    50                  55                  60                  


Ile Ser Glu Asp Glu Pro Leu Trp Lys Lys Tyr Ile Ser Gln Phe Lys 
65                  70                  75                  80  


Asn Pro Leu Ile Met Leu Leu Leu Ala Ser Ala Val Ile Ser Val Leu 
                85                  90                  95      


Met His Gln Phe Asp Asp Ala Val Ser Ile Thr Val Ala Ile Leu Ile 
            100                 105                 110         


Val Val Thr Val Ala Phe Val Gln Glu Tyr Arg Ser Glu Lys Ser Leu 
        115                 120                 125             


Glu Glu Leu Ser Lys Leu Val Pro Pro Glu Cys His Cys Val Arg Glu 
    130                 135                 140                 


Gly Lys Leu Glu His Thr Leu Ala Arg Asp Leu Val Pro Gly Asp Thr 
145                 150                 155                 160 


Val Cys Leu Ser Val Gly Asp Arg Val Pro Ala Asp Leu Arg Leu Phe 
                165                 170                 175     


Glu Ala Val Asp Leu Ser Ile Asp Glu Ser Ser Leu Thr Gly Glu Thr 
            180                 185                 190         


Thr Pro Cys Ser Lys Val Thr Ala Pro Gln Pro Ala Ala Thr Asn Gly 
        195                 200                 205             


Asp Leu Ala Ser Arg Ser Asn Ile Ala Phe Met Gly Thr Leu Val Arg 
    210                 215                 220                 


Cys Gly Lys Ala Lys Gly Val Val Ile Gly Thr Gly Glu Asn Ser Glu 
225                 230                 235                 240 


Phe Gly Glu Val Phe Lys Met Met Gln Ala Glu Glu Ala Pro Lys Thr 
                245                 250                 255     


Pro Leu Gln Lys Ser Met Asp Leu Leu Gly Lys Gln Leu Ser Phe Tyr 
            260                 265                 270         


Ser Phe Gly Ile Ile Gly Ile Ile Met Leu Val Gly Trp Leu Leu Gly 
        275                 280                 285             


Lys Asp Ile Leu Glu Met Phe Thr Ile Ser Val Ser Leu Ala Val Ala 
    290                 295                 300                 


Ala Ile Pro Glu Gly Leu Pro Ile Val Val Thr Val Thr Leu Ala Leu 
305                 310                 315                 320 


Gly Val Met Arg Met Val Lys Lys Arg Ala Ile Val Lys Lys Leu Pro 
                325                 330                 335     


Ile Val Glu Thr Leu Gly Cys Cys Asn Val Ile Cys Ser Asp Lys Thr 
            340                 345                 350         


Gly Thr Leu Thr Lys Asn Glu Met Thr Val Thr His Ile Phe Thr Ser 
        355                 360                 365             


Asp Gly Leu His Ala Glu Val Thr Gly Val Gly Tyr Asn Gln Phe Gly 
    370                 375                 380                 


Glu Val Ile Val Asp Gly Asp Val Val His Gly Phe Tyr Asn Pro Ala 
385                 390                 395                 400 


Val Ser Arg Ile Val Glu Ala Gly Cys Val Cys Asn Asp Ala Val Ile 
                405                 410                 415     


Arg Asn Asn Thr Leu Met Gly Lys Pro Thr Glu Gly Ala Leu Ile Ala 
            420                 425                 430         


Leu Ala Met Lys Met Gly Leu Asp Gly Leu Gln Gln Asp Tyr Ile Arg 
        435                 440                 445             


Lys Ala Glu Tyr Pro Phe Ser Ser Glu Gln Lys Trp Met Ala Val Lys 
    450                 455                 460                 


Cys Val His Arg Thr Gln Gln Asp Arg Pro Glu Ile Cys Phe Met Lys 
465                 470                 475                 480 


Gly Ala Tyr Glu Gln Val Ile Lys Tyr Cys Thr Thr Tyr Gln Ser Lys 
                485                 490                 495     


Gly Gln Thr Leu Thr Leu Thr Gln Gln Gln Arg Asp Val Tyr Gln Gln 
            500                 505                 510         


Glu Lys Ala Arg Met Gly Ser Ala Gly Leu Arg Val Leu Ala Leu Ala 
        515                 520                 525             


Ser Gly Pro Glu Leu Gly Gln Leu Thr Phe Leu Gly Leu Val Gly Ile 
    530                 535                 540                 


Ile Asp Pro Pro Arg Thr Gly Val Lys Glu Ala Val Thr Thr Leu Ile 
545                 550                 555                 560 


Ala Ser Gly Val Ser Ile Lys Met Ile Thr Gly Asp Ser Gln Glu Thr 
                565                 570                 575     


Ala Val Ala Ile Ala Ser Arg Leu Gly Leu Tyr Ser Lys Thr Ser Gln 
            580                 585                 590         


Ser Val Ser Gly Glu Glu Ile Asp Ala Met Asp Val Gln Gln Leu Ser 
        595                 600                 605             


Gln Ile Val Pro Lys Val Ala Val Phe Tyr Arg Ala Ser Pro Arg His 
    610                 615                 620                 


Lys Met Lys Ile Ile Lys Ser Leu Gln Lys Asn Gly Ser Val Val Ala 
625                 630                 635                 640 


Met Thr Gly Asp Gly Val Asn Asp Ala Val Ala Leu Lys Ala Ala Asp 
                645                 650                 655     


Ile Gly Val Ala Met Gly Gln Thr Gly Thr Asp Val Cys Lys Glu Ala 
            660                 665                 670         


Ala Asp Met Ile Leu Val Asp Asp Asp Phe Gln Thr Ile Met Ser Ala 
        675                 680                 685             


Ile Glu Glu Gly Lys Gly Ile Tyr Asn Asn Ile Lys Asn Phe Val Arg 
    690                 695                 700                 


Phe Gln Leu Ser Thr Ser Ile Ala Ala Leu Thr Leu Ile Ser Leu Ala 
705                 710                 715                 720 


Thr Leu Met Asn Phe Pro Asn Pro Leu Asn Ala Met Gln Ile Leu Trp 
                725                 730                 735     


Ile Asn Ile Ile Met Asp Gly Pro Pro Ala Gln Ser Leu Gly Val Glu 
            740                 745                 750         


Pro Val Asp Lys Asp Val Ile Arg Lys Pro Pro Arg Asn Trp Lys Asp 
        755                 760                 765             


Ser Ile Leu Thr Lys Asn Leu Ile Leu Lys Ile Leu Val Ser Ser Ile 
    770                 775                 780                 


Ile Ile Val Cys Gly Thr Leu Phe Val Phe Trp Arg Glu Leu Arg Asp 
785                 790                 795                 800 


Asn Val Ile Thr Pro Arg Asp Thr Thr Met Thr Phe Thr Cys Phe Val 
                805                 810                 815     


Phe Phe Asp Met Phe Asn Ala Leu Ser Ser Arg Ser Gln Thr Lys Ser 
            820                 825                 830         


Val Phe Glu Ile Gly Leu Cys Ser Asn Arg Met Phe Cys Tyr Ala Val 
        835                 840                 845             


Leu Gly Ser Ile Met Gly Gln Leu Leu Val Ile Tyr Phe Pro Pro Leu 
    850                 855                 860                 


Gln Lys Val Phe Gln Thr Glu Ser Leu Ser Ile Leu Asp Leu Leu Phe 
865                 870                 875                 880 


Leu Leu Gly Leu Thr Ser Ser Val Cys Ile Val Ala Glu Ile Ile Lys 
                885                 890                 895     


Lys Val Glu Arg Ser Arg Glu Lys Ile Gln Lys His Val Ser Ser Thr 
            900                 905                 910         


Ser Ser Ser Phe Leu Glu Val 
        915                 


<210>  47
<211>  314
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  47

Xaa Glu Gly Ala Leu Ile Ala Leu Ala Met Lys Met Gly Leu Asp Gly 
1               5                   10                  15      


Leu Gln Gln Asp Tyr Ile Arg Lys Ala Glu Tyr Pro Phe Ser Ser Glu 
            20                  25                  30          


Gln Lys Trp Met Ala Val Lys Cys Val His Arg Thr Gln Gln Asp Arg 
        35                  40                  45              


Pro Glu Ile Cys Phe Met Lys Gly Ala Tyr Glu Gln Val Ile Lys Tyr 
    50                  55                  60                  


Cys Thr Thr Tyr Gln Ser Lys Gly Gln Thr Leu Thr Leu Thr Gln Gln 
65                  70                  75                  80  


Gln Arg Asp Val Tyr Gln Gln Glu Lys Ala Arg Met Gly Ser Ala Gly 
                85                  90                  95      


Leu Arg Ala Ser Arg Leu Gly Leu Tyr Ser Lys Thr Ser Gln Ser Val 
            100                 105                 110         


Ser Gly Glu Glu Ile Asp Ala Met Asp Val Gln Gln Leu Ser Gln Ile 
        115                 120                 125             


Val Pro Lys Val Ala Val Phe Tyr Arg Ala Ser Pro Arg His Lys Met 
    130                 135                 140                 


Lys Ile Ile Lys Ser Leu Gln Lys Asn Gly Ser Val Val Ala Met Thr 
145                 150                 155                 160 


Gly Asp Gly Val Asn Asp Ala Val Ala Leu Lys Ala Ala Asp Ile Gly 
                165                 170                 175     


Val Ala Met Gly Gln Thr Gly Thr Asp Val Cys Lys Glu Ala Ala Asp 
            180                 185                 190         


Met Ile Leu Val Asp Asp Asp Phe Gln Thr Ile Met Ser Ala Ile Glu 
        195                 200                 205             


Glu Gly Lys Gly Ile Tyr Asn Asn Ile Lys Asn Phe Val Arg Phe Gln 
    210                 215                 220                 


Leu Ser Thr Ser Ile Ala Ala Leu Thr Leu Ile Ser Leu Ala Thr Leu 
225                 230                 235                 240 


Met Asn Phe Pro Asn Pro Leu Asn Ala Met Gln Ile Leu Trp Ile Asn 
                245                 250                 255     


Ile Ile Met Asp Gly Pro Pro Ala Gln Ser Leu Gly Val Glu Pro Val 
            260                 265                 270         


Asp Lys Asp Val Ile Arg Lys Pro Pro Arg Asn Trp Lys Asp Ser Ile 
        275                 280                 285             


Leu Thr Lys Asn Leu Ile Leu Lys Ile Leu Val Ser Ser Ile Ile Ile 
    290                 295                 300                 


Val Cys Gly Thr Leu Phe Val Phe Trp Arg 
305                 310                 


<210>  48
<211>  102
<212>  PRT
<213>  Homo sapiens

<400>  48

Met Lys Val Ala Arg Phe Gln Lys Ile Pro Asn Gly Glu Asn Glu Thr 
1               5                   10                  15      


Met Ile Pro Val Leu Thr Ser Lys Lys Ala Ser Glu Leu Pro Val Ser 
            20                  25                  30          


Glu Val Ala Ser Ile Leu Gln Ala Asp Leu Gln Asn Gly Leu Asn Lys 
        35                  40                  45              


Cys Glu Val Ser His Arg Arg Ala Phe His Gly Trp Asn Glu Phe Asp 
    50                  55                  60                  


Ile Ser Glu Asp Glu Pro Leu Trp Lys Lys Tyr Ile Ser Gln Phe Lys 
65                  70                  75                  80  


Asn Pro Leu Ile Met Leu Leu Leu Ala Ser Ala Val Ile Ser Val Leu 
                85                  90                  95      


Met His Gln Phe Asp Asp 
            100         


<210>  49
<211>  919
<212>  PRT
<213>  Homo sapiens

<400>  49

Met Lys Val Ala Arg Phe Gln Lys Ile Pro Asn Gly Glu Asn Glu Thr 
1               5                   10                  15      


Met Ile Pro Val Leu Thr Ser Lys Lys Ala Ser Glu Leu Pro Val Ser 
            20                  25                  30          


Glu Val Ala Ser Ile Leu Gln Ala Asp Leu Gln Asn Gly Leu Asn Lys 
        35                  40                  45              


Cys Glu Val Ser His Arg Arg Ala Phe His Gly Trp Asn Glu Phe Asp 
    50                  55                  60                  


Ile Ser Glu Asp Glu Pro Leu Trp Lys Lys Tyr Ile Ser Gln Phe Lys 
65                  70                  75                  80  


Asn Pro Leu Ile Met Leu Leu Leu Ala Ser Ala Val Ile Ser Val Leu 
                85                  90                  95      


Met His Gln Phe Asp Asp Ala Val Ser Ile Thr Val Ala Ile Leu Ile 
            100                 105                 110         


Val Val Thr Val Ala Phe Val Gln Glu Tyr Arg Ser Glu Lys Ser Leu 
        115                 120                 125             


Glu Glu Leu Ser Lys Leu Val Pro Pro Glu Cys His Cys Val Arg Glu 
    130                 135                 140                 


Gly Lys Leu Glu His Thr Leu Ala Arg Asp Leu Val Pro Gly Asp Thr 
145                 150                 155                 160 


Val Cys Leu Ser Val Gly Asp Arg Val Pro Ala Asp Leu Arg Leu Phe 
                165                 170                 175     


Glu Ala Val Asp Leu Ser Ile Asp Glu Ser Ser Leu Thr Gly Glu Thr 
            180                 185                 190         


Thr Pro Cys Ser Lys Val Thr Ala Pro Gln Pro Ala Ala Thr Asn Gly 
        195                 200                 205             


Asp Leu Ala Ser Arg Ser Asn Ile Ala Phe Met Gly Thr Leu Val Arg 
    210                 215                 220                 


Cys Gly Lys Ala Lys Gly Val Val Ile Gly Thr Gly Glu Asn Ser Glu 
225                 230                 235                 240 


Phe Gly Glu Val Phe Lys Met Met Gln Ala Glu Glu Ala Pro Lys Thr 
                245                 250                 255     


Pro Leu Gln Lys Ser Met Asp Leu Leu Gly Lys Gln Leu Ser Phe Tyr 
            260                 265                 270         


Ser Phe Gly Ile Ile Gly Ile Ile Met Leu Val Gly Trp Leu Leu Gly 
        275                 280                 285             


Lys Asp Ile Leu Glu Met Phe Thr Ile Ser Val Ser Leu Ala Val Ala 
    290                 295                 300                 


Ala Ile Pro Glu Gly Leu Pro Ile Val Val Thr Val Thr Leu Ala Leu 
305                 310                 315                 320 


Gly Val Met Arg Met Val Lys Lys Arg Ala Ile Val Lys Lys Leu Pro 
                325                 330                 335     


Ile Val Glu Thr Leu Gly Cys Cys Asn Val Ile Cys Ser Asp Lys Thr 
            340                 345                 350         


Gly Thr Leu Thr Lys Asn Glu Met Thr Val Thr His Ile Phe Thr Ser 
        355                 360                 365             


Asp Gly Leu His Ala Glu Val Thr Gly Val Gly Tyr Asn Gln Phe Gly 
    370                 375                 380                 


Glu Val Ile Val Asp Gly Asp Val Val His Gly Phe Tyr Asn Pro Ala 
385                 390                 395                 400 


Val Ser Arg Ile Val Glu Ala Gly Cys Val Cys Asn Asp Ala Val Ile 
                405                 410                 415     


Arg Asn Asn Thr Leu Met Gly Lys Pro Thr Glu Gly Ala Leu Ile Ala 
            420                 425                 430         


Leu Ala Met Lys Met Gly Leu Asp Gly Leu Gln Gln Asp Tyr Ile Arg 
        435                 440                 445             


Lys Ala Glu Tyr Pro Phe Ser Ser Glu Gln Lys Trp Met Ala Val Lys 
    450                 455                 460                 


Cys Val His Arg Thr Gln Gln Asp Arg Pro Glu Ile Cys Phe Met Lys 
465                 470                 475                 480 


Gly Ala Tyr Glu Gln Val Ile Lys Tyr Cys Thr Thr Tyr Gln Ser Lys 
                485                 490                 495     


Gly Gln Thr Leu Thr Leu Thr Gln Gln Gln Arg Asp Val Tyr Gln Gln 
            500                 505                 510         


Glu Lys Ala Arg Met Gly Ser Ala Gly Leu Arg Val Leu Ala Leu Ala 
        515                 520                 525             


Ser Gly Pro Glu Leu Gly Gln Leu Thr Phe Leu Gly Leu Val Gly Ile 
    530                 535                 540                 


Ile Asp Pro Pro Arg Thr Gly Val Lys Glu Ala Val Thr Thr Leu Ile 
545                 550                 555                 560 


Ala Ser Gly Val Ser Ile Lys Met Ile Thr Gly Asp Ser Gln Glu Thr 
                565                 570                 575     


Ala Val Ala Ile Ala Ser Arg Leu Gly Leu Tyr Ser Lys Thr Ser Gln 
            580                 585                 590         


Ser Val Ser Gly Glu Glu Ile Asp Ala Met Asp Val Gln Gln Leu Ser 
        595                 600                 605             


Gln Ile Val Pro Lys Val Ala Val Phe Tyr Arg Ala Ser Pro Arg His 
    610                 615                 620                 


Lys Met Lys Ile Ile Lys Ser Leu Gln Lys Asn Gly Ser Val Val Ala 
625                 630                 635                 640 


Met Thr Gly Asp Gly Val Asn Asp Ala Val Ala Leu Lys Ala Ala Asp 
                645                 650                 655     


Ile Gly Val Ala Met Gly Gln Thr Gly Thr Asp Val Cys Lys Glu Ala 
            660                 665                 670         


Ala Asp Met Ile Leu Val Asp Asp Asp Phe Gln Thr Ile Met Ser Ala 
        675                 680                 685             


Ile Glu Glu Gly Lys Gly Ile Tyr Asn Asn Ile Lys Asn Phe Val Arg 
    690                 695                 700                 


Phe Gln Leu Ser Thr Ser Ile Ala Ala Leu Thr Leu Ile Ser Leu Ala 
705                 710                 715                 720 


Thr Leu Met Asn Phe Pro Asn Pro Leu Asn Ala Met Gln Ile Leu Trp 
                725                 730                 735     


Ile Asn Ile Ile Met Asp Gly Pro Pro Ala Gln Ser Leu Gly Val Glu 
            740                 745                 750         


Pro Val Asp Lys Asp Val Ile Arg Lys Pro Pro Arg Asn Trp Lys Asp 
        755                 760                 765             


Ser Ile Leu Thr Lys Asn Leu Ile Leu Lys Ile Leu Val Ser Ser Ile 
    770                 775                 780                 


Ile Ile Val Cys Gly Thr Leu Phe Val Phe Trp Arg Glu Leu Arg Asp 
785                 790                 795                 800 


Asn Val Ile Thr Pro Arg Asp Thr Thr Met Thr Phe Thr Cys Phe Val 
                805                 810                 815     


Phe Phe Asp Met Phe Asn Ala Leu Ser Ser Arg Ser Gln Thr Lys Ser 
            820                 825                 830         


Val Phe Glu Ile Gly Leu Cys Ser Asn Arg Met Phe Cys Tyr Ala Val 
        835                 840                 845             


Leu Gly Ser Ile Met Gly Gln Leu Leu Val Ile Tyr Phe Pro Pro Leu 
    850                 855                 860                 


Gln Lys Val Phe Gln Thr Glu Ser Leu Ser Ile Leu Asp Leu Leu Phe 
865                 870                 875                 880 


Leu Leu Gly Leu Thr Ser Ser Val Cys Ile Val Ala Glu Ile Ile Lys 
                885                 890                 895     


Lys Val Glu Arg Ser Arg Glu Lys Ile Gln Lys His Val Ser Ser Thr 
            900                 905                 910         


Ser Ser Ser Phe Leu Glu Val 
        915                 


<210>  50
<211>  923
<212>  PRT
<213>  Homo sapiens

<400>  50

Met Ile Pro Val Leu Thr Ser Lys Lys Ala Ser Glu Leu Pro Val Ser 
1               5                   10                  15      


Glu Val Ala Ser Ile Leu Gln Ala Asp Leu Gln Asn Gly Leu Asn Lys 
            20                  25                  30          


Cys Glu Val Ser His Arg Arg Ala Phe His Gly Trp Asn Glu Phe Asp 
        35                  40                  45              


Ile Ser Glu Asp Glu Pro Leu Trp Lys Lys Tyr Ile Ser Gln Phe Lys 
    50                  55                  60                  


Asn Pro Leu Ile Met Leu Leu Leu Ala Ser Ala Val Ile Ser Val Leu 
65                  70                  75                  80  


Met His Gln Phe Asp Asp Ala Val Ser Ile Thr Val Ala Ile Leu Ile 
                85                  90                  95      


Val Val Thr Val Ala Phe Val Gln Glu Tyr Arg Ser Glu Lys Ser Leu 
            100                 105                 110         


Glu Glu Leu Ser Lys Leu Val Pro Pro Glu Cys His Cys Val Arg Glu 
        115                 120                 125             


Gly Lys Leu Glu His Thr Leu Ala Arg Asp Leu Val Pro Gly Asp Thr 
    130                 135                 140                 


Val Cys Leu Ser Val Gly Asp Arg Val Pro Ala Asp Leu Arg Leu Phe 
145                 150                 155                 160 


Glu Ala Val Asp Leu Ser Ile Asp Glu Ser Ser Leu Thr Gly Glu Thr 
                165                 170                 175     


Thr Pro Cys Ser Lys Val Thr Ala Pro Gln Pro Ala Ala Thr Asn Gly 
            180                 185                 190         


Asp Leu Ala Ser Arg Ser Asn Ile Ala Phe Met Gly Thr Leu Val Arg 
        195                 200                 205             


Cys Gly Lys Ala Lys Gly Val Val Ile Gly Thr Gly Glu Asn Ser Glu 
    210                 215                 220                 


Phe Gly Glu Val Phe Lys Met Met Gln Ala Glu Glu Ala Pro Lys Thr 
225                 230                 235                 240 


Pro Leu Gln Lys Ser Met Asp Leu Leu Gly Lys Gln Leu Ser Phe Tyr 
                245                 250                 255     


Ser Phe Gly Ile Ile Gly Ile Ile Met Leu Val Gly Trp Leu Leu Gly 
            260                 265                 270         


Lys Asp Ile Leu Glu Met Phe Thr Ile Ser Val Ser Leu Ala Val Ala 
        275                 280                 285             


Ala Ile Pro Glu Gly Leu Pro Ile Val Val Thr Val Thr Leu Ala Leu 
    290                 295                 300                 


Gly Val Met Arg Met Val Lys Lys Arg Ala Ile Val Lys Lys Leu Pro 
305                 310                 315                 320 


Ile Val Glu Thr Leu Gly Cys Cys Asn Val Ile Cys Ser Asp Lys Thr 
                325                 330                 335     


Gly Thr Leu Thr Lys Asn Glu Met Thr Val Thr His Ile Phe Thr Ser 
            340                 345                 350         


Asp Gly Leu His Ala Glu Val Thr Gly Val Gly Tyr Asn Gln Phe Gly 
        355                 360                 365             


Glu Val Ile Val Asp Gly Asp Val Val His Gly Phe Tyr Asn Pro Ala 
    370                 375                 380                 


Val Ser Arg Ile Val Glu Ala Gly Cys Val Cys Asn Asp Ala Val Ile 
385                 390                 395                 400 


Arg Asn Asn Thr Leu Met Gly Lys Pro Thr Glu Gly Ala Leu Ile Ala 
                405                 410                 415     


Leu Ala Met Lys Met Gly Leu Asp Gly Leu Gln Gln Asp Tyr Ile Arg 
            420                 425                 430         


Lys Ala Glu Tyr Pro Phe Ser Ser Glu Gln Lys Trp Met Ala Val Lys 
        435                 440                 445             


Cys Val His Arg Thr Gln Gln Asp Arg Pro Glu Ile Cys Phe Met Lys 
    450                 455                 460                 


Gly Ala Tyr Glu Gln Val Ile Lys Tyr Cys Thr Thr Tyr Gln Ser Lys 
465                 470                 475                 480 


Gly Gln Thr Leu Thr Leu Thr Gln Gln Gln Arg Asp Val Tyr Gln Gln 
                485                 490                 495     


Glu Lys Ala Arg Met Gly Ser Ala Gly Leu Arg Val Leu Ala Leu Ala 
            500                 505                 510         


Ser Gly Pro Glu Leu Gly Gln Leu Thr Phe Leu Gly Leu Val Gly Ile 
        515                 520                 525             


Ile Asp Pro Pro Arg Thr Gly Val Lys Glu Ala Val Thr Thr Leu Ile 
    530                 535                 540                 


Ala Ser Gly Val Ser Ile Lys Met Ile Thr Gly Asp Ser Gln Glu Thr 
545                 550                 555                 560 


Ala Val Ala Ile Ala Ser Arg Leu Gly Leu Tyr Ser Lys Thr Ser Gln 
                565                 570                 575     


Ser Val Ser Gly Glu Glu Ile Asp Ala Met Asp Val Gln Gln Leu Ser 
            580                 585                 590         


Gln Ile Val Pro Lys Val Ala Val Phe Tyr Arg Ala Ser Pro Arg His 
        595                 600                 605             


Lys Met Lys Ile Ile Lys Ser Leu Gln Lys Asn Gly Ser Val Val Ala 
    610                 615                 620                 


Met Thr Gly Asp Gly Val Asn Asp Ala Val Ala Leu Lys Ala Ala Asp 
625                 630                 635                 640 


Ile Gly Val Ala Met Gly Gln Thr Gly Thr Asp Val Cys Lys Glu Ala 
                645                 650                 655     


Ala Asp Met Ile Leu Val Asp Asp Asp Phe Gln Thr Ile Met Ser Ala 
            660                 665                 670         


Ile Glu Glu Gly Lys Gly Ile Tyr Asn Asn Ile Lys Asn Phe Val Arg 
        675                 680                 685             


Phe Gln Leu Ser Thr Ser Ile Ala Ala Leu Thr Leu Ile Ser Leu Ala 
    690                 695                 700                 


Thr Leu Met Asn Phe Pro Asn Pro Leu Asn Ala Met Gln Ile Leu Trp 
705                 710                 715                 720 


Ile Asn Ile Ile Met Asp Gly Pro Pro Ala Gln Ser Leu Gly Val Glu 
                725                 730                 735     


Pro Val Asp Lys Asp Val Ile Arg Lys Pro Pro Arg Asn Trp Lys Asp 
            740                 745                 750         


Ser Ile Leu Thr Lys Asn Leu Ile Leu Lys Ile Leu Val Ser Ser Ile 
        755                 760                 765             


Ile Ile Val Cys Gly Thr Leu Phe Val Phe Trp Arg Glu Leu Arg Asp 
    770                 775                 780                 


Asn Val Ile Thr Pro Arg Asp Thr Thr Met Thr Phe Thr Cys Phe Val 
785                 790                 795                 800 


Phe Phe Asp Met Phe Asn Ala Leu Ser Ser Arg Ser Gln Thr Lys Ser 
                805                 810                 815     


Val Phe Glu Ile Gly Leu Cys Ser Asn Arg Met Phe Cys Tyr Ala Val 
            820                 825                 830         


Leu Gly Ser Ile Met Gly Gln Leu Leu Val Ile Tyr Phe Pro Pro Leu 
        835                 840                 845             


Gln Lys Val Phe Gln Thr Glu Ser Leu Ser Ile Leu Asp Leu Leu Phe 
    850                 855                 860                 


Leu Leu Gly Leu Thr Ser Ser Val Cys Ile Val Ala Glu Ile Ile Lys 
865                 870                 875                 880 


Lys Val Glu Arg Ser Arg Glu Lys Ile Gln Lys His Val Trp Leu Trp 
                885                 890                 895     


Glu Arg Ser Gly Gln Gln Leu Val Glu Ile His Pro His Leu Glu Thr 
            900                 905                 910         


Gly Leu Pro Leu Thr Glu Asp Val Ser Cys Val 
        915                 920             


<210>  51
<211>  131
<212>  PRT
<213>  Homo sapiens

<400>  51

Met Asp Leu Leu Gly Lys Gln Leu Ser Phe Tyr Ser Phe Gly Ile Ile 
1               5                   10                  15      


Gly Ile Ile Met Leu Val Gly Trp Leu Leu Gly Lys Asp Ile Leu Glu 
            20                  25                  30          


Met Phe Thr Ile Ser Val Ser Leu Ala Val Ala Ala Ile Pro Glu Gly 
        35                  40                  45              


Leu Pro Ile Val Val Thr Val Thr Leu Ala Leu Gly Val Met Arg Met 
    50                  55                  60                  


Val Lys Lys Arg Ala Ile Val Lys Lys Leu Pro Ile Val Glu Thr Leu 
65                  70                  75                  80  


Gly Cys Cys Asn Val Ile Cys Ser Asp Lys Thr Gly Thr Leu Thr Lys 
                85                  90                  95      


Asn Glu Met Thr Val Thr His Ile Phe Thr Ser Asp Gly Leu His Ala 
            100                 105                 110         


Glu Val Thr Gly Val Gly Tyr Asn Gln Phe Gly Glu Val Ile Val Asp 
        115                 120                 125             


Gly Asp Val 
    130     


<210>  52
<211>  888
<212>  PRT
<213>  Homo sapiens

<400>  52

Met Lys Val Ala Arg Phe Gln Lys Ile Pro Asn Gly Glu Asn Glu Thr 
1               5                   10                  15      


Met Ile Pro Val Leu Thr Ser Lys Lys Ala Ser Glu Leu Pro Val Ser 
            20                  25                  30          


Glu Val Ala Ser Ile Leu Gln Ala Asp Leu Gln Asn Gly Leu Asn Lys 
        35                  40                  45              


Cys Glu Val Ser His Arg Arg Ala Phe His Gly Trp Asn Glu Phe Asp 
    50                  55                  60                  


Ile Ser Glu Asp Glu Pro Leu Trp Lys Lys Tyr Ile Ser Gln Phe Lys 
65                  70                  75                  80  


Asn Pro Leu Ile Met Leu Leu Leu Ala Ser Ala Val Ile Ser Val Leu 
                85                  90                  95      


Met His Gln Phe Asp Asp Ala Val Ser Ile Thr Val Ala Ile Leu Ile 
            100                 105                 110         


Val Val Thr Val Ala Phe Val Gln Glu Tyr Arg Ser Glu Lys Ser Leu 
        115                 120                 125             


Glu Glu Leu Ser Lys Leu Val Pro Pro Glu Cys His Cys Val Arg Glu 
    130                 135                 140                 


Gly Lys Leu Glu His Thr Leu Ala Arg Asp Leu Val Pro Gly Asp Thr 
145                 150                 155                 160 


Val Cys Leu Ser Val Gly Asp Arg Val Pro Ala Asp Leu Arg Leu Phe 
                165                 170                 175     


Glu Ala Val Asp Leu Ser Ile Asp Glu Ser Ser Leu Thr Gly Glu Thr 
            180                 185                 190         


Thr Pro Cys Ser Lys Val Thr Ala Pro Gln Pro Ala Ala Thr Asn Gly 
        195                 200                 205             


Asp Leu Ala Ser Arg Ser Asn Ile Ala Phe Met Gly Thr Leu Val Arg 
    210                 215                 220                 


Cys Gly Lys Ala Lys Gly Val Val Ile Gly Thr Gly Glu Asn Ser Glu 
225                 230                 235                 240 


Phe Gly Glu Val Phe Lys Met Met Gln Ala Glu Glu Ala Pro Lys Thr 
                245                 250                 255     


Pro Leu Gln Lys Ser Met Asp Leu Leu Gly Lys Gln Leu Ser Phe Tyr 
            260                 265                 270         


Ser Phe Gly Ile Ile Gly Ile Ile Met Leu Val Gly Trp Leu Leu Gly 
        275                 280                 285             


Lys Asp Ile Leu Glu Met Phe Thr Ile Ser Val Ser Leu Ala Val Ala 
    290                 295                 300                 


Ala Ile Pro Glu Gly Leu Pro Ile Val Val Thr Val Thr Leu Ala Leu 
305                 310                 315                 320 


Gly Val Met Arg Met Val Lys Lys Arg Ala Ile Val Lys Lys Leu Pro 
                325                 330                 335     


Ile Val Glu Thr Leu Gly Cys Cys Asn Val Ile Cys Ser Asp Lys Thr 
            340                 345                 350         


Gly Thr Leu Thr Lys Asn Glu Met Thr Val Thr His Ile Phe Thr Ser 
        355                 360                 365             


Asp Gly Leu His Ala Glu Val Thr Gly Val Gly Tyr Asn Gln Phe Gly 
    370                 375                 380                 


Glu Val Ile Val Asp Gly Asp Val Val His Gly Phe Tyr Asn Pro Ala 
385                 390                 395                 400 


Val Ser Arg Ile Val Glu Ala Gly Cys Val Cys Asn Asp Ala Val Ile 
                405                 410                 415     


Arg Asn Asn Thr Leu Met Gly Lys Pro Thr Glu Gly Ala Leu Ile Ala 
            420                 425                 430         


Leu Ala Met Lys Met Gly Leu Asp Gly Leu Gln Gln Asp Tyr Ile Arg 
        435                 440                 445             


Lys Ala Glu Tyr Pro Phe Ser Ser Glu Gln Lys Trp Met Ala Val Lys 
    450                 455                 460                 


Cys Val His Arg Thr Gln Gln Asp Arg Pro Glu Ile Cys Phe Met Lys 
465                 470                 475                 480 


Gly Ala Tyr Glu Gln Val Ile Lys Tyr Cys Thr Thr Tyr Gln Ser Lys 
                485                 490                 495     


Gly Gln Thr Leu Thr Leu Thr Gln Gln Gln Arg Asp Val Tyr Gln Gln 
            500                 505                 510         


Glu Lys Ala Arg Met Gly Ser Ala Gly Leu Arg Val Leu Ala Leu Ala 
        515                 520                 525             


Ser Gly Pro Glu Leu Gly Gln Leu Thr Phe Leu Gly Leu Val Gly Ile 
    530                 535                 540                 


Ile Asp Pro Pro Arg Thr Gly Val Lys Glu Ala Val Thr Thr Leu Ile 
545                 550                 555                 560 


Ala Ser Gly Val Ser Ile Lys Met Ile Thr Gly Asp Ser Gln Glu Thr 
                565                 570                 575     


Ala Val Ala Ile Ala Ser Arg Leu Gly Leu Tyr Ser Lys Thr Ser Gln 
            580                 585                 590         


Ser Val Ser Gly Glu Glu Ile Asp Ala Met Asp Val Gln Gln Leu Ser 
        595                 600                 605             


Gln Ile Val Pro Lys Val Ala Val Phe Tyr Arg Ala Ser Pro Arg His 
    610                 615                 620                 


Lys Met Lys Ile Ile Lys Ser Leu Gln Lys Asn Gly Ser Val Val Ala 
625                 630                 635                 640 


Met Thr Gly Asp Gly Val Asn Asp Ala Val Ala Leu Lys Ala Ala Asp 
                645                 650                 655     


Ile Gly Val Ala Met Gly Gln Thr Gly Thr Asp Val Cys Lys Glu Ala 
            660                 665                 670         


Ala Asp Met Ile Leu Val Asp Asp Asp Phe Gln Thr Ile Met Ser Ala 
        675                 680                 685             


Ile Glu Glu Gly Lys Gly Ile Tyr Asn Asn Ile Lys Asn Phe Val Arg 
    690                 695                 700                 


Phe Gln Leu Ser Thr Ser Ile Ala Ala Leu Thr Leu Ile Ser Leu Ala 
705                 710                 715                 720 


Thr Leu Met Asn Phe Pro Asn Pro Leu Asn Ala Met Gln Ile Leu Trp 
                725                 730                 735     


Ile Asn Ile Ile Met Asp Gly Pro Pro Ala Gln Ser Leu Gly Val Glu 
            740                 745                 750         


Pro Val Asp Lys Asp Val Ile Arg Lys Pro Pro Arg Asn Trp Lys Asp 
        755                 760                 765             


Ser Ile Leu Thr Lys Asn Leu Ile Leu Lys Ile Leu Val Ser Ser Ile 
    770                 775                 780                 


Ile Ile Val Cys Gly Thr Leu Phe Val Phe Trp Arg Glu Leu Arg Asp 
785                 790                 795                 800 


Asn Val Ile Thr Pro Arg Asp Thr Thr Met Thr Phe Thr Cys Phe Val 
                805                 810                 815     


Phe Phe Asp Met Phe Asn Ala Leu Ser Ser Arg Ser Gln Thr Lys Ser 
            820                 825                 830         


Val Phe Glu Ile Gly Leu Cys Ser Asn Arg Met Phe Cys Tyr Ala Val 
        835                 840                 845             


Leu Gly Ser Ile Met Gly Gln Leu Leu Val Ile Tyr Phe Pro Pro Leu 
    850                 855                 860                 


Gln Lys Val Phe Gln Thr Glu Ser Leu Ser Ile Leu Gly Leu Ala Leu 
865                 870                 875                 880 


Gly Glu Glu Trp Thr Ala Ala Gly 
                885             


<210>  53
<211>  233
<212>  PRT
<213>  Homo sapiens

<400>  53

Met Leu Gly Ile Trp Thr Leu Leu Pro Leu Val Leu Thr Ser Val Ala 
1               5                   10                  15      


Arg Leu Ser Ser Lys Ser Val Asn Ala Gln Val Thr Asp Ile Asn Ser 
            20                  25                  30          


Lys Gly Leu Glu Leu Arg Lys Thr Val Thr Thr Val Glu Thr Gln Asn 
        35                  40                  45              


Leu Glu Gly Leu His His Asp Gly Gln Phe Cys His Lys Pro Cys Pro 
    50                  55                  60                  


Pro Gly Glu Arg Lys Ala Arg Asp Cys Thr Val Asn Gly Asp Glu Pro 
65                  70                  75                  80  


Asp Cys Val Pro Cys Gln Glu Gly Lys Glu Tyr Thr Asp Lys Ala His 
                85                  90                  95      


Phe Ser Ser Lys Cys Arg Arg Cys Arg Leu Cys Asp Glu Gly His Gly 
            100                 105                 110         


Leu Glu Val Glu Ile Asn Cys Thr Arg Thr Gln Asn Thr Lys Cys Arg 
        115                 120                 125             


Cys Lys Pro Asn Phe Phe Cys Asn Ser Thr Val Cys Glu His Cys Asp 
    130                 135                 140                 


Pro Cys Thr Lys Cys Glu His Gly Ile Ile Lys Glu Cys Thr Leu Thr 
145                 150                 155                 160 


Ser Asn Thr Lys Cys Lys Glu Glu Gly Ser Arg Ser Asn Leu Gly Trp 
                165                 170                 175     


Leu Cys Leu Leu Leu Leu Pro Ile Pro Leu Ile Val Trp Val Lys Arg 
            180                 185                 190         


Lys Glu Val Gln Lys Thr Cys Arg Lys His Arg Lys Glu Asn Gln Gly 
        195                 200                 205             


Ser His Glu Ser Pro Thr Leu Asn Pro Glu Thr Val Ala Ile Asn Leu 
    210                 215                 220                 


Ser Asp Tyr Phe Leu Phe Phe Arg Cys 
225                 230             


<210>  54
<211>  220
<212>  PRT
<213>  Homo sapiens

<400>  54

Met Leu Gly Ile Trp Thr Leu Leu Pro Leu Val Leu Thr Ser Val Ala 
1               5                   10                  15      


Arg Leu Ser Ser Lys Ser Val Asn Ala Gln Val Thr Asp Ile Asn Ser 
            20                  25                  30          


Lys Gly Leu Glu Leu Arg Lys Thr Val Thr Thr Val Glu Thr Gln Asn 
        35                  40                  45              


Leu Glu Gly Leu His His Asp Gly Gln Phe Cys His Lys Pro Cys Pro 
    50                  55                  60                  


Pro Gly Glu Arg Lys Ala Arg Asp Cys Thr Val Asn Gly Asp Glu Pro 
65                  70                  75                  80  


Asp Cys Val Pro Cys Gln Glu Gly Lys Glu Tyr Thr Asp Lys Ala His 
                85                  90                  95      


Phe Ser Ser Lys Cys Arg Arg Cys Arg Leu Cys Asp Glu Gly His Gly 
            100                 105                 110         


Leu Glu Val Glu Ile Asn Cys Thr Arg Thr Gln Asn Thr Lys Cys Arg 
        115                 120                 125             


Cys Lys Pro Asn Phe Phe Cys Asn Ser Thr Val Cys Glu His Cys Asp 
    130                 135                 140                 


Pro Cys Thr Lys Cys Glu His Gly Ile Ile Lys Glu Cys Thr Leu Thr 
145                 150                 155                 160 


Ser Asn Thr Lys Cys Lys Glu Glu Gly Ser Arg Ser Asn Leu Gly Trp 
                165                 170                 175     


Leu Cys Leu Leu Leu Leu Pro Ile Pro Leu Ile Val Trp Val Lys Arg 
            180                 185                 190         


Lys Glu Val Gln Lys Thr Cys Arg Lys His Arg Lys Glu Asn Gln Gly 
        195                 200                 205             


Ser His Glu Ser Pro Thr Leu Asn Pro Met Leu Thr 
    210                 215                 220 


<210>  55
<211>  335
<212>  PRT
<213>  Homo sapiens

<400>  55

Met Leu Gly Ile Trp Thr Leu Leu Pro Leu Val Leu Thr Ser Val Ala 
1               5                   10                  15      


Arg Leu Ser Ser Lys Ser Val Asn Ala Gln Val Thr Asp Ile Asn Ser 
            20                  25                  30          


Lys Gly Leu Glu Leu Arg Lys Thr Val Thr Thr Val Glu Thr Gln Asn 
        35                  40                  45              


Leu Glu Gly Leu His His Asp Gly Gln Phe Cys His Lys Pro Cys Pro 
    50                  55                  60                  


Pro Gly Glu Arg Lys Ala Arg Asp Cys Thr Val Asn Gly Asp Glu Pro 
65                  70                  75                  80  


Asp Cys Val Pro Cys Gln Glu Gly Lys Glu Tyr Thr Asp Lys Ala His 
                85                  90                  95      


Phe Ser Ser Lys Cys Arg Arg Cys Arg Leu Cys Asp Glu Gly His Gly 
            100                 105                 110         


Leu Glu Val Glu Ile Asn Cys Thr Arg Thr Gln Asn Thr Lys Cys Arg 
        115                 120                 125             


Cys Lys Pro Asn Phe Phe Cys Asn Ser Thr Val Cys Glu His Cys Asp 
    130                 135                 140                 


Pro Cys Thr Lys Cys Glu His Gly Ile Ile Lys Glu Cys Thr Leu Thr 
145                 150                 155                 160 


Ser Asn Thr Lys Cys Lys Glu Glu Gly Ser Arg Ser Asn Leu Gly Trp 
                165                 170                 175     


Leu Cys Leu Leu Leu Leu Pro Ile Pro Leu Ile Val Trp Val Lys Arg 
            180                 185                 190         


Lys Glu Val Gln Lys Thr Cys Arg Lys His Arg Lys Glu Asn Gln Gly 
        195                 200                 205             


Ser His Glu Ser Pro Thr Leu Asn Pro Glu Thr Val Ala Ile Asn Leu 
    210                 215                 220                 


Ser Asp Val Asp Leu Ser Lys Tyr Ile Thr Thr Ile Ala Gly Val Met 
225                 230                 235                 240 


Thr Leu Ser Gln Val Lys Gly Phe Val Arg Lys Asn Gly Val Asn Glu 
                245                 250                 255     


Ala Lys Ile Asp Glu Ile Lys Asn Asp Asn Val Gln Asp Thr Ala Glu 
            260                 265                 270         


Gln Lys Val Gln Leu Leu Arg Asn Trp His Gln Leu His Gly Lys Lys 
        275                 280                 285             


Glu Ala Tyr Asp Thr Leu Ile Lys Asp Leu Lys Lys Ala Asn Leu Cys 
    290                 295                 300                 


Thr Leu Ala Glu Lys Ile Gln Thr Ile Ile Leu Lys Asp Ile Thr Ser 
305                 310                 315                 320 


Asp Ser Glu Asn Ser Asn Phe Arg Asn Glu Ile Gln Ser Leu Val 
                325                 330                 335 


<210>  56
<211>  314
<212>  PRT
<213>  Homo sapiens

<400>  56

Met Leu Gly Ile Trp Thr Leu Leu Pro Leu Val Leu Thr Ser Val Ala 
1               5                   10                  15      


Arg Leu Ser Ser Lys Ser Val Asn Ala Gln Val Thr Asp Ile Asn Ser 
            20                  25                  30          


Lys Gly Leu Glu Leu Arg Lys Thr Val Thr Thr Val Glu Thr Gln Asn 
        35                  40                  45              


Leu Glu Gly Leu His His Asp Gly Gln Phe Cys His Lys Pro Cys Pro 
    50                  55                  60                  


Pro Gly Glu Arg Lys Ala Arg Asp Cys Thr Val Asn Gly Asp Glu Pro 
65                  70                  75                  80  


Asp Cys Val Pro Cys Gln Glu Gly Lys Glu Tyr Thr Asp Lys Ala His 
                85                  90                  95      


Phe Ser Ser Lys Cys Arg Arg Cys Arg Leu Cys Asp Glu Gly His Gly 
            100                 105                 110         


Leu Glu Val Glu Ile Asn Cys Thr Arg Thr Gln Asn Thr Lys Cys Arg 
        115                 120                 125             


Cys Lys Pro Asn Phe Phe Cys Asn Ser Thr Val Cys Glu His Cys Asp 
    130                 135                 140                 


Pro Cys Thr Lys Cys Glu His Gly Ile Ile Lys Glu Cys Thr Leu Thr 
145                 150                 155                 160 


Ser Asn Thr Lys Cys Lys Glu Glu Val Lys Arg Lys Glu Val Gln Lys 
                165                 170                 175     


Thr Cys Arg Lys His Arg Lys Glu Asn Gln Gly Ser His Glu Ser Pro 
            180                 185                 190         


Thr Leu Asn Pro Glu Thr Val Ala Ile Asn Leu Ser Asp Val Asp Leu 
        195                 200                 205             


Ser Lys Tyr Ile Thr Thr Ile Ala Gly Val Met Thr Leu Ser Gln Val 
    210                 215                 220                 


Lys Gly Phe Val Arg Lys Asn Gly Val Asn Glu Ala Lys Ile Asp Glu 
225                 230                 235                 240 


Ile Lys Asn Asp Asn Val Gln Asp Thr Ala Glu Gln Lys Val Gln Leu 
                245                 250                 255     


Leu Arg Asn Trp His Gln Leu His Gly Lys Lys Glu Ala Tyr Asp Thr 
            260                 265                 270         


Leu Ile Lys Asp Leu Lys Lys Ala Asn Leu Cys Thr Leu Ala Glu Lys 
        275                 280                 285             


Ile Gln Thr Ile Ile Leu Lys Asp Ile Thr Ser Asp Ser Glu Asn Ser 
    290                 295                 300                 


Asn Phe Arg Asn Glu Ile Gln Ser Leu Val 
305                 310                 


<210>  57
<211>  86
<212>  PRT
<213>  Homo sapiens

<400>  57

Met Leu Gly Ile Trp Thr Leu Leu Pro Leu Val Leu Thr Ser Val Ala 
1               5                   10                  15      


Arg Leu Ser Ser Lys Ser Val Asn Ala Gln Val Thr Asp Ile Asn Ser 
            20                  25                  30          


Lys Gly Leu Glu Leu Arg Lys Thr Val Thr Thr Val Glu Thr Gln Asn 
        35                  40                  45              


Leu Glu Gly Leu His His Asp Gly Gln Phe Cys His Lys Pro Cys Pro 
    50                  55                  60                  


Pro Asp Val Asn Met Glu Ser Ser Arg Asn Ala His Ser Pro Ala Thr 
65                  70                  75                  80  


Pro Ser Ala Lys Arg Lys 
                85      


<210>  58
<211>  103
<212>  PRT
<213>  Homo sapiens

<400>  58

Met Leu Gly Ile Trp Thr Leu Leu Pro Leu Val Leu Thr Ser Val Ala 
1               5                   10                  15      


Arg Leu Ser Ser Lys Ser Val Asn Ala Gln Val Thr Asp Ile Asn Ser 
            20                  25                  30          


Lys Gly Leu Glu Leu Arg Lys Thr Val Thr Thr Val Glu Thr Gln Asn 
        35                  40                  45              


Leu Glu Gly Leu His His Asp Gly Gln Phe Cys His Lys Pro Cys Pro 
    50                  55                  60                  


Pro Asp Val Asn Met Glu Ser Ser Arg Asn Ala His Ser Pro Ala Thr 
65                  70                  75                  80  


Pro Ser Ala Lys Arg Lys Asp Pro Asp Leu Thr Trp Gly Gly Phe Val 
                85                  90                  95      


Phe Phe Phe Cys Gln Phe His 
            100             


<210>  59
<211>  149
<212>  PRT
<213>  Homo sapiens

<400>  59

Met Leu Gly Ile Trp Thr Leu Leu Pro Leu Val Leu Thr Ser Val Ala 
1               5                   10                  15      


Arg Leu Ser Ser Lys Ser Val Asn Ala Gln Val Thr Asp Ile Asn Ser 
            20                  25                  30          


Lys Gly Leu Glu Leu Arg Lys Thr Val Thr Thr Val Glu Thr Gln Asn 
        35                  40                  45              


Leu Glu Gly Leu His His Asp Gly Gln Phe Cys His Lys Pro Cys Pro 
    50                  55                  60                  


Pro Gly Glu Arg Lys Ala Arg Asp Cys Thr Val Asn Gly Asp Glu Pro 
65                  70                  75                  80  


Asp Cys Val Pro Cys Gln Glu Gly Lys Glu Tyr Thr Asp Lys Ala His 
                85                  90                  95      


Phe Ser Ser Lys Cys Arg Arg Cys Arg Leu Cys Asp Glu Gly His Asp 
            100                 105                 110         


Val Asn Met Glu Ser Ser Arg Asn Ala His Ser Pro Ala Thr Pro Ser 
        115                 120                 125             


Ala Lys Arg Lys Asp Pro Asp Leu Thr Trp Gly Gly Phe Val Phe Phe 
    130                 135                 140                 


Phe Cys Gln Phe His 
145                 


<210>  60
<211>  132
<212>  PRT
<213>  Homo sapiens

<400>  60

Met Leu Gly Ile Trp Thr Leu Leu Pro Leu Val Leu Thr Ser Val Ala 
1               5                   10                  15      


Arg Leu Ser Ser Lys Ser Val Asn Ala Gln Val Thr Asp Ile Asn Ser 
            20                  25                  30          


Lys Gly Leu Glu Leu Arg Lys Thr Val Thr Thr Val Glu Thr Gln Asn 
        35                  40                  45              


Leu Glu Gly Leu His His Asp Gly Gln Phe Cys His Lys Pro Cys Pro 
    50                  55                  60                  


Pro Gly Glu Arg Lys Ala Arg Asp Cys Thr Val Asn Gly Asp Glu Pro 
65                  70                  75                  80  


Asp Cys Val Pro Cys Gln Glu Gly Lys Glu Tyr Thr Asp Lys Ala His 
                85                  90                  95      


Phe Ser Ser Lys Cys Arg Arg Cys Arg Leu Cys Asp Glu Gly His Asp 
            100                 105                 110         


Val Asn Met Glu Ser Ser Arg Asn Ala His Ser Pro Ala Thr Pro Ser 
        115                 120                 125             


Ala Lys Arg Lys 
    130         


<210>  61
<211>  149
<212>  PRT
<213>  Homo sapiens

<400>  61

Met Leu Gly Ile Trp Thr Leu Leu Pro Leu Val Leu Thr Ser Val Ala 
1               5                   10                  15      


Arg Leu Ser Ser Lys Ser Val Asn Ala Gln Val Thr Asp Ile Asn Ser 
            20                  25                  30          


Lys Gly Leu Glu Leu Arg Lys Thr Val Thr Thr Val Glu Thr Gln Asn 
        35                  40                  45              


Leu Glu Gly Leu His His Asp Gly Gln Phe Cys His Lys Pro Cys Pro 
    50                  55                  60                  


Pro Gly Glu Arg Lys Ala Arg Asp Cys Thr Val Asn Gly Asp Glu Pro 
65                  70                  75                  80  


Asp Cys Val Pro Cys Gln Glu Gly Lys Glu Tyr Thr Asp Lys Ala His 
                85                  90                  95      


Phe Ser Ser Lys Cys Arg Arg Cys Arg Leu Cys Asp Glu Gly His Asp 
            100                 105                 110         


Val Asn Met Glu Ser Ser Arg Asn Ala His Ser Pro Ala Thr Pro Ser 
        115                 120                 125             


Ala Lys Arg Lys Asp Pro Asp Leu Thr Trp Gly Gly Phe Val Phe Phe 
    130                 135                 140                 


Phe Cys Gln Phe His 
145                 


<210>  62
<211>  244
<212>  PRT
<213>  Homo sapiens

<400>  62

Met Leu Gly Ile Trp Thr Leu Leu Pro Leu Val Leu Thr Ser Val Ala 
1               5                   10                  15      


Arg Leu Ser Ser Lys Ser Val Asn Ala Gln Val Thr Asp Ile Asn Ser 
            20                  25                  30          


Lys Gly Leu Glu Leu Arg Lys Thr Val Thr Thr Val Glu Thr Gln Asn 
        35                  40                  45              


Leu Glu Gly Leu His His Asp Gly Gln Phe Cys His Lys Pro Cys Pro 
    50                  55                  60                  


Pro Gly Glu Arg Lys Ala Arg Asp Cys Thr Val Asn Gly Asp Glu Pro 
65                  70                  75                  80  


Asp Cys Val Pro Cys Gln Glu Gly Lys Glu Tyr Thr Asp Lys Ala His 
                85                  90                  95      


Phe Ser Ser Lys Cys Arg Arg Cys Arg Leu Cys Asp Glu Gly His Gly 
            100                 105                 110         


Leu Glu Val Glu Ile Asn Cys Thr Arg Thr Gln Asn Thr Lys Cys Arg 
        115                 120                 125             


Cys Lys Pro Asn Phe Phe Cys Asn Ser Thr Val Cys Glu His Cys Asp 
    130                 135                 140                 


Pro Cys Thr Lys Cys Glu His Gly Ile Ile Lys Glu Cys Thr Leu Thr 
145                 150                 155                 160 


Ser Asn Thr Lys Cys Lys Glu Glu Gly Ser Arg Ser Asn Leu Gly Trp 
                165                 170                 175     


Leu Cys Leu Leu Leu Leu Pro Ile Pro Leu Ile Val Trp Val Lys Arg 
            180                 185                 190         


Lys Glu Val Gln Lys Thr Cys Arg Lys His Arg Lys Glu Asn Gln Gly 
        195                 200                 205             


Ser His Glu Ser Pro Thr Leu Asn Pro Met Glu Ser Cys Ser Ile Ala 
    210                 215                 220                 


Gln Ala Gly Val Gln Gly Cys Asn His Gly Ser Leu Gln Pro Gln Ser 
225                 230                 235                 240 


Pro Gly Leu Lys 
                


<210>  63
<211>  373
<212>  PRT
<213>  Homo sapiens

<400>  63

Met Leu Arg Ser Val Trp Asn Phe Leu Lys Arg His Lys Lys Lys Cys 
1               5                   10                  15      


Ile Phe Leu Gly Thr Val Leu Gly Gly Val Tyr Ile Leu Gly Lys Tyr 
            20                  25                  30          


Gly Gln Lys Lys Ile Arg Glu Ile Gln Glu Arg Glu Ala Ala Glu Tyr 
        35                  40                  45              


Ile Ala Gln Ala Arg Arg Gln Tyr His Phe Glu Ser Asn Gln Arg Thr 
    50                  55                  60                  


Cys Asn Met Thr Val Leu Ser Met Leu Pro Thr Leu Arg Glu Ala Leu 
65                  70                  75                  80  


Met Gln Gln Leu Asn Ser Glu Ser Leu Thr Ala Leu Leu Lys Asn Arg 
                85                  90                  95      


Pro Ser Asn Lys Leu Glu Ile Trp Glu Asp Leu Lys Ile Ile Ser Phe 
            100                 105                 110         


Thr Arg Ser Thr Val Ala Val Tyr Ser Thr Cys Met Leu Val Val Leu 
        115                 120                 125             


Leu Arg Val Gln Leu Asn Ile Ile Gly Gly Tyr Ile Tyr Leu Asp Asn 
    130                 135                 140                 


Ala Ala Val Gly Lys Asn Gly Thr Thr Ile Leu Ala Pro Pro Asp Val 
145                 150                 155                 160 


Gln Gln Gln Tyr Leu Ser Ser Ile Gln His Leu Leu Gly Asp Gly Leu 
                165                 170                 175     


Thr Glu Leu Ile Thr Val Ile Lys Gln Ala Val Gln Lys Val Leu Gly 
            180                 185                 190         


Ser Val Ser Leu Lys His Ser Leu Ser Leu Leu Asp Leu Glu Gln Lys 
        195                 200                 205             


Leu Lys Glu Ile Arg Asn Leu Val Glu Gln His Lys Ser Ser Ser Trp 
    210                 215                 220                 


Ile Asn Lys Asp Gly Ser Lys Pro Leu Leu Cys His Tyr Met Met Pro 
225                 230                 235                 240 


Asp Glu Glu Thr Pro Leu Ala Val Gln Ala Cys Gly Leu Ser Pro Arg 
                245                 250                 255     


Asp Ile Thr Thr Ile Lys Leu Leu Asn Glu Thr Arg Asp Met Leu Glu 
            260                 265                 270         


Ser Pro Asp Phe Ser Thr Val Leu Asn Thr Cys Leu Asn Arg Gly Phe 
        275                 280                 285             


Ser Arg Leu Leu Asp Asn Met Ala Glu Phe Phe Arg Pro Thr Glu Gln 
    290                 295                 300                 


Asp Leu Gln His Gly Asn Ser Met Asn Ser Leu Ser Ser Val Ser Leu 
305                 310                 315                 320 


Pro Leu Ala Lys Ile Ile Pro Ile Val Asn Gly Gln Ile His Ser Val 
                325                 330                 335     


Cys Ser Glu Thr Pro Ser His Phe Val Gln Asp Leu Leu Thr Met Glu 
            340                 345                 350         


Gln Val Lys Asp Phe Ala Ala Asn Val Tyr Glu Ala Phe Ser Thr Pro 
        355                 360                 365             


Gln Gln Leu Glu Lys 
    370             


<210>  64
<211>  182
<212>  PRT
<213>  Homo sapiens

<400>  64

Met Leu Arg Ser Val Trp Asn Phe Leu Lys Arg His Lys Lys Lys Cys 
1               5                   10                  15      


Ile Phe Leu Gly Thr Val Leu Gly Val Leu Ser Met Leu Pro Thr Leu 
            20                  25                  30          


Arg Glu Ala Leu Met Gln Gln Leu Asn Ser Glu Ser Leu Thr Ala Leu 
        35                  40                  45              


Leu Lys Asn Arg Pro Ser Asn Lys Leu Glu Ile Trp Glu Asp Leu Lys 
    50                  55                  60                  


Ile Ile Ser Phe Thr Arg Ser Thr Val Ala Val Tyr Ser Thr Cys Met 
65                  70                  75                  80  


Leu Val Val Leu Leu Arg Val Gln Leu Asn Ile Ile Gly Gly Tyr Ile 
                85                  90                  95      


Tyr Leu Asp Asn Ala Ala Val Gly Lys Asn Gly Thr Thr Ile Leu Ala 
            100                 105                 110         


Pro Pro Asp Val Gln Gln Gln Tyr Leu Ser Ser Ile Gln His Leu Leu 
        115                 120                 125             


Gly Asp Gly Leu Thr Glu Leu Ile Thr Val Ile Lys Gln Ala Val Gln 
    130                 135                 140                 


Lys Val Leu Gly Ser Val Ser Leu Lys His Ser Leu Ser Leu Leu Asp 
145                 150                 155                 160 


Leu Glu Gln Lys Leu Lys Glu Ile Arg Asn Leu Val Glu Gln His Lys 
                165                 170                 175     


Ser Ser Ser Trp Ile Asn 
            180         


<210>  65
<211>  188
<212>  PRT
<213>  Homo sapiens

<400>  65

Met Pro Gly Lys His Gln His Phe Gln Glu Pro Glu Val Gly Cys Cys 
1               5                   10                  15      


Gly Lys Tyr Phe Leu Phe Gly Phe Asn Ile Val Phe Trp Phe Ser Val 
            20                  25                  30          


Phe Leu Gly Leu Ile Phe Phe Leu Glu Leu Ala Thr Gly Ile Leu Ala 
        35                  40                  45              


Phe Val Phe Lys Asp Trp Ile Arg Asp Gln Leu Asn Leu Phe Ile Asn 
    50                  55                  60                  


Asn Asn Val Lys Ala Tyr Arg Asp Asp Ile Asp Leu Gln Asn Leu Ile 
65                  70                  75                  80  


Asp Phe Ala Gln Glu Tyr Glu Asp Val Leu Asn Thr Gln Cys Gly Tyr 
                85                  90                  95      


Asp Val Arg Leu Lys Leu Glu Leu Glu Gln Gln Gly Phe Ile His Thr 
            100                 105                 110         


Lys Gly Cys Val Gly Gln Phe Glu Lys Trp Leu Gln Asp Asn Leu Ile 
        115                 120                 125             


Val Val Ala Gly Val Phe Met Gly Ile Ala Leu Leu Gln Val Pro Leu 
    130                 135                 140                 


Trp Pro His Val Pro Leu Pro Leu Pro Gly Pro Pro Ser Leu Ser Pro 
145                 150                 155                 160 


His Leu Ser Ser Val Leu Gln Ile Phe Gly Ile Cys Leu Ala Gln Asn 
                165                 170                 175     


Leu Val Ser Asp Ile Lys Ala Val Lys Ala Asn Trp 
            180                 185             


<210>  66
<211>  332
<212>  PRT
<213>  Homo sapiens

<400>  66

Met Pro Gly Lys His Gln His Phe Gln Glu Pro Glu Val Gly Cys Cys 
1               5                   10                  15      


Gly Lys Tyr Phe Leu Phe Gly Phe Asn Ile Val Phe Trp Val Leu Gly 
            20                  25                  30          


Ala Leu Phe Leu Ala Ile Gly Leu Trp Ala Trp Gly Glu Lys Gly Val 
        35                  40                  45              


Leu Ser Asn Ile Ser Ala Leu Thr Asp Leu Gly Gly Leu Asp Pro Val 
    50                  55                  60                  


Trp Leu Phe Val Val Val Gly Gly Val Met Ser Val Leu Gly Phe Ala 
65                  70                  75                  80  


Gly Cys Ile Gly Ala Leu Arg Glu Asn Thr Phe Leu Leu Lys Phe Phe 
                85                  90                  95      


Ser Val Phe Leu Gly Leu Ile Phe Phe Leu Glu Leu Ala Thr Gly Ile 
            100                 105                 110         


Leu Ala Phe Val Phe Lys Asp Trp Ile Arg Asp Gln Leu Asn Leu Phe 
        115                 120                 125             


Ile Asn Asn Asn Val Lys Ala Tyr Arg Asp Asp Ile Asp Leu Gln Asn 
    130                 135                 140                 


Leu Ile Asp Phe Ala Gln Glu Tyr Trp Ser Cys Cys Gly Ala Arg Gly 
145                 150                 155                 160 


Pro Asn Asp Trp Asn Leu Asn Ile Tyr Phe Asn Cys Thr Asp Leu Asn 
                165                 170                 175     


Pro Ser Arg Glu Arg Cys Gly Val Pro Phe Ser Cys Cys Val Arg Asp 
            180                 185                 190         


Pro Ala Glu Asp Val Leu Asn Thr Gln Cys Gly Tyr Asp Val Arg Leu 
        195                 200                 205             


Lys Leu Val Arg Gly Glu Leu Glu Gln Gln Gly Phe Ile His Thr Lys 
    210                 215                 220                 


Gly Cys Val Gly Gln Phe Glu Lys Trp Leu Gln Asp Asn Leu Ile Val 
225                 230                 235                 240 


Val Ala Gly Val Phe Met Gly Ile Ala Leu Leu Gln Ile Phe Gly Ile 
                245                 250                 255     


Cys Leu Ala Gln Asn Leu Val Ser Asp Ile Lys Ala Val Lys Ala Asn 
            260                 265                 270         


Trp Ser Lys Trp Asn Asp Asp Phe Glu Asn His Trp Leu Thr Pro Thr 
        275                 280                 285             


Ile Ser Glu Val Leu Ser Thr Ala Gly Pro Gln Gln Asn Ser Leu Thr 
    290                 295                 300                 


Gly Ala Pro Gly Pro Ala Pro Pro Ser Arg His Val Phe Phe Gly Leu 
305                 310                 315                 320 


Gly Gly Leu Tyr Pro Glu Pro Thr Phe Lys Asn Trp 
                325                 330         


<210>  67
<211>  58
<212>  PRT
<213>  Homo sapiens

<400>  67

Met Pro Gly Lys His Gln His Phe Gln Glu Pro Glu Val Gly Cys Cys 
1               5                   10                  15      


Gly Lys Tyr Phe Leu Phe Gly Phe Asn Ile Val Phe Trp Val Ser Ala 
            20                  25                  30          


Gly Cys Trp Glu Pro Cys Ser Trp Leu Ser Ala Ser Gly Pro Gly Val 
        35                  40                  45              


Arg Arg Ala Phe Ser Arg Thr Ser Gln Arg 
    50                  55              


<210>  68
<211>  309
<212>  PRT
<213>  Homo sapiens

<400>  68

Met Pro Gly Lys His Gln His Phe Gln Glu Pro Glu Val Gly Cys Cys 
1               5                   10                  15      


Gly Lys Tyr Phe Leu Phe Gly Phe Asn Ile Val Phe Trp Val Leu Gly 
            20                  25                  30          


Ala Leu Phe Leu Ala Ile Gly Leu Trp Ala Trp Gly Glu Lys Gly Val 
        35                  40                  45              


Leu Ser Asn Ile Ser Ala Leu Thr Asp Leu Gly Gly Leu Asp Pro Val 
    50                  55                  60                  


Trp Leu Phe Val Val Val Gly Gly Val Met Ser Val Leu Gly Phe Ala 
65                  70                  75                  80  


Gly Cys Ile Gly Ala Leu Arg Glu Asn Thr Phe Leu Leu Lys Phe Asp 
                85                  90                  95      


Trp Ile Arg Asp Gln Leu Asn Leu Phe Ile Asn Asn Asn Val Lys Ala 
            100                 105                 110         


Tyr Arg Asp Asp Ile Asp Leu Gln Asn Leu Ile Asp Phe Ala Gln Glu 
        115                 120                 125             


Tyr Trp Ser Cys Cys Gly Ala Arg Gly Pro Asn Asp Trp Asn Leu Asn 
    130                 135                 140                 


Ile Tyr Phe Asn Cys Thr Asp Leu Asn Pro Ser Arg Glu Arg Cys Gly 
145                 150                 155                 160 


Val Pro Phe Ser Cys Cys Val Arg Asp Pro Ala Glu Asp Val Leu Asn 
                165                 170                 175     


Thr Gln Cys Gly Tyr Asp Val Arg Leu Lys Leu Val Arg Gly Glu Leu 
            180                 185                 190         


Glu Gln Gln Gly Phe Ile His Thr Lys Gly Cys Val Gly Gln Phe Glu 
        195                 200                 205             


Lys Trp Leu Gln Asp Asn Leu Ile Val Val Ala Gly Val Phe Met Gly 
    210                 215                 220                 


Ile Ala Leu Leu Gln Ile Phe Gly Ile Cys Leu Ala Gln Asn Leu Val 
225                 230                 235                 240 


Ser Asp Ile Lys Ala Val Lys Ala Asn Trp Ser Lys Trp Asn Asp Asp 
                245                 250                 255     


Phe Glu Asn His Trp Leu Thr Pro Thr Ile Ser Glu Val Leu Ser Thr 
            260                 265                 270         


Ala Gly Pro Gln Gln Asn Ser Leu Thr Gly Ala Pro Gly Pro Ala Pro 
        275                 280                 285             


Pro Ser Arg His Val Phe Phe Gly Leu Gly Gly Leu Tyr Pro Glu Pro 
    290                 295                 300                 


Thr Phe Lys Asn Trp 
305                 


<210>  69
<211>  257
<212>  PRT
<213>  Homo sapiens

<400>  69

Met Pro Gly Lys His Gln His Phe Gln Glu Pro Glu Val Gly Cys Cys 
1               5                   10                  15      


Gly Lys Tyr Phe Leu Phe Gly Phe Asn Ile Val Phe Trp Val Leu Gly 
            20                  25                  30          


Ala Leu Phe Leu Ala Ile Gly Leu Trp Ala Trp Gly Glu Lys Gly Val 
        35                  40                  45              


Leu Ser Asn Ile Ser Ala Leu Thr Asp Leu Gly Gly Leu Asp Pro Val 
    50                  55                  60                  


Trp Leu Phe Val Val Val Gly Gly Val Met Ser Val Leu Gly Phe Ala 
65                  70                  75                  80  


Gly Cys Ile Gly Ala Leu Arg Glu Asn Thr Phe Leu Leu Lys Phe Leu 
                85                  90                  95      


Ala Thr Gly Ile Leu Ala Phe Val Phe Lys Asp Trp Ile Arg Asp Gln 
            100                 105                 110         


Leu Asn Leu Phe Ile Asn Asn Asn Val Lys Ala Tyr Arg Asp Asp Ile 
        115                 120                 125             


Asp Leu Gln Asn Leu Ile Asp Phe Ala Gln Glu Tyr Trp Ser Cys Cys 
    130                 135                 140                 


Gly Ala Arg Gly Pro Asn Asp Trp Asn Leu Asn Ile Tyr Phe Asn Cys 
145                 150                 155                 160 


Thr Asp Leu Asn Pro Ser Arg Glu Arg Cys Gly Val Pro Phe Ser Cys 
                165                 170                 175     


Cys Val Arg Asp Pro Ala Glu Asp Val Leu Asn Thr Gln Cys Gly Tyr 
            180                 185                 190         


Asp Val Arg Leu Lys Leu Glu Leu Glu Gln Gln Gly Phe Ile His Thr 
        195                 200                 205             


Lys Gly Cys Val Gly Gln Phe Glu Lys Trp Leu Gln Asp Asn Leu Ile 
    210                 215                 220                 


Val Val Ala Gly Val Phe Met Gly Ile Ala Leu Leu Gln Ile Phe Gly 
225                 230                 235                 240 


Ile Cys Leu Ala Gln Asn Leu Val Ser Asp Ile Lys Ala Val Lys Ala 
                245                 250                 255     


Asn 
    


<210>  70
<211>  203
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  70

Xaa Gly Lys His Gln His Phe Gln Glu Pro Glu Val Gly Cys Cys Gly 
1               5                   10                  15      


Lys Tyr Phe Leu Phe Gly Phe Asn Ile Val Phe Trp Phe Ser Val Phe 
            20                  25                  30          


Leu Gly Leu Ile Phe Phe Leu Glu Leu Ala Thr Gly Ile Leu Ala Phe 
        35                  40                  45              


Val Phe Lys Asp Trp Ile Arg Asp Gln Leu Asn Leu Phe Ile Asn Asn 
    50                  55                  60                  


Asn Val Lys Ala Tyr Arg Asp Asp Ile Asp Leu Gln Asn Leu Ile Asp 
65                  70                  75                  80  


Phe Ala Gln Glu Tyr Trp Ser Cys Cys Gly Ala Arg Gly Pro Asn Asp 
                85                  90                  95      


Trp Asn Leu Asn Ile Tyr Phe Asn Cys Thr Asp Leu Asn Pro Ser Arg 
            100                 105                 110         


Glu Arg Cys Gly Val Pro Phe Ser Cys Cys Val Arg Asp Pro Ala Glu 
        115                 120                 125             


Asp Val Leu Asn Thr Gln Cys Gly Tyr Asp Val Arg Leu Lys Leu Glu 
    130                 135                 140                 


Leu Glu Gln Gln Gly Phe Ile His Thr Lys Gly Cys Val Gly Gln Phe 
145                 150                 155                 160 


Glu Lys Trp Leu Gln Asp Asn Leu Ile Val Val Ala Gly Val Phe Met 
                165                 170                 175     


Gly Ile Ala Leu Leu Gln Ile Phe Gly Ile Cys Leu Ala Gln Asn Leu 
            180                 185                 190         


Val Ser Asp Ile Lys Ala Val Lys Ala Asn Trp 
        195                 200             


<210>  71
<211>  329
<212>  PRT
<213>  Homo sapiens

<400>  71

Met Pro Gly Lys His Gln His Phe Gln Glu Pro Glu Val Gly Cys Cys 
1               5                   10                  15      


Gly Lys Tyr Phe Leu Phe Gly Phe Asn Ile Val Phe Trp Val Leu Gly 
            20                  25                  30          


Ala Leu Phe Leu Ala Ile Gly Leu Trp Ala Trp Gly Glu Lys Gly Val 
        35                  40                  45              


Leu Ser Asn Ile Ser Ala Leu Thr Asp Leu Gly Gly Leu Asp Pro Val 
    50                  55                  60                  


Trp Leu Phe Val Val Val Gly Gly Val Met Ser Val Leu Gly Phe Ala 
65                  70                  75                  80  


Gly Cys Ile Gly Ala Leu Arg Glu Asn Thr Phe Leu Leu Lys Phe Phe 
                85                  90                  95      


Ser Val Phe Leu Gly Leu Ile Phe Phe Leu Glu Leu Ala Thr Gly Ile 
            100                 105                 110         


Leu Ala Phe Val Phe Lys Asp Trp Ile Arg Asp Gln Leu Asn Leu Phe 
        115                 120                 125             


Ile Asn Asn Asn Val Lys Ala Tyr Arg Asp Asp Ile Asp Leu Gln Asn 
    130                 135                 140                 


Leu Ile Asp Phe Ala Gln Glu Tyr Trp Ser Cys Cys Gly Ala Arg Gly 
145                 150                 155                 160 


Pro Asn Asp Trp Asn Leu Asn Ile Tyr Phe Asn Cys Thr Asp Leu Asn 
                165                 170                 175     


Pro Ser Arg Glu Arg Cys Gly Val Pro Phe Ser Cys Cys Val Arg Asp 
            180                 185                 190         


Pro Ala Glu Asp Val Leu Asn Thr Gln Cys Gly Tyr Asp Val Arg Leu 
        195                 200                 205             


Lys Leu Glu Leu Glu Gln Gln Gly Phe Ile His Thr Lys Gly Cys Val 
    210                 215                 220                 


Gly Gln Phe Glu Lys Trp Leu Gln Asp Asn Leu Ile Val Val Ala Gly 
225                 230                 235                 240 


Val Phe Met Gly Ile Ala Leu Leu Gln Ile Phe Gly Ile Cys Leu Ala 
                245                 250                 255     


Gln Asn Leu Val Ser Asp Ile Lys Ala Val Lys Ala Asn Trp Ser Lys 
            260                 265                 270         


Trp Asn Asp Asp Phe Glu Asn His Trp Leu Thr Pro Thr Ile Ser Glu 
        275                 280                 285             


Val Leu Ser Thr Ala Gly Pro Gln Gln Asn Ser Leu Thr Gly Ala Pro 
    290                 295                 300                 


Gly Pro Ala Pro Pro Ser Arg His Val Phe Phe Gly Leu Gly Gly Leu 
305                 310                 315                 320 


Tyr Pro Glu Pro Thr Phe Lys Asn Trp 
                325                 


<210>  72
<211>  263
<212>  PRT
<213>  Homo sapiens

<400>  72

Met Pro Gly Lys His Gln His Phe Gln Glu Pro Glu Val Gly Cys Cys 
1               5                   10                  15      


Gly Lys Tyr Phe Leu Phe Gly Phe Asn Ile Val Phe Trp Val Leu Gly 
            20                  25                  30          


Ala Leu Phe Leu Ala Ile Gly Leu Trp Ala Trp Gly Glu Lys Gly Val 
        35                  40                  45              


Leu Ser Asn Ile Ser Ala Leu Thr Asp Leu Gly Gly Leu Asp Pro Val 
    50                  55                  60                  


Trp Leu Phe Val Val Val Gly Gly Val Met Ser Val Leu Gly Phe Ala 
65                  70                  75                  80  


Gly Cys Ile Gly Ala Leu Arg Glu Asn Thr Phe Leu Leu Lys Phe Phe 
                85                  90                  95      


Ser Val Phe Leu Gly Leu Ile Phe Phe Leu Glu Leu Ala Thr Gly Ile 
            100                 105                 110         


Leu Ala Phe Val Phe Lys Asp Trp Ile Arg Asp Gln Leu Asn Leu Phe 
        115                 120                 125             


Ile Asn Asn Asn Val Lys Ala Tyr Arg Asp Asp Ile Asp Leu Gln Asn 
    130                 135                 140                 


Leu Ile Asp Phe Ala Gln Glu Tyr Trp Ser Cys Cys Gly Ala Arg Gly 
145                 150                 155                 160 


Pro Asn Asp Trp Asn Leu Asn Ile Tyr Phe Asn Cys Thr Asp Leu Asn 
                165                 170                 175     


Pro Ser Arg Glu Arg Cys Gly Val Pro Phe Ser Cys Cys Val Arg Asp 
            180                 185                 190         


Pro Ala Glu Asp Val Leu Asn Thr Gln Cys Gly Tyr Asp Val Arg Leu 
        195                 200                 205             


Lys Leu Glu Leu Glu Gln Gln Gly Phe Ile His Thr Lys Gly Cys Val 
    210                 215                 220                 


Gly Gln Phe Glu Lys Trp Leu Gln Asp Asn Leu Ile Val Val Ala Gly 
225                 230                 235                 240 


Val Phe Met Gly Ile Ala Leu Leu Gln Ile Phe Gly Ile Cys Leu Ala 
                245                 250                 255     


Gln Asn Leu Glu Gln Met Glu 
            260             


<210>  73
<211>  83
<212>  PRT
<213>  Homo sapiens

<400>  73

Met Ala Ala Ala Thr Ala Ser Pro Arg Ser Leu Leu Val Leu Leu Gln 
1               5                   10                  15      


Val Val Val Leu Ala Leu Ala Gln Ile Arg Gly Pro Pro Gly Glu Arg 
            20                  25                  30          


Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly Val Pro Gly Ser Asp Gly 
        35                  40                  45              


Ile Asp Gly Pro Pro Gly Pro Val Gly Leu Pro Gly Glu Ile Gly Ile 
    50                  55                  60                  


Arg Gly Pro Lys Gly Asp Pro Gly Pro Asp Gly Pro Ser Gly Pro Pro 
65                  70                  75                  80  


Gly Pro Pro 
            


<210>  74
<211>  689
<212>  PRT
<213>  Homo sapiens

<400>  74

Met Ala Ala Ala Thr Ala Ser Pro Arg Ser Leu Leu Val Leu Leu Gln 
1               5                   10                  15      


Val Val Val Leu Ala Leu Ala Gln Ile Arg Gly Pro Pro Gly Glu Arg 
            20                  25                  30          


Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly Val Pro Gly Ser Asp Gly 
        35                  40                  45              


Ile Asp Gly Asp Asn Gly Pro Pro Gly Lys Ala Gly Pro Pro Gly Pro 
    50                  55                  60                  


Lys Gly Glu Pro Gly Lys Ala Gly Pro Asp Gly Pro Asp Gly Lys Pro 
65                  70                  75                  80  


Gly Ile Asp Gly Leu Thr Gly Ala Lys Gly Glu Pro Gly Pro Met Gly 
                85                  90                  95      


Ile Pro Gly Val Lys Gly Gln Pro Gly Leu Pro Gly Pro Pro Gly Leu 
            100                 105                 110         


Pro Gly Pro Gly Phe Ala Gly Pro Pro Gly Pro Pro Gly Pro Val Gly 
        115                 120                 125             


Leu Pro Gly Glu Ile Gly Ile Arg Gly Pro Lys Gly Asp Pro Gly Pro 
    130                 135                 140                 


Asp Gly Pro Ser Gly Pro Pro Gly Pro Pro Gly Lys Pro Gly Arg Pro 
145                 150                 155                 160 


Gly Thr Ile Gln Gly Leu Glu Gly Ser Ala Asp Phe Leu Cys Pro Thr 
                165                 170                 175     


Asn Cys Pro Pro Gly Met Lys Gly Pro Pro Gly Leu Gln Gly Val Lys 
            180                 185                 190         


Gly His Ala Gly Lys Arg Gly Ile Leu Gly Asp Pro Gly His Gln Gly 
        195                 200                 205             


Lys Pro Gly Pro Lys Gly Asp Val Gly Ala Ser Gly Glu Gln Gly Ile 
    210                 215                 220                 


Pro Gly Pro Pro Gly Pro Gln Gly Ile Arg Gly Tyr Pro Gly Met Ala 
225                 230                 235                 240 


Gly Pro Lys Gly Glu Thr Gly Pro His Gly Tyr Lys Gly Met Val Gly 
                245                 250                 255     


Ala Ile Gly Ala Thr Gly Pro Pro Gly Glu Glu Gly Pro Arg Gly Pro 
            260                 265                 270         


Pro Gly Arg Ala Gly Glu Lys Gly Asp Glu Gly Ser Pro Gly Ile Arg 
        275                 280                 285             


Gly Pro Gln Gly Ile Thr Gly Pro Lys Gly Ala Thr Gly Pro Pro Gly 
    290                 295                 300                 


Ile Asn Gly Lys Asp Gly Thr Pro Gly Thr Pro Gly Met Lys Gly Ser 
305                 310                 315                 320 


Ala Gly Gln Ala Gly Gln Pro Gly Ser Pro Gly His Gln Gly Leu Ala 
                325                 330                 335     


Gly Val Pro Gly Gln Pro Gly Thr Lys Gly Gly Pro Gly Asp Gln Gly 
            340                 345                 350         


Glu Pro Gly Pro Gln Gly Leu Pro Gly Phe Ser Gly Pro Pro Gly Lys 
        355                 360                 365             


Glu Gly Glu Pro Gly Pro Arg Gly Glu Ile Gly Pro Gln Gly Ile Met 
    370                 375                 380                 


Gly Gln Lys Gly Asp Gln Gly Glu Arg Gly Pro Val Gly Gln Pro Gly 
385                 390                 395                 400 


Pro Gln Gly Arg Gln Gly Pro Lys Gly Glu Gln Gly Pro Pro Gly Ile 
                405                 410                 415     


Pro Gly Pro Gln Gly Leu Pro Gly Val Lys Gly Asp Lys Gly Ser Pro 
            420                 425                 430         


Gly Lys Thr Gly Pro Arg Gly Lys Val Gly Asp Pro Gly Val Ala Gly 
        435                 440                 445             


Leu Pro Gly Glu Lys Gly Glu Lys Gly Glu Ser Gly Glu Pro Gly Pro 
    450                 455                 460                 


Lys Gly Gln Gln Gly Val Arg Gly Glu Pro Gly Tyr Pro Gly Pro Ser 
465                 470                 475                 480 


Gly Asp Ala Gly Ala Pro Gly Val Gln Gly Tyr Pro Gly Pro Pro Gly 
                485                 490                 495     


Pro Arg Gly Leu Ala Gly Asn Arg Gly Val Pro Gly Gln Pro Gly Arg 
            500                 505                 510         


Gln Gly Val Glu Gly Arg Asp Ala Thr Asp Gln His Ile Val Asp Val 
        515                 520                 525             


Ala Leu Lys Met Leu Gln Glu Gln Leu Ala Glu Val Ala Val Ser Ala 
    530                 535                 540                 


Lys Arg Glu Ala Leu Gly Ala Val Gly Met Met Gly Pro Pro Gly Pro 
545                 550                 555                 560 


Pro Gly Pro Pro Gly Tyr Pro Gly Lys Gln Gly Pro His Gly His Pro 
                565                 570                 575     


Gly Pro Arg Gly Val Pro Gly Ile Val Gly Ala Val Gly Gln Ile Gly 
            580                 585                 590         


Asn Thr Gly Pro Lys Gly Lys Arg Gly Glu Lys Gly Asp Pro Gly Glu 
        595                 600                 605             


Val Gly Arg Gly His Pro Gly Met Pro Gly Pro Pro Gly Ile Pro Gly 
    610                 615                 620                 


Leu Pro Gly Arg Pro Gly Gln Ala Ile Asn Gly Lys Asp Gly Asp Arg 
625                 630                 635                 640 


Gly Ser Pro Gly Ala Pro Gly Glu Ala Gly Arg Pro Gly Leu Pro Gly 
                645                 650                 655     


Pro Val Gly Leu Pro Gly Phe Cys Glu Pro Ala Ala Cys Leu Gly Ala 
            660                 665                 670         


Ser Ala Tyr Ala Ser Ala Arg Leu Thr Glu Pro Gly Ser Ile Lys Gly 
        675                 680                 685             


Pro 
    


<210>  75
<211>  226
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  75

Xaa Ser Pro Phe Arg Gly Pro Pro Gly Ala Ala Gly Ala Arg Arg Gly 
1               5                   10                  15      


Pro Pro Gly Glu Arg Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly Val 
            20                  25                  30          


Pro Gly Ser Asp Gly Ile Asp Gly Asp Asn Gly Pro Pro Gly Lys Ala 
        35                  40                  45              


Gly Pro Pro Gly Pro Lys Gly Glu Pro Gly Lys Ala Gly Pro Asp Gly 
    50                  55                  60                  


Pro Asp Gly Lys Pro Gly Ile Asp Gly Leu Thr Gly Ala Lys Gly Glu 
65                  70                  75                  80  


Pro Gly Pro Met Gly Ile Pro Gly Val Lys Gly Gln Pro Gly Leu Pro 
                85                  90                  95      


Gly Pro Pro Gly Leu Pro Gly Pro Gly Phe Ala Gly Pro Pro Gly Pro 
            100                 105                 110         


Pro Gly Pro Val Gly Leu Pro Gly Glu Ile Gly Ile Arg Gly Pro Lys 
        115                 120                 125             


Gly Asp Pro Gly Pro Asp Gly Pro Ser Gly Pro Pro Gly Pro Pro Gly 
    130                 135                 140                 


Lys Pro Gly Arg Pro Gly Thr Ile Gln Gly Leu Glu Gly Ser Ala Asp 
145                 150                 155                 160 


Phe Leu Cys Pro Thr Asn Cys Pro Pro Gly Met Lys Gly Pro Pro Gly 
                165                 170                 175     


Leu Gln Gly Val Lys Gly His Ala Gly Lys Arg Gly Ile Leu Gly Asp 
            180                 185                 190         


Pro Gly His Gln Gly Lys Pro Gly Pro Lys Gly Asp Val Gly Ala Ser 
        195                 200                 205             


Gly Glu Gln Gly Ile Pro Gly Pro Pro Gly Pro Gln Gly Ile Arg Gly 
    210                 215                 220                 


Tyr Pro 
225     


<210>  76
<211>  694
<212>  PRT
<213>  Homo sapiens

<400>  76

Met Lys His Leu Lys Arg Trp Trp Ser Ala Gly Gly Gly Leu Leu His 
1               5                   10                  15      


Leu Thr Leu Leu Leu Ser Leu Ala Gly Leu Arg Val Asp Leu Asp Leu 
            20                  25                  30          


Tyr Leu Leu Leu Pro Pro Pro Thr Leu Leu Gln Asp Glu Leu Leu Phe 
        35                  40                  45              


Leu Gly Gly Pro Ala Ser Ser Ala Tyr Ala Leu Ser Pro Phe Ser Ala 
    50                  55                  60                  


Ser Gly Gly Trp Gly Arg Ala Gly His Leu His Pro Lys Gly Arg Glu 
65                  70                  75                  80  


Leu Asp Pro Ala Ala Pro Pro Glu Gly Gln Leu Leu Arg Glu Val Arg 
                85                  90                  95      


Ala Leu Gly Val Pro Phe Val Pro Arg Thr Ser Val Asp Ala Trp Leu 
            100                 105                 110         


Val His Ser Val Ala Ala Gly Ser Ala Asp Glu Ala His Gly Leu Leu 
        115                 120                 125             


Gly Ala Ala Ala Ala Ser Ser Thr Gly Gly Ala Gly Ala Ser Val Asp 
    130                 135                 140                 


Gly Gly Ser Gln Ala Val Gln Gly Gly Gly Gly Asp Pro Arg Ala Ala 
145                 150                 155                 160 


Arg Ser Gly Pro Leu Asp Ala Gly Glu Glu Glu Lys Ala Pro Ala Glu 
                165                 170                 175     


Pro Thr Ala Gln Val Pro Asp Ala Gly Gly Cys Ala Ser Glu Glu Asn 
            180                 185                 190         


Gly Val Leu Arg Glu Lys His Glu Ala Val Asp His Ser Ser Gln His 
        195                 200                 205             


Glu Glu Asn Glu Glu Arg Val Ser Ala Gln Lys Glu Asn Ser Leu Gln 
    210                 215                 220                 


Gln Asn Asp Asp Asp Glu Asn Lys Ile Ala Glu Lys Pro Asp Trp Glu 
225                 230                 235                 240 


Ala Glu Lys Thr Thr Glu Ser Arg Asn Glu Arg His Leu Asn Gly Thr 
                245                 250                 255     


Asp Thr Ser Phe Ser Leu Glu Asp Leu Phe Gln Leu Leu Ser Ser Gln 
            260                 265                 270         


Pro Glu Asn Ser Leu Glu Gly Ile Ser Leu Gly Asp Ile Pro Leu Pro 
        275                 280                 285             


Gly Ser Ile Ser Asp Gly Met Asn Ser Ser Ala His Tyr His Val Asn 
    290                 295                 300                 


Phe Ser Gln Ala Ile Ser Gln Asp Val Asn Leu His Glu Ala Ile Leu 
305                 310                 315                 320 


Leu Cys Pro Asn Asn Thr Phe Arg Arg Asp Pro Thr Ala Arg Thr Ser 
                325                 330                 335     


Gln Ser Gln Glu Pro Phe Leu Gln Leu Asn Ser His Thr Thr Asn Pro 
            340                 345                 350         


Glu Gln Thr Leu Pro Gly Thr Asn Leu Thr Gly Phe Leu Ser Pro Val 
        355                 360                 365             


Asp Asn His Met Arg Asn Leu Thr Ser Gln Asp Leu Leu Tyr Asp Leu 
    370                 375                 380                 


Asp Ile Asn Ile Phe Asp Glu Ile Asn Leu Met Ser Leu Ala Thr Glu 
385                 390                 395                 400 


Asp Asn Phe Asp Pro Ile Asp Val Ser Gln Leu Phe Asp Glu Pro Asp 
                405                 410                 415     


Ser Asp Ser Gly Leu Ser Leu Asp Ser Ser His Asn Asn Thr Ser Val 
            420                 425                 430         


Ile Lys Ser Asn Ser Ser His Ser Val Cys Asp Glu Gly Ala Ile Gly 
        435                 440                 445             


Tyr Cys Thr Asp His Glu Ser Ser Ser His His Asp Leu Glu Gly Ala 
    450                 455                 460                 


Val Gly Gly Tyr Tyr Pro Glu Pro Ser Lys Leu Cys His Leu Asp Gln 
465                 470                 475                 480 


Ser Asp Ser Asp Phe His Gly Asp Leu Thr Phe Gln His Val Phe His 
                485                 490                 495     


Asn His Thr Tyr His Leu Gln Pro Thr Ala Pro Glu Ser Thr Ser Glu 
            500                 505                 510         


Pro Phe Pro Trp Pro Gly Lys Ser Gln Lys Ile Arg Ser Arg Tyr Leu 
        515                 520                 525             


Glu Asp Thr Asp Arg Asn Leu Ser Arg Asp Glu Gln Arg Ala Lys Ala 
    530                 535                 540                 


Leu His Ile Pro Phe Ser Val Asp Glu Ile Val Gly Met Pro Val Asp 
545                 550                 555                 560 


Ser Phe Asn Ser Met Leu Ser Arg Tyr Tyr Leu Thr Asp Leu Gln Val 
                565                 570                 575     


Ser Leu Ile Arg Asp Ile Arg Arg Arg Gly Lys Asn Lys Val Ala Ala 
            580                 585                 590         


Gln Asn Cys Arg Lys Arg Lys Leu Asp Ile Ile Leu Asn Leu Glu Asp 
        595                 600                 605             


Asp Val Cys Asn Leu Gln Ala Lys Lys Glu Thr Leu Lys Arg Glu Gln 
    610                 615                 620                 


Ala Gln Cys Asn Lys Ala Ile Asn Ile Met Lys Gln Lys Leu His Asp 
625                 630                 635                 640 


Leu Tyr His Asp Ile Phe Ser Arg Leu Arg Asp Asp Gln Gly Arg Pro 
                645                 650                 655     


Val Asn Pro Asn His Tyr Ala Leu Gln Cys Thr His Asp Gly Ser Ile 
            660                 665                 670         


Leu Ile Val Pro Lys Glu Leu Val Ala Ser Gly His Lys Lys Glu Thr 
        675                 680                 685             


Gln Lys Gly Lys Arg Lys 
    690                 


<210>  77
<211>  86
<212>  PRT
<213>  Homo sapiens

<400>  77

Cys Asn Cys Gly Leu Val Phe His Leu Gln Asp Pro Trp Val Pro Thr 
1               5                   10                  15      


Gly Pro Gly Ala Val Gln Lys Gln Arg Glu His Pro Pro Asp Tyr Gln 
            20                  25                  30          


Trp Tyr Ala Leu Asp Gln Leu Pro Pro Asp Val Gln His Lys Ala Asn 
        35                  40                  45              


Glu Ser Ala Ile Leu Ser Thr Ala Cys Phe Tyr Gly Leu Val Arg Pro 
    50                  55                  60                  


Pro Arg Ser Gly Leu Tyr Lys Leu Ser Tyr Asn Gln Asn Pro Thr Ser 
65                  70                  75                  80  


Ile Leu Ile Lys Tyr Thr 
                85      


<210>  78
<211>  1722
<212>  PRT
<213>  Homo sapiens

<400>  78

Met Arg Thr Gly Trp Ala Thr Pro Arg Arg Pro Ala Gly Leu Leu Met 
1               5                   10                  15      


Leu Leu Phe Trp Phe Phe Asp Leu Ala Glu Pro Ser Gly Arg Ala Ala 
            20                  25                  30          


Asn Asp Pro Phe Thr Ile Val His Gly Asn Thr Gly Lys Cys Ile Lys 
        35                  40                  45              


Pro Val Tyr Gly Trp Ile Val Ala Asp Asp Cys Asp Glu Thr Glu Asp 
    50                  55                  60                  


Lys Leu Trp Lys Trp Val Ser Gln His Arg Leu Phe His Leu His Ser 
65                  70                  75                  80  


Gln Lys Cys Leu Gly Leu Asp Ile Thr Lys Ser Val Asn Glu Leu Arg 
                85                  90                  95      


Met Phe Ser Cys Asp Ser Ser Ala Met Leu Trp Trp Lys Cys Glu His 
            100                 105                 110         


His Ser Leu Tyr Gly Ala Ala Arg Tyr Arg Leu Ala Leu Lys Asp Gly 
        115                 120                 125             


His Gly Thr Ala Ile Ser Asn Ala Ser Asp Val Trp Lys Lys Gly Gly 
    130                 135                 140                 


Ser Glu Glu Ser Leu Cys Asp Gln Pro Tyr His Glu Ile Tyr Thr Arg 
145                 150                 155                 160 


Asp Gly Asn Ser Tyr Gly Arg Pro Cys Glu Phe Pro Phe Leu Ile Asp 
                165                 170                 175     


Gly Thr Trp His His Asp Cys Ile Leu Asp Glu Asp His Ser Gly Pro 
            180                 185                 190         


Trp Cys Ala Thr Thr Leu Asn Tyr Glu Tyr Asp Arg Lys Trp Gly Ile 
        195                 200                 205             


Cys Leu Lys Pro Glu Asn Gly Cys Glu Asp Asn Trp Glu Lys Asn Glu 
    210                 215                 220                 


Gln Phe Gly Ser Cys Tyr Gln Phe Asn Thr Gln Thr Ala Leu Ser Trp 
225                 230                 235                 240 


Lys Glu Ala Tyr Val Ser Cys Gln Asn Gln Gly Ala Asp Leu Leu Ser 
                245                 250                 255     


Ile Asn Ser Ala Ala Glu Leu Thr Tyr Leu Lys Glu Lys Glu Gly Ile 
            260                 265                 270         


Ala Lys Ile Phe Trp Ile Gly Leu Asn Gln Leu Tyr Ser Ala Arg Gly 
        275                 280                 285             


Trp Glu Trp Ser Asp His Lys Pro Leu Asn Phe Leu Asn Trp Asp Pro 
    290                 295                 300                 


Asp Arg Pro Ser Ala Pro Thr Ile Gly Gly Ser Ser Cys Ala Arg Met 
305                 310                 315                 320 


Asp Ala Glu Ser Gly Leu Trp Gln Ser Phe Ser Cys Glu Ala Gln Leu 
                325                 330                 335     


Pro Tyr Val Cys Arg Lys Pro Leu Asn Asn Thr Val Glu Leu Thr Asp 
            340                 345                 350         


Val Trp Thr Tyr Ser Asp Thr Arg Cys Asp Ala Gly Trp Leu Pro Asn 
        355                 360                 365             


Asn Gly Phe Cys Tyr Leu Leu Val Asn Glu Ser Asn Ser Trp Asp Lys 
    370                 375                 380                 


Ala His Ala Lys Cys Lys Ala Phe Ser Ser Asp Leu Ile Ser Ile His 
385                 390                 395                 400 


Ser Leu Ala Asp Val Glu Val Val Val Thr Lys Leu His Asn Glu Asp 
                405                 410                 415     


Ile Lys Glu Glu Val Trp Ile Gly Leu Lys Asn Ile Asn Ile Pro Thr 
            420                 425                 430         


Leu Phe Gln Trp Ser Asp Gly Thr Glu Val Thr Leu Thr Tyr Trp Asp 
        435                 440                 445             


Glu Asn Glu Pro Asn Val Pro Tyr Asn Lys Thr Pro Asn Cys Val Ser 
    450                 455                 460                 


Tyr Leu Gly Glu Leu Gly Gln Trp Lys Val Gln Ser Cys Glu Glu Lys 
465                 470                 475                 480 


Leu Lys Tyr Val Cys Lys Arg Lys Gly Glu Lys Leu Asn Asp Ala Ser 
                485                 490                 495     


Ser Asp Lys Met Cys Pro Pro Asp Glu Gly Trp Lys Arg His Gly Glu 
            500                 505                 510         


Thr Cys Tyr Lys Ile Tyr Glu Asp Glu Val Pro Phe Gly Thr Asn Cys 
        515                 520                 525             


Asn Leu Thr Ile Thr Ser Arg Phe Glu Gln Glu Tyr Leu Asn Asp Leu 
    530                 535                 540                 


Met Lys Lys Tyr Asp Lys Ser Leu Arg Lys Tyr Phe Trp Thr Gly Leu 
545                 550                 555                 560 


Arg Asp Val Asp Ser Cys Gly Glu Tyr Asn Trp Ala Thr Val Gly Gly 
                565                 570                 575     


Arg Arg Arg Ala Val Thr Phe Ser Asn Trp Asn Phe Leu Glu Pro Ala 
            580                 585                 590         


Ser Pro Gly Gly Cys Val Ala Met Ser Thr Gly Lys Ser Val Gly Lys 
        595                 600                 605             


Trp Glu Val Lys Asp Cys Arg Ser Phe Lys Ala Leu Ser Ile Cys Lys 
    610                 615                 620                 


Lys Met Ser Gly Pro Leu Gly Pro Glu Glu Ala Ser Pro Lys Pro Asp 
625                 630                 635                 640 


Asp Pro Cys Pro Glu Gly Trp Gln Ser Phe Pro Ala Ser Leu Ser Cys 
                645                 650                 655     


Tyr Lys Val Phe His Ala Glu Arg Ile Val Arg Lys Arg Asn Trp Glu 
            660                 665                 670         


Glu Ala Glu Arg Phe Cys Gln Ala Leu Gly Ala His Leu Ser Ser Phe 
        675                 680                 685             


Ser His Val Asp Glu Ile Lys Glu Phe Leu His Phe Leu Thr Asp Gln 
    690                 695                 700                 


Phe Ser Gly Gln His Trp Leu Trp Ile Gly Leu Asn Lys Arg Ser Pro 
705                 710                 715                 720 


Asp Leu Gln Gly Ser Trp Gln Trp Ser Asp Arg Thr Pro Val Ser Thr 
                725                 730                 735     


Ile Ile Met Pro Asn Glu Phe Gln Gln Asp Tyr Asp Ile Arg Asp Cys 
            740                 745                 750         


Ala Ala Val Lys Val Phe His Arg Pro Trp Arg Arg Gly Trp His Phe 
        755                 760                 765             


Tyr Asp Asp Arg Glu Phe Ile Tyr Leu Arg Pro Phe Ala Cys Asp Thr 
    770                 775                 780                 


Lys Leu Glu Trp Val Cys Gln Ile Pro Lys Gly Arg Thr Pro Lys Thr 
785                 790                 795                 800 


Pro Asp Trp Tyr Asn Pro Asp Arg Ala Gly Ile His Gly Pro Pro Leu 
                805                 810                 815     


Ile Ile Glu Gly Ser Glu Tyr Trp Phe Val Ala Asp Leu His Leu Asn 
            820                 825                 830         


Tyr Glu Glu Ala Val Leu Tyr Cys Ala Ser Asn His Ser Phe Leu Ala 
        835                 840                 845             


Thr Ile Thr Ser Phe Val Gly Leu Lys Ala Ile Lys Asn Lys Ile Ala 
    850                 855                 860                 


Asn Ile Ser Gly Asp Gly Gln Lys Trp Trp Ile Arg Ile Ser Glu Trp 
865                 870                 875                 880 


Pro Ile Asp Asp His Phe Thr Tyr Ser Arg Tyr Pro Trp His Arg Phe 
                885                 890                 895     


Pro Val Thr Phe Gly Glu Glu Cys Leu Tyr Met Ser Ala Lys Thr Trp 
            900                 905                 910         


Leu Ile Asp Leu Gly Lys Pro Thr Asp Cys Ser Thr Lys Leu Pro Phe 
        915                 920                 925             


Ile Cys Glu Lys Tyr Asn Val Ser Ser Leu Glu Lys Tyr Ser Pro Asp 
    930                 935                 940                 


Ser Ala Ala Lys Val Gln Cys Ser Glu Gln Trp Ile Pro Phe Gln Asn 
945                 950                 955                 960 


Lys Cys Phe Leu Lys Ile Lys Pro Val Ser Leu Thr Phe Ser Gln Ala 
                965                 970                 975     


Ser Asp Thr Cys His Ser Tyr Gly Gly Thr Leu Pro Ser Val Leu Ser 
            980                 985                 990         


Gln Ile Glu Gln Asp Phe Ile Thr  Ser Leu Leu Pro Asp  Met Glu Ala 
        995                 1000                 1005             


Thr Leu  Trp Ile Gly Leu Arg  Trp Thr Ala Tyr Glu  Lys Ile Asn 
    1010                 1015                 1020             


Lys Trp  Thr Asp Asn Arg Glu  Leu Thr Tyr Ser Asn  Phe His Pro 
    1025                 1030                 1035             


Leu Leu  Val Ser Gly Arg Leu  Arg Ile Pro Glu Asn  Phe Phe Glu 
    1040                 1045                 1050             


Glu Glu  Ser Arg Tyr His Cys  Ala Leu Ile Leu Asn  Leu Gln Lys 
    1055                 1060                 1065             


Ser Pro  Phe Thr Gly Thr Trp  Asn Phe Thr Ser Cys  Ser Glu Arg 
    1070                 1075                 1080             


His Phe  Val Ser Leu Cys Gln  Lys Tyr Ser Glu Val  Lys Ser Arg 
    1085                 1090                 1095             


Gln Thr  Leu Gln Asn Ala Ser  Glu Thr Val Lys Tyr  Leu Asn Asn 
    1100                 1105                 1110             


Leu Tyr  Lys Ile Ile Pro Lys  Thr Leu Thr Trp His  Ser Ala Lys 
    1115                 1120                 1125             


Arg Glu  Cys Leu Lys Ser Asn  Met Gln Leu Val Ser  Ile Thr Asp 
    1130                 1135                 1140             


Pro Tyr  Gln Gln Ala Phe Leu  Ser Val Gln Ala Leu  Leu His Asn 
    1145                 1150                 1155             


Ser Ser  Leu Trp Ile Gly Leu  Phe Ser Gln Asp Asp  Glu Leu Asn 
    1160                 1165                 1170             


Phe Gly  Trp Ser Asp Gly Lys  Arg Leu His Phe Ser  Arg Trp Ala 
    1175                 1180                 1185             


Glu Thr  Asn Gly Gln Leu Glu  Asp Cys Val Val Leu  Asp Thr Asp 
    1190                 1195                 1200             


Gly Phe  Trp Lys Thr Val Asp  Cys Asn Asp Asn Gln  Pro Gly Ala 
    1205                 1210                 1215             


Ile Cys  Tyr Tyr Ser Gly Asn  Glu Thr Glu Lys Glu  Val Lys Pro 
    1220                 1225                 1230             


Val Asp  Ser Val Lys Cys Pro  Ser Pro Val Leu Asn  Thr Pro Trp 
    1235                 1240                 1245             


Ile Pro  Phe Gln Asn Cys Cys  Tyr Asn Phe Ile Ile  Thr Lys Asn 
    1250                 1255                 1260             


Arg His  Met Ala Thr Thr Gln  Asp Glu Val His Thr  Lys Cys Gln 
    1265                 1270                 1275             


Lys Leu  Asn Pro Lys Ser His  Ile Leu Ser Ile Arg  Asp Glu Lys 
    1280                 1285                 1290             


Glu Asn  Asn Phe Val Leu Glu  Gln Leu Leu Tyr Phe  Asn Tyr Met 
    1295                 1300                 1305             


Ala Ser  Trp Val Met Leu Gly  Ile Thr Tyr Arg Asn  Lys Ser Leu 
    1310                 1315                 1320             


Met Trp  Phe Asp Lys Thr Pro  Leu Ser Tyr Thr His  Trp Arg Ala 
    1325                 1330                 1335             


Gly Arg  Pro Thr Ile Lys Asn  Glu Lys Phe Leu Ala  Gly Leu Ser 
    1340                 1345                 1350             


Thr Asp  Gly Phe Trp Asp Ile  Gln Thr Phe Lys Val  Ile Glu Glu 
    1355                 1360                 1365             


Ala Val  Tyr Phe His Gln His  Ser Ile Leu Ala Cys  Lys Ile Glu 
    1370                 1375                 1380             


Met Val  Asp Tyr Lys Glu Glu  Tyr Asn Thr Thr Leu  Pro Gln Phe 
    1385                 1390                 1395             


Met Pro  Tyr Glu Asp Gly Ile  Tyr Ser Val Ile Gln  Lys Lys Val 
    1400                 1405                 1410             


Thr Trp  Tyr Glu Ala Leu Asn  Met Cys Ser Gln Ser  Gly Gly His 
    1415                 1420                 1425             


Leu Ala  Ser Val His Asn Gln  Asn Gly Gln Leu Phe  Leu Glu Asp 
    1430                 1435                 1440             


Ile Val  Lys Arg Asp Gly Phe  Pro Leu Trp Val Gly  Leu Ser Ser 
    1445                 1450                 1455             


His Asp  Gly Ser Glu Ser Ser  Phe Glu Trp Ser Asp  Gly Ser Thr 
    1460                 1465                 1470             


Phe Asp  Tyr Ile Pro Trp Lys  Gly Gln Thr Ser Pro  Gly Asn Cys 
    1475                 1480                 1485             


Val Leu  Leu Asp Pro Lys Gly  Thr Trp Lys His Glu  Lys Cys Asn 
    1490                 1495                 1500             


Ser Val  Lys Asp Gly Ala Ile  Cys Tyr Lys Pro Thr  Lys Ser Lys 
    1505                 1510                 1515             


Lys Leu  Ser Arg Leu Thr Tyr  Ser Ser Arg Cys Pro  Ala Ala Lys 
    1520                 1525                 1530             


Glu Asn  Gly Ser Arg Trp Ile  Gln Tyr Lys Gly His  Cys Tyr Lys 
    1535                 1540                 1545             


Ser Asp  Gln Ala Leu His Ser  Phe Ser Glu Ala Lys  Lys Leu Cys 
    1550                 1555                 1560             


Ser Lys  His Asp His Ser Ala  Thr Ile Val Ser Ile  Lys Asp Glu 
    1565                 1570                 1575             


Asp Glu  Asn Lys Phe Val Ser  Arg Leu Met Arg Glu  Asn Asn Asn 
    1580                 1585                 1590             


Ile Thr  Met Arg Val Trp Leu  Gly Leu Ser Gln His  Ser Val Asp 
    1595                 1600                 1605             


Gln Ser  Trp Ser Trp Leu Asp  Gly Ser Glu Val Thr  Phe Val Lys 
    1610                 1615                 1620             


Trp Glu  Asn Lys Ser Lys Ser  Gly Val Gly Arg Cys  Ser Met Leu 
    1625                 1630                 1635             


Ile Ala  Ser Asn Glu Thr Trp  Lys Lys Val Glu Cys  Glu His Gly 
    1640                 1645                 1650             


Phe Gly  Arg Val Val Cys Lys  Val Pro Leu Gly Pro  Asp Tyr Thr 
    1655                 1660                 1665             


Ala Ile  Ala Ile Ile Val Ala  Thr Leu Ser Ile Leu  Val Leu Met 
    1670                 1675                 1680             


Gly Gly  Leu Ile Trp Phe Leu  Phe Gln Arg His Arg  Leu His Leu 
    1685                 1690                 1695             


Ala Gly  Phe Ser Ser Val Arg  Tyr Ala Gln Gly Val  Asn Glu Asp 
    1700                 1705                 1710             


Glu Ile  Met Leu Pro Ser Phe  His Asp 
    1715                 1720         


<210>  79
<211>  306
<212>  PRT
<213>  Homo sapiens

<400>  79

Met Ala Ala Val Asp Asp Leu Gln Phe Glu Glu Phe Gly Asn Ala Ala 
1               5                   10                  15      


Thr Ser Leu Thr Ala Asn Pro Asp Ala Thr Thr Val Asn Ile Glu Asp 
            20                  25                  30          


Pro Gly Glu Thr Pro Lys His Gln Pro Gly Ser Pro Arg Gly Ser Gly 
        35                  40                  45              


Arg Glu Glu Asp Asp Glu Leu Leu Gly Asn Asp Asp Ser Asp Lys Thr 
    50                  55                  60                  


Glu Leu Leu Ala Gly Gln Lys Lys Ser Ser Pro Phe Trp Thr Phe Glu 
65                  70                  75                  80  


Tyr Tyr Gln Thr Phe Phe Asp Val Asp Thr Tyr Gln Val Phe Asp Arg 
                85                  90                  95      


Ile Lys Gly Ser Leu Leu Pro Ile Pro Gly Lys Asn Phe Val Arg Leu 
            100                 105                 110         


Tyr Ile Arg Ser Asn Pro Asp Leu Tyr Gly Pro Phe Trp Ile Cys Ala 
        115                 120                 125             


Thr Leu Val Phe Ala Ile Ala Ile Ser Gly Asn Leu Ser Asn Phe Leu 
    130                 135                 140                 


Ile His Leu Gly Glu Lys Thr Tyr His Tyr Val Pro Glu Phe Arg Lys 
145                 150                 155                 160 


Val Ser Ile Ala Ala Thr Ile Ile Tyr Ala Tyr Ala Trp Leu Val Pro 
                165                 170                 175     


Leu Ala Leu Trp Gly Phe Leu Met Trp Arg Asn Ser Lys Val Met Asn 
            180                 185                 190         


Ile Val Ser Tyr Ser Phe Leu Glu Ile Val Cys Val Tyr Gly Tyr Ser 
        195                 200                 205             


Leu Phe Ile Tyr Ile Pro Thr Ala Ile Leu Trp Ile Ile Pro Gln Lys 
    210                 215                 220                 


Ala Val Arg Trp Ile Leu Val Met Ile Ala Leu Gly Ile Ser Gly Ser 
225                 230                 235                 240 


Leu Leu Ala Met Thr Phe Trp Pro Ala Val Arg Glu Asp Asn Arg Arg 
                245                 250                 255     


Val Ala Leu Ala Thr Ile Val Thr Ile Val Leu Leu His Met Leu Leu 
            260                 265                 270         


Ser Val Gly Cys Leu Ala Tyr Phe Phe Asp Ala Pro Glu Met Asp His 
        275                 280                 285             


Leu Pro Thr Thr Thr Ala Thr Pro Asn Gln Thr Val Ala Ala Ala Lys 
    290                 295                 300                 


Ser Ser 
305     


<210>  80
<211>  123
<212>  PRT
<213>  Homo sapiens

<400>  80

Met Trp Arg Asn Ser Lys Val Met Asn Ile Val Ser Tyr Ser Phe Leu 
1               5                   10                  15      


Glu Ile Val Cys Val Tyr Gly Tyr Ser Leu Phe Ile Tyr Ile Pro Thr 
            20                  25                  30          


Ala Ile Leu Trp Ile Ile Pro Gln Lys Ala Val Arg Trp Ile Leu Val 
        35                  40                  45              


Met Ile Ala Leu Gly Ile Ser Gly Ser Leu Leu Ala Met Thr Phe Trp 
    50                  55                  60                  


Pro Ala Val Arg Glu Asp Asn Arg Arg Val Ala Leu Ala Thr Ile Val 
65                  70                  75                  80  


Thr Ile Val Leu Leu His Met Leu Leu Ser Val Gly Cys Leu Ala Tyr 
                85                  90                  95      


Phe Phe Asp Ala Pro Glu Met Asp His Leu Pro Thr Thr Thr Ala Thr 
            100                 105                 110         


Pro Asn Gln Thr Val Ala Ala Ala Lys Ser Ser 
        115                 120             


<210>  81
<211>  217
<212>  PRT
<213>  Homo sapiens

<400>  81

Met Ala Ala Val Asp Asp Leu Gln Phe Glu Glu Phe Gly Asn Ala Ala 
1               5                   10                  15      


Thr Ser Leu Thr Ala Asn Pro Asp Ala Thr Thr Val Asn Ile Glu Asp 
            20                  25                  30          


Pro Gly Glu Thr Pro Lys His Gln Pro Gly Ser Pro Arg Gly Ser Gly 
        35                  40                  45              


Arg Glu Glu Asp Asp Glu Leu Leu Gly Asn Asp Asp Ser Asp Lys Thr 
    50                  55                  60                  


Glu Leu Leu Ala Gly Gln Lys Lys Ser Ser Pro Phe Trp Thr Phe Glu 
65                  70                  75                  80  


Tyr Tyr Gln Thr Phe Phe Asp Val Asp Thr Tyr Gln Val Phe Asp Arg 
                85                  90                  95      


Ile Lys Gly Ser Leu Leu Pro Ile Pro Gly Lys Asn Phe Val Arg Leu 
            100                 105                 110         


Tyr Ile Arg Ser Asn Pro Asp Leu Tyr Gly Pro Phe Trp Ile Cys Ala 
        115                 120                 125             


Thr Leu Val Phe Ala Ile Ala Ile Ser Gly Asn Leu Ser Asn Phe Leu 
    130                 135                 140                 


Ile His Leu Gly Glu Lys Thr Tyr His Tyr Val Pro Glu Phe Arg Lys 
145                 150                 155                 160 


Val Ser Ile Ala Ala Thr Ile Ile Tyr Ala Tyr Ala Trp Leu Val Pro 
                165                 170                 175     


Leu Ala Leu Trp Gly Phe Leu Met Trp Arg Asn Ser Lys Val Met Asn 
            180                 185                 190         


Ile Val Ser Tyr Ser Phe Leu Glu Ile Val Cys Val Tyr Gly Tyr Ser 
        195                 200                 205             


Leu Phe Ile Tyr Ile Pro Thr Ala Val 
    210                 215         


<210>  82
<211>  306
<212>  PRT
<213>  Homo sapiens

<400>  82

Met Ala Ala Val Asp Asp Leu Gln Phe Glu Glu Phe Gly Asn Ala Ala 
1               5                   10                  15      


Thr Ser Leu Thr Ala Asn Pro Asp Ala Thr Thr Val Asn Ile Glu Asp 
            20                  25                  30          


Pro Gly Glu Thr Pro Lys His Gln Pro Gly Ser Pro Arg Gly Ser Gly 
        35                  40                  45              


Arg Glu Glu Asp Asp Glu Leu Leu Gly Asn Asp Asp Ser Asp Lys Thr 
    50                  55                  60                  


Glu Leu Leu Ala Gly Gln Lys Lys Ser Ser Pro Phe Trp Thr Phe Glu 
65                  70                  75                  80  


Tyr Tyr Gln Thr Phe Phe Asp Val Asp Thr Tyr Gln Val Phe Asp Arg 
                85                  90                  95      


Ile Lys Gly Ser Leu Leu Pro Ile Pro Gly Lys Asn Phe Val Arg Leu 
            100                 105                 110         


Tyr Ile Arg Ser Asn Pro Asp Leu Tyr Gly Pro Phe Trp Ile Cys Ala 
        115                 120                 125             


Thr Leu Val Phe Ala Ile Ala Ile Ser Gly Asn Leu Ser Asn Phe Leu 
    130                 135                 140                 


Ile His Leu Gly Glu Lys Thr Tyr His Tyr Val Pro Glu Phe Arg Lys 
145                 150                 155                 160 


Val Ser Ile Ala Ala Thr Ile Ile Tyr Ala Tyr Ala Trp Leu Val Pro 
                165                 170                 175     


Leu Ala Leu Trp Gly Phe Leu Met Trp Arg Asn Ser Lys Val Met Asn 
            180                 185                 190         


Ile Val Ser Tyr Ser Phe Leu Glu Ile Val Cys Val Tyr Gly Tyr Ser 
        195                 200                 205             


Leu Phe Ile Tyr Ile Pro Thr Ala Ile Leu Trp Ile Ile Pro Gln Lys 
    210                 215                 220                 


Ala Val Arg Trp Ile Leu Val Met Ile Ala Leu Gly Ile Ser Gly Ser 
225                 230                 235                 240 


Leu Leu Ala Met Thr Phe Trp Pro Ala Val Arg Glu Asp Asn Arg Arg 
                245                 250                 255     


Val Ala Leu Ala Thr Ile Val Thr Ile Val Leu Leu His Met Leu Leu 
            260                 265                 270         


Ser Val Gly Cys Leu Ala Tyr Phe Phe Asp Ala Pro Glu Met Asp His 
        275                 280                 285             


Leu Pro Thr Thr Thr Ala Thr Pro Asn Gln Thr Val Ala Ala Ala Lys 
    290                 295                 300                 


Ser Ser 
305     


<210>  83
<211>  298
<212>  PRT
<213>  Homo sapiens

<400>  83

Met Ala Ala Ala Glu Pro Ala Val Leu Ala Leu Pro Asn Ser Gly Ala 
1               5                   10                  15      


Gly Gly Ala Gly Ala Pro Ser Gly Thr Val Pro Val Leu Phe Cys Phe 
            20                  25                  30          


Ser Val Phe Ala Arg Pro Ser Ser Val Pro His Gly Ala Gly Tyr Glu 
        35                  40                  45              


Leu Leu Ile Gln Lys Phe Leu Ser Leu Tyr Gly Asp Gln Ile Asp Met 
    50                  55                  60                  


His Arg Lys Phe Val Val Gln Leu Phe Ala Glu Glu Trp Gly Gln Tyr 
65                  70                  75                  80  


Val Asp Leu Pro Lys Gly Phe Ala Val Ser Glu Arg Cys Lys Val Arg 
                85                  90                  95      


Leu Val Pro Leu Gln Ile Gln Leu Thr Thr Leu Gly Asn Leu Thr Pro 
            100                 105                 110         


Ser Ser Thr Val Phe Phe Cys Cys Asp Met Gln Glu Arg Phe Arg Pro 
        115                 120                 125             


Ala Ile Lys Tyr Phe Gly Asp Ile Ile Ser Val Gly Gln Arg Leu Leu 
    130                 135                 140                 


Gln Gly Ala Arg Ile Leu Gly Ile Pro Val Ile Val Thr Glu Gln Tyr 
145                 150                 155                 160 


Pro Lys Gly Leu Gly Ser Thr Val Gln Glu Ile Asp Leu Thr Gly Val 
                165                 170                 175     


Lys Leu Val Leu Pro Lys Thr Lys Phe Ser Met Val Leu Pro Glu Val 
            180                 185                 190         


Glu Ala Ala Leu Ala Glu Ile Pro Gly Val Arg Ser Val Val Leu Phe 
        195                 200                 205             


Gly Val Glu Thr His Val Cys Ile Gln Gln Thr Ala Leu Glu Leu Val 
    210                 215                 220                 


Gly Arg Gly Val Glu Val His Ile Val Ala Asp Ala Thr Ser Ser Arg 
225                 230                 235                 240 


Ser Met Met Asp Arg Met Phe Ala Leu Glu Arg Leu Ala Arg Thr Gly 
                245                 250                 255     


Ile Ile Val Thr Thr Ser Glu Ala Val Leu Leu Gln Leu Val Ala Asp 
            260                 265                 270         


Lys Asp His Pro Lys Phe Lys Glu Ile Gln Asn Leu Ile Lys Ala Ser 
        275                 280                 285             


Ala Pro Glu Ser Gly Leu Leu Ser Lys Val 
    290                 295             


<210>  84
<211>  188
<212>  PRT
<213>  Homo sapiens

<400>  84

Met Ala Ala Ala Glu Pro Ala Val Leu Ala Leu Pro Asn Ser Gly Ala 
1               5                   10                  15      


Gly Gly Ala Gly Ala Pro Ser Gly Thr Val Pro Val Leu Phe Cys Phe 
            20                  25                  30          


Ser Val Phe Ala Arg Pro Ser Ser Val Pro His Gly Ala Gly Tyr Glu 
        35                  40                  45              


Leu Leu Ile Gln Lys Phe Leu Ser Leu Tyr Gly Asp Gln Ile Asp Met 
    50                  55                  60                  


His Arg Lys Phe Val Val Gln Leu Phe Ala Glu Glu Trp Gly Gln Tyr 
65                  70                  75                  80  


Val Asp Leu Pro Lys Gly Phe Ala Val Ser Glu Arg Cys Lys Leu Thr 
                85                  90                  95      


Thr Leu Gly Asn Leu Thr Pro Ser Ser Thr Val Phe Phe Cys Cys Asp 
            100                 105                 110         


Met Gln Glu Arg Phe Arg Pro Ala Ile Lys Tyr Phe Gly Asp Ile Ile 
        115                 120                 125             


Ser Val Gly Gln Arg Leu Leu Gln Gly Ala Arg Ile Leu Gly Ile Pro 
    130                 135                 140                 


Val Ile Val Thr Glu Gln Tyr Pro Lys Gly Leu Gly Ser Thr Val Gln 
145                 150                 155                 160 


Glu Ile Asp Leu Thr Gly Val Lys Leu Val Leu Pro Lys Thr Lys Phe 
                165                 170                 175     


Ser Met Val Leu Pro Glu Val Glu Ala Ala Leu Ala 
            180                 185             


<210>  85
<211>  711
<212>  PRT
<213>  Homo sapiens

<400>  85

Met Lys Leu Lys Leu Asn Val Leu Thr Ile Ile Leu Leu Pro Val His 
1               5                   10                  15      


Leu Leu Ile Thr Ile Tyr Ser Ala Leu Ile Phe Ile Pro Trp Tyr Phe 
            20                  25                  30          


Leu Thr Asn Ala Lys Lys Lys Asn Ala Met Ala Lys Arg Ile Lys Ala 
        35                  40                  45              


Lys Pro Thr Ser Asp Lys Pro Gly Ser Pro Tyr Arg Ser Val Thr His 
    50                  55                  60                  


Phe Asp Ser Leu Ala Val Ile Asp Ile Pro Gly Ala Asp Thr Leu Asp 
65                  70                  75                  80  


Lys Leu Phe Asp His Ala Val Ser Lys Phe Gly Lys Lys Asp Ser Leu 
                85                  90                  95      


Gly Thr Arg Glu Ile Leu Ser Glu Glu Asn Glu Met Gln Pro Asn Gly 
            100                 105                 110         


Lys Val Phe Lys Lys Leu Ile Leu Gly Asn Tyr Lys Trp Met Asn Tyr 
        115                 120                 125             


Leu Glu Val Asn Arg Arg Val Asn Asn Phe Gly Ser Gly Leu Thr Ala 
    130                 135                 140                 


Leu Gly Leu Lys Pro Lys Asn Thr Ile Ala Ile Phe Cys Glu Thr Arg 
145                 150                 155                 160 


Ala Glu Trp Met Ile Ala Ala Gln Thr Cys Phe Lys Tyr Asn Phe Pro 
                165                 170                 175     


Leu Val Thr Leu Tyr Ala Thr Leu Gly Lys Glu Ala Val Val His Gly 
            180                 185                 190         


Leu Asn Glu Ser Glu Ala Ser Tyr Leu Ile Thr Ser Val Glu Leu Leu 
        195                 200                 205             


Glu Ser Lys Leu Lys Thr Ala Leu Leu Asp Ile Ser Cys Val Lys His 
    210                 215                 220                 


Ile Ile Tyr Val Asp Asn Lys Ala Ile Asn Lys Ala Glu Tyr Pro Glu 
225                 230                 235                 240 


Gly Phe Glu Ile His Ser Met Gln Ser Val Glu Glu Leu Gly Ser Asn 
                245                 250                 255     


Pro Glu Asn Leu Gly Ile Pro Pro Ser Arg Pro Thr Pro Ser Asp Met 
            260                 265                 270         


Ala Ile Val Met Tyr Thr Ser Gly Ser Thr Gly Arg Pro Lys Gly Val 
        275                 280                 285             


Met Met His His Ser Asn Leu Ile Ala Gly Met Thr Gly Gln Cys Glu 
    290                 295                 300                 


Arg Ile Pro Gly Leu Gly Pro Lys Asp Thr Tyr Ile Gly Tyr Leu Pro 
305                 310                 315                 320 


Leu Ala His Val Leu Glu Leu Thr Ala Glu Ile Ser Cys Phe Thr Tyr 
                325                 330                 335     


Gly Cys Arg Ile Gly Tyr Ser Ser Pro Leu Thr Leu Ser Asp Gln Ser 
            340                 345                 350         


Ser Lys Ile Lys Lys Gly Ser Lys Gly Asp Cys Thr Val Leu Lys Pro 
        355                 360                 365             


Thr Leu Met Ala Ala Val Pro Glu Ile Met Asp Arg Ile Tyr Lys Asn 
    370                 375                 380                 


Val Met Ser Lys Val Gln Glu Met Asn Tyr Ile Gln Lys Thr Leu Phe 
385                 390                 395                 400 


Lys Ile Gly Tyr Asp Tyr Lys Leu Glu Gln Ile Lys Lys Gly Tyr Asp 
                405                 410                 415     


Ala Pro Leu Cys Asn Leu Leu Leu Phe Lys Lys Val Lys Ala Leu Leu 
            420                 425                 430         


Gly Gly Asn Val Arg Met Met Leu Ser Gly Gly Ala Pro Leu Ser Pro 
        435                 440                 445             


Gln Thr His Arg Phe Met Asn Val Cys Phe Cys Cys Pro Ile Gly Gln 
    450                 455                 460                 


Gly Tyr Gly Leu Thr Glu Ser Cys Gly Ala Gly Thr Val Thr Glu Val 
465                 470                 475                 480 


Thr Asp Tyr Thr Thr Gly Arg Val Gly Ala Pro Leu Ile Cys Cys Glu 
                485                 490                 495     


Ile Lys Leu Lys Asp Trp Gln Glu Gly Gly Tyr Thr Ile Asn Asp Lys 
            500                 505                 510         


Pro Asn Pro Arg Gly Glu Ile Val Ile Gly Gly Gln Asn Ile Ser Met 
        515                 520                 525             


Gly Tyr Phe Lys Asn Glu Glu Lys Thr Ala Glu Asp Tyr Ser Val Asp 
    530                 535                 540                 


Glu Asn Gly Gln Arg Trp Phe Cys Thr Gly Asp Ile Gly Glu Phe His 
545                 550                 555                 560 


Pro Asp Gly Cys Leu Gln Ile Ile Asp Arg Lys Lys Asp Leu Val Lys 
                565                 570                 575     


Leu Gln Ala Gly Glu Tyr Val Ser Leu Gly Lys Val Glu Ala Ala Leu 
            580                 585                 590         


Lys Asn Cys Pro Leu Ile Asp Asn Ile Cys Ala Phe Ala Lys Ser Asp 
        595                 600                 605             


Gln Ser Tyr Val Ile Ser Phe Val Val Pro Asn Gln Lys Arg Leu Thr 
    610                 615                 620                 


Leu Leu Ala Gln Gln Lys Gly Val Glu Gly Thr Trp Val Asp Ile Cys 
625                 630                 635                 640 


Asn Asn Pro Ala Met Glu Ala Glu Ile Leu Lys Glu Ile Arg Glu Ala 
                645                 650                 655     


Ala Asn Ala Met Lys Leu Glu Arg Phe Glu Ile Pro Ile Lys Val Arg 
            660                 665                 670         


Leu Ser Pro Glu Pro Trp Thr Pro Glu Thr Gly Leu Val Thr Asp Ala 
        675                 680                 685             


Phe Lys Leu Lys Arg Lys Glu Leu Arg Asn His Tyr Leu Lys Asp Ile 
    690                 695                 700                 


Glu Arg Met Tyr Gly Gly Lys 
705                 710     


<210>  86
<211>  711
<212>  PRT
<213>  Homo sapiens

<400>  86

Met Lys Leu Lys Leu Asn Val Leu Thr Ile Ile Leu Leu Pro Val His 
1               5                   10                  15      


Leu Leu Ile Thr Ile Tyr Ser Ala Leu Ile Phe Ile Pro Trp Tyr Phe 
            20                  25                  30          


Leu Thr Asn Ala Lys Lys Lys Asn Ala Met Ala Lys Arg Ile Lys Ala 
        35                  40                  45              


Lys Pro Thr Ser Asp Lys Pro Gly Ser Pro Tyr Arg Ser Val Thr His 
    50                  55                  60                  


Phe Asp Ser Leu Ala Val Ile Asp Ile Pro Gly Ala Asp Thr Leu Asp 
65                  70                  75                  80  


Lys Leu Phe Asp His Ala Val Ser Lys Phe Gly Lys Lys Asp Ser Leu 
                85                  90                  95      


Gly Thr Arg Glu Ile Leu Ser Glu Glu Asn Glu Met Gln Pro Asn Gly 
            100                 105                 110         


Lys Val Phe Lys Lys Leu Ile Leu Gly Asn Tyr Lys Trp Met Asn Tyr 
        115                 120                 125             


Leu Glu Val Asn Arg Arg Val Asn Asn Phe Gly Ser Gly Leu Thr Ala 
    130                 135                 140                 


Leu Gly Leu Lys Pro Lys Asn Thr Ile Ala Ile Phe Cys Glu Thr Arg 
145                 150                 155                 160 


Ala Glu Trp Met Ile Ala Ala Gln Thr Cys Phe Lys Tyr Asn Phe Pro 
                165                 170                 175     


Leu Val Thr Leu Tyr Ala Thr Leu Gly Lys Glu Ala Val Val His Gly 
            180                 185                 190         


Leu Asn Glu Ser Glu Ala Ser Tyr Leu Ile Thr Ser Val Glu Leu Leu 
        195                 200                 205             


Glu Ser Lys Leu Lys Thr Ala Leu Leu Asp Ile Ser Cys Val Lys His 
    210                 215                 220                 


Ile Ile Tyr Val Asp Asn Lys Ala Ile Asn Lys Ala Glu Tyr Pro Glu 
225                 230                 235                 240 


Gly Phe Glu Ile His Ser Met Gln Ser Val Glu Glu Leu Gly Ser Asn 
                245                 250                 255     


Pro Glu Asn Leu Gly Ile Pro Pro Ser Arg Pro Thr Pro Ser Asp Met 
            260                 265                 270         


Ala Ile Val Met Tyr Thr Ser Gly Ser Thr Gly Arg Pro Lys Gly Val 
        275                 280                 285             


Met Met His His Ser Asn Leu Ile Ala Gly Met Thr Gly Gln Cys Glu 
    290                 295                 300                 


Arg Ile Pro Gly Leu Gly Pro Lys Asp Thr Tyr Ile Gly Tyr Leu Pro 
305                 310                 315                 320 


Leu Ala His Val Leu Glu Leu Thr Ala Glu Ile Ser Cys Phe Thr Tyr 
                325                 330                 335     


Gly Cys Arg Ile Gly Tyr Ser Ser Pro Leu Thr Leu Ser Asp Gln Ser 
            340                 345                 350         


Ser Lys Ile Lys Lys Gly Ser Lys Gly Asp Cys Thr Val Leu Lys Pro 
        355                 360                 365             


Thr Leu Met Ala Ala Val Pro Glu Ile Met Asp Arg Ile Tyr Lys Asn 
    370                 375                 380                 


Val Met Ser Lys Val Gln Glu Met Asn Tyr Ile Gln Lys Thr Leu Phe 
385                 390                 395                 400 


Lys Ile Gly Tyr Asp Tyr Lys Leu Glu Gln Ile Lys Lys Gly Tyr Asp 
                405                 410                 415     


Ala Pro Leu Cys Asn Leu Leu Leu Phe Lys Lys Val Lys Ala Leu Leu 
            420                 425                 430         


Gly Gly Asn Val Arg Met Met Leu Ser Gly Gly Ala Pro Leu Ser Pro 
        435                 440                 445             


Gln Thr His Arg Phe Met Asn Val Cys Phe Cys Cys Pro Ile Gly Gln 
    450                 455                 460                 


Gly Tyr Gly Leu Thr Glu Ser Cys Gly Ala Gly Thr Val Thr Glu Val 
465                 470                 475                 480 


Thr Asp Tyr Thr Thr Gly Arg Val Gly Ala Pro Leu Ile Cys Cys Glu 
                485                 490                 495     


Ile Lys Leu Lys Asp Trp Gln Glu Gly Gly Tyr Thr Ile Asn Asp Lys 
            500                 505                 510         


Pro Asn Pro Arg Gly Glu Ile Val Ile Gly Gly Gln Asn Ile Ser Met 
        515                 520                 525             


Gly Tyr Phe Lys Asn Glu Glu Lys Thr Ala Glu Asp Tyr Ser Val Asp 
    530                 535                 540                 


Glu Asn Gly Gln Arg Trp Phe Cys Thr Gly Asp Ile Gly Glu Phe His 
545                 550                 555                 560 


Pro Asp Gly Cys Leu Gln Ile Ile Asp Arg Lys Lys Asp Leu Val Lys 
                565                 570                 575     


Leu Gln Ala Gly Glu Tyr Val Ser Leu Gly Lys Val Glu Ala Ala Leu 
            580                 585                 590         


Lys Asn Cys Pro Leu Ile Asp Asn Ile Cys Ala Phe Ala Lys Ser Asp 
        595                 600                 605             


Gln Ser Tyr Val Ile Ser Phe Val Val Pro Asn Gln Lys Arg Leu Thr 
    610                 615                 620                 


Leu Leu Ala Gln Gln Lys Gly Val Glu Gly Thr Trp Val Asp Ile Cys 
625                 630                 635                 640 


Asn Asn Pro Ala Met Glu Ala Glu Ile Leu Lys Glu Ile Arg Glu Ala 
                645                 650                 655     


Ala Asn Ala Met Lys Leu Glu Arg Phe Glu Ile Pro Ile Lys Val Arg 
            660                 665                 670         


Leu Ser Pro Glu Pro Trp Thr Pro Glu Thr Gly Leu Val Thr Asp Ala 
        675                 680                 685             


Phe Lys Leu Lys Arg Lys Glu Leu Arg Asn His Tyr Leu Lys Asp Ile 
    690                 695                 700                 


Glu Arg Met Tyr Gly Gly Lys 
705                 710     


<210>  87
<211>  54
<212>  PRT
<213>  Homo sapiens

<400>  87

Met Lys Leu Lys Leu Asn Val Leu Thr Ile Ile Leu Leu Pro Val His 
1               5                   10                  15      


Leu Leu Ile Thr Ile Tyr Ser Ala Leu Ile Phe Ile Pro Trp Tyr Phe 
            20                  25                  30          


Leu Thr Asn Ala Lys Lys Lys Asn Ala Met Ala Lys Arg Ile Lys Ala 
        35                  40                  45              


Lys Pro Thr Ser Asp Lys 
    50                  


<210>  88
<211>  145
<212>  PRT
<213>  Homo sapiens

<400>  88

Met Lys Leu Lys Leu Asn Val Leu Thr Ile Ile Leu Leu Pro Val His 
1               5                   10                  15      


Leu Leu Ile Thr Ile Tyr Ser Ala Leu Ile Phe Ile Pro Trp Tyr Phe 
            20                  25                  30          


Leu Thr Asn Ala Lys Lys Lys Asn Ala Met Ala Lys Arg Ile Lys Ala 
        35                  40                  45              


Lys Pro Thr Ser Asp Lys Pro Gly Ser Pro Tyr Arg Ser Val Thr His 
    50                  55                  60                  


Phe Asp Ser Leu Ala Val Ile Asp Ile Pro Gly Ala Asp Thr Leu Asp 
65                  70                  75                  80  


Lys Leu Phe Asp His Ala Val Ser Lys Phe Gly Lys Lys Asp Ser Leu 
                85                  90                  95      


Gly Thr Arg Glu Ile Leu Ser Glu Glu Asn Glu Met Gln Pro Asn Gly 
            100                 105                 110         


Lys Val Phe Lys Lys Leu Ile Leu Gly Asn Tyr Lys Trp Met Asn Tyr 
        115                 120                 125             


Leu Glu Val Asn Arg Arg Val Asn Asn Phe Gly Ser Gly Leu Thr Ala 
    130                 135                 140                 


Leu 
145 


<210>  89
<211>  126
<212>  PRT
<213>  Homo sapiens

<400>  89

Met Lys Leu Lys Leu Asn Val Leu Thr Ile Ile Leu Leu Pro Val His 
1               5                   10                  15      


Leu Leu Ile Thr Ile Tyr Ser Ala Leu Ile Phe Ile Pro Trp Tyr Phe 
            20                  25                  30          


Leu Thr Asn Ala Lys Lys Lys Asn Ala Met Ala Lys Arg Ile Lys Ala 
        35                  40                  45              


Lys Pro Thr Ser Asp Lys Pro Gly Ser Pro Tyr Arg Ser Val Thr His 
    50                  55                  60                  


Phe Asp Ser Leu Ala Val Ile Asp Ile Pro Gly Ala Asp Thr Leu Asp 
65                  70                  75                  80  


Lys Leu Phe Asp His Ala Val Ser Lys Phe Gly Lys Lys Asp Ser Leu 
                85                  90                  95      


Gly Thr Arg Glu Ile Leu Ser Glu Glu Asn Glu Met Gln Pro Asn Gly 
            100                 105                 110         


Lys Val Phe Lys Lys Leu Ile Leu Gly Asn Tyr Lys Trp Met 
        115                 120                 125     


<210>  90
<211>  128
<212>  PRT
<213>  Homo sapiens

<400>  90

Met Lys Leu Lys Leu Asn Val Leu Thr Ile Ile Leu Leu Pro Val His 
1               5                   10                  15      


Leu Leu Ile Thr Ile Tyr Ser Ala Leu Ile Phe Ile Pro Trp Tyr Phe 
            20                  25                  30          


Leu Thr Asn Ala Lys Lys Lys Asn Ala Met Ala Lys Arg Ile Lys Ala 
        35                  40                  45              


Lys Pro Thr Ser Asp Lys Pro Gly Ser Pro Tyr Arg Ser Val Thr His 
    50                  55                  60                  


Phe Asp Ser Leu Ala Val Ile Asp Ile Pro Gly Ala Asp Thr Leu Asp 
65                  70                  75                  80  


Lys Leu Phe Asp His Ala Val Ser Lys Phe Gly Lys Lys Asp Ser Leu 
                85                  90                  95      


Gly Thr Arg Glu Ile Leu Ser Glu Glu Asn Glu Met Gln Pro Asn Gly 
            100                 105                 110         


Lys Val Phe Lys Lys Leu Ile Leu Gly Asn Tyr Lys Trp Met Asn Tyr 
        115                 120                 125             


<210>  91
<211>  80
<212>  PRT
<213>  Homo sapiens

<400>  91

Asn Leu Val Arg Met Arg Ser Gln Ala Leu Gly Gln Ser Ala Pro Ser 
1               5                   10                  15      


Leu Thr Ala Ser Leu Lys Glu Leu Ser Leu Pro Arg Arg Gly Ser Leu 
            20                  25                  30          


Ile Asp Ser Gln Lys Trp Asn Cys Leu Val Lys Arg Ser Leu Ser Pro 
        35                  40                  45              


Thr Pro Ser Ser Pro Gly Ser Pro Cys Ser Pro Leu Leu Ala Phe His 
    50                  55                  60                  


Phe Trp Ser Pro Val Cys Pro Asn Ala Gly Arg Thr Ser Pro Leu Gly 
65                  70                  75                  80  


<210>  92
<211>  58
<212>  PRT
<213>  Homo sapiens

<400>  92

Met Ala Lys Val Ala Lys Asp Leu Asn Pro Gly Val Lys Lys Met Ser 
1               5                   10                  15      


Leu Gly Gln Leu Gln Ser Ala Arg Gly Val Ala Cys Leu Gly Cys Lys 
            20                  25                  30          


Gly Thr Cys Ser Gly Phe Glu Pro His Ser Trp Arg Asp Cys Ser Thr 
        35                  40                  45              


Trp Ser Ser Ser Pro Arg Arg Ser Ser Gln 
    50                  55              


<210>  93
<211>  760
<212>  PRT
<213>  Homo sapiens

<400>  93

Met Met Asp Gln Ala Arg Ser Ala Phe Ser Asn Leu Phe Gly Gly Glu 
1               5                   10                  15      


Pro Leu Ser Tyr Thr Arg Phe Ser Leu Ala Arg Gln Val Asp Gly Asp 
            20                  25                  30          


Asn Ser His Val Glu Met Lys Leu Ala Val Asp Glu Glu Glu Asn Ala 
        35                  40                  45              


Asp Asn Asn Thr Lys Ala Asn Val Thr Lys Pro Lys Arg Cys Ser Gly 
    50                  55                  60                  


Ser Ile Cys Tyr Gly Thr Ile Ala Val Ile Val Phe Phe Leu Ile Gly 
65                  70                  75                  80  


Phe Met Ile Gly Tyr Leu Gly Tyr Cys Lys Gly Val Glu Pro Lys Thr 
                85                  90                  95      


Glu Cys Glu Arg Leu Ala Gly Thr Glu Ser Pro Val Arg Glu Glu Pro 
            100                 105                 110         


Gly Glu Asp Phe Pro Ala Ala Arg Arg Leu Tyr Trp Asp Asp Leu Lys 
        115                 120                 125             


Arg Lys Leu Ser Glu Lys Leu Asp Ser Thr Asp Phe Thr Gly Thr Ile 
    130                 135                 140                 


Lys Leu Leu Asn Glu Asn Ser Tyr Val Pro Arg Glu Ala Gly Ser Gln 
145                 150                 155                 160 


Lys Asp Glu Asn Leu Ala Leu Tyr Val Glu Asn Gln Phe Arg Glu Phe 
                165                 170                 175     


Lys Leu Ser Lys Val Trp Arg Asp Gln His Phe Val Lys Ile Gln Val 
            180                 185                 190         


Lys Asp Ser Ala Gln Asn Ser Val Ile Ile Val Asp Lys Asn Gly Arg 
        195                 200                 205             


Leu Val Tyr Leu Val Glu Asn Pro Gly Gly Tyr Val Ala Tyr Ser Lys 
    210                 215                 220                 


Ala Ala Thr Val Thr Gly Lys Leu Val His Ala Asn Phe Gly Thr Lys 
225                 230                 235                 240 


Lys Asp Phe Glu Asp Leu Tyr Thr Pro Val Asn Gly Ser Ile Val Ile 
                245                 250                 255     


Val Arg Ala Gly Lys Ile Thr Phe Ala Glu Lys Val Ala Asn Ala Glu 
            260                 265                 270         


Ser Leu Asn Ala Ile Gly Val Leu Ile Tyr Met Asp Gln Thr Lys Phe 
        275                 280                 285             


Pro Ile Val Asn Ala Glu Leu Ser Phe Phe Gly His Ala His Leu Gly 
    290                 295                 300                 


Thr Gly Asp Pro Tyr Thr Pro Gly Phe Pro Ser Phe Asn His Thr Gln 
305                 310                 315                 320 


Phe Pro Pro Ser Arg Ser Ser Gly Leu Pro Asn Ile Pro Val Gln Thr 
                325                 330                 335     


Ile Ser Arg Ala Ala Ala Glu Lys Leu Phe Gly Asn Met Glu Gly Asp 
            340                 345                 350         


Cys Pro Ser Asp Trp Lys Thr Asp Ser Thr Cys Arg Met Val Thr Ser 
        355                 360                 365             


Glu Ser Lys Asn Val Lys Leu Thr Val Ser Asn Val Leu Lys Glu Ile 
    370                 375                 380                 


Lys Ile Leu Asn Ile Phe Gly Val Ile Lys Gly Phe Val Glu Pro Asp 
385                 390                 395                 400 


His Tyr Val Val Val Gly Ala Gln Arg Asp Ala Trp Gly Pro Gly Ala 
                405                 410                 415     


Ala Lys Ser Gly Val Gly Thr Ala Leu Leu Leu Lys Leu Ala Gln Met 
            420                 425                 430         


Phe Ser Asp Met Val Leu Lys Asp Gly Phe Gln Pro Ser Arg Ser Ile 
        435                 440                 445             


Ile Phe Ala Ser Trp Ser Ala Gly Asp Phe Gly Ser Val Gly Ala Thr 
    450                 455                 460                 


Glu Trp Leu Glu Gly Tyr Leu Ser Ser Leu His Leu Lys Ala Phe Thr 
465                 470                 475                 480 


Tyr Ile Asn Leu Asp Lys Ala Val Leu Gly Thr Ser Asn Phe Lys Val 
                485                 490                 495     


Ser Ala Ser Pro Leu Leu Tyr Thr Leu Ile Glu Lys Thr Met Gln Asn 
            500                 505                 510         


Val Lys His Pro Val Thr Gly Gln Phe Leu Tyr Gln Asp Ser Asn Trp 
        515                 520                 525             


Ala Ser Lys Val Glu Lys Leu Thr Leu Asp Asn Ala Ala Phe Pro Phe 
    530                 535                 540                 


Leu Ala Tyr Ser Gly Ile Pro Ala Val Ser Phe Cys Phe Cys Glu Asp 
545                 550                 555                 560 


Thr Asp Tyr Pro Tyr Leu Gly Thr Thr Met Asp Thr Tyr Lys Glu Leu 
                565                 570                 575     


Ile Glu Arg Ile Pro Glu Leu Asn Lys Val Ala Arg Ala Ala Ala Glu 
            580                 585                 590         


Val Ala Gly Gln Phe Val Ile Lys Leu Thr His Asp Val Glu Leu Asn 
        595                 600                 605             


Leu Asp Tyr Glu Arg Tyr Asn Ser Gln Leu Leu Ser Phe Val Arg Asp 
    610                 615                 620                 


Leu Asn Gln Tyr Arg Ala Asp Ile Lys Glu Met Gly Leu Ser Leu Gln 
625                 630                 635                 640 


Trp Leu Tyr Ser Ala Arg Gly Asp Phe Phe Arg Ala Thr Ser Arg Leu 
                645                 650                 655     


Thr Thr Asp Phe Gly Asn Ala Glu Lys Thr Asp Arg Phe Val Met Lys 
            660                 665                 670         


Lys Leu Asn Asp Arg Val Met Arg Val Glu Tyr His Phe Leu Ser Pro 
        675                 680                 685             


Tyr Val Ser Pro Lys Glu Ser Pro Phe Arg His Val Phe Trp Gly Ser 
    690                 695                 700                 


Gly Ser His Thr Leu Pro Ala Leu Leu Glu Asn Leu Lys Leu Arg Lys 
705                 710                 715                 720 


Gln Asn Asn Gly Ala Phe Asn Glu Thr Leu Phe Arg Asn Gln Leu Ala 
                725                 730                 735     


Leu Ala Thr Trp Thr Ile Gln Gly Ala Ala Asn Ala Leu Ser Gly Asp 
            740                 745                 750         


Val Trp Asp Ile Asp Asn Glu Phe 
        755                 760 


<210>  94
<211>  760
<212>  PRT
<213>  Homo sapiens

<400>  94

Met Met Asp Gln Ala Arg Ser Ala Phe Ser Asn Leu Phe Gly Gly Glu 
1               5                   10                  15      


Pro Leu Ser Tyr Thr Arg Phe Ser Leu Ala Arg Gln Val Asp Gly Asp 
            20                  25                  30          


Asn Ser His Val Glu Met Lys Leu Ala Val Asp Glu Glu Glu Asn Ala 
        35                  40                  45              


Asp Asn Asn Thr Lys Ala Asn Val Thr Lys Pro Lys Arg Cys Ser Gly 
    50                  55                  60                  


Ser Ile Cys Tyr Gly Thr Ile Ala Val Ile Val Phe Phe Leu Ile Gly 
65                  70                  75                  80  


Phe Met Ile Gly Tyr Leu Gly Tyr Cys Lys Gly Val Glu Pro Lys Thr 
                85                  90                  95      


Glu Cys Glu Arg Leu Ala Gly Thr Glu Ser Pro Val Arg Glu Glu Pro 
            100                 105                 110         


Gly Glu Asp Phe Pro Ala Ala Arg Arg Leu Tyr Trp Asp Asp Leu Lys 
        115                 120                 125             


Arg Lys Leu Ser Glu Lys Leu Asp Ser Thr Asp Phe Thr Gly Thr Ile 
    130                 135                 140                 


Lys Leu Leu Asn Glu Asn Ser Tyr Val Pro Arg Glu Ala Gly Ser Gln 
145                 150                 155                 160 


Lys Asp Glu Asn Leu Ala Leu Tyr Val Glu Asn Gln Phe Arg Glu Phe 
                165                 170                 175     


Lys Leu Ser Lys Val Trp Arg Asp Gln His Phe Val Lys Ile Gln Val 
            180                 185                 190         


Lys Asp Ser Ala Gln Asn Ser Val Ile Ile Val Asp Lys Asn Gly Arg 
        195                 200                 205             


Leu Val Tyr Leu Val Glu Asn Pro Gly Gly Tyr Val Ala Tyr Ser Lys 
    210                 215                 220                 


Ala Ala Thr Val Thr Gly Lys Leu Val His Ala Asn Phe Gly Thr Lys 
225                 230                 235                 240 


Lys Asp Phe Glu Asp Leu Tyr Thr Pro Val Asn Gly Ser Ile Val Ile 
                245                 250                 255     


Val Arg Ala Gly Lys Ile Thr Phe Ala Glu Lys Val Ala Asn Ala Glu 
            260                 265                 270         


Ser Leu Asn Ala Ile Gly Val Leu Ile Tyr Met Asp Gln Thr Lys Phe 
        275                 280                 285             


Pro Ile Val Asn Ala Glu Leu Ser Phe Phe Gly His Ala His Leu Gly 
    290                 295                 300                 


Thr Gly Asp Pro Tyr Thr Pro Gly Phe Pro Ser Phe Asn His Thr Gln 
305                 310                 315                 320 


Phe Pro Pro Ser Arg Ser Ser Gly Leu Pro Asn Ile Pro Val Gln Thr 
                325                 330                 335     


Ile Ser Arg Ala Ala Ala Glu Lys Leu Phe Gly Asn Met Glu Gly Asp 
            340                 345                 350         


Cys Pro Ser Asp Trp Lys Thr Asp Ser Thr Cys Arg Met Val Thr Ser 
        355                 360                 365             


Glu Ser Lys Asn Val Lys Leu Thr Val Ser Asn Val Leu Lys Glu Ile 
    370                 375                 380                 


Lys Ile Leu Asn Ile Phe Gly Val Ile Lys Gly Phe Val Glu Pro Asp 
385                 390                 395                 400 


His Tyr Val Val Val Gly Ala Gln Arg Asp Ala Trp Gly Pro Gly Ala 
                405                 410                 415     


Ala Lys Ser Gly Val Gly Thr Ala Leu Leu Leu Lys Leu Ala Gln Met 
            420                 425                 430         


Phe Ser Asp Met Val Leu Lys Asp Gly Phe Gln Pro Ser Arg Ser Ile 
        435                 440                 445             


Ile Phe Ala Ser Trp Ser Ala Gly Asp Phe Gly Ser Val Gly Ala Thr 
    450                 455                 460                 


Glu Trp Leu Glu Gly Tyr Leu Ser Ser Leu His Leu Lys Ala Phe Thr 
465                 470                 475                 480 


Tyr Ile Asn Leu Asp Lys Ala Val Leu Gly Thr Ser Asn Phe Lys Val 
                485                 490                 495     


Ser Ala Ser Pro Leu Leu Tyr Thr Leu Ile Glu Lys Thr Met Gln Asn 
            500                 505                 510         


Val Lys His Pro Val Thr Gly Gln Phe Leu Tyr Gln Asp Ser Asn Trp 
        515                 520                 525             


Ala Ser Lys Val Glu Lys Leu Thr Leu Asp Asn Ala Ala Phe Pro Phe 
    530                 535                 540                 


Leu Ala Tyr Ser Gly Ile Pro Ala Val Ser Phe Cys Phe Cys Glu Asp 
545                 550                 555                 560 


Thr Asp Tyr Pro Tyr Leu Gly Thr Thr Met Asp Thr Tyr Lys Glu Leu 
                565                 570                 575     


Ile Glu Arg Ile Pro Glu Leu Asn Lys Val Ala Arg Ala Ala Ala Glu 
            580                 585                 590         


Val Ala Gly Gln Phe Val Ile Lys Leu Thr His Asp Val Glu Leu Asn 
        595                 600                 605             


Leu Asp Tyr Glu Arg Tyr Asn Ser Gln Leu Leu Ser Phe Val Arg Asp 
    610                 615                 620                 


Leu Asn Gln Tyr Arg Ala Asp Ile Lys Glu Met Gly Leu Ser Leu Gln 
625                 630                 635                 640 


Trp Leu Tyr Ser Ala Arg Gly Asp Phe Phe Arg Ala Thr Ser Arg Leu 
                645                 650                 655     


Thr Thr Asp Phe Gly Asn Ala Glu Lys Thr Asp Arg Phe Val Met Lys 
            660                 665                 670         


Lys Leu Asn Asp Arg Val Met Arg Val Glu Tyr His Phe Leu Ser Pro 
        675                 680                 685             


Tyr Val Ser Pro Lys Glu Ser Pro Phe Arg His Val Phe Trp Gly Ser 
    690                 695                 700                 


Gly Ser His Thr Leu Pro Ala Leu Leu Glu Asn Leu Lys Leu Arg Lys 
705                 710                 715                 720 


Gln Asn Asn Gly Ala Phe Asn Glu Thr Leu Phe Arg Asn Gln Leu Ala 
                725                 730                 735     


Leu Ala Thr Trp Thr Ile Gln Gly Ala Ala Asn Ala Leu Ser Gly Asp 
            740                 745                 750         


Val Trp Asp Ile Asp Asn Glu Phe 
        755                 760 


<210>  95
<211>  81
<212>  PRT
<213>  Homo sapiens

<400>  95

Met Met Asp Gln Ala Arg Ser Ala Phe Ser Asn Leu Phe Gly Gly Glu 
1               5                   10                  15      


Pro Leu Ser Tyr Thr Arg Phe Ser Leu Ala Arg Gln Val Asp Gly Asp 
            20                  25                  30          


Asn Ser His Val Glu Met Lys Leu Ala Val Asp Glu Glu Glu Asn Ala 
        35                  40                  45              


Asp Asn Asn Thr Lys Ala Asn Val Thr Lys Pro Lys Arg Cys Ser Gly 
    50                  55                  60                  


Ser Ile Cys Tyr Gly Thr Ile Ala Val Ile Val Phe Phe Leu Ile Gly 
65                  70                  75                  80  


Cys 
    


<210>  96
<211>  118
<212>  PRT
<213>  Homo sapiens

<400>  96

Ala Ala Ala Glu Val Ala Gly Gln Phe Val Ile Lys Leu Thr His Asp 
1               5                   10                  15      


Val Glu Leu Asn Leu Asp Tyr Glu Arg Tyr Asn Ser Gln Leu Leu Ser 
            20                  25                  30          


Phe Val Arg Asp Leu Asn Gln Tyr Arg Ala Asp Ile Lys Glu Met Gly 
        35                  40                  45              


Leu Ser Leu Gln Trp Leu Tyr Ser Ala Arg Gly Asp Phe Phe Arg Ala 
    50                  55                  60                  


Thr Ser Arg Leu Thr Thr Asp Phe Gly Asn Ala Glu Lys Thr Asp Arg 
65                  70                  75                  80  


Phe Val Met Lys Lys Leu Asn Asp Arg Val Met Arg Glu Gly Pro Gln 
                85                  90                  95      


Met Met Leu Leu Leu Thr Asp Ala Arg Pro Ser Asn His Phe Leu Ser 
            100                 105                 110         


Pro Leu Leu Ser Leu His 
        115             


<210>  97
<211>  643
<212>  PRT
<213>  Homo sapiens

<400>  97

Met His His Leu Leu Glu Gln Ser Ala Asp Met Ala Thr Ala Leu Leu 
1               5                   10                  15      


Ala Gly Glu Lys Leu Arg Glu Leu Ile Leu Pro Gly Ala Gln Asp Asp 
            20                  25                  30          


Lys Ala Gly Ala Leu Ala Ala Leu Leu Leu Gln Leu Lys Leu Glu Leu 
        35                  40                  45              


Pro Phe Asp Arg Val Val Thr Ile Gly Thr Val Leu Val Pro Ile Leu 
    50                  55                  60                  


Leu Val Thr Leu Val Phe Thr Lys Asn Phe Ala Glu Glu Pro Ile Tyr 
65                  70                  75                  80  


Cys Tyr Thr Pro His Asn Phe Thr Arg Asp Gln Ala Leu Tyr Ala Arg 
                85                  90                  95      


Gly Tyr Cys Trp Thr Glu Leu Arg Asp Ala Leu Pro Gly Val Asp Ala 
            100                 105                 110         


Ser Leu Trp Pro Ser Leu Phe Glu His Lys Phe Leu Pro Tyr Ala Leu 
        115                 120                 125             


Leu Ala Phe Ala Ala Ile Met Tyr Val Pro Ala Leu Gly Trp Glu Phe 
    130                 135                 140                 


Leu Ala Ser Thr Arg Leu Thr Ser Glu Leu Asn Phe Leu Leu Gln Glu 
145                 150                 155                 160 


Ile Asp Asn Cys Tyr His Arg Ala Ala Glu Gly Arg Ala Pro Lys Ile 
                165                 170                 175     


Glu Lys Gln Ile Gln Ser Lys Gly Pro Gly Ile Thr Glu Arg Glu Lys 
            180                 185                 190         


Arg Glu Ile Ile Glu Asn Ala Glu Lys Glu Lys Ser Pro Glu Gln Asn 
        195                 200                 205             


Leu Phe Glu Lys Tyr Leu Glu Arg Arg Gly Arg Ser Asn Phe Leu Ala 
    210                 215                 220                 


Lys Leu Tyr Leu Ala Arg His Val Leu Ile Leu Leu Leu Ser Ala Val 
225                 230                 235                 240 


Pro Ile Ser Tyr Leu Cys Thr Tyr Tyr Ala Thr Gln Lys Gln Asn Glu 
                245                 250                 255     


Phe Thr Cys Ala Leu Gly Ala Ser Pro Asp Gly Ala Ala Gly Ala Gly 
            260                 265                 270         


Pro Ala Val Arg Val Ser Cys Lys Leu Pro Ser Val Gln Leu Gln Arg 
        275                 280                 285             


Ile Ile Ala Gly Val Asp Ile Val Leu Leu Cys Val Met Asn Leu Ile 
    290                 295                 300                 


Ile Leu Val Asn Leu Ile His Leu Phe Ile Phe Arg Lys Ser Asn Phe 
305                 310                 315                 320 


Ile Phe Asp Lys Leu His Lys Val Gly Ile Lys Thr Arg Arg Gln Trp 
                325                 330                 335     


Arg Arg Ser Gln Phe Cys Asp Ile Asn Ile Leu Ala Met Phe Cys Asn 
            340                 345                 350         


Glu Asn Arg Asp His Ile Lys Ser Leu Asn Arg Leu Asp Phe Ile Thr 
        355                 360                 365             


Asn Glu Ser Asp Leu Met Tyr Asp Asn Val Val Arg Gln Leu Leu Ala 
    370                 375                 380                 


Ala Leu Ala Gln Ser Asn His Asp Ala Thr Pro Thr Val Arg Asp Ser 
385                 390                 395                 400 


Gly Val Gln Thr Val Asp Pro Ser Ala Asn Pro Ala Glu Pro Asp Gly 
                405                 410                 415     


Ala Ala Glu Pro Pro Val Val Lys Arg Pro Arg Lys Lys Met Lys Trp 
            420                 425                 430         


Ile Pro Thr Ser Asn Pro Leu Pro Gln Pro Phe Lys Glu Pro Leu Ala 
        435                 440                 445             


Ile Met Arg Val Glu Asn Ser Lys Ala Glu Lys Pro Lys Pro Ala Arg 
    450                 455                 460                 


Arg Lys Thr Ala Thr Asp Thr Leu Ile Ala Pro Leu Leu Asp Arg Ser 
465                 470                 475                 480 


Ala His His Tyr Lys Gly Gly Gly Gly Asp Pro Gly Pro Gly Pro Ala 
                485                 490                 495     


Pro Ala Pro Ala Pro Pro Pro Ala Pro Asp Lys Lys His Ala Arg His 
            500                 505                 510         


Phe Ser Leu Asp Val His Pro Tyr Ile Leu Gly Thr Lys Lys Ala Lys 
        515                 520                 525             


Ala Glu Ala Val Pro Ala Ala Leu Pro Ala Ser Arg Ser Gln Glu Gly 
    530                 535                 540                 


Gly Phe Leu Ser Gln Ala Glu Asp Cys Gly Leu Gly Leu Ala Pro Ala 
545                 550                 555                 560 


Pro Ile Lys Asp Ala Pro Leu Pro Glu Lys Glu Ile Pro Tyr Pro Thr 
                565                 570                 575     


Glu Pro Ala Arg Ala Gly Leu Pro Ser Gly Gly Pro Phe His Val Arg 
            580                 585                 590         


Ser Pro Pro Ala Ala Pro Ala Val Ala Pro Leu Thr Pro Ala Ser Leu 
        595                 600                 605             


Gly Lys Ala Glu Pro Leu Thr Ile Leu Ser Arg Asn Ala Thr His Pro 
    610                 615                 620                 


Leu Leu His Ile Asn Thr Leu Ser Ser Ser Pro Pro Ser Thr Ser Arg 
625                 630                 635                 640 


Glu Arg Ser 
            


<210>  98
<211>  677
<212>  PRT
<213>  Homo sapiens

<400>  98

Met His His Leu Leu Glu Gln Ser Ala Asp Met Ala Thr Ala Leu Leu 
1               5                   10                  15      


Ala Gly Glu Lys Leu Arg Glu Leu Ile Leu Pro Gly Ala Gln Asp Asp 
            20                  25                  30          


Lys Ala Gly Ala Leu Ala Ala Leu Leu Leu Gln Leu Lys Leu Glu Leu 
        35                  40                  45              


Pro Phe Asp Arg Val Val Thr Ile Gly Thr Val Leu Val Pro Ile Leu 
    50                  55                  60                  


Leu Val Thr Leu Val Phe Thr Lys Asn Phe Ala Glu Glu Pro Ile Tyr 
65                  70                  75                  80  


Cys Tyr Thr Pro His Asn Phe Thr Arg Asp Gln Ala Leu Tyr Ala Arg 
                85                  90                  95      


Gly Tyr Cys Trp Thr Glu Leu Arg Asp Ala Leu Pro Gly Val Asp Ala 
            100                 105                 110         


Ser Leu Trp Pro Ser Leu Phe Glu His Lys Phe Leu Pro Tyr Ala Leu 
        115                 120                 125             


Leu Ala Phe Ala Ala Ile Met Tyr Val Pro Ala Leu Gly Trp Glu Phe 
    130                 135                 140                 


Leu Ala Ser Thr Arg Leu Thr Ser Glu Leu Asn Phe Leu Leu Gln Glu 
145                 150                 155                 160 


Ile Asp Asn Cys Tyr His Arg Ala Ala Glu Gly Arg Ala Pro Lys Ile 
                165                 170                 175     


Glu Lys Gln Ile Gln Ser Lys Gly Pro Gly Ile Thr Glu Arg Glu Lys 
            180                 185                 190         


Arg Glu Ile Ile Glu Asn Ala Glu Lys Glu Lys Ser Pro Glu Gln Asn 
        195                 200                 205             


Leu Phe Glu Lys Tyr Leu Glu Arg Arg Gly Arg Ser Asn Phe Leu Ala 
    210                 215                 220                 


Lys Leu Tyr Leu Ala Arg His Val Leu Ile Leu Leu Leu Ser Ala Val 
225                 230                 235                 240 


Pro Ile Ser Tyr Leu Cys Thr Tyr Tyr Ala Thr Gln Lys Gln Asn Glu 
                245                 250                 255     


Phe Thr Cys Ala Leu Gly Ala Ser Pro Asp Gly Ala Ala Gly Ala Gly 
            260                 265                 270         


Pro Ala Val Arg Val Ser Cys Lys Leu Pro Ser Val Gln Leu Gln Arg 
        275                 280                 285             


Ile Ile Ala Gly Val Asp Ile Val Leu Leu Cys Val Met Asn Leu Ile 
    290                 295                 300                 


Ile Leu Val Asn Leu Ile His Leu Phe Ile Phe Arg Lys Ser Asn Phe 
305                 310                 315                 320 


Ile Phe Asp Lys Leu His Lys Val Gly Ile Lys Thr Arg Arg Gln Trp 
                325                 330                 335     


Arg Arg Ser Gln Phe Cys Asp Ile Asn Ile Leu Ala Met Phe Cys Asn 
            340                 345                 350         


Glu Asn Arg Asp His Ile Lys Ser Leu Asn Arg Leu Asp Phe Ile Thr 
        355                 360                 365             


Asn Glu Ser Asp Leu Met Tyr Asp Asn Val Val Arg Gln Leu Leu Ala 
    370                 375                 380                 


Ala Leu Ala Gln Ser Asn His Asp Ala Thr Pro Thr Val Arg Asp Ser 
385                 390                 395                 400 


Gly Val Gln Thr Val Asp Pro Ser Ala Asn Pro Ala Glu Pro Asp Gly 
                405                 410                 415     


Ala Ala Glu Pro Pro Val Val Lys Arg Pro Arg Lys Lys Met Lys Trp 
            420                 425                 430         


Ile Pro Thr Ser Asn Pro Leu Pro Gln Pro Phe Lys Glu Pro Leu Ala 
        435                 440                 445             


Ile Met Arg Val Glu Asn Ser Lys Ala Glu Lys Pro Lys Pro Ala Arg 
    450                 455                 460                 


Arg Lys Thr Ala Thr Asp Thr Leu Ile Ala Pro Leu Leu Asp Arg Ser 
465                 470                 475                 480 


Ala His His Tyr Lys Gly Gly Gly Gly Asp Pro Gly Pro Gly Pro Ala 
                485                 490                 495     


Pro Ala Pro Ala Pro Pro Pro Ala Pro Asp Lys Lys His Ala Arg His 
            500                 505                 510         


Phe Ser Leu Asp Val His Pro Tyr Ile Leu Gly Thr Lys Lys Ala Lys 
        515                 520                 525             


Ala Glu Ala Val Pro Ala Ala Leu Pro Ala Ser Arg Ser Gln Glu Gly 
    530                 535                 540                 


Gly Phe Leu Ser Gln Ala Glu Asp Cys Gly Leu Gly Leu Ala Pro Ala 
545                 550                 555                 560 


Pro Ile Lys Asp Ala Pro Leu Pro Glu Lys Glu Ile Pro Tyr Pro Thr 
                565                 570                 575     


Glu Pro Ala Arg Ala Gly Leu Pro Ser Gly Gly Pro Phe His Val Arg 
            580                 585                 590         


Ser Pro Pro Ala Ala Pro Ala Val Ala Pro Leu Thr Pro Ala Ser Leu 
        595                 600                 605             


Gly Lys Ala Glu Pro Leu Thr Ile Leu Ser Arg Asn Ala Thr His Pro 
    610                 615                 620                 


Leu Leu His Ile Asn Thr Leu Tyr Glu Ala Arg Glu Glu Glu Asp Gly 
625                 630                 635                 640 


Gly Pro Arg Leu Pro Gln Asp Val Gly Asp Leu Ile Ala Ile Pro Ala 
                645                 650                 655     


Pro Gln Gln Ile Leu Ile Ala Thr Phe Asp Glu Pro Arg Thr Val Val 
            660                 665                 670         


Ser Thr Val Glu Phe 
        675         


<210>  99
<211>  77
<212>  PRT
<213>  Homo sapiens

<400>  99

Met Ala Thr Ala Leu Leu Ala Gly Glu Lys Leu Arg Glu Leu Ile Leu 
1               5                   10                  15      


Pro Gly Ala Gln Asp Asp Lys Ala Gly Ala Leu Ala Ala Leu Leu Leu 
            20                  25                  30          


Gln Leu Lys Leu Glu Leu Pro Phe Asp Arg Val Val Thr Ile Gly Thr 
        35                  40                  45              


Val Leu Val Pro Ile Leu Leu Val Thr Leu Val Phe Thr Lys Asn Phe 
    50                  55                  60                  


Ala Gly Trp Thr Leu Phe Ser Gly Ser Trp Asp Trp Leu 
65                  70                  75          


<210>  100
<211>  1204
<212>  PRT
<213>  Homo sapiens

<400>  100

Met Tyr Val Thr Met Met Met Thr Asp Gln Ile Pro Leu Glu Leu Pro 
1               5                   10                  15      


Pro Leu Leu Asn Gly Glu Val Ala Met Met Pro His Leu Val Asn Gly 
            20                  25                  30          


Asp Ala Ala Gln Gln Val Ile Leu Val Gln Val Asn Pro Gly Glu Thr 
        35                  40                  45              


Phe Thr Ile Arg Ala Glu Asp Gly Thr Leu Gln Cys Ile Gln Gly Pro 
    50                  55                  60                  


Ala Glu Val Pro Met Met Ser Pro Asn Gly Ser Ile Pro Pro Ile His 
65                  70                  75                  80  


Val Pro Pro Gly Tyr Ile Ser Gln Val Ile Glu Asp Ser Thr Gly Val 
                85                  90                  95      


Arg Arg Val Val Val Thr Pro Gln Ser Pro Glu Cys Tyr Pro Pro Ser 
            100                 105                 110         


Tyr Pro Ser Ala Met Ser Pro Thr His His Leu Pro Pro Tyr Leu Thr 
        115                 120                 125             


His His Pro His Phe Ile His Asn Ser His Thr Ala Tyr Tyr Pro Pro 
    130                 135                 140                 


Val Thr Gly Pro Gly Asp Met Pro Pro Gln Phe Phe Pro Gln His His 
145                 150                 155                 160 


Leu Pro His Thr Ile Tyr Gly Glu Gln Glu Ile Ile Pro Phe Tyr Gly 
                165                 170                 175     


Met Ser Thr Tyr Ile Thr Arg Glu Asp Gln Tyr Ser Lys Pro Pro His 
            180                 185                 190         


Lys Lys Leu Lys Asp Arg Gln Ile Asp Arg Gln Asn Arg Leu Asn Ser 
        195                 200                 205             


Pro Pro Ser Ser Ile Tyr Lys Ser Ser Cys Thr Thr Val Tyr Asn Gly 
    210                 215                 220                 


Tyr Gly Lys Gly His Ser Gly Gly Ser Gly Gly Gly Gly Ser Gly Ser 
225                 230                 235                 240 


Gly Pro Gly Ile Lys Lys Thr Glu Arg Arg Ala Arg Ser Ser Pro Lys 
                245                 250                 255     


Ser Asn Asp Ser Asp Leu Gln Glu Tyr Glu Leu Glu Val Lys Arg Val 
            260                 265                 270         


Gln Asp Ile Leu Ser Gly Ile Glu Lys Pro Gln Val Ser Asn Ile Gln 
        275                 280                 285             


Ala Arg Ala Val Val Leu Ser Trp Ala Pro Pro Val Gly Leu Ser Cys 
    290                 295                 300                 


Gly Pro His Ser Gly Leu Ser Phe Pro Tyr Ser Tyr Glu Val Ala Leu 
305                 310                 315                 320 


Ser Asp Lys Gly Arg Asp Gly Lys Tyr Lys Ile Ile Tyr Ser Gly Glu 
                325                 330                 335     


Glu Leu Glu Cys Asn Leu Lys Asp Leu Arg Pro Ala Thr Asp Tyr His 
            340                 345                 350         


Val Arg Val Tyr Ala Met Tyr Asn Ser Val Lys Gly Ser Cys Ser Glu 
        355                 360                 365             


Pro Val Ser Phe Thr Thr His Ser Cys Ala Pro Glu Cys Pro Phe Pro 
    370                 375                 380                 


Pro Lys Leu Ala His Arg Ser Lys Ser Ser Leu Thr Leu Gln Trp Lys 
385                 390                 395                 400 


Ala Pro Ile Asp Asn Gly Ser Lys Ile Thr Asn Tyr Leu Leu Glu Trp 
                405                 410                 415     


Asp Glu Gly Lys Arg Asn Ser Gly Phe Arg Gln Cys Phe Phe Gly Ser 
            420                 425                 430         


Gln Lys His Cys Lys Leu Thr Lys Leu Cys Pro Ala Met Gly Tyr Thr 
        435                 440                 445             


Phe Arg Leu Ala Ala Arg Asn Asp Ile Gly Thr Ser Gly Tyr Ser Gln 
    450                 455                 460                 


Glu Val Val Cys Tyr Thr Leu Gly Asn Ile Pro Gln Met Pro Ser Ala 
465                 470                 475                 480 


Pro Arg Leu Val Arg Ala Gly Ile Thr Trp Val Thr Leu Gln Trp Ser 
                485                 490                 495     


Lys Pro Glu Gly Cys Ser Pro Glu Glu Val Ile Thr Tyr Thr Leu Glu 
            500                 505                 510         


Ile Gln Glu Asp Glu Asn Asp Asn Leu Phe His Pro Lys Tyr Thr Gly 
        515                 520                 525             


Glu Asp Leu Thr Cys Thr Val Lys Asn Leu Lys Arg Ser Thr Gln Tyr 
    530                 535                 540                 


Lys Phe Arg Leu Thr Ala Ser Asn Thr Glu Gly Lys Ser Cys Pro Ser 
545                 550                 555                 560 


Glu Val Leu Val Cys Thr Thr Ser Pro Asp Arg Pro Gly Pro Pro Thr 
                565                 570                 575     


Arg Pro Leu Val Lys Gly Pro Val Thr Ser His Gly Phe Ser Val Lys 
            580                 585                 590         


Trp Asp Pro Pro Lys Asp Asn Gly Gly Ser Glu Ile Leu Lys Tyr Leu 
        595                 600                 605             


Leu Glu Ile Thr Asp Gly Asn Ser Glu Ala Asn Gln Trp Glu Val Ala 
    610                 615                 620                 


Tyr Ser Gly Ser Ala Thr Glu Tyr Thr Phe Thr His Leu Lys Pro Gly 
625                 630                 635                 640 


Thr Leu Tyr Lys Leu Arg Ala Cys Cys Ile Ser Thr Gly Gly His Ser 
                645                 650                 655     


Gln Cys Ser Glu Ser Leu Pro Val Arg Thr Leu Ser Ile Ala Pro Gly 
            660                 665                 670         


Gln Cys Arg Pro Pro Arg Val Leu Gly Arg Pro Lys His Lys Glu Val 
        675                 680                 685             


His Leu Glu Trp Asp Val Pro Ala Ser Glu Ser Gly Cys Glu Val Ser 
    690                 695                 700                 


Glu Tyr Ser Val Glu Met Thr Glu Pro Glu Asp Val Ala Ser Glu Val 
705                 710                 715                 720 


Tyr His Gly Pro Glu Leu Glu Cys Thr Val Gly Asn Leu Leu Pro Gly 
                725                 730                 735     


Thr Val Tyr Arg Phe Arg Val Arg Ala Leu Asn Asp Gly Gly Tyr Gly 
            740                 745                 750         


Pro Tyr Ser Asp Val Ser Glu Ile Thr Thr Ala Ala Gly Pro Pro Gly 
        755                 760                 765             


Gln Cys Lys Ala Pro Cys Ile Ser Cys Thr Pro Asp Gly Cys Val Leu 
    770                 775                 780                 


Val Gly Trp Glu Ser Pro Asp Ser Ser Gly Ala Asp Ile Ser Glu Tyr 
785                 790                 795                 800 


Arg Leu Glu Trp Gly Glu Asp Glu Glu Ser Leu Glu Leu Ile Tyr His 
                805                 810                 815     


Gly Thr Asp Thr Arg Phe Glu Ile Arg Asp Leu Leu Pro Ala Ala Gln 
            820                 825                 830         


Tyr Cys Cys Arg Leu Gln Ala Phe Asn Gln Ala Gly Ala Gly Pro Tyr 
        835                 840                 845             


Ser Glu Leu Val Leu Cys Gln Thr Pro Ala Ser Ala Pro Asp Pro Val 
    850                 855                 860                 


Ser Thr Leu Cys Val Leu Glu Glu Glu Pro Leu Asp Ala Tyr Pro Asp 
865                 870                 875                 880 


Ser Pro Ser Ala Cys Leu Val Leu Asn Trp Glu Glu Pro Cys Asn Asn 
                885                 890                 895     


Gly Ser Glu Ile Leu Ala Tyr Thr Ile Asp Leu Gly Asp Thr Ser Ile 
            900                 905                 910         


Thr Val Gly Asn Thr Thr Met His Val Met Lys Asp Leu Leu Pro Glu 
        915                 920                 925             


Thr Thr Tyr Arg Ile Arg Ile Gln Ala Ile Asn Glu Ile Gly Ala Gly 
    930                 935                 940                 


Pro Phe Ser Gln Phe Ile Lys Ala Lys Thr Arg Pro Leu Pro Pro Leu 
945                 950                 955                 960 


Pro Pro Arg Leu Glu Cys Ala Ala Ala Gly Pro Gln Ser Leu Lys Leu 
                965                 970                 975     


Lys Trp Gly Asp Ser Asn Ser Lys Thr His Ala Ala Glu Asp Ile Val 
            980                 985                 990         


Tyr Thr Leu Gln Leu Glu Asp Arg  Asn Lys Arg Phe Ile  Ser Ile Tyr 
        995                 1000                 1005             


Arg Gly  Pro Ser His Thr Tyr  Lys Val Gln Arg Leu  Thr Glu Phe 
    1010                 1015                 1020             


Thr Cys  Tyr Ser Phe Arg Ile  Gln Ala Ala Ser Glu  Ala Gly Glu 
    1025                 1030                 1035             


Gly Pro  Phe Ser Glu Thr Tyr  Thr Phe Ser Thr Thr  Lys Ser Val 
    1040                 1045                 1050             


Pro Pro  Thr Ile Lys Ala Pro  Arg Val Thr Gln Leu  Glu Gly Asn 
    1055                 1060                 1065             


Ser Cys  Glu Ile Leu Trp Glu  Thr Val Pro Ser Met  Lys Gly Asp 
    1070                 1075                 1080             


Pro Val  Asn Tyr Ile Leu Gln  Val Leu Val Gly Arg  Glu Ser Glu 
    1085                 1090                 1095             


Tyr Lys  Gln Val Tyr Lys Gly  Glu Glu Ala Thr Phe  Gln Ile Ser 
    1100                 1105                 1110             


Gly Leu  Gln Thr Asn Thr Asp  Tyr Arg Phe Arg Val  Cys Ala Cys 
    1115                 1120                 1125             


Arg Arg  Cys Leu Asp Thr Ser  Gln Glu Leu Ser Gly  Ala Phe Ser 
    1130                 1135                 1140             


Pro Ser  Ala Ala Phe Val Leu  Gln Arg Ser Glu Val  Met Leu Thr 
    1145                 1150                 1155             


Gly Asp  Met Gly Ser Leu Asp  Asp Pro Lys Met Lys  Ser Met Met 
    1160                 1165                 1170             


Pro Thr  Asp Glu Gln Phe Ala  Ala Ile Ile Val Leu  Gly Phe Ala 
    1175                 1180                 1185             


Thr Leu  Ser Ile Leu Phe Ala  Phe Ile Leu Gln Tyr  Phe Leu Met 
    1190                 1195                 1200             


Lys 
    


<210>  101
<211>  1204
<212>  PRT
<213>  Homo sapiens

<400>  101

Met Tyr Val Thr Met Met Met Thr Asp Gln Ile Pro Leu Glu Leu Pro 
1               5                   10                  15      


Pro Leu Leu Asn Gly Glu Val Ala Met Met Pro His Leu Val Asn Gly 
            20                  25                  30          


Asp Ala Ala Gln Gln Val Ile Leu Val Gln Val Asn Pro Gly Glu Thr 
        35                  40                  45              


Phe Thr Ile Arg Ala Glu Asp Gly Thr Leu Gln Cys Ile Gln Gly Pro 
    50                  55                  60                  


Ala Glu Val Pro Met Met Ser Pro Asn Gly Ser Ile Pro Pro Ile His 
65                  70                  75                  80  


Val Pro Pro Gly Tyr Ile Ser Gln Val Ile Glu Asp Ser Thr Gly Val 
                85                  90                  95      


Arg Arg Val Val Val Thr Pro Gln Ser Pro Glu Cys Tyr Pro Pro Ser 
            100                 105                 110         


Tyr Pro Ser Ala Met Ser Pro Thr His His Leu Pro Pro Tyr Leu Thr 
        115                 120                 125             


His His Pro His Phe Ile His Asn Ser His Thr Ala Tyr Tyr Pro Pro 
    130                 135                 140                 


Val Thr Gly Pro Gly Asp Met Pro Pro Gln Phe Phe Pro Gln His His 
145                 150                 155                 160 


Leu Pro His Thr Ile Tyr Gly Glu Gln Glu Ile Ile Pro Phe Tyr Gly 
                165                 170                 175     


Met Ser Thr Tyr Ile Thr Arg Glu Asp Gln Tyr Ser Lys Pro Pro His 
            180                 185                 190         


Lys Lys Leu Lys Asp Arg Gln Ile Asp Arg Gln Asn Arg Leu Asn Ser 
        195                 200                 205             


Pro Pro Ser Ser Ile Tyr Lys Ser Ser Cys Thr Thr Val Tyr Asn Gly 
    210                 215                 220                 


Tyr Gly Lys Gly His Ser Gly Gly Ser Gly Gly Gly Gly Ser Gly Ser 
225                 230                 235                 240 


Gly Pro Gly Ile Lys Lys Thr Glu Arg Arg Ala Arg Ser Ser Pro Lys 
                245                 250                 255     


Ser Asn Asp Ser Asp Leu Gln Glu Tyr Glu Leu Glu Val Lys Arg Val 
            260                 265                 270         


Gln Asp Ile Leu Ser Gly Ile Glu Lys Pro Gln Val Ser Asn Ile Gln 
        275                 280                 285             


Ala Arg Ala Val Val Leu Ser Trp Ala Pro Pro Val Gly Leu Ser Cys 
    290                 295                 300                 


Gly Pro His Ser Gly Leu Ser Phe Pro Tyr Ser Tyr Glu Val Ala Leu 
305                 310                 315                 320 


Ser Asp Lys Gly Arg Asp Gly Lys Tyr Lys Ile Ile Tyr Ser Gly Glu 
                325                 330                 335     


Glu Leu Glu Cys Asn Leu Lys Asp Leu Arg Pro Ala Thr Asp Tyr His 
            340                 345                 350         


Val Arg Val Tyr Ala Met Tyr Asn Ser Val Lys Gly Ser Cys Ser Glu 
        355                 360                 365             


Pro Val Ser Phe Thr Thr His Ser Cys Ala Pro Glu Cys Pro Phe Pro 
    370                 375                 380                 


Pro Lys Leu Ala His Arg Ser Lys Ser Ser Leu Thr Leu Gln Trp Lys 
385                 390                 395                 400 


Ala Pro Ile Asp Asn Gly Ser Lys Ile Thr Asn Tyr Leu Leu Glu Trp 
                405                 410                 415     


Asp Glu Gly Lys Arg Asn Ser Gly Phe Arg Gln Cys Phe Phe Gly Ser 
            420                 425                 430         


Gln Lys His Cys Lys Leu Thr Lys Leu Cys Pro Ala Met Gly Tyr Thr 
        435                 440                 445             


Phe Arg Leu Ala Ala Arg Asn Asp Ile Gly Thr Ser Gly Tyr Ser Gln 
    450                 455                 460                 


Glu Val Val Cys Tyr Thr Leu Gly Asn Ile Pro Gln Met Pro Ser Ala 
465                 470                 475                 480 


Pro Arg Leu Val Arg Ala Gly Ile Thr Trp Val Thr Leu Gln Trp Ser 
                485                 490                 495     


Lys Pro Glu Gly Cys Ser Pro Glu Glu Val Ile Thr Tyr Thr Leu Glu 
            500                 505                 510         


Ile Gln Glu Asp Glu Asn Asp Asn Leu Phe His Pro Lys Tyr Thr Gly 
        515                 520                 525             


Glu Asp Leu Thr Cys Thr Val Lys Asn Leu Lys Arg Ser Thr Gln Tyr 
    530                 535                 540                 


Lys Phe Arg Leu Thr Ala Ser Asn Thr Glu Gly Lys Ser Cys Pro Ser 
545                 550                 555                 560 


Glu Val Leu Val Cys Thr Thr Ser Pro Asp Arg Pro Gly Pro Pro Thr 
                565                 570                 575     


Arg Pro Leu Val Lys Gly Pro Val Thr Ser His Gly Phe Ser Val Lys 
            580                 585                 590         


Trp Asp Pro Pro Lys Asp Asn Gly Gly Ser Glu Ile Leu Lys Tyr Leu 
        595                 600                 605             


Leu Glu Ile Thr Asp Gly Asn Ser Glu Ala Asn Gln Trp Glu Val Ala 
    610                 615                 620                 


Tyr Ser Gly Ser Ala Thr Glu Tyr Thr Phe Thr His Leu Lys Pro Gly 
625                 630                 635                 640 


Thr Leu Tyr Lys Leu Arg Ala Cys Cys Ile Ser Thr Gly Gly His Ser 
                645                 650                 655     


Gln Cys Ser Glu Ser Leu Pro Val Arg Thr Leu Ser Ile Ala Pro Gly 
            660                 665                 670         


Gln Cys Arg Pro Pro Arg Val Leu Gly Arg Pro Lys His Lys Glu Val 
        675                 680                 685             


His Leu Glu Trp Asp Val Pro Ala Ser Glu Ser Gly Cys Glu Val Ser 
    690                 695                 700                 


Glu Tyr Ser Val Glu Met Thr Glu Pro Glu Asp Val Ala Ser Glu Val 
705                 710                 715                 720 


Tyr His Gly Pro Glu Leu Glu Cys Thr Val Gly Asn Leu Leu Pro Gly 
                725                 730                 735     


Thr Val Tyr Arg Phe Arg Val Arg Ala Leu Asn Asp Gly Gly Tyr Gly 
            740                 745                 750         


Pro Tyr Ser Asp Val Ser Glu Ile Thr Thr Ala Ala Gly Pro Pro Gly 
        755                 760                 765             


Gln Cys Lys Ala Pro Cys Ile Ser Cys Thr Pro Asp Gly Cys Val Leu 
    770                 775                 780                 


Val Gly Trp Glu Ser Pro Asp Ser Ser Gly Ala Asp Ile Ser Glu Tyr 
785                 790                 795                 800 


Arg Leu Glu Trp Gly Glu Asp Glu Glu Ser Leu Glu Leu Ile Tyr His 
                805                 810                 815     


Gly Thr Asp Thr Arg Phe Glu Ile Arg Asp Leu Leu Pro Ala Ala Gln 
            820                 825                 830         


Tyr Cys Cys Arg Leu Gln Ala Phe Asn Gln Ala Gly Ala Gly Pro Tyr 
        835                 840                 845             


Ser Glu Leu Val Leu Cys Gln Thr Pro Ala Ser Ala Pro Asp Pro Val 
    850                 855                 860                 


Ser Thr Leu Cys Val Leu Glu Glu Glu Pro Leu Asp Ala Tyr Pro Asp 
865                 870                 875                 880 


Ser Pro Ser Ala Cys Leu Val Leu Asn Trp Glu Glu Pro Cys Asn Asn 
                885                 890                 895     


Gly Ser Glu Ile Leu Ala Tyr Thr Ile Asp Leu Gly Asp Thr Ser Ile 
            900                 905                 910         


Thr Val Gly Asn Thr Thr Met His Val Met Lys Asp Leu Leu Pro Glu 
        915                 920                 925             


Thr Thr Tyr Arg Ile Arg Ile Gln Ala Ile Asn Glu Ile Gly Ala Gly 
    930                 935                 940                 


Pro Phe Ser Gln Phe Ile Lys Ala Lys Thr Arg Pro Leu Pro Pro Leu 
945                 950                 955                 960 


Pro Pro Arg Leu Glu Cys Ala Ala Ala Gly Pro Gln Ser Leu Lys Leu 
                965                 970                 975     


Lys Trp Gly Asp Ser Asn Ser Lys Thr His Ala Ala Glu Asp Ile Val 
            980                 985                 990         


Tyr Thr Leu Gln Leu Glu Asp Arg  Asn Lys Arg Phe Ile  Ser Ile Tyr 
        995                 1000                 1005             


Arg Gly  Pro Ser His Thr Tyr  Lys Val Gln Arg Leu  Thr Glu Phe 
    1010                 1015                 1020             


Thr Cys  Tyr Ser Phe Arg Ile  Gln Ala Ala Ser Glu  Ala Gly Glu 
    1025                 1030                 1035             


Gly Pro  Phe Ser Glu Thr Tyr  Thr Phe Ser Thr Thr  Lys Ser Val 
    1040                 1045                 1050             


Pro Pro  Thr Ile Lys Ala Pro  Arg Val Thr Gln Leu  Glu Gly Asn 
    1055                 1060                 1065             


Ser Cys  Glu Ile Leu Trp Glu  Thr Val Pro Ser Met  Lys Gly Asp 
    1070                 1075                 1080             


Pro Val  Asn Tyr Ile Leu Gln  Val Leu Val Gly Arg  Glu Ser Glu 
    1085                 1090                 1095             


Tyr Lys  Gln Val Tyr Lys Gly  Glu Glu Ala Thr Phe  Gln Ile Ser 
    1100                 1105                 1110             


Gly Leu  Gln Thr Asn Thr Asp  Tyr Arg Phe Arg Val  Cys Ala Cys 
    1115                 1120                 1125             


Arg Arg  Cys Leu Asp Thr Ser  Gln Glu Leu Ser Gly  Ala Phe Ser 
    1130                 1135                 1140             


Pro Ser  Ala Ala Phe Val Leu  Gln Arg Ser Glu Val  Met Leu Thr 
    1145                 1150                 1155             


Gly Asp  Met Gly Ser Leu Asp  Asp Pro Lys Met Lys  Ser Met Met 
    1160                 1165                 1170             


Pro Thr  Asp Glu Gln Phe Ala  Ala Ile Ile Val Leu  Gly Phe Ala 
    1175                 1180                 1185             


Thr Leu  Ser Ile Leu Phe Ala  Phe Ile Leu Gln Tyr  Phe Leu Met 
    1190                 1195                 1200             


Lys 
    


<210>  102
<211>  1204
<212>  PRT
<213>  Homo sapiens

<400>  102

Met Tyr Val Thr Met Met Met Thr Asp Gln Ile Pro Leu Glu Leu Pro 
1               5                   10                  15      


Pro Leu Leu Asn Gly Glu Val Ala Met Met Pro His Leu Val Asn Gly 
            20                  25                  30          


Asp Ala Ala Gln Gln Val Ile Leu Val Gln Val Asn Pro Gly Glu Thr 
        35                  40                  45              


Phe Thr Ile Arg Ala Glu Asp Gly Thr Leu Gln Cys Ile Gln Gly Pro 
    50                  55                  60                  


Ala Glu Val Pro Met Met Ser Pro Asn Gly Ser Ile Pro Pro Ile His 
65                  70                  75                  80  


Val Pro Pro Gly Tyr Ile Ser Gln Val Ile Glu Asp Ser Thr Gly Val 
                85                  90                  95      


Arg Arg Val Val Val Thr Pro Gln Ser Pro Glu Cys Tyr Pro Pro Ser 
            100                 105                 110         


Tyr Pro Ser Ala Met Ser Pro Thr His His Leu Pro Pro Tyr Leu Thr 
        115                 120                 125             


His His Pro His Phe Ile His Asn Ser His Thr Ala Tyr Tyr Pro Pro 
    130                 135                 140                 


Val Thr Gly Pro Gly Asp Met Pro Pro Gln Phe Phe Pro Gln His His 
145                 150                 155                 160 


Leu Pro His Thr Ile Tyr Gly Glu Gln Glu Ile Ile Pro Phe Tyr Gly 
                165                 170                 175     


Met Ser Thr Tyr Ile Thr Arg Glu Asp Gln Tyr Ser Lys Pro Pro His 
            180                 185                 190         


Lys Lys Leu Lys Asp Arg Gln Ile Asp Arg Gln Asn Arg Leu Asn Ser 
        195                 200                 205             


Pro Pro Ser Ser Ile Tyr Lys Ser Ser Cys Thr Thr Val Tyr Asn Gly 
    210                 215                 220                 


Tyr Gly Lys Gly His Ser Gly Gly Ser Gly Gly Gly Gly Ser Gly Ser 
225                 230                 235                 240 


Gly Pro Gly Ile Lys Lys Thr Glu Arg Arg Ala Arg Ser Ser Pro Lys 
                245                 250                 255     


Ser Asn Asp Ser Asp Leu Gln Glu Tyr Glu Leu Glu Val Lys Arg Val 
            260                 265                 270         


Gln Asp Ile Leu Ser Gly Ile Glu Lys Pro Gln Val Ser Asn Ile Gln 
        275                 280                 285             


Ala Arg Ala Val Val Leu Ser Trp Ala Pro Pro Val Gly Leu Ser Cys 
    290                 295                 300                 


Gly Pro His Ser Gly Leu Ser Phe Pro Tyr Ser Tyr Glu Val Ala Leu 
305                 310                 315                 320 


Ser Asp Lys Gly Arg Asp Gly Lys Tyr Lys Ile Ile Tyr Ser Gly Glu 
                325                 330                 335     


Glu Leu Glu Cys Asn Leu Lys Asp Leu Arg Pro Ala Thr Asp Tyr His 
            340                 345                 350         


Val Arg Val Tyr Ala Met Tyr Asn Ser Val Lys Gly Ser Cys Ser Glu 
        355                 360                 365             


Pro Val Ser Phe Thr Thr His Ser Cys Ala Pro Glu Cys Pro Phe Pro 
    370                 375                 380                 


Pro Lys Leu Ala His Arg Ser Lys Ser Ser Leu Thr Leu Gln Trp Lys 
385                 390                 395                 400 


Ala Pro Ile Asp Asn Gly Ser Lys Ile Thr Asn Tyr Leu Leu Glu Trp 
                405                 410                 415     


Asp Glu Gly Lys Arg Asn Ser Gly Phe Arg Gln Cys Phe Phe Gly Ser 
            420                 425                 430         


Gln Lys His Cys Lys Leu Thr Lys Leu Cys Pro Ala Met Gly Tyr Thr 
        435                 440                 445             


Phe Arg Leu Ala Ala Arg Asn Asp Ile Gly Thr Ser Gly Tyr Ser Gln 
    450                 455                 460                 


Glu Val Val Cys Tyr Thr Leu Gly Asn Ile Pro Gln Met Pro Ser Ala 
465                 470                 475                 480 


Pro Arg Leu Val Arg Ala Gly Ile Thr Trp Val Thr Leu Gln Trp Ser 
                485                 490                 495     


Lys Pro Glu Gly Cys Ser Pro Glu Glu Val Ile Thr Tyr Thr Leu Glu 
            500                 505                 510         


Ile Gln Glu Asp Glu Asn Asp Asn Leu Phe His Pro Lys Tyr Thr Gly 
        515                 520                 525             


Glu Asp Leu Thr Cys Thr Val Lys Asn Leu Lys Arg Ser Thr Gln Tyr 
    530                 535                 540                 


Lys Phe Arg Leu Thr Ala Ser Asn Thr Glu Gly Lys Ser Cys Pro Ser 
545                 550                 555                 560 


Glu Val Leu Val Cys Thr Thr Ser Pro Asp Arg Pro Gly Pro Pro Thr 
                565                 570                 575     


Arg Pro Leu Val Lys Gly Pro Val Thr Ser His Gly Phe Ser Val Lys 
            580                 585                 590         


Trp Asp Pro Pro Lys Asp Asn Gly Gly Ser Glu Ile Leu Lys Tyr Leu 
        595                 600                 605             


Leu Glu Ile Thr Asp Gly Asn Ser Glu Ala Asn Gln Trp Glu Val Ala 
    610                 615                 620                 


Tyr Ser Gly Ser Ala Thr Glu Tyr Thr Phe Thr His Leu Lys Pro Gly 
625                 630                 635                 640 


Thr Leu Tyr Lys Leu Arg Ala Cys Cys Ile Ser Thr Gly Gly His Ser 
                645                 650                 655     


Gln Cys Ser Glu Ser Leu Pro Val Arg Thr Leu Ser Ile Ala Pro Gly 
            660                 665                 670         


Gln Cys Arg Pro Pro Arg Val Leu Gly Arg Pro Lys His Lys Glu Val 
        675                 680                 685             


His Leu Glu Trp Asp Val Pro Ala Ser Glu Ser Gly Cys Glu Val Ser 
    690                 695                 700                 


Glu Tyr Ser Val Glu Met Thr Glu Pro Glu Asp Val Ala Ser Glu Val 
705                 710                 715                 720 


Tyr His Gly Pro Glu Leu Glu Cys Thr Val Gly Asn Leu Leu Pro Gly 
                725                 730                 735     


Thr Val Tyr Arg Phe Arg Val Arg Ala Leu Asn Asp Gly Gly Tyr Gly 
            740                 745                 750         


Pro Tyr Ser Asp Val Ser Glu Ile Thr Thr Ala Ala Gly Pro Pro Gly 
        755                 760                 765             


Gln Cys Lys Ala Pro Cys Ile Ser Cys Thr Pro Asp Gly Cys Val Leu 
    770                 775                 780                 


Val Gly Trp Glu Ser Pro Asp Ser Ser Gly Ala Asp Ile Ser Glu Tyr 
785                 790                 795                 800 


Arg Leu Glu Trp Gly Glu Asp Glu Glu Ser Leu Glu Leu Ile Tyr His 
                805                 810                 815     


Gly Thr Asp Thr Arg Phe Glu Ile Arg Asp Leu Leu Pro Ala Ala Gln 
            820                 825                 830         


Tyr Cys Cys Arg Leu Gln Ala Phe Asn Gln Ala Gly Ala Gly Pro Tyr 
        835                 840                 845             


Ser Glu Leu Val Leu Cys Gln Thr Pro Ala Ser Ala Pro Asp Pro Val 
    850                 855                 860                 


Ser Thr Leu Cys Val Leu Glu Glu Glu Pro Leu Asp Ala Tyr Pro Asp 
865                 870                 875                 880 


Ser Pro Ser Ala Cys Leu Val Leu Asn Trp Glu Glu Pro Cys Asn Asn 
                885                 890                 895     


Gly Ser Glu Ile Leu Ala Tyr Thr Ile Asp Leu Gly Asp Thr Ser Ile 
            900                 905                 910         


Thr Val Gly Asn Thr Thr Met His Val Met Lys Asp Leu Leu Pro Glu 
        915                 920                 925             


Thr Thr Tyr Arg Ile Arg Ile Gln Ala Ile Asn Glu Ile Gly Ala Gly 
    930                 935                 940                 


Pro Phe Ser Gln Phe Ile Lys Ala Lys Thr Arg Pro Leu Pro Pro Leu 
945                 950                 955                 960 


Pro Pro Arg Leu Glu Cys Ala Ala Ala Gly Pro Gln Ser Leu Lys Leu 
                965                 970                 975     


Lys Trp Gly Asp Ser Asn Ser Lys Thr His Ala Ala Glu Asp Ile Val 
            980                 985                 990         


Tyr Thr Leu Gln Leu Glu Asp Arg  Asn Lys Arg Phe Ile  Ser Ile Tyr 
        995                 1000                 1005             


Arg Gly  Pro Ser His Thr Tyr  Lys Val Gln Arg Leu  Thr Glu Phe 
    1010                 1015                 1020             


Thr Cys  Tyr Ser Phe Arg Ile  Gln Ala Ala Ser Glu  Ala Gly Glu 
    1025                 1030                 1035             


Gly Pro  Phe Ser Glu Thr Tyr  Thr Phe Ser Thr Thr  Lys Ser Val 
    1040                 1045                 1050             


Pro Pro  Thr Ile Lys Ala Pro  Arg Val Thr Gln Leu  Glu Gly Asn 
    1055                 1060                 1065             


Ser Cys  Glu Ile Leu Trp Glu  Thr Val Pro Ser Met  Lys Gly Asp 
    1070                 1075                 1080             


Pro Val  Asn Tyr Ile Leu Gln  Val Leu Val Gly Arg  Glu Ser Glu 
    1085                 1090                 1095             


Tyr Lys  Gln Val Tyr Lys Gly  Glu Glu Ala Thr Phe  Gln Ile Ser 
    1100                 1105                 1110             


Gly Leu  Gln Thr Asn Thr Asp  Tyr Arg Phe Arg Val  Cys Ala Cys 
    1115                 1120                 1125             


Arg Arg  Cys Leu Asp Thr Ser  Gln Glu Leu Ser Gly  Ala Phe Ser 
    1130                 1135                 1140             


Pro Ser  Ala Ala Phe Val Leu  Gln Arg Ser Glu Val  Met Leu Thr 
    1145                 1150                 1155             


Gly Asp  Met Gly Ser Leu Asp  Asp Pro Lys Met Lys  Ser Met Met 
    1160                 1165                 1170             


Pro Thr  Asp Glu Gln Phe Ala  Ala Ile Ile Val Leu  Gly Phe Ala 
    1175                 1180                 1185             


Thr Leu  Ser Ile Leu Phe Ala  Phe Ile Leu Gln Tyr  Phe Leu Met 
    1190                 1195                 1200             


Lys 
    


<210>  103
<211>  71
<212>  PRT
<213>  Homo sapiens

<400>  103

Met Tyr Val Thr Met Met Met Thr Asp Gln Ile Pro Leu Glu Leu Pro 
1               5                   10                  15      


Pro Leu Leu Asn Gly Glu Val Ala Met Met Pro His Leu Val Asn Gly 
            20                  25                  30          


Asp Ala Ala Gln Gln Val Ile Leu Val Gln Val Asn Pro Gly Glu Thr 
        35                  40                  45              


Phe Thr Ile Arg Ala Glu Asp Gly Thr Leu Gln Cys Ile Gln Asp Glu 
    50                  55                  60                  


Val Val Lys Arg Ala Cys Asp 
65                  70      


<210>  104
<211>  71
<212>  PRT
<213>  Homo sapiens

<400>  104

Met Tyr Val Thr Met Met Met Thr Asp Gln Ile Pro Leu Glu Leu Pro 
1               5                   10                  15      


Pro Leu Leu Asn Gly Glu Val Ala Met Met Pro His Leu Val Asn Gly 
            20                  25                  30          


Asp Ala Ala Gln Gln Val Ile Leu Val Gln Val Asn Pro Gly Glu Thr 
        35                  40                  45              


Phe Thr Ile Arg Ala Glu Asp Gly Thr Leu Gln Cys Ile Gln Asp Glu 
    50                  55                  60                  


Val Val Lys Arg Ala Cys Asp 
65                  70      


<210>  105
<211>  862
<212>  PRT
<213>  Homo sapiens

<400>  105

Met Ala His Thr Phe Arg Gly Cys Ser Leu Ala Phe Met Phe Ile Ile 
1               5                   10                  15      


Thr Trp Leu Leu Ile Lys Ala Lys Ile Asp Ala Cys Lys Arg Gly Asp 
            20                  25                  30          


Val Thr Val Lys Pro Ser His Val Ile Leu Leu Gly Ser Thr Val Asn 
        35                  40                  45              


Ile Thr Cys Ser Leu Lys Pro Arg Gln Gly Cys Phe His Tyr Ser Arg 
    50                  55                  60                  


Arg Asn Lys Leu Ile Leu Tyr Lys Phe Asp Arg Arg Ile Asn Phe His 
65                  70                  75                  80  


His Gly His Ser Leu Asn Ser Gln Val Thr Gly Leu Pro Leu Gly Thr 
                85                  90                  95      


Thr Leu Phe Val Cys Lys Leu Ala Cys Ile Asn Ser Asp Glu Ile Gln 
            100                 105                 110         


Ile Cys Gly Ala Glu Ile Phe Val Gly Val Ala Pro Glu Gln Pro Gln 
        115                 120                 125             


Asn Leu Ser Cys Ile Gln Lys Gly Glu Gln Gly Thr Val Ala Cys Thr 
    130                 135                 140                 


Trp Glu Arg Gly Arg Asp Thr His Leu Tyr Thr Glu Tyr Thr Leu Gln 
145                 150                 155                 160 


Leu Ser Gly Pro Lys Asn Leu Thr Trp Gln Lys Gln Cys Lys Asp Ile 
                165                 170                 175     


Tyr Cys Asp Tyr Leu Asp Phe Gly Ile Asn Leu Thr Pro Glu Ser Pro 
            180                 185                 190         


Glu Ser Asn Phe Thr Ala Lys Val Thr Ala Val Asn Ser Leu Gly Ser 
        195                 200                 205             


Ser Ser Ser Leu Pro Ser Thr Phe Thr Phe Leu Asp Ile Val Arg Pro 
    210                 215                 220                 


Leu Pro Pro Trp Asp Ile Arg Ile Lys Phe Gln Lys Ala Ser Val Ser 
225                 230                 235                 240 


Arg Cys Thr Leu Tyr Trp Arg Asp Glu Gly Leu Val Leu Leu Asn Arg 
                245                 250                 255     


Leu Arg Tyr Arg Pro Ser Asn Ser Arg Leu Trp Asn Met Val Asn Val 
            260                 265                 270         


Thr Lys Ala Lys Gly Arg His Asp Leu Leu Asp Leu Lys Pro Phe Thr 
        275                 280                 285             


Glu Tyr Glu Phe Gln Ile Ser Ser Lys Leu His Leu Tyr Lys Gly Ser 
    290                 295                 300                 


Trp Ser Asp Trp Ser Glu Ser Leu Arg Ala Gln Thr Pro Glu Glu Glu 
305                 310                 315                 320 


Pro Thr Gly Met Leu Asp Val Trp Tyr Met Lys Arg His Ile Asp Tyr 
                325                 330                 335     


Ser Arg Gln Gln Ile Ser Leu Phe Trp Lys Asn Leu Ser Val Ser Glu 
            340                 345                 350         


Ala Arg Gly Lys Ile Leu His Tyr Gln Val Thr Leu Gln Glu Leu Thr 
        355                 360                 365             


Gly Gly Lys Ala Met Thr Gln Asn Ile Thr Gly His Thr Ser Trp Thr 
    370                 375                 380                 


Thr Val Ile Pro Arg Thr Gly Asn Trp Ala Val Ala Val Ser Ala Ala 
385                 390                 395                 400 


Asn Ser Lys Gly Ser Ser Leu Pro Thr Arg Ile Asn Ile Met Asn Leu 
                405                 410                 415     


Cys Glu Ala Gly Leu Leu Ala Pro Arg Gln Val Ser Ala Asn Ser Glu 
            420                 425                 430         


Gly Met Asp Asn Ile Leu Val Thr Trp Gln Pro Pro Arg Lys Asp Pro 
        435                 440                 445             


Ser Ala Val Gln Glu Tyr Val Val Glu Trp Arg Glu Leu His Pro Gly 
    450                 455                 460                 


Gly Asp Thr Gln Val Pro Leu Asn Trp Leu Arg Ser Arg Pro Tyr Asn 
465                 470                 475                 480 


Val Ser Ala Leu Ile Ser Glu Asn Ile Lys Ser Tyr Ile Cys Tyr Glu 
                485                 490                 495     


Ile Arg Val Tyr Ala Leu Ser Gly Asp Gln Gly Gly Cys Ser Ser Ile 
            500                 505                 510         


Leu Gly Asn Ser Lys His Lys Ala Pro Leu Ser Gly Pro His Ile Asn 
        515                 520                 525             


Ala Ile Thr Glu Glu Lys Gly Ser Ile Leu Ile Ser Trp Asn Ser Ile 
    530                 535                 540                 


Pro Val Gln Glu Gln Met Gly Cys Leu Leu His Tyr Arg Ile Tyr Trp 
545                 550                 555                 560 


Lys Glu Arg Asp Ser Asn Ser Gln Pro Gln Leu Cys Glu Ile Pro Tyr 
                565                 570                 575     


Arg Val Ser Gln Asn Ser His Pro Ile Asn Ser Leu Gln Pro Arg Val 
            580                 585                 590         


Thr Tyr Val Leu Trp Met Thr Ala Leu Thr Ala Ala Gly Glu Ser Ser 
        595                 600                 605             


His Gly Asn Glu Arg Glu Phe Cys Leu Gln Gly Lys Ala Asn Trp Met 
    610                 615                 620                 


Ala Phe Val Ala Pro Ser Ile Cys Ile Ala Ile Ile Met Val Gly Ile 
625                 630                 635                 640 


Phe Ser Thr His Tyr Phe Gln Gln Lys Val Phe Val Leu Leu Ala Ala 
                645                 650                 655     


Leu Arg Pro Gln Trp Cys Ser Arg Glu Ile Pro Asp Pro Ala Asn Ser 
            660                 665                 670         


Thr Cys Ala Lys Lys Tyr Pro Ile Ala Glu Glu Lys Thr Gln Leu Pro 
        675                 680                 685             


Leu Asp Arg Leu Leu Ile Asp Trp Pro Thr Pro Glu Asp Pro Glu Pro 
    690                 695                 700                 


Leu Val Ile Ser Glu Val Leu His Gln Val Thr Pro Val Phe Arg His 
705                 710                 715                 720 


Pro Pro Cys Ser Asn Trp Pro Gln Arg Glu Lys Gly Ile Gln Gly His 
                725                 730                 735     


Gln Ala Ser Glu Lys Asp Met Met His Ser Ala Ser Ser Pro Pro Pro 
            740                 745                 750         


Pro Arg Ala Leu Gln Ala Glu Ser Arg Gln Leu Val Asp Leu Tyr Lys 
        755                 760                 765             


Val Leu Glu Ser Arg Gly Ser Asp Pro Lys Pro Glu Asn Pro Ala Cys 
    770                 775                 780                 


Pro Trp Thr Val Leu Pro Ala Gly Asp Leu Pro Thr His Asp Gly Tyr 
785                 790                 795                 800 


Leu Pro Ser Asn Ile Asp Asp Leu Pro Ser His Glu Ala Pro Leu Ala 
                805                 810                 815     


Asp Ser Leu Glu Glu Leu Glu Pro Gln His Ile Ser Leu Ser Val Phe 
            820                 825                 830         


Pro Ser Ser Ser Leu His Pro Leu Thr Phe Ser Cys Gly Asp Lys Leu 
        835                 840                 845             


Thr Leu Asp Gln Leu Lys Met Arg Cys Asp Ser Leu Met Leu 
    850                 855                 860         


<210>  106
<211>  659
<212>  PRT
<213>  Homo sapiens

<400>  106

Met Ala His Thr Phe Arg Gly Cys Ser Leu Ala Phe Met Phe Ile Ile 
1               5                   10                  15      


Thr Trp Leu Leu Ile Lys Ala Lys Ile Asp Ala Cys Lys Arg Gly Asp 
            20                  25                  30          


Val Thr Val Lys Pro Ser His Val Ile Leu Leu Gly Ser Thr Val Asn 
        35                  40                  45              


Ile Thr Cys Ser Leu Lys Pro Arg Gln Gly Cys Phe His Tyr Ser Arg 
    50                  55                  60                  


Arg Asn Lys Leu Ile Leu Tyr Lys Phe Asp Arg Arg Ile Asn Phe His 
65                  70                  75                  80  


His Gly His Ser Leu Asn Ser Gln Val Thr Gly Leu Pro Leu Gly Thr 
                85                  90                  95      


Thr Leu Phe Val Cys Lys Leu Ala Cys Ile Asn Ser Asp Glu Ile Gln 
            100                 105                 110         


Ile Cys Gly Ala Glu Ile Phe Val Gly Val Ala Pro Glu Gln Pro Gln 
        115                 120                 125             


Asn Leu Ser Cys Ile Gln Lys Gly Glu Gln Gly Thr Val Ala Cys Thr 
    130                 135                 140                 


Trp Glu Arg Gly Arg Asp Thr His Leu Tyr Thr Glu Tyr Thr Leu Gln 
145                 150                 155                 160 


Leu Ser Gly Pro Lys Asn Leu Thr Trp Gln Lys Gln Cys Lys Asp Ile 
                165                 170                 175     


Tyr Cys Asp Tyr Leu Asp Phe Gly Ile Asn Leu Thr Pro Glu Ser Pro 
            180                 185                 190         


Glu Ser Asn Phe Thr Ala Lys Val Thr Ala Val Asn Ser Leu Gly Ser 
        195                 200                 205             


Ser Ser Ser Leu Pro Ser Thr Phe Thr Phe Leu Asp Ile Val Arg Pro 
    210                 215                 220                 


Leu Pro Pro Trp Asp Ile Arg Ile Lys Phe Gln Lys Ala Ser Val Ser 
225                 230                 235                 240 


Arg Cys Thr Leu Tyr Trp Arg Asp Glu Gly Leu Val Leu Leu Asn Arg 
                245                 250                 255     


Leu Arg Tyr Arg Pro Ser Asn Ser Arg Leu Trp Asn Met Val Asn Val 
            260                 265                 270         


Thr Lys Ala Lys Gly Arg His Asp Leu Leu Asp Leu Lys Pro Phe Thr 
        275                 280                 285             


Glu Tyr Glu Phe Gln Ile Ser Ser Lys Leu His Leu Tyr Lys Gly Ser 
    290                 295                 300                 


Trp Ser Asp Trp Ser Glu Ser Leu Arg Ala Gln Thr Pro Glu Glu Glu 
305                 310                 315                 320 


Pro Thr Gly Met Leu Asp Val Trp Tyr Met Lys Arg His Ile Asp Tyr 
                325                 330                 335     


Ser Arg Gln Gln Ile Ser Leu Phe Trp Lys Asn Leu Ser Val Ser Glu 
            340                 345                 350         


Ala Arg Gly Lys Ile Leu His Tyr Gln Val Thr Leu Gln Glu Leu Thr 
        355                 360                 365             


Gly Gly Lys Ala Met Thr Gln Asn Ile Thr Gly His Thr Ser Trp Thr 
    370                 375                 380                 


Thr Val Ile Pro Arg Thr Gly Asn Trp Ala Val Ala Val Ser Ala Ala 
385                 390                 395                 400 


Asn Ser Lys Gly Ser Ser Leu Pro Thr Arg Ile Asn Ile Met Asn Leu 
                405                 410                 415     


Cys Glu Ala Gly Leu Leu Ala Pro Arg Gln Val Ser Ala Asn Ser Glu 
            420                 425                 430         


Gly Met Asp Asn Ile Leu Val Thr Trp Gln Pro Pro Arg Lys Asp Pro 
        435                 440                 445             


Ser Ala Val Gln Glu Tyr Val Val Glu Trp Arg Glu Leu His Pro Gly 
    450                 455                 460                 


Gly Asp Thr Gln Val Pro Leu Asn Trp Leu Arg Ser Arg Pro Tyr Asn 
465                 470                 475                 480 


Val Ser Ala Leu Ile Ser Glu Asn Ile Lys Ser Tyr Ile Cys Tyr Glu 
                485                 490                 495     


Ile Arg Val Tyr Ala Leu Ser Gly Asp Gln Gly Gly Cys Ser Ser Ile 
            500                 505                 510         


Leu Gly Asn Ser Lys His Lys Ala Pro Leu Ser Gly Pro His Ile Asn 
        515                 520                 525             


Ala Ile Thr Glu Glu Lys Gly Ser Ile Leu Ile Ser Trp Asn Ser Ile 
    530                 535                 540                 


Pro Val Gln Glu Gln Met Gly Cys Leu Leu His Tyr Arg Ile Tyr Trp 
545                 550                 555                 560 


Lys Glu Arg Asp Ser Asn Ser Gln Pro Gln Leu Cys Glu Ile Pro Tyr 
                565                 570                 575     


Arg Val Ser Gln Asn Ser His Pro Ile Asn Ser Leu Gln Pro Arg Val 
            580                 585                 590         


Thr Tyr Val Leu Trp Met Thr Ala Leu Thr Ala Ala Gly Glu Ser Ser 
        595                 600                 605             


His Gly Asn Glu Arg Glu Phe Cys Leu Gln Gly Lys Ala Asn Trp Met 
    610                 615                 620                 


Ala Phe Val Ala Pro Ser Ile Cys Ile Ala Ile Ile Met Val Gly Ile 
625                 630                 635                 640 


Phe Ser Thr His Tyr Phe Gln Gln Lys Arg Arg His Ser Cys Pro Trp 
                645                 650                 655     


Thr Gly Ser 
            


<210>  107
<211>  230
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  107

Xaa Gln Lys Gly Glu Gln Gly Thr Val Ala Cys Thr Trp Glu Arg Gly 
1               5                   10                  15      


Arg Asp Thr His Leu Tyr Thr Glu Tyr Thr Leu Gln Leu Ser Gly Pro 
            20                  25                  30          


Lys Asn Leu Thr Trp Gln Lys Gln Cys Lys Asp Ile Tyr Cys Asp Tyr 
        35                  40                  45              


Leu Asp Phe Gly Ile Asn Leu Thr Pro Glu Ser Pro Glu Ser Asn Phe 
    50                  55                  60                  


Thr Ala Lys Val Thr Ala Val Asn Ser Leu Gly Ser Ser Ser Ser Leu 
65                  70                  75                  80  


Pro Ser Thr Phe Thr Phe Leu Asp Ile Val Arg Pro Leu Pro Pro Trp 
                85                  90                  95      


Asp Ile Arg Ile Lys Phe Gln Lys Ala Ser Val Ser Arg Cys Thr Leu 
            100                 105                 110         


Tyr Trp Arg Asp Glu Gly Leu Val Leu Leu Asn Arg Leu Arg Tyr Arg 
        115                 120                 125             


Pro Ser Asn Ser Arg Leu Trp Asn Met Val Asn Val Thr Lys Ala Lys 
    130                 135                 140                 


Gly Arg His Asp Leu Leu Asp Leu Lys Pro Phe Thr Glu Tyr Glu Phe 
145                 150                 155                 160 


Gln Ile Ser Ser Lys Leu His Leu Tyr Lys Gly Ser Trp Ser Asp Trp 
                165                 170                 175     


Ser Glu Ser Leu Arg Ala Gln Thr Pro Glu Glu Glu Pro Thr Gly Met 
            180                 185                 190         


Leu Asp Val Trp Tyr Met Lys Arg His Ile Asp Tyr Ser Arg Gln Gln 
        195                 200                 205             


Ile Ser Leu Phe Trp Lys Val Ser Phe Lys Arg Gln Leu Lys Thr Gln 
    210                 215                 220                 


Gly Asn Lys Thr Glu Gly 
225                 230 


<210>  108
<211>  635
<212>  PRT
<213>  Homo sapiens

<400>  108

Met Ala His Thr Phe Arg Gly Cys Ser Leu Ala Phe Met Phe Ile Ile 
1               5                   10                  15      


Thr Trp Leu Leu Ile Lys Ala Lys Ile Asp Ala Cys Lys Arg Gly Asp 
            20                  25                  30          


Val Thr Val Lys Pro Ser His Val Ile Leu Leu Gly Ser Thr Val Asn 
        35                  40                  45              


Ile Thr Cys Ser Leu Lys Pro Arg Gln Gly Cys Phe His Tyr Ser Arg 
    50                  55                  60                  


Arg Asn Lys Leu Ile Leu Tyr Lys Phe Asp Arg Arg Ile Asn Phe His 
65                  70                  75                  80  


His Gly His Ser Leu Asn Ser Gln Val Thr Gly Leu Pro Leu Gly Thr 
                85                  90                  95      


Thr Leu Phe Val Cys Lys Leu Ala Cys Ile Asn Ser Asp Glu Ile Gln 
            100                 105                 110         


Ile Cys Gly Ala Glu Ile Phe Val Gly Val Ala Pro Glu Gln Pro Gln 
        115                 120                 125             


Asn Leu Ser Cys Ile Gln Lys Gly Glu Gln Gly Thr Val Ala Cys Thr 
    130                 135                 140                 


Trp Glu Arg Gly Arg Asp Thr His Leu Tyr Thr Glu Tyr Thr Leu Gln 
145                 150                 155                 160 


Leu Ser Gly Pro Lys Asn Leu Thr Trp Gln Lys Gln Cys Lys Asp Ile 
                165                 170                 175     


Tyr Cys Asp Tyr Leu Asp Phe Gly Ile Asn Leu Thr Pro Glu Ser Pro 
            180                 185                 190         


Glu Ser Asn Phe Thr Ala Lys Val Thr Ala Val Asn Ser Leu Gly Ser 
        195                 200                 205             


Ser Ser Ser Leu Pro Ser Thr Phe Thr Phe Leu Asp Ile Val Arg Pro 
    210                 215                 220                 


Leu Pro Pro Trp Asp Ile Arg Ile Lys Phe Gln Lys Ala Ser Val Ser 
225                 230                 235                 240 


Arg Cys Thr Leu Tyr Trp Arg Asp Glu Gly Leu Val Leu Leu Asn Arg 
                245                 250                 255     


Leu Arg Tyr Arg Pro Ser Asn Ser Arg Leu Trp Asn Met Val Asn Val 
            260                 265                 270         


Thr Lys Ala Lys Gly Arg His Asp Leu Leu Asp Leu Lys Pro Phe Thr 
        275                 280                 285             


Glu Tyr Glu Phe Gln Ile Ser Ser Lys Leu His Leu Tyr Lys Gly Ser 
    290                 295                 300                 


Trp Ser Asp Trp Ser Glu Ser Leu Arg Ala Gln Thr Pro Glu Glu Glu 
305                 310                 315                 320 


Pro Thr Gly Met Leu Asp Val Trp Tyr Met Lys Arg His Ile Asp Tyr 
                325                 330                 335     


Ser Arg Gln Gln Ile Ser Leu Phe Trp Lys Asn Leu Ser Val Ser Glu 
            340                 345                 350         


Ala Arg Gly Lys Ile Leu His Tyr Gln Val Thr Leu Gln Glu Leu Thr 
        355                 360                 365             


Gly Gly Lys Ala Met Thr Gln Asn Ile Thr Gly His Thr Ser Trp Thr 
    370                 375                 380                 


Thr Val Ile Pro Arg Thr Gly Asn Trp Ala Val Ala Val Ser Ala Ala 
385                 390                 395                 400 


Asn Ser Lys Gly Ser Ser Leu Pro Thr Arg Ile Asn Ile Met Asn Leu 
                405                 410                 415     


Cys Glu Ala Gly Leu Leu Ala Pro Arg Gln Val Ser Ala Asn Ser Glu 
            420                 425                 430         


Gly Met Asp Asn Ile Leu Val Thr Trp Gln Pro Pro Arg Lys Asp Pro 
        435                 440                 445             


Ser Ala Val Gln Glu Tyr Val Val Glu Trp Arg Glu Leu His Pro Gly 
    450                 455                 460                 


Gly Asp Thr Gln Val Pro Leu Asn Trp Leu Arg Ser Arg Pro Tyr Asn 
465                 470                 475                 480 


Val Ser Ala Leu Ile Ser Glu Asn Ile Lys Ser Tyr Ile Cys Tyr Glu 
                485                 490                 495     


Ile Arg Val Tyr Ala Leu Ser Gly Asp Gln Gly Gly Cys Ser Ser Ile 
            500                 505                 510         


Leu Gly Asn Ser Lys His Lys Ala Pro Leu Ser Gly Pro His Ile Asn 
        515                 520                 525             


Ala Ile Thr Glu Glu Lys Gly Ser Ile Leu Ile Ser Trp Asn Ser Ile 
    530                 535                 540                 


Pro Val Gln Glu Gln Met Gly Cys Leu Leu His Tyr Arg Ile Tyr Trp 
545                 550                 555                 560 


Lys Glu Arg Asp Ser Asn Ser Gln Pro Gln Leu Cys Glu Ile Pro Tyr 
                565                 570                 575     


Arg Val Ser Gln Asn Ser His Pro Ile Asn Ser Leu Gln Pro Arg Val 
            580                 585                 590         


Thr Tyr Val Leu Trp Met Thr Ala Leu Thr Ala Ala Gly Glu Ser Ser 
        595                 600                 605             


His Gly Asn Glu Arg Glu Phe Cys Leu Gln Gly Glu Asp Thr Ala Ala 
    610                 615                 620                 


Leu Gly Gln Ala Pro Asp Arg Leu Ala His Ala 
625                 630                 635 


<210>  109
<211>  776
<212>  PRT
<213>  Homo sapiens

<400>  109

Met Ala His Thr Phe Arg Gly Cys Ser Leu Ala Phe Met Phe Ile Ile 
1               5                   10                  15      


Thr Trp Leu Leu Ile Lys Ala Lys Ile Asp Ala Cys Lys Arg Gly Asp 
            20                  25                  30          


Val Thr Val Lys Pro Ser His Val Ile Leu Leu Gly Ser Thr Val Asn 
        35                  40                  45              


Ile Thr Cys Ser Leu Lys Pro Arg Gln Gly Cys Phe His Tyr Ser Arg 
    50                  55                  60                  


Arg Asn Lys Leu Ile Leu Tyr Lys Phe Asp Arg Arg Ile Asn Phe His 
65                  70                  75                  80  


His Gly His Ser Leu Asn Ser Gln Val Thr Gly Leu Pro Leu Gly Thr 
                85                  90                  95      


Thr Leu Phe Val Cys Lys Leu Ala Cys Ile Asn Ser Asp Glu Ile Gln 
            100                 105                 110         


Ile Cys Gly Ala Glu Ile Phe Val Gly Val Ala Pro Glu Gln Pro Gln 
        115                 120                 125             


Asn Leu Ser Cys Ile Gln Lys Gly Glu Gln Gly Thr Val Ala Cys Thr 
    130                 135                 140                 


Trp Glu Arg Gly Arg Asp Thr His Leu Tyr Thr Glu Tyr Thr Leu Gln 
145                 150                 155                 160 


Leu Ser Gly Pro Lys Asn Leu Thr Trp Gln Lys Gln Cys Lys Asp Ile 
                165                 170                 175     


Tyr Cys Asp Tyr Leu Asp Phe Gly Ile Asn Leu Thr Pro Glu Ser Pro 
            180                 185                 190         


Glu Ser Asn Phe Thr Ala Lys Val Thr Ala Val Asn Ser Leu Gly Ser 
        195                 200                 205             


Ser Ser Ser Leu Pro Ser Thr Phe Thr Phe Leu Asp Ile Val Arg Pro 
    210                 215                 220                 


Leu Pro Pro Trp Asp Ile Arg Ile Lys Phe Gln Lys Ala Ser Val Ser 
225                 230                 235                 240 


Arg Cys Thr Leu Tyr Trp Arg Asp Glu Gly Leu Val Leu Leu Asn Arg 
                245                 250                 255     


Leu Arg Tyr Arg Pro Ser Asn Ser Arg Leu Trp Asn Met Val Asn Val 
            260                 265                 270         


Thr Lys Ala Lys Gly Arg His Asp Leu Leu Asp Leu Lys Pro Phe Thr 
        275                 280                 285             


Glu Tyr Glu Phe Gln Ile Ser Ser Lys Leu His Leu Tyr Lys Gly Ser 
    290                 295                 300                 


Trp Ser Asp Trp Ser Glu Ser Leu Arg Ala Gln Thr Pro Glu Glu Glu 
305                 310                 315                 320 


Pro Thr Gly Met Leu Asp Val Trp Tyr Met Lys Arg His Ile Asp Tyr 
                325                 330                 335     


Ser Arg Gln Gln Ile Ser Leu Phe Trp Lys Asn Leu Ser Val Ser Glu 
            340                 345                 350         


Ala Arg Gly Lys Ile Leu His Tyr Gln Val Thr Leu Gln Glu Leu Thr 
        355                 360                 365             


Gly Gly Lys Ala Met Thr Gln Asn Ile Thr Gly His Thr Ser Trp Thr 
    370                 375                 380                 


Thr Val Ile Pro Arg Thr Gly Asn Trp Ala Val Ala Val Ser Ala Ala 
385                 390                 395                 400 


Asn Ser Lys Gly Ser Ser Leu Pro Thr Arg Ile Asn Ile Met Asn Leu 
                405                 410                 415     


Cys Glu Ala Gly Leu Leu Ala Pro Arg Gln Val Ser Ala Asn Ser Glu 
            420                 425                 430         


Gly Met Asp Asn Ile Leu Val Thr Trp Gln Pro Pro Arg Lys Asp Pro 
        435                 440                 445             


Ser Ala Val Gln Glu Tyr Val Val Glu Trp Arg Glu Leu His Pro Gly 
    450                 455                 460                 


Gly Asp Thr Gln Val Pro Leu Asn Trp Leu Arg Ser Arg Pro Tyr Asn 
465                 470                 475                 480 


Val Ser Ala Leu Ile Ser Glu Ile Pro Tyr Arg Val Ser Gln Asn Ser 
                485                 490                 495     


His Pro Ile Asn Ser Leu Gln Pro Arg Val Thr Tyr Val Leu Trp Met 
            500                 505                 510         


Thr Ala Leu Thr Ala Ala Gly Glu Ser Ser His Gly Asn Glu Arg Glu 
        515                 520                 525             


Phe Cys Leu Gln Gly Lys Ala Asn Trp Met Ala Phe Val Ala Pro Ser 
    530                 535                 540                 


Ile Cys Ile Ala Ile Ile Met Val Gly Ile Phe Ser Thr His Tyr Phe 
545                 550                 555                 560 


Gln Gln Lys Val Phe Val Leu Leu Ala Ala Leu Arg Pro Gln Trp Cys 
                565                 570                 575     


Ser Arg Glu Ile Pro Asp Pro Ala Asn Ser Thr Cys Ala Lys Lys Tyr 
            580                 585                 590         


Pro Ile Ala Glu Glu Lys Thr Gln Leu Pro Leu Asp Arg Leu Leu Ile 
        595                 600                 605             


Asp Trp Pro Thr Pro Glu Asp Pro Glu Pro Leu Val Ile Ser Glu Val 
    610                 615                 620                 


Leu His Gln Val Thr Pro Val Phe Arg His Pro Pro Cys Ser Asn Trp 
625                 630                 635                 640 


Pro Gln Arg Glu Lys Gly Ile Gln Gly His Gln Ala Ser Glu Lys Asp 
                645                 650                 655     


Met Met His Ser Ala Ser Ser Pro Pro Pro Pro Arg Ala Leu Gln Ala 
            660                 665                 670         


Glu Ser Arg Gln Leu Val Asp Leu Tyr Lys Val Leu Glu Ser Arg Gly 
        675                 680                 685             


Ser Asp Pro Lys Pro Glu Asn Pro Ala Cys Pro Trp Thr Val Leu Pro 
    690                 695                 700                 


Ala Gly Asp Leu Pro Thr His Asp Gly Tyr Leu Pro Ser Asn Ile Asp 
705                 710                 715                 720 


Asp Leu Pro Ser His Glu Ala Pro Leu Ala Asp Ser Leu Glu Glu Leu 
                725                 730                 735     


Glu Pro Gln His Ile Ser Leu Ser Val Phe Pro Ser Ser Ser Leu His 
            740                 745                 750         


Pro Leu Thr Phe Ser Cys Gly Asp Lys Leu Thr Leu Asp Gln Leu Lys 
        755                 760                 765             


Met Arg Cys Asp Ser Leu Met Leu 
    770                 775     


<210>  110
<211>  370
<212>  PRT
<213>  Homo sapiens

<400>  110

Met Leu Pro Arg Arg Leu Leu Ala Ala Trp Leu Ala Gly Thr Arg Gly 
1               5                   10                  15      


Gly Gly Leu Leu Ala Leu Leu Ala Asn Gln Cys Arg Phe Val Thr Gly 
            20                  25                  30          


Leu Arg Val Arg Arg Ala Gln Gln Ile Ala Gln Leu Tyr Gly Arg Leu 
        35                  40                  45              


Tyr Ser Glu Ser Ser Arg Arg Val Leu Leu Gly Arg Leu Trp Arg Arg 
    50                  55                  60                  


Leu His Gly Arg Pro Gly His Ala Ser Ala Leu Met Ala Ala Leu Ala 
65                  70                  75                  80  


Gly Val Phe Val Trp Asp Glu Glu Arg Ile Gln Glu Glu Glu Leu Gln 
                85                  90                  95      


Arg Ser Ile Asn Glu Met Lys Arg Leu Glu Glu Met Ser Asn Met Phe 
            100                 105                 110         


Gln Ser Ser Gly Val Gln His His Pro Pro Glu Pro Lys Ala Gln Thr 
        115                 120                 125             


Glu Gly Asn Glu Asp Ser Glu Gly Lys Glu Gln Arg Trp Glu Met Val 
    130                 135                 140                 


Met Asp Lys Lys His Phe Lys Leu Trp Arg Arg Pro Ile Thr Gly Thr 
145                 150                 155                 160 


His Leu Tyr Gln Tyr Arg Val Phe Gly Thr Tyr Thr Asp Val Thr Pro 
                165                 170                 175     


Arg Gln Phe Phe Asn Val Gln Leu Asp Thr Glu Tyr Arg Lys Lys Trp 
            180                 185                 190         


Asp Ala Leu Val Ile Lys Leu Glu Val Ile Glu Arg Asp Val Val Ser 
        195                 200                 205             


Gly Ser Glu Val Leu His Trp Val Thr His Phe Pro Tyr Pro Met Tyr 
    210                 215                 220                 


Ser Arg Asp Tyr Val Tyr Val Arg Arg Tyr Ser Val Asp Gln Glu Asn 
225                 230                 235                 240 


Asn Met Met Val Leu Val Ser Arg Ala Val Glu His Pro Ser Val Pro 
                245                 250                 255     


Glu Ser Pro Glu Phe Val Arg Val Arg Ser Tyr Glu Ser Gln Met Val 
            260                 265                 270         


Ile Arg Pro His Lys Ser Phe Asp Glu Asn Gly Phe Asp Tyr Leu Leu 
        275                 280                 285             


Thr Tyr Ser Asp Asn Pro Gln Thr Val Phe Pro Arg Tyr Cys Val Ser 
    290                 295                 300                 


Trp Met Val Ser Ser Gly Met Pro Asp Phe Leu Glu Lys Leu His Met 
305                 310                 315                 320 


Ala Thr Leu Lys Ala Lys Asn Met Glu Ile Lys Val Lys Asp Tyr Ile 
                325                 330                 335     


Ser Ala Lys Pro Leu Glu Met Ser Ser Glu Ala Lys Ala Thr Ser Gln 
            340                 345                 350         


Ser Ser Glu Arg Lys Asn Glu Gly Ser Cys Gly Pro Ala Arg Ile Glu 
        355                 360                 365             


Tyr Ala 
    370 


<210>  111
<211>  154
<212>  PRT
<213>  Homo sapiens

<400>  111

Met Val Ser Lys Ala Lys Val Ile Val Asn Gly Trp Leu Phe Pro Ala 
1               5                   10                  15      


Cys Leu Gly Phe Cys Leu Ser Glu Ser Phe Phe Met Val Lys Gly Ala 
            20                  25                  30          


Ala Leu Phe Leu Gln Gln Gly Ser Ser Pro Gln Gly Gln Arg Ser Leu 
        35                  40                  45              


Gln His Pro His Lys His Ala Gly Asp Leu Pro Gln His Leu Gln Val 
    50                  55                  60                  


Met Ile Asn Leu Leu Arg Cys Glu Asp Arg Ile Lys Leu Ala Val Arg 
65                  70                  75                  80  


Leu Glu Ser Ala Trp Ala Asp Arg Val Arg Tyr Met Val Val Val Tyr 
                85                  90                  95      


Ser Ser Gly Arg Gln Asp Thr Glu Glu Asn Ile Leu Leu Gly Val Asp 
            100                 105                 110         


Phe Ser Ser Lys Glu Ser Lys Ser Cys Thr Ile Gly Met Val Leu Arg 
        115                 120                 125             


Leu Trp Ser Asp Thr Lys Ile His Leu Asp Gly Asp Gly Gly Phe Ser 
    130                 135                 140                 


Val Ser Thr Ala Gly Arg Met His Ile Phe 
145                 150                 


<210>  112
<211>  37
<212>  PRT
<213>  Homo sapiens

<400>  112

Met Ala Leu Val Thr Leu Gln Arg Ser Pro Thr Pro Ser Ala Ala Ser 
1               5                   10                  15      


Ser Ser Ala Ser Asn Ser Glu Leu Glu Ala Gly Ser Glu Glu Asp Arg 
            20                  25                  30          


Lys Leu Asn Leu Arg 
        35          


<210>  113
<211>  147
<212>  PRT
<213>  Homo sapiens

<400>  113

Met Ala Gly Asn Ser Ile Leu Leu Ala Ala Val Ser Ile Leu Ser Ala 
1               5                   10                  15      


Cys Gln Gln Ser Tyr Phe Ala Leu Gln Val Gly Lys Ala Arg Leu Lys 
            20                  25                  30          


Tyr Lys Val Thr Pro Pro Ala Val Thr Gly Ser Pro Glu Phe Glu Arg 
        35                  40                  45              


Val Phe Arg Ala Gln Gln Asn Cys Val Glu Phe Tyr Pro Ile Phe Ile 
    50                  55                  60                  


Ile Thr Leu Trp Met Ala Gly Trp Tyr Phe Asn Gln Val Phe Ala Thr 
65                  70                  75                  80  


Cys Leu Gly Leu Val Tyr Ile Tyr Gly Arg His Leu Tyr Phe Trp Gly 
                85                  90                  95      


Tyr Ser Glu Ala Ala Lys Lys Arg Ile Thr Gly Phe Arg Leu Ser Leu 
            100                 105                 110         


Gly Ile Leu Ala Leu Leu Thr Leu Leu Gly Ala Leu Gly Ile Ala Asn 
        115                 120                 125             


Ser Phe Leu Asp Glu Tyr Leu Asp Leu Asn Ile Ala Lys Lys Leu Arg 
    130                 135                 140                 


Arg Gln Phe 
145         


<210>  114
<211>  147
<212>  PRT
<213>  Homo sapiens

<400>  114

Met Ala Gly Asn Ser Ile Leu Leu Ala Ala Val Ser Ile Leu Ser Ala 
1               5                   10                  15      


Cys Gln Gln Ser Tyr Phe Ala Leu Gln Val Gly Lys Ala Arg Leu Lys 
            20                  25                  30          


Tyr Lys Val Thr Pro Pro Ala Val Thr Gly Ser Pro Glu Phe Glu Arg 
        35                  40                  45              


Val Phe Arg Ala Gln Gln Asn Cys Val Glu Phe Tyr Pro Ile Phe Ile 
    50                  55                  60                  


Ile Thr Leu Trp Met Ala Gly Trp Tyr Phe Asn Gln Val Phe Ala Thr 
65                  70                  75                  80  


Cys Leu Gly Leu Val Tyr Ile Tyr Gly Arg His Leu Tyr Phe Trp Gly 
                85                  90                  95      


Tyr Ser Glu Ala Ala Lys Lys Arg Ile Thr Gly Phe Arg Leu Ser Leu 
            100                 105                 110         


Gly Ile Leu Ala Leu Leu Thr Leu Leu Gly Ala Leu Gly Ile Ala Asn 
        115                 120                 125             


Ser Phe Leu Asp Glu Tyr Leu Asp Leu Asn Ile Ala Lys Lys Leu Arg 
    130                 135                 140                 


Arg Gln Phe 
145         


<210>  115
<211>  77
<212>  PRT
<213>  Homo sapiens

<400>  115

Met Ala Gly Asn Ser Ile Leu Leu Ala Ala Val Ser Ile Leu Ser Ala 
1               5                   10                  15      


Cys Gln Gln Ser Tyr Phe Ala Leu Gln Val Gly Lys Ala Arg Leu Lys 
            20                  25                  30          


Tyr Lys Val Thr Pro Pro Ala Val Thr Gly Ser Pro Glu Phe Glu Arg 
        35                  40                  45              


Val Phe Arg Ala His Phe Cys Tyr Leu Ser Gly Ser Gly Val His Ile 
    50                  55                  60                  


Trp Pro Ser Pro Ile Leu Leu Gly Ile Phe Arg Ser Cys 
65                  70                  75          


<210>  116
<211>  147
<212>  PRT
<213>  Homo sapiens

<400>  116

Met Ala Gly Asn Ser Ile Leu Leu Ala Ala Val Ser Ile Leu Ser Ala 
1               5                   10                  15      


Cys Gln Gln Ser Tyr Phe Ala Leu Gln Val Gly Lys Ala Arg Leu Lys 
            20                  25                  30          


Tyr Lys Val Thr Pro Pro Ala Val Thr Gly Ser Pro Glu Phe Glu Arg 
        35                  40                  45              


Val Phe Arg Ala Gln Gln Asn Cys Val Glu Phe Tyr Pro Ile Phe Ile 
    50                  55                  60                  


Ile Thr Leu Trp Met Ala Gly Trp Tyr Phe Asn Gln Val Phe Ala Thr 
65                  70                  75                  80  


Cys Leu Gly Leu Val Tyr Ile Tyr Gly Arg His Leu Tyr Phe Trp Gly 
                85                  90                  95      


Tyr Ser Glu Ala Ala Lys Lys Arg Ile Thr Gly Phe Arg Leu Ser Leu 
            100                 105                 110         


Gly Ile Leu Ala Leu Leu Thr Leu Leu Gly Ala Leu Gly Ile Ala Asn 
        115                 120                 125             


Ser Phe Leu Asp Glu Tyr Leu Asp Leu Asn Ile Ala Lys Lys Leu Arg 
    130                 135                 140                 


Arg Gln Phe 
145         


<210>  117
<211>  110
<212>  PRT
<213>  Homo sapiens

<400>  117

Met Phe Lys Ser Pro Leu Lys Val Pro Ala Leu Ile Gln Cys Leu Gly 
1               5                   10                  15      


Met Tyr Asp Ser Ser Leu Ala Ala Lys Tyr Leu Leu His Ser Leu Val 
            20                  25                  30          


Phe Gly Ser Ala Val Tyr Ser Ser Gly Ser Glu Arg His Leu Thr Tyr 
        35                  40                  45              


Ile Gln Lys Ile Phe Arg Met Glu Ile Phe Gly Cys Phe Ala Leu Thr 
    50                  55                  60                  


Glu Leu Ser His Gly Ser Asn Thr Lys Ala Ile Arg Thr Thr Ala His 
65                  70                  75                  80  


Tyr Asp Pro Ala Thr Glu Glu Phe Ile Ile His Ser Pro Asp Phe Glu 
                85                  90                  95      


Ala Ala Lys Phe Trp Val Gly Asn Met Gly Lys Thr Ala Thr 
            100                 105                 110 


<210>  118
<211>  121
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  118

Xaa Gly His Gln Asn Val Phe Pro Asn His Ile Ser Val Gly Thr Asn 
1               5                   10                  15      


Arg Lys Arg Cys Leu Glu Asp Ser Glu Asp Phe Gly Val Lys Lys Ala 
            20                  25                  30          


Arg Thr Glu Ala Gln Ser Leu Asp Ser Ala Val Pro Leu Thr Asn Gly 
        35                  40                  45              


Asp Thr Glu Asp Asp Ala Asp Lys Met His Val Asp Arg Glu Phe Ala 
    50                  55                  60                  


Val Val Thr Gly Gly Ser Gly Gln Phe Pro Val Ser Cys Asn Asn Asn 
65                  70                  75                  80  


Pro Met Val Glu Asp Thr Lys Gln Gln Glu Ser Gly Ser Val Gly Pro 
                85                  90                  95      


Lys Glu Ile Glu Ile Tyr Thr Val Ser Ala Met Gln Thr Pro Cys Arg 
            100                 105                 110         


Cys Arg Asn Gln Tyr Ala Tyr Tyr Phe 
        115                 120     


<210>  119
<211>  37
<212>  PRT
<213>  Homo sapiens

<400>  119

Met Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe 
1               5                   10                  15      


Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Gly Asp Cys 
            20                  25                  30          


Ile Leu Val Asn Glu 
        35          


<210>  120
<211>  129
<212>  PRT
<213>  Homo sapiens

<400>  120

Met Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe 
1               5                   10                  15      


Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Glu 
            20                  25                  30          


Asp Gly Lys Lys Phe Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys 
        35                  40                  45              


Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val 
    50                  55                  60                  


Ala Gln Val Cys Ser Leu Ile Cys Phe Val Leu Leu Ser Ser Ile Tyr 
65                  70                  75                  80  


Leu Leu Tyr Phe Phe Ile Gly Gly Ile Phe Ile Arg Phe Lys Asn Lys 
                85                  90                  95      


Lys Ser Glu Lys Ser His Pro His Ala Ile Pro Ser Asp Gln Tyr Pro 
            100                 105                 110         


His Lys Lys Leu Leu Leu Leu Met Phe Leu Val Leu Trp Phe Lys His 
        115                 120                 125             


Ile 
    


<210>  121
<211>  97
<212>  PRT
<213>  Homo sapiens

<400>  121

Met Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe 
1               5                   10                  15      


Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Asp Glu Cys Gly 
            20                  25                  30          


Ser Glu Ser Gln Thr Asp Tyr Ile Ser Arg Leu Cys Leu Trp Cys His 
        35                  40                  45              


Trp Ala Pro Arg His His Pro Thr Thr Cys His Ser Arg Leu Arg Cys 
    50                  55                  60                  


Gly Ala Ser Lys Thr Gly Met Thr Gly Met Ala Ser Ser Leu Ser Ser 
65                  70                  75                  80  


Leu Phe Leu Asp Leu Pro Trp Arg Asp Leu Val Pro Pro Asp Met Cys 
                85                  90                  95      


Thr 
    


<210>  122
<211>  276
<212>  PRT
<213>  Homo sapiens

<400>  122

Met Pro Val Pro Ala Ser Trp Pro His Pro Pro Gly Pro Phe Leu Leu 
1               5                   10                  15      


Leu Thr Leu Leu Leu Gly Leu Thr Glu Val Ala Gly Glu Glu Glu Leu 
            20                  25                  30          


Gln Met Ile Gln Pro Glu Lys Leu Leu Leu Val Thr Val Gly Lys Thr 
        35                  40                  45              


Ala Thr Leu His Cys Thr Val Thr Ser Leu Leu Pro Val Gly Pro Val 
    50                  55                  60                  


Leu Trp Phe Arg Gly Val Gly Pro Gly Arg Glu Leu Ile Tyr Asn Gln 
65                  70                  75                  80  


Lys Glu Gly His Phe Pro Arg Val Thr Thr Val Ser Asp Leu Thr Lys 
                85                  90                  95      


Arg Asn Asn Met Asp Phe Ser Ile Arg Ile Ser Ser Ile Thr Pro Ala 
            100                 105                 110         


Asp Val Gly Thr Tyr Tyr Cys Val Lys Phe Arg Lys Gly Ser Pro Glu 
        115                 120                 125             


Asn Val Glu Phe Lys Ser Gly Pro Gly Thr Glu Met Ala Leu Gly Ala 
    130                 135                 140                 


Lys Pro Ser Ala Pro Val Val Leu Gly Pro Ala Ala Arg Thr Thr Pro 
145                 150                 155                 160 


Glu His Thr Val Ser Phe Thr Cys Glu Ser His Gly Phe Ser Pro Arg 
                165                 170                 175     


Asp Ile Thr Leu Lys Trp Phe Lys Asn Gly Asn Glu Leu Ser Asp Phe 
            180                 185                 190         


Gln Thr Asn Val Asp Pro Thr Gly Gln Ser Val Ala Tyr Ser Ile Arg 
        195                 200                 205             


Ser Thr Ala Arg Val Val Leu Asp Pro Trp Asp Val Arg Ser Gln Val 
    210                 215                 220                 


Ile Cys Glu Val Ala His Val Thr Leu Gln Gly Asp Pro Leu Arg Gly 
225                 230                 235                 240 


Thr Ala Asn Leu Ser Glu Ala Ile Arg Gly Pro Ala Ser Ser Leu Thr 
                245                 250                 255     


Ala Leu Leu Leu Ile Ala Val Leu Leu Gly Pro Ile Tyr Val Pro Trp 
            260                 265                 270         


Lys Gln Lys Thr 
        275     


<210>  123
<211>  387
<212>  PRT
<213>  Homo sapiens

<400>  123

Met Pro Val Pro Ala Ser Trp Pro His Pro Pro Gly Pro Phe Leu Leu 
1               5                   10                  15      


Leu Thr Leu Leu Leu Gly Leu Thr Glu Val Ala Gly Glu Glu Glu Leu 
            20                  25                  30          


Gln Met Ile Gln Pro Glu Lys Leu Leu Leu Val Thr Val Gly Lys Thr 
        35                  40                  45              


Ala Thr Leu His Cys Thr Val Thr Ser Leu Leu Pro Val Gly Pro Val 
    50                  55                  60                  


Leu Trp Phe Arg Gly Val Gly Pro Gly Arg Glu Leu Ile Tyr Asn Gln 
65                  70                  75                  80  


Lys Glu Gly His Phe Pro Arg Val Thr Thr Val Ser Asp Leu Thr Lys 
                85                  90                  95      


Arg Asn Asn Met Asp Phe Ser Ile Arg Ile Ser Ser Ile Thr Pro Ala 
            100                 105                 110         


Asp Val Gly Thr Tyr Tyr Cys Val Lys Phe Arg Lys Gly Ser Pro Glu 
        115                 120                 125             


Asn Val Glu Phe Lys Ser Gly Pro Gly Thr Glu Met Ala Leu Gly Ala 
    130                 135                 140                 


Lys Pro Ser Ala Pro Val Val Leu Gly Pro Ala Ala Arg Thr Thr Pro 
145                 150                 155                 160 


Glu His Thr Val Ser Phe Thr Cys Glu Ser His Gly Phe Ser Pro Arg 
                165                 170                 175     


Asp Ile Thr Leu Lys Trp Phe Lys Asn Gly Asn Glu Leu Ser Asp Phe 
            180                 185                 190         


Gln Thr Asn Val Asp Pro Thr Gly Gln Ser Val Ala Tyr Ser Ile Arg 
        195                 200                 205             


Ser Thr Ala Arg Val Val Leu Asp Pro Trp Asp Val Arg Ser Gln Val 
    210                 215                 220                 


Ile Cys Glu Val Ala His Val Thr Leu Gln Gly Asp Pro Leu Arg Gly 
225                 230                 235                 240 


Thr Ala Asn Leu Ser Glu Ala Ile Arg Val Pro Pro Thr Leu Glu Val 
                245                 250                 255     


Thr Gln Gln Pro Met Arg Val Gly Asn Gln Val Asn Val Thr Cys Gln 
            260                 265                 270         


Val Arg Lys Phe Tyr Pro Gln Ser Leu Gln Leu Thr Trp Ser Glu Asn 
        275                 280                 285             


Gly Asn Val Cys Gln Arg Glu Thr Ala Ser Thr Leu Thr Glu Asn Lys 
    290                 295                 300                 


Asp Gly Thr Tyr Asn Trp Thr Ser Trp Phe Leu Val Asn Ile Ser Asp 
305                 310                 315                 320 


Gln Arg Asp Asp Val Val Leu Thr Cys Gln Val Lys His Asp Gly Gln 
                325                 330                 335     


Leu Ala Val Ser Lys Arg Leu Ala Leu Glu Val Thr Val His Gln Lys 
            340                 345                 350         


Asp Gln Ser Ser Asp Ala Thr Pro Gly Pro Ala Ser Ser Leu Thr Ala 
        355                 360                 365             


Leu Leu Leu Ile Ala Val Leu Leu Gly Pro Ile Tyr Val Pro Trp Lys 
    370                 375                 380                 


Gln Lys Thr 
385         


<210>  124
<211>  170
<212>  PRT
<213>  Homo sapiens

<400>  124

Met Pro Val Pro Ala Ser Trp Pro His Pro Pro Gly Pro Phe Leu Leu 
1               5                   10                  15      


Leu Thr Leu Leu Leu Gly Leu Thr Glu Val Ala Gly Glu Glu Glu Leu 
            20                  25                  30          


Gln Met Ile Gln Pro Glu Lys Leu Leu Leu Val Thr Val Gly Lys Thr 
        35                  40                  45              


Ala Thr Leu His Cys Thr Val Thr Ser Leu Leu Pro Val Gly Pro Val 
    50                  55                  60                  


Leu Trp Phe Arg Gly Val Gly Pro Gly Arg Glu Leu Ile Tyr Asn Gln 
65                  70                  75                  80  


Lys Glu Gly His Phe Pro Arg Val Thr Thr Val Ser Asp Leu Thr Lys 
                85                  90                  95      


Arg Asn Asn Met Asp Phe Ser Ile Arg Ile Ser Ser Ile Thr Pro Ala 
            100                 105                 110         


Asp Val Gly Thr Tyr Tyr Cys Val Lys Phe Arg Lys Gly Ser Pro Glu 
        115                 120                 125             


Asn Val Glu Phe Lys Ser Gly Pro Gly Thr Glu Met Ala Leu Gly Gly 
    130                 135                 140                 


Pro Ala Ser Ser Leu Thr Ala Leu Leu Leu Ile Ala Val Leu Leu Gly 
145                 150                 155                 160 


Pro Ile Tyr Val Pro Trp Lys Gln Lys Thr 
                165                 170 


<210>  125
<211>  354
<212>  PRT
<213>  Homo sapiens

<400>  125

Met Ile Gln Pro Glu Lys Leu Leu Leu Val Thr Val Gly Lys Thr Ala 
1               5                   10                  15      


Thr Leu His Cys Thr Val Thr Ser Leu Leu Pro Val Gly Pro Val Leu 
            20                  25                  30          


Trp Phe Arg Gly Val Gly Pro Gly Arg Glu Leu Ile Tyr Asn Gln Lys 
        35                  40                  45              


Glu Gly His Phe Pro Arg Val Thr Thr Val Ser Asp Leu Thr Lys Arg 
    50                  55                  60                  


Asn Asn Met Asp Phe Ser Ile Arg Ile Ser Ser Ile Thr Pro Ala Asp 
65                  70                  75                  80  


Val Gly Thr Tyr Tyr Cys Val Lys Phe Arg Lys Gly Ser Pro Glu Asn 
                85                  90                  95      


Val Glu Phe Lys Ser Gly Pro Gly Thr Glu Met Ala Leu Gly Ala Lys 
            100                 105                 110         


Pro Ser Ala Pro Val Val Leu Gly Pro Ala Ala Arg Thr Thr Pro Glu 
        115                 120                 125             


His Thr Val Ser Phe Thr Cys Glu Ser His Gly Phe Ser Pro Arg Asp 
    130                 135                 140                 


Ile Thr Leu Lys Trp Phe Lys Asn Gly Asn Glu Leu Ser Asp Phe Gln 
145                 150                 155                 160 


Thr Asn Val Asp Pro Thr Gly Gln Ser Val Ala Tyr Ser Ile Arg Ser 
                165                 170                 175     


Thr Ala Arg Val Val Leu Asp Pro Trp Asp Val Arg Ser Gln Val Ile 
            180                 185                 190         


Cys Glu Val Ala His Val Thr Leu Gln Gly Asp Pro Leu Arg Gly Thr 
        195                 200                 205             


Ala Asn Leu Ser Glu Ala Ile Arg Val Pro Pro Thr Leu Glu Val Thr 
    210                 215                 220                 


Gln Gln Pro Met Arg Val Gly Asn Gln Val Asn Val Thr Cys Gln Val 
225                 230                 235                 240 


Arg Lys Phe Tyr Pro Gln Ser Leu Gln Leu Thr Trp Ser Glu Asn Gly 
                245                 250                 255     


Asn Val Cys Gln Arg Glu Thr Ala Ser Thr Leu Thr Glu Asn Lys Asp 
            260                 265                 270         


Gly Thr Tyr Asn Trp Thr Ser Trp Phe Leu Val Asn Ile Ser Asp Gln 
        275                 280                 285             


Arg Asp Asp Val Val Leu Thr Cys Gln Val Lys His Asp Gly Gln Leu 
    290                 295                 300                 


Ala Val Ser Lys Arg Leu Ala Leu Glu Val Thr Val His Gln Lys Asp 
305                 310                 315                 320 


Gln Ser Ser Asp Ala Thr Pro Gly Pro Ala Ser Ser Leu Thr Ala Leu 
                325                 330                 335     


Leu Leu Ile Ala Val Leu Leu Gly Pro Ile Tyr Val Pro Trp Lys Gln 
            340                 345                 350         


Lys Thr 
        


<210>  126
<211>  276
<212>  PRT
<213>  Homo sapiens

<400>  126

Met Pro Val Pro Ala Ser Trp Pro His Pro Pro Gly Pro Phe Leu Leu 
1               5                   10                  15      


Leu Thr Leu Leu Leu Gly Leu Thr Glu Val Ala Gly Glu Glu Glu Leu 
            20                  25                  30          


Gln Met Ile Gln Pro Glu Lys Leu Leu Leu Val Thr Val Gly Lys Thr 
        35                  40                  45              


Ala Thr Leu His Cys Thr Val Thr Ser Leu Leu Pro Val Gly Pro Val 
    50                  55                  60                  


Leu Trp Phe Arg Gly Val Gly Pro Gly Arg Glu Leu Ile Tyr Asn Gln 
65                  70                  75                  80  


Lys Glu Gly His Phe Pro Arg Val Thr Thr Val Ser Asp Leu Thr Lys 
                85                  90                  95      


Arg Asn Asn Met Asp Phe Ser Ile Arg Ile Ser Ser Ile Thr Pro Ala 
            100                 105                 110         


Asp Val Gly Thr Tyr Tyr Cys Val Lys Phe Arg Lys Gly Ser Pro Glu 
        115                 120                 125             


Asn Val Glu Phe Lys Ser Gly Pro Gly Thr Glu Met Ala Leu Gly Ala 
    130                 135                 140                 


Lys Pro Ser Ala Pro Val Val Leu Gly Pro Ala Ala Arg Thr Thr Pro 
145                 150                 155                 160 


Glu His Thr Val Ser Phe Thr Cys Glu Ser His Gly Phe Ser Pro Arg 
                165                 170                 175     


Asp Ile Thr Leu Lys Trp Phe Lys Asn Gly Asn Glu Leu Ser Asp Phe 
            180                 185                 190         


Gln Thr Asn Val Asp Pro Thr Gly Gln Ser Val Ala Tyr Ser Ile Arg 
        195                 200                 205             


Ser Thr Ala Arg Val Val Leu Asp Pro Trp Asp Val Arg Ser Gln Val 
    210                 215                 220                 


Ile Cys Glu Val Ala His Val Thr Leu Gln Gly Asp Pro Leu Arg Gly 
225                 230                 235                 240 


Thr Ala Asn Leu Ser Glu Ala Ile Arg Gly Pro Ala Ser Ser Leu Thr 
                245                 250                 255     


Ala Leu Leu Leu Ile Ala Val Leu Leu Gly Pro Ile Tyr Val Pro Trp 
            260                 265                 270         


Lys Gln Lys Thr 
        275     


<210>  127
<211>  556
<212>  PRT
<213>  Homo sapiens

<400>  127

Met His Gly Ser Leu Glu Ala Leu Leu Phe Leu Pro Gln Val Thr Leu 
1               5                   10                  15      


Ser Leu Ala His Ala His Leu Ile Cys Ser Asn Ala Gln Leu Glu Met 
            20                  25                  30          


Cys Val Phe Pro His Arg Phe Leu Gly Asp Leu Thr Thr Glu Gly Ile 
        35                  40                  45              


Asn Lys Pro Gly Phe Tyr Lys Gly Pro Ala Gly Ser Gln Val Thr Leu 
    50                  55                  60                  


Ser Ser Leu Gly Asn Gln Thr Arg Val Leu Leu Glu Glu Gln Ala Arg 
65                  70                  75                  80  


His Leu Leu Asn Glu Gln Glu His Ala Thr Met Ala Tyr Tyr Leu Asp 
                85                  90                  95      


Glu Tyr Arg Gly Gly Ser Val Ser Val Glu Ala Leu Val Met Ala Leu 
            100                 105                 110         


Phe Lys Leu Leu Asn Thr His Ala Lys Phe Ser Leu Leu Ser Glu Val 
        115                 120                 125             


Arg Gly Thr Ile Ser Pro Gln Asp Leu Glu Arg Phe Asp His Leu Val 
    130                 135                 140                 


Leu Arg Arg Glu Ile Glu Ser Met Lys Ala Arg Gln Pro Pro Gly Pro 
145                 150                 155                 160 


Gly Ala Gly Asp Thr Tyr Ser Met Val Ser Tyr Ser Asp Thr Gly Ser 
                165                 170                 175     


Ser Thr Gly Ser His Gly Thr Ser Thr Thr Val Ser Ser Ala Arg Asn 
            180                 185                 190         


Thr Leu Asp Leu Glu Glu Thr Gly Glu Ala Val Gln Gly Asn Ile Asn 
        195                 200                 205             


Ala Leu Pro Asp Val Ser Val Asp Asp Val Arg Ser Thr Ser Gln Gly 
    210                 215                 220                 


Leu Ser Ser Phe Lys Pro Leu Pro Arg Pro Pro Pro Leu Ala Gln Gly 
225                 230                 235                 240 


Asn Asp Leu Pro Leu Gly Gln Pro Arg Lys Leu Gly Arg Glu Asp Leu 
                245                 250                 255     


Gln Pro Pro Ser Ser Met Pro Ser Cys Ser Gly Thr Val Phe Ser Ala 
            260                 265                 270         


Pro Gln Asn Arg Ser Pro Pro Ala Gly Thr Ala Pro Thr Pro Gly Thr 
        275                 280                 285             


Ser Ser Ala Gln Asp Leu Pro Ser Ser Pro Ile Tyr Ala Ser Val Ser 
    290                 295                 300                 


Pro Ala Asn Pro Ser Ser Lys Arg Pro Leu Asp Ala His Leu Ala Leu 
305                 310                 315                 320 


Val Asn Gln His Pro Ile Gly Pro Phe Pro Arg Val Gln Ser Pro Pro 
                325                 330                 335     


His Leu Lys Ser Pro Ser Ala Glu Ala Thr Val Ala Gly Gly Cys Leu 
            340                 345                 350         


Leu Pro Pro Ser Pro Ser Gly His Pro Asp Gln Thr Gly Thr Asn Gln 
        355                 360                 365             


His Phe Val Met Val Glu Val His Arg Pro Asp Ser Glu Pro Asp Val 
    370                 375                 380                 


Asn Glu Val Arg Ala Leu Pro Gln Thr Arg Thr Ala Ser Thr Leu Ser 
385                 390                 395                 400 


Gln Leu Ser Asp Ser Gly Gln Thr Leu Ser Glu Asp Ser Gly Val Asp 
                405                 410                 415     


Ala Gly Glu Ala Glu Ala Ser Ala Pro Gly Arg Gly Arg Gln Ser Val 
            420                 425                 430         


Ser Thr Lys Ser Arg Ser Ser Lys Glu Leu Pro Arg Asn Glu Arg Pro 
        435                 440                 445             


Thr Asp Gly Ala Asn Lys Pro Pro Gly Leu Leu Glu Pro Thr Ser Thr 
    450                 455                 460                 


Leu Val Arg Val Lys Lys Ser Ala Ala Thr Leu Gly Ile Ala Ile Glu 
465                 470                 475                 480 


Gly Gly Ala Asn Thr Arg Gln Pro Leu Pro Arg Ile Val Thr Ile Gln 
                485                 490                 495     


Arg Gly Gly Ser Ala His Asn Cys Gly Gln Leu Lys Val Gly His Val 
            500                 505                 510         


Ile Leu Glu Val Asn Gly Leu Thr Leu Arg Gly Lys Glu His Arg Glu 
        515                 520                 525             


Ala Ala Arg Ile Ile Ala Glu Ala Phe Lys Thr Lys Asp Arg Asp Tyr 
    530                 535                 540                 


Ile Asp Phe Leu Val Thr Glu Phe Asn Val Met Leu 
545                 550                 555     


<210>  128
<211>  180
<212>  PRT
<213>  Homo sapiens

<400>  128

Met Ser Val Leu Arg Pro Leu Asp Lys Leu Pro Gly Leu Asn Thr Ala 
1               5                   10                  15      


Thr Ile Leu Leu Val Gly Thr Glu Asp Ala Leu Leu Gln Gln Leu Ala 
            20                  25                  30          


Asp Ser Met Leu Lys Glu Asp Cys Ala Ser Glu Leu Lys Val His Leu 
        35                  40                  45              


Ala Lys Ser Leu Pro Leu Pro Ser Ser Val Asn Arg Pro Arg Ile Asp 
    50                  55                  60                  


Leu Ile Val Phe Val Val Asn Leu His Ser Lys Tyr Ser Leu Gln Asn 
65                  70                  75                  80  


Thr Glu Glu Ser Leu Arg His Val Asp Ala Ser Phe Phe Leu Gly Lys 
                85                  90                  95      


Val Cys Phe Leu Ala Thr Gly Ala Gly Arg Glu Ser His Cys Ser Ile 
            100                 105                 110         


His Arg His Thr Val Val Lys Leu Ala His Thr Tyr Gln Ser Pro Leu 
        115                 120                 125             


Leu Tyr Cys Asp Leu Glu Val Glu Gly Phe Arg Ala Thr Met Ala Gln 
    130                 135                 140                 


Arg Leu Val Arg Val Leu Gln Ile Cys Ala Gly His Val Pro Gly Val 
145                 150                 155                 160 


Ser Ala Leu Asn Leu Leu Ser Leu Leu Arg Ser Ser Glu Gly Pro Ser 
                165                 170                 175     


Leu Glu Asp Leu 
            180 


<210>  129
<211>  146
<212>  PRT
<213>  Homo sapiens

<400>  129

Met Leu Lys Glu Asp Cys Ala Ser Glu Leu Lys Val His Leu Ala Lys 
1               5                   10                  15      


Ser Leu Pro Leu Pro Ser Ser Val Asn Arg Pro Arg Ile Asp Leu Ile 
            20                  25                  30          


Val Phe Val Val Asn Leu His Ser Lys Tyr Ser Leu Gln Asn Thr Glu 
        35                  40                  45              


Glu Ser Leu Arg His Val Asp Ala Ser Phe Phe Leu Gly Lys Val Cys 
    50                  55                  60                  


Phe Leu Ala Thr Gly Ala Gly Arg Glu Ser His Cys Ser Ile His Arg 
65                  70                  75                  80  


His Thr Val Val Lys Leu Ala His Thr Tyr Gln Ser Pro Leu Leu Tyr 
                85                  90                  95      


Cys Asp Leu Glu Val Glu Gly Phe Arg Ala Thr Met Ala Gln Arg Leu 
            100                 105                 110         


Val Arg Val Leu Gln Ile Cys Ala Gly His Val Pro Gly Val Ser Ala 
        115                 120                 125             


Leu Asn Leu Leu Ser Leu Leu Arg Ser Ser Glu Gly Pro Ser Leu Glu 
    130                 135                 140                 


Asp Leu 
145     


<210>  130
<211>  125
<212>  PRT
<213>  Homo sapiens

<400>  130

Met Leu Lys Glu Asp Cys Ala Ser Glu Leu Lys Val His Leu Ala Lys 
1               5                   10                  15      


Ser Leu Pro Leu Pro Ser Ser Val Asn Arg Pro Arg Ile Asp Leu Ile 
            20                  25                  30          


Val Phe Val Val Asn Leu His Ser Lys Tyr Arg Ile Arg Glu Ala Arg 
        35                  40                  45              


Thr Ser Ala Phe Ser Val Val Lys Phe Cys Ser Leu Val Cys Phe Leu 
    50                  55                  60                  


Thr Leu Ala Trp Pro Pro Gln Ser Pro Glu His Arg Gly Val Pro Ala 
65                  70                  75                  80  


Pro Cys Gly Cys Gln Leu Leu Leu Gly Glu Gly Val Phe Pro Arg His 
                85                  90                  95      


Arg Cys Trp Ala Gly Glu Pro Leu Gln His Ser Pro Ala His Arg Gly 
            100                 105                 110         


Glu Ala Gly Pro His Leu Ser Lys Pro Pro Ala Leu Leu 
        115                 120                 125 


<210>  131
<211>  73
<212>  PRT
<213>  Homo sapiens

<400>  131

Met Leu Lys Glu Asp Cys Ala Ser Glu Leu Lys Val His Leu Ala Lys 
1               5                   10                  15      


Ser Leu Pro Leu Pro Ser Ser Val Asn Arg Pro Arg Ile Asp Leu Ile 
            20                  25                  30          


Val Phe Val Val Asn Leu His Ser Lys Tyr Ser Leu Gln Asn Thr Glu 
        35                  40                  45              


Glu Ser Leu Arg His Val Asp Ala Ser Phe Phe Leu Gly Lys Val Cys 
    50                  55                  60                  


Phe Leu Ala Thr Gly Gly Gly Arg Leu 
65                  70              


<210>  132
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  132

Met Ser Val Leu Arg Pro Leu Asp Lys Leu Pro Gly Leu Asn Thr Ala 
1               5                   10                  15      


Thr Ile Leu Leu Val Gly Thr Glu Asp Ala Leu Leu Gln Gln Leu Ala 
            20                  25                  30          


Asp Ser Met Leu Lys Glu Asp Cys Ala Ser Glu Leu Lys Val His Leu 
        35                  40                  45              


Ala Lys Ser Leu Pro Leu Pro Ser Ser Val Asn Arg Pro Arg Ile Asp 
    50                  55                  60                  


Leu Ile Val Phe Val Val Asn Leu His Ser Lys Tyr Ser Leu Gln Asn 
65                  70                  75                  80  


Thr Glu Glu Ser Leu Arg His Val Asp Ala Ser Phe Phe Leu Gly Lys 
                85                  90                  95      


Val Cys Phe Leu Ala Thr Gly Gly Gly Arg Leu 
            100                 105         


<210>  133
<211>  166
<212>  PRT
<213>  Homo sapiens

<400>  133

Met Arg Ile Pro Ala Leu Asn Ala Tyr Met Lys Ser Leu Leu Ser Leu 
1               5                   10                  15      


Pro Val Trp Val Leu Met Asp Glu Asp Val Arg Ile Phe Phe Tyr Gln 
            20                  25                  30          


Ser Pro Tyr Asp Ser Glu Gln Val Pro Gln Ala Leu Arg Arg Leu Arg 
        35                  40                  45              


Pro Arg Thr Arg Lys Val Lys Ser Val Ser Pro Gln Gly Asn Ser Val 
    50                  55                  60                  


Asp Arg Met Ala Ala Pro Arg Ala Glu Ala Leu Phe Asp Phe Thr Gly 
65                  70                  75                  80  


Asn Ser Lys Leu Glu Leu Asn Phe Lys Ala Gly Asp Val Ile Phe Leu 
                85                  90                  95      


Leu Ser Arg Ile Asn Lys Asp Trp Leu Glu Gly Thr Val Arg Gly Ala 
            100                 105                 110         


Thr Gly Ile Phe Pro Leu Ser Phe Val Lys Ile Leu Lys Asp Phe Pro 
        115                 120                 125             


Glu Glu Asp Asp Pro Thr Asn Trp Leu Arg Cys Tyr Tyr Tyr Glu Asp 
    130                 135                 140                 


Thr Ile Ser Thr Ile Lys Ser Val Ala Trp Glu Gly Gly Ala Cys Pro 
145                 150                 155                 160 


Ala Phe Leu Pro Ser Leu 
                165     


<210>  134
<211>  889
<212>  PRT
<213>  Homo sapiens

<400>  134

Met Val Leu Ala Gln Gly Leu Leu Ser Met Ala Leu Leu Ala Leu Cys 
1               5                   10                  15      


Trp Glu Arg Ser Leu Ala Gly Ala Glu Glu Thr Ile Pro Leu Gln Thr 
            20                  25                  30          


Leu Arg Cys Tyr Asn Asp Tyr Thr Ser His Ile Thr Cys Arg Trp Ala 
        35                  40                  45              


Asp Thr Gln Asp Ala Gln Arg Leu Val Asn Val Thr Leu Ile Arg Arg 
    50                  55                  60                  


Val Asn Glu Asp Leu Leu Glu Pro Val Ser Cys Asp Leu Ser Asp Asp 
65                  70                  75                  80  


Met Pro Trp Ser Ala Cys Pro His Pro Arg Cys Val Pro Arg Arg Cys 
                85                  90                  95      


Val Ile Pro Cys Gln Ser Phe Val Val Thr Asp Val Asp Tyr Phe Ser 
            100                 105                 110         


Phe Gln Pro Asp Arg Pro Leu Gly Thr Arg Leu Thr Val Thr Leu Thr 
        115                 120                 125             


Gln His Val Gln Pro Pro Glu Pro Arg Asp Leu Gln Ile Ser Thr Asp 
    130                 135                 140                 


Gln Asp His Phe Leu Leu Thr Trp Ser Val Ala Leu Gly Ser Pro Gln 
145                 150                 155                 160 


Ser His Trp Leu Ser Pro Gly Asp Leu Glu Phe Glu Val Val Tyr Lys 
                165                 170                 175     


Arg Leu Gln Asp Ser Trp Glu Asp Ala Ala Ile Leu Leu Ser Asn Thr 
            180                 185                 190         


Ser Gln Ala Thr Leu Gly Pro Glu His Leu Met Pro Ser Ser Thr Tyr 
        195                 200                 205             


Val Ala Arg Val Arg Thr Arg Leu Ala Pro Gly Ser Arg Leu Ser Gly 
    210                 215                 220                 


Arg Pro Ser Lys Trp Ser Pro Glu Val Cys Trp Asp Ser Gln Pro Gly 
225                 230                 235                 240 


Asp Glu Ala Gln Pro Gln Asn Leu Glu Cys Phe Phe Asp Gly Ala Ala 
                245                 250                 255     


Val Leu Ser Cys Ser Trp Glu Val Arg Lys Glu Val Ala Ser Ser Val 
            260                 265                 270         


Ser Phe Gly Leu Phe Tyr Lys Pro Ser Pro Asp Ala Gly Glu Glu Glu 
        275                 280                 285             


Cys Ser Pro Val Leu Arg Glu Gly Leu Gly Ser Leu His Thr Arg His 
    290                 295                 300                 


His Cys Gln Ile Pro Val Pro Asp Pro Ala Thr His Gly Gln Tyr Ile 
305                 310                 315                 320 


Val Ser Val Gln Pro Arg Arg Ala Glu Lys His Ile Lys Ser Ser Val 
                325                 330                 335     


Asn Ile Gln Met Ala Pro Pro Ser Leu Asn Val Thr Lys Asp Gly Asp 
            340                 345                 350         


Ser Tyr Ser Leu Arg Trp Glu Thr Met Lys Met Arg Tyr Glu His Ile 
        355                 360                 365             


Asp His Thr Phe Glu Ile Gln Tyr Arg Lys Asp Thr Ala Thr Trp Lys 
    370                 375                 380                 


Asp Ser Lys Thr Glu Thr Leu Gln Asn Ala His Ser Met Ala Leu Pro 
385                 390                 395                 400 


Ala Leu Glu Pro Ser Thr Arg Tyr Trp Ala Arg Val Arg Val Arg Thr 
                405                 410                 415     


Ser Arg Thr Gly Tyr Asn Gly Ile Trp Ser Glu Trp Ser Glu Ala Arg 
            420                 425                 430         


Ser Trp Asp Thr Glu Ser Val Leu Pro Met Trp Val Leu Ala Leu Ile 
        435                 440                 445             


Val Ile Phe Leu Thr Ile Ala Val Leu Leu Ala Leu Arg Phe Cys Gly 
    450                 455                 460                 


Ile Tyr Gly Tyr Arg Leu Arg Arg Lys Trp Glu Glu Lys Ile Pro Asn 
465                 470                 475                 480 


Pro Ser Lys Ser His Leu Phe Gln Asn Gly Ser Ala Glu Leu Trp Pro 
                485                 490                 495     


Pro Gly Ser Met Ser Ala Phe Thr Ser Gly Ser Pro Pro His Gln Gly 
            500                 505                 510         


Pro Trp Gly Ser Arg Phe Pro Glu Leu Glu Gly Val Phe Pro Val Gly 
        515                 520                 525             


Phe Gly Asp Ser Glu Val Ser Pro Leu Thr Ile Glu Asp Pro Lys His 
    530                 535                 540                 


Val Cys Asp Pro Pro Ser Gly Pro Asp Thr Thr Pro Ala Ala Ser Asp 
545                 550                 555                 560 


Leu Pro Thr Glu Gln Pro Pro Ser Pro Gln Pro Gly Pro Pro Ala Ala 
                565                 570                 575     


Ser His Thr Pro Glu Lys Gln Ala Ser Ser Phe Asp Phe Asn Gly Pro 
            580                 585                 590         


Tyr Leu Gly Pro Pro His Ser Arg Ser Leu Pro Asp Ile Leu Gly Gln 
        595                 600                 605             


Pro Glu Pro Pro Gln Glu Gly Gly Ser Gln Lys Ser Pro Pro Pro Gly 
    610                 615                 620                 


Ser Leu Glu Tyr Leu Cys Leu Pro Ala Gly Gly Gln Val Gln Leu Val 
625                 630                 635                 640 


Pro Leu Ala Gln Ala Met Gly Pro Gly Gln Ala Val Glu Val Glu Arg 
                645                 650                 655     


Arg Pro Ser Gln Gly Ala Ala Gly Ser Pro Ser Leu Glu Ser Gly Gly 
            660                 665                 670         


Gly Pro Ala Pro Pro Ala Leu Gly Pro Arg Val Gly Gly Gln Asp Gln 
        675                 680                 685             


Lys Asp Ser Pro Val Ala Ile Pro Met Ser Ser Gly Asp Thr Glu Asp 
    690                 695                 700                 


Pro Gly Val Ala Ser Gly Tyr Val Ser Ser Ala Asp Leu Val Phe Thr 
705                 710                 715                 720 


Pro Asn Ser Gly Ala Ser Ser Val Ser Leu Val Pro Ser Leu Gly Leu 
                725                 730                 735     


Pro Ser Asp Gln Thr Pro Ser Leu Cys Pro Gly Leu Ala Ser Gly Pro 
            740                 745                 750         


Pro Gly Ala Pro Gly Pro Val Lys Ser Gly Phe Glu Gly Tyr Val Glu 
        755                 760                 765             


Leu Pro Pro Ile Glu Gly Arg Ser Pro Arg Ser Pro Arg Asn Asn Pro 
    770                 775                 780                 


Val Pro Pro Glu Ala Lys Ser Pro Val Leu Asn Pro Gly Glu Arg Pro 
785                 790                 795                 800 


Ala Asp Val Ser Pro Thr Ser Pro Gln Pro Glu Gly Leu Leu Val Leu 
                805                 810                 815     


Gln Gln Val Gly Asp Tyr Cys Phe Leu Pro Gly Leu Gly Pro Gly Pro 
            820                 825                 830         


Leu Ser Leu Arg Ser Lys Pro Ser Ser Pro Gly Pro Gly Pro Glu Ile 
        835                 840                 845             


Lys Asn Leu Asp Gln Ala Phe Gln Val Lys Lys Pro Pro Gly Gln Ala 
    850                 855                 860                 


Val Pro Gln Val Pro Val Ile Gln Leu Phe Lys Ala Leu Val Val Ser 
865                 870                 875                 880 


Val Met Ser Val Gly Pro Pro Val Pro 
                885                 


<210>  135
<211>  897
<212>  PRT
<213>  Homo sapiens

<400>  135

Met Val Leu Ala Gln Gly Leu Leu Ser Met Ala Leu Leu Ala Leu Cys 
1               5                   10                  15      


Trp Glu Arg Ser Leu Ala Gly Ala Glu Glu Thr Ile Pro Leu Gln Thr 
            20                  25                  30          


Leu Arg Cys Tyr Asn Asp Tyr Thr Ser His Ile Thr Cys Arg Trp Ala 
        35                  40                  45              


Asp Thr Gln Asp Ala Gln Arg Leu Val Asn Val Thr Leu Ile Arg Arg 
    50                  55                  60                  


Val Asn Glu Asp Leu Leu Glu Pro Val Ser Cys Asp Leu Ser Asp Asp 
65                  70                  75                  80  


Met Pro Trp Ser Ala Cys Pro His Pro Arg Cys Val Pro Arg Arg Cys 
                85                  90                  95      


Val Ile Pro Cys Gln Ser Phe Val Val Thr Asp Val Asp Tyr Phe Ser 
            100                 105                 110         


Phe Gln Pro Asp Arg Pro Leu Gly Thr Arg Leu Thr Val Thr Leu Thr 
        115                 120                 125             


Gln His Val Gln Pro Pro Glu Pro Arg Asp Leu Gln Ile Ser Thr Asp 
    130                 135                 140                 


Gln Asp His Phe Leu Leu Thr Trp Ser Val Ala Leu Gly Ser Pro Gln 
145                 150                 155                 160 


Ser His Trp Leu Ser Pro Gly Asp Leu Glu Phe Glu Val Val Tyr Lys 
                165                 170                 175     


Arg Leu Gln Asp Ser Trp Glu Asp Ala Ala Ile Leu Leu Ser Asn Thr 
            180                 185                 190         


Ser Gln Ala Thr Leu Gly Pro Glu His Leu Met Pro Ser Ser Thr Tyr 
        195                 200                 205             


Val Ala Arg Val Arg Thr Arg Leu Ala Pro Gly Ser Arg Leu Ser Gly 
    210                 215                 220                 


Arg Pro Ser Lys Trp Ser Pro Glu Val Cys Trp Asp Ser Gln Pro Gly 
225                 230                 235                 240 


Asp Glu Ala Gln Pro Gln Asn Leu Glu Cys Phe Phe Asp Gly Ala Ala 
                245                 250                 255     


Val Leu Ser Cys Ser Trp Glu Val Arg Lys Glu Val Ala Ser Ser Val 
            260                 265                 270         


Ser Phe Gly Leu Phe Tyr Lys Pro Ser Pro Asp Ala Gly Glu Glu Glu 
        275                 280                 285             


Cys Ser Pro Val Leu Arg Glu Gly Leu Gly Ser Leu His Thr Arg His 
    290                 295                 300                 


His Cys Gln Ile Pro Val Pro Asp Pro Ala Thr His Gly Gln Tyr Ile 
305                 310                 315                 320 


Val Ser Val Gln Pro Arg Arg Ala Glu Lys His Ile Lys Ser Ser Val 
                325                 330                 335     


Asn Ile Gln Met Ala Pro Pro Ser Leu Asn Val Thr Lys Asp Gly Asp 
            340                 345                 350         


Ser Tyr Ser Leu Arg Trp Glu Thr Met Lys Met Arg Tyr Glu His Ile 
        355                 360                 365             


Asp His Thr Phe Glu Ile Gln Tyr Arg Lys Asp Thr Ala Thr Trp Lys 
    370                 375                 380                 


Asp Ser Lys Thr Glu Thr Leu Gln Asn Ala His Ser Met Ala Leu Pro 
385                 390                 395                 400 


Ala Leu Glu Pro Ser Thr Arg Tyr Trp Ala Arg Val Arg Val Arg Thr 
                405                 410                 415     


Ser Arg Thr Gly Tyr Asn Gly Ile Trp Ser Glu Trp Ser Glu Ala Arg 
            420                 425                 430         


Ser Trp Asp Thr Glu Ser Val Leu Pro Met Trp Val Leu Ala Leu Ile 
        435                 440                 445             


Val Ile Phe Leu Thr Ile Ala Val Leu Leu Ala Leu Arg Phe Cys Gly 
    450                 455                 460                 


Ile Tyr Gly Tyr Arg Leu Arg Arg Lys Trp Glu Glu Lys Ile Pro Asn 
465                 470                 475                 480 


Pro Ser Lys Ser His Leu Phe Gln Asn Gly Ser Ala Glu Leu Trp Pro 
                485                 490                 495     


Pro Gly Ser Met Ser Ala Phe Thr Ser Gly Ser Pro Pro His Gln Gly 
            500                 505                 510         


Pro Trp Gly Ser Arg Phe Pro Glu Leu Glu Gly Val Phe Pro Val Gly 
        515                 520                 525             


Phe Gly Asp Ser Glu Val Ser Pro Leu Thr Ile Glu Asp Pro Lys His 
    530                 535                 540                 


Val Cys Asp Pro Pro Ser Gly Pro Asp Thr Thr Pro Ala Ala Ser Asp 
545                 550                 555                 560 


Leu Pro Thr Glu Gln Pro Pro Ser Pro Gln Pro Gly Pro Pro Ala Ala 
                565                 570                 575     


Ser His Thr Pro Glu Lys Gln Ala Ser Ser Phe Asp Phe Asn Gly Pro 
            580                 585                 590         


Tyr Leu Gly Pro Pro His Ser Arg Ser Leu Pro Asp Ile Leu Gly Gln 
        595                 600                 605             


Pro Glu Pro Pro Gln Glu Gly Gly Ser Gln Lys Ser Pro Pro Pro Gly 
    610                 615                 620                 


Ser Leu Glu Tyr Leu Cys Leu Pro Ala Gly Gly Gln Val Gln Leu Val 
625                 630                 635                 640 


Pro Leu Ala Gln Ala Met Gly Pro Gly Gln Ala Val Glu Val Glu Arg 
                645                 650                 655     


Arg Pro Ser Gln Gly Ala Ala Gly Ser Pro Ser Leu Glu Ser Gly Gly 
            660                 665                 670         


Gly Pro Ala Pro Pro Ala Leu Gly Pro Arg Val Gly Gly Gln Asp Gln 
        675                 680                 685             


Lys Asp Ser Pro Val Ala Ile Pro Met Ser Ser Gly Asp Thr Glu Asp 
    690                 695                 700                 


Pro Gly Val Ala Ser Gly Tyr Val Ser Ser Ala Asp Leu Val Phe Thr 
705                 710                 715                 720 


Pro Asn Ser Gly Ala Ser Ser Val Ser Leu Val Pro Ser Leu Gly Leu 
                725                 730                 735     


Pro Ser Asp Gln Thr Pro Ser Leu Cys Pro Gly Leu Ala Ser Gly Pro 
            740                 745                 750         


Pro Gly Ala Pro Gly Pro Val Lys Ser Gly Phe Glu Gly Tyr Val Glu 
        755                 760                 765             


Leu Pro Pro Ile Glu Gly Arg Ser Pro Arg Ser Pro Arg Asn Asn Pro 
    770                 775                 780                 


Val Pro Pro Glu Ala Lys Ser Pro Val Leu Asn Pro Gly Glu Arg Pro 
785                 790                 795                 800 


Ala Asp Val Ser Pro Thr Ser Pro Gln Pro Glu Gly Leu Leu Val Leu 
                805                 810                 815     


Gln Gln Val Gly Asp Tyr Cys Phe Leu Pro Gly Leu Gly Pro Gly Pro 
            820                 825                 830         


Leu Ser Leu Arg Ser Lys Pro Ser Ser Pro Gly Pro Gly Pro Glu Ile 
        835                 840                 845             


Lys Asn Leu Asp Gln Ala Phe Gln Val Lys Lys Pro Pro Gly Gln Ala 
    850                 855                 860                 


Val Pro Gln Val Pro Val Ile Gln Leu Phe Lys Ala Leu Lys Gln Gln 
865                 870                 875                 880 


Asp Tyr Leu Ser Leu Pro Pro Trp Glu Val Asn Lys Pro Gly Glu Val 
                885                 890                 895     


Cys 
    


<210>  136
<211>  903
<212>  PRT
<213>  Homo sapiens

<400>  136

Met Val Leu Ala Gln Gly Leu Leu Ser Met Ala Leu Leu Ala Leu Cys 
1               5                   10                  15      


Trp Glu Arg Ser Leu Ala Gly Ala Glu Glu Thr Ile Pro Leu Gln Thr 
            20                  25                  30          


Leu Arg Cys Tyr Asn Asp Tyr Thr Ser His Ile Thr Cys Arg Trp Ala 
        35                  40                  45              


Asp Thr Gln Asp Ala Gln Arg Leu Val Asn Val Thr Leu Ile Arg Arg 
    50                  55                  60                  


Val Asn Glu Asp Leu Leu Glu Pro Val Ser Cys Asp Leu Ser Asp Asp 
65                  70                  75                  80  


Met Pro Trp Ser Ala Cys Pro His Pro Arg Cys Val Pro Arg Arg Cys 
                85                  90                  95      


Val Ile Pro Cys Gln Ser Phe Val Val Thr Asp Val Asp Tyr Phe Ser 
            100                 105                 110         


Phe Gln Pro Asp Arg Pro Leu Gly Thr Arg Leu Thr Val Thr Leu Thr 
        115                 120                 125             


Gln His Val Gln Pro Pro Glu Pro Arg Asp Leu Gln Ile Ser Thr Asp 
    130                 135                 140                 


Gln Asp His Phe Leu Leu Thr Trp Ser Val Ala Leu Gly Ser Pro Gln 
145                 150                 155                 160 


Ser His Trp Leu Ser Pro Gly Asp Leu Glu Phe Glu Val Val Tyr Lys 
                165                 170                 175     


Arg Leu Gln Asp Ser Trp Glu Asp Ala Ala Ile Leu Leu Ser Asn Thr 
            180                 185                 190         


Ser Gln Ala Thr Leu Gly Pro Glu His Leu Met Pro Ser Ser Thr Tyr 
        195                 200                 205             


Val Ala Arg Val Arg Thr Arg Leu Ala Pro Gly Ser Arg Leu Ser Gly 
    210                 215                 220                 


Arg Pro Ser Lys Trp Ser Pro Glu Val Cys Trp Asp Ser Gln Pro Gly 
225                 230                 235                 240 


Asp Glu Ala Gln Pro Gln Asn Leu Glu Cys Phe Phe Asp Gly Ala Ala 
                245                 250                 255     


Val Leu Ser Cys Ser Trp Glu Val Arg Lys Glu Val Ala Ser Ser Val 
            260                 265                 270         


Ser Phe Gly Leu Phe Tyr Lys Pro Ser Pro Asp Ala Gly Ser Ala Val 
        275                 280                 285             


Leu Leu Arg Glu Glu Glu Cys Ser Pro Val Leu Arg Glu Gly Leu Gly 
    290                 295                 300                 


Ser Leu His Thr Arg His His Cys Gln Ile Pro Val Pro Asp Pro Ala 
305                 310                 315                 320 


Thr His Gly Gln Tyr Ile Val Ser Val Gln Pro Arg Arg Ala Glu Lys 
                325                 330                 335     


His Ile Lys Ser Ser Val Asn Ile Gln Met Ala Pro Pro Ser Leu Asn 
            340                 345                 350         


Val Thr Lys Asp Gly Asp Ser Tyr Ser Leu Arg Trp Glu Thr Met Lys 
        355                 360                 365             


Met Arg Tyr Glu His Ile Asp His Thr Phe Glu Ile Gln Tyr Arg Lys 
    370                 375                 380                 


Asp Thr Ala Thr Trp Lys Asp Ser Lys Thr Glu Thr Leu Gln Asn Ala 
385                 390                 395                 400 


His Ser Met Ala Leu Pro Ala Leu Glu Pro Ser Thr Arg Tyr Trp Ala 
                405                 410                 415     


Arg Val Arg Val Arg Thr Ser Arg Thr Gly Tyr Asn Gly Ile Trp Ser 
            420                 425                 430         


Glu Trp Ser Glu Ala Arg Ser Trp Asp Thr Glu Ser Val Leu Pro Met 
        435                 440                 445             


Trp Val Leu Ala Leu Ile Val Ile Phe Leu Thr Ile Ala Val Leu Leu 
    450                 455                 460                 


Ala Leu Arg Phe Cys Gly Ile Tyr Gly Tyr Arg Leu Arg Arg Lys Trp 
465                 470                 475                 480 


Glu Glu Lys Ile Pro Asn Pro Ser Lys Ser His Leu Phe Gln Asn Gly 
                485                 490                 495     


Ser Ala Glu Leu Trp Pro Pro Gly Ser Met Ser Ala Phe Thr Ser Gly 
            500                 505                 510         


Ser Pro Pro His Gln Gly Pro Trp Gly Ser Arg Phe Pro Glu Leu Glu 
        515                 520                 525             


Gly Val Phe Pro Val Gly Phe Gly Asp Ser Glu Val Ser Pro Leu Thr 
    530                 535                 540                 


Ile Glu Asp Pro Lys His Val Cys Asp Pro Pro Ser Gly Pro Asp Thr 
545                 550                 555                 560 


Thr Pro Ala Ala Ser Asp Leu Pro Thr Glu Gln Pro Pro Ser Pro Gln 
                565                 570                 575     


Pro Gly Pro Pro Ala Ala Ser His Thr Pro Glu Lys Gln Ala Ser Ser 
            580                 585                 590         


Phe Asp Phe Asn Gly Pro Tyr Leu Gly Pro Pro His Ser Arg Ser Leu 
        595                 600                 605             


Pro Asp Ile Leu Gly Gln Pro Glu Pro Pro Gln Glu Gly Gly Ser Gln 
    610                 615                 620                 


Lys Ser Pro Pro Pro Gly Ser Leu Glu Tyr Leu Cys Leu Pro Ala Gly 
625                 630                 635                 640 


Gly Gln Val Gln Leu Val Pro Leu Ala Gln Ala Met Gly Pro Gly Gln 
                645                 650                 655     


Ala Val Glu Val Glu Arg Arg Pro Ser Gln Gly Ala Ala Gly Ser Pro 
            660                 665                 670         


Ser Leu Glu Ser Gly Gly Gly Pro Ala Pro Pro Ala Leu Gly Pro Arg 
        675                 680                 685             


Val Gly Gly Gln Asp Gln Lys Asp Ser Pro Val Ala Ile Pro Met Ser 
    690                 695                 700                 


Ser Gly Asp Thr Glu Asp Pro Gly Val Ala Ser Gly Tyr Val Ser Ser 
705                 710                 715                 720 


Ala Asp Leu Val Phe Thr Pro Asn Ser Gly Ala Ser Ser Val Ser Leu 
                725                 730                 735     


Val Pro Ser Leu Gly Leu Pro Ser Asp Gln Thr Pro Ser Leu Cys Pro 
            740                 745                 750         


Gly Leu Ala Ser Gly Pro Pro Gly Ala Pro Gly Pro Val Lys Ser Gly 
        755                 760                 765             


Phe Glu Gly Tyr Val Glu Leu Pro Pro Ile Glu Gly Arg Ser Pro Arg 
    770                 775                 780                 


Ser Pro Arg Asn Asn Pro Val Pro Pro Glu Ala Lys Ser Pro Val Leu 
785                 790                 795                 800 


Asn Pro Gly Glu Arg Pro Ala Asp Val Ser Pro Thr Ser Pro Gln Pro 
                805                 810                 815     


Glu Gly Leu Leu Val Leu Gln Gln Val Gly Asp Tyr Cys Phe Leu Pro 
            820                 825                 830         


Gly Leu Gly Pro Gly Pro Leu Ser Leu Arg Ser Lys Pro Ser Ser Pro 
        835                 840                 845             


Gly Pro Gly Pro Glu Ile Lys Asn Leu Asp Gln Ala Phe Gln Val Lys 
    850                 855                 860                 


Lys Pro Pro Gly Gln Ala Val Pro Gln Val Pro Val Ile Gln Leu Phe 
865                 870                 875                 880 


Lys Ala Leu Lys Gln Gln Asp Tyr Leu Ser Leu Pro Pro Trp Glu Val 
                885                 890                 895     


Asn Lys Pro Gly Glu Val Cys 
            900             


<210>  137
<211>  229
<212>  PRT
<213>  Homo sapiens

<400>  137

Met Pro Trp Ser Ala Cys Pro His Pro Arg Cys Val Pro Arg Arg Cys 
1               5                   10                  15      


Val Ile Pro Cys Gln Ser Phe Val Val Thr Asp Val Asp Tyr Phe Ser 
            20                  25                  30          


Phe Gln Pro Asp Arg Pro Leu Gly Thr Arg Leu Thr Val Thr Leu Thr 
        35                  40                  45              


Gln His Val Gln Pro Pro Glu Pro Arg Asp Leu Gln Ile Ser Thr Asp 
    50                  55                  60                  


Gln Asp His Phe Leu Leu Thr Trp Ser Val Ala Leu Gly Ser Pro Gln 
65                  70                  75                  80  


Ser His Trp Leu Ser Pro Gly Asp Leu Glu Phe Glu Val Val Tyr Lys 
                85                  90                  95      


Arg Leu Gln Asp Ser Trp Glu Asp Ala Ala Ile Leu Leu Ser Asn Thr 
            100                 105                 110         


Ser Gln Ala Thr Leu Gly Pro Glu His Leu Met Pro Ser Ser Thr Tyr 
        115                 120                 125             


Val Ala Arg Val Arg Thr Arg Leu Ala Pro Gly Ser Arg Leu Ser Gly 
    130                 135                 140                 


Arg Pro Ser Lys Trp Ser Pro Glu Val Cys Trp Asp Ser Gln Pro Gly 
145                 150                 155                 160 


Asp Glu Ala Gln Pro Gln Asn Leu Glu Cys Phe Phe Asp Gly Ala Ala 
                165                 170                 175     


Val Leu Ser Cys Ser Trp Glu Val Arg Lys Glu Val Ala Ser Ser Val 
            180                 185                 190         


Ser Phe Gly Leu Phe Tyr Lys Pro Ser Pro Asp Ala Gly Glu Glu Glu 
        195                 200                 205             


Cys Ser Pro Val Leu Arg Glu Gly Leu Gly Ser Leu His Thr Arg His 
    210                 215                 220                 


His Cys Gln Ile Pro 
225                 


<210>  138
<211>  144
<212>  PRT
<213>  Homo sapiens

<400>  138

Met Ala Phe Thr Phe Ala Ala Phe Cys Tyr Met Leu Ala Leu Leu Leu 
1               5                   10                  15      


Thr Ala Ala Leu Ile Phe Phe Ala Ile Trp His Ile Ile Ala Phe Asp 
            20                  25                  30          


Glu Leu Lys Thr Asp Tyr Lys Asn Pro Ile Asp Gln Cys Asn Thr Leu 
        35                  40                  45              


Asn Pro Leu Val Leu Pro Glu Tyr Leu Ile His Ala Phe Phe Cys Val 
    50                  55                  60                  


Met Phe Leu Cys Ala Ala Glu Trp Leu Thr Leu Gly Leu Asn Met Pro 
65                  70                  75                  80  


Leu Leu Ala Tyr His Ile Trp Arg Tyr Met Ser Arg Pro Val Met Ser 
                85                  90                  95      


Gly Pro Gly Leu Tyr Asp Pro Thr Thr Ile Met Asn Ala Asp Ile Leu 
            100                 105                 110         


Ala Tyr Cys Gln Lys Glu Gly Trp Cys Lys Leu Ala Phe Tyr Leu Leu 
        115                 120                 125             


Ala Phe Phe Tyr Tyr Leu Tyr Gly Met Ile Tyr Val Leu Val Ser Ser 
    130                 135                 140                 


<210>  139
<211>  96
<212>  PRT
<213>  Homo sapiens

<400>  139

Met Ala Phe Thr Phe Ala Ala Phe Cys Tyr Met Leu Ala Leu Leu Leu 
1               5                   10                  15      


Thr Ala Ala Leu Ile Phe Phe Ala Ile Trp His Ile Ile Ala Phe Asp 
            20                  25                  30          


Glu Leu Lys Thr Asp Tyr Lys Asn Pro Ile Asp Gln Cys Asn Thr Leu 
        35                  40                  45              


Asn Pro Leu Val Leu Pro Glu Tyr Leu Ile His Ala Phe Phe Cys Val 
    50                  55                  60                  


Met Phe Leu Cys Ala Ala Glu Trp Leu Thr Leu Gly Leu Asn Met Pro 
65                  70                  75                  80  


Leu Leu Ala Tyr His Ile Trp Ser Met Ile Tyr Val Leu Val Ser Ser 
                85                  90                  95      


<210>  140
<211>  121
<212>  PRT
<213>  Homo sapiens

<400>  140

Met Ala Phe Thr Phe Ala Ala Phe Cys Tyr Met Leu Ala Leu Leu Leu 
1               5                   10                  15      


Thr Ala Ala Leu Ile Phe Phe Ala Ile Trp His Leu Val Leu Pro Glu 
            20                  25                  30          


Tyr Leu Ile His Ala Phe Phe Cys Val Met Phe Leu Cys Ala Ala Glu 
        35                  40                  45              


Trp Leu Thr Leu Gly Leu Asn Met Pro Leu Leu Ala Tyr His Ile Trp 
    50                  55                  60                  


Arg Tyr Met Ser Arg Pro Val Met Ser Gly Pro Gly Leu Tyr Asp Pro 
65                  70                  75                  80  


Thr Thr Ile Met Asn Ala Asp Ile Leu Ala Tyr Cys Gln Lys Glu Gly 
                85                  90                  95      


Trp Cys Lys Leu Ala Phe Tyr Leu Leu Ala Phe Phe Tyr Tyr Leu Tyr 
            100                 105                 110         


Gly Met Ile Tyr Val Leu Val Ser Ser 
        115                 120     


<210>  141
<211>  33
<212>  PRT
<213>  Homo sapiens

<400>  141

Met Ala Phe Thr Phe Ala Ala Phe Cys Tyr Met Leu Ala Leu Leu Leu 
1               5                   10                  15      


Thr Ala Ala Leu Ile Phe Phe Ala Ile Trp His Asp Lys Glu Glu Phe 
            20                  25                  30          


Gly 
    


<210>  142
<211>  136
<212>  PRT
<213>  Homo sapiens

<400>  142

Met Ala Phe Thr Phe Ala Ala Phe Cys Tyr Met Leu Ala Leu Leu Leu 
1               5                   10                  15      


Thr Ala Ala Leu Ile Phe Phe Ala Ile Trp His Ile Ile Ala Phe Asp 
            20                  25                  30          


Glu Leu Lys Thr Asp Tyr Lys Asn Pro Ile Asp Gln Cys Asn Thr Leu 
        35                  40                  45              


Asn Pro Leu Val Leu Pro Glu Tyr Leu Ile His Ala Phe Phe Cys Val 
    50                  55                  60                  


Met Phe Leu Cys Ala Ala Glu Trp Leu Thr Leu Gly Leu Asn Met Pro 
65                  70                  75                  80  


Leu Leu Ala Tyr His Ile Trp Arg Tyr Met Ser Arg Pro Val Met Ser 
                85                  90                  95      


Gly Pro Gly Leu Tyr Asp Pro Thr Thr Ile Met Asn Ala Asp Ile Leu 
            100                 105                 110         


Ala Tyr Cys Gln Lys Glu Gly Trp Cys Lys Leu Ala Phe Tyr Leu Leu 
        115                 120                 125             


Ala Phe Phe Tyr Tyr Leu Tyr Gly 
    130                 135     


<210>  143
<211>  53
<212>  PRT
<213>  Homo sapiens

<400>  143

Met Ala Phe Thr Phe Ala Ala Phe Cys Tyr Met Leu Ala Leu Leu Leu 
1               5                   10                  15      


Thr Ala Ala Leu Ile Phe Phe Ala Ile Trp His Ile Ile Ala Phe Asp 
            20                  25                  30          


Glu Leu Lys Thr Asp Tyr Lys Asn Pro Ile Asp Gln Cys Asn Thr Leu 
        35                  40                  45              


Asn Pro Val Tyr Glu 
    50              


<210>  144
<211>  160
<212>  PRT
<213>  Homo sapiens

<400>  144

Met Ala Phe Thr Phe Ala Ala Phe Cys Tyr Met Leu Ala Leu Leu Leu 
1               5                   10                  15      


Thr Ala Ala Leu Ile Phe Phe Ala Ile Trp His Ile Ile Ala Phe Asp 
            20                  25                  30          


Glu Leu Lys Thr Asp Tyr Lys Asn Pro Ile Asp Gln Cys Asn Thr Leu 
        35                  40                  45              


Asn Pro Thr Val Glu Lys Val Lys Lys Ile Lys Arg Val Lys Ile Ala 
    50                  55                  60                  


Leu Lys Leu Val Leu Pro Glu Tyr Leu Ile His Ala Phe Phe Cys Val 
65                  70                  75                  80  


Met Phe Leu Cys Ala Ala Glu Trp Leu Thr Leu Gly Leu Asn Met Pro 
                85                  90                  95      


Leu Leu Ala Tyr His Ile Trp Arg Tyr Met Ser Arg Pro Val Met Ser 
            100                 105                 110         


Gly Pro Gly Leu Tyr Asp Pro Thr Thr Ile Met Asn Ala Asp Ile Leu 
        115                 120                 125             


Ala Tyr Cys Gln Lys Glu Gly Trp Cys Lys Leu Ala Phe Tyr Leu Leu 
    130                 135                 140                 


Ala Phe Phe Tyr Tyr Leu Tyr Gly Met Ile Tyr Val Leu Val Ser Ser 
145                 150                 155                 160 


<210>  145
<211>  435
<212>  PRT
<213>  Homo sapiens

<400>  145

Met Ala Ala Pro Leu Val Leu Val Leu Val Val Ala Val Thr Val Arg 
1               5                   10                  15      


Ala Ala Leu Phe Arg Ser Ser Leu Ala Glu Phe Ile Ser Glu Arg Val 
            20                  25                  30          


Glu Val Val Ser Pro Leu Ser Ser Trp Lys Arg Val Val Glu Gly Leu 
        35                  40                  45              


Ser Leu Leu Asp Leu Gly Val Ser Pro Tyr Ser Gly Ala Val Phe His 
    50                  55                  60                  


Glu Thr Pro Leu Ile Ile Tyr Leu Phe His Phe Leu Ile Asp Tyr Ala 
65                  70                  75                  80  


Glu Leu Val Phe Met Ile Thr Asp Ala Leu Thr Ala Ile Ala Leu Tyr 
                85                  90                  95      


Phe Ala Ile Gln Asp Phe Asn Lys Val Val Phe Lys Lys Gln Lys Leu 
            100                 105                 110         


Leu Leu Glu Leu Asp Gln Tyr Ala Pro Asp Val Ala Glu Leu Ile Arg 
        115                 120                 125             


Thr Pro Met Glu Met Arg Tyr Ile Pro Leu Lys Val Ala Leu Phe Tyr 
    130                 135                 140                 


Leu Leu Asn Pro Tyr Thr Ile Leu Ser Cys Val Ala Lys Ser Thr Cys 
145                 150                 155                 160 


Ala Ile Asn Asn Thr Leu Ile Ala Phe Phe Ile Leu Thr Thr Ile Lys 
                165                 170                 175     


Gly Ser Ala Phe Leu Ser Ala Ile Phe Leu Ala Leu Ala Thr Tyr Gln 
            180                 185                 190         


Ser Leu Tyr Pro Leu Thr Leu Phe Val Pro Gly Leu Leu Tyr Leu Leu 
        195                 200                 205             


Gln Arg Gln Tyr Ile Pro Val Lys Met Lys Ser Lys Ala Phe Trp Ile 
    210                 215                 220                 


Phe Ser Trp Glu Tyr Ala Met Met Tyr Val Gly Ser Leu Val Val Ile 
225                 230                 235                 240 


Ile Cys Leu Ser Phe Phe Leu Leu Ser Ser Trp Asp Phe Ile Pro Ala 
                245                 250                 255     


Val Tyr Gly Phe Ile Leu Ser Val Pro Asp Leu Thr Pro Asn Ile Gly 
            260                 265                 270         


Leu Phe Trp Tyr Phe Phe Ala Glu Met Phe Glu His Phe Ser Leu Phe 
        275                 280                 285             


Phe Val Cys Val Phe Gln Ile Asn Val Phe Phe Tyr Thr Ile Pro Leu 
    290                 295                 300                 


Ala Ile Lys Leu Lys Glu His Pro Ile Phe Phe Met Phe Ile Gln Ile 
305                 310                 315                 320 


Ala Val Ile Ala Ile Phe Lys Ser Tyr Pro Thr Val Gly Asp Val Ala 
                325                 330                 335     


Leu Tyr Met Ala Phe Phe Pro Val Trp Asn His Leu Tyr Arg Phe Leu 
            340                 345                 350         


Arg Asn Ile Phe Val Leu Thr Cys Ile Ile Ile Val Cys Ser Leu Leu 
        355                 360                 365             


Phe Pro Val Leu Trp His Leu Trp Ile Tyr Ala Gly Ser Ala Asn Ser 
    370                 375                 380                 


Asn Phe Phe Tyr Ala Ile Thr Leu Thr Phe Asn Val Gly Gln Ile Leu 
385                 390                 395                 400 


Leu Ile Ser Asp Tyr Phe Tyr Ala Phe Leu Arg Arg Glu Tyr Tyr Leu 
                405                 410                 415     


Thr His Gly Leu Tyr Leu Thr Ala Lys Asp Gly Thr Glu Ala Met Leu 
            420                 425                 430         


Val Leu Lys 
        435 


<210>  146
<211>  415
<212>  PRT
<213>  Homo sapiens

<400>  146

Met Ala Ala Pro Leu Val Leu Val Leu Val Val Ala Val Thr Val Arg 
1               5                   10                  15      


Ala Ala Leu Phe Arg Ser Ser Leu Ala Glu Phe Ile Ser Glu Arg Val 
            20                  25                  30          


Glu Val Val Ser Pro Leu Ser Ser Trp Lys Arg Val Val Glu Gly Leu 
        35                  40                  45              


Ser Leu Leu Asp Leu Gly Val Ser Pro Tyr Ser Gly Ala Val Phe His 
    50                  55                  60                  


Glu Ile Thr Asp Ala Leu Thr Ala Ile Ala Leu Tyr Phe Ala Ile Gln 
65                  70                  75                  80  


Asp Phe Asn Lys Val Val Phe Lys Lys Gln Lys Leu Leu Leu Glu Leu 
                85                  90                  95      


Asp Gln Tyr Ala Pro Asp Val Ala Glu Leu Ile Arg Thr Pro Met Glu 
            100                 105                 110         


Met Arg Tyr Ile Pro Leu Lys Val Ala Leu Phe Tyr Leu Leu Asn Pro 
        115                 120                 125             


Tyr Thr Ile Leu Ser Cys Val Ala Lys Ser Thr Cys Ala Ile Asn Asn 
    130                 135                 140                 


Thr Leu Ile Ala Phe Phe Ile Leu Thr Thr Ile Lys Gly Ser Ala Phe 
145                 150                 155                 160 


Leu Ser Ala Ile Phe Leu Ala Leu Ala Thr Tyr Gln Ser Leu Tyr Pro 
                165                 170                 175     


Leu Thr Leu Phe Val Pro Gly Leu Leu Tyr Leu Leu Gln Arg Gln Tyr 
            180                 185                 190         


Ile Pro Val Lys Met Lys Ser Lys Ala Phe Trp Ile Phe Ser Trp Glu 
        195                 200                 205             


Tyr Ala Met Met Tyr Val Gly Ser Leu Val Val Ile Ile Cys Leu Ser 
    210                 215                 220                 


Phe Phe Leu Leu Ser Ser Trp Asp Phe Ile Pro Ala Val Tyr Gly Phe 
225                 230                 235                 240 


Ile Leu Ser Val Pro Asp Leu Thr Pro Asn Ile Gly Leu Phe Trp Tyr 
                245                 250                 255     


Phe Phe Ala Glu Met Phe Glu His Phe Ser Leu Phe Phe Val Cys Val 
            260                 265                 270         


Phe Gln Ile Asn Val Phe Phe Tyr Thr Ile Pro Leu Ala Ile Lys Leu 
        275                 280                 285             


Lys Glu His Pro Ile Phe Phe Met Phe Ile Gln Ile Ala Val Ile Ala 
    290                 295                 300                 


Ile Phe Lys Ser Tyr Pro Thr Val Gly Asp Val Ala Leu Tyr Met Ala 
305                 310                 315                 320 


Phe Phe Pro Val Trp Asn His Leu Tyr Arg Phe Leu Arg Asn Ile Phe 
                325                 330                 335     


Val Leu Thr Cys Ile Ile Ile Val Cys Ser Leu Leu Phe Pro Val Leu 
            340                 345                 350         


Trp His Leu Trp Ile Tyr Ala Gly Ser Ala Asn Ser Asn Phe Phe Tyr 
        355                 360                 365             


Ala Ile Thr Leu Thr Phe Asn Val Gly Gln Ile Leu Leu Ile Ser Asp 
    370                 375                 380                 


Tyr Phe Tyr Ala Phe Leu Arg Arg Glu Tyr Tyr Leu Thr His Gly Leu 
385                 390                 395                 400 


Tyr Leu Thr Ala Lys Asp Gly Thr Glu Ala Met Leu Val Leu Lys 
                405                 410                 415 


<210>  147
<211>  170
<212>  PRT
<213>  Homo sapiens

<400>  147

Val Ser Val Pro Thr His Leu Val Cys Pro Arg Thr Pro Leu Ser Pro 
1               5                   10                  15      


Pro Ala Ala Val His Thr Cys Glu Asn Glu Glu Gln Ser Leu Leu Asp 
            20                  25                  30          


Leu Phe Leu Gly Val Cys His Asp Ile Asn Val Phe Phe Tyr Thr Ile 
        35                  40                  45              


Pro Leu Ala Ile Lys Leu Lys Glu His Pro Ile Phe Phe Met Phe Ile 
    50                  55                  60                  


Gln Ile Ala Val Ile Ala Ile Phe Lys Ser Tyr Pro Thr Val Gly Asp 
65                  70                  75                  80  


Val Ala Leu Tyr Met Ala Phe Phe Pro Val Trp Asn His Leu Tyr Arg 
                85                  90                  95      


Phe Leu Arg Asn Ile Phe Val Leu Thr Cys Ile Ile Ile Val Cys Ser 
            100                 105                 110         


Leu Leu Phe Pro Val Leu Trp His Leu Trp Ile Tyr Ala Gly Ser Ala 
        115                 120                 125             


Asn Ser Asn Phe Phe Tyr Ala Ile Thr Leu Thr Phe Asn Val Gly Gln 
    130                 135                 140                 


Ile Leu Leu Ile Ser Asp Tyr Phe Tyr Ala Phe Leu Arg Arg Glu Tyr 
145                 150                 155                 160 


Tyr Leu Thr His Gly Leu Tyr Leu Thr Ala 
                165                 170 


<210>  148
<211>  336
<212>  PRT
<213>  Homo sapiens

<400>  148

Met Ala Arg Arg Arg Ser Gln Arg Val Cys Ala Ser Gly Pro Ser Met 
1               5                   10                  15      


Leu Asn Ser Ala Arg Gly Ala Pro Glu Leu Leu Arg Gly Thr Ala Thr 
            20                  25                  30          


Asn Ala Glu Val Ser Ala Ala Ala Ala Gly Ala Thr Gly Ser Glu Glu 
        35                  40                  45              


Leu Pro Pro Gly Asp Arg Gly Cys Arg Asn Gly Gly Gly Arg Gly Pro 
    50                  55                  60                  


Ala Ala Thr Thr Ser Ser Thr Gly Val Ala Val Gly Ala Glu His Gly 
65                  70                  75                  80  


Glu Asp Ser Leu Ser Arg Lys Pro Asp Pro Glu Pro Gly Arg Met Asp 
                85                  90                  95      


His His Gln Pro Gly Thr Gly Arg Tyr Gln Val Leu Leu Asn Glu Glu 
            100                 105                 110         


Asp Asn Ser Glu Ser Ser Ala Ile Glu Gln Pro Pro Thr Ser Asn Pro 
        115                 120                 125             


Ala Pro Gln Ile Val Gln Ala Ala Ser Ser Ala Pro Ala Leu Glu Thr 
    130                 135                 140                 


Asp Ser Ser Pro Pro Pro Tyr Ser Ser Ile Thr Val Glu Val Pro Thr 
145                 150                 155                 160 


Thr Ser Asp Thr Glu Val Tyr Gly Glu Phe Tyr Pro Val Pro Pro Pro 
                165                 170                 175     


Tyr Ser Val Ala Thr Ser Leu Pro Thr Tyr Asp Glu Ala Glu Lys Ala 
            180                 185                 190         


Lys Ala Ala Ala Met Ala Ala Ala Ala Ala Glu Thr Ser Gln Arg Ile 
        195                 200                 205             


Gln Glu Glu Glu Cys Pro Pro Arg Asp Asp Phe Ser Asp Ala Asp Gln 
    210                 215                 220                 


Leu Arg Val Gly Asn Asp Gly Ile Phe Met Leu Ala Phe Phe Met Ala 
225                 230                 235                 240 


Phe Ile Phe Asn Trp Leu Gly Phe Cys Leu Ser Phe Cys Ile Thr Asn 
                245                 250                 255     


Thr Ile Ala Gly Arg Tyr Gly Ala Ile Cys Gly Phe Gly Leu Ser Leu 
            260                 265                 270         


Ile Lys Trp Ile Leu Ile Val Arg Phe Ser Asp Tyr Phe Thr Gly Tyr 
        275                 280                 285             


Phe Asn Gly Gln Tyr Trp Leu Trp Trp Ile Phe Leu Val Leu Gly Leu 
    290                 295                 300                 


Leu Leu Phe Phe Arg Gly Phe Val Asn Tyr Leu Lys Val Arg Asn Met 
305                 310                 315                 320 


Ser Glu Ser Met Ala Ala Ala His Arg Thr Arg Tyr Phe Phe Leu Leu 
                325                 330                 335     


<210>  149
<211>  222
<212>  PRT
<213>  Homo sapiens

<400>  149

Met Asp His His Gln Pro Gly Thr Gly Arg Tyr Gln Val Leu Leu Asn 
1               5                   10                  15      


Glu Glu Asp Asn Ser Glu Ser Ser Ala Ile Glu Gln Pro Pro Thr Ser 
            20                  25                  30          


Asn Pro Ala Pro Gln Ile Val Gln Ala Ala Ser Ser Ala Pro Ala Leu 
        35                  40                  45              


Glu Thr Asp Ser Ser Pro Pro Pro Tyr Ser Ser Ile Thr Val Glu Val 
    50                  55                  60                  


Pro Thr Thr Ser Asp Thr Glu Val Tyr Gly Glu Phe Tyr Pro Val Pro 
65                  70                  75                  80  


Pro Pro Tyr Ser Val Ala Thr Ser Leu Pro Thr Tyr Asp Glu Ala Glu 
                85                  90                  95      


Lys Ala Lys Ala Ala Ala Met Ala Ala Ala Ala Ala Glu Thr Ser Gln 
            100                 105                 110         


Arg Ile Gln Glu Glu Glu Cys Pro Pro Arg Asp Asp Phe Ser Asp Ala 
        115                 120                 125             


Asp Gln Leu Arg Val Gly Asn Asp Gly Ile Phe Met Leu Ala Phe Phe 
    130                 135                 140                 


Thr Gly Arg Tyr Gly Ala Ile Cys Gly Phe Gly Leu Ser Leu Ile Lys 
145                 150                 155                 160 


Trp Ile Leu Ile Val Arg Phe Ser Asp Tyr Phe Thr Gly Tyr Phe Asn 
                165                 170                 175     


Gly Gln Tyr Trp Leu Trp Trp Ile Phe Leu Val Leu Gly Leu Leu Leu 
            180                 185                 190         


Phe Phe Arg Gly Phe Val Asn Tyr Leu Lys Val Arg Asn Met Ser Glu 
        195                 200                 205             


Ser Met Ala Ala Ala His Arg Thr Arg Tyr Phe Phe Leu Leu 
    210                 215                 220         


<210>  150
<211>  336
<212>  PRT
<213>  Homo sapiens

<400>  150

Met Ala Arg Arg Arg Ser Gln Arg Val Cys Ala Ser Gly Pro Ser Met 
1               5                   10                  15      


Leu Asn Ser Ala Arg Gly Ala Pro Glu Leu Leu Arg Gly Thr Ala Thr 
            20                  25                  30          


Asn Ala Glu Val Ser Ala Ala Ala Ala Gly Ala Thr Gly Ser Glu Glu 
        35                  40                  45              


Leu Pro Pro Gly Asp Arg Gly Cys Arg Asn Gly Gly Gly Arg Gly Pro 
    50                  55                  60                  


Ala Ala Thr Thr Ser Ser Thr Gly Val Ala Val Gly Ala Glu His Gly 
65                  70                  75                  80  


Glu Asp Ser Leu Ser Arg Lys Pro Asp Pro Glu Pro Gly Arg Met Asp 
                85                  90                  95      


His His Gln Pro Gly Thr Gly Arg Tyr Gln Val Leu Leu Asn Glu Glu 
            100                 105                 110         


Asp Asn Ser Glu Ser Ser Ala Ile Glu Gln Pro Pro Thr Ser Asn Pro 
        115                 120                 125             


Ala Pro Gln Ile Val Gln Ala Ala Ser Ser Ala Pro Ala Leu Glu Thr 
    130                 135                 140                 


Asp Ser Ser Pro Pro Pro Tyr Ser Ser Ile Thr Val Glu Val Pro Thr 
145                 150                 155                 160 


Thr Ser Asp Thr Glu Val Tyr Gly Glu Phe Tyr Pro Val Pro Pro Pro 
                165                 170                 175     


Tyr Ser Val Ala Thr Ser Leu Pro Thr Tyr Asp Glu Ala Glu Lys Ala 
            180                 185                 190         


Lys Ala Ala Ala Met Ala Ala Ala Ala Ala Glu Thr Ser Gln Arg Ile 
        195                 200                 205             


Gln Glu Glu Glu Cys Pro Pro Arg Asp Asp Phe Ser Asp Ala Asp Gln 
    210                 215                 220                 


Leu Arg Val Gly Asn Asp Gly Ile Phe Met Leu Ala Phe Phe Met Ala 
225                 230                 235                 240 


Phe Ile Phe Asn Trp Leu Gly Phe Cys Leu Ser Phe Cys Ile Thr Asn 
                245                 250                 255     


Thr Ile Ala Gly Arg Tyr Gly Ala Ile Cys Gly Phe Gly Leu Ser Leu 
            260                 265                 270         


Ile Lys Trp Ile Leu Ile Val Arg Phe Ser Asp Tyr Phe Thr Gly Tyr 
        275                 280                 285             


Phe Asn Gly Gln Tyr Trp Leu Trp Trp Ile Phe Leu Val Leu Gly Leu 
    290                 295                 300                 


Leu Leu Phe Phe Arg Gly Phe Val Asn Tyr Leu Lys Val Arg Asn Met 
305                 310                 315                 320 


Ser Glu Ser Met Ala Ala Ala His Arg Thr Arg Tyr Phe Phe Leu Leu 
                325                 330                 335     


<210>  151
<211>  242
<212>  PRT
<213>  Homo sapiens

<400>  151

Met Asp His His Gln Pro Gly Thr Gly Arg Tyr Gln Val Leu Leu Asn 
1               5                   10                  15      


Glu Glu Asp Asn Ser Glu Ser Ser Ala Ile Glu Gln Pro Pro Thr Ser 
            20                  25                  30          


Asn Pro Ala Pro Gln Ile Val Gln Ala Ala Ser Ser Ala Pro Ala Leu 
        35                  40                  45              


Glu Thr Asp Ser Ser Pro Pro Pro Tyr Ser Ser Ile Thr Val Glu Val 
    50                  55                  60                  


Pro Thr Thr Ser Asp Thr Glu Val Tyr Gly Glu Phe Tyr Pro Val Pro 
65                  70                  75                  80  


Pro Pro Tyr Ser Val Ala Thr Ser Leu Pro Thr Tyr Asp Glu Ala Glu 
                85                  90                  95      


Lys Ala Lys Ala Ala Ala Met Ala Ala Ala Ala Ala Glu Thr Ser Gln 
            100                 105                 110         


Arg Ile Gln Glu Glu Glu Cys Pro Pro Arg Asp Asp Phe Ser Asp Ala 
        115                 120                 125             


Asp Gln Leu Arg Val Gly Asn Asp Gly Ile Phe Met Leu Ala Phe Phe 
    130                 135                 140                 


Met Ala Phe Ile Phe Asn Trp Leu Gly Phe Cys Leu Ser Phe Cys Ile 
145                 150                 155                 160 


Thr Asn Thr Ile Ala Gly Arg Tyr Gly Ala Ile Cys Gly Phe Gly Leu 
                165                 170                 175     


Ser Leu Ile Lys Trp Ile Leu Ile Val Arg Phe Ser Asp Tyr Phe Thr 
            180                 185                 190         


Gly Tyr Phe Asn Gly Gln Tyr Trp Leu Trp Trp Ile Phe Leu Val Leu 
        195                 200                 205             


Gly Leu Leu Leu Phe Phe Arg Gly Phe Val Asn Tyr Leu Lys Val Arg 
    210                 215                 220                 


Asn Met Ser Glu Ser Met Ala Ala Ala His Arg Thr Arg Tyr Phe Phe 
225                 230                 235                 240 


Leu Leu 
        


<210>  152
<211>  325
<212>  PRT
<213>  Homo sapiens

<400>  152

Met Asp Met Trp Thr Ala Leu Leu Ile Leu Gln Ala Leu Leu Leu Pro 
1               5                   10                  15      


Ser Leu Ala Asp Gly Ala Thr Pro Ala Leu Arg Phe Val Ala Val Gly 
            20                  25                  30          


Asp Trp Gly Gly Val Pro Asn Ala Pro Phe His Thr Ala Arg Glu Met 
        35                  40                  45              


Ala Asn Ala Lys Glu Ile Ala Arg Thr Val Gln Ile Leu Gly Ala Asp 
    50                  55                  60                  


Phe Ile Leu Ser Leu Gly Asp Asn Phe Tyr Phe Thr Gly Val Gln Asp 
65                  70                  75                  80  


Ile Asn Asp Lys Arg Phe Gln Glu Thr Phe Glu Asp Val Phe Ser Asp 
                85                  90                  95      


Arg Ser Leu Arg Lys Val Pro Trp Tyr Val Leu Ala Gly Asn His Asp 
            100                 105                 110         


His Leu Gly Asn Val Ser Ala Gln Ile Ala Tyr Ser Lys Ile Ser Lys 
        115                 120                 125             


Arg Trp Asn Phe Pro Ser Pro Phe Tyr Arg Leu His Phe Lys Ile Pro 
    130                 135                 140                 


Gln Thr Asn Val Ser Val Ala Ile Phe Met Leu Asp Thr Val Thr Leu 
145                 150                 155                 160 


Cys Gly Asn Ser Asp Asp Phe Leu Ser Gln Gln Pro Glu Arg Pro Arg 
                165                 170                 175     


Asp Val Lys Leu Ala Arg Thr Gln Leu Ser Trp Leu Lys Lys Gln Leu 
            180                 185                 190         


Ala Ala Ala Arg Glu Asp Tyr Val Leu Val Ala Gly His Tyr Pro Val 
        195                 200                 205             


Trp Ser Ile Ala Glu His Gly Pro Thr His Cys Leu Val Lys Gln Leu 
    210                 215                 220                 


Arg Pro Leu Leu Ala Thr Tyr Gly Val Thr Ala Tyr Leu Cys Gly His 
225                 230                 235                 240 


Asp His Asn Leu Gln Tyr Leu Gln Asp Glu Asn Gly Val Gly Tyr Val 
                245                 250                 255     


Leu Ser Gly Ala Gly Asn Phe Met Asp Pro Ser Lys Arg His Gln Arg 
            260                 265                 270         


Lys Val Pro Asn Gly Tyr Leu Arg Phe His Tyr Gly Thr Glu Asp Ser 
        275                 280                 285             


Leu Gly Gly Phe Ala Tyr Val Glu Ile Ser Ser Lys Glu Met Thr Val 
    290                 295                 300                 


Thr Tyr Ile Glu Ala Ser Gly Lys Ser Leu Phe Lys Thr Arg Leu Pro 
305                 310                 315                 320 


Arg Arg Ala Arg Pro 
                325 


<210>  153
<211>  325
<212>  PRT
<213>  Homo sapiens

<400>  153

Met Asp Met Trp Thr Ala Leu Leu Ile Leu Gln Ala Leu Leu Leu Pro 
1               5                   10                  15      


Ser Leu Ala Asp Gly Ala Thr Pro Ala Leu Arg Phe Val Ala Val Gly 
            20                  25                  30          


Asp Trp Gly Gly Val Pro Asn Ala Pro Phe His Thr Ala Arg Glu Met 
        35                  40                  45              


Ala Asn Ala Lys Glu Ile Ala Arg Thr Val Gln Ile Leu Gly Ala Asp 
    50                  55                  60                  


Phe Ile Leu Ser Leu Gly Asp Asn Phe Tyr Phe Thr Gly Val Gln Asp 
65                  70                  75                  80  


Ile Asn Asp Lys Arg Phe Gln Glu Thr Phe Glu Asp Val Phe Ser Asp 
                85                  90                  95      


Arg Ser Leu Arg Lys Val Pro Trp Tyr Val Leu Ala Gly Asn His Asp 
            100                 105                 110         


His Leu Gly Asn Val Ser Ala Gln Ile Ala Tyr Ser Lys Ile Ser Lys 
        115                 120                 125             


Arg Trp Asn Phe Pro Ser Pro Phe Tyr Arg Leu His Phe Lys Ile Pro 
    130                 135                 140                 


Gln Thr Asn Val Ser Val Ala Ile Phe Met Leu Asp Thr Val Thr Leu 
145                 150                 155                 160 


Cys Gly Asn Ser Asp Asp Phe Leu Ser Gln Gln Pro Glu Arg Pro Arg 
                165                 170                 175     


Asp Val Lys Leu Ala Arg Thr Gln Leu Ser Trp Leu Lys Lys Gln Leu 
            180                 185                 190         


Ala Ala Ala Arg Glu Asp Tyr Val Leu Val Ala Gly His Tyr Pro Val 
        195                 200                 205             


Trp Ser Ile Ala Glu His Gly Pro Thr His Cys Leu Val Lys Gln Leu 
    210                 215                 220                 


Arg Pro Leu Leu Ala Thr Tyr Gly Val Thr Ala Tyr Leu Cys Gly His 
225                 230                 235                 240 


Asp His Asn Leu Gln Tyr Leu Gln Asp Glu Asn Gly Val Gly Tyr Val 
                245                 250                 255     


Leu Ser Gly Ala Gly Asn Phe Met Asp Pro Ser Lys Arg His Gln Arg 
            260                 265                 270         


Lys Val Pro Asn Gly Tyr Leu Arg Phe His Tyr Gly Thr Glu Asp Ser 
        275                 280                 285             


Leu Gly Gly Phe Ala Tyr Val Glu Ile Ser Ser Lys Glu Met Thr Val 
    290                 295                 300                 


Thr Tyr Ile Glu Ala Ser Gly Lys Ser Leu Phe Lys Thr Arg Leu Pro 
305                 310                 315                 320 


Arg Arg Ala Arg Pro 
                325 


<210>  154
<211>  325
<212>  PRT
<213>  Homo sapiens

<400>  154

Met Asp Met Trp Thr Ala Leu Leu Ile Leu Gln Ala Leu Leu Leu Pro 
1               5                   10                  15      


Ser Leu Ala Asp Gly Ala Thr Pro Ala Leu Arg Phe Val Ala Val Gly 
            20                  25                  30          


Asp Trp Gly Gly Val Pro Asn Ala Pro Phe His Thr Ala Arg Glu Met 
        35                  40                  45              


Ala Asn Ala Lys Glu Ile Ala Arg Thr Val Gln Ile Leu Gly Ala Asp 
    50                  55                  60                  


Phe Ile Leu Ser Leu Gly Asp Asn Phe Tyr Phe Thr Gly Val Gln Asp 
65                  70                  75                  80  


Ile Asn Asp Lys Arg Phe Gln Glu Thr Phe Glu Asp Val Phe Ser Asp 
                85                  90                  95      


Arg Ser Leu Arg Lys Val Pro Trp Tyr Val Leu Ala Gly Asn His Asp 
            100                 105                 110         


His Leu Gly Asn Val Ser Ala Gln Ile Ala Tyr Ser Lys Ile Ser Lys 
        115                 120                 125             


Arg Trp Asn Phe Pro Ser Pro Phe Tyr Arg Leu His Phe Lys Ile Pro 
    130                 135                 140                 


Gln Thr Asn Val Ser Val Ala Ile Phe Met Leu Asp Thr Val Thr Leu 
145                 150                 155                 160 


Cys Gly Asn Ser Asp Asp Phe Leu Ser Gln Gln Pro Glu Arg Pro Arg 
                165                 170                 175     


Asp Val Lys Leu Ala Arg Thr Gln Leu Ser Trp Leu Lys Lys Gln Leu 
            180                 185                 190         


Ala Ala Ala Arg Glu Asp Tyr Val Leu Val Ala Gly His Tyr Pro Val 
        195                 200                 205             


Trp Ser Ile Ala Glu His Gly Pro Thr His Cys Leu Val Lys Gln Leu 
    210                 215                 220                 


Arg Pro Leu Leu Ala Thr Tyr Gly Val Thr Ala Tyr Leu Cys Gly His 
225                 230                 235                 240 


Asp His Asn Leu Gln Tyr Leu Gln Asp Glu Asn Gly Val Gly Tyr Val 
                245                 250                 255     


Leu Ser Gly Ala Gly Asn Phe Met Asp Pro Ser Lys Arg His Gln Arg 
            260                 265                 270         


Lys Val Pro Asn Gly Tyr Leu Arg Phe His Tyr Gly Thr Glu Asp Ser 
        275                 280                 285             


Leu Gly Gly Phe Ala Tyr Val Glu Ile Ser Ser Lys Glu Met Thr Val 
    290                 295                 300                 


Thr Tyr Ile Glu Ala Ser Gly Lys Ser Leu Phe Lys Thr Arg Leu Pro 
305                 310                 315                 320 


Arg Arg Ala Arg Pro 
                325 


<210>  155
<211>  74
<212>  PRT
<213>  Homo sapiens

<400>  155

Met Asp Met Trp Thr Ala Leu Leu Ile Leu Gln Ala Leu Leu Leu Pro 
1               5                   10                  15      


Ser Leu Ala Asp Gly Ala Thr Pro Ala Leu Arg Phe Val Ala Val Gly 
            20                  25                  30          


Asp Trp Gly Gly Val Pro Asn Ala Pro Phe His Thr Ala Arg Glu Met 
        35                  40                  45              


Ala Asn Ala Lys Glu Ile Ala Arg Thr Val Gln Ile Leu Gly Ala Asp 
    50                  55                  60                  


Phe Ile Leu Ser Leu Gly Asp Asn Phe Tyr 
65                  70                  


<210>  156
<211>  59
<212>  PRT
<213>  Homo sapiens

<400>  156

Met Asp Met Trp Thr Ala Leu Leu Ile Leu Gln Ala Leu Leu Leu Pro 
1               5                   10                  15      


Ser Leu Gly Ile Ser Trp Thr Pro Gln Ser Gly Thr Ser Ala Arg Ser 
            20                  25                  30          


Pro Thr Ala Ile Cys Ala Ser Thr Met Gly Leu Lys Thr His Trp Val 
        35                  40                  45              


Ala Leu Pro Met Trp Arg Ser Ala Pro Lys Arg 
    50                  55                  


<210>  157
<211>  124
<212>  PRT
<213>  Homo sapiens

<400>  157

Met Asp Met Trp Thr Ala Leu Leu Ile Leu Gln Ala Leu Leu Leu Pro 
1               5                   10                  15      


Ser Leu Ala Asp Gly Ala Thr Pro Ala Leu Arg Phe Val Ala Val Gly 
            20                  25                  30          


Asp Trp Gly Gly Val Pro Asn Ala Pro Phe His Thr Ala Arg Glu Met 
        35                  40                  45              


Ala Asn Ala Lys Glu Ile Ala Arg Thr Val Gln Ile Leu Gly Ala Asp 
    50                  55                  60                  


Phe Ile Leu Ser Leu Gly Asp Asn Phe Tyr Phe Thr Gly Val Gln Asp 
65                  70                  75                  80  


Ile Asn Asp Lys Arg Phe Gln Glu Thr Phe Glu Asp Val Phe Ser Asp 
                85                  90                  95      


Arg Ser Leu Arg Lys Val Pro Trp Tyr Val Leu Ala Gly Asn His Asp 
            100                 105                 110         


His Leu Gly Asn Val Ser Ala Gln Ile Ala Tyr Ser 
        115                 120                 


<210>  158
<211>  52
<212>  PRT
<213>  Homo sapiens

<400>  158

Met Asp Met Trp Thr Ala Leu Leu Ile Leu Gln Ala Leu Leu Leu Pro 
1               5                   10                  15      


Ser Leu Ala Asp Gly Ala Thr Pro Ala Leu Arg Phe Val Ala Val Gly 
            20                  25                  30          


Asp Trp Gly Gly Val Pro Asn Ala Pro Phe His Thr Ala Arg Glu Met 
        35                  40                  45              


Ala Asn Ala Lys 
    50          


<210>  159
<211>  325
<212>  PRT
<213>  Homo sapiens

<400>  159

Met Asp Met Trp Thr Ala Leu Leu Ile Leu Gln Ala Leu Leu Leu Pro 
1               5                   10                  15      


Ser Leu Ala Asp Gly Ala Thr Pro Ala Leu Arg Phe Val Ala Val Gly 
            20                  25                  30          


Asp Trp Gly Gly Val Pro Asn Ala Pro Phe His Thr Ala Arg Glu Met 
        35                  40                  45              


Ala Asn Ala Lys Glu Ile Ala Arg Thr Val Gln Ile Leu Gly Ala Asp 
    50                  55                  60                  


Phe Ile Leu Ser Leu Gly Asp Asn Phe Tyr Phe Thr Gly Val Gln Asp 
65                  70                  75                  80  


Ile Asn Asp Lys Arg Phe Gln Glu Thr Phe Glu Asp Val Phe Ser Asp 
                85                  90                  95      


Arg Ser Leu Arg Lys Val Pro Trp Tyr Val Leu Ala Gly Asn His Asp 
            100                 105                 110         


His Leu Gly Asn Val Ser Ala Gln Ile Ala Tyr Ser Lys Ile Ser Lys 
        115                 120                 125             


Arg Trp Asn Phe Pro Ser Pro Phe Tyr Arg Leu His Phe Lys Ile Pro 
    130                 135                 140                 


Gln Thr Asn Val Ser Val Ala Ile Phe Met Leu Asp Thr Val Thr Leu 
145                 150                 155                 160 


Cys Gly Asn Ser Asp Asp Phe Leu Ser Gln Gln Pro Glu Arg Pro Arg 
                165                 170                 175     


Asp Val Lys Leu Ala Arg Thr Gln Leu Ser Trp Leu Lys Lys Gln Leu 
            180                 185                 190         


Ala Ala Ala Arg Glu Asp Tyr Val Leu Val Ala Gly His Tyr Pro Val 
        195                 200                 205             


Trp Ser Ile Ala Glu His Gly Pro Thr His Cys Leu Val Lys Gln Leu 
    210                 215                 220                 


Arg Pro Leu Leu Ala Thr Tyr Gly Val Thr Ala Tyr Leu Cys Gly His 
225                 230                 235                 240 


Asp His Asn Leu Gln Tyr Leu Gln Asp Glu Asn Gly Val Gly Tyr Val 
                245                 250                 255     


Leu Ser Gly Ala Gly Asn Phe Met Asp Pro Ser Lys Arg His Gln Arg 
            260                 265                 270         


Lys Val Pro Asn Gly Tyr Leu Arg Phe His Tyr Gly Thr Glu Asp Ser 
        275                 280                 285             


Leu Gly Gly Phe Ala Tyr Val Glu Ile Ser Ser Lys Glu Met Thr Val 
    290                 295                 300                 


Thr Tyr Ile Glu Ala Ser Gly Lys Ser Leu Phe Lys Thr Arg Leu Pro 
305                 310                 315                 320 


Arg Arg Ala Arg Pro 
                325 


<210>  160
<211>  119
<212>  PRT
<213>  Homo sapiens

<400>  160

Met Pro Ser Asp Phe Ile Ser Leu Leu Ser Ala Asp Leu Asp Leu Glu 
1               5                   10                  15      


Ser Pro Lys Ser Leu Tyr Ser Arg Asp Ser Leu Lys Leu His Pro Ser 
            20                  25                  30          


Gln Asn Phe His Arg Ala Gly Leu Leu Glu Glu Ser Val Tyr Asp Leu 
        35                  40                  45              


Leu Pro Lys Glu Leu Gln Leu Pro Pro Ser Arg Glu Thr Ser Val Ala 
    50                  55                  60                  


Ser Met Ser Gln Thr Ser Gly Gly Glu Ala Gly Ser Pro Pro Pro Ala 
65                  70                  75                  80  


Val Val Ala Ala Gly Ile Pro Glu Met Phe Ile Leu Cys Ile Leu Met 
                85                  90                  95      


Cys Met Ile Leu Arg Phe Lys Lys Gly Phe Ala Ser Glu Ala Gly Ser 
            100                 105                 110         


Val Cys Ile Lys Asn Asp Leu 
        115                 


<210>  161
<211>  150
<212>  PRT
<213>  Homo sapiens

<400>  161

Met Ser Gly Ser Met Ala Thr Ala Glu Ala Ser Gly Ser Asp Gly Lys 
1               5                   10                  15      


Gly Gln Glu Val Glu Thr Ser Val Thr Tyr Tyr Arg Leu Glu Glu Val 
            20                  25                  30          


Ala Lys Arg Asn Ser Leu Lys Glu Leu Trp Leu Val Ile His Gly Arg 
        35                  40                  45              


Val Tyr Asp Val Thr Arg Phe Leu Asn Glu His Pro Gly Gly Glu Glu 
    50                  55                  60                  


Val Leu Leu Glu Gln Ala Gly Val Asp Ala Ser Glu Ser Phe Glu Asp 
65                  70                  75                  80  


Val Gly His Ser Ser Asp Ala Arg Glu Met Leu Lys Gln Tyr Tyr Ile 
                85                  90                  95      


Gly Asp Ile His Pro Ser Asp Leu Lys Pro Glu Ser Gly Ser Lys Asp 
            100                 105                 110         


Pro Ser Lys Asn Asp Thr Cys Lys Ser Cys Trp Ala Tyr Trp Ile Leu 
        115                 120                 125             


Pro Ile Ile Gly Ala Val Leu Leu Gly Phe Leu Tyr Arg Tyr Tyr Thr 
    130                 135                 140                 


Ser Glu Ser Lys Ser Ser 
145                 150 


<210>  162
<211>  146
<212>  PRT
<213>  Homo sapiens

<400>  162

Met Ala Thr Ala Glu Ala Ser Gly Ser Asp Gly Lys Gly Gln Glu Val 
1               5                   10                  15      


Glu Thr Ser Val Thr Tyr Tyr Arg Leu Glu Glu Val Ala Lys Arg Asn 
            20                  25                  30          


Ser Leu Lys Glu Leu Trp Leu Val Ile His Gly Arg Val Tyr Asp Val 
        35                  40                  45              


Thr Arg Phe Leu Asn Glu His Pro Gly Gly Glu Glu Val Leu Leu Glu 
    50                  55                  60                  


Gln Ala Gly Val Asp Ala Ser Glu Ser Phe Glu Asp Val Gly His Ser 
65                  70                  75                  80  


Ser Asp Ala Arg Glu Met Leu Lys Gln Tyr Tyr Ile Gly Asp Ile His 
                85                  90                  95      


Pro Ser Asp Leu Lys Pro Glu Ser Gly Ser Lys Asp Pro Ser Lys Asn 
            100                 105                 110         


Asp Thr Cys Lys Ser Cys Trp Ala Tyr Trp Ile Leu Pro Ile Ile Gly 
        115                 120                 125             


Ala Val Leu Leu Gly Phe Leu Tyr Arg Tyr Tyr Thr Ser Glu Ser Lys 
    130                 135                 140                 


Ser Ser 
145     


<210>  163
<211>  64
<212>  PRT
<213>  Homo sapiens

<400>  163

Lys Arg Asn Ser Leu Lys Glu Leu Trp Leu Val Ile His Gly Arg Val 
1               5                   10                  15      


Tyr Asp Val Thr Arg Phe Leu Asn Glu Asp Pro Ser Lys Asn Asp Thr 
            20                  25                  30          


Cys Lys Ser Cys Trp Ala Tyr Trp Ile Leu Pro Ile Ile Gly Ala Val 
        35                  40                  45              


Leu Leu Gly Phe Leu Tyr Arg Tyr Tyr Thr Ser Glu Ser Lys Ser Ser 
    50                  55                  60                  


<210>  164
<211>  317
<212>  PRT
<213>  Homo sapiens

<400>  164

Met Thr Ser Arg Thr Arg Val Thr Trp Pro Ser Pro Pro Arg Pro Leu 
1               5                   10                  15      


Pro Val Pro Ala Ala Ala Ala Val Ala Phe Gly Ala Lys Gly Thr Asp 
            20                  25                  30          


Pro Ala Glu Ala Arg Ser Ser Arg Gly Ile Glu Glu Ala Gly Pro Arg 
        35                  40                  45              


Ala His Gly Arg Ala Gly Arg Glu Pro Glu Arg Arg Arg Ser Arg Gln 
    50                  55                  60                  


Gln Arg Arg Gly Gly Leu Gln Ala Arg Arg Ser Thr Leu Leu Lys Thr 
65                  70                  75                  80  


Cys Ala Arg Ala Arg Ala Thr Ala Pro Gly Ala Met Lys Met Val Ala 
                85                  90                  95      


Pro Trp Thr Arg Phe Tyr Ser Asn Ser Cys Cys Leu Cys Cys His Val 
            100                 105                 110         


Arg Thr Gly Thr Ile Leu Leu Gly Val Trp Tyr Leu Ile Ile Asn Ala 
        115                 120                 125             


Val Val Leu Leu Ile Leu Leu Ser Ala Leu Ala Asp Pro Asp Gln Tyr 
    130                 135                 140                 


Asn Phe Ser Ser Ser Glu Leu Gly Gly Asp Phe Glu Phe Met Asp Asp 
145                 150                 155                 160 


Ala Asn Met Cys Ile Ala Ile Ala Ile Ser Leu Leu Met Ile Leu Ile 
                165                 170                 175     


Cys Ala Met Ala Thr Tyr Gly Ala Tyr Lys Gln Arg Ala Ala Trp Ile 
            180                 185                 190         


Ile Pro Phe Phe Cys Tyr Gln Ile Phe Asp Phe Ala Leu Asn Met Leu 
        195                 200                 205             


Val Ala Ile Thr Val Leu Ile Tyr Pro Asn Ser Ile Gln Glu Tyr Ile 
    210                 215                 220                 


Arg Gln Leu Pro Pro Asn Phe Pro Tyr Arg Asp Asp Val Met Ser Val 
225                 230                 235                 240 


Asn Pro Thr Cys Leu Val Leu Ile Ile Leu Leu Phe Ile Ser Ile Ile 
                245                 250                 255     


Leu Thr Phe Lys Gly Tyr Leu Ile Ser Cys Val Trp Asn Cys Tyr Arg 
            260                 265                 270         


Tyr Ile Asn Gly Arg Asn Ser Ser Asp Val Leu Val Tyr Val Thr Ser 
        275                 280                 285             


Asn Asp Thr Thr Val Leu Leu Pro Pro Tyr Asp Asp Ala Thr Val Asn 
    290                 295                 300                 


Gly Ala Ala Lys Glu Pro Pro Pro Pro Tyr Val Ser Ala 
305                 310                 315         


<210>  165
<211>  152
<212>  PRT
<213>  Homo sapiens

<400>  165

Met Lys Met Val Ala Pro Trp Thr Arg Phe Tyr Ser Asn Ser Cys Cys 
1               5                   10                  15      


Leu Cys Cys His Val Arg Thr Gly Thr Ile Leu Leu Gly Val Trp Tyr 
            20                  25                  30          


Leu Ile Ile Asn Ala Val Val Leu Leu Ile Leu Leu Ser Ala Leu Ala 
        35                  40                  45              


Asp Pro Asp Gln Tyr Asn Phe Ser Ser Ser Glu Leu Gly Gly Asp Phe 
    50                  55                  60                  


Glu Phe Met Asp Asp Ala Lys Ile Leu Phe Asn Leu Ser Ala Asp Met 
65                  70                  75                  80  


Cys Ile Ala Ile Ala Ile Ser Leu Leu Met Ile Leu Ile Cys Ala Met 
                85                  90                  95      


Ala Thr Tyr Gly Ala Tyr Lys Gln Arg Ala Ala Trp Ile Ile Pro Phe 
            100                 105                 110         


Phe Cys Tyr Gln Ile Phe Asp Phe Ala Leu Asn Met Leu Val Ala Ile 
        115                 120                 125             


Thr Val Leu Ile Tyr Pro Asn Ser Ile Gln Glu Tyr Ile Arg Gln Leu 
    130                 135                 140                 


Pro Pro Asn Phe Pro Tyr Arg Asp 
145                 150         


<210>  166
<211>  226
<212>  PRT
<213>  Homo sapiens

<400>  166

Met Lys Met Val Ala Pro Trp Thr Arg Phe Tyr Ser Asn Ser Cys Cys 
1               5                   10                  15      


Leu Cys Cys His Val Arg Thr Gly Thr Ile Leu Leu Gly Val Trp Tyr 
            20                  25                  30          


Leu Ile Ile Asn Ala Val Val Leu Leu Ile Leu Leu Ser Ala Leu Ala 
        35                  40                  45              


Asp Pro Asp Gln Tyr Asn Phe Ser Ser Ser Glu Leu Gly Gly Asp Phe 
    50                  55                  60                  


Glu Phe Met Asp Asp Ala Asn Met Cys Ile Ala Ile Ala Ile Ser Leu 
65                  70                  75                  80  


Leu Met Ile Leu Ile Cys Ala Met Ala Thr Tyr Gly Ala Tyr Lys Gln 
                85                  90                  95      


Arg Ala Ala Trp Ile Ile Pro Phe Phe Cys Tyr Gln Ile Phe Asp Phe 
            100                 105                 110         


Ala Leu Asn Met Leu Val Ala Ile Thr Val Leu Ile Tyr Pro Asn Ser 
        115                 120                 125             


Ile Gln Glu Tyr Ile Arg Gln Leu Pro Pro Asn Phe Pro Tyr Arg Asp 
    130                 135                 140                 


Asp Val Met Ser Val Asn Pro Thr Cys Leu Val Leu Ile Ile Leu Leu 
145                 150                 155                 160 


Phe Ile Ser Ile Ile Leu Thr Phe Lys Gly Tyr Leu Ile Ser Cys Val 
                165                 170                 175     


Trp Asn Cys Tyr Arg Tyr Ile Asn Gly Arg Asn Ser Ser Asp Val Leu 
            180                 185                 190         


Val Tyr Val Thr Ser Asn Asp Thr Thr Val Leu Leu Pro Pro Tyr Asp 
        195                 200                 205             


Asp Ala Thr Val Asn Gly Ala Ala Lys Glu Pro Pro Pro Pro Tyr Val 
    210                 215                 220                 


Ser Ala 
225     


<210>  167
<211>  317
<212>  PRT
<213>  Homo sapiens

<400>  167

Met Thr Ser Arg Thr Arg Val Thr Trp Pro Ser Pro Pro Arg Pro Leu 
1               5                   10                  15      


Pro Val Pro Ala Ala Ala Ala Val Ala Phe Gly Ala Lys Gly Thr Asp 
            20                  25                  30          


Pro Ala Glu Ala Arg Ser Ser Arg Gly Ile Glu Glu Ala Gly Pro Arg 
        35                  40                  45              


Ala His Gly Arg Ala Gly Arg Glu Pro Glu Arg Arg Arg Ser Arg Gln 
    50                  55                  60                  


Gln Arg Arg Gly Gly Leu Gln Ala Arg Arg Ser Thr Leu Leu Lys Thr 
65                  70                  75                  80  


Cys Ala Arg Ala Arg Ala Thr Ala Pro Gly Ala Met Lys Met Val Ala 
                85                  90                  95      


Pro Trp Thr Arg Phe Tyr Ser Asn Ser Cys Cys Leu Cys Cys His Val 
            100                 105                 110         


Arg Thr Gly Thr Ile Leu Leu Gly Val Trp Tyr Leu Ile Ile Asn Ala 
        115                 120                 125             


Val Val Leu Leu Ile Leu Leu Ser Ala Leu Ala Asp Pro Asp Gln Tyr 
    130                 135                 140                 


Asn Phe Ser Ser Ser Glu Leu Gly Gly Asp Phe Glu Phe Met Asp Asp 
145                 150                 155                 160 


Ala Asn Met Cys Ile Ala Ile Ala Ile Ser Leu Leu Met Ile Leu Ile 
                165                 170                 175     


Cys Ala Met Ala Thr Tyr Gly Ala Tyr Lys Gln Arg Ala Ala Trp Ile 
            180                 185                 190         


Ile Pro Phe Phe Cys Tyr Gln Ile Phe Asp Phe Ala Leu Asn Met Leu 
        195                 200                 205             


Val Ala Ile Thr Val Leu Ile Tyr Pro Asn Ser Ile Gln Glu Tyr Ile 
    210                 215                 220                 


Arg Gln Leu Pro Pro Asn Phe Pro Tyr Arg Asp Asp Val Met Ser Val 
225                 230                 235                 240 


Asn Pro Thr Cys Leu Val Leu Ile Ile Leu Leu Phe Ile Ser Ile Ile 
                245                 250                 255     


Leu Thr Phe Lys Gly Tyr Leu Ile Ser Cys Val Trp Asn Cys Tyr Arg 
            260                 265                 270         


Tyr Ile Asn Gly Arg Asn Ser Ser Asp Val Leu Val Tyr Val Thr Ser 
        275                 280                 285             


Asn Asp Thr Thr Val Leu Leu Pro Pro Tyr Asp Asp Ala Thr Val Asn 
    290                 295                 300                 


Gly Ala Ala Lys Glu Pro Pro Pro Pro Tyr Val Ser Ala 
305                 310                 315         


<210>  168
<211>  177
<212>  PRT
<213>  Homo sapiens

<400>  168

Met Phe His Val Ser Phe Arg Tyr Ile Phe Gly Leu Pro Pro Leu Ile 
1               5                   10                  15      


Leu Val Leu Leu Pro Val Ala Ser Ser Asp Cys Asp Ile Glu Gly Lys 
            20                  25                  30          


Asp Gly Lys Gln Tyr Glu Ser Val Leu Met Val Ser Ile Asp Gln Leu 
        35                  40                  45              


Leu Asp Ser Met Lys Glu Ile Gly Ser Asn Cys Leu Asn Asn Glu Phe 
    50                  55                  60                  


Asn Phe Phe Lys Arg His Ile Cys Asp Ala Asn Lys Glu Gly Met Phe 
65                  70                  75                  80  


Leu Phe Arg Ala Ala Arg Lys Leu Arg Gln Phe Leu Lys Met Asn Ser 
                85                  90                  95      


Thr Gly Asp Phe Asp Leu His Leu Leu Lys Val Ser Glu Gly Thr Thr 
            100                 105                 110         


Ile Leu Leu Asn Cys Thr Gly Gln Val Lys Gly Arg Lys Pro Ala Ala 
        115                 120                 125             


Leu Gly Glu Ala Gln Pro Thr Lys Ser Leu Glu Glu Asn Lys Ser Leu 
    130                 135                 140                 


Lys Glu Gln Lys Lys Leu Asn Asp Leu Cys Phe Leu Lys Arg Leu Leu 
145                 150                 155                 160 


Gln Glu Ile Lys Thr Cys Trp Asn Lys Ile Leu Met Gly Thr Lys Glu 
                165                 170                 175     


His 
    


<210>  169
<211>  115
<212>  PRT
<213>  Homo sapiens

<400>  169

Met Phe His Val Ser Phe Arg Tyr Ile Phe Gly Leu Pro Pro Leu Ile 
1               5                   10                  15      


Leu Val Leu Leu Pro Val Ala Ser Ser Asp Cys Asp Ile Glu Gly Lys 
            20                  25                  30          


Asp Gly Lys Gln Tyr Glu Ser Val Leu Met Val Ser Ile Asp Gln Leu 
        35                  40                  45              


Leu Asp Ser Met Lys Glu Ile Gly Ser Asn Cys Leu Asn Asn Glu Phe 
    50                  55                  60                  


Asn Phe Phe Lys Arg His Ile Cys Asp Ala Asn Lys Glu Glu Asn Lys 
65                  70                  75                  80  


Ser Leu Lys Glu Gln Lys Lys Leu Asn Asp Leu Cys Phe Leu Lys Arg 
                85                  90                  95      


Leu Leu Gln Glu Ile Lys Thr Cys Trp Asn Lys Ile Leu Met Gly Thr 
            100                 105                 110         


Lys Glu His 
        115 


<210>  170
<211>  71
<212>  PRT
<213>  Homo sapiens

<400>  170

Met Phe His Val Ser Phe Arg Tyr Ile Phe Gly Leu Pro Pro Leu Ile 
1               5                   10                  15      


Leu Val Leu Leu Pro Val Ala Ser Ser Asp Cys Asp Ile Glu Gly Lys 
            20                  25                  30          


Asp Gly Lys Gln Tyr Glu Ser Val Leu Met Val Ser Ile Asp Gln Leu 
        35                  40                  45              


Leu Asn Gln Pro Tyr Lys Lys Lys Glu Lys Arg Thr Glu Arg Lys Gln 
    50                  55                  60                  


Gln Ser Ala Met Ser Asn Asn 
65                  70      


<210>  171
<211>  37
<212>  PRT
<213>  Homo sapiens

<400>  171

Met Phe His Val Ser Phe Arg Tyr Ile Phe Gly Leu Pro Pro Leu Ile 
1               5                   10                  15      


Leu Val Leu Leu Pro Val Ala Ser Ser Asp Cys Asp Ile Glu Gly Gln 
            20                  25                  30          


His Glu Arg Asn Trp 
        35          


<210>  172
<211>  133
<212>  PRT
<213>  Homo sapiens

<400>  172

Met Phe His Val Ser Phe Arg Tyr Ile Phe Gly Leu Pro Pro Leu Ile 
1               5                   10                  15      


Leu Val Leu Leu Pro Val Ala Ser Ser Asp Cys Asp Ile Glu Gly Lys 
            20                  25                  30          


Asp Gly Lys Gln Tyr Glu Ser Val Leu Met Val Ser Ile Asp Gln Leu 
        35                  40                  45              


Leu Asp Ser Met Lys Glu Ile Gly Ser Asn Cys Leu Asn Asn Glu Phe 
    50                  55                  60                  


Asn Phe Phe Lys Arg His Ile Cys Asp Ala Asn Lys Val Lys Gly Arg 
65                  70                  75                  80  


Lys Pro Ala Ala Leu Gly Glu Ala Gln Pro Thr Lys Ser Leu Glu Glu 
                85                  90                  95      


Asn Lys Ser Leu Lys Glu Gln Lys Lys Leu Asn Asp Leu Cys Phe Leu 
            100                 105                 110         


Lys Arg Leu Leu Gln Glu Ile Lys Thr Cys Trp Asn Lys Ile Leu Met 
        115                 120                 125             


Gly Thr Lys Glu His 
    130             


<210>  173
<211>  37
<212>  PRT
<213>  Homo sapiens

<400>  173

Met Phe His Val Ser Phe Arg Tyr Ile Phe Gly Leu Pro Pro Leu Ile 
1               5                   10                  15      


Leu Val Leu Leu Pro Val Ala Ser Ser Asp Cys Asp Ile Glu Gly Gln 
            20                  25                  30          


His Glu Arg Asn Trp 
        35          


<210>  174
<211>  159
<212>  PRT
<213>  Homo sapiens

<400>  174

Met Phe His Val Ser Phe Arg Tyr Ile Phe Gly Leu Pro Pro Leu Ile 
1               5                   10                  15      


Leu Val Leu Leu Pro Val Ala Ser Ser Asp Cys Asp Ile Glu Gly Lys 
            20                  25                  30          


Asp Gly Lys Gln Tyr Glu Ser Val Leu Met Val Ser Ile Asp Gln Leu 
        35                  40                  45              


Leu Asp Ser Met Lys Glu Ile Gly Ser Asn Cys Leu Asn Asn Glu Phe 
    50                  55                  60                  


Asn Phe Phe Lys Arg His Ile Cys Asp Ala Asn Lys Glu Gly Met Phe 
65                  70                  75                  80  


Leu Phe Arg Ala Ala Arg Lys Leu Arg Gln Phe Leu Lys Met Asn Ser 
                85                  90                  95      


Thr Gly Asp Phe Asp Leu His Leu Leu Lys Val Ser Glu Gly Thr Thr 
            100                 105                 110         


Ile Leu Leu Asn Cys Thr Gly Gln Glu Glu Asn Lys Ser Leu Lys Glu 
        115                 120                 125             


Gln Lys Lys Leu Asn Asp Leu Cys Phe Leu Lys Arg Leu Leu Gln Glu 
    130                 135                 140                 


Ile Lys Thr Cys Trp Asn Lys Ile Leu Met Gly Thr Lys Glu His 
145                 150                 155                 


<210>  175
<211>  229
<212>  PRT
<213>  Homo sapiens

<400>  175

Met Thr Pro Gln Leu Leu Leu Ala Leu Val Leu Trp Ala Ser Cys Pro 
1               5                   10                  15      


Pro Cys Ser Gly Arg Lys Gly Pro Pro Ala Ala Leu Thr Leu Pro Arg 
            20                  25                  30          


Val Gln Cys Arg Ala Ser Arg Tyr Pro Ile Ala Val Asp Cys Ser Trp 
        35                  40                  45              


Thr Leu Pro Pro Ala Pro Asn Ser Thr Ser Pro Val Ser Phe Ile Ala 
    50                  55                  60                  


Thr Tyr Arg Leu Gly Met Ala Ala Arg Gly His Ser Trp Pro Cys Leu 
65                  70                  75                  80  


Gln Gln Thr Pro Thr Ser Thr Ser Cys Thr Ile Thr Asp Val Gln Leu 
                85                  90                  95      


Phe Ser Met Ala Pro Tyr Val Leu Asn Val Thr Ala Val His Pro Trp 
            100                 105                 110         


Gly Ser Ser Ser Ser Phe Val Pro Phe Ile Thr Glu His Ile Ile Lys 
        115                 120                 125             


Pro Asp Pro Pro Glu Gly Val Arg Leu Ser Pro Leu Ala Glu Arg Gln 
    130                 135                 140                 


Leu Gln Val Gln Trp Glu Pro Pro Gly Ser Trp Pro Phe Pro Glu Ile 
145                 150                 155                 160 


Phe Ser Leu Lys Tyr Trp Ile Arg Tyr Lys Arg Gln Gly Ala Ala Arg 
                165                 170                 175     


Phe His Arg Val Gly Pro Ile Glu Ala Thr Ser Phe Ile Leu Arg Ala 
            180                 185                 190         


Val Arg Pro Arg Ala Arg Tyr Tyr Val Gln Val Ala Ala Gln Asp Leu 
        195                 200                 205             


Thr Asp Tyr Gly Glu Leu Ser Asp Trp Ser Leu Pro Ala Thr Ala Thr 
    210                 215                 220                 


Met Ser Leu Gly Lys 
225                 


<210>  176
<211>  130
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  176

Xaa Met Leu Glu Asn Trp Thr Arg Thr Ser Leu Glu Lys Gln Glu Gln 
1               5                   10                  15      


Pro His Glu Asp Pro Glu Arg Lys Gly Ser Leu Ser Asn Leu Met Asp 
            20                  25                  30          


Phe Val Lys Lys Thr Gly Ile Cys Ala Ser Lys Trp Glu Trp Gly Thr 
        35                  40                  45              


Thr His Asn Phe Leu Tyr Lys His Gly Gly Ile Arg Asp Lys Ile Met 
    50                  55                  60                  


Ser Ser Arg Lys His Leu His Leu Val Asp Ala Gly Leu Ala Ile Asn 
65                  70                  75                  80  


Thr Pro Phe Pro Leu Val Leu Pro Pro Thr Arg Glu Val His Leu Ile 
                85                  90                  95      


Leu Ser Phe Asp Phe Ser Ala Gly Asp Pro Phe Glu His Pro Arg Ser 
            100                 105                 110         


Ala Thr Ser Asn Glu Leu Leu Cys Met Ser Val Ser Ser Ala Val Lys 
        115                 120                 125             


Leu Gly 
    130 


<210>  177
<211>  36
<212>  PRT
<213>  Homo sapiens

<400>  177

Met Arg Thr Arg Pro Arg Pro Arg Leu Arg Leu Glu Cys Asn Gly Met 
1               5                   10                  15      


Ile Ser Ala His Trp His Leu His Leu Leu Ser Ser Ser Asp Ser Pro 
            20                  25                  30          


Pro Ser Ala Ser 
        35      


<210>  178
<211>  47
<212>  PRT
<213>  Homo sapiens

<400>  178

Met Lys Glu Gln Gly Leu Leu Asp Ala Val Thr Tyr Leu Ala Gly Val 
1               5                   10                  15      


Ser Gly Ser Thr Trp Ala Ile Ser Ser Leu Tyr Thr Asn Asp Gly Asp 
            20                  25                  30          


Met Glu Ala Leu Glu Ala Asp Leu Lys His Arg Phe Thr Arg Gln 
        35                  40                  45          


<210>  179
<211>  43
<212>  PRT
<213>  Homo sapiens

<400>  179

Met Arg Thr Arg Pro Arg Pro Arg Leu Arg Val Ser Leu Leu Leu Pro 
1               5                   10                  15      


Arg Leu Glu Cys Asn Gly Met Ile Ser Ala His Trp His Leu His Leu 
            20                  25                  30          


Leu Ser Ser Ser Asp Ser Pro Pro Ser Ala Ser 
        35                  40              


<210>  180
<211>  194
<212>  PRT
<213>  Homo sapiens

<400>  180

Ala Ala Ala Ala Pro Ala Glu Gln Ala Pro Arg Ala Lys Gly Arg Pro 
1               5                   10                  15      


Arg Arg Ser Pro Glu Ser His Arg Arg Ser Ser Ser Pro Glu Arg Arg 
            20                  25                  30          


Ser Pro Gly Ser Pro Val Cys Arg Ala Asp Lys Ala Lys Ser Gln Gln 
        35                  40                  45              


Val Arg Thr Ser Ser Thr Ile Arg Arg Thr Ser Ser Leu Asp Thr Ile 
    50                  55                  60                  


Thr Gly Pro Tyr Leu Thr Gly Gln Trp Pro Arg Asp Pro His Val His 
65                  70                  75                  80  


Tyr Pro Ser Cys Met Lys Asp Lys Ala Thr Gln Thr Pro Ser Cys Trp 
                85                  90                  95      


Ala Glu Glu Gly Ala Glu Lys Arg Ser His Gln Arg Ser Ala Ser Trp 
            100                 105                 110         


Gly Ser Ala Asp Gln Leu Lys Glu Gln Ile Ala Lys Leu Arg Gln Gln 
        115                 120                 125             


Leu Gln Arg Ser Lys Gln Ser Ser Arg His Ser Lys Glu Lys Asp Arg 
    130                 135                 140                 


Gln Ser Pro Leu His Gly Asn His Ile Thr Ile Ser His Thr Gln Ala 
145                 150                 155                 160 


Thr Gly Ser Ser Arg Trp Thr Tyr Gln Met Val Glu Glu Leu His Phe 
                165                 170                 175     


Leu Leu Ile Thr Gly Ala Val Val Leu Ala Ala Leu Thr Leu Arg Leu 
            180                 185                 190         


Leu Leu 
        


<210>  181
<211>  312
<212>  PRT
<213>  Homo sapiens

<400>  181

Met Leu Arg Ala Pro Gly Cys Leu Leu Arg Thr Ser Val Ala Pro Ala 
1               5                   10                  15      


Ala Ala Leu Ala Ala Ala Leu Leu Ser Ser Leu Ala Arg Cys Ser Leu 
            20                  25                  30          


Leu Glu Pro Arg Asp Pro Val Ala Ser Ser Leu Ser Pro Tyr Phe Gly 
        35                  40                  45              


Thr Lys Thr Arg Tyr Glu Asp Val Asn Pro Val Leu Leu Ser Gly Pro 
    50                  55                  60                  


Glu Ala Pro Trp Arg Asp Pro Glu Leu Leu Glu Gly Thr Cys Thr Pro 
65                  70                  75                  80  


Val Gln Leu Val Ala Leu Ile Arg His Gly Thr Arg Tyr Pro Thr Val 
                85                  90                  95      


Lys Gln Ile Arg Lys Leu Arg Gln Leu His Gly Leu Leu Gln Ala Arg 
            100                 105                 110         


Gly Ser Arg Asp Gly Gly Ala Ser Ser Thr Gly Ser Arg Asp Leu Gly 
        115                 120                 125             


Ala Ala Leu Ala Asp Trp Pro Leu Trp Tyr Ala Asp Trp Met Asp Gly 
    130                 135                 140                 


Gln Leu Val Glu Lys Gly Arg Gln Asp Met Arg Gln Leu Ala Leu Arg 
145                 150                 155                 160 


Leu Ala Ser Leu Phe Pro Ala Leu Phe Ser Arg Glu Asn Tyr Gly Arg 
                165                 170                 175     


Leu Arg Leu Ile Thr Ser Ser Lys His Arg Cys Met Asp Ser Ser Ala 
            180                 185                 190         


Ala Phe Leu Gln Gly Leu Trp Gln His Tyr His Pro Gly Leu Pro Pro 
        195                 200                 205             


Pro Asp Val Ala Asp Met Glu Phe Gly Pro Pro Thr Val Asn Asp Lys 
    210                 215                 220                 


Leu Met Arg Phe Phe Asp His Cys Glu Lys Phe Leu Thr Glu Val Glu 
225                 230                 235                 240 


Lys Asn Ala Thr Ala Leu Tyr His Val Glu Ala Phe Lys Thr Gly Pro 
                245                 250                 255     


Glu Met Gln Asn Ile Leu Lys Lys Val Ala Ala Thr Leu Gln Val Pro 
            260                 265                 270         


Val Asn Asp Leu Asn Ala Gly Leu Ser Gln Phe Leu Leu Gln Ser Ser 
        275                 280                 285             


Ser Ser Leu Val Met Gln Arg Leu Phe Phe His Cys Phe Leu Ser Trp 
    290                 295                 300                 


Ala Thr Ser Lys Thr Arg Asn Pro 
305                 310         


<210>  182
<211>  487
<212>  PRT
<213>  Homo sapiens

<400>  182

Met Leu Arg Ala Pro Gly Cys Leu Leu Arg Thr Ser Val Ala Pro Ala 
1               5                   10                  15      


Ala Ala Leu Ala Ala Ala Leu Leu Ser Ser Leu Ala Arg Cys Ser Leu 
            20                  25                  30          


Leu Glu Pro Arg Asp Pro Val Ala Ser Ser Leu Ser Pro Tyr Phe Gly 
        35                  40                  45              


Thr Lys Thr Arg Tyr Glu Asp Val Asn Pro Val Leu Leu Ser Gly Pro 
    50                  55                  60                  


Glu Ala Pro Trp Arg Asp Pro Glu Leu Leu Glu Gly Thr Cys Thr Pro 
65                  70                  75                  80  


Val Gln Leu Val Ala Leu Ile Arg His Gly Thr Arg Tyr Pro Thr Val 
                85                  90                  95      


Lys Gln Ile Arg Lys Leu Arg Gln Leu His Gly Leu Leu Gln Ala Arg 
            100                 105                 110         


Gly Ser Arg Asp Gly Gly Ala Ser Ser Thr Gly Ser Arg Asp Leu Gly 
        115                 120                 125             


Ala Ala Leu Ala Asp Trp Pro Leu Trp Tyr Ala Asp Trp Met Asp Gly 
    130                 135                 140                 


Gln Leu Val Glu Lys Gly Arg Gln Asp Met Arg Gln Leu Ala Leu Arg 
145                 150                 155                 160 


Leu Ala Ser Leu Phe Pro Ala Leu Phe Ser Arg Glu Asn Tyr Gly Arg 
                165                 170                 175     


Leu Arg Leu Ile Thr Ser Ser Lys His Arg Cys Met Asp Ser Ser Ala 
            180                 185                 190         


Ala Phe Leu Gln Gly Leu Trp Gln His Tyr His Pro Gly Leu Pro Pro 
        195                 200                 205             


Pro Asp Val Ala Asp Met Glu Phe Gly Pro Pro Thr Val Asn Asp Lys 
    210                 215                 220                 


Leu Met Arg Phe Phe Asp His Cys Glu Lys Phe Leu Thr Glu Val Glu 
225                 230                 235                 240 


Lys Asn Ala Thr Ala Leu Tyr His Val Glu Ala Phe Lys Thr Gly Pro 
                245                 250                 255     


Glu Met Gln Asn Ile Leu Lys Lys Val Ala Ala Thr Leu Gln Val Pro 
            260                 265                 270         


Val Asn Asp Leu Asn Ala Asp Leu Ile Gln Val Ala Phe Phe Thr Cys 
        275                 280                 285             


Ser Phe Asp Leu Ala Ile Lys Gly Val Lys Ser Pro Trp Cys Asp Val 
    290                 295                 300                 


Phe Asp Ile Asp Asp Ala Lys Val Leu Glu Tyr Leu Asn Asp Leu Lys 
305                 310                 315                 320 


Gln Tyr Trp Lys Arg Gly Tyr Gly Tyr Thr Ile Asn Ser Arg Ser Ser 
                325                 330                 335     


Cys Thr Leu Phe Gln Asp Ile Phe Gln His Leu Asp Lys Ala Val Glu 
            340                 345                 350         


Gln Lys Gln Arg Ser Gln Pro Ile Ser Ser Pro Val Ile Leu Gln Phe 
        355                 360                 365             


Gly His Ala Glu Thr Leu Leu Pro Leu Leu Ser Leu Met Gly Tyr Phe 
    370                 375                 380                 


Lys Asp Lys Glu Pro Leu Thr Ala Tyr Asn Tyr Lys Lys Gln Met His 
385                 390                 395                 400 


Arg Lys Phe Arg Ser Gly Leu Ile Val Pro Tyr Ala Ser Asn Leu Ile 
                405                 410                 415     


Phe Val Leu Tyr His Cys Glu Asn Ala Lys Thr Pro Lys Glu Gln Phe 
            420                 425                 430         


Arg Val Gln Met Leu Leu Asn Glu Lys Val Leu Pro Leu Ala Tyr Ser 
        435                 440                 445             


Gln Glu Thr Val Ser Phe Tyr Glu Asp Leu Lys Asn His Tyr Lys Asp 
    450                 455                 460                 


Ile Leu Gln Ser Cys Gln Thr Ser Glu Glu Cys Glu Leu Ala Arg Ala 
465                 470                 475                 480 


Asn Ser Thr Ser Asp Glu Leu 
                485         


<210>  183
<211>  286
<212>  PRT
<213>  Homo sapiens

<400>  183

Met Cys Leu Phe Gln Leu Cys Gly Leu Val Arg Tyr Met Glu Phe Gly 
1               5                   10                  15      


Pro Pro Thr Val Asn Asp Lys Leu Met Arg Phe Phe Asp His Cys Glu 
            20                  25                  30          


Lys Phe Leu Thr Glu Val Glu Lys Asn Ala Thr Ala Leu Tyr His Val 
        35                  40                  45              


Glu Ala Phe Lys Thr Gly Pro Glu Met Gln Asn Ile Leu Lys Lys Val 
    50                  55                  60                  


Ala Ala Thr Leu Gln Val Pro Val Asn Asp Leu Asn Ala Asp Leu Ile 
65                  70                  75                  80  


Gln Val Ala Phe Phe Thr Cys Ser Phe Asp Leu Ala Ile Lys Gly Val 
                85                  90                  95      


Lys Ser Pro Trp Cys Asp Val Phe Asp Ile Asp Asp Ala Lys Val Leu 
            100                 105                 110         


Glu Tyr Leu Asn Asp Leu Lys Gln Tyr Trp Lys Arg Gly Tyr Gly Tyr 
        115                 120                 125             


Thr Ile Asn Ser Arg Ser Ser Cys Thr Leu Phe Gln Asp Ile Phe Gln 
    130                 135                 140                 


His Leu Asp Lys Ala Val Glu Gln Lys Gln Arg Ser Gln Pro Ile Ser 
145                 150                 155                 160 


Ser Pro Val Ile Leu Gln Phe Gly His Ala Glu Thr Leu Leu Pro Leu 
                165                 170                 175     


Leu Ser Leu Met Gly Tyr Phe Lys Asp Lys Glu Pro Leu Thr Ala Tyr 
            180                 185                 190         


Asn Tyr Lys Lys Gln Met His Arg Lys Phe Arg Ser Gly Leu Ile Val 
        195                 200                 205             


Pro Tyr Ala Ser Asn Leu Ile Phe Val Leu Tyr His Cys Glu Asn Ala 
    210                 215                 220                 


Lys Thr Pro Lys Glu Gln Phe Arg Val Gln Met Leu Leu Asn Glu Lys 
225                 230                 235                 240 


Val Leu Pro Leu Ala Tyr Ser Gln Glu Thr Val Ser Phe Tyr Glu Asp 
                245                 250                 255     


Leu Lys Asn His Tyr Lys Asp Ile Leu Gln Ser Cys Gln Thr Ser Glu 
            260                 265                 270         


Glu Cys Glu Leu Ala Arg Ala Asn Ser Thr Ser Asp Glu Leu 
        275                 280                 285     


<210>  184
<211>  207
<212>  PRT
<213>  Homo sapiens

<400>  184

Met Ala Ser Phe Pro Pro Arg Val Asn Glu Lys Glu Ile Val Phe Leu 
1               5                   10                  15      


Phe Phe Leu Leu Val Arg Leu Arg Thr Ile Gly Glu Leu Leu Ala Pro 
            20                  25                  30          


Ala Ala Pro Phe Asp Lys Lys Cys Gly Arg Glu Asn Trp Thr Val Ala 
        35                  40                  45              


Phe Ala Pro Asp Gly Ser Tyr Phe Ala Trp Ser Gln Gly His Arg Thr 
    50                  55                  60                  


Val Lys Leu Val Pro Trp Ser Gln Cys Leu Gln Asn Phe Leu Leu His 
65                  70                  75                  80  


Gly Thr Lys Asn Val Thr Asn Ser Ser Ser Leu Arg Leu Pro Arg Gln 
                85                  90                  95      


Asn Ser Asp Gly Gly Gln Lys Asn Lys Pro Arg Glu His Ile Ile Asp 
            100                 105                 110         


Cys Gly Asp Ile Val Trp Ser Leu Ala Phe Gly Ser Ser Val Pro Glu 
        115                 120                 125             


Lys Gln Ser Arg Cys Val Asn Ile Glu Trp His Arg Phe Arg Phe Gly 
    130                 135                 140                 


Gln Asp Gln Leu Leu Leu Ala Thr Gly Leu Asn Asn Gly Arg Ile Lys 
145                 150                 155                 160 


Ile Trp Asp Val Tyr Thr Gly Lys Leu Leu Leu Asn Leu Val Asp His 
                165                 170                 175     


Thr Glu Val Val Arg Asp Leu Thr Phe Ala Pro Asp Gly Ser Leu Ile 
            180                 185                 190         


Leu Val Ser Ala Ser Arg Asp Lys Thr Leu Arg Val Trp Asp Leu 
        195                 200                 205         


<210>  185
<211>  74
<212>  PRT
<213>  Homo sapiens

<400>  185

Met Ala Ser Phe Pro Pro Arg Val Asn Glu Lys Glu Ile Val Arg Leu 
1               5                   10                  15      


Arg Thr Ile Gly Glu Leu Leu Ala Pro Ala Ala Pro Phe Asp Lys Lys 
            20                  25                  30          


Cys Gly Arg Glu Asn Trp Thr Val Ala Phe Ala Pro Asp Gly Ser Tyr 
        35                  40                  45              


Phe Ala Trp Ser Gln Gly His Arg Thr Val Lys Leu Val Pro Trp Ser 
    50                  55                  60                  


Gln Cys Leu Gln Asn Leu Lys Thr Pro Pro 
65                  70                  


<210>  186
<211>  54
<212>  PRT
<213>  Homo sapiens

<400>  186

Met Ala Ser Phe Pro Pro Arg Val Asn Glu Lys Glu Ile Gly Asn Met 
1               5                   10                  15      


Met Lys Val Leu Arg Gly His Gln Asn Trp Val Tyr Ser Cys Ala Phe 
            20                  25                  30          


Ser Pro Asp Ser Ser Met Leu Cys Ser Val Gly Ala Ser Lys Ala Val 
        35                  40                  45              


Val Ala Ala Ile Leu Val 
    50                  


<210>  187
<211>  78
<212>  PRT
<213>  Homo sapiens

<400>  187

Met Ala Ser Phe Pro Pro Arg Val Asn Glu Lys Glu Ile Ala Pro Ala 
1               5                   10                  15      


Ala Pro Phe Asp Lys Lys Cys Gly Arg Glu Asn Trp Thr Val Ala Phe 
            20                  25                  30          


Ala Pro Asp Gly Ser Tyr Phe Ala Trp Ser Gln Gly His Arg Thr Val 
        35                  40                  45              


Lys Leu Val Pro Trp Ser Gln Cys Leu Gln Asn Phe Leu Leu His Gly 
    50                  55                  60                  


Thr Lys Asn Val Thr Asn Ser Ser Ser Leu Arg Leu Pro Arg 
65                  70                  75              


<210>  188
<211>  276
<212>  PRT
<213>  Homo sapiens

<400>  188

Met Ala Gly Pro Ala Ala Leu Ser Ala Ala Ala Ala Ala Ala Leu Ala 
1               5                   10                  15      


Ala Ala Leu Leu Leu Leu Arg Arg Glu Asp Pro Gly Pro Gly Ala Gly 
            20                  25                  30          


Pro Ser Met Ala Glu Thr Glu Ala Leu Ser Lys Leu Arg Glu Asp Phe 
        35                  40                  45              


Arg Met Gln Asn Lys Ser Val Phe Ile Leu Gly Ala Ser Gly Glu Thr 
    50                  55                  60                  


Gly Arg Val Leu Leu Lys Glu Ile Leu Glu Gln Gly Leu Phe Ser Lys 
65                  70                  75                  80  


Val Thr Leu Ile Gly Arg Arg Lys Leu Thr Phe Asp Glu Glu Ala Tyr 
                85                  90                  95      


Lys Asn Val Asn Gln Glu Val Val Asp Phe Glu Lys Leu Asp Asp Tyr 
            100                 105                 110         


Ala Ser Ala Phe Gln Gly His Asp Val Gly Phe Cys Cys Leu Gly Thr 
        115                 120                 125             


Thr Arg Gly Lys Ala Gly Ala Glu Gly Phe Val Arg Val Asp Arg Asp 
    130                 135                 140                 


Tyr Val Leu Lys Ser Ala Glu Leu Ala Lys Ala Gly Gly Cys Lys His 
145                 150                 155                 160 


Phe Asn Leu Leu Ser Ser Lys Gly Ala Asp Lys Ser Ser Asn Phe Leu 
                165                 170                 175     


Tyr Leu Gln Val Lys Gly Glu Val Glu Ala Lys Val Glu Glu Leu Lys 
            180                 185                 190         


Phe Asp Arg Tyr Ser Val Phe Arg Pro Gly Val Leu Leu Cys Asp Arg 
        195                 200                 205             


Gln Glu Ser Arg Pro Gly Glu Trp Leu Val Arg Lys Phe Phe Gly Ser 
    210                 215                 220                 


Leu Pro Asp Ser Trp Ala Ser Gly His Ser Val Pro Val Val Thr Val 
225                 230                 235                 240 


Val Arg Ala Met Leu Asn Asn Val Val Arg Pro Arg Asp Lys Gln Met 
                245                 250                 255     


Glu Leu Leu Glu Asn Lys Ala Ile His Asp Leu Gly Lys Ala His Gly 
            260                 265                 270         


Ser Leu Lys Pro 
        275     


<210>  189
<211>  133
<212>  PRT
<213>  Homo sapiens

<400>  189

Met Ala Glu Thr Glu Ala Leu Ser Lys Leu Arg Glu Asp Phe Arg Met 
1               5                   10                  15      


Gln Asn Lys Ser Val Phe Ile Leu Gly Ala Ser Gly Glu Thr Gly Arg 
            20                  25                  30          


Val Leu Leu Lys Glu Ile Leu Glu Gln Gly Leu Phe Ser Lys Val Thr 
        35                  40                  45              


Leu Ile Gly Arg Arg Lys Leu Thr Phe Asp Glu Glu Ala Tyr Lys Asn 
    50                  55                  60                  


Val Asn Gln Glu Val Val Asp Phe Glu Lys Leu Asp Asp Tyr Ala Ser 
65                  70                  75                  80  


Ala Phe Gln Gly His Asp Val Gly Phe Cys Cys Leu Gly Thr Thr Arg 
                85                  90                  95      


Gly Lys Ala Gly Ala Val Arg Lys Ala Tyr Ala Leu Phe Pro Phe Cys 
            100                 105                 110         


Trp Pro Val Ile Ser Arg Ile Leu Phe Leu Leu Thr Leu Phe Leu Cys 
        115                 120                 125             


Ala Cys Cys Asn Ala 
    130             


<210>  190
<211>  133
<212>  PRT
<213>  Homo sapiens

<400>  190

Met Ala Glu Thr Glu Ala Leu Ser Lys Leu Arg Glu Asp Phe Arg Met 
1               5                   10                  15      


Gln Asn Lys Ser Val Phe Ile Leu Gly Ala Ser Gly Glu Thr Gly Arg 
            20                  25                  30          


Val Leu Leu Lys Glu Ile Leu Glu Gln Gly Leu Phe Ser Lys Val Thr 
        35                  40                  45              


Leu Ile Gly Arg Arg Lys Leu Thr Phe Asp Glu Glu Ala Tyr Lys Asn 
    50                  55                  60                  


Val Asn Gln Glu Val Val Asp Phe Glu Lys Leu Asp Asp Tyr Ala Ser 
65                  70                  75                  80  


Ala Phe Gln Gly His Asp Val Gly Phe Cys Cys Leu Gly Thr Thr Arg 
                85                  90                  95      


Gly Lys Ala Gly Ala Val Arg Lys Ala Tyr Ala Leu Phe Pro Phe Cys 
            100                 105                 110         


Trp Pro Val Ile Ser Arg Ile Leu Phe Leu Leu Thr Leu Phe Leu Cys 
        115                 120                 125             


Ala Cys Cys Asn Ala 
    130             


<210>  191
<211>  133
<212>  PRT
<213>  Homo sapiens

<400>  191

Met Ala Glu Thr Glu Ala Leu Ser Lys Leu Arg Glu Asp Phe Arg Met 
1               5                   10                  15      


Gln Asn Lys Ser Val Phe Ile Leu Gly Ala Ser Gly Glu Thr Gly Arg 
            20                  25                  30          


Val Leu Leu Lys Glu Ile Leu Glu Gln Gly Leu Phe Ser Lys Val Thr 
        35                  40                  45              


Leu Ile Gly Arg Arg Lys Leu Thr Phe Asp Glu Glu Ala Tyr Lys Asn 
    50                  55                  60                  


Val Asn Gln Glu Val Val Asp Phe Glu Lys Leu Asp Asp Tyr Ala Ser 
65                  70                  75                  80  


Ala Phe Gln Gly His Asp Val Gly Phe Cys Cys Leu Gly Thr Thr Arg 
                85                  90                  95      


Gly Lys Ala Gly Ala Val Arg Lys Ala Tyr Ala Leu Phe Pro Phe Cys 
            100                 105                 110         


Trp Pro Val Ile Ser Arg Ile Leu Phe Leu Leu Thr Leu Phe Leu Cys 
        115                 120                 125             


Ala Cys Cys Asn Ala 
    130             


<210>  192
<211>  463
<212>  PRT
<213>  Homo sapiens

<400>  192

Met Gly Ala Gly Pro Ser Leu Leu Leu Ala Ala Leu Leu Leu Leu Leu 
1               5                   10                  15      


Ser Gly Asp Gly Ala Val Arg Cys Asp Thr Pro Ala Asn Cys Thr Tyr 
            20                  25                  30          


Leu Asp Leu Leu Gly Thr Trp Val Phe Gln Val Gly Ser Ser Gly Ser 
        35                  40                  45              


Gln Arg Asp Val Asn Cys Ser Val Met Gly Pro Gln Glu Lys Lys Val 
    50                  55                  60                  


Val Val Tyr Leu Gln Lys Leu Asp Thr Ala Tyr Asp Asp Leu Gly Asn 
65                  70                  75                  80  


Ser Gly His Phe Thr Ile Ile Tyr Asn Gln Gly Phe Glu Ile Val Leu 
                85                  90                  95      


Asn Asp Tyr Lys Trp Phe Ala Phe Phe Lys Tyr Lys Glu Glu Gly Ser 
            100                 105                 110         


Lys Val Thr Thr Tyr Cys Asn Glu Thr Met Thr Gly Trp Val His Asp 
        115                 120                 125             


Val Leu Gly Arg Asn Trp Ala Cys Phe Thr Gly Lys Lys Val Gly Thr 
    130                 135                 140                 


Ala Ser Glu Asn Val Tyr Val Asn Ile Ala His Leu Lys Asn Ser Gln 
145                 150                 155                 160 


Glu Lys Tyr Ser Asn Arg Leu Tyr Lys Tyr Asp His Asn Phe Val Lys 
                165                 170                 175     


Ala Ile Asn Ala Ile Gln Lys Ser Trp Thr Ala Thr Thr Tyr Met Glu 
            180                 185                 190         


Tyr Glu Thr Leu Thr Leu Gly Asp Met Ile Arg Arg Ser Gly Gly His 
        195                 200                 205             


Ser Arg Lys Ile Pro Arg Pro Lys Pro Ala Pro Leu Thr Ala Glu Ile 
    210                 215                 220                 


Gln Gln Lys Ile Leu His Leu Pro Thr Ser Trp Asp Trp Arg Asn Val 
225                 230                 235                 240 


His Gly Ile Asn Phe Val Ser Pro Val Arg Asn Gln Ala Ser Cys Gly 
                245                 250                 255     


Ser Cys Tyr Ser Phe Ala Ser Met Gly Met Leu Glu Ala Arg Ile Arg 
            260                 265                 270         


Ile Leu Thr Asn Asn Ser Gln Thr Pro Ile Leu Ser Pro Gln Glu Val 
        275                 280                 285             


Val Ser Cys Ser Gln Tyr Ala Gln Gly Cys Glu Gly Gly Phe Pro Tyr 
    290                 295                 300                 


Leu Ile Ala Gly Lys Tyr Ala Gln Asp Phe Gly Leu Val Glu Glu Ala 
305                 310                 315                 320 


Cys Phe Pro Tyr Thr Gly Thr Asp Ser Pro Cys Lys Met Lys Glu Asp 
                325                 330                 335     


Cys Phe Arg Tyr Tyr Ser Ser Glu Tyr His Tyr Val Gly Gly Phe Tyr 
            340                 345                 350         


Gly Gly Cys Asn Glu Ala Leu Met Lys Leu Glu Leu Val His His Gly 
        355                 360                 365             


Pro Met Ala Val Ala Phe Glu Val Tyr Asp Asp Phe Leu His Tyr Lys 
    370                 375                 380                 


Lys Gly Ile Tyr His His Thr Gly Leu Arg Asp Pro Phe Asn Pro Phe 
385                 390                 395                 400 


Glu Leu Thr Asn His Ala Val Leu Leu Val Gly Tyr Gly Thr Asp Ser 
                405                 410                 415     


Ala Ser Gly Met Asp Tyr Trp Ile Val Lys Asn Ser Trp Gly Thr Gly 
            420                 425                 430         


Trp Gly Glu Asn Gly Tyr Phe Arg Ile Arg Arg Gly Thr Asp Glu Cys 
        435                 440                 445             


Ala Ile Glu Ser Ile Ala Val Ala Ala Thr Pro Ile Pro Lys Leu 
    450                 455                 460             


<210>  193
<211>  137
<212>  PRT
<213>  Homo sapiens

<400>  193

Met Gly Ala Gly Pro Ser Leu Leu Leu Ala Ala Leu Leu Leu Leu Leu 
1               5                   10                  15      


Ser Gly Asp Gly Ala Val Arg Cys Asp Thr Pro Ala Asn Cys Thr Tyr 
            20                  25                  30          


Leu Asp Leu Leu Gly Thr Trp Val Phe Gln Val Gly Ser Ser Gly Ser 
        35                  40                  45              


Gln Arg Asp Val Asn Cys Ser Val Met Gly Pro Gln Glu Lys Lys Val 
    50                  55                  60                  


Val Val Tyr Leu Gln Lys Leu Asp Thr Ala Tyr Asp Asp Leu Gly Asn 
65                  70                  75                  80  


Ser Gly His Phe Thr Ile Ile Tyr Asn Gln Gly Phe Glu Ile Val Leu 
                85                  90                  95      


Asn Asp Tyr Lys Trp Phe Ala Phe Phe Lys Asp Val Thr Asp Phe Ile 
            100                 105                 110         


Ser His Leu Phe Met Gln Leu Gly Thr Val Gly Ile Tyr Asp Leu Pro 
        115                 120                 125             


His Leu Arg Asn Lys Leu Val Ile Lys 
    130                 135         


<210>  194
<211>  245
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  194

Xaa Val Val Asp Ser Pro Leu Ala Arg Ser Ala Arg Leu Pro Gly Pro 
1               5                   10                  15      


Gln Glu Lys Lys Val Val Val Tyr Leu Gln Lys Leu Asp Thr Ala Tyr 
            20                  25                  30          


Asp Asp Leu Gly Asn Ser Gly His Phe Thr Ile Ile Tyr Asn Gln Gly 
        35                  40                  45              


Phe Glu Ile Val Leu Asn Asp Tyr Lys Trp Phe Ala Phe Phe Lys Tyr 
    50                  55                  60                  


Lys Glu Glu Gly Ser Lys Val Thr Thr Tyr Cys Asn Glu Thr Met Thr 
65                  70                  75                  80  


Gly Trp Val His Asp Val Leu Gly Arg Asn Trp Ala Cys Phe Thr Gly 
                85                  90                  95      


Lys Lys Val Gly Thr Ala Ser Glu Asn Val Tyr Val Asn Ile Ala His 
            100                 105                 110         


Leu Lys Asn Ser Gln Glu Lys Tyr Ser Asn Arg Leu Tyr Lys Tyr Asp 
        115                 120                 125             


His Asn Phe Val Lys Ala Ile Asn Ala Ile Gln Lys Ser Trp Thr Ala 
    130                 135                 140                 


Thr Thr Tyr Met Glu Tyr Glu Thr Leu Thr Leu Gly Asp Met Ile Arg 
145                 150                 155                 160 


Arg Ser Gly Gly His Ser Arg Lys Ile Pro Arg Pro Lys Pro Ala Pro 
                165                 170                 175     


Leu Thr Ala Glu Ile Gln Gln Lys Ile Leu His Leu Pro Thr Ser Trp 
            180                 185                 190         


Asp Trp Arg Asn Val His Gly Ile Asn Phe Val Ser Pro Val Arg Asn 
        195                 200                 205             


Gln Ala Ser Cys Gly Ser Cys Tyr Ser Phe Ala Ser Met Gly Met Leu 
    210                 215                 220                 


Glu Ala Arg Ile Arg Ile Leu Thr Asn Asn Ser Gln Thr Pro Ile Leu 
225                 230                 235                 240 


Ser Pro Gln Glu Val 
                245 


<210>  195
<211>  36
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  195

Xaa Asp Val Thr Asp Phe Ile Ser His Leu Phe Met Gln Leu Gly Thr 
1               5                   10                  15      


Val Gly Ile Tyr Asp Leu Pro His Leu Arg Asn Lys Leu Ala Met Asn 
            20                  25                  30          


Arg Arg Trp Gly 
        35      


<210>  196
<211>  141
<212>  PRT
<213>  Homo sapiens

<400>  196

Met Gly Ala Gly Pro Ser Leu Leu Leu Ala Ala Leu Leu Leu Leu Leu 
1               5                   10                  15      


Ser Gly Asp Gly Ala Val Arg Cys Asp Thr Pro Ala Asn Cys Thr Tyr 
            20                  25                  30          


Leu Asp Leu Leu Gly Thr Trp Val Phe Gln Val Gly Ser Ser Gly Ser 
        35                  40                  45              


Gln Arg Asp Val Asn Cys Ser Val Met Gly Pro Gln Glu Lys Lys Val 
    50                  55                  60                  


Val Val Tyr Leu Gln Lys Leu Asp Thr Ala Tyr Asp Asp Leu Gly Asn 
65                  70                  75                  80  


Ser Gly His Phe Thr Ile Ile Tyr Asn Gln Gly Phe Glu Ile Val Leu 
                85                  90                  95      


Asn Asp Tyr Lys Trp Phe Ala Phe Phe Lys Asp Val Thr Asp Phe Ile 
            100                 105                 110         


Ser His Leu Phe Met Gln Leu Gly Thr Val Gly Ile Tyr Asp Leu Pro 
        115                 120                 125             


His Leu Arg Asn Lys Leu Ala Met Asn Arg Arg Trp Gly 
    130                 135                 140     


<210>  197
<211>  431
<212>  PRT
<213>  Homo sapiens

<400>  197

Met Ser Ser Val Cys Asp Met Ser Phe Leu Gln Lys Ser Cys Ile Thr 
1               5                   10                  15      


Met Val His Phe Cys Gly Leu Leu Thr Leu His Arg Glu Pro Val Pro 
            20                  25                  30          


Leu Lys Ser Ile Ser Val Ser Val Asn Ile Tyr Glu Phe Val Ala Gly 
        35                  40                  45              


Val Ser Ala Thr Leu Asn Tyr Glu Asn Glu Glu Lys Val Pro Leu Glu 
    50                  55                  60                  


Ala Phe Phe Val Phe Pro Met Asp Glu Asp Ser Ala Val Tyr Ser Phe 
65                  70                  75                  80  


Glu Ala Leu Val Asp Gly Lys Lys Ile Val Ala Glu Leu Gln Asp Lys 
                85                  90                  95      


Met Lys Ala Arg Thr Asn Tyr Glu Lys Ala Ile Ser Gln Gly His Gln 
            100                 105                 110         


Ala Phe Leu Leu Glu Gly Asp Ser Ser Ser Arg Asp Val Phe Ser Cys 
        115                 120                 125             


Asn Val Gly Asn Leu Gln Pro Gly Ser Lys Ala Ala Val Thr Leu Lys 
    130                 135                 140                 


Tyr Val Gln Glu Leu Pro Leu Glu Ala Asp Gly Ala Leu Arg Phe Val 
145                 150                 155                 160 


Leu Pro Ala Val Leu Asn Pro Arg Tyr Gln Phe Ser Gly Ser Ser Lys 
                165                 170                 175     


Asp Ser Cys Leu Asn Val Lys Thr Pro Ile Val Pro Val Glu Asp Leu 
            180                 185                 190         


Pro Tyr Thr Leu Ser Met Val Ala Thr Ile Asp Ser Gln His Gly Ile 
        195                 200                 205             


Glu Lys Val Gln Ser Asn Cys Pro Leu Ser Pro Thr Glu Tyr Leu Gly 
    210                 215                 220                 


Glu Asp Lys Thr Ser Ala Gln Val Ser Leu Ala Ala Gly His Lys Phe 
225                 230                 235                 240 


Asp Arg Asp Val Glu Leu Leu Ile Tyr Tyr Asn Glu Val His Thr Pro 
                245                 250                 255     


Ser Val Val Leu Glu Met Gly Met Pro Asn Met Lys Pro Gly His Leu 
            260                 265                 270         


Met Gly Asp Pro Ser Ala Met Val Ser Phe Tyr Pro Asn Ile Pro Glu 
        275                 280                 285             


Asp Gln Pro Ser Asn Thr Cys Gly Glu Phe Ile Phe Leu Met Asp Arg 
    290                 295                 300                 


Ser Gly Ser Met Gln Ser Pro Met Ser Ser Gln Asp Thr Ser Gln Leu 
305                 310                 315                 320 


Arg Ile Gln Ala Ala Lys Glu Thr Leu Ile Leu Leu Leu Lys Ser Leu 
                325                 330                 335     


Pro Ile Gly Cys Tyr Phe Asn Ile Tyr Gly Phe Gly Ser Ser Tyr Glu 
            340                 345                 350         


Ala Cys Phe Pro Glu Ser Val Lys Tyr Thr Gln Gln Thr Met Glu Glu 
        355                 360                 365             


Ala Leu Gly Arg Val Lys Leu Met Gln Ala Asp Leu Gly Gly Thr Glu 
    370                 375                 380                 


Ile Leu Ala Pro Leu Gln Asn Ile Tyr Arg Gly Pro Ser Ile Pro Gly 
385                 390                 395                 400 


His Pro Leu Gln Leu Phe Val Phe Thr Asp Gly Glu Val Thr Asp Thr 
                405                 410                 415     


Phe Ser Val Ile Lys Glu Val Arg Ile Asn Arg Gln Lys His Arg 
            420                 425                 430     


<210>  198
<211>  786
<212>  PRT
<213>  Homo sapiens

<400>  198

Met Val His Phe Cys Gly Leu Leu Thr Leu His Arg Glu Pro Val Pro 
1               5                   10                  15      


Leu Lys Ser Ile Ser Val Ser Val Asn Ile Tyr Glu Phe Val Ala Gly 
            20                  25                  30          


Val Ser Ala Thr Leu Asn Tyr Glu Asn Glu Glu Lys Val Pro Leu Glu 
        35                  40                  45              


Ala Phe Phe Val Phe Pro Met Asp Glu Asp Ser Ala Val Tyr Ser Phe 
    50                  55                  60                  


Glu Ala Leu Val Asp Gly Lys Lys Ile Val Ala Glu Leu Gln Asp Lys 
65                  70                  75                  80  


Met Lys Ala Arg Thr Asn Tyr Glu Lys Ala Ile Ser Gln Gly His Gln 
                85                  90                  95      


Ala Phe Leu Leu Glu Gly Asp Ser Ser Ser Arg Asp Val Phe Ser Cys 
            100                 105                 110         


Asn Val Gly Asn Leu Gln Pro Gly Ser Lys Ala Ala Val Thr Leu Lys 
        115                 120                 125             


Tyr Val Gln Glu Leu Pro Leu Glu Ala Asp Gly Ala Leu Arg Phe Val 
    130                 135                 140                 


Leu Pro Ala Val Leu Asn Pro Arg Tyr Gln Phe Ser Gly Ser Ser Lys 
145                 150                 155                 160 


Asp Ser Cys Leu Asn Val Lys Thr Pro Ile Val Pro Val Glu Asp Leu 
                165                 170                 175     


Pro Tyr Thr Leu Ser Met Val Ala Thr Ile Asp Ser Gln His Gly Ile 
            180                 185                 190         


Glu Lys Val Gln Ser Asn Cys Pro Leu Ser Pro Thr Glu Tyr Leu Gly 
        195                 200                 205             


Glu Asp Lys Thr Ser Ala Gln Val Ser Leu Ala Ala Gly His Lys Phe 
    210                 215                 220                 


Asp Arg Asp Val Glu Leu Leu Ile Tyr Tyr Asn Glu Val His Thr Pro 
225                 230                 235                 240 


Ser Val Val Leu Glu Met Gly Met Pro Asn Met Lys Pro Gly His Leu 
                245                 250                 255     


Met Gly Asp Pro Ser Ala Met Val Ser Phe Tyr Pro Asn Ile Pro Glu 
            260                 265                 270         


Asp Gln Pro Ser Asn Thr Cys Gly Glu Phe Ile Phe Leu Met Asp Arg 
        275                 280                 285             


Ser Gly Ser Met Gln Ser Pro Met Ser Ser Gln Asp Thr Ser Gln Leu 
    290                 295                 300                 


Arg Ile Gln Ala Ala Lys Glu Thr Leu Ile Leu Leu Leu Lys Ser Leu 
305                 310                 315                 320 


Pro Ile Gly Cys Tyr Phe Asn Ile Tyr Gly Phe Gly Ser Ser Tyr Glu 
                325                 330                 335     


Ala Cys Phe Pro Glu Ser Val Lys Tyr Thr Gln Gln Thr Met Glu Glu 
            340                 345                 350         


Ala Leu Gly Arg Val Lys Leu Met Gln Ala Asp Leu Gly Gly Thr Glu 
        355                 360                 365             


Ile Leu Ala Pro Leu Gln Asn Ile Tyr Arg Gly Pro Ser Ile Pro Gly 
    370                 375                 380                 


His Pro Leu Gln Leu Phe Val Phe Thr Asp Gly Glu Val Thr Asp Thr 
385                 390                 395                 400 


Phe Ser Val Ile Lys Glu Val Arg Ile Asn Arg Gln Lys His Arg Cys 
                405                 410                 415     


Phe Ser Phe Gly Ile Gly Glu Gly Thr Ser Thr Ser Leu Ile Lys Gly 
            420                 425                 430         


Ile Ala Arg Ala Ser Gly Gly Thr Ser Glu Phe Ile Thr Gly Lys Asp 
        435                 440                 445             


Arg Met Gln Ser Lys Ala Leu Arg Thr Leu Lys Arg Ser Leu Gln Pro 
    450                 455                 460                 


Val Val Glu Asp Val Ser Leu Ser Trp His Leu Pro Pro Gly Leu Ser 
465                 470                 475                 480 


Ala Lys Met Leu Ser Pro Glu Gln Thr Val Ile Phe Arg Gly Gln Arg 
                485                 490                 495     


Leu Ile Ser Tyr Ala Gln Leu Thr Gly Arg Met Pro Ala Ala Glu Thr 
            500                 505                 510         


Thr Gly Glu Val Cys Leu Lys Tyr Thr Leu Gln Gly Lys Thr Phe Glu 
        515                 520                 525             


Asp Lys Val Thr Phe Pro Leu Gln Pro Lys Pro Asp Val Asn Leu Thr 
    530                 535                 540                 


Ile His Arg Leu Ala Ala Lys Ser Leu Leu Gln Thr Lys Asp Met Gly 
545                 550                 555                 560 


Leu Arg Glu Thr Pro Ala Ser Asp Lys Lys Asp Ala Leu Asn Leu Ser 
                565                 570                 575     


Leu Glu Ser Gly Val Ile Ser Ser Phe Thr Ala Phe Ile Ala Ile Asn 
            580                 585                 590         


Lys Glu Leu Asn Lys Pro Val Gln Gly Pro Leu Ala His Arg Asp Val 
        595                 600                 605             


Pro Arg Pro Ile Leu Leu Gly Ala Ser Ala Pro Leu Lys Ile Lys Cys 
    610                 615                 620                 


Gln Ser Gly Phe Arg Lys Ala Leu His Ser Asp Arg Pro Pro Ser Ala 
625                 630                 635                 640 


Ser Gln Pro Arg Gly Glu Leu Met Cys Tyr Lys Ala Lys Thr Phe Gln 
                645                 650                 655     


Met Asp Asp Tyr Ser Leu Cys Gly Leu Ile Ser His Lys Asp Gln His 
            660                 665                 670         


Ser Pro Gly Phe Gly Glu Asn His Leu Val Gln Leu Ile Tyr His Gln 
        675                 680                 685             


Asn Ala Asn Gly Ser Trp Asp Leu Asn Glu Asp Leu Ala Lys Ile Leu 
    690                 695                 700                 


Gly Met Ser Leu Glu Glu Ile Met Ala Ala Gln Pro Ala Glu Leu Val 
705                 710                 715                 720 


Asp Ser Ser Gly Trp Ala Thr Ile Leu Ala Val Ile Trp Leu His Ser 
                725                 730                 735     


Asn Gly Lys Asp Leu Lys Cys Glu Trp Glu Leu Leu Glu Arg Lys Ala 
            740                 745                 750         


Val Ala Trp Met Arg Ala His Ala Gly Ser Thr Met Pro Ser Val Val 
        755                 760                 765             


Lys Ala Ala Ile Thr Phe Leu Lys Ser Ser Val Asp Pro Ala Ile Phe 
    770                 775                 780                 


Ala Phe 
785     


<210>  199
<211>  786
<212>  PRT
<213>  Homo sapiens

<400>  199

Met Val His Phe Cys Gly Leu Leu Thr Leu His Arg Glu Pro Val Pro 
1               5                   10                  15      


Leu Lys Ser Ile Ser Val Ser Val Asn Ile Tyr Glu Phe Val Ala Gly 
            20                  25                  30          


Val Ser Ala Thr Leu Asn Tyr Glu Asn Glu Glu Lys Val Pro Leu Glu 
        35                  40                  45              


Ala Phe Phe Val Phe Pro Met Asp Glu Asp Ser Ala Val Tyr Ser Phe 
    50                  55                  60                  


Glu Ala Leu Val Asp Gly Lys Lys Ile Val Ala Glu Leu Gln Asp Lys 
65                  70                  75                  80  


Met Lys Ala Arg Thr Asn Tyr Glu Lys Ala Ile Ser Gln Gly His Gln 
                85                  90                  95      


Ala Phe Leu Leu Glu Gly Asp Ser Ser Ser Arg Asp Val Phe Ser Cys 
            100                 105                 110         


Asn Val Gly Asn Leu Gln Pro Gly Ser Lys Ala Ala Val Thr Leu Lys 
        115                 120                 125             


Tyr Val Gln Glu Leu Pro Leu Glu Ala Asp Gly Ala Leu Arg Phe Val 
    130                 135                 140                 


Leu Pro Ala Val Leu Asn Pro Arg Tyr Gln Phe Ser Gly Ser Ser Lys 
145                 150                 155                 160 


Asp Ser Cys Leu Asn Val Lys Thr Pro Ile Val Pro Val Glu Asp Leu 
                165                 170                 175     


Pro Tyr Thr Leu Ser Met Val Ala Thr Ile Asp Ser Gln His Gly Ile 
            180                 185                 190         


Glu Lys Val Gln Ser Asn Cys Pro Leu Ser Pro Thr Glu Tyr Leu Gly 
        195                 200                 205             


Glu Asp Lys Thr Ser Ala Gln Val Ser Leu Ala Ala Gly His Lys Phe 
    210                 215                 220                 


Asp Arg Asp Val Glu Leu Leu Ile Tyr Tyr Asn Glu Val His Thr Pro 
225                 230                 235                 240 


Ser Val Val Leu Glu Met Gly Met Pro Asn Met Lys Pro Gly His Leu 
                245                 250                 255     


Met Gly Asp Pro Ser Ala Met Val Ser Phe Tyr Pro Asn Ile Pro Glu 
            260                 265                 270         


Asp Gln Pro Ser Asn Thr Cys Gly Glu Phe Ile Phe Leu Met Asp Arg 
        275                 280                 285             


Ser Gly Ser Met Gln Ser Pro Met Ser Ser Gln Asp Thr Ser Gln Leu 
    290                 295                 300                 


Arg Ile Gln Ala Ala Lys Glu Thr Leu Ile Leu Leu Leu Lys Ser Leu 
305                 310                 315                 320 


Pro Ile Gly Cys Tyr Phe Asn Ile Tyr Gly Phe Gly Ser Ser Tyr Glu 
                325                 330                 335     


Ala Cys Phe Pro Glu Ser Val Lys Tyr Thr Gln Gln Thr Met Glu Glu 
            340                 345                 350         


Ala Leu Gly Arg Val Lys Leu Met Gln Ala Asp Leu Gly Gly Thr Glu 
        355                 360                 365             


Ile Leu Ala Pro Leu Gln Asn Ile Tyr Arg Gly Pro Ser Ile Pro Gly 
    370                 375                 380                 


His Pro Leu Gln Leu Phe Val Phe Thr Asp Gly Glu Val Thr Asp Thr 
385                 390                 395                 400 


Phe Ser Val Ile Lys Glu Val Arg Ile Asn Arg Gln Lys His Arg Cys 
                405                 410                 415     


Phe Ser Phe Gly Ile Gly Glu Gly Thr Ser Thr Ser Leu Ile Lys Gly 
            420                 425                 430         


Ile Ala Arg Ala Ser Gly Gly Thr Ser Glu Phe Ile Thr Gly Lys Asp 
        435                 440                 445             


Arg Met Gln Ser Lys Ala Leu Arg Thr Leu Lys Arg Ser Leu Gln Pro 
    450                 455                 460                 


Val Val Glu Asp Val Ser Leu Ser Trp His Leu Pro Pro Gly Leu Ser 
465                 470                 475                 480 


Ala Lys Met Leu Ser Pro Glu Gln Thr Val Ile Phe Arg Gly Gln Arg 
                485                 490                 495     


Leu Ile Ser Tyr Ala Gln Leu Thr Gly Arg Met Pro Ala Ala Glu Thr 
            500                 505                 510         


Thr Gly Glu Val Cys Leu Lys Tyr Thr Leu Gln Gly Lys Thr Phe Glu 
        515                 520                 525             


Asp Lys Val Thr Phe Pro Leu Gln Pro Lys Pro Asp Val Asn Leu Thr 
    530                 535                 540                 


Ile His Arg Leu Ala Ala Lys Ser Leu Leu Gln Thr Lys Asp Met Gly 
545                 550                 555                 560 


Leu Arg Glu Thr Pro Ala Ser Asp Lys Lys Asp Ala Leu Asn Leu Ser 
                565                 570                 575     


Leu Glu Ser Gly Val Ile Ser Ser Phe Thr Ala Phe Ile Ala Ile Asn 
            580                 585                 590         


Lys Glu Leu Asn Lys Pro Val Gln Gly Pro Leu Ala His Arg Asp Val 
        595                 600                 605             


Pro Arg Pro Ile Leu Leu Gly Ala Ser Ala Pro Leu Lys Ile Lys Cys 
    610                 615                 620                 


Gln Ser Gly Phe Arg Lys Ala Leu His Ser Asp Arg Pro Pro Ser Ala 
625                 630                 635                 640 


Ser Gln Pro Arg Gly Glu Leu Met Cys Tyr Lys Ala Lys Thr Phe Gln 
                645                 650                 655     


Met Asp Asp Tyr Ser Leu Cys Gly Leu Ile Ser His Lys Asp Gln His 
            660                 665                 670         


Ser Pro Gly Phe Gly Glu Asn His Leu Val Gln Leu Ile Tyr His Gln 
        675                 680                 685             


Asn Ala Asn Gly Ser Trp Asp Leu Asn Glu Asp Leu Ala Lys Ile Leu 
    690                 695                 700                 


Gly Met Ser Leu Glu Glu Ile Met Ala Ala Gln Pro Ala Glu Leu Val 
705                 710                 715                 720 


Asp Ser Ser Gly Trp Ala Thr Ile Leu Ala Val Ile Trp Leu His Ser 
                725                 730                 735     


Asn Gly Lys Asp Leu Lys Cys Glu Trp Glu Leu Leu Glu Arg Lys Ala 
            740                 745                 750         


Val Ala Trp Met Arg Ala His Ala Gly Ser Thr Met Pro Ser Val Val 
        755                 760                 765             


Lys Ala Ala Ile Thr Phe Leu Lys Ser Ser Val Asp Pro Ala Ile Phe 
    770                 775                 780                 


Ala Phe 
785     


<210>  200
<211>  327
<212>  PRT
<213>  Homo sapiens

<400>  200

Met Leu Ser Leu Cys Ile Cys Gly Thr Ala Ile Thr Ser Gln Tyr Leu 
1               5                   10                  15      


Ala Glu Arg Tyr Lys Val Asn Thr Pro Met Leu Gln Ser Phe Ile Asn 
            20                  25                  30          


Tyr Cys Leu Leu Phe Leu Ile Tyr Thr Val Met Leu Ala Phe Arg Ser 
        35                  40                  45              


Gly Ser Asp Asn Leu Leu Val Ile Leu Lys Arg Lys Trp Trp Lys Tyr 
    50                  55                  60                  


Ile Leu Leu Gly Leu Ala Asp Val Glu Ala Asn Tyr Val Ile Val Arg 
65                  70                  75                  80  


Ala Tyr Gln Tyr Thr Thr Leu Thr Ser Val Gln Leu Leu Asp Cys Phe 
                85                  90                  95      


Gly Ile Pro Val Leu Met Ala Leu Ser Trp Phe Ile Leu His Ala Arg 
            100                 105                 110         


Tyr Arg Val Ile His Phe Ile Ala Val Ala Val Cys Leu Leu Gly Val 
        115                 120                 125             


Gly Thr Met Val Gly Ala Asp Ile Leu Ala Gly Arg Glu Asp Asn Ser 
    130                 135                 140                 


Gly Ser Asp Val Leu Ile Gly Asp Ile Leu Val Leu Leu Gly Ala Ser 
145                 150                 155                 160 


Leu Tyr Ala Ile Ser Asn Val Cys Glu Glu Tyr Ile Val Lys Lys Leu 
                165                 170                 175     


Ser Arg Gln Glu Phe Leu Gly Met Val Gly Leu Phe Gly Thr Ile Ile 
            180                 185                 190         


Ser Gly Ile Gln Leu Leu Ile Val Glu Tyr Lys Asp Ile Ala Ser Ile 
        195                 200                 205             


His Trp Asp Trp Lys Ile Ala Leu Leu Phe Val Ala Phe Ala Leu Cys 
    210                 215                 220                 


Met Phe Cys Leu Tyr Ser Phe Met Pro Leu Val Ile Lys Val Thr Ser 
225                 230                 235                 240 


Ala Thr Ser Val Asn Leu Gly Ile Leu Thr Ala Asp Leu Tyr Ser Leu 
                245                 250                 255     


Phe Val Gly Leu Phe Leu Phe Gly Tyr Lys Phe Ser Gly Leu Tyr Ile 
            260                 265                 270         


Leu Ser Phe Thr Val Ile Met Val Gly Phe Ile Leu Tyr Cys Ser Thr 
        275                 280                 285             


Pro Thr Arg Thr Ala Glu Pro Ala Glu Ser Ser Val Pro Pro Val Thr 
    290                 295                 300                 


Ser Ile Gly Ile Asp Asn Leu Gly Leu Lys Leu Glu Glu Asn Leu Gln 
305                 310                 315                 320 


Glu Thr His Ser Ala Val Leu 
                325         


<210>  201
<211>  357
<212>  PRT
<213>  Homo sapiens

<400>  201

Met Glu Ala Asp Ser Pro Ala Gly Pro Gly Ala Pro Glu Pro Leu Ala 
1               5                   10                  15      


Glu Gly Ala Ala Ala Glu Phe Ser Ser Leu Leu Arg Arg Ile Lys Gly 
            20                  25                  30          


Lys Leu Phe Thr Trp Asn Ile Leu Lys Thr Ile Ala Leu Gly Gln Met 
        35                  40                  45              


Leu Ser Leu Cys Ile Cys Gly Thr Ala Ile Thr Ser Gln Tyr Leu Ala 
    50                  55                  60                  


Glu Arg Tyr Lys Val Asn Thr Pro Met Leu Gln Ser Phe Ile Asn Tyr 
65                  70                  75                  80  


Cys Leu Leu Phe Leu Ile Tyr Thr Val Met Leu Ala Phe Arg Ser Gly 
                85                  90                  95      


Ser Asp Asn Leu Leu Val Ile Leu Lys Arg Lys Trp Trp Lys Tyr Ile 
            100                 105                 110         


Leu Leu Gly Leu Ala Asp Val Glu Ala Asn Tyr Val Ile Val Arg Ala 
        115                 120                 125             


Tyr Gln Tyr Thr Thr Leu Thr Ser Val Gln Leu Leu Asp Cys Phe Gly 
    130                 135                 140                 


Ile Pro Val Leu Met Ala Leu Ser Trp Phe Ile Leu His Ala Arg Tyr 
145                 150                 155                 160 


Arg Val Ile His Phe Ile Ala Val Ala Val Cys Leu Leu Gly Val Gly 
                165                 170                 175     


Thr Met Val Gly Ala Asp Ile Leu Ala Gly Arg Glu Asp Asn Ser Gly 
            180                 185                 190         


Ser Asp Val Leu Ile Gly Asp Ile Leu Val Leu Leu Gly Ala Ser Leu 
        195                 200                 205             


Tyr Ala Ile Ser Asn Val Cys Glu Glu Tyr Ile Val Lys Lys Leu Ser 
    210                 215                 220                 


Arg Gln Glu Phe Leu Gly Met Val Gly Leu Phe Gly Thr Ile Ile Ser 
225                 230                 235                 240 


Gly Ile Gln Leu Leu Ile Val Glu Tyr Lys Asp Ile Ala Ser Ile His 
                245                 250                 255     


Trp Asp Trp Lys Ile Ala Leu Leu Phe Val Ala Phe Ala Leu Cys Met 
            260                 265                 270         


Phe Cys Leu Tyr Ser Phe Met Pro Leu Val Ile Lys Val Thr Ser Ala 
        275                 280                 285             


Thr Ser Val Asn Leu Gly Ile Leu Thr Ala Asp Leu Tyr Ser Leu Phe 
    290                 295                 300                 


Val Gly Leu Phe Leu Phe Gly Tyr Lys Asp Ser Thr Ser Cys Pro Ser 
305                 310                 315                 320 


Leu Ser Ser Trp Trp Gly Leu Ser Cys Thr Ala Pro Pro Leu Leu Ala 
                325                 330                 335     


Arg Pro Ser Arg Leu Lys Ala Ala Cys Leu Gln Ser Pro Ala Leu Gly 
            340                 345                 350         


Leu Thr Thr Trp Gly 
        355         


<210>  202
<211>  374
<212>  PRT
<213>  Homo sapiens

<400>  202

Met Glu Ala Asp Ser Pro Ala Gly Pro Gly Ala Pro Glu Pro Leu Ala 
1               5                   10                  15      


Glu Gly Ala Ala Ala Glu Phe Ser Ser Leu Leu Arg Arg Ile Lys Gly 
            20                  25                  30          


Lys Leu Phe Thr Trp Asn Ile Leu Lys Thr Ile Ala Leu Gly Gln Met 
        35                  40                  45              


Leu Ser Leu Cys Ile Cys Gly Thr Ala Ile Thr Ser Gln Tyr Leu Ala 
    50                  55                  60                  


Glu Arg Tyr Lys Val Asn Thr Pro Met Leu Gln Ser Phe Ile Asn Tyr 
65                  70                  75                  80  


Cys Leu Leu Phe Leu Ile Tyr Thr Val Met Leu Ala Phe Arg Ser Gly 
                85                  90                  95      


Ser Asp Asn Leu Leu Val Ile Leu Lys Arg Lys Trp Trp Lys Tyr Ile 
            100                 105                 110         


Leu Leu Gly Leu Ala Asp Val Glu Ala Asn Tyr Val Ile Val Arg Ala 
        115                 120                 125             


Tyr Gln Tyr Thr Thr Leu Thr Ser Val Gln Leu Leu Asp Cys Phe Gly 
    130                 135                 140                 


Ile Pro Val Leu Met Ala Leu Ser Trp Phe Ile Leu His Ala Arg Tyr 
145                 150                 155                 160 


Arg Val Ile His Phe Ile Ala Val Ala Val Cys Leu Leu Gly Val Gly 
                165                 170                 175     


Thr Met Val Gly Ala Asp Ile Leu Ala Gly Arg Glu Asp Asn Ser Gly 
            180                 185                 190         


Ser Asp Val Leu Ile Gly Asp Ile Leu Val Leu Leu Gly Ala Ser Leu 
        195                 200                 205             


Tyr Ala Ile Ser Asn Val Cys Glu Glu Tyr Ile Val Lys Lys Leu Ser 
    210                 215                 220                 


Arg Gln Glu Phe Leu Gly Met Val Gly Leu Phe Gly Thr Ile Ile Ser 
225                 230                 235                 240 


Gly Ile Gln Leu Leu Ile Val Glu Tyr Lys Asp Ile Ala Ser Ile His 
                245                 250                 255     


Trp Asp Trp Lys Ile Ala Leu Leu Phe Val Ala Phe Ala Leu Cys Met 
            260                 265                 270         


Phe Cys Leu Tyr Ser Phe Met Pro Leu Val Ile Lys Val Thr Ser Ala 
        275                 280                 285             


Thr Ser Val Asn Leu Gly Ile Leu Thr Ala Asp Leu Tyr Ser Leu Phe 
    290                 295                 300                 


Val Gly Leu Phe Leu Phe Gly Tyr Lys Phe Ser Gly Leu Tyr Ile Leu 
305                 310                 315                 320 


Ser Phe Thr Val Ile Met Val Gly Phe Ile Leu Tyr Cys Ser Thr Pro 
                325                 330                 335     


Thr Arg Thr Ala Glu Pro Ala Glu Ser Ser Val Pro Pro Val Thr Ser 
            340                 345                 350         


Ile Gly Ile Asp Asn Leu Gly Leu Lys Leu Glu Glu Asn Leu Gln Glu 
        355                 360                 365             


Thr His Ser Ala Val Leu 
    370                 


<210>  203
<211>  265
<212>  PRT
<213>  Homo sapiens

<400>  203

Met Glu Ala Asp Ser Pro Ala Gly Pro Gly Ala Pro Glu Pro Leu Ala 
1               5                   10                  15      


Glu Gly Ala Ala Ala Glu Phe Ser Ser Leu Leu Arg Arg Ile Lys Gly 
            20                  25                  30          


Lys Leu Phe Thr Trp Asn Ile Leu Lys Thr Ile Ala Leu Gly Gln Met 
        35                  40                  45              


Leu Ser Leu Cys Ile Cys Gly Thr Ala Ile Thr Ser Gln Tyr Leu Ala 
    50                  55                  60                  


Glu Arg Tyr Lys Val Asn Thr Pro Met Leu Gln Ser Phe Ile Asn Tyr 
65                  70                  75                  80  


Cys Leu Leu Phe Leu Ile Tyr Thr Val Met Leu Ala Phe Arg Ser Gly 
                85                  90                  95      


Ser Asp Asn Leu Leu Val Ile Leu Lys Arg Lys Trp Trp Lys Tyr Ile 
            100                 105                 110         


Leu Leu Gly Leu Ala Asp Val Glu Ala Asn Tyr Val Ile Val Arg Ala 
        115                 120                 125             


Tyr Gln Tyr Thr Thr Leu Thr Ser Val Gln Leu Leu Asp Cys Phe Gly 
    130                 135                 140                 


Ile Pro Val Leu Met Ala Leu Ser Trp Phe Ile Leu His Ala Arg Tyr 
145                 150                 155                 160 


Arg Val Ile His Phe Ile Ala Val Ala Val Cys Leu Leu Gly Val Gly 
                165                 170                 175     


Thr Met Val Gly Ala Asp Ile Leu Ala Gly Arg Glu Asp Asn Ser Gly 
            180                 185                 190         


Ser Asp Val Leu Ile Gly Asp Ile Leu Val Leu Leu Gly Ala Ser Leu 
        195                 200                 205             


Tyr Ala Ile Ser Asn Val Cys Glu Glu Tyr Ile Val Lys Lys Leu Ser 
    210                 215                 220                 


Arg Gln Glu Phe Leu Gly Met Val Gly Leu Phe Gly Thr Ile Ile Ser 
225                 230                 235                 240 


Gly Ile Gln Leu Pro Ala Val Arg Gly Ile Cys Pro Val Tyr Val Leu 
                245                 250                 255     


Pro Val Gln Leu His Ala Ile Gly Asp 
            260                 265 


<210>  204
<211>  49
<212>  PRT
<213>  Homo sapiens

<400>  204

Met Glu Ala Met Ala Ala Ser Thr Ser Leu Pro Asp Pro Gly Asp Phe 
1               5                   10                  15      


Asp Arg Asn Val Pro Arg Ile Cys Gly Val Cys Gly Asp Arg Ala Thr 
            20                  25                  30          


Gly Phe His Phe Asn Ala Met Thr Cys Glu Gly Cys Lys Gly Phe Phe 
        35                  40                  45              


Arg 
    


<210>  205
<211>  1093
<212>  PRT
<213>  Homo sapiens

<400>  205

Met Ser Gln Pro Gly Ile Pro Ala Ser Gly Gly Ala Pro Ala Ser Leu 
1               5                   10                  15      


Gln Ala Gln Asn Gly Ala Ala Leu Ala Ser Gly Ser Pro Tyr Thr Asn 
            20                  25                  30          


Gly Pro Val Gln Asn Ala Leu Leu Ser Ser Gln Glu Ser Val Ser Gln 
        35                  40                  45              


Gly Tyr Asn Phe Gln Leu Pro Gly Ser Tyr Pro His Pro Ile Pro Ala 
    50                  55                  60                  


Lys Thr Leu Asn Pro Val Ser Gly Gln Ser Asn Tyr Gly Gly Ser Gln 
65                  70                  75                  80  


Gly Ser Gly Gln Thr Leu Asn Arg Pro Pro Val Ala Ser Asn Pro Val 
                85                  90                  95      


Thr Pro Ser Leu His Ser Gly Pro Ala Pro Arg Met Pro Leu Pro Ala 
            100                 105                 110         


Ser Gln Asn Pro Ala Thr Thr Pro Met Pro Ser Ser Ser Phe Leu Pro 
        115                 120                 125             


Glu Ala Asn Leu Pro Pro Pro Leu Asn Trp Gln Tyr Asn Tyr Pro Ser 
    130                 135                 140                 


Thr Ala Ser Gln Thr Asn His Cys Pro Arg Ala Ser Ser Gln Pro Thr 
145                 150                 155                 160 


Val Ser Gly Asn Thr Ser Leu Thr Thr Asn His Gln Tyr Val Ser Ser 
                165                 170                 175     


Gly Tyr Pro Ser Leu Gln Asn Ser Phe Ile Lys Ser Gly Pro Ser Val 
            180                 185                 190         


Pro Pro Leu Val Asn Pro Pro Leu Pro Thr Thr Phe Gln Pro Gly Ala 
        195                 200                 205             


Pro His Gly Pro Pro Pro Ala Gly Gly Pro Pro Pro Val Arg Ala Leu 
    210                 215                 220                 


Thr Pro Leu Thr Ser Ser Tyr Arg Asp Val Pro Gln Pro Leu Phe Asn 
225                 230                 235                 240 


Ser Ala Val Asn Gln Glu Gly Ile Thr Ser Asn Thr Asn Asn Gly Ser 
                245                 250                 255     


Met Val Val His Ser Ser Tyr Asp Glu Ile Glu Gly Gly Gly Leu Leu 
            260                 265                 270         


Ala Thr Pro Gln Leu Thr Asn Lys Asn Pro Lys Met Ser Arg Ser Val 
        275                 280                 285             


Gly Tyr Ser Tyr Pro Ser Leu Pro Pro Gly Tyr Gln Asn Thr Thr Pro 
    290                 295                 300                 


Pro Gly Ala Thr Gly Val Pro Pro Ser Ser Leu Asn Tyr Pro Ser Gly 
305                 310                 315                 320 


Pro Gln Ala Phe Thr Gln Thr Pro Leu Gly Ala Asn His Leu Thr Thr 
                325                 330                 335     


Ser Met Ser Gly Leu Ser Leu Gln Pro Glu Gly Leu Arg Val Val Asn 
            340                 345                 350         


Leu Leu Gln Glu Arg Asn Met Leu Pro Ser Thr Pro Leu Lys Pro Pro 
        355                 360                 365             


Val Pro Asn Leu His Glu Asp Ile Gln Lys Leu Asn Cys Asn Pro Glu 
    370                 375                 380                 


Leu Phe Arg Cys Thr Leu Thr Ser Ile Pro Gln Thr Gln Ala Leu Leu 
385                 390                 395                 400 


Asn Lys Ala Lys Leu Pro Leu Gly Leu Leu Leu His Pro Phe Lys Asp 
                405                 410                 415     


Leu Val Gln Leu Pro Val Val Thr Ser Ser Thr Ile Val Arg Cys Arg 
            420                 425                 430         


Ser Cys Arg Thr Tyr Ile Asn Pro Phe Val Ser Phe Leu Asp Gln Arg 
        435                 440                 445             


Arg Trp Lys Cys Asn Leu Cys Tyr Arg Val Asn Asp Val Pro Glu Glu 
    450                 455                 460                 


Phe Leu Tyr Asn Pro Leu Thr Arg Val Tyr Gly Glu Pro His Arg Arg 
465                 470                 475                 480 


Pro Glu Val Gln Asn Ala Thr Ile Glu Phe Met Ala Pro Ser Glu Tyr 
                485                 490                 495     


Met Leu Arg Pro Pro Gln Pro Pro Val Tyr Leu Phe Val Phe Asp Val 
            500                 505                 510         


Ser His Asn Ala Val Glu Thr Gly Tyr Leu Asn Ser Val Cys Gln Ser 
        515                 520                 525             


Leu Leu Asp Asn Leu Asp Leu Leu Pro Gly Asn Thr Arg Thr Lys Ile 
    530                 535                 540                 


Gly Phe Ile Thr Phe Asp Ser Thr Ile His Phe Tyr Gly Leu Gln Glu 
545                 550                 555                 560 


Ser Leu Ser Gln Pro Gln Met Leu Ile Val Ser Asp Ile Glu Asp Val 
                565                 570                 575     


Phe Ile Pro Met Pro Glu Asn Leu Leu Val Asn Leu Asn Glu Ser Lys 
            580                 585                 590         


Glu Leu Val Gln Asp Leu Leu Lys Thr Leu Pro Gln Met Phe Thr Lys 
        595                 600                 605             


Thr Leu Glu Thr Gln Ser Ala Leu Gly Pro Ala Leu Gln Ala Ala Phe 
    610                 615                 620                 


Lys Leu Met Ser Pro Thr Gly Gly Arg Met Ser Val Phe Gln Thr Gln 
625                 630                 635                 640 


Leu Pro Thr Leu Gly Val Gly Ala Leu Lys Pro Arg Glu Glu Pro Asn 
                645                 650                 655     


His Arg Ser Ser Ala Lys Asp Ile His Met Thr Pro Ser Thr Asp Phe 
            660                 665                 670         


Tyr Lys Lys Leu Ala Leu Asp Cys Ser Gly Gln Gln Val Ala Val Asp 
        675                 680                 685             


Leu Phe Leu Leu Ser Gly Gln Tyr Ser Asp Leu Ala Ser Leu Gly Cys 
    690                 695                 700                 


Ile Ser Arg Tyr Ser Ala Gly Ser Val Tyr Tyr Tyr Pro Ser Tyr His 
705                 710                 715                 720 


His Gln His Asn Pro Val Gln Val Gln Lys Leu Gln Lys Glu Leu Gln 
                725                 730                 735     


Arg Tyr Leu Thr Arg Lys Ile Gly Phe Glu Ala Val Met Arg Ile Arg 
            740                 745                 750         


Cys Thr Lys Gly Leu Ser Ile His Thr Phe His Gly Asn Phe Phe Val 
        755                 760                 765             


Arg Ser Thr Asp Leu Leu Ser Leu Pro Asn Val Asn Pro Asp Ala Gly 
    770                 775                 780                 


Tyr Ala Val Gln Met Ser Val Glu Glu Ser Leu Thr Asp Thr Gln Leu 
785                 790                 795                 800 


Val Ser Phe Gln Ser Ala Leu Leu Tyr Thr Ser Ser Lys Gly Glu Arg 
                805                 810                 815     


Arg Ile Arg Val His Thr Leu Cys Leu Pro Val Val Ser Thr Leu Asn 
            820                 825                 830         


Asp Val Phe Leu Gly Ala Asp Val Gln Ala Ile Ser Gly Leu Leu Ala 
        835                 840                 845             


Asn Met Ala Val Asp Arg Ser Met Thr Ala Ser Leu Ser Asp Ala Arg 
    850                 855                 860                 


Asp Ala Leu Val Asn Ala Val Ile Asp Ser Leu Ser Ala Tyr Arg Ser 
865                 870                 875                 880 


Ser Val Leu Ser Asn Gln Gln Pro Gly Leu Met Val Pro Phe Ser Leu 
                885                 890                 895     


Arg Leu Phe Pro Leu Phe Val Leu Ala Leu Leu Lys Gln Lys Ser Phe 
            900                 905                 910         


Gln Thr Gly Thr Asn Ala Arg Leu Asp Glu Arg Ile Phe Ala Met Cys 
        915                 920                 925             


Gln Val Lys Asn Gln Pro Leu Val Tyr Leu Met Leu Thr Thr His Pro 
    930                 935                 940                 


Ser Leu Tyr Arg Val Asp Asn Leu Ser Asp Glu Gly Ala Leu Asn Ile 
945                 950                 955                 960 


Ser Asp Arg Thr Ile Pro Gln Pro Pro Ile Leu Gln Leu Ser Val Glu 
                965                 970                 975     


Lys Leu Ser Arg Asp Gly Ala Phe Leu Met Asp Ala Gly Ser Val Leu 
            980                 985                 990         


Met Leu Trp Val Gly Lys Asn Cys  Thr Gln Asn Phe Leu  Ser Gln Val 
        995                 1000                 1005             


Leu Gly  Val Gln Asn Tyr Ala  Ser Ile Pro Gln Pro  Met Thr Asp 
    1010                 1015                 1020             


Leu Pro  Glu Leu Asp Thr Pro  Glu Ser Ala Arg Ile  Ile Ala Phe 
    1025                 1030                 1035             


Ile Ser  Trp Leu Arg Glu Gln  Arg Pro Phe Phe Pro  Ile Leu Tyr 
    1040                 1045                 1050             


Val Ile  Arg Asp Glu Ser Pro  Met Lys Ala Asn Phe  Leu Gln Asn 
    1055                 1060                 1065             


Met Ile  Glu Asp Arg Thr Glu  Ser Ala Leu Ser Tyr  Tyr Glu Phe 
    1070                 1075                 1080             


Leu Leu  His Ile Gln Gln Gln  Val Asn Lys 
    1085                 1090             


<210>  206
<211>  398
<212>  PRT
<213>  Homo sapiens

<400>  206

Met Leu Arg Leu Tyr Val Leu Val Met Gly Val Ser Ala Phe Thr Leu 
1               5                   10                  15      


Gln Pro Ala Ala His Thr Gly Ala Ala Arg Ser Cys Arg Phe Arg Gly 
            20                  25                  30          


Arg His Tyr Lys Arg Glu Phe Arg Leu Glu Gly Glu Pro Val Ala Leu 
        35                  40                  45              


Arg Cys Pro Gln Val Pro Tyr Trp Leu Trp Ala Ser Val Ser Pro Arg 
    50                  55                  60                  


Ile Asn Leu Thr Trp His Lys Asn Asp Ser Ala Arg Thr Val Pro Gly 
65                  70                  75                  80  


Glu Glu Glu Thr Arg Met Trp Ala Gln Asp Gly Ala Leu Trp Leu Leu 
                85                  90                  95      


Pro Ala Leu Gln Glu Asp Ser Gly Thr Tyr Val Cys Thr Thr Arg Asn 
            100                 105                 110         


Ala Ser Tyr Cys Asp Lys Met Ser Ile Glu Leu Arg Val Phe Glu Asn 
        115                 120                 125             


Thr Asp Ala Phe Leu Pro Phe Ile Ser Tyr Pro Gln Ile Leu Thr Leu 
    130                 135                 140                 


Ser Thr Ser Gly Val Leu Val Cys Pro Asp Leu Ser Glu Phe Thr Arg 
145                 150                 155                 160 


Asp Lys Thr Asp Val Lys Ile Gln Trp Tyr Lys Asp Ser Leu Leu Leu 
                165                 170                 175     


Asp Lys Asp Asn Glu Lys Phe Leu Ser Val Arg Gly Thr Thr His Leu 
            180                 185                 190         


Leu Val His Asp Val Ala Leu Glu Asp Ala Gly Tyr Tyr Arg Cys Val 
        195                 200                 205             


Leu Thr Phe Ala His Glu Gly Gln Gln Tyr Asn Ile Thr Arg Ser Ile 
    210                 215                 220                 


Glu Leu Arg Ile Lys Lys Lys Lys Glu Glu Thr Ile Pro Val Ile Ile 
225                 230                 235                 240 


Ser Pro Leu Lys Thr Ile Ser Ala Ser Leu Gly Ser Arg Leu Thr Ile 
                245                 250                 255     


Pro Cys Lys Val Phe Leu Gly Thr Gly Thr Pro Leu Thr Thr Met Leu 
            260                 265                 270         


Trp Trp Thr Ala Asn Asp Thr His Ile Glu Ser Ala Tyr Pro Gly Gly 
        275                 280                 285             


Arg Val Thr Glu Gly Pro Arg Gln Glu Tyr Ser Glu Asn Asn Glu Asn 
    290                 295                 300                 


Tyr Ile Glu Val Pro Leu Ile Phe Asp Pro Val Thr Arg Glu Asp Leu 
305                 310                 315                 320 


His Met Asp Phe Lys Cys Val Val His Asn Thr Leu Ser Phe Gln Thr 
                325                 330                 335     


Leu Arg Thr Thr Val Lys Glu Ala Ser Ser Thr Phe Ser Trp Gly Ile 
            340                 345                 350         


Val Leu Ala Pro Leu Ser Leu Ala Phe Leu Val Leu Gly Gly Ile Trp 
        355                 360                 365             


Met His Arg Arg Cys Lys His Arg Thr Gly Lys Ala Asp Gly Leu Thr 
    370                 375                 380                 


Val Leu Trp Pro His His Gln Asp Phe Gln Ser Tyr Pro Lys 
385                 390                 395             


<210>  207
<211>  398
<212>  PRT
<213>  Homo sapiens

<400>  207

Met Leu Arg Leu Tyr Val Leu Val Met Gly Val Ser Ala Phe Thr Leu 
1               5                   10                  15      


Gln Pro Ala Ala His Thr Gly Ala Ala Arg Ser Cys Arg Phe Arg Gly 
            20                  25                  30          


Arg His Tyr Lys Arg Glu Phe Arg Leu Glu Gly Glu Pro Val Ala Leu 
        35                  40                  45              


Arg Cys Pro Gln Val Pro Tyr Trp Leu Trp Ala Ser Val Ser Pro Arg 
    50                  55                  60                  


Ile Asn Leu Thr Trp His Lys Asn Asp Ser Ala Arg Thr Val Pro Gly 
65                  70                  75                  80  


Glu Glu Glu Thr Arg Met Trp Ala Gln Asp Gly Ala Leu Trp Leu Leu 
                85                  90                  95      


Pro Ala Leu Gln Glu Asp Ser Gly Thr Tyr Val Cys Thr Thr Arg Asn 
            100                 105                 110         


Ala Ser Tyr Cys Asp Lys Met Ser Ile Glu Leu Arg Val Phe Glu Asn 
        115                 120                 125             


Thr Asp Ala Phe Leu Pro Phe Ile Ser Tyr Pro Gln Ile Leu Thr Leu 
    130                 135                 140                 


Ser Thr Ser Gly Val Leu Val Cys Pro Asp Leu Ser Glu Phe Thr Arg 
145                 150                 155                 160 


Asp Lys Thr Asp Val Lys Ile Gln Trp Tyr Lys Asp Ser Leu Leu Leu 
                165                 170                 175     


Asp Lys Asp Asn Glu Lys Phe Leu Ser Val Arg Gly Thr Thr His Leu 
            180                 185                 190         


Leu Val His Asp Val Ala Leu Glu Asp Ala Gly Tyr Tyr Arg Cys Val 
        195                 200                 205             


Leu Thr Phe Ala His Glu Gly Gln Gln Tyr Asn Ile Thr Arg Ser Ile 
    210                 215                 220                 


Glu Leu Arg Ile Lys Lys Lys Lys Glu Glu Thr Ile Pro Val Ile Ile 
225                 230                 235                 240 


Ser Pro Leu Lys Thr Ile Ser Ala Ser Leu Gly Ser Arg Leu Thr Ile 
                245                 250                 255     


Pro Cys Lys Val Phe Leu Gly Thr Gly Thr Pro Leu Thr Thr Met Leu 
            260                 265                 270         


Trp Trp Thr Ala Asn Asp Thr His Ile Glu Ser Ala Tyr Pro Gly Gly 
        275                 280                 285             


Arg Val Thr Glu Gly Pro Arg Gln Glu Tyr Ser Glu Asn Asn Glu Asn 
    290                 295                 300                 


Tyr Ile Glu Val Pro Leu Ile Phe Asp Pro Val Thr Arg Glu Asp Leu 
305                 310                 315                 320 


His Met Asp Phe Lys Cys Val Val His Asn Thr Leu Ser Phe Gln Thr 
                325                 330                 335     


Leu Arg Thr Thr Val Lys Glu Ala Ser Ser Thr Phe Ser Trp Gly Ile 
            340                 345                 350         


Val Leu Ala Pro Leu Ser Leu Ala Phe Leu Val Leu Gly Gly Ile Trp 
        355                 360                 365             


Met His Arg Arg Cys Lys His Arg Thr Gly Lys Ala Asp Gly Leu Thr 
    370                 375                 380                 


Val Leu Trp Pro His His Gln Asp Phe Gln Ser Tyr Pro Lys 
385                 390                 395             


<210>  208
<211>  296
<212>  PRT
<213>  Homo sapiens

<400>  208

Met Leu Arg Leu Tyr Val Leu Val Met Gly Val Ser Ala Phe Thr Leu 
1               5                   10                  15      


Gln Pro Ala Ala His Thr Gly Ala Ala Arg Ser Cys Arg Phe Arg Gly 
            20                  25                  30          


Arg His Tyr Lys Arg Glu Phe Arg Leu Glu Gly Glu Pro Val Ala Leu 
        35                  40                  45              


Arg Cys Pro Gln Val Pro Tyr Trp Leu Trp Ala Ser Val Ser Pro Arg 
    50                  55                  60                  


Ile Asn Leu Thr Trp His Lys Asn Asp Ser Ala Arg Thr Val Pro Gly 
65                  70                  75                  80  


Glu Glu Glu Thr Arg Met Trp Ala Gln Asp Gly Ala Leu Trp Leu Leu 
                85                  90                  95      


Pro Ala Leu Gln Glu Asp Ser Gly Thr Tyr Val Cys Thr Thr Arg Asn 
            100                 105                 110         


Ala Ser Tyr Cys Asp Lys Met Ser Ile Glu Leu Arg Val Phe Glu Asn 
        115                 120                 125             


Thr Asp Ala Phe Leu Pro Phe Ile Ser Tyr Pro Gln Ile Leu Thr Leu 
    130                 135                 140                 


Ser Thr Ser Gly Val Leu Val Cys Pro Asp Leu Ser Glu Phe Thr Arg 
145                 150                 155                 160 


Asp Lys Thr Asp Val Lys Ile Gln Trp Tyr Lys Asp Ser Leu Leu Leu 
                165                 170                 175     


Asp Lys Asp Asn Glu Lys Phe Leu Ser Val Arg Gly Thr Thr His Leu 
            180                 185                 190         


Leu Val His Asp Val Ala Leu Glu Asp Ala Gly Tyr Tyr Arg Cys Val 
        195                 200                 205             


Leu Thr Phe Ala His Glu Gly Gln Gln Tyr Asn Ile Thr Arg Ser Ile 
    210                 215                 220                 


Glu Leu Arg Ile Lys Lys Lys Lys Glu Glu Thr Ile Pro Val Ile Ile 
225                 230                 235                 240 


Ser Pro Leu Lys Thr Ile Ser Ala Ser Leu Gly Ser Arg Leu Thr Ile 
                245                 250                 255     


Pro Cys Lys Val Phe Leu Gly Thr Gly Thr Pro Leu Thr Thr Met Leu 
            260                 265                 270         


Trp Trp Thr Ala Asn Asp Thr His Ile Glu Ser Ala Tyr Pro Gly Gly 
        275                 280                 285             


Arg Val Thr Glu Gly Pro Arg Gln 
    290                 295     


<210>  209
<211>  229
<212>  PRT
<213>  Homo sapiens

<400>  209

Met Leu Arg Leu Tyr Val Leu Val Met Gly Val Ser Ala Phe Thr Leu 
1               5                   10                  15      


Gln Pro Ala Ala His Thr Gly Ala Ala Arg Ser Cys Arg Phe Arg Gly 
            20                  25                  30          


Arg His Tyr Lys Arg Glu Phe Arg Leu Glu Gly Glu Pro Val Ala Leu 
        35                  40                  45              


Arg Cys Pro Gln Val Pro Tyr Trp Leu Trp Ala Ser Val Ser Pro Arg 
    50                  55                  60                  


Ile Asn Leu Thr Trp His Lys Asn Asp Ser Ala Arg Thr Val Pro Gly 
65                  70                  75                  80  


Glu Glu Glu Thr Arg Met Trp Ala Gln Asp Gly Ala Leu Trp Leu Leu 
                85                  90                  95      


Pro Ala Leu Gln Glu Asp Ser Gly Thr Tyr Val Cys Thr Thr Arg Asn 
            100                 105                 110         


Ala Ser Tyr Cys Asp Lys Met Ser Ile Glu Leu Arg Val Phe Glu Asn 
        115                 120                 125             


Thr Asp Ala Phe Leu Pro Phe Ile Ser Tyr Pro Gln Ile Leu Thr Leu 
    130                 135                 140                 


Ser Thr Ser Gly Val Leu Val Cys Pro Asp Leu Ser Glu Phe Thr Arg 
145                 150                 155                 160 


Asp Lys Thr Asp Val Lys Ile Gln Trp Tyr Lys Asp Ser Leu Leu Leu 
                165                 170                 175     


Asp Lys Asp Asn Glu Lys Phe Leu Ser Val Arg Gly Thr Thr His Leu 
            180                 185                 190         


Leu Val His Asp Val Ala Leu Glu Asp Ala Gly Tyr Tyr Arg Cys Val 
        195                 200                 205             


Leu Thr Phe Ala His Glu Gly Gln Gln Tyr Asn Ile Thr Arg Ser Ile 
    210                 215                 220                 


Glu Leu Arg Ile Lys 
225                 


<210>  210
<211>  447
<212>  PRT
<213>  Homo sapiens

<400>  210

Met Lys Val Leu Leu Arg Leu Ile Cys Phe Ile Ala Leu Leu Ile Ser 
1               5                   10                  15      


Ser Leu Glu Ala Asp Lys Cys Lys Glu Arg Glu Glu Lys Ile Ile Leu 
            20                  25                  30          


Val Ser Ser Ala Asn Glu Ile Asp Val Arg Pro Cys Pro Leu Asn Pro 
        35                  40                  45              


Asn Glu His Lys Gly Thr Ile Thr Trp Tyr Lys Asp Asp Ser Lys Thr 
    50                  55                  60                  


Pro Val Ser Thr Glu Gln Ala Ser Arg Ile His Gln His Lys Glu Lys 
65                  70                  75                  80  


Leu Trp Phe Val Pro Ala Lys Val Glu Asp Ser Gly His Tyr Tyr Cys 
                85                  90                  95      


Val Val Arg Asn Ser Ser Tyr Cys Leu Arg Ile Lys Ile Ser Ala Lys 
            100                 105                 110         


Phe Val Glu Asn Glu Pro Asn Leu Cys Tyr Asn Ala Gln Ala Ile Phe 
        115                 120                 125             


Lys Gln Lys Leu Pro Val Ala Gly Asp Gly Gly Leu Val Cys Pro Tyr 
    130                 135                 140                 


Met Glu Phe Phe Lys Asn Glu Asn Asn Glu Leu Pro Lys Leu Gln Trp 
145                 150                 155                 160 


Tyr Lys Asp Cys Lys Pro Leu Leu Leu Asp Asn Ile His Phe Ser Gly 
                165                 170                 175     


Val Lys Asp Arg Leu Ile Val Met Asn Val Ala Glu Lys His Arg Gly 
            180                 185                 190         


Asn Tyr Thr Cys His Ala Ser Tyr Thr Tyr Leu Gly Lys Gln Tyr Pro 
        195                 200                 205             


Ile Thr Arg Val Ile Glu Phe Ile Thr Leu Glu Glu Asn Lys Pro Thr 
    210                 215                 220                 


Arg Pro Val Ile Val Ser Pro Ala Asn Glu Thr Met Glu Val Asp Leu 
225                 230                 235                 240 


Gly Ser Gln Ile Gln Leu Ile Cys Asn Val Thr Gly Gln Leu Ser Asp 
                245                 250                 255     


Ile Ala Tyr Trp Lys Trp Asn Gly Ser Val Ile Asp Glu Asp Asp Pro 
            260                 265                 270         


Val Leu Gly Glu Asp Tyr Tyr Ser Val Glu Asn Pro Ala Asn Lys Arg 
        275                 280                 285             


Arg Ser Thr Leu Ile Thr Val Leu Asn Ile Ser Glu Ile Glu Ser Arg 
    290                 295                 300                 


Phe Tyr Lys His Pro Phe Thr Cys Phe Ala Lys Asn Thr His Gly Ile 
305                 310                 315                 320 


Asp Ala Ala Tyr Ile Gln Leu Ile Tyr Pro Val Thr Asn Phe Gln Lys 
                325                 330                 335     


His Met Ile Gly Ile Cys Val Thr Leu Thr Val Ile Ile Val Cys Ser 
            340                 345                 350         


Val Phe Ile Tyr Lys Ile Phe Lys Ile Asp Ile Val Leu Trp Tyr Arg 
        355                 360                 365             


Asp Ser Cys Tyr Asp Phe Leu Pro Ile Lys Ala Ser Asp Gly Lys Thr 
    370                 375                 380                 


Tyr Asp Ala Tyr Ile Leu Tyr Pro Lys Thr Val Gly Glu Gly Ser Thr 
385                 390                 395                 400 


Ser Asp Cys Asp Ile Phe Val Phe Lys Val Leu Pro Glu Val Leu Glu 
                405                 410                 415     


Lys Gln Cys Gly Tyr Lys Leu Phe Ile Tyr Gly Arg Asp Asp Tyr Val 
            420                 425                 430         


Gly Glu Gly Met Cys Val Met Glu Gln Ser Lys Gly Leu Leu Leu 
        435                 440                 445         


<210>  211
<211>  447
<212>  PRT
<213>  Homo sapiens

<400>  211

Met Lys Val Leu Leu Arg Leu Ile Cys Phe Ile Ala Leu Leu Ile Ser 
1               5                   10                  15      


Ser Leu Glu Ala Asp Lys Cys Lys Glu Arg Glu Glu Lys Ile Ile Leu 
            20                  25                  30          


Val Ser Ser Ala Asn Glu Ile Asp Val Arg Pro Cys Pro Leu Asn Pro 
        35                  40                  45              


Asn Glu His Lys Gly Thr Ile Thr Trp Tyr Lys Asp Asp Ser Lys Thr 
    50                  55                  60                  


Pro Val Ser Thr Glu Gln Ala Ser Arg Ile His Gln His Lys Glu Lys 
65                  70                  75                  80  


Leu Trp Phe Val Pro Ala Lys Val Glu Asp Ser Gly His Tyr Tyr Cys 
                85                  90                  95      


Val Val Arg Asn Ser Ser Tyr Cys Leu Arg Ile Lys Ile Ser Ala Lys 
            100                 105                 110         


Phe Val Glu Asn Glu Pro Asn Leu Cys Tyr Asn Ala Gln Ala Ile Phe 
        115                 120                 125             


Lys Gln Lys Leu Pro Val Ala Gly Asp Gly Gly Leu Val Cys Pro Tyr 
    130                 135                 140                 


Met Glu Phe Phe Lys Asn Glu Asn Asn Glu Leu Pro Lys Leu Gln Trp 
145                 150                 155                 160 


Tyr Lys Asp Cys Lys Pro Leu Leu Leu Asp Asn Ile His Phe Ser Gly 
                165                 170                 175     


Val Lys Asp Arg Leu Ile Val Met Asn Val Ala Glu Lys His Arg Gly 
            180                 185                 190         


Asn Tyr Thr Cys His Ala Ser Tyr Thr Tyr Leu Gly Lys Gln Tyr Pro 
        195                 200                 205             


Ile Thr Arg Val Ile Glu Phe Ile Thr Leu Glu Glu Asn Lys Pro Thr 
    210                 215                 220                 


Arg Pro Val Ile Val Ser Pro Ala Asn Glu Thr Met Glu Val Asp Leu 
225                 230                 235                 240 


Gly Ser Gln Ile Gln Leu Ile Cys Asn Val Thr Gly Gln Leu Ser Asp 
                245                 250                 255     


Ile Ala Tyr Trp Lys Trp Asn Gly Ser Val Ile Asp Glu Asp Asp Pro 
            260                 265                 270         


Val Leu Gly Glu Asp Tyr Tyr Ser Val Glu Asn Pro Ala Asn Lys Arg 
        275                 280                 285             


Arg Ser Thr Leu Ile Thr Val Leu Asn Ile Ser Glu Ile Glu Ser Arg 
    290                 295                 300                 


Phe Tyr Lys His Pro Phe Thr Cys Phe Ala Lys Asn Thr His Gly Ile 
305                 310                 315                 320 


Asp Ala Ala Tyr Ile Gln Leu Ile Tyr Pro Val Thr Asn Phe Gln Lys 
                325                 330                 335     


His Met Ile Gly Ile Cys Val Thr Leu Thr Val Ile Ile Val Cys Ser 
            340                 345                 350         


Val Phe Ile Tyr Lys Ile Phe Lys Ile Asp Ile Val Leu Trp Tyr Arg 
        355                 360                 365             


Asp Ser Cys Tyr Asp Phe Leu Pro Ile Lys Ala Ser Asp Gly Lys Thr 
    370                 375                 380                 


Tyr Asp Ala Tyr Ile Leu Tyr Pro Lys Thr Val Gly Glu Gly Ser Thr 
385                 390                 395                 400 


Ser Asp Cys Asp Ile Phe Val Phe Lys Val Leu Pro Glu Val Leu Glu 
                405                 410                 415     


Lys Gln Cys Gly Tyr Lys Leu Phe Ile Tyr Gly Arg Asp Asp Tyr Val 
            420                 425                 430         


Gly Glu Gly Met Cys Val Met Glu Gln Ser Lys Gly Leu Leu Leu 
        435                 440                 445         


<210>  212
<211>  173
<212>  PRT
<213>  Homo sapiens

<400>  212

Met Lys Val Leu Leu Arg Leu Ile Cys Phe Ile Ala Leu Leu Ile Ser 
1               5                   10                  15      


Ser Leu Glu Ala Asp Lys Cys Lys Glu Arg Glu Glu Lys Ile Ile Leu 
            20                  25                  30          


Val Ser Ser Ala Asn Glu Ile Asp Val Arg Pro Cys Pro Leu Asn Pro 
        35                  40                  45              


Asn Glu His Lys Gly Thr Ile Thr Trp Tyr Lys Asp Asp Ser Lys Thr 
    50                  55                  60                  


Pro Val Ser Thr Glu Gln Ala Ser Arg Ile His Gln His Lys Glu Lys 
65                  70                  75                  80  


Leu Trp Phe Val Pro Ala Lys Val Glu Asp Ser Gly His Tyr Tyr Cys 
                85                  90                  95      


Val Val Arg Asn Ser Ser Tyr Cys Leu Arg Ile Lys Ile Ser Ala Lys 
            100                 105                 110         


Phe Val Glu Asn Glu Pro Asn Leu Cys Tyr Asn Ala Gln Ala Ile Phe 
        115                 120                 125             


Lys Gln Lys Leu Pro Val Ala Gly Asp Gly Gly Leu Val Cys Pro Tyr 
    130                 135                 140                 


Met Glu Phe Phe Lys Asn Glu Asn Asn Glu Leu Pro Lys Leu Gln Trp 
145                 150                 155                 160 


Tyr Lys Val Ala Val Ser Arg Val Trp Ala Thr Ala Leu 
                165                 170             


<210>  213
<211>  538
<212>  PRT
<213>  Homo sapiens

<400>  213

Met Lys Val Leu Leu Arg Leu Ile Cys Phe Ile Ala Leu Leu Ile Ser 
1               5                   10                  15      


Ser Leu Glu Ala Asp Lys Cys Lys Glu Arg Glu Glu Lys Ile Ile Leu 
            20                  25                  30          


Val Ser Ser Ala Asn Glu Ile Asp Val Arg Pro Cys Pro Leu Asn Pro 
        35                  40                  45              


Asn Glu His Lys Gly Thr Ile Thr Trp Tyr Lys Asp Asp Ser Lys Thr 
    50                  55                  60                  


Pro Val Ser Thr Glu Gln Ala Ser Arg Ile His Gln His Lys Glu Lys 
65                  70                  75                  80  


Leu Trp Phe Val Pro Ala Lys Val Glu Asp Ser Gly His Tyr Tyr Cys 
                85                  90                  95      


Val Val Arg Asn Ser Ser Tyr Cys Leu Arg Ile Lys Ile Ser Ala Lys 
            100                 105                 110         


Phe Val Glu Asn Glu Pro Asn Leu Cys Tyr Asn Ala Gln Ala Ile Phe 
        115                 120                 125             


Lys Gln Lys Leu Pro Val Ala Gly Asp Gly Gly Leu Val Cys Pro Tyr 
    130                 135                 140                 


Met Glu Phe Phe Lys Asn Glu Asn Asn Glu Leu Pro Lys Leu Gln Trp 
145                 150                 155                 160 


Tyr Lys Asp Cys Lys Pro Leu Leu Leu Asp Asn Ile His Phe Ser Gly 
                165                 170                 175     


Val Lys Asp Arg Leu Ile Val Met Asn Val Ala Glu Lys His Arg Gly 
            180                 185                 190         


Asn Tyr Thr Cys His Ala Ser Tyr Thr Tyr Leu Gly Lys Gln Tyr Pro 
        195                 200                 205             


Ile Thr Arg Val Ile Glu Phe Ile Thr Leu Glu Glu Asn Lys Pro Thr 
    210                 215                 220                 


Arg Pro Val Ile Val Ser Pro Ala Asn Glu Thr Met Glu Val Asp Leu 
225                 230                 235                 240 


Gly Ser Gln Ile Gln Leu Ile Cys Asn Val Thr Gly Gln Leu Ser Asp 
                245                 250                 255     


Ile Ala Tyr Trp Lys Trp Asn Gly Ser Val Ile Asp Glu Asp Asp Pro 
            260                 265                 270         


Val Leu Gly Glu Asp Tyr Tyr Ser Val Glu Asn Pro Ala Asn Lys Arg 
        275                 280                 285             


Arg Ser Thr Leu Ile Thr Val Leu Asn Ile Ser Glu Ile Glu Ser Arg 
    290                 295                 300                 


Phe Tyr Lys His Pro Phe Thr Cys Phe Ala Lys Asn Thr His Gly Ile 
305                 310                 315                 320 


Asp Ala Ala Tyr Ile Gln Leu Ile Tyr Pro Val Thr Asn Phe Gln Lys 
                325                 330                 335     


His Met Ile Gly Ile Cys Val Thr Leu Thr Val Ile Ile Val Cys Ser 
            340                 345                 350         


Val Phe Ile Tyr Lys Ile Phe Lys Ile Asp Ile Val Leu Trp Tyr Arg 
        355                 360                 365             


Asp Ser Cys Tyr Asp Phe Leu Pro Ile Lys Val Leu Pro Glu Val Leu 
    370                 375                 380                 


Glu Lys Gln Cys Gly Tyr Lys Leu Phe Ile Tyr Gly Arg Asp Asp Tyr 
385                 390                 395                 400 


Val Gly Glu Asp Ile Val Glu Val Ile Asn Glu Asn Val Lys Lys Ser 
                405                 410                 415     


Arg Arg Leu Ile Ile Ile Leu Val Arg Glu Thr Ser Gly Phe Ser Trp 
            420                 425                 430         


Leu Gly Gly Ser Ser Glu Glu Gln Ile Ala Met Tyr Asn Ala Leu Val 
        435                 440                 445             


Gln Asp Gly Ile Lys Val Val Leu Leu Glu Leu Glu Lys Ile Gln Asp 
    450                 455                 460                 


Tyr Glu Lys Met Pro Glu Ser Ile Lys Phe Ile Lys Gln Lys His Gly 
465                 470                 475                 480 


Ala Ile Arg Trp Ser Gly Asp Phe Thr Gln Gly Pro Gln Ser Ala Lys 
                485                 490                 495     


Thr Arg Phe Trp Lys Asn Val Arg Tyr His Met Pro Val Gln Arg Arg 
            500                 505                 510         


Ser Pro Ser Ser Lys His Gln Leu Leu Ser Pro Ala Thr Lys Glu Lys 
        515                 520                 525             


Leu Gln Arg Glu Ala His Val Pro Leu Gly 
    530                 535             


<210>  214
<211>  569
<212>  PRT
<213>  Homo sapiens

<400>  214

Met Lys Val Leu Leu Arg Leu Ile Cys Phe Ile Ala Leu Leu Ile Ser 
1               5                   10                  15      


Ser Leu Glu Ala Asp Lys Cys Lys Glu Arg Glu Glu Lys Ile Ile Leu 
            20                  25                  30          


Val Ser Ser Ala Asn Glu Ile Asp Val Arg Pro Cys Pro Leu Asn Pro 
        35                  40                  45              


Asn Glu His Lys Gly Thr Ile Thr Trp Tyr Lys Asp Asp Ser Lys Thr 
    50                  55                  60                  


Pro Val Ser Thr Glu Gln Ala Ser Arg Ile His Gln His Lys Glu Lys 
65                  70                  75                  80  


Leu Trp Phe Val Pro Ala Lys Val Glu Asp Ser Gly His Tyr Tyr Cys 
                85                  90                  95      


Val Val Arg Asn Ser Ser Tyr Cys Leu Arg Ile Lys Ile Ser Ala Lys 
            100                 105                 110         


Phe Val Glu Asn Glu Pro Asn Leu Cys Tyr Asn Ala Gln Ala Ile Phe 
        115                 120                 125             


Lys Gln Lys Leu Pro Val Ala Gly Asp Gly Gly Leu Val Cys Pro Tyr 
    130                 135                 140                 


Met Glu Phe Phe Lys Asn Glu Asn Asn Glu Leu Pro Lys Leu Gln Trp 
145                 150                 155                 160 


Tyr Lys Asp Cys Lys Pro Leu Leu Leu Asp Asn Ile His Phe Ser Gly 
                165                 170                 175     


Val Lys Asp Arg Leu Ile Val Met Asn Val Ala Glu Lys His Arg Gly 
            180                 185                 190         


Asn Tyr Thr Cys His Ala Ser Tyr Thr Tyr Leu Gly Lys Gln Tyr Pro 
        195                 200                 205             


Ile Thr Arg Val Ile Glu Phe Ile Thr Leu Glu Glu Asn Lys Pro Thr 
    210                 215                 220                 


Arg Pro Val Ile Val Ser Pro Ala Asn Glu Thr Met Glu Val Asp Leu 
225                 230                 235                 240 


Gly Ser Gln Ile Gln Leu Ile Cys Asn Val Thr Gly Gln Leu Ser Asp 
                245                 250                 255     


Ile Ala Tyr Trp Lys Trp Asn Gly Ser Val Ile Asp Glu Asp Asp Pro 
            260                 265                 270         


Val Leu Gly Glu Asp Tyr Tyr Ser Val Glu Asn Pro Ala Asn Lys Arg 
        275                 280                 285             


Arg Ser Thr Leu Ile Thr Val Leu Asn Ile Ser Glu Ile Glu Ser Arg 
    290                 295                 300                 


Phe Tyr Lys His Pro Phe Thr Cys Phe Ala Lys Asn Thr His Gly Ile 
305                 310                 315                 320 


Asp Ala Ala Tyr Ile Gln Leu Ile Tyr Pro Val Thr Asn Phe Gln Lys 
                325                 330                 335     


His Met Ile Gly Ile Cys Val Thr Leu Thr Val Ile Ile Val Cys Ser 
            340                 345                 350         


Val Phe Ile Tyr Lys Ile Phe Lys Ile Asp Ile Val Leu Trp Tyr Arg 
        355                 360                 365             


Asp Ser Cys Tyr Asp Phe Leu Pro Ile Lys Ala Ser Asp Gly Lys Thr 
    370                 375                 380                 


Tyr Asp Ala Tyr Ile Leu Tyr Pro Lys Thr Val Gly Glu Gly Ser Thr 
385                 390                 395                 400 


Ser Asp Cys Asp Ile Phe Val Phe Lys Val Leu Pro Glu Val Leu Glu 
                405                 410                 415     


Lys Gln Cys Gly Tyr Lys Leu Phe Ile Tyr Gly Arg Asp Asp Tyr Val 
            420                 425                 430         


Gly Glu Asp Ile Val Glu Val Ile Asn Glu Asn Val Lys Lys Ser Arg 
        435                 440                 445             


Arg Leu Ile Ile Ile Leu Val Arg Glu Thr Ser Gly Phe Ser Trp Leu 
    450                 455                 460                 


Gly Gly Ser Ser Glu Glu Gln Ile Ala Met Tyr Asn Ala Leu Val Gln 
465                 470                 475                 480 


Asp Gly Ile Lys Val Val Leu Leu Glu Leu Glu Lys Ile Gln Asp Tyr 
                485                 490                 495     


Glu Lys Met Pro Glu Ser Ile Lys Phe Ile Lys Gln Lys His Gly Ala 
            500                 505                 510         


Ile Arg Trp Ser Gly Asp Phe Thr Gln Gly Pro Gln Ser Ala Lys Thr 
        515                 520                 525             


Arg Phe Trp Lys Asn Val Arg Tyr His Met Pro Val Gln Arg Arg Ser 
    530                 535                 540                 


Pro Ser Ser Lys His Gln Leu Leu Ser Pro Ala Thr Lys Glu Lys Leu 
545                 550                 555                 560 


Gln Arg Glu Ala His Val Pro Leu Gly 
                565                 


<210>  215
<211>  119
<212>  PRT
<213>  Homo sapiens

<400>  215

Met Lys Val Leu Leu Arg Leu Ile Cys Phe Ile Ala Leu Leu Ile Ser 
1               5                   10                  15      


Ser Leu Glu Ala Asp Lys Cys Lys Glu Arg Glu Glu Lys Ile Ile Leu 
            20                  25                  30          


Val Ser Ser Ala Asn Glu Ile Asp Val Arg Pro Cys Pro Leu Asn Pro 
        35                  40                  45              


Asn Glu His Lys Gly Thr Ile Thr Trp Tyr Lys Asp Asp Ser Lys Thr 
    50                  55                  60                  


Pro Val Ser Thr Glu Gln Ala Ser Arg Ile His Gln His Lys Glu Lys 
65                  70                  75                  80  


Leu Trp Phe Val Pro Ala Lys Val Glu Asp Ser Gly His Tyr Tyr Cys 
                85                  90                  95      


Val Val Arg Ile Ala Asn Leu Tyr Phe Leu Thr Ile Tyr Thr Leu Val 
            100                 105                 110         


Glu Ser Lys Ile Gly Ser Ser 
        115                 


<210>  216
<211>  124
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  216

Xaa Lys Cys Lys Glu Arg Glu Glu Lys Ile Ile Leu Val Ser Ser Ala 
1               5                   10                  15      


Asn Glu Ile Asp Val Arg Pro Cys Pro Leu Asn Pro Asn Glu His Lys 
            20                  25                  30          


Gly Thr Ile Thr Trp Tyr Lys Asp Asp Ser Lys Thr Pro Val Ser Thr 
        35                  40                  45              


Glu Gln Ala Ser Arg Ile His Gln His Lys Glu Lys Leu Trp Phe Val 
    50                  55                  60                  


Pro Ala Lys Val Glu Asp Ser Gly His Tyr Tyr Cys Val Glu Thr Glu 
65                  70                  75                  80  


Asp Leu Cys Ala Leu Ile Trp Ser Phe Leu Lys Met Lys Ile Met Ser 
                85                  90                  95      


Tyr Leu Asn Tyr Ser Gly Ile Arg Ile Ala Asn Leu Tyr Phe Leu Thr 
            100                 105                 110         


Ile Tyr Thr Leu Val Glu Ser Lys Ile Gly Ser Ser 
        115                 120                 


<210>  217
<211>  447
<212>  PRT
<213>  Homo sapiens

<400>  217

Met Lys Val Leu Leu Arg Leu Ile Cys Phe Ile Ala Leu Leu Ile Ser 
1               5                   10                  15      


Ser Leu Glu Ala Asp Lys Cys Lys Glu Arg Glu Glu Lys Ile Ile Leu 
            20                  25                  30          


Val Ser Ser Ala Asn Glu Ile Asp Val Arg Pro Cys Pro Leu Asn Pro 
        35                  40                  45              


Asn Glu His Lys Gly Thr Ile Thr Trp Tyr Lys Asp Asp Ser Lys Thr 
    50                  55                  60                  


Pro Val Ser Thr Glu Gln Ala Ser Arg Ile His Gln His Lys Glu Lys 
65                  70                  75                  80  


Leu Trp Phe Val Pro Ala Lys Val Glu Asp Ser Gly His Tyr Tyr Cys 
                85                  90                  95      


Val Val Arg Asn Ser Ser Tyr Cys Leu Arg Ile Lys Ile Ser Ala Lys 
            100                 105                 110         


Phe Val Glu Asn Glu Pro Asn Leu Cys Tyr Asn Ala Gln Ala Ile Phe 
        115                 120                 125             


Lys Gln Lys Leu Pro Val Ala Gly Asp Gly Gly Leu Val Cys Pro Tyr 
    130                 135                 140                 


Met Glu Phe Phe Lys Asn Glu Asn Asn Glu Leu Pro Lys Leu Gln Trp 
145                 150                 155                 160 


Tyr Lys Asp Cys Lys Pro Leu Leu Leu Asp Asn Ile His Phe Ser Gly 
                165                 170                 175     


Val Lys Asp Arg Leu Ile Val Met Asn Val Ala Glu Lys His Arg Gly 
            180                 185                 190         


Asn Tyr Thr Cys His Ala Ser Tyr Thr Tyr Leu Gly Lys Gln Tyr Pro 
        195                 200                 205             


Ile Thr Arg Val Ile Glu Phe Ile Thr Leu Glu Glu Asn Lys Pro Thr 
    210                 215                 220                 


Arg Pro Val Ile Val Ser Pro Ala Asn Glu Thr Met Glu Val Asp Leu 
225                 230                 235                 240 


Gly Ser Gln Ile Gln Leu Ile Cys Asn Val Thr Gly Gln Leu Ser Asp 
                245                 250                 255     


Ile Ala Tyr Trp Lys Trp Asn Gly Ser Val Ile Asp Glu Asp Asp Pro 
            260                 265                 270         


Val Leu Gly Glu Asp Tyr Tyr Ser Val Glu Asn Pro Ala Asn Lys Arg 
        275                 280                 285             


Arg Ser Thr Leu Ile Thr Val Leu Asn Ile Ser Glu Ile Glu Ser Arg 
    290                 295                 300                 


Phe Tyr Lys His Pro Phe Thr Cys Phe Ala Lys Asn Thr His Gly Ile 
305                 310                 315                 320 


Asp Ala Ala Tyr Ile Gln Leu Ile Tyr Pro Val Thr Asn Phe Gln Lys 
                325                 330                 335     


His Met Ile Gly Ile Cys Val Thr Leu Thr Val Ile Ile Val Cys Ser 
            340                 345                 350         


Val Phe Ile Tyr Lys Ile Phe Lys Ile Asp Ile Val Leu Trp Tyr Arg 
        355                 360                 365             


Asp Ser Cys Tyr Asp Phe Leu Pro Ile Lys Ala Ser Asp Gly Lys Thr 
    370                 375                 380                 


Tyr Asp Ala Tyr Ile Leu Tyr Pro Lys Thr Val Gly Glu Gly Ser Thr 
385                 390                 395                 400 


Ser Asp Cys Asp Ile Phe Val Phe Lys Val Leu Pro Glu Val Leu Glu 
                405                 410                 415     


Lys Gln Cys Gly Tyr Lys Leu Phe Ile Tyr Gly Arg Asp Asp Tyr Val 
            420                 425                 430         


Gly Glu Gly Met Cys Val Met Glu Gln Ser Lys Gly Leu Leu Leu 
        435                 440                 445         


<210>  218
<211>  298
<212>  PRT
<213>  Homo sapiens

<400>  218

Met Glu Phe Phe Lys Asn Glu Asn Asn Glu Leu Pro Lys Leu Gln Trp 
1               5                   10                  15      


Tyr Lys Asp Cys Lys Pro Leu Leu Leu Asp Asn Ile His Phe Ser Gly 
            20                  25                  30          


Val Lys Asp Arg Leu Ile Val Met Asn Val Ala Glu Lys His Arg Gly 
        35                  40                  45              


Asn Tyr Thr Cys His Ala Ser Tyr Thr Tyr Leu Gly Lys Gln Tyr Pro 
    50                  55                  60                  


Ile Thr Arg Val Ile Glu Phe Ile Thr Leu Glu Glu Asn Lys Pro Thr 
65                  70                  75                  80  


Arg Pro Val Ile Val Ser Pro Ala Asn Glu Thr Met Glu Val Asp Leu 
                85                  90                  95      


Gly Ser Gln Ile Gln Leu Ile Cys Asn Val Thr Gly Gln Leu Ser Asp 
            100                 105                 110         


Ile Ala Tyr Trp Lys Trp Asn Gly Ser Val Ile Asp Glu Asp Asp Pro 
        115                 120                 125             


Val Leu Gly Glu Asp Tyr Tyr Ser Val Glu Asn Pro Ala Asn Lys Arg 
    130                 135                 140                 


Arg Ser Thr Leu Ile Thr Val Leu Asn Ile Ser Glu Ile Glu Ser Arg 
145                 150                 155                 160 


Phe Tyr Lys His Pro Phe Thr Cys Phe Ala Lys Asn Thr His Gly Ile 
                165                 170                 175     


Asp Ala Ala Tyr Ile Gln Leu Ile Tyr Pro Val Thr Asn Phe Gln Lys 
            180                 185                 190         


His Met Ile Gly Ile Cys Val Thr Leu Thr Val Ile Ile Val Cys Ser 
        195                 200                 205             


Val Phe Ile Tyr Lys Ile Phe Lys Ile Asp Ile Val Leu Trp Tyr Arg 
    210                 215                 220                 


Asp Ser Cys Tyr Asp Phe Leu Pro Ile Lys Ala Ser Asp Gly Lys Thr 
225                 230                 235                 240 


Tyr Asp Ala Tyr Ile Leu Tyr Pro Lys Thr Val Gly Glu Gly Ser Thr 
                245                 250                 255     


Ser Asp Cys Asp Ile Phe Val Phe Lys Val Leu Pro Glu Val Leu Glu 
            260                 265                 270         


Lys Gln Cys Gly Tyr Lys Leu Phe Ile Tyr Gly Arg Asp Asp Tyr Val 
        275                 280                 285             


Gly Glu Asp Ile Val Glu Val Ile Asn Glu 
    290                 295             


<210>  219
<211>  182
<212>  PRT
<213>  Homo sapiens

<400>  219

Met Lys Val Leu Leu Arg Leu Ile Cys Phe Ile Ala Leu Leu Ile Ser 
1               5                   10                  15      


Ser Leu Glu Ala Asp Lys Cys Lys Glu Arg Glu Glu Lys Ile Ile Leu 
            20                  25                  30          


Val Ser Ser Ala Asn Glu Ile Asp Val Arg Pro Cys Pro Leu Asn Pro 
        35                  40                  45              


Asn Glu His Lys Gly Thr Ile Thr Trp Tyr Lys Asp Asp Ser Lys Thr 
    50                  55                  60                  


Pro Val Ser Thr Glu Gln Ala Ser Arg Ile His Gln His Lys Glu Lys 
65                  70                  75                  80  


Leu Trp Phe Val Pro Ala Lys Val Glu Asp Ser Gly His Tyr Tyr Cys 
                85                  90                  95      


Val Val Arg Asn Ser Ser Tyr Cys Leu Arg Ile Lys Ile Ser Ala Lys 
            100                 105                 110         


Phe Val Glu Asn Glu Pro Asn Leu Cys Tyr Asn Ala Gln Ala Ile Phe 
        115                 120                 125             


Lys Gln Lys Leu Pro Val Ala Gly Asp Gly Gly Leu Val Cys Pro Tyr 
    130                 135                 140                 


Met Glu Phe Phe Lys Asn Glu Asn Asn Glu Leu Pro Lys Leu Gln Trp 
145                 150                 155                 160 


Tyr Lys Asp Cys Lys Pro Leu Leu Leu Asp Asn Ile His Phe Ser Gly 
                165                 170                 175     


Val Lys Asp Arg Leu Ile 
            180         


<210>  220
<211>  114
<212>  PRT
<213>  Homo sapiens

<400>  220

Met Lys Val Leu Leu Arg Leu Ile Cys Phe Ile Ala Leu Leu Ile Ser 
1               5                   10                  15      


Ser Leu Glu Ala Asp Lys Cys Lys Glu Arg Glu Glu Lys Ile Ile Leu 
            20                  25                  30          


Val Ser Ser Ala Asn Glu Ile Asp Val Arg Pro Cys Pro Leu Asn Pro 
        35                  40                  45              


Asn Glu His Lys Gly Thr Ile Thr Trp Tyr Lys Asp Asp Ser Lys Thr 
    50                  55                  60                  


Pro Val Ser Thr Glu Gln Ala Ser Arg Ile His Gln His Lys Glu Lys 
65                  70                  75                  80  


Leu Trp Phe Val Pro Ala Lys Val Glu Asp Ser Gly His Tyr Tyr Cys 
                85                  90                  95      


Val Val Arg Asn Ser Ser Tyr Cys Leu Arg Ile Lys Ile Ser Ala Lys 
            100                 105                 110         


Phe Val 
        


<210>  221
<211>  106
<212>  PRT
<213>  Homo sapiens

<400>  221

Met Lys Val Leu Leu Arg Leu Ile Cys Phe Ile Ala Leu Leu Ile Ser 
1               5                   10                  15      


Ser Leu Glu Ala Asp Lys Cys Lys Glu Arg Glu Glu Lys Ile Ile Leu 
            20                  25                  30          


Val Ser Ser Ala Asn Glu Ile Asp Val Arg Pro Cys Pro Leu Asn Pro 
        35                  40                  45              


Asn Glu His Lys Gly Thr Ile Thr Trp Tyr Lys Asp Asp Ser Lys Thr 
    50                  55                  60                  


Pro Val Ser Thr Glu Gln Ala Ser Arg Ile His Gln His Lys Glu Lys 
65                  70                  75                  80  


Leu Trp Phe Val Pro Ala Lys Val Glu Asp Ser Gly His Tyr Tyr Cys 
                85                  90                  95      


Val Val Arg Asn Ser Ser Tyr Cys Leu Arg 
            100                 105     


<210>  222
<211>  80
<212>  PRT
<213>  Homo sapiens

<400>  222

Met Lys Val Leu Leu Arg Leu Ile Cys Phe Ile Ala Leu Leu Ile Ser 
1               5                   10                  15      


Ser Leu Glu Ala Asp Lys Cys Lys Glu Arg Glu Glu Lys Ile Ile Leu 
            20                  25                  30          


Val Ser Ser Ala Asn Glu Ile Asp Val Arg Pro Cys Pro Leu Asn Pro 
        35                  40                  45              


Asn Glu His Lys Gly Thr Ile Thr Trp Tyr Lys Asp Asp Ser Lys Thr 
    50                  55                  60                  


Pro Val Ser Thr Glu Gln Ala Ser Arg Ile His Gln His Lys Glu Lys 
65                  70                  75                  80  


<210>  223
<211>  575
<212>  PRT
<213>  Homo sapiens

<400>  223

Met Trp Ser Leu Leu Leu Cys Gly Leu Ser Ile Ala Leu Pro Leu Ser 
1               5                   10                  15      


Val Thr Ala Asp Gly Cys Lys Asp Ile Phe Met Lys Asn Glu Ile Leu 
            20                  25                  30          


Ser Ala Ser Gln Pro Phe Ala Phe Asn Cys Thr Phe Pro Pro Ile Thr 
        35                  40                  45              


Ser Gly Glu Val Ser Val Thr Trp Tyr Lys Asn Ser Ser Lys Ile Pro 
    50                  55                  60                  


Val Ser Lys Ile Ile Gln Ser Arg Ile His Gln Asp Glu Thr Trp Ile 
65                  70                  75                  80  


Leu Phe Leu Pro Met Glu Trp Gly Asp Ser Gly Val Tyr Gln Cys Val 
                85                  90                  95      


Ile Lys Gly Arg Asp Ser Cys His Arg Ile His Val Asn Leu Thr Val 
            100                 105                 110         


Phe Glu Lys His Trp Cys Asp Thr Ser Ile Gly Gly Leu Pro Asn Leu 
        115                 120                 125             


Ser Asp Glu Tyr Lys Gln Ile Leu His Leu Gly Lys Asp Asp Ser Leu 
    130                 135                 140                 


Thr Cys His Leu His Phe Pro Lys Ser Cys Val Leu Gly Pro Ile Lys 
145                 150                 155                 160 


Trp Tyr Lys Asp Cys Asn Glu Ile Lys Gly Glu Arg Phe Thr Val Leu 
                165                 170                 175     


Glu Thr Arg Leu Leu Val Ser Asn Val Ser Ala Glu Asp Arg Gly Asn 
            180                 185                 190         


Tyr Ala Cys Gln Ala Ile Leu Thr His Ser Gly Lys Gln Tyr Glu Val 
        195                 200                 205             


Leu Asn Gly Ile Thr Val Ser Ile Thr Glu Arg Ala Gly Tyr Gly Gly 
    210                 215                 220                 


Ser Val Pro Lys Ile Ile Tyr Pro Lys Asn His Ser Ile Glu Val Gln 
225                 230                 235                 240 


Leu Gly Thr Thr Leu Ile Val Asp Cys Asn Val Thr Asp Thr Lys Asp 
                245                 250                 255     


Asn Thr Asn Leu Arg Cys Trp Arg Val Asn Asn Thr Leu Val Asp Asp 
            260                 265                 270         


Tyr Tyr Asp Glu Ser Lys Arg Ile Arg Glu Gly Val Glu Thr His Val 
        275                 280                 285             


Ser Phe Arg Glu His Asn Leu Tyr Thr Val Asn Ile Thr Phe Leu Glu 
    290                 295                 300                 


Val Lys Met Glu Asp Tyr Gly Leu Pro Phe Met Cys His Ala Gly Val 
305                 310                 315                 320 


Ser Thr Ala Tyr Ile Ile Leu Gln Leu Pro Ala Pro Asp Phe Arg Ala 
                325                 330                 335     


Tyr Leu Ile Gly Gly Leu Ile Ala Leu Val Ala Val Ala Val Ser Val 
            340                 345                 350         


Val Tyr Ile Tyr Asn Ile Phe Lys Ile Asp Ile Val Leu Trp Tyr Arg 
        355                 360                 365             


Ser Ala Phe His Ser Thr Glu Thr Ile Val Asp Gly Lys Leu Tyr Asp 
    370                 375                 380                 


Ala Tyr Val Leu Tyr Pro Lys Pro His Lys Glu Ser Gln Arg His Ala 
385                 390                 395                 400 


Val Asp Ala Leu Val Leu Asn Ile Leu Pro Glu Val Leu Glu Arg Gln 
                405                 410                 415     


Cys Gly Tyr Lys Leu Phe Ile Phe Gly Arg Asp Glu Phe Pro Gly Gln 
            420                 425                 430         


Ala Val Ala Asn Val Ile Asp Glu Asn Val Lys Leu Cys Arg Arg Leu 
        435                 440                 445             


Ile Val Ile Val Val Pro Glu Ser Leu Gly Phe Gly Leu Leu Lys Asn 
    450                 455                 460                 


Leu Ser Glu Glu Gln Ile Ala Val Tyr Ser Ala Leu Ile Gln Asp Gly 
465                 470                 475                 480 


Met Lys Val Ile Leu Ile Glu Leu Glu Lys Ile Glu Asp Tyr Thr Val 
                485                 490                 495     


Met Pro Glu Ser Ile Gln Tyr Ile Lys Gln Lys His Gly Ala Ile Arg 
            500                 505                 510         


Trp His Gly Asp Phe Thr Glu Gln Ser Gln Cys Met Lys Thr Lys Phe 
        515                 520                 525             


Trp Lys Thr Val Arg Tyr His Met Pro Pro Arg Arg Cys Arg Pro Phe 
    530                 535                 540                 


Pro Pro Val Gln Leu Leu Gln His Thr Pro Cys Tyr Arg Thr Ala Gly 
545                 550                 555                 560 


Pro Glu Leu Gly Ser Arg Arg Lys Lys Cys Thr Leu Thr Thr Gly 
                565                 570                 575 


<210>  224
<211>  172
<212>  PRT
<213>  Homo sapiens

<400>  224

Met Trp Ser Leu Leu Leu Cys Gly Leu Ser Ile Ala Leu Pro Leu Ser 
1               5                   10                  15      


Val Thr Ala Asp Gly Cys Lys Asp Ile Phe Met Lys Asn Glu Ile Leu 
            20                  25                  30          


Ser Ala Ser Gln Pro Phe Ala Phe Asn Cys Thr Phe Pro Pro Ile Thr 
        35                  40                  45              


Ser Gly Glu Val Ser Val Thr Trp Tyr Lys Asn Ser Ser Lys Ile Pro 
    50                  55                  60                  


Val Ser Lys Ile Ile Gln Ser Arg Ile His Gln Asp Glu Thr Trp Ile 
65                  70                  75                  80  


Leu Phe Leu Pro Met Glu Trp Gly Asp Ser Gly Val Tyr Gln Cys Val 
                85                  90                  95      


Ile Lys Gly Arg Asp Ser Cys His Arg Ile His Val Asn Leu Thr Val 
            100                 105                 110         


Phe Glu Lys His Trp Cys Asp Thr Ser Ile Gly Gly Leu Pro Asn Leu 
        115                 120                 125             


Ser Asp Glu Tyr Lys Gln Ile Leu His Leu Gly Lys Asp Asp Ser Leu 
    130                 135                 140                 


Thr Cys His Leu His Phe Pro Lys Ser Cys Val Leu Gly Pro Ile Lys 
145                 150                 155                 160 


Trp Tyr Lys Asp Cys Asn Glu Ile Lys Gly Glu Arg 
                165                 170         


<210>  225
<211>  457
<212>  PRT
<213>  Homo sapiens

<400>  225

Met Thr Gly Leu Val Ser Leu Ser Tyr Phe Pro Leu Ser Thr Arg Ser 
1               5                   10                  15      


Cys Ala Leu Gln Ser Cys Ser Pro Val Trp Gly Cys Gly Pro Cys Cys 
            20                  25                  30          


Ser Ala Gly Cys Pro Ser Pro Phe His Cys Leu Ser Gln Gln Asp Cys 
        35                  40                  45              


Asn Glu Ile Lys Gly Glu Arg Phe Thr Val Leu Glu Thr Arg Leu Leu 
    50                  55                  60                  


Val Ser Asn Val Ser Ala Glu Asp Arg Gly Asn Tyr Ala Cys Gln Ala 
65                  70                  75                  80  


Ile Leu Thr His Ser Gly Lys Gln Tyr Glu Val Leu Asn Gly Ile Thr 
                85                  90                  95      


Val Ser Ile Lys Arg Ala Gly Tyr Gly Gly Ser Val Pro Lys Ile Ile 
            100                 105                 110         


Tyr Pro Lys Asn His Ser Ile Glu Val Gln Leu Gly Thr Thr Leu Ile 
        115                 120                 125             


Val Asp Cys Asn Val Thr Asp Thr Lys Asp Asn Thr Asn Leu Arg Cys 
    130                 135                 140                 


Trp Arg Val Asn Asn Thr Leu Val Asp Asp Tyr Tyr Asp Glu Ser Lys 
145                 150                 155                 160 


Arg Ile Arg Glu Gly Val Glu Thr His Val Ser Phe Arg Glu His Asn 
                165                 170                 175     


Leu Tyr Thr Val Asn Ile Thr Phe Leu Glu Val Lys Met Glu Asp Tyr 
            180                 185                 190         


Gly Leu Pro Phe Met Cys His Ala Gly Val Ser Thr Ala Tyr Ile Ile 
        195                 200                 205             


Leu Gln Leu Pro Ala Pro Asp Phe Arg Ala Tyr Leu Ile Gly Gly Leu 
    210                 215                 220                 


Ile Ala Leu Val Ala Val Ala Val Ser Val Val Tyr Ile Tyr Asn Ile 
225                 230                 235                 240 


Phe Lys Ile Asp Ile Val Leu Trp Tyr Arg Ser Ala Phe His Ser Thr 
                245                 250                 255     


Glu Thr Ile Val Asp Gly Lys Leu Tyr Asp Ala Tyr Val Leu Tyr Pro 
            260                 265                 270         


Lys Pro His Lys Glu Ser Gln Arg His Ala Val Asp Ala Leu Val Leu 
        275                 280                 285             


Asn Ile Leu Pro Glu Val Leu Glu Arg Gln Cys Gly Tyr Lys Leu Phe 
    290                 295                 300                 


Ile Phe Gly Arg Asp Glu Phe Pro Gly Gln Ala Val Ala Asn Val Ile 
305                 310                 315                 320 


Asp Glu Asn Val Lys Leu Cys Arg Arg Leu Ile Val Ile Val Val Pro 
                325                 330                 335     


Glu Ser Leu Gly Phe Gly Leu Leu Lys Asn Leu Ser Glu Glu Gln Ile 
            340                 345                 350         


Ala Val Tyr Ser Ala Leu Ile Gln Asp Gly Met Lys Val Ile Leu Ile 
        355                 360                 365             


Glu Leu Glu Lys Ile Glu Asp Tyr Thr Val Met Pro Glu Ser Ile Gln 
    370                 375                 380                 


Tyr Ile Lys Gln Lys His Gly Ala Ile Arg Trp His Gly Asp Phe Thr 
385                 390                 395                 400 


Glu Gln Ser Gln Cys Met Lys Thr Lys Phe Trp Lys Thr Val Arg Tyr 
                405                 410                 415     


His Met Pro Pro Arg Arg Cys Arg Pro Phe Pro Pro Val Gln Leu Leu 
            420                 425                 430         


Gln His Thr Pro Cys Tyr Arg Thr Ala Gly Pro Glu Leu Gly Ser Arg 
        435                 440                 445             


Arg Lys Lys Cys Thr Leu Thr Thr Gly 
    450                 455         


<210>  226
<211>  556
<212>  PRT
<213>  Homo sapiens

<400>  226

Met Gly Phe Trp Ile Leu Ala Ile Leu Thr Ile Leu Met Tyr Ser Thr 
1               5                   10                  15      


Ala Ala Lys Phe Ser Lys Gln Ser Trp Gly Leu Glu Asn Glu Ala Leu 
            20                  25                  30          


Ile Val Arg Cys Pro Arg Gln Gly Lys Pro Ser Tyr Thr Val Asp Trp 
        35                  40                  45              


Tyr Tyr Ser Gln Thr Asn Lys Ser Ile Pro Thr Gln Glu Arg Asn Arg 
    50                  55                  60                  


Val Phe Ala Ser Gly Gln Leu Leu Lys Phe Leu Pro Ala Ala Val Ala 
65                  70                  75                  80  


Asp Ser Gly Ile Tyr Thr Cys Ile Val Arg Ser Pro Thr Phe Asn Arg 
                85                  90                  95      


Thr Gly Tyr Ala Asn Val Thr Ile Tyr Lys Lys Gln Ser Asp Cys Asn 
            100                 105                 110         


Val Pro Asp Tyr Leu Met Tyr Ser Thr Val Ser Gly Ser Glu Lys Asn 
        115                 120                 125             


Ser Lys Ile Tyr Cys Pro Thr Ile Asp Leu Tyr Asn Trp Thr Ala Pro 
    130                 135                 140                 


Leu Glu Trp Phe Lys Asn Cys Gln Ala Leu Gln Gly Ser Arg Tyr Arg 
145                 150                 155                 160 


Ala His Lys Ser Phe Leu Val Ile Asp Asn Val Met Thr Glu Asp Ala 
                165                 170                 175     


Gly Asp Tyr Thr Cys Lys Phe Ile His Asn Glu Asn Gly Ala Asn Tyr 
            180                 185                 190         


Ser Val Thr Ala Thr Arg Ser Phe Thr Val Lys Asp Glu Gln Gly Phe 
        195                 200                 205             


Ser Leu Phe Pro Val Ile Gly Ala Pro Ala Gln Asn Glu Ile Lys Glu 
    210                 215                 220                 


Val Glu Ile Gly Lys Asn Ala Asn Leu Thr Cys Ser Ala Cys Phe Gly 
225                 230                 235                 240 


Lys Gly Thr Gln Phe Leu Ala Ala Val Leu Trp Gln Leu Asn Gly Thr 
                245                 250                 255     


Lys Ile Thr Asp Phe Gly Glu Pro Arg Ile Gln Gln Glu Glu Gly Gln 
            260                 265                 270         


Asn Gln Ser Phe Ser Asn Gly Leu Ala Cys Leu Asp Met Val Leu Arg 
        275                 280                 285             


Ile Ala Asp Val Lys Glu Glu Asp Leu Leu Leu Gln Tyr Asp Cys Leu 
    290                 295                 300                 


Ala Leu Asn Leu His Gly Leu Arg Arg His Thr Val Arg Leu Ser Arg 
305                 310                 315                 320 


Lys Asn Pro Ile Asp His His Ser Ile Tyr Cys Ile Ile Ala Val Cys 
                325                 330                 335     


Ser Val Phe Leu Met Leu Ile Asn Val Leu Val Ile Ile Leu Lys Met 
            340                 345                 350         


Phe Trp Ile Glu Ala Thr Leu Leu Trp Arg Asp Ile Ala Lys Pro Tyr 
        355                 360                 365             


Lys Thr Arg Asn Asp Gly Lys Leu Tyr Asp Ala Tyr Val Val Tyr Pro 
    370                 375                 380                 


Arg Asn Tyr Lys Ser Ser Thr Asp Gly Ala Ser Arg Val Glu His Phe 
385                 390                 395                 400 


Val His Gln Ile Leu Pro Asp Val Leu Glu Asn Lys Cys Gly Tyr Thr 
                405                 410                 415     


Leu Cys Ile Tyr Gly Arg Asp Met Leu Pro Gly Glu Asp Val Val Thr 
            420                 425                 430         


Ala Val Glu Thr Asn Ile Arg Lys Ser Arg Arg His Ile Phe Ile Leu 
        435                 440                 445             


Thr Pro Gln Ile Thr His Asn Lys Glu Phe Ala Tyr Glu Gln Glu Val 
    450                 455                 460                 


Ala Leu His Cys Ala Leu Ile Gln Asn Asp Ala Lys Val Ile Leu Ile 
465                 470                 475                 480 


Glu Met Glu Ala Leu Ser Glu Leu Asp Met Leu Gln Ala Glu Ala Leu 
                485                 490                 495     


Gln Asp Ser Leu Gln His Leu Met Lys Val Gln Gly Thr Ile Lys Trp 
            500                 505                 510         


Arg Glu Asp His Ile Ala Asn Lys Arg Ser Leu Asn Ser Lys Phe Trp 
        515                 520                 525             


Lys His Val Arg Tyr Gln Met Pro Val Pro Ser Lys Ile Pro Arg Lys 
    530                 535                 540                 


Ala Ser Ser Leu Thr Pro Leu Ala Ala Gln Lys Gln 
545                 550                 555     


<210>  227
<211>  328
<212>  PRT
<213>  Homo sapiens

<400>  227

Met Gly Phe Trp Ile Leu Ala Ile Leu Thr Ile Leu Met Tyr Ser Thr 
1               5                   10                  15      


Ala Ala Lys Phe Ser Lys Gln Ser Trp Gly Leu Glu Asn Glu Ala Leu 
            20                  25                  30          


Ile Val Arg Cys Pro Arg Gln Gly Lys Pro Ser Tyr Thr Val Asp Trp 
        35                  40                  45              


Tyr Tyr Ser Gln Thr Asn Lys Ser Ile Pro Thr Gln Glu Arg Asn Arg 
    50                  55                  60                  


Val Phe Ala Ser Gly Gln Leu Leu Lys Phe Leu Pro Ala Ala Val Ala 
65                  70                  75                  80  


Asp Ser Gly Ile Tyr Thr Cys Ile Val Arg Ser Pro Thr Phe Asn Arg 
                85                  90                  95      


Thr Gly Tyr Ala Asn Val Thr Ile Tyr Lys Lys Gln Ser Asp Cys Asn 
            100                 105                 110         


Val Pro Asp Tyr Leu Met Tyr Ser Thr Val Ser Gly Ser Glu Lys Asn 
        115                 120                 125             


Ser Lys Ile Tyr Cys Pro Thr Ile Asp Leu Tyr Asn Trp Thr Ala Pro 
    130                 135                 140                 


Leu Glu Trp Phe Lys Asn Cys Gln Ala Leu Gln Gly Ser Arg Tyr Arg 
145                 150                 155                 160 


Ala His Lys Ser Phe Leu Val Ile Asp Asn Val Met Thr Glu Asp Ala 
                165                 170                 175     


Gly Asp Tyr Thr Cys Lys Phe Ile His Asn Glu Asn Gly Ala Asn Tyr 
            180                 185                 190         


Ser Val Thr Ala Thr Arg Ser Phe Thr Val Lys Asp Glu Gln Gly Phe 
        195                 200                 205             


Ser Leu Phe Pro Val Ile Gly Ala Pro Ala Gln Asn Glu Ile Lys Glu 
    210                 215                 220                 


Val Glu Ile Gly Lys Asn Ala Asn Leu Thr Cys Ser Ala Cys Phe Gly 
225                 230                 235                 240 


Lys Gly Thr Gln Phe Leu Ala Ala Val Leu Trp Gln Leu Asn Gly Thr 
                245                 250                 255     


Lys Ile Thr Asp Phe Gly Glu Pro Arg Ile Gln Gln Glu Glu Gly Gln 
            260                 265                 270         


Asn Gln Ser Phe Ser Asn Gly Leu Ala Cys Leu Asp Met Val Leu Arg 
        275                 280                 285             


Ile Ala Asp Val Lys Glu Glu Asp Leu Leu Leu Gln Tyr Asp Cys Leu 
    290                 295                 300                 


Ala Leu Asn Leu His Gly Leu Arg Arg His Thr Val Arg Leu Ser Arg 
305                 310                 315                 320 


Lys Asn Pro Ser Lys Glu Cys Phe 
                325             


<210>  228
<211>  211
<212>  PRT
<213>  Homo sapiens

<400>  228

Met Tyr Ser Thr Val Ser Gly Ser Glu Lys Asn Ser Lys Ile Tyr Cys 
1               5                   10                  15      


Pro Thr Ile Asp Leu Tyr Asn Trp Thr Ala Pro Leu Glu Trp Phe Lys 
            20                  25                  30          


Asn Cys Gln Ala Leu Gln Gly Ser Arg Tyr Arg Ala His Lys Ser Phe 
        35                  40                  45              


Leu Val Ile Asp Asn Val Met Thr Glu Asp Ala Gly Asp Tyr Thr Cys 
    50                  55                  60                  


Lys Phe Ile His Asn Glu Asn Gly Ala Asn Tyr Ser Val Thr Ala Thr 
65                  70                  75                  80  


Arg Ser Phe Thr Val Lys Asp Glu Gln Gly Phe Ser Leu Phe Pro Val 
                85                  90                  95      


Ile Gly Ala Pro Ala Gln Asn Glu Ile Lys Glu Val Glu Ile Gly Lys 
            100                 105                 110         


Asn Ala Asn Leu Thr Cys Ser Ala Cys Phe Gly Lys Gly Thr Gln Phe 
        115                 120                 125             


Leu Ala Ala Val Leu Trp Gln Leu Asn Gly Thr Lys Ile Thr Asp Phe 
    130                 135                 140                 


Gly Glu Pro Arg Ile Gln Gln Glu Glu Gly Gln Asn Gln Ser Phe Ser 
145                 150                 155                 160 


Asn Gly Leu Ala Cys Leu Asp Met Val Leu Arg Ile Ala Asp Val Lys 
                165                 170                 175     


Glu Glu Asp Leu Leu Leu Gln Tyr Asp Cys Leu Ala Leu Asn Leu His 
            180                 185                 190         


Gly Leu Arg Arg His Thr Val Arg Leu Ser Arg Lys Asn Pro Ser Lys 
        195                 200                 205             


Glu Cys Phe 
    210     


<210>  229
<211>  314
<212>  PRT
<213>  Homo sapiens

<400>  229

Met Gly Phe Trp Ile Leu Ala Ile Leu Thr Ile Leu Met Tyr Ser Thr 
1               5                   10                  15      


Ala Ala Lys Phe Ser Lys Gln Ser Trp Gly Leu Glu Asn Glu Ala Leu 
            20                  25                  30          


Ile Val Arg Cys Pro Arg Gln Gly Lys Pro Ser Tyr Thr Val Asp Trp 
        35                  40                  45              


Tyr Tyr Ser Gln Thr Asn Lys Ser Ile Pro Thr Gln Glu Arg Asn Arg 
    50                  55                  60                  


Val Phe Ala Ser Gly Gln Leu Leu Lys Phe Leu Pro Ala Ala Val Ala 
65                  70                  75                  80  


Asp Ser Gly Ile Tyr Thr Cys Ile Val Arg Ser Pro Thr Phe Asn Arg 
                85                  90                  95      


Thr Gly Tyr Ala Asn Val Thr Ile Tyr Lys Lys Gln Ser Asp Cys Asn 
            100                 105                 110         


Val Pro Asp Tyr Leu Met Tyr Ser Thr Val Ser Gly Ser Glu Lys Asn 
        115                 120                 125             


Ser Lys Ile Tyr Cys Pro Thr Ile Asp Leu Tyr Asn Trp Thr Ala Pro 
    130                 135                 140                 


Leu Glu Trp Phe Lys Asn Cys Gln Ala Leu Gln Gly Ser Arg Tyr Arg 
145                 150                 155                 160 


Ala His Lys Ser Phe Leu Val Ile Asp Asn Val Met Thr Glu Asp Ala 
                165                 170                 175     


Gly Asp Tyr Thr Cys Lys Phe Ile His Asn Glu Asn Gly Ala Asn Tyr 
            180                 185                 190         


Ser Val Thr Ala Thr Arg Ser Phe Thr Val Lys Asp Glu Gln Gly Phe 
        195                 200                 205             


Ser Leu Phe Pro Val Ile Gly Ala Pro Ala Gln Asn Glu Ile Lys Glu 
    210                 215                 220                 


Val Glu Ile Gly Thr Gln Phe Leu Ala Ala Val Leu Trp Gln Leu Asn 
225                 230                 235                 240 


Gly Thr Lys Ile Thr Asp Phe Gly Glu Pro Arg Ile Gln Gln Glu Glu 
                245                 250                 255     


Gly Gln Asn Gln Ser Phe Ser Asn Gly Leu Ala Cys Leu Asp Met Val 
            260                 265                 270         


Leu Arg Ile Ala Asp Val Lys Glu Glu Asp Leu Leu Leu Gln Tyr Asp 
        275                 280                 285             


Cys Leu Ala Leu Asn Leu His Gly Leu Arg Arg His Thr Val Arg Leu 
    290                 295                 300                 


Ser Arg Lys Asn Pro Ser Lys Glu Cys Phe 
305                 310                 


<210>  230
<211>  259
<212>  PRT
<213>  Homo sapiens

<400>  230

Met Gly Phe Trp Ile Leu Ala Ile Leu Thr Ile Leu Met Tyr Ser Thr 
1               5                   10                  15      


Ala Ala Lys Phe Ser Lys Gln Ser Trp Gly Leu Glu Asn Glu Ala Leu 
            20                  25                  30          


Ile Val Arg Cys Pro Arg Gln Gly Lys Pro Ser Tyr Thr Val Asp Trp 
        35                  40                  45              


Tyr Tyr Ser Gln Thr Asn Lys Ser Ile Pro Thr Gln Glu Arg Asn Arg 
    50                  55                  60                  


Val Phe Ala Ser Gly Gln Leu Leu Lys Phe Leu Pro Ala Ala Val Ala 
65                  70                  75                  80  


Asp Ser Gly Ile Tyr Thr Cys Ile Val Arg Ser Pro Thr Phe Asn Arg 
                85                  90                  95      


Thr Gly Tyr Ala Asn Val Thr Ile Tyr Lys Lys Gln Ser Asp Cys Asn 
            100                 105                 110         


Val Pro Asp Tyr Leu Met Tyr Ser Thr Val Ser Gly Ser Glu Lys Asn 
        115                 120                 125             


Ser Lys Ile Tyr Cys Pro Thr Ile Asp Leu Tyr Asn Trp Thr Ala Pro 
    130                 135                 140                 


Leu Glu Trp Phe Lys Asn Cys Gln Ala Leu Gln Gly Ser Arg Tyr Arg 
145                 150                 155                 160 


Ala His Lys Ser Phe Leu Val Ile Asp Asn Val Met Thr Glu Asp Ala 
                165                 170                 175     


Gly Asp Tyr Thr Cys Lys Phe Ile His Asn Glu Asn Gly Ala Asn Tyr 
            180                 185                 190         


Ser Val Thr Ala Thr Arg Ser Phe Thr Val Lys Val Trp Cys Gln Ser 
        195                 200                 205             


Phe Cys Lys Leu Lys Lys Ser Leu Ile Phe Ser Asn Thr His Trp Ile 
    210                 215                 220                 


Gln Ser Leu Met Arg Gly Phe Val Met Val Tyr Tyr Gly Val His Lys 
225                 230                 235                 240 


Cys Cys Arg Val Val Phe Asn Leu Cys Leu Gln Tyr Phe Gln His His 
                245                 250                 255     


Gln Trp Pro 
            


<210>  231
<211>  38
<212>  PRT
<213>  Homo sapiens

<400>  231

Met Gly Phe Trp Ile Leu Ala Ile Leu Thr Ile Leu Met Tyr Ser Thr 
1               5                   10                  15      


Ala Ala Lys Phe Ser Lys Gln Ser Trp Gly Leu Glu Asn Glu Ala Leu 
            20                  25                  30          


Ile Val Arg Cys Pro Arg 
        35              


<210>  232
<211>  425
<212>  PRT
<213>  Homo sapiens

<400>  232

Met Val Ser Lys Ala Leu Leu Arg Leu Val Ser Ala Val Asn Arg Arg 
1               5                   10                  15      


Arg Met Lys Leu Leu Leu Gly Ile Ala Leu Leu Ala Tyr Val Ala Ser 
            20                  25                  30          


Val Trp Gly Asn Phe Val Asn Met Ser Phe Leu Leu Asn Arg Ser Ile 
        35                  40                  45              


Gln Glu Asn Gly Glu Leu Lys Ile Glu Ser Lys Ile Glu Glu Met Val 
    50                  55                  60                  


Glu Pro Leu Arg Glu Lys Ile Arg Asp Leu Glu Lys Ser Phe Thr Gln 
65                  70                  75                  80  


Lys Tyr Pro Pro Val Lys Phe Leu Ser Glu Lys Asp Arg Lys Arg Ile 
                85                  90                  95      


Leu Ile Thr Gly Gly Ala Gly Phe Val Gly Ser His Leu Thr Asp Lys 
            100                 105                 110         


Leu Met Met Asp Gly His Glu Val Thr Val Val Asp Asn Phe Phe Thr 
        115                 120                 125             


Gly Arg Lys Arg Asn Val Glu His Trp Ile Gly His Glu Asn Phe Glu 
    130                 135                 140                 


Leu Ile Asn His Asp Val Val Glu Pro Leu Tyr Ile Glu Val Asp Gln 
145                 150                 155                 160 


Ile Tyr His Leu Ala Ser Pro Ala Ser Pro Pro Asn Tyr Met Tyr Asn 
                165                 170                 175     


Pro Ile Lys Thr Leu Lys Thr Asn Thr Ile Gly Thr Leu Asn Met Leu 
            180                 185                 190         


Gly Leu Ala Lys Arg Val Gly Ala Arg Leu Leu Leu Ala Ser Thr Ser 
        195                 200                 205             


Glu Val Tyr Gly Asp Pro Glu Val His Pro Gln Ser Glu Asp Tyr Trp 
    210                 215                 220                 


Gly His Val Asn Pro Ile Gly Pro Arg Ala Cys Tyr Asp Glu Gly Lys 
225                 230                 235                 240 


Arg Val Ala Glu Thr Met Cys Tyr Ala Tyr Met Lys Gln Glu Gly Val 
                245                 250                 255     


Glu Val Arg Val Ala Arg Ile Phe Asn Thr Phe Gly Pro Arg Met His 
            260                 265                 270         


Met Asn Asp Gly Arg Val Val Ser Asn Phe Ile Leu Gln Ala Leu Gln 
        275                 280                 285             


Gly Glu Pro Leu Thr Val Tyr Gly Ser Gly Ser Gln Thr Arg Ala Phe 
    290                 295                 300                 


Gln Tyr Val Ser Asp Leu Val Asn Gly Leu Val Ala Leu Met Asn Ser 
305                 310                 315                 320 


Asn Val Ser Ser Pro Val Asn Leu Gly Asn Pro Glu Glu His Thr Ile 
                325                 330                 335     


Leu Glu Phe Ala Gln Leu Ile Lys Asn Leu Val Gly Ser Gly Ser Glu 
            340                 345                 350         


Ile Gln Phe Leu Ser Glu Ala Gln Asp Asp Pro Gln Lys Arg Lys Pro 
        355                 360                 365             


Asp Ile Lys Lys Ala Lys Leu Met Leu Gly Trp Glu Pro Val Val Pro 
    370                 375                 380                 


Leu Glu Glu Gly Leu Asn Lys Ala Ile His Tyr Phe Arg Lys Glu Leu 
385                 390                 395                 400 


Glu Tyr Gln Ala Asn Asn Gln Tyr Ile Pro Lys Pro Lys Pro Ala Arg 
                405                 410                 415     


Ile Lys Lys Gly Arg Thr Arg His Ser 
            420                 425 


<210>  233
<211>  420
<212>  PRT
<213>  Homo sapiens

<400>  233

Met Val Ser Lys Ala Leu Leu Arg Leu Val Ser Ala Val Asn Arg Arg 
1               5                   10                  15      


Arg Met Lys Leu Leu Leu Gly Ile Ala Leu Leu Ala Tyr Val Ala Ser 
            20                  25                  30          


Val Trp Gly Asn Phe Val Asn Met Arg Ser Ile Gln Glu Asn Gly Glu 
        35                  40                  45              


Leu Lys Ile Glu Ser Lys Ile Glu Glu Met Val Glu Pro Leu Arg Glu 
    50                  55                  60                  


Lys Ile Arg Asp Leu Glu Lys Ser Phe Thr Gln Lys Tyr Pro Pro Val 
65                  70                  75                  80  


Lys Phe Leu Ser Glu Lys Asp Arg Lys Arg Ile Leu Ile Thr Gly Gly 
                85                  90                  95      


Ala Gly Phe Val Gly Ser His Leu Thr Asp Lys Leu Met Met Asp Gly 
            100                 105                 110         


His Glu Val Thr Val Val Asp Asn Phe Phe Thr Gly Arg Lys Arg Asn 
        115                 120                 125             


Val Glu His Trp Ile Gly His Glu Asn Phe Glu Leu Ile Asn His Asp 
    130                 135                 140                 


Val Val Glu Pro Leu Tyr Ile Glu Val Asp Gln Ile Tyr His Leu Ala 
145                 150                 155                 160 


Ser Pro Ala Ser Pro Pro Asn Tyr Met Tyr Asn Pro Ile Lys Thr Leu 
                165                 170                 175     


Lys Thr Asn Thr Ile Gly Thr Leu Asn Met Leu Gly Leu Ala Lys Arg 
            180                 185                 190         


Val Gly Ala Arg Leu Leu Leu Ala Ser Thr Ser Glu Val Tyr Gly Asp 
        195                 200                 205             


Pro Glu Val His Pro Gln Ser Glu Asp Tyr Trp Gly His Val Asn Pro 
    210                 215                 220                 


Ile Gly Pro Arg Ala Cys Tyr Asp Glu Gly Lys Arg Val Ala Glu Thr 
225                 230                 235                 240 


Met Cys Tyr Ala Tyr Met Lys Gln Glu Gly Val Glu Val Arg Val Ala 
                245                 250                 255     


Arg Ile Phe Asn Thr Phe Gly Pro Arg Met His Met Asn Asp Gly Arg 
            260                 265                 270         


Val Val Ser Asn Phe Ile Leu Gln Ala Leu Gln Gly Glu Pro Leu Thr 
        275                 280                 285             


Val Tyr Gly Ser Gly Ser Gln Thr Arg Ala Phe Gln Tyr Val Ser Asp 
    290                 295                 300                 


Leu Val Asn Gly Leu Val Ala Leu Met Asn Ser Asn Val Ser Ser Pro 
305                 310                 315                 320 


Val Asn Leu Gly Asn Pro Glu Glu His Thr Ile Leu Glu Phe Ala Gln 
                325                 330                 335     


Leu Ile Lys Asn Leu Val Gly Ser Gly Ser Glu Ile Gln Phe Leu Ser 
            340                 345                 350         


Glu Ala Gln Asp Asp Pro Gln Lys Arg Lys Pro Asp Ile Lys Lys Ala 
        355                 360                 365             


Lys Leu Met Leu Gly Trp Glu Pro Val Val Pro Leu Glu Glu Gly Leu 
    370                 375                 380                 


Asn Lys Ala Ile His Tyr Phe Arg Lys Glu Leu Glu Tyr Gln Ala Asn 
385                 390                 395                 400 


Asn Gln Tyr Ile Pro Lys Pro Lys Pro Ala Arg Ile Lys Lys Gly Arg 
                405                 410                 415     


Thr Arg His Ser 
            420 


<210>  234
<211>  171
<212>  PRT
<213>  Homo sapiens

<400>  234

Met Val Ser Lys Ala Leu Leu Arg Leu Val Ser Ala Val Asn Arg Arg 
1               5                   10                  15      


Arg Met Lys Leu Leu Leu Gly Ile Ala Leu Leu Ala Tyr Val Ala Trp 
            20                  25                  30          


Leu Ala Lys Arg Val Gly Ala Arg Leu Leu Leu Ala Ser Thr Ser Glu 
        35                  40                  45              


Val Tyr Gly Asp Pro Glu Val His Pro Gln Ser Glu Asp Tyr Trp Gly 
    50                  55                  60                  


His Val Asn Pro Ile Gly Pro Arg Ala Cys Tyr Asp Glu Gly Lys Arg 
65                  70                  75                  80  


Val Ala Glu Thr Met Cys Tyr Ala Tyr Met Lys Gln Glu Gly Val Glu 
                85                  90                  95      


Val Arg Val Ala Arg Ile Phe Asn Thr Phe Gly Pro Arg Met His Met 
            100                 105                 110         


Asn Asp Gly Arg Val Val Ser Asn Phe Ile Leu Gln Ala Leu Gln Gly 
        115                 120                 125             


Glu Pro Leu Thr Val Tyr Gly Ser Gly Ser Gln Thr Arg Ala Phe Gln 
    130                 135                 140                 


Tyr Val Ser Asp Leu Val Asn Gly Leu Val Ala Leu Met Asn Ser Asn 
145                 150                 155                 160 


Val Ser Ser Pro Val Asn Leu Val Ser Ala Pro 
                165                 170     


<210>  235
<211>  190
<212>  PRT
<213>  Homo sapiens

<400>  235

Met Val Glu Pro Leu Arg Glu Lys Ile Arg Asp Leu Glu Lys Ser Phe 
1               5                   10                  15      


Thr Gln Lys Tyr Pro Pro Val Lys Phe Leu Ser Glu Lys Asp Arg Lys 
            20                  25                  30          


Arg Ile Leu Ile Thr Gly Gly Ala Gly Phe Val Gly Ser His Leu Thr 
        35                  40                  45              


Asp Lys Leu Met Met Asp Gly His Glu Val Thr Val Val Asp Asn Phe 
    50                  55                  60                  


Phe Thr Gly Arg Lys Arg Asn Val Glu His Trp Ile Gly His Glu Asn 
65                  70                  75                  80  


Phe Glu Leu Ile Asn His Asp Val Val Glu Pro Leu Tyr Ile Glu Val 
                85                  90                  95      


Asp Gln Ile Tyr His Leu Ala Ser Pro Ala Ser Pro Pro Asn Tyr Met 
            100                 105                 110         


Tyr Asn Pro Ile Lys Thr Leu Lys Thr Asn Thr Ile Gly Thr Leu Asn 
        115                 120                 125             


Met Leu Gly Leu Ala Lys Arg Val Gly Ala Arg Leu Leu Leu Ala Ser 
    130                 135                 140                 


Thr Ser Glu Val Tyr Gly Asp Pro Glu Val His Pro Gln Ser Glu Asp 
145                 150                 155                 160 


Tyr Trp Gly His Val Asn Pro Ile Gly Pro Arg Ala Cys Tyr Asp Glu 
                165                 170                 175     


Gly Lys Arg Val Ala Glu Thr Met Cys Tyr Ala Tyr Met Lys 
            180                 185                 190 


<210>  236
<211>  210
<212>  PRT
<213>  Homo sapiens

<400>  236

Met Ala Val Lys Val Gln Thr Thr Lys Arg Gly Asp Pro His Glu Leu 
1               5                   10                  15      


Arg Asn Ile Phe Leu Gln Tyr Ala Ser Thr Glu Val Asp Gly Glu Arg 
            20                  25                  30          


Tyr Met Thr Pro Glu Asp Phe Val Gln Arg Tyr Leu Gly Leu Tyr Asn 
        35                  40                  45              


Asp Pro Asn Ser Asn Pro Lys Ile Val Gln Leu Leu Ala Gly Val Ala 
    50                  55                  60                  


Asp Gln Thr Lys Asp Gly Leu Ile Ser Tyr Gln Glu Phe Leu Ala Phe 
65                  70                  75                  80  


Glu Ser Val Leu Cys Ala Pro Asp Ser Met Phe Ile Val Ala Phe Gln 
                85                  90                  95      


Leu Phe Asp Lys Ser Gly Asn Gly Glu Val Thr Phe Gly Gly Val Leu 
            100                 105                 110         


Trp Pro His Arg Trp Tyr Ser Ser Ser Phe Gln Ala His Ser Trp Asn 
        115                 120                 125             


Arg His Gly Gly Ser Leu Gly Glu Glu Cys Gln Pro Arg Ser Glu Lys 
    130                 135                 140                 


Met Ser Lys Lys Phe Leu Asp Arg Leu Leu Phe Ile Ile Ile Ser Leu 
145                 150                 155                 160 


Leu Thr Gly Ile Val Asn Leu Ser Asp Cys Ile Leu Gly Ile Thr Gly 
                165                 170                 175     


Arg Ser Ile Leu Thr Thr Gln Asn Ser Arg Ser Phe Ser Arg Ser Cys 
            180                 185                 190         


Asn Trp Asn Met Gln Asp Lys Pro Leu His Ser Lys Thr Lys Ala Lys 
        195                 200                 205             


Val Ala 
    210 


<210>  237
<211>  870
<212>  PRT
<213>  Homo sapiens

<400>  237

Met Gly Val Lys Lys Lys Lys Glu Met Gln Val Ala Ala Leu Thr Ile 
1               5                   10                  15      


Cys His Gln Asp Leu Glu Thr Leu Lys Ser Phe Ala Asp Val Glu Gly 
            20                  25                  30          


Lys Asn Leu Ala Ser Leu Leu Leu His Cys Val Gln Leu Thr Asp Gly 
        35                  40                  45              


Val Ser Gln Ile His Tyr Ile Lys Gln Ile Val Pro Leu Leu Glu Lys 
    50                  55                  60                  


Ala Asp Lys Asn Gly Met Cys Asp Pro Thr Ile Gln Ser Cys Leu Asp 
65                  70                  75                  80  


Ile Leu Ala Gly Ile Tyr Leu Ser Leu Ser Leu Lys Asn Pro Leu Lys 
                85                  90                  95      


Lys Val Leu Ala Ser Ser Leu Asn Ser Leu Pro Asp Phe Phe Leu Pro 
            100                 105                 110         


Glu Ala Met His Arg Phe Thr Ser Arg Leu Gln Glu Glu Leu Asn Thr 
        115                 120                 125             


Thr Asp Leu Tyr Ser Tyr Arg Lys Val Thr Asp Asn Ile Ser Ser Cys 
    130                 135                 140                 


Met Glu Asn Phe Asn Leu Gly Arg Ala Ser Val Asn Asn Leu Leu Lys 
145                 150                 155                 160 


Asn Val Leu His Phe Leu Gln Lys Ser Leu Ile Glu Ile Leu Glu Glu 
                165                 170                 175     


Asn Arg Lys Cys Ala Gly Asn His Ile Ile Gln Thr Gln Leu Met Asn 
            180                 185                 190         


Asp Leu Leu Val Gly Ile Arg Val Ser Met Met Leu Val Gln Lys Val 
        195                 200                 205             


Gln Asp Phe Gln Gly Asn Leu Trp Lys Thr Ser Asp Ser Pro Ile Trp 
    210                 215                 220                 


Gln Asn Met Cys Gly Leu Leu Ser Ile Phe Thr Lys Val Leu Ser Asp 
225                 230                 235                 240 


Asp Asp Leu Leu Gln Thr Val Gln Ser Thr Ser Gly Leu Ala Ile Ile 
                245                 250                 255     


Leu Phe Ile Lys Thr Met Phe His Pro Ser Glu Lys Ile Pro His Leu 
            260                 265                 270         


Ile Ser Ser Val Leu Leu Arg Ser Val Asp Cys Thr Ser Val Pro Glu 
        275                 280                 285             


Trp Phe Met Ser Ser Cys Arg Ser Leu Cys Cys Gly Asp Ile Ser Gln 
    290                 295                 300                 


Ser Ala Val Leu Phe Leu Cys Gln Gly Thr Leu Ala Met Leu Asp Trp 
305                 310                 315                 320 


Gln Asn Gly Ser Met Gly Arg Ser Gly Glu Ala Leu Leu Leu Asp Thr 
                325                 330                 335     


Ala His Val Leu Phe Thr Leu Ser Ser Gln Ile Lys Glu Pro Thr Leu 
            340                 345                 350         


Glu Met Phe Leu Ser Arg Ile Leu Ala Ser Trp Thr Asn Ser Ala Ile 
        355                 360                 365             


Gln Val Leu Glu Ser Ser Ser Pro Ser Leu Thr Asp Ser Leu Asn Gly 
    370                 375                 380                 


Asn Ser Ser Ile Val Gly Arg Leu Leu Glu Tyr Val Tyr Thr His Trp 
385                 390                 395                 400 


Glu His Pro Leu Asp Ala Leu Arg His Gln Thr Lys Ile Met Phe Lys 
                405                 410                 415     


Asn Leu Leu Gln Met His Arg Leu Thr Val Glu Gly Ala Asp Phe Val 
            420                 425                 430         


Pro Asp Pro Phe Phe Val Glu Leu Thr Glu Ser Leu Leu Arg Leu Glu 
        435                 440                 445             


Trp His Ile Lys Gly Lys Tyr Thr Cys Leu Gly Cys Leu Val Glu Cys 
    450                 455                 460                 


Ile Gly Val Glu His Ile Leu Ala Ile Asp Lys Thr Ile Pro Ser Gln 
465                 470                 475                 480 


Ile Leu Glu Val Met Gly Asp Gln Ser Leu Val Pro Tyr Ala Ser Asp 
                485                 490                 495     


Leu Leu Glu Thr Met Phe Arg Asn His Lys Ser His Leu Lys Ser Gln 
            500                 505                 510         


Thr Ala Glu Ser Ser Trp Ile Asp Gln Trp His Glu Thr Trp Val Ser 
        515                 520                 525             


Pro Leu Leu Phe Ile Leu Cys Glu Gly Asn Leu Asp Gln Lys Ser Tyr 
    530                 535                 540                 


Val Ile Asp Tyr Tyr Leu Pro Lys Leu Leu Ser Tyr Ser Pro Glu Ser 
545                 550                 555                 560 


Leu Gln Tyr Met Val Lys Ile Leu Gln Thr Ser Ile Asp Ala Lys Thr 
                565                 570                 575     


Gly Gln Glu Gln Ser Phe Pro Ser Leu Gly Ser Cys Asn Ser Arg Gly 
            580                 585                 590         


Ala Leu Gly Ala Leu Met Ala Cys Leu Arg Ile Ala Arg Ala His Gly 
        595                 600                 605             


His Leu Gln Ser Ala Thr Asp Thr Trp Glu Asn Leu Val Ser Asp Ala 
    610                 615                 620                 


Arg Ile Lys Gln Gly Leu Ile His Gln His Cys Gln Val Arg Ile Asp 
625                 630                 635                 640 


Thr Leu Gly Leu Leu Cys Glu Ser Asn Arg Ser Thr Glu Ile Val Ser 
                645                 650                 655     


Met Glu Glu Met Gln Trp Ile Gln Phe Phe Ile Thr Tyr Asn Leu Asn 
            660                 665                 670         


Ser Gln Ser Pro Gly Val Arg Gln Gln Ile Cys Ser Leu Leu Lys Lys 
        675                 680                 685             


Leu Phe Cys Arg Ile Gln Glu Ser Ser Gln Val Leu Tyr Lys Leu Glu 
    690                 695                 700                 


Gln Ser Lys Ser Lys Arg Glu Pro Glu Asn Glu Leu Thr Lys Gln His 
705                 710                 715                 720 


Pro Ser Val Ser Leu Gln Gln Tyr Lys Asn Phe Met Ser Ser Ile Cys 
                725                 730                 735     


Asn Ser Leu Phe Glu Ala Leu Phe Pro Gly Ser Ser Tyr Ser Thr Arg 
            740                 745                 750         


Phe Ser Ala Leu Thr Ile Leu Gly Ser Ile Ala Glu Val Phe His Val 
        755                 760                 765             


Pro Glu Gly Lys Cys Leu Ile Met Leu Gly Glu Val Ile Phe Val Phe 
    770                 775                 780                 


Phe Gln Asn Ile Leu Ile Leu His Phe Ala Leu Phe Glu Val Ser Val 
785                 790                 795                 800 


Leu Leu Pro Phe Phe Glu Val Ser Phe Leu Pro Tyr Asn Ser Cys Leu 
                805                 810                 815     


Tyr Ile Met Lys Phe Ala Ser Lys Gly Gln Lys Arg Lys Lys Leu Ser 
            820                 825                 830         


Pro Phe Ser Leu Ile Ile Ile Cys Gln Pro Gln Ser Ile Ile Phe Met 
        835                 840                 845             


Asp Tyr Ala Tyr Tyr Gly Lys Ser Ser Ser Tyr Tyr Leu Thr Asn Leu 
    850                 855                 860                 


Phe Val Ala Val Leu Arg 
865                 870 


<210>  238
<211>  906
<212>  PRT
<213>  Homo sapiens

<400>  238

Met Ile Cys Gln Lys Phe Cys Val Val Leu Leu His Trp Glu Phe Ile 
1               5                   10                  15      


Tyr Val Ile Thr Ala Phe Asn Leu Ser Tyr Pro Ile Thr Pro Trp Arg 
            20                  25                  30          


Phe Lys Leu Ser Cys Met Pro Pro Asn Ser Thr Tyr Asp Tyr Phe Leu 
        35                  40                  45              


Leu Pro Ala Gly Leu Ser Lys Asn Thr Ser Asn Ser Asn Gly His Tyr 
    50                  55                  60                  


Glu Thr Ala Val Glu Pro Lys Phe Asn Ser Ser Gly Thr His Phe Ser 
65                  70                  75                  80  


Asn Leu Ser Lys Thr Thr Phe His Cys Cys Phe Arg Ser Glu Gln Asp 
                85                  90                  95      


Arg Asn Cys Ser Leu Cys Ala Asp Asn Ile Glu Gly Lys Thr Phe Val 
            100                 105                 110         


Ser Thr Val Asn Ser Leu Val Phe Gln Gln Ile Asp Ala Asn Trp Asn 
        115                 120                 125             


Ile Gln Cys Trp Leu Lys Gly Asp Leu Lys Leu Phe Ile Cys Tyr Val 
    130                 135                 140                 


Glu Ser Leu Phe Lys Asn Leu Phe Arg Asn Tyr Asn Tyr Lys Val His 
145                 150                 155                 160 


Leu Leu Tyr Val Leu Pro Glu Val Leu Glu Asp Ser Pro Leu Val Pro 
                165                 170                 175     


Gln Lys Gly Ser Phe Gln Met Val His Cys Asn Cys Ser Val His Glu 
            180                 185                 190         


Cys Cys Glu Cys Leu Val Pro Val Pro Thr Ala Lys Leu Asn Asp Thr 
        195                 200                 205             


Leu Leu Met Cys Leu Lys Ile Thr Ser Gly Gly Val Ile Phe Gln Ser 
    210                 215                 220                 


Pro Leu Met Ser Val Gln Pro Ile Asn Met Val Lys Pro Asp Pro Pro 
225                 230                 235                 240 


Leu Gly Leu His Met Glu Ile Thr Asp Asp Gly Asn Leu Lys Ile Ser 
                245                 250                 255     


Trp Ser Ser Pro Pro Leu Val Pro Phe Pro Leu Gln Tyr Gln Val Lys 
            260                 265                 270         


Tyr Ser Glu Asn Ser Thr Thr Val Ile Arg Glu Ala Asp Lys Ile Val 
        275                 280                 285             


Ser Ala Thr Ser Leu Leu Val Asp Ser Ile Leu Pro Gly Ser Ser Tyr 
    290                 295                 300                 


Glu Val Gln Val Arg Gly Lys Arg Leu Asp Gly Pro Gly Ile Trp Ser 
305                 310                 315                 320 


Asp Trp Ser Thr Pro Arg Val Phe Thr Thr Gln Asp Val Ile Tyr Phe 
                325                 330                 335     


Pro Pro Lys Ile Leu Thr Ser Val Gly Ser Asn Val Ser Phe His Cys 
            340                 345                 350         


Ile Tyr Lys Lys Glu Asn Lys Ile Val Pro Ser Lys Glu Ile Val Trp 
        355                 360                 365             


Trp Met Asn Leu Ala Glu Lys Ile Pro Gln Ser Gln Tyr Asp Val Val 
    370                 375                 380                 


Ser Asp His Val Ser Lys Val Thr Phe Phe Asn Leu Asn Glu Thr Lys 
385                 390                 395                 400 


Pro Arg Gly Lys Phe Thr Tyr Asp Ala Val Tyr Cys Cys Asn Glu His 
                405                 410                 415     


Glu Cys His His Arg Tyr Ala Glu Leu Tyr Val Ile Asp Val Asn Ile 
            420                 425                 430         


Asn Ile Ser Cys Glu Thr Asp Gly Tyr Leu Thr Lys Met Thr Cys Arg 
        435                 440                 445             


Trp Ser Thr Ser Thr Ile Gln Ser Leu Ala Glu Ser Thr Leu Gln Leu 
    450                 455                 460                 


Arg Tyr His Arg Ser Ser Leu Tyr Cys Ser Asp Ile Pro Ser Ile His 
465                 470                 475                 480 


Pro Ile Ser Glu Pro Lys Asp Cys Tyr Leu Gln Ser Asp Gly Phe Tyr 
                485                 490                 495     


Glu Cys Ile Phe Gln Pro Ile Phe Leu Leu Ser Gly Tyr Thr Met Trp 
            500                 505                 510         


Ile Arg Ile Asn His Ser Leu Gly Ser Leu Asp Ser Pro Pro Thr Cys 
        515                 520                 525             


Val Leu Pro Asp Ser Val Val Lys Pro Leu Pro Pro Ser Ser Val Lys 
    530                 535                 540                 


Ala Glu Ile Thr Ile Asn Ile Gly Leu Leu Lys Ile Ser Trp Glu Lys 
545                 550                 555                 560 


Pro Val Phe Pro Glu Asn Asn Leu Gln Phe Gln Ile Arg Tyr Gly Leu 
                565                 570                 575     


Ser Gly Lys Glu Val Gln Trp Lys Met Tyr Glu Val Tyr Asp Ala Lys 
            580                 585                 590         


Ser Lys Ser Val Ser Leu Pro Val Pro Asp Leu Cys Ala Val Tyr Ala 
        595                 600                 605             


Val Gln Val Arg Cys Lys Arg Leu Asp Gly Leu Gly Tyr Trp Ser Asn 
    610                 615                 620                 


Trp Ser Asn Pro Ala Tyr Thr Val Val Met Asp Ile Lys Val Pro Met 
625                 630                 635                 640 


Arg Gly Pro Glu Phe Trp Arg Ile Ile Asn Gly Asp Thr Met Lys Lys 
                645                 650                 655     


Glu Lys Asn Val Thr Leu Leu Trp Lys Pro Leu Met Lys Asn Asp Ser 
            660                 665                 670         


Leu Cys Ser Val Gln Arg Tyr Val Ile Asn His His Thr Ser Cys Asn 
        675                 680                 685             


Gly Thr Trp Ser Glu Asp Val Gly Asn His Thr Lys Phe Thr Phe Leu 
    690                 695                 700                 


Trp Thr Glu Gln Ala His Thr Val Thr Val Leu Ala Ile Asn Ser Ile 
705                 710                 715                 720 


Gly Ala Ser Val Ala Asn Phe Asn Leu Thr Phe Ser Trp Pro Met Ser 
                725                 730                 735     


Lys Val Asn Ile Val Gln Ser Leu Ser Ala Tyr Pro Leu Asn Ser Ser 
            740                 745                 750         


Cys Val Ile Val Ser Trp Ile Leu Ser Pro Ser Asp Tyr Lys Leu Met 
        755                 760                 765             


Tyr Phe Ile Ile Glu Trp Lys Asn Leu Asn Glu Asp Gly Glu Ile Lys 
    770                 775                 780                 


Trp Leu Arg Ile Ser Ser Ser Val Lys Lys Tyr Tyr Ile His Asp His 
785                 790                 795                 800 


Phe Ile Pro Ile Glu Lys Tyr Gln Phe Ser Leu Tyr Pro Ile Phe Met 
                805                 810                 815     


Glu Gly Val Gly Lys Pro Lys Ile Ile Asn Ser Phe Thr Gln Asp Asp 
            820                 825                 830         


Ile Glu Lys His Gln Ser Asp Ala Gly Leu Tyr Val Ile Val Pro Val 
        835                 840                 845             


Ile Ile Ser Ser Ser Ile Leu Leu Leu Gly Thr Leu Leu Ile Ser His 
    850                 855                 860                 


Gln Arg Met Lys Lys Leu Phe Trp Glu Asp Val Pro Asn Pro Lys Asn 
865                 870                 875                 880 


Cys Ser Trp Ala Gln Gly Leu Asn Phe Gln Lys Lys Met Pro Gly Thr 
                885                 890                 895     


Lys Glu Leu Leu Gly Gly Gly Trp Leu Thr 
            900                 905     


<210>  239
<211>  1165
<212>  PRT
<213>  Homo sapiens

<400>  239

Met Ile Cys Gln Lys Phe Cys Val Val Leu Leu His Trp Glu Phe Ile 
1               5                   10                  15      


Tyr Val Ile Thr Ala Phe Asn Leu Ser Tyr Pro Ile Thr Pro Trp Arg 
            20                  25                  30          


Phe Lys Leu Ser Cys Met Pro Pro Asn Ser Thr Tyr Asp Tyr Phe Leu 
        35                  40                  45              


Leu Pro Ala Gly Leu Ser Lys Asn Thr Ser Asn Ser Asn Gly His Tyr 
    50                  55                  60                  


Glu Thr Ala Val Glu Pro Lys Phe Asn Ser Ser Gly Thr His Phe Ser 
65                  70                  75                  80  


Asn Leu Ser Lys Thr Thr Phe His Cys Cys Phe Arg Ser Glu Gln Asp 
                85                  90                  95      


Arg Asn Cys Ser Leu Cys Ala Asp Asn Ile Glu Gly Lys Thr Phe Val 
            100                 105                 110         


Ser Thr Val Asn Ser Leu Val Phe Gln Gln Ile Asp Ala Asn Trp Asn 
        115                 120                 125             


Ile Gln Cys Trp Leu Lys Gly Asp Leu Lys Leu Phe Ile Cys Tyr Val 
    130                 135                 140                 


Glu Ser Leu Phe Lys Asn Leu Phe Arg Asn Tyr Asn Tyr Lys Val His 
145                 150                 155                 160 


Leu Leu Tyr Val Leu Pro Glu Val Leu Glu Asp Ser Pro Leu Val Pro 
                165                 170                 175     


Gln Lys Gly Ser Phe Gln Met Val His Cys Asn Cys Ser Val His Glu 
            180                 185                 190         


Cys Cys Glu Cys Leu Val Pro Val Pro Thr Ala Lys Leu Asn Asp Thr 
        195                 200                 205             


Leu Leu Met Cys Leu Lys Ile Thr Ser Gly Gly Val Ile Phe Gln Ser 
    210                 215                 220                 


Pro Leu Met Ser Val Gln Pro Ile Asn Met Val Lys Pro Asp Pro Pro 
225                 230                 235                 240 


Leu Gly Leu His Met Glu Ile Thr Asp Asp Gly Asn Leu Lys Ile Ser 
                245                 250                 255     


Trp Ser Ser Pro Pro Leu Val Pro Phe Pro Leu Gln Tyr Gln Val Lys 
            260                 265                 270         


Tyr Ser Glu Asn Ser Thr Thr Val Ile Arg Glu Ala Asp Lys Ile Val 
        275                 280                 285             


Ser Ala Thr Ser Leu Leu Val Asp Ser Ile Leu Pro Gly Ser Ser Tyr 
    290                 295                 300                 


Glu Val Gln Val Arg Gly Lys Arg Leu Asp Gly Pro Gly Ile Trp Ser 
305                 310                 315                 320 


Asp Trp Ser Thr Pro Arg Val Phe Thr Thr Gln Asp Val Ile Tyr Phe 
                325                 330                 335     


Pro Pro Lys Ile Leu Thr Ser Val Gly Ser Asn Val Ser Phe His Cys 
            340                 345                 350         


Ile Tyr Lys Lys Glu Asn Lys Ile Val Pro Ser Lys Glu Ile Val Trp 
        355                 360                 365             


Trp Met Asn Leu Ala Glu Lys Ile Pro Gln Ser Gln Tyr Asp Val Val 
    370                 375                 380                 


Ser Asp His Val Ser Lys Val Thr Phe Phe Asn Leu Asn Glu Thr Lys 
385                 390                 395                 400 


Pro Arg Gly Lys Phe Thr Tyr Asp Ala Val Tyr Cys Cys Asn Glu His 
                405                 410                 415     


Glu Cys His His Arg Tyr Ala Glu Leu Tyr Val Ile Asp Val Asn Ile 
            420                 425                 430         


Asn Ile Ser Cys Glu Thr Asp Gly Tyr Leu Thr Lys Met Thr Cys Arg 
        435                 440                 445             


Trp Ser Thr Ser Thr Ile Gln Ser Leu Ala Glu Ser Thr Leu Gln Leu 
    450                 455                 460                 


Arg Tyr His Arg Ser Ser Leu Tyr Cys Ser Asp Ile Pro Ser Ile His 
465                 470                 475                 480 


Pro Ile Ser Glu Pro Lys Asp Cys Tyr Leu Gln Ser Asp Gly Phe Tyr 
                485                 490                 495     


Glu Cys Ile Phe Gln Pro Ile Phe Leu Leu Ser Gly Tyr Thr Met Trp 
            500                 505                 510         


Ile Arg Ile Asn His Ser Leu Gly Ser Leu Asp Ser Pro Pro Thr Cys 
        515                 520                 525             


Val Leu Pro Asp Ser Val Val Lys Pro Leu Pro Pro Ser Ser Val Lys 
    530                 535                 540                 


Ala Glu Ile Thr Ile Asn Ile Gly Leu Leu Lys Ile Ser Trp Glu Lys 
545                 550                 555                 560 


Pro Val Phe Pro Glu Asn Asn Leu Gln Phe Gln Ile Arg Tyr Gly Leu 
                565                 570                 575     


Ser Gly Lys Glu Val Gln Trp Lys Met Tyr Glu Val Tyr Asp Ala Lys 
            580                 585                 590         


Ser Lys Ser Val Ser Leu Pro Val Pro Asp Leu Cys Ala Val Tyr Ala 
        595                 600                 605             


Val Gln Val Arg Cys Lys Arg Leu Asp Gly Leu Gly Tyr Trp Ser Asn 
    610                 615                 620                 


Trp Ser Asn Pro Ala Tyr Thr Val Val Met Asp Ile Lys Val Pro Met 
625                 630                 635                 640 


Arg Gly Pro Glu Phe Trp Arg Ile Ile Asn Gly Asp Thr Met Lys Lys 
                645                 650                 655     


Glu Lys Asn Val Thr Leu Leu Trp Lys Pro Leu Met Lys Asn Asp Ser 
            660                 665                 670         


Leu Cys Ser Val Gln Arg Tyr Val Ile Asn His His Thr Ser Cys Asn 
        675                 680                 685             


Gly Thr Trp Ser Glu Asp Val Gly Asn His Thr Lys Phe Thr Phe Leu 
    690                 695                 700                 


Trp Thr Glu Gln Ala His Thr Val Thr Val Leu Ala Ile Asn Ser Ile 
705                 710                 715                 720 


Gly Ala Ser Val Ala Asn Phe Asn Leu Thr Phe Ser Trp Pro Met Ser 
                725                 730                 735     


Lys Val Asn Ile Val Gln Ser Leu Ser Ala Tyr Pro Leu Asn Ser Ser 
            740                 745                 750         


Cys Val Ile Val Ser Trp Ile Leu Ser Pro Ser Asp Tyr Lys Leu Met 
        755                 760                 765             


Tyr Phe Ile Ile Glu Trp Lys Asn Leu Asn Glu Asp Gly Glu Ile Lys 
    770                 775                 780                 


Trp Leu Arg Ile Ser Ser Ser Val Lys Lys Tyr Tyr Ile His Asp His 
785                 790                 795                 800 


Phe Ile Pro Ile Glu Lys Tyr Gln Phe Ser Leu Tyr Pro Ile Phe Met 
                805                 810                 815     


Glu Gly Val Gly Lys Pro Lys Ile Ile Asn Ser Phe Thr Gln Asp Asp 
            820                 825                 830         


Ile Glu Lys His Gln Ser Asp Ala Gly Leu Tyr Val Ile Val Pro Val 
        835                 840                 845             


Ile Ile Ser Ser Ser Ile Leu Leu Leu Gly Thr Leu Leu Ile Ser His 
    850                 855                 860                 


Gln Arg Met Lys Lys Leu Phe Trp Glu Asp Val Pro Asn Pro Lys Asn 
865                 870                 875                 880 


Cys Ser Trp Ala Gln Gly Leu Asn Phe Gln Lys Pro Glu Thr Phe Glu 
                885                 890                 895     


His Leu Phe Ile Lys His Thr Ala Ser Val Thr Cys Gly Pro Leu Leu 
            900                 905                 910         


Leu Glu Pro Glu Thr Ile Ser Glu Asp Ile Ser Val Asp Thr Ser Trp 
        915                 920                 925             


Lys Asn Lys Asp Glu Met Met Pro Thr Thr Val Val Ser Leu Leu Ser 
    930                 935                 940                 


Thr Thr Asp Leu Glu Lys Gly Ser Val Cys Ile Ser Asp Gln Phe Asn 
945                 950                 955                 960 


Ser Val Asn Phe Ser Glu Ala Glu Gly Thr Glu Val Thr Tyr Glu Asp 
                965                 970                 975     


Glu Ser Gln Arg Gln Pro Phe Val Lys Tyr Ala Thr Leu Ile Ser Asn 
            980                 985                 990         


Ser Lys Pro Ser Glu Thr Gly Glu  Glu Gln Gly Leu Ile  Asn Ser Ser 
        995                 1000                 1005             


Val Thr  Lys Cys Phe Ser Ser  Lys Asn Ser Pro Leu  Lys Asp Ser 
    1010                 1015                 1020             


Phe Ser  Asn Ser Ser Trp Glu  Ile Glu Ala Gln Ala  Phe Phe Ile 
    1025                 1030                 1035             


Leu Ser  Asp Gln His Pro Asn  Ile Ile Ser Pro His  Leu Thr Phe 
    1040                 1045                 1050             


Ser Glu  Gly Leu Asp Glu Leu  Leu Lys Leu Glu Gly  Asn Phe Pro 
    1055                 1060                 1065             


Glu Glu  Asn Asn Asp Lys Lys  Ser Ile Tyr Tyr Leu  Gly Val Thr 
    1070                 1075                 1080             


Ser Ile  Lys Lys Arg Glu Ser  Gly Val Leu Leu Thr  Asp Lys Ser 
    1085                 1090                 1095             


Arg Val  Ser Cys Pro Phe Pro  Ala Pro Cys Leu Phe  Thr Asp Ile 
    1100                 1105                 1110             


Arg Val  Leu Gln Asp Ser Cys  Ser His Phe Val Glu  Asn Asn Ile 
    1115                 1120                 1125             


Asn Leu  Gly Thr Ser Ser Lys  Lys Thr Phe Ala Ser  Tyr Met Pro 
    1130                 1135                 1140             


Gln Phe  Gln Thr Cys Ser Thr  Gln Thr His Lys Ile  Met Glu Asn 
    1145                 1150                 1155             


Lys Met  Cys Asp Leu Thr Val  
    1160                 1165 


<210>  240
<211>  906
<212>  PRT
<213>  Homo sapiens

<400>  240

Met Ile Cys Gln Lys Phe Cys Val Val Leu Leu His Trp Glu Phe Ile 
1               5                   10                  15      


Tyr Val Ile Thr Ala Phe Asn Leu Ser Tyr Pro Ile Thr Pro Trp Arg 
            20                  25                  30          


Phe Lys Leu Ser Cys Met Pro Pro Asn Ser Thr Tyr Asp Tyr Phe Leu 
        35                  40                  45              


Leu Pro Ala Gly Leu Ser Lys Asn Thr Ser Asn Ser Asn Gly His Tyr 
    50                  55                  60                  


Glu Thr Ala Val Glu Pro Lys Phe Asn Ser Ser Gly Thr His Phe Ser 
65                  70                  75                  80  


Asn Leu Ser Lys Thr Thr Phe His Cys Cys Phe Arg Ser Glu Gln Asp 
                85                  90                  95      


Arg Asn Cys Ser Leu Cys Ala Asp Asn Ile Glu Gly Lys Thr Phe Val 
            100                 105                 110         


Ser Thr Val Asn Ser Leu Val Phe Gln Gln Ile Asp Ala Asn Trp Asn 
        115                 120                 125             


Ile Gln Cys Trp Leu Lys Gly Asp Leu Lys Leu Phe Ile Cys Tyr Val 
    130                 135                 140                 


Glu Ser Leu Phe Lys Asn Leu Phe Arg Asn Tyr Asn Tyr Lys Val His 
145                 150                 155                 160 


Leu Leu Tyr Val Leu Pro Glu Val Leu Glu Asp Ser Pro Leu Val Pro 
                165                 170                 175     


Gln Lys Gly Ser Phe Gln Met Val His Cys Asn Cys Ser Val His Glu 
            180                 185                 190         


Cys Cys Glu Cys Leu Val Pro Val Pro Thr Ala Lys Leu Asn Asp Thr 
        195                 200                 205             


Leu Leu Met Cys Leu Lys Ile Thr Ser Gly Gly Val Ile Phe Gln Ser 
    210                 215                 220                 


Pro Leu Met Ser Val Gln Pro Ile Asn Met Val Lys Pro Asp Pro Pro 
225                 230                 235                 240 


Leu Gly Leu His Met Glu Ile Thr Asp Asp Gly Asn Leu Lys Ile Ser 
                245                 250                 255     


Trp Ser Ser Pro Pro Leu Val Pro Phe Pro Leu Gln Tyr Gln Val Lys 
            260                 265                 270         


Tyr Ser Glu Asn Ser Thr Thr Val Ile Arg Glu Ala Asp Lys Ile Val 
        275                 280                 285             


Ser Ala Thr Ser Leu Leu Val Asp Ser Ile Leu Pro Gly Ser Ser Tyr 
    290                 295                 300                 


Glu Val Gln Val Arg Gly Lys Arg Leu Asp Gly Pro Gly Ile Trp Ser 
305                 310                 315                 320 


Asp Trp Ser Thr Pro Arg Val Phe Thr Thr Gln Asp Val Ile Tyr Phe 
                325                 330                 335     


Pro Pro Lys Ile Leu Thr Ser Val Gly Ser Asn Val Ser Phe His Cys 
            340                 345                 350         


Ile Tyr Lys Lys Glu Asn Lys Ile Val Pro Ser Lys Glu Ile Val Trp 
        355                 360                 365             


Trp Met Asn Leu Ala Glu Lys Ile Pro Gln Ser Gln Tyr Asp Val Val 
    370                 375                 380                 


Ser Asp His Val Ser Lys Val Thr Phe Phe Asn Leu Asn Glu Thr Lys 
385                 390                 395                 400 


Pro Arg Gly Lys Phe Thr Tyr Asp Ala Val Tyr Cys Cys Asn Glu His 
                405                 410                 415     


Glu Cys His His Arg Tyr Ala Glu Leu Tyr Val Ile Asp Val Asn Ile 
            420                 425                 430         


Asn Ile Ser Cys Glu Thr Asp Gly Tyr Leu Thr Lys Met Thr Cys Arg 
        435                 440                 445             


Trp Ser Thr Ser Thr Ile Gln Ser Leu Ala Glu Ser Thr Leu Gln Leu 
    450                 455                 460                 


Arg Tyr His Arg Ser Ser Leu Tyr Cys Ser Asp Ile Pro Ser Ile His 
465                 470                 475                 480 


Pro Ile Ser Glu Pro Lys Asp Cys Tyr Leu Gln Ser Asp Gly Phe Tyr 
                485                 490                 495     


Glu Cys Ile Phe Gln Pro Ile Phe Leu Leu Ser Gly Tyr Thr Met Trp 
            500                 505                 510         


Ile Arg Ile Asn His Ser Leu Gly Ser Leu Asp Ser Pro Pro Thr Cys 
        515                 520                 525             


Val Leu Pro Asp Ser Val Val Lys Pro Leu Pro Pro Ser Ser Val Lys 
    530                 535                 540                 


Ala Glu Ile Thr Ile Asn Ile Gly Leu Leu Lys Ile Ser Trp Glu Lys 
545                 550                 555                 560 


Pro Val Phe Pro Glu Asn Asn Leu Gln Phe Gln Ile Arg Tyr Gly Leu 
                565                 570                 575     


Ser Gly Lys Glu Val Gln Trp Lys Met Tyr Glu Val Tyr Asp Ala Lys 
            580                 585                 590         


Ser Lys Ser Val Ser Leu Pro Val Pro Asp Leu Cys Ala Val Tyr Ala 
        595                 600                 605             


Val Gln Val Arg Cys Lys Arg Leu Asp Gly Leu Gly Tyr Trp Ser Asn 
    610                 615                 620                 


Trp Ser Asn Pro Ala Tyr Thr Val Val Met Asp Ile Lys Val Pro Met 
625                 630                 635                 640 


Arg Gly Pro Glu Phe Trp Arg Ile Ile Asn Gly Asp Thr Met Lys Lys 
                645                 650                 655     


Glu Lys Asn Val Thr Leu Leu Trp Lys Pro Leu Met Lys Asn Asp Ser 
            660                 665                 670         


Leu Cys Ser Val Gln Arg Tyr Val Ile Asn His His Thr Ser Cys Asn 
        675                 680                 685             


Gly Thr Trp Ser Glu Asp Val Gly Asn His Thr Lys Phe Thr Phe Leu 
    690                 695                 700                 


Trp Thr Glu Gln Ala His Thr Val Thr Val Leu Ala Ile Asn Ser Ile 
705                 710                 715                 720 


Gly Ala Ser Val Ala Asn Phe Asn Leu Thr Phe Ser Trp Pro Met Ser 
                725                 730                 735     


Lys Val Asn Ile Val Gln Ser Leu Ser Ala Tyr Pro Leu Asn Ser Ser 
            740                 745                 750         


Cys Val Ile Val Ser Trp Ile Leu Ser Pro Ser Asp Tyr Lys Leu Met 
        755                 760                 765             


Tyr Phe Ile Ile Glu Trp Lys Asn Leu Asn Glu Asp Gly Glu Ile Lys 
    770                 775                 780                 


Trp Leu Arg Ile Ser Ser Ser Val Lys Lys Tyr Tyr Ile His Asp His 
785                 790                 795                 800 


Phe Ile Pro Ile Glu Lys Tyr Gln Phe Ser Leu Tyr Pro Ile Phe Met 
                805                 810                 815     


Glu Gly Val Gly Lys Pro Lys Ile Ile Asn Ser Phe Thr Gln Asp Asp 
            820                 825                 830         


Ile Glu Lys His Gln Ser Asp Ala Gly Leu Tyr Val Ile Val Pro Val 
        835                 840                 845             


Ile Ile Ser Ser Ser Ile Leu Leu Leu Gly Thr Leu Leu Ile Ser His 
    850                 855                 860                 


Gln Arg Met Lys Lys Leu Phe Trp Glu Asp Val Pro Asn Pro Lys Asn 
865                 870                 875                 880 


Cys Ser Trp Ala Gln Gly Leu Asn Phe Gln Lys Lys Met Pro Gly Thr 
                885                 890                 895     


Lys Glu Leu Leu Gly Gly Gly Trp Leu Thr 
            900                 905     


<210>  241
<211>  958
<212>  PRT
<213>  Homo sapiens

<400>  241

Met Ile Cys Gln Lys Phe Cys Val Val Leu Leu His Trp Glu Phe Ile 
1               5                   10                  15      


Tyr Val Ile Thr Ala Phe Asn Leu Ser Tyr Pro Ile Thr Pro Trp Arg 
            20                  25                  30          


Phe Lys Leu Ser Cys Met Pro Pro Asn Ser Thr Tyr Asp Tyr Phe Leu 
        35                  40                  45              


Leu Pro Ala Gly Leu Ser Lys Asn Thr Ser Asn Ser Asn Gly His Tyr 
    50                  55                  60                  


Glu Thr Ala Val Glu Pro Lys Phe Asn Ser Ser Gly Thr His Phe Ser 
65                  70                  75                  80  


Asn Leu Ser Lys Thr Thr Phe His Cys Cys Phe Arg Ser Glu Gln Asp 
                85                  90                  95      


Arg Asn Cys Ser Leu Cys Ala Asp Asn Ile Glu Gly Lys Thr Phe Val 
            100                 105                 110         


Ser Thr Val Asn Ser Leu Val Phe Gln Gln Ile Asp Ala Asn Trp Asn 
        115                 120                 125             


Ile Gln Cys Trp Leu Lys Gly Asp Leu Lys Leu Phe Ile Cys Tyr Val 
    130                 135                 140                 


Glu Ser Leu Phe Lys Asn Leu Phe Arg Asn Tyr Asn Tyr Lys Val His 
145                 150                 155                 160 


Leu Leu Tyr Val Leu Pro Glu Val Leu Glu Asp Ser Pro Leu Val Pro 
                165                 170                 175     


Gln Lys Gly Ser Phe Gln Met Val His Cys Asn Cys Ser Val His Glu 
            180                 185                 190         


Cys Cys Glu Cys Leu Val Pro Val Pro Thr Ala Lys Leu Asn Asp Thr 
        195                 200                 205             


Leu Leu Met Cys Leu Lys Ile Thr Ser Gly Gly Val Ile Phe Gln Ser 
    210                 215                 220                 


Pro Leu Met Ser Val Gln Pro Ile Asn Met Val Lys Pro Asp Pro Pro 
225                 230                 235                 240 


Leu Gly Leu His Met Glu Ile Thr Asp Asp Gly Asn Leu Lys Ile Ser 
                245                 250                 255     


Trp Ser Ser Pro Pro Leu Val Pro Phe Pro Leu Gln Tyr Gln Val Lys 
            260                 265                 270         


Tyr Ser Glu Asn Ser Thr Thr Val Ile Arg Glu Ala Asp Lys Ile Val 
        275                 280                 285             


Ser Ala Thr Ser Leu Leu Val Asp Ser Ile Leu Pro Gly Ser Ser Tyr 
    290                 295                 300                 


Glu Val Gln Val Arg Gly Lys Arg Leu Asp Gly Pro Gly Ile Trp Ser 
305                 310                 315                 320 


Asp Trp Ser Thr Pro Arg Val Phe Thr Thr Gln Asp Val Ile Tyr Phe 
                325                 330                 335     


Pro Pro Lys Ile Leu Thr Ser Val Gly Ser Asn Val Ser Phe His Cys 
            340                 345                 350         


Ile Tyr Lys Lys Glu Asn Lys Ile Val Pro Ser Lys Glu Ile Val Trp 
        355                 360                 365             


Trp Met Asn Leu Ala Glu Lys Ile Pro Gln Ser Gln Tyr Asp Val Val 
    370                 375                 380                 


Ser Asp His Val Ser Lys Val Thr Phe Phe Asn Leu Asn Glu Thr Lys 
385                 390                 395                 400 


Pro Arg Gly Lys Phe Thr Tyr Asp Ala Val Tyr Cys Cys Asn Glu His 
                405                 410                 415     


Glu Cys His His Arg Tyr Ala Glu Leu Tyr Val Ile Asp Val Asn Ile 
            420                 425                 430         


Asn Ile Ser Cys Glu Thr Asp Gly Tyr Leu Thr Lys Met Thr Cys Arg 
        435                 440                 445             


Trp Ser Thr Ser Thr Ile Gln Ser Leu Ala Glu Ser Thr Leu Gln Leu 
    450                 455                 460                 


Arg Tyr His Arg Ser Ser Leu Tyr Cys Ser Asp Ile Pro Ser Ile His 
465                 470                 475                 480 


Pro Ile Ser Glu Pro Lys Asp Cys Tyr Leu Gln Ser Asp Gly Phe Tyr 
                485                 490                 495     


Glu Cys Ile Phe Gln Pro Ile Phe Leu Leu Ser Gly Tyr Thr Met Trp 
            500                 505                 510         


Ile Arg Ile Asn His Ser Leu Gly Ser Leu Asp Ser Pro Pro Thr Cys 
        515                 520                 525             


Val Leu Pro Asp Ser Val Val Lys Pro Leu Pro Pro Ser Ser Val Lys 
    530                 535                 540                 


Ala Glu Ile Thr Ile Asn Ile Gly Leu Leu Lys Ile Ser Trp Glu Lys 
545                 550                 555                 560 


Pro Val Phe Pro Glu Asn Asn Leu Gln Phe Gln Ile Arg Tyr Gly Leu 
                565                 570                 575     


Ser Gly Lys Glu Val Gln Trp Lys Met Tyr Glu Val Tyr Asp Ala Lys 
            580                 585                 590         


Ser Lys Ser Val Ser Leu Pro Val Pro Asp Leu Cys Ala Val Tyr Ala 
        595                 600                 605             


Val Gln Val Arg Cys Lys Arg Leu Asp Gly Leu Gly Tyr Trp Ser Asn 
    610                 615                 620                 


Trp Ser Asn Pro Ala Tyr Thr Val Val Met Asp Ile Lys Val Pro Met 
625                 630                 635                 640 


Arg Gly Pro Glu Phe Trp Arg Ile Ile Asn Gly Asp Thr Met Lys Lys 
                645                 650                 655     


Glu Lys Asn Val Thr Leu Leu Trp Lys Pro Leu Met Lys Asn Asp Ser 
            660                 665                 670         


Leu Cys Ser Val Gln Arg Tyr Val Ile Asn His His Thr Ser Cys Asn 
        675                 680                 685             


Gly Thr Trp Ser Glu Asp Val Gly Asn His Thr Lys Phe Thr Phe Leu 
    690                 695                 700                 


Trp Thr Glu Gln Ala His Thr Val Thr Val Leu Ala Ile Asn Ser Ile 
705                 710                 715                 720 


Gly Ala Ser Val Ala Asn Phe Asn Leu Thr Phe Ser Trp Pro Met Ser 
                725                 730                 735     


Lys Val Asn Ile Val Gln Ser Leu Ser Ala Tyr Pro Leu Asn Ser Ser 
            740                 745                 750         


Cys Val Ile Val Ser Trp Ile Leu Ser Pro Ser Asp Tyr Lys Leu Met 
        755                 760                 765             


Tyr Phe Ile Ile Glu Trp Lys Asn Leu Asn Glu Asp Gly Glu Ile Lys 
    770                 775                 780                 


Trp Leu Arg Ile Ser Ser Ser Val Lys Lys Tyr Tyr Ile His Asp His 
785                 790                 795                 800 


Phe Ile Pro Ile Glu Lys Tyr Gln Phe Ser Leu Tyr Pro Ile Phe Met 
                805                 810                 815     


Glu Gly Val Gly Lys Pro Lys Ile Ile Asn Ser Phe Thr Gln Asp Asp 
            820                 825                 830         


Ile Glu Lys His Gln Ser Asp Ala Gly Leu Tyr Val Ile Val Pro Val 
        835                 840                 845             


Ile Ile Ser Ser Ser Ile Leu Leu Leu Gly Thr Leu Leu Ile Ser His 
    850                 855                 860                 


Gln Arg Met Lys Lys Leu Phe Trp Glu Asp Val Pro Asn Pro Lys Asn 
865                 870                 875                 880 


Cys Ser Trp Ala Gln Gly Leu Asn Phe Gln Lys Met Leu Glu Gly Ser 
                885                 890                 895     


Met Phe Val Lys Ser His His His Ser Leu Ile Ser Ser Thr Gln Gly 
            900                 905                 910         


His Lys His Cys Gly Arg Pro Gln Gly Pro Leu His Arg Lys Thr Arg 
        915                 920                 925             


Asp Leu Cys Ser Leu Val Tyr Leu Leu Thr Leu Pro Pro Leu Leu Ser 
    930                 935                 940                 


Tyr Asp Pro Ala Lys Ser Pro Ser Val Arg Asn Thr Gln Glu 
945                 950                 955             


<210>  242
<211>  896
<212>  PRT
<213>  Homo sapiens

<400>  242

Met Ile Cys Gln Lys Phe Cys Val Val Leu Leu His Trp Glu Phe Ile 
1               5                   10                  15      


Tyr Val Ile Thr Ala Phe Asn Leu Ser Tyr Pro Ile Thr Pro Trp Arg 
            20                  25                  30          


Phe Lys Leu Ser Cys Met Pro Pro Asn Ser Thr Tyr Asp Tyr Phe Leu 
        35                  40                  45              


Leu Pro Ala Gly Leu Ser Lys Asn Thr Ser Asn Ser Asn Gly His Tyr 
    50                  55                  60                  


Glu Thr Ala Val Glu Pro Lys Phe Asn Ser Ser Gly Thr His Phe Ser 
65                  70                  75                  80  


Asn Leu Ser Lys Thr Thr Phe His Cys Cys Phe Arg Ser Glu Gln Asp 
                85                  90                  95      


Arg Asn Cys Ser Leu Cys Ala Asp Asn Ile Glu Gly Lys Thr Phe Val 
            100                 105                 110         


Ser Thr Val Asn Ser Leu Val Phe Gln Gln Ile Asp Ala Asn Trp Asn 
        115                 120                 125             


Ile Gln Cys Trp Leu Lys Gly Asp Leu Lys Leu Phe Ile Cys Tyr Val 
    130                 135                 140                 


Glu Ser Leu Phe Lys Asn Leu Phe Arg Asn Tyr Asn Tyr Lys Val His 
145                 150                 155                 160 


Leu Leu Tyr Val Leu Pro Glu Val Leu Glu Asp Ser Pro Leu Val Pro 
                165                 170                 175     


Gln Lys Gly Ser Phe Gln Met Val His Cys Asn Cys Ser Val His Glu 
            180                 185                 190         


Cys Cys Glu Cys Leu Val Pro Val Pro Thr Ala Lys Leu Asn Asp Thr 
        195                 200                 205             


Leu Leu Met Cys Leu Lys Ile Thr Ser Gly Gly Val Ile Phe Gln Ser 
    210                 215                 220                 


Pro Leu Met Ser Val Gln Pro Ile Asn Met Val Lys Pro Asp Pro Pro 
225                 230                 235                 240 


Leu Gly Leu His Met Glu Ile Thr Asp Asp Gly Asn Leu Lys Ile Ser 
                245                 250                 255     


Trp Ser Ser Pro Pro Leu Val Pro Phe Pro Leu Gln Tyr Gln Val Lys 
            260                 265                 270         


Tyr Ser Glu Asn Ser Thr Thr Val Ile Arg Glu Ala Asp Lys Ile Val 
        275                 280                 285             


Ser Ala Thr Ser Leu Leu Val Asp Ser Ile Leu Pro Gly Ser Ser Tyr 
    290                 295                 300                 


Glu Val Gln Val Arg Gly Lys Arg Leu Asp Gly Pro Gly Ile Trp Ser 
305                 310                 315                 320 


Asp Trp Ser Thr Pro Arg Val Phe Thr Thr Gln Asp Val Ile Tyr Phe 
                325                 330                 335     


Pro Pro Lys Ile Leu Thr Ser Val Gly Ser Asn Val Ser Phe His Cys 
            340                 345                 350         


Ile Tyr Lys Lys Glu Asn Lys Ile Val Pro Ser Lys Glu Ile Val Trp 
        355                 360                 365             


Trp Met Asn Leu Ala Glu Lys Ile Pro Gln Ser Gln Tyr Asp Val Val 
    370                 375                 380                 


Ser Asp His Val Ser Lys Val Thr Phe Phe Asn Leu Asn Glu Thr Lys 
385                 390                 395                 400 


Pro Arg Gly Lys Phe Thr Tyr Asp Ala Val Tyr Cys Cys Asn Glu His 
                405                 410                 415     


Glu Cys His His Arg Tyr Ala Glu Leu Tyr Val Ile Asp Val Asn Ile 
            420                 425                 430         


Asn Ile Ser Cys Glu Thr Asp Gly Tyr Leu Thr Lys Met Thr Cys Arg 
        435                 440                 445             


Trp Ser Thr Ser Thr Ile Gln Ser Leu Ala Glu Ser Thr Leu Gln Leu 
    450                 455                 460                 


Arg Tyr His Arg Ser Ser Leu Tyr Cys Ser Asp Ile Pro Ser Ile His 
465                 470                 475                 480 


Pro Ile Ser Glu Pro Lys Asp Cys Tyr Leu Gln Ser Asp Gly Phe Tyr 
                485                 490                 495     


Glu Cys Ile Phe Gln Pro Ile Phe Leu Leu Ser Gly Tyr Thr Met Trp 
            500                 505                 510         


Ile Arg Ile Asn His Ser Leu Gly Ser Leu Asp Ser Pro Pro Thr Cys 
        515                 520                 525             


Val Leu Pro Asp Ser Val Val Lys Pro Leu Pro Pro Ser Ser Val Lys 
    530                 535                 540                 


Ala Glu Ile Thr Ile Asn Ile Gly Leu Leu Lys Ile Ser Trp Glu Lys 
545                 550                 555                 560 


Pro Val Phe Pro Glu Asn Asn Leu Gln Phe Gln Ile Arg Tyr Gly Leu 
                565                 570                 575     


Ser Gly Lys Glu Val Gln Trp Lys Met Tyr Glu Val Tyr Asp Ala Lys 
            580                 585                 590         


Ser Lys Ser Val Ser Leu Pro Val Pro Asp Leu Cys Ala Val Tyr Ala 
        595                 600                 605             


Val Gln Val Arg Cys Lys Arg Leu Asp Gly Leu Gly Tyr Trp Ser Asn 
    610                 615                 620                 


Trp Ser Asn Pro Ala Tyr Thr Val Val Met Asp Ile Lys Val Pro Met 
625                 630                 635                 640 


Arg Gly Pro Glu Phe Trp Arg Ile Ile Asn Gly Asp Thr Met Lys Lys 
                645                 650                 655     


Glu Lys Asn Val Thr Leu Leu Trp Lys Pro Leu Met Lys Asn Asp Ser 
            660                 665                 670         


Leu Cys Ser Val Gln Arg Tyr Val Ile Asn His His Thr Ser Cys Asn 
        675                 680                 685             


Gly Thr Trp Ser Glu Asp Val Gly Asn His Thr Lys Phe Thr Phe Leu 
    690                 695                 700                 


Trp Thr Glu Gln Ala His Thr Val Thr Val Leu Ala Ile Asn Ser Ile 
705                 710                 715                 720 


Gly Ala Ser Val Ala Asn Phe Asn Leu Thr Phe Ser Trp Pro Met Ser 
                725                 730                 735     


Lys Val Asn Ile Val Gln Ser Leu Ser Ala Tyr Pro Leu Asn Ser Ser 
            740                 745                 750         


Cys Val Ile Val Ser Trp Ile Leu Ser Pro Ser Asp Tyr Lys Leu Met 
        755                 760                 765             


Tyr Phe Ile Ile Glu Trp Lys Asn Leu Asn Glu Asp Gly Glu Ile Lys 
    770                 775                 780                 


Trp Leu Arg Ile Ser Ser Ser Val Lys Lys Tyr Tyr Ile His Asp His 
785                 790                 795                 800 


Phe Ile Pro Ile Glu Lys Tyr Gln Phe Ser Leu Tyr Pro Ile Phe Met 
                805                 810                 815     


Glu Gly Val Gly Lys Pro Lys Ile Ile Asn Ser Phe Thr Gln Asp Asp 
            820                 825                 830         


Ile Glu Lys His Gln Ser Asp Ala Gly Leu Tyr Val Ile Val Pro Val 
        835                 840                 845             


Ile Ile Ser Ser Ser Ile Leu Leu Leu Gly Thr Leu Leu Ile Ser His 
    850                 855                 860                 


Gln Arg Met Lys Lys Leu Phe Trp Glu Asp Val Pro Asn Pro Lys Asn 
865                 870                 875                 880 


Cys Ser Trp Ala Gln Gly Leu Asn Phe Gln Lys Arg Thr Asp Ile Leu 
                885                 890                 895     


<210>  243
<211>  232
<212>  PRT
<213>  Homo sapiens

<400>  243

Met Met Pro Thr Thr Val Val Ser Leu Leu Ser Thr Thr Asp Leu Glu 
1               5                   10                  15      


Lys Gly Ser Val Cys Ile Ser Asp Gln Phe Asn Ser Val Asn Phe Ser 
            20                  25                  30          


Glu Ala Glu Gly Thr Glu Val Thr Tyr Glu Asp Glu Ser Gln Arg Gln 
        35                  40                  45              


Pro Phe Val Lys Tyr Ala Thr Leu Ile Ser Asn Ser Lys Pro Ser Glu 
    50                  55                  60                  


Thr Gly Glu Glu Gln Gly Leu Ile Asn Ser Ser Val Thr Lys Cys Phe 
65                  70                  75                  80  


Ser Ser Lys Asn Ser Pro Leu Lys Asp Ser Phe Ser Asn Ser Ser Trp 
                85                  90                  95      


Glu Ile Glu Ala Gln Ala Phe Phe Ile Leu Ser Asp Gln His Pro Asn 
            100                 105                 110         


Ile Ile Ser Pro His Leu Thr Phe Ser Glu Gly Leu Asp Glu Leu Leu 
        115                 120                 125             


Lys Leu Glu Gly Asn Phe Pro Glu Glu Asn Asn Asp Lys Lys Ser Ile 
    130                 135                 140                 


Tyr Tyr Leu Gly Val Thr Ser Ile Lys Lys Arg Glu Ser Gly Val Leu 
145                 150                 155                 160 


Leu Thr Asp Lys Ser Arg Val Ser Cys Pro Phe Pro Ala Pro Cys Leu 
                165                 170                 175     


Phe Thr Asp Ile Arg Val Leu Gln Asp Ser Cys Ser His Phe Val Glu 
            180                 185                 190         


Asn Asn Ile Asn Leu Gly Thr Ser Ser Lys Lys Thr Phe Ala Ser Tyr 
        195                 200                 205             


Met Pro Gln Phe Gln Thr Cys Ser Thr Gln Thr His Lys Ile Met Glu 
    210                 215                 220                 


Asn Lys Met Cys Asp Leu Thr Val 
225                 230         


<210>  244
<211>  896
<212>  PRT
<213>  Homo sapiens

<400>  244

Met Ile Cys Gln Lys Phe Cys Val Val Leu Leu His Trp Glu Phe Ile 
1               5                   10                  15      


Tyr Val Ile Thr Ala Phe Asn Leu Ser Tyr Pro Ile Thr Pro Trp Arg 
            20                  25                  30          


Phe Lys Leu Ser Cys Met Pro Pro Asn Ser Thr Tyr Asp Tyr Phe Leu 
        35                  40                  45              


Leu Pro Ala Gly Leu Ser Lys Asn Thr Ser Asn Ser Asn Gly His Tyr 
    50                  55                  60                  


Glu Thr Ala Val Glu Pro Lys Phe Asn Ser Ser Gly Thr His Phe Ser 
65                  70                  75                  80  


Asn Leu Ser Lys Thr Thr Phe His Cys Cys Phe Arg Ser Glu Gln Asp 
                85                  90                  95      


Arg Asn Cys Ser Leu Cys Ala Asp Asn Ile Glu Gly Lys Thr Phe Val 
            100                 105                 110         


Ser Thr Val Asn Ser Leu Val Phe Gln Gln Ile Asp Ala Asn Trp Asn 
        115                 120                 125             


Ile Gln Cys Trp Leu Lys Gly Asp Leu Lys Leu Phe Ile Cys Tyr Val 
    130                 135                 140                 


Glu Ser Leu Phe Lys Asn Leu Phe Arg Asn Tyr Asn Tyr Lys Val His 
145                 150                 155                 160 


Leu Leu Tyr Val Leu Pro Glu Val Leu Glu Asp Ser Pro Leu Val Pro 
                165                 170                 175     


Gln Lys Gly Ser Phe Gln Met Val His Cys Asn Cys Ser Val His Glu 
            180                 185                 190         


Cys Cys Glu Cys Leu Val Pro Val Pro Thr Ala Lys Leu Asn Asp Thr 
        195                 200                 205             


Leu Leu Met Cys Leu Lys Ile Thr Ser Gly Gly Val Ile Phe Gln Ser 
    210                 215                 220                 


Pro Leu Met Ser Val Gln Pro Ile Asn Met Val Lys Pro Asp Pro Pro 
225                 230                 235                 240 


Leu Gly Leu His Met Glu Ile Thr Asp Asp Gly Asn Leu Lys Ile Ser 
                245                 250                 255     


Trp Ser Ser Pro Pro Leu Val Pro Phe Pro Leu Gln Tyr Gln Val Lys 
            260                 265                 270         


Tyr Ser Glu Asn Ser Thr Thr Val Ile Arg Glu Ala Asp Lys Ile Val 
        275                 280                 285             


Ser Ala Thr Ser Leu Leu Val Asp Ser Ile Leu Pro Gly Ser Ser Tyr 
    290                 295                 300                 


Glu Val Gln Val Arg Gly Lys Arg Leu Asp Gly Pro Gly Ile Trp Ser 
305                 310                 315                 320 


Asp Trp Ser Thr Pro Arg Val Phe Thr Thr Gln Asp Val Ile Tyr Phe 
                325                 330                 335     


Pro Pro Lys Ile Leu Thr Ser Val Gly Ser Asn Val Ser Phe His Cys 
            340                 345                 350         


Ile Tyr Lys Lys Glu Asn Lys Ile Val Pro Ser Lys Glu Ile Val Trp 
        355                 360                 365             


Trp Met Asn Leu Ala Glu Lys Ile Pro Gln Ser Gln Tyr Asp Val Val 
    370                 375                 380                 


Ser Asp His Val Ser Lys Val Thr Phe Phe Asn Leu Asn Glu Thr Lys 
385                 390                 395                 400 


Pro Arg Gly Lys Phe Thr Tyr Asp Ala Val Tyr Cys Cys Asn Glu His 
                405                 410                 415     


Glu Cys His His Arg Tyr Ala Glu Leu Tyr Val Ile Asp Val Asn Ile 
            420                 425                 430         


Asn Ile Ser Cys Glu Thr Asp Gly Tyr Leu Thr Lys Met Thr Cys Arg 
        435                 440                 445             


Trp Ser Thr Ser Thr Ile Gln Ser Leu Ala Glu Ser Thr Leu Gln Leu 
    450                 455                 460                 


Arg Tyr His Arg Ser Ser Leu Tyr Cys Ser Asp Ile Pro Ser Ile His 
465                 470                 475                 480 


Pro Ile Ser Glu Pro Lys Asp Cys Tyr Leu Gln Ser Asp Gly Phe Tyr 
                485                 490                 495     


Glu Cys Ile Phe Gln Pro Ile Phe Leu Leu Ser Gly Tyr Thr Met Trp 
            500                 505                 510         


Ile Arg Ile Asn His Ser Leu Gly Ser Leu Asp Ser Pro Pro Thr Cys 
        515                 520                 525             


Val Leu Pro Asp Ser Val Val Lys Pro Leu Pro Pro Ser Ser Val Lys 
    530                 535                 540                 


Ala Glu Ile Thr Ile Asn Ile Gly Leu Leu Lys Ile Ser Trp Glu Lys 
545                 550                 555                 560 


Pro Val Phe Pro Glu Asn Asn Leu Gln Phe Gln Ile Arg Tyr Gly Leu 
                565                 570                 575     


Ser Gly Lys Glu Val Gln Trp Lys Met Tyr Glu Val Tyr Asp Ala Lys 
            580                 585                 590         


Ser Lys Ser Val Ser Leu Pro Val Pro Asp Leu Cys Ala Val Tyr Ala 
        595                 600                 605             


Val Gln Val Arg Cys Lys Arg Leu Asp Gly Leu Gly Tyr Trp Ser Asn 
    610                 615                 620                 


Trp Ser Asn Pro Ala Tyr Thr Val Val Met Asp Ile Lys Val Pro Met 
625                 630                 635                 640 


Arg Gly Pro Glu Phe Trp Arg Ile Ile Asn Gly Asp Thr Met Lys Lys 
                645                 650                 655     


Glu Lys Asn Val Thr Leu Leu Trp Lys Pro Leu Met Lys Asn Asp Ser 
            660                 665                 670         


Leu Cys Ser Val Gln Arg Tyr Val Ile Asn His His Thr Ser Cys Asn 
        675                 680                 685             


Gly Thr Trp Ser Glu Asp Val Gly Asn His Thr Lys Phe Thr Phe Leu 
    690                 695                 700                 


Trp Thr Glu Gln Ala His Thr Val Thr Val Leu Ala Ile Asn Ser Ile 
705                 710                 715                 720 


Gly Ala Ser Val Ala Asn Phe Asn Leu Thr Phe Ser Trp Pro Met Ser 
                725                 730                 735     


Lys Val Asn Ile Val Gln Ser Leu Ser Ala Tyr Pro Leu Asn Ser Ser 
            740                 745                 750         


Cys Val Ile Val Ser Trp Ile Leu Ser Pro Ser Asp Tyr Lys Leu Met 
        755                 760                 765             


Tyr Phe Ile Ile Glu Trp Lys Asn Leu Asn Glu Asp Gly Glu Ile Lys 
    770                 775                 780                 


Trp Leu Arg Ile Ser Ser Ser Val Lys Lys Tyr Tyr Ile His Asp His 
785                 790                 795                 800 


Phe Ile Pro Ile Glu Lys Tyr Gln Phe Ser Leu Tyr Pro Ile Phe Met 
                805                 810                 815     


Glu Gly Val Gly Lys Pro Lys Ile Ile Asn Ser Phe Thr Gln Asp Asp 
            820                 825                 830         


Ile Glu Lys His Gln Ser Asp Ala Gly Leu Tyr Val Ile Val Pro Val 
        835                 840                 845             


Ile Ile Ser Ser Ser Ile Leu Leu Leu Gly Thr Leu Leu Ile Ser His 
    850                 855                 860                 


Gln Arg Met Lys Lys Leu Phe Trp Glu Asp Val Pro Asn Pro Lys Asn 
865                 870                 875                 880 


Cys Ser Trp Ala Gln Gly Leu Asn Phe Gln Lys Arg Thr Asp Ile Leu 
                885                 890                 895     


<210>  245
<211>  214
<212>  PRT
<213>  Homo sapiens

<400>  245

Met Gly Leu Arg Asp Trp Leu Arg Thr Val Cys Cys Cys Cys Gly Cys 
1               5                   10                  15      


Glu Cys Leu Glu Glu Arg Ala Leu Pro Glu Lys Glu Pro Leu Val Ser 
            20                  25                  30          


Asp Asn Asn Pro Tyr Ser Ser Phe Gly Ala Thr Leu Val Arg Asp Asp 
        35                  40                  45              


Glu Lys Asn Leu Trp Ser Met Pro His Asp Val Ser His Thr Glu Ala 
    50                  55                  60                  


Asp Asp Asp Arg Thr Leu Tyr Asn Leu Ile Val Ile Arg Asn Gln Gln 
65                  70                  75                  80  


Ala Lys Asp Ser Glu Glu Trp Gln Lys Leu Asn Tyr Asp Ile His Thr 
                85                  90                  95      


Leu Arg Gln Val Arg Arg Glu Val Arg Asn Arg Trp Lys Cys Ile Leu 
            100                 105                 110         


Glu Asp Leu Gly Phe Gln Lys Glu Ala Asp Ser Leu Leu Ser Val Thr 
        115                 120                 125             


Lys Leu Ser Thr Ile Ser Asp Ser Lys Asn Thr Arg Lys Ala Arg Glu 
    130                 135                 140                 


Met Leu Leu Lys Leu Ala Glu Glu Thr Asn Ile Phe Pro Thr Ser Trp 
145                 150                 155                 160 


Glu Leu Ser Glu Arg Tyr Leu Phe Val Val Asp Arg Leu Ile Ala Leu 
                165                 170                 175     


Asp Ala Ala Glu Glu Phe Phe Lys Leu Ala Arg Arg Thr Tyr Pro Lys 
            180                 185                 190         


Lys Pro Gly Val Pro Cys Leu Ala Asp Gly Gln Lys Glu Leu His Tyr 
        195                 200                 205             


Leu Pro Phe Pro Ser Pro 
    210                 


<210>  246
<211>  214
<212>  PRT
<213>  Homo sapiens

<400>  246

Met Gly Leu Arg Asp Trp Leu Arg Thr Val Cys Cys Cys Cys Gly Cys 
1               5                   10                  15      


Glu Cys Leu Glu Glu Arg Ala Leu Pro Glu Lys Glu Pro Leu Val Ser 
            20                  25                  30          


Asp Asn Asn Pro Tyr Ser Ser Phe Gly Ala Thr Leu Val Arg Asp Asp 
        35                  40                  45              


Glu Lys Asn Leu Trp Ser Met Pro His Asp Val Ser His Thr Glu Ala 
    50                  55                  60                  


Asp Asp Asp Arg Thr Leu Tyr Asn Leu Ile Val Ile Arg Asn Gln Gln 
65                  70                  75                  80  


Ala Lys Asp Ser Glu Glu Trp Gln Lys Leu Asn Tyr Asp Ile His Thr 
                85                  90                  95      


Leu Arg Gln Val Arg Arg Glu Val Arg Asn Arg Trp Lys Cys Ile Leu 
            100                 105                 110         


Glu Asp Leu Gly Phe Gln Lys Glu Ala Asp Ser Leu Leu Ser Val Thr 
        115                 120                 125             


Lys Leu Ser Thr Ile Ser Asp Ser Lys Asn Thr Arg Lys Ala Arg Glu 
    130                 135                 140                 


Met Leu Leu Lys Leu Ala Glu Glu Thr Asn Ile Phe Pro Thr Ser Trp 
145                 150                 155                 160 


Glu Leu Ser Glu Arg Tyr Leu Phe Val Val Asp Arg Leu Ile Ala Leu 
                165                 170                 175     


Asp Ala Ala Glu Glu Phe Phe Lys Leu Ala Arg Arg Thr Tyr Pro Lys 
            180                 185                 190         


Lys Pro Gly Val Pro Cys Leu Ala Asp Gly Gln Lys Glu Leu His Tyr 
        195                 200                 205             


Leu Pro Phe Pro Ser Pro 
    210                 


<210>  247
<211>  526
<212>  PRT
<213>  Homo sapiens

<400>  247

Met Val Asn Glu Gly Pro Asn Gln Glu Glu Ser Asp Asp Thr Pro Val 
1               5                   10                  15      


Pro Glu Ser Ala Leu Gln Ala Asp Pro Ser Val Ser Val His Pro Ser 
            20                  25                  30          


Val Ser Val His Pro Ser Val Ser Ile Asn Pro Ser Val Ser Val His 
        35                  40                  45              


Pro Ser Ser Ser Ala His Pro Ser Ala Leu Ala Gln Pro Ser Gly Leu 
    50                  55                  60                  


Ala His Pro Ser Ser Ser Gly Pro Glu Asp Leu Ser Val Ile Lys Val 
65                  70                  75                  80  


Ser Arg Arg Arg Trp Ala Val Val Leu Val Phe Ser Cys Tyr Ser Met 
                85                  90                  95      


Cys Asn Ser Phe Gln Trp Ile Gln Tyr Gly Ser Ile Asn Asn Ile Phe 
            100                 105                 110         


Met His Phe Tyr Gly Val Ser Ala Phe Ala Ile Asp Trp Leu Ser Met 
        115                 120                 125             


Cys Tyr Met Leu Thr Tyr Ile Pro Leu Leu Leu Pro Val Ala Trp Leu 
    130                 135                 140                 


Leu Glu Lys Phe Gly Leu Arg Thr Ile Ala Leu Thr Gly Ser Ala Leu 
145                 150                 155                 160 


Asn Cys Leu Gly Ala Trp Val Lys Leu Gly Ser Leu Lys Pro His Leu 
                165                 170                 175     


Phe Pro Val Thr Val Val Gly Gln Leu Ile Cys Ser Val Ala Gln Val 
            180                 185                 190         


Phe Ile Leu Gly Met Pro Ser Arg Ile Ala Ser Val Trp Phe Gly Ala 
        195                 200                 205             


Asn Glu Val Ser Thr Ala Cys Ser Val Ala Val Phe Gly Asn Gln Leu 
    210                 215                 220                 


Gly Ile Ala Ile Gly Phe Leu Val Pro Pro Val Leu Val Pro Asn Ile 
225                 230                 235                 240 


Glu Asp Arg Asp Glu Leu Ala Tyr His Ile Ser Ile Met Phe Tyr Ile 
                245                 250                 255     


Ile Gly Gly Val Ala Thr Leu Leu Leu Ile Leu Val Ile Ile Val Phe 
            260                 265                 270         


Lys Glu Lys Pro Lys Tyr Pro Pro Ser Arg Ala Gln Ser Leu Ser Tyr 
        275                 280                 285             


Ala Leu Thr Ser Pro Asp Ala Ser Tyr Leu Gly Ser Ile Ala Arg Leu 
    290                 295                 300                 


Phe Lys Asn Leu Asn Phe Val Leu Leu Val Ile Thr Tyr Gly Leu Asn 
305                 310                 315                 320 


Ala Gly Ala Phe Tyr Ala Leu Ser Thr Leu Leu Asn Arg Met Val Ile 
                325                 330                 335     


Trp His Tyr Pro Gly Glu Glu Val Asn Ala Gly Arg Ile Gly Leu Thr 
            340                 345                 350         


Ile Val Ile Ala Gly Met Leu Gly Ala Val Ile Ser Gly Ile Trp Leu 
        355                 360                 365             


Asp Arg Ser Lys Thr Tyr Lys Glu Thr Thr Leu Val Val Tyr Ile Met 
    370                 375                 380                 


Thr Leu Val Gly Met Val Val Tyr Thr Phe Thr Leu Asn Leu Gly His 
385                 390                 395                 400 


Leu Trp Val Val Phe Ile Thr Ala Gly Thr Met Gly Phe Phe Met Thr 
                405                 410                 415     


Gly Tyr Leu Pro Leu Gly Phe Glu Phe Ala Val Glu Leu Thr Tyr Pro 
            420                 425                 430         


Glu Ser Glu Gly Ile Ser Ser Gly Leu Leu Asn Ile Ser Ala Gln Val 
        435                 440                 445             


Phe Gly Ile Ile Phe Thr Ile Ser Gln Gly Gln Ile Ile Asp Asn Tyr 
    450                 455                 460                 


Gly Thr Lys Pro Gly Asn Ile Phe Leu Cys Val Phe Leu Thr Leu Gly 
465                 470                 475                 480 


Ala Ala Leu Thr Ala Phe Ile Lys Ala Asp Leu Arg Arg Gln Lys Ala 
                485                 490                 495     


Asn Lys Glu Thr Leu Glu Asn Lys Leu Gln Glu Glu Glu Glu Glu Ser 
            500                 505                 510         


Asn Thr Ser Lys Val Pro Thr Ala Val Ser Glu Asp His Leu 
        515                 520                 525     


<210>  248
<211>  321
<212>  PRT
<213>  Homo sapiens

<400>  248

Met Ser Ala Asp Asn Ser Ser Thr Ile Cys Val Cys Arg Ser Val Arg 
1               5                   10                  15      


Gln Glu Leu Gly Ile Ala Ile Gly Phe Leu Val Pro Pro Val Leu Val 
            20                  25                  30          


Pro Asn Ile Glu Asp Arg Asp Glu Leu Ala Tyr His Ile Ser Ile Met 
        35                  40                  45              


Phe Tyr Ile Ile Gly Gly Val Ala Thr Leu Leu Leu Ile Leu Val Ile 
    50                  55                  60                  


Ile Val Phe Lys Glu Lys Pro Lys Tyr Pro Pro Ser Arg Ala Gln Ser 
65                  70                  75                  80  


Leu Ser Tyr Ala Leu Thr Ser Pro Asp Ala Ser Tyr Leu Gly Ser Ile 
                85                  90                  95      


Ala Arg Leu Phe Lys Asn Leu Asn Phe Val Leu Leu Val Ile Thr Tyr 
            100                 105                 110         


Gly Leu Asn Ala Gly Ala Phe Tyr Ala Leu Ser Thr Leu Leu Asn Arg 
        115                 120                 125             


Met Val Ile Trp His Tyr Pro Gly Glu Glu Val Asn Ala Gly Arg Ile 
    130                 135                 140                 


Gly Leu Thr Ile Val Ile Ala Gly Met Leu Gly Ala Val Ile Ser Gly 
145                 150                 155                 160 


Ile Trp Leu Asp Arg Ser Lys Thr Tyr Lys Glu Thr Thr Leu Val Val 
                165                 170                 175     


Tyr Ile Met Thr Leu Val Gly Met Val Val Tyr Thr Phe Thr Leu Asn 
            180                 185                 190         


Leu Gly His Leu Trp Val Val Phe Ile Thr Ala Gly Thr Met Gly Phe 
        195                 200                 205             


Phe Met Thr Gly Tyr Leu Pro Leu Gly Phe Glu Phe Ala Val Glu Leu 
    210                 215                 220                 


Thr Tyr Pro Glu Ser Glu Gly Ile Ser Ser Gly Leu Leu Asn Ile Ser 
225                 230                 235                 240 


Ala Gln Val Phe Gly Ile Ile Phe Thr Ile Ser Gln Gly Gln Ile Ile 
                245                 250                 255     


Asp Asn Tyr Gly Thr Lys Pro Gly Asn Ile Phe Leu Cys Val Phe Leu 
            260                 265                 270         


Thr Leu Gly Ala Ala Leu Thr Ala Phe Ile Lys Ala Asp Leu Arg Arg 
        275                 280                 285             


Gln Lys Ala Asn Lys Glu Thr Leu Glu Asn Lys Leu Gln Glu Glu Glu 
    290                 295                 300                 


Glu Glu Ser Asn Thr Ser Lys Val Pro Thr Ala Val Ser Glu Asp His 
305                 310                 315                 320 


Leu 
    


<210>  249
<211>  203
<212>  PRT
<213>  Homo sapiens

<400>  249

Met Phe Tyr Ile Ile Gly Gly Val Ala Thr Leu Leu Leu Ile Leu Val 
1               5                   10                  15      


Ile Ile Gly Leu Asn Ala Gly Ala Phe Tyr Ala Leu Ser Thr Leu Leu 
            20                  25                  30          


Asn Arg Met Val Ile Trp His Tyr Pro Gly Glu Glu Val Asn Ala Gly 
        35                  40                  45              


Arg Ile Gly Leu Thr Ile Val Ile Ala Gly Met Leu Gly Ala Val Ile 
    50                  55                  60                  


Ser Gly Ile Trp Leu Asp Arg Ser Lys Thr Tyr Lys Glu Thr Thr Leu 
65                  70                  75                  80  


Val Val Tyr Ile Met Thr Leu Val Gly Met Val Val Tyr Thr Phe Thr 
                85                  90                  95      


Leu Asn Leu Gly His Leu Trp Val Val Phe Ile Thr Ala Gly Thr Met 
            100                 105                 110         


Gly Phe Phe Met Thr Gly Tyr Leu Pro Leu Gly Phe Glu Phe Ala Val 
        115                 120                 125             


Glu Leu Thr Tyr Pro Glu Ser Glu Gly Ile Ser Ser Gly Leu Leu Asn 
    130                 135                 140                 


Ile Ser Ala Gln Val Phe Gly Ile Ile Phe Thr Ile Ser Gln Gly Gln 
145                 150                 155                 160 


Ile Ile Asp Asn Tyr Gly Thr Lys Pro Gly Asn Ile Phe Leu Cys Val 
                165                 170                 175     


Phe Leu Thr Leu Gly Ala Ala Leu Thr Ala Phe Ile Lys Ala Asp Leu 
            180                 185                 190         


Arg Arg Gln Lys Ala Asn Lys Glu Thr Leu Glu 
        195                 200             


<210>  250
<211>  133
<212>  PRT
<213>  Homo sapiens

<400>  250

Met Phe Tyr Ile Ile Gly Gly Val Ala Thr Leu Leu Leu Ile Leu Val 
1               5                   10                  15      


Ile Ile Val Phe Lys Glu Lys Pro Lys Tyr Pro Pro Ser Arg Ala Gln 
            20                  25                  30          


Ser Leu Ser Tyr Ala Leu Thr Ser Pro Asp Ala Ser Tyr Leu Gly Ser 
        35                  40                  45              


Ile Ala Arg Leu Phe Lys Asn Leu Asn Phe Val Leu Leu Val Ile Thr 
    50                  55                  60                  


Tyr Gly Leu Asn Ala Gly Ala Phe Tyr Ala Leu Ser Thr Leu Leu Asn 
65                  70                  75                  80  


Arg Met Val Ile Trp His Tyr Pro Gly Glu Glu Val Asn Ala Gly Arg 
                85                  90                  95      


Ile Gly Leu Thr Ile Val Ile Ala Gly Met Leu Gly Ala Val Ile Ser 
            100                 105                 110         


Gly Ile Trp Leu Asp Arg Ser Lys Thr Tyr Lys Asn Leu Cys His Pro 
        115                 120                 125             


Asn Cys Leu Ile Gln 
    130             


<210>  251
<211>  203
<212>  PRT
<213>  Homo sapiens

<400>  251

Met Ser Pro Tyr Gly Ile Ser Ser Leu Gly Asn Gly Leu Ser Lys Trp 
1               5                   10                  15      


Leu Ser Leu Asn Ala Gly Ala Phe Tyr Ala Leu Ser Thr Leu Leu Asn 
            20                  25                  30          


Arg Met Val Ile Trp His Tyr Pro Gly Glu Glu Val Asn Ala Gly Arg 
        35                  40                  45              


Ile Gly Leu Thr Ile Val Ile Ala Gly Met Leu Gly Ala Val Ile Ser 
    50                  55                  60                  


Gly Ile Trp Leu Asp Arg Ser Lys Thr Tyr Lys Glu Thr Thr Leu Val 
65                  70                  75                  80  


Val Tyr Ile Met Thr Leu Val Gly Met Val Val Tyr Thr Phe Thr Leu 
                85                  90                  95      


Asn Leu Gly His Leu Trp Val Val Phe Ile Thr Ala Gly Thr Met Gly 
            100                 105                 110         


Phe Phe Met Thr Gly Tyr Leu Pro Leu Gly Phe Glu Phe Ala Val Glu 
        115                 120                 125             


Leu Thr Tyr Pro Glu Ser Glu Gly Ile Ser Ser Gly Leu Leu Asn Ile 
    130                 135                 140                 


Ser Ala Gln Val Phe Gly Ile Ile Phe Thr Ile Ser Gln Gly Gln Ile 
145                 150                 155                 160 


Ile Asp Asn Tyr Gly Thr Lys Pro Gly Asn Ile Phe Leu Cys Val Phe 
                165                 170                 175     


Leu Thr Leu Gly Ala Ala Leu Thr Ala Phe Ile Lys Ala Asp Leu Arg 
            180                 185                 190         


Arg Gln Lys Ala Asn Lys Glu Thr Leu Glu Asn 
        195                 200             


<210>  252
<211>  241
<212>  PRT
<213>  Homo sapiens

<400>  252

Met Cys Pro Asp Leu His Pro Ser Lys Tyr Val Gln Pro Pro Leu Ser 
1               5                   10                  15      


Ser Ser Ser Ser Pro Leu Lys Gly Gly Gln Glu Ala Phe Ser Pro Leu 
            20                  25                  30          


Gly Leu Asn Ala Gly Ala Phe Tyr Ala Leu Ser Thr Leu Leu Asn Arg 
        35                  40                  45              


Met Val Ile Trp His Tyr Pro Gly Glu Glu Val Asn Ala Gly Arg Ile 
    50                  55                  60                  


Gly Leu Thr Ile Val Ile Ala Gly Met Leu Gly Ala Val Ile Ser Gly 
65                  70                  75                  80  


Ile Trp Leu Asp Arg Ser Lys Thr Tyr Lys Glu Thr Thr Leu Val Val 
                85                  90                  95      


Tyr Ile Met Thr Leu Val Gly Met Val Val Tyr Thr Phe Thr Leu Asn 
            100                 105                 110         


Leu Gly His Leu Trp Val Val Phe Ile Thr Ala Gly Thr Met Gly Phe 
        115                 120                 125             


Phe Met Thr Gly Tyr Leu Pro Leu Gly Phe Glu Phe Ala Val Glu Leu 
    130                 135                 140                 


Thr Tyr Pro Glu Ser Glu Gly Ile Ser Ser Gly Leu Leu Asn Ile Ser 
145                 150                 155                 160 


Ala Gln Val Phe Gly Ile Ile Phe Thr Ile Ser Gln Gly Gln Ile Ile 
                165                 170                 175     


Asp Asn Tyr Gly Thr Lys Pro Gly Asn Ile Phe Leu Cys Val Phe Leu 
            180                 185                 190         


Thr Leu Gly Ala Ala Leu Thr Ala Phe Ile Lys Ala Asp Leu Arg Arg 
        195                 200                 205             


Gln Lys Ala Asn Lys Glu Thr Leu Glu Asn Lys Leu Gln Glu Glu Glu 
    210                 215                 220                 


Glu Glu Ser Asn Thr Ser Lys Val Pro Thr Ala Val Ser Glu Asp His 
225                 230                 235                 240 


Leu 
    


<210>  253
<211>  88
<212>  PRT
<213>  Homo sapiens

<400>  253

Met Phe Tyr Ile Ile Gly Gly Val Ala Thr Leu Leu Leu Ile Leu Val 
1               5                   10                  15      


Ile Ile Val Phe Lys Glu Lys Pro Lys Tyr Pro Pro Ser Arg Ala Gln 
            20                  25                  30          


Ser Leu Ser Tyr Ala Leu Thr Ser Pro Asp Ala Ser Tyr Leu Gly Ser 
        35                  40                  45              


Ile Ala Arg Leu Phe Lys Asn Leu Asn Phe Val Leu Leu Val Ile Thr 
    50                  55                  60                  


Tyr Gly Leu Asn Ala Gly Ala Phe Tyr Ala Leu Ser Thr Leu Leu Asn 
65                  70                  75                  80  


Arg Met Val Ile Trp His Tyr Pro 
                85              


<210>  254
<211>  93
<212>  PRT
<213>  Homo sapiens

<400>  254

Met Phe Tyr Ile Ile Gly Gly Val Ala Thr Leu Leu Leu Ile Leu Val 
1               5                   10                  15      


Ile Ile Val Phe Lys Glu Lys Pro Lys Tyr Pro Pro Ser Arg Ala Gln 
            20                  25                  30          


Ser Leu Ser Tyr Ala Leu Thr Ser Pro Asp Ala Ser Tyr Leu Gly Ser 
        35                  40                  45              


Ile Ala Arg Leu Phe Lys Asn Leu Asn Phe Val Leu Leu Val Ile Thr 
    50                  55                  60                  


Tyr Glu Thr Pro Arg Gly Gly Gly Gly Glu Gln His Gln Gln Ser Ala 
65                  70                  75                  80  


His Cys Cys Val Arg Gly Ser Ser Leu Arg Gly Arg Trp 
                85                  90              


<210>  255
<211>  102
<212>  PRT
<213>  Homo sapiens

<400>  255

Met Thr Leu Arg Cys Leu Glu Pro Ser Gly Asn Gly Gly Glu Gly Thr 
1               5                   10                  15      


Arg Ser Gln Trp Gly Thr Ala Gly Ser Ala Glu Glu Pro Ser Pro Gln 
            20                  25                  30          


Ala Ala Arg Leu Ala Lys Ala Leu Arg Glu Leu Gly Gln Thr Gly Arg 
        35                  40                  45              


Glu Pro Ile Gly Arg Asp Ala Cys Gly Arg Glu Arg Leu Pro Lys Glu 
    50                  55                  60                  


Ala Ala Arg Lys Arg Gly Arg Gly Gly Lys Gln Arg Ile Arg Trp Lys 
65                  70                  75                  80  


Tyr Val Pro Cys Phe Gln Gly Thr Ala Glu Ser Thr Leu Ala Gly Ser 
                85                  90                  95      


Trp Val Leu Gly Asn Ala 
            100         


<210>  256
<211>  46
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  256

Xaa Ala Pro Ser Leu Gln His Leu Cys Arg Leu Thr Ile Asn Lys Cys 
1               5                   10                  15      


Thr Gly Ala Ile Trp Gly Leu Pro Leu Pro Thr Arg Leu Lys Asp Tyr 
            20                  25                  30          


Leu Glu Glu Tyr Lys Phe Gln Pro Ala Val Phe Tyr Pro Gly 
        35                  40                  45      


<210>  257
<211>  341
<212>  PRT
<213>  Homo sapiens

<400>  257

Met Asn Ile Val Val Glu Phe Phe Val Val Thr Phe Lys Val Leu Trp 
1               5                   10                  15      


Ala Phe Val Leu Ala Ala Ala Arg Trp Leu Val Arg Pro Lys Glu Lys 
            20                  25                  30          


Ser Val Ala Gly Gln Val Cys Leu Ile Thr Gly Ala Gly Ser Gly Leu 
        35                  40                  45              


Gly Arg Leu Phe Ala Leu Glu Phe Ala Arg Arg Arg Ala Leu Leu Val 
    50                  55                  60                  


Leu Trp Asp Ile Asn Thr Gln Ser Asn Glu Glu Thr Ala Gly Met Val 
65                  70                  75                  80  


Arg His Ile Tyr Arg Asp Leu Glu Ala Ala Asp Ala Ala Ala Leu Gln 
                85                  90                  95      


Ala Gly Asn Gly Glu Glu Glu Ile Leu Pro His Cys Asn Leu Gln Val 
            100                 105                 110         


Phe Thr Tyr Thr Cys Asp Val Gly Lys Arg Glu Asn Val Tyr Leu Thr 
        115                 120                 125             


Ala Glu Arg Val Arg Lys Glu Val Gly Glu Val Ser Val Leu Val Asn 
    130                 135                 140                 


Asn Ala Gly Val Val Ser Gly His His Leu Leu Glu Cys Pro Asp Glu 
145                 150                 155                 160 


Leu Ile Glu Arg Thr Met Met Val Asn Cys His Ala His Phe Trp Thr 
                165                 170                 175     


Thr Lys Ala Phe Leu Pro Thr Met Leu Glu Ile Asn His Gly His Ile 
            180                 185                 190         


Val Thr Val Ala Ser Ser Leu Gly Leu Phe Ser Thr Ala Gly Val Glu 
        195                 200                 205             


Asp Tyr Cys Ala Ser Lys Phe Gly Val Val Gly Phe His Glu Ser Leu 
    210                 215                 220                 


Ser His Glu Leu Lys Ala Ala Glu Lys Asp Gly Ile Lys Thr Thr Leu 
225                 230                 235                 240 


Val Cys Pro Tyr Leu Val Asp Thr Gly Met Phe Arg Gly Cys Arg Ile 
                245                 250                 255     


Arg Lys Glu Ile Glu Pro Phe Leu Pro Pro Leu Lys Pro Asp Tyr Cys 
            260                 265                 270         


Val Lys Gln Ala Met Lys Ala Ile Leu Thr Asp Gln Pro Met Ile Cys 
        275                 280                 285             


Thr Pro Arg Leu Met Tyr Ile Val Thr Phe Met Lys Ser Ile Leu Pro 
    290                 295                 300                 


Phe Glu Ala Val Val Cys Met Tyr Arg Phe Leu Gly Ala Asp Lys Cys 
305                 310                 315                 320 


Met Tyr Pro Phe Ile Ala Gln Arg Lys Gln Ala Thr Asn Asn Asn Glu 
                325                 330                 335     


Ala Lys Asn Gly Ile 
            340     


<210>  258
<211>  176
<212>  PRT
<213>  Homo sapiens

<400>  258

Met Met Val Asn Cys His Ala His Phe Trp Thr Thr Lys Ala Phe Leu 
1               5                   10                  15      


Pro Thr Met Leu Glu Ile Asn His Gly His Ile Val Thr Val Ala Ser 
            20                  25                  30          


Ser Leu Gly Leu Phe Ser Thr Ala Gly Val Glu Asp Tyr Cys Ala Ser 
        35                  40                  45              


Lys Phe Gly Val Val Gly Phe His Glu Ser Leu Ser His Glu Leu Lys 
    50                  55                  60                  


Ala Ala Glu Lys Asp Gly Ile Lys Thr Thr Leu Val Cys Pro Tyr Leu 
65                  70                  75                  80  


Val Asp Thr Gly Met Phe Arg Gly Cys Arg Ile Arg Lys Glu Ile Glu 
                85                  90                  95      


Pro Phe Leu Pro Pro Leu Lys Pro Asp Tyr Cys Val Lys Gln Ala Met 
            100                 105                 110         


Lys Ala Ile Leu Thr Asp Gln Pro Met Ile Cys Thr Pro Arg Leu Met 
        115                 120                 125             


Tyr Ile Val Thr Phe Met Lys Ser Ile Leu Pro Phe Glu Ala Val Val 
    130                 135                 140                 


Cys Met Tyr Arg Phe Leu Gly Ala Asp Lys Cys Met Tyr Pro Phe Ile 
145                 150                 155                 160 


Ala Gln Arg Lys Gln Ala Thr Asn Asn Asn Glu Ala Lys Asn Gly Ile 
                165                 170                 175     


<210>  259
<211>  62
<212>  PRT
<213>  Homo sapiens

<400>  259

Met Met Val Asn Cys His Ala His Phe Trp Thr Thr Lys Ala Phe Leu 
1               5                   10                  15      


Pro Thr Met Leu Glu Ile Asn His Gly His Ile Val Thr Val Ala Ser 
            20                  25                  30          


Ser Leu Gly Leu Phe Ser Thr Ala Gly Val Glu Asp Tyr Cys Ala Ser 
        35                  40                  45              


Lys Phe Gly Val Val Gly Phe His Glu Ser Leu Ser His Glu 
    50                  55                  60          


<210>  260
<211>  382
<212>  PRT
<213>  Homo sapiens

<400>  260

Met Arg Ser His Phe Leu Gln Trp Ala Leu Ala Thr Ser Arg Asn Lys 
1               5                   10                  15      


Asp Gln Ile Thr Asn Ile Phe Ser Gly Phe Ala Gly Leu Leu Ala Ile 
            20                  25                  30          


Leu Leu Val Val Ala Val Phe Cys Ile Leu Trp Asn Trp Asn Lys Arg 
        35                  40                  45              


Lys Lys Arg Gln Val Pro Tyr Leu Arg Val Thr Val Met Pro Leu Leu 
    50                  55                  60                  


Thr Leu Pro Gln Thr Arg Gln Arg Ala Lys Asn Ile Tyr Asp Ile Leu 
65                  70                  75                  80  


Pro Trp Arg Gln Glu Asp Leu Gly Arg His Glu Ser Arg Ser Met Arg 
                85                  90                  95      


Ile Phe Ser Thr Glu Ser Leu Leu Ser Arg Asn Ser Glu Ser Pro Glu 
            100                 105                 110         


His Val Pro Ser Gln Ala Gly Asn Ala Phe Gln Glu His Thr Ala His 
        115                 120                 125             


Ile His Ala Thr Glu Tyr Ala Val Gly Ile Tyr Asp Asn Ala Met Val 
    130                 135                 140                 


Pro Gln Met Cys Gly Asn Leu Thr Pro Ser Ala His Cys Ile Asn Val 
145                 150                 155                 160 


Arg Ala Ser Arg Asp Cys Ala Ser Ile Ser Ser Glu Asp Ser His Asp 
                165                 170                 175     


Tyr Val Asn Val Pro Thr Ala Glu Glu Ile Ala Glu Thr Leu Ala Ser 
            180                 185                 190         


Thr Lys Ser Pro Ser Arg Asn Leu Phe Val Leu Pro Ser Thr Gln Lys 
        195                 200                 205             


Leu Glu Phe Thr Glu Glu Arg Asp Glu Gly Cys Gly Asp Ala Gly Asp 
    210                 215                 220                 


Cys Thr Ser Leu Tyr Ser Pro Gly Ala Glu Asp Ser Asp Ser Leu Ser 
225                 230                 235                 240 


Asn Gly Glu Gly Ser Ser Gln Ile Ser Asn Asp Tyr Val Asn Met Thr 
                245                 250                 255     


Gly Leu Asp Leu Ser Ala Ile Gln Glu Arg Gln Leu Trp Val Ala Phe 
            260                 265                 270         


Gln Cys Cys Arg Asp Tyr Glu Asn Val Pro Ala Ala Asp Pro Ser Gly 
        275                 280                 285             


Ser Gln Gln Gln Ala Glu Lys Asp Val Pro Ser Ser Asn Ile Gly His 
    290                 295                 300                 


Val Glu Asp Lys Thr Asp Asp Pro Gly Thr His Val Gln Cys Val Lys 
305                 310                 315                 320 


Arg Thr Phe Leu Ala Ser Gly Asp Tyr Ala Asp Phe Gln Pro Phe Thr 
                325                 330                 335     


Gln Ser Glu Asp Ser Gln Met Lys His Arg Glu Glu Met Ser Asn Glu 
            340                 345                 350         


Asp Ser Ser Asp Tyr Glu Asn Val Leu Thr Ala Lys Leu Gly Gly Arg 
        355                 360                 365             


Asp Ser Glu Gln Gly Pro Gly Thr Gln Leu Leu Pro Asp Glu 
    370                 375                 380         


<210>  261
<211>  398
<212>  PRT
<213>  Homo sapiens

<400>  261

Met Asp Gly Val Thr Pro Thr Leu Ser Thr Ile Arg Gly Arg Thr Leu 
1               5                   10                  15      


Glu Ser Ser Thr Leu His Val Thr Pro Arg Ser Leu Asp Arg Asn Lys 
            20                  25                  30          


Asp Gln Ile Thr Asn Ile Phe Ser Gly Phe Ala Gly Leu Leu Ala Ile 
        35                  40                  45              


Leu Leu Val Val Ala Val Phe Cys Ile Leu Trp Asn Trp Asn Lys Arg 
    50                  55                  60                  


Lys Lys Arg Gln Val Pro Tyr Leu Arg Val Thr Val Met Pro Leu Leu 
65                  70                  75                  80  


Thr Leu Pro Gln Thr Arg Gln Arg Ala Lys Asn Ile Tyr Asp Ile Leu 
                85                  90                  95      


Pro Trp Arg Gln Glu Asp Leu Gly Arg His Glu Ser Arg Ser Met Arg 
            100                 105                 110         


Ile Phe Ser Thr Glu Ser Leu Leu Ser Arg Asn Ser Glu Ser Pro Glu 
        115                 120                 125             


His Val Pro Ser Gln Ala Gly Asn Ala Phe Gln Glu His Thr Ala His 
    130                 135                 140                 


Ile His Ala Thr Glu Tyr Ala Val Gly Ile Tyr Asp Asn Ala Met Val 
145                 150                 155                 160 


Pro Gln Met Cys Gly Asn Leu Thr Pro Ser Ala His Cys Ile Asn Val 
                165                 170                 175     


Arg Ala Ser Arg Asp Cys Ala Ser Ile Ser Ser Glu Asp Ser His Asp 
            180                 185                 190         


Tyr Val Asn Val Pro Thr Ala Glu Glu Ile Ala Glu Thr Leu Ala Ser 
        195                 200                 205             


Thr Lys Ser Pro Ser Arg Asn Leu Phe Val Leu Pro Ser Thr Gln Lys 
    210                 215                 220                 


Leu Glu Phe Thr Glu Glu Arg Asp Glu Gly Cys Gly Asp Ala Gly Asp 
225                 230                 235                 240 


Cys Thr Ser Leu Tyr Ser Pro Gly Ala Glu Asp Ser Asp Ser Leu Ser 
                245                 250                 255     


Asn Gly Glu Gly Ser Ser Gln Ile Ser Asn Asp Tyr Val Asn Met Thr 
            260                 265                 270         


Gly Leu Asp Leu Ser Ala Ile Gln Glu Arg Gln Leu Trp Val Ala Phe 
        275                 280                 285             


Gln Cys Cys Arg Asp Tyr Glu Asn Val Pro Ala Ala Asp Pro Ser Gly 
    290                 295                 300                 


Ser Gln Gln Gln Ala Glu Lys Asp Val Pro Ser Ser Asn Ile Gly His 
305                 310                 315                 320 


Val Glu Asp Lys Thr Asp Asp Pro Gly Thr His Val Gln Cys Val Lys 
                325                 330                 335     


Arg Thr Phe Leu Ala Ser Gly Asp Tyr Ala Asp Phe Gln Pro Phe Thr 
            340                 345                 350         


Gln Ser Glu Asp Ser Gln Met Lys His Arg Glu Glu Met Ser Asn Glu 
        355                 360                 365             


Asp Ser Ser Asp Tyr Glu Asn Val Leu Thr Ala Lys Leu Gly Gly Arg 
    370                 375                 380                 


Asp Ser Glu Gln Gly Pro Gly Thr Gln Leu Leu Pro Asp Glu 
385                 390                 395             


<210>  262
<211>  48
<212>  PRT
<213>  Homo sapiens

<400>  262

Met Glu Ala Ala Glu Thr Glu Ala Glu Ala Ala Ala Leu Glu Val Leu 
1               5                   10                  15      


Ala Glu Val Ala Gly Ile Leu Glu Pro Val Gly Leu Gln Glu Glu Ala 
            20                  25                  30          


Glu Leu Pro Ala Lys Ile Leu Val Glu Phe Val Val Val Cys Thr Arg 
        35                  40                  45              


<210>  263
<211>  439
<212>  PRT
<213>  Homo sapiens

<400>  263

Met Arg Arg Ala Ala Leu Arg Leu Cys Ala Leu Gly Lys Gly Gln Leu 
1               5                   10                  15      


Thr Pro Gly Arg Gly Leu Thr Gln Gly Pro Gln Asn Pro Lys Lys Gln 
            20                  25                  30          


Gly Ile Phe His Ile His Glu Val Arg Asp Lys Leu Arg Glu Ile Val 
        35                  40                  45              


Gly Ala Ser Thr Asn Trp Arg Asp His Val Lys Ala Met Glu Glu Arg 
    50                  55                  60                  


Lys Leu Leu His Ser Phe Leu Ala Lys Ser Gln Asp Gly Leu Pro Pro 
65                  70                  75                  80  


Arg Arg Met Lys Asp Ser Tyr Ile Glu Val Leu Leu Pro Leu Gly Ser 
                85                  90                  95      


Glu Pro Glu Leu Arg Glu Lys Tyr Leu Thr Val Gln Asn Thr Val Arg 
            100                 105                 110         


Phe Gly Arg Ile Leu Glu Asp Leu Asp Ser Leu Gly Val Leu Ile Cys 
        115                 120                 125             


Tyr Met His Asn Lys Ile His Ser Ala Lys Met Ser Pro Leu Ser Ile 
    130                 135                 140                 


Val Thr Ala Leu Val Asp Lys Ile Asp Met Cys Lys Lys Ser Leu Ser 
145                 150                 155                 160 


Pro Glu Gln Asp Ile Lys Phe Ser Gly His Val Ser Trp Val Gly Lys 
                165                 170                 175     


Thr Ser Met Glu Val Lys Met Gln Met Phe Gln Leu His Gly Asp Glu 
            180                 185                 190         


Phe Cys Pro Val Leu Asp Ala Thr Phe Val Met Val Ala Arg Asp Ser 
        195                 200                 205             


Glu Asn Lys Gly Pro Ala Phe Val Asn Pro Leu Ile Pro Glu Ser Pro 
    210                 215                 220                 


Glu Glu Glu Glu Leu Phe Arg Gln Gly Glu Leu Asn Lys Gly Arg Arg 
225                 230                 235                 240 


Ile Ala Phe Ser Ser Thr Ser Leu Leu Lys Met Ala Pro Ser Ala Glu 
                245                 250                 255     


Glu Arg Thr Thr Ile His Glu Met Phe Leu Ser Thr Leu Asp Pro Lys 
            260                 265                 270         


Thr Ile Ser Phe Arg Ser Arg Val Leu Pro Ser Asn Ala Val Trp Met 
        275                 280                 285             


Glu Asn Ser Lys Leu Lys Ser Leu Glu Ile Cys His Pro Gln Glu Arg 
    290                 295                 300                 


Asn Ile Phe Asn Arg Ile Phe Gly Gly Phe Leu Met Arg Lys Ala Tyr 
305                 310                 315                 320 


Glu Leu Ala Trp Ala Thr Ala Cys Ser Phe Gly Gly Ser Arg Pro Phe 
                325                 330                 335     


Val Val Ala Val Asp Asp Ile Met Phe Gln Lys Pro Val Glu Val Gly 
            340                 345                 350         


Ser Leu Leu Phe Leu Ser Ser Gln Val Cys Phe Thr Gln Asn Asn Tyr 
        355                 360                 365             


Ile Gln Val Arg Val His Ser Glu Val Ala Ser Leu Gln Glu Lys Gln 
    370                 375                 380                 


His Thr Thr Thr Asn Val Phe His Phe Thr Phe Met Ser Glu Lys Glu 
385                 390                 395                 400 


Val Pro Leu Val Phe Pro Lys Thr Tyr Gly Glu Ser Met Leu Tyr Leu 
                405                 410                 415     


Asp Gly Gln Arg His Phe Asn Ser Met Ser Gly Pro Ala Thr Leu Arg 
            420                 425                 430         


Lys Asp Tyr Leu Val Glu Pro 
        435                 


<210>  264
<211>  448
<212>  PRT
<213>  Homo sapiens

<400>  264

Met Arg Arg Ala Ala Leu Arg Leu Cys Ala Leu Gly Lys Gly Gln Leu 
1               5                   10                  15      


Thr Pro Gly Arg Gly Leu Thr Gln Gly Pro Gln Asn Pro Lys Lys Gln 
            20                  25                  30          


Gly Ile Phe His Ile His Glu Ala Cys Ser Ser Ile His Val Asn His 
        35                  40                  45              


Val Arg Asp Lys Leu Arg Glu Ile Val Gly Ala Ser Thr Asn Trp Arg 
    50                  55                  60                  


Asp His Val Lys Ala Met Glu Glu Arg Lys Leu Leu His Ser Phe Leu 
65                  70                  75                  80  


Ala Lys Ser Gln Asp Gly Leu Pro Pro Arg Arg Met Lys Asp Ser Tyr 
                85                  90                  95      


Ile Glu Val Leu Leu Pro Leu Gly Ser Glu Pro Glu Leu Arg Glu Lys 
            100                 105                 110         


Tyr Leu Thr Val Gln Asn Thr Val Arg Phe Gly Arg Ile Leu Glu Asp 
        115                 120                 125             


Leu Asp Ser Leu Gly Val Leu Ile Cys Tyr Met His Asn Lys Ile His 
    130                 135                 140                 


Ser Ala Lys Met Ser Pro Leu Ser Ile Val Thr Ala Leu Val Asp Lys 
145                 150                 155                 160 


Ile Asp Met Cys Lys Lys Ser Leu Ser Pro Glu Gln Asp Ile Lys Phe 
                165                 170                 175     


Ser Gly His Val Ser Trp Val Gly Lys Thr Ser Met Glu Val Lys Met 
            180                 185                 190         


Gln Met Phe Gln Leu His Gly Asp Glu Phe Cys Pro Val Leu Asp Ala 
        195                 200                 205             


Thr Phe Val Met Val Ala Arg Asp Ser Glu Asn Lys Gly Pro Ala Phe 
    210                 215                 220                 


Val Asn Pro Leu Ile Pro Glu Ser Pro Glu Glu Glu Glu Leu Phe Arg 
225                 230                 235                 240 


Gln Gly Glu Leu Asn Lys Gly Arg Arg Ile Ala Phe Ser Ser Thr Ser 
                245                 250                 255     


Leu Leu Lys Met Ala Pro Ser Ala Glu Glu Arg Thr Thr Ile His Glu 
            260                 265                 270         


Met Phe Leu Ser Thr Leu Asp Pro Lys Thr Ile Ser Phe Arg Ser Arg 
        275                 280                 285             


Val Leu Pro Ser Asn Ala Val Trp Met Glu Asn Ser Lys Leu Lys Ser 
    290                 295                 300                 


Leu Glu Ile Cys His Pro Gln Glu Arg Asn Ile Phe Asn Arg Ile Phe 
305                 310                 315                 320 


Gly Gly Phe Leu Met Arg Lys Ala Tyr Glu Leu Ala Trp Ala Thr Ala 
                325                 330                 335     


Cys Ser Phe Gly Gly Ser Arg Pro Phe Val Val Ala Val Asp Asp Ile 
            340                 345                 350         


Met Phe Gln Lys Pro Val Glu Val Gly Ser Leu Leu Phe Leu Ser Ser 
        355                 360                 365             


Gln Val Cys Phe Thr Gln Asn Asn Tyr Ile Gln Val Arg Val His Ser 
    370                 375                 380                 


Glu Val Ala Ser Leu Gln Glu Lys Gln His Thr Thr Thr Asn Val Phe 
385                 390                 395                 400 


His Phe Thr Phe Met Ser Glu Lys Glu Val Pro Leu Val Phe Pro Lys 
                405                 410                 415     


Thr Tyr Gly Glu Ser Met Leu Tyr Leu Asp Gly Gln Arg His Phe Asn 
            420                 425                 430         


Ser Met Ser Gly Pro Ala Thr Leu Arg Lys Asp Tyr Leu Val Glu Pro 
        435                 440                 445             


<210>  265
<211>  46
<212>  PRT
<213>  Homo sapiens

<400>  265

Met Arg Arg Ala Ala Leu Arg Leu Cys Ala Leu Gly Lys Gly Gln Leu 
1               5                   10                  15      


Thr Pro Gly Arg Gly Leu Thr Gln Gly Pro Gln Asn Pro Lys Lys Gln 
            20                  25                  30          


Gly Ile Phe His Ile His Glu Gly Lys His Gly Val Ser Val 
        35                  40                  45      


<210>  266
<211>  663
<212>  PRT
<213>  Homo sapiens

<400>  266

Met Ser Ala Arg Leu Pro Val Leu Ser Pro Pro Arg Trp Pro Arg Leu 
1               5                   10                  15      


Leu Leu Leu Ser Leu Leu Leu Leu Gly Ala Val Pro Gly Pro Arg Arg 
            20                  25                  30          


Ser Gly Ala Phe Tyr Leu Pro Gly Leu Ala Pro Val Asn Phe Cys Asp 
        35                  40                  45              


Glu Glu Lys Lys Ser Asp Glu Cys Lys Ala Glu Ile Glu Leu Phe Val 
    50                  55                  60                  


Asn Arg Leu Asp Ser Val Glu Ser Val Leu Pro Tyr Glu Tyr Thr Ala 
65                  70                  75                  80  


Phe Asp Phe Cys Gln Ala Ser Glu Gly Lys Arg Pro Ser Glu Asn Leu 
                85                  90                  95      


Gly Gln Val Leu Phe Gly Glu Arg Ile Glu Pro Ser Pro Tyr Lys Phe 
            100                 105                 110         


Thr Phe Asn Lys Lys Glu Thr Cys Lys Leu Val Cys Thr Lys Thr Tyr 
        115                 120                 125             


His Thr Glu Lys Ala Glu Asp Lys Gln Lys Leu Glu Phe Leu Lys Lys 
    130                 135                 140                 


Ser Met Leu Leu Asn Tyr Gln His His Trp Ile Val Asp Asn Met Pro 
145                 150                 155                 160 


Val Thr Trp Cys Tyr Asp Val Glu Asp Gly Gln Arg Phe Cys Asn Pro 
                165                 170                 175     


Gly Phe Pro Ile Gly Cys Tyr Ile Thr Asp Lys Gly His Ala Lys Asp 
            180                 185                 190         


Ala Cys Val Ile Ser Ser Asp Phe His Glu Arg Asp Thr Phe Tyr Ile 
        195                 200                 205             


Phe Asn His Val Asp Ile Lys Ile Tyr Tyr His Val Val Glu Thr Gly 
    210                 215                 220                 


Ser Met Gly Ala Arg Leu Val Ala Ala Lys Leu Glu Pro Lys Ser Phe 
225                 230                 235                 240 


Lys His Thr His Ile Asp Lys Pro Asp Cys Ser Gly Pro Pro Met Asp 
                245                 250                 255     


Ile Ser Asn Lys Ala Ser Gly Glu Ile Lys Ile Ala Tyr Thr Tyr Ser 
            260                 265                 270         


Val Ser Phe Glu Glu Asp Asp Lys Ile Arg Trp Ala Ser Arg Trp Asp 
        275                 280                 285             


Tyr Ile Leu Glu Ser Met Pro His Thr His Ile Gln Trp Phe Ser Ile 
    290                 295                 300                 


Met Asn Ser Leu Val Ile Val Leu Phe Leu Ser Gly Met Val Ala Met 
305                 310                 315                 320 


Ile Met Leu Arg Thr Leu His Lys Asp Ile Ala Arg Tyr Asn Gln Met 
                325                 330                 335     


Asp Ser Thr Glu Asp Ala Gln Glu Glu Phe Gly Trp Lys Leu Val His 
            340                 345                 350         


Gly Asp Ile Phe Arg Pro Pro Arg Lys Gly Met Leu Leu Ser Val Phe 
        355                 360                 365             


Leu Gly Ser Gly Thr Gln Ile Leu Ile Met Thr Phe Val Thr Leu Phe 
    370                 375                 380                 


Phe Ala Cys Leu Gly Phe Leu Ser Pro Ala Asn Arg Gly Ala Leu Met 
385                 390                 395                 400 


Thr Cys Ala Val Val Leu Trp Val Leu Leu Gly Thr Pro Ala Gly Tyr 
                405                 410                 415     


Val Ala Ala Arg Phe Tyr Lys Ser Phe Gly Gly Glu Lys Trp Lys Thr 
            420                 425                 430         


Asn Val Leu Leu Thr Ser Phe Leu Cys Pro Gly Ile Val Phe Ala Asp 
        435                 440                 445             


Phe Phe Ile Met Asn Leu Ile Leu Trp Gly Glu Gly Ser Ser Ala Ala 
    450                 455                 460                 


Ile Pro Phe Gly Thr Leu Val Ala Ile Leu Ala Leu Trp Phe Cys Ile 
465                 470                 475                 480 


Ser Val Pro Leu Thr Phe Ile Gly Ala Tyr Phe Gly Phe Lys Lys Asn 
                485                 490                 495     


Ala Ile Glu His Pro Val Arg Thr Asn Gln Ile Pro Arg Gln Ile Pro 
            500                 505                 510         


Glu Gln Ser Phe Tyr Thr Lys Pro Leu Pro Gly Ile Ile Met Gly Gly 
        515                 520                 525             


Ile Leu Pro Phe Gly Cys Ile Phe Ile Gln Leu Phe Phe Ile Leu Asn 
    530                 535                 540                 


Ser Ile Trp Ser His Gln Met Tyr Tyr Met Phe Gly Phe Leu Phe Leu 
545                 550                 555                 560 


Val Phe Ile Ile Leu Val Ile Thr Cys Ser Glu Ala Thr Ile Leu Leu 
                565                 570                 575     


Cys Tyr Phe His Leu Cys Ala Glu Asp Tyr His Trp Gln Trp Arg Ser 
            580                 585                 590         


Phe Leu Thr Ser Gly Phe Thr Ala Val Tyr Phe Leu Ile Tyr Ala Val 
        595                 600                 605             


His Tyr Phe Phe Ser Lys Leu Gln Ile Thr Gly Thr Ala Ser Thr Ile 
    610                 615                 620                 


Leu Tyr Phe Gly Tyr Thr Met Ile Met Val Leu Ile Phe Phe Leu Phe 
625                 630                 635                 640 


Thr Gly Thr Ile Gly Phe Phe Ala Cys Phe Trp Phe Val Thr Lys Ile 
                645                 650                 655     


Tyr Ser Val Val Lys Val Asp 
            660             


<210>  267
<211>  390
<212>  PRT
<213>  Homo sapiens

<400>  267

Met Gly Gln Arg Leu Ser Gly Gly Arg Ser Cys Leu Asp Val Pro Gly 
1               5                   10                  15      


Arg Leu Leu Pro Gln Pro Pro Pro Pro Pro Pro Pro Val Arg Arg Lys 
            20                  25                  30          


Leu Ala Leu Leu Phe Ala Met Leu Cys Val Trp Leu Tyr Met Phe Leu 
        35                  40                  45              


Tyr Ser Cys Ala Gly Ser Cys Ala Ala Ala Pro Gly Leu Leu Leu Leu 
    50                  55                  60                  


Gly Ser Gly Ser Arg Ala Ala His Asp Pro Pro Ala Leu Ala Thr Ala 
65                  70                  75                  80  


Pro Asp Gly Thr Pro Pro Arg Leu Pro Phe Arg Ala Pro Pro Ala Thr 
                85                  90                  95      


Pro Leu Ala Ser Gly Lys Glu Met Ala Glu Gly Ala Ala Ser Pro Glu 
            100                 105                 110         


Glu Gln Ser Pro Glu Val Pro Asp Ser Pro Ser Pro Ile Ser Ser Phe 
        115                 120                 125             


Phe Ser Gly Ser Gly Ser Lys Gln Leu Pro Gln Ala Ile Ile Ile Gly 
    130                 135                 140                 


Val Lys Lys Gly Gly Thr Arg Ala Leu Leu Glu Phe Leu Arg Val His 
145                 150                 155                 160 


Pro Asp Val Arg Ala Val Gly Ala Glu Pro His Phe Phe Asp Arg Ser 
                165                 170                 175     


Tyr Asp Lys Gly Leu Ala Trp Tyr Arg Asp Leu Met Pro Arg Thr Leu 
            180                 185                 190         


Asp Gly Gln Ile Thr Met Glu Lys Thr Pro Ser Tyr Phe Val Thr Arg 
        195                 200                 205             


Glu Ala Pro Ala Arg Ile Ser Ala Met Ser Lys Asp Thr Lys Leu Ile 
    210                 215                 220                 


Val Val Val Arg Asp Pro Val Thr Arg Ala Ile Ser Asp Tyr Thr Gln 
225                 230                 235                 240 


Thr Leu Ser Lys Arg Pro Asp Ile Pro Thr Phe Glu Ser Leu Thr Phe 
                245                 250                 255     


Lys Asn Arg Thr Ala Gly Leu Ile Asp Thr Ser Trp Ser Ala Ile Gln 
            260                 265                 270         


Ile Gly Ile Tyr Ala Lys His Leu Glu His Trp Leu Arg His Phe Pro 
        275                 280                 285             


Ile Arg Gln Met Leu Phe Val Ser Gly Glu Arg Leu Ile Ser Asp Pro 
    290                 295                 300                 


Ala Gly Glu Leu Gly Arg Val Gln Asp Phe Leu Gly Leu Lys Arg Ile 
305                 310                 315                 320 


Ile Thr Asp Lys His Phe Tyr Phe Asn Lys Thr Lys Gly Phe Pro Cys 
                325                 330                 335     


Leu Lys Lys Ala Glu Gly Ser Ser Arg Pro His Cys Leu Gly Lys Thr 
            340                 345                 350         


Lys Gly Arg Thr His Pro Glu Ile Asp Arg Glu Val Val Arg Arg Leu 
        355                 360                 365             


Arg Glu Phe Tyr Arg Pro Phe Asn Leu Lys Phe Tyr Gln Met Thr Gly 
    370                 375                 380                 


His Asp Phe Gly Trp Asp 
385                 390 


<210>  268
<211>  390
<212>  PRT
<213>  Homo sapiens

<400>  268

Met Gly Gln Arg Leu Ser Gly Gly Arg Ser Cys Leu Asp Val Pro Gly 
1               5                   10                  15      


Arg Leu Leu Pro Gln Pro Pro Pro Pro Pro Pro Pro Val Arg Arg Lys 
            20                  25                  30          


Leu Ala Leu Leu Phe Ala Met Leu Cys Val Trp Leu Tyr Met Phe Leu 
        35                  40                  45              


Tyr Ser Cys Ala Gly Ser Cys Ala Ala Ala Pro Gly Leu Leu Leu Leu 
    50                  55                  60                  


Gly Ser Gly Ser Arg Ala Ala His Asp Pro Pro Ala Leu Ala Thr Ala 
65                  70                  75                  80  


Pro Asp Gly Thr Pro Pro Arg Leu Pro Phe Arg Ala Pro Pro Ala Thr 
                85                  90                  95      


Pro Leu Ala Ser Gly Lys Glu Met Ala Glu Gly Ala Ala Ser Pro Glu 
            100                 105                 110         


Glu Gln Ser Pro Glu Val Pro Asp Ser Pro Ser Pro Ile Ser Ser Phe 
        115                 120                 125             


Phe Ser Gly Ser Gly Ser Lys Gln Leu Pro Gln Ala Ile Ile Ile Gly 
    130                 135                 140                 


Val Lys Lys Gly Gly Thr Arg Ala Leu Leu Glu Phe Leu Arg Val His 
145                 150                 155                 160 


Pro Asp Val Arg Ala Val Gly Ala Glu Pro His Phe Phe Asp Arg Ser 
                165                 170                 175     


Tyr Asp Lys Gly Leu Ala Trp Tyr Arg Asp Leu Met Pro Arg Thr Leu 
            180                 185                 190         


Asp Gly Gln Ile Thr Met Glu Lys Thr Pro Ser Tyr Phe Val Thr Arg 
        195                 200                 205             


Glu Ala Pro Ala Arg Ile Ser Ala Met Ser Lys Asp Thr Lys Leu Ile 
    210                 215                 220                 


Val Val Val Arg Asp Pro Val Thr Arg Ala Ile Ser Asp Tyr Thr Gln 
225                 230                 235                 240 


Thr Leu Ser Lys Arg Pro Asp Ile Pro Thr Phe Glu Ser Leu Thr Phe 
                245                 250                 255     


Lys Asn Arg Thr Ala Gly Leu Ile Asp Thr Ser Trp Ser Ala Ile Gln 
            260                 265                 270         


Ile Gly Ile Tyr Ala Lys His Leu Glu His Trp Leu Arg His Phe Pro 
        275                 280                 285             


Ile Arg Gln Met Leu Phe Val Ser Gly Glu Arg Leu Ile Ser Asp Pro 
    290                 295                 300                 


Ala Gly Glu Leu Gly Arg Val Gln Asp Phe Leu Gly Leu Lys Arg Ile 
305                 310                 315                 320 


Ile Thr Asp Lys His Phe Tyr Phe Asn Lys Thr Lys Gly Phe Pro Cys 
                325                 330                 335     


Leu Lys Lys Ala Glu Gly Ser Ser Arg Pro His Cys Leu Gly Lys Thr 
            340                 345                 350         


Lys Gly Arg Thr His Pro Glu Ile Asp Arg Glu Val Val Arg Arg Leu 
        355                 360                 365             


Arg Glu Phe Tyr Arg Pro Phe Asn Leu Lys Phe Tyr Gln Met Thr Gly 
    370                 375                 380                 


His Asp Phe Gly Trp Asp 
385                 390 


<210>  269
<211>  649
<212>  PRT
<213>  Homo sapiens

<400>  269

Met Ser Ser Phe Gly Ala Gly Lys Thr Lys Glu Val Ile Phe Ser Val 
1               5                   10                  15      


Glu Asp Gly Ser Val Lys Met Phe Leu Arg Gly Arg Pro Val Pro Met 
            20                  25                  30          


Met Ile Pro Asp Glu Leu Ala Pro Thr Tyr Ser Leu Asp Thr Arg Ser 
        35                  40                  45              


Glu Leu Pro Ser Cys Arg Leu Lys Leu Glu Trp Val Tyr Gly Tyr Arg 
    50                  55                  60                  


Gly Arg Asp Cys Arg Ala Asn Leu Tyr Leu Leu Pro Thr Gly Glu Ile 
65                  70                  75                  80  


Val Tyr Phe Val Ala Ser Val Ala Val Leu Tyr Ser Val Glu Glu Gln 
                85                  90                  95      


Arg Gln Arg His Tyr Leu Gly His Asn Asp Asp Ile Lys Cys Leu Ala 
            100                 105                 110         


Ile His Pro Asp Met Val Thr Ile Ala Thr Gly Gln Val Ala Gly Thr 
        115                 120                 125             


Thr Lys Glu Gly Lys Pro Leu Pro Pro His Val Arg Ile Trp Asp Ser 
    130                 135                 140                 


Val Ser Leu Ser Thr Leu His Val Leu Gly Leu Gly Val Phe Asp Arg 
145                 150                 155                 160 


Ala Val Cys Cys Val Gly Phe Ser Lys Ser Asn Gly Gly Asn Leu Leu 
                165                 170                 175     


Cys Ala Val Asp Glu Ser Asn Asp His Met Leu Ser Val Trp Asp Trp 
            180                 185                 190         


Ala Lys Glu Thr Lys Val Val Asp Val Lys Cys Ser Asn Glu Ala Val 
        195                 200                 205             


Leu Val Ala Thr Phe His Pro Thr Asp Pro Thr Val Leu Ile Thr Cys 
    210                 215                 220                 


Gly Lys Ser His Ile Tyr Phe Trp Thr Leu Glu Gly Gly Ser Leu Ser 
225                 230                 235                 240 


Lys Arg Gln Gly Leu Phe Glu Lys His Glu Lys Pro Lys Tyr Val Leu 
                245                 250                 255     


Cys Val Thr Phe Leu Glu Gly Gly Asp Val Val Thr Gly Asp Ser Gly 
            260                 265                 270         


Gly Asn Leu Tyr Val Trp Gly Lys Gly Gly Asn Arg Ile Thr Gln Ala 
        275                 280                 285             


Val Leu Gly Ala His Asp Gly Gly Val Phe Gly Leu Cys Ala Leu Arg 
    290                 295                 300                 


Asp Gly Thr Leu Val Ser Gly Gly Gly Arg Asp Arg Arg Val Val Leu 
305                 310                 315                 320 


Trp Gly Ser Asp Tyr Ser Lys Leu Gln Glu Val Glu Val Pro Glu Asp 
                325                 330                 335     


Phe Gly Pro Val Arg Thr Val Ala Glu Gly His Gly Asp Thr Leu Tyr 
            340                 345                 350         


Val Gly Thr Thr Arg Asn Ser Ile Leu Gln Gly Ser Val His Thr Gly 
        355                 360                 365             


Phe Ser Leu Leu Val Gln Gly His Val Glu Glu Leu Trp Gly Leu Ala 
    370                 375                 380                 


Thr His Pro Ser Arg Ala Gln Phe Val Thr Cys Gly Gln Asp Lys Leu 
385                 390                 395                 400 


Val His Leu Trp Ser Ser Asp Ser His Gln Pro Leu Trp Ser Arg Ile 
                405                 410                 415     


Ile Glu Asp Pro Ala Arg Ser Ala Gly Phe His Pro Ser Gly Ser Val 
            420                 425                 430         


Leu Ala Val Gly Thr Val Thr Gly Arg Trp Leu Leu Leu Asp Thr Glu 
        435                 440                 445             


Thr His Asp Leu Val Ala Ile His Thr Asp Gly Asn Glu Gln Ile Ser 
    450                 455                 460                 


Val Val Ser Phe Ser Pro Asp Gly Ala Tyr Leu Ala Val Gly Ser His 
465                 470                 475                 480 


Asp Asn Leu Val Tyr Val Tyr Thr Val Asp Gln Gly Gly Arg Lys Val 
                485                 490                 495     


Ser Arg Leu Gly Lys Cys Ser Gly His Ser Ser Phe Ile Thr His Leu 
            500                 505                 510         


Asp Trp Ala Gln Asp Ser Ser Cys Phe Val Thr Asn Ser Gly Asp Tyr 
        515                 520                 525             


Glu Ile Leu Tyr Trp Asp Pro Ala Thr Cys Lys Gln Ile Thr Ser Ala 
    530                 535                 540                 


Asp Ala Val Arg Asn Met Glu Trp Ala Thr Ala Thr Cys Val Leu Gly 
545                 550                 555                 560 


Phe Gly Val Phe Gly Ile Trp Ser Glu Gly Ala Asp Gly Thr Asp Ile 
                565                 570                 575     


Asn Ala Val Ala Arg Ser His Asp Gly Lys Leu Leu Ala Ser Ala Asp 
            580                 585                 590         


Asp Phe Gly Lys Val His Leu Phe Ser Tyr Pro Cys Cys Gln Pro Arg 
        595                 600                 605             


Ala Leu Ser His Lys Tyr Gly Gly His Ser Ser His Val Thr Asn Val 
    610                 615                 620                 


Ala Phe Leu Trp Asp Asp Ser Met Ala Leu Thr Thr Gly Gly Lys Asp 
625                 630                 635                 640 


Thr Ser Val Leu Gln Trp Arg Val Val 
                645                 


<210>  270
<211>  145
<212>  PRT
<213>  Homo sapiens

<400>  270

Met Ser Ser Phe Gly Ala Gly Lys Thr Lys Glu Val Ile Phe Ser Val 
1               5                   10                  15      


Ala Trp Pro Ser Thr Gln Ile Trp Ser Pro Ser Pro Arg Asp Arg Trp 
            20                  25                  30          


Arg Glu Pro Leu Arg Lys Gly Ser Arg Cys Arg Pro Thr Cys Ala Ser 
        35                  40                  45              


Gly Thr Gln Phe Pro Ser Pro Pro Tyr Thr Cys Trp Ala Trp Gly Cys 
    50                  55                  60                  


Leu Thr Glu Pro Cys Ala Val Trp Ala Ser Pro Asn Leu Met Glu Ala 
65                  70                  75                  80  


Thr Cys Cys Val Gln Trp Met Asn Pro Met Ile Thr Cys Ser Arg Cys 
                85                  90                  95      


Gly Thr Gly Pro Arg Arg Pro Arg Trp Trp Met Ser Ser Ala Pro Met 
            100                 105                 110         


Arg Leu Tyr Trp Trp Pro Pro Ser Thr Pro Arg Thr Pro Leu Cys Leu 
        115                 120                 125             


Ser Pro Ala Gly Asn Leu Thr Ser Thr Ser Gly Pro Trp Arg Gly Ala 
    130                 135                 140                 


Ala 
145 


<210>  271
<211>  76
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  271

Xaa Gly Arg Lys Val Ser Arg Leu Gly Lys Cys Ser Gly His Ser Ser 
1               5                   10                  15      


Phe Ile Thr His Leu Asp Trp Ala Gln Asp Ser Ser Cys Phe Val Thr 
            20                  25                  30          


Asn Ser Gly Asp Tyr Glu Ile Leu Tyr Leu Glu Met Gly Phe His His 
        35                  40                  45              


Leu Gly Gln Ala Gly Leu Glu Leu Leu Thr Ser Gly Asp Pro Ala Arg 
    50                  55                  60                  


Cys Cys Gly Ser Cys Cys Leu Leu Gly Leu Gln Thr 
65                  70                  75      


<210>  272
<211>  225
<212>  PRT
<213>  Homo sapiens

<400>  272

Met Phe Leu Arg Gly Arg Pro Val Pro Met Met Ile Pro Asp Glu Leu 
1               5                   10                  15      


Ala Pro Thr Tyr Ser Leu Asp Thr Arg Ser Glu Leu Pro Ser Cys Arg 
            20                  25                  30          


Leu Lys Leu Glu Trp Val Tyr Gly Tyr Arg Gly Arg Asp Cys Arg Ala 
        35                  40                  45              


Asn Leu Tyr Leu Leu Pro Thr Gly Glu Ile Val Tyr Phe Val Ala Ser 
    50                  55                  60                  


Val Ala Val Leu Tyr Ser Val Glu Glu Gln Arg Gln Arg His Tyr Leu 
65                  70                  75                  80  


Gly His Asn Asp Asp Ile Lys Cys Leu Ala Ile His Pro Asp Met Val 
                85                  90                  95      


Thr Ile Ala Thr Gly Gln Val Ala Gly Thr Thr Lys Glu Gly Lys Pro 
            100                 105                 110         


Leu Pro Pro His Val Arg Ile Trp Asp Ser Val Ser Leu Ser Thr Leu 
        115                 120                 125             


His Val Leu Gly Leu Gly Val Phe Asp Arg Ala Val Cys Cys Val Gly 
    130                 135                 140                 


Phe Ser Lys Ser Asn Gly Gly Asn Leu Leu Cys Ala Val Asp Glu Ser 
145                 150                 155                 160 


Asn Asp His Met Leu Ser Val Trp Asp Trp Ala Lys Glu Thr Lys Val 
                165                 170                 175     


Val Asp Val Lys Cys Ser Asn Glu Ala Val Leu Val Ala Thr Phe His 
            180                 185                 190         


Pro Thr Asp Pro Thr Val Leu Ile Thr Cys Gly Lys Ser His Ile Tyr 
        195                 200                 205             


Phe Trp Thr Leu Glu Gly Gly Ser Leu Ser Lys Arg Gln Gly Leu Phe 
    210                 215                 220                 


Glu 
225 


<210>  273
<211>  850
<212>  PRT
<213>  Homo sapiens

<400>  273

Met Leu Glu Arg Arg Ala Leu Leu Trp Gln Arg Glu Ala Gly Pro Gly 
1               5                   10                  15      


Trp Gly Asp Arg Ala Arg Ala Gly Thr Gly Gly Ala Gly Gly Gly Cys 
            20                  25                  30          


Gly Gly Ala Met Ala Glu Arg Gly Pro Ala Phe Cys Gly Leu Tyr Asp 
        35                  40                  45              


Thr Ser Ser Leu Leu Arg Tyr Cys Asn Asp Asp Asn Leu Ser Gly Thr 
    50                  55                  60                  


Ser Gly Met Glu Val Asp Asp Arg Val Ser Ala Leu Glu Gln Arg Leu 
65                  70                  75                  80  


Gln Leu Gln Glu Asp Glu Leu Ala Val Leu Lys Ala Ala Leu Ala Asp 
                85                  90                  95      


Ala Leu Arg Arg Leu Arg Ala Cys Glu Glu Gln Gly Ala Ala Leu Arg 
            100                 105                 110         


Ala Arg Gly Thr Pro Lys Gly Arg Ala Pro Pro Arg Leu Gly Thr Thr 
        115                 120                 125             


Ala Ser Val Cys Gln Leu Leu Lys Gly Leu Pro Thr Arg Thr Pro Leu 
    130                 135                 140                 


Asn Gly Ser Gly Pro Pro Arg Arg Val Gly Gly Tyr Ala Thr Ser Pro 
145                 150                 155                 160 


Ser Ser Pro Lys Lys Glu Ala Thr Ser Gly Arg Ser Ser Val Arg Arg 
                165                 170                 175     


Tyr Leu Ser Pro Glu Arg Leu Ala Ser Val Arg Arg Glu Asp Pro Arg 
            180                 185                 190         


Ser Arg Thr Thr Ser Ser Ser Ser Asn Cys Ser Ala Lys Lys Glu Gly 
        195                 200                 205             


Lys Thr Lys Glu Val Ile Phe Ser Val Glu Asp Gly Ser Val Lys Met 
    210                 215                 220                 


Phe Leu Arg Gly Arg Pro Val Pro Met Met Ile Pro Asp Glu Leu Ala 
225                 230                 235                 240 


Pro Thr Tyr Ser Leu Asp Thr Arg Ser Glu Leu Pro Ser Cys Arg Leu 
                245                 250                 255     


Lys Leu Glu Trp Val Tyr Gly Tyr Arg Gly Arg Asp Cys Arg Ala Asn 
            260                 265                 270         


Leu Tyr Leu Leu Pro Thr Gly Glu Ile Val Tyr Phe Val Ala Ser Val 
        275                 280                 285             


Ala Val Leu Tyr Ser Val Glu Glu Gln Arg Gln Arg His Tyr Leu Gly 
    290                 295                 300                 


His Asn Asp Asp Ile Lys Cys Leu Ala Ile His Pro Asp Met Val Thr 
305                 310                 315                 320 


Ile Ala Thr Gly Gln Val Ala Gly Thr Thr Lys Glu Gly Lys Pro Leu 
                325                 330                 335     


Pro Pro His Val Arg Ile Trp Asp Ser Val Ser Leu Ser Thr Leu His 
            340                 345                 350         


Val Leu Gly Leu Gly Val Phe Asp Arg Ala Val Cys Cys Val Gly Phe 
        355                 360                 365             


Ser Lys Ser Asn Gly Gly Asn Leu Leu Cys Ala Val Asp Glu Ser Asn 
    370                 375                 380                 


Asp His Met Leu Ser Val Trp Asp Trp Ala Lys Glu Thr Lys Val Val 
385                 390                 395                 400 


Asp Val Lys Cys Ser Asn Glu Ala Val Leu Val Ala Thr Phe His Pro 
                405                 410                 415     


Thr Asp Pro Thr Val Leu Ile Thr Cys Gly Lys Ser His Ile Tyr Phe 
            420                 425                 430         


Trp Thr Leu Glu Gly Gly Ser Leu Ser Lys Arg Gln Gly Leu Phe Glu 
        435                 440                 445             


Lys His Glu Lys Pro Lys Tyr Val Leu Cys Val Thr Phe Leu Glu Gly 
    450                 455                 460                 


Gly Asp Val Val Thr Gly Asp Ser Gly Gly Asn Leu Tyr Val Trp Gly 
465                 470                 475                 480 


Lys Gly Gly Asn Arg Ile Thr Gln Ala Val Leu Gly Ala His Asp Gly 
                485                 490                 495     


Gly Val Phe Gly Leu Cys Ala Leu Arg Asp Gly Thr Leu Val Ser Gly 
            500                 505                 510         


Gly Gly Arg Asp Arg Arg Val Val Leu Trp Gly Ser Asp Tyr Ser Lys 
        515                 520                 525             


Leu Gln Glu Val Glu Val Pro Glu Asp Phe Gly Pro Val Arg Thr Val 
    530                 535                 540                 


Ala Glu Gly His Gly Asp Thr Leu Tyr Val Gly Thr Thr Arg Asn Ser 
545                 550                 555                 560 


Ile Leu Gln Gly Ser Val His Thr Gly Phe Ser Leu Leu Val Gln Gly 
                565                 570                 575     


His Val Glu Glu Leu Trp Gly Leu Ala Thr His Pro Ser Arg Ala Gln 
            580                 585                 590         


Phe Val Thr Cys Gly Gln Asp Lys Leu Val His Leu Trp Ser Ser Asp 
        595                 600                 605             


Ser His Gln Pro Leu Trp Ser Arg Ile Ile Glu Asp Pro Ala Arg Ser 
    610                 615                 620                 


Ala Gly Phe His Pro Ser Gly Ser Val Leu Ala Val Gly Thr Val Thr 
625                 630                 635                 640 


Gly Arg Trp Leu Leu Leu Asp Thr Glu Thr His Asp Leu Val Ala Ile 
                645                 650                 655     


His Thr Asp Gly Asn Glu Gln Ile Ser Val Val Ser Phe Ser Pro Asp 
            660                 665                 670         


Gly Ala Tyr Leu Ala Val Gly Ser His Asp Asn Leu Val Tyr Val Tyr 
        675                 680                 685             


Thr Val Asp Gln Gly Gly Arg Lys Val Ser Arg Leu Gly Lys Cys Ser 
    690                 695                 700                 


Gly His Ser Ser Phe Ile Thr His Leu Asp Trp Ala Gln Asp Ser Ser 
705                 710                 715                 720 


Cys Phe Val Thr Asn Ser Gly Asp Tyr Glu Ile Leu Tyr Trp Asp Pro 
                725                 730                 735     


Ala Thr Cys Lys Gln Ile Thr Ser Ala Asp Ala Val Arg Asn Met Glu 
            740                 745                 750         


Trp Ala Thr Ala Thr Cys Val Leu Gly Phe Gly Val Phe Gly Ile Trp 
        755                 760                 765             


Ser Glu Gly Ala Asp Gly Thr Asp Ile Asn Ala Val Ala Arg Ser His 
    770                 775                 780                 


Asp Gly Lys Leu Leu Ala Ser Ala Asp Asp Phe Gly Lys Val His Leu 
785                 790                 795                 800 


Phe Ser Tyr Pro Cys Cys Gln Pro Arg Ala Leu Ser His Lys Tyr Gly 
                805                 810                 815     


Gly His Ser Ser His Val Thr Asn Val Ala Phe Leu Trp Asp Asp Ser 
            820                 825                 830         


Met Ala Leu Thr Thr Gly Gly Lys Asp Thr Ser Val Leu Gln Trp Arg 
        835                 840                 845             


Val Val 
    850 


<210>  274
<211>  73
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  274

Xaa His Gln Pro Leu Trp Ser Arg Ile Ile Glu Asp Pro Ala Arg Ser 
1               5                   10                  15      


Ala Gly Phe His Pro Ser Gly Ser Val Leu Ala Val Gly Thr Val Thr 
            20                  25                  30          


Gly Arg Trp Leu Leu Leu Asp Thr Glu Thr His Asp Leu Val Ala Ile 
        35                  40                  45              


His Thr Asp Gly Asn Glu Gln Ile Ser Val Val Ser Phe Ser Pro Gly 
    50                  55                  60                  


Pro Phe Gln Phe Tyr His Pro Pro Gly 
65                  70              


<210>  275
<211>  121
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  275

Xaa Leu Cys Ala Val Asp Glu Ser Asn Asp His Met Leu Ser Val Trp 
1               5                   10                  15      


Asp Trp Ala Lys Glu Thr Lys Val Val Asp Val Lys Val Pro Glu Asp 
            20                  25                  30          


Phe Gly Pro Val Arg Thr Val Ala Glu Gly His Gly Asp Thr Leu Tyr 
        35                  40                  45              


Val Gly Thr Thr Arg Asn Ser Ile Leu Gln Gly Ser Val His Thr Gly 
    50                  55                  60                  


Phe Ser Leu Leu Val Gln Gly His Val Glu Glu Leu Trp Gly Leu Ala 
65                  70                  75                  80  


Thr His Pro Ser Arg Ala Gln Phe Val Thr Cys Gly Gln Asp Lys Leu 
                85                  90                  95      


Val His Leu Trp Ser Ser Asp Ser His Gln Pro Leu Trp Ser Arg Ile 
            100                 105                 110         


Ile Glu Asp Pro Ala Arg Ser Ala Gly 
        115                 120     


<210>  276
<211>  427
<212>  PRT
<213>  Homo sapiens

<400>  276

Met Ser Ser Phe Gly Ala Gly Lys Thr Lys Glu Val Ile Phe Ser Val 
1               5                   10                  15      


Glu Asp Gly Ser Val Lys Met Phe Leu Arg Gly Arg Pro Val Pro Met 
            20                  25                  30          


Met Ile Pro Asp Glu Leu Ala Pro Thr Tyr Ser Leu Asp Thr Arg Ser 
        35                  40                  45              


Glu Leu Pro Ser Cys Arg Leu Lys Leu Glu Trp Val Tyr Gly Tyr Arg 
    50                  55                  60                  


Gly Arg Asp Cys Arg Ala Asn Leu Tyr Leu Leu Pro Thr Gly Glu Ile 
65                  70                  75                  80  


Val Tyr Phe Val Ala Ser Val Ala Val Leu Tyr Ser Val Glu Glu Gln 
                85                  90                  95      


Arg Gln Arg His Tyr Leu Gly His Asn Asp Asp Ile Lys Cys Leu Ala 
            100                 105                 110         


Ile His Pro Asp Met Val Thr Ile Ala Thr Gly Gln Val Ala Gly Thr 
        115                 120                 125             


Thr Lys Glu Gly Lys Pro Leu Pro Pro His Val Arg Ile Trp Asp Ser 
    130                 135                 140                 


Val Ser Leu Ser Thr Leu His Val Leu Gly Leu Gly Val Phe Asp Arg 
145                 150                 155                 160 


Ala Val Cys Cys Val Gly Phe Ser Lys Ser Asn Gly Gly Asn Leu Leu 
                165                 170                 175     


Cys Ala Val Asp Glu Ser Asn Asp His Met Leu Ser Val Trp Asp Trp 
            180                 185                 190         


Ala Lys Glu Thr Lys Val Val Asp Val Lys Cys Ser Asn Glu Ala Val 
        195                 200                 205             


Leu Val Ala Thr Phe His Pro Thr Asp Pro Thr Val Leu Ile Thr Cys 
    210                 215                 220                 


Gly Lys Ser His Ile Tyr Phe Trp Thr Leu Glu Gly Gly Ser Leu Ser 
225                 230                 235                 240 


Lys Arg Gln Gly Leu Phe Glu Lys His Glu Lys Pro Lys Tyr Val Leu 
                245                 250                 255     


Cys Val Thr Phe Leu Glu Gly Gly Asp Val Val Thr Gly Asp Ser Gly 
            260                 265                 270         


Gly Asn Leu Tyr Val Trp Gly Lys Gly Gly Asn Arg Ile Thr Gln Ala 
        275                 280                 285             


Val Leu Gly Ala His Asp Gly Gly Val Phe Gly Leu Cys Ala Leu Arg 
    290                 295                 300                 


Asp Gly Thr Leu Val Ser Gly Gly Gly Arg Asp Arg Arg Val Val Leu 
305                 310                 315                 320 


Trp Gly Ser Asp Tyr Ser Lys Leu Gln Glu Val Glu Val Pro Glu Asp 
                325                 330                 335     


Phe Gly Pro Val Arg Thr Val Ala Glu Gly His Gly Asp Thr Leu Tyr 
            340                 345                 350         


Val Gly Thr Thr Arg Asn Ser Ile Leu Gln Gly Ser Val His Thr Gly 
        355                 360                 365             


Phe Ser Leu Leu Val Gln Gly His Val Glu Glu Leu Trp Gly Leu Ala 
    370                 375                 380                 


Thr His Pro Ser Arg Ala Gln Phe Val Thr Cys Gly Gln Asp Lys Leu 
385                 390                 395                 400 


Val His Leu Trp Ser Ser Asp Ser His Gln Pro Leu Trp Ser Arg Ile 
                405                 410                 415     


Ile Glu Met Ala Ala Ala Gly His Gly Asp Pro 
            420                 425         


<210>  277
<211>  773
<212>  PRT
<213>  Homo sapiens

<400>  277

Met Ser Ser Phe Gly Ala Gly Lys Thr Lys Glu Val Ile Phe Ser Val 
1               5                   10                  15      


Glu Asp Gly Ser Val Lys Met Phe Leu Arg Gly Arg Pro Val Pro Met 
            20                  25                  30          


Met Ile Pro Asp Glu Leu Ala Pro Thr Tyr Ser Leu Asp Thr Arg Ser 
        35                  40                  45              


Glu Leu Pro Ser Cys Arg Leu Lys Leu Glu Trp Val Tyr Gly Tyr Arg 
    50                  55                  60                  


Gly Arg Asp Cys Arg Ala Asn Leu Tyr Leu Leu Pro Thr Gly Glu Ile 
65                  70                  75                  80  


Val Tyr Phe Val Ala Ser Val Ala Val Leu Tyr Ser Val Glu Glu Gln 
                85                  90                  95      


Arg Gln Arg His Tyr Leu Gly His Asn Asp Asp Ile Lys Cys Leu Ala 
            100                 105                 110         


Ile His Pro Asp Met Val Thr Ile Ala Thr Gly Gln Val Ala Gly Thr 
        115                 120                 125             


Thr Lys Glu Gly Lys Pro Leu Pro Pro His Val Arg Ile Trp Asp Ser 
    130                 135                 140                 


Val Ser Leu Ser Thr Leu His Val Leu Gly Leu Gly Val Phe Asp Arg 
145                 150                 155                 160 


Ala Val Cys Cys Val Gly Phe Ser Lys Ser Asn Gly Gly Asn Leu Leu 
                165                 170                 175     


Cys Ala Val Asp Glu Ser Asn Asp His Met Leu Ser Val Trp Asp Trp 
            180                 185                 190         


Ala Lys Glu Thr Lys Val Val Asp Val Lys Cys Ser Asn Glu Ala Val 
        195                 200                 205             


Leu Val Ala Thr Phe His Pro Thr Asp Pro Thr Val Leu Ile Thr Cys 
    210                 215                 220                 


Gly Lys Ser His Ile Tyr Phe Trp Thr Leu Glu Gly Gly Ser Leu Ser 
225                 230                 235                 240 


Lys Arg Gln Gly Leu Phe Glu Lys His Glu Lys Pro Lys Tyr Val Leu 
                245                 250                 255     


Cys Val Thr Phe Leu Glu Gly Gly Asp Val Val Thr Gly Asp Ser Gly 
            260                 265                 270         


Gly Asn Leu Tyr Val Trp Gly Lys Gly Gly Asn Arg Ile Thr Gln Ala 
        275                 280                 285             


Val Leu Gly Ala His Asp Gly Gly Val Phe Gly Leu Cys Ala Leu Arg 
    290                 295                 300                 


Asp Gly Thr Leu Val Ser Gly Gly Gly Arg Asp Arg Arg Val Val Leu 
305                 310                 315                 320 


Trp Gly Ser Asp Tyr Ser Lys Leu Gln Glu Val Glu Val Pro Glu Asp 
                325                 330                 335     


Phe Gly Pro Val Arg Thr Val Ala Glu Gly His Gly Asp Thr Leu Tyr 
            340                 345                 350         


Val Gly Thr Thr Arg Asn Ser Ile Leu Gln Gly Ser Val His Thr Gly 
        355                 360                 365             


Phe Ser Leu Leu Val Gln Gly His Val Glu Glu Leu Trp Gly Leu Ala 
    370                 375                 380                 


Thr His Pro Ser Arg Ala Gln Phe Val Thr Cys Gly Gln Asp Lys Leu 
385                 390                 395                 400 


Val His Leu Trp Ser Ser Asp Ser His Gln Pro Leu Trp Ser Arg Ile 
                405                 410                 415     


Ile Glu Asp Pro Ala Arg Ser Ala Gly Phe His Pro Ser Gly Ser Val 
            420                 425                 430         


Leu Ala Val Gly Thr Val Thr Gly Arg Trp Leu Leu Leu Asp Thr Glu 
        435                 440                 445             


Thr His Asp Leu Val Ala Ile His Thr Asp Gly Asn Glu Gln Ile Ser 
    450                 455                 460                 


Val Val Ser Phe Ser Pro Asp Gly Ala Tyr Leu Ala Val Gly Ser His 
465                 470                 475                 480 


Asp Asn Leu Val Tyr Val Tyr Thr Val Asp Gln Gly Gly Arg Lys Val 
                485                 490                 495     


Ser Arg Leu Gly Lys Cys Ser Gly His Ser Ser Phe Ile Thr His Leu 
            500                 505                 510         


Asp Trp Ala Gln Asp Ser Ser Cys Phe Val Thr Asn Ser Gly Asp Tyr 
        515                 520                 525             


Glu Ile Leu Tyr Trp Asp Pro Ala Thr Cys Lys Gln Ile Thr Ser Ala 
    530                 535                 540                 


Asp Ala Val Arg Asn Met Glu Trp Ala Thr Ala Thr Cys Val Leu Gly 
545                 550                 555                 560 


Phe Gly Val Phe Gly Ile Trp Ser Glu Gly Ala Asp Gly Thr Asp Ile 
                565                 570                 575     


Asn Ala Val Ala Arg Ser His Asp Gly Lys Leu Leu Ala Ser Ala Asp 
            580                 585                 590         


Asp Phe Gly Lys Val His Leu Phe Ser Tyr Pro Cys Cys Gln Pro Arg 
        595                 600                 605             


Val Leu Gly Lys Trp Pro Ser Ala Ala Glu Ala Ala Leu Ser Ser Gly 
    610                 615                 620                 


Ile Arg Val Leu Phe Arg Pro Leu Val Ala Ser Leu Gly Pro Ala Trp 
625                 630                 635                 640 


Lys Asn Val Pro Arg Lys Phe Cys Trp Lys Ser Ala Gly Asp Ser Pro 
                645                 650                 655     


Arg Asp Pro Pro Pro Arg Pro Gln Gly His Ser Gln Pro Ser Phe Pro 
            660                 665                 670         


Ser Ser Gly Pro Trp Glu Thr Ala Val Cys Lys Phe Tyr Arg Gln Gly 
        675                 680                 685             


Arg Trp Arg Glu Val Arg Val Phe Ala Ser Trp Ala Pro Pro Cys Ile 
    690                 695                 700                 


Pro His Ser Gln Trp Leu Trp Phe Pro Ser Ser Glu Pro Gln Phe Leu 
705                 710                 715                 720 


Trp Glu Leu Glu Leu Ser Leu Glu Thr Gly Asn Arg Leu Pro Pro Cys 
                725                 730                 735     


Pro Phe Cys Pro Arg Leu Ala Met Ala Ser Cys Pro Leu Arg Met Val 
            740                 745                 750         


Pro Trp Gly Arg Pro Ile Leu Cys Gly Phe Leu His Ser Ala His Pro 
        755                 760                 765             


Ser Ile Asn Cys Pro 
    770             


<210>  278
<211>  98
<212>  PRT
<213>  Homo sapiens

<400>  278

Met Phe Leu Arg Gly Arg Pro Val Pro Met Met Ile Pro Asp Glu Leu 
1               5                   10                  15      


Ala Pro Thr Tyr Ser Leu Asp Thr Arg Ser Glu Leu Pro Ser Cys Arg 
            20                  25                  30          


Leu Lys Leu Glu Trp Val Tyr Gly Tyr Arg Gly Arg Asp Cys Arg Ala 
        35                  40                  45              


Asn Leu Tyr Leu Leu Pro Thr Gly Glu Ile Val Tyr Phe Val Ala Ser 
    50                  55                  60                  


Val Ala Val Leu Tyr Ser Val Glu Glu Gln Arg Gln Arg His Tyr Leu 
65                  70                  75                  80  


Gly His Asn Asp Asp Ile Lys Cys Leu Ala Ile His Pro Asp Met Val 
                85                  90                  95      


Thr Ile 
        


<210>  279
<211>  111
<212>  PRT
<213>  Homo sapiens

<400>  279

Met Phe Leu Arg Gly Arg Pro Val Pro Met Met Ile Pro Asp Glu Leu 
1               5                   10                  15      


Ala Pro Thr Tyr Ser Leu Asp Thr Arg Ser Glu Leu Pro Ser Cys Arg 
            20                  25                  30          


Leu Lys Leu Glu Trp Val Tyr Gly Tyr Arg Gly Arg Asp Cys Arg Ala 
        35                  40                  45              


Asn Leu Tyr Leu Leu Pro Thr Gly Glu Ile Val Tyr Phe Val Ala Ser 
    50                  55                  60                  


Val Ala Val Leu Tyr Ser Val Glu Glu Gln Arg Gln Arg His Tyr Leu 
65                  70                  75                  80  


Gly His Asn Asp Asp Ile Lys Cys Leu Ala Ile His Pro Asp Met Val 
                85                  90                  95      


Thr Ile Ala Thr Gly Gln Val Ala Gly Thr Thr Lys Glu Gly Lys 
            100                 105                 110     


<210>  280
<211>  51
<212>  PRT
<213>  Homo sapiens

<400>  280

Trp Thr Leu Glu Gly Gly Ser Leu Ser Lys Arg Gln Gly Leu Phe Glu 
1               5                   10                  15      


Lys His Glu Lys Pro Lys Tyr Val Leu Cys Val Thr Phe Leu Glu Gly 
            20                  25                  30          


Gly Asp Val Val Thr Gly Asp Ser Gly Gly Asn Leu Tyr Val Trp Gly 
        35                  40                  45              


Lys Gly Pro 
    50      


<210>  281
<211>  148
<212>  PRT
<213>  Homo sapiens

<400>  281

Met Phe Leu Arg Gly Arg Pro Val Pro Met Met Ile Pro Asp Glu Leu 
1               5                   10                  15      


Ala Pro Thr Tyr Ser Leu Asp Thr Arg Ser Glu Leu Pro Ser Cys Arg 
            20                  25                  30          


Leu Lys Leu Glu Trp Val Tyr Gly Tyr Arg Gly Arg Asp Cys Arg Ala 
        35                  40                  45              


Asn Leu Tyr Leu Leu Pro Thr Gly Glu Ile Val Tyr Phe Val Ala Ser 
    50                  55                  60                  


Val Ala Val Leu Tyr Ser Val Glu Glu Gln Arg Gln Arg His Tyr Leu 
65                  70                  75                  80  


Gly His Asn Asp Asp Ile Lys Cys Leu Ala Ile His Pro Asp Met Val 
                85                  90                  95      


Thr Ile Ala Thr Gly Gln Val Ala Gly Thr Thr Lys Glu Gly Lys Pro 
            100                 105                 110         


Leu Pro Pro His Val Arg Ile Trp Asp Ser Val Ser Leu Ser Thr Leu 
        115                 120                 125             


His Val Leu Gly Leu Gly Val Phe Asp Arg Ala Val Cys Cys Val Gly 
    130                 135                 140                 


Phe Ser Lys Ser 
145             


<210>  282
<211>  91
<212>  PRT
<213>  Homo sapiens

<400>  282

Pro Leu Pro Pro His Val Arg Ile Trp Asp Ser Val Ser Leu Ser Thr 
1               5                   10                  15      


Leu His Val Leu Gly Leu Gly Val Phe Asp Arg Ala Val Cys Cys Val 
            20                  25                  30          


Gly Phe Ser Lys Ser Asn Gly Gly Asn Leu Leu Cys Ala Val Asp Glu 
        35                  40                  45              


Ser Asn Asp His Met Leu Ser Val Trp Asp Trp Ala Lys Glu Thr Lys 
    50                  55                  60                  


Val Val Asp Val Lys Ala Gly Val Gln Trp His Asn Leu Gly Ser Leu 
65                  70                  75                  80  


Gln Pro Pro Pro Pro Arg Phe Gln Arg Phe Ser 
                85                  90      


<210>  283
<211>  133
<212>  PRT
<213>  Homo sapiens

<400>  283

Met Phe Leu Arg Gly Arg Pro Val Pro Met Met Ile Pro Asp Glu Leu 
1               5                   10                  15      


Ala Pro Thr Tyr Ser Leu Asp Thr Arg Ser Glu Leu Pro Ser Cys Arg 
            20                  25                  30          


Leu Lys Leu Glu Trp Val Tyr Gly Tyr Arg Gly Arg Asp Cys Arg Ala 
        35                  40                  45              


Asn Leu Tyr Leu Leu Pro Thr Gly Glu Ile Val Tyr Phe Val Ala Ser 
    50                  55                  60                  


Val Ala Val Leu Tyr Ser Val Glu Glu Gln Arg Gln Arg His Tyr Leu 
65                  70                  75                  80  


Gly His Asn Asp Asp Ile Lys Cys Leu Ala Ile His Pro Asp Met Val 
                85                  90                  95      


Thr Ile Ala Thr Gly Gln Val Ala Gly Thr Thr Lys Glu Gly Lys Pro 
            100                 105                 110         


Leu Pro Pro His Val Arg Ile Trp Asp Ser Val Ser Leu Ser Thr Leu 
        115                 120                 125             


His Val Leu Gly Leu 
    130             


<210>  284
<211>  252
<212>  PRT
<213>  Homo sapiens

<400>  284

Met Lys Met Lys Leu Phe Gln Thr Ile Cys Arg Gln Leu Arg Ser Ser 
1               5                   10                  15      


Lys Phe Ser Val Glu Ser Ala Ala Leu Val Ala Phe Ser Thr Ser Ser 
            20                  25                  30          


Tyr Ser Cys Gly Arg Lys Lys Lys Val Asn Pro Tyr Glu Glu Val Asp 
        35                  40                  45              


Gln Glu Lys Tyr Ser Asn Leu Val Gln Ser Val Leu Ser Ser Arg Gly 
    50                  55                  60                  


Val Ala Gln Thr Pro Gly Ser Val Glu Glu Asp Ala Leu Leu Cys Gly 
65                  70                  75                  80  


Pro Val Ser Lys His Lys Leu Pro Asn Gln Gly Glu Asp Arg Arg Val 
                85                  90                  95      


Pro Gln Asn Trp Phe Pro Ile Phe Asn Pro Glu Arg Ser Asp Lys Pro 
            100                 105                 110         


Asn Ala Ser Asp Pro Ser Val Pro Leu Lys Ile Pro Leu Gln Arg Asn 
        115                 120                 125             


Val Ile Pro Ser Val Thr Arg Val Leu Gln Gln Thr Met Thr Lys Gln 
    130                 135                 140                 


Gln Val Phe Leu Leu Glu Arg Trp Lys Gln Arg Met Ile Leu Glu Leu 
145                 150                 155                 160 


Gly Glu Asp Gly Phe Lys Glu Tyr Thr Ser Ser Ser Met Trp Leu Asn 
                165                 170                 175     


Cys Gly Gly Leu Gln Arg Trp Ile Thr Cys Pro Pro Thr Phe His Gly 
            180                 185                 190         


Cys Arg Ala Leu Phe Pro Val Leu Asp Gln Val Ala Ser Ser Thr Arg 
        195                 200                 205             


Arg Ile Tyr Gly Lys Glu Lys Glu Pro Glu Tyr Ser Glu Thr Arg Ile 
    210                 215                 220                 


Phe Arg Ile Gly Ser Lys Leu Leu Phe Gly Asn Ile Gln His Leu Leu 
225                 230                 235                 240 


Thr Val Trp Glu His Ile Leu Leu Phe Thr Pro Val 
                245                 250         


<210>  285
<211>  264
<212>  PRT
<213>  Homo sapiens

<400>  285

Met Lys Met Lys Leu Phe Gln Thr Ile Cys Arg Gln Leu Arg Ser Ser 
1               5                   10                  15      


Lys Phe Ser Val Glu Ser Ala Ala Leu Val Ala Phe Ser Thr Ser Ser 
            20                  25                  30          


Tyr Ser Cys Gly Arg Lys Lys Lys Val Asn Pro Tyr Glu Glu Val Asp 
        35                  40                  45              


Gln Glu Lys Tyr Ser Asn Leu Val Gln Ser Val Leu Ser Ser Arg Gly 
    50                  55                  60                  


Val Ala Gln Thr Pro Gly Ser Val Glu Glu Asp Ala Leu Leu Cys Gly 
65                  70                  75                  80  


Pro Val Ser Lys His Lys Leu Pro Asn Gln Asp Val Phe Leu Gln Gly 
                85                  90                  95      


Lys Arg Phe His Glu Ala Leu Glu Ser Ile Leu Ser Pro Gln Glu Thr 
            100                 105                 110         


Leu Lys Glu Arg Asp Glu Asn Leu Leu Lys Ser Gly Tyr Ile Glu Ser 
        115                 120                 125             


Val Gln His Ile Leu Lys Asp Val Ser Gly Val Arg Ala Leu Glu Ser 
    130                 135                 140                 


Ala Val Gln His Glu Thr Leu Asn Tyr Ile Gly Leu Leu Asp Cys Val 
145                 150                 155                 160 


Ala Glu Tyr Gln Gly Lys Leu Cys Val Ile Asp Trp Lys Thr Ser Glu 
                165                 170                 175     


Lys Pro Lys Pro Phe Ile Gln Ser Thr Phe Asp Asn Pro Leu Gln Val 
            180                 185                 190         


Val Ala Tyr Met Gly Ala Met Asn His Asp Thr Asn Tyr Ser Phe Gln 
        195                 200                 205             


Val Gln Cys Gly Leu Ile Val Val Ala Tyr Lys Asp Gly Ser Pro Ala 
    210                 215                 220                 


His Pro His Phe Met Asp Ala Glu Leu Cys Ser Gln Tyr Trp Thr Lys 
225                 230                 235                 240 


Trp Leu Leu Arg Leu Glu Glu Tyr Thr Glu Lys Lys Lys Asn Gln Asn 
                245                 250                 255     


Ile Gln Lys Pro Glu Tyr Ser Glu 
            260                 


<210>  286
<211>  344
<212>  PRT
<213>  Homo sapiens

<400>  286

Met Lys Met Lys Leu Phe Gln Thr Ile Cys Arg Gln Leu Arg Ser Ser 
1               5                   10                  15      


Lys Phe Ser Val Glu Ser Ala Ala Leu Val Ala Phe Ser Thr Ser Ser 
            20                  25                  30          


Tyr Ser Cys Gly Arg Lys Lys Lys Val Asn Pro Tyr Glu Glu Val Asp 
        35                  40                  45              


Gln Glu Lys Tyr Ser Asn Leu Val Gln Ser Val Leu Ser Ser Arg Gly 
    50                  55                  60                  


Val Ala Gln Thr Pro Gly Ser Val Glu Glu Asp Ala Leu Leu Cys Gly 
65                  70                  75                  80  


Pro Val Ser Lys His Lys Leu Pro Asn Gln Gly Glu Asp Arg Arg Val 
                85                  90                  95      


Pro Gln Asn Trp Phe Pro Ile Phe Asn Pro Glu Arg Ser Asp Lys Pro 
            100                 105                 110         


Asn Ala Ser Asp Pro Ser Val Pro Leu Lys Ile Pro Leu Gln Arg Asn 
        115                 120                 125             


Val Ile Pro Ser Val Thr Arg Val Leu Gln Gln Thr Met Thr Lys Gln 
    130                 135                 140                 


Gln Val Phe Leu Leu Glu Arg Trp Lys Gln Arg Met Ile Leu Glu Leu 
145                 150                 155                 160 


Gly Glu Asp Gly Phe Lys Glu Tyr Thr Ser Asn Val Phe Leu Gln Gly 
                165                 170                 175     


Lys Arg Phe His Glu Ala Leu Glu Ser Ile Leu Ser Pro Gln Glu Thr 
            180                 185                 190         


Leu Lys Glu Arg Asp Glu Asn Leu Leu Lys Ser Gly Tyr Ile Glu Ser 
        195                 200                 205             


Val Gln His Ile Leu Lys Asp Val Ser Gly Val Arg Ala Leu Glu Ser 
    210                 215                 220                 


Ala Val Gln His Glu Thr Leu Asn Tyr Ile Gly Leu Leu Asp Cys Val 
225                 230                 235                 240 


Ala Glu Tyr Gln Gly Lys Leu Cys Val Ile Asp Trp Lys Thr Ser Glu 
                245                 250                 255     


Lys Pro Lys Pro Phe Ile Gln Ser Thr Phe Asp Asn Pro Leu Gln Val 
            260                 265                 270         


Val Ala Tyr Met Gly Ala Met Asn His Asp Thr Asn Tyr Ser Phe Gln 
        275                 280                 285             


Val Gln Cys Gly Leu Ile Val Val Ala Tyr Lys Asp Gly Ser Pro Ala 
    290                 295                 300                 


His Pro His Phe Met Asp Ala Glu Leu Cys Ser Gln Tyr Trp Thr Lys 
305                 310                 315                 320 


Trp Leu Leu Arg Leu Glu Glu Tyr Thr Glu Lys Lys Lys Asn Gln Asn 
                325                 330                 335     


Ile Gln Lys Pro Glu Tyr Ser Glu 
            340                 


<210>  287
<211>  355
<212>  PRT
<213>  Homo sapiens

<400>  287

Met Gly Pro Gly Arg Cys Leu Leu Thr Ala Leu Leu Leu Leu Ala Leu 
1               5                   10                  15      


Ala Pro Pro Pro Glu Ala Ser Gln Tyr Cys Gly Arg Leu Glu Tyr Trp 
            20                  25                  30          


Asn Pro Asp Asn Lys Cys Cys Ser Ser Cys Leu Gln Arg Phe Gly Pro 
        35                  40                  45              


Pro Pro Cys Pro Asp Tyr Glu Phe Arg Glu Asn Cys Gly Leu Asn Asp 
    50                  55                  60                  


His Gly Asp Phe Val Thr Pro Pro Phe Arg Lys Cys Ser Ser Gly Gln 
65                  70                  75                  80  


Cys Asn Pro Asp Gly Ala Glu Leu Cys Ser Pro Cys Gly Gly Gly Ala 
                85                  90                  95      


Val Thr Pro Thr Pro Ala Ala Gly Gly Gly Arg Thr Pro Trp Arg Cys 
            100                 105                 110         


Arg Glu Arg Pro Val Pro Ala Lys Gly His Cys Pro Leu Thr Pro Gly 
        115                 120                 125             


Asn Pro Gly Ala Pro Ser Ser Gln Glu Arg Ser Ser Pro Ala Ser Ser 
    130                 135                 140                 


Ile Ala Trp Arg Thr Pro Glu Pro Val Pro Gln Gln Ala Trp Pro Asn 
145                 150                 155                 160 


Phe Leu Pro Leu Val Val Leu Val Leu Leu Leu Thr Leu Ala Val Ile 
                165                 170                 175     


Ala Ile Leu Leu Phe Ile Leu Leu Trp His Leu Cys Trp Pro Lys Glu 
            180                 185                 190         


Lys Ala Asp Pro Tyr Pro Tyr Pro Gly Leu Val Cys Gly Val Pro Asn 
        195                 200                 205             


Thr His Thr Pro Ser Ser Ser His Leu Ser Ser Pro Gly Ala Leu Glu 
    210                 215                 220                 


Thr Gly Asp Thr Trp Lys Glu Ala Ser Leu Leu Pro Leu Leu Ser Arg 
225                 230                 235                 240 


Glu Leu Ser Ser Leu Ala Ser Gln Pro Leu Ser Arg Leu Leu Asp Glu 
                245                 250                 255     


Leu Glu Val Leu Glu Glu Leu Ile Val Leu Leu Asp Pro Glu Pro Gly 
            260                 265                 270         


Pro Gly Gly Gly Met Ala His Gly Thr Thr Arg His Leu Ala Ala Arg 
        275                 280                 285             


Tyr Gly Leu Pro Ala Ala Trp Ser Thr Phe Ala Tyr Ser Leu Arg Pro 
    290                 295                 300                 


Ser Arg Ser Pro Leu Arg Ala Leu Ile Glu Met Val Val Ala Arg Glu 
305                 310                 315                 320 


Pro Ser Ala Ser Leu Gly Gln Leu Gly Thr His Leu Ala Gln Leu Gly 
                325                 330                 335     


Arg Ala Asp Ala Leu Arg Val Leu Ser Lys Leu Gly Ser Ser Gly Val 
            340                 345                 350         


Cys Trp Ala 
        355 


<210>  288
<211>  132
<212>  PRT
<213>  Homo sapiens

<400>  288

Met Gly Pro Gly Arg Cys Leu Leu Thr Ala Leu Leu Leu Leu Ala Leu 
1               5                   10                  15      


Ala Pro Pro Pro Glu Ala Ser Gln Tyr Cys Gly Arg Leu Glu Tyr Trp 
            20                  25                  30          


Asn Pro Asp Asn Lys Cys Cys Ser Ser Cys Leu Gln Arg Phe Gly Pro 
        35                  40                  45              


Pro Pro Cys Pro Asp Tyr Glu Phe Arg Glu Asn Cys Gly Leu Asn Asp 
    50                  55                  60                  


His Gly Asp Phe Val Thr Pro Pro Phe Arg Lys Cys Ser Ser Gly Gln 
65                  70                  75                  80  


Cys Asn Pro Asp Gly Ala Glu Leu Cys Ser Pro Cys Gly Gly Gly Ala 
                85                  90                  95      


Val Thr Pro Thr Pro Ala Ala Gly Gly Gly Arg Thr Pro Trp Arg Cys 
            100                 105                 110         


Arg Glu Ala Gly Pro Cys Gln Gly Ala Leu Pro Pro His Thr Trp Lys 
        115                 120                 125             


Pro Arg Arg Pro 
    130         


<210>  289
<211>  187
<212>  PRT
<213>  Homo sapiens

<400>  289

Met Gly Pro Gly Arg Cys Leu Leu Thr Ala Leu Leu Leu Leu Ala Leu 
1               5                   10                  15      


Ala Pro Pro Pro Glu Ala Ser Gln Tyr Cys Gly Arg Leu Glu Tyr Trp 
            20                  25                  30          


Asn Pro Asp Asn Lys Cys Cys Ser Ser Cys Leu Gln Arg Phe Gly Pro 
        35                  40                  45              


Pro Pro Cys Pro Gly Ala Leu Glu Thr Gly Asp Thr Trp Lys Glu Ala 
    50                  55                  60                  


Ser Leu Leu Pro Leu Leu Ser Arg Glu Leu Ser Ser Leu Ala Ser Gln 
65                  70                  75                  80  


Pro Leu Ser Arg Leu Leu Asp Glu Leu Glu Val Leu Glu Glu Leu Ile 
                85                  90                  95      


Val Leu Leu Asp Pro Glu Pro Gly Pro Gly Gly Gly Met Ala His Gly 
            100                 105                 110         


Thr Thr Arg His Leu Ala Ala Arg Tyr Gly Leu Pro Ala Ala Trp Ser 
        115                 120                 125             


Thr Phe Ala Tyr Ser Leu Arg Pro Ser Arg Ser Pro Leu Arg Ala Leu 
    130                 135                 140                 


Ile Glu Met Val Val Ala Arg Glu Pro Ser Ala Ser Leu Gly Gln Leu 
145                 150                 155                 160 


Gly Thr His Leu Ala Gln Leu Gly Arg Ala Asp Ala Leu Arg Val Leu 
                165                 170                 175     


Ser Lys Leu Gly Ser Ser Gly Val Cys Trp Ala 
            180                 185         


<210>  290
<211>  138
<212>  PRT
<213>  Homo sapiens

<400>  290

Met Gly Pro Gly Arg Cys Leu Leu Thr Ala Leu Leu Leu Leu Ala Leu 
1               5                   10                  15      


Ala Pro Pro Pro Glu Ala Ser Gln Tyr Cys Gly Arg Leu Glu Tyr Trp 
            20                  25                  30          


Asn Pro Asp Asn Lys Cys Cys Ser Ser Cys Leu Gln Arg Phe Gly Pro 
        35                  40                  45              


Pro Pro Cys Pro Asp Tyr Glu Phe Arg Glu Asn Cys Gly Leu Asn Asp 
    50                  55                  60                  


His Gly Asp Phe Val Thr Pro Pro Phe Arg Lys Cys Ser Ser Gly Gln 
65                  70                  75                  80  


Cys Asn Pro Asp Gly Ala Glu Leu Cys Ser Pro Cys Gly Gly Gly Ala 
                85                  90                  95      


Val Thr Pro Thr Pro Ala Ala Gly Gly Gly Arg Thr Pro Trp Arg Cys 
            100                 105                 110         


Arg Glu Arg Pro Val Pro Ala Lys Gly His Cys Pro Leu Thr Pro Gly 
        115                 120                 125             


Asn Pro Gly Ala Pro Ser Ser Gln Glu Arg 
    130                 135             


<210>  291
<211>  74
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  291

Xaa Asn Cys Gly Leu Asn Asp His Gly Asp Phe Val Thr Pro Pro Phe 
1               5                   10                  15      


Arg Lys Cys Ser Ser Gly Gln Cys Asn Pro Asp Gly Ala Glu Leu Cys 
            20                  25                  30          


Ser Pro Cys Gly Gly Gly Ala Val Thr Pro Thr Pro Ala Ala Gly Gly 
        35                  40                  45              


Gly Arg Thr Pro Trp Arg Cys Arg Glu Ala Pro Trp Arg Gln Gly Thr 
    50                  55                  60                  


His Gly Arg Arg Pro His Tyr Phe His Ser 
65                  70                  


<210>  292
<211>  355
<212>  PRT
<213>  Homo sapiens

<400>  292

Met Gly Pro Gly Arg Cys Leu Leu Thr Ala Leu Leu Leu Leu Ala Leu 
1               5                   10                  15      


Ala Pro Pro Pro Glu Ala Ser Gln Tyr Cys Gly Arg Leu Glu Tyr Trp 
            20                  25                  30          


Asn Pro Asp Asn Lys Cys Cys Ser Ser Cys Leu Gln Arg Phe Gly Pro 
        35                  40                  45              


Pro Pro Cys Pro Asp Tyr Glu Phe Arg Glu Asn Cys Gly Leu Asn Asp 
    50                  55                  60                  


His Gly Asp Phe Val Thr Pro Pro Phe Arg Lys Cys Ser Ser Gly Gln 
65                  70                  75                  80  


Cys Asn Pro Asp Gly Ala Glu Leu Cys Ser Pro Cys Gly Gly Gly Ala 
                85                  90                  95      


Val Thr Pro Thr Pro Ala Ala Gly Gly Gly Arg Thr Pro Trp Arg Cys 
            100                 105                 110         


Arg Glu Arg Pro Val Pro Ala Lys Gly His Cys Pro Leu Thr Pro Gly 
        115                 120                 125             


Asn Pro Gly Ala Pro Ser Ser Gln Glu Arg Ser Ser Pro Ala Ser Ser 
    130                 135                 140                 


Ile Ala Trp Arg Thr Pro Glu Pro Val Pro Gln Gln Ala Trp Pro Asn 
145                 150                 155                 160 


Phe Leu Pro Leu Val Val Leu Val Leu Leu Leu Thr Leu Ala Val Ile 
                165                 170                 175     


Ala Ile Leu Leu Phe Ile Leu Leu Trp His Leu Cys Trp Pro Lys Glu 
            180                 185                 190         


Lys Ala Asp Pro Tyr Pro Tyr Pro Gly Leu Val Cys Gly Val Pro Asn 
        195                 200                 205             


Thr His Thr Pro Ser Ser Ser His Leu Ser Ser Pro Gly Ala Leu Glu 
    210                 215                 220                 


Thr Gly Asp Thr Trp Lys Glu Ala Ser Leu Leu Pro Leu Leu Ser Arg 
225                 230                 235                 240 


Glu Leu Ser Ser Leu Ala Ser Gln Pro Leu Ser Arg Leu Leu Asp Glu 
                245                 250                 255     


Leu Glu Val Leu Glu Glu Leu Ile Val Leu Leu Asp Pro Glu Pro Gly 
            260                 265                 270         


Pro Gly Gly Gly Met Ala His Gly Thr Thr Arg His Leu Ala Ala Arg 
        275                 280                 285             


Tyr Gly Leu Pro Ala Ala Trp Ser Thr Phe Ala Tyr Ser Leu Arg Pro 
    290                 295                 300                 


Ser Arg Ser Pro Leu Arg Ala Leu Ile Glu Met Val Val Ala Arg Glu 
305                 310                 315                 320 


Pro Ser Ala Ser Leu Gly Gln Leu Gly Thr His Leu Ala Gln Leu Gly 
                325                 330                 335     


Arg Ala Asp Ala Leu Arg Val Leu Ser Lys Leu Gly Ser Ser Gly Val 
            340                 345                 350         


Cys Trp Ala 
        355 


<210>  293
<211>  60
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  293

Xaa Gly Arg Leu Glu Tyr Trp Asn Pro Asp Asn Lys Cys Cys Ser Ser 
1               5                   10                  15      


Cys Leu Gln Arg Phe Gly Pro Pro Pro Cys Pro Gly Glu Asn Pro Arg 
            20                  25                  30          


Pro Ser Leu Ala Trp Ala Glu Leu Ala Glu Ala Gly Pro Cys Gln Gly 
        35                  40                  45              


Ala Leu Pro Pro His Thr Trp Lys Pro Arg Arg Pro 
    50                  55                  60  


<210>  294
<211>  167
<212>  PRT
<213>  Homo sapiens

<400>  294

Met Gly Pro Gly Arg Cys Leu Leu Thr Ala Leu Leu Leu Leu Ala Leu 
1               5                   10                  15      


Ala Pro Pro Pro Glu Ala Ser Gln Tyr Cys Gly Arg Leu Glu Tyr Trp 
            20                  25                  30          


Asn Pro Asp Asn Lys Cys Cys Ser Ser Cys Leu Gln Arg Phe Gly Pro 
        35                  40                  45              


Pro Pro Cys Pro Glu Leu Ser Ser Leu Ala Ser Gln Pro Leu Ser Arg 
    50                  55                  60                  


Leu Leu Asp Glu Leu Glu Val Leu Glu Glu Leu Ile Val Leu Leu Asp 
65                  70                  75                  80  


Pro Glu Pro Gly Pro Gly Gly Gly Met Ala His Gly Thr Thr Arg His 
                85                  90                  95      


Leu Ala Ala Arg Tyr Gly Leu Pro Ala Ala Trp Ser Thr Phe Ala Tyr 
            100                 105                 110         


Ser Leu Arg Pro Ser Arg Ser Pro Leu Arg Ala Leu Ile Glu Met Val 
        115                 120                 125             


Val Ala Arg Glu Pro Ser Ala Ser Leu Gly Gln Leu Gly Thr His Leu 
    130                 135                 140                 


Ala Gln Leu Gly Arg Ala Asp Ala Leu Arg Val Leu Ser Lys Leu Gly 
145                 150                 155                 160 


Ser Ser Gly Val Cys Trp Ala 
                165         


<210>  295
<211>  1742
<212>  PRT
<213>  Homo sapiens

<400>  295

Met Ala Val Ala Glu Leu Tyr Thr Gln Tyr Asn Arg Val Trp Ile Pro 
1               5                   10                  15      


Asp Pro Glu Glu Val Trp Lys Ser Ala Glu Ile Ala Lys Asp Tyr Arg 
            20                  25                  30          


Val Gly Asp Lys Val Leu Arg Leu Leu Leu Glu Asp Gly Thr Glu Leu 
        35                  40                  45              


Asp Tyr Ser Val Asn Pro Glu Ser Leu Pro Pro Leu Arg Asn Pro Asp 
    50                  55                  60                  


Ile Leu Val Gly Glu Asn Asp Leu Thr Ala Leu Ser Tyr Leu His Glu 
65                  70                  75                  80  


Pro Ala Val Leu His Asn Leu Arg Ile Arg Phe Ala Glu Ser Lys Leu 
                85                  90                  95      


Ile Tyr Thr Tyr Ser Gly Ile Ile Leu Val Ala Met Asn Pro Tyr Lys 
            100                 105                 110         


Gln Leu Pro Ile Tyr Gly Asp Ala Ile Ile His Ala Tyr Ser Gly Gln 
        115                 120                 125             


Asn Met Gly Asp Met Asp Pro His Ile Phe Ala Val Ala Glu Glu Ala 
    130                 135                 140                 


Tyr Lys Gln Met Ala Arg Asn Asn Arg Asn Gln Ser Ile Ile Val Ser 
145                 150                 155                 160 


Gly Glu Ser Gly Ala Gly Lys Thr Val Ser Ala Arg Tyr Ala Met Arg 
                165                 170                 175     


Tyr Phe Ala Thr Val Ser Lys Ser Gly Ser Asn Ala His Val Glu Asp 
            180                 185                 190         


Lys Val Leu Ala Ser Asn Pro Ile Thr Glu Ala Val Gly Asn Ala Lys 
        195                 200                 205             


Thr Thr Arg Asn Asp Asn Ser Ser Arg Phe Gly Lys Tyr Thr Glu Ile 
    210                 215                 220                 


Ser Phe Asp Glu Gln Asn Gln Ile Ile Gly Ala Asn Met Ser Thr Tyr 
225                 230                 235                 240 


Leu Leu Glu Lys Ser Arg Val Val Phe Gln Ser Glu Asn Glu Arg Asn 
                245                 250                 255     


Tyr His Ile Phe Tyr Gln Leu Cys Ala Ser Ala Gln Gln Ser Glu Phe 
            260                 265                 270         


Lys His Leu Lys Leu Gly Ser Ala Glu Glu Phe Asn Tyr Thr Arg Met 
        275                 280                 285             


Gly Gly Asn Thr Val Ile Glu Gly Val Asn Asp Arg Ala Glu Met Val 
    290                 295                 300                 


Glu Thr Gln Lys Thr Phe Thr Leu Leu Gly Phe Lys Glu Asp Phe Gln 
305                 310                 315                 320 


Met Asp Val Phe Lys Ile Leu Ala Ala Ile Leu His Leu Gly Asn Val 
                325                 330                 335     


Gln Ile Thr Ala Val Gly Asn Glu Arg Ser Ser Val Ser Glu Asp Asp 
            340                 345                 350         


Ser His Leu Lys Val Phe Cys Glu Leu Leu Gly Leu Glu Ser Gly Arg 
        355                 360                 365             


Val Ala Gln Trp Leu Cys Asn Arg Lys Ile Val Thr Ser Ser Glu Thr 
    370                 375                 380                 


Val Val Lys Pro Met Thr Arg Pro Gln Ala Val Asn Ala Arg Asp Ala 
385                 390                 395                 400 


Leu Ala Lys Lys Ile Tyr Ala His Leu Phe Asp Phe Ile Val Glu Arg 
                405                 410                 415     


Ile Asn Gln Ala Leu Gln Phe Ser Gly Lys Gln His Thr Phe Ile Gly 
            420                 425                 430         


Val Leu Asp Ile Tyr Gly Phe Glu Thr Phe Asp Val Asn Ser Phe Glu 
        435                 440                 445             


Gln Phe Cys Ile Asn Tyr Ala Asn Glu Lys Leu Gln Gln Gln Phe Asn 
    450                 455                 460                 


Met His Val Phe Lys Leu Glu Gln Glu Glu Tyr Met Lys Glu Asp Ile 
465                 470                 475                 480 


Pro Trp Thr Leu Ile Asp Phe Tyr Asp Asn Gln Pro Val Ile Asp Leu 
                485                 490                 495     


Ile Glu Ala Lys Met Gly Ile Leu Glu Leu Leu Asp Glu Glu Cys Leu 
            500                 505                 510         


Leu Pro His Gly Thr Asp Glu Asn Trp Leu Gln Lys Leu Tyr Asn Asn 
        515                 520                 525             


Phe Val Asn Arg Asn Pro Leu Phe Glu Lys Pro Arg Met Ser Asn Thr 
    530                 535                 540                 


Ser Phe Val Ile Gln His Phe Ala Asp Lys Val Glu Tyr Lys Cys Glu 
545                 550                 555                 560 


Gly Phe Leu Glu Lys Asn Arg Asp Thr Val Tyr Asp Met Leu Val Glu 
                565                 570                 575     


Ile Leu Arg Ala Ser Lys Phe His Leu Cys Ala Asn Phe Phe Gln Glu 
            580                 585                 590         


Asn Pro Thr Pro Pro Ser Pro Phe Gly Ser Met Ile Thr Val Lys Ser 
        595                 600                 605             


Ala Lys Gln Val Ile Lys Pro Asn Ser Lys His Phe Arg Thr Thr Val 
    610                 615                 620                 


Gly Ser Lys Phe Arg Ser Ser Leu Tyr Leu Leu Met Glu Thr Leu Asn 
625                 630                 635                 640 


Ala Thr Thr Pro His Tyr Val Arg Cys Ile Lys Pro Asn Asp Glu Lys 
                645                 650                 655     


Leu Pro Phe Glu Phe Asp Ser Lys Arg Ile Val Gln Gln Leu Arg Ala 
            660                 665                 670         


Cys Gly Val Leu Glu Thr Ile Arg Ile Ser Ala Gln Ser Tyr Pro Ser 
        675                 680                 685             


Arg Trp Thr Tyr Ile Glu Phe Tyr Ser Arg Tyr Gly Ile Leu Met Thr 
    690                 695                 700                 


Lys Gln Glu Leu Ser Phe Ser Asp Lys Lys Glu Val Cys Lys Val Val 
705                 710                 715                 720 


Leu His Arg Leu Ile Gln Asp Ser Asn Gln Tyr Gln Phe Gly Lys Thr 
                725                 730                 735     


Lys Ile Phe Phe Arg Ala Gly Gln Val Ala Tyr Leu Glu Lys Leu Arg 
            740                 745                 750         


Leu Asp Lys Leu Arg Gln Ser Cys Val Met Val Gln Lys His Met Arg 
        755                 760                 765             


Gly Trp Leu Gln Arg Lys Lys Phe Leu Arg Glu Arg Arg Ala Ala Leu 
    770                 775                 780                 


Ile Ile Gln Gln Tyr Phe Arg Gly Gln Gln Thr Val Arg Lys Ala Ile 
785                 790                 795                 800 


Thr Ala Val Ala Leu Lys Glu Ala Trp Ala Ala Ile Ile Ile Gln Lys 
                805                 810                 815     


His Cys Arg Gly Tyr Leu Val Arg Ser Leu Tyr Gln Leu Ile Arg Met 
            820                 825                 830         


Ala Thr Ile Thr Met Gln Ala Tyr Ser Arg Gly Phe Leu Ala Arg Arg 
        835                 840                 845             


Arg Tyr Arg Lys Met Leu Glu Glu His Lys Ala Val Ile Leu Gln Lys 
    850                 855                 860                 


Tyr Ala Arg Ala Trp Leu Ala Arg Arg Arg Phe Gln Ser Ile Arg Arg 
865                 870                 875                 880 


Phe Val Leu Asn Ile Gln Leu Thr Tyr Arg Val Gln Arg Leu Gln Lys 
                885                 890                 895     


Lys Leu Glu Asp Gln Asn Lys Glu Asn His Gly Leu Val Glu Lys Leu 
            900                 905                 910         


Thr Ser Leu Ala Ala Leu Arg Ala Gly Asp Val Glu Lys Ile Gln Lys 
        915                 920                 925             


Leu Glu Ala Glu Leu Glu Lys Ala Ala Thr His Arg Arg Asn Tyr Glu 
    930                 935                 940                 


Glu Lys Gly Lys Arg Tyr Arg Asp Ala Val Glu Glu Lys Leu Ala Lys 
945                 950                 955                 960 


Leu Gln Lys His Asn Ser Glu Leu Glu Thr Gln Lys Glu Gln Ile Gln 
                965                 970                 975     


Leu Lys Leu Gln Glu Lys Thr Glu Glu Leu Lys Glu Lys Met Asp Asn 
            980                 985                 990         


Leu Thr Lys Gln Leu Phe Asp Asp  Val Gln Lys Glu Glu  Arg Gln Arg 
        995                 1000                 1005             


Met Leu  Leu Glu Lys Ser Phe  Glu Leu Lys Thr Gln  Asp Tyr Glu 
    1010                 1015                 1020             


Lys Gln  Ile Gln Ser Leu Lys  Glu Glu Ile Lys Ala  Leu Lys Asp 
    1025                 1030                 1035             


Glu Lys  Met Gln Leu Gln His  Leu Val Glu Gly Glu  His Val Thr 
    1040                 1045                 1050             


Ser Asp  Gly Leu Lys Ala Glu  Val Ala Arg Leu Ser  Lys Gln Val 
    1055                 1060                 1065             


Lys Thr  Ile Ser Glu Phe Glu  Lys Glu Ile Glu Leu  Leu Gln Ala 
    1070                 1075                 1080             


Gln Lys  Ile Asp Val Glu Lys  His Val Gln Ser Gln  Lys Arg Glu 
    1085                 1090                 1095             


Met Arg  Glu Lys Met Ser Glu  Ile Thr Lys Gln Leu  Leu Glu Ser 
    1100                 1105                 1110             


Tyr Asp  Ile Glu Asp Val Arg  Ser Arg Leu Ser Val  Glu Asp Leu 
    1115                 1120                 1125             


Glu His  Leu Asn Glu Asp Gly  Glu Leu Trp Phe Ala  Tyr Glu Gly 
    1130                 1135                 1140             


Leu Lys  Lys Ala Thr Arg Val  Leu Glu Ser His Phe  Gln Ser Gln 
    1145                 1150                 1155             


Lys Asp  Cys Tyr Glu Lys Glu  Ile Glu Ala Leu Asn  Phe Lys Val 
    1160                 1165                 1170             


Val His  Leu Ser Gln Glu Ile  Asn His Leu Gln Lys  Leu Phe Arg 
    1175                 1180                 1185             


Glu Glu  Asn Asp Ile Asn Glu  Ser Ile Arg His Glu  Val Thr Arg 
    1190                 1195                 1200             


Leu Thr  Ser Glu Asn Met Met  Ile Pro Asp Phe Lys  Gln Gln Ile 
    1205                 1210                 1215             


Ser Glu  Leu Glu Lys Gln Lys  Gln Asp Leu Glu Ile  Arg Leu Asn 
    1220                 1225                 1230             


Glu Gln  Ala Glu Lys Met Lys  Gly Lys Leu Glu Glu  Leu Ser Asn 
    1235                 1240                 1245             


Gln Leu  His Arg Ser Gln Glu  Glu Glu Gly Thr Gln  Arg Lys Ala 
    1250                 1255                 1260             


Leu Glu  Ala Gln Asn Glu Ile  His Thr Lys Glu Lys  Glu Lys Leu 
    1265                 1270                 1275             


Ile Asp  Lys Ile Gln Glu Met  Gln Glu Ala Ser Asp  His Leu Lys 
    1280                 1285                 1290             


Lys Gln  Phe Glu Thr Glu Ser  Glu Val Lys Cys Asn  Phe Arg Gln 
    1295                 1300                 1305             


Glu Ala  Ser Arg Leu Thr Leu  Glu Asn Arg Asp Leu  Glu Glu Glu 
    1310                 1315                 1320             


Leu Asp  Met Lys Asp Arg Val  Ile Lys Lys Leu Gln  Asp Gln Val 
    1325                 1330                 1335             


Lys Thr  Leu Ser Lys Thr Ile  Gly Lys Ala Asn Asp  Val His Ser 
    1340                 1345                 1350             


Ser Ser  Gly Pro Lys Glu Tyr  Leu Gly Met Leu Gln  Tyr Lys Arg 
    1355                 1360                 1365             


Glu Asp  Glu Ala Lys Leu Ile  Gln Asn Leu Ile Leu  Asp Leu Lys 
    1370                 1375                 1380             


Pro Arg  Gly Val Val Val Asn  Met Ile Pro Gly Leu  Pro Ala His 
    1385                 1390                 1395             


Ile Leu  Phe Met Cys Val Arg  Tyr Ala Asp Ser Leu  Asn Asp Ala 
    1400                 1405                 1410             


Asn Met  Leu Lys Ser Leu Met  Asn Ser Thr Ile Asn  Gly Ile Lys 
    1415                 1420                 1425             


Gln Val  Val Lys Glu His Leu  Glu Asp Phe Glu Met  Leu Ser Phe 
    1430                 1435                 1440             


Trp Leu  Ser Asn Thr Cys His  Phe Leu Asn Cys Leu  Lys Gln Tyr 
    1445                 1450                 1455             


Ser Gly  Glu Glu Glu Phe Met  Lys His Asn Ser Pro  Gln Gln Asn 
    1460                 1465                 1470             


Lys Asn  Cys Leu Asn Asn Phe  Asp Leu Ser Glu Tyr  Arg Gln Ile 
    1475                 1480                 1485             


Leu Ser  Asp Val Ala Ile Arg  Ile Tyr His Gln Phe  Ile Ile Ile 
    1490                 1495                 1500             


Met Glu  Lys Asn Ile Gln Pro  Ile Ile Val Pro Gly  Met Leu Glu 
    1505                 1510                 1515             


Tyr Glu  Ser Leu Gln Gly Ile  Ser Gly Leu Lys Pro  Thr Gly Phe 
    1520                 1525                 1530             


Arg Lys  Arg Ser Ser Ser Ile  Asp Asp Thr Asp Gly  Tyr Thr Met 
    1535                 1540                 1545             


Thr Ser  Val Leu Gln Gln Leu  Ser Tyr Phe Tyr Thr  Thr Met Cys 
    1550                 1555                 1560             


Gln Asn  Gly Leu Asp Pro Glu  Leu Val Arg Gln Ala  Val Lys Gln 
    1565                 1570                 1575             


Leu Phe  Phe Leu Ile Gly Ala  Val Thr Leu Asn Ser  Leu Phe Leu 
    1580                 1585                 1590             


Arg Lys  Asp Met Cys Ser Cys  Arg Lys Gly Met Gln  Ile Arg Cys 
    1595                 1600                 1605             


Asn Ile  Ser Tyr Leu Glu Glu  Trp Leu Lys Asp Lys  Asn Leu Gln 
    1610                 1615                 1620             


Asn Ser  Leu Ala Lys Glu Thr  Leu Glu Pro Leu Ser  Gln Ala Ala 
    1625                 1630                 1635             


Trp Leu  Leu Gln Val Lys Lys  Thr Thr Asp Ser Asp  Ala Lys Glu 
    1640                 1645                 1650             


Ile Tyr  Glu Arg Cys Thr Ser  Leu Ser Ala Val Gln  Ile Ile Lys 
    1655                 1660                 1665             


Ile Leu  Asn Ser Tyr Thr Pro  Ile Asp Asp Phe Glu  Lys Arg Val 
    1670                 1675                 1680             


Thr Pro  Ser Phe Val Arg Lys  Val Gln Ala Leu Leu  Asn Ser Arg 
    1685                 1690                 1695             


Glu Asp  Ser Ser Gln Leu Met  Leu Asp Thr Lys Tyr  Leu Phe Gln 
    1700                 1705                 1710             


Val Thr  Phe Pro Phe Thr Pro  Ser Pro His Ala Leu  Glu Met Ile 
    1715                 1720                 1725             


Gln Ile  Pro Ser Ser Phe Lys  Leu Gly Phe Leu Asn  Arg Leu 
    1730                 1735                 1740         


<210>  296
<211>  612
<212>  PRT
<213>  Homo sapiens

<400>  296

Met Ala Ala Ala Gly Arg Leu Pro Ser Ser Trp Ala Leu Phe Ser Pro 
1               5                   10                  15      


Leu Leu Ala Gly Leu Ala Leu Leu Gly Val Gly Pro Val Pro Ala Arg 
            20                  25                  30          


Ala Leu His Asn Val Thr Ala Glu Leu Phe Gly Ala Glu Ala Trp Gly 
        35                  40                  45              


Thr Leu Ala Ala Phe Gly Asp Leu Asn Ser Asp Lys Gln Thr Asp Leu 
    50                  55                  60                  


Phe Val Leu Arg Glu Arg Asn Asp Leu Ile Val Phe Leu Ala Asp Gln 
65                  70                  75                  80  


Asn Ala Pro Tyr Phe Lys Pro Lys Val Lys Val Ser Phe Lys Asn His 
                85                  90                  95      


Ser Ala Leu Ile Thr Ser Val Val Pro Gly Asp Tyr Asp Gly Asp Ser 
            100                 105                 110         


Gln Met Asp Val Leu Leu Thr Tyr Leu Pro Lys Asn Tyr Ala Lys Ser 
        115                 120                 125             


Glu Leu Gly Ala Val Ile Phe Trp Gly Gln Asn Gln Thr Leu Asp Pro 
    130                 135                 140                 


Asn Asn Met Thr Ile Leu Asn Arg Thr Phe Gln Asp Glu Pro Leu Ile 
145                 150                 155                 160 


Met Asp Phe Asn Gly Asp Leu Ile Pro Asp Ile Phe Gly Ile Thr Asn 
                165                 170                 175     


Glu Ser Asn Gln Pro Gln Ile Leu Leu Gly Gly Asn Leu Ser Trp His 
            180                 185                 190         


Pro Ala Leu Thr Thr Thr Ser Lys Met Arg Ile Pro His Ser His Ala 
        195                 200                 205             


Phe Ile Asp Leu Thr Glu Asp Phe Thr Ala Asp Leu Phe Leu Thr Thr 
    210                 215                 220                 


Leu Asn Ala Thr Thr Ser Thr Phe Gln Phe Glu Ile Trp Glu Asn Leu 
225                 230                 235                 240 


Asp Gly Asn Phe Ser Val Ser Thr Ile Leu Glu Lys Pro Gln Asn Met 
                245                 250                 255     


Met Val Val Gly Gln Ser Ala Phe Ala Asp Phe Asp Gly Asp Gly His 
            260                 265                 270         


Met Asp His Leu Leu Pro Gly Cys Glu Asp Lys Asn Cys Gln Lys Ser 
        275                 280                 285             


Thr Ile Tyr Leu Val Arg Ser Gly Met Lys Gln Trp Val Pro Val Leu 
    290                 295                 300                 


Gln Asp Phe Ser Asn Lys Gly Thr Leu Trp Gly Phe Val Pro Phe Val 
305                 310                 315                 320 


Asp Glu Gln Gln Pro Thr Glu Ile Pro Ile Pro Ile Thr Leu His Ile 
                325                 330                 335     


Gly Asp Tyr Asn Met Asp Gly Tyr Pro Asp Ala Leu Val Ile Leu Lys 
            340                 345                 350         


Asn Thr Ser Gly Ser Asn Gln Gln Ala Phe Leu Leu Glu Asn Val Pro 
        355                 360                 365             


Cys Asn Asn Ala Ser Cys Glu Glu Ala Arg Arg Met Phe Lys Val Tyr 
    370                 375                 380                 


Trp Glu Leu Thr Asp Leu Asn Gln Ile Lys Asp Ala Met Val Ala Thr 
385                 390                 395                 400 


Phe Phe Asp Ile Tyr Glu Asp Gly Ile Leu Asp Ile Val Val Leu Ser 
                405                 410                 415     


Lys Gly Tyr Thr Lys Asn Asp Phe Ala Ile His Thr Leu Lys Asn Asn 
            420                 425                 430         


Phe Glu Ala Asp Ala Tyr Phe Val Lys Val Ile Val Leu Ser Gly Leu 
        435                 440                 445             


Cys Ser Asn Asp Cys Pro Arg Lys Ile Thr Pro Phe Gly Val Asn Gln 
    450                 455                 460                 


Pro Gly Pro Tyr Ile Met Tyr Thr Thr Val Asp Ala Asn Gly Tyr Leu 
465                 470                 475                 480 


Lys Asn Gly Ser Ala Gly Gln Leu Ser Gln Ser Ala His Leu Ala Leu 
                485                 490                 495     


Gln Leu Pro Tyr Asn Val Leu Gly Leu Gly Arg Ser Ala Asn Phe Leu 
            500                 505                 510         


Asp His Leu Tyr Val Gly Ile Pro Arg Pro Ser Gly Glu Lys Ser Ile 
        515                 520                 525             


Arg Lys Gln Glu Trp Thr Ala Ile Ile Pro Asn Ser Gln Leu Ile Val 
    530                 535                 540                 


Ile Pro Tyr Pro His Asn Val Pro Arg Ser Trp Ser Ala Lys Leu Tyr 
545                 550                 555                 560 


Leu Thr Pro Ser Asn Ile Val Leu Leu Thr Ala Ile Ala Leu Ile Gly 
                565                 570                 575     


Val Cys Val Phe Ile Leu Ala Ile Ile Gly Ile Leu His Trp Gln Glu 
            580                 585                 590         


Lys Lys Ala Asp Asp Arg Glu Lys Arg Gln Glu Ala His Arg Phe His 
        595                 600                 605             


Phe Asp Ala Met 
    610         


<210>  297
<211>  464
<212>  PRT
<213>  Homo sapiens

<400>  297

Met Asp Val Leu Leu Thr Tyr Leu Pro Lys Asn Tyr Ala Lys Ser Glu 
1               5                   10                  15      


Leu Gly Ala Val Ile Phe Trp Gly Gln Asn Gln Thr Leu Asp Pro Asn 
            20                  25                  30          


Asn Met Thr Ile Leu Asn Arg Thr Phe Gln Asp Glu Pro Leu Ile Met 
        35                  40                  45              


Asp Phe Asn Gly Asp Leu Ile Pro Asp Ile Phe Gly Ile Thr Asn Glu 
    50                  55                  60                  


Ser Asn Gln Pro Gln Ile Leu Leu Gly Gly Asn Leu Ser Trp His Pro 
65                  70                  75                  80  


Ala Leu Thr Thr Thr Ser Lys Met Arg Ile Pro His Ser His Ala Phe 
                85                  90                  95      


Ile Asp Leu Thr Glu Asp Phe Thr Ala Asp Leu Phe Leu Thr Thr Leu 
            100                 105                 110         


Asn Ala Thr Thr Ser Thr Phe Gln Phe Glu Ile Trp Glu Asn Leu Asp 
        115                 120                 125             


Gly Asn Phe Ser Val Ser Thr Ile Leu Glu Lys Pro Gln Asn Met Met 
    130                 135                 140                 


Val Val Gly Gln Ser Ala Phe Ala Asp Phe Asp Gly Asp Gly His Met 
145                 150                 155                 160 


Asp His Leu Leu Pro Gly Cys Glu Asp Lys Asn Cys Gln Lys Ser Thr 
                165                 170                 175     


Ile Tyr Leu Val Arg Ser Gly Met Lys Gln Trp Val Pro Val Leu Gln 
            180                 185                 190         


Asp Phe Ser Asn Lys Gly Thr Leu Trp Gly Phe Val Pro Phe Val Asp 
        195                 200                 205             


Glu Gln Gln Pro Thr Glu Ile Pro Ile Pro Ile Thr Leu His Ile Gly 
    210                 215                 220                 


Asp Tyr Asn Met Asp Gly Tyr Pro Asp Ala Leu Val Ile Leu Lys Asn 
225                 230                 235                 240 


Thr Ser Gly Ser Asn Gln Gln Ala Phe Leu Leu Glu Asn Val Pro Cys 
                245                 250                 255     


Asn Asn Ala Ser Cys Glu Glu Ala Arg Arg Met Phe Lys Val Tyr Trp 
            260                 265                 270         


Glu Leu Thr Asp Leu Asn Gln Ile Lys Asp Ala Met Val Ala Thr Phe 
        275                 280                 285             


Phe Asp Ile Tyr Glu Asp Gly Ile Leu Asp Ile Val Val Leu Ser Lys 
    290                 295                 300                 


Gly Tyr Thr Lys Asn Asp Phe Ala Ile His Thr Leu Lys Asn Asn Phe 
305                 310                 315                 320 


Glu Ala Asp Ala Tyr Phe Val Lys Val Ile Val Leu Ser Gly Leu Cys 
                325                 330                 335     


Ser Asn Asp Cys Pro Arg Lys Ile Thr Pro Phe Gly Val Asn Gln Pro 
            340                 345                 350         


Gly Pro Tyr Ile Met Tyr Thr Thr Val Asp Ala Asn Gly Tyr Leu Lys 
        355                 360                 365             


Asn Gly Ser Ala Gly Gln Leu Ser Gln Ser Ala His Leu Ala Leu Gln 
    370                 375                 380                 


Leu Pro Tyr Asn Val Leu Gly Leu Gly Arg Ser Ala Asn Phe Leu Asp 
385                 390                 395                 400 


His Leu Tyr Val Gly Ile Pro Arg Pro Ser Gly Glu Lys Ser Ile Arg 
                405                 410                 415     


Lys Gln Glu Trp Thr Ala Ile Ile Pro Asn Ser Gln Leu Ile Val Ile 
            420                 425                 430         


Pro Tyr Pro His Asn Val Pro Arg Ser Ser His Arg Cys Leu Cys Phe 
        435                 440                 445             


His Leu Gly Asn Asn Trp His Phe Thr Leu Ala Gly Lys Glu Ser Arg 
    450                 455                 460                 


<210>  298
<211>  74
<212>  PRT
<213>  Homo sapiens

<400>  298

Met Asp Val Leu Leu Thr Tyr Leu Pro Lys Asn Tyr Ala Lys Ser Glu 
1               5                   10                  15      


Leu Gly Ala Val Ile Phe Trp Gly Gln Asn Gln Thr Leu Asp Pro Asn 
            20                  25                  30          


Asn Met Thr Ile Leu Asn Arg Thr Phe Gln Asp Glu Pro Leu Ile Met 
        35                  40                  45              


Asp Phe Asn Gly Asp Leu Ile Pro Asp Ile Phe Gly Ile Thr Asn Glu 
    50                  55                  60                  


Ser Asn Gln Pro Gln Ile Leu Leu Gly Gly 
65                  70                  


<210>  299
<211>  178
<212>  PRT
<213>  Homo sapiens

<400>  299

Val Leu Ser Lys Gly Tyr Thr Lys Asn Asp Phe Ala Ile His Thr Leu 
1               5                   10                  15      


Lys Asn Asn Phe Glu Ala Asp Ala Tyr Phe Val Lys Val Ile Val Leu 
            20                  25                  30          


Ser Gly Leu Cys Ser Asn Asp Cys Pro Arg Lys Ile Thr Pro Phe Gly 
        35                  40                  45              


Val Asn Gln Pro Gly Pro Tyr Ile Met Tyr Thr Thr Val Asp Ala Asn 
    50                  55                  60                  


Gly Tyr Leu Lys Asn Gly Ser Gly Arg Ser Ala Asn Phe Leu Asp His 
65                  70                  75                  80  


Leu Tyr Val Gly Ile Pro Arg Pro Ser Gly Glu Lys Ser Ile Arg Lys 
                85                  90                  95      


Gln Glu Trp Thr Ala Ile Ile Pro Asn Ser Gln Leu Ile Val Ile Pro 
            100                 105                 110         


Tyr Pro His Asn Val Pro Arg Ser Trp Ser Ala Lys Leu Tyr Leu Thr 
        115                 120                 125             


Pro Ser Asn Ile Val Leu Leu Thr Ala Ile Ala Leu Ile Gly Val Cys 
    130                 135                 140                 


Val Phe Ile Leu Ala Ile Ile Gly Ile Leu His Trp Gln Glu Lys Lys 
145                 150                 155                 160 


Ala Asp Asp Arg Glu Lys Arg Gln Glu Ala His Arg Phe His Phe Asp 
                165                 170                 175     


Ala Met 
        


<210>  300
<211>  113
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  300

Xaa Lys Pro Lys Val Lys Val Ser Phe Lys Asn His Ser Ala Leu Ile 
1               5                   10                  15      


Thr Ser Val Val Pro Gly Asp Tyr Asp Gly Asp Ser Gln Met Asp Val 
            20                  25                  30          


Leu Leu Thr Tyr Leu Pro Lys Asn Tyr Ala Lys Ser Glu Leu Gly Ala 
        35                  40                  45              


Val Ile Phe Trp Gly Gln Asn Gln Thr Leu Asp Pro Asn Asn Met Thr 
    50                  55                  60                  


Ile Leu Asn Arg Thr Phe Gln Asp Glu Pro Leu Ile Met Asp Phe Asn 
65                  70                  75                  80  


Gly Asp Leu Ile Pro Asp Ile Phe Gly Ile Thr Asn Glu Ser Asn Gln 
                85                  90                  95      


Pro Gln Ile Leu Leu Gly Gly His Thr Thr Leu Asn Ala Pro His Leu 
            100                 105                 110         


Phe 
    


<210>  301
<211>  431
<212>  PRT
<213>  Homo sapiens

<400>  301

Met Ala Glu Ile Thr Asn Ile Arg Pro Ser Phe Asp Val Ser Pro Val 
1               5                   10                  15      


Val Ala Gly Leu Ile Gly Ala Ser Val Leu Val Val Cys Val Ser Val 
            20                  25                  30          


Thr Val Phe Val Trp Ser Cys Cys His Gln Gln Ala Glu Lys Lys Gln 
        35                  40                  45              


Lys Asn Pro Pro Tyr Lys Phe Ile His Met Leu Lys Gly Ile Ser Ile 
    50                  55                  60                  


Tyr Pro Glu Thr Leu Ser Asn Lys Lys Lys Ile Ile Lys Val Arg Arg 
65                  70                  75                  80  


Asp Lys Asp Gly Pro Gly Arg Glu Gly Gly Arg Arg Asn Leu Leu Val 
                85                  90                  95      


Asp Ala Ala Glu Ala Gly Leu Leu Ser Arg Asp Lys Asp Pro Arg Gly 
            100                 105                 110         


Pro Ser Ser Gly Ser Cys Ile Asp Gln Leu Pro Ile Lys Met Asp Tyr 
        115                 120                 125             


Gly Glu Glu Leu Arg Ser Pro Ile Thr Ser Leu Thr Pro Gly Glu Ser 
    130                 135                 140                 


Lys Thr Thr Ser Pro Ser Ser Pro Glu Glu Asp Val Met Leu Gly Ser 
145                 150                 155                 160 


Leu Thr Phe Ser Val Asp Tyr Asn Phe Pro Lys Lys Ala Leu Val Val 
                165                 170                 175     


Thr Ile Gln Glu Ala His Gly Leu Pro Val Met Asp Asp Gln Thr Gln 
            180                 185                 190         


Gly Ser Asp Pro Tyr Ile Lys Met Thr Ile Leu Pro Asp Lys Arg His 
        195                 200                 205             


Arg Val Lys Thr Arg Val Leu Arg Lys Thr Leu Asp Pro Val Phe Asp 
    210                 215                 220                 


Glu Thr Phe Thr Phe Tyr Gly Ile Pro Tyr Ser Gln Leu Gln Asp Leu 
225                 230                 235                 240 


Val Leu His Phe Leu Val Leu Ser Phe Asp Arg Phe Ser Arg Asp Asp 
                245                 250                 255     


Val Ile Gly Glu Val Met Val Pro Leu Ala Gly Val Asp Pro Ser Thr 
            260                 265                 270         


Gly Lys Val Gln Leu Thr Arg Asp Ile Ile Lys Arg Asn Ile Gln Lys 
        275                 280                 285             


Cys Ile Ser Arg Gly Glu Leu Gln Val Ser Leu Ser Tyr Gln Pro Val 
    290                 295                 300                 


Ala Gln Arg Met Thr Val Val Val Leu Lys Ala Arg His Leu Pro Lys 
305                 310                 315                 320 


Met Asp Ile Thr Gly Leu Ser Gly Asn Pro Tyr Val Lys Val Asn Val 
                325                 330                 335     


Tyr Tyr Gly Arg Lys Arg Ile Ala Lys Lys Lys Thr His Val Lys Lys 
            340                 345                 350         


Cys Thr Leu Asn Pro Ile Phe Asn Glu Ser Phe Ile Tyr Asp Ile Pro 
        355                 360                 365             


Thr Asp Leu Leu Pro Asp Ile Ser Ile Glu Phe Leu Val Ile Asp Phe 
    370                 375                 380                 


Asp Arg Thr Thr Lys Asn Glu Val Val Gly Arg Leu Ile Leu Gly Ala 
385                 390                 395                 400 


His Ser Val Thr Ala Ser Gly Ala Glu His Trp Arg Glu Val Cys Glu 
                405                 410                 415     


Ser Pro Arg Lys Pro Val Ala Lys Trp His Ser Leu Ser Glu Tyr 
            420                 425                 430     


<210>  302
<211>  513
<212>  PRT
<213>  Homo sapiens

<400>  302

Met Ser Ser Lys Pro Glu Pro Lys Asp Val His Gln Leu Asn Gly Thr 
1               5                   10                  15      


Gly Pro Ser Ala Ser Pro Cys Ser Ser Asp Gly Pro Gly Arg Glu Pro 
            20                  25                  30          


Leu Ala Gly Thr Ser Glu Phe Leu Gly Pro Asp Gly Ala Gly Val Glu 
        35                  40                  45              


Val Val Ile Glu Ser Arg Ala Asn Ala Lys Gly Val Arg Glu Glu Asp 
    50                  55                  60                  


Ala Leu Leu Glu Asn Gly Ser Gln Ser Asn Glu Ser Asp Asp Val Ser 
65                  70                  75                  80  


Thr Asp Arg Gly Pro Ala Pro Pro Ser Pro Leu Lys Glu Thr Ser Phe 
                85                  90                  95      


Ser Ile Gly Leu Gln Val Leu Phe Pro Phe Leu Leu Ala Gly Phe Gly 
            100                 105                 110         


Thr Val Ala Ala Gly Met Val Leu Asp Ile Val Gln His Trp Glu Val 
        115                 120                 125             


Phe Gln Lys Val Thr Glu Val Phe Ile Leu Val Pro Ala Leu Leu Gly 
    130                 135                 140                 


Leu Lys Gly Asn Leu Glu Met Thr Leu Ala Ser Arg Leu Ser Thr Ala 
145                 150                 155                 160 


Ala Asn Ile Gly His Met Asp Thr Pro Lys Glu Leu Trp Arg Met Ile 
                165                 170                 175     


Thr Gly Asn Met Ala Leu Ile Gln Val Gln Ala Thr Val Val Gly Phe 
            180                 185                 190         


Leu Ala Ser Ile Ala Ala Val Val Phe Gly Trp Ile Pro Asp Gly His 
        195                 200                 205             


Phe Ser Ile Pro His Ala Phe Leu Leu Cys Ala Ser Ser Val Ala Thr 
    210                 215                 220                 


Ala Phe Ile Ala Ser Leu Val Leu Gly Met Ile Met Ile Gly Val Ile 
225                 230                 235                 240 


Ile Gly Ser Arg Lys Ile Gly Ile Asn Pro Asp Asn Val Ala Thr Pro 
                245                 250                 255     


Ile Ala Ala Ser Leu Gly Asp Leu Ile Thr Leu Ala Leu Leu Ser Gly 
            260                 265                 270         


Ile Ser Trp Gly Leu Tyr Leu Glu Leu Asn His Trp Arg Tyr Ile Tyr 
        275                 280                 285             


Pro Leu Val Cys Ala Phe Phe Val Ala Leu Leu Pro Val Trp Val Val 
    290                 295                 300                 


Leu Ala Arg Arg Ser Pro Ala Thr Arg Glu Val Leu Tyr Ser Gly Trp 
305                 310                 315                 320 


Glu Pro Val Ile Ile Ala Met Ala Ile Ser Ser Val Gly Gly Leu Ile 
                325                 330                 335     


Leu Asp Lys Thr Val Ser Asp Pro Asn Phe Ala Gly Met Ala Val Phe 
            340                 345                 350         


Thr Pro Val Ile Asn Gly Val Gly Gly Asn Leu Val Ala Val Gln Ala 
        355                 360                 365             


Ser Arg Ile Ser Thr Phe Leu His Met Asn Gly Met Pro Gly Glu Asn 
    370                 375                 380                 


Ser Glu Gln Ala Pro Arg Arg Cys Pro Ser Pro Cys Thr Thr Phe Phe 
385                 390                 395                 400 


Ser Pro Asp Val Asn Ser Arg Ser Ala Arg Val Leu Phe Leu Leu Val 
                405                 410                 415     


Val Pro Gly His Leu Val Phe Leu Tyr Thr Ile Ser Cys Met Gln Gly 
            420                 425                 430         


Gly His Thr Thr Leu Thr Leu Ile Phe Ile Ile Phe Tyr Met Thr Ala 
        435                 440                 445             


Ala Leu Leu Gln Val Leu Ile Leu Leu Tyr Ile Ala Asp Trp Met Val 
    450                 455                 460                 


His Trp Met Trp Gly Arg Gly Leu Asp Pro Asp Asn Phe Ser Ile Pro 
465                 470                 475                 480 


Tyr Leu Thr Ala Leu Gly Asp Leu Leu Gly Thr Gly Leu Leu Ala Leu 
                485                 490                 495     


Ser Phe His Val Leu Trp Leu Ile Gly Asp Arg Asp Thr Asp Val Gly 
            500                 505                 510         


Asp 
    


<210>  303
<211>  1226
<212>  PRT
<213>  Homo sapiens

<400>  303

Met Asp Arg Glu Glu Arg Lys Thr Ile Asn Gln Gly Gln Glu Asp Glu 
1               5                   10                  15      


Met Glu Ile Tyr Gly Tyr Asn Leu Ser Arg Trp Lys Leu Ala Ile Val 
            20                  25                  30          


Ser Leu Gly Val Ile Cys Ser Gly Gly Phe Leu Leu Leu Leu Leu Tyr 
        35                  40                  45              


Trp Met Pro Glu Trp Arg Val Lys Ala Thr Cys Val Arg Ala Ala Ile 
    50                  55                  60                  


Lys Asp Cys Glu Val Val Leu Leu Arg Thr Thr Asp Glu Phe Lys Met 
65                  70                  75                  80  


Trp Phe Cys Ala Lys Ile Arg Val Leu Ser Leu Glu Thr Tyr Pro Val 
                85                  90                  95      


Ser Ser Pro Lys Ser Met Ser Asn Lys Leu Ser Asn Gly His Ala Val 
            100                 105                 110         


Cys Leu Ile Glu Asn Pro Thr Glu Glu Asn Arg His Arg Ile Ser Lys 
        115                 120                 125             


Tyr Ser Gln Thr Glu Ser Gln Gln Ile Arg Tyr Phe Thr His His Ser 
    130                 135                 140                 


Val Lys Tyr Phe Trp Asn Asp Thr Ile His Asn Phe Asp Phe Leu Lys 
145                 150                 155                 160 


Gly Leu Asp Glu Gly Val Ser Cys Thr Ser Ile Tyr Glu Lys His Ser 
                165                 170                 175     


Ala Gly Leu Thr Lys Gly Met His Ala Tyr Arg Lys Leu Leu Tyr Gly 
            180                 185                 190         


Val Asn Glu Ile Ala Val Lys Val Pro Ser Val Phe Lys Leu Leu Ile 
        195                 200                 205             


Lys Glu Val Leu Asn Pro Phe Tyr Ile Phe Gln Leu Phe Ser Val Ile 
    210                 215                 220                 


Leu Trp Ser Thr Asp Glu Tyr Tyr Tyr Tyr Ala Leu Ala Ile Val Val 
225                 230                 235                 240 


Met Ser Ile Val Ser Ile Val Ser Ser Leu Tyr Ser Ile Arg Lys Gln 
                245                 250                 255     


Tyr Val Met Leu His Asp Met Val Ala Thr His Ser Thr Val Arg Val 
            260                 265                 270         


Ser Val Cys Arg Val Asn Glu Glu Ile Glu Glu Ile Phe Ser Thr Asp 
        275                 280                 285             


Leu Val Pro Gly Asp Val Met Val Ile Pro Leu Asn Gly Thr Ile Met 
    290                 295                 300                 


Pro Cys Asp Ala Val Leu Ile Asn Gly Thr Cys Ile Val Asn Glu Ser 
305                 310                 315                 320 


Met Leu Thr Gly Glu Ser Val Pro Val Thr Lys Thr Asn Leu Pro Asn 
                325                 330                 335     


Pro Ser Val Asp Val Lys Gly Ile Gly Asp Glu Leu Tyr Asn Pro Glu 
            340                 345                 350         


Thr His Lys Arg His Thr Leu Phe Cys Gly Thr Thr Val Ile Gln Thr 
        355                 360                 365             


Arg Phe Tyr Thr Gly Glu Leu Val Lys Ala Ile Val Val Arg Thr Gly 
    370                 375                 380                 


Phe Ser Thr Ser Lys Gly Gln Leu Val Arg Ser Ile Leu Tyr Pro Lys 
385                 390                 395                 400 


Pro Thr Asp Phe Lys Leu Tyr Arg Asp Ala Tyr Leu Phe Leu Leu Cys 
                405                 410                 415     


Leu Val Ala Val Ala Gly Ile Gly Phe Ile Tyr Thr Ile Ile Asn Ser 
            420                 425                 430         


Ile Leu Asn Glu Val Gln Val Gly Val Ile Ile Ile Glu Ser Leu Asp 
        435                 440                 445             


Ile Ile Thr Ile Thr Val Pro Pro Ala Leu Pro Ala Ala Met Thr Ala 
    450                 455                 460                 


Gly Ile Val Tyr Ala Gln Arg Arg Leu Lys Lys Ile Gly Ile Phe Cys 
465                 470                 475                 480 


Ile Ser Pro Gln Arg Ile Asn Ile Cys Gly Gln Leu Asn Leu Val Cys 
                485                 490                 495     


Phe Asp Lys Thr Gly Thr Leu Thr Glu Asp Gly Leu Asp Leu Trp Gly 
            500                 505                 510         


Ile Gln Arg Val Glu Asn Ala Arg Phe Leu Ser Pro Glu Glu Asn Val 
        515                 520                 525             


Cys Asn Glu Met Leu Val Lys Ser Gln Phe Val Ala Cys Met Ala Thr 
    530                 535                 540                 


Cys His Ser Leu Thr Lys Ile Glu Gly Val Leu Ser Gly Asp Pro Leu 
545                 550                 555                 560 


Asp Leu Lys Met Phe Glu Ala Ile Gly Trp Ile Leu Glu Glu Ala Thr 
                565                 570                 575     


Glu Glu Glu Thr Ala Leu His Asn Arg Ile Met Pro Thr Val Val Arg 
            580                 585                 590         


Pro Pro Lys Gln Leu Leu Pro Glu Ser Thr Pro Ala Gly Asn Gln Glu 
        595                 600                 605             


Met Glu Leu Phe Glu Leu Pro Ala Thr Tyr Glu Ile Gly Ile Val Arg 
    610                 615                 620                 


Gln Phe Pro Phe Ser Ser Ala Leu Gln Arg Met Ser Val Val Ala Arg 
625                 630                 635                 640 


Val Leu Gly Asp Arg Lys Met Asp Ala Tyr Met Lys Gly Ala Pro Glu 
                645                 650                 655     


Ala Ile Ala Gly Leu Cys Lys Pro Glu Thr Val Pro Val Asp Phe Gln 
            660                 665                 670         


Asn Val Leu Glu Asp Phe Thr Lys Gln Gly Phe Arg Val Ile Ala Leu 
        675                 680                 685             


Ala His Arg Lys Leu Glu Ser Lys Leu Thr Trp His Lys Val Gln Asn 
    690                 695                 700                 


Ile Ser Arg Asp Ala Ile Glu Asn Asn Met Asp Phe Met Gly Leu Ile 
705                 710                 715                 720 


Ile Met Gln Asn Lys Leu Lys Gln Glu Thr Pro Ala Val Leu Glu Asp 
                725                 730                 735     


Leu His Lys Ala Asn Ile Arg Thr Val Met Val Thr Gly Asp Ser Met 
            740                 745                 750         


Leu Thr Ala Val Ser Val Ala Arg Asp Cys Gly Met Ile Leu Pro Gln 
        755                 760                 765             


Asp Lys Val Ile Ile Ala Glu Ala Leu Pro Pro Lys Asp Gly Lys Val 
    770                 775                 780                 


Ala Lys Ile Asn Trp His Tyr Ala Asp Ser Leu Thr Gln Cys Ser His 
785                 790                 795                 800 


Pro Ser Ala Ile Asp Pro Glu Ala Ile Pro Val Lys Leu Val His Asp 
                805                 810                 815     


Ser Leu Glu Asp Leu Gln Met Thr Arg Tyr His Phe Ala Met Asn Gly 
            820                 825                 830         


Lys Ser Phe Ser Val Ile Leu Glu His Phe Gln Asp Leu Val Pro Lys 
        835                 840                 845             


Leu Met Leu His Gly Thr Val Phe Ala Arg Met Ala Pro Asp Gln Lys 
    850                 855                 860                 


Thr Gln Leu Ile Glu Ala Leu Gln Asn Val Asp Tyr Phe Val Gly Met 
865                 870                 875                 880 


Cys Gly Asp Gly Ala Asn Asp Cys Gly Ala Leu Lys Arg Ala His Gly 
                885                 890                 895     


Gly Ile Ser Leu Ser Glu Leu Glu Ala Ser Val Ala Ser Pro Phe Thr 
            900                 905                 910         


Ser Lys Thr Pro Ser Ile Ser Cys Val Pro Asn Leu Ile Arg Glu Gly 
        915                 920                 925             


Arg Ala Ala Leu Ile Thr Ser Phe Cys Val Phe Lys Phe Met Ala Leu 
    930                 935                 940                 


Tyr Ser Ile Ile Gln Tyr Phe Ser Val Thr Leu Leu Tyr Ser Ile Leu 
945                 950                 955                 960 


Ser Asn Leu Gly Asp Phe Gln Phe Leu Phe Ile Asp Leu Ala Ile Ile 
                965                 970                 975     


Leu Val Val Val Phe Thr Met Ser Leu Asn Pro Ala Trp Lys Glu Leu 
            980                 985                 990         


Val Ala Gln Arg Pro Pro Ser Gly  Leu Ile Ser Gly Ala  Leu Leu Phe 
        995                 1000                 1005             


Ser Val  Leu Ser Gln Ile Ile  Ile Cys Ile Gly Phe  Gln Ser Leu 
    1010                 1015                 1020             


Gly Phe  Phe Trp Val Lys Gln  Gln Pro Trp Tyr Glu  Val Trp His 
    1025                 1030                 1035             


Pro Lys  Ser Asp Ala Cys Asn  Thr Thr Gly Ser Gly  Phe Trp Asn 
    1040                 1045                 1050             


Ser Ser  His Val Asp Asn Glu  Thr Glu Leu Asp Glu  His Asn Ile 
    1055                 1060                 1065             


Gln Asn  Tyr Glu Asn Thr Thr  Val Phe Phe Ile Ser  Ser Phe Gln 
    1070                 1075                 1080             


Tyr Leu  Ile Val Ala Ile Ala  Phe Ser Lys Gly Lys  Pro Phe Arg 
    1085                 1090                 1095             


Gln Pro  Cys Tyr Lys Asn Tyr  Phe Phe Val Phe Ser  Val Ile Phe 
    1100                 1105                 1110             


Leu Tyr  Ile Phe Ile Leu Phe  Ile Met Leu Tyr Pro  Val Ala Ser 
    1115                 1120                 1125             


Val Asp  Gln Val Leu Gln Ile  Val Cys Val Pro Tyr  Gln Trp Arg 
    1130                 1135                 1140             


Val Thr  Met Leu Ile Ile Val  Leu Val Asn Ala Phe  Val Ser Ile 
    1145                 1150                 1155             


Thr Val  Glu Glu Ser Val Asp  Arg Trp Gly Lys Cys  Cys Leu Pro 
    1160                 1165                 1170             


Trp Ala  Leu Gly Cys Arg Lys  Lys Thr Pro Lys Ala  Lys Tyr Met 
    1175                 1180                 1185             


Tyr Leu  Ala Gln Glu Leu Leu  Val Asp Pro Glu Trp  Pro Pro Lys 
    1190                 1195                 1200             


Pro Gln  Thr Thr Thr Glu Ala  Lys Ala Leu Val Lys  Glu Asn Gly 
    1205                 1210                 1215             


Ser Cys  Gln Ile Ile Thr Ile  Thr 
    1220                 1225     


<210>  304
<211>  162
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  304

Xaa Pro Phe Arg Gln Pro Cys Tyr Lys Asn Tyr Phe Phe Val Phe Ser 
1               5                   10                  15      


Val Ile Phe Leu Tyr Ile Phe Ile Leu Phe Ile Met Leu Tyr Pro Val 
            20                  25                  30          


Ala Ser Val Asp Gln Val Leu Gln Ile Val Cys Val Pro Tyr Gln Trp 
        35                  40                  45              


Arg Val Thr Met Leu Ile Ile Val Leu Val Asn Ala Phe Val Ser Ile 
    50                  55                  60                  


Thr Val Glu Asn Phe Phe Leu Asp Met Val Leu Trp Lys Val Val Phe 
65                  70                  75                  80  


Asn Arg Asp Lys Gln Gly Glu Tyr Arg Phe Ser Thr Thr Gln Pro Pro 
                85                  90                  95      


Gln Glu Ser Val Asp Arg Trp Gly Lys Cys Cys Leu Pro Trp Ala Leu 
            100                 105                 110         


Gly Cys Arg Lys Lys Thr Pro Lys Ala Lys Tyr Met Tyr Leu Ala Gln 
        115                 120                 125             


Glu Leu Leu Val Asp Pro Glu Trp Pro Pro Lys Pro Gln Thr Thr Thr 
    130                 135                 140                 


Glu Ala Lys Ala Leu Val Lys Glu Asn Gly Ser Cys Gln Ile Ile Thr 
145                 150                 155                 160 


Ile Thr 
        


<210>  305
<211>  1226
<212>  PRT
<213>  Homo sapiens

<400>  305

Met Asp Arg Glu Glu Arg Lys Thr Ile Asn Gln Gly Gln Glu Asp Glu 
1               5                   10                  15      


Met Glu Ile Tyr Gly Tyr Asn Leu Ser Arg Trp Lys Leu Ala Ile Val 
            20                  25                  30          


Ser Leu Gly Val Ile Cys Ser Gly Gly Phe Leu Leu Leu Leu Leu Tyr 
        35                  40                  45              


Trp Met Pro Glu Trp Arg Val Lys Ala Thr Cys Val Arg Ala Ala Ile 
    50                  55                  60                  


Lys Asp Cys Glu Val Val Leu Leu Arg Thr Thr Asp Glu Phe Lys Met 
65                  70                  75                  80  


Trp Phe Cys Ala Lys Ile Arg Val Leu Ser Leu Glu Thr Tyr Pro Val 
                85                  90                  95      


Ser Ser Pro Lys Ser Met Ser Asn Lys Leu Ser Asn Gly His Ala Val 
            100                 105                 110         


Cys Leu Ile Glu Asn Pro Thr Glu Glu Asn Arg His Arg Ile Ser Lys 
        115                 120                 125             


Tyr Ser Gln Thr Glu Ser Gln Gln Ile Arg Tyr Phe Thr His His Ser 
    130                 135                 140                 


Val Lys Tyr Phe Trp Asn Asp Thr Ile His Asn Phe Asp Phe Leu Lys 
145                 150                 155                 160 


Gly Leu Asp Glu Gly Val Ser Cys Thr Ser Ile Tyr Glu Lys His Ser 
                165                 170                 175     


Ala Gly Leu Thr Lys Gly Met His Ala Tyr Arg Lys Leu Leu Tyr Gly 
            180                 185                 190         


Val Asn Glu Ile Ala Val Lys Val Pro Ser Val Phe Lys Leu Leu Ile 
        195                 200                 205             


Lys Glu Val Leu Asn Pro Phe Tyr Ile Phe Gln Leu Phe Ser Val Ile 
    210                 215                 220                 


Leu Trp Ser Thr Asp Glu Tyr Tyr Tyr Tyr Ala Leu Ala Ile Val Val 
225                 230                 235                 240 


Met Ser Ile Val Ser Ile Val Ser Ser Leu Tyr Ser Ile Arg Lys Gln 
                245                 250                 255     


Tyr Val Met Leu His Asp Met Val Ala Thr His Ser Thr Val Arg Val 
            260                 265                 270         


Ser Val Cys Arg Val Asn Glu Glu Ile Glu Glu Ile Phe Ser Thr Asp 
        275                 280                 285             


Leu Val Pro Gly Asp Val Met Val Ile Pro Leu Asn Gly Thr Ile Met 
    290                 295                 300                 


Pro Cys Asp Ala Val Leu Ile Asn Gly Thr Cys Ile Val Asn Glu Ser 
305                 310                 315                 320 


Met Leu Thr Gly Glu Ser Val Pro Val Thr Lys Thr Asn Leu Pro Asn 
                325                 330                 335     


Pro Ser Val Asp Val Lys Gly Ile Gly Asp Glu Leu Tyr Asn Pro Glu 
            340                 345                 350         


Thr His Lys Arg His Thr Leu Phe Cys Gly Thr Thr Val Ile Gln Thr 
        355                 360                 365             


Arg Phe Tyr Thr Gly Glu Leu Val Lys Ala Ile Val Val Arg Thr Gly 
    370                 375                 380                 


Phe Ser Thr Ser Lys Gly Gln Leu Val Arg Ser Ile Leu Tyr Pro Lys 
385                 390                 395                 400 


Pro Thr Asp Phe Lys Leu Tyr Arg Asp Ala Tyr Leu Phe Leu Leu Cys 
                405                 410                 415     


Leu Val Ala Val Ala Gly Ile Gly Phe Ile Tyr Thr Ile Ile Asn Ser 
            420                 425                 430         


Ile Leu Asn Glu Val Gln Val Gly Val Ile Ile Ile Glu Ser Leu Asp 
        435                 440                 445             


Ile Ile Thr Ile Thr Val Pro Pro Ala Leu Pro Ala Ala Met Thr Ala 
    450                 455                 460                 


Gly Ile Val Tyr Ala Gln Arg Arg Leu Lys Lys Ile Gly Ile Phe Cys 
465                 470                 475                 480 


Ile Ser Pro Gln Arg Ile Asn Ile Cys Gly Gln Leu Asn Leu Val Cys 
                485                 490                 495     


Phe Asp Lys Thr Gly Thr Leu Thr Glu Asp Gly Leu Asp Leu Trp Gly 
            500                 505                 510         


Ile Gln Arg Val Glu Asn Ala Arg Phe Leu Ser Pro Glu Glu Asn Val 
        515                 520                 525             


Cys Asn Glu Met Leu Val Lys Ser Gln Phe Val Ala Cys Met Ala Thr 
    530                 535                 540                 


Cys His Ser Leu Thr Lys Ile Glu Gly Val Leu Ser Gly Asp Pro Leu 
545                 550                 555                 560 


Asp Leu Lys Met Phe Glu Ala Ile Gly Trp Ile Leu Glu Glu Ala Thr 
                565                 570                 575     


Glu Glu Glu Thr Ala Leu His Asn Arg Ile Met Pro Thr Val Val Arg 
            580                 585                 590         


Pro Pro Lys Gln Leu Leu Pro Glu Ser Thr Pro Ala Gly Asn Gln Glu 
        595                 600                 605             


Met Glu Leu Phe Glu Leu Pro Ala Thr Tyr Glu Ile Gly Ile Val Arg 
    610                 615                 620                 


Gln Phe Pro Phe Ser Ser Ala Leu Gln Arg Met Ser Val Val Ala Arg 
625                 630                 635                 640 


Val Leu Gly Asp Arg Lys Met Asp Ala Tyr Met Lys Gly Ala Pro Glu 
                645                 650                 655     


Ala Ile Ala Gly Leu Cys Lys Pro Glu Thr Val Pro Val Asp Phe Gln 
            660                 665                 670         


Asn Val Leu Glu Asp Phe Thr Lys Gln Gly Phe Arg Val Ile Ala Leu 
        675                 680                 685             


Ala His Arg Lys Leu Glu Ser Lys Leu Thr Trp His Lys Val Gln Asn 
    690                 695                 700                 


Ile Ser Arg Asp Ala Ile Glu Asn Asn Met Asp Phe Met Gly Leu Ile 
705                 710                 715                 720 


Ile Met Gln Asn Lys Leu Lys Gln Glu Thr Pro Ala Val Leu Glu Asp 
                725                 730                 735     


Leu His Lys Ala Asn Ile Arg Thr Val Met Val Thr Gly Asp Ser Met 
            740                 745                 750         


Leu Thr Ala Val Ser Val Ala Arg Asp Cys Gly Met Ile Leu Pro Gln 
        755                 760                 765             


Asp Lys Val Ile Ile Ala Glu Ala Leu Pro Pro Lys Asp Gly Lys Val 
    770                 775                 780                 


Ala Lys Ile Asn Trp His Tyr Ala Asp Ser Leu Thr Gln Cys Ser His 
785                 790                 795                 800 


Pro Ser Ala Ile Asp Pro Glu Ala Ile Pro Val Lys Leu Val His Asp 
                805                 810                 815     


Ser Leu Glu Asp Leu Gln Met Thr Arg Tyr His Phe Ala Met Asn Gly 
            820                 825                 830         


Lys Ser Phe Ser Val Ile Leu Glu His Phe Gln Asp Leu Val Pro Lys 
        835                 840                 845             


Leu Met Leu His Gly Thr Val Phe Ala Arg Met Ala Pro Asp Gln Lys 
    850                 855                 860                 


Thr Gln Leu Ile Glu Ala Leu Gln Asn Val Asp Tyr Phe Val Gly Met 
865                 870                 875                 880 


Cys Gly Asp Gly Ala Asn Asp Cys Gly Ala Leu Lys Arg Ala His Gly 
                885                 890                 895     


Gly Ile Ser Leu Ser Glu Leu Glu Ala Ser Val Ala Ser Pro Phe Thr 
            900                 905                 910         


Ser Lys Thr Pro Ser Ile Ser Cys Val Pro Asn Leu Ile Arg Glu Gly 
        915                 920                 925             


Arg Ala Ala Leu Ile Thr Ser Phe Cys Val Phe Lys Phe Met Ala Leu 
    930                 935                 940                 


Tyr Ser Ile Ile Gln Tyr Phe Ser Val Thr Leu Leu Tyr Ser Ile Leu 
945                 950                 955                 960 


Ser Asn Leu Gly Asp Phe Gln Phe Leu Phe Ile Asp Leu Ala Ile Ile 
                965                 970                 975     


Leu Val Val Val Phe Thr Met Ser Leu Asn Pro Ala Trp Lys Glu Leu 
            980                 985                 990         


Val Ala Gln Arg Pro Pro Ser Gly  Leu Ile Ser Gly Ala  Leu Leu Phe 
        995                 1000                 1005             


Ser Val  Leu Ser Gln Ile Ile  Ile Cys Ile Gly Phe  Gln Ser Leu 
    1010                 1015                 1020             


Gly Phe  Phe Trp Val Lys Gln  Gln Pro Trp Tyr Glu  Val Trp His 
    1025                 1030                 1035             


Pro Lys  Ser Asp Ala Cys Asn  Thr Thr Gly Ser Gly  Phe Trp Asn 
    1040                 1045                 1050             


Ser Ser  His Val Asp Asn Glu  Thr Glu Leu Asp Glu  His Asn Ile 
    1055                 1060                 1065             


Gln Asn  Tyr Glu Asn Thr Thr  Val Phe Phe Ile Ser  Ser Phe Gln 
    1070                 1075                 1080             


Tyr Leu  Ile Val Ala Ile Ala  Phe Ser Lys Gly Lys  Pro Phe Arg 
    1085                 1090                 1095             


Gln Pro  Cys Tyr Lys Asn Tyr  Phe Phe Val Phe Ser  Val Ile Phe 
    1100                 1105                 1110             


Leu Tyr  Ile Phe Ile Leu Phe  Ile Met Leu Tyr Pro  Val Ala Ser 
    1115                 1120                 1125             


Val Asp  Gln Val Leu Gln Ile  Val Cys Val Pro Tyr  Gln Trp Arg 
    1130                 1135                 1140             


Val Thr  Met Leu Ile Ile Val  Leu Val Asn Ala Phe  Val Ser Ile 
    1145                 1150                 1155             


Thr Val  Glu Glu Ser Val Asp  Arg Trp Gly Lys Cys  Cys Leu Pro 
    1160                 1165                 1170             


Trp Ala  Leu Gly Cys Arg Lys  Lys Thr Pro Lys Ala  Lys Tyr Met 
    1175                 1180                 1185             


Tyr Leu  Ala Gln Glu Leu Leu  Val Asp Pro Glu Trp  Pro Pro Lys 
    1190                 1195                 1200             


Pro Gln  Thr Thr Thr Glu Ala  Lys Ala Leu Val Lys  Glu Asn Gly 
    1205                 1210                 1215             


Ser Cys  Gln Ile Ile Thr Ile  Thr 
    1220                 1225     


<210>  306
<211>  47
<212>  PRT
<213>  Homo sapiens

<400>  306

Met Asp Arg Glu Glu Arg Lys Thr Ile Asn Gln Gly Gln Glu Asp Glu 
1               5                   10                  15      


Met Glu Ile Tyr Gly Tyr Asn Leu Ser Arg Trp Lys Leu Ala Ile Val 
            20                  25                  30          


Ser Leu Gly Val Ile Cys Ser Gly Gly Phe Leu Leu Leu Leu Leu 
        35                  40                  45          


<210>  307
<211>  103
<212>  PRT
<213>  Homo sapiens

<400>  307

Met Asp Arg Glu Glu Arg Lys Thr Ile Asn Gln Gly Gln Glu Asp Glu 
1               5                   10                  15      


Met Glu Ile Tyr Gly Tyr Asn Leu Ser Arg Trp Lys Leu Ala Ile Val 
            20                  25                  30          


Ser Leu Gly Val Ile Cys Ser Gly Gly Phe Leu Leu Leu Leu Leu Tyr 
        35                  40                  45              


Trp Met Pro Glu Trp Arg Val Lys Ala Thr Cys Val Arg Ala Ala Ile 
    50                  55                  60                  


Lys Asp Cys Glu Val Val Leu Leu Arg Thr Thr Asp Glu Phe Lys Met 
65                  70                  75                  80  


Trp Phe Cys Ala Lys Ile Arg Val Leu Ser Leu Glu Thr Tyr Pro Val 
                85                  90                  95      


Ser Ser Pro Lys Ser Met Ser 
            100             


<210>  308
<211>  701
<212>  PRT
<213>  Homo sapiens

<400>  308

Ile Ser Glu Ile Glu Glu Ile Phe Ser Thr Asp Leu Val Pro Gly Asp 
1               5                   10                  15      


Val Met Val Ile Pro Leu Asn Gly Thr Ile Met Pro Cys Asp Ala Val 
            20                  25                  30          


Leu Ile Asn Gly Thr Cys Ile Val Asn Glu Ser Met Leu Thr Gly Glu 
        35                  40                  45              


Ser Val Pro Val Thr Lys Thr Asn Leu Pro Asn Pro Ser Val Asp Val 
    50                  55                  60                  


Lys Gly Ile Gly Asp Glu Leu Tyr Asn Pro Glu Thr His Lys Arg His 
65                  70                  75                  80  


Thr Leu Phe Cys Gly Thr Thr Val Ile Gln Thr Arg Phe Tyr Thr Gly 
                85                  90                  95      


Glu Leu Val Lys Ala Ile Val Val Arg Thr Gly Phe Ser Thr Ser Lys 
            100                 105                 110         


Gly Gln Leu Val Arg Ser Ile Leu Tyr Pro Lys Pro Thr Asp Phe Lys 
        115                 120                 125             


Leu Tyr Arg Asp Ala Tyr Leu Phe Leu Leu Cys Leu Val Ala Val Ala 
    130                 135                 140                 


Gly Ile Gly Phe Ile Tyr Thr Ile Ile Asn Ser Ile Leu Asn Glu Val 
145                 150                 155                 160 


Gln Val Gly Val Ile Ile Ile Glu Ser Leu Asp Ile Ile Thr Ile Thr 
                165                 170                 175     


Val Pro Pro Ala Leu Pro Ala Ala Met Thr Ala Gly Ile Val Tyr Ala 
            180                 185                 190         


Gln Arg Arg Leu Lys Lys Ile Gly Ile Phe Cys Ile Ser Pro Gln Arg 
        195                 200                 205             


Ile Asn Ile Cys Gly Gln Leu Asn Leu Val Cys Phe Asp Lys Thr Gly 
    210                 215                 220                 


Thr Leu Thr Glu Asp Gly Leu Asp Leu Trp Gly Ile Gln Arg Val Glu 
225                 230                 235                 240 


Asn Ala Arg Phe Leu Ser Pro Glu Glu Asn Val Cys Asn Glu Met Leu 
                245                 250                 255     


Val Lys Ser Gln Phe Val Ala Cys Met Ala Thr Cys His Ser Leu Thr 
            260                 265                 270         


Lys Ile Glu Gly Val Leu Ser Gly Asp Pro Leu Asp Leu Lys Met Phe 
        275                 280                 285             


Glu Ala Ile Gly Trp Ile Leu Glu Glu Ala Thr Glu Glu Glu Thr Ala 
    290                 295                 300                 


Leu His Asn Arg Ile Met Pro Thr Val Val Arg Pro Pro Lys Gln Leu 
305                 310                 315                 320 


Leu Pro Glu Ser Thr Pro Ala Gly Asn Gln Glu Met Glu Leu Phe Glu 
                325                 330                 335     


Leu Pro Ala Thr Tyr Glu Ile Gly Ile Val Arg Gln Phe Pro Phe Ser 
            340                 345                 350         


Ser Ala Leu Gln Arg Met Ser Val Val Ala Arg Val Leu Gly Asp Arg 
        355                 360                 365             


Lys Met Asp Ala Tyr Met Lys Gly Ala Pro Glu Ala Ile Ala Gly Leu 
    370                 375                 380                 


Cys Lys Pro Glu Thr Val Pro Val Asp Phe Gln Asn Val Leu Glu Asp 
385                 390                 395                 400 


Phe Thr Lys Gln Gly Phe Arg Val Ile Ala Leu Ala His Arg Lys Leu 
                405                 410                 415     


Glu Ser Lys Leu Thr Trp His Lys Val Gln Asn Ile Ser Arg Asp Ala 
            420                 425                 430         


Ile Glu Asn Asn Met Asp Phe Met Gly Leu Ile Ile Met Gln Asn Lys 
        435                 440                 445             


Leu Lys Gln Glu Thr Pro Ala Val Leu Glu Asp Leu His Lys Ala Asn 
    450                 455                 460                 


Ile Arg Thr Val Met Val Thr Gly Asp Ser Met Leu Thr Ala Val Ser 
465                 470                 475                 480 


Val Ala Arg Asp Cys Gly Met Ile Leu Pro Gln Asp Lys Val Ile Ile 
                485                 490                 495     


Ala Glu Ala Leu Pro Pro Lys Asp Gly Lys Val Ala Lys Ile Asn Trp 
            500                 505                 510         


His Tyr Ala Asp Ser Leu Thr Gln Cys Ser His Pro Ser Ala Ile Asp 
        515                 520                 525             


Pro Glu Ala Ile Pro Val Lys Leu Val His Asp Ser Leu Glu Asp Leu 
    530                 535                 540                 


Gln Met Thr Arg Tyr His Phe Ala Met Asn Gly Lys Ser Phe Ser Val 
545                 550                 555                 560 


Ile Leu Glu His Phe Gln Asp Leu Val Pro Lys Leu Met Leu His Gly 
                565                 570                 575     


Thr Val Phe Ala Arg Met Ala Pro Asp Gln Lys Thr Gln Leu Ile Glu 
            580                 585                 590         


Ala Leu Gln Asn Val Asp Tyr Phe Val Gly Met Cys Gly Asp Gly Ala 
        595                 600                 605             


Asn Asp Cys Gly Ala Leu Lys Arg Ala His Gly Gly Ile Ser Leu Ser 
    610                 615                 620                 


Glu Leu Glu Ala Ser Val Ala Ser Pro Phe Thr Ser Lys Thr Pro Ser 
625                 630                 635                 640 


Ile Ser Cys Val Pro Asn Leu Ile Arg Glu Gly Arg Ala Ala Leu Ile 
                645                 650                 655     


Thr Ser Phe Cys Glu Leu Ala Leu Phe Ser Ile Val Thr Tyr Ser Leu 
            660                 665                 670         


Asp His Phe Ile Ile Ser Ile Leu Ile Ser Asn Met Leu Val Leu Phe 
        675                 680                 685             


Phe Ser Asp Phe His Asn Cys Ala Phe Tyr Ser Leu Val 
    690                 695                 700     


<210>  309
<211>  976
<212>  PRT
<213>  Homo sapiens

<400>  309

Met Gly Glu Asn Glu Asp Glu Lys Gln Ala Gln Ala Gly Gln Val Phe 
1               5                   10                  15      


Glu Asn Phe Val Gln Ala Ser Thr Cys Lys Gly Thr Leu Gln Ala Phe 
            20                  25                  30          


Asn Ile Leu Thr Arg His Leu Asp Leu Asp Pro Leu Asp His Arg Asn 
        35                  40                  45              


Phe Tyr Ser Lys Leu Lys Ser Lys Val Thr Thr Trp Lys Ala Lys Ala 
    50                  55                  60                  


Leu Trp Tyr Lys Leu Asp Lys Arg Gly Ser His Lys Glu Tyr Lys Arg 
65                  70                  75                  80  


Gly Lys Ser Cys Thr Asn Thr Lys Cys Leu Ile Val Gly Gly Gly Pro 
                85                  90                  95      


Cys Gly Leu Arg Thr Ala Ile Glu Leu Ala Tyr Leu Gly Ala Lys Val 
            100                 105                 110         


Val Val Val Glu Lys Arg Asp Ser Phe Ser Arg Asn Asn Val Leu His 
        115                 120                 125             


Leu Trp Pro Phe Thr Ile His Asp Leu Arg Gly Leu Gly Ala Lys Lys 
    130                 135                 140                 


Phe Tyr Gly Lys Phe Cys Ala Gly Ser Ile Asp His Ile Ser Ile Arg 
145                 150                 155                 160 


Gln Leu Gln Leu Ile Leu Phe Lys Val Ala Leu Met Leu Gly Val Glu 
                165                 170                 175     


Ile His Val Asn Val Glu Phe Val Lys Val Leu Glu Pro Pro Glu Asp 
            180                 185                 190         


Gln Glu Asn Gln Lys Ile Gly Trp Arg Ala Glu Phe Leu Pro Thr Asp 
        195                 200                 205             


His Ser Leu Ser Glu Phe Glu Phe Asp Val Ile Ile Gly Ala Asp Gly 
    210                 215                 220                 


Arg Arg Asn Thr Leu Glu Gly Phe Arg Arg Lys Glu Phe Arg Gly Lys 
225                 230                 235                 240 


Leu Ala Ile Ala Ile Thr Ala Asn Phe Ile Asn Arg Asn Ser Thr Ala 
                245                 250                 255     


Glu Ala Lys Val Glu Glu Ile Ser Gly Val Ala Phe Ile Phe Asn Gln 
            260                 265                 270         


Lys Phe Phe Gln Asp Leu Lys Glu Glu Thr Gly Ile Asp Leu Glu Asn 
        275                 280                 285             


Ile Val Tyr Tyr Lys Asp Cys Thr His Tyr Phe Val Met Thr Ala Lys 
    290                 295                 300                 


Lys Gln Ser Leu Leu Asp Lys Gly Val Ile Ile Asn Asp Tyr Ile Asp 
305                 310                 315                 320 


Thr Glu Met Leu Leu Cys Ala Glu Asn Val Asn Gln Asp Asn Leu Leu 
                325                 330                 335     


Ser Tyr Ala Arg Glu Ala Ala Asp Phe Ala Thr Asn Tyr Gln Leu Pro 
            340                 345                 350         


Ser Leu Asp Phe Ala Met Asn His Tyr Gly Gln Pro Asp Val Ala Met 
        355                 360                 365             


Phe Asp Phe Thr Cys Met Tyr Ala Ser Glu Asn Ala Ala Leu Val Arg 
    370                 375                 380                 


Glu Arg Gln Ala His Gln Leu Leu Val Ala Leu Val Gly Asp Ser Leu 
385                 390                 395                 400 


Leu Glu Pro Phe Trp Pro Met Gly Thr Gly Cys Ala Arg Gly Phe Leu 
                405                 410                 415     


Ala Ala Phe Asp Thr Ala Trp Met Val Lys Ser Trp Asn Gln Gly Thr 
            420                 425                 430         


Pro Pro Leu Glu Leu Leu Ala Glu Arg Glu Ser Leu Tyr Arg Leu Leu 
        435                 440                 445             


Pro Gln Thr Thr Pro Glu Asn Ile Asn Lys Asn Phe Glu Gln Tyr Thr 
    450                 455                 460                 


Leu Asp Pro Gly Thr Arg Tyr Pro Asn Leu Asn Ser His Cys Val Arg 
465                 470                 475                 480 


Pro His Gln Val Lys His Leu Tyr Ile Thr Lys Glu Leu Glu His Tyr 
                485                 490                 495     


Pro Leu Glu Arg Leu Gly Ser Val Arg Arg Ser Val Asn Leu Ser Arg 
            500                 505                 510         


Lys Glu Ser Asp Ile Arg Pro Ser Lys Leu Leu Thr Trp Cys Gln Gln 
        515                 520                 525             


Gln Thr Glu Gly Tyr Gln His Val Asn Val Thr Asp Leu Thr Thr Ser 
    530                 535                 540                 


Trp Arg Ser Gly Leu Ala Leu Cys Ala Ile Ile His Arg Phe Arg Pro 
545                 550                 555                 560 


Glu Leu Ile Asn Phe Asp Ser Leu Asn Glu Asp Asp Ala Val Glu Asn 
                565                 570                 575     


Asn Gln Leu Ala Phe Asp Val Ala Glu Arg Glu Phe Gly Ile Pro Pro 
            580                 585                 590         


Val Thr Thr Gly Lys Glu Met Ala Ser Ala Gln Glu Pro Asp Lys Leu 
        595                 600                 605             


Ser Met Val Met Tyr Leu Ser Lys Phe Tyr Glu Leu Phe Arg Gly Thr 
    610                 615                 620                 


Pro Leu Arg Pro Val Asp Ser Trp Arg Lys Asn Tyr Gly Glu Asn Ala 
625                 630                 635                 640 


Asp Leu Ser Leu Ala Lys Ser Ser Ile Ser Asn Asn Tyr Leu Asn Leu 
                645                 650                 655     


Thr Phe Pro Arg Lys Arg Thr Pro Arg Val Asp Gly Gln Thr Gly Glu 
            660                 665                 670         


Asn Asp Met Asn Lys Arg Arg Arg Lys Gly Phe Thr Asn Leu Asp Glu 
        675                 680                 685             


Pro Ser Asn Phe Ser Ser Arg Ser Leu Gly Ser Asn Gln Glu Cys Gly 
    690                 695                 700                 


Ser Ser Lys Glu Gly Gly Asn Gln Asn Lys Val Lys Ser Met Ala Asn 
705                 710                 715                 720 


Gln Leu Leu Ala Lys Phe Glu Glu Ser Thr Arg Asn Pro Ser Leu Met 
                725                 730                 735     


Lys Gln Glu Lys Lys Ser Pro Ser Gly Phe His Phe His Pro Ser His 
            740                 745                 750         


Leu Arg Thr Val His Pro Gln Glu Ser Met Arg Lys Ser Phe Pro Leu 
        755                 760                 765             


Asn Leu Gly Gly Ser Asp Thr Cys Tyr Phe Cys Lys Lys Arg Val Tyr 
    770                 775                 780                 


Val Met Glu Arg Leu Ser Ala Glu Gly His Phe Phe His Arg Glu Cys 
785                 790                 795                 800 


Phe Arg Cys Ser Ile Cys Ala Thr Thr Leu Arg Leu Ala Ala Tyr Thr 
                805                 810                 815     


Phe Asp Cys Asp Glu Gly Lys Phe Tyr Cys Lys Pro His Phe Ile His 
            820                 825                 830         


Cys Lys Thr Asn Ser Lys Gln Arg Lys Arg Arg Ala Glu Leu Lys Gln 
        835                 840                 845             


Gln Arg Glu Glu Glu Ala Thr Trp Gln Glu Gln Glu Ala Pro Arg Arg 
    850                 855                 860                 


Asp Thr Pro Thr Glu Ser Ser Cys Ala Val Ala Ala Ile Gly Thr Leu 
865                 870                 875                 880 


Glu Gly Ser Pro Pro Gly Ile Ser Thr Ser Phe Phe Arg Lys Val Leu 
                885                 890                 895     


Gly Trp Pro Leu Arg Leu Pro Arg Asp Leu Cys Asn Trp Met Gln Gly 
            900                 905                 910         


Leu Leu Gln Ala Ala Gly Leu His Ile Arg Asp Asn Ala Tyr Asn Tyr 
        915                 920                 925             


Cys Tyr Met Tyr Glu Leu Leu Ser Leu Gly Leu Pro Leu Leu Trp Ala 
    930                 935                 940                 


Phe Ser Glu Val Leu Ala Ala Met Tyr Arg Glu Ser Glu Gly Ser Leu 
945                 950                 955                 960 


Glu Ser Ile Cys Asn Trp Val Leu Arg Cys Phe Pro Val Lys Leu Arg 
                965                 970                 975     


<210>  310
<211>  633
<212>  PRT
<213>  Homo sapiens

<400>  310

Met Ala Ala Ala Ala Ala Ala Ala Thr Thr Ala Ala Cys Ser Ser Gly 
1               5                   10                  15      


Ser Ala Gly Thr Asp Ala Ala Gly Ala Ser Gly Leu Gln Gln Pro Pro 
            20                  25                  30          


Pro Gln Pro Gln Pro Gln Pro Ala Ala Ala Ala Pro Ala Gln Pro Pro 
        35                  40                  45              


Pro Glu Pro Pro Arg Lys Pro Arg Met Asp Pro Arg Arg Arg Gln Ala 
    50                  55                  60                  


Ala Leu Ser Phe Leu Thr Asn Ile Ser Leu Asp Gly Arg Leu Pro Pro 
65                  70                  75                  80  


Gln Asp Ala Glu Trp Gly Gly Gly Glu Glu Gly Gly Ala Ala Lys Pro 
                85                  90                  95      


Gly Ala Gly Gly Ala Cys Gly Ala Arg Thr Arg Phe Ser Leu Leu Ala 
            100                 105                 110         


Ala Ala Glu Arg Gly Gly Cys Ile Ala Leu Ala Ala Pro Gly Thr Pro 
        115                 120                 125             


Ala Ala Gly Leu Ala Ala Gly Ser Gly Pro Cys Leu Pro Gln Pro Ser 
    130                 135                 140                 


Ser Leu Pro Pro Leu Ile Pro Gly Gly His Ala Thr Val Ser Gly Pro 
145                 150                 155                 160 


Gly Val Ala Arg Gly Phe Ala Ser Pro Leu Gly Ala Gly Arg Ala Ser 
                165                 170                 175     


Gly Glu Gln Trp Gln Pro Pro Arg Pro Ala Pro Leu Ala Ala Cys Ala 
            180                 185                 190         


Gln Leu Gln Leu Leu Asp Gly Ser Gly Ala Ala Gly Gln Glu Glu Leu 
        195                 200                 205             


Glu Glu Asp Asp Ala Phe Ile Ser Val Gln Val Pro Ala Ala Ala Phe 
    210                 215                 220                 


Leu Gly Ser Gly Thr Pro Gly Ser Gly Ser Gly Ser Arg Gly Arg Leu 
225                 230                 235                 240 


Asn Ser Phe Thr Gln Gly Ile Leu Pro Ile Ala Phe Ser Arg Pro Thr 
                245                 250                 255     


Ser Gln Asn Tyr Cys Ser Leu Glu Gln Pro Gly Gln Gly Gly Ser Thr 
            260                 265                 270         


Ser Ala Phe Glu Gln Leu Gln Arg Ser Arg Arg Arg Leu Ile Ser Gln 
        275                 280                 285             


Arg Ser Ser Leu Glu Thr Leu Glu Asp Ile Glu Glu Asn Ala Pro Leu 
    290                 295                 300                 


Arg Arg Cys Arg Thr Leu Ser Gly Ser Pro Arg Pro Lys Asn Phe Lys 
305                 310                 315                 320 


Lys Ile His Phe Ile Lys Asn Met Arg Gln His Asp Thr Arg Asn Gly 
                325                 330                 335     


Arg Ile Val Leu Ile Ser Gly Arg Arg Ser Phe Cys Ser Ile Phe Ser 
            340                 345                 350         


Val Leu Pro Tyr Arg Asp Ser Thr Gln Val Gly Asp Leu Lys Leu Asp 
        355                 360                 365             


Gly Gly Arg Gln Ser Thr Gly Ala Val Ser Leu Lys Glu Ile Ile Gly 
    370                 375                 380                 


Leu Glu Gly Val Glu Leu Gly Ala Asp Gly Lys Thr Val Ser Tyr Thr 
385                 390                 395                 400 


Gln Phe Leu Leu Pro Thr Asn Ala Phe Gly Ala Arg Arg Asn Thr Ile 
                405                 410                 415     


Asp Ser Thr Ser Ser Phe Ser Gln Phe Arg Asn Leu Ser His Arg Ser 
            420                 425                 430         


Leu Ser Ile Gly Arg Ala Ser Gly Thr Gln Gly Ser Leu Asp Thr Gly 
        435                 440                 445             


Ser Asp Leu Gly Asp Phe Met Asp Tyr Asp Pro Asn Leu Leu Asp Asp 
    450                 455                 460                 


Pro Gln Trp Pro Cys Gly Lys His Lys Arg Val Leu Ile Phe Pro Ser 
465                 470                 475                 480 


Tyr Met Thr Thr Val Ile Asp Tyr Val Lys Pro Ser Asp Leu Lys Lys 
                485                 490                 495     


Asp Met Asn Glu Thr Phe Lys Glu Lys Phe Pro His Ile Lys Leu Thr 
            500                 505                 510         


Leu Ser Lys Ile Arg Ser Leu Lys Arg Glu Met Arg Lys Leu Ala Gln 
        515                 520                 525             


Glu Asp Cys Gly Leu Glu Glu Pro Thr Val Ala Met Ala Phe Val Tyr 
    530                 535                 540                 


Phe Glu Lys Leu Ala Leu Lys Gly Lys Leu Asn Lys Gln Asn Arg Lys 
545                 550                 555                 560 


Leu Cys Ala Gly Ala Cys Val Leu Leu Ala Ala Lys Ile Gly Ser Asp 
                565                 570                 575     


Leu Lys Lys His Glu Val Lys His Leu Ile Asp Lys Leu Glu Glu Lys 
            580                 585                 590         


Phe Arg Leu Asn Arg Arg Glu Leu Ile Ala Phe Glu Phe Pro Val Leu 
        595                 600                 605             


Val Ala Leu Glu Phe Ala Leu His Leu Pro Glu His Glu Val Met Pro 
    610                 615                 620                 


His Tyr Arg Arg Leu Val Gln Ser Ser 
625                 630             


<210>  311
<211>  38
<212>  PRT
<213>  Homo sapiens

<400>  311

Met Arg Gln His Asp Thr Arg Asn Gly Arg Ile Val Leu Ile Ser Gly 
1               5                   10                  15      


Arg Arg Ser Phe Cys Ser Ile Phe Ser Val Leu Pro Tyr Arg Asp Ser 
            20                  25                  30          


Thr Gln Val Gly Gln Gln 
        35              


<210>  312
<211>  301
<212>  PRT
<213>  Homo sapiens

<400>  312

Met Phe Ser His Leu Pro Phe Asp Cys Val Leu Leu Leu Leu Leu Leu 
1               5                   10                  15      


Leu Leu Thr Arg Ser Ser Glu Val Glu Tyr Arg Ala Glu Val Gly Gln 
            20                  25                  30          


Asn Ala Tyr Leu Pro Cys Phe Tyr Thr Pro Ala Ala Pro Gly Asn Leu 
        35                  40                  45              


Val Pro Val Cys Trp Gly Lys Gly Ala Cys Pro Val Phe Glu Cys Gly 
    50                  55                  60                  


Asn Val Val Leu Arg Thr Asp Glu Arg Asp Val Asn Tyr Trp Thr Ser 
65                  70                  75                  80  


Arg Tyr Trp Leu Asn Gly Asp Phe Arg Lys Gly Asp Val Ser Leu Thr 
                85                  90                  95      


Ile Glu Asn Val Thr Leu Ala Asp Ser Gly Ile Tyr Cys Cys Arg Ile 
            100                 105                 110         


Gln Ile Pro Gly Ile Met Asn Asp Glu Lys Phe Asn Leu Lys Leu Val 
        115                 120                 125             


Ile Lys Pro Ala Lys Val Thr Pro Ala Pro Thr Arg Gln Arg Asp Phe 
    130                 135                 140                 


Thr Ala Ala Phe Pro Arg Met Leu Thr Thr Arg Gly His Gly Pro Ala 
145                 150                 155                 160 


Glu Thr Gln Thr Leu Gly Ser Leu Pro Asp Ile Asn Leu Thr Gln Ile 
                165                 170                 175     


Ser Thr Leu Ala Asn Glu Leu Arg Asp Ser Arg Leu Ala Asn Asp Leu 
            180                 185                 190         


Arg Asp Ser Gly Ala Thr Ile Arg Ile Gly Ile Tyr Ile Gly Ala Gly 
        195                 200                 205             


Ile Cys Ala Gly Leu Ala Leu Ala Leu Ile Phe Gly Ala Leu Ile Phe 
    210                 215                 220                 


Lys Trp Tyr Ser His Ser Lys Glu Lys Ile Gln Asn Leu Ser Leu Ile 
225                 230                 235                 240 


Ser Leu Ala Asn Leu Pro Pro Ser Gly Leu Ala Asn Ala Val Ala Glu 
                245                 250                 255     


Gly Ile Arg Ser Glu Glu Asn Ile Tyr Thr Ile Glu Glu Asn Val Tyr 
            260                 265                 270         


Glu Val Glu Glu Pro Asn Glu Tyr Tyr Cys Tyr Val Ser Ser Arg Gln 
        275                 280                 285             


Gln Pro Ser Gln Pro Leu Gly Cys Arg Phe Ala Met Pro 
    290                 295                 300     


<210>  313
<211>  273
<212>  PRT
<213>  Homo sapiens

<400>  313

Met Phe Ser His Leu Pro Phe Asp Cys Val Leu Leu Leu Leu Leu Leu 
1               5                   10                  15      


Leu Leu Thr Arg Ser Ser Glu Val Glu Tyr Arg Ala Glu Val Gly Gln 
            20                  25                  30          


Asn Ala Tyr Leu Pro Cys Phe Tyr Thr Pro Ala Ala Pro Gly Asn Leu 
        35                  40                  45              


Val Pro Val Cys Trp Gly Lys Gly Ala Cys Pro Val Phe Glu Cys Gly 
    50                  55                  60                  


Asn Val Val Leu Arg Thr Asp Glu Arg Asp Val Asn Tyr Trp Thr Ser 
65                  70                  75                  80  


Arg Tyr Trp Leu Asn Gly Asp Phe Arg Lys Gly Asp Val Ser Leu Thr 
                85                  90                  95      


Ile Glu Asn Val Thr Leu Ala Asp Ser Gly Ile Tyr Cys Cys Arg Ile 
            100                 105                 110         


Gln Ile Pro Gly Ile Met Asn Asp Glu Lys Phe Asn Leu Lys Leu Val 
        115                 120                 125             


Ile Lys Pro Ala Glu Thr Gln Thr Leu Gly Ser Leu Pro Asp Ile Asn 
    130                 135                 140                 


Leu Thr Gln Ile Ser Thr Leu Ala Asn Glu Leu Arg Asp Ser Arg Leu 
145                 150                 155                 160 


Ala Asn Asp Leu Arg Asp Ser Gly Ala Thr Ile Arg Ile Gly Ile Tyr 
                165                 170                 175     


Ile Gly Ala Gly Ile Cys Ala Gly Leu Ala Leu Ala Leu Ile Phe Gly 
            180                 185                 190         


Ala Leu Ile Phe Lys Trp Tyr Ser His Ser Lys Glu Lys Ile Gln Asn 
        195                 200                 205             


Leu Ser Leu Ile Ser Leu Ala Asn Leu Pro Pro Ser Gly Leu Ala Asn 
    210                 215                 220                 


Ala Val Ala Glu Gly Ile Arg Ser Glu Glu Asn Ile Tyr Thr Ile Glu 
225                 230                 235                 240 


Glu Asn Val Tyr Glu Val Glu Glu Pro Asn Glu Tyr Tyr Cys Tyr Val 
                245                 250                 255     


Ser Ser Arg Gln Gln Pro Ser Gln Pro Leu Gly Cys Arg Phe Ala Met 
            260                 265                 270         


Pro 
    


<210>  314
<211>  116
<212>  PRT
<213>  Homo sapiens

<400>  314

Met Gln Leu Ser Phe Trp Ser His Cys Arg Cys Phe Cys Met Phe Ser 
1               5                   10                  15      


Ile Pro Leu Leu Met Cys Arg Val Arg Asp Gln Ile Cys Asp Cys Pro 
            20                  25                  30          


Glu Cys Thr Leu Gln Glu Asn Pro Phe Phe Ser Gln Pro Gly Ala Pro 
        35                  40                  45              


Ile Leu Gln Cys Met Gly Cys Cys Phe Ser Arg Ala Tyr Pro Thr Pro 
    50                  55                  60                  


Leu Arg Ser Lys Lys Thr Met Leu Val Gln Lys Asn Val Thr Ser Glu 
65                  70                  75                  80  


Ser Thr Cys Cys Val Ala Lys Ser Tyr Asn Arg Val Thr Val Met Gly 
                85                  90                  95      


Gly Phe Lys Val Glu Asn His Thr Ala Cys His Cys Ser Thr Cys Tyr 
            100                 105                 110         


Tyr His Lys Ser 
        115     


<210>  315
<211>  147
<212>  PRT
<213>  Homo sapiens

<400>  315

Met Asp Tyr Tyr Arg Lys Tyr Ala Ala Ile Phe Leu Val Thr Leu Ser 
1               5                   10                  15      


Val Phe Leu His Val Leu His Ser Ala Pro Asp Val Gln Glu Thr Gly 
            20                  25                  30          


Phe His His Val Ala Gln Ala Ala Leu Lys Leu Leu Ser Ser Ser Asn 
        35                  40                  45              


Pro Pro Thr Lys Ala Ser Gln Ser Ala Arg Ile Thr Asp Cys Pro Glu 
    50                  55                  60                  


Cys Thr Leu Gln Glu Asn Pro Phe Phe Ser Gln Pro Gly Ala Pro Ile 
65                  70                  75                  80  


Leu Gln Cys Met Gly Cys Cys Phe Ser Arg Ala Tyr Pro Thr Pro Leu 
                85                  90                  95      


Arg Ser Lys Lys Thr Met Leu Val Gln Lys Asn Val Thr Ser Glu Ser 
            100                 105                 110         


Thr Cys Cys Val Ala Lys Ser Tyr Asn Arg Val Thr Val Met Gly Gly 
        115                 120                 125             


Phe Lys Val Glu Asn His Thr Ala Cys His Cys Ser Thr Cys Tyr Tyr 
    130                 135                 140                 


His Lys Ser 
145         


<210>  316
<211>  62
<212>  PRT
<213>  Homo sapiens

<400>  316

Met Asp Tyr Tyr Arg Lys Tyr Ala Ala Ile Phe Leu Val Thr Leu Ser 
1               5                   10                  15      


Val Phe Leu His Val Leu His Ser Ala Pro Asp Val Gln Asp Cys Pro 
            20                  25                  30          


Glu Cys Thr Leu Gln Glu Asn Pro Phe Phe Ser Gln Pro Gly Ala Pro 
        35                  40                  45              


Ile Leu Gln Cys Met Gly Cys Cys Phe Ser Arg Ala Tyr Pro 
    50                  55                  60          


<210>  317
<211>  116
<212>  PRT
<213>  Homo sapiens

<400>  317

Met Asp Tyr Tyr Arg Lys Tyr Ala Ala Ile Phe Leu Val Thr Leu Ser 
1               5                   10                  15      


Val Phe Leu His Val Leu His Ser Ala Pro Asp Val Gln Asp Cys Pro 
            20                  25                  30          


Glu Cys Thr Leu Gln Glu Asn Pro Phe Phe Ser Gln Pro Gly Ala Pro 
        35                  40                  45              


Ile Leu Gln Cys Met Gly Cys Cys Phe Ser Arg Ala Tyr Pro Thr Pro 
    50                  55                  60                  


Leu Arg Ser Lys Lys Thr Met Leu Val Gln Lys Asn Val Thr Ser Glu 
65                  70                  75                  80  


Ser Thr Cys Cys Val Ala Lys Ser Tyr Asn Arg Val Thr Val Met Gly 
                85                  90                  95      


Gly Phe Lys Val Glu Asn His Thr Ala Cys His Cys Ser Thr Cys Tyr 
            100                 105                 110         


Tyr His Lys Ser 
        115     


<210>  318
<211>  101
<212>  PRT
<213>  Homo sapiens

<400>  318

Met Asp Tyr Tyr Arg Lys Tyr Ala Ala Ile Phe Leu Val Thr Leu Ser 
1               5                   10                  15      


Val Phe Leu His Val Leu His Ser Ala Pro Asp Val Gln Asp Cys Pro 
            20                  25                  30          


Glu Cys Thr Leu Gln Glu Asn Pro Phe Phe Ser Gln Pro Gly Ala Pro 
        35                  40                  45              


Ile Leu Gln Cys Met Gly Cys Cys Phe Ser Arg Ala Tyr Pro Thr Pro 
    50                  55                  60                  


Leu Arg Ser Lys Lys Thr Met Leu Val Gln Lys Asn Val Thr Ser Glu 
65                  70                  75                  80  


Ser Thr Cys Cys Val Ala Lys Ser Tyr Asn Arg Val Arg Thr Ser Arg 
                85                  90                  95      


Ser Pro Glu Ala Phe 
            100     


<210>  319
<211>  316
<212>  PRT
<213>  Homo sapiens

<400>  319

Met Thr Gln Gly Lys Leu Ser Val Ala Asn Lys Ala Pro Gly Thr Glu 
1               5                   10                  15      


Gly Gln Gln Gln Val His Gly Glu Lys Lys Glu Ala Pro Ala Val Pro 
            20                  25                  30          


Ser Ala Pro Pro Ser Tyr Glu Glu Ala Thr Ser Gly Glu Gly Met Lys 
        35                  40                  45              


Ala Gly Ala Phe Pro Pro Ala Pro Thr Ala Val Pro Leu His Pro Ser 
    50                  55                  60                  


Trp Ala Tyr Val Asp Pro Ser Ser Ser Ser Ser Tyr Asp Asn Gly Phe 
65                  70                  75                  80  


Pro Thr Gly Asp His Glu Leu Phe Thr Thr Phe Ser Trp Asp Asp Gln 
                85                  90                  95      


Lys Val Arg Arg Val Phe Val Arg Lys Val Tyr Thr Ile Leu Leu Ile 
            100                 105                 110         


Gln Leu Leu Val Thr Leu Ala Val Val Ala Leu Phe Thr Phe Cys Asp 
        115                 120                 125             


Pro Val Lys Asp Tyr Val Gln Ala Asn Pro Gly Trp Tyr Trp Ala Ser 
    130                 135                 140                 


Tyr Ala Val Phe Phe Ala Thr Tyr Leu Thr Leu Ala Cys Cys Ser Gly 
145                 150                 155                 160 


Pro Arg Arg His Phe Pro Trp Asn Leu Ile Leu Leu Thr Val Phe Thr 
                165                 170                 175     


Leu Ser Met Ala Tyr Leu Thr Gly Met Leu Ser Ser Tyr Tyr Asn Thr 
            180                 185                 190         


Thr Ser Val Leu Leu Cys Leu Gly Ile Thr Ala Leu Val Cys Leu Ser 
        195                 200                 205             


Val Thr Val Phe Ser Phe Gln Thr Lys Phe Asp Phe Thr Ser Cys Gln 
    210                 215                 220                 


Gly Val Leu Phe Val Leu Leu Met Thr Leu Phe Phe Ser Gly Leu Ile 
225                 230                 235                 240 


Leu Ala Ile Leu Leu Pro Phe Gln Tyr Val Pro Trp Leu His Ala Val 
                245                 250                 255     


Tyr Ala Ala Leu Gly Ala Gly Val Phe Thr Leu Phe Leu Ala Leu Asp 
            260                 265                 270         


Thr Gln Leu Leu Met Gly Asn Arg Arg His Ser Leu Ser Pro Glu Glu 
        275                 280                 285             


Tyr Ile Phe Gly Ala Leu Asn Ile Tyr Leu Asp Ile Ile Tyr Ile Phe 
    290                 295                 300                 


Thr Phe Phe Leu Gln Leu Phe Gly Thr Asn Arg Glu 
305                 310                 315     


<210>  320
<211>  111
<212>  PRT
<213>  Homo sapiens

<400>  320

Met Lys Ala Gly Ala Phe Pro Pro Ala Pro Thr Ala Val Pro Leu His 
1               5                   10                  15      


Pro Ser Trp Ala Tyr Val Asp Pro Ser Ser Ser Ser Ser Tyr Asp Asn 
            20                  25                  30          


Gly Phe Pro Thr Gly Asp His Glu Leu Phe Thr Thr Phe Ser Trp Asp 
        35                  40                  45              


Asp Gln Lys Val Arg Arg Val Phe Val Arg Lys Val Tyr Thr Ile Leu 
    50                  55                  60                  


Leu Ile Gln Leu Leu Val Thr Leu Ala Val Val Ala Leu Phe Thr Phe 
65                  70                  75                  80  


Cys Asp Pro Val Lys Asp Tyr Val Gln Ala Asn Pro Gly Trp Tyr Trp 
                85                  90                  95      


Ala Ser Tyr Ala Val Phe Phe Ala Thr Tyr Leu Thr Leu Ala Cys 
            100                 105                 110     


<210>  321
<211>  208
<212>  PRT
<213>  Homo sapiens

<400>  321

Met Thr Gln Gly Lys Leu Ser Val Ala Asn Lys Ala Pro Gly Thr Glu 
1               5                   10                  15      


Gly Gln Gln Gln Val His Gly Glu Lys Lys Glu Ala Pro Ala Val Pro 
            20                  25                  30          


Ser Ala Pro Pro Ser Tyr Glu Glu Ala Thr Ser Gly Glu Gly Met Lys 
        35                  40                  45              


Ala Gly Ala Phe Pro Pro Ala Pro Thr Ala Val Pro Leu His Pro Ser 
    50                  55                  60                  


Trp Ala Tyr Val Asp Pro Ser Ser Ser Ser Ser Tyr Asp Asn Gly Phe 
65                  70                  75                  80  


Pro Thr Gly Asp His Glu Leu Phe Thr Thr Phe Ser Trp Asp Asp Gln 
                85                  90                  95      


Lys Val Arg Arg Val Phe Val Arg Lys Asn Pro Ser His Pro Gln Val 
            100                 105                 110         


Tyr Thr Ile Leu Leu Ile Gln Leu Leu Val Thr Leu Ala Val Val Ala 
        115                 120                 125             


Leu Phe Thr Phe Cys Asp Pro Val Lys Asp Tyr Val Gln Ala Asn Pro 
    130                 135                 140                 


Gly Trp Tyr Trp Ala Ser Tyr Ala Val Phe Phe Ala Thr Tyr Leu Thr 
145                 150                 155                 160 


Leu Ala Cys Cys Ser Gly Pro Arg Arg His Phe Pro Trp Asn Leu Ile 
                165                 170                 175     


Leu Leu Thr Val Phe Thr Leu Ser Met Ala Tyr Leu Thr Gly Met Leu 
            180                 185                 190         


Ser Ser Ser Thr Ser Pro Pro Ala Arg Ala Cys Ser Ser Cys Phe Ser 
        195                 200                 205             


<210>  322
<211>  248
<212>  PRT
<213>  Homo sapiens

<400>  322

Met Thr Gln Gly Lys Leu Ser Val Ala Asn Lys Ala Pro Gly Thr Glu 
1               5                   10                  15      


Gly Gln Gln Gln Val His Gly Glu Lys Lys Glu Ala Pro Ala Val Pro 
            20                  25                  30          


Ser Ala Pro Pro Ser Tyr Glu Glu Ala Thr Ser Gly Glu Gly Met Lys 
        35                  40                  45              


Ala Gly Ala Phe Pro Pro Ala Pro Thr Ala Val Pro Leu His Pro Ser 
    50                  55                  60                  


Trp Ala Tyr Val Asp Pro Ser Ser Ser Ser Ser Tyr Asp Asn Gly Phe 
65                  70                  75                  80  


Pro Thr Gly Asp His Glu Leu Phe Thr Thr Phe Ser Trp Asp Asp Gln 
                85                  90                  95      


Lys Val Arg Arg Val Phe Val Arg Lys Val Tyr Thr Ile Leu Leu Ile 
            100                 105                 110         


Gln Leu Leu Val Thr Leu Ala Val Val Ala Leu Phe Thr Phe Cys Asp 
        115                 120                 125             


Pro Val Lys Asp Tyr Val Gln Ala Asn Pro Gly Trp Tyr Trp Ala Ser 
    130                 135                 140                 


Tyr Ala Val Phe Phe Ala Thr Tyr Leu Thr Leu Ala Cys Cys Ser Gly 
145                 150                 155                 160 


Pro Arg Arg His Phe Pro Trp Asn Leu Ile Leu Leu Thr Val Phe Thr 
                165                 170                 175     


Leu Ser Met Ala Tyr Leu Thr Gly Met Leu Ser Ser Tyr Tyr Asn Thr 
            180                 185                 190         


Thr Ser Val Leu Leu Cys Leu Gly Ile Thr Ala Leu Val Cys Leu Ser 
        195                 200                 205             


Val Thr Val Phe Ser Phe Gln Thr Lys Phe Asp Phe Thr Ser Cys Gln 
    210                 215                 220                 


Gly Val Leu Phe Val Leu Leu Met Thr Leu Phe Phe Ser Gly Leu Ile 
225                 230                 235                 240 


Leu Ala Ile Leu Leu Pro Phe Gln 
                245             


<210>  323
<211>  270
<212>  PRT
<213>  Homo sapiens

<400>  323

Met Lys Ala Gly Ala Phe Pro Pro Ala Pro Thr Ala Val Pro Leu His 
1               5                   10                  15      


Pro Ser Trp Ala Tyr Val Asp Pro Ser Ser Ser Ser Ser Tyr Asp Asn 
            20                  25                  30          


Gly Phe Pro Thr Gly Asp His Glu Leu Phe Thr Thr Phe Ser Trp Asp 
        35                  40                  45              


Asp Gln Lys Val Arg Arg Val Phe Val Arg Lys Val Tyr Thr Ile Leu 
    50                  55                  60                  


Leu Ile Gln Leu Leu Val Thr Leu Ala Val Val Ala Leu Phe Thr Phe 
65                  70                  75                  80  


Cys Asp Pro Val Lys Asp Tyr Val Gln Ala Asn Pro Gly Trp Tyr Trp 
                85                  90                  95      


Ala Ser Tyr Ala Val Phe Phe Ala Thr Tyr Leu Thr Leu Ala Cys Cys 
            100                 105                 110         


Ser Gly Pro Arg Arg His Phe Pro Trp Asn Leu Ile Leu Leu Thr Val 
        115                 120                 125             


Phe Thr Leu Ser Met Ala Tyr Leu Thr Gly Met Leu Ser Ser Tyr Tyr 
    130                 135                 140                 


Asn Thr Thr Ser Val Leu Leu Cys Leu Gly Ile Thr Ala Leu Val Cys 
145                 150                 155                 160 


Leu Ser Val Thr Val Phe Ser Phe Gln Thr Lys Phe Asp Phe Thr Ser 
                165                 170                 175     


Cys Gln Gly Val Leu Phe Val Leu Leu Met Thr Leu Phe Phe Ser Gly 
            180                 185                 190         


Leu Ile Leu Ala Ile Leu Leu Pro Phe Gln Tyr Val Pro Trp Leu His 
        195                 200                 205             


Ala Val Tyr Ala Ala Leu Gly Ala Gly Val Phe Thr Leu Phe Leu Ala 
    210                 215                 220                 


Leu Asp Thr Gln Leu Leu Met Gly Asn Arg Arg His Ser Leu Ser Pro 
225                 230                 235                 240 


Glu Glu Tyr Ile Phe Gly Ala Leu Asn Ile Tyr Leu Asp Ile Ile Tyr 
                245                 250                 255     


Ile Phe Thr Phe Phe Leu Gln Leu Phe Gly Thr Asn Arg Glu 
            260                 265                 270 


<210>  324
<211>  266
<212>  PRT
<213>  Homo sapiens

<400>  324

Met Val Tyr Thr Ser His Tyr Lys Ser Pro Gly Arg Arg Pro Leu Lys 
1               5                   10                  15      


Thr His Pro Thr Val Thr Tyr Trp Arg Val Asn Glu Gly Ser Ser Ser 
            20                  25                  30          


Ser Tyr Asp Asn Gly Phe Pro Thr Gly Asp His Glu Leu Phe Thr Thr 
        35                  40                  45              


Phe Ser Trp Asp Asp Gln Lys Val Arg Arg Val Phe Val Arg Lys Val 
    50                  55                  60                  


Tyr Thr Ile Leu Leu Ile Gln Leu Leu Val Thr Leu Ala Val Val Ala 
65                  70                  75                  80  


Leu Phe Thr Phe Cys Asp Pro Val Lys Asp Tyr Val Gln Ala Asn Pro 
                85                  90                  95      


Gly Trp Tyr Trp Ala Ser Tyr Ala Val Phe Phe Ala Thr Tyr Leu Thr 
            100                 105                 110         


Leu Ala Cys Cys Ser Gly Pro Arg Arg His Phe Pro Trp Asn Leu Ile 
        115                 120                 125             


Leu Leu Thr Val Phe Thr Leu Ser Met Ala Tyr Leu Thr Gly Met Leu 
    130                 135                 140                 


Ser Ser Tyr Tyr Asn Thr Thr Ser Val Leu Leu Cys Leu Gly Ile Thr 
145                 150                 155                 160 


Ala Leu Val Cys Leu Ser Val Thr Val Phe Ser Phe Gln Thr Lys Phe 
                165                 170                 175     


Asp Phe Thr Ser Cys Gln Gly Val Leu Phe Val Leu Leu Met Thr Leu 
            180                 185                 190         


Phe Phe Ser Gly Leu Ile Leu Ala Ile Leu Leu Pro Phe Gln Tyr Val 
        195                 200                 205             


Pro Trp Leu His Ala Val Tyr Ala Ala Leu Gly Ala Gly Val Phe Thr 
    210                 215                 220                 


Leu Phe Leu Ala Leu Asp Thr Gln Leu Leu Met Gly Asn Arg Arg His 
225                 230                 235                 240 


Ser Leu Ser Pro Glu Glu Tyr Ile Phe Gly Ala Leu Asn Ile Tyr Leu 
                245                 250                 255     


Asp Ile Ile Tyr Ile Phe Thr Phe Phe Leu 
            260                 265     


<210>  325
<211>  145
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  325

Xaa Tyr Val Gln Ala Asn Pro Gly Trp Tyr Trp Ala Ser Tyr Ala Val 
1               5                   10                  15      


Phe Phe Ala Thr Tyr Leu Thr Leu Ala Cys Cys Ser Gly Pro Arg Arg 
            20                  25                  30          


His Phe Pro Trp Asn Leu Ile Leu Leu Thr Val Phe Thr Leu Ser Met 
        35                  40                  45              


Ala Tyr Leu Thr Gly Met Leu Ser Ser Tyr Tyr Asn Thr Thr Ser Val 
    50                  55                  60                  


Leu Leu Cys Leu Gly Ile Thr Ala Leu Val Cys Leu Ser Val Thr Val 
65                  70                  75                  80  


Phe Ser Phe Gln Thr Lys Phe Asp Phe Thr Ser Cys Gln Gly Val Leu 
                85                  90                  95      


Phe Val Leu Leu Met Thr Leu Phe Phe Ser Gly Leu Ile Leu Ala Ile 
            100                 105                 110         


Leu Leu Pro Phe Gln Tyr Phe Leu Ala Leu Asp Thr Gln Leu Leu Met 
        115                 120                 125             


Gly Asn Arg Arg His Ser Leu Ser Pro Glu Glu Tyr Ile Phe Gly Ala 
    130                 135                 140                 


Leu 
145 


<210>  326
<211>  695
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  326

Xaa Glu Gly Gly Gln Gly Pro Arg Gly Leu Gly Thr Val Pro Trp Leu 
1               5                   10                  15      


Arg Asp Leu Pro Gly Ser Glu Asn His Met Pro Trp Glu Glu Pro Ala 
            20                  25                  30          


Gly Glu Lys Pro Ser Cys Ser His Ser Gln Lys Ala Phe His Met Glu 
        35                  40                  45              


Pro Ala Gln Lys Pro Cys Phe Thr Thr Asp Met Val Thr Trp Ala Leu 
    50                  55                  60                  


Leu Cys Ile Ser Ala Glu Thr Val Arg Gly Glu Ala Pro Ser Gln Pro 
65                  70                  75                  80  


Arg Gly Ile Pro His Arg Ser Pro Val Ser Val Asp Asp Leu Trp Leu 
                85                  90                  95      


Glu Lys Thr Gln Arg Lys Lys Leu Gln Lys Gln Ala His Val Glu Arg 
            100                 105                 110         


Arg Leu His Ile Gly Ala Val His Lys Asp Gly Val Lys Cys Trp Arg 
        115                 120                 125             


Lys Thr Ile Ile Thr Ser Pro Glu Ser Leu Asn Leu Pro Arg Arg Ser 
    130                 135                 140                 


His Pro Leu Ser Gln Ser Ala Pro Thr Gly Leu Asn His Met Gly Trp 
145                 150                 155                 160 


Pro Glu His Thr Pro Gly Thr Ala Met Pro Asp Gly Ala Leu Asp Thr 
                165                 170                 175     


Ala Val Cys Ala Asp Glu Val Gly Ser Glu Glu Asp Leu Tyr Asp Asp 
            180                 185                 190         


Leu His Ser Ser Ser His His Tyr Ser His Pro Gly Gly Gly Gly Glu 
        195                 200                 205             


Gln Leu Ala Ile Asn Glu Leu Ile Ser Asp Gly Ser Val Val Cys Ala 
    210                 215                 220                 


Glu Ala Leu Trp Asp His Val Thr Met Asp Asp Gln Glu Leu Gly Phe 
225                 230                 235                 240 


Lys Ala Gly Asp Val Ile Glu Val Met Asp Ala Thr Asn Arg Glu Trp 
                245                 250                 255     


Trp Trp Gly Arg Val Ala Asp Gly Glu Gly Trp Phe Pro Ala Ser Phe 
            260                 265                 270         


Val Arg Leu Arg Val Asn Gln Asp Glu Pro Ala Asp Asp Asp Ala Pro 
        275                 280                 285             


Leu Ala Gly Asn Ser Gly Ala Glu Asp Gly Gly Ala Glu Ala Gln Ser 
    290                 295                 300                 


Ser Lys Asp Gln Met Arg Thr Asn Val Ile Asn Glu Ile Leu Ser Thr 
305                 310                 315                 320 


Glu Arg Asp Tyr Ile Lys His Leu Arg Asp Ile Cys Glu Gly Tyr Val 
                325                 330                 335     


Arg Gln Cys Arg Lys Arg Ala Asp Met Phe Ser Glu Glu Gln Leu Arg 
            340                 345                 350         


Thr Ile Phe Gly Asn Ile Glu Asp Ile Tyr Arg Cys Gln Lys Ala Phe 
        355                 360                 365             


Val Lys Ala Leu Glu Gln Arg Phe Asn Arg Glu Arg Pro His Leu Ser 
    370                 375                 380                 


Glu Leu Gly Ala Cys Phe Leu Glu His Gln Ala Asp Phe Gln Ile Tyr 
385                 390                 395                 400 


Ser Glu Tyr Cys Asn Asn His Pro Asn Ala Cys Val Glu Leu Ser Arg 
                405                 410                 415     


Leu Thr Lys Leu Ser Lys Tyr Val Tyr Phe Phe Glu Ala Cys Arg Leu 
            420                 425                 430         


Leu Gln Lys Met Ile Asp Ile Ser Leu Asp Gly Phe Leu Leu Thr Pro 
        435                 440                 445             


Val Gln Lys Ile Cys Lys Tyr Pro Leu Gln Leu Ala Glu Leu Leu Lys 
    450                 455                 460                 


Tyr Thr His Pro Gln His Arg Asp Phe Lys Asp Val Glu Ala Ala Leu 
465                 470                 475                 480 


His Ala Met Lys Asn Val Ala Gln Leu Ile Asn Glu Arg Lys Arg Arg 
                485                 490                 495     


Leu Glu Asn Ile Asp Lys Ile Ala Gln Trp Gln Ser Ser Ile Glu Asp 
            500                 505                 510         


Trp Glu Gly Glu Asp Leu Leu Val Arg Ser Ser Glu Leu Ile Tyr Ser 
        515                 520                 525             


Gly Glu Leu Thr Arg Val Thr Gln Pro Gln Ala Lys Ser Gln Gln Arg 
    530                 535                 540                 


Met Phe Phe Leu Phe Asp His Gln Leu Ile Tyr Cys Lys Lys Asp Leu 
545                 550                 555                 560 


Leu Arg Arg Asp Val Leu Tyr Tyr Lys Gly Arg Leu Asp Met Asp Gly 
                565                 570                 575     


Leu Glu Val Val Asp Leu Glu Asp Gly Lys Asp Arg Asp Leu His Val 
            580                 585                 590         


Ser Ile Lys Asn Ala Phe Arg Leu His Arg Gly Ala Thr Gly Asp Ser 
        595                 600                 605             


His Leu Leu Cys Thr Arg Lys Pro Glu Gln Lys Gln Arg Trp Leu Lys 
    610                 615                 620                 


Ala Phe Ala Arg Glu Arg Glu Gln Val Gln Leu Asp Gln Glu Thr Gly 
625                 630                 635                 640 


Phe Ser Ile Thr Glu Leu Gln Arg Lys Gln Ala Met Leu Asn Ala Ser 
                645                 650                 655     


Lys Gln Gln Val Thr Gly Lys Pro Lys Gly Arg Arg Thr Ala Ala Pro 
            660                 665                 670         


Pro Pro Arg Leu Pro Gly Pro Tyr Pro Ala Asp Ile Ile Pro Phe Ser 
        675                 680                 685             


Glu Pro Gln Ser Gln Ala Ser 
    690                 695 


<210>  327
<211>  573
<212>  PRT
<213>  Homo sapiens

<400>  327

Met Thr Asn Ser Lys Gly Arg Ser Ile Thr Asp Lys Thr Ser Gly Gly 
1               5                   10                  15      


Pro Ser Ser Gly Gly Gly Phe Val Asp Trp Thr Leu Arg Leu Asn Thr 
            20                  25                  30          


Ile Gln Ser Asp Lys Phe Leu Asn Leu Leu Leu Ser Met Val Pro Val 
        35                  40                  45              


Ile Tyr Gln Lys Asn Gln Glu Asp Arg His Lys Lys Ala Asn Gly Ile 
    50                  55                  60                  


Trp Gln Asp Gly Leu Ser Thr Ala Val Gln Thr Phe Ser Asn Arg Ser 
65                  70                  75                  80  


Glu Gln His Met Glu Tyr His Ser Phe Ser Glu Gln Ser Phe His Ala 
                85                  90                  95      


Asn Asn Gly His Ala Ser Ser Ser Cys Ser Gln Lys Tyr Asp Asp Tyr 
            100                 105                 110         


Ala Asn Tyr Asn Tyr Cys Asp Gly Arg Glu Thr Ser Glu Thr Thr Ala 
        115                 120                 125             


Met Leu Gln Asp Glu Asp Ile Ser Ser Asp Gly Asp Glu Asp Ala Ile 
    130                 135                 140                 


Val Glu Val Thr Pro Lys Leu Pro Lys Glu Ser Ser Gly Ile Met Ala 
145                 150                 155                 160 


Leu Gln Ile Leu Val Pro Phe Leu Leu Ala Gly Phe Gly Thr Val Ser 
                165                 170                 175     


Ala Gly Met Val Leu Asp Ile Val Gln His Trp Glu Val Phe Arg Lys 
            180                 185                 190         


Val Thr Glu Val Phe Ile Leu Val Pro Ala Leu Leu Gly Leu Lys Gly 
        195                 200                 205             


Asn Leu Glu Met Thr Leu Ala Ser Arg Leu Ser Thr Ala Val Asn Ile 
    210                 215                 220                 


Gly Lys Met Asp Ser Pro Ile Glu Lys Trp Asn Leu Ile Ile Gly Asn 
225                 230                 235                 240 


Leu Ala Leu Lys Gln Val Gln Ala Thr Val Val Gly Phe Leu Ala Ala 
                245                 250                 255     


Val Ala Ala Ile Ile Leu Gly Trp Ile Pro Glu Gly Lys Tyr Tyr Leu 
            260                 265                 270         


Asp His Ser Ile Leu Leu Cys Ser Ser Ser Val Ala Thr Ala Phe Ile 
        275                 280                 285             


Ala Ser Leu Leu Gln Gly Ile Ile Met Val Gly Val Ile Val Gly Ser 
    290                 295                 300                 


Lys Lys Thr Gly Ile Asn Pro Asp Asn Val Ala Thr Pro Ile Ala Ala 
305                 310                 315                 320 


Ser Phe Gly Asp Leu Ile Thr Leu Ala Ile Leu Ala Trp Ile Ser Gln 
                325                 330                 335     


Gly Leu Tyr Ser Cys Leu Glu Thr Tyr Tyr Tyr Ile Ser Pro Leu Val 
            340                 345                 350         


Gly Val Phe Phe Leu Ala Leu Thr Pro Ile Trp Ile Ile Ile Ala Ala 
        355                 360                 365             


Lys His Pro Ala Thr Arg Thr Val Leu His Ser Gly Trp Glu Pro Val 
    370                 375                 380                 


Ile Thr Ala Met Val Ile Ser Ser Ile Gly Gly Leu Ile Leu Asp Thr 
385                 390                 395                 400 


Thr Val Ser Asp Pro Asn Leu Val Gly Ile Val Val Tyr Thr Pro Val 
                405                 410                 415     


Ile Asn Gly Ile Gly Gly Asn Leu Val Ala Ile Gln Ala Ser Arg Ile 
            420                 425                 430         


Ser Thr Tyr Leu His Leu His Ser Ile Pro Gly Glu Leu Pro Asp Glu 
        435                 440                 445             


Pro Lys Gly Cys Tyr Tyr Pro Phe Arg Thr Phe Phe Gly Pro Gly Val 
    450                 455                 460                 


Asn Asn Lys Ser Ala Gln Val Leu Leu Leu Leu Val Ile Pro Gly His 
465                 470                 475                 480 


Leu Ile Phe Leu Tyr Thr Ile His Leu Met Lys Ser Gly His Thr Ser 
                485                 490                 495     


Leu Thr Ile Ile Phe Ile Val Val Tyr Leu Phe Gly Ala Val Leu Gln 
            500                 505                 510         


Val Phe Thr Leu Leu Trp Ile Ala Asp Trp Met Val His His Phe Trp 
        515                 520                 525             


Arg Lys Gly Lys Asp Pro Asp Ser Phe Ser Ile Pro Tyr Leu Thr Ala 
    530                 535                 540                 


Leu Gly Asp Leu Leu Gly Thr Ala Leu Leu Ala Leu Ser Phe His Phe 
545                 550                 555                 560 


Leu Trp Leu Ile Gly Asp Arg Asp Gly Asp Val Gly Asp 
                565                 570             


<210>  328
<211>  149
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  328

Xaa Asp Asp Tyr Ala Asn Tyr Asn Tyr Cys Asp Gly Arg Glu Thr Ser 
1               5                   10                  15      


Glu Thr Thr Ala Met Leu Gln Asp Glu Asp Ile Ser Ser Asp Gly Asp 
            20                  25                  30          


Glu Asp Ala Ile Val Glu Val Thr Pro Lys Leu Pro Lys Glu Ser Ser 
        35                  40                  45              


Gly Ile Met Ala Leu Gln Ile Leu Val Pro Phe Leu Leu Ala Gly Phe 
    50                  55                  60                  


Gly Thr Val Ser Ala Gly Met Val Leu Asp Ile Val Gln Val Asn Ile 
65                  70                  75                  80  


Gly Lys Met Asp Ser Pro Ile Glu Lys Trp Asn Leu Ile Ile Gly Asn 
                85                  90                  95      


Leu Ala Leu Lys Gln Val Gln Ala Thr Val Val Gly Phe Leu Ala Ala 
            100                 105                 110         


Val Ala Ala Ile Ile Leu Gly Trp Ile Pro Glu Gly Lys Tyr Tyr Leu 
        115                 120                 125             


Asp His Ser Ile Leu Leu Cys Ser Ser Ser Val Ala Thr Ala Phe Ile 
    130                 135                 140                 


Ala Ser Leu Leu Gln 
145                 


<210>  329
<211>  68
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  329

Xaa Leu Lys Ala Leu Lys Gly Tyr Ile Lys His Glu Ala Arg Lys Gly 
1               5                   10                  15      


Asn Glu Asn Gln Asp Ser Ser Thr Ser Lys Arg Lys Thr Leu Cys Gly 
            20                  25                  30          


Phe Tyr Ser His Gln Pro Thr Thr Leu Ala Arg Pro Val Leu Trp Pro 
        35                  40                  45              


Cys Lys Ser Glu Tyr Leu Gly Ser Glu Gly Val Thr Gln Ala Leu Cys 
    50                  55                  60                  


Tyr Leu Cys Ser 
65              


<210>  330
<211>  76
<212>  PRT
<213>  Homo sapiens

<400>  330

Met Ile Ile Pro Ser Leu Glu Glu Leu Asp Ser Leu Lys Tyr Ser Asp 
1               5                   10                  15      


Leu Gln Asn Leu Ala Lys Ser Leu Gly Leu Arg Ala Asn Leu Arg Ala 
            20                  25                  30          


Thr Lys Leu Leu Lys Ala Leu Lys Gly Tyr Ile Lys His Glu Ala Arg 
        35                  40                  45              


Lys Gly Asn Glu Asn Gln Phe His Ser Cys Cys Pro Gly Trp Ser Ala 
    50                  55                  60                  


Met Thr Arg Ser Arg Leu Thr Ala Thr Ser Thr Ser 
65                  70                  75      


<210>  331
<211>  748
<212>  PRT
<213>  Homo sapiens

<400>  331

Met Val Leu Leu Arg Val Leu Ile Leu Leu Leu Ser Trp Ala Ala Gly 
1               5                   10                  15      


Met Gly Gly Gln Tyr Gly Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr 
            20                  25                  30          


Glu Gly Leu Ser Tyr Asn Val Asp Ser Leu His Gln Lys His Gln Arg 
        35                  40                  45              


Ala Lys Arg Ala Val Ser His Glu Asp Gln Phe Leu Arg Leu Asp Phe 
    50                  55                  60                  


His Ala His Gly Arg His Phe Asn Leu Arg Met Lys Arg Asp Thr Ser 
65                  70                  75                  80  


Leu Phe Ser Asp Glu Phe Lys Val Glu Thr Ser Asn Lys Val Leu Asp 
                85                  90                  95      


Tyr Asp Thr Ser His Ile Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly 
            100                 105                 110         


Ser Phe Ser His Gly Ser Val Ile Asp Gly Arg Phe Glu Gly Phe Ile 
        115                 120                 125             


Gln Thr Arg Gly Gly Thr Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile 
    130                 135                 140                 


Lys Asp Arg Thr Leu Pro Phe His Ser Val Ile Tyr His Glu Asp Asp 
145                 150                 155                 160 


Ile Asn Tyr Pro His Lys Tyr Gly Pro Gln Gly Gly Cys Ala Asp His 
                165                 170                 175     


Ser Val Phe Glu Arg Met Arg Lys Tyr Gln Met Thr Gly Val Glu Glu 
            180                 185                 190         


Val Thr Gln Ile Pro Gln Glu Glu His Ala Ala Asn Gly Pro Glu Leu 
        195                 200                 205             


Leu Arg Lys Lys Arg Thr Thr Ser Ala Glu Lys Asn Thr Cys Gln Leu 
    210                 215                 220                 


Tyr Ile Gln Thr Asp His Leu Phe Phe Lys Tyr Tyr Gly Thr Arg Glu 
225                 230                 235                 240 


Ala Val Ile Ala Gln Ile Ser Ser His Val Lys Ala Ile Asp Thr Ile 
                245                 250                 255     


Tyr Gln Thr Thr Asp Phe Ser Gly Ile Arg Asn Ile Ser Phe Met Val 
            260                 265                 270         


Lys Arg Ile Arg Ile Asn Thr Thr Ala Asp Glu Lys Asp Pro Thr Asn 
        275                 280                 285             


Pro Phe Arg Phe Pro Asn Ile Gly Val Glu Lys Phe Leu Glu Leu Asn 
    290                 295                 300                 


Ser Glu Gln Asn His Asp Asp Tyr Cys Leu Ala Tyr Val Phe Thr Asp 
305                 310                 315                 320 


Arg Asp Phe Asp Asp Gly Val Leu Gly Leu Ala Trp Val Gly Ala Pro 
                325                 330                 335     


Ser Gly Ser Ser Gly Gly Ile Cys Glu Lys Ser Lys Leu Tyr Ser Asp 
            340                 345                 350         


Gly Lys Lys Lys Ser Leu Asn Thr Gly Ile Ile Thr Val Gln Asn Tyr 
        355                 360                 365             


Gly Ser His Val Pro Pro Lys Val Ser His Ile Thr Phe Ala His Glu 
    370                 375                 380                 


Val Gly His Asn Phe Gly Ser Pro His Asp Ser Gly Thr Glu Cys Thr 
385                 390                 395                 400 


Pro Gly Glu Ser Lys Asn Leu Gly Gln Lys Glu Asn Gly Asn Tyr Ile 
                405                 410                 415     


Met Tyr Ala Arg Ala Thr Ser Gly Asp Lys Leu Asn Asn Asn Lys Phe 
            420                 425                 430         


Ser Leu Cys Ser Ile Arg Asn Ile Ser Gln Val Leu Glu Lys Lys Arg 
        435                 440                 445             


Asn Asn Cys Phe Val Glu Ser Gly Gln Pro Ile Cys Gly Asn Gly Met 
    450                 455                 460                 


Val Glu Gln Gly Glu Glu Cys Asp Cys Gly Tyr Ser Asp Gln Cys Lys 
465                 470                 475                 480 


Asp Glu Cys Cys Phe Asp Ala Asn Gln Pro Glu Gly Arg Lys Cys Lys 
                485                 490                 495     


Leu Lys Pro Gly Lys Gln Cys Ser Pro Ser Gln Gly Pro Cys Cys Thr 
            500                 505                 510         


Ala Gln Cys Ala Phe Lys Ser Lys Ser Glu Lys Cys Arg Asp Asp Ser 
        515                 520                 525             


Asp Cys Ala Arg Glu Gly Ile Cys Asn Gly Phe Thr Ala Leu Cys Pro 
    530                 535                 540                 


Ala Ser Asp Pro Lys Pro Asn Phe Thr Asp Cys Asn Arg His Thr Gln 
545                 550                 555                 560 


Val Cys Ile Asn Gly Gln Cys Ala Gly Ser Ile Cys Glu Lys Tyr Gly 
                565                 570                 575     


Leu Glu Glu Cys Thr Cys Ala Ser Ser Asp Gly Lys Asp Asp Lys Glu 
            580                 585                 590         


Leu Cys His Val Cys Cys Met Lys Lys Met Asp Pro Ser Thr Cys Ala 
        595                 600                 605             


Ser Thr Gly Ser Val Gln Trp Ser Arg His Phe Ser Gly Arg Thr Ile 
    610                 615                 620                 


Thr Leu Gln Pro Gly Ser Pro Cys Asn Asp Phe Arg Gly Tyr Cys Asp 
625                 630                 635                 640 


Val Phe Met Arg Cys Arg Leu Val Asp Ala Asp Gly Pro Leu Ala Arg 
                645                 650                 655     


Leu Lys Lys Ala Ile Phe Ser Pro Glu Leu Tyr Glu Asn Ile Ala Glu 
            660                 665                 670         


Trp Ile Val Ala His Trp Trp Ala Val Leu Leu Met Gly Ile Ala Leu 
        675                 680                 685             


Ile Met Leu Met Ala Gly Phe Ile Lys Ile Cys Ser Val His Thr Pro 
    690                 695                 700                 


Ser Ser Asn Pro Lys Leu Pro Pro Pro Lys Pro Leu Pro Gly Thr Leu 
705                 710                 715                 720 


Lys Arg Arg Arg Pro Pro Gln Pro Ile Gln Gln Pro Gln Arg Gln Arg 
                725                 730                 735     


Pro Arg Glu Ser Tyr Gln Met Gly His Met Arg Arg 
            740                 745             


<210>  332
<211>  58
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  332

Xaa Glu Glu Gly Ser Phe Ser His Gly Ser Val Ile Asp Gly Arg Phe 
1               5                   10                  15      


Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr Phe Tyr Val Glu Pro Ala 
            20                  25                  30          


Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro Phe His Ser Val Ile Tyr 
        35                  40                  45              


His Glu Asp Asp Ile Ser Glu Gly Leu Asn 
    50                  55              


<210>  333
<211>  71
<212>  PRT
<213>  Homo sapiens

<400>  333

Met Val Leu Leu Arg Val Leu Ile Leu Leu Leu Ser Trp Ala Ala Gly 
1               5                   10                  15      


Met Gly Asp Arg Asp Phe Asp Asp Gly Val Leu Gly Leu Ala Trp Val 
            20                  25                  30          


Gly Ala Pro Ser Gly Ser Ser Gly Gly Ile Cys Glu Lys Ser Lys Leu 
        35                  40                  45              


Tyr Ser Asp Val Pro Thr Met Gly Lys Leu His Ser Lys Glu Lys Pro 
    50                  55                  60                  


Ile Lys Ser Ser Ser Pro Asn 
65                  70      


<210>  334
<211>  125
<212>  PRT
<213>  Homo sapiens

<400>  334

Met Val Leu Leu Arg Val Leu Ile Leu Leu Leu Ser Trp Ala Ala Gly 
1               5                   10                  15      


Met Gly Gly Gln Tyr Gly Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr 
            20                  25                  30          


Glu Gly Leu Ser Tyr Asn Val Asp Ser Leu His Gln Lys His Gln Arg 
        35                  40                  45              


Ala Lys Arg Ala Val Ser His Glu Asp Gln Phe Leu Arg Leu Asp Phe 
    50                  55                  60                  


His Ala His Gly Arg His Phe Asn Leu Arg Met Lys Arg Asp Thr Ser 
65                  70                  75                  80  


Leu Phe Ser Asp Glu Phe Lys Val Glu Thr Ser Asn Lys Val Leu Asp 
                85                  90                  95      


Tyr Asp Thr Ser His Ile Tyr Thr Gly His Ile Tyr Asp Tyr Pro His 
            100                 105                 110         


Lys Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val 
        115                 120                 125 


<210>  335
<211>  59
<212>  PRT
<213>  Homo sapiens

<400>  335

Met Val Leu Leu Arg Val Leu Ile Leu Leu Leu Ser Trp Ala Ala Gly 
1               5                   10                  15      


Met Gly Ala Pro Ala Arg Trp Arg Ile Pro Lys Ser Ser Pro Pro Pro 
            20                  25                  30          


Arg Pro Ala Ala Gln Thr Arg Gly Lys Leu Cys Cys Leu Gln Leu Gly 
        35                  40                  45              


Ser Cys Ile Val Leu Tyr Pro Ala Arg Arg Ser 
    50                  55                  


<210>  336
<211>  115
<212>  PRT
<213>  Homo sapiens

<400>  336

Met Val Leu Leu Arg Val Leu Ile Leu Leu Leu Ser Trp Ala Ala Gly 
1               5                   10                  15      


Met Gly Gly Gln Tyr Gly Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr 
            20                  25                  30          


Glu Gly Leu Ser Tyr Asn Val Asp Ser Leu His Gln Lys His Gln Arg 
        35                  40                  45              


Ala Lys Arg Ala Val Ser His Glu Asp Gln Phe Leu Arg Leu Asp Phe 
    50                  55                  60                  


His Ala His Gly Arg Asp Gly Val Leu Pro Cys Cys Pro Gly Trp Ser 
65                  70                  75                  80  


Gln Thr Pro Gly Leu Lys Arg Ser Thr Cys Leu Ser Leu Pro Gln Cys 
                85                  90                  95      


Trp Asp Tyr Arg Cys Glu Pro Ser Pro Met Ile Ser Val Phe Asp Tyr 
            100                 105                 110         


Pro His Lys 
        115 


<210>  337
<211>  148
<212>  PRT
<213>  Homo sapiens

<400>  337

Met Val Leu Leu Arg Val Leu Ile Leu Leu Leu Ser Trp Ala Ala Gly 
1               5                   10                  15      


Met Gly Asp Arg Asp Phe Asp Asp Gly Val Leu Gly Leu Ala Trp Val 
            20                  25                  30          


Gly Ala Pro Ser Gly Ser Ser Gly Gly Ile Cys Glu Lys Ser Lys Leu 
        35                  40                  45              


Tyr Ser Asp Gly Lys Lys Lys Ser Leu Asn Thr Gly Ile Ile Thr Val 
    50                  55                  60                  


Gln Asn Tyr Gly Ser His Val Pro Pro Lys Val Ser His Ile Thr Phe 
65                  70                  75                  80  


Ala His Glu Val Gly His Asn Phe Gly Ser Pro His Asp Ser Gly Thr 
                85                  90                  95      


Glu Cys Thr Pro Gly Glu Ser Lys Asn Leu Gly Gln Lys Glu Asn Gly 
            100                 105                 110         


Asn Tyr Ile Met Tyr Ala Arg Ala Thr Ser Gly Asp Lys Leu Asn Asn 
        115                 120                 125             


Asn Lys Phe Ser Leu Cys Ser Ile Arg Asn Ile Ser Gln Val Leu Glu 
    130                 135                 140                 


Lys Lys Arg Asn 
145             


<210>  338
<211>  38
<212>  PRT
<213>  Homo sapiens

<400>  338

Met Val Leu Leu Arg Val Leu Ile Leu Leu Leu Ser Trp Ala Ala Gly 
1               5                   10                  15      


Met Gly Val Pro Thr Met Gly Lys Leu His Ser Lys Glu Lys Pro Ile 
            20                  25                  30          


Lys Ser Ser Ser Pro Asn 
        35              


<210>  339
<211>  452
<212>  PRT
<213>  Homo sapiens

<400>  339

Met Thr Leu Val Ser Gly Trp Leu Leu Tyr Gly Trp Ile Ile Ala Val 
1               5                   10                  15      


Gln Thr Lys Thr Lys Lys Thr Leu Ala Lys Pro Asn Ile Arg Asn Val 
            20                  25                  30          


Val Val Val Asp Gly Val Arg Thr Pro Phe Leu Leu Ser Gly Thr Ser 
        35                  40                  45              


Tyr Lys Asp Leu Met Pro His Asp Leu Ala Arg Ala Ala Leu Thr Gly 
    50                  55                  60                  


Leu Leu His Arg Thr Ser Val Pro Lys Glu Val Val Asp Tyr Ile Ile 
65                  70                  75                  80  


Phe Gly Thr Val Ile Gln Glu Val Lys Thr Ser Asn Val Ala Arg Glu 
                85                  90                  95      


Ala Ala Leu Gly Ala Gly Phe Ser Asp Lys Thr Pro Ala His Thr Val 
            100                 105                 110         


Thr Met Ala Cys Ile Ser Ala Asn Gln Ala Met Thr Thr Gly Val Gly 
        115                 120                 125             


Leu Ile Ala Ser Gly Gln Cys Asp Val Ile Val Ala Gly Gly Val Glu 
    130                 135                 140                 


Leu Met Ser Asp Val Pro Ile Arg His Ser Arg Lys Met Arg Lys Leu 
145                 150                 155                 160 


Met Leu Asp Leu Asn Lys Ala Lys Ser Met Gly Gln Arg Leu Ser Leu 
                165                 170                 175     


Ile Ser Lys Phe Arg Phe Asn Phe Leu Ala Pro Glu Leu Pro Ala Val 
            180                 185                 190         


Ser Glu Phe Ser Thr Ser Glu Thr Met Gly His Ser Ala Asp Arg Leu 
        195                 200                 205             


Ala Ala Ala Phe Ala Val Ser Arg Leu Glu Gln Asp Glu Tyr Ala Leu 
    210                 215                 220                 


Arg Ser His Ser Leu Ala Lys Lys Ala Gln Asp Glu Gly Leu Leu Ser 
225                 230                 235                 240 


Asp Val Val Pro Phe Lys Val Pro Gly Lys Asp Thr Val Thr Lys Asp 
                245                 250                 255     


Asn Gly Ile Arg Pro Ser Ser Leu Glu Gln Met Ala Lys Leu Lys Pro 
            260                 265                 270         


Ala Phe Ile Lys Pro Tyr Gly Thr Val Thr Ala Ala Asn Ser Ser Phe 
        275                 280                 285             


Leu Thr Asp Gly Ala Ser Ala Met Leu Ile Met Ala Glu Glu Lys Ala 
    290                 295                 300                 


Leu Ala Met Gly Tyr Lys Pro Lys Ala Tyr Leu Arg Asp Phe Met Tyr 
305                 310                 315                 320 


Val Ser Gln Asp Pro Lys Asp Gln Leu Leu Leu Gly Pro Thr Tyr Ala 
                325                 330                 335     


Thr Pro Lys Val Leu Glu Lys Ala Gly Leu Thr Met Asn Asp Ile Asp 
            340                 345                 350         


Ala Phe Glu Phe His Glu Ala Phe Ser Gly Gln Ile Leu Ala Asn Phe 
        355                 360                 365             


Lys Ala Met Asp Ser Asp Trp Phe Ala Glu Asn Tyr Met Gly Arg Lys 
    370                 375                 380                 


Thr Lys Val Gly Leu Pro Pro Leu Glu Lys Phe Asn Asn Trp Gly Gly 
385                 390                 395                 400 


Ser Leu Ser Leu Gly His Pro Phe Gly Ala Thr Gly Cys Arg Leu Val 
                405                 410                 415     


Met Ala Ala Ala Asn Arg Leu Arg Lys Glu Gly Gly Gln Tyr Gly Leu 
            420                 425                 430         


Val Ala Ala Cys Ala Ala Gly Gly Gln Gly His Ala Met Ile Val Glu 
        435                 440                 445             


Ala Tyr Pro Lys 
    450         


<210>  340
<211>  260
<212>  PRT
<213>  Homo sapiens

<400>  340

Met Ala Arg Pro His Pro Trp Trp Leu Cys Val Leu Gly Thr Leu Val 
1               5                   10                  15      


Gly Leu Ser Ala Thr Pro Ala Pro Lys Ser Cys Pro Glu Arg His Tyr 
            20                  25                  30          


Trp Ala Gln Gly Lys Leu Cys Cys Gln Met Cys Glu Pro Gly Thr Phe 
        35                  40                  45              


Leu Val Lys Asp Cys Asp Gln His Arg Lys Ala Ala Gln Cys Asp Pro 
    50                  55                  60                  


Cys Ile Pro Gly Val Ser Phe Ser Pro Asp His His Thr Arg Pro His 
65                  70                  75                  80  


Cys Glu Ser Cys Arg His Cys Asn Ser Gly Leu Leu Val Arg Asn Cys 
                85                  90                  95      


Thr Ile Thr Ala Asn Ala Glu Cys Ala Cys Arg Asn Gly Trp Gln Cys 
            100                 105                 110         


Arg Asp Lys Glu Cys Thr Glu Cys Asp Pro Leu Pro Asn Pro Ser Leu 
        115                 120                 125             


Thr Ala Arg Ser Ser Gln Ala Leu Ser Pro His Pro Gln Pro Thr His 
    130                 135                 140                 


Leu Pro Tyr Val Ser Glu Met Leu Glu Ala Arg Thr Ala Gly His Met 
145                 150                 155                 160 


Gln Thr Leu Ala Asp Phe Arg Gln Leu Pro Ala Arg Thr Leu Ser Thr 
                165                 170                 175     


His Trp Pro Pro Gln Arg Ser Leu Cys Ser Ser Asp Phe Ile Arg Ile 
            180                 185                 190         


Leu Val Ile Phe Ser Gly Met Phe Leu Val Phe Thr Leu Ala Gly Ala 
        195                 200                 205             


Leu Phe Leu His Gln Arg Arg Lys Tyr Arg Ser Asn Lys Gly Glu Ser 
    210                 215                 220                 


Pro Val Glu Pro Ala Glu Pro Cys His Tyr Ser Cys Pro Arg Glu Glu 
225                 230                 235                 240 


Glu Gly Ser Thr Ile Pro Ile Gln Glu Asp Tyr Arg Lys Pro Glu Pro 
                245                 250                 255     


Ala Cys Ser Pro 
            260 


<210>  341
<211>  819
<212>  PRT
<213>  Homo sapiens

<400>  341

Met Trp Gly Leu Val Arg Leu Leu Leu Ala Trp Leu Gly Gly Trp Gly 
1               5                   10                  15      


Cys Met Gly Arg Leu Ala Ala Pro Ala Arg Ala Trp Ala Gly Ser Arg 
            20                  25                  30          


Glu His Pro Gly Pro Ala Leu Leu Arg Thr Arg Arg Ser Trp Val Trp 
        35                  40                  45              


Asn Gln Phe Phe Val Ile Glu Glu Tyr Ala Gly Pro Glu Pro Val Leu 
    50                  55                  60                  


Ile Gly Lys Leu His Ser Asp Val Asp Arg Gly Glu Gly Arg Thr Lys 
65                  70                  75                  80  


Tyr Leu Leu Thr Gly Glu Gly Ala Gly Thr Val Phe Val Ile Asp Glu 
                85                  90                  95      


Ala Thr Gly Asn Ile His Val Thr Lys Ser Leu Asp Arg Glu Glu Lys 
            100                 105                 110         


Ala Gln Tyr Val Leu Leu Ala Gln Ala Val Asp Arg Ala Ser Asn Arg 
        115                 120                 125             


Pro Leu Glu Pro Pro Ser Glu Phe Ile Ile Lys Val Gln Asp Ile Asn 
    130                 135                 140                 


Asp Asn Pro Pro Ile Phe Pro Leu Gly Pro Tyr His Ala Thr Val Pro 
145                 150                 155                 160 


Glu Met Ser Asn Val Gly Thr Ser Val Ile Gln Val Thr Ala His Asp 
                165                 170                 175     


Ala Asp Asp Pro Ser Tyr Gly Asn Ser Ala Lys Leu Val Tyr Thr Val 
            180                 185                 190         


Leu Asp Gly Leu Pro Phe Phe Ser Val Asp Pro Gln Thr Gly Val Val 
        195                 200                 205             


Arg Thr Ala Ile Pro Asn Met Asp Arg Glu Thr Gln Glu Glu Phe Leu 
    210                 215                 220                 


Val Val Ile Gln Ala Lys Asp Met Gly Gly His Met Gly Gly Leu Ser 
225                 230                 235                 240 


Gly Ser Thr Thr Val Thr Val Thr Leu Ser Asp Val Asn Asp Asn Pro 
                245                 250                 255     


Pro Lys Phe Pro Gln Ser Leu Tyr Gln Phe Ser Val Val Glu Thr Ala 
            260                 265                 270         


Gly Pro Gly Thr Leu Val Gly Arg Leu Arg Ala Gln Asp Pro Asp Leu 
        275                 280                 285             


Gly Asp Asn Ala Leu Met Ala Tyr Ser Ile Leu Asp Gly Glu Gly Ser 
    290                 295                 300                 


Glu Ala Phe Ser Ile Ser Thr Asp Leu Gln Gly Arg Asp Gly Leu Leu 
305                 310                 315                 320 


Thr Val Arg Lys Pro Leu Asp Phe Glu Ser Gln Arg Ser Tyr Ser Phe 
                325                 330                 335     


Arg Val Glu Ala Thr Asn Thr Leu Ile Asp Pro Ala Tyr Leu Arg Arg 
            340                 345                 350         


Gly Pro Phe Lys Asp Val Ala Ser Val Arg Val Ala Val Gln Asp Ala 
        355                 360                 365             


Pro Glu Pro Pro Ala Phe Thr Gln Ala Ala Tyr His Leu Thr Val Pro 
    370                 375                 380                 


Glu Asn Lys Ala Pro Gly Thr Leu Val Gly Gln Ile Ser Ala Ala Asp 
385                 390                 395                 400 


Leu Asp Ser Pro Ala Ser Pro Ile Arg Tyr Ser Ile Leu Pro His Ser 
                405                 410                 415     


Asp Pro Glu Arg Cys Phe Ser Ile Gln Pro Glu Glu Gly Thr Ile His 
            420                 425                 430         


Thr Ala Ala Pro Leu Asp Arg Glu Ala Arg Ala Trp His Asn Leu Thr 
        435                 440                 445             


Val Leu Ala Thr Glu Leu Gly Trp Ser Trp Gly Pro Glu Arg Gly Trp 
    450                 455                 460                 


Val Pro Leu Leu Val Ala Glu Trp Ser Ala Pro Ala Ala Pro Pro Gln 
465                 470                 475                 480 


Arg Ser Pro Val Gly Ser Ala Val Gly Ile Pro Gln Asp Ser Ser Ala 
                485                 490                 495     


Gln Ala Ser Arg Val Gln Val Ala Ile Gln Thr Leu Asp Glu Asn Asp 
            500                 505                 510         


Asn Ala Pro Gln Leu Ala Glu Pro Tyr Asp Thr Phe Val Cys Asp Ser 
        515                 520                 525             


Ala Ala Pro Gly Gln Leu Ile Gln Val Ile Arg Ala Leu Asp Arg Asp 
    530                 535                 540                 


Glu Val Gly Asn Ser Ser His Val Ser Phe Gln Gly Pro Leu Gly Pro 
545                 550                 555                 560 


Asp Ala Asn Phe Thr Val Gln Asp Asn Arg Asp Gly Ser Ala Ser Leu 
                565                 570                 575     


Leu Leu Pro Ser Arg Pro Ala Pro Pro Arg His Ala Pro Tyr Leu Val 
            580                 585                 590         


Pro Ile Glu Leu Trp Asp Trp Gly Gln Pro Ala Leu Ser Ser Thr Ala 
        595                 600                 605             


Thr Val Thr Val Ser Val Cys Arg Cys Gln Pro Asp Gly Ser Val Ala 
    610                 615                 620                 


Ser Cys Trp Pro Glu Ala His Leu Ser Ala Ala Gly Leu Ser Thr Gly 
625                 630                 635                 640 


Ala Leu Leu Ala Ile Ile Thr Cys Val Gly Ala Leu Leu Ala Leu Val 
                645                 650                 655     


Val Leu Phe Val Ala Leu Arg Arg Gln Lys Gln Glu Ala Leu Met Val 
            660                 665                 670         


Leu Glu Glu Glu Asp Val Arg Glu Asn Ile Ile Thr Tyr Asp Asp Glu 
        675                 680                 685             


Gly Gly Gly Glu Glu Asp Thr Glu Ala Phe Asp Ile Thr Ala Leu Gln 
    690                 695                 700                 


Asn Pro Asp Gly Ala Ala Pro Pro Ala Pro Gly Pro Pro Ala Arg Arg 
705                 710                 715                 720 


Asp Val Leu Pro Arg Ala Arg Val Ser Arg Gln Pro Arg Pro Pro Gly 
                725                 730                 735     


Pro Ala Asp Val Ala Gln Leu Leu Ala Leu Arg Leu Arg Glu Ala Asp 
            740                 745                 750         


Glu Asp Pro Gly Val Pro Pro Tyr Asp Ser Val Gln Val Tyr Gly Tyr 
        755                 760                 765             


Glu Gly Arg Gly Ser Ser Cys Gly Ser Leu Ser Ser Leu Gly Ser Gly 
    770                 775                 780                 


Ser Glu Ala Gly Gly Ala Pro Gly Pro Ala Glu Pro Leu Asp Asp Trp 
785                 790                 795                 800 


Gly Pro Leu Phe Arg Thr Leu Ala Glu Leu Tyr Gly Ala Lys Glu Pro 
                805                 810                 815     


Pro Ala Pro 
            


<210>  342
<211>  819
<212>  PRT
<213>  Homo sapiens

<400>  342

Met Trp Gly Leu Val Arg Leu Leu Leu Ala Trp Leu Gly Gly Trp Gly 
1               5                   10                  15      


Cys Met Gly Arg Leu Ala Ala Pro Ala Arg Ala Trp Ala Gly Ser Arg 
            20                  25                  30          


Glu His Pro Gly Pro Ala Leu Leu Arg Thr Arg Arg Ser Trp Val Trp 
        35                  40                  45              


Asn Gln Phe Phe Val Ile Glu Glu Tyr Ala Gly Pro Glu Pro Val Leu 
    50                  55                  60                  


Ile Gly Lys Leu His Ser Asp Val Asp Arg Gly Glu Gly Arg Thr Lys 
65                  70                  75                  80  


Tyr Leu Leu Thr Gly Glu Gly Ala Gly Thr Val Phe Val Ile Asp Glu 
                85                  90                  95      


Ala Thr Gly Asn Ile His Val Thr Lys Ser Leu Asp Arg Glu Glu Lys 
            100                 105                 110         


Ala Gln Tyr Val Leu Leu Ala Gln Ala Val Asp Arg Ala Ser Asn Arg 
        115                 120                 125             


Pro Leu Glu Pro Pro Ser Glu Phe Ile Ile Lys Val Gln Asp Ile Asn 
    130                 135                 140                 


Asp Asn Pro Pro Ile Phe Pro Leu Gly Pro Tyr His Ala Thr Val Pro 
145                 150                 155                 160 


Glu Met Ser Asn Val Gly Thr Ser Val Ile Gln Val Thr Ala His Asp 
                165                 170                 175     


Ala Asp Asp Pro Ser Tyr Gly Asn Ser Ala Lys Leu Val Tyr Thr Val 
            180                 185                 190         


Leu Asp Gly Leu Pro Phe Phe Ser Val Asp Pro Gln Thr Gly Val Val 
        195                 200                 205             


Arg Thr Ala Ile Pro Asn Met Asp Arg Glu Thr Gln Glu Glu Phe Leu 
    210                 215                 220                 


Val Val Ile Gln Ala Lys Asp Met Gly Gly His Met Gly Gly Leu Ser 
225                 230                 235                 240 


Gly Ser Thr Thr Val Thr Val Thr Leu Ser Asp Val Asn Asp Asn Pro 
                245                 250                 255     


Pro Lys Phe Pro Gln Ser Leu Tyr Gln Phe Ser Val Val Glu Thr Ala 
            260                 265                 270         


Gly Pro Gly Thr Leu Val Gly Arg Leu Arg Ala Gln Asp Pro Asp Leu 
        275                 280                 285             


Gly Asp Asn Ala Leu Met Ala Tyr Ser Ile Leu Asp Gly Glu Gly Ser 
    290                 295                 300                 


Glu Ala Phe Ser Ile Ser Thr Asp Leu Gln Gly Arg Asp Gly Leu Leu 
305                 310                 315                 320 


Thr Val Arg Lys Pro Leu Asp Phe Glu Ser Gln Arg Ser Tyr Ser Phe 
                325                 330                 335     


Arg Val Glu Ala Thr Asn Thr Leu Ile Asp Pro Ala Tyr Leu Arg Arg 
            340                 345                 350         


Gly Pro Phe Lys Asp Val Ala Ser Val Arg Val Ala Val Gln Asp Ala 
        355                 360                 365             


Pro Glu Pro Pro Ala Phe Thr Gln Ala Ala Tyr His Leu Thr Val Pro 
    370                 375                 380                 


Glu Asn Lys Ala Pro Gly Thr Leu Val Gly Gln Ile Ser Ala Ala Asp 
385                 390                 395                 400 


Leu Asp Ser Pro Ala Ser Pro Ile Arg Tyr Ser Ile Leu Pro His Ser 
                405                 410                 415     


Asp Pro Glu Arg Cys Phe Ser Ile Gln Pro Glu Glu Gly Thr Ile His 
            420                 425                 430         


Thr Ala Ala Pro Leu Asp Arg Glu Ala Arg Ala Trp His Asn Leu Thr 
        435                 440                 445             


Val Leu Ala Thr Glu Leu Gly Trp Ser Trp Gly Pro Glu Arg Gly Trp 
    450                 455                 460                 


Val Pro Leu Leu Val Ala Glu Trp Ser Ala Pro Ala Ala Pro Pro Gln 
465                 470                 475                 480 


Arg Ser Pro Val Gly Ser Ala Val Gly Ile Pro Gln Asp Ser Ser Ala 
                485                 490                 495     


Gln Ala Ser Arg Val Gln Val Ala Ile Gln Thr Leu Asp Glu Asn Asp 
            500                 505                 510         


Asn Ala Pro Gln Leu Ala Glu Pro Tyr Asp Thr Phe Val Cys Asp Ser 
        515                 520                 525             


Ala Ala Pro Gly Gln Leu Ile Gln Val Ile Arg Ala Leu Asp Arg Asp 
    530                 535                 540                 


Glu Val Gly Asn Ser Ser His Val Ser Phe Gln Gly Pro Leu Gly Pro 
545                 550                 555                 560 


Asp Ala Asn Phe Thr Val Gln Asp Asn Arg Asp Gly Ser Ala Ser Leu 
                565                 570                 575     


Leu Leu Pro Ser Arg Pro Ala Pro Pro Arg His Ala Pro Tyr Leu Val 
            580                 585                 590         


Pro Ile Glu Leu Trp Asp Trp Gly Gln Pro Ala Leu Ser Ser Thr Ala 
        595                 600                 605             


Thr Val Thr Val Ser Val Cys Arg Cys Gln Pro Asp Gly Ser Val Ala 
    610                 615                 620                 


Ser Cys Trp Pro Glu Ala His Leu Ser Ala Ala Gly Leu Ser Thr Gly 
625                 630                 635                 640 


Ala Leu Leu Ala Ile Ile Thr Cys Val Gly Ala Leu Leu Ala Leu Val 
                645                 650                 655     


Val Leu Phe Val Ala Leu Arg Arg Gln Lys Gln Glu Ala Leu Met Val 
            660                 665                 670         


Leu Glu Glu Glu Asp Val Arg Glu Asn Ile Ile Thr Tyr Asp Asp Glu 
        675                 680                 685             


Gly Gly Gly Glu Glu Asp Thr Glu Ala Phe Asp Ile Thr Ala Leu Gln 
    690                 695                 700                 


Asn Pro Asp Gly Ala Ala Pro Pro Ala Pro Gly Pro Pro Ala Arg Arg 
705                 710                 715                 720 


Asp Val Leu Pro Arg Ala Arg Val Ser Arg Gln Pro Arg Pro Pro Gly 
                725                 730                 735     


Pro Ala Asp Val Ala Gln Leu Leu Ala Leu Arg Leu Arg Glu Ala Asp 
            740                 745                 750         


Glu Asp Pro Gly Val Pro Pro Tyr Asp Ser Val Gln Val Tyr Gly Tyr 
        755                 760                 765             


Glu Gly Arg Gly Ser Ser Cys Gly Ser Leu Ser Ser Leu Gly Ser Gly 
    770                 775                 780                 


Ser Glu Ala Gly Gly Ala Pro Gly Pro Ala Glu Pro Leu Asp Asp Trp 
785                 790                 795                 800 


Gly Pro Leu Phe Arg Thr Leu Ala Glu Leu Tyr Gly Ala Lys Glu Pro 
                805                 810                 815     


Pro Ala Pro 
            


<210>  343
<211>  781
<212>  PRT
<213>  Homo sapiens

<400>  343

Met Trp Gly Leu Val Arg Leu Leu Leu Ala Trp Leu Gly Gly Trp Gly 
1               5                   10                  15      


Cys Met Gly Arg Leu Ala Ala Pro Ala Arg Ala Trp Ala Gly Ser Arg 
            20                  25                  30          


Glu His Pro Gly Pro Ala Leu Leu Arg Thr Arg Arg Ser Trp Val Trp 
        35                  40                  45              


Asn Gln Phe Phe Val Ile Glu Glu Tyr Ala Gly Pro Glu Pro Val Leu 
    50                  55                  60                  


Ile Gly Lys Leu His Ser Asp Val Asp Arg Gly Glu Gly Arg Thr Lys 
65                  70                  75                  80  


Tyr Leu Leu Thr Gly Glu Gly Ala Gly Thr Val Phe Val Ile Asp Glu 
                85                  90                  95      


Ala Thr Gly Asn Ile His Val Thr Lys Ser Leu Asp Arg Glu Glu Lys 
            100                 105                 110         


Ala Gln Tyr Val Leu Leu Ala Gln Ala Val Asp Arg Ala Ser Asn Arg 
        115                 120                 125             


Pro Leu Glu Pro Pro Ser Glu Phe Ile Ile Lys Val Gln Asp Ile Asn 
    130                 135                 140                 


Asp Asn Pro Pro Ile Phe Pro Leu Gly Pro Tyr His Ala Thr Val Pro 
145                 150                 155                 160 


Glu Met Ser Asn Val Gly Thr Ser Val Ile Gln Val Thr Ala His Asp 
                165                 170                 175     


Ala Asp Asp Pro Ser Tyr Gly Asn Ser Ala Lys Leu Val Tyr Thr Val 
            180                 185                 190         


Leu Asp Gly Leu Pro Phe Phe Ser Val Asp Pro Gln Thr Gly Val Val 
        195                 200                 205             


Arg Thr Ala Ile Pro Asn Met Asp Arg Glu Thr Gln Glu Glu Phe Leu 
    210                 215                 220                 


Val Val Ile Gln Ala Lys Asp Met Gly Gly His Met Gly Gly Leu Ser 
225                 230                 235                 240 


Gly Ser Thr Thr Val Thr Val Thr Leu Ser Asp Val Asn Asp Asn Pro 
                245                 250                 255     


Pro Lys Phe Pro Gln Ser Leu Tyr Gln Phe Ser Val Val Glu Thr Ala 
            260                 265                 270         


Gly Pro Gly Thr Leu Val Gly Arg Leu Arg Ala Gln Asp Pro Asp Leu 
        275                 280                 285             


Gly Asp Asn Ala Leu Met Ala Tyr Ser Ile Leu Asp Gly Glu Gly Ser 
    290                 295                 300                 


Glu Ala Phe Ser Ile Ser Thr Asp Leu Gln Gly Arg Asp Gly Leu Leu 
305                 310                 315                 320 


Thr Val Arg Lys Pro Leu Asp Phe Glu Ser Gln Arg Ser Tyr Ser Phe 
                325                 330                 335     


Arg Val Glu Ala Thr Asn Thr Leu Ile Asp Pro Ala Tyr Leu Arg Arg 
            340                 345                 350         


Gly Pro Phe Lys Asp Val Ala Ser Val Arg Val Ala Val Gln Asp Ala 
        355                 360                 365             


Pro Glu Pro Pro Ala Phe Thr Gln Ala Ala Tyr His Leu Thr Val Pro 
    370                 375                 380                 


Glu Asn Lys Ala Pro Gly Thr Leu Val Gly Gln Ile Ser Ala Ala Asp 
385                 390                 395                 400 


Leu Asp Ser Pro Ala Ser Pro Ile Arg Tyr Ser Ile Leu Pro His Ser 
                405                 410                 415     


Asp Pro Glu Arg Cys Phe Ser Ile Gln Pro Glu Glu Gly Thr Ile His 
            420                 425                 430         


Thr Ala Ala Pro Leu Asp Arg Glu Ala Arg Ala Trp His Asn Leu Thr 
        435                 440                 445             


Val Leu Ala Thr Glu Leu Asp Ser Ser Ala Gln Ala Ser Arg Val Gln 
    450                 455                 460                 


Val Ala Ile Gln Thr Leu Asp Glu Asn Asp Asn Ala Pro Gln Leu Ala 
465                 470                 475                 480 


Glu Pro Tyr Asp Thr Phe Val Cys Asp Ser Ala Ala Pro Gly Gln Leu 
                485                 490                 495     


Ile Gln Val Ile Arg Ala Leu Asp Arg Asp Glu Val Gly Asn Ser Ser 
            500                 505                 510         


His Val Ser Phe Gln Gly Pro Leu Gly Pro Asp Ala Asn Phe Thr Val 
        515                 520                 525             


Gln Asp Asn Arg Asp Gly Ser Ala Ser Leu Leu Leu Pro Ser Arg Pro 
    530                 535                 540                 


Ala Pro Pro Arg His Ala Pro Tyr Leu Val Pro Ile Glu Leu Trp Asp 
545                 550                 555                 560 


Trp Gly Gln Pro Ala Leu Ser Ser Thr Ala Thr Val Thr Val Ser Val 
                565                 570                 575     


Cys Arg Cys Gln Pro Asp Gly Ser Val Ala Ser Cys Trp Pro Glu Ala 
            580                 585                 590         


His Leu Ser Ala Ala Gly Leu Ser Thr Gly Ala Leu Leu Ala Ile Ile 
        595                 600                 605             


Thr Cys Val Gly Ala Leu Leu Ala Leu Val Val Leu Phe Val Ala Leu 
    610                 615                 620                 


Arg Arg Gln Lys Gln Glu Ala Leu Met Val Leu Glu Glu Glu Asp Val 
625                 630                 635                 640 


Arg Glu Asn Ile Ile Thr Tyr Asp Asp Glu Gly Gly Gly Glu Glu Asp 
                645                 650                 655     


Thr Glu Ala Phe Asp Ile Thr Ala Leu Gln Asn Pro Asp Gly Ala Ala 
            660                 665                 670         


Pro Pro Ala Pro Gly Pro Pro Ala Arg Arg Asp Val Leu Pro Arg Ala 
        675                 680                 685             


Arg Val Ser Arg Gln Pro Arg Pro Pro Gly Pro Ala Asp Val Ala Gln 
    690                 695                 700                 


Leu Leu Ala Leu Arg Leu Arg Glu Ala Asp Glu Asp Pro Gly Val Pro 
705                 710                 715                 720 


Pro Tyr Asp Ser Val Gln Val Tyr Gly Tyr Glu Gly Arg Gly Ser Ser 
                725                 730                 735     


Cys Gly Ser Leu Ser Ser Leu Gly Ser Gly Ser Glu Ala Gly Gly Ala 
            740                 745                 750         


Pro Gly Pro Ala Glu Pro Leu Asp Asp Trp Gly Pro Leu Phe Arg Thr 
        755                 760                 765             


Leu Ala Glu Leu Tyr Gly Ala Lys Glu Pro Pro Ala Pro 
    770                 775                 780     


<210>  344
<211>  781
<212>  PRT
<213>  Homo sapiens

<400>  344

Met Trp Gly Leu Val Arg Leu Leu Leu Ala Trp Leu Gly Gly Trp Gly 
1               5                   10                  15      


Cys Met Gly Arg Leu Ala Ala Pro Ala Arg Ala Trp Ala Gly Ser Arg 
            20                  25                  30          


Glu His Pro Gly Pro Ala Leu Leu Arg Thr Arg Arg Ser Trp Val Trp 
        35                  40                  45              


Asn Gln Phe Phe Val Ile Glu Glu Tyr Ala Gly Pro Glu Pro Val Leu 
    50                  55                  60                  


Ile Gly Lys Leu His Ser Asp Val Asp Arg Gly Glu Gly Arg Thr Lys 
65                  70                  75                  80  


Tyr Leu Leu Thr Gly Glu Gly Ala Gly Thr Val Phe Val Ile Asp Glu 
                85                  90                  95      


Ala Thr Gly Asn Ile His Val Thr Lys Ser Leu Asp Arg Glu Glu Lys 
            100                 105                 110         


Ala Gln Tyr Val Leu Leu Ala Gln Ala Val Asp Arg Ala Ser Asn Arg 
        115                 120                 125             


Pro Leu Glu Pro Pro Ser Glu Phe Ile Ile Lys Val Gln Asp Ile Asn 
    130                 135                 140                 


Asp Asn Pro Pro Ile Phe Pro Leu Gly Pro Tyr His Ala Thr Val Pro 
145                 150                 155                 160 


Glu Met Ser Asn Val Gly Thr Ser Val Ile Gln Val Thr Ala His Asp 
                165                 170                 175     


Ala Asp Asp Pro Ser Tyr Gly Asn Ser Ala Lys Leu Val Tyr Thr Val 
            180                 185                 190         


Leu Asp Gly Leu Pro Phe Phe Ser Val Asp Pro Gln Thr Gly Val Val 
        195                 200                 205             


Arg Thr Ala Ile Pro Asn Met Asp Arg Glu Thr Gln Glu Glu Phe Leu 
    210                 215                 220                 


Val Val Ile Gln Ala Lys Asp Met Gly Gly His Met Gly Gly Leu Ser 
225                 230                 235                 240 


Gly Ser Thr Thr Val Thr Val Thr Leu Ser Asp Val Asn Asp Asn Pro 
                245                 250                 255     


Pro Lys Phe Pro Gln Ser Leu Tyr Gln Phe Ser Val Val Glu Thr Ala 
            260                 265                 270         


Gly Pro Gly Thr Leu Val Gly Arg Leu Arg Ala Gln Asp Pro Asp Leu 
        275                 280                 285             


Gly Asp Asn Ala Leu Met Ala Tyr Ser Ile Leu Asp Gly Glu Gly Ser 
    290                 295                 300                 


Glu Ala Phe Ser Ile Ser Thr Asp Leu Gln Gly Arg Asp Gly Leu Leu 
305                 310                 315                 320 


Thr Val Arg Lys Pro Leu Asp Phe Glu Ser Gln Arg Ser Tyr Ser Phe 
                325                 330                 335     


Arg Val Glu Ala Thr Asn Thr Leu Ile Asp Pro Ala Tyr Leu Arg Arg 
            340                 345                 350         


Gly Pro Phe Lys Asp Val Ala Ser Val Arg Val Ala Val Gln Asp Ala 
        355                 360                 365             


Pro Glu Pro Pro Ala Phe Thr Gln Ala Ala Tyr His Leu Thr Val Pro 
    370                 375                 380                 


Glu Asn Lys Ala Pro Gly Thr Leu Val Gly Gln Ile Ser Ala Ala Asp 
385                 390                 395                 400 


Leu Asp Ser Pro Ala Ser Pro Ile Arg Tyr Ser Ile Leu Pro His Ser 
                405                 410                 415     


Asp Pro Glu Arg Cys Phe Ser Ile Gln Pro Glu Glu Gly Thr Ile His 
            420                 425                 430         


Thr Ala Ala Pro Leu Asp Arg Glu Ala Arg Ala Trp His Asn Leu Thr 
        435                 440                 445             


Val Leu Ala Thr Glu Leu Asp Ser Ser Ala Gln Ala Ser Arg Val Gln 
    450                 455                 460                 


Val Ala Ile Gln Thr Leu Asp Glu Asn Asp Asn Ala Pro Gln Leu Ala 
465                 470                 475                 480 


Glu Pro Tyr Asp Thr Phe Val Cys Asp Ser Ala Ala Pro Gly Gln Leu 
                485                 490                 495     


Ile Gln Val Ile Arg Ala Leu Asp Arg Asp Glu Val Gly Asn Ser Ser 
            500                 505                 510         


His Val Ser Phe Gln Gly Pro Leu Gly Pro Asp Ala Asn Phe Thr Val 
        515                 520                 525             


Gln Asp Asn Arg Asp Gly Ser Ala Ser Leu Leu Leu Pro Ser Arg Pro 
    530                 535                 540                 


Ala Pro Pro Arg His Ala Pro Tyr Leu Val Pro Ile Glu Leu Trp Asp 
545                 550                 555                 560 


Trp Gly Gln Pro Ala Leu Ser Ser Thr Ala Thr Val Thr Val Ser Val 
                565                 570                 575     


Cys Arg Cys Gln Pro Asp Gly Ser Val Ala Ser Cys Trp Pro Glu Ala 
            580                 585                 590         


His Leu Ser Ala Ala Gly Leu Ser Thr Gly Ala Leu Leu Ala Ile Ile 
        595                 600                 605             


Thr Cys Val Gly Ala Leu Leu Ala Leu Val Val Leu Phe Val Ala Leu 
    610                 615                 620                 


Arg Arg Gln Lys Gln Glu Ala Leu Met Val Leu Glu Glu Glu Asp Val 
625                 630                 635                 640 


Arg Glu Asn Ile Ile Thr Tyr Asp Asp Glu Gly Gly Gly Glu Glu Asp 
                645                 650                 655     


Thr Glu Ala Phe Asp Ile Thr Ala Leu Gln Asn Pro Asp Gly Ala Ala 
            660                 665                 670         


Pro Pro Ala Pro Gly Pro Pro Ala Arg Arg Asp Val Leu Pro Arg Ala 
        675                 680                 685             


Arg Val Ser Arg Gln Pro Arg Pro Pro Gly Pro Ala Asp Val Ala Gln 
    690                 695                 700                 


Leu Leu Ala Leu Arg Leu Arg Glu Ala Asp Glu Asp Pro Gly Val Pro 
705                 710                 715                 720 


Pro Tyr Asp Ser Val Gln Val Tyr Gly Tyr Glu Gly Arg Gly Ser Ser 
                725                 730                 735     


Cys Gly Ser Leu Ser Ser Leu Gly Ser Gly Ser Glu Ala Gly Gly Ala 
            740                 745                 750         


Pro Gly Pro Ala Glu Pro Leu Asp Asp Trp Gly Pro Leu Phe Arg Thr 
        755                 760                 765             


Leu Ala Glu Leu Tyr Gly Ala Lys Glu Pro Pro Ala Pro 
    770                 775                 780     


<210>  345
<211>  314
<212>  PRT
<213>  Homo sapiens

<400>  345

Met Trp Gly Leu Val Arg Leu Leu Leu Ala Trp Leu Gly Gly Trp Gly 
1               5                   10                  15      


Cys Met Gly Arg Leu Ala Ala Pro Ala Arg Ala Trp Ala Gly Ser Arg 
            20                  25                  30          


Glu His Pro Gly Pro Ala Leu Leu Arg Thr Arg Arg Ser Trp Val Trp 
        35                  40                  45              


Asn Gln Phe Phe Val Ile Glu Glu Tyr Ala Gly Pro Glu Pro Val Leu 
    50                  55                  60                  


Ile Gly Lys Leu His Ser Asp Val Asp Arg Gly Glu Gly Arg Thr Lys 
65                  70                  75                  80  


Tyr Leu Leu Thr Gly Glu Gly Ala Gly Thr Val Phe Val Ile Asp Glu 
                85                  90                  95      


Ala Thr Gly Asn Ile His Val Thr Lys Ser Leu Asp Arg Glu Glu Lys 
            100                 105                 110         


Ala Gln Tyr Val Leu Leu Ala Gln Ala Val Asp Arg Ala Ser Asn Arg 
        115                 120                 125             


Pro Leu Glu Pro Pro Ser Glu Phe Ile Ile Lys Ile Ile Thr Cys Val 
    130                 135                 140                 


Gly Ala Leu Leu Ala Leu Val Val Leu Phe Val Ala Leu Arg Arg Gln 
145                 150                 155                 160 


Lys Gln Glu Ala Leu Met Val Leu Glu Glu Glu Asp Val Arg Glu Asn 
                165                 170                 175     


Ile Ile Thr Tyr Asp Asp Glu Gly Gly Gly Glu Glu Asp Thr Glu Ala 
            180                 185                 190         


Phe Asp Ile Thr Ala Leu Gln Asn Pro Asp Gly Ala Ala Pro Pro Ala 
        195                 200                 205             


Pro Gly Pro Pro Ala Arg Arg Asp Val Leu Pro Arg Ala Arg Val Ser 
    210                 215                 220                 


Arg Gln Pro Arg Pro Pro Gly Pro Ala Asp Val Ala Gln Leu Leu Ala 
225                 230                 235                 240 


Leu Arg Leu Arg Glu Ala Asp Glu Asp Pro Gly Val Pro Pro Tyr Asp 
                245                 250                 255     


Ser Val Gln Val Tyr Gly Tyr Glu Gly Arg Gly Ser Ser Cys Gly Ser 
            260                 265                 270         


Leu Ser Ser Leu Gly Ser Gly Ser Glu Ala Gly Gly Ala Pro Gly Pro 
        275                 280                 285             


Ala Glu Pro Leu Asp Asp Trp Gly Pro Leu Phe Arg Thr Leu Ala Glu 
    290                 295                 300                 


Leu Tyr Gly Ala Lys Glu Pro Pro Ala Pro 
305                 310                 


<210>  346
<211>  45
<212>  PRT
<213>  Homo sapiens

<400>  346

Met Phe Arg Ala Ala Ala Pro Gly Gln Leu Arg Arg Ala Arg Arg Gly 
1               5                   10                  15      


Phe Pro Met Leu Pro Arg Leu Val Ser Asn Ser Cys Pro Gln Val Ile 
            20                  25                  30          


His Leu Pro Arg Pro Pro Lys Val Leu Glu Leu Gln Ala 
        35                  40                  45  


<210>  347
<211>  45
<212>  PRT
<213>  Homo sapiens

<400>  347

Met Phe Arg Ala Ala Ala Pro Gly Gln Leu Arg Arg Ala Arg Arg Gly 
1               5                   10                  15      


Phe Pro Met Leu Pro Arg Leu Val Ser Asn Ser Cys Pro Gln Val Ile 
            20                  25                  30          


His Leu Pro Arg Pro Pro Lys Val Leu Glu Leu Gln Ala 
        35                  40                  45  


<210>  348
<211>  46
<212>  PRT
<213>  Homo sapiens

<400>  348

Met Asn Glu Ala Lys Val Lys Glu Thr Leu Arg Arg Cys Gly Ala Ser 
1               5                   10                  15      


Gly Asp Glu Cys Gly Arg Leu Gln Tyr Ala Leu Thr Cys Leu Arg Lys 
            20                  25                  30          


Val Thr Gly Leu Gly Gly Glu His Lys Glu Asp Ser Ser Trp 
        35                  40                  45      


<210>  349
<211>  248
<212>  PRT
<213>  Homo sapiens

<400>  349

Met Gln Thr Cys Pro Leu Ala Phe Pro Gly His Val Ser Gln Ala Leu 
1               5                   10                  15      


Gly Thr Leu Leu Phe Leu Ala Ala Ser Leu Ser Ala Gln Asn Glu Gly 
            20                  25                  30          


Trp Asp Ser Pro Ile Cys Thr Glu Gly Val Val Ser Val Ser Trp Gly 
        35                  40                  45              


Glu Asn Thr Val Met Ser Cys Asn Ile Ser Asn Ala Phe Ser His Val 
    50                  55                  60                  


Asn Ile Lys Leu Arg Ala His Gly Gln Glu Ser Ala Ile Phe Asn Glu 
65                  70                  75                  80  


Val Ala Pro Gly Tyr Phe Ser Arg Asp Gly Trp Gln Leu Gln Val Gln 
                85                  90                  95      


Gly Gly Val Ala Gln Leu Val Ile Lys Gly Ala Arg Asp Ser His Ala 
            100                 105                 110         


Gly Leu Tyr Met Trp His Leu Val Gly His Gln Arg Asn Asn Arg Gln 
        115                 120                 125             


Val Thr Leu Glu Val Ser Gly Ala Glu Pro Gln Ser Ala Pro Asp Thr 
    130                 135                 140                 


Gly Phe Trp Pro Val Pro Ala Val Val Thr Ala Val Phe Ile Leu Leu 
145                 150                 155                 160 


Val Ala Leu Val Met Phe Ala Trp Tyr Arg Cys Arg Cys Ser Gln Gln 
                165                 170                 175     


Arg Arg Glu Lys Lys Phe Phe Leu Leu Glu Pro Gln Met Lys Val Ala 
            180                 185                 190         


Ala Leu Arg Ala Gly Ala Gln Gln Gly Leu Ser Arg Ala Ser Ala Glu 
        195                 200                 205             


Leu Trp Thr Pro Asp Ser Glu Pro Thr Pro Arg Pro Leu Ala Leu Val 
    210                 215                 220                 


Phe Lys Pro Ser Pro Leu Gly Ala Leu Glu Leu Leu Ser Pro Gln Pro 
225                 230                 235                 240 


Leu Phe Pro Tyr Ala Ala Asp Pro 
                245             


<210>  350
<211>  149
<212>  PRT
<213>  Homo sapiens

<400>  350

Met Gln Thr Cys Pro Leu Ala Phe Pro Gly His Val Ser Gln Ala Leu 
1               5                   10                  15      


Gly Thr Leu Leu Phe Leu Ala Ala Ser Leu Ser Ala Gln Asn Glu Gly 
            20                  25                  30          


Trp Asp Ser Pro Ile Cys Thr Glu Gly Val Val Ser Val Ser Trp Gly 
        35                  40                  45              


Glu Asn Thr Val Met Ser Cys Asn Ile Ser Asn Ala Phe Ser His Val 
    50                  55                  60                  


Asn Ile Lys Leu Arg Ala His Gly Gln Glu Ser Ala Ile Phe Asn Glu 
65                  70                  75                  80  


Val Ala Pro Gly Tyr Phe Ser Arg Asp Gly Trp Gln Leu Gln Val Gln 
                85                  90                  95      


Gly Gly Val Ala Gln Leu Val Ile Lys Gly Ala Arg Asp Ser His Ala 
            100                 105                 110         


Gly Leu Tyr Met Trp His Leu Val Gly His Gln Arg Asn Asn Arg Gln 
        115                 120                 125             


Val Thr Leu Glu Val Ser Gly Ala Ala Val Pro Ser Asn Ala Gly Arg 
    130                 135                 140                 


Arg Ser Ser Ser Ser 
145                 


<210>  351
<211>  178
<212>  PRT
<213>  Homo sapiens

<400>  351

Met Gln Thr Cys Pro Leu Ala Phe Pro Gly His Val Ser Gln Ala Leu 
1               5                   10                  15      


Gly Thr Leu Leu Phe Leu Ala Ala Ser Leu Ser Ala Gln Asn Glu Gly 
            20                  25                  30          


Trp Asp Ser Pro Ile Cys Thr Glu Gly Val Val Ser Val Ser Trp Gly 
        35                  40                  45              


Glu Asn Thr Val Met Ser Cys Asn Ile Ser Asn Ala Phe Ser His Val 
    50                  55                  60                  


Asn Ile Lys Leu Arg Ala His Gly Gln Glu Ser Ala Ile Phe Asn Glu 
65                  70                  75                  80  


Val Ala Pro Gly Tyr Phe Ser Arg Asp Gly Trp Gln Leu Gln Val Gln 
                85                  90                  95      


Gly Gly Val Ala Gln Leu Val Ile Lys Gly Ala Arg Asp Ser His Ala 
            100                 105                 110         


Gly Leu Tyr Met Trp His Leu Val Gly His Gln Arg Asn Asn Arg Gln 
        115                 120                 125             


Val Thr Leu Glu Val Ser Gly Ala Glu Pro Gln Ser Ala Pro Asp Thr 
    130                 135                 140                 


Gly Phe Trp Pro Val Pro Ala Val Val Thr Ala Val Phe Ile Leu Leu 
145                 150                 155                 160 


Val Ala Leu Val Met Phe Ala Trp Tyr Arg Cys Arg Cys Ser Gln Gln 
                165                 170                 175     


Arg Arg 
        


<210>  352
<211>  43
<212>  PRT
<213>  Homo sapiens

<400>  352

Met Gln Thr Cys Pro Leu Ala Phe Pro Gly His Val Ser Gln Ala Leu 
1               5                   10                  15      


Gly Thr Leu Leu Phe Leu Ala Ala Ser Leu Ser Ala Gln Asn Glu Ala 
            20                  25                  30          


Ala Cys Pro Arg Ala Gly Glu Arg His Leu Gln 
        35                  40              


<210>  353
<211>  44
<212>  PRT
<213>  Homo sapiens

<400>  353

Met Gln Thr Cys Pro Leu Ala Phe Pro Gly His Val Ser Gln Ala Leu 
1               5                   10                  15      


Gly Thr Leu Leu Phe Leu Ala Ala Ser Leu Ser Ala Gln Asn Glu Gly 
            20                  25                  30          


Trp Asp Ser Pro Ile Cys Thr Glu Gly Val Val Ser 
        35                  40                  


<210>  354
<211>  85
<212>  PRT
<213>  Homo sapiens

<400>  354

Met Gln Thr Cys Pro Leu Ala Phe Pro Gly His Val Ser Gln Ala Leu 
1               5                   10                  15      


Gly Thr Leu Leu Phe Leu Ala Ala Ser Leu Ser Ala Gln Asn Glu Gly 
            20                  25                  30          


Trp Asp Ser Pro Ile Cys Thr Glu Gly Val Val Ser Val Ser Trp Gly 
        35                  40                  45              


Glu Asn Thr Val Met Ser Cys Asn Ile Ser Asn Ala Phe Ser His Val 
    50                  55                  60                  


Asn Ile Lys Leu Arg Ala His Gly Gln Glu Ser Ala Ile Phe Asn Glu 
65                  70                  75                  80  


Val Ala Pro Gly Tyr 
                85  


<210>  355
<211>  170
<212>  PRT
<213>  Homo sapiens

<400>  355

Met Gln Thr Cys Pro Leu Ala Phe Pro Gly His Val Ser Gln Ala Leu 
1               5                   10                  15      


Gly Thr Leu Leu Phe Leu Ala Ala Ser Leu Ser Ala Gln Asn Glu Gly 
            20                  25                  30          


Trp Asp Ser Pro Ile Cys Thr Glu Gly Val Val Ser Val Ser Trp Gly 
        35                  40                  45              


Glu Asn Thr Val Met Ser Cys Asn Ile Ser Asn Ala Phe Ser His Val 
    50                  55                  60                  


Asn Ile Lys Leu Arg Ala His Gly Gln Glu Ser Ala Ile Phe Asn Glu 
65                  70                  75                  80  


Val Ala Pro Gly Tyr Phe Ser Arg Asp Gly Trp Gln Leu Gln Val Gln 
                85                  90                  95      


Gly Gly Val Ala Gln Leu Val Ile Lys Gly Ala Arg Asp Ser His Ala 
            100                 105                 110         


Gly Leu Tyr Met Trp His Leu Val Gly His Gln Arg Asn Asn Arg Gln 
        115                 120                 125             


Val Thr Leu Glu Val Ser Glu Pro Arg Gly Leu Lys Asp Arg Ala Ser 
    130                 135                 140                 


Ala Gln Leu Leu Gly Pro Gly Thr Ser Arg Gly Ala Glu Pro Gln Ser 
145                 150                 155                 160 


Ala Pro Asp Thr Gly Phe Trp Pro Val Pro 
                165                 170 


<210>  356
<211>  147
<212>  PRT
<213>  Homo sapiens

<400>  356

Met Gln Thr Cys Pro Leu Ala Phe Pro Gly His Val Ser Gln Ala Leu 
1               5                   10                  15      


Gly Thr Leu Leu Phe Leu Ala Ala Ser Leu Ser Ala Gln Asn Glu Gly 
            20                  25                  30          


Trp Asp Ser Pro Ile Cys Thr Glu Gly Val Val Ser Val Ser Trp Gly 
        35                  40                  45              


Glu Asn Thr Val Met Ser Cys Asn Ile Ser Asn Ala Phe Ser His Val 
    50                  55                  60                  


Asn Ile Lys Leu Arg Ala His Gly Gln Glu Ser Ala Ile Phe Asn Glu 
65                  70                  75                  80  


Val Ala Pro Gly Tyr Phe Ser Arg Asp Gly Trp Gln Leu Gln Val Gln 
                85                  90                  95      


Gly Gly Val Ala Gln Leu Val Ile Lys Gly Ala Arg Asp Ser His Ala 
            100                 105                 110         


Gly Leu Tyr Met Trp His Leu Val Gly His Gln Arg Asn Asn Arg Gln 
        115                 120                 125             


Val Thr Leu Glu Val Ser Glu Pro Arg Gly Leu Lys Asp Arg Ala Ser 
    130                 135                 140                 


Ala Gln Leu 
145         


<210>  357
<211>  165
<212>  PRT
<213>  Homo sapiens

<400>  357

Met Asp Ala Pro Arg Arg Asp Met Glu Leu Leu Ser Asn Ser Leu Ala 
1               5                   10                  15      


Ala Tyr Ala His Ile Arg Ala Asn Pro Glu Ser Phe Gly Leu Tyr Phe 
            20                  25                  30          


Val Leu Gly Val Cys Phe Gly Leu Leu Leu Thr Leu Cys Leu Leu Val 
        35                  40                  45              


Ile Ser Ile Ser Trp Ala Pro Arg Pro Arg Pro Arg Gly Pro Ala Gln 
    50                  55                  60                  


Arg Arg Asp Pro Arg Ser Ser Thr Leu Glu Pro Glu Asp Asp Asp Glu 
65                  70                  75                  80  


Asp Glu Glu Asp Thr Val Thr Arg Leu Gly Pro Asp Asp Thr Leu Pro 
                85                  90                  95      


Gly Pro Glu Leu Ser Ala Glu Pro Asp Gly Pro Leu Asn Val Asn Val 
            100                 105                 110         


Phe Thr Ser Ala Glu Glu Leu Glu Arg Ala Gln Arg Leu Glu Glu Arg 
        115                 120                 125             


Glu Arg Ile Leu Arg Glu Ile Trp Arg Thr Gly Gln Pro Asp Leu Leu 
    130                 135                 140                 


Gly Thr Gly Thr Leu Gly Pro Ser Pro Thr Ala Thr Gly Thr Leu Gly 
145                 150                 155                 160 


Arg Met His Tyr Tyr 
                165 


<210>  358
<211>  639
<212>  PRT
<213>  Homo sapiens

<400>  358

Met Asn Leu Glu Lys Leu Ser Lys Pro Glu Leu Leu Thr Leu Phe Ser 
1               5                   10                  15      


Ile Leu Glu Gly Glu Leu Glu Ala Arg Asp Leu Val Ile Glu Ala Leu 
            20                  25                  30          


Lys Ala Gln His Arg Asp Thr Phe Ile Glu Glu Arg Tyr Gly Lys Tyr 
        35                  40                  45              


Asn Ile Ser Asp Pro Leu Met Ala Leu Gln Arg Asp Phe Glu Thr Leu 
    50                  55                  60                  


Lys Glu Lys Asn Asp Gly Glu Lys Gln Pro Val Cys Thr Asn Pro Leu 
65                  70                  75                  80  


Ser Ile Leu Lys Val Val Met Lys Gln Cys Lys Asn Met Gln Glu Arg 
                85                  90                  95      


Met Leu Ser Gln Leu Ala Ala Ala Glu Ser Arg His Arg Lys Val Ile 
            100                 105                 110         


Leu Asp Leu Glu Glu Glu Arg Gln Arg His Ala Gln Asp Thr Ala Glu 
        115                 120                 125             


Gly Asp Asp Val Thr Tyr Met Leu Glu Lys Glu Arg Glu Arg Leu Thr 
    130                 135                 140                 


Gln Gln Leu Glu Phe Glu Lys Ser Gln Val Lys Lys Phe Glu Lys Glu 
145                 150                 155                 160 


Gln Lys Lys Leu Ser Ser Gln Leu Glu Glu Glu Arg Ser Arg His Lys 
                165                 170                 175     


Gln Leu Ser Ser Met Leu Val Leu Glu Cys Lys Lys Ala Thr Asn Lys 
            180                 185                 190         


Ala Ala Glu Glu Gly Gln Lys Ala Gly Glu Leu Ser Leu Lys Leu Glu 
        195                 200                 205             


Lys Glu Lys Ser Arg Val Ser Lys Leu Glu Glu Glu Leu Ala Ala Glu 
    210                 215                 220                 


Arg Lys Arg Gly Leu Gln Thr Glu Ala Gln Val Glu Lys Gln Leu Ser 
225                 230                 235                 240 


Glu Phe Asp Ile Glu Arg Glu Gln Leu Arg Ala Lys Leu Asn Arg Glu 
                245                 250                 255     


Glu Asn Arg Thr Lys Thr Leu Lys Glu Glu Met Glu Ser Leu Lys Lys 
            260                 265                 270         


Ile Val Lys Asp Leu Glu Ala Ser His Gln His Ser Ser Pro Asn Glu 
        275                 280                 285             


Gln Leu Lys Lys Pro Val Thr Val Ser Lys Gly Thr Ala Thr Glu Pro 
    290                 295                 300                 


Leu Met Leu Met Ser Val Phe Cys Gln Thr Glu Ser Phe Pro Ala Glu 
305                 310                 315                 320 


Arg Thr His Gly Ser Asn Ile Ala Lys Met Thr Asn Thr Gly Leu Pro 
                325                 330                 335     


Gly Pro Ala Thr Pro Ala Tyr Ser Tyr Ala Lys Thr Asn Gly His Cys 
            340                 345                 350         


Asp Pro Glu Ile Gln Thr Thr Arg Glu Leu Thr Ala Gly Asn Asn Val 
        355                 360                 365             


Glu Asn Gln Val Pro Pro Arg Glu Lys Ser Val Ala Leu Ala Gln Glu 
    370                 375                 380                 


Lys Pro Val Glu Asn Gly Gly Cys Pro Val Gly Ile Glu Thr Pro Val 
385                 390                 395                 400 


Pro Met Pro Ser Pro Leu Ser Ser Ser Gly Ser Ser Leu Ser Pro Ser 
                405                 410                 415     


Ser Thr Ala Ser Ser Ser Leu Thr Ser Ser Pro Cys Ser Ser Pro Val 
            420                 425                 430         


Leu Thr Lys Arg Leu Leu Gly Ser Ser Ala Ser Ser Pro Gly Tyr Gln 
        435                 440                 445             


Ser Ser Tyr Gln Val Gly Ile Asn Gln Arg Phe His Ala Ala Arg His 
    450                 455                 460                 


Lys Phe Gln Ser Gln Ala Asp Gln Asp Gln Gln Ala Ser Gly Leu Gln 
465                 470                 475                 480 


Ser Pro Pro Ser Arg Asp Leu Ser Pro Thr Leu Ile Asp Asn Ser Ala 
                485                 490                 495     


Ala Lys Gln Leu Ala Arg Asn Thr Val Thr Gln Val Leu Ser Arg Phe 
            500                 505                 510         


Thr Ser Gln Gln Gly Pro Ile Lys Pro Val Ser Pro Asn Ser Ser Pro 
        515                 520                 525             


Phe Gly Thr Asp Tyr Arg Asn Leu Ala Asn Thr Ala Asn Pro Arg Gly 
    530                 535                 540                 


Asp Thr Ser His Ser Pro Thr Pro Gly Lys Val Ser Ser Pro Leu Ser 
545                 550                 555                 560 


Pro Leu Ser Pro Gly Ile Lys Ser Pro Thr Ile Pro Arg Ala Glu Arg 
                565                 570                 575     


Gly Asn Pro Pro Pro Ile Pro Pro Lys Lys Pro Gly Leu Thr Pro Ser 
            580                 585                 590         


Pro Ser Ala Thr Thr Pro Leu Thr Lys Thr His Ser Gln Ala Ala Ser 
        595                 600                 605             


Leu Thr Thr Ala Glu Asp Leu Ala Ser Ser Cys Ser Ser Asn Thr Val 
    610                 615                 620                 


Val Ala Asn Gly Lys Asp Val Glu Leu Leu Leu Pro Thr Ser Ser 
625                 630                 635                 


<210>  359
<211>  271
<212>  PRT
<213>  Homo sapiens

<400>  359

Met Asn Leu Glu Lys Leu Ser Lys Pro Glu Leu Leu Thr Leu Phe Ser 
1               5                   10                  15      


Ile Leu Glu Gly Glu Leu Glu Ala Arg Asp Leu Val Ile Glu Ala Leu 
            20                  25                  30          


Lys Ala Gln His Arg Asp Thr Phe Ile Glu Glu Arg Tyr Gly Lys Tyr 
        35                  40                  45              


Asn Ile Ser Asp Pro Leu Met Ala Leu Gln Arg Asp Phe Glu Thr Leu 
    50                  55                  60                  


Lys Glu Lys Asn Asp Gly Glu Lys Gln Pro Val Cys Thr Asn Pro Leu 
65                  70                  75                  80  


Ser Ile Leu Lys Val Val Met Lys Gln Cys Lys Asn Met Gln Glu Arg 
                85                  90                  95      


Met Leu Ser Gln Leu Ala Ala Ala Glu Ser Arg His Arg Lys Val Ile 
            100                 105                 110         


Leu Asp Leu Glu Glu Glu Arg Gln Arg His Ala Gln Asp Thr Ala Glu 
        115                 120                 125             


Gly Asp Asp Val Thr Tyr Met Leu Glu Lys Glu Arg Glu Arg Leu Thr 
    130                 135                 140                 


Gln Gln Leu Glu Phe Glu Lys Ser Gln Val Lys Lys Phe Glu Lys Glu 
145                 150                 155                 160 


Gln Lys Lys Leu Ser Ser Gln Leu Glu Glu Glu Arg Ser Arg His Lys 
                165                 170                 175     


Gln Leu Ser Ser Met Leu Val Leu Glu Cys Lys Lys Ala Thr Asn Lys 
            180                 185                 190         


Ala Ala Glu Glu Gly Gln Lys Ala Gly Glu Leu Ser Leu Lys Leu Glu 
        195                 200                 205             


Lys Glu Lys Ser Arg Val Ser Lys Leu Glu Glu Glu Leu Ala Ala Glu 
    210                 215                 220                 


Arg Lys Arg Gly Leu Gln Thr Glu Ala Gln Val Glu Lys Gln Leu Ser 
225                 230                 235                 240 


Glu Phe Asp Ile Glu Arg Glu Gln Leu Arg Ala Lys Leu Asn Arg Glu 
                245                 250                 255     


Glu Asn Arg Thr Lys Thr Leu Lys Glu Glu Met Glu Ser Leu Lys 
            260                 265                 270     


<210>  360
<211>  396
<212>  PRT
<213>  Homo sapiens

<400>  360

Met Ser Ala Thr Asp Arg Met Gly Pro Arg Ala Val Pro Gly Leu Arg 
1               5                   10                  15      


Leu Ala Leu Leu Leu Leu Leu Val Leu Gly Thr Pro Lys Ser Gly Val 
            20                  25                  30          


Gln Gly Gln Glu Gly Leu Asp Phe Pro Glu Tyr Asp Gly Val Asp Arg 
        35                  40                  45              


Val Ile Asn Val Asn Ala Lys Asn Tyr Lys Asn Val Phe Lys Lys Tyr 
    50                  55                  60                  


Glu Val Leu Ala Leu Leu Tyr His Glu Pro Pro Glu Asp Asp Lys Ala 
65                  70                  75                  80  


Ser Gln Arg Gln Phe Glu Met Glu Glu Leu Ile Leu Glu Leu Ala Ala 
                85                  90                  95      


Gln Val Leu Glu Asp Lys Gly Val Gly Phe Gly Leu Val Asp Ser Glu 
            100                 105                 110         


Lys Asp Ala Ala Val Ala Lys Lys Leu Gly Leu Thr Glu Val Asp Ser 
        115                 120                 125             


Met Tyr Val Phe Lys Gly Asp Glu Val Ile Glu Tyr Asp Gly Glu Phe 
    130                 135                 140                 


Ser Ala Asp Thr Ile Val Glu Phe Leu Leu Asp Val Leu Glu Asp Pro 
145                 150                 155                 160 


Val Glu Leu Ile Glu Gly Glu Arg Glu Leu Gln Ala Phe Glu Asn Ile 
                165                 170                 175     


Glu Asp Glu Ile Lys Leu Ile Gly Tyr Phe Lys Ser Lys Asp Ser Glu 
            180                 185                 190         


His Tyr Lys Ala Phe Glu Asp Ala Ala Glu Glu Phe His Pro Tyr Ile 
        195                 200                 205             


Pro Phe Phe Ala Thr Phe Asp Ser Lys Val Ala Lys Lys Leu Thr Leu 
    210                 215                 220                 


Lys Leu Asn Glu Ile Asp Phe Tyr Glu Ala Phe Met Glu Glu Pro Val 
225                 230                 235                 240 


Thr Ile Pro Asp Lys Pro Asn Ser Glu Glu Glu Ile Val Asn Phe Val 
                245                 250                 255     


Glu Glu His Arg Arg Ser Thr Leu Arg Lys Leu Lys Pro Glu Ser Met 
            260                 265                 270         


Tyr Glu Thr Trp Glu Asp Asp Met Asp Gly Ile His Ile Val Ala Phe 
        275                 280                 285             


Ala Glu Glu Ala Asp Pro Asp Gly Phe Glu Phe Leu Glu Thr Leu Lys 
    290                 295                 300                 


Ala Val Ala Gln Asp Asn Thr Glu Asn Pro Asp Leu Ser Ile Ile Trp 
305                 310                 315                 320 


Ile Asp Pro Asp Asp Phe Pro Leu Leu Val Pro Tyr Trp Glu Lys Thr 
                325                 330                 335     


Phe Asp Ile Asp Leu Ser Ala Pro Gln Ile Gly Val Val Asn Val Thr 
            340                 345                 350         


Asp Ala Asp Ser Val Trp Met Glu Met Asp Asp Glu Glu Asp Leu Pro 
        355                 360                 365             


Ser Ala Glu Glu Leu Glu Asp Trp Leu Glu Asp Val Leu Glu Gly Glu 
    370                 375                 380                 


Ile Asn Thr Glu Asp Asp Asp Asp Asp Asp Asp Asp 
385                 390                 395     


<210>  361
<211>  188
<212>  PRT
<213>  Homo sapiens

<400>  361

Met Asp Val Asn Ile Ala Pro Leu Arg Ala Trp Asp Asp Phe Phe Pro 
1               5                   10                  15      


Gly Ser Asp Arg Phe Ala Arg Pro Asp Phe Arg Asp Ile Ser Lys Trp 
            20                  25                  30          


Asn Asn Arg Val Val Ser Asn Leu Leu Tyr Tyr Gln Thr Asn Tyr Leu 
        35                  40                  45              


Val Val Ala Ala Met Met Ile Ser Ile Val Gly Phe Leu Ser Pro Phe 
    50                  55                  60                  


Asn Met Ile Leu Gly Gly Ile Val Val Val Leu Val Phe Thr Gly Phe 
65                  70                  75                  80  


Val Trp Ala Ala His Asn Lys Asp Val Leu Arg Arg Met Lys Lys Arg 
                85                  90                  95      


Tyr Pro Thr Thr Phe Val Met Val Val Met Leu Ala Ser Tyr Phe Leu 
            100                 105                 110         


Ile Ser Met Phe Gly Gly Val Met Val Phe Val Phe Gly Ile Thr Phe 
        115                 120                 125             


Pro Leu Leu Leu Met Phe Ile His Ala Ser Leu Arg Leu Arg Asn Leu 
    130                 135                 140                 


Lys Asn Lys Leu Glu Asn Lys Met Glu Gly Ile Gly Leu Lys Arg Thr 
145                 150                 155                 160 


Pro Met Gly Ile Val Leu Asp Ala Leu Glu Gln Gln Glu Glu Gly Ile 
                165                 170                 175     


Asn Arg Leu Thr Asp Tyr Ile Ser Lys Val Lys Glu 
            180                 185             


<210>  362
<211>  88
<212>  PRT
<213>  Homo sapiens

<400>  362

Met Asp Val Asn Ile Ala Pro Leu Arg Ala Trp Asp Asp Phe Phe Pro 
1               5                   10                  15      


Gly Ser Asp Arg Phe Ala Arg Pro Asp Phe Arg Asp Ile Ser Lys Trp 
            20                  25                  30          


Asn Asn Arg Val Val Ser Asn Leu Leu Tyr Tyr Gln Thr Asn Tyr Leu 
        35                  40                  45              


Val Val Ala Ala Met Met Ile Ser Ile Val Gly Phe Leu Ser Pro Phe 
    50                  55                  60                  


Asn Pro Pro Ile Val Ser Glu Val Ser Arg Val Phe Met Lys Ser Asn 
65                  70                  75                  80  


Gly Lys Trp Ile Thr Arg Phe Leu 
                85              


<210>  363
<211>  93
<212>  PRT
<213>  Homo sapiens

<400>  363

Met Asp Val Asn Ile Ala Pro Leu Arg Ala Trp Asp Asp Phe Phe Pro 
1               5                   10                  15      


Gly Ser Asp Arg Phe Ala Arg Pro Asp Phe Arg Asp Ile Ser Lys Trp 
            20                  25                  30          


Asn Asn Arg Val Val Ser Asn Leu Leu Tyr Tyr Gln Thr Asn Tyr Leu 
        35                  40                  45              


Val Val Ala Ala Met Met Ile Ser Ile Val Gly Leu Glu Cys Asn Gly 
    50                  55                  60                  


Val Ile Ser Ala His Cys Asn Leu His Leu Leu Ser Ser Ser Asp Ser 
65                  70                  75                  80  


Pro Ala Ser Ala Ser Gln Val Ala Gly Ile Thr Gly Phe 
                85                  90              


<210>  364
<211>  59
<212>  PRT
<213>  Homo sapiens

<400>  364

Met Asp Val Asn Ile Ala Pro Leu Arg Ala Trp Asp Asp Phe Phe Pro 
1               5                   10                  15      


Gly Ser Asp Arg Phe Ala Arg Pro Asp Phe Arg Asp Ile Ser Lys Trp 
            20                  25                  30          


Asn Asn Arg Val Val Ser Asn Leu Leu Tyr Tyr Gln Thr Asn Tyr Leu 
        35                  40                  45              


Val Val Ala Ala Met Met Ile Ser Ile Val Gly 
    50                  55                  


<210>  365
<211>  357
<212>  PRT
<213>  Homo sapiens

<400>  365

Met Glu Lys Tyr Val Ala Ala Met Val Leu Ser Ala Ala Gly Asp Ala 
1               5                   10                  15      


Leu Gly Tyr Tyr Asn Gly Lys Trp Glu Phe Leu Gln Asp Gly Glu Lys 
            20                  25                  30          


Ile His Arg Gln Leu Ala Gln Leu Gly Gly Leu Asp Ala Leu Asp Val 
        35                  40                  45              


Gly Arg Trp Arg Val Ser Asp Asp Thr Val Met His Leu Ala Thr Ala 
    50                  55                  60                  


Glu Ala Leu Val Glu Ala Gly Lys Ala Pro Lys Leu Thr Gln Leu Tyr 
65                  70                  75                  80  


Tyr Leu Leu Ala Lys His Tyr Gln Asp Cys Met Glu Asp Met Asp Gly 
                85                  90                  95      


Arg Ala Pro Gly Gly Ala Ser Val His Asn Ala Met Gln Leu Lys Pro 
            100                 105                 110         


Gly Lys Pro Asn Gly Trp Arg Ile Pro Phe Asn Ser His Glu Gly Gly 
        115                 120                 125             


Cys Gly Ala Ala Met Arg Ala Met Cys Ile Gly Leu Arg Phe Pro His 
    130                 135                 140                 


His Ser Gln Leu Asp Thr Leu Ile Gln Val Ser Ile Glu Ser Gly Arg 
145                 150                 155                 160 


Met Thr His His His Pro Thr Gly Tyr Leu Gly Ala Leu Ala Ser Ala 
                165                 170                 175     


Leu Phe Thr Ala Tyr Ala Val Asn Ser Arg Pro Pro Leu Gln Trp Gly 
            180                 185                 190         


Lys Gly Leu Met Glu Leu Leu Pro Glu Ala Lys Lys Tyr Ile Val Gln 
        195                 200                 205             


Ser Gly Tyr Phe Val Glu Glu Asn Leu Gln His Trp Ser Tyr Phe Gln 
    210                 215                 220                 


Thr Lys Trp Glu Asn Tyr Leu Lys Leu Arg Gly Ile Leu Asp Gly Glu 
225                 230                 235                 240 


Ser Ala Pro Thr Phe Pro Glu Ser Phe Gly Val Lys Glu Arg Asp Gln 
                245                 250                 255     


Phe Tyr Thr Ser Leu Ser Tyr Ser Gly Trp Gly Gly Ser Ser Gly His 
            260                 265                 270         


Asp Ala Pro Met Ile Ala Tyr Asp Ala Val Leu Ala Ala Gly Asp Ser 
        275                 280                 285             


Trp Lys Glu Leu Ala His Arg Ala Phe Phe His Gly Gly Asp Ser Asp 
    290                 295                 300                 


Ser Thr Ala Ala Ile Ala Gly Cys Trp Trp Gly Val Met Tyr Gly Phe 
305                 310                 315                 320 


Lys Gly Val Ser Pro Ser Asn Tyr Glu Lys Leu Glu Tyr Arg Asn Arg 
                325                 330                 335     


Leu Glu Glu Thr Ala Arg Ala Leu Tyr Ser Leu Gly Ser Lys Glu Asp 
            340                 345                 350         


Thr Val Ile Ser Leu 
        355         


<210>  366
<211>  357
<212>  PRT
<213>  Homo sapiens

<400>  366

Met Glu Lys Tyr Val Ala Ala Met Val Leu Ser Ala Ala Gly Asp Ala 
1               5                   10                  15      


Leu Gly Tyr Tyr Asn Gly Lys Trp Glu Phe Leu Gln Asp Gly Glu Lys 
            20                  25                  30          


Ile His Arg Gln Leu Ala Gln Leu Gly Gly Leu Asp Ala Leu Asp Val 
        35                  40                  45              


Gly Arg Trp Arg Val Ser Asp Asp Thr Val Met His Leu Ala Thr Ala 
    50                  55                  60                  


Glu Ala Leu Val Glu Ala Gly Lys Ala Pro Lys Leu Thr Gln Leu Tyr 
65                  70                  75                  80  


Tyr Leu Leu Ala Lys His Tyr Gln Asp Cys Met Glu Asp Met Asp Gly 
                85                  90                  95      


Arg Ala Pro Gly Gly Ala Ser Val His Asn Ala Met Gln Leu Lys Pro 
            100                 105                 110         


Gly Lys Pro Asn Gly Trp Arg Ile Pro Phe Asn Ser His Glu Gly Gly 
        115                 120                 125             


Cys Gly Ala Ala Met Arg Ala Met Cys Ile Gly Leu Arg Phe Pro His 
    130                 135                 140                 


His Ser Gln Leu Asp Thr Leu Ile Gln Val Ser Ile Glu Ser Gly Arg 
145                 150                 155                 160 


Met Thr His His His Pro Thr Gly Tyr Leu Gly Ala Leu Ala Ser Ala 
                165                 170                 175     


Leu Phe Thr Ala Tyr Ala Val Asn Ser Arg Pro Pro Leu Gln Trp Gly 
            180                 185                 190         


Lys Gly Leu Met Glu Leu Leu Pro Glu Ala Lys Lys Tyr Ile Val Gln 
        195                 200                 205             


Ser Gly Tyr Phe Val Glu Glu Asn Leu Gln His Trp Ser Tyr Phe Gln 
    210                 215                 220                 


Thr Lys Trp Glu Asn Tyr Leu Lys Leu Arg Gly Ile Leu Asp Gly Glu 
225                 230                 235                 240 


Ser Ala Pro Thr Phe Pro Glu Ser Phe Gly Val Lys Glu Arg Asp Gln 
                245                 250                 255     


Phe Tyr Thr Ser Leu Ser Tyr Ser Gly Trp Gly Gly Ser Ser Gly His 
            260                 265                 270         


Asp Ala Pro Met Ile Ala Tyr Asp Ala Val Leu Ala Ala Gly Asp Ser 
        275                 280                 285             


Trp Lys Glu Leu Ala His Arg Ala Phe Phe His Gly Gly Asp Ser Asp 
    290                 295                 300                 


Ser Thr Ala Ala Ile Ala Gly Cys Trp Trp Gly Val Met Tyr Gly Phe 
305                 310                 315                 320 


Lys Gly Val Ser Pro Ser Asn Tyr Glu Lys Leu Glu Tyr Arg Asn Arg 
                325                 330                 335     


Leu Glu Glu Thr Ala Arg Ala Leu Tyr Ser Leu Gly Ser Lys Glu Asp 
            340                 345                 350         


Thr Val Ile Ser Leu 
        355         


<210>  367
<211>  357
<212>  PRT
<213>  Homo sapiens

<400>  367

Met Glu Lys Tyr Val Ala Ala Met Val Leu Ser Ala Ala Gly Asp Ala 
1               5                   10                  15      


Leu Gly Tyr Tyr Asn Gly Lys Trp Glu Phe Leu Gln Asp Gly Glu Lys 
            20                  25                  30          


Ile His Arg Gln Leu Ala Gln Leu Gly Gly Leu Asp Ala Leu Asp Val 
        35                  40                  45              


Gly Arg Trp Arg Val Ser Asp Asp Thr Val Met His Leu Ala Thr Ala 
    50                  55                  60                  


Glu Ala Leu Val Glu Ala Gly Lys Ala Pro Lys Leu Thr Gln Leu Tyr 
65                  70                  75                  80  


Tyr Leu Leu Ala Lys His Tyr Gln Asp Cys Met Glu Asp Met Asp Gly 
                85                  90                  95      


Arg Ala Pro Gly Gly Ala Ser Val His Asn Ala Met Gln Leu Lys Pro 
            100                 105                 110         


Gly Lys Pro Asn Gly Trp Arg Ile Pro Phe Asn Ser His Glu Gly Gly 
        115                 120                 125             


Cys Gly Ala Ala Met Arg Ala Met Cys Ile Gly Leu Arg Phe Pro His 
    130                 135                 140                 


His Ser Gln Leu Asp Thr Leu Ile Gln Val Ser Ile Glu Ser Gly Arg 
145                 150                 155                 160 


Met Thr His His His Pro Thr Gly Tyr Leu Gly Ala Leu Ala Ser Ala 
                165                 170                 175     


Leu Phe Thr Ala Tyr Ala Val Asn Ser Arg Pro Pro Leu Gln Trp Gly 
            180                 185                 190         


Lys Gly Leu Met Glu Leu Leu Pro Glu Ala Lys Lys Tyr Ile Val Gln 
        195                 200                 205             


Ser Gly Tyr Phe Val Glu Glu Asn Leu Gln His Trp Ser Tyr Phe Gln 
    210                 215                 220                 


Thr Lys Trp Glu Asn Tyr Leu Lys Leu Arg Gly Ile Leu Asp Gly Glu 
225                 230                 235                 240 


Ser Ala Pro Thr Phe Pro Glu Ser Phe Gly Val Lys Glu Arg Asp Gln 
                245                 250                 255     


Phe Tyr Thr Ser Leu Ser Tyr Ser Gly Trp Gly Gly Ser Ser Gly His 
            260                 265                 270         


Asp Ala Pro Met Ile Ala Tyr Asp Ala Val Leu Ala Ala Gly Asp Ser 
        275                 280                 285             


Trp Lys Glu Leu Ala His Arg Ala Phe Phe His Gly Gly Asp Ser Asp 
    290                 295                 300                 


Ser Thr Ala Ala Ile Ala Gly Cys Trp Trp Gly Val Met Tyr Gly Phe 
305                 310                 315                 320 


Lys Gly Val Ser Pro Ser Asn Tyr Glu Lys Leu Glu Tyr Arg Asn Arg 
                325                 330                 335     


Leu Glu Glu Thr Ala Arg Ala Leu Tyr Ser Leu Gly Ser Lys Glu Asp 
            340                 345                 350         


Thr Val Ile Ser Leu 
        355         


<210>  368
<211>  357
<212>  PRT
<213>  Homo sapiens

<400>  368

Met Glu Lys Tyr Val Ala Ala Met Val Leu Ser Ala Ala Gly Asp Ala 
1               5                   10                  15      


Leu Gly Tyr Tyr Asn Gly Lys Trp Glu Phe Leu Gln Asp Gly Glu Lys 
            20                  25                  30          


Ile His Arg Gln Leu Ala Gln Leu Gly Gly Leu Asp Ala Leu Asp Val 
        35                  40                  45              


Gly Arg Trp Arg Val Ser Asp Asp Thr Val Met His Leu Ala Thr Ala 
    50                  55                  60                  


Glu Ala Leu Val Glu Ala Gly Lys Ala Pro Lys Leu Thr Gln Leu Tyr 
65                  70                  75                  80  


Tyr Leu Leu Ala Lys His Tyr Gln Asp Cys Met Glu Asp Met Asp Gly 
                85                  90                  95      


Arg Ala Pro Gly Gly Ala Ser Val His Asn Ala Met Gln Leu Lys Pro 
            100                 105                 110         


Gly Lys Pro Asn Gly Trp Arg Ile Pro Phe Asn Ser His Glu Gly Gly 
        115                 120                 125             


Cys Gly Ala Ala Met Arg Ala Met Cys Ile Gly Leu Arg Phe Pro His 
    130                 135                 140                 


His Ser Gln Leu Asp Thr Leu Ile Gln Val Ser Ile Glu Ser Gly Arg 
145                 150                 155                 160 


Met Thr His His His Pro Thr Gly Tyr Leu Gly Ala Leu Ala Ser Ala 
                165                 170                 175     


Leu Phe Thr Ala Tyr Ala Val Asn Ser Arg Pro Pro Leu Gln Trp Gly 
            180                 185                 190         


Lys Gly Leu Met Glu Leu Leu Pro Glu Ala Lys Lys Tyr Ile Val Gln 
        195                 200                 205             


Ser Gly Tyr Phe Val Glu Glu Asn Leu Gln His Trp Ser Tyr Phe Gln 
    210                 215                 220                 


Thr Lys Trp Glu Asn Tyr Leu Lys Leu Arg Gly Ile Leu Asp Gly Glu 
225                 230                 235                 240 


Ser Ala Pro Thr Phe Pro Glu Ser Phe Gly Val Lys Glu Arg Asp Gln 
                245                 250                 255     


Phe Tyr Thr Ser Leu Ser Tyr Ser Gly Trp Gly Gly Ser Ser Gly His 
            260                 265                 270         


Asp Ala Pro Met Ile Ala Tyr Asp Ala Val Leu Ala Ala Gly Asp Ser 
        275                 280                 285             


Trp Lys Glu Leu Ala His Arg Ala Phe Phe His Gly Gly Asp Ser Asp 
    290                 295                 300                 


Ser Thr Ala Ala Ile Ala Gly Cys Trp Trp Gly Val Met Tyr Gly Phe 
305                 310                 315                 320 


Lys Gly Val Ser Pro Ser Asn Tyr Glu Lys Leu Glu Tyr Arg Asn Arg 
                325                 330                 335     


Leu Glu Glu Thr Ala Arg Ala Leu Tyr Ser Leu Gly Ser Lys Glu Asp 
            340                 345                 350         


Thr Val Ile Ser Leu 
        355         


<210>  369
<211>  125
<212>  PRT
<213>  Homo sapiens

<400>  369

Met Glu Lys Tyr Val Ala Ala Met Val Leu Ser Ala Ala Gly Asp Ala 
1               5                   10                  15      


Leu Gly Tyr Tyr Asn Gly Lys Trp Glu Phe Leu Gln Asp Gly Glu Lys 
            20                  25                  30          


Ile His Arg Gln Leu Ala Gln Leu Gly Gly Leu Asp Ala Leu Asp Val 
        35                  40                  45              


Gly Arg Trp Arg Val Ser Asp Asp Thr Val Met His Leu Ala Thr Ala 
    50                  55                  60                  


Glu Ala Leu Val Glu Ala Gly Lys Ala Pro Lys Leu Thr Gln Leu Tyr 
65                  70                  75                  80  


Tyr Leu Leu Ala Lys His Tyr Gln Asp Cys Met Glu Asp Met Asp Gly 
                85                  90                  95      


Arg Ala Pro Gly Gly Ala Ser Val His Asn Ala Met Gln Leu Lys Pro 
            100                 105                 110         


Gly Lys Pro Asn Gly Trp Arg Ile Pro Phe Asn Ser His 
        115                 120                 125 


<210>  370
<211>  974
<212>  PRT
<213>  Homo sapiens

<400>  370

Met Ala Gly Arg Val Pro Ser Leu Leu Val Leu Leu Val Phe Pro Ser 
1               5                   10                  15      


Ser Cys Leu Ala Phe Arg Ser Pro Leu Ser Val Phe Lys Arg Phe Lys 
            20                  25                  30          


Glu Thr Thr Arg Pro Phe Ser Asn Glu Cys Leu Gly Thr Thr Arg Pro 
        35                  40                  45              


Val Val Pro Ile Asp Ser Ser Asp Phe Ala Leu Asp Ile Arg Met Pro 
    50                  55                  60                  


Gly Val Thr Pro Lys Gln Ser Asp Thr Tyr Phe Cys Met Ser Met Arg 
65                  70                  75                  80  


Ile Pro Val Asp Glu Glu Ala Phe Val Ile Asp Phe Lys Pro Arg Ala 
                85                  90                  95      


Ser Met Asp Thr Val His His Met Leu Leu Phe Gly Cys Asn Met Pro 
            100                 105                 110         


Ser Ser Thr Gly Ser Tyr Trp Phe Cys Asp Glu Gly Thr Cys Thr Asp 
        115                 120                 125             


Lys Ala Asn Ile Leu Tyr Ala Trp Ala Arg Asn Ala Pro Pro Thr Arg 
    130                 135                 140                 


Leu Pro Lys Gly Val Gly Phe Arg Val Gly Gly Glu Thr Gly Ser Lys 
145                 150                 155                 160 


Tyr Phe Val Leu Gln Val His Tyr Gly Asp Ile Ser Ala Phe Arg Asp 
                165                 170                 175     


Asn Asn Lys Asp Cys Ser Gly Val Ser Leu His Leu Thr Arg Leu Pro 
            180                 185                 190         


Gln Pro Leu Ile Ala Gly Met Tyr Leu Met Met Ser Val Asp Thr Val 
        195                 200                 205             


Ile Pro Ala Gly Glu Lys Val Val Asn Ser Asp Ile Ser Cys His Tyr 
    210                 215                 220                 


Lys Asn Tyr Pro Met His Val Phe Ala Tyr Arg Val His Thr His His 
225                 230                 235                 240 


Leu Gly Lys Val Val Ser Gly Tyr Arg Val Arg Asn Gly Gln Trp Thr 
                245                 250                 255     


Leu Ile Gly Arg Gln Ser Pro Gln Leu Pro Gln Ala Phe Tyr Pro Val 
            260                 265                 270         


Gly His Pro Val Asp Val Ser Phe Gly Asp Leu Leu Ala Ala Arg Cys 
        275                 280                 285             


Val Phe Thr Gly Glu Gly Arg Thr Glu Ala Thr His Ile Gly Gly Thr 
    290                 295                 300                 


Ser Ser Asp Glu Met Cys Asn Leu Tyr Ile Met Tyr Tyr Met Glu Ala 
305                 310                 315                 320 


Lys His Ala Val Ser Phe Met Thr Cys Thr Gln Asn Val Ala Pro Asp 
                325                 330                 335     


Met Phe Arg Thr Ile Pro Pro Glu Ala Asn Ile Pro Ile Pro Val Lys 
            340                 345                 350         


Ser Asp Met Val Met Met His Glu His His Lys Glu Thr Glu Tyr Lys 
        355                 360                 365             


Asp Lys Ile Pro Leu Leu Gln Gln Pro Lys Arg Glu Glu Glu Glu Val 
    370                 375                 380                 


Leu Asp Gln Gly Asp Phe Tyr Ser Leu Leu Ser Lys Leu Leu Gly Glu 
385                 390                 395                 400 


Arg Glu Asp Val Val His Val His Lys Tyr Asn Pro Thr Glu Lys Ala 
                405                 410                 415     


Glu Ser Glu Ser Asp Leu Val Ala Glu Ile Ala Asn Val Val Gln Lys 
            420                 425                 430         


Lys Asp Leu Gly Arg Ser Asp Ala Arg Glu Gly Ala Glu His Glu Arg 
        435                 440                 445             


Gly Asn Ala Ile Leu Val Arg Asp Arg Ile His Lys Phe His Arg Leu 
    450                 455                 460                 


Val Ser Thr Leu Arg Pro Pro Glu Ser Arg Val Phe Ser Leu Gln Gln 
465                 470                 475                 480 


Pro Pro Pro Gly Glu Gly Thr Trp Glu Pro Glu His Thr Gly Asp Phe 
                485                 490                 495     


His Met Glu Glu Ala Leu Asp Trp Pro Gly Val Tyr Leu Leu Pro Gly 
            500                 505                 510         


Gln Val Ser Gly Val Ala Leu Asp Pro Lys Asn Asn Leu Val Ile Phe 
        515                 520                 525             


His Arg Gly Asp His Val Trp Asp Gly Asn Ser Phe Asp Ser Lys Phe 
    530                 535                 540                 


Val Tyr Gln Gln Ile Gly Leu Gly Pro Ile Glu Glu Asp Thr Ile Leu 
545                 550                 555                 560 


Val Ile Asp Pro Asn Asn Ala Ala Val Leu Gln Ser Ser Gly Lys Asn 
                565                 570                 575     


Leu Phe Tyr Leu Pro His Gly Leu Ser Ile Asp Lys Asp Gly Asn Tyr 
            580                 585                 590         


Trp Val Thr Asp Val Ala Leu His Gln Val Phe Lys Leu Asp Pro Asn 
        595                 600                 605             


Asn Lys Glu Gly Pro Val Leu Ile Leu Gly Arg Ser Met Gln Pro Gly 
    610                 615                 620                 


Ser Asp Gln Asn His Phe Cys Gln Pro Thr Asp Val Ala Val Asp Pro 
625                 630                 635                 640 


Gly Thr Gly Ala Ile Tyr Val Ser Asp Gly Tyr Cys Asn Ser Arg Ile 
                645                 650                 655     


Val Gln Phe Ser Pro Ser Gly Lys Phe Ile Thr Gln Trp Gly Glu Glu 
            660                 665                 670         


Ser Ser Gly Ser Ser Pro Leu Pro Gly Gln Phe Thr Val Pro His Ser 
        675                 680                 685             


Leu Ala Leu Val Pro Leu Leu Gly Gln Leu Cys Val Ala Asp Arg Glu 
    690                 695                 700                 


Asn Gly Arg Ile Gln Cys Phe Lys Thr Asp Thr Lys Glu Phe Val Arg 
705                 710                 715                 720 


Glu Ile Lys His Ser Ser Phe Gly Arg Asn Val Phe Ala Ile Ser Tyr 
                725                 730                 735     


Ile Pro Gly Leu Leu Phe Ala Val Asn Gly Lys Pro His Phe Gly Asp 
            740                 745                 750         


Gln Glu Pro Val Gln Gly Phe Val Met Asn Phe Ser Asn Gly Glu Ile 
        755                 760                 765             


Ile Asp Ile Phe Lys Pro Val Arg Lys His Phe Asp Met Pro His Asp 
    770                 775                 780                 


Ile Val Ala Ser Glu Asp Gly Thr Val Tyr Ile Gly Asp Ala His Thr 
785                 790                 795                 800 


Asn Thr Val Trp Lys Phe Thr Leu Thr Glu Lys Leu Glu His Arg Ser 
                805                 810                 815     


Val Lys Lys Ala Gly Ile Glu Val Gln Glu Ile Lys Glu Ala Glu Ala 
            820                 825                 830         


Val Val Glu Thr Lys Met Glu Asn Lys Pro Thr Ser Ser Glu Leu Gln 
        835                 840                 845             


Lys Met Gln Glu Lys Gln Lys Leu Ile Lys Glu Pro Gly Ser Gly Val 
    850                 855                 860                 


Pro Val Val Leu Ile Thr Thr Leu Leu Val Ile Pro Val Val Val Leu 
865                 870                 875                 880 


Leu Ala Ile Ala Ile Phe Ile Arg Trp Lys Lys Ser Arg Ala Phe Gly 
                885                 890                 895     


Ala Asp Ser Glu His Lys Leu Glu Thr Ser Ser Gly Arg Val Leu Gly 
            900                 905                 910         


Arg Phe Arg Gly Lys Gly Ser Gly Gly Leu Asn Leu Gly Asn Phe Phe 
        915                 920                 925             


Ala Ser Arg Lys Gly Tyr Ser Arg Lys Gly Phe Asp Arg Leu Ser Thr 
    930                 935                 940                 


Glu Gly Ser Asp Gln Glu Lys Glu Asp Asp Gly Ser Glu Ser Glu Glu 
945                 950                 955                 960 


Glu Tyr Ser Ala Pro Leu Pro Ala Leu Ala Pro Ser Ser Ser 
                965                 970                 


<210>  371
<211>  175
<212>  PRT
<213>  Homo sapiens

<400>  371

Met Ala Gly Arg Val Pro Ser Leu Leu Val Leu Leu Val Phe Pro Ser 
1               5                   10                  15      


Ser Cys Leu Ala Phe Arg Ser Pro Leu Ser Val Phe Lys Arg Phe Lys 
            20                  25                  30          


Glu Thr Thr Arg Pro Phe Ser Asn Glu Cys Leu Gly Thr Thr Arg Pro 
        35                  40                  45              


Val Val Pro Ile Asp Ser Ser Asp Phe Ala Leu Asp Ile Arg Met Pro 
    50                  55                  60                  


Gly Val Thr Pro Lys Gln Leu Thr Ser Ser Leu Glu Pro Ala Trp Ile 
65                  70                  75                  80  


Leu Ser Ile Thr Cys Tyr Phe Leu Asp Ala Ile Cys Leu His Pro Leu 
                85                  90                  95      


Glu Val Thr Gly Phe Val Met Lys Glu Pro Val Gln Ile Lys Pro Ile 
            100                 105                 110         


Phe Cys Met Pro Gly Arg Glu Met Leu Pro Leu Pro Gly Ser Pro Lys 
        115                 120                 125             


Val Leu Asp Ser Glu Leu Glu Glu Arg Leu Glu Val Asn Thr Leu Tyr 
    130                 135                 140                 


Tyr Arg Tyr Thr Met Gly Ile Leu Val Leu Leu Glu Ile Ile Thr Arg 
145                 150                 155                 160 


Thr Val Leu Val Cys Pro Tyr Thr Ser His Val Cys His Ser Leu 
                165                 170                 175 


<210>  372
<211>  887
<212>  PRT
<213>  Homo sapiens

<400>  372

Met Ala Gly Arg Val Pro Ser Leu Leu Val Leu Leu Val Phe Pro Ser 
1               5                   10                  15      


Ser Cys Leu Ala Phe Arg Ser Pro Leu Ser Val Phe Lys Arg Phe Lys 
            20                  25                  30          


Glu Thr Thr Arg Pro Phe Ser Asn Glu Cys Leu Gly Thr Thr Arg Pro 
        35                  40                  45              


Val Val Pro Ile Asp Ser Ser Asp Phe Ala Leu Asp Ile Arg Met Pro 
    50                  55                  60                  


Gly Val Thr Pro Lys Gln Ser Asp Thr Tyr Phe Cys Met Ser Met Arg 
65                  70                  75                  80  


Ile Pro Val Asp Glu Glu Ala Phe Val Ile Asp Phe Lys Pro Arg Ala 
                85                  90                  95      


Ser Met Asp Thr Val His His Met Leu Leu Phe Gly Cys Asn Met Pro 
            100                 105                 110         


Ser Ser Thr Gly Ser Tyr Trp Phe Cys Asp Glu Gly Thr Cys Thr Asp 
        115                 120                 125             


Lys Ala Asn Ile Leu Tyr Ala Trp Ala Arg Asn Ala Pro Pro Thr Arg 
    130                 135                 140                 


Leu Pro Lys Gly Val Gly Phe Arg Val Gly Gly Glu Thr Gly Ser Lys 
145                 150                 155                 160 


Tyr Phe Val Leu Gln Val His Tyr Gly Asp Ile Ser Ala Phe Arg Asp 
                165                 170                 175     


Asn Asn Lys Asp Cys Ser Gly Val Ser Leu His Leu Thr Arg Leu Pro 
            180                 185                 190         


Gln Pro Leu Ile Ala Gly Met Tyr Leu Met Met Ser Val Asp Thr Val 
        195                 200                 205             


Ile Pro Ala Gly Glu Lys Val Val Asn Ser Asp Ile Ser Cys His Tyr 
    210                 215                 220                 


Lys Asn Tyr Pro Met His Val Phe Ala Tyr Arg Val His Thr His His 
225                 230                 235                 240 


Leu Gly Lys Val Val Ser Gly Tyr Arg Val Arg Asn Gly Gln Trp Thr 
                245                 250                 255     


Leu Ile Gly Arg Gln Ser Pro Gln Leu Pro Gln Ala Phe Tyr Pro Val 
            260                 265                 270         


Gly His Pro Val Asp Val Ser Phe Gly Asp Leu Leu Ala Ala Arg Cys 
        275                 280                 285             


Val Phe Thr Gly Glu Gly Arg Thr Glu Ala Thr His Ile Gly Gly Thr 
    290                 295                 300                 


Ser Ser Asp Glu Met Cys Asn Leu Tyr Ile Met Tyr Tyr Met Glu Ala 
305                 310                 315                 320 


Lys His Ala Val Ser Phe Met Thr Cys Thr Gln Asn Val Ala Pro Asp 
                325                 330                 335     


Met Phe Arg Thr Ile Pro Pro Glu Ala Asn Ile Pro Ile Pro Val Lys 
            340                 345                 350         


Ser Asp Met Val Met Met His Glu His His Lys Glu Thr Glu Tyr Lys 
        355                 360                 365             


Asp Lys Ile Pro Leu Leu Gln Gln Pro Lys Arg Glu Glu Glu Glu Val 
    370                 375                 380                 


Leu Asp Gln Gly Asp Phe Tyr Ser Leu Leu Ser Lys Leu Leu Gly Glu 
385                 390                 395                 400 


Arg Glu Asp Val Val His Val His Lys Tyr Asn Pro Thr Glu Lys Ala 
                405                 410                 415     


Glu Ser Glu Ser Asp Leu Val Ala Glu Ile Ala Asn Val Val Gln Lys 
            420                 425                 430         


Lys Asp Leu Gly Arg Ser Asp Ala Arg Glu Gly Ala Glu His Glu Arg 
        435                 440                 445             


Gly Asn Ala Ile Leu Val Arg Asp Arg Ile His Lys Phe His Arg Leu 
    450                 455                 460                 


Val Ser Thr Leu Arg Pro Pro Glu Ser Arg Val Phe Ser Leu Gln Gln 
465                 470                 475                 480 


Pro Pro Pro Gly Glu Gly Thr Trp Glu Pro Glu His Thr Gly Asp Phe 
                485                 490                 495     


His Met Glu Glu Ala Leu Asp Trp Pro Gly Val Tyr Leu Leu Pro Gly 
            500                 505                 510         


Gln Val Ser Gly Val Ala Leu Asp Pro Lys Asn Asn Leu Val Ile Phe 
        515                 520                 525             


His Arg Gly Asp His Val Trp Asp Gly Asn Ser Phe Asp Ser Lys Phe 
    530                 535                 540                 


Val Tyr Gln Gln Ile Gly Leu Gly Pro Ile Glu Glu Asp Thr Ile Leu 
545                 550                 555                 560 


Val Ile Asp Pro Asn Asn Ala Ala Val Leu Gln Ser Ser Gly Lys Asn 
                565                 570                 575     


Leu Phe Tyr Leu Pro His Gly Leu Ser Ile Asp Lys Asp Gly Asn Tyr 
            580                 585                 590         


Trp Val Thr Asp Val Ala Leu His Gln Val Phe Lys Leu Asp Pro Asn 
        595                 600                 605             


Asn Lys Glu Gly Pro Val Leu Ile Leu Gly Arg Ser Met Gln Pro Gly 
    610                 615                 620                 


Ser Asp Gln Asn His Phe Cys Gln Pro Thr Asp Val Ala Val Asp Pro 
625                 630                 635                 640 


Gly Thr Gly Ala Ile Tyr Val Ser Asp Gly Tyr Cys Asn Ser Arg Ile 
                645                 650                 655     


Val Gln Phe Ser Pro Ser Gly Lys Phe Ile Thr Gln Trp Gly Glu Glu 
            660                 665                 670         


Ser Ser Gly Ser Ser Pro Leu Pro Gly Gln Phe Thr Val Pro His Ser 
        675                 680                 685             


Leu Ala Leu Val Pro Leu Leu Gly Gln Leu Cys Val Ala Asp Arg Glu 
    690                 695                 700                 


Asn Gly Arg Ile Gln Cys Phe Lys Thr Asp Thr Lys Glu Phe Val Arg 
705                 710                 715                 720 


Glu Ile Lys His Ser Ser Phe Gly Arg Asn Val Phe Ala Ile Ser Tyr 
                725                 730                 735     


Ile Pro Gly Leu Leu Phe Ala Val Asn Gly Lys Pro His Phe Gly Asp 
            740                 745                 750         


Gln Glu Pro Val Gln Gly Phe Val Met Asn Phe Ser Asn Gly Glu Ile 
        755                 760                 765             


Ile Asp Ile Phe Lys Pro Val Arg Lys His Phe Asp Met Pro His Asp 
    770                 775                 780                 


Ile Val Ala Ser Glu Asp Gly Thr Val Tyr Ile Gly Asp Ala His Thr 
785                 790                 795                 800 


Asn Thr Val Trp Lys Phe Thr Leu Thr Glu Lys Leu Glu His Arg Ser 
                805                 810                 815     


Val Lys Lys Ala Gly Ile Glu Val Gln Glu Ile Lys Gly Lys Gly Ser 
            820                 825                 830         


Gly Gly Leu Asn Leu Gly Asn Phe Phe Ala Ser Arg Lys Gly Tyr Ser 
        835                 840                 845             


Arg Lys Gly Phe Asp Arg Leu Ser Thr Glu Gly Ser Asp Gln Glu Lys 
    850                 855                 860                 


Glu Asp Asp Gly Ser Glu Ser Glu Glu Glu Tyr Ser Ala Pro Leu Pro 
865                 870                 875                 880 


Ala Leu Ala Pro Ser Ser Ser 
                885         


<210>  373
<211>  866
<212>  PRT
<213>  Homo sapiens

<400>  373

Met Ala Gly Arg Val Pro Ser Leu Leu Val Leu Leu Val Phe Pro Ser 
1               5                   10                  15      


Ser Cys Leu Ala Phe Arg Ser Pro Leu Ser Val Phe Lys Arg Phe Lys 
            20                  25                  30          


Glu Thr Thr Arg Pro Phe Ser Asn Glu Cys Leu Gly Thr Thr Arg Pro 
        35                  40                  45              


Val Val Pro Ile Asp Ser Ser Asp Phe Ala Leu Asp Ile Arg Met Pro 
    50                  55                  60                  


Gly Val Thr Pro Lys Gln Ser Asp Thr Tyr Phe Cys Met Ser Met Arg 
65                  70                  75                  80  


Ile Pro Val Asp Glu Glu Ala Phe Val Ile Asp Phe Lys Pro Arg Ala 
                85                  90                  95      


Ser Met Asp Thr Val His His Met Leu Leu Phe Gly Cys Asn Met Pro 
            100                 105                 110         


Ser Ser Thr Gly Ser Tyr Trp Phe Cys Asp Glu Gly Thr Cys Thr Asp 
        115                 120                 125             


Lys Ala Asn Ile Leu Tyr Ala Trp Ala Arg Asn Ala Pro Pro Thr Arg 
    130                 135                 140                 


Leu Pro Lys Gly Val Gly Phe Arg Val Gly Gly Glu Thr Gly Ser Lys 
145                 150                 155                 160 


Tyr Phe Val Leu Gln Val His Tyr Gly Asp Ile Ser Ala Phe Arg Asp 
                165                 170                 175     


Asn Asn Lys Asp Cys Ser Gly Val Ser Leu His Leu Thr Arg Leu Pro 
            180                 185                 190         


Gln Pro Leu Ile Ala Gly Met Tyr Leu Met Met Ser Val Asp Thr Val 
        195                 200                 205             


Ile Pro Ala Gly Glu Lys Val Val Asn Ser Asp Ile Ser Cys His Tyr 
    210                 215                 220                 


Lys Asn Tyr Pro Met His Val Phe Ala Tyr Arg Val His Thr His His 
225                 230                 235                 240 


Leu Gly Lys Val Val Ser Gly Tyr Arg Val Arg Asn Gly Gln Trp Thr 
                245                 250                 255     


Leu Ile Gly Arg Gln Ser Pro Gln Leu Pro Gln Ala Phe Tyr Pro Val 
            260                 265                 270         


Gly His Pro Val Asp Val Ser Phe Gly Asp Leu Leu Ala Ala Arg Cys 
        275                 280                 285             


Val Phe Thr Gly Glu Gly Arg Thr Glu Ala Thr His Ile Gly Gly Thr 
    290                 295                 300                 


Ser Ser Asp Glu Met Cys Asn Leu Tyr Ile Met Tyr Tyr Met Glu Ala 
305                 310                 315                 320 


Lys His Ala Val Ser Phe Met Thr Cys Thr Gln Asn Val Ala Pro Asp 
                325                 330                 335     


Met Phe Arg Thr Ile Pro Pro Glu Ala Asn Ile Pro Ile Pro Val Lys 
            340                 345                 350         


Ser Asp Met Val Met Met His Glu His His Lys Glu Thr Glu Tyr Lys 
        355                 360                 365             


Asp Lys Ile Pro Leu Leu Gln Gln Pro Lys Arg Glu Glu Glu Glu Val 
    370                 375                 380                 


Leu Asp Gln Asp Phe His Met Glu Glu Ala Leu Asp Trp Pro Gly Val 
385                 390                 395                 400 


Tyr Leu Leu Pro Gly Gln Val Ser Gly Val Ala Leu Asp Pro Lys Asn 
                405                 410                 415     


Asn Leu Val Ile Phe His Arg Gly Asp His Val Trp Asp Gly Asn Ser 
            420                 425                 430         


Phe Asp Ser Lys Phe Val Tyr Gln Gln Ile Gly Leu Gly Pro Ile Glu 
        435                 440                 445             


Glu Asp Thr Ile Leu Val Ile Asp Pro Asn Asn Ala Ala Val Leu Gln 
    450                 455                 460                 


Ser Ser Gly Lys Asn Leu Phe Tyr Leu Pro His Gly Leu Ser Ile Asp 
465                 470                 475                 480 


Lys Asp Gly Asn Tyr Trp Val Thr Asp Val Ala Leu His Gln Val Phe 
                485                 490                 495     


Lys Leu Asp Pro Asn Asn Lys Glu Gly Pro Val Leu Ile Leu Gly Arg 
            500                 505                 510         


Ser Met Gln Pro Gly Ser Asp Gln Asn His Phe Cys Gln Pro Thr Asp 
        515                 520                 525             


Val Ala Val Asp Pro Gly Thr Gly Ala Ile Tyr Val Ser Asp Gly Tyr 
    530                 535                 540                 


Cys Asn Ser Arg Ile Val Gln Phe Ser Pro Ser Gly Lys Phe Ile Thr 
545                 550                 555                 560 


Gln Trp Gly Glu Glu Ser Ser Gly Ser Ser Pro Leu Pro Gly Gln Phe 
                565                 570                 575     


Thr Val Pro His Ser Leu Ala Leu Val Pro Leu Leu Gly Gln Leu Cys 
            580                 585                 590         


Val Ala Asp Arg Glu Asn Gly Arg Ile Gln Cys Phe Lys Thr Asp Thr 
        595                 600                 605             


Lys Glu Phe Val Arg Glu Ile Lys His Ser Ser Phe Gly Arg Asn Val 
    610                 615                 620                 


Phe Ala Ile Ser Tyr Ile Pro Gly Leu Leu Phe Ala Val Asn Gly Lys 
625                 630                 635                 640 


Pro His Phe Gly Asp Gln Glu Pro Val Gln Gly Phe Val Met Asn Phe 
                645                 650                 655     


Ser Asn Gly Glu Ile Ile Asp Ile Phe Lys Pro Val Arg Lys His Phe 
            660                 665                 670         


Asp Met Pro His Asp Ile Val Ala Ser Glu Asp Gly Thr Val Tyr Ile 
        675                 680                 685             


Gly Asp Ala His Thr Asn Thr Val Trp Lys Phe Thr Leu Thr Glu Lys 
    690                 695                 700                 


Leu Glu His Arg Ser Val Lys Lys Ala Gly Ile Glu Val Gln Glu Ile 
705                 710                 715                 720 


Lys Glu Ala Glu Ala Val Val Glu Thr Lys Met Glu Asn Lys Pro Thr 
                725                 730                 735     


Ser Ser Glu Leu Gln Lys Met Gln Glu Lys Gln Lys Leu Ile Lys Glu 
            740                 745                 750         


Pro Gly Ser Gly Val Pro Val Val Leu Ile Thr Thr Leu Leu Val Ile 
        755                 760                 765             


Pro Val Val Val Leu Leu Ala Ile Ala Ile Phe Ile Arg Trp Lys Lys 
    770                 775                 780                 


Ser Arg Ala Phe Gly Asp Ser Glu His Lys Leu Glu Thr Ser Ser Gly 
785                 790                 795                 800 


Arg Val Leu Gly Arg Phe Arg Gly Lys Gly Ser Gly Gly Leu Asn Leu 
                805                 810                 815     


Gly Asn Phe Phe Ala Ser Arg Lys Gly Tyr Ser Arg Lys Gly Phe Asp 
            820                 825                 830         


Arg Leu Ser Thr Glu Gly Ser Asp Gln Glu Lys Glu Asp Asp Gly Ser 
        835                 840                 845             


Glu Ser Glu Glu Glu Tyr Ser Ala Pro Leu Pro Ala Leu Ala Pro Ser 
    850                 855                 860                 


Ser Ser 
865     


<210>  374
<211>  973
<212>  PRT
<213>  Homo sapiens

<400>  374

Met Ala Gly Arg Val Pro Ser Leu Leu Val Leu Leu Val Phe Pro Ser 
1               5                   10                  15      


Ser Cys Leu Ala Phe Arg Ser Pro Leu Ser Val Phe Lys Arg Phe Lys 
            20                  25                  30          


Glu Thr Thr Arg Pro Phe Ser Asn Glu Cys Leu Gly Thr Thr Arg Pro 
        35                  40                  45              


Val Val Pro Ile Asp Ser Ser Asp Phe Ala Leu Asp Ile Arg Met Pro 
    50                  55                  60                  


Gly Val Thr Pro Lys Gln Ser Asp Thr Tyr Phe Cys Met Ser Met Arg 
65                  70                  75                  80  


Ile Pro Val Asp Glu Glu Ala Phe Val Ile Asp Phe Lys Pro Arg Ala 
                85                  90                  95      


Ser Met Asp Thr Val His His Met Leu Leu Phe Gly Cys Asn Met Pro 
            100                 105                 110         


Ser Ser Thr Gly Ser Tyr Trp Phe Cys Asp Glu Gly Thr Cys Thr Asp 
        115                 120                 125             


Lys Ala Asn Ile Leu Tyr Ala Trp Ala Arg Asn Ala Pro Pro Thr Arg 
    130                 135                 140                 


Leu Pro Lys Gly Val Gly Phe Arg Val Gly Gly Glu Thr Gly Ser Lys 
145                 150                 155                 160 


Tyr Phe Val Leu Gln Val His Tyr Gly Asp Ile Ser Ala Phe Arg Asp 
                165                 170                 175     


Asn Asn Lys Asp Cys Ser Gly Val Ser Leu His Leu Thr Arg Leu Pro 
            180                 185                 190         


Gln Pro Leu Ile Ala Gly Met Tyr Leu Met Met Ser Val Asp Thr Val 
        195                 200                 205             


Ile Pro Ala Gly Glu Lys Val Val Asn Ser Asp Ile Ser Cys His Tyr 
    210                 215                 220                 


Lys Asn Tyr Pro Met His Val Phe Ala Tyr Arg Val His Thr His His 
225                 230                 235                 240 


Leu Gly Lys Val Val Ser Gly Tyr Arg Val Arg Asn Gly Gln Trp Thr 
                245                 250                 255     


Leu Ile Gly Arg Gln Ser Pro Gln Leu Pro Gln Ala Phe Tyr Pro Val 
            260                 265                 270         


Gly His Pro Val Asp Val Ser Phe Gly Asp Leu Leu Ala Ala Arg Cys 
        275                 280                 285             


Val Phe Thr Gly Glu Gly Arg Thr Glu Ala Thr His Ile Gly Gly Thr 
    290                 295                 300                 


Ser Ser Asp Glu Met Cys Asn Leu Tyr Ile Met Tyr Tyr Met Glu Ala 
305                 310                 315                 320 


Lys His Ala Val Ser Phe Met Thr Cys Thr Gln Asn Val Ala Pro Asp 
                325                 330                 335     


Met Phe Arg Thr Ile Pro Pro Glu Ala Asn Ile Pro Ile Pro Val Lys 
            340                 345                 350         


Ser Asp Met Val Met Met His Glu His His Lys Glu Thr Glu Tyr Lys 
        355                 360                 365             


Asp Lys Ile Pro Leu Leu Gln Gln Pro Lys Arg Glu Glu Glu Glu Val 
    370                 375                 380                 


Leu Asp Gln Gly Asp Phe Tyr Ser Leu Leu Ser Lys Leu Leu Gly Glu 
385                 390                 395                 400 


Arg Glu Asp Val Val His Val His Lys Tyr Asn Pro Thr Glu Lys Ala 
                405                 410                 415     


Glu Ser Glu Ser Asp Leu Val Ala Glu Ile Ala Asn Val Val Gln Lys 
            420                 425                 430         


Lys Asp Leu Gly Arg Ser Asp Ala Arg Glu Gly Ala Glu His Glu Arg 
        435                 440                 445             


Gly Asn Ala Ile Leu Val Arg Asp Arg Ile His Lys Phe His Arg Leu 
    450                 455                 460                 


Val Ser Thr Leu Arg Pro Pro Glu Ser Arg Val Phe Ser Leu Gln Gln 
465                 470                 475                 480 


Pro Pro Pro Gly Glu Gly Thr Trp Glu Pro Glu His Thr Gly Asp Phe 
                485                 490                 495     


His Met Glu Glu Ala Leu Asp Trp Pro Gly Val Tyr Leu Leu Pro Gly 
            500                 505                 510         


Gln Val Ser Gly Val Ala Leu Asp Pro Lys Asn Asn Leu Val Ile Phe 
        515                 520                 525             


His Arg Gly Asp His Val Trp Asp Gly Asn Ser Phe Asp Ser Lys Phe 
    530                 535                 540                 


Val Tyr Gln Gln Ile Gly Leu Gly Pro Ile Glu Glu Asp Thr Ile Leu 
545                 550                 555                 560 


Val Ile Asp Pro Asn Asn Ala Ala Val Leu Gln Ser Ser Gly Lys Asn 
                565                 570                 575     


Leu Phe Tyr Leu Pro His Gly Leu Ser Ile Asp Lys Asp Gly Asn Tyr 
            580                 585                 590         


Trp Val Thr Asp Val Ala Leu His Gln Val Phe Lys Leu Asp Pro Asn 
        595                 600                 605             


Asn Lys Glu Gly Pro Val Leu Ile Leu Gly Arg Ser Met Gln Pro Gly 
    610                 615                 620                 


Ser Asp Gln Asn His Phe Cys Gln Pro Thr Asp Val Ala Val Asp Pro 
625                 630                 635                 640 


Gly Thr Gly Ala Ile Tyr Val Ser Asp Gly Tyr Cys Asn Ser Arg Ile 
                645                 650                 655     


Val Gln Phe Ser Pro Ser Gly Lys Phe Ile Thr Gln Trp Gly Glu Glu 
            660                 665                 670         


Ser Ser Gly Ser Ser Pro Leu Pro Gly Gln Phe Thr Val Pro His Ser 
        675                 680                 685             


Leu Ala Leu Val Pro Leu Leu Gly Gln Leu Cys Val Ala Asp Arg Glu 
    690                 695                 700                 


Asn Gly Arg Ile Gln Cys Phe Lys Thr Asp Thr Lys Glu Phe Val Arg 
705                 710                 715                 720 


Glu Ile Lys His Ser Ser Phe Gly Arg Asn Val Phe Ala Ile Ser Tyr 
                725                 730                 735     


Ile Pro Gly Leu Leu Phe Ala Val Asn Gly Lys Pro His Phe Gly Asp 
            740                 745                 750         


Gln Glu Pro Val Gln Gly Phe Val Met Asn Phe Ser Asn Gly Glu Ile 
        755                 760                 765             


Ile Asp Ile Phe Lys Pro Val Arg Lys His Phe Asp Met Pro His Asp 
    770                 775                 780                 


Ile Val Ala Ser Glu Asp Gly Thr Val Tyr Ile Gly Asp Ala His Thr 
785                 790                 795                 800 


Asn Thr Val Trp Lys Phe Thr Leu Thr Glu Lys Leu Glu His Arg Ser 
                805                 810                 815     


Val Lys Lys Ala Gly Ile Glu Val Gln Glu Ile Lys Glu Ala Glu Ala 
            820                 825                 830         


Val Val Glu Thr Lys Met Glu Asn Lys Pro Thr Ser Ser Glu Leu Gln 
        835                 840                 845             


Lys Met Gln Glu Lys Gln Lys Leu Ile Lys Glu Pro Gly Ser Gly Val 
    850                 855                 860                 


Pro Val Val Leu Ile Thr Thr Leu Leu Val Ile Pro Val Val Val Leu 
865                 870                 875                 880 


Leu Ala Ile Ala Ile Phe Ile Arg Trp Lys Lys Ser Arg Ala Phe Gly 
                885                 890                 895     


Asp Ser Glu His Lys Leu Glu Thr Ser Ser Gly Arg Val Leu Gly Arg 
            900                 905                 910         


Phe Arg Gly Lys Gly Ser Gly Gly Leu Asn Leu Gly Asn Phe Phe Ala 
        915                 920                 925             


Ser Arg Lys Gly Tyr Ser Arg Lys Gly Phe Asp Arg Leu Ser Thr Glu 
    930                 935                 940                 


Gly Ser Asp Gln Glu Lys Glu Asp Asp Gly Ser Glu Ser Glu Glu Glu 
945                 950                 955                 960 


Tyr Ser Ala Pro Leu Pro Ala Leu Ala Pro Ser Ser Ser 
                965                 970             


<210>  375
<211>  905
<212>  PRT
<213>  Homo sapiens

<400>  375

Met Ala Gly Arg Val Pro Ser Leu Leu Val Leu Leu Val Phe Pro Ser 
1               5                   10                  15      


Ser Cys Leu Ala Phe Arg Ser Pro Leu Ser Val Phe Lys Arg Phe Lys 
            20                  25                  30          


Glu Thr Thr Arg Pro Phe Ser Asn Glu Cys Leu Gly Thr Thr Arg Pro 
        35                  40                  45              


Val Val Pro Ile Asp Ser Ser Asp Phe Ala Leu Asp Ile Arg Met Pro 
    50                  55                  60                  


Gly Val Thr Pro Lys Gln Ser Asp Thr Tyr Phe Cys Met Ser Met Arg 
65                  70                  75                  80  


Ile Pro Val Asp Glu Glu Ala Phe Val Ile Asp Phe Lys Pro Arg Ala 
                85                  90                  95      


Ser Met Asp Thr Val His His Met Leu Leu Phe Gly Cys Asn Met Pro 
            100                 105                 110         


Ser Ser Thr Gly Ser Tyr Trp Phe Cys Asp Glu Gly Thr Cys Thr Asp 
        115                 120                 125             


Lys Ala Asn Ile Leu Tyr Ala Trp Ala Arg Asn Ala Pro Pro Thr Arg 
    130                 135                 140                 


Leu Pro Lys Gly Val Gly Phe Arg Val Gly Gly Glu Thr Gly Ser Lys 
145                 150                 155                 160 


Tyr Phe Val Leu Gln Val His Tyr Gly Asp Ile Ser Ala Phe Arg Asp 
                165                 170                 175     


Asn Asn Lys Asp Cys Ser Gly Val Ser Leu His Leu Thr Arg Leu Pro 
            180                 185                 190         


Gln Pro Leu Ile Ala Gly Met Tyr Leu Met Met Ser Val Asp Thr Val 
        195                 200                 205             


Ile Pro Ala Gly Glu Lys Val Val Asn Ser Asp Ile Ser Cys His Tyr 
    210                 215                 220                 


Lys Asn Tyr Pro Met His Val Phe Ala Tyr Arg Val His Thr His His 
225                 230                 235                 240 


Leu Gly Lys Val Val Ser Gly Tyr Arg Val Arg Asn Gly Gln Trp Thr 
                245                 250                 255     


Leu Ile Gly Arg Gln Ser Pro Gln Leu Pro Gln Ala Phe Tyr Pro Val 
            260                 265                 270         


Gly His Pro Val Asp Val Ser Phe Gly Asp Leu Leu Ala Ala Arg Cys 
        275                 280                 285             


Val Phe Thr Gly Glu Gly Arg Thr Glu Ala Thr His Ile Gly Gly Thr 
    290                 295                 300                 


Ser Ser Asp Glu Met Cys Asn Leu Tyr Ile Met Tyr Tyr Met Glu Ala 
305                 310                 315                 320 


Lys His Ala Val Ser Phe Met Thr Cys Thr Gln Asn Val Ala Pro Asp 
                325                 330                 335     


Met Phe Arg Thr Ile Pro Pro Glu Ala Asn Ile Pro Ile Pro Val Lys 
            340                 345                 350         


Ser Asp Met Val Met Met His Glu His His Lys Glu Thr Glu Tyr Lys 
        355                 360                 365             


Asp Lys Ile Pro Leu Leu Gln Gln Pro Lys Arg Glu Glu Glu Glu Val 
    370                 375                 380                 


Leu Asp Gln Gly Asp Phe Tyr Ser Leu Leu Ser Lys Leu Leu Gly Glu 
385                 390                 395                 400 


Arg Glu Asp Val Val His Val His Lys Tyr Asn Pro Thr Glu Lys Ala 
                405                 410                 415     


Glu Ser Glu Ser Asp Leu Val Ala Glu Ile Ala Asn Val Val Gln Lys 
            420                 425                 430         


Lys Asp Leu Gly Arg Ser Asp Ala Arg Glu Gly Ala Glu His Glu Arg 
        435                 440                 445             


Gly Asn Ala Ile Leu Val Arg Asp Arg Ile His Lys Phe His Arg Leu 
    450                 455                 460                 


Val Ser Thr Leu Arg Pro Pro Glu Ser Arg Val Phe Ser Leu Gln Gln 
465                 470                 475                 480 


Pro Pro Pro Gly Glu Gly Thr Trp Glu Pro Glu His Thr Gly Asp Phe 
                485                 490                 495     


His Met Glu Glu Ala Leu Asp Trp Pro Gly Val Tyr Leu Leu Pro Gly 
            500                 505                 510         


Gln Val Ser Gly Val Ala Leu Asp Pro Lys Asn Asn Leu Val Ile Phe 
        515                 520                 525             


His Arg Gly Asp His Val Trp Asp Gly Asn Ser Phe Asp Ser Lys Phe 
    530                 535                 540                 


Val Tyr Gln Gln Ile Gly Leu Gly Pro Ile Glu Glu Asp Thr Ile Leu 
545                 550                 555                 560 


Val Ile Asp Pro Asn Asn Ala Ala Val Leu Gln Ser Ser Gly Lys Asn 
                565                 570                 575     


Leu Phe Tyr Leu Pro His Gly Leu Ser Ile Asp Lys Asp Gly Asn Tyr 
            580                 585                 590         


Trp Val Thr Asp Val Ala Leu His Gln Val Phe Lys Leu Asp Pro Asn 
        595                 600                 605             


Asn Lys Glu Gly Pro Val Leu Ile Leu Gly Arg Ser Met Gln Pro Gly 
    610                 615                 620                 


Ser Asp Gln Asn His Phe Cys Gln Pro Thr Asp Val Ala Val Asp Pro 
625                 630                 635                 640 


Gly Thr Gly Ala Ile Tyr Val Ser Asp Gly Tyr Cys Asn Ser Arg Ile 
                645                 650                 655     


Val Gln Phe Ser Pro Ser Gly Lys Phe Ile Thr Gln Trp Gly Glu Glu 
            660                 665                 670         


Ser Ser Gly Ser Ser Pro Leu Pro Gly Gln Phe Thr Val Pro His Ser 
        675                 680                 685             


Leu Ala Leu Val Pro Leu Leu Gly Gln Leu Cys Val Ala Asp Arg Glu 
    690                 695                 700                 


Asn Gly Arg Ile Gln Cys Phe Lys Thr Asp Thr Lys Glu Phe Val Arg 
705                 710                 715                 720 


Glu Ile Lys His Ser Ser Phe Gly Arg Asn Val Phe Ala Ile Ser Tyr 
                725                 730                 735     


Ile Pro Gly Leu Leu Phe Ala Val Asn Gly Lys Pro His Phe Gly Asp 
            740                 745                 750         


Gln Glu Pro Val Gln Gly Phe Val Met Asn Phe Ser Asn Gly Glu Ile 
        755                 760                 765             


Ile Asp Ile Phe Lys Pro Val Arg Lys His Phe Asp Met Pro His Asp 
    770                 775                 780                 


Ile Val Ala Ser Glu Asp Gly Thr Val Tyr Ile Gly Asp Ala His Thr 
785                 790                 795                 800 


Asn Thr Val Trp Lys Phe Thr Leu Thr Glu Lys Leu Glu His Arg Ser 
                805                 810                 815     


Val Lys Lys Ala Gly Ile Glu Val Gln Glu Ile Lys Asp Ser Glu His 
            820                 825                 830         


Lys Leu Glu Thr Ser Ser Gly Arg Val Leu Gly Arg Phe Arg Gly Lys 
        835                 840                 845             


Gly Ser Gly Gly Leu Asn Leu Gly Asn Phe Phe Ala Ser Arg Lys Gly 
    850                 855                 860                 


Tyr Ser Arg Lys Gly Phe Asp Arg Leu Ser Thr Glu Gly Ser Asp Gln 
865                 870                 875                 880 


Glu Lys Glu Asp Asp Gly Ser Glu Ser Glu Glu Glu Tyr Ser Ala Pro 
                885                 890                 895     


Leu Pro Ala Leu Ala Pro Ser Ser Ser 
            900                 905 


<210>  376
<211>  250
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  376

Xaa Arg Ile Gln Cys Phe Lys Thr Asp Thr Lys Glu Phe Val Arg Glu 
1               5                   10                  15      


Ile Lys His Ser Ser Phe Gly Arg Asn Val Phe Ala Ile Ser Tyr Ile 
            20                  25                  30          


Pro Gly Leu Leu Phe Ala Val Asn Gly Lys Pro His Phe Gly Asp Gln 
        35                  40                  45              


Glu Pro Val Gln Gly Phe Val Met Asn Phe Ser Asn Gly Glu Ile Ile 
    50                  55                  60                  


Asp Ile Phe Lys Pro Val Arg Lys His Phe Asp Met Pro His Asp Ile 
65                  70                  75                  80  


Val Ala Ser Glu Asp Gly Thr Val Tyr Ile Gly Asp Ala His Thr Asn 
                85                  90                  95      


Thr Val Trp Lys Phe Thr Leu Thr Glu Lys Leu Glu His Arg Ser Val 
            100                 105                 110         


Lys Lys Ala Gly Ile Glu Val Gln Glu Ile Lys Glu Ala Glu Ala Val 
        115                 120                 125             


Val Glu Thr Lys Met Glu Asn Lys Pro Thr Ser Ser Glu Leu Gln Lys 
    130                 135                 140                 


Met Gln Glu Lys Gln Lys Leu Ile Lys Glu Pro Gly Ser Gly Val Pro 
145                 150                 155                 160 


Val Val Leu Ile Thr Thr Leu Leu Val Ile Pro Val Val Val Leu Leu 
                165                 170                 175     


Ala Ile Ala Ile Phe Ile Arg Trp Lys Lys Ser Arg Ala Phe Gly Gly 
            180                 185                 190         


Lys Gly Ser Gly Gly Leu Asn Leu Gly Asn Phe Phe Ala Ser Arg Lys 
        195                 200                 205             


Gly Tyr Ser Arg Lys Gly Phe Asp Arg Leu Ser Thr Glu Gly Ser Asp 
    210                 215                 220                 


Gln Glu Lys Glu Asp Asp Gly Ser Glu Ser Glu Glu Glu Tyr Ser Ala 
225                 230                 235                 240 


Pro Leu Pro Ala Leu Ala Pro Ser Ser Ser 
                245                 250 


<210>  377
<211>  29
<212>  PRT
<213>  Homo sapiens

<400>  377

Met Ala Gly Arg Val Pro Ser Leu Leu Val Leu Leu Val Phe Pro Ser 
1               5                   10                  15      


Ser Cys Leu Ala Phe Arg Ser Pro Leu Ser Val Phe Lys 
            20                  25                  


<210>  378
<211>  28
<212>  PRT
<213>  Homo sapiens

<400>  378

Met Ala Gly Arg Val Pro Ser Leu Leu Val Leu Leu Val Phe Pro Ser 
1               5                   10                  15      


Ser Cys Leu Ala Phe Arg Ser Pro Leu Ser Val Phe 
            20                  25              


<210>  379
<211>  53
<212>  PRT
<213>  Homo sapiens

<400>  379

Met Ala Gly Arg Val Pro Ser Leu Leu Val Leu Leu Val Phe Pro Ser 
1               5                   10                  15      


Ser Cys Leu Ala Phe Arg Ser Pro Leu Ser Val Phe Lys Arg Phe Lys 
            20                  25                  30          


Glu Thr Thr Arg Pro Phe Ser Asn Glu Cys Leu Gly Thr Thr Arg Pro 
        35                  40                  45              


Val Val Pro Ile Asp 
    50              


<210>  380
<211>  42
<212>  PRT
<213>  Homo sapiens

<400>  380

Met Ala Gly Arg Val Pro Ser Leu Leu Val Leu Leu Val Phe Pro Ser 
1               5                   10                  15      


Ser Cys Leu Ala Phe Arg Ser Pro Leu Ser Val Phe Lys Arg Phe Lys 
            20                  25                  30          


Glu Thr Thr Arg Pro Phe Ser Asn Glu Cys 
        35                  40          


<210>  381
<211>  68
<212>  PRT
<213>  Homo sapiens

<400>  381

Met Ala Gly Arg Val Pro Ser Leu Leu Val Leu Leu Val Phe Pro Ser 
1               5                   10                  15      


Ser Cys Leu Ala Phe Arg Ser Pro Leu Ser Val Phe Lys Arg Phe Lys 
            20                  25                  30          


Glu Thr Thr Arg Pro Phe Ser Asn Glu Cys Leu Gly Thr Thr Arg Pro 
        35                  40                  45              


Val Val Pro Ile Asp Ser Ser Asp Phe Ala Leu Asp Ile Arg Met Pro 
    50                  55                  60                  


Gly Val Thr Pro 
65              


<210>  382
<211>  25
<212>  PRT
<213>  Homo sapiens

<400>  382

Met Ala Gly Arg Val Pro Ser Leu Leu Val Leu Leu Val Phe Pro Ser 
1               5                   10                  15      


Ser Cys Leu Ala Phe Arg Ser Pro Leu 
            20                  25  


<210>  383
<211>  691
<212>  PRT
<213>  Homo sapiens

<400>  383

Met Met Arg Asn His Arg Ile Ala Ser Ser Leu Cys Gly Asp Gln Val 
1               5                   10                  15      


Phe Ser Lys Lys Lys Lys Lys Lys Lys Lys Asn Asn Met Ala Ala Lys 
            20                  25                  30          


Glu Lys Leu Glu Ala Val Leu Asn Val Ala Leu Arg Val Pro Ser Ile 
        35                  40                  45              


Met Leu Leu Asp Val Leu Tyr Arg Trp Asp Val Ser Ser Phe Phe Gln 
    50                  55                  60                  


Gln Ile Gln Arg Ser Ser Leu Ser Asn Asn Pro Leu Phe Gln Tyr Lys 
65                  70                  75                  80  


Tyr Leu Ala Leu Asn Met His Tyr Val Gly Tyr Ile Leu Ser Val Val 
                85                  90                  95      


Leu Leu Thr Leu Pro Arg Gln His Leu Val Gln Leu Tyr Leu Tyr Phe 
            100                 105                 110         


Leu Thr Ala Leu Leu Leu Tyr Ala Gly His Gln Ile Ser Arg Asp Tyr 
        115                 120                 125             


Val Arg Ser Glu Leu Glu Phe Ala Tyr Glu Gly Pro Met Tyr Leu Glu 
    130                 135                 140                 


Pro Leu Ser Met Asn Arg Phe Thr Thr Ala Leu Ile Gly Gln Leu Val 
145                 150                 155                 160 


Val Cys Thr Leu Cys Ser Cys Val Met Lys Thr Lys Gln Ile Trp Leu 
                165                 170                 175     


Phe Ser Ala His Met Leu Pro Leu Leu Ala Arg Leu Cys Leu Val Pro 
            180                 185                 190         


Leu Glu Thr Ile Val Ile Ile Asn Lys Phe Ala Met Ile Phe Thr Gly 
        195                 200                 205             


Leu Glu Val Leu Tyr Phe Leu Gly Ser Asn Leu Leu Val Pro Tyr Asn 
    210                 215                 220                 


Leu Ala Lys Ser Ala Tyr Arg Glu Leu Val Gln Val Val Glu Val Tyr 
225                 230                 235                 240 


Gly Leu Leu Ala Leu Gly Met Ser Leu Trp Asn Gln Leu Val Val Pro 
                245                 250                 255     


Val Leu Phe Met Val Phe Trp Leu Val Leu Phe Ala Leu Gln Ile Tyr 
            260                 265                 270         


Ser Tyr Phe Ser Thr Arg Asp Gln Pro Ala Ser Arg Glu Arg Leu Leu 
        275                 280                 285             


Phe Leu Phe Leu Thr Ser Ile Ala Glu Cys Cys Ser Thr Pro Tyr Ser 
    290                 295                 300                 


Leu Leu Gly Leu Val Phe Thr Val Ser Phe Val Ala Leu Gly Val Leu 
305                 310                 315                 320 


Thr Leu Cys Lys Phe Tyr Leu Gln Gly Tyr Arg Ala Phe Met Asn Asp 
                325                 330                 335     


Pro Ala Met Asn Arg Gly Met Thr Glu Gly Val Thr Leu Leu Ile Leu 
            340                 345                 350         


Ala Val Gln Thr Gly Leu Ile Glu Leu Gln Val Val His Arg Ala Phe 
        355                 360                 365             


Leu Leu Ser Ile Ile Leu Phe Ile Val Val Ala Ser Ile Leu Gln Ser 
    370                 375                 380                 


Met Leu Glu Ile Ala Asp Pro Ile Val Leu Ala Leu Gly Ala Ser Arg 
385                 390                 395                 400 


Asp Lys Ser Leu Trp Lys His Phe Arg Ala Val Ser Leu Cys Leu Phe 
                405                 410                 415     


Leu Leu Val Phe Pro Ala Tyr Met Ala Tyr Met Ile Cys Gln Phe Phe 
            420                 425                 430         


His Met Asp Phe Trp Leu Leu Ile Ile Ile Ser Ser Ser Ile Leu Thr 
        435                 440                 445             


Ser Leu Gln Val Leu Gly Thr Leu Phe Ile Tyr Val Leu Phe Met Val 
    450                 455                 460                 


Glu Glu Phe Arg Lys Glu Pro Val Glu Asn Met Asp Asp Val Ile Tyr 
465                 470                 475                 480 


Tyr Val Asn Gly Thr Tyr Arg Leu Leu Glu Phe Leu Val Ala Leu Cys 
                485                 490                 495     


Val Val Ala Tyr Gly Val Ser Glu Thr Ile Phe Gly Glu Trp Thr Val 
            500                 505                 510         


Met Gly Ser Met Ile Ile Phe Ile His Ser Tyr Tyr Asn Val Trp Leu 
        515                 520                 525             


Arg Ala Gln Leu Gly Trp Lys Ser Phe Leu Leu Arg Arg Asp Ala Val 
    530                 535                 540                 


Asn Lys Ile Lys Ser Leu Pro Ile Ala Thr Lys Glu Gln Leu Glu Lys 
545                 550                 555                 560 


His Asn Asp Ile Cys Ala Ile Cys Tyr Gln Asp Met Lys Ser Ala Val 
                565                 570                 575     


Ile Thr Pro Cys Ser His Phe Phe His Ala Gly Cys Leu Lys Lys Trp 
            580                 585                 590         


Leu Tyr Val Gln Glu Thr Cys Pro Leu Cys His Cys His Leu Lys Asn 
        595                 600                 605             


Ser Ser Gln Leu Pro Gly Leu Gly Thr Glu Pro Val Leu Gln Pro His 
    610                 615                 620                 


Ala Gly Ala Glu Gln Asn Val Met Phe Gln Glu Gly Thr Glu Pro Pro 
625                 630                 635                 640 


Gly Gln Glu His Thr Pro Gly Thr Arg Ile Gln Glu Gly Ser Arg Asp 
                645                 650                 655     


Asn Asn Glu Tyr Ile Ala Arg Arg Pro Asp Asn Gln Glu Gly Ala Phe 
            660                 665                 670         


Asp Pro Lys Glu Tyr Pro His Ser Ala Lys Asp Glu Ala His Pro Val 
        675                 680                 685             


Glu Ser Ala 
    690     


<210>  384
<211>  663
<212>  PRT
<213>  Homo sapiens

<400>  384

Met Ala Ala Lys Glu Lys Leu Glu Ala Val Leu Asn Val Ala Leu Arg 
1               5                   10                  15      


Val Pro Ser Ile Met Leu Leu Asp Val Leu Tyr Arg Trp Asp Val Ser 
            20                  25                  30          


Ser Phe Phe Gln Gln Ile Gln Arg Ser Ser Leu Ser Asn Asn Pro Leu 
        35                  40                  45              


Phe Gln Tyr Lys Tyr Leu Ala Leu Asn Met His Tyr Val Gly Tyr Ile 
    50                  55                  60                  


Leu Ser Val Val Leu Leu Thr Leu Pro Arg Gln His Leu Val Gln Leu 
65                  70                  75                  80  


Tyr Leu Tyr Phe Leu Thr Ala Leu Leu Leu Tyr Ala Gly His Gln Ile 
                85                  90                  95      


Ser Arg Asp Tyr Val Arg Ser Glu Leu Glu Phe Ala Tyr Glu Gly Pro 
            100                 105                 110         


Met Tyr Leu Glu Pro Leu Ser Met Asn Arg Phe Thr Thr Ala Leu Ile 
        115                 120                 125             


Gly Gln Leu Val Val Cys Thr Leu Cys Ser Cys Val Met Lys Thr Lys 
    130                 135                 140                 


Gln Ile Trp Leu Phe Ser Ala His Met Leu Pro Leu Leu Ala Arg Leu 
145                 150                 155                 160 


Cys Leu Val Pro Leu Glu Thr Ile Val Ile Ile Asn Lys Phe Ala Met 
                165                 170                 175     


Ile Phe Thr Gly Leu Glu Val Leu Tyr Phe Leu Gly Ser Asn Leu Leu 
            180                 185                 190         


Val Pro Tyr Asn Leu Ala Lys Ser Ala Tyr Arg Glu Leu Val Gln Val 
        195                 200                 205             


Val Glu Val Tyr Gly Leu Leu Ala Leu Gly Met Ser Leu Trp Asn Gln 
    210                 215                 220                 


Leu Val Val Pro Val Leu Phe Met Val Phe Trp Leu Val Leu Phe Ala 
225                 230                 235                 240 


Leu Gln Ile Tyr Ser Tyr Phe Ser Thr Arg Asp Gln Pro Ala Ser Arg 
                245                 250                 255     


Glu Arg Leu Leu Phe Leu Phe Leu Thr Ser Ile Ala Glu Cys Cys Ser 
            260                 265                 270         


Thr Pro Tyr Ser Leu Leu Gly Leu Val Phe Thr Val Ser Phe Val Ala 
        275                 280                 285             


Leu Gly Val Leu Thr Leu Cys Lys Phe Tyr Leu Gln Gly Tyr Arg Ala 
    290                 295                 300                 


Phe Met Asn Asp Pro Ala Met Asn Arg Gly Met Thr Glu Gly Val Thr 
305                 310                 315                 320 


Leu Leu Ile Leu Ala Val Gln Thr Gly Leu Ile Glu Leu Gln Val Val 
                325                 330                 335     


His Arg Ala Phe Leu Leu Ser Ile Ile Leu Phe Ile Val Val Ala Ser 
            340                 345                 350         


Ile Leu Gln Ser Met Leu Glu Ile Ala Asp Pro Ile Val Leu Ala Leu 
        355                 360                 365             


Gly Ala Ser Arg Asp Lys Ser Leu Trp Lys His Phe Arg Ala Val Ser 
    370                 375                 380                 


Leu Cys Leu Phe Leu Leu Val Phe Pro Ala Tyr Met Ala Tyr Met Ile 
385                 390                 395                 400 


Cys Gln Phe Phe His Met Asp Phe Trp Leu Leu Ile Ile Ile Ser Ser 
                405                 410                 415     


Ser Ile Leu Thr Ser Leu Gln Val Leu Gly Thr Leu Phe Ile Tyr Val 
            420                 425                 430         


Leu Phe Met Val Glu Glu Phe Arg Lys Glu Pro Val Glu Asn Met Asp 
        435                 440                 445             


Asp Val Ile Tyr Tyr Val Asn Gly Thr Tyr Arg Leu Leu Glu Phe Leu 
    450                 455                 460                 


Val Ala Leu Cys Val Val Ala Tyr Gly Val Ser Glu Thr Ile Phe Gly 
465                 470                 475                 480 


Glu Trp Thr Val Met Gly Ser Met Ile Ile Phe Ile His Ser Tyr Tyr 
                485                 490                 495     


Asn Val Trp Leu Arg Ala Gln Leu Gly Trp Lys Ser Phe Leu Leu Arg 
            500                 505                 510         


Arg Asp Ala Val Asn Lys Ile Lys Ser Leu Pro Ile Ala Thr Lys Glu 
        515                 520                 525             


Gln Leu Glu Lys His Asn Asp Ile Cys Ala Ile Cys Tyr Gln Asp Met 
    530                 535                 540                 


Lys Ser Ala Val Ile Thr Pro Cys Ser His Phe Phe His Ala Gly Cys 
545                 550                 555                 560 


Leu Lys Lys Trp Leu Tyr Val Gln Glu Thr Cys Pro Leu Cys His Cys 
                565                 570                 575     


His Leu Lys Asn Ser Ser Gln Leu Pro Gly Leu Gly Thr Glu Pro Val 
            580                 585                 590         


Leu Gln Pro His Ala Gly Ala Glu Gln Asn Val Met Phe Gln Glu Gly 
        595                 600                 605             


Thr Glu Pro Pro Gly Gln Glu His Thr Pro Gly Thr Arg Ile Gln Glu 
    610                 615                 620                 


Gly Ser Arg Asp Asn Asn Glu Tyr Ile Ala Arg Arg Pro Asp Asn Gln 
625                 630                 635                 640 


Glu Gly Ala Phe Asp Pro Lys Glu Tyr Pro His Ser Ala Lys Asp Glu 
                645                 650                 655     


Ala His Pro Val Glu Ser Ala 
            660             


<210>  385
<211>  693
<212>  PRT
<213>  Homo sapiens

<400>  385

Met His Arg Asp Arg Ile Ser Pro Ser Asn Ser Pro Thr Trp Ser Leu 
1               5                   10                  15      


Gln Val Phe Ser Lys Lys Lys Lys Lys Lys Lys Lys Asn Asn Met Ala 
            20                  25                  30          


Ala Lys Glu Lys Leu Glu Ala Val Leu Asn Val Ala Leu Arg Val Pro 
        35                  40                  45              


Ser Ile Met Leu Leu Asp Val Leu Tyr Arg Trp Asp Val Ser Ser Phe 
    50                  55                  60                  


Phe Gln Gln Ile Gln Arg Ser Ser Leu Ser Asn Asn Pro Leu Phe Gln 
65                  70                  75                  80  


Tyr Lys Tyr Leu Ala Leu Asn Met His Tyr Val Gly Tyr Ile Leu Ser 
                85                  90                  95      


Val Val Leu Leu Thr Leu Pro Arg Gln His Leu Val Gln Leu Tyr Leu 
            100                 105                 110         


Tyr Phe Leu Thr Ala Leu Leu Leu Tyr Ala Gly His Gln Ile Ser Arg 
        115                 120                 125             


Asp Tyr Val Arg Ser Glu Leu Glu Phe Ala Tyr Glu Gly Pro Met Tyr 
    130                 135                 140                 


Leu Glu Pro Leu Ser Met Asn Arg Phe Thr Thr Ala Leu Ile Gly Gln 
145                 150                 155                 160 


Leu Val Val Cys Thr Leu Cys Ser Cys Val Met Lys Thr Lys Gln Ile 
                165                 170                 175     


Trp Leu Phe Ser Ala His Met Leu Pro Leu Leu Ala Arg Leu Cys Leu 
            180                 185                 190         


Val Pro Leu Glu Thr Ile Val Ile Ile Asn Lys Phe Ala Met Ile Phe 
        195                 200                 205             


Thr Gly Leu Glu Val Leu Tyr Phe Leu Gly Ser Asn Leu Leu Val Pro 
    210                 215                 220                 


Tyr Asn Leu Ala Lys Ser Ala Tyr Arg Glu Leu Val Gln Val Val Glu 
225                 230                 235                 240 


Val Tyr Gly Leu Leu Ala Leu Gly Met Ser Leu Trp Asn Gln Leu Val 
                245                 250                 255     


Val Pro Val Leu Phe Met Val Phe Trp Leu Val Leu Phe Ala Leu Gln 
            260                 265                 270         


Ile Tyr Ser Tyr Phe Ser Thr Arg Asp Gln Pro Ala Ser Arg Glu Arg 
        275                 280                 285             


Leu Leu Phe Leu Phe Leu Thr Ser Ile Ala Glu Cys Cys Ser Thr Pro 
    290                 295                 300                 


Tyr Ser Leu Leu Gly Leu Val Phe Thr Val Ser Phe Val Ala Leu Gly 
305                 310                 315                 320 


Val Leu Thr Leu Cys Lys Phe Tyr Leu Gln Gly Tyr Arg Ala Phe Met 
                325                 330                 335     


Asn Asp Pro Ala Met Asn Arg Gly Met Thr Glu Gly Val Thr Leu Leu 
            340                 345                 350         


Ile Leu Ala Val Gln Thr Gly Leu Ile Glu Leu Gln Val Val His Arg 
        355                 360                 365             


Ala Phe Leu Leu Ser Ile Ile Leu Phe Ile Val Val Ala Ser Ile Leu 
    370                 375                 380                 


Gln Ser Met Leu Glu Ile Ala Asp Pro Ile Val Leu Ala Leu Gly Ala 
385                 390                 395                 400 


Ser Arg Asp Lys Ser Leu Trp Lys His Phe Arg Ala Val Ser Leu Cys 
                405                 410                 415     


Leu Phe Leu Leu Val Phe Pro Ala Tyr Met Ala Tyr Met Ile Cys Gln 
            420                 425                 430         


Phe Phe His Met Asp Phe Trp Leu Leu Ile Ile Ile Ser Ser Ser Ile 
        435                 440                 445             


Leu Thr Ser Leu Gln Val Leu Gly Thr Leu Phe Ile Tyr Val Leu Phe 
    450                 455                 460                 


Met Val Glu Glu Phe Arg Lys Glu Pro Val Glu Asn Met Asp Asp Val 
465                 470                 475                 480 


Ile Tyr Tyr Val Asn Gly Thr Tyr Arg Leu Leu Glu Phe Leu Val Ala 
                485                 490                 495     


Leu Cys Val Val Ala Tyr Gly Val Ser Glu Thr Ile Phe Gly Glu Trp 
            500                 505                 510         


Thr Val Met Gly Ser Met Ile Ile Phe Ile His Ser Tyr Tyr Asn Val 
        515                 520                 525             


Trp Leu Arg Ala Gln Leu Gly Trp Lys Ser Phe Leu Leu Arg Arg Asp 
    530                 535                 540                 


Ala Val Asn Lys Ile Lys Ser Leu Pro Ile Ala Thr Lys Glu Gln Leu 
545                 550                 555                 560 


Glu Lys His Asn Asp Ile Cys Ala Ile Cys Tyr Gln Asp Met Lys Ser 
                565                 570                 575     


Ala Val Ile Thr Pro Cys Ser His Phe Phe His Ala Gly Cys Leu Lys 
            580                 585                 590         


Lys Trp Leu Tyr Val Gln Glu Thr Cys Pro Leu Cys His Cys His Leu 
        595                 600                 605             


Lys Asn Ser Ser Gln Leu Pro Gly Leu Gly Thr Glu Pro Val Leu Gln 
    610                 615                 620                 


Pro His Ala Gly Ala Glu Gln Asn Val Met Phe Gln Glu Gly Thr Glu 
625                 630                 635                 640 


Pro Pro Gly Gln Glu His Thr Pro Gly Thr Arg Ile Gln Glu Gly Ser 
                645                 650                 655     


Arg Asp Asn Asn Glu Tyr Ile Ala Arg Arg Pro Asp Asn Gln Glu Gly 
            660                 665                 670         


Ala Phe Asp Pro Lys Glu Tyr Pro His Ser Ala Lys Asp Glu Ala His 
        675                 680                 685             


Pro Val Glu Ser Ala 
    690             


<210>  386
<211>  663
<212>  PRT
<213>  Homo sapiens

<400>  386

Met Ala Ala Lys Glu Lys Leu Glu Ala Val Leu Asn Val Ala Leu Arg 
1               5                   10                  15      


Val Pro Ser Ile Met Leu Leu Asp Val Leu Tyr Arg Trp Asp Val Ser 
            20                  25                  30          


Ser Phe Phe Gln Gln Ile Gln Arg Ser Ser Leu Ser Asn Asn Pro Leu 
        35                  40                  45              


Phe Gln Tyr Lys Tyr Leu Ala Leu Asn Met His Tyr Val Gly Tyr Ile 
    50                  55                  60                  


Leu Ser Val Val Leu Leu Thr Leu Pro Arg Gln His Leu Val Gln Leu 
65                  70                  75                  80  


Tyr Leu Tyr Phe Leu Thr Ala Leu Leu Leu Tyr Ala Gly His Gln Ile 
                85                  90                  95      


Ser Arg Asp Tyr Val Arg Ser Glu Leu Glu Phe Ala Tyr Glu Gly Pro 
            100                 105                 110         


Met Tyr Leu Glu Pro Leu Ser Met Asn Arg Phe Thr Thr Ala Leu Ile 
        115                 120                 125             


Gly Gln Leu Val Val Cys Thr Leu Cys Ser Cys Val Met Lys Thr Lys 
    130                 135                 140                 


Gln Ile Trp Leu Phe Ser Ala His Met Leu Pro Leu Leu Ala Arg Leu 
145                 150                 155                 160 


Cys Leu Val Pro Leu Glu Thr Ile Val Ile Ile Asn Lys Phe Ala Met 
                165                 170                 175     


Ile Phe Thr Gly Leu Glu Val Leu Tyr Phe Leu Gly Ser Asn Leu Leu 
            180                 185                 190         


Val Pro Tyr Asn Leu Ala Lys Ser Ala Tyr Arg Glu Leu Val Gln Val 
        195                 200                 205             


Val Glu Val Tyr Gly Leu Leu Ala Leu Gly Met Ser Leu Trp Asn Gln 
    210                 215                 220                 


Leu Val Val Pro Val Leu Phe Met Val Phe Trp Leu Val Leu Phe Ala 
225                 230                 235                 240 


Leu Gln Ile Tyr Ser Tyr Phe Ser Thr Arg Asp Gln Pro Ala Ser Arg 
                245                 250                 255     


Glu Arg Leu Leu Phe Leu Phe Leu Thr Ser Ile Ala Glu Cys Cys Ser 
            260                 265                 270         


Thr Pro Tyr Ser Leu Leu Gly Leu Val Phe Thr Val Ser Phe Val Ala 
        275                 280                 285             


Leu Gly Val Leu Thr Leu Cys Lys Phe Tyr Leu Gln Gly Tyr Arg Ala 
    290                 295                 300                 


Phe Met Asn Asp Pro Ala Met Asn Arg Gly Met Thr Glu Gly Val Thr 
305                 310                 315                 320 


Leu Leu Ile Leu Ala Val Gln Thr Gly Leu Ile Glu Leu Gln Val Val 
                325                 330                 335     


His Arg Ala Phe Leu Leu Ser Ile Ile Leu Phe Ile Val Val Ala Ser 
            340                 345                 350         


Ile Leu Gln Ser Met Leu Glu Ile Ala Asp Pro Ile Val Leu Ala Leu 
        355                 360                 365             


Gly Ala Ser Arg Asp Lys Ser Leu Trp Lys His Phe Arg Ala Val Ser 
    370                 375                 380                 


Leu Cys Leu Phe Leu Leu Val Phe Pro Ala Tyr Met Ala Tyr Met Ile 
385                 390                 395                 400 


Cys Gln Phe Phe His Met Asp Phe Trp Leu Leu Ile Ile Ile Ser Ser 
                405                 410                 415     


Ser Ile Leu Thr Ser Leu Gln Val Leu Gly Thr Leu Phe Ile Tyr Val 
            420                 425                 430         


Leu Phe Met Val Glu Glu Phe Arg Lys Glu Pro Val Glu Asn Met Asp 
        435                 440                 445             


Asp Val Ile Tyr Tyr Val Asn Gly Thr Tyr Arg Leu Leu Glu Phe Leu 
    450                 455                 460                 


Val Ala Leu Cys Val Val Ala Tyr Gly Val Ser Glu Thr Ile Phe Gly 
465                 470                 475                 480 


Glu Trp Thr Val Met Gly Ser Met Ile Ile Phe Ile His Ser Tyr Tyr 
                485                 490                 495     


Asn Val Trp Leu Arg Ala Gln Leu Gly Trp Lys Ser Phe Leu Leu Arg 
            500                 505                 510         


Arg Asp Ala Val Asn Lys Ile Lys Ser Leu Pro Ile Ala Thr Lys Glu 
        515                 520                 525             


Gln Leu Glu Lys His Asn Asp Ile Cys Ala Ile Cys Tyr Gln Asp Met 
    530                 535                 540                 


Lys Ser Ala Val Ile Thr Pro Cys Ser His Phe Phe His Ala Gly Cys 
545                 550                 555                 560 


Leu Lys Lys Trp Leu Tyr Val Gln Glu Thr Cys Pro Leu Cys His Cys 
                565                 570                 575     


His Leu Lys Asn Ser Ser Gln Leu Pro Gly Leu Gly Thr Glu Pro Val 
            580                 585                 590         


Leu Gln Pro His Ala Gly Ala Glu Gln Asn Val Met Phe Gln Glu Gly 
        595                 600                 605             


Thr Glu Pro Pro Gly Gln Glu His Thr Pro Gly Thr Arg Ile Gln Glu 
    610                 615                 620                 


Gly Ser Arg Asp Asn Asn Glu Tyr Ile Ala Arg Arg Pro Asp Asn Gln 
625                 630                 635                 640 


Glu Gly Ala Phe Asp Pro Lys Glu Tyr Pro His Ser Ala Lys Asp Glu 
                645                 650                 655     


Ala His Pro Val Glu Ser Ala 
            660             


<210>  387
<211>  677
<212>  PRT
<213>  Homo sapiens

<400>  387

Met Val Phe Ser Lys Lys Lys Lys Lys Lys Lys Lys Asn Asn Met Ala 
1               5                   10                  15      


Ala Lys Glu Lys Leu Glu Ala Val Leu Asn Val Ala Leu Arg Val Pro 
            20                  25                  30          


Ser Ile Met Leu Leu Asp Val Leu Tyr Arg Trp Asp Val Ser Ser Phe 
        35                  40                  45              


Phe Gln Gln Ile Gln Arg Ser Ser Leu Ser Asn Asn Pro Leu Phe Gln 
    50                  55                  60                  


Tyr Lys Tyr Leu Ala Leu Asn Met His Tyr Val Gly Tyr Ile Leu Ser 
65                  70                  75                  80  


Val Val Leu Leu Thr Leu Pro Arg Gln His Leu Val Gln Leu Tyr Leu 
                85                  90                  95      


Tyr Phe Leu Thr Ala Leu Leu Leu Tyr Ala Gly His Gln Ile Ser Arg 
            100                 105                 110         


Asp Tyr Val Arg Ser Glu Leu Glu Phe Ala Tyr Glu Gly Pro Met Tyr 
        115                 120                 125             


Leu Glu Pro Leu Ser Met Asn Arg Phe Thr Thr Ala Leu Ile Gly Gln 
    130                 135                 140                 


Leu Val Val Cys Thr Leu Cys Ser Cys Val Met Lys Thr Lys Gln Ile 
145                 150                 155                 160 


Trp Leu Phe Ser Ala His Met Leu Pro Leu Leu Ala Arg Leu Cys Leu 
                165                 170                 175     


Val Pro Leu Glu Thr Ile Val Ile Ile Asn Lys Phe Ala Met Ile Phe 
            180                 185                 190         


Thr Gly Leu Glu Val Leu Tyr Phe Leu Gly Ser Asn Leu Leu Val Pro 
        195                 200                 205             


Tyr Asn Leu Ala Lys Ser Ala Tyr Arg Glu Leu Val Gln Val Val Glu 
    210                 215                 220                 


Val Tyr Gly Leu Leu Ala Leu Gly Met Ser Leu Trp Asn Gln Leu Val 
225                 230                 235                 240 


Val Pro Val Leu Phe Met Val Phe Trp Leu Val Leu Phe Ala Leu Gln 
                245                 250                 255     


Ile Tyr Ser Tyr Phe Ser Thr Arg Asp Gln Pro Ala Ser Arg Glu Arg 
            260                 265                 270         


Leu Leu Phe Leu Phe Leu Thr Ser Ile Ala Glu Cys Cys Ser Thr Pro 
        275                 280                 285             


Tyr Ser Leu Leu Gly Leu Val Phe Thr Val Ser Phe Val Ala Leu Gly 
    290                 295                 300                 


Val Leu Thr Leu Cys Lys Phe Tyr Leu Gln Gly Tyr Arg Ala Phe Met 
305                 310                 315                 320 


Asn Asp Pro Ala Met Asn Arg Gly Met Thr Glu Gly Val Thr Leu Leu 
                325                 330                 335     


Ile Leu Ala Val Gln Thr Gly Leu Ile Glu Leu Gln Val Val His Arg 
            340                 345                 350         


Ala Phe Leu Leu Ser Ile Ile Leu Phe Ile Val Val Ala Ser Ile Leu 
        355                 360                 365             


Gln Ser Met Leu Glu Ile Ala Asp Pro Ile Val Leu Ala Leu Gly Ala 
    370                 375                 380                 


Ser Arg Asp Lys Ser Leu Trp Lys His Phe Arg Ala Val Ser Leu Cys 
385                 390                 395                 400 


Leu Phe Leu Leu Val Phe Pro Ala Tyr Met Ala Tyr Met Ile Cys Gln 
                405                 410                 415     


Phe Phe His Met Asp Phe Trp Leu Leu Ile Ile Ile Ser Ser Ser Ile 
            420                 425                 430         


Leu Thr Ser Leu Gln Val Leu Gly Thr Leu Phe Ile Tyr Val Leu Phe 
        435                 440                 445             


Met Val Glu Glu Phe Arg Lys Glu Pro Val Glu Asn Met Asp Asp Val 
    450                 455                 460                 


Ile Tyr Tyr Val Asn Gly Thr Tyr Arg Leu Leu Glu Phe Leu Val Ala 
465                 470                 475                 480 


Leu Cys Val Val Ala Tyr Gly Val Ser Glu Thr Ile Phe Gly Glu Trp 
                485                 490                 495     


Thr Val Met Gly Ser Met Ile Ile Phe Ile His Ser Tyr Tyr Asn Val 
            500                 505                 510         


Trp Leu Arg Ala Gln Leu Gly Trp Lys Ser Phe Leu Leu Arg Arg Asp 
        515                 520                 525             


Ala Val Asn Lys Ile Lys Ser Leu Pro Ile Ala Thr Lys Glu Gln Leu 
    530                 535                 540                 


Glu Lys His Asn Asp Ile Cys Ala Ile Cys Tyr Gln Asp Met Lys Ser 
545                 550                 555                 560 


Ala Val Ile Thr Pro Cys Ser His Phe Phe His Ala Gly Cys Leu Lys 
                565                 570                 575     


Lys Trp Leu Tyr Val Gln Glu Thr Cys Pro Leu Cys His Cys His Leu 
            580                 585                 590         


Lys Asn Ser Ser Gln Leu Pro Gly Leu Gly Thr Glu Pro Val Leu Gln 
        595                 600                 605             


Pro His Ala Gly Ala Glu Gln Asn Val Met Phe Gln Glu Gly Thr Glu 
    610                 615                 620                 


Pro Pro Gly Gln Glu His Thr Pro Gly Thr Arg Ile Gln Glu Gly Ser 
625                 630                 635                 640 


Arg Asp Asn Asn Glu Tyr Ile Ala Arg Arg Pro Asp Asn Gln Glu Gly 
                645                 650                 655     


Ala Phe Asp Pro Lys Glu Tyr Pro His Ser Ala Lys Asp Glu Ala His 
            660                 665                 670         


Pro Val Glu Ser Ala 
        675         


<210>  388
<211>  680
<212>  PRT
<213>  Homo sapiens

<400>  388

Met Ala Glu Val Val Phe Ser Lys Lys Lys Lys Lys Lys Lys Lys Asn 
1               5                   10                  15      


Asn Met Ala Ala Lys Glu Lys Leu Glu Ala Val Leu Asn Val Ala Leu 
            20                  25                  30          


Arg Val Pro Ser Ile Met Leu Leu Asp Val Leu Tyr Arg Trp Asp Val 
        35                  40                  45              


Ser Ser Phe Phe Gln Gln Ile Gln Arg Ser Ser Leu Ser Asn Asn Pro 
    50                  55                  60                  


Leu Phe Gln Tyr Lys Tyr Leu Ala Leu Asn Met His Tyr Val Gly Tyr 
65                  70                  75                  80  


Ile Leu Ser Val Val Leu Leu Thr Leu Pro Arg Gln His Leu Val Gln 
                85                  90                  95      


Leu Tyr Leu Tyr Phe Leu Thr Ala Leu Leu Leu Tyr Ala Gly His Gln 
            100                 105                 110         


Ile Ser Arg Asp Tyr Val Arg Ser Glu Leu Glu Phe Ala Tyr Glu Gly 
        115                 120                 125             


Pro Met Tyr Leu Glu Pro Leu Ser Met Asn Arg Phe Thr Thr Ala Leu 
    130                 135                 140                 


Ile Gly Gln Leu Val Val Cys Thr Leu Cys Ser Cys Val Met Lys Thr 
145                 150                 155                 160 


Lys Gln Ile Trp Leu Phe Ser Ala His Met Leu Pro Leu Leu Ala Arg 
                165                 170                 175     


Leu Cys Leu Val Pro Leu Glu Thr Ile Val Ile Ile Asn Lys Phe Ala 
            180                 185                 190         


Met Ile Phe Thr Gly Leu Glu Val Leu Tyr Phe Leu Gly Ser Asn Leu 
        195                 200                 205             


Leu Val Pro Tyr Asn Leu Ala Lys Ser Ala Tyr Arg Glu Leu Val Gln 
    210                 215                 220                 


Val Val Glu Val Tyr Gly Leu Leu Ala Leu Gly Met Ser Leu Trp Asn 
225                 230                 235                 240 


Gln Leu Val Val Pro Val Leu Phe Met Val Phe Trp Leu Val Leu Phe 
                245                 250                 255     


Ala Leu Gln Ile Tyr Ser Tyr Phe Ser Thr Arg Asp Gln Pro Ala Ser 
            260                 265                 270         


Arg Glu Arg Leu Leu Phe Leu Phe Leu Thr Ser Ile Ala Glu Cys Cys 
        275                 280                 285             


Ser Thr Pro Tyr Ser Leu Leu Gly Leu Val Phe Thr Val Ser Phe Val 
    290                 295                 300                 


Ala Leu Gly Val Leu Thr Leu Cys Lys Phe Tyr Leu Gln Gly Tyr Arg 
305                 310                 315                 320 


Ala Phe Met Asn Asp Pro Ala Met Asn Arg Gly Met Thr Glu Gly Val 
                325                 330                 335     


Thr Leu Leu Ile Leu Ala Val Gln Thr Gly Leu Ile Glu Leu Gln Val 
            340                 345                 350         


Val His Arg Ala Phe Leu Leu Ser Ile Ile Leu Phe Ile Val Val Ala 
        355                 360                 365             


Ser Ile Leu Gln Ser Met Leu Glu Ile Ala Asp Pro Ile Val Leu Ala 
    370                 375                 380                 


Leu Gly Ala Ser Arg Asp Lys Ser Leu Trp Lys His Phe Arg Ala Val 
385                 390                 395                 400 


Ser Leu Cys Leu Phe Leu Leu Val Phe Pro Ala Tyr Met Ala Tyr Met 
                405                 410                 415     


Ile Cys Gln Phe Phe His Met Asp Phe Trp Leu Leu Ile Ile Ile Ser 
            420                 425                 430         


Ser Ser Ile Leu Thr Ser Leu Gln Val Leu Gly Thr Leu Phe Ile Tyr 
        435                 440                 445             


Val Leu Phe Met Val Glu Glu Phe Arg Lys Glu Pro Val Glu Asn Met 
    450                 455                 460                 


Asp Asp Val Ile Tyr Tyr Val Asn Gly Thr Tyr Arg Leu Leu Glu Phe 
465                 470                 475                 480 


Leu Val Ala Leu Cys Val Val Ala Tyr Gly Val Ser Glu Thr Ile Phe 
                485                 490                 495     


Gly Glu Trp Thr Val Met Gly Ser Met Ile Ile Phe Ile His Ser Tyr 
            500                 505                 510         


Tyr Asn Val Trp Leu Arg Ala Gln Leu Gly Trp Lys Ser Phe Leu Leu 
        515                 520                 525             


Arg Arg Asp Ala Val Asn Lys Ile Lys Ser Leu Pro Ile Ala Thr Lys 
    530                 535                 540                 


Glu Gln Leu Glu Lys His Asn Asp Ile Cys Ala Ile Cys Tyr Gln Asp 
545                 550                 555                 560 


Met Lys Ser Ala Val Ile Thr Pro Cys Ser His Phe Phe His Ala Gly 
                565                 570                 575     


Cys Leu Lys Lys Trp Leu Tyr Val Gln Glu Thr Cys Pro Leu Cys His 
            580                 585                 590         


Cys His Leu Lys Asn Ser Ser Gln Leu Pro Gly Leu Gly Thr Glu Pro 
        595                 600                 605             


Val Leu Gln Pro His Ala Gly Ala Glu Gln Asn Val Met Phe Gln Glu 
    610                 615                 620                 


Gly Thr Glu Pro Pro Gly Gln Glu His Thr Pro Gly Thr Arg Ile Gln 
625                 630                 635                 640 


Glu Gly Ser Arg Asp Asn Asn Glu Tyr Ile Ala Arg Arg Pro Asp Asn 
                645                 650                 655     


Gln Glu Gly Ala Phe Asp Pro Lys Glu Tyr Pro His Ser Ala Lys Asp 
            660                 665                 670         


Glu Ala His Pro Val Glu Ser Ala 
        675                 680 


<210>  389
<211>  663
<212>  PRT
<213>  Homo sapiens

<400>  389

Met Ala Ala Lys Glu Lys Leu Glu Ala Val Leu Asn Val Ala Leu Arg 
1               5                   10                  15      


Val Pro Ser Ile Met Leu Leu Asp Val Leu Tyr Arg Trp Asp Val Ser 
            20                  25                  30          


Ser Phe Phe Gln Gln Ile Gln Arg Ser Ser Leu Ser Asn Asn Pro Leu 
        35                  40                  45              


Phe Gln Tyr Lys Tyr Leu Ala Leu Asn Met His Tyr Val Gly Tyr Ile 
    50                  55                  60                  


Leu Ser Val Val Leu Leu Thr Leu Pro Arg Gln His Leu Val Gln Leu 
65                  70                  75                  80  


Tyr Leu Tyr Phe Leu Thr Ala Leu Leu Leu Tyr Ala Gly His Gln Ile 
                85                  90                  95      


Ser Arg Asp Tyr Val Arg Ser Glu Leu Glu Phe Ala Tyr Glu Gly Pro 
            100                 105                 110         


Met Tyr Leu Glu Pro Leu Ser Met Asn Arg Phe Thr Thr Ala Leu Ile 
        115                 120                 125             


Gly Gln Leu Val Val Cys Thr Leu Cys Ser Cys Val Met Lys Thr Lys 
    130                 135                 140                 


Gln Ile Trp Leu Phe Ser Ala His Met Leu Pro Leu Leu Ala Arg Leu 
145                 150                 155                 160 


Cys Leu Val Pro Leu Glu Thr Ile Val Ile Ile Asn Lys Phe Ala Met 
                165                 170                 175     


Ile Phe Thr Gly Leu Glu Val Leu Tyr Phe Leu Gly Ser Asn Leu Leu 
            180                 185                 190         


Val Pro Tyr Asn Leu Ala Lys Ser Ala Tyr Arg Glu Leu Val Gln Val 
        195                 200                 205             


Val Glu Val Tyr Gly Leu Leu Ala Leu Gly Met Ser Leu Trp Asn Gln 
    210                 215                 220                 


Leu Val Val Pro Val Leu Phe Met Val Phe Trp Leu Val Leu Phe Ala 
225                 230                 235                 240 


Leu Gln Ile Tyr Ser Tyr Phe Ser Thr Arg Asp Gln Pro Ala Ser Arg 
                245                 250                 255     


Glu Arg Leu Leu Phe Leu Phe Leu Thr Ser Ile Ala Glu Cys Cys Ser 
            260                 265                 270         


Thr Pro Tyr Ser Leu Leu Gly Leu Val Phe Thr Val Ser Phe Val Ala 
        275                 280                 285             


Leu Gly Val Leu Thr Leu Cys Lys Phe Tyr Leu Gln Gly Tyr Arg Ala 
    290                 295                 300                 


Phe Met Asn Asp Pro Ala Met Asn Arg Gly Met Thr Glu Gly Val Thr 
305                 310                 315                 320 


Leu Leu Ile Leu Ala Val Gln Thr Gly Leu Ile Glu Leu Gln Val Val 
                325                 330                 335     


His Arg Ala Phe Leu Leu Ser Ile Ile Leu Phe Ile Val Val Ala Ser 
            340                 345                 350         


Ile Leu Gln Ser Met Leu Glu Ile Ala Asp Pro Ile Val Leu Ala Leu 
        355                 360                 365             


Gly Ala Ser Arg Asp Lys Ser Leu Trp Lys His Phe Arg Ala Val Ser 
    370                 375                 380                 


Leu Cys Leu Phe Leu Leu Val Phe Pro Ala Tyr Met Ala Tyr Met Ile 
385                 390                 395                 400 


Cys Gln Phe Phe His Met Asp Phe Trp Leu Leu Ile Ile Ile Ser Ser 
                405                 410                 415     


Ser Ile Leu Thr Ser Leu Gln Val Leu Gly Thr Leu Phe Ile Tyr Val 
            420                 425                 430         


Leu Phe Met Val Glu Glu Phe Arg Lys Glu Pro Val Glu Asn Met Asp 
        435                 440                 445             


Asp Val Ile Tyr Tyr Val Asn Gly Thr Tyr Arg Leu Leu Glu Phe Leu 
    450                 455                 460                 


Val Ala Leu Cys Val Val Ala Tyr Gly Val Ser Glu Thr Ile Phe Gly 
465                 470                 475                 480 


Glu Trp Thr Val Met Gly Ser Met Ile Ile Phe Ile His Ser Tyr Tyr 
                485                 490                 495     


Asn Val Trp Leu Arg Ala Gln Leu Gly Trp Lys Ser Phe Leu Leu Arg 
            500                 505                 510         


Arg Asp Ala Val Asn Lys Ile Lys Ser Leu Pro Ile Ala Thr Lys Glu 
        515                 520                 525             


Gln Leu Glu Lys His Asn Asp Ile Cys Ala Ile Cys Tyr Gln Asp Met 
    530                 535                 540                 


Lys Ser Ala Val Ile Thr Pro Cys Ser His Phe Phe His Ala Gly Cys 
545                 550                 555                 560 


Leu Lys Lys Trp Leu Tyr Val Gln Glu Thr Cys Pro Leu Cys His Cys 
                565                 570                 575     


His Leu Lys Asn Ser Ser Gln Leu Pro Gly Leu Gly Thr Glu Pro Val 
            580                 585                 590         


Leu Gln Pro His Ala Gly Ala Glu Gln Asn Val Met Phe Gln Glu Gly 
        595                 600                 605             


Thr Glu Pro Pro Gly Gln Glu His Thr Pro Gly Thr Arg Ile Gln Glu 
    610                 615                 620                 


Gly Ser Arg Asp Asn Asn Glu Tyr Ile Ala Arg Arg Pro Asp Asn Gln 
625                 630                 635                 640 


Glu Gly Ala Phe Asp Pro Lys Glu Tyr Pro His Ser Ala Lys Asp Glu 
                645                 650                 655     


Ala His Pro Val Glu Ser Ala 
            660             


<210>  390
<211>  185
<212>  PRT
<213>  Homo sapiens

<400>  390

Met Ala Gly Pro Arg Pro Arg Trp Arg Asp Gln Leu Leu Phe Met Ser 
1               5                   10                  15      


Ile Ile Val Leu Val Ile Val Val Ile Cys Leu Met Phe Tyr Ala Leu 
            20                  25                  30          


Leu Trp Glu Ala Gly Asn Leu Thr Asp Leu Pro Asn Leu Arg Ile Gly 
        35                  40                  45              


Phe Tyr Asn Phe Cys Leu Trp Asn Glu Asp Thr Ser Thr Leu Gln Cys 
    50                  55                  60                  


His Gln Phe Pro Glu Leu Glu Ala Leu Gly Val Pro Arg Val Gly Leu 
65                  70                  75                  80  


Gly Leu Ala Arg Leu Gly Val Tyr Gly Ser Leu Val Leu Thr Leu Phe 
                85                  90                  95      


Ala Pro Gln Pro Leu Leu Leu Ala Gln Cys Asn Ser Asp Glu Arg Ala 
            100                 105                 110         


Trp Arg Leu Ala Val Gly Phe Leu Ala Val Ser Ser Val Leu Leu Ala 
        115                 120                 125             


Gly Gly Leu Gly Leu Phe Leu Ser Tyr Val Trp Lys Trp Val Arg Leu 
    130                 135                 140                 


Ser Leu Pro Gly Pro Gly Phe Leu Ala Leu Gly Ser Ala Gln Ala Leu 
145                 150                 155                 160 


Leu Ile Leu Leu Leu Ile Ala Met Ala Val Phe Pro Leu Arg Ala Glu 
                165                 170                 175     


Arg Ala Glu Ser Lys Leu Glu Ser Cys 
            180                 185 


<210>  391
<211>  486
<212>  PRT
<213>  Homo sapiens

<400>  391

Met Lys Gly Arg Arg Arg Arg Arg Arg Glu Tyr Cys Lys Phe Ala Leu 
1               5                   10                  15      


Leu Leu Val Leu Tyr Thr Leu Val Leu Leu Leu Val Pro Ser Val Leu 
            20                  25                  30          


Asp Gly Gly Arg Asp Gly Asp Lys Gly Ala Glu His Cys Pro Gly Leu 
        35                  40                  45              


Gln Arg Ser Leu Gly Val Trp Ser Leu Glu Ala Ala Ala Ala Gly Glu 
    50                  55                  60                  


Arg Glu Gln Gly Ala Glu Ala Arg Ala Ala Glu Glu Gly Gly Ala Asn 
65                  70                  75                  80  


Gln Ser Pro Arg Phe Pro Ser Asn Leu Ser Gly Ala Val Gly Glu Ala 
                85                  90                  95      


Val Ser Arg Glu Lys Gln His Ile Tyr Val His Ala Thr Trp Arg Thr 
            100                 105                 110         


Gly Ser Ser Phe Leu Gly Glu Leu Phe Asn Gln His Pro Asp Val Phe 
        115                 120                 125             


Tyr Leu Tyr Glu Pro Met Trp His Leu Trp Gln Ala Leu Tyr Pro Gly 
    130                 135                 140                 


Asp Ala Glu Ser Leu Gln Gly Ala Leu Arg Asp Met Leu Arg Ser Leu 
145                 150                 155                 160 


Phe Arg Cys Asp Phe Ser Val Leu Arg Leu Tyr Ala Pro Pro Gly Asp 
                165                 170                 175     


Pro Ala Ala Arg Ala Pro Asp Thr Ala Asn Leu Thr Thr Ala Ala Leu 
            180                 185                 190         


Phe Arg Trp Arg Thr Asn Lys Val Ile Cys Ser Pro Pro Leu Cys Pro 
        195                 200                 205             


Gly Ala Pro Arg Ala Arg Ala Glu Val Gly Leu Val Glu Asp Thr Ala 
    210                 215                 220                 


Cys Glu Arg Ser Cys Pro Pro Val Ala Ile Arg Ala Leu Glu Ala Glu 
225                 230                 235                 240 


Cys Arg Lys Tyr Pro Val Val Val Ile Lys Asp Val Arg Leu Leu Asp 
                245                 250                 255     


Leu Gly Val Leu Val Pro Leu Leu Arg Asp Pro Gly Leu Asn Leu Lys 
            260                 265                 270         


Val Val Gln Leu Phe Arg Asp Pro Arg Ala Val His Asn Ser Arg Leu 
        275                 280                 285             


Lys Ser Arg Gln Gly Leu Leu Arg Glu Ser Ile Gln Val Leu Arg Thr 
    290                 295                 300                 


Arg Gln Arg Gly Asp Arg Phe His Arg Val Leu Leu Ala His Gly Val 
305                 310                 315                 320 


Gly Ala Arg Pro Gly Gly Gln Ser Arg Ala Leu Pro Ala Ala Pro Arg 
                325                 330                 335     


Ala Asp Phe Phe Leu Thr Gly Ala Leu Glu Val Ile Cys Glu Ala Trp 
            340                 345                 350         


Leu Arg Asp Leu Leu Phe Ala Arg Gly Ala Pro Ala Trp Leu Arg Arg 
        355                 360                 365             


Arg Tyr Leu Arg Leu Arg Tyr Glu Asp Leu Val Arg Gln Pro Arg Ala 
    370                 375                 380                 


Gln Leu Arg Arg Leu Leu Arg Phe Ser Gly Leu Arg Ala Leu Ala Ala 
385                 390                 395                 400 


Leu Asp Ala Phe Ala Leu Asn Met Thr Arg Gly Ala Ala Tyr Gly Ala 
                405                 410                 415     


Asp Arg Pro Phe His Leu Ser Ala Arg Asp Ala Arg Glu Ala Val His 
            420                 425                 430         


Ala Trp Arg Glu Arg Leu Ser Arg Glu Gln Val Arg Gln Val Glu Ala 
        435                 440                 445             


Ala Cys Ala Pro Ala Met Arg Leu Leu Ala Tyr Pro Arg Ser Gly Glu 
    450                 455                 460                 


Glu Gly Asp Ala Glu Gln Pro Arg Glu Gly Glu Thr Pro Leu Glu Met 
465                 470                 475                 480 


Asp Ala Asp Gly Ala Thr 
                485     


<210>  392
<211>  494
<212>  PRT
<213>  Homo sapiens

<400>  392

Met Leu Thr Ser Lys Gly Gln Gly Phe Leu His Gly Gly Leu Cys Leu 
1               5                   10                  15      


Trp Leu Cys Val Phe Thr Pro Phe Phe Lys Gly Cys Val Gly Cys Ala 
            20                  25                  30          


Thr Glu Glu Arg Leu Phe His Lys Leu Phe Ser His Tyr Asn Gln Phe 
        35                  40                  45              


Ile Arg Pro Val Glu Asn Val Ser Asp Pro Val Thr Val His Phe Glu 
    50                  55                  60                  


Val Ala Ile Thr Gln Leu Ala Asn Val Asp Glu Val Asn Gln Ile Met 
65                  70                  75                  80  


Glu Thr Asn Leu Trp Leu Arg His Ile Trp Asn Asp Tyr Lys Leu Arg 
                85                  90                  95      


Trp Asp Pro Met Glu Tyr Asp Gly Ile Glu Thr Leu Arg Val Pro Ala 
            100                 105                 110         


Asp Lys Ile Trp Lys Pro Asp Ile Val Leu Tyr Asn Asn Ala Val Gly 
        115                 120                 125             


Asp Phe Gln Val Glu Gly Lys Thr Lys Ala Leu Leu Lys Tyr Asn Gly 
    130                 135                 140                 


Met Ile Thr Trp Thr Pro Pro Ala Ile Phe Lys Ser Ser Cys Pro Met 
145                 150                 155                 160 


Asp Ile Thr Phe Phe Pro Phe Asp His Gln Asn Cys Ser Leu Lys Phe 
                165                 170                 175     


Gly Ser Trp Thr Tyr Asp Lys Ala Glu Ile Asp Leu Leu Ile Ile Gly 
            180                 185                 190         


Ser Lys Val Asp Met Asn Asp Phe Trp Glu Asn Ser Glu Trp Glu Ile 
        195                 200                 205             


Ile Asp Ala Ser Gly Tyr Lys His Asp Ile Lys Tyr Asn Cys Cys Glu 
    210                 215                 220                 


Glu Ile Tyr Thr Asp Ile Thr Tyr Ser Phe Tyr Ile Arg Arg Leu Pro 
225                 230                 235                 240 


Met Phe Tyr Thr Ile Asn Leu Ile Ile Pro Cys Leu Phe Ile Ser Phe 
                245                 250                 255     


Leu Thr Val Leu Val Phe Tyr Leu Pro Ser Asp Cys Gly Glu Lys Val 
            260                 265                 270         


Thr Leu Cys Ile Ser Val Leu Leu Ser Leu Thr Val Phe Leu Leu Val 
        275                 280                 285             


Ile Thr Glu Thr Ile Pro Ser Thr Ser Leu Val Val Pro Leu Val Gly 
    290                 295                 300                 


Glu Tyr Leu Leu Phe Thr Met Ile Phe Val Thr Leu Ser Ile Val Val 
305                 310                 315                 320 


Thr Val Phe Val Leu Asn Ile His Tyr Arg Thr Pro Thr Thr His Thr 
                325                 330                 335     


Met Pro Arg Trp Val Lys Thr Val Phe Leu Lys Leu Leu Pro Gln Val 
            340                 345                 350         


Leu Leu Met Arg Trp Pro Leu Asp Lys Thr Arg Gly Thr Gly Ser Asp 
        355                 360                 365             


Ala Val Pro Arg Gly Leu Ala Arg Arg Pro Ala Lys Gly Lys Leu Ala 
    370                 375                 380                 


Ser His Gly Glu Pro Arg His Leu Lys Glu Cys Phe His Cys His Lys 
385                 390                 395                 400 


Ser Asn Glu Leu Ala Thr Ser Lys Arg Arg Leu Ser His Gln Pro Leu 
                405                 410                 415     


Gln Trp Val Val Glu Asn Ser Glu His Ser Pro Glu Val Glu Asp Val 
            420                 425                 430         


Ile Asn Ser Val Gln Phe Ile Ala Glu Asn Met Lys Ser His Asn Glu 
        435                 440                 445             


Thr Lys Glu Val Glu Asp Asp Trp Lys Tyr Val Ala Met Val Val Asp 
    450                 455                 460                 


Arg Val Phe Leu Trp Val Phe Ile Ile Val Cys Val Phe Gly Thr Ala 
465                 470                 475                 480 


Gly Leu Phe Leu Gln Pro Leu Leu Gly Asn Thr Gly Lys Ser 
                485                 490                 


<210>  393
<211>  111
<212>  PRT
<213>  Homo sapiens

<400>  393

Met Glu Thr Asn Leu Trp Leu Arg His Ile Trp Asn Asp Tyr Lys Leu 
1               5                   10                  15      


Arg Trp Asp Pro Met Glu Tyr Asp Gly Ile Glu Thr Leu Arg Val Pro 
            20                  25                  30          


Ala Asp Lys Ile Trp Lys Pro Asp Ile Val Leu Tyr Asn Asn Ala Val 
        35                  40                  45              


Gly Asp Phe Gln Val Glu Gly Lys Thr Lys Ala Leu Leu Lys Tyr Asn 
    50                  55                  60                  


Gly Met Ile Thr Trp Thr Pro Pro Ala Ile Phe Lys Ser Ser Cys Pro 
65                  70                  75                  80  


Met Asp Ile Thr Phe Phe Pro Phe Asp His Gln Asn Cys Ser Leu Lys 
                85                  90                  95      


Phe Gly Ser Trp Thr Tyr Asp Lys Ala Glu Ile Asp Leu Leu Ile 
            100                 105                 110     


<210>  394
<211>  479
<212>  PRT
<213>  Homo sapiens

<400>  394

Met Leu Thr Ser Lys Gly Gln Gly Phe Leu His Gly Gly Leu Cys Leu 
1               5                   10                  15      


Trp Leu Cys Val Phe Thr Pro Phe Phe Lys Gly Cys Val Gly Cys Ala 
            20                  25                  30          


Thr Glu Glu Arg Leu Phe His Lys Leu Phe Ser His Tyr Asn Gln Phe 
        35                  40                  45              


Ile Arg Pro Val Glu Asn Val Ser Asp Pro Val Thr Val His Phe Glu 
    50                  55                  60                  


Val Ala Ile Thr Gln Leu Ala Asn Val Ile Trp Asn Asp Tyr Lys Leu 
65                  70                  75                  80  


Arg Trp Asp Pro Met Glu Tyr Asp Gly Ile Glu Thr Leu Arg Val Pro 
                85                  90                  95      


Ala Asp Lys Ile Trp Lys Pro Asp Ile Val Leu Tyr Asn Asn Ala Val 
            100                 105                 110         


Gly Asp Phe Gln Val Glu Gly Lys Thr Lys Ala Leu Leu Lys Tyr Asn 
        115                 120                 125             


Gly Met Ile Thr Trp Thr Pro Pro Ala Ile Phe Lys Ser Ser Cys Pro 
    130                 135                 140                 


Met Asp Ile Thr Phe Phe Pro Phe Asp His Gln Asn Cys Ser Leu Lys 
145                 150                 155                 160 


Phe Gly Ser Trp Thr Tyr Asp Lys Ala Glu Ile Asp Leu Leu Ile Ile 
                165                 170                 175     


Gly Ser Lys Val Asp Met Asn Asp Phe Trp Glu Asn Ser Glu Trp Glu 
            180                 185                 190         


Ile Ile Asp Ala Ser Gly Tyr Lys His Asp Ile Lys Tyr Asn Cys Cys 
        195                 200                 205             


Glu Glu Ile Tyr Thr Asp Ile Thr Tyr Ser Phe Tyr Ile Arg Arg Leu 
    210                 215                 220                 


Pro Met Phe Tyr Thr Ile Asn Leu Ile Ile Pro Cys Leu Phe Ile Ser 
225                 230                 235                 240 


Phe Leu Thr Val Leu Val Phe Tyr Leu Pro Ser Asp Cys Gly Glu Lys 
                245                 250                 255     


Val Thr Leu Cys Ile Ser Val Leu Leu Ser Leu Thr Val Phe Leu Leu 
            260                 265                 270         


Val Ile Thr Glu Thr Ile Pro Ser Thr Ser Leu Val Val Pro Leu Val 
        275                 280                 285             


Gly Glu Tyr Leu Leu Phe Thr Met Ile Phe Val Thr Leu Ser Ile Val 
    290                 295                 300                 


Val Thr Val Phe Val Leu Asn Ile His Tyr Arg Thr Pro Thr Thr His 
305                 310                 315                 320 


Thr Met Pro Arg Trp Val Lys Thr Val Phe Leu Lys Leu Leu Pro Gln 
                325                 330                 335     


Val Leu Leu Met Arg Trp Pro Leu Asp Lys Thr Arg Gly Thr Gly Ser 
            340                 345                 350         


Asp Ala Val Pro Arg Gly Leu Ala Arg Arg Pro Ala Lys Gly Lys Leu 
        355                 360                 365             


Ala Ser His Gly Glu Pro Arg His Leu Lys Glu Cys Phe His Cys His 
    370                 375                 380                 


Lys Ser Asn Glu Leu Ala Thr Ser Lys Arg Arg Leu Ser His Gln Pro 
385                 390                 395                 400 


Leu Gln Trp Val Val Glu Asn Ser Glu His Ser Pro Glu Val Glu Asp 
                405                 410                 415     


Val Ile Asn Ser Val Gln Phe Ile Ala Glu Asn Met Lys Ser His Asn 
            420                 425                 430         


Glu Thr Lys Glu Val Glu Asp Asp Trp Lys Tyr Val Ala Met Val Val 
        435                 440                 445             


Asp Arg Val Phe Leu Trp Val Phe Ile Ile Val Cys Val Phe Gly Thr 
    450                 455                 460                 


Ala Gly Leu Phe Leu Gln Pro Leu Leu Gly Asn Thr Gly Lys Ser 
465                 470                 475                 


<210>  395
<211>  1337
<212>  PRT
<213>  Homo sapiens

<400>  395

Met Lys Pro Ala Ala Arg Glu Ala Arg Leu Pro Pro Arg Ser Pro Gly 
1               5                   10                  15      


Leu Arg Trp Ala Leu Pro Leu Leu Leu Leu Leu Leu Arg Leu Gly Gln 
            20                  25                  30          


Ile Leu Cys Ala Gly Gly Thr Pro Ser Pro Ile Pro Asp Pro Ser Val 
        35                  40                  45              


Ala Thr Val Ala Thr Gly Glu Asn Gly Ile Thr Gln Ile Ser Ser Thr 
    50                  55                  60                  


Ala Glu Ser Phe His Lys Gln Asn Gly Thr Gly Thr Pro Gln Val Glu 
65                  70                  75                  80  


Thr Asn Thr Ser Glu Asp Gly Glu Ser Ser Gly Ala Asn Asp Ser Leu 
                85                  90                  95      


Arg Thr Pro Glu Gln Gly Ser Asn Gly Thr Asp Gly Ala Ser Gln Lys 
            100                 105                 110         


Thr Pro Ser Ser Thr Gly Pro Ser Pro Val Phe Asp Ile Lys Ala Val 
        115                 120                 125             


Ser Ile Ser Pro Thr Asn Val Ile Leu Thr Trp Lys Ser Asn Asp Thr 
    130                 135                 140                 


Ala Ala Ser Glu Tyr Lys Tyr Val Val Lys His Lys Met Glu Asn Glu 
145                 150                 155                 160 


Lys Thr Ile Thr Val Val His Gln Pro Trp Cys Asn Ile Thr Gly Leu 
                165                 170                 175     


Arg Pro Ala Thr Ser Tyr Val Phe Ser Ile Thr Pro Gly Ile Gly Asn 
            180                 185                 190         


Glu Thr Trp Gly Asp Pro Arg Val Ile Lys Val Ile Thr Glu Pro Ile 
        195                 200                 205             


Pro Val Ser Asp Leu Arg Val Ala Leu Thr Gly Val Arg Lys Ala Ala 
    210                 215                 220                 


Leu Ser Trp Ser Asn Gly Asn Gly Thr Ala Ser Cys Arg Val Leu Leu 
225                 230                 235                 240 


Glu Ser Ile Gly Ser His Glu Glu Leu Thr Gln Asp Ser Arg Leu Gln 
                245                 250                 255     


Val Asn Ile Ser Gly Leu Lys Pro Gly Val Gln Tyr Asn Ile Asn Pro 
            260                 265                 270         


Tyr Leu Leu Gln Ser Asn Lys Thr Lys Gly Asp Pro Leu Gly Thr Glu 
        275                 280                 285             


Gly Gly Leu Asp Ala Ser Asn Thr Glu Arg Ser Arg Ala Gly Ser Pro 
    290                 295                 300                 


Thr Ala Pro Val His Asp Glu Ser Leu Val Gly Pro Val Asp Pro Ser 
305                 310                 315                 320 


Ser Gly Gln Gln Ser Arg Asp Thr Glu Val Leu Leu Val Gly Leu Glu 
                325                 330                 335     


Pro Gly Thr Arg Tyr Asn Ala Thr Val Tyr Ser Gln Ala Ala Asn Gly 
            340                 345                 350         


Thr Glu Gly Gln Pro Gln Ala Ile Glu Phe Arg Thr Asn Ala Ile Gln 
        355                 360                 365             


Val Phe Asp Val Thr Ala Val Asn Ile Ser Ala Thr Ser Leu Thr Leu 
    370                 375                 380                 


Ile Trp Lys Val Ser Asp Asn Glu Ser Ser Ser Asn Tyr Thr Tyr Lys 
385                 390                 395                 400 


Ile His Val Ala Gly Glu Thr Asp Ser Ser Asn Leu Asn Val Ser Glu 
                405                 410                 415     


Pro Arg Ala Val Ile Pro Gly Leu Arg Ser Ser Thr Phe Tyr Asn Ile 
            420                 425                 430         


Thr Val Cys Pro Val Leu Gly Asp Ile Glu Gly Thr Pro Gly Phe Leu 
        435                 440                 445             


Gln Val His Thr Pro Pro Val Pro Val Ser Asp Phe Arg Val Thr Val 
    450                 455                 460                 


Val Ser Thr Thr Glu Ile Gly Leu Ala Trp Ser Ser His Asp Ala Glu 
465                 470                 475                 480 


Ser Phe Gln Met His Ile Thr Gln Glu Gly Ala Gly Asn Ser Arg Val 
                485                 490                 495     


Glu Ile Thr Thr Asn Gln Ser Ile Ile Ile Gly Gly Leu Phe Pro Gly 
            500                 505                 510         


Thr Lys Tyr Cys Phe Glu Ile Val Pro Lys Gly Pro Asn Gly Thr Glu 
        515                 520                 525             


Gly Ala Ser Arg Thr Val Cys Asn Arg Thr Val Pro Ser Ala Val Phe 
    530                 535                 540                 


Asp Ile His Val Val Tyr Val Thr Thr Thr Glu Met Trp Leu Asp Trp 
545                 550                 555                 560 


Lys Ser Pro Asp Gly Ala Ser Glu Tyr Val Tyr His Leu Val Ile Glu 
                565                 570                 575     


Ser Lys His Gly Ser Asn His Thr Ser Thr Tyr Asp Lys Ala Ile Thr 
            580                 585                 590         


Leu Gln Gly Leu Ile Pro Gly Thr Leu Tyr Asn Ile Thr Ile Ser Pro 
        595                 600                 605             


Glu Val Asp His Val Trp Gly Asp Pro Asn Ser Thr Ala Gln Tyr Thr 
    610                 615                 620                 


Arg Pro Ser Asn Val Ser Asn Ile Asp Val Ser Thr Asn Thr Thr Ala 
625                 630                 635                 640 


Ala Thr Leu Ser Trp Gln Asn Phe Asp Asp Ala Ser Pro Thr Tyr Ser 
                645                 650                 655     


Tyr Cys Leu Leu Ile Glu Lys Ala Gly Asn Ser Ser Asn Ala Thr Gln 
            660                 665                 670         


Val Val Thr Asp Ile Gly Ile Thr Asp Ala Thr Val Thr Glu Leu Ile 
        675                 680                 685             


Pro Gly Ser Ser Tyr Thr Val Glu Ile Phe Ala Gln Val Gly Asp Gly 
    690                 695                 700                 


Ile Lys Ser Leu Glu Pro Gly Arg Lys Ser Phe Cys Thr Asp Pro Ala 
705                 710                 715                 720 


Ser Met Ala Ser Phe Asp Cys Glu Val Val Pro Lys Glu Pro Ala Leu 
                725                 730                 735     


Val Leu Lys Trp Thr Cys Pro Pro Gly Ala Asn Ala Gly Phe Glu Leu 
            740                 745                 750         


Glu Val Ser Ser Gly Ala Trp Asn Asn Ala Thr His Leu Glu Ser Cys 
        755                 760                 765             


Ser Ser Glu Asn Gly Thr Glu Tyr Arg Thr Glu Val Thr Tyr Leu Asn 
    770                 775                 780                 


Phe Ser Thr Ser Tyr Asn Ile Ser Ile Thr Thr Val Ser Cys Gly Lys 
785                 790                 795                 800 


Met Ala Ala Pro Thr Arg Asn Thr Cys Thr Thr Gly Ile Thr Asp Pro 
                805                 810                 815     


Pro Pro Pro Asp Gly Ser Pro Asn Ile Thr Ser Val Ser His Asn Ser 
            820                 825                 830         


Val Lys Val Lys Phe Ser Gly Phe Glu Ala Ser His Gly Pro Ile Lys 
        835                 840                 845             


Ala Tyr Ala Val Ile Leu Thr Thr Gly Glu Ala Gly His Pro Ser Ala 
    850                 855                 860                 


Asp Val Leu Lys Tyr Thr Tyr Glu Asp Phe Lys Lys Gly Ala Ser Asp 
865                 870                 875                 880 


Thr Tyr Val Thr Tyr Leu Ile Arg Thr Glu Glu Lys Gly Arg Ser Gln 
                885                 890                 895     


Ser Leu Ser Glu Val Leu Lys Tyr Glu Ile Asp Val Gly Asn Glu Ser 
            900                 905                 910         


Thr Thr Leu Gly Tyr Tyr Asn Gly Lys Leu Glu Pro Leu Gly Ser Tyr 
        915                 920                 925             


Arg Ala Cys Val Ala Gly Phe Thr Asn Ile Thr Phe His Pro Gln Asn 
    930                 935                 940                 


Lys Gly Leu Ile Asp Gly Ala Glu Ser Tyr Val Ser Phe Ser Arg Tyr 
945                 950                 955                 960 


Ser Asp Ala Val Ser Leu Pro Gln Asp Pro Gly Val Ile Cys Gly Ala 
                965                 970                 975     


Val Phe Gly Cys Ile Phe Gly Ala Leu Val Ile Val Thr Val Gly Gly 
            980                 985                 990         


Phe Ile Phe Trp Arg Lys Lys Arg  Lys Asp Ala Lys Asn  Asn Glu Val 
        995                 1000                 1005             


Ser Phe  Ser Gln Ile Lys Pro  Lys Lys Ser Lys Leu  Ile Arg Val 
    1010                 1015                 1020             


Glu Asn  Phe Glu Ala Tyr Phe  Lys Lys Gln Gln Ala  Asp Ser Asn 
    1025                 1030                 1035             


Cys Gly  Phe Ala Glu Glu Tyr  Glu Asp Leu Lys Leu  Val Gly Ile 
    1040                 1045                 1050             


Ser Gln  Pro Lys Tyr Ala Ala  Glu Leu Ala Glu Asn  Arg Gly Lys 
    1055                 1060                 1065             


Asn Arg  Tyr Asn Asn Val Leu  Pro Tyr Asp Ile Ser  Arg Val Lys 
    1070                 1075                 1080             


Leu Ser  Val Gln Thr His Ser  Thr Asp Asp Tyr Ile  Asn Ala Asn 
    1085                 1090                 1095             


Tyr Met  Pro Gly Tyr His Ser  Lys Lys Asp Phe Ile  Ala Thr Gln 
    1100                 1105                 1110             


Gly Pro  Leu Pro Asn Thr Leu  Lys Asp Phe Trp Arg  Met Val Trp 
    1115                 1120                 1125             


Glu Lys  Asn Val Tyr Ala Ile  Ile Met Leu Thr Lys  Cys Val Glu 
    1130                 1135                 1140             


Gln Gly  Arg Thr Lys Cys Glu  Glu Tyr Trp Pro Ser  Lys Gln Ala 
    1145                 1150                 1155             


Gln Asp  Tyr Gly Asp Ile Thr  Val Ala Met Thr Ser  Glu Ile Val 
    1160                 1165                 1170             


Leu Pro  Glu Trp Thr Ile Arg  Asp Phe Thr Val Lys  Asn Ile Gln 
    1175                 1180                 1185             


Thr Ser  Glu Ser His Pro Leu  Arg Gln Phe His Phe  Thr Ser Trp 
    1190                 1195                 1200             


Pro Asp  His Gly Val Pro Asp  Thr Thr Asp Leu Leu  Ile Asn Phe 
    1205                 1210                 1215             


Arg Tyr  Leu Val Arg Asp Tyr  Met Lys Gln Ser Pro  Pro Glu Ser 
    1220                 1225                 1230             


Pro Ile  Leu Val His Cys Ser  Ala Gly Val Gly Arg  Thr Gly Thr 
    1235                 1240                 1245             


Phe Ile  Ala Ile Asp Arg Leu  Ile Tyr Gln Ile Glu  Asn Glu Asn 
    1250                 1255                 1260             


Thr Val  Asp Val Tyr Gly Ile  Val Tyr Asp Leu Arg  Met His Arg 
    1265                 1270                 1275             


Pro Leu  Met Val Gln Thr Glu  Asp Gln Tyr Val Phe  Leu Asn Gln 
    1280                 1285                 1290             


Cys Val  Leu Asp Ile Val Arg  Ser Gln Lys Asp Ser  Lys Val Asp 
    1295                 1300                 1305             


Leu Ile  Tyr Gln Asn Thr Thr  Ala Met Thr Ile Tyr  Glu Asn Leu 
    1310                 1315                 1320             


Ala Pro  Val Thr Thr Phe Gly  Lys Thr Asn Gly Tyr  Ile Ala 
    1325                 1330                 1335         


<210>  396
<211>  539
<212>  PRT
<213>  Homo sapiens

<400>  396

Met Lys Pro Ala Ala Arg Glu Ala Arg Leu Pro Pro Arg Ser Pro Gly 
1               5                   10                  15      


Leu Arg Trp Ala Leu Pro Leu Leu Leu Leu Leu Leu Arg Leu Gly Gln 
            20                  25                  30          


Ile Leu Cys Ala Gly Gly Thr Pro Ser Pro Ile Pro Asp Pro Ser Val 
        35                  40                  45              


Ala Thr Val Ala Thr Gly Glu Asn Gly Ile Thr Gln Ile Ser Ser Thr 
    50                  55                  60                  


Ala Glu Ser Phe His Lys Gln Asn Gly Thr Gly Thr Pro Gln Val Glu 
65                  70                  75                  80  


Thr Asn Thr Ser Glu Asp Gly Glu Ser Ser Gly Ala Asn Asp Ser Leu 
                85                  90                  95      


Arg Thr Pro Glu Gln Gly Ser Asn Gly Thr Asp Gly Ala Ser Gln Lys 
            100                 105                 110         


Thr Pro Ser Ser Thr Gly Pro Ser Pro Val Phe Asp Ile Lys Ala Val 
        115                 120                 125             


Ser Ile Ser Pro Thr Asn Val Ile Leu Thr Trp Lys Ser Asn Asp Thr 
    130                 135                 140                 


Ala Ala Ser Glu Tyr Lys Tyr Val Val Lys His Lys Met Glu Asn Glu 
145                 150                 155                 160 


Lys Thr Ile Thr Val Val His Gln Pro Trp Cys Asn Ile Thr Gly Leu 
                165                 170                 175     


Arg Pro Ala Thr Ser Tyr Val Phe Ser Ile Thr Pro Gly Ile Gly Asn 
            180                 185                 190         


Glu Thr Trp Gly Asp Pro Arg Val Ile Lys Val Ile Thr Glu Pro Ile 
        195                 200                 205             


Pro Val Ser Asp Leu Arg Val Ala Leu Thr Gly Val Arg Lys Ala Ala 
    210                 215                 220                 


Leu Ser Trp Ser Asn Gly Asn Gly Thr Ala Ser Cys Arg Val Leu Leu 
225                 230                 235                 240 


Glu Ser Ile Gly Ser His Glu Glu Leu Thr Gln Asp Ser Arg Leu Gln 
                245                 250                 255     


Val Asn Ile Ser Gly Leu Lys Pro Gly Val Gln Tyr Asn Ile Asn Pro 
            260                 265                 270         


Tyr Leu Leu Gln Ser Asn Lys Thr Lys Gly Asp Pro Leu Gly Thr Glu 
        275                 280                 285             


Gly Gly Leu Asp Ala Ser Asn Thr Glu Arg Ser Arg Ala Gly Ser Pro 
    290                 295                 300                 


Thr Ala Pro Val His Asp Glu Ser Leu Val Gly Pro Val Asp Pro Ser 
305                 310                 315                 320 


Ser Gly Gln Gln Ser Arg Asp Thr Glu Val Leu Leu Val Gly Leu Glu 
                325                 330                 335     


Pro Gly Thr Arg Tyr Asn Ala Thr Val Tyr Ser Gln Ala Ala Asn Gly 
            340                 345                 350         


Thr Glu Gly Gln Pro Gln Ala Ile Glu Phe Arg Thr Asn Ala Ile Gln 
        355                 360                 365             


Val Phe Asp Val Thr Ala Val Asn Ile Ser Ala Thr Ser Leu Thr Leu 
    370                 375                 380                 


Ile Trp Lys Val Ser Asp Asn Glu Ser Ser Ser Asn Tyr Thr Tyr Lys 
385                 390                 395                 400 


Ile His Val Ala Gly Glu Thr Asp Ser Ser Asn Leu Asn Val Ser Glu 
                405                 410                 415     


Pro Arg Ala Val Ile Pro Gly Leu Arg Ser Ser Thr Phe Tyr Asn Ile 
            420                 425                 430         


Thr Val Cys Pro Val Leu Gly Asp Ile Glu Gly Thr Pro Gly Phe Leu 
        435                 440                 445             


Gln Val His Thr Pro Pro Val Pro Val Ser Asp Phe Arg Val Thr Val 
    450                 455                 460                 


Val Ser Thr Thr Glu Ile Gly Leu Ala Trp Ser Ser His Asp Ala Glu 
465                 470                 475                 480 


Ser Phe Gln Met His Ile Thr Gln Glu Gly Ala Gly Asn Ser Arg Val 
                485                 490                 495     


Glu Ile Thr Thr Asn Gln Ser Ile Ile Ile Gly Gly Leu Phe Pro Gly 
            500                 505                 510         


Thr Lys Tyr Cys Phe Glu Ile Val Pro Lys Gly Pro Asn Gly Thr Glu 
        515                 520                 525             


Gly Ala Ser Arg Thr Val Cys Asn Arg Thr Gly 
    530                 535                 


<210>  397
<211>  147
<212>  PRT
<213>  Homo sapiens

<400>  397

Met Lys Pro Ala Ala Arg Glu Ala Arg Leu Pro Pro Arg Ser Pro Gly 
1               5                   10                  15      


Leu Arg Trp Ala Leu Pro Leu Leu Leu Leu Leu Leu Arg Leu Gly Gln 
            20                  25                  30          


Ile Leu Cys Ala Gly Gly Thr Pro Ser Pro Ile Pro Asp Pro Ser Val 
        35                  40                  45              


Ala Thr Val Ala Thr Gly Glu Asn Gly Ile Thr Gln Ile Ser Ser Thr 
    50                  55                  60                  


Ala Glu Ser Phe His Lys Gln Asn Gly Thr Gly Thr Pro Gln Val Glu 
65                  70                  75                  80  


Thr Asn Thr Ser Glu Asp Gly Glu Ser Ser Gly Ala Asn Asp Ser Leu 
                85                  90                  95      


Arg Thr Pro Glu Gln Gly Ser Asn Gly Thr Asp Gly Ala Ser Gln Lys 
            100                 105                 110         


Thr Pro Ser Ser Thr Glu Pro Ile Pro Val Ser Asp Leu Arg Val Ala 
        115                 120                 125             


Leu Thr Gly Val Arg Lys Ala Ala Leu Ser Trp Ser Asn Gly Asn Gly 
    130                 135                 140                 


Thr Ala Ser 
145         


<210>  398
<211>  120
<212>  PRT
<213>  Homo sapiens

<400>  398

Met Lys Pro Ala Ala Arg Glu Ala Arg Leu Pro Pro Arg Ser Pro Gly 
1               5                   10                  15      


Leu Arg Trp Ala Leu Pro Leu Leu Leu Leu Leu Leu Arg Leu Gly Gln 
            20                  25                  30          


Ile Leu Cys Ala Gly Gly Arg Pro Ser Pro Val Phe Asp Ile Lys Ala 
        35                  40                  45              


Val Ser Ile Ser Pro Thr Asn Val Ile Leu Thr Trp Lys Ser Asn Asp 
    50                  55                  60                  


Thr Ala Ala Ser Glu Tyr Lys Tyr Val Val Lys His Lys Met Glu Asn 
65                  70                  75                  80  


Glu Lys Thr Ile Thr Val Val His Gln Pro Trp Cys Asn Ile Thr Gly 
                85                  90                  95      


Leu Arg Pro Ala Thr Ser Tyr Val Phe Ser Ile Thr Pro Gly Ile Gly 
            100                 105                 110         


Asn Glu Thr Trp Gly Asp Pro Arg 
        115                 120 


<210>  399
<211>  1338
<212>  PRT
<213>  Homo sapiens

<400>  399

Met Lys Pro Ala Ala Arg Glu Ala Arg Leu Pro Pro Arg Ser Pro Gly 
1               5                   10                  15      


Leu Arg Trp Ala Leu Pro Leu Leu Leu Leu Leu Leu Arg Leu Gly Gln 
            20                  25                  30          


Ile Leu Cys Ala Gly Gly Thr Pro Ser Pro Ile Pro Asp Pro Ser Val 
        35                  40                  45              


Ala Thr Val Ala Thr Gly Glu Asn Gly Ile Thr Gln Ile Ser Ser Thr 
    50                  55                  60                  


Ala Glu Ser Phe His Lys Gln Asn Gly Thr Gly Thr Pro Gln Val Glu 
65                  70                  75                  80  


Thr Asn Thr Ser Glu Asp Gly Glu Ser Ser Gly Ala Asn Asp Ser Leu 
                85                  90                  95      


Arg Thr Pro Glu Gln Gly Ser Asn Gly Thr Asp Gly Ala Ser Gln Lys 
            100                 105                 110         


Thr Pro Ser Ser Thr Gly Pro Ser Pro Val Phe Asp Ile Lys Ala Val 
        115                 120                 125             


Ser Ile Ser Pro Thr Asn Val Ile Leu Thr Trp Lys Ser Asn Asp Thr 
    130                 135                 140                 


Ala Ala Ser Glu Tyr Lys Tyr Val Val Lys His Lys Met Glu Asn Glu 
145                 150                 155                 160 


Lys Thr Ile Thr Val Val His Gln Pro Trp Cys Asn Ile Thr Gly Leu 
                165                 170                 175     


Arg Pro Ala Thr Ser Tyr Val Phe Ser Ile Thr Pro Gly Ile Gly Asn 
            180                 185                 190         


Glu Thr Trp Gly Asp Pro Arg Val Ile Lys Val Ile Thr Glu Pro Ile 
        195                 200                 205             


Pro Val Ser Asp Leu Arg Val Ala Leu Thr Gly Val Arg Lys Ala Ala 
    210                 215                 220                 


Leu Ser Trp Ser Asn Gly Asn Gly Thr Ala Ser Cys Arg Val Leu Leu 
225                 230                 235                 240 


Glu Ser Ile Gly Ser His Glu Glu Leu Thr Gln Asp Ser Arg Leu Gln 
                245                 250                 255     


Val Asn Ile Ser Gly Leu Lys Pro Gly Val Gln Tyr Asn Ile Asn Pro 
            260                 265                 270         


Tyr Leu Leu Gln Ser Asn Lys Thr Lys Gly Asp Pro Leu Gly Thr Glu 
        275                 280                 285             


Gly Gly Leu Asp Ala Ser Asn Thr Glu Arg Ser Arg Ala Gly Ser Pro 
    290                 295                 300                 


Thr Ala Pro Val His Asp Glu Ser Leu Val Gly Pro Val Asp Pro Ser 
305                 310                 315                 320 


Ser Gly Gln Gln Ser Arg Asp Thr Glu Val Leu Leu Val Gly Leu Glu 
                325                 330                 335     


Pro Gly Thr Arg Tyr Asn Ala Thr Val Tyr Ser Gln Ala Ala Asn Gly 
            340                 345                 350         


Thr Glu Gly Gln Pro Gln Ala Ile Glu Phe Arg Thr Asn Ala Ile Gln 
        355                 360                 365             


Val Phe Asp Val Thr Ala Val Asn Ile Ser Ala Thr Ser Leu Thr Leu 
    370                 375                 380                 


Ile Trp Lys Val Ser Asp Asn Glu Ser Ser Ser Asn Tyr Thr Tyr Lys 
385                 390                 395                 400 


Ile His Val Ala Gly Glu Thr Asp Ser Ser Asn Leu Asn Val Ser Glu 
                405                 410                 415     


Pro Arg Ala Val Ile Pro Gly Leu Arg Ser Ser Thr Phe Tyr Asn Ile 
            420                 425                 430         


Thr Val Cys Pro Val Leu Gly Asp Ile Glu Gly Thr Pro Gly Phe Leu 
        435                 440                 445             


Gln Val His Thr Pro Pro Val Pro Val Ser Asp Phe Arg Val Thr Val 
    450                 455                 460                 


Val Ser Thr Thr Glu Ile Gly Leu Ala Trp Ser Ser His Asp Ala Glu 
465                 470                 475                 480 


Ser Phe Gln Met His Ile Thr Gln Glu Gly Ala Gly Asn Ser Arg Val 
                485                 490                 495     


Glu Ile Thr Thr Asn Gln Ser Ile Ile Ile Gly Gly Leu Phe Pro Gly 
            500                 505                 510         


Thr Lys Tyr Cys Phe Glu Ile Val Pro Lys Gly Pro Asn Gly Thr Glu 
        515                 520                 525             


Gly Ala Ser Arg Thr Val Cys Asn Arg Thr Val Pro Ser Ala Val Phe 
    530                 535                 540                 


Asp Ile His Val Val Tyr Val Thr Thr Thr Glu Met Trp Leu Asp Trp 
545                 550                 555                 560 


Lys Ser Pro Asp Gly Ala Ser Glu Tyr Val Tyr His Leu Val Ile Glu 
                565                 570                 575     


Ser Lys His Gly Ser Asn His Thr Ser Thr Tyr Asp Lys Ala Ile Thr 
            580                 585                 590         


Leu Gln Gly Leu Ile Pro Gly Thr Leu Tyr Asn Ile Thr Ile Ser Pro 
        595                 600                 605             


Glu Val Asp His Val Trp Gly Asp Pro Asn Ser Thr Ala Gln Tyr Thr 
    610                 615                 620                 


Arg Pro Ser Asn Val Ser Asn Ile Asp Val Ser Thr Asn Thr Thr Ala 
625                 630                 635                 640 


Ala Thr Leu Ser Trp Gln Asn Phe Asp Asp Ala Ser Pro Thr Tyr Ser 
                645                 650                 655     


Tyr Cys Leu Leu Ile Glu Lys Ala Gly Asn Ser Ser Asn Ala Thr Gln 
            660                 665                 670         


Val Val Thr Asp Ile Gly Ile Thr Asp Ala Thr Val Thr Glu Leu Ile 
        675                 680                 685             


Pro Gly Ser Ser Tyr Thr Val Glu Ile Phe Ala Gln Val Gly Asp Gly 
    690                 695                 700                 


Ile Lys Ser Leu Glu Pro Gly Arg Lys Ser Phe Cys Thr Asp Pro Ala 
705                 710                 715                 720 


Ser Met Ala Ser Phe Asp Cys Glu Val Val Pro Lys Glu Pro Ala Leu 
                725                 730                 735     


Val Leu Lys Trp Thr Cys Pro Pro Gly Ala Asn Ala Gly Phe Glu Leu 
            740                 745                 750         


Glu Val Ser Ser Gly Ala Trp Asn Asn Ala Thr His Leu Glu Ser Cys 
        755                 760                 765             


Ser Ser Glu Asn Gly Thr Glu Tyr Arg Thr Glu Val Thr Tyr Leu Asn 
    770                 775                 780                 


Phe Ser Thr Ser Tyr Asn Ile Ser Ile Thr Thr Val Ser Cys Gly Lys 
785                 790                 795                 800 


Met Ala Ala Pro Thr Arg Asn Thr Cys Thr Thr Gly Ile Thr Asp Pro 
                805                 810                 815     


Pro Pro Pro Asp Gly Ser Pro Asn Ile Thr Ser Val Ser His Asn Ser 
            820                 825                 830         


Val Lys Val Lys Phe Ser Gly Phe Glu Ala Ser His Gly Pro Ile Lys 
        835                 840                 845             


Ala Tyr Ala Val Ile Leu Thr Thr Gly Glu Ala Gly His Pro Ser Ala 
    850                 855                 860                 


Asp Val Leu Lys Tyr Thr Tyr Glu Asp Phe Lys Lys Gly Ala Ser Asp 
865                 870                 875                 880 


Thr Tyr Val Thr Tyr Leu Ile Arg Thr Glu Glu Lys Gly Arg Ser Gln 
                885                 890                 895     


Ser Leu Ser Glu Val Leu Lys Tyr Glu Ile Asp Val Gly Asn Glu Ser 
            900                 905                 910         


Thr Thr Leu Gly Tyr Tyr Asn Gly Lys Leu Glu Pro Leu Gly Ser Tyr 
        915                 920                 925             


Arg Ala Cys Val Ala Gly Phe Thr Asn Ile Thr Phe His Pro Gln Asn 
    930                 935                 940                 


Lys Gly Leu Ile Asp Gly Ala Glu Ser Tyr Val Ser Phe Ser Arg Tyr 
945                 950                 955                 960 


Ser Asp Ala Val Ser Leu Pro Gln Asp Pro Gly Val Ile Cys Gly Ala 
                965                 970                 975     


Val Phe Gly Cys Ile Phe Gly Ala Leu Val Ile Val Thr Val Gly Gly 
            980                 985                 990         


Phe Ile Phe Trp Arg Lys Lys Arg  Lys Asp Ala Lys Asn  Asn Glu Val 
        995                 1000                 1005             


Ser Phe  Ser Gln Ile Lys Ser  Leu Lys Arg Ser Lys  Leu Ile Arg 
    1010                 1015                 1020             


Val Glu  Asn Phe Glu Ala Tyr  Phe Lys Lys Gln Gln  Ala Asp Ser 
    1025                 1030                 1035             


Asn Cys  Gly Phe Ala Glu Glu  Tyr Glu Asp Leu Lys  Leu Val Gly 
    1040                 1045                 1050             


Ile Ser  Gln Pro Lys Tyr Ala  Ala Glu Leu Ala Glu  Asn Arg Gly 
    1055                 1060                 1065             


Lys Asn  Arg Tyr Asn Asn Val  Leu Pro Tyr Asp Ile  Ser Arg Val 
    1070                 1075                 1080             


Lys Leu  Ser Val Gln Thr His  Ser Thr Asp Asp Tyr  Ile Asn Ala 
    1085                 1090                 1095             


Asn Tyr  Met Pro Gly Tyr His  Ser Lys Lys Asp Phe  Ile Ala Thr 
    1100                 1105                 1110             


Gln Gly  Pro Leu Pro Asn Thr  Leu Lys Asp Phe Trp  Arg Met Val 
    1115                 1120                 1125             


Trp Glu  Lys Asn Val Tyr Ala  Ile Ile Met Leu Thr  Lys Cys Val 
    1130                 1135                 1140             


Glu Gln  Gly Arg Thr Lys Cys  Glu Glu Tyr Trp Pro  Ser Lys Gln 
    1145                 1150                 1155             


Ala Gln  Asp Tyr Gly Asp Ile  Thr Val Ala Met Thr  Ser Glu Ile 
    1160                 1165                 1170             


Val Leu  Pro Glu Trp Thr Ile  Arg Asp Phe Thr Val  Lys Asn Ile 
    1175                 1180                 1185             


Gln Thr  Ser Glu Ser His Pro  Leu Arg Gln Phe His  Phe Thr Ser 
    1190                 1195                 1200             


Trp Pro  Asp His Gly Val Pro  Asp Thr Thr Asp Leu  Leu Ile Asn 
    1205                 1210                 1215             


Phe Arg  Tyr Leu Val Arg Asp  Tyr Met Lys Gln Ser  Pro Pro Glu 
    1220                 1225                 1230             


Ser Pro  Ile Leu Val His Cys  Ser Ala Gly Val Gly  Arg Thr Gly 
    1235                 1240                 1245             


Thr Phe  Ile Ala Ile Asp Arg  Leu Ile Tyr Gln Ile  Glu Asn Glu 
    1250                 1255                 1260             


Asn Thr  Val Asp Val Tyr Gly  Ile Val Tyr Asp Leu  Arg Met His 
    1265                 1270                 1275             


Arg Pro  Leu Met Val Gln Thr  Glu Asp Gln Tyr Val  Phe Leu Asn 
    1280                 1285                 1290             


Gln Cys  Val Leu Asp Ile Val  Arg Ser Gln Lys Asp  Ser Lys Val 
    1295                 1300                 1305             


Asp Leu  Ile Tyr Gln Asn Thr  Thr Ala Met Thr Ile  Tyr Glu Asn 
    1310                 1315                 1320             


Leu Ala  Pro Val Thr Thr Phe  Gly Lys Thr Asn Gly  Tyr Ile Ala 
    1325                 1330                 1335             


<210>  400
<211>  1342
<212>  PRT
<213>  Homo sapiens

<400>  400

Met Lys Pro Ala Ala Arg Glu Ala Arg Leu Pro Pro Arg Ser Pro Gly 
1               5                   10                  15      


Leu Arg Trp Ala Leu Pro Leu Leu Leu Leu Leu Leu Arg Leu Gly Gln 
            20                  25                  30          


Ile Leu Cys Ala Gly Gly Thr Pro Ser Pro Ile Pro Asp Pro Ser Val 
        35                  40                  45              


Ala Thr Val Ala Thr Gly Glu Asn Gly Ile Thr Gln Ile Ser Ser Thr 
    50                  55                  60                  


Ala Glu Ser Phe His Lys Gln Asn Gly Thr Gly Thr Pro Gln Val Glu 
65                  70                  75                  80  


Thr Asn Thr Ser Glu Asp Gly Glu Ser Ser Gly Ala Asn Asp Ser Leu 
                85                  90                  95      


Arg Thr Pro Glu Gln Gly Ser Asn Gly Thr Asp Gly Ala Ser Gln Lys 
            100                 105                 110         


Thr Pro Ser Ser Thr Gly Pro Ser Pro Val Phe Asp Ile Lys Ala Val 
        115                 120                 125             


Ser Ile Ser Pro Thr Asn Val Ile Leu Thr Trp Lys Ser Asn Asp Thr 
    130                 135                 140                 


Ala Ala Ser Glu Tyr Lys Tyr Val Val Lys His Lys Met Glu Asn Glu 
145                 150                 155                 160 


Lys Thr Ile Thr Val Val His Gln Pro Trp Cys Asn Ile Thr Gly Leu 
                165                 170                 175     


Arg Pro Ala Thr Ser Tyr Val Phe Ser Ile Thr Pro Gly Ile Gly Asn 
            180                 185                 190         


Glu Thr Trp Gly Asp Pro Arg Val Ile Lys Val Ile Thr Glu Pro Ile 
        195                 200                 205             


Pro Val Ser Asp Leu Arg Val Ala Leu Thr Gly Val Arg Lys Ala Ala 
    210                 215                 220                 


Leu Ser Trp Ser Asn Gly Asn Gly Thr Ala Ser Cys Arg Val Leu Leu 
225                 230                 235                 240 


Glu Ser Ile Gly Ser His Glu Glu Leu Thr Gln Asp Ser Arg Leu Gln 
                245                 250                 255     


Val Asn Ile Ser Gly Leu Lys Pro Gly Val Gln Tyr Asn Ile Asn Pro 
            260                 265                 270         


Tyr Leu Leu Gln Ser Asn Lys Thr Lys Gly Asp Pro Leu Gly Thr Glu 
        275                 280                 285             


Gly Gly Leu Asp Ala Ser Asn Thr Glu Arg Ser Arg Ala Gly Ser Pro 
    290                 295                 300                 


Thr Ala Pro Val His Asp Glu Ser Leu Val Gly Pro Val Asp Pro Ser 
305                 310                 315                 320 


Ser Gly Gln Gln Ser Arg Asp Thr Glu Val Leu Leu Val Gly Leu Glu 
                325                 330                 335     


Pro Gly Thr Arg Tyr Asn Ala Thr Val Tyr Ser Gln Ala Ala Asn Gly 
            340                 345                 350         


Thr Glu Gly Gln Pro Gln Ala Ile Glu Phe Arg Thr Asn Ala Ile Gln 
        355                 360                 365             


Val Phe Asp Val Thr Ala Val Asn Ile Ser Ala Thr Ser Leu Thr Leu 
    370                 375                 380                 


Ile Trp Lys Val Ser Asp Asn Glu Ser Ser Ser Asn Tyr Thr Tyr Lys 
385                 390                 395                 400 


Ile His Val Ala Gly Glu Thr Asp Ser Ser Asn Leu Asn Val Ser Glu 
                405                 410                 415     


Pro Arg Ala Val Ile Pro Gly Leu Arg Ser Ser Thr Phe Tyr Asn Ile 
            420                 425                 430         


Thr Val Cys Pro Val Leu Gly Asp Ile Glu Gly Thr Pro Gly Phe Leu 
        435                 440                 445             


Gln Val His Thr Pro Pro Val Pro Val Ser Asp Phe Arg Val Thr Val 
    450                 455                 460                 


Val Ser Thr Thr Glu Ile Gly Leu Ala Trp Ser Ser His Asp Ala Glu 
465                 470                 475                 480 


Ser Phe Gln Met His Ile Thr Gln Glu Gly Ala Gly Asn Ser Arg Val 
                485                 490                 495     


Glu Ile Thr Thr Asn Gln Ser Ile Ile Ile Gly Gly Leu Phe Pro Gly 
            500                 505                 510         


Thr Lys Tyr Cys Phe Glu Ile Val Pro Lys Gly Pro Asn Gly Thr Glu 
        515                 520                 525             


Gly Ala Ser Arg Thr Val Cys Asn Arg Thr Val Pro Ser Ala Val Phe 
    530                 535                 540                 


Asp Ile His Val Val Tyr Val Thr Thr Thr Glu Met Trp Leu Asp Trp 
545                 550                 555                 560 


Lys Ser Pro Asp Gly Ala Ser Glu Tyr Val Tyr His Leu Val Ile Glu 
                565                 570                 575     


Ser Lys His Gly Ser Asn His Thr Ser Thr Tyr Asp Lys Ala Ile Thr 
            580                 585                 590         


Leu Gln Gly Leu Ile Pro Gly Thr Leu Tyr Asn Ile Thr Ile Ser Pro 
        595                 600                 605             


Glu Val Asp His Val Trp Gly Asp Pro Asn Ser Thr Ala Gln Tyr Thr 
    610                 615                 620                 


Arg Pro Ser Asn Val Ser Asn Ile Asp Val Ser Thr Asn Thr Thr Ala 
625                 630                 635                 640 


Ala Thr Leu Ser Trp Gln Asn Phe Asp Asp Ala Ser Pro Thr Tyr Ser 
                645                 650                 655     


Tyr Cys Leu Leu Ile Glu Lys Ala Gly Asn Ser Ser Asn Ala Thr Gln 
            660                 665                 670         


Val Val Thr Asp Ile Gly Ile Thr Asp Ala Thr Val Thr Glu Leu Ile 
        675                 680                 685             


Pro Gly Ser Ser Tyr Thr Val Glu Ile Phe Ala Gln Val Gly Asp Gly 
    690                 695                 700                 


Ile Lys Ser Leu Glu Pro Gly Arg Lys Ser Phe Cys Thr Asp Pro Ala 
705                 710                 715                 720 


Ser Met Ala Ser Phe Asp Cys Glu Val Val Pro Lys Glu Pro Ala Leu 
                725                 730                 735     


Val Leu Lys Trp Thr Cys Pro Pro Gly Ala Asn Ala Gly Phe Glu Leu 
            740                 745                 750         


Glu Val Ser Ser Gly Ala Trp Asn Asn Ala Thr His Leu Glu Ser Cys 
        755                 760                 765             


Ser Ser Glu Asn Gly Thr Glu Tyr Arg Thr Glu Val Thr Tyr Leu Asn 
    770                 775                 780                 


Phe Ser Thr Ser Tyr Asn Ile Ser Ile Thr Thr Val Ser Cys Gly Lys 
785                 790                 795                 800 


Met Ala Ala Pro Thr Arg Asn Thr Cys Thr Thr Gly Ile Thr Asp Pro 
                805                 810                 815     


Pro Pro Pro Asp Gly Ser Pro Asn Ile Thr Ser Val Ser His Asn Ser 
            820                 825                 830         


Val Lys Val Lys Phe Ser Gly Phe Glu Ala Ser His Gly Pro Ile Lys 
        835                 840                 845             


Ala Tyr Ala Val Ile Leu Thr Thr Gly Glu Ala Gly His Pro Ser Ala 
    850                 855                 860                 


Asp Val Leu Lys Tyr Thr Tyr Glu Asp Phe Lys Lys Gly Ala Ser Asp 
865                 870                 875                 880 


Thr Tyr Val Thr Tyr Leu Ile Arg Thr Glu Glu Lys Gly Arg Ser Gln 
                885                 890                 895     


Ser Leu Ser Glu Val Leu Lys Tyr Glu Ile Asp Val Gly Asn Glu Ser 
            900                 905                 910         


Thr Thr Leu Gly Tyr Tyr Asn Gly Lys Leu Glu Pro Leu Gly Ser Tyr 
        915                 920                 925             


Arg Cys Leu Leu Arg Ala Cys Val Ala Gly Phe Thr Asn Ile Thr Phe 
    930                 935                 940                 


His Pro Gln Asn Lys Gly Leu Ile Asp Gly Ala Glu Ser Tyr Val Ser 
945                 950                 955                 960 


Phe Ser Arg Tyr Ser Asp Ala Val Ser Leu Pro Gln Asp Pro Gly Val 
                965                 970                 975     


Ile Cys Gly Ala Val Phe Gly Cys Ile Phe Gly Ala Leu Val Ile Val 
            980                 985                 990         


Thr Val Gly Gly Phe Ile Phe Trp  Arg Lys Lys Arg Lys  Asp Ala Lys 
        995                 1000                 1005             


Asn Asn  Glu Val Ser Phe Ser  Gln Ile Lys Ser Leu  Lys Arg Ser 
    1010                 1015                 1020             


Lys Leu  Ile Arg Val Glu Asn  Phe Glu Ala Tyr Phe  Lys Lys Gln 
    1025                 1030                 1035             


Gln Ala  Asp Ser Asn Cys Gly  Phe Ala Glu Glu Tyr  Glu Asp Leu 
    1040                 1045                 1050             


Lys Leu  Val Gly Ile Ser Gln  Pro Lys Tyr Ala Ala  Glu Leu Ala 
    1055                 1060                 1065             


Glu Asn  Arg Gly Lys Asn Arg  Tyr Asn Asn Val Leu  Pro Tyr Asp 
    1070                 1075                 1080             


Ile Ser  Arg Val Lys Leu Ser  Val Gln Thr His Ser  Thr Asp Asp 
    1085                 1090                 1095             


Tyr Ile  Asn Ala Asn Tyr Met  Pro Gly Tyr His Ser  Lys Lys Asp 
    1100                 1105                 1110             


Phe Ile  Ala Thr Gln Gly Pro  Leu Pro Asn Thr Leu  Lys Asp Phe 
    1115                 1120                 1125             


Trp Arg  Met Val Trp Glu Lys  Asn Val Tyr Ala Ile  Ile Met Leu 
    1130                 1135                 1140             


Thr Lys  Cys Val Glu Gln Gly  Arg Thr Lys Cys Glu  Glu Tyr Trp 
    1145                 1150                 1155             


Pro Ser  Lys Gln Ala Gln Asp  Tyr Gly Asp Ile Thr  Val Ala Met 
    1160                 1165                 1170             


Thr Ser  Glu Ile Val Leu Pro  Glu Trp Thr Ile Arg  Asp Phe Thr 
    1175                 1180                 1185             


Val Lys  Asn Ile Gln Thr Ser  Glu Ser His Pro Leu  Arg Gln Phe 
    1190                 1195                 1200             


His Phe  Thr Ser Trp Pro Asp  His Gly Val Pro Asp  Thr Thr Asp 
    1205                 1210                 1215             


Leu Leu  Ile Asn Phe Arg Tyr  Leu Val Arg Asp Tyr  Met Lys Gln 
    1220                 1225                 1230             


Ser Pro  Pro Glu Ser Pro Ile  Leu Val His Cys Ser  Ala Gly Val 
    1235                 1240                 1245             


Gly Arg  Thr Gly Thr Phe Ile  Ala Ile Asp Arg Leu  Ile Tyr Gln 
    1250                 1255                 1260             


Ile Glu  Asn Glu Asn Thr Val  Asp Val Tyr Gly Ile  Val Tyr Asp 
    1265                 1270                 1275             


Leu Arg  Met His Arg Pro Leu  Met Val Gln Thr Glu  Asp Gln Tyr 
    1280                 1285                 1290             


Val Phe  Leu Asn Gln Cys Val  Leu Asp Ile Val Arg  Ser Gln Lys 
    1295                 1300                 1305             


Asp Ser  Lys Val Asp Leu Ile  Tyr Gln Asn Thr Thr  Ala Met Thr 
    1310                 1315                 1320             


Ile Tyr  Glu Asn Leu Ala Pro  Val Thr Thr Phe Gly  Lys Thr Asn 
    1325                 1330                 1335             


Gly Tyr  Ile Ala 
    1340         


<210>  401
<211>  858
<212>  PRT
<213>  Homo sapiens

<400>  401

Met Leu Gln Thr Lys Asp Leu Ile Trp Thr Leu Phe Phe Leu Gly Thr 
1               5                   10                  15      


Ala Val Ser Leu Gln Val Asp Ile Val Pro Ser Gln Gly Glu Ile Ser 
            20                  25                  30          


Val Gly Glu Ser Lys Phe Phe Leu Cys Gln Val Ala Gly Asp Ala Lys 
        35                  40                  45              


Asp Lys Asp Ile Ser Trp Phe Ser Pro Asn Gly Glu Lys Leu Thr Pro 
    50                  55                  60                  


Asn Gln Gln Arg Ile Ser Val Val Trp Asn Asp Asp Ser Ser Ser Thr 
65                  70                  75                  80  


Leu Thr Ile Tyr Asn Ala Asn Ile Asp Asp Ala Gly Ile Tyr Lys Cys 
                85                  90                  95      


Val Val Thr Gly Glu Asp Gly Ser Glu Ser Glu Ala Thr Val Asn Val 
            100                 105                 110         


Lys Ile Phe Gln Lys Leu Met Phe Lys Asn Ala Pro Thr Pro Gln Glu 
        115                 120                 125             


Phe Arg Glu Gly Glu Asp Ala Val Ile Val Cys Asp Val Val Ser Ser 
    130                 135                 140                 


Leu Pro Pro Thr Ile Ile Trp Lys His Lys Gly Arg Asp Val Ile Leu 
145                 150                 155                 160 


Lys Lys Asp Val Arg Phe Ile Val Leu Ser Asn Asn Tyr Leu Gln Ile 
                165                 170                 175     


Arg Gly Ile Lys Lys Thr Asp Glu Gly Thr Tyr Arg Cys Glu Gly Arg 
            180                 185                 190         


Ile Leu Ala Arg Gly Glu Ile Asn Phe Lys Asp Ile Gln Val Ile Val 
        195                 200                 205             


Asn Val Pro Pro Thr Ile Gln Ala Arg Gln Asn Ile Val Asn Ala Thr 
    210                 215                 220                 


Ala Asn Leu Gly Gln Ser Val Thr Leu Val Cys Asp Ala Glu Gly Phe 
225                 230                 235                 240 


Pro Glu Pro Thr Met Ser Trp Thr Lys Asp Gly Glu Gln Ile Glu Gln 
                245                 250                 255     


Glu Glu Asp Asp Glu Lys Tyr Ile Phe Ser Asp Asp Ser Ser Gln Leu 
            260                 265                 270         


Thr Ile Lys Lys Val Asp Lys Asn Asp Glu Ala Glu Tyr Ile Cys Ile 
        275                 280                 285             


Ala Glu Asn Lys Ala Gly Glu Gln Asp Ala Thr Ile His Leu Lys Val 
    290                 295                 300                 


Phe Ala Lys Pro Lys Ile Thr Tyr Val Glu Asn Gln Thr Ala Met Glu 
305                 310                 315                 320 


Leu Glu Glu Gln Val Thr Leu Thr Cys Glu Ala Ser Gly Asp Pro Ile 
                325                 330                 335     


Pro Ser Ile Thr Trp Arg Thr Ser Thr Arg Asn Ile Ser Ser Glu Glu 
            340                 345                 350         


Lys Ala Ser Trp Thr Arg Pro Glu Lys Gln Glu Thr Leu Asp Gly His 
        355                 360                 365             


Met Val Val Arg Ser His Ala Arg Val Ser Ser Leu Thr Leu Lys Ser 
    370                 375                 380                 


Ile Gln Tyr Thr Asp Ala Gly Glu Tyr Ile Cys Thr Ala Ser Asn Thr 
385                 390                 395                 400 


Ile Gly Gln Asp Ser Gln Ser Met Tyr Leu Glu Val Gln Tyr Ala Pro 
                405                 410                 415     


Lys Leu Gln Gly Pro Val Ala Val Tyr Thr Trp Glu Gly Asn Gln Val 
            420                 425                 430         


Asn Ile Thr Cys Glu Val Phe Ala Tyr Pro Ser Ala Thr Ile Ser Trp 
        435                 440                 445             


Phe Arg Asp Gly Gln Leu Leu Pro Ser Ser Asn Tyr Ser Asn Ile Lys 
    450                 455                 460                 


Ile Tyr Asn Thr Pro Ser Ala Ser Tyr Leu Glu Val Thr Pro Asp Ser 
465                 470                 475                 480 


Glu Asn Asp Phe Gly Asn Tyr Asn Cys Thr Ala Val Asn Arg Ile Gly 
                485                 490                 495     


Gln Glu Ser Leu Glu Phe Ile Leu Val Gln Ala Asp Thr Pro Ser Ser 
            500                 505                 510         


Pro Ser Ile Asp Gln Val Glu Pro Tyr Ser Ser Thr Ala Gln Val Gln 
        515                 520                 525             


Phe Asp Glu Pro Glu Ala Thr Gly Gly Val Pro Ile Leu Lys Tyr Lys 
    530                 535                 540                 


Ala Glu Trp Arg Ala Val Gly Glu Glu Val Trp His Ser Lys Trp Tyr 
545                 550                 555                 560 


Asp Ala Lys Glu Ala Ser Met Glu Gly Ile Val Thr Ile Val Gly Leu 
                565                 570                 575     


Lys Pro Glu Thr Thr Tyr Ala Val Arg Leu Ala Ala Leu Asn Gly Lys 
            580                 585                 590         


Gly Leu Gly Glu Ile Ser Ala Ala Ser Glu Phe Lys Thr Gln Pro Val 
        595                 600                 605             


Gln Gly Glu Pro Ser Ala Pro Lys Leu Glu Gly Gln Met Gly Glu Asp 
    610                 615                 620                 


Gly Asn Ser Ile Lys Val Asn Leu Ile Lys Gln Asp Asp Gly Gly Ser 
625                 630                 635                 640 


Pro Ile Arg His Tyr Leu Val Arg Tyr Arg Ala Leu Ser Ser Glu Trp 
                645                 650                 655     


Lys Pro Glu Ile Arg Leu Pro Ser Gly Ser Asp His Val Met Leu Lys 
            660                 665                 670         


Ser Leu Asp Trp Asn Ala Glu Tyr Glu Val Tyr Val Val Ala Glu Asn 
        675                 680                 685             


Gln Gln Gly Lys Ser Lys Ala Ala His Phe Val Phe Arg Thr Ser Ala 
    690                 695                 700                 


Gln Pro Thr Ala Ile Pro Ala Asn Gly Ser Pro Thr Ser Gly Leu Ser 
705                 710                 715                 720 


Thr Gly Ala Ile Val Gly Ile Leu Ile Val Ile Phe Val Leu Leu Leu 
                725                 730                 735     


Val Val Val Asp Ile Thr Cys Tyr Phe Leu Asn Lys Cys Gly Leu Phe 
            740                 745                 750         


Met Cys Ile Ala Val Asn Leu Cys Gly Lys Ala Gly Pro Gly Ala Lys 
        755                 760                 765             


Gly Lys Asp Met Glu Glu Gly Lys Ala Ala Phe Ser Lys Asp Glu Ser 
    770                 775                 780                 


Lys Glu Pro Ile Val Glu Val Arg Thr Glu Glu Glu Arg Thr Pro Asn 
785                 790                 795                 800 


His Asp Gly Gly Lys His Thr Glu Pro Asn Glu Thr Thr Pro Leu Thr 
                805                 810                 815     


Glu Pro Glu Lys Gly Pro Val Glu Ala Lys Pro Glu Cys Gln Glu Thr 
            820                 825                 830         


Glu Thr Lys Pro Ala Pro Ala Glu Val Lys Thr Val Pro Asn Asp Ala 
        835                 840                 845             


Thr Gln Thr Lys Glu Asn Glu Ser Lys Ala 
    850                 855             


<210>  402
<211>  725
<212>  PRT
<213>  Homo sapiens

<400>  402

Met Leu Gln Thr Lys Asp Leu Ile Trp Thr Leu Phe Phe Leu Gly Thr 
1               5                   10                  15      


Ala Val Ser Leu Gln Val Asp Ile Val Pro Ser Gln Gly Glu Ile Ser 
            20                  25                  30          


Val Gly Glu Ser Lys Phe Phe Leu Cys Gln Val Ala Gly Asp Ala Lys 
        35                  40                  45              


Asp Lys Asp Ile Ser Trp Phe Ser Pro Asn Gly Glu Lys Leu Thr Pro 
    50                  55                  60                  


Asn Gln Gln Arg Ile Ser Val Val Trp Asn Asp Asp Ser Ser Ser Thr 
65                  70                  75                  80  


Leu Thr Ile Tyr Asn Ala Asn Ile Asp Asp Ala Gly Ile Tyr Lys Cys 
                85                  90                  95      


Val Val Thr Gly Glu Asp Gly Ser Glu Ser Glu Ala Thr Val Asn Val 
            100                 105                 110         


Lys Ile Phe Gln Lys Leu Met Phe Lys Asn Ala Pro Thr Pro Gln Glu 
        115                 120                 125             


Phe Arg Glu Gly Glu Asp Ala Val Ile Val Cys Asp Val Val Ser Ser 
    130                 135                 140                 


Leu Pro Pro Thr Ile Ile Trp Lys His Lys Gly Arg Asp Val Ile Leu 
145                 150                 155                 160 


Lys Lys Asp Val Arg Phe Ile Val Leu Ser Asn Asn Tyr Leu Gln Ile 
                165                 170                 175     


Arg Gly Ile Lys Lys Thr Asp Glu Gly Thr Tyr Arg Cys Glu Gly Arg 
            180                 185                 190         


Ile Leu Ala Arg Gly Glu Ile Asn Phe Lys Asp Ile Gln Val Ile Val 
        195                 200                 205             


Asn Val Pro Pro Thr Ile Gln Ala Arg Gln Asn Ile Val Asn Ala Thr 
    210                 215                 220                 


Ala Asn Leu Gly Gln Ser Val Thr Leu Val Cys Asp Ala Glu Gly Phe 
225                 230                 235                 240 


Pro Glu Pro Thr Met Ser Trp Thr Lys Asp Gly Glu Gln Ile Glu Gln 
                245                 250                 255     


Glu Glu Asp Asp Glu Lys Tyr Ile Phe Ser Asp Asp Ser Ser Gln Leu 
            260                 265                 270         


Thr Ile Lys Lys Val Asp Lys Asn Asp Glu Ala Glu Tyr Ile Cys Ile 
        275                 280                 285             


Ala Glu Asn Lys Ala Gly Glu Gln Asp Ala Thr Ile His Leu Lys Val 
    290                 295                 300                 


Phe Ala Lys Pro Lys Ile Thr Tyr Val Glu Asn Gln Thr Ala Met Glu 
305                 310                 315                 320 


Leu Glu Glu Gln Val Thr Leu Thr Cys Glu Ala Ser Gly Asp Pro Ile 
                325                 330                 335     


Pro Ser Ile Thr Trp Arg Thr Ser Thr Arg Asn Ile Ser Ser Glu Glu 
            340                 345                 350         


Lys Thr Leu Asp Gly His Met Val Val Arg Ser His Ala Arg Val Ser 
        355                 360                 365             


Ser Leu Thr Leu Lys Ser Ile Gln Tyr Thr Asp Ala Gly Glu Tyr Ile 
    370                 375                 380                 


Cys Thr Ala Ser Asn Thr Ile Gly Gln Asp Ser Gln Ser Met Tyr Leu 
385                 390                 395                 400 


Glu Val Gln Tyr Ala Pro Lys Leu Gln Gly Pro Val Ala Val Tyr Thr 
                405                 410                 415     


Trp Glu Gly Asn Gln Val Asn Ile Thr Cys Glu Val Phe Ala Tyr Pro 
            420                 425                 430         


Ser Ala Thr Ile Ser Trp Phe Arg Asp Gly Gln Leu Leu Pro Ser Ser 
        435                 440                 445             


Asn Tyr Ser Asn Ile Lys Ile Tyr Asn Thr Pro Ser Ala Ser Tyr Leu 
    450                 455                 460                 


Glu Val Thr Pro Asp Ser Glu Asn Asp Phe Gly Asn Tyr Asn Cys Thr 
465                 470                 475                 480 


Ala Val Asn Arg Ile Gly Gln Glu Ser Leu Glu Phe Ile Leu Val Gln 
                485                 490                 495     


Ala Asp Thr Pro Ser Ser Pro Ser Ile Asp Gln Val Glu Pro Tyr Ser 
            500                 505                 510         


Ser Thr Ala Gln Val Gln Phe Asp Glu Pro Glu Ala Thr Gly Gly Val 
        515                 520                 525             


Pro Ile Leu Lys Tyr Lys Ala Glu Trp Arg Ala Val Gly Glu Glu Val 
    530                 535                 540                 


Trp His Ser Lys Trp Tyr Asp Ala Lys Glu Ala Ser Met Glu Gly Ile 
545                 550                 555                 560 


Val Thr Ile Val Gly Leu Lys Pro Glu Thr Thr Tyr Ala Val Arg Leu 
                565                 570                 575     


Ala Ala Leu Asn Gly Lys Gly Leu Gly Glu Ile Ser Ala Ala Ser Glu 
            580                 585                 590         


Phe Lys Thr Gln Pro Val Arg Glu Pro Ser Ala Pro Lys Leu Glu Gly 
        595                 600                 605             


Gln Met Gly Glu Asp Gly Asn Ser Ile Lys Val Asn Leu Ile Lys Gln 
    610                 615                 620                 


Asp Asp Gly Gly Ser Pro Ile Arg His Tyr Leu Val Arg Tyr Arg Ala 
625                 630                 635                 640 


Leu Ser Ser Glu Trp Lys Pro Glu Ile Arg Leu Pro Ser Gly Ser Asp 
                645                 650                 655     


His Val Met Leu Lys Ser Leu Asp Trp Asn Ala Glu Tyr Glu Val Tyr 
            660                 665                 670         


Val Val Ala Glu Asn Gln Gln Gly Lys Ser Lys Ala Ala His Phe Val 
        675                 680                 685             


Phe Arg Thr Ser Ala Gln Pro Thr Ala Ile Pro Ala Thr Leu Gly Gly 
    690                 695                 700                 


Asn Ser Ala Ser Tyr Thr Phe Val Ser Leu Leu Phe Ser Ala Val Thr 
705                 710                 715                 720 


Leu Leu Leu Leu Cys 
                725 


<210>  403
<211>  84
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  403

Xaa Gln Asp Asp Gly Gly Ser Pro Ile Arg His Tyr Leu Val Arg Tyr 
1               5                   10                  15      


Arg Ala Leu Ser Ser Glu Trp Lys Pro Glu Ile Arg Leu Pro Ser Gly 
            20                  25                  30          


Ser Asp His Val Met Leu Lys Ser Leu Asp Trp Asn Ala Glu Tyr Glu 
        35                  40                  45              


Val Tyr Val Val Ala Glu Asn Gln Gln Gly Lys Ser Lys Ala Ala His 
    50                  55                  60                  


Phe Val Phe Arg Thr Ser Ala Gln Pro Thr Ala Ile Pro Val Thr Leu 
65                  70                  75                  80  


Leu Leu Leu Cys 
                


<210>  404
<211>  305
<212>  PRT
<213>  Homo sapiens

<400>  404

Tyr Asn Thr Pro Ser Ala Ser Tyr Leu Glu Val Thr Pro Asp Ser Glu 
1               5                   10                  15      


Asn Asp Phe Gly Asn Tyr Asn Cys Thr Ala Val Asn Arg Ile Gly Gln 
            20                  25                  30          


Glu Ser Leu Glu Phe Ile Leu Val Gln Ala Asp Thr Pro Ser Ser Pro 
        35                  40                  45              


Ser Ile Asp Gln Val Glu Pro Tyr Ser Ser Thr Ala Gln Val Gln Phe 
    50                  55                  60                  


Asp Glu Pro Glu Ala Thr Gly Gly Val Pro Ile Leu Lys Tyr Lys Ala 
65                  70                  75                  80  


Glu Trp Arg Ala Val Gly Glu Glu Val Trp His Ser Lys Trp Tyr Asp 
                85                  90                  95      


Ala Lys Glu Ala Ser Met Glu Gly Ile Val Thr Ile Val Gly Leu Lys 
            100                 105                 110         


Pro Glu Thr Thr Tyr Ala Val Arg Leu Ala Ala Leu Asn Gly Lys Gly 
        115                 120                 125             


Leu Gly Glu Ile Ser Ala Ala Ser Glu Phe Lys Thr Gln Pro Val His 
    130                 135                 140                 


Ser Pro Pro Pro Pro Ala Ser Ala Ser Ser Ser Thr Pro Val Pro Leu 
145                 150                 155                 160 


Ser Pro Pro Asp Thr Thr Trp Pro Leu Pro Ala Leu Ala Thr Thr Glu 
                165                 170                 175     


Pro Ala Arg Glu Pro Ser Ala Pro Lys Leu Glu Gly Gln Met Gly Glu 
            180                 185                 190         


Asp Gly Asn Ser Ile Lys Val Asn Leu Ile Lys Gln Asp Asp Gly Gly 
        195                 200                 205             


Ser Pro Ile Arg His Tyr Leu Val Arg Tyr Arg Ala Leu Ser Ser Glu 
    210                 215                 220                 


Trp Lys Pro Glu Ile Arg Leu Pro Ser Gly Ser Asp His Val Met Leu 
225                 230                 235                 240 


Lys Ser Leu Asp Trp Asn Ala Glu Tyr Glu Val Tyr Val Val Ala Glu 
                245                 250                 255     


Asn Gln Gln Gly Lys Ser Lys Ala Ala His Phe Val Phe Arg Thr Ser 
            260                 265                 270         


Ala Gln Pro Thr Ala Ile Pro Ala Thr Leu Gly Gly Asn Ser Ala Ser 
        275                 280                 285             


Tyr Thr Phe Val Ser Leu Leu Phe Ser Ala Val Thr Leu Leu Leu Leu 
    290                 295                 300                 


Cys 
305 


<210>  405
<211>  468
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  405

Xaa Ser Gly Ser Asp His Val Met Leu Lys Ser Leu Asp Trp Asn Ala 
1               5                   10                  15      


Glu Tyr Glu Val Tyr Val Val Ala Glu Asn Gln Gln Gly Lys Ser Lys 
            20                  25                  30          


Ala Ala His Phe Val Phe Arg Thr Ser Ala Gln Pro Thr Ala Ile Pro 
        35                  40                  45              


Ala Asn Gly Ser Pro Thr Ser Gly Leu Ser Thr Gly Ala Ile Val Gly 
    50                  55                  60                  


Ile Leu Ile Val Ile Phe Val Leu Leu Leu Val Val Val Asp Ile Thr 
65                  70                  75                  80  


Cys Tyr Phe Leu Asn Lys Cys Gly Leu Phe Met Cys Ile Ala Val Asn 
                85                  90                  95      


Leu Cys Gly Lys Ala Gly Pro Gly Ala Lys Gly Lys Asp Met Glu Glu 
            100                 105                 110         


Gly Lys Ala Ala Phe Ser Lys Asp Glu Ser Lys Glu Pro Ile Val Glu 
        115                 120                 125             


Val Arg Thr Glu Glu Glu Arg Thr Pro Asn His Asp Gly Gly Lys His 
    130                 135                 140                 


Thr Glu Pro Asn Glu Thr Thr Pro Leu Thr Glu Pro Glu Leu Pro Ala 
145                 150                 155                 160 


Asp Thr Thr Ala Thr Val Glu Asp Met Leu Pro Ser Val Thr Thr Val 
                165                 170                 175     


Thr Thr Asn Ser Asp Thr Ile Thr Glu Thr Phe Ala Thr Ala Gln Asn 
            180                 185                 190         


Ser Pro Thr Ser Glu Thr Thr Thr Leu Thr Ser Ser Ile Ala Pro Pro 
        195                 200                 205             


Ala Thr Ala Thr Pro Asp Ser Asn Ser Val Pro Ala Gly Gln Ala Thr 
    210                 215                 220                 


Pro Ser Lys Gly Pro Ser Ala Ser Ala Pro Ser Pro Ala Pro Ala Ser 
225                 230                 235                 240 


Ala Pro Lys Val Ala Pro Leu Val Asp Leu Ser Asp Thr Pro Thr Ser 
                245                 250                 255     


Thr Pro Ala Ala Ser Asn Leu Ser Ser Ser Val Leu Ala Asn Gln Gly 
            260                 265                 270         


Ala Val Leu Ser Pro Ser Ala Pro Ala Gly Val Gly Glu Ala Ser Lys 
        275                 280                 285             


Ala Pro Pro Ala Ser Lys Pro Thr Pro Ala Pro Val Pro Thr Pro Thr 
    290                 295                 300                 


Gly Ala Ala Ser Pro Leu Ala Ala Ala Ala Ala Pro Ala Thr Glu Ala 
305                 310                 315                 320 


Pro Gln Ala Lys Gln Glu Ala Pro Ser Thr Lys Gly Pro Asp Pro Glu 
                325                 330                 335     


Pro Thr Gln Pro Gly Ala Ala Lys Ser Pro Ala Glu Ala Ala Thr Ala 
            340                 345                 350         


Leu Ala Ser Pro Lys Ser Glu Ala Ala Ser Val Ser Thr Thr Asn Pro 
        355                 360                 365             


Ser Gln Gly Glu Asp Phe Lys Met Asp Glu Gly Asn Phe Lys Thr Pro 
    370                 375                 380                 


Asp Ile Asp Leu Ala Lys Asp Val Phe Ala Ala Leu Gly Ser Pro Ala 
385                 390                 395                 400 


Pro Ala Ala Gly Ala Ser Gly Gln Ala Pro Glu Leu Ala Pro Ser Thr 
                405                 410                 415     


Ala Asp Ser Ser Val Ser Pro Ala Pro Ala Lys Thr Glu Lys Gly Pro 
            420                 425                 430         


Val Glu Ala Lys Pro Glu Cys Gln Glu Thr Glu Thr Lys Pro Ala Pro 
        435                 440                 445             


Ala Glu Val Lys Thr Val Pro Asn Asp Ala Thr Gln Thr Lys Glu Asn 
    450                 455                 460                 


Glu Ser Lys Ala 
465             


<210>  406
<211>  372
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  406

Xaa Thr Pro Ser Ser Pro Ser Ile Asp Gln Val Glu Pro Tyr Ser Ser 
1               5                   10                  15      


Thr Ala Gln Val Gln Phe Asp Glu Pro Glu Ala Thr Gly Gly Val Pro 
            20                  25                  30          


Ile Leu Lys Tyr Lys Ala Glu Trp Arg Ala Val Gly Glu Glu Val Trp 
        35                  40                  45              


His Ser Lys Trp Tyr Asp Ala Lys Glu Ala Ser Met Glu Gly Ile Val 
    50                  55                  60                  


Thr Ile Val Gly Leu Lys Pro Glu Thr Thr Tyr Ala Val Arg Leu Ala 
65                  70                  75                  80  


Ala Leu Asn Gly Lys Gly Leu Gly Glu Ile Ser Ala Ala Ser Glu Phe 
                85                  90                  95      


Lys Thr Gln Pro Val His Ser Pro Pro Pro Pro Ala Ser Ala Ser Ser 
            100                 105                 110         


Ser Thr Pro Val Pro Leu Ser Pro Pro Asp Lys Gly Glu Pro Ser Ala 
        115                 120                 125             


Pro Lys Leu Glu Gly Gln Met Gly Glu Asp Gly Asn Ser Ile Lys Val 
    130                 135                 140                 


Asn Leu Ile Lys Gln Asp Asp Gly Gly Ser Pro Ile Arg His Tyr Leu 
145                 150                 155                 160 


Val Arg Tyr Arg Ala Leu Ser Ser Glu Trp Lys Pro Glu Ile Arg Leu 
                165                 170                 175     


Pro Ser Gly Ser Asp His Val Met Leu Lys Ser Leu Asp Trp Asn Ala 
            180                 185                 190         


Glu Tyr Glu Val Tyr Val Val Ala Glu Asn Gln Gln Gly Lys Ser Lys 
        195                 200                 205             


Ala Ala His Phe Val Phe Arg Thr Ser Ala Gln Pro Thr Ala Ile Pro 
    210                 215                 220                 


Ala Asn Gly Ser Pro Thr Ser Gly Leu Ser Thr Gly Ala Ile Val Gly 
225                 230                 235                 240 


Ile Leu Ile Val Ile Phe Val Leu Leu Leu Val Val Val Asp Ile Thr 
                245                 250                 255     


Cys Tyr Phe Leu Asn Lys Cys Gly Leu Phe Met Cys Ile Ala Val Asn 
            260                 265                 270         


Leu Cys Gly Lys Ala Gly Pro Gly Ala Lys Gly Lys Asp Met Glu Glu 
        275                 280                 285             


Gly Lys Ala Ala Phe Ser Lys Asp Glu Ser Lys Glu Pro Ile Val Glu 
    290                 295                 300                 


Val Arg Thr Glu Glu Glu Arg Thr Pro Asn His Asp Gly Gly Lys His 
305                 310                 315                 320 


Thr Glu Pro Asn Glu Thr Thr Pro Leu Thr Glu Pro Glu Lys Gly Pro 
                325                 330                 335     


Val Glu Ala Lys Pro Glu Cys Gln Glu Thr Glu Thr Lys Pro Ala Pro 
            340                 345                 350         


Ala Glu Val Lys Thr Val Pro Asn Asp Ala Thr Gln Thr Lys Glu Asn 
        355                 360                 365             


Glu Ser Lys Ala 
    370         


<210>  407
<211>  364
<212>  PRT
<213>  Homo sapiens

<400>  407

Met Leu Gln Thr Lys Asp Leu Ile Trp Thr Leu Phe Phe Leu Gly Thr 
1               5                   10                  15      


Ala Val Ser Leu Gln Val Asp Ile Val Pro Ser Gln Gly Glu Ile Ser 
            20                  25                  30          


Val Gly Glu Ser Lys Phe Phe Leu Cys Gln Val Ala Gly Asp Ala Lys 
        35                  40                  45              


Asp Lys Asp Ile Ser Trp Phe Ser Pro Asn Gly Glu Lys Leu Thr Pro 
    50                  55                  60                  


Asn Gln Gln Arg Ile Ser Val Val Trp Asn Asp Asp Ser Ser Ser Thr 
65                  70                  75                  80  


Leu Thr Ile Tyr Asn Ala Asn Ile Asp Asp Ala Gly Ile Tyr Lys Cys 
                85                  90                  95      


Val Val Thr Gly Glu Asp Gly Ser Glu Ser Glu Ala Thr Val Asn Val 
            100                 105                 110         


Lys Ile Phe Gln Lys Leu Met Phe Lys Asn Ala Pro Thr Pro Gln Glu 
        115                 120                 125             


Phe Arg Glu Gly Glu Asp Ala Val Ile Val Cys Asp Val Val Ser Ser 
    130                 135                 140                 


Leu Pro Pro Thr Ile Ile Trp Lys His Lys Gly Arg Asp Val Ile Leu 
145                 150                 155                 160 


Lys Lys Asp Val Arg Phe Ile Val Leu Ser Asn Asn Tyr Leu Gln Ile 
                165                 170                 175     


Arg Gly Ile Lys Lys Thr Asp Glu Gly Thr Tyr Arg Cys Glu Gly Arg 
            180                 185                 190         


Ile Leu Ala Arg Gly Glu Ile Asn Phe Lys Asp Ile Gln Val Ile Val 
        195                 200                 205             


Asn Val Pro Pro Thr Ile Gln Ala Arg Gln Asn Ile Val Asn Ala Thr 
    210                 215                 220                 


Ala Asn Leu Gly Gln Ser Val Thr Leu Val Cys Asp Ala Glu Gly Phe 
225                 230                 235                 240 


Pro Glu Pro Thr Met Ser Trp Thr Lys Asp Gly Glu Gln Ile Glu Gln 
                245                 250                 255     


Glu Glu Asp Asp Glu Lys Tyr Ile Phe Ser Asp Asp Ser Ser Gln Leu 
            260                 265                 270         


Thr Ile Lys Lys Val Asp Lys Asn Asp Glu Ala Glu Tyr Ile Cys Ile 
        275                 280                 285             


Ala Glu Asn Lys Ala Gly Glu Gln Asp Ala Thr Ile His Leu Lys Val 
    290                 295                 300                 


Phe Ala Lys Pro Lys Ile Thr Tyr Val Glu Asn Gln Thr Ala Met Glu 
305                 310                 315                 320 


Leu Glu Glu Gln Val Thr Leu Thr Cys Glu Ala Ser Gly Asp Pro Ile 
                325                 330                 335     


Pro Ser Ile Thr Trp Arg Thr Ser Thr Arg Asn Ile Ser Ser Glu Glu 
            340                 345                 350         


Lys Ala Ser Trp Thr Arg Pro Glu Lys Gln Glu Val 
        355                 360                 


<210>  408
<211>  848
<212>  PRT
<213>  Homo sapiens

<400>  408

Met Leu Gln Thr Lys Asp Leu Ile Trp Thr Leu Phe Phe Leu Gly Thr 
1               5                   10                  15      


Ala Val Ser Leu Gln Val Asp Ile Val Pro Ser Gln Gly Glu Ile Ser 
            20                  25                  30          


Val Gly Glu Ser Lys Phe Phe Leu Cys Gln Val Ala Gly Asp Ala Lys 
        35                  40                  45              


Asp Lys Asp Ile Ser Trp Phe Ser Pro Asn Gly Glu Lys Leu Thr Pro 
    50                  55                  60                  


Asn Gln Gln Arg Ile Ser Val Val Trp Asn Asp Asp Ser Ser Ser Thr 
65                  70                  75                  80  


Leu Thr Ile Tyr Asn Ala Asn Ile Asp Asp Ala Gly Ile Tyr Lys Cys 
                85                  90                  95      


Val Val Thr Gly Glu Asp Gly Ser Glu Ser Glu Ala Thr Val Asn Val 
            100                 105                 110         


Lys Ile Phe Gln Lys Leu Met Phe Lys Asn Ala Pro Thr Pro Gln Glu 
        115                 120                 125             


Phe Arg Glu Gly Glu Asp Ala Val Ile Val Cys Asp Val Val Ser Ser 
    130                 135                 140                 


Leu Pro Pro Thr Ile Ile Trp Lys His Lys Gly Arg Asp Val Ile Leu 
145                 150                 155                 160 


Lys Lys Asp Val Arg Phe Ile Val Leu Ser Asn Asn Tyr Leu Gln Ile 
                165                 170                 175     


Arg Gly Ile Lys Lys Thr Asp Glu Gly Thr Tyr Arg Cys Glu Gly Arg 
            180                 185                 190         


Ile Leu Ala Arg Gly Glu Ile Asn Phe Lys Asp Ile Gln Val Ile Val 
        195                 200                 205             


Asn Val Pro Pro Thr Ile Gln Ala Arg Gln Asn Ile Val Asn Ala Thr 
    210                 215                 220                 


Ala Asn Leu Gly Gln Ser Val Thr Leu Val Cys Asp Ala Glu Gly Phe 
225                 230                 235                 240 


Pro Glu Pro Thr Met Ser Trp Thr Lys Asp Gly Glu Gln Ile Glu Gln 
                245                 250                 255     


Glu Glu Asp Asp Glu Lys Tyr Ile Phe Ser Asp Asp Ser Ser Gln Leu 
            260                 265                 270         


Thr Ile Lys Lys Val Asp Lys Asn Asp Glu Ala Glu Tyr Ile Cys Ile 
        275                 280                 285             


Ala Glu Asn Lys Ala Gly Glu Gln Asp Ala Thr Ile His Leu Lys Val 
    290                 295                 300                 


Phe Ala Lys Pro Lys Ile Thr Tyr Val Glu Asn Gln Thr Ala Met Glu 
305                 310                 315                 320 


Leu Glu Glu Gln Val Thr Leu Thr Cys Glu Ala Ser Gly Asp Pro Ile 
                325                 330                 335     


Pro Ser Ile Thr Trp Arg Thr Ser Thr Arg Asn Ile Ser Ser Glu Glu 
            340                 345                 350         


Lys Thr Leu Asp Gly His Met Val Val Arg Ser His Ala Arg Val Ser 
        355                 360                 365             


Ser Leu Thr Leu Lys Ser Ile Gln Tyr Thr Asp Ala Gly Glu Tyr Ile 
    370                 375                 380                 


Cys Thr Ala Ser Asn Thr Ile Gly Gln Asp Ser Gln Ser Met Tyr Leu 
385                 390                 395                 400 


Glu Val Gln Tyr Ala Pro Lys Leu Gln Gly Pro Val Ala Val Tyr Thr 
                405                 410                 415     


Trp Glu Gly Asn Gln Val Asn Ile Thr Cys Glu Val Phe Ala Tyr Pro 
            420                 425                 430         


Ser Ala Thr Ile Ser Trp Phe Arg Asp Gly Gln Leu Leu Pro Ser Ser 
        435                 440                 445             


Asn Tyr Ser Asn Ile Lys Ile Tyr Asn Thr Pro Ser Ala Ser Tyr Leu 
    450                 455                 460                 


Glu Val Thr Pro Asp Ser Glu Asn Asp Phe Gly Asn Tyr Asn Cys Thr 
465                 470                 475                 480 


Ala Val Asn Arg Ile Gly Gln Glu Ser Leu Glu Phe Ile Leu Val Gln 
                485                 490                 495     


Ala Asp Thr Pro Ser Ser Pro Ser Ile Asp Gln Val Glu Pro Tyr Ser 
            500                 505                 510         


Ser Thr Ala Gln Val Gln Phe Asp Glu Pro Glu Ala Thr Gly Gly Val 
        515                 520                 525             


Pro Ile Leu Lys Tyr Lys Ala Glu Trp Arg Ala Val Gly Glu Glu Val 
    530                 535                 540                 


Trp His Ser Lys Trp Tyr Asp Ala Lys Glu Ala Ser Met Glu Gly Ile 
545                 550                 555                 560 


Val Thr Ile Val Gly Leu Lys Pro Glu Thr Thr Tyr Ala Val Arg Leu 
                565                 570                 575     


Ala Ala Leu Asn Gly Lys Gly Leu Gly Glu Ile Ser Ala Ala Ser Glu 
            580                 585                 590         


Phe Lys Thr Gln Pro Val Gln Gly Glu Pro Ser Ala Pro Lys Leu Glu 
        595                 600                 605             


Gly Gln Met Gly Glu Asp Gly Asn Ser Ile Lys Val Asn Leu Ile Lys 
    610                 615                 620                 


Gln Asp Asp Gly Gly Ser Pro Ile Arg His Tyr Leu Val Arg Tyr Arg 
625                 630                 635                 640 


Ala Leu Ser Ser Glu Trp Lys Pro Glu Ile Arg Leu Pro Ser Gly Ser 
                645                 650                 655     


Asp His Val Met Leu Lys Ser Leu Asp Trp Asn Ala Glu Tyr Glu Val 
            660                 665                 670         


Tyr Val Val Ala Glu Asn Gln Gln Gly Lys Ser Lys Ala Ala His Phe 
        675                 680                 685             


Val Phe Arg Thr Ser Ala Gln Pro Thr Ala Ile Pro Ala Asn Gly Ser 
    690                 695                 700                 


Pro Thr Ser Gly Leu Ser Thr Gly Ala Ile Val Gly Ile Leu Ile Val 
705                 710                 715                 720 


Ile Phe Val Leu Leu Leu Val Val Val Asp Ile Thr Cys Tyr Phe Leu 
                725                 730                 735     


Asn Lys Cys Gly Leu Phe Met Cys Ile Ala Val Asn Leu Cys Gly Lys 
            740                 745                 750         


Ala Gly Pro Gly Ala Lys Gly Lys Asp Met Glu Glu Gly Lys Ala Ala 
        755                 760                 765             


Phe Ser Lys Asp Glu Ser Lys Glu Pro Ile Val Glu Val Arg Thr Glu 
    770                 775                 780                 


Glu Glu Arg Thr Pro Asn His Asp Gly Gly Lys His Thr Glu Pro Asn 
785                 790                 795                 800 


Glu Thr Thr Pro Leu Thr Glu Pro Glu Lys Gly Pro Val Glu Ala Lys 
                805                 810                 815     


Pro Glu Cys Gln Glu Thr Glu Thr Lys Pro Ala Pro Ala Glu Val Lys 
            820                 825                 830         


Thr Val Pro Asn Asp Ala Thr Gln Thr Lys Glu Asn Glu Ser Lys Ala 
        835                 840                 845             


<210>  409
<211>  165
<212>  PRT
<213>  Homo sapiens

<400>  409

Glu Phe Ile Leu Val Gln Ala Asp Thr Pro Ser Ser Pro Ser Ile Asp 
1               5                   10                  15      


Gln Val Glu Pro Tyr Ser Ser Thr Ala Gln Val Gln Phe Asp Glu Pro 
            20                  25                  30          


Glu Ala Thr Gly Gly Val Pro Ile Leu Lys Tyr Lys Ala Glu Trp Arg 
        35                  40                  45              


Ala Val Gly Glu Glu Val Trp His Ser Lys Trp Tyr Asp Ala Lys Glu 
    50                  55                  60                  


Ala Ser Met Glu Gly Ile Val Thr Ile Val Gly Leu Lys Pro Glu Thr 
65                  70                  75                  80  


Thr Tyr Ala Val Arg Leu Ala Ala Leu Asn Gly Lys Gly Leu Gly Glu 
                85                  90                  95      


Ile Ser Ala Ala Ser Glu Phe Lys Thr Gln Pro Val His Ser Pro Pro 
            100                 105                 110         


Pro Pro Ala Ser Ala Ser Ser Ser Thr Pro Val Pro Leu Ser Pro Pro 
        115                 120                 125             


Asp Thr Thr Trp Pro Leu Pro Ala Leu Ala Thr Thr Glu Pro Ala Lys 
    130                 135                 140                 


Asn Ile Ala Gln Asn His Cys Cys Asn Met Phe Gln Ala Gly Leu His 
145                 150                 155                 160 


Asn Ala Leu Met Lys 
                165 


<210>  410
<211>  357
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  410

Xaa Phe Ile Leu Val Gln Ala Asp Thr Pro Ser Ser Pro Ser Ile Asp 
1               5                   10                  15      


Gln Val Glu Pro Tyr Ser Ser Thr Ala Gln Val Gln Phe Asp Glu Pro 
            20                  25                  30          


Glu Ala Thr Gly Gly Val Pro Ile Leu Lys Tyr Lys Ala Glu Trp Arg 
        35                  40                  45              


Ala Val Gly Glu Glu Val Trp His Ser Lys Trp Tyr Asp Ala Lys Glu 
    50                  55                  60                  


Ala Ser Met Glu Gly Ile Val Thr Ile Val Gly Leu Lys Pro Glu Thr 
65                  70                  75                  80  


Thr Tyr Ala Val Arg Leu Ala Ala Leu Asn Gly Lys Gly Leu Gly Glu 
                85                  90                  95      


Ile Ser Ala Ala Ser Glu Phe Lys Thr Gln Pro Val Arg Glu Pro Ser 
            100                 105                 110         


Ala Pro Lys Leu Glu Gly Gln Met Gly Glu Asp Gly Asn Ser Ile Lys 
        115                 120                 125             


Val Asn Leu Ile Lys Gln Asp Asp Gly Gly Ser Pro Ile Arg His Tyr 
    130                 135                 140                 


Leu Val Arg Tyr Arg Ala Leu Ser Ser Glu Trp Lys Pro Glu Ile Arg 
145                 150                 155                 160 


Leu Pro Ser Gly Ser Asp His Val Met Leu Lys Ser Leu Asp Trp Asn 
                165                 170                 175     


Ala Glu Tyr Glu Val Tyr Val Val Ala Glu Asn Gln Gln Gly Lys Ser 
            180                 185                 190         


Lys Ala Ala His Phe Val Phe Arg Thr Ser Ala Gln Pro Thr Ala Ile 
        195                 200                 205             


Pro Ala Asn Gly Ser Pro Thr Ser Gly Leu Ser Thr Gly Ala Ile Val 
    210                 215                 220                 


Gly Ile Leu Ile Val Ile Phe Val Leu Leu Leu Val Val Val Asp Ile 
225                 230                 235                 240 


Thr Cys Tyr Phe Leu Asn Lys Cys Gly Leu Phe Met Cys Ile Ala Val 
                245                 250                 255     


Asn Leu Cys Gly Lys Ala Gly Pro Gly Ala Lys Gly Lys Asp Met Glu 
            260                 265                 270         


Glu Gly Lys Ala Ala Phe Ser Lys Asp Glu Ser Lys Glu Pro Ile Val 
        275                 280                 285             


Glu Val Arg Thr Glu Glu Glu Arg Thr Pro Asn His Asp Gly Gly Lys 
    290                 295                 300                 


His Thr Glu Pro Asn Glu Thr Thr Pro Leu Thr Glu Pro Glu Lys Gly 
305                 310                 315                 320 


Pro Val Glu Ala Lys Pro Glu Cys Gln Glu Thr Glu Thr Lys Pro Ala 
                325                 330                 335     


Pro Ala Glu Val Lys Thr Val Pro Asn Asp Ala Thr Gln Thr Lys Glu 
            340                 345                 350         


Asn Glu Ser Lys Ala 
        355         


<210>  411
<211>  133
<212>  PRT
<213>  Homo sapiens

<400>  411

Met Leu Gln Thr Lys Asp Leu Ile Trp Thr Leu Phe Phe Leu Gly Thr 
1               5                   10                  15      


Ala Ala Lys Pro Lys Ile Thr Tyr Val Glu Asn Gln Thr Ala Met Glu 
            20                  25                  30          


Leu Glu Glu Gln Val Thr Leu Thr Cys Glu Ala Ser Gly Asp Pro Ile 
        35                  40                  45              


Pro Ser Ile Thr Trp Arg Thr Ser Thr Arg Asn Ile Ser Ser Glu Glu 
    50                  55                  60                  


Lys Thr Leu Asp Gly His Met Val Val Arg Ser His Ala Arg Val Ser 
65                  70                  75                  80  


Ser Leu Thr Leu Lys Ser Ile Gln Tyr Thr Asp Ala Gly Glu Tyr Ile 
                85                  90                  95      


Cys Thr Ala Ser Asn Thr Ile Gly Gln Asp Ser Gln Ser Met Tyr Leu 
            100                 105                 110         


Glu Val Gln Tyr Ala Pro Lys Leu Gln Gly Pro Val Ala Val Tyr Thr 
        115                 120                 125             


Trp Glu Gly Asn Gln 
    130             


<210>  412
<211>  858
<212>  PRT
<213>  Homo sapiens

<400>  412

Met Leu Gln Thr Lys Asp Leu Ile Trp Thr Leu Phe Phe Leu Gly Thr 
1               5                   10                  15      


Ala Val Ser Leu Gln Val Asp Ile Val Pro Ser Gln Gly Glu Ile Ser 
            20                  25                  30          


Val Gly Glu Ser Lys Phe Phe Leu Cys Gln Val Ala Gly Asp Ala Lys 
        35                  40                  45              


Asp Lys Asp Ile Ser Trp Phe Ser Pro Asn Gly Glu Lys Leu Thr Pro 
    50                  55                  60                  


Asn Gln Gln Arg Ile Ser Val Val Trp Asn Asp Asp Ser Ser Ser Thr 
65                  70                  75                  80  


Leu Thr Ile Tyr Asn Ala Asn Ile Asp Asp Ala Gly Ile Tyr Lys Cys 
                85                  90                  95      


Val Val Thr Gly Glu Asp Gly Ser Glu Ser Glu Ala Thr Val Asn Val 
            100                 105                 110         


Lys Ile Phe Gln Lys Leu Met Phe Lys Asn Ala Pro Thr Pro Gln Glu 
        115                 120                 125             


Phe Arg Glu Gly Glu Asp Ala Val Ile Val Cys Asp Val Val Ser Ser 
    130                 135                 140                 


Leu Pro Pro Thr Ile Ile Trp Lys His Lys Gly Arg Asp Val Ile Leu 
145                 150                 155                 160 


Lys Lys Asp Val Arg Phe Ile Val Leu Ser Asn Asn Tyr Leu Gln Ile 
                165                 170                 175     


Arg Gly Ile Lys Lys Thr Asp Glu Gly Thr Tyr Arg Cys Glu Gly Arg 
            180                 185                 190         


Ile Leu Ala Arg Gly Glu Ile Asn Phe Lys Asp Ile Gln Val Ile Val 
        195                 200                 205             


Asn Val Pro Pro Thr Ile Gln Ala Arg Gln Asn Ile Val Asn Ala Thr 
    210                 215                 220                 


Ala Asn Leu Gly Gln Ser Val Thr Leu Val Cys Asp Ala Glu Gly Phe 
225                 230                 235                 240 


Pro Glu Pro Thr Met Ser Trp Thr Lys Asp Gly Glu Gln Ile Glu Gln 
                245                 250                 255     


Glu Glu Asp Asp Glu Lys Tyr Ile Phe Ser Asp Asp Ser Ser Gln Leu 
            260                 265                 270         


Thr Ile Lys Lys Val Asp Lys Asn Asp Glu Ala Glu Tyr Ile Cys Ile 
        275                 280                 285             


Ala Glu Asn Lys Ala Gly Glu Gln Asp Ala Thr Ile His Leu Lys Val 
    290                 295                 300                 


Phe Ala Lys Pro Lys Ile Thr Tyr Val Glu Asn Gln Thr Ala Met Glu 
305                 310                 315                 320 


Leu Glu Glu Gln Val Thr Leu Thr Cys Glu Ala Ser Gly Asp Pro Ile 
                325                 330                 335     


Pro Ser Ile Thr Trp Arg Thr Ser Thr Arg Asn Ile Ser Ser Glu Glu 
            340                 345                 350         


Lys Ala Ser Trp Thr Arg Pro Glu Lys Gln Glu Thr Leu Asp Gly His 
        355                 360                 365             


Met Val Val Arg Ser His Ala Arg Val Ser Ser Leu Thr Leu Lys Ser 
    370                 375                 380                 


Ile Gln Tyr Thr Asp Ala Gly Glu Tyr Ile Cys Thr Ala Ser Asn Thr 
385                 390                 395                 400 


Ile Gly Gln Asp Ser Gln Ser Met Tyr Leu Glu Val Gln Tyr Ala Pro 
                405                 410                 415     


Lys Leu Gln Gly Pro Val Ala Val Tyr Thr Trp Glu Gly Asn Gln Val 
            420                 425                 430         


Asn Ile Thr Cys Glu Val Phe Ala Tyr Pro Ser Ala Thr Ile Ser Trp 
        435                 440                 445             


Phe Arg Asp Gly Gln Leu Leu Pro Ser Ser Asn Tyr Ser Asn Ile Lys 
    450                 455                 460                 


Ile Tyr Asn Thr Pro Ser Ala Ser Tyr Leu Glu Val Thr Pro Asp Ser 
465                 470                 475                 480 


Glu Asn Asp Phe Gly Asn Tyr Asn Cys Thr Ala Val Asn Arg Ile Gly 
                485                 490                 495     


Gln Glu Ser Leu Glu Phe Ile Leu Val Gln Ala Asp Thr Pro Ser Ser 
            500                 505                 510         


Pro Ser Ile Asp Gln Val Glu Pro Tyr Ser Ser Thr Ala Gln Val Gln 
        515                 520                 525             


Phe Asp Glu Pro Glu Ala Thr Gly Gly Val Pro Ile Leu Lys Tyr Lys 
    530                 535                 540                 


Ala Glu Trp Arg Ala Val Gly Glu Glu Val Trp His Ser Lys Trp Tyr 
545                 550                 555                 560 


Asp Ala Lys Glu Ala Ser Met Glu Gly Ile Val Thr Ile Val Gly Leu 
                565                 570                 575     


Lys Pro Glu Thr Thr Tyr Ala Val Arg Leu Ala Ala Leu Asn Gly Lys 
            580                 585                 590         


Gly Leu Gly Glu Ile Ser Ala Ala Ser Glu Phe Lys Thr Gln Pro Val 
        595                 600                 605             


Pro Gly Glu Pro Ser Ala Pro Lys Leu Glu Gly Gln Met Gly Glu Asp 
    610                 615                 620                 


Gly Asn Ser Ile Lys Val Asn Leu Ile Lys Gln Asp Asp Gly Gly Ser 
625                 630                 635                 640 


Pro Ile Arg His Tyr Leu Val Arg Tyr Arg Ala Leu Ser Ser Glu Trp 
                645                 650                 655     


Lys Pro Glu Ile Arg Leu Pro Ser Gly Ser Asp His Val Met Leu Lys 
            660                 665                 670         


Ser Leu Asp Trp Asn Ala Glu Tyr Glu Val Tyr Val Val Ala Glu Asn 
        675                 680                 685             


Gln Gln Gly Lys Ser Lys Ala Ala His Phe Val Phe Arg Thr Ser Ala 
    690                 695                 700                 


Gln Pro Thr Ala Ile Pro Ala Asn Gly Ser Pro Thr Ser Gly Leu Ser 
705                 710                 715                 720 


Thr Gly Ala Ile Val Gly Ile Leu Ile Val Ile Phe Val Leu Leu Leu 
                725                 730                 735     


Val Val Val Asp Ile Thr Cys Tyr Phe Leu Asn Lys Cys Gly Leu Phe 
            740                 745                 750         


Met Cys Ile Ala Val Asn Leu Cys Gly Lys Ala Gly Pro Gly Ala Lys 
        755                 760                 765             


Gly Lys Asp Met Glu Glu Gly Lys Ala Ala Phe Ser Lys Asp Glu Ser 
    770                 775                 780                 


Lys Glu Pro Ile Val Glu Val Arg Thr Glu Glu Glu Arg Thr Pro Asn 
785                 790                 795                 800 


His Asp Gly Gly Lys His Thr Glu Pro Asn Glu Thr Thr Pro Leu Thr 
                805                 810                 815     


Glu Pro Glu Lys Gly Pro Val Glu Ala Lys Pro Glu Cys Gln Glu Thr 
            820                 825                 830         


Glu Thr Lys Pro Ala Pro Ala Glu Val Lys Thr Val Pro Asn Asp Ala 
        835                 840                 845             


Thr Gln Thr Lys Glu Asn Glu Ser Lys Ala 
    850                 855             


<210>  413
<211>  884
<212>  PRT
<213>  Homo sapiens

<400>  413

Met Leu Gln Thr Lys Asp Leu Ile Trp Thr Leu Phe Phe Leu Gly Thr 
1               5                   10                  15      


Ala Val Ser Leu Gln Val Asp Ile Val Pro Ser Gln Gly Glu Ile Ser 
            20                  25                  30          


Val Gly Glu Ser Lys Phe Phe Leu Cys Gln Val Ala Gly Asp Ala Lys 
        35                  40                  45              


Asp Lys Asp Ile Ser Trp Phe Ser Pro Asn Gly Glu Lys Leu Thr Pro 
    50                  55                  60                  


Asn Gln Gln Arg Ile Ser Val Val Trp Asn Asp Asp Ser Ser Ser Thr 
65                  70                  75                  80  


Leu Thr Ile Tyr Asn Ala Asn Ile Asp Asp Ala Gly Ile Tyr Lys Cys 
                85                  90                  95      


Val Val Thr Gly Glu Asp Gly Ser Glu Ser Glu Ala Thr Val Asn Val 
            100                 105                 110         


Lys Ile Phe Gln Lys Leu Met Phe Lys Asn Ala Pro Thr Pro Gln Glu 
        115                 120                 125             


Phe Arg Glu Gly Glu Asp Ala Val Ile Val Cys Asp Val Val Ser Ser 
    130                 135                 140                 


Leu Pro Pro Thr Ile Ile Trp Lys His Lys Gly Arg Asp Val Ile Leu 
145                 150                 155                 160 


Lys Lys Asp Val Arg Phe Ile Val Leu Ser Asn Asn Tyr Leu Gln Ile 
                165                 170                 175     


Arg Gly Ile Lys Lys Thr Asp Glu Gly Thr Tyr Arg Cys Glu Gly Arg 
            180                 185                 190         


Ile Leu Ala Arg Gly Glu Ile Asn Phe Lys Asp Ile Gln Val Ile Val 
        195                 200                 205             


Asn Val Pro Pro Thr Ile Gln Ala Arg Gln Asn Ile Val Asn Ala Thr 
    210                 215                 220                 


Ala Asn Leu Gly Gln Ser Val Thr Leu Val Cys Asp Ala Glu Gly Phe 
225                 230                 235                 240 


Pro Glu Pro Thr Met Ser Trp Thr Lys Asp Gly Glu Gln Ile Glu Gln 
                245                 250                 255     


Glu Glu Asp Asp Glu Lys Tyr Ile Phe Ser Asp Asp Ser Ser Gln Leu 
            260                 265                 270         


Thr Ile Lys Lys Val Asp Lys Asn Asp Glu Ala Glu Tyr Ile Cys Ile 
        275                 280                 285             


Ala Glu Asn Lys Ala Gly Glu Gln Asp Ala Thr Ile His Leu Lys Val 
    290                 295                 300                 


Phe Ala Lys Pro Lys Ile Thr Tyr Val Glu Asn Gln Thr Ala Met Glu 
305                 310                 315                 320 


Leu Glu Glu Gln Val Thr Leu Thr Cys Glu Ala Ser Gly Asp Pro Ile 
                325                 330                 335     


Pro Ser Ile Thr Trp Arg Thr Ser Thr Arg Asn Ile Ser Ser Glu Glu 
            340                 345                 350         


Lys Ala Ser Trp Thr Arg Pro Glu Lys Gln Glu Val His Ala Pro Trp 
        355                 360                 365             


Asn Trp Gln Val Gly Arg Gln Lys Gly Gln Ala Gly Ser Ala Gly Phe 
    370                 375                 380                 


Pro Gly Ser His Glu Thr Leu Asp Gly His Met Val Val Arg Ser His 
385                 390                 395                 400 


Ala Arg Val Ser Ser Leu Thr Leu Lys Ser Ile Gln Tyr Thr Asp Ala 
                405                 410                 415     


Gly Glu Tyr Ile Cys Thr Ala Ser Asn Thr Ile Gly Gln Asp Ser Gln 
            420                 425                 430         


Ser Met Tyr Leu Glu Val Gln Tyr Ala Pro Lys Leu Gln Gly Pro Val 
        435                 440                 445             


Ala Val Tyr Thr Trp Glu Gly Asn Gln Val Asn Ile Thr Cys Glu Val 
    450                 455                 460                 


Phe Ala Tyr Pro Ser Ala Thr Ile Ser Trp Phe Arg Asp Gly Gln Leu 
465                 470                 475                 480 


Leu Pro Ser Ser Asn Tyr Ser Asn Ile Lys Ile Tyr Asn Thr Pro Ser 
                485                 490                 495     


Ala Ser Tyr Leu Glu Val Thr Pro Asp Ser Glu Asn Asp Phe Gly Asn 
            500                 505                 510         


Tyr Asn Cys Thr Ala Val Asn Arg Ile Gly Gln Glu Ser Leu Glu Phe 
        515                 520                 525             


Ile Leu Val Gln Ala Asp Thr Pro Ser Ser Pro Ser Ile Asp Gln Val 
    530                 535                 540                 


Glu Pro Tyr Ser Ser Thr Ala Gln Val Gln Phe Asp Glu Pro Glu Ala 
545                 550                 555                 560 


Thr Gly Gly Val Pro Ile Leu Lys Tyr Lys Ala Glu Trp Arg Ala Val 
                565                 570                 575     


Gly Glu Glu Val Trp His Ser Lys Trp Tyr Asp Ala Lys Glu Ala Ser 
            580                 585                 590         


Met Glu Gly Ile Val Thr Ile Val Gly Leu Lys Pro Glu Thr Thr Tyr 
        595                 600                 605             


Ala Val Arg Leu Ala Ala Leu Asn Gly Lys Gly Leu Gly Glu Ile Ser 
    610                 615                 620                 


Ala Ala Ser Glu Phe Lys Thr Gln Pro Val Pro Gly Glu Pro Ser Ala 
625                 630                 635                 640 


Pro Lys Leu Glu Gly Gln Met Gly Glu Asp Gly Asn Ser Ile Lys Val 
                645                 650                 655     


Asn Leu Ile Lys Gln Asp Asp Gly Gly Ser Pro Ile Arg His Tyr Leu 
            660                 665                 670         


Val Arg Tyr Arg Ala Leu Ser Ser Glu Trp Lys Pro Glu Ile Arg Leu 
        675                 680                 685             


Pro Ser Gly Ser Asp His Val Met Leu Lys Ser Leu Asp Trp Asn Ala 
    690                 695                 700                 


Glu Tyr Glu Val Tyr Val Val Ala Glu Asn Gln Gln Gly Lys Ser Lys 
705                 710                 715                 720 


Ala Ala His Phe Val Phe Arg Thr Ser Ala Gln Pro Thr Ala Ile Pro 
                725                 730                 735     


Ala Asn Gly Ser Pro Thr Ser Gly Leu Ser Thr Gly Ala Ile Val Gly 
            740                 745                 750         


Ile Leu Ile Val Ile Phe Val Leu Leu Leu Val Val Val Asp Ile Thr 
        755                 760                 765             


Cys Tyr Phe Leu Asn Lys Cys Gly Leu Phe Met Cys Ile Ala Val Asn 
    770                 775                 780                 


Leu Cys Gly Lys Ala Gly Pro Gly Ala Lys Gly Lys Asp Met Glu Glu 
785                 790                 795                 800 


Gly Lys Ala Ala Phe Ser Lys Asp Glu Ser Lys Glu Pro Ile Val Glu 
                805                 810                 815     


Val Arg Thr Glu Glu Glu Arg Thr Pro Asn His Asp Gly Gly Lys His 
            820                 825                 830         


Thr Glu Pro Asn Glu Thr Thr Pro Leu Thr Glu Pro Glu Lys Gly Pro 
        835                 840                 845             


Val Glu Ala Lys Pro Glu Cys Gln Glu Thr Glu Thr Lys Pro Ala Pro 
    850                 855                 860                 


Ala Glu Val Lys Thr Val Pro Asn Asp Ala Thr Gln Thr Lys Glu Asn 
865                 870                 875                 880 


Glu Ser Lys Ala 
                


<210>  414
<211>  848
<212>  PRT
<213>  Homo sapiens

<400>  414

Met Leu Gln Thr Lys Asp Leu Ile Trp Thr Leu Phe Phe Leu Gly Thr 
1               5                   10                  15      


Ala Val Ser Leu Gln Val Asp Ile Val Pro Ser Gln Gly Glu Ile Ser 
            20                  25                  30          


Val Gly Glu Ser Lys Phe Phe Leu Cys Gln Val Ala Gly Asp Ala Lys 
        35                  40                  45              


Asp Lys Asp Ile Ser Trp Phe Ser Pro Asn Gly Glu Lys Leu Thr Pro 
    50                  55                  60                  


Asn Gln Gln Arg Ile Ser Val Val Trp Asn Asp Asp Ser Ser Ser Thr 
65                  70                  75                  80  


Leu Thr Ile Tyr Asn Ala Asn Ile Asp Asp Ala Gly Ile Tyr Lys Cys 
                85                  90                  95      


Val Val Thr Gly Glu Asp Gly Ser Glu Ser Glu Ala Thr Val Asn Val 
            100                 105                 110         


Lys Ile Phe Gln Lys Leu Met Phe Lys Asn Ala Pro Thr Pro Gln Glu 
        115                 120                 125             


Phe Arg Glu Gly Glu Asp Ala Val Ile Val Cys Asp Val Val Ser Ser 
    130                 135                 140                 


Leu Pro Pro Thr Ile Ile Trp Lys His Lys Gly Arg Asp Val Ile Leu 
145                 150                 155                 160 


Lys Lys Asp Val Arg Phe Ile Val Leu Ser Asn Asn Tyr Leu Gln Ile 
                165                 170                 175     


Arg Gly Ile Lys Lys Thr Asp Glu Gly Thr Tyr Arg Cys Glu Gly Arg 
            180                 185                 190         


Ile Leu Ala Arg Gly Glu Ile Asn Phe Lys Asp Ile Gln Val Ile Val 
        195                 200                 205             


Asn Val Pro Pro Thr Ile Gln Ala Arg Gln Asn Ile Val Asn Ala Thr 
    210                 215                 220                 


Ala Asn Leu Gly Gln Ser Val Thr Leu Val Cys Asp Ala Glu Gly Phe 
225                 230                 235                 240 


Pro Glu Pro Thr Met Ser Trp Thr Lys Asp Gly Glu Gln Ile Glu Gln 
                245                 250                 255     


Glu Glu Asp Asp Glu Lys Tyr Ile Phe Ser Asp Asp Ser Ser Gln Leu 
            260                 265                 270         


Thr Ile Lys Lys Val Asp Lys Asn Asp Glu Ala Glu Tyr Ile Cys Ile 
        275                 280                 285             


Ala Glu Asn Lys Ala Gly Glu Gln Asp Ala Thr Ile His Leu Lys Val 
    290                 295                 300                 


Phe Ala Lys Pro Lys Ile Thr Tyr Val Glu Asn Gln Thr Ala Met Glu 
305                 310                 315                 320 


Leu Glu Glu Gln Val Thr Leu Thr Cys Glu Ala Ser Gly Asp Pro Ile 
                325                 330                 335     


Pro Ser Ile Thr Trp Arg Thr Ser Thr Arg Asn Ile Ser Ser Glu Glu 
            340                 345                 350         


Lys Thr Leu Asp Gly His Met Val Val Arg Ser His Ala Arg Val Ser 
        355                 360                 365             


Ser Leu Thr Leu Lys Ser Ile Gln Tyr Thr Asp Ala Gly Glu Tyr Ile 
    370                 375                 380                 


Cys Thr Ala Ser Asn Thr Ile Gly Gln Asp Ser Gln Ser Met Tyr Leu 
385                 390                 395                 400 


Glu Val Gln Tyr Ala Pro Lys Leu Gln Gly Pro Val Ala Val Tyr Thr 
                405                 410                 415     


Trp Glu Gly Asn Gln Val Asn Ile Thr Cys Glu Val Phe Ala Tyr Pro 
            420                 425                 430         


Ser Ala Thr Ile Ser Trp Phe Arg Asp Gly Gln Leu Leu Pro Ser Ser 
        435                 440                 445             


Asn Tyr Ser Asn Ile Lys Ile Tyr Asn Thr Pro Ser Ala Ser Tyr Leu 
    450                 455                 460                 


Glu Val Thr Pro Asp Ser Glu Asn Asp Phe Gly Asn Tyr Asn Cys Thr 
465                 470                 475                 480 


Ala Val Asn Arg Ile Gly Gln Glu Ser Leu Glu Phe Ile Leu Val Gln 
                485                 490                 495     


Ala Asp Thr Pro Ser Ser Pro Ser Ile Asp Gln Val Glu Pro Tyr Ser 
            500                 505                 510         


Ser Thr Ala Gln Val Gln Phe Asp Glu Pro Glu Ala Thr Gly Gly Val 
        515                 520                 525             


Pro Ile Leu Lys Tyr Lys Ala Glu Trp Arg Ala Val Gly Glu Glu Val 
    530                 535                 540                 


Trp His Ser Lys Trp Tyr Asp Ala Lys Glu Ala Ser Met Glu Gly Ile 
545                 550                 555                 560 


Val Thr Ile Val Gly Leu Lys Pro Glu Thr Thr Tyr Ala Val Arg Leu 
                565                 570                 575     


Ala Ala Leu Asn Gly Lys Gly Leu Gly Glu Ile Ser Ala Ala Ser Glu 
            580                 585                 590         


Phe Lys Thr Gln Pro Val Pro Gly Glu Pro Ser Ala Pro Lys Leu Glu 
        595                 600                 605             


Gly Gln Met Gly Glu Asp Gly Asn Ser Ile Lys Val Asn Leu Ile Lys 
    610                 615                 620                 


Gln Asp Asp Gly Gly Ser Pro Ile Arg His Tyr Leu Val Arg Tyr Arg 
625                 630                 635                 640 


Ala Leu Ser Ser Glu Trp Lys Pro Glu Ile Arg Leu Pro Ser Gly Ser 
                645                 650                 655     


Asp His Val Met Leu Lys Ser Leu Asp Trp Asn Ala Glu Tyr Glu Val 
            660                 665                 670         


Tyr Val Val Ala Glu Asn Gln Gln Gly Lys Ser Lys Ala Ala His Phe 
        675                 680                 685             


Val Phe Arg Thr Ser Ala Gln Pro Thr Ala Ile Pro Ala Asn Gly Ser 
    690                 695                 700                 


Pro Thr Ser Gly Leu Ser Thr Gly Ala Ile Val Gly Ile Leu Ile Val 
705                 710                 715                 720 


Ile Phe Val Leu Leu Leu Val Val Val Asp Ile Thr Cys Tyr Phe Leu 
                725                 730                 735     


Asn Lys Cys Gly Leu Phe Met Cys Ile Ala Val Asn Leu Cys Gly Lys 
            740                 745                 750         


Ala Gly Pro Gly Ala Lys Gly Lys Asp Met Glu Glu Gly Lys Ala Ala 
        755                 760                 765             


Phe Ser Lys Asp Glu Ser Lys Glu Pro Ile Val Glu Val Arg Thr Glu 
    770                 775                 780                 


Glu Glu Arg Thr Pro Asn His Asp Gly Gly Lys His Thr Glu Pro Asn 
785                 790                 795                 800 


Glu Thr Thr Pro Leu Thr Glu Pro Glu Lys Gly Pro Val Glu Ala Lys 
                805                 810                 815     


Pro Glu Cys Gln Glu Thr Glu Thr Lys Pro Ala Pro Ala Glu Val Lys 
            820                 825                 830         


Thr Val Pro Asn Asp Ala Thr Gln Thr Lys Glu Asn Glu Ser Lys Ala 
        835                 840                 845             


<210>  415
<211>  884
<212>  PRT
<213>  Homo sapiens

<400>  415

Met Leu Gln Thr Lys Asp Leu Ile Trp Thr Leu Phe Phe Leu Gly Thr 
1               5                   10                  15      


Ala Val Ser Leu Gln Val Asp Ile Val Pro Ser Gln Gly Glu Ile Ser 
            20                  25                  30          


Val Gly Glu Ser Lys Phe Phe Leu Cys Gln Val Ala Gly Asp Ala Lys 
        35                  40                  45              


Asp Lys Asp Ile Ser Trp Phe Ser Pro Asn Gly Glu Lys Leu Thr Pro 
    50                  55                  60                  


Asn Gln Gln Arg Ile Ser Val Val Trp Asn Asp Asp Ser Ser Ser Thr 
65                  70                  75                  80  


Leu Thr Ile Tyr Asn Ala Asn Ile Asp Asp Ala Gly Ile Tyr Lys Cys 
                85                  90                  95      


Val Val Thr Gly Glu Asp Gly Ser Glu Ser Glu Ala Thr Val Asn Val 
            100                 105                 110         


Lys Ile Phe Gln Lys Leu Met Phe Lys Asn Ala Pro Thr Pro Gln Glu 
        115                 120                 125             


Phe Arg Glu Gly Glu Asp Ala Val Ile Val Cys Asp Val Val Ser Ser 
    130                 135                 140                 


Leu Pro Pro Thr Ile Ile Trp Lys His Lys Gly Arg Asp Val Ile Leu 
145                 150                 155                 160 


Lys Lys Asp Val Arg Phe Ile Val Leu Ser Asn Asn Tyr Leu Gln Ile 
                165                 170                 175     


Arg Gly Ile Lys Lys Thr Asp Glu Gly Thr Tyr Arg Cys Glu Gly Arg 
            180                 185                 190         


Ile Leu Ala Arg Gly Glu Ile Asn Phe Lys Asp Ile Gln Val Ile Val 
        195                 200                 205             


Asn Val Pro Pro Thr Ile Gln Ala Arg Gln Asn Ile Val Asn Ala Thr 
    210                 215                 220                 


Ala Asn Leu Gly Gln Ser Val Thr Leu Val Cys Asp Ala Glu Gly Phe 
225                 230                 235                 240 


Pro Glu Pro Thr Met Ser Trp Thr Lys Asp Gly Glu Gln Ile Glu Gln 
                245                 250                 255     


Glu Glu Asp Asp Glu Lys Tyr Ile Phe Ser Asp Asp Ser Ser Gln Leu 
            260                 265                 270         


Thr Ile Lys Lys Val Asp Lys Asn Asp Glu Ala Glu Tyr Ile Cys Ile 
        275                 280                 285             


Ala Glu Asn Lys Ala Gly Glu Gln Asp Ala Thr Ile His Leu Lys Val 
    290                 295                 300                 


Phe Ala Lys Pro Lys Ile Thr Tyr Val Glu Asn Gln Thr Ala Met Glu 
305                 310                 315                 320 


Leu Glu Glu Gln Val Thr Leu Thr Cys Glu Ala Ser Gly Asp Pro Ile 
                325                 330                 335     


Pro Ser Ile Thr Trp Arg Thr Ser Thr Arg Asn Ile Ser Ser Glu Glu 
            340                 345                 350         


Lys Ala Ser Trp Thr Arg Pro Glu Lys Gln Glu Val His Ala Pro Trp 
        355                 360                 365             


Asn Trp Gln Val Gly Arg Gln Lys Gly Gln Ala Gly Ser Ala Gly Phe 
    370                 375                 380                 


Pro Gly Ser His Glu Thr Leu Asp Gly His Met Val Val Arg Ser His 
385                 390                 395                 400 


Ala Arg Val Ser Ser Leu Thr Leu Lys Ser Ile Gln Tyr Thr Asp Ala 
                405                 410                 415     


Gly Glu Tyr Ile Cys Thr Ala Ser Asn Thr Ile Gly Gln Asp Ser Gln 
            420                 425                 430         


Ser Met Tyr Leu Glu Val Gln Tyr Ala Pro Lys Leu Gln Gly Pro Val 
        435                 440                 445             


Ala Val Tyr Thr Trp Glu Gly Asn Gln Val Asn Ile Thr Cys Glu Val 
    450                 455                 460                 


Phe Ala Tyr Pro Ser Ala Thr Ile Ser Trp Phe Arg Asp Gly Gln Leu 
465                 470                 475                 480 


Leu Pro Ser Ser Asn Tyr Ser Asn Ile Lys Ile Tyr Asn Thr Pro Ser 
                485                 490                 495     


Ala Ser Tyr Leu Glu Val Thr Pro Asp Ser Glu Asn Asp Phe Gly Asn 
            500                 505                 510         


Tyr Asn Cys Thr Ala Val Asn Arg Ile Gly Gln Glu Ser Leu Glu Phe 
        515                 520                 525             


Ile Leu Val Gln Ala Asp Thr Pro Ser Ser Pro Ser Ile Asp Gln Val 
    530                 535                 540                 


Glu Pro Tyr Ser Ser Thr Ala Gln Val Gln Phe Asp Glu Pro Glu Ala 
545                 550                 555                 560 


Thr Gly Gly Val Pro Ile Leu Lys Tyr Lys Ala Glu Trp Arg Ala Val 
                565                 570                 575     


Gly Glu Glu Val Trp His Ser Lys Trp Tyr Asp Ala Lys Glu Ala Ser 
            580                 585                 590         


Met Glu Gly Ile Val Thr Ile Val Gly Leu Lys Pro Glu Thr Thr Tyr 
        595                 600                 605             


Ala Val Arg Leu Ala Ala Leu Asn Gly Lys Gly Leu Gly Glu Ile Ser 
    610                 615                 620                 


Ala Ala Ser Glu Phe Lys Thr Gln Pro Val Gln Gly Glu Pro Ser Ala 
625                 630                 635                 640 


Pro Lys Leu Glu Gly Gln Met Gly Glu Asp Gly Asn Ser Ile Lys Val 
                645                 650                 655     


Asn Leu Ile Lys Gln Asp Asp Gly Gly Ser Pro Ile Arg His Tyr Leu 
            660                 665                 670         


Val Arg Tyr Arg Ala Leu Ser Ser Glu Trp Lys Pro Glu Ile Arg Leu 
        675                 680                 685             


Pro Ser Gly Ser Asp His Val Met Leu Lys Ser Leu Asp Trp Asn Ala 
    690                 695                 700                 


Glu Tyr Glu Val Tyr Val Val Ala Glu Asn Gln Gln Gly Lys Ser Lys 
705                 710                 715                 720 


Ala Ala His Phe Val Phe Arg Thr Ser Ala Gln Pro Thr Ala Ile Pro 
                725                 730                 735     


Ala Asn Gly Ser Pro Thr Ser Gly Leu Ser Thr Gly Ala Ile Val Gly 
            740                 745                 750         


Ile Leu Ile Val Ile Phe Val Leu Leu Leu Val Val Val Asp Ile Thr 
        755                 760                 765             


Cys Tyr Phe Leu Asn Lys Cys Gly Leu Phe Met Cys Ile Ala Val Asn 
    770                 775                 780                 


Leu Cys Gly Lys Ala Gly Pro Gly Ala Lys Gly Lys Asp Met Glu Glu 
785                 790                 795                 800 


Gly Lys Ala Ala Phe Ser Lys Asp Glu Ser Lys Glu Pro Ile Val Glu 
                805                 810                 815     


Val Arg Thr Glu Glu Glu Arg Thr Pro Asn His Asp Gly Gly Lys His 
            820                 825                 830         


Thr Glu Pro Asn Glu Thr Thr Pro Leu Thr Glu Pro Glu Lys Gly Pro 
        835                 840                 845             


Val Glu Ala Lys Pro Glu Cys Gln Glu Thr Glu Thr Lys Pro Ala Pro 
    850                 855                 860                 


Ala Glu Val Lys Thr Val Pro Asn Asp Ala Thr Gln Thr Lys Glu Asn 
865                 870                 875                 880 


Glu Ser Lys Ala 
                


<210>  416
<211>  136
<212>  PRT
<213>  Homo sapiens

<400>  416

Met Leu Gln Thr Lys Asp Leu Ile Trp Thr Leu Phe Phe Leu Gly Thr 
1               5                   10                  15      


Ala Gly Glu Pro Ser Ala Pro Lys Leu Glu Gly Gln Met Gly Glu Asp 
            20                  25                  30          


Gly Asn Ser Ile Lys Val Asn Leu Ile Lys Gln Asp Asp Gly Gly Ser 
        35                  40                  45              


Pro Ile Arg His Tyr Leu Val Arg Tyr Arg Ala Leu Ser Ser Glu Trp 
    50                  55                  60                  


Lys Pro Glu Ile Arg Leu Pro Ser Gly Ser Asp His Val Met Leu Lys 
65                  70                  75                  80  


Ser Leu Asp Trp Asn Ala Glu Tyr Glu Val Tyr Val Val Ala Glu Asn 
                85                  90                  95      


Gln Gln Gly Lys Ser Lys Ala Ala His Phe Val Phe Arg Thr Ser Ala 
            100                 105                 110         


Gln Pro Thr Ala Ile Pro Ala Asn Gly Ser Pro Thr Ser Gly Leu Ser 
        115                 120                 125             


Thr Gly Ala Ile Val Gly Ile Leu 
    130                 135     


<210>  417
<211>  726
<212>  PRT
<213>  Homo sapiens

<400>  417

Met Leu Gln Thr Lys Asp Leu Ile Trp Thr Leu Phe Phe Leu Gly Thr 
1               5                   10                  15      


Ala Val Ser Leu Gln Val Asp Ile Val Pro Ser Gln Gly Glu Ile Ser 
            20                  25                  30          


Val Gly Glu Ser Lys Phe Phe Leu Cys Gln Val Ala Gly Asp Ala Lys 
        35                  40                  45              


Asp Lys Asp Ile Ser Trp Phe Ser Pro Asn Gly Glu Lys Leu Thr Pro 
    50                  55                  60                  


Asn Gln Gln Arg Ile Ser Val Val Trp Asn Asp Asp Ser Ser Ser Thr 
65                  70                  75                  80  


Leu Thr Ile Tyr Asn Ala Asn Ile Asp Asp Ala Gly Ile Tyr Lys Cys 
                85                  90                  95      


Val Val Thr Gly Glu Asp Gly Ser Glu Ser Glu Ala Thr Val Asn Val 
            100                 105                 110         


Lys Ile Phe Gln Lys Leu Met Phe Lys Asn Ala Pro Thr Pro Gln Glu 
        115                 120                 125             


Phe Arg Glu Gly Glu Asp Ala Val Ile Val Cys Asp Val Val Ser Ser 
    130                 135                 140                 


Leu Pro Pro Thr Ile Ile Trp Lys His Lys Gly Arg Asp Val Ile Leu 
145                 150                 155                 160 


Lys Lys Asp Val Arg Phe Ile Val Leu Ser Asn Asn Tyr Leu Gln Ile 
                165                 170                 175     


Arg Gly Ile Lys Lys Thr Asp Glu Gly Thr Tyr Arg Cys Glu Gly Arg 
            180                 185                 190         


Ile Leu Ala Arg Gly Glu Ile Asn Phe Lys Asp Ile Gln Val Ile Val 
        195                 200                 205             


Asn Val Pro Pro Thr Ile Gln Ala Arg Gln Asn Ile Val Asn Ala Thr 
    210                 215                 220                 


Ala Asn Leu Gly Gln Ser Val Thr Leu Val Cys Asp Ala Glu Gly Phe 
225                 230                 235                 240 


Pro Glu Pro Thr Met Ser Trp Thr Lys Asp Gly Glu Gln Ile Glu Gln 
                245                 250                 255     


Glu Glu Asp Asp Glu Lys Tyr Ile Phe Ser Asp Asp Ser Ser Gln Leu 
            260                 265                 270         


Thr Ile Lys Lys Val Asp Lys Asn Asp Glu Ala Glu Tyr Ile Cys Ile 
        275                 280                 285             


Ala Glu Asn Lys Ala Gly Glu Gln Asp Ala Thr Ile His Leu Lys Val 
    290                 295                 300                 


Phe Ala Lys Pro Lys Ile Thr Tyr Val Glu Asn Gln Thr Ala Met Glu 
305                 310                 315                 320 


Leu Glu Glu Gln Val Thr Leu Thr Cys Glu Ala Ser Gly Asp Pro Ile 
                325                 330                 335     


Pro Ser Ile Thr Trp Arg Thr Ser Thr Arg Asn Ile Ser Ser Glu Glu 
            340                 345                 350         


Lys Thr Leu Asp Gly His Met Val Val Arg Ser His Ala Arg Val Ser 
        355                 360                 365             


Ser Leu Thr Leu Lys Ser Ile Gln Tyr Thr Asp Ala Gly Glu Tyr Ile 
    370                 375                 380                 


Cys Thr Ala Ser Asn Thr Ile Gly Gln Asp Ser Gln Ser Met Tyr Leu 
385                 390                 395                 400 


Glu Val Gln Tyr Ala Pro Lys Leu Gln Gly Pro Val Ala Val Tyr Thr 
                405                 410                 415     


Trp Glu Gly Asn Gln Val Asn Ile Thr Cys Glu Val Phe Ala Tyr Pro 
            420                 425                 430         


Ser Ala Thr Ile Ser Trp Phe Arg Asp Gly Gln Leu Leu Pro Ser Ser 
        435                 440                 445             


Asn Tyr Ser Asn Ile Lys Ile Tyr Asn Thr Pro Ser Ala Ser Tyr Leu 
    450                 455                 460                 


Glu Val Thr Pro Asp Ser Glu Asn Asp Phe Gly Asn Tyr Asn Cys Thr 
465                 470                 475                 480 


Ala Val Asn Arg Ile Gly Gln Glu Ser Leu Glu Phe Ile Leu Val Gln 
                485                 490                 495     


Ala Asp Thr Pro Ser Ser Pro Ser Ile Asp Gln Val Glu Pro Tyr Ser 
            500                 505                 510         


Ser Thr Ala Gln Val Gln Phe Asp Glu Pro Glu Ala Thr Gly Gly Val 
        515                 520                 525             


Pro Ile Leu Lys Tyr Lys Ala Glu Trp Arg Ala Val Gly Glu Glu Val 
    530                 535                 540                 


Trp His Ser Lys Trp Tyr Asp Ala Lys Glu Ala Ser Met Glu Gly Ile 
545                 550                 555                 560 


Val Thr Ile Val Gly Leu Lys Pro Glu Thr Thr Tyr Ala Val Arg Leu 
                565                 570                 575     


Ala Ala Leu Asn Gly Lys Gly Leu Gly Glu Ile Ser Ala Ala Ser Glu 
            580                 585                 590         


Phe Lys Thr Gln Pro Val Gln Gly Glu Pro Ser Ala Pro Lys Leu Glu 
        595                 600                 605             


Gly Gln Met Gly Glu Asp Gly Asn Ser Ile Lys Val Asn Leu Ile Lys 
    610                 615                 620                 


Gln Asp Asp Gly Gly Ser Pro Ile Arg His Tyr Leu Val Arg Tyr Arg 
625                 630                 635                 640 


Ala Leu Ser Ser Glu Trp Lys Pro Glu Ile Arg Leu Pro Ser Gly Ser 
                645                 650                 655     


Asp His Val Met Leu Lys Ser Leu Asp Trp Asn Ala Glu Tyr Glu Val 
            660                 665                 670         


Tyr Val Val Ala Glu Asn Gln Gln Gly Lys Ser Lys Ala Ala His Phe 
        675                 680                 685             


Val Phe Arg Thr Ser Ala Gln Pro Thr Ala Ile Pro Ala Thr Leu Gly 
    690                 695                 700                 


Gly Asn Ser Ala Ser Tyr Thr Phe Val Ser Leu Leu Phe Ser Ala Val 
705                 710                 715                 720 


Thr Leu Leu Leu Leu Cys 
                725     


<210>  418
<211>  761
<212>  PRT
<213>  Homo sapiens

<400>  418

Met Leu Gln Thr Lys Asp Leu Ile Trp Thr Leu Phe Phe Leu Gly Thr 
1               5                   10                  15      


Ala Val Ser Leu Gln Val Asp Ile Val Pro Ser Gln Gly Glu Ile Ser 
            20                  25                  30          


Val Gly Glu Ser Lys Phe Phe Leu Cys Gln Val Ala Gly Asp Ala Lys 
        35                  40                  45              


Asp Lys Asp Ile Ser Trp Phe Ser Pro Asn Gly Glu Lys Leu Thr Pro 
    50                  55                  60                  


Asn Gln Gln Arg Ile Ser Val Val Trp Asn Asp Asp Ser Ser Ser Thr 
65                  70                  75                  80  


Leu Thr Ile Tyr Asn Ala Asn Ile Asp Asp Ala Gly Ile Tyr Lys Cys 
                85                  90                  95      


Val Val Thr Gly Glu Asp Gly Ser Glu Ser Glu Ala Thr Val Asn Val 
            100                 105                 110         


Lys Ile Phe Gln Lys Leu Met Phe Lys Asn Ala Pro Thr Pro Gln Glu 
        115                 120                 125             


Phe Arg Glu Gly Glu Asp Ala Val Ile Val Cys Asp Val Val Ser Ser 
    130                 135                 140                 


Leu Pro Pro Thr Ile Ile Trp Lys His Lys Gly Arg Asp Val Ile Leu 
145                 150                 155                 160 


Lys Lys Asp Val Arg Phe Ile Val Leu Ser Asn Asn Tyr Leu Gln Ile 
                165                 170                 175     


Arg Gly Ile Lys Lys Thr Asp Glu Gly Thr Tyr Arg Cys Glu Gly Arg 
            180                 185                 190         


Ile Leu Ala Arg Gly Glu Ile Asn Phe Lys Asp Ile Gln Val Ile Val 
        195                 200                 205             


Asn Val Pro Pro Thr Ile Gln Ala Arg Gln Asn Ile Val Asn Ala Thr 
    210                 215                 220                 


Ala Asn Leu Gly Gln Ser Val Thr Leu Val Cys Asp Ala Glu Gly Phe 
225                 230                 235                 240 


Pro Glu Pro Thr Met Ser Trp Thr Lys Asp Gly Glu Gln Ile Glu Gln 
                245                 250                 255     


Glu Glu Asp Asp Glu Lys Tyr Ile Phe Ser Asp Asp Ser Ser Gln Leu 
            260                 265                 270         


Thr Ile Lys Lys Val Asp Lys Asn Asp Glu Ala Glu Tyr Ile Cys Ile 
        275                 280                 285             


Ala Glu Asn Lys Ala Gly Glu Gln Asp Ala Thr Ile His Leu Lys Val 
    290                 295                 300                 


Phe Ala Lys Pro Lys Ile Thr Tyr Val Glu Asn Gln Thr Ala Met Glu 
305                 310                 315                 320 


Leu Glu Glu Gln Val Thr Leu Thr Cys Glu Ala Ser Gly Asp Pro Ile 
                325                 330                 335     


Pro Ser Ile Thr Trp Arg Thr Ser Thr Arg Asn Ile Ser Ser Glu Glu 
            340                 345                 350         


Lys Thr Leu Asp Gly His Met Val Val Arg Ser His Ala Arg Val Ser 
        355                 360                 365             


Ser Leu Thr Leu Lys Ser Ile Gln Tyr Thr Asp Ala Gly Glu Tyr Ile 
    370                 375                 380                 


Cys Thr Ala Ser Asn Thr Ile Gly Gln Asp Ser Gln Ser Met Tyr Leu 
385                 390                 395                 400 


Glu Val Gln Tyr Ala Pro Lys Leu Gln Gly Pro Val Ala Val Tyr Thr 
                405                 410                 415     


Trp Glu Gly Asn Gln Val Asn Ile Thr Cys Glu Val Phe Ala Tyr Pro 
            420                 425                 430         


Ser Ala Thr Ile Ser Trp Phe Arg Asp Gly Gln Leu Leu Pro Ser Ser 
        435                 440                 445             


Asn Tyr Ser Asn Ile Lys Ile Tyr Asn Thr Pro Ser Ala Ser Tyr Leu 
    450                 455                 460                 


Glu Val Thr Pro Asp Ser Glu Asn Asp Phe Gly Asn Tyr Asn Cys Thr 
465                 470                 475                 480 


Ala Val Asn Arg Ile Gly Gln Glu Ser Leu Glu Phe Ile Leu Val Gln 
                485                 490                 495     


Ala Asp Thr Pro Ser Ser Pro Ser Ile Asp Gln Val Glu Pro Tyr Ser 
            500                 505                 510         


Ser Thr Ala Gln Val Gln Phe Asp Glu Pro Glu Ala Thr Gly Gly Val 
        515                 520                 525             


Pro Ile Leu Lys Tyr Lys Ala Glu Trp Arg Ala Val Gly Glu Glu Val 
    530                 535                 540                 


Trp His Ser Lys Trp Tyr Asp Ala Lys Glu Ala Ser Met Glu Gly Ile 
545                 550                 555                 560 


Val Thr Ile Val Gly Leu Lys Pro Glu Thr Thr Tyr Ala Val Arg Leu 
                565                 570                 575     


Ala Ala Leu Asn Gly Lys Gly Leu Gly Glu Ile Ser Ala Ala Ser Glu 
            580                 585                 590         


Phe Lys Thr Gln Pro Val His Ser Pro Pro Pro Pro Ala Ser Ala Ser 
        595                 600                 605             


Ser Ser Thr Pro Val Pro Leu Ser Pro Pro Asp Thr Thr Trp Pro Leu 
    610                 615                 620                 


Pro Ala Leu Ala Thr Thr Glu Pro Ala Thr Gly Glu Pro Ser Ala Pro 
625                 630                 635                 640 


Lys Leu Glu Gly Gln Met Gly Glu Asp Gly Asn Ser Ile Lys Val Asn 
                645                 650                 655     


Leu Ile Lys Gln Asp Asp Gly Gly Ser Pro Ile Arg His Tyr Leu Val 
            660                 665                 670         


Arg Tyr Arg Ala Leu Ser Ser Glu Trp Lys Pro Glu Ile Arg Leu Pro 
        675                 680                 685             


Ser Gly Ser Asp His Val Met Leu Lys Ser Leu Asp Trp Asn Ala Glu 
    690                 695                 700                 


Tyr Glu Val Tyr Val Val Ala Glu Asn Gln Gln Gly Lys Ser Lys Ala 
705                 710                 715                 720 


Ala His Phe Val Phe Arg Thr Ser Ala Gln Pro Thr Ala Ile Pro Ala 
                725                 730                 735     


Thr Leu Gly Gly Asn Ser Ala Ser Tyr Thr Phe Val Ser Leu Leu Phe 
            740                 745                 750         


Ser Ala Val Thr Leu Leu Leu Leu Cys 
        755                 760     


<210>  419
<211>  761
<212>  PRT
<213>  Homo sapiens

<400>  419

Met Leu Gln Thr Lys Asp Leu Ile Trp Thr Leu Phe Phe Leu Gly Thr 
1               5                   10                  15      


Ala Val Ser Leu Gln Val Asp Ile Val Pro Ser Gln Gly Glu Ile Ser 
            20                  25                  30          


Val Gly Glu Ser Lys Phe Phe Leu Cys Gln Val Ala Gly Asp Ala Lys 
        35                  40                  45              


Asp Lys Asp Ile Ser Trp Phe Ser Pro Asn Gly Glu Lys Leu Thr Pro 
    50                  55                  60                  


Asn Gln Gln Arg Ile Ser Val Val Trp Asn Asp Asp Ser Ser Ser Thr 
65                  70                  75                  80  


Leu Thr Ile Tyr Asn Ala Asn Ile Asp Asp Ala Gly Ile Tyr Lys Cys 
                85                  90                  95      


Val Val Thr Gly Glu Asp Gly Ser Glu Ser Glu Ala Thr Val Asn Val 
            100                 105                 110         


Lys Ile Phe Gln Lys Leu Met Phe Lys Asn Ala Pro Thr Pro Gln Glu 
        115                 120                 125             


Phe Arg Glu Gly Glu Asp Ala Val Ile Val Cys Asp Val Val Ser Ser 
    130                 135                 140                 


Leu Pro Pro Thr Ile Ile Trp Lys His Lys Gly Arg Asp Val Ile Leu 
145                 150                 155                 160 


Lys Lys Asp Val Arg Phe Ile Val Leu Ser Asn Asn Tyr Leu Gln Ile 
                165                 170                 175     


Arg Gly Ile Lys Lys Thr Asp Glu Gly Thr Tyr Arg Cys Glu Gly Arg 
            180                 185                 190         


Ile Leu Ala Arg Gly Glu Ile Asn Phe Lys Asp Ile Gln Val Ile Val 
        195                 200                 205             


Asn Val Pro Pro Thr Ile Gln Ala Arg Gln Asn Ile Val Asn Ala Thr 
    210                 215                 220                 


Ala Asn Leu Gly Gln Ser Val Thr Leu Val Cys Asp Ala Glu Gly Phe 
225                 230                 235                 240 


Pro Glu Pro Thr Met Ser Trp Thr Lys Asp Gly Glu Gln Ile Glu Gln 
                245                 250                 255     


Glu Glu Asp Asp Glu Lys Tyr Ile Phe Ser Asp Asp Ser Ser Gln Leu 
            260                 265                 270         


Thr Ile Lys Lys Val Asp Lys Asn Asp Glu Ala Glu Tyr Ile Cys Ile 
        275                 280                 285             


Ala Glu Asn Lys Ala Gly Glu Gln Asp Ala Thr Ile His Leu Lys Val 
    290                 295                 300                 


Phe Ala Lys Pro Lys Ile Thr Tyr Val Glu Asn Gln Thr Ala Met Glu 
305                 310                 315                 320 


Leu Glu Glu Gln Val Thr Leu Thr Cys Glu Ala Ser Gly Asp Pro Ile 
                325                 330                 335     


Pro Ser Ile Thr Trp Arg Thr Ser Thr Arg Asn Ile Ser Ser Glu Glu 
            340                 345                 350         


Lys Thr Leu Asp Gly His Met Val Val Arg Ser His Ala Arg Val Ser 
        355                 360                 365             


Ser Leu Thr Leu Lys Ser Ile Gln Tyr Thr Asp Ala Gly Glu Tyr Ile 
    370                 375                 380                 


Cys Thr Ala Ser Asn Thr Ile Gly Gln Asp Ser Gln Ser Met Tyr Leu 
385                 390                 395                 400 


Glu Val Gln Tyr Ala Pro Lys Leu Gln Gly Pro Val Ala Val Tyr Thr 
                405                 410                 415     


Trp Glu Gly Asn Gln Val Asn Ile Thr Cys Glu Val Phe Ala Tyr Pro 
            420                 425                 430         


Ser Ala Thr Ile Ser Trp Phe Arg Asp Gly Gln Leu Leu Pro Ser Ser 
        435                 440                 445             


Asn Tyr Ser Asn Ile Lys Ile Tyr Asn Thr Pro Ser Ala Ser Tyr Leu 
    450                 455                 460                 


Glu Val Thr Pro Asp Ser Glu Asn Asp Phe Gly Asn Tyr Asn Cys Thr 
465                 470                 475                 480 


Ala Val Asn Arg Ile Gly Gln Glu Ser Leu Glu Phe Ile Leu Val Gln 
                485                 490                 495     


Ala Asp Thr Pro Ser Ser Pro Ser Ile Asp Gln Val Glu Pro Tyr Ser 
            500                 505                 510         


Ser Thr Ala Gln Val Gln Phe Asp Glu Pro Glu Ala Thr Gly Gly Val 
        515                 520                 525             


Pro Ile Leu Lys Tyr Lys Ala Glu Trp Arg Ala Val Gly Glu Glu Val 
    530                 535                 540                 


Trp His Ser Lys Trp Tyr Asp Ala Lys Glu Ala Ser Met Glu Gly Ile 
545                 550                 555                 560 


Val Thr Ile Val Gly Leu Lys Pro Glu Thr Thr Tyr Ala Val Arg Leu 
                565                 570                 575     


Ala Ala Leu Asn Gly Lys Gly Leu Gly Glu Ile Ser Ala Ala Ser Glu 
            580                 585                 590         


Phe Lys Thr Gln Pro Val His Ser Pro Pro Pro Pro Ala Ser Ala Ser 
        595                 600                 605             


Ser Ser Thr Pro Val Pro Leu Ser Pro Pro Asp Thr Thr Trp Pro Leu 
    610                 615                 620                 


Pro Ala Leu Ala Thr Thr Glu Pro Ala Lys Gly Glu Pro Ser Ala Pro 
625                 630                 635                 640 


Lys Leu Glu Gly Gln Met Gly Glu Asp Gly Asn Ser Ile Lys Val Asn 
                645                 650                 655     


Leu Ile Lys Gln Asp Asp Gly Gly Ser Pro Ile Arg His Tyr Leu Val 
            660                 665                 670         


Arg Tyr Arg Ala Leu Ser Ser Glu Trp Lys Pro Glu Ile Arg Leu Pro 
        675                 680                 685             


Ser Gly Ser Asp His Val Met Leu Lys Ser Leu Asp Trp Asn Ala Glu 
    690                 695                 700                 


Tyr Glu Val Tyr Val Val Ala Glu Asn Gln Gln Gly Lys Ser Lys Ala 
705                 710                 715                 720 


Ala His Phe Val Phe Arg Thr Ser Ala Gln Pro Thr Ala Ile Pro Ala 
                725                 730                 735     


Thr Leu Gly Gly Asn Ser Ala Ser Tyr Thr Phe Val Ser Leu Leu Phe 
            740                 745                 750         


Ser Ala Val Thr Leu Leu Leu Leu Cys 
        755                 760     


<210>  420
<211>  88
<212>  PRT
<213>  Homo sapiens

<400>  420

Met Ser Asp Ile Leu Arg Glu Leu Leu Cys Val Ser Glu Lys Ala Ala 
1               5                   10                  15      


Asn Ile Ala Arg Ala Cys Arg Gln Gln Glu Ala Leu Phe Gln Leu Leu 
            20                  25                  30          


Ile Glu Glu Lys Lys Glu Gly Glu Lys Asn Lys Lys Phe Ala Val Asp 
        35                  40                  45              


Phe Lys Thr Leu Ala Asp Val Leu Val Gln Glu Val Ile Lys Gln Asn 
    50                  55                  60                  


Met Glu Asn Lys Phe Pro Gly Leu Glu Lys Asn Ile Phe Gly Glu Glu 
65                  70                  75                  80  


Ser Asn Glu Phe Thr Asn Asp Trp 
                85              


<210>  421
<211>  190
<212>  PRT
<213>  Homo sapiens

<400>  421

Met Ser Asp Ile Leu Arg Glu Leu Leu Cys Val Ser Glu Lys Ala Ala 
1               5                   10                  15      


Asn Ile Ala Arg Ala Cys Arg Gln Gln Glu Ala Leu Phe Gln Leu Leu 
            20                  25                  30          


Ile Glu Glu Lys Lys Glu Gly Glu Lys Asn Lys Lys Phe Ala Val Asp 
        35                  40                  45              


Phe Lys Thr Leu Ala Asp Val Leu Val Gln Glu Val Ile Lys Gln Asn 
    50                  55                  60                  


Met Glu Asn Lys Phe Pro Gly Leu Glu Lys Asn Ile Phe Gly Glu Glu 
65                  70                  75                  80  


Ser Asn Glu Phe Thr Asn Asp Trp Gly Glu Lys Ile Thr Leu Arg Leu 
                85                  90                  95      


Cys Ser Thr Glu Glu Glu Thr Ala Glu Leu Leu Ser Lys Val Leu Asn 
            100                 105                 110         


Gly Asn Lys Val Ala Ser Glu Ala Leu Ala Arg Val Val His Gln Asp 
        115                 120                 125             


Val Ala Phe Thr Asp Pro Thr Leu Asp Ser Thr Glu Ile Asn Val Pro 
    130                 135                 140                 


Gln Asp Ile Leu Gly Ile Trp Val Asp Pro Ile Asp Ser Thr Tyr Gln 
145                 150                 155                 160 


Tyr Ile Lys Gly Ser Ala Asp Ile Lys Ser Asn Gln Gly Ile Phe Pro 
                165                 170                 175     


Cys Gly Leu Gln Cys Val Thr Ile Leu Ile Gly Val Tyr Asp 
            180                 185                 190 


<210>  422
<211>  30
<212>  PRT
<213>  Homo sapiens

<400>  422

Met Ser Asp Ile Leu Arg Glu Leu Leu Cys Val Ser Glu Lys Ala Ala 
1               5                   10                  15      


Asn Ile Ala Arg Ala Cys Arg Gln Gln Glu Ala Leu Phe Gln 
            20                  25                  30  


<210>  423
<211>  68
<212>  PRT
<213>  Homo sapiens

<400>  423

Met Ser Asp Ile Leu Arg Glu Leu Leu Cys Val Ser Glu Lys Ala Ala 
1               5                   10                  15      


Asn Ile Ala Arg Ala Cys Arg Gln Gln Glu Ala Leu Phe Gln Leu Leu 
            20                  25                  30          


Ile Glu Glu Lys Lys Glu Gly Glu Lys Asn Lys Lys Phe Ala Val Asp 
        35                  40                  45              


Phe Lys Thr Leu Ala Asp Val Leu Val Gln Glu Val Ile Lys Gln Asn 
    50                  55                  60                  


Met Glu Asn Lys 
65              


<210>  424
<211>  831
<212>  PRT
<213>  Homo sapiens

<400>  424

Met Ser Lys Lys Gly Arg Ser Lys Gly Glu Lys Pro Glu Met Glu Thr 
1               5                   10                  15      


Asp Ala Val Gln Met Ala Asn Glu Glu Leu Arg Ala Lys Leu Thr Ser 
            20                  25                  30          


Ile Gln Ile Glu Phe Gln Gln Glu Lys Ser Lys Val Gly Lys Leu Arg 
        35                  40                  45              


Glu Arg Leu Gln Glu Ala Lys Leu Glu Arg Glu Gln Glu Gln Arg Arg 
    50                  55                  60                  


His Thr Ala Tyr Ile Ser Glu Leu Lys Ala Lys Leu His Glu Glu Lys 
65                  70                  75                  80  


Thr Lys Glu Leu Gln Ala Leu Arg Glu Gly Leu Ile Arg Gln His Glu 
                85                  90                  95      


Gln Glu Ala Ala Arg Thr Ala Lys Ile Lys Glu Gly Glu Leu Gln Arg 
            100                 105                 110         


Leu Gln Ala Thr Leu Asn Val Leu Arg Asp Gly Ala Ala Asp Lys Val 
        115                 120                 125             


Lys Thr Ala Leu Leu Thr Glu Ala Arg Glu Glu Ala Arg Arg Ala Phe 
    130                 135                 140                 


Asp Gly Glu Arg Leu Arg Leu Gln Gln Glu Ile Leu Glu Leu Lys Ala 
145                 150                 155                 160 


Ala Arg Lys Gln Ala Glu Glu Ala Leu Ser Asn Cys Met Gln Ala Asp 
                165                 170                 175     


Lys Thr Lys Ala Ala Asp Leu Arg Ala Ala Tyr Gln Ala His Gln Asp 
            180                 185                 190         


Glu Val His Arg Ile Lys Arg Glu Cys Glu Arg Asp Ile Arg Arg Leu 
        195                 200                 205             


Met Asp Glu Ile Lys Gly Lys Asp Arg Val Ile Leu Ala Leu Glu Lys 
    210                 215                 220                 


Glu Leu Gly Val Gln Ala Gly Gln Thr Gln Lys Leu Leu Leu Gln Lys 
225                 230                 235                 240 


Glu Ala Leu Asp Glu Gln Leu Val Gln Val Lys Glu Ala Glu Arg His 
                245                 250                 255     


His Ser Ser Pro Lys Arg Glu Leu Pro Pro Gly Ile Gly Asp Met Val 
            260                 265                 270         


Glu Leu Met Gly Val Gln Asp Gln His Met Asp Glu Arg Asp Val Arg 
        275                 280                 285             


Arg Phe Gln Leu Lys Ile Ala Glu Leu Asn Ser Val Ile Arg Lys Leu 
    290                 295                 300                 


Glu Asp Arg Asn Thr Leu Leu Ala Asp Glu Arg Asn Glu Leu Leu Lys 
305                 310                 315                 320 


Arg Ser Arg Glu Thr Glu Val Gln Leu Lys Pro Leu Val Glu Lys Asn 
                325                 330                 335     


Lys Arg Met Asn Lys Lys Asn Glu Asp Leu Leu Gln Ser Ile Gln Arg 
            340                 345                 350         


Met Glu Glu Lys Ile Lys Asn Leu Thr Arg Glu Asn Val Glu Met Lys 
        355                 360                 365             


Glu Lys Leu Ser Ala Gln Ala Ser Leu Lys Arg His Thr Ser Leu Asn 
    370                 375                 380                 


Asp Leu Ser Leu Thr Arg Asp Glu Gln Glu Ile Glu Phe Leu Arg Leu 
385                 390                 395                 400 


Gln Val Leu Glu Gln Gln His Val Ile Asp Asp Leu Ser Leu Glu Arg 
                405                 410                 415     


Glu Arg Leu Leu Arg Ser Lys Arg His Arg Gly Lys Ser Leu Lys Pro 
            420                 425                 430         


Pro Lys Lys His Val Val Glu Thr Phe Phe Gly Phe Asp Glu Glu Ser 
        435                 440                 445             


Val Asp Ser Glu Thr Leu Ser Glu Thr Ser Tyr Asn Thr Asp Arg Thr 
    450                 455                 460                 


Asp Arg Thr Pro Ala Thr Pro Glu Glu Asp Leu Asp Asp Ala Thr Ala 
465                 470                 475                 480 


Arg Glu Glu Ala Asp Leu Arg Phe Cys Gln Leu Thr Arg Glu Tyr Gln 
                485                 490                 495     


Ala Leu Gln Arg Ala Tyr Ala Leu Leu Gln Glu Gln Val Gly Gly Thr 
            500                 505                 510         


Leu Asp Ala Glu Arg Glu Ala Arg Thr Arg Glu Gln Leu Gln Ala Asp 
        515                 520                 525             


Leu Leu Arg Cys Gln Ala Lys Ile Glu Asp Leu Glu Lys Leu Leu Val 
    530                 535                 540                 


Glu Lys Gly Gln Asp Ser Lys Trp Val Glu Glu Lys Gln Leu Leu Ile 
545                 550                 555                 560 


Arg Thr Asn Gln Asp Leu Leu Glu Lys Ile Tyr Arg Leu Glu Met Glu 
                565                 570                 575     


Glu Asn Gln Leu Lys Asn Glu Met Gln Asp Ala Lys Asp Gln Asn Glu 
            580                 585                 590         


Leu Leu Glu Phe Arg Val Leu Glu Leu Glu Glu Arg Glu Arg Arg Ser 
        595                 600                 605             


Pro Ala Phe Asn Leu Gln Ile Thr Thr Phe Pro Glu Asn His Ser Ser 
    610                 615                 620                 


Ala Leu Gln Leu Phe Cys His Gln Glu Gly Val Lys Asp Val Asn Val 
625                 630                 635                 640 


Ser Glu Leu Met Lys Lys Leu Asp Ile Leu Gly Asp Asn Gly Asn Leu 
                645                 650                 655     


Arg Asn Glu Glu Gln Val Ala Ile Ile Gln Ala Gly Thr Val Leu Ala 
            660                 665                 670         


Leu Cys Glu Lys Trp Leu Lys Gln Ile Glu Gly Thr Glu Ala Ala Leu 
        675                 680                 685             


Thr Gln Lys Met Leu Asp Leu Glu Lys Glu Lys Asp Leu Phe Ser Arg 
    690                 695                 700                 


Gln Lys Gly Tyr Leu Glu Glu Glu Leu Asp Tyr Arg Lys Gln Ala Leu 
705                 710                 715                 720 


Asp Gln Ala Tyr Leu Lys Ile Gln Asp Leu Glu Ala Thr Leu Tyr Thr 
                725                 730                 735     


Ala Leu Gln Gln Glu Pro Gly Arg Arg Ala Gly Glu Ala Leu Ser Glu 
            740                 745                 750         


Gly Gln Arg Glu Asp Leu Gln Ala Ala Val Glu Lys Val Arg Arg Gln 
        755                 760                 765             


Ile Leu Arg Gln Ser Arg Glu Phe Asp Ser Gln Ile Leu Arg Glu Arg 
    770                 775                 780                 


Met Glu Leu Leu Gln Gln Ala Gln Gln Arg Ile Arg Glu Leu Glu Asp 
785                 790                 795                 800 


Lys Leu Glu Phe Gln Lys Arg His Leu Lys Glu Leu Glu Glu Lys Phe 
                805                 810                 815     


Leu Phe Leu Phe Leu Phe Phe Ser Leu Ala Phe Ile Leu Trp Pro 
            820                 825                 830     


<210>  425
<211>  646
<212>  PRT
<213>  Homo sapiens

<400>  425

Met Ser Lys Lys Gly Arg Ser Lys Gly Glu Lys Pro Glu Met Glu Thr 
1               5                   10                  15      


Asp Ala Val Gln Met Ala Asn Glu Glu Leu Arg Ala Lys Leu Thr Ser 
            20                  25                  30          


Ile Gln Ile Glu Phe Gln Gln Glu Lys Ser Lys Met Asp Glu Ile Lys 
        35                  40                  45              


Gly Lys Asp Arg Val Ile Leu Ala Leu Glu Lys Glu Leu Gly Val Gln 
    50                  55                  60                  


Ala Gly Gln Thr Gln Lys Leu Leu Leu Gln Lys Glu Ala Leu Asp Glu 
65                  70                  75                  80  


Gln Leu Val Gln Val Lys Glu Ala Glu Arg His His Ser Ser Pro Lys 
                85                  90                  95      


Arg Glu Leu Pro Pro Gly Ile Gly Asp Met Val Glu Leu Met Gly Val 
            100                 105                 110         


Gln Asp Gln His Met Asp Glu Arg Asp Val Arg Arg Phe Gln Leu Lys 
        115                 120                 125             


Ile Ala Glu Leu Asn Ser Val Ile Arg Lys Leu Glu Asp Arg Asn Thr 
    130                 135                 140                 


Leu Leu Ala Asp Glu Arg Asn Glu Leu Leu Lys Arg Ser Arg Glu Thr 
145                 150                 155                 160 


Glu Val Gln Leu Lys Pro Leu Val Glu Lys Asn Lys Arg Met Asn Lys 
                165                 170                 175     


Lys Asn Glu Asp Leu Leu Gln Ser Ile Gln Arg Met Glu Glu Lys Ile 
            180                 185                 190         


Lys Asn Leu Thr Arg Glu Asn Val Glu Met Lys Glu Lys Leu Ser Ala 
        195                 200                 205             


Gln Ala Ser Leu Lys Arg His Thr Ser Leu Asn Asp Leu Ser Leu Thr 
    210                 215                 220                 


Arg Asp Glu Gln Glu Ile Glu Phe Leu Arg Leu Gln Val Leu Glu Gln 
225                 230                 235                 240 


Gln His Val Ile Asp Asp Leu Ser Leu Lys His Val Val Glu Thr Phe 
                245                 250                 255     


Phe Gly Phe Asp Glu Glu Ser Val Asp Ser Glu Thr Leu Ser Glu Thr 
            260                 265                 270         


Ser Tyr Asn Thr Asp Arg Thr Asp Arg Thr Pro Ala Thr Pro Glu Glu 
        275                 280                 285             


Asp Leu Asp Asp Ala Thr Ala Arg Glu Glu Ala Asp Leu Arg Phe Cys 
    290                 295                 300                 


Gln Leu Thr Arg Glu Tyr Gln Ala Leu Gln Arg Ala Tyr Ala Leu Leu 
305                 310                 315                 320 


Gln Glu Gln Val Gly Gly Thr Leu Asp Ala Glu Arg Glu Ala Arg Thr 
                325                 330                 335     


Arg Glu Gln Leu Gln Ala Asp Leu Leu Arg Cys Gln Ala Lys Ile Glu 
            340                 345                 350         


Asp Leu Glu Lys Leu Leu Val Glu Lys Gly Gln Asp Ser Lys Trp Val 
        355                 360                 365             


Glu Glu Lys Gln Leu Leu Ile Arg Thr Asn Gln Asp Leu Leu Glu Lys 
    370                 375                 380                 


Ile Tyr Arg Leu Glu Met Glu Glu Asn Gln Leu Lys Asn Glu Met Gln 
385                 390                 395                 400 


Asp Ala Lys Asp Gln Asn Glu Leu Leu Glu Phe Arg Val Leu Glu Leu 
                405                 410                 415     


Glu Glu Arg Glu Arg Arg Ser Pro Ala Phe Asn Leu Gln Ile Thr Thr 
            420                 425                 430         


Phe Pro Glu Asn His Ser Ser Ala Leu Gln Leu Phe Cys His Gln Glu 
        435                 440                 445             


Gly Val Lys Asp Val Asn Val Ser Glu Leu Met Lys Lys Leu Asp Ile 
    450                 455                 460                 


Leu Gly Asp Asn Gly Asn Leu Arg Asn Glu Glu Gln Val Ala Ile Ile 
465                 470                 475                 480 


Gln Ala Gly Thr Val Leu Ala Leu Cys Glu Lys Trp Leu Lys Gln Ile 
                485                 490                 495     


Glu Gly Thr Glu Ala Ala Leu Thr Gln Lys Met Leu Asp Leu Glu Lys 
            500                 505                 510         


Glu Lys Asp Leu Phe Ser Arg Gln Lys Gly Tyr Leu Glu Glu Glu Leu 
        515                 520                 525             


Asp Tyr Arg Lys Gln Ala Leu Asp Gln Ala Tyr Leu Lys Ile Gln Asp 
    530                 535                 540                 


Leu Glu Ala Thr Leu Tyr Thr Ala Leu Gln Gln Glu Pro Gly Arg Arg 
545                 550                 555                 560 


Ala Gly Glu Ala Leu Ser Glu Gly Gln Arg Glu Asp Leu Gln Ala Ala 
                565                 570                 575     


Val Glu Lys Val Arg Arg Gln Ile Leu Arg Gln Ser Arg Glu Phe Asp 
            580                 585                 590         


Ser Gln Ile Leu Arg Glu Arg Met Glu Leu Leu Gln Gln Ala Gln Gln 
        595                 600                 605             


Arg Ile Arg Glu Leu Glu Asp Lys Leu Glu Phe Gln Lys Arg His Leu 
    610                 615                 620                 


Lys Glu Leu Glu Glu Lys Phe Leu Phe Leu Phe Leu Phe Phe Ser Leu 
625                 630                 635                 640 


Ala Phe Ile Leu Trp Pro 
                645     


<210>  426
<211>  66
<212>  PRT
<213>  Homo sapiens

<400>  426

Met Ala Ala Ile Arg Lys Lys Leu Val Ile Val Gly Asp Gly Ala Cys 
1               5                   10                  15      


Gly Lys Thr Cys Leu Leu Ile Val Phe Ser Lys Asp Gln Phe Pro Glu 
            20                  25                  30          


Val Tyr Val Pro Thr Val Phe Glu Asn Tyr Ile Ala Asp Ile Glu Val 
        35                  40                  45              


Asp Gly Lys Gln Thr Gly Ser Val Thr Trp Ala Glu Ser Leu Cys Leu 
    50                  55                  60                  


Trp Val 
65      


<210>  427
<211>  66
<212>  PRT
<213>  Homo sapiens

<400>  427

Met Ala Ala Ile Arg Lys Lys Leu Val Ile Val Gly Asp Gly Ala Cys 
1               5                   10                  15      


Gly Lys Thr Cys Leu Leu Ile Val Phe Ser Lys Asp Gln Phe Pro Glu 
            20                  25                  30          


Val Tyr Val Pro Thr Val Phe Glu Asn Tyr Ile Ala Asp Ile Glu Val 
        35                  40                  45              


Asp Gly Lys Gln Thr Gly Ser Val Thr Trp Ala Glu Ser Leu Cys Leu 
    50                  55                  60                  


Trp Val 
65      


<210>  428
<211>  66
<212>  PRT
<213>  Homo sapiens

<400>  428

Met Ala Ala Ile Arg Lys Lys Leu Val Ile Val Gly Asp Gly Ala Cys 
1               5                   10                  15      


Gly Lys Thr Cys Leu Leu Ile Val Phe Ser Lys Asp Gln Phe Pro Glu 
            20                  25                  30          


Val Tyr Val Pro Thr Val Phe Glu Asn Tyr Ile Ala Asp Ile Glu Val 
        35                  40                  45              


Asp Gly Lys Gln Thr Gly Ser Val Thr Trp Ala Glu Ser Leu Cys Leu 
    50                  55                  60                  


Trp Val 
65      


<210>  429
<211>  500
<212>  PRT
<213>  Homo sapiens

<400>  429

Met Pro Pro Ala Val Gly Gly Pro Val Gly Tyr Thr Pro Pro Asp Gly 
1               5                   10                  15      


Gly Trp Gly Trp Ala Val Val Ile Gly Ala Phe Ile Ser Ile Gly Phe 
            20                  25                  30          


Ser Tyr Ala Phe Pro Lys Ser Ile Thr Val Phe Phe Lys Glu Ile Glu 
        35                  40                  45              


Gly Ile Phe His Ala Thr Thr Ser Glu Val Ser Trp Ile Ser Ser Ile 
    50                  55                  60                  


Met Leu Ala Val Met Tyr Gly Gly Gly Pro Ile Ser Ser Ile Leu Val 
65                  70                  75                  80  


Asn Lys Tyr Gly Ser Arg Ile Val Met Ile Val Gly Gly Cys Leu Ser 
                85                  90                  95      


Gly Cys Gly Leu Ile Ala Ala Ser Phe Cys Asn Thr Val Gln Gln Leu 
            100                 105                 110         


Tyr Val Cys Ile Gly Val Ile Gly Gly Leu Gly Leu Ala Phe Asn Leu 
        115                 120                 125             


Asn Pro Ala Leu Thr Met Ile Gly Lys Tyr Phe Tyr Lys Arg Arg Pro 
    130                 135                 140                 


Leu Ala Asn Gly Leu Ala Met Ala Gly Ser Pro Val Phe Leu Cys Thr 
145                 150                 155                 160 


Leu Ala Pro Leu Asn Gln Val Phe Phe Gly Ile Phe Gly Trp Arg Gly 
                165                 170                 175     


Ser Phe Leu Ile Leu Gly Gly Leu Leu Leu Asn Cys Cys Val Ala Gly 
            180                 185                 190         


Ala Leu Met Arg Pro Ile Gly Pro Lys Pro Thr Lys Ala Gly Lys Asp 
        195                 200                 205             


Lys Ser Lys Ala Ser Leu Glu Lys Ala Gly Lys Ser Gly Val Lys Lys 
    210                 215                 220                 


Asp Leu His Asp Ala Asn Thr Asp Leu Ile Gly Arg His Pro Lys Gln 
225                 230                 235                 240 


Glu Lys Arg Ser Val Phe Gln Thr Ile Asn Gln Phe Leu Asp Leu Thr 
                245                 250                 255     


Leu Phe Thr His Arg Gly Phe Leu Leu Tyr Leu Ser Gly Asn Val Ile 
            260                 265                 270         


Met Phe Phe Gly Leu Phe Ala Pro Leu Val Phe Leu Ser Ser Tyr Gly 
        275                 280                 285             


Lys Ser Gln His Tyr Ser Ser Glu Lys Ser Ala Phe Leu Leu Ser Ile 
    290                 295                 300                 


Leu Ala Phe Val Asp Met Val Ala Arg Pro Ser Met Gly Leu Val Ala 
305                 310                 315                 320 


Asn Thr Lys Pro Ile Arg Pro Arg Ile Gln Tyr Phe Phe Ala Ala Ser 
                325                 330                 335     


Val Val Ala Asn Gly Val Cys His Met Leu Ala Pro Leu Ser Thr Thr 
            340                 345                 350         


Tyr Val Gly Phe Cys Val Tyr Ala Gly Phe Phe Gly Phe Ala Phe Gly 
        355                 360                 365             


Trp Leu Ser Ser Val Leu Phe Glu Thr Leu Met Asp Leu Val Gly Pro 
    370                 375                 380                 


Gln Arg Phe Ser Ser Ala Val Gly Leu Val Thr Ile Val Glu Cys Cys 
385                 390                 395                 400 


Pro Val Leu Leu Gly Pro Pro Leu Leu Gly Arg Leu Asn Asp Met Tyr 
                405                 410                 415     


Gly Asp Tyr Lys Tyr Thr Tyr Trp Ala Cys Gly Val Val Leu Ile Ile 
            420                 425                 430         


Ser Gly Ile Tyr Leu Phe Ile Gly Met Gly Ile Asn Tyr Arg Leu Leu 
        435                 440                 445             


Ala Lys Glu Gln Lys Ala Asn Glu Gln Lys Lys Glu Ser Lys Glu Glu 
    450                 455                 460                 


Glu Thr Ser Ile Asp Val Ala Gly Lys Pro Asn Glu Val Thr Lys Ala 
465                 470                 475                 480 


Ala Glu Ser Pro Asp Gln Lys Asp Thr Asp Gly Gly Pro Lys Glu Glu 
                485                 490                 495     


Glu Ser Pro Val 
            500 


<210>  430
<211>  215
<212>  PRT
<213>  Homo sapiens

<400>  430

Met Pro Pro Ala Val Gly Gly Pro Val Gly Tyr Thr Pro Pro Asp Gly 
1               5                   10                  15      


Gly Trp Gly Trp Ala Val Val Ile Gly Ala Phe Ile Ser Ile Gly Phe 
            20                  25                  30          


Ser Tyr Ala Phe Pro Lys Ser Ile Thr Val Phe Phe Lys Glu Ile Glu 
        35                  40                  45              


Gly Ile Phe His Ala Thr Thr Ser Glu Val Ser Trp Ile Ser Ser Ile 
    50                  55                  60                  


Met Leu Ala Val Met Tyr Gly Gly Gly Pro Ile Ser Ser Ile Leu Val 
65                  70                  75                  80  


Asn Lys Tyr Gly Ser Arg Ile Val Met Ile Val Gly Gly Cys Leu Ser 
                85                  90                  95      


Gly Cys Gly Leu Ile Ala Ala Ser Phe Cys Asn Thr Val Gln Gln Leu 
            100                 105                 110         


Tyr Val Cys Ile Gly Val Ile Gly Gly Leu Gly Leu Ala Phe Asn Leu 
        115                 120                 125             


Asn Pro Ala Leu Thr Met Ile Gly Lys Tyr Phe Tyr Lys Arg Arg Pro 
    130                 135                 140                 


Leu Ala Asn Gly Leu Ala Met Ala Gly Ser Pro Val Phe Leu Cys Thr 
145                 150                 155                 160 


Leu Ala Pro Leu Asn Gln Val Phe Phe Gly Ile Phe Gly Trp Arg Gly 
                165                 170                 175     


Ser Phe Leu Ile Leu Gly Gly Leu Leu Leu Asn Cys Cys Val Ala Gly 
            180                 185                 190         


Ala Leu Met Arg Pro Ile Gly Pro Lys Pro Thr Lys Ala Gly Lys Asp 
        195                 200                 205             


Lys Ser Lys Ala Ser Leu Glu 
    210                 215 


<210>  431
<211>  296
<212>  PRT
<213>  Homo sapiens

<400>  431

Met Pro Pro Ala Val Gly Gly Pro Val Gly Tyr Thr Pro Pro Asp Gly 
1               5                   10                  15      


Gly Trp Gly Trp Ala Val Val Ile Gly Ala Phe Ile Ser Ile Gly Phe 
            20                  25                  30          


Ser Tyr Ala Phe Pro Lys Ser Ile Thr Val Phe Phe Lys Glu Ile Glu 
        35                  40                  45              


Gly Ile Phe His Ala Thr Thr Ser Glu Val Ser Trp Ile Ser Ser Ile 
    50                  55                  60                  


Met Leu Ala Val Met Tyr Gly Gly Gly Pro Ile Ser Ser Ile Leu Val 
65                  70                  75                  80  


Asn Lys Tyr Gly Ser Arg Ile Val Met Ile Val Gly Gly Cys Leu Ser 
                85                  90                  95      


Gly Cys Gly Leu Ile Ala Ala Ser Phe Cys Asn Thr Val Gln Gln Leu 
            100                 105                 110         


Tyr Val Cys Ile Gly Val Ile Gly Gly Leu Gly Leu Ala Phe Asn Leu 
        115                 120                 125             


Asn Pro Ala Leu Thr Met Ile Gly Lys Tyr Phe Tyr Lys Arg Arg Pro 
    130                 135                 140                 


Leu Ala Asn Gly Leu Ala Met Ala Gly Ser Pro Val Phe Leu Cys Thr 
145                 150                 155                 160 


Leu Ala Pro Leu Asn Gln Val Phe Phe Gly Ile Phe Gly Trp Arg Gly 
                165                 170                 175     


Ser Phe Leu Ile Leu Gly Gly Leu Leu Leu Asn Cys Cys Val Ala Gly 
            180                 185                 190         


Ala Leu Met Arg Pro Ile Gly Pro Lys Pro Thr Lys Ala Gly Lys Asp 
        195                 200                 205             


Lys Ser Lys Ala Ser Leu Glu Lys Ala Gly Lys Ser Gly Val Lys Lys 
    210                 215                 220                 


Asp Leu His Asp Ala Asn Thr Asp Leu Ile Gly Arg His Pro Lys Gln 
225                 230                 235                 240 


Glu Lys Arg Ser Val Phe Gln Thr Ile Asn Gln Phe Leu Asp Leu Thr 
                245                 250                 255     


Leu Phe Thr His Arg Gly Phe Leu Leu Tyr Leu Ser Gly Asn Val Ile 
            260                 265                 270         


Met Phe Phe Gly Leu Phe Ala Pro Leu Val Phe Leu Ser Ser Tyr Gly 
        275                 280                 285             


Lys Ser Gln His Tyr Ser Ser Glu 
    290                 295     


<210>  432
<211>  456
<212>  PRT
<213>  Homo sapiens

<400>  432

Met Pro Pro Ala Val Gly Gly Pro Val Gly Tyr Thr Pro Pro Asp Gly 
1               5                   10                  15      


Gly Trp Gly Trp Ala Val Val Ile Gly Ala Phe Ile Ser Ile Gly Phe 
            20                  25                  30          


Ser Tyr Ala Phe Pro Lys Ser Ile Thr Val Phe Phe Lys Glu Ile Glu 
        35                  40                  45              


Gly Ile Phe His Ala Thr Thr Ser Glu Val Ser Trp Ile Ser Ser Ile 
    50                  55                  60                  


Met Leu Ala Val Met Tyr Gly Gly Gly Pro Ile Ser Ser Ile Leu Val 
65                  70                  75                  80  


Asn Lys Tyr Gly Ser Arg Ile Val Met Ile Val Gly Gly Cys Leu Ser 
                85                  90                  95      


Gly Cys Gly Leu Ile Ala Ala Ser Phe Cys Asn Thr Val Gln Gln Leu 
            100                 105                 110         


Tyr Val Cys Ile Gly Val Ile Gly Gly Leu Gly Leu Ala Phe Asn Leu 
        115                 120                 125             


Asn Pro Ala Leu Thr Met Ile Gly Lys Tyr Phe Tyr Lys Arg Arg Pro 
    130                 135                 140                 


Leu Ala Asn Gly Leu Ala Met Ala Gly Ser Pro Val Phe Leu Cys Thr 
145                 150                 155                 160 


Leu Ala Pro Leu Asn Gln Val Phe Phe Gly Ile Phe Gly Trp Arg Gly 
                165                 170                 175     


Ser Phe Leu Ile Leu Gly Gly Leu Leu Leu Asn Cys Cys Val Ala Gly 
            180                 185                 190         


Ala Leu Met Arg Pro Ile Gly Pro Lys Pro Thr Lys Ala Gly Lys Asp 
        195                 200                 205             


Lys Ser Lys Ala Ser Leu Glu Lys Ala Gly Lys Ser Gly Val Lys Lys 
    210                 215                 220                 


Asp Leu His Asp Ala Asn Thr Asp Leu Ile Gly Arg His Pro Lys Gln 
225                 230                 235                 240 


Glu Lys Arg Ser Val Phe Gln Thr Ile Asn Gln Phe Leu Asp Leu Thr 
                245                 250                 255     


Leu Phe Thr His Arg Gly Phe Leu Leu Tyr Leu Ser Gly Asn Val Ile 
            260                 265                 270         


Met Phe Phe Gly Leu Phe Ala Pro Leu Val Phe Leu Ser Ser Tyr Gly 
        275                 280                 285             


Lys Ser Gln His Tyr Ser Ser Glu Lys Ser Ala Phe Leu Leu Ser Ile 
    290                 295                 300                 


Leu Ala Phe Val Asp Met Val Ala Arg Pro Ser Met Gly Leu Val Ala 
305                 310                 315                 320 


Asn Thr Lys Pro Ile Arg Pro Arg Ile Gln Tyr Phe Phe Ala Ala Ser 
                325                 330                 335     


Val Val Ala Asn Gly Val Cys His Met Leu Ala Pro Leu Ser Thr Thr 
            340                 345                 350         


Tyr Val Gly Phe Cys Val Tyr Ala Gly Phe Phe Gly Phe Ala Phe Gly 
        355                 360                 365             


Trp Leu Ser Ser Val Leu Phe Glu Thr Leu Met Asp Leu Val Gly Pro 
    370                 375                 380                 


Gln Arg Phe Ser Ser Ala Val Gly Leu Val Thr Ile Val Glu Cys Cys 
385                 390                 395                 400 


Pro Val Leu Leu Gly Pro Pro Leu Leu Gly Arg Leu Asn Asp Met Tyr 
                405                 410                 415     


Gly Asp Tyr Lys Tyr Thr Tyr Trp Ala Cys Gly Val Val Leu Ile Ile 
            420                 425                 430         


Ser Gly Ile Tyr Leu Phe Ile Gly Met Gly Ile Asn Tyr Arg Leu Leu 
        435                 440                 445             


Ala Lys Glu Gln Lys Ala Asn Glu 
    450                 455     


<210>  433
<211>  500
<212>  PRT
<213>  Homo sapiens

<400>  433

Met Pro Pro Ala Val Gly Gly Pro Val Gly Tyr Thr Pro Pro Asp Gly 
1               5                   10                  15      


Gly Trp Gly Trp Ala Val Val Ile Gly Ala Phe Ile Ser Ile Gly Phe 
            20                  25                  30          


Ser Tyr Ala Phe Pro Lys Ser Ile Thr Val Phe Phe Lys Glu Ile Glu 
        35                  40                  45              


Gly Ile Phe His Ala Thr Thr Ser Glu Val Ser Trp Ile Ser Ser Ile 
    50                  55                  60                  


Met Leu Ala Val Met Tyr Gly Gly Gly Pro Ile Ser Ser Ile Leu Val 
65                  70                  75                  80  


Asn Lys Tyr Gly Ser Arg Ile Val Met Ile Val Gly Gly Cys Leu Ser 
                85                  90                  95      


Gly Cys Gly Leu Ile Ala Ala Ser Phe Cys Asn Thr Val Gln Gln Leu 
            100                 105                 110         


Tyr Val Cys Ile Gly Val Ile Gly Gly Leu Gly Leu Ala Phe Asn Leu 
        115                 120                 125             


Asn Pro Ala Leu Thr Met Ile Gly Lys Tyr Phe Tyr Lys Arg Arg Pro 
    130                 135                 140                 


Leu Ala Asn Gly Leu Ala Met Ala Gly Ser Pro Val Phe Leu Cys Thr 
145                 150                 155                 160 


Leu Ala Pro Leu Asn Gln Val Phe Phe Gly Ile Phe Gly Trp Arg Gly 
                165                 170                 175     


Ser Phe Leu Ile Leu Gly Gly Leu Leu Leu Asn Cys Cys Val Ala Gly 
            180                 185                 190         


Ala Leu Met Arg Pro Ile Gly Pro Lys Pro Thr Lys Ala Gly Lys Asp 
        195                 200                 205             


Lys Ser Lys Ala Ser Leu Glu Lys Ala Gly Lys Ser Gly Val Lys Lys 
    210                 215                 220                 


Asp Leu His Asp Ala Asn Thr Asp Leu Ile Gly Arg His Pro Lys Gln 
225                 230                 235                 240 


Glu Lys Arg Ser Val Phe Gln Thr Ile Asn Gln Phe Leu Asp Leu Thr 
                245                 250                 255     


Leu Phe Thr His Arg Gly Phe Leu Leu Tyr Leu Ser Gly Asn Val Ile 
            260                 265                 270         


Met Phe Phe Gly Leu Phe Ala Pro Leu Val Phe Leu Ser Ser Tyr Gly 
        275                 280                 285             


Lys Ser Gln His Tyr Ser Ser Glu Lys Ser Ala Phe Leu Leu Ser Ile 
    290                 295                 300                 


Leu Ala Phe Val Asp Met Val Ala Arg Pro Ser Met Gly Leu Val Ala 
305                 310                 315                 320 


Asn Thr Lys Pro Ile Arg Pro Arg Ile Gln Tyr Phe Phe Ala Ala Ser 
                325                 330                 335     


Val Val Ala Asn Gly Val Cys His Met Leu Ala Pro Leu Ser Thr Thr 
            340                 345                 350         


Tyr Val Gly Phe Cys Val Tyr Ala Gly Phe Phe Gly Phe Ala Phe Gly 
        355                 360                 365             


Trp Leu Ser Ser Val Leu Phe Glu Thr Leu Met Asp Leu Val Gly Pro 
    370                 375                 380                 


Gln Arg Phe Ser Ser Ala Val Gly Leu Val Thr Ile Val Glu Cys Cys 
385                 390                 395                 400 


Pro Val Leu Leu Gly Pro Pro Leu Leu Gly Arg Leu Asn Asp Met Tyr 
                405                 410                 415     


Gly Asp Tyr Lys Tyr Thr Tyr Trp Ala Cys Gly Val Val Leu Ile Ile 
            420                 425                 430         


Ser Gly Ile Tyr Leu Phe Ile Gly Met Gly Ile Asn Tyr Arg Leu Leu 
        435                 440                 445             


Ala Lys Glu Gln Lys Ala Asn Glu Gln Lys Lys Glu Ser Lys Glu Glu 
    450                 455                 460                 


Glu Thr Ser Ile Asp Val Ala Gly Lys Pro Asn Glu Val Thr Lys Ala 
465                 470                 475                 480 


Ala Glu Ser Pro Asp Gln Lys Asp Thr Asp Gly Gly Pro Lys Glu Glu 
                485                 490                 495     


Glu Ser Pro Val 
            500 


<210>  434
<211>  109
<212>  PRT
<213>  Homo sapiens

<400>  434

Met Lys Phe Ile Ser Thr Ser Leu Leu Leu Met Leu Leu Val Ser Ser 
1               5                   10                  15      


Leu Ser Pro Val Gln Gly Val Leu Glu Val Tyr Tyr Thr Ser Leu Arg 
            20                  25                  30          


Cys Arg Cys Val Gln Glu Ser Ser Val Phe Ile Pro Arg Arg Phe Ile 
        35                  40                  45              


Asp Arg Ile Gln Ile Leu Pro Arg Gly Asn Gly Cys Pro Arg Lys Glu 
    50                  55                  60                  


Ile Ile Val Trp Lys Lys Asn Lys Ser Ile Val Cys Val Asp Pro Gln 
65                  70                  75                  80  


Ala Glu Trp Ile Gln Arg Met Met Glu Val Leu Arg Lys Arg Ser Ser 
                85                  90                  95      


Ser Thr Leu Pro Val Pro Val Phe Lys Arg Lys Ile Pro 
            100                 105                 


<210>  435
<211>  729
<212>  PRT
<213>  Homo sapiens

<400>  435

Met Asp Asp Leu Thr Leu Leu Asp Leu Leu Glu Cys Pro Val Cys Phe 
1               5                   10                  15      


Glu Lys Leu Asp Val Thr Ala Lys Val Leu Pro Cys Gln His Thr Phe 
            20                  25                  30          


Cys Lys Pro Cys Leu Gln Arg Val Phe Lys Ala His Lys Glu Leu Arg 
        35                  40                  45              


Cys Pro Glu Cys Arg Thr Pro Val Phe Ser Asn Ile Glu Ala Leu Pro 
    50                  55                  60                  


Ala Asn Leu Leu Leu Val Arg Leu Leu Asp Gly Val Arg Ser Gly Gln 
65                  70                  75                  80  


Ser Ser Gly Arg Gly Gly Ser Phe Arg Arg Pro Gly Thr Met Thr Leu 
                85                  90                  95      


Gln Asp Gly Arg Lys Ser Arg Thr Asn Pro Arg Arg Leu Gln Ala Ser 
            100                 105                 110         


Pro Phe Arg Leu Val Pro Asn Val Arg Ile His Met Asp Gly Val Pro 
        115                 120                 125             


Arg Ala Lys Ala Leu Cys Asn Tyr Arg Gly Gln Asn Pro Gly Asp Leu 
    130                 135                 140                 


Arg Phe Asn Lys Gly Asp Ile Ile Leu Leu Arg Arg Gln Leu Asp Glu 
145                 150                 155                 160 


Asn Trp Tyr Gln Gly Glu Ile Asn Gly Ile Ser Gly Asn Phe Pro Ala 
                165                 170                 175     


Ser Ser Val Glu Val Ile Lys Gln Leu Pro Gln Pro Pro Pro Leu Cys 
            180                 185                 190         


Arg Ala Leu Tyr Asn Phe Asp Leu Arg Gly Lys Asp Lys Ser Glu Asn 
        195                 200                 205             


Gln Asp Cys Leu Thr Phe Leu Lys Asp Asp Ile Ile Thr Val Ile Ser 
    210                 215                 220                 


Arg Val Asp Glu Asn Trp Ala Glu Gly Lys Leu Gly Asp Lys Val Gly 
225                 230                 235                 240 


Ile Phe Pro Ile Leu Phe Val Glu Pro Asn Leu Thr Ala Arg His Leu 
                245                 250                 255     


Leu Glu Lys Asn Lys Gly Arg Gln Ser Ser Arg Thr Lys Asn Leu Ser 
            260                 265                 270         


Leu Val Ser Ser Ser Ser Arg Gly Asn Thr Ser Thr Leu Arg Arg Gly 
        275                 280                 285             


Pro Gly Ser Arg Arg Lys Val Pro Gly Gln Phe Ser Ile Thr Thr Ala 
    290                 295                 300                 


Leu Asn Thr Leu Asn Arg Met Val His Ser Pro Ser Gly Arg His Met 
305                 310                 315                 320 


Val Glu Ile Ser Thr Pro Val Leu Ile Ser Ser Ser Asn Pro Ser Val 
                325                 330                 335     


Ile Thr Gln Pro Met Glu Lys Ala Asp Val Pro Ser Ser Cys Val Gly 
            340                 345                 350         


Gln Val Ser Thr Tyr His Pro Ala Pro Val Ser Pro Gly His Ser Thr 
        355                 360                 365             


Ala Val Val Ser Leu Pro Gly Ser Gln Gln His Leu Ser Ala Asn Met 
    370                 375                 380                 


Phe Val Ala Leu His Ser Tyr Ser Ala His Gly Pro Asp Glu Leu Asp 
385                 390                 395                 400 


Leu Gln Lys Gly Glu Gly Val Arg Val Leu Gly Lys Cys Gln Asp Gly 
                405                 410                 415     


Trp Leu Arg Gly Val Ser Leu Val Thr Gly Arg Val Gly Ile Phe Pro 
            420                 425                 430         


Asn Asn Tyr Val Ile Pro Ile Phe Arg Lys Thr Ser Ser Phe Pro Asp 
        435                 440                 445             


Ser Arg Ser Pro Gly Leu Tyr Thr Thr Trp Thr Leu Ser Thr Ser Ser 
    450                 455                 460                 


Val Ser Ser Gln Gly Ser Ile Ser Glu Gly Asp Pro Arg Gln Ser Arg 
465                 470                 475                 480 


Pro Phe Lys Ser Val Phe Val Pro Thr Ala Ile Val Asn Pro Val Arg 
                485                 490                 495     


Ser Thr Ala Gly Pro Gly Thr Leu Gly Gln Gly Ser Leu Arg Lys Gly 
            500                 505                 510         


Arg Ser Ser Met Arg Lys Asn Gly Ser Leu Gln Arg Pro Leu Gln Ser 
        515                 520                 525             


Gly Ile Pro Thr Leu Val Val Gly Ser Leu Arg Arg Ser Pro Thr Met 
    530                 535                 540                 


Val Leu Arg Pro Gln Gln Phe Gln Phe Tyr Gln Pro Gln Gly Ile Pro 
545                 550                 555                 560 


Ser Ser Pro Ser Ala Val Val Val Glu Met Gly Ser Lys Pro Ala Leu 
                565                 570                 575     


Thr Gly Glu Pro Ala Leu Thr Cys Ile Ser Arg Gly Ser Glu Ala Trp 
            580                 585                 590         


Ile His Ser Ala Ala Ser Ser Leu Ile Met Glu Asp Lys Glu Ile Pro 
        595                 600                 605             


Ile Lys Ser Glu Pro Leu Pro Lys Pro Pro Ala Ser Ala Pro Pro Ser 
    610                 615                 620                 


Ile Leu Val Lys Pro Glu Asn Ser Arg Asn Gly Ile Glu Lys Gln Val 
625                 630                 635                 640 


Lys Thr Val Arg Phe Gln Asn Tyr Ser Pro Pro Pro Thr Lys His Tyr 
                645                 650                 655     


Thr Ser His Pro Thr Ser Gly Lys Pro Glu Gln Pro Ala Thr Leu Lys 
            660                 665                 670         


Ala Ser Gln Pro Glu Ala Ala Ser Leu Gly Pro Glu Met Thr Val Leu 
        675                 680                 685             


Phe Ala His Arg Ser Gly Cys His Ser Gly Gln Gln Thr Asp Leu Arg 
    690                 695                 700                 


Arg Lys Ser Ala Leu Gly Lys Ala Thr Thr Leu Val Ser Thr Ala Ser 
705                 710                 715                 720 


Gly Thr Gln Thr Val Phe Pro Ser Lys 
                725                 


<210>  436
<211>  729
<212>  PRT
<213>  Homo sapiens

<400>  436

Met Asp Asp Leu Thr Leu Leu Asp Leu Leu Glu Cys Pro Val Cys Phe 
1               5                   10                  15      


Glu Lys Leu Asp Val Thr Ala Lys Val Leu Pro Cys Gln His Thr Phe 
            20                  25                  30          


Cys Lys Pro Cys Leu Gln Arg Val Phe Lys Ala His Lys Glu Leu Arg 
        35                  40                  45              


Cys Pro Glu Cys Arg Thr Pro Val Phe Ser Asn Ile Glu Ala Leu Pro 
    50                  55                  60                  


Ala Asn Leu Leu Leu Val Arg Leu Leu Asp Gly Val Arg Ser Gly Gln 
65                  70                  75                  80  


Ser Ser Gly Arg Gly Gly Ser Phe Arg Arg Pro Gly Thr Met Thr Leu 
                85                  90                  95      


Gln Asp Gly Arg Lys Ser Arg Thr Asn Pro Arg Arg Leu Gln Ala Ser 
            100                 105                 110         


Pro Phe Arg Leu Val Pro Asn Val Arg Ile His Met Asp Gly Val Pro 
        115                 120                 125             


Arg Ala Lys Ala Leu Cys Asn Tyr Arg Gly Gln Asn Pro Gly Asp Leu 
    130                 135                 140                 


Arg Phe Asn Lys Gly Asp Ile Ile Leu Leu Arg Arg Gln Leu Asp Glu 
145                 150                 155                 160 


Asn Trp Tyr Gln Gly Glu Ile Asn Gly Ile Ser Gly Asn Phe Pro Ala 
                165                 170                 175     


Ser Ser Val Glu Val Ile Lys Gln Leu Pro Gln Pro Pro Pro Leu Cys 
            180                 185                 190         


Arg Ala Leu Tyr Asn Phe Asp Leu Arg Gly Lys Asp Lys Ser Glu Asn 
        195                 200                 205             


Gln Asp Cys Leu Thr Phe Leu Lys Asp Asp Ile Ile Thr Val Ile Ser 
    210                 215                 220                 


Arg Val Asp Glu Asn Trp Ala Glu Gly Lys Leu Gly Asp Lys Val Gly 
225                 230                 235                 240 


Ile Phe Pro Ile Leu Phe Val Glu Pro Asn Leu Thr Ala Arg His Leu 
                245                 250                 255     


Leu Glu Lys Asn Lys Gly Arg Gln Ser Ser Arg Thr Lys Asn Leu Ser 
            260                 265                 270         


Leu Val Ser Ser Ser Ser Arg Gly Asn Thr Ser Thr Leu Arg Arg Gly 
        275                 280                 285             


Pro Gly Ser Arg Arg Lys Val Pro Gly Gln Phe Ser Ile Thr Thr Ala 
    290                 295                 300                 


Leu Asn Thr Leu Asn Arg Met Val His Ser Pro Ser Gly Arg His Met 
305                 310                 315                 320 


Val Glu Ile Ser Thr Pro Val Leu Ile Ser Ser Ser Asn Pro Ser Val 
                325                 330                 335     


Ile Thr Gln Pro Met Glu Lys Ala Asp Val Pro Ser Ser Cys Val Gly 
            340                 345                 350         


Gln Val Ser Thr Tyr His Pro Ala Pro Val Ser Pro Gly His Ser Thr 
        355                 360                 365             


Ala Val Val Ser Leu Pro Gly Ser Gln Gln His Leu Ser Ala Asn Met 
    370                 375                 380                 


Phe Val Ala Leu His Ser Tyr Ser Ala His Gly Pro Asp Glu Leu Asp 
385                 390                 395                 400 


Leu Gln Lys Gly Glu Gly Val Arg Val Leu Gly Lys Cys Gln Asp Gly 
                405                 410                 415     


Trp Leu Arg Gly Val Ser Leu Val Thr Gly Arg Val Gly Ile Phe Pro 
            420                 425                 430         


Asn Asn Tyr Val Ile Pro Ile Phe Arg Lys Thr Ser Ser Phe Pro Asp 
        435                 440                 445             


Ser Arg Ser Pro Gly Leu Tyr Thr Thr Trp Thr Leu Ser Thr Ser Ser 
    450                 455                 460                 


Val Ser Ser Gln Gly Ser Ile Ser Glu Gly Asp Pro Arg Gln Ser Arg 
465                 470                 475                 480 


Pro Phe Lys Ser Val Phe Val Pro Thr Ala Ile Val Asn Pro Val Arg 
                485                 490                 495     


Ser Thr Ala Gly Pro Gly Thr Leu Gly Gln Gly Ser Leu Arg Lys Gly 
            500                 505                 510         


Arg Ser Ser Met Arg Lys Asn Gly Ser Leu Gln Arg Pro Leu Gln Ser 
        515                 520                 525             


Gly Ile Pro Thr Leu Val Val Gly Ser Leu Arg Arg Ser Pro Thr Met 
    530                 535                 540                 


Val Leu Arg Pro Gln Gln Phe Gln Phe Tyr Gln Pro Gln Gly Ile Pro 
545                 550                 555                 560 


Ser Ser Pro Ser Ala Val Val Val Glu Met Gly Ser Lys Pro Ala Leu 
                565                 570                 575     


Thr Gly Glu Pro Ala Leu Thr Cys Ile Ser Arg Gly Ser Glu Ala Trp 
            580                 585                 590         


Ile His Ser Ala Ala Ser Ser Leu Ile Met Glu Asp Lys Glu Ile Pro 
        595                 600                 605             


Ile Lys Ser Glu Pro Leu Pro Lys Pro Pro Ala Ser Ala Pro Pro Ser 
    610                 615                 620                 


Ile Leu Val Lys Pro Glu Asn Ser Arg Asn Gly Ile Glu Lys Gln Val 
625                 630                 635                 640 


Lys Thr Val Arg Phe Gln Asn Tyr Ser Pro Pro Pro Thr Lys His Tyr 
                645                 650                 655     


Thr Ser His Pro Thr Ser Gly Lys Pro Glu Gln Pro Ala Thr Leu Lys 
            660                 665                 670         


Ala Ser Gln Pro Glu Ala Ala Ser Leu Gly Pro Glu Met Thr Val Leu 
        675                 680                 685             


Phe Ala His Arg Ser Gly Cys His Ser Gly Gln Gln Thr Asp Leu Arg 
    690                 695                 700                 


Arg Lys Ser Ala Leu Gly Lys Ala Thr Thr Leu Val Ser Thr Ala Ser 
705                 710                 715                 720 


Gly Thr Gln Thr Val Phe Pro Ser Lys 
                725                 


<210>  437
<211>  398
<212>  PRT
<213>  Homo sapiens

<400>  437

Met Ser Gly Ser Ser Leu Pro Ser Ala Leu Ala Leu Ser Leu Leu Leu 
1               5                   10                  15      


Val Ser Gly Ser Leu Leu Pro Gly Pro Gly Ala Ala Gln Asn Ala Gly 
            20                  25                  30          


Phe Val Lys Ser Pro Met Ser Glu Thr Lys Leu Thr Gly Asp Ala Phe 
        35                  40                  45              


Glu Leu Tyr Cys Asp Val Val Gly Ser Pro Thr Pro Glu Ile Gln Trp 
    50                  55                  60                  


Trp Tyr Ala Glu Val Asn Arg Ala Glu Ser Phe Arg Gln Leu Trp Asp 
65                  70                  75                  80  


Gly Ala Arg Lys Arg Arg Val Thr Val Asn Thr Ala Tyr Gly Ser Asn 
                85                  90                  95      


Gly Val Ser Val Leu Arg Ile Thr Arg Leu Thr Leu Glu Asp Ser Gly 
            100                 105                 110         


Thr Tyr Glu Cys Arg Ala Ser Asn Asp Pro Lys Arg Asn Asp Leu Arg 
        115                 120                 125             


Gln Asn Pro Ser Ile Thr Trp Ile Arg Ala Gln Ala Thr Ile Ser Val 
    130                 135                 140                 


Leu Gln Lys Pro Arg Ile Val Thr Ser Glu Glu Val Ile Ile Arg Asp 
145                 150                 155                 160 


Ser Pro Val Leu Pro Val Thr Leu Gln Cys Asn Leu Thr Ser Ser Ser 
                165                 170                 175     


His Thr Leu Thr Tyr Ser Tyr Trp Thr Lys Asn Gly Val Glu Leu Ser 
            180                 185                 190         


Ala Thr Arg Lys Asn Ala Ser Asn Met Glu Tyr Arg Ile Asn Lys Pro 
        195                 200                 205             


Arg Ala Glu Asp Ser Gly Glu Tyr His Cys Val Tyr His Phe Val Ser 
    210                 215                 220                 


Ala Pro Lys Ala Asn Ala Thr Ile Glu Val Lys Ala Ala Pro Asp Ile 
225                 230                 235                 240 


Thr Gly His Lys Arg Ser Glu Asn Lys Asn Glu Gly Gln Asp Ala Thr 
                245                 250                 255     


Met Tyr Cys Lys Ser Val Gly Tyr Pro His Pro Asp Trp Ile Trp Arg 
            260                 265                 270         


Lys Lys Glu Asn Gly Met Pro Met Asp Ile Val Asn Thr Ser Gly Arg 
        275                 280                 285             


Phe Phe Ile Ile Asn Lys Glu Asn Tyr Thr Glu Leu Asn Ile Val Asn 
    290                 295                 300                 


Leu Gln Ile Thr Glu Asp Pro Gly Glu Tyr Glu Cys Asn Ala Thr Asn 
305                 310                 315                 320 


Ala Ile Gly Ser Ala Ser Val Val Thr Val Leu Arg Val Arg Ser His 
                325                 330                 335     


Leu Ala Pro Leu Trp Pro Phe Leu Gly Ile Leu Ala Glu Ile Ile Ile 
            340                 345                 350         


Leu Val Val Ile Ile Val Val Tyr Glu Lys Arg Lys Arg Pro Asp Glu 
        355                 360                 365             


Val Pro Asp Asp Asp Glu Pro Ala Gly Pro Met Lys Thr Asn Ser Thr 
    370                 375                 380                 


Asn Asn His Lys Asp Lys Asn Leu Arg Gln Arg Asn Thr Asn 
385                 390                 395             


<210>  438
<211>  282
<212>  PRT
<213>  Homo sapiens

<400>  438

Met Ser Gly Ser Ser Leu Pro Ser Ala Leu Ala Leu Ser Leu Leu Leu 
1               5                   10                  15      


Val Ser Gly Ser Leu Leu Pro Gly Pro Gly Ala Ala Gln Asn Glu Pro 
            20                  25                  30          


Arg Ile Val Thr Ser Glu Glu Val Ile Ile Arg Asp Ser Pro Val Leu 
        35                  40                  45              


Pro Val Thr Leu Gln Cys Asn Leu Thr Ser Ser Ser His Thr Leu Thr 
    50                  55                  60                  


Tyr Ser Tyr Trp Thr Lys Asn Gly Val Glu Leu Ser Ala Thr Arg Lys 
65                  70                  75                  80  


Asn Ala Ser Asn Met Glu Tyr Arg Ile Asn Lys Pro Arg Ala Glu Asp 
                85                  90                  95      


Ser Gly Glu Tyr His Cys Val Tyr His Phe Val Ser Ala Pro Lys Ala 
            100                 105                 110         


Asn Ala Thr Ile Glu Val Lys Ala Ala Pro Asp Ile Thr Gly His Lys 
        115                 120                 125             


Arg Ser Glu Asn Lys Asn Glu Gly Gln Asp Ala Thr Met Tyr Cys Lys 
    130                 135                 140                 


Ser Val Gly Tyr Pro His Pro Asp Trp Ile Trp Arg Lys Lys Glu Asn 
145                 150                 155                 160 


Gly Met Pro Met Asp Ile Val Asn Thr Ser Gly Arg Phe Phe Ile Ile 
                165                 170                 175     


Asn Lys Glu Asn Tyr Thr Glu Leu Asn Ile Val Asn Leu Gln Ile Thr 
            180                 185                 190         


Glu Asp Pro Gly Glu Tyr Glu Cys Asn Ala Thr Asn Ala Ile Gly Ser 
        195                 200                 205             


Ala Ser Val Val Thr Val Leu Arg Val Arg Ser His Leu Ala Pro Leu 
    210                 215                 220                 


Trp Pro Phe Leu Gly Ile Leu Ala Glu Ile Ile Ile Leu Val Val Ile 
225                 230                 235                 240 


Ile Val Val Tyr Glu Lys Arg Lys Arg Pro Asp Glu Val Pro Asp Asp 
                245                 250                 255     


Asp Glu Pro Ala Gly Pro Met Lys Thr Asn Ser Thr Asn Asn His Lys 
            260                 265                 270         


Asp Lys Asn Leu Arg Gln Arg Asn Thr Asn 
        275                 280         


<210>  439
<211>  278
<212>  PRT
<213>  Homo sapiens

<400>  439

Met Ser Gly Ser Ser Leu Pro Ser Ala Leu Ala Leu Ser Leu Leu Leu 
1               5                   10                  15      


Val Ser Gly Ser Leu Leu Pro Gly Pro Gly Ala Ala Gln Asn Glu Pro 
            20                  25                  30          


Arg Ile Val Thr Ser Glu Glu Val Ile Ile Arg Asp Ser Pro Val Leu 
        35                  40                  45              


Pro Val Thr Leu Gln Cys Asn Leu Thr Ser Ser Ser His Thr Leu Thr 
    50                  55                  60                  


Tyr Ser Tyr Trp Thr Lys Asn Gly Val Glu Leu Ser Ala Thr Arg Lys 
65                  70                  75                  80  


Asn Ala Ser Asn Met Glu Tyr Arg Ile Asn Lys Pro Arg Ala Glu Asp 
                85                  90                  95      


Ser Gly Glu Tyr His Cys Val Tyr His Phe Val Ser Ala Pro Lys Ala 
            100                 105                 110         


Asn Ala Thr Ile Glu Val Lys Ala Ala Pro Asp Ile Thr Gly His Lys 
        115                 120                 125             


Arg Ser Glu Asn Lys Asn Glu Gly Gln Asp Ala Thr Met Tyr Cys Lys 
    130                 135                 140                 


Ser Val Gly Tyr Pro His Pro Asp Trp Ile Trp Arg Lys Lys Glu Asn 
145                 150                 155                 160 


Gly Met Pro Met Asp Ile Val Asn Thr Ser Gly Arg Phe Phe Ile Ile 
                165                 170                 175     


Asn Lys Glu Asn Tyr Thr Glu Leu Asn Ile Val Asn Leu Gln Ile Thr 
            180                 185                 190         


Glu Asp Pro Gly Glu Tyr Glu Cys Asn Ala Thr Asn Ala Ile Gly Ser 
        195                 200                 205             


Ala Ser Val Val Thr Val Leu Arg Val Arg Ser His Leu Ala Pro Leu 
    210                 215                 220                 


Trp Pro Phe Leu Gly Ile Leu Ala Glu Ile Ile Ile Leu Val Val Ile 
225                 230                 235                 240 


Ile Val Val Tyr Glu Lys Arg Lys Arg Pro Asp Glu Val Pro Asp Ala 
                245                 250                 255     


Gly Pro Met Lys Thr Asn Ser Thr Asn Asn His Lys Asp Lys Asn Leu 
            260                 265                 270         


Arg Gln Arg Asn Thr Asn 
        275             


<210>  440
<211>  394
<212>  PRT
<213>  Homo sapiens

<400>  440

Met Ser Gly Ser Ser Leu Pro Ser Ala Leu Ala Leu Ser Leu Leu Leu 
1               5                   10                  15      


Val Ser Gly Ser Leu Leu Pro Gly Pro Gly Ala Ala Gln Asn Ala Gly 
            20                  25                  30          


Phe Val Lys Ser Pro Met Ser Glu Thr Lys Leu Thr Gly Asp Ala Phe 
        35                  40                  45              


Glu Leu Tyr Cys Asp Val Val Gly Ser Pro Thr Pro Glu Ile Gln Trp 
    50                  55                  60                  


Trp Tyr Ala Glu Val Asn Arg Ala Glu Ser Phe Arg Gln Leu Trp Asp 
65                  70                  75                  80  


Gly Ala Arg Lys Arg Arg Val Thr Val Asn Thr Ala Tyr Gly Ser Asn 
                85                  90                  95      


Gly Val Ser Val Leu Arg Ile Thr Arg Leu Thr Leu Glu Asp Ser Gly 
            100                 105                 110         


Thr Tyr Glu Cys Arg Ala Ser Asn Asp Pro Lys Arg Asn Asp Leu Arg 
        115                 120                 125             


Gln Asn Pro Ser Ile Thr Trp Ile Arg Ala Gln Ala Thr Ile Ser Val 
    130                 135                 140                 


Leu Gln Lys Pro Arg Ile Val Thr Ser Glu Glu Val Ile Ile Arg Asp 
145                 150                 155                 160 


Ser Pro Val Leu Pro Val Thr Leu Gln Cys Asn Leu Thr Ser Ser Ser 
                165                 170                 175     


His Thr Leu Thr Tyr Ser Tyr Trp Thr Lys Asn Gly Val Glu Leu Ser 
            180                 185                 190         


Ala Thr Arg Lys Asn Ala Ser Asn Met Glu Tyr Arg Ile Asn Lys Pro 
        195                 200                 205             


Arg Ala Glu Asp Ser Gly Glu Tyr His Cys Val Tyr His Phe Val Ser 
    210                 215                 220                 


Ala Pro Lys Ala Asn Ala Thr Ile Glu Val Lys Ala Ala Pro Asp Ile 
225                 230                 235                 240 


Thr Gly His Lys Arg Ser Glu Asn Lys Asn Glu Gly Gln Asp Ala Thr 
                245                 250                 255     


Met Tyr Cys Lys Ser Val Gly Tyr Pro His Pro Asp Trp Ile Trp Arg 
            260                 265                 270         


Lys Lys Glu Asn Gly Met Pro Met Asp Ile Val Asn Thr Ser Gly Arg 
        275                 280                 285             


Phe Phe Ile Ile Asn Lys Glu Asn Tyr Thr Glu Leu Asn Ile Val Asn 
    290                 295                 300                 


Leu Gln Ile Thr Glu Asp Pro Gly Glu Tyr Glu Cys Asn Ala Thr Asn 
305                 310                 315                 320 


Ala Ile Gly Ser Ala Ser Val Val Thr Val Leu Arg Val Arg Ser His 
                325                 330                 335     


Leu Ala Pro Leu Trp Pro Phe Leu Gly Ile Leu Ala Glu Ile Ile Ile 
            340                 345                 350         


Leu Val Val Ile Ile Val Val Tyr Glu Lys Arg Lys Arg Pro Asp Glu 
        355                 360                 365             


Val Pro Asp Ala Gly Pro Met Lys Thr Asn Ser Thr Asn Asn His Lys 
    370                 375                 380                 


Asp Lys Asn Leu Arg Gln Arg Asn Thr Asn 
385                 390                 


<210>  441
<211>  184
<212>  PRT
<213>  Homo sapiens

<400>  441

Met Ser Gly Ser Ser Leu Pro Ser Ala Leu Ala Leu Ser Leu Leu Leu 
1               5                   10                  15      


Val Ser Gly Ser Leu Leu Pro Gly Pro Gly Ala Ala Gln Asn Ala Ala 
            20                  25                  30          


Pro Asp Ile Thr Gly His Lys Arg Ser Glu Asn Lys Asn Glu Gly Gln 
        35                  40                  45              


Asp Ala Thr Met Tyr Cys Lys Ser Val Gly Tyr Pro His Pro Asp Trp 
    50                  55                  60                  


Ile Trp Arg Lys Lys Glu Asn Gly Met Pro Met Asp Ile Val Asn Thr 
65                  70                  75                  80  


Ser Gly Arg Phe Phe Ile Ile Asn Lys Glu Asn Tyr Thr Glu Leu Asn 
                85                  90                  95      


Ile Val Asn Leu Gln Ile Thr Glu Asp Pro Gly Glu Tyr Glu Cys Asn 
            100                 105                 110         


Ala Thr Asn Ala Ile Gly Ser Ala Ser Val Val Thr Val Leu Arg Val 
        115                 120                 125             


Arg Ser His Leu Ala Pro Leu Trp Pro Phe Leu Gly Ile Leu Ala Glu 
    130                 135                 140                 


Ile Ile Ile Leu Val Val Ile Ile Val Val Tyr Glu Lys Arg Lys Arg 
145                 150                 155                 160 


Pro Asp Glu Val Pro Asp Asp Asp Glu Pro Ala Gly Pro Met Lys Thr 
                165                 170                 175     


Asn Ser Thr Asn Asn His Lys Asp 
            180                 


<210>  442
<211>  518
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  442

Xaa Arg Lys Trp Ser Arg Gln Phe Leu Leu Ser Phe Trp Cys Thr Val 
1               5                   10                  15      


Cys Ser Ala His Gln Gly Thr Ile Phe Leu Ser Leu Lys Ile Gln Phe 
            20                  25                  30          


Ala Asp Gln Lys Gln Glu Phe Asn Lys Arg Pro Thr Lys Ile Gly Arg 
        35                  40                  45              


Arg Ser Leu Ser Arg Ser Ile Ser Gln Ser Ser Thr Asp Ser Tyr Ser 
    50                  55                  60                  


Ser Ala Ala Ser Tyr Thr Asp Ser Ser Asp Asp Glu Thr Ser Pro Arg 
65                  70                  75                  80  


Asp Lys Gln Gln Lys Asn Ser Lys Gly Ser Ser Asp Phe Cys Val Lys 
                85                  90                  95      


Asn Ile Lys Gln Ala Glu Phe Gly Arg Arg Glu Ile Glu Ile Ala Glu 
            100                 105                 110         


Gln Glu Met Pro Ala Leu Met Ala Leu Arg Lys Arg Ala Gln Gly Glu 
        115                 120                 125             


Lys Pro Leu Ala Gly Ala Lys Ile Val Gly Cys Thr His Ile Thr Ala 
    130                 135                 140                 


Gln Thr Ala Val Leu Met Glu Thr Leu Gly Ala Leu Gly Ala Gln Cys 
145                 150                 155                 160 


Arg Trp Ala Ala Cys Asn Ile Tyr Ser Thr Leu Asn Glu Val Ala Ala 
                165                 170                 175     


Ala Leu Ala Glu Ser Gly Phe Pro Val Phe Ala Trp Lys Gly Glu Ser 
            180                 185                 190         


Glu Asp Asp Phe Trp Trp Cys Ile Asp Arg Cys Val Asn Val Glu Gly 
        195                 200                 205             


Trp Gln Pro Asn Met Ile Leu Asp Asp Gly Gly Asp Leu Thr His Trp 
    210                 215                 220                 


Ile Tyr Lys Lys Tyr Pro Asn Met Phe Lys Lys Ile Lys Gly Ile Val 
225                 230                 235                 240 


Glu Glu Ser Val Thr Gly Val His Arg Leu Tyr Gln Leu Ser Lys Ala 
                245                 250                 255     


Gly Lys Leu Cys Val Pro Ala Met Asn Val Asn Asp Ser Val Thr Lys 
            260                 265                 270         


Gln Lys Phe Asp Asn Leu Tyr Cys Cys Arg Glu Ser Ile Leu Asp Gly 
        275                 280                 285             


Leu Lys Arg Thr Thr Asp Met Met Phe Gly Gly Lys Gln Val Val Val 
    290                 295                 300                 


Cys Gly Tyr Gly Glu Val Gly Lys Gly Cys Cys Ala Ala Leu Lys Ala 
305                 310                 315                 320 


Met Gly Ser Ile Val Tyr Val Thr Glu Ile Asp Pro Ile Cys Ala Leu 
                325                 330                 335     


Gln Ala Cys Met Asp Gly Phe Arg Leu Val Lys Leu Asn Glu Val Ile 
            340                 345                 350         


Arg Gln Val Asp Ile Val Ile Thr Cys Thr Gly Asn Lys Asn Val Val 
        355                 360                 365             


Thr Arg Glu His Leu Asp Arg Met Lys Asn Ser Cys Ile Val Cys Asn 
    370                 375                 380                 


Met Gly His Ser Asn Thr Glu Ile Asp Val Ala Ser Leu Arg Thr Pro 
385                 390                 395                 400 


Glu Leu Thr Trp Glu Arg Val Arg Ser Gln Val Asp His Val Ile Trp 
                405                 410                 415     


Pro Asp Gly Lys Arg Ile Val Leu Leu Ala Glu Gly Arg Leu Leu Asn 
            420                 425                 430         


Leu Ser Cys Ser Thr Val Pro Thr Phe Val Leu Ser Ile Thr Ala Thr 
        435                 440                 445             


Thr Gln Ala Leu Ala Leu Ile Glu Leu Tyr Asn Ala Pro Glu Gly Arg 
    450                 455                 460                 


Tyr Lys Gln Asp Val Tyr Leu Leu Pro Lys Lys Met Asp Glu Tyr Val 
465                 470                 475                 480 


Ala Ser Leu His Leu Pro Thr Phe Asp Ala His Leu Thr Glu Leu Thr 
                485                 490                 495     


Asp Glu Gln Ala Lys Tyr Leu Gly Leu Asn Lys Asn Gly Pro Phe Lys 
            500                 505                 510         


Pro Asn Tyr Tyr Arg Tyr 
        515             


<210>  443
<211>  386
<212>  PRT
<213>  Homo sapiens

<400>  443

Met Ala Asp Ser Cys Arg Asn Leu Thr Tyr Val Arg Gly Ser Val Gly 
1               5                   10                  15      


Pro Ala Thr Ser Thr Leu Met Phe Val Ala Gly Val Val Gly Asn Gly 
            20                  25                  30          


Leu Ala Leu Gly Ile Leu Ser Ala Arg Arg Pro Ala Arg Pro Ser Ala 
        35                  40                  45              


Phe Ala Val Leu Val Thr Gly Leu Ala Ala Thr Asp Leu Leu Gly Thr 
    50                  55                  60                  


Ser Phe Leu Ser Pro Ala Val Phe Val Ala Tyr Ala Arg Asn Ser Ser 
65                  70                  75                  80  


Leu Leu Gly Leu Ala Arg Gly Gly Pro Ala Leu Cys Asp Ala Phe Ala 
                85                  90                  95      


Phe Ala Met Thr Phe Phe Gly Leu Ala Ser Met Leu Ile Leu Phe Ala 
            100                 105                 110         


Met Ala Val Glu Arg Cys Leu Ala Leu Ser His Pro Tyr Leu Tyr Ala 
        115                 120                 125             


Gln Leu Asp Gly Pro Arg Cys Ala Arg Leu Ala Leu Pro Ala Ile Tyr 
    130                 135                 140                 


Ala Phe Cys Val Leu Phe Cys Ala Leu Pro Leu Leu Gly Leu Gly Gln 
145                 150                 155                 160 


His Gln Gln Tyr Cys Pro Gly Ser Trp Cys Phe Leu Arg Met Arg Trp 
                165                 170                 175     


Ala Gln Pro Gly Gly Ala Ala Phe Ser Leu Ala Tyr Ala Gly Leu Val 
            180                 185                 190         


Ala Leu Leu Val Ala Ala Ile Phe Leu Cys Asn Gly Ser Val Thr Leu 
        195                 200                 205             


Ser Leu Cys Arg Met Tyr Arg Gln Gln Lys Arg His Gln Gly Ser Leu 
    210                 215                 220                 


Gly Pro Arg Pro Arg Thr Gly Glu Asp Glu Val Asp His Leu Ile Leu 
225                 230                 235                 240 


Leu Ala Leu Met Thr Val Val Met Ala Val Cys Ser Leu Pro Leu Thr 
                245                 250                 255     


Ile Arg Cys Phe Thr Gln Ala Val Ala Pro Asp Ser Ser Ser Glu Met 
            260                 265                 270         


Gly Asp Leu Leu Ala Phe Arg Phe Tyr Ala Phe Asn Pro Ile Leu Asp 
        275                 280                 285             


Pro Trp Val Phe Ile Leu Phe Arg Lys Ala Val Phe Gln Arg Leu Lys 
    290                 295                 300                 


Leu Trp Val Cys Cys Leu Cys Leu Gly Pro Ala His Gly Asp Ser Gln 
305                 310                 315                 320 


Thr Pro Leu Ser Gln Leu Ala Ser Gly Arg Arg Asp Pro Arg Ala Pro 
                325                 330                 335     


Ser Ala Pro Val Gly Lys Glu Gly Ser Cys Val Pro Leu Ser Ala Trp 
            340                 345                 350         


Gly Glu Gly Gln Val Glu Pro Leu Pro Pro Thr Gln Gln Ser Ser Gly 
        355                 360                 365             


Ser Ala Val Gly Thr Ser Ser Lys Ala Glu Ala Ser Val Ala Cys Ser 
    370                 375                 380                 


Leu Cys 
385     


<210>  444
<211>  143
<212>  PRT
<213>  Homo sapiens

<400>  444

Met Thr Val Val Met Ala Val Cys Ser Leu Pro Leu Thr Ile Arg Cys 
1               5                   10                  15      


Phe Thr Gln Ala Val Ala Pro Asp Ser Ser Ser Glu Met Gly Asp Leu 
            20                  25                  30          


Leu Ala Phe Arg Phe Tyr Ala Phe Asn Pro Ile Leu Asp Pro Trp Val 
        35                  40                  45              


Phe Ile Leu Phe Arg Lys Ala Val Phe Gln Arg Leu Lys Leu Trp Val 
    50                  55                  60                  


Cys Cys Leu Cys Leu Gly Pro Ala His Gly Asp Ser Gln Thr Pro Leu 
65                  70                  75                  80  


Ser Gln Leu Ala Ser Gly Arg Arg Asp Pro Arg Ala Pro Ser Ala Pro 
                85                  90                  95      


Val Gly Lys Glu Gly Ser Cys Val Pro Leu Ser Ala Trp Gly Glu Gly 
            100                 105                 110         


Gln Val Glu Pro Leu Pro Pro Thr Gln Gln Ser Ser Gly Ser Ala Val 
        115                 120                 125             


Gly Thr Ser Ser Lys Ala Glu Ala Ser Val Ala Cys Ser Leu Cys 
    130                 135                 140             


<210>  445
<211>  296
<212>  PRT
<213>  Homo sapiens

<400>  445

Met Ala Asp Ser Cys Arg Asn Leu Thr Tyr Val Arg Gly Ser Val Gly 
1               5                   10                  15      


Pro Ala Thr Ser Thr Leu Met Phe Val Ala Gly Val Val Gly Asn Gly 
            20                  25                  30          


Leu Ala Leu Gly Ile Leu Ser Ala Arg Arg Pro Ala Arg Pro Ser Ala 
        35                  40                  45              


Phe Ala Val Leu Val Thr Gly Leu Ala Ala Thr Asp Leu Leu Gly Thr 
    50                  55                  60                  


Ser Phe Leu Ser Pro Ala Val Phe Val Ala Tyr Ala Arg Asn Ser Ser 
65                  70                  75                  80  


Leu Leu Gly Leu Ala Arg Gly Gly Pro Ala Leu Cys Asp Ala Phe Ala 
                85                  90                  95      


Phe Ala Met Thr Phe Phe Gly Leu Ala Ser Met Leu Ile Leu Phe Ala 
            100                 105                 110         


Met Ala Val Glu Arg Cys Leu Ala Leu Ser His Pro Tyr Leu Tyr Ala 
        115                 120                 125             


Gln Leu Asp Gly Pro Arg Cys Ala Arg Leu Ala Leu Pro Ala Ile Tyr 
    130                 135                 140                 


Ala Phe Cys Val Leu Phe Cys Ala Leu Pro Leu Leu Gly Leu Gly Gln 
145                 150                 155                 160 


His Gln Gln Tyr Cys Pro Gly Ser Trp Cys Phe Leu Arg Met Arg Trp 
                165                 170                 175     


Ala Gln Pro Gly Gly Ala Ala Phe Ser Leu Ala Tyr Ala Gly Leu Val 
            180                 185                 190         


Ala Leu Leu Val Ala Ala Ile Phe Leu Cys Asn Gly Ser Val Thr Leu 
        195                 200                 205             


Ser Leu Cys Arg Met Tyr Arg Gln Gln Lys Arg His Gln Gly Ser Leu 
    210                 215                 220                 


Gly Pro Arg Pro Arg Thr Gly Glu Asp Glu Val Asp His Leu Ile Leu 
225                 230                 235                 240 


Leu Ala Leu Met Thr Val Val Met Ala Val Cys Ser Leu Pro Leu Thr 
                245                 250                 255     


His Val Glu Arg Pro Arg Gln Asp Arg Met Arg Trp Leu Thr Pro Val 
            260                 265                 270         


Ile Pro Ala Leu Trp Glu Ala Glu Ala Gly Gly Ser Phe Glu Val Arg 
        275                 280                 285             


Ser Ser Arg Pro Val Trp Pro Thr 
    290                 295     


<210>  446
<211>  115
<212>  PRT
<213>  Homo sapiens

<400>  446

Met Gly Asp Leu Leu Ala Phe Arg Phe Tyr Ala Phe Asn Pro Ile Leu 
1               5                   10                  15      


Asp Pro Trp Val Phe Ile Leu Phe Arg Lys Ala Val Phe Gln Arg Leu 
            20                  25                  30          


Lys Leu Trp Val Cys Cys Leu Cys Leu Gly Pro Ala His Gly Asp Ser 
        35                  40                  45              


Gln Thr Pro Leu Ser Gln Leu Ala Ser Gly Arg Arg Asp Pro Arg Ala 
    50                  55                  60                  


Pro Ser Ala Pro Val Gly Lys Glu Gly Ser Cys Val Pro Leu Ser Ala 
65                  70                  75                  80  


Trp Gly Glu Gly Gln Val Glu Pro Leu Pro Pro Thr Gln Gln Ser Ser 
                85                  90                  95      


Gly Ser Ala Val Gly Thr Ser Ser Lys Ala Glu Ala Ser Val Ala Cys 
            100                 105                 110         


Ser Leu Cys 
        115 


<210>  447
<211>  174
<212>  PRT
<213>  Homo sapiens

<400>  447

Met Tyr Arg Gln Gln Lys Arg His Gln Gly Ser Leu Gly Pro Arg Pro 
1               5                   10                  15      


Arg Thr Gly Glu Asp Glu Val Asp His Leu Ile Leu Leu Ala Leu Met 
            20                  25                  30          


Thr Val Val Met Ala Val Cys Ser Leu Pro Leu Thr Ile Arg Cys Phe 
        35                  40                  45              


Thr Gln Ala Val Ala Pro Asp Ser Ser Ser Glu Met Gly Asp Leu Leu 
    50                  55                  60                  


Ala Phe Arg Phe Tyr Ala Phe Asn Pro Ile Leu Asp Pro Trp Val Phe 
65                  70                  75                  80  


Ile Leu Phe Arg Lys Ala Val Phe Gln Arg Leu Lys Leu Trp Val Cys 
                85                  90                  95      


Cys Leu Cys Leu Gly Pro Ala His Gly Asp Ser Gln Thr Pro Leu Ser 
            100                 105                 110         


Gln Leu Ala Ser Gly Arg Arg Asp Pro Arg Ala Pro Ser Ala Pro Val 
        115                 120                 125             


Gly Lys Glu Gly Ser Cys Val Pro Leu Ser Ala Trp Gly Glu Gly Gln 
    130                 135                 140                 


Val Glu Pro Leu Pro Pro Thr Gln Gln Ser Ser Gly Ser Ala Val Gly 
145                 150                 155                 160 


Thr Ser Ser Lys Ala Glu Ala Ser Val Ala Cys Ser Leu Cys 
                165                 170                 


<210>  448
<211>  454
<212>  PRT
<213>  Homo sapiens

<400>  448

Met Gly Glu Asn Asp Pro Pro Ala Val Glu Ala Pro Phe Ser Phe Arg 
1               5                   10                  15      


Ser Leu Phe Gly Leu Asp Asp Leu Lys Ile Ser Pro Val Ala Pro Asp 
            20                  25                  30          


Ala Asp Ala Val Ala Ala Gln Ile Leu Ser Leu Leu Pro Leu Lys Phe 
        35                  40                  45              


Phe Pro Ile Ile Val Ile Gly Ile Ile Ala Leu Ile Leu Ala Leu Ala 
    50                  55                  60                  


Ile Gly Leu Gly Ile His Phe Asp Cys Ser Gly Lys Tyr Arg Cys Arg 
65                  70                  75                  80  


Ser Ser Phe Lys Cys Ile Glu Leu Ile Ala Arg Cys Asp Gly Val Ser 
                85                  90                  95      


Asp Cys Lys Asp Gly Glu Asp Glu Tyr Arg Cys Val Arg Val Gly Gly 
            100                 105                 110         


Gln Asn Ala Val Leu Gln Val Phe Thr Ala Ala Ser Trp Lys Thr Met 
        115                 120                 125             


Cys Ser Asp Asp Trp Lys Gly His Tyr Ala Asn Val Ala Cys Ala Gln 
    130                 135                 140                 


Leu Gly Phe Pro Ser Tyr Val Ser Ser Asp Asn Leu Arg Val Ser Ser 
145                 150                 155                 160 


Leu Glu Gly Gln Phe Arg Glu Glu Phe Val Ser Ile Asp His Leu Leu 
                165                 170                 175     


Pro Asp Asp Lys Val Thr Ala Leu His His Ser Val Tyr Val Arg Glu 
            180                 185                 190         


Gly Cys Ala Ser Gly His Val Val Thr Leu Gln Cys Thr Ala Cys Gly 
        195                 200                 205             


His Arg Arg Gly Tyr Ser Ser Arg Ile Val Gly Gly Asn Met Ser Leu 
    210                 215                 220                 


Leu Ser Gln Trp Pro Trp Gln Ala Ser Leu Gln Phe Gln Gly Tyr His 
225                 230                 235                 240 


Leu Cys Gly Gly Ser Val Ile Thr Pro Leu Trp Ile Ile Thr Ala Ala 
                245                 250                 255     


His Cys Val Tyr Asp Leu Tyr Leu Pro Lys Ser Trp Thr Ile Gln Val 
            260                 265                 270         


Gly Leu Val Ser Leu Leu Asp Asn Pro Ala Pro Ser His Leu Val Glu 
        275                 280                 285             


Lys Ile Val Tyr His Ser Lys Tyr Lys Pro Lys Arg Leu Gly Asn Asp 
    290                 295                 300                 


Ile Ala Leu Met Lys Leu Ala Gly Pro Leu Thr Phe Asn Glu Met Ile 
305                 310                 315                 320 


Gln Pro Val Cys Leu Pro Asn Ser Glu Glu Asn Phe Pro Asp Gly Lys 
                325                 330                 335     


Val Cys Trp Thr Ser Gly Trp Gly Ala Thr Glu Asp Gly Ala Gly Asp 
            340                 345                 350         


Ala Ser Pro Val Leu Asn His Ala Ala Val Pro Leu Ile Ser Asn Lys 
        355                 360                 365             


Ile Cys Asn His Arg Asp Val Tyr Gly Gly Ile Ile Ser Pro Ser Met 
    370                 375                 380                 


Leu Cys Ala Gly Tyr Leu Thr Gly Gly Val Asp Ser Cys Gln Gly Asp 
385                 390                 395                 400 


Ser Gly Gly Pro Leu Val Cys Gln Glu Arg Arg Leu Trp Lys Leu Val 
                405                 410                 415     


Gly Ala Thr Ser Phe Gly Ile Gly Cys Ala Glu Val Asn Lys Pro Gly 
            420                 425                 430         


Val Tyr Thr Arg Val Thr Ser Phe Leu Asp Trp Ile His Glu Gln Met 
        435                 440                 445             


Glu Arg Asp Leu Lys Thr 
    450                 


<210>  449
<211>  344
<212>  PRT
<213>  Homo sapiens

<400>  449

Met Gly Glu Asn Asp Pro Pro Ala Val Glu Ala Pro Phe Ser Phe Arg 
1               5                   10                  15      


Ser Leu Phe Gly Leu Asp Asp Leu Lys Ile Ser Pro Val Ala Pro Asp 
            20                  25                  30          


Ala Asp Ala Val Ala Ala Gln Ile Leu Ser Leu Leu Pro Leu Lys Phe 
        35                  40                  45              


Phe Pro Ile Ile Val Ile Gly Ile Ile Ala Leu Ile Leu Ala Leu Ala 
    50                  55                  60                  


Ile Gly Leu Gly Ile His Phe Asp Cys Ser Gly Lys Tyr Arg Cys Arg 
65                  70                  75                  80  


Ser Ser Phe Lys Cys Ile Glu Leu Ile Ala Arg Cys Asp Gly Val Ser 
                85                  90                  95      


Asp Cys Lys Asp Gly Glu Asp Glu Tyr Arg Cys Val Arg Val Gly Gly 
            100                 105                 110         


Gln Asn Ala Val Leu Gln Val Phe Thr Ala Ala Ser Trp Lys Thr Met 
        115                 120                 125             


Cys Ser Asp Asp Trp Lys Gly His Tyr Ala Asn Val Ala Cys Ala Gln 
    130                 135                 140                 


Leu Gly Phe Pro Ser Tyr Val Ser Ser Asp Asn Leu Arg Val Ser Ser 
145                 150                 155                 160 


Leu Glu Gly Gln Phe Arg Glu Glu Phe Val Ser Ile Asp His Leu Leu 
                165                 170                 175     


Pro Asp Asp Lys Val Thr Ala Leu His His Ser Val Tyr Val Arg Glu 
            180                 185                 190         


Gly Cys Ala Ser Gly His Val Val Thr Leu Gln Cys Thr Ala Cys Gly 
        195                 200                 205             


His Arg Arg Gly Tyr Ser Ser Arg Ile Val Gly Gly Asn Met Ser Leu 
    210                 215                 220                 


Leu Ser Gln Trp Pro Trp Gln Ala Ser Leu Gln Phe Gln Gly Tyr His 
225                 230                 235                 240 


Leu Cys Gly Gly Ser Val Ile Thr Pro Leu Trp Ile Ile Thr Ala Ala 
                245                 250                 255     


His Cys Val Tyr Asp Leu Tyr Leu Pro Lys Ser Trp Thr Ile Gln Val 
            260                 265                 270         


Gly Leu Val Ser Leu Leu Asp Asn Pro Ala Pro Ser His Leu Val Glu 
        275                 280                 285             


Lys Ile Val Tyr His Ser Lys Tyr Lys Pro Lys Arg Leu Gly Asn Asp 
    290                 295                 300                 


Ile Ala Leu Met Lys Leu Ala Gly Pro Leu Thr Phe Asn Gly Thr Ser 
305                 310                 315                 320 


Gly Ser Leu Cys Gly Ser Ala Ala Leu Pro Leu Phe Gln Glu Asp Leu 
                325                 330                 335     


Gln Leu Leu Ile Glu Ala Phe Leu 
            340                 


<210>  450
<211>  451
<212>  PRT
<213>  Homo sapiens

<400>  450

Met Gly Glu Asn Asp Pro Pro Ala Val Glu Ala Pro Phe Ser Phe Arg 
1               5                   10                  15      


Ser Leu Phe Gly Leu Asp Asp Leu Lys Ile Ser Pro Val Ala Pro Asp 
            20                  25                  30          


Ala Val Ala Ala Gln Ile Leu Ser Leu Leu Pro Leu Lys Phe Phe Pro 
        35                  40                  45              


Ile Ile Val Ile Gly Ile Ile Ala Leu Ile Leu Ala Leu Ala Ile Gly 
    50                  55                  60                  


Leu Gly Ile His Phe Asp Cys Ser Gly Lys Tyr Arg Cys Arg Ser Ser 
65                  70                  75                  80  


Phe Lys Cys Ile Glu Leu Ile Ala Arg Cys Asp Gly Val Ser Asp Cys 
                85                  90                  95      


Lys Asp Gly Glu Asp Glu Tyr Arg Cys Val Arg Val Gly Gly Gln Asn 
            100                 105                 110         


Ala Val Leu Gln Val Phe Thr Ala Ala Ser Trp Lys Thr Met Cys Ser 
        115                 120                 125             


Asp Asp Trp Lys Gly His Tyr Ala Asn Val Ala Cys Ala Gln Leu Gly 
    130                 135                 140                 


Phe Pro Ser Tyr Val Ser Ser Asp Asn Leu Arg Val Ser Ser Leu Glu 
145                 150                 155                 160 


Gly Gln Phe Arg Glu Glu Phe Val Ser Ile Asp His Leu Leu Pro Asp 
                165                 170                 175     


Asp Lys Val Thr Ala Leu His His Ser Val Tyr Val Arg Glu Gly Cys 
            180                 185                 190         


Ala Ser Gly His Val Val Thr Leu Gln Cys Thr Ala Cys Gly His Arg 
        195                 200                 205             


Arg Gly Tyr Ser Ser Arg Ile Val Gly Gly Asn Met Ser Leu Leu Ser 
    210                 215                 220                 


Gln Trp Pro Trp Gln Ala Ser Leu Gln Phe Gln Gly Tyr His Leu Cys 
225                 230                 235                 240 


Gly Gly Ser Val Ile Thr Pro Leu Trp Ile Ile Thr Ala Ala His Cys 
                245                 250                 255     


Val Tyr Asp Leu Tyr Leu Pro Lys Ser Trp Thr Ile Gln Val Gly Leu 
            260                 265                 270         


Val Ser Leu Leu Asp Asn Pro Ala Pro Ser His Leu Val Glu Lys Ile 
        275                 280                 285             


Val Tyr His Ser Lys Tyr Lys Pro Lys Arg Leu Gly Asn Asp Ile Ala 
    290                 295                 300                 


Leu Met Lys Leu Ala Gly Pro Leu Thr Phe Asn Glu Met Ile Gln Pro 
305                 310                 315                 320 


Val Cys Leu Pro Asn Ser Glu Glu Asn Phe Pro Asp Gly Lys Val Cys 
                325                 330                 335     


Trp Thr Ser Gly Trp Gly Ala Thr Glu Asp Gly Gly Asp Ala Ser Pro 
            340                 345                 350         


Val Leu Asn His Ala Ala Val Pro Leu Ile Ser Asn Lys Ile Cys Asn 
        355                 360                 365             


His Arg Asp Val Tyr Gly Gly Ile Ile Ser Pro Ser Met Leu Cys Ala 
    370                 375                 380                 


Gly Tyr Leu Thr Gly Gly Val Asp Ser Cys Gln Gly Asp Ser Gly Gly 
385                 390                 395                 400 


Pro Leu Val Cys Gln Glu Arg Arg Leu Trp Lys Leu Val Gly Ala Thr 
                405                 410                 415     


Ser Phe Gly Ile Gly Cys Ala Glu Val Asn Lys Pro Gly Val Tyr Thr 
            420                 425                 430         


Arg Val Thr Ser Phe Leu Asp Trp Ile His Glu Gln Met Glu Arg Asp 
        435                 440                 445             


Leu Lys Thr 
    450     


<210>  451
<211>  453
<212>  PRT
<213>  Homo sapiens

<400>  451

Met Gly Glu Asn Asp Pro Pro Ala Val Glu Ala Pro Phe Ser Phe Arg 
1               5                   10                  15      


Ser Leu Phe Gly Leu Asp Asp Leu Lys Ile Ser Pro Val Ala Pro Asp 
            20                  25                  30          


Ala Asp Ala Val Ala Ala Gln Ile Leu Ser Leu Leu Pro Leu Lys Phe 
        35                  40                  45              


Phe Pro Ile Ile Val Ile Gly Ile Ile Ala Leu Ile Leu Ala Leu Ala 
    50                  55                  60                  


Ile Gly Leu Gly Ile His Phe Asp Cys Ser Gly Lys Tyr Arg Cys Arg 
65                  70                  75                  80  


Ser Ser Phe Lys Cys Ile Glu Leu Ile Ala Arg Cys Asp Gly Val Ser 
                85                  90                  95      


Asp Cys Lys Asp Gly Glu Asp Glu Tyr Arg Cys Val Arg Val Gly Gly 
            100                 105                 110         


Gln Asn Ala Val Leu Gln Val Phe Thr Ala Ala Ser Trp Lys Thr Met 
        115                 120                 125             


Cys Ser Asp Asp Trp Lys Gly His Tyr Ala Asn Val Ala Cys Ala Gln 
    130                 135                 140                 


Leu Gly Phe Pro Ser Tyr Val Ser Ser Asp Asn Leu Arg Val Ser Ser 
145                 150                 155                 160 


Leu Glu Gly Gln Phe Arg Glu Glu Phe Val Ser Ile Asp His Leu Leu 
                165                 170                 175     


Pro Asp Asp Lys Val Thr Ala Leu His His Ser Val Tyr Val Arg Glu 
            180                 185                 190         


Gly Cys Ala Ser Gly His Val Val Thr Leu Gln Cys Thr Ala Cys Gly 
        195                 200                 205             


His Arg Arg Gly Tyr Ser Ser Arg Ile Val Gly Gly Asn Met Ser Leu 
    210                 215                 220                 


Leu Ser Gln Trp Pro Trp Gln Ala Ser Leu Gln Phe Gln Gly Tyr His 
225                 230                 235                 240 


Leu Cys Gly Gly Ser Val Ile Thr Pro Leu Trp Ile Ile Thr Ala Ala 
                245                 250                 255     


His Cys Val Tyr Asp Leu Tyr Leu Pro Lys Ser Trp Thr Ile Gln Val 
            260                 265                 270         


Gly Leu Val Ser Leu Leu Asp Asn Pro Ala Pro Ser His Leu Val Glu 
        275                 280                 285             


Lys Ile Val Tyr His Ser Lys Tyr Lys Pro Lys Arg Leu Gly Asn Asp 
    290                 295                 300                 


Ile Ala Leu Met Lys Leu Ala Gly Pro Leu Thr Phe Asn Glu Met Ile 
305                 310                 315                 320 


Gln Pro Val Cys Leu Pro Asn Ser Glu Glu Asn Phe Pro Asp Gly Lys 
                325                 330                 335     


Val Cys Trp Thr Ser Gly Trp Gly Ala Thr Glu Asp Gly Gly Asp Ala 
            340                 345                 350         


Ser Pro Val Leu Asn His Ala Ala Val Pro Leu Ile Ser Asn Lys Ile 
        355                 360                 365             


Cys Asn His Arg Asp Val Tyr Gly Gly Ile Ile Ser Pro Ser Met Leu 
    370                 375                 380                 


Cys Ala Gly Tyr Leu Thr Gly Gly Val Asp Ser Cys Gln Gly Asp Ser 
385                 390                 395                 400 


Gly Gly Pro Leu Val Cys Gln Glu Arg Arg Leu Trp Lys Leu Val Gly 
                405                 410                 415     


Ala Thr Ser Phe Gly Ile Gly Cys Ala Glu Val Asn Lys Pro Gly Val 
            420                 425                 430         


Tyr Thr Arg Val Thr Ser Phe Leu Asp Trp Ile His Glu Gln Met Glu 
        435                 440                 445             


Arg Asp Leu Lys Thr 
    450             


<210>  452
<211>  734
<212>  PRT
<213>  Homo sapiens

<400>  452

Met Leu Leu Trp Leu Leu Leu Leu Ile Leu Thr Pro Gly Arg Glu Gln 
1               5                   10                  15      


Ser Gly Val Ala Pro Lys Ala Val Leu Leu Leu Asn Pro Pro Trp Ser 
            20                  25                  30          


Thr Ala Phe Lys Gly Glu Lys Val Ala Leu Ile Cys Ser Ser Ile Ser 
        35                  40                  45              


His Ser Leu Ala Gln Gly Asp Thr Tyr Trp Tyr His Asp Glu Lys Leu 
    50                  55                  60                  


Leu Lys Ile Lys His Asp Lys Ile Gln Ile Thr Glu Pro Gly Asn Tyr 
65                  70                  75                  80  


Gln Cys Lys Thr Arg Gly Ser Ser Leu Ser Asp Ala Val His Val Glu 
                85                  90                  95      


Phe Ser Pro Asp Trp Leu Ile Leu Gln Ala Leu His Pro Val Phe Glu 
            100                 105                 110         


Gly Asp Asn Val Ile Leu Arg Cys Gln Gly Lys Asp Asn Lys Asn Thr 
        115                 120                 125             


His Gln Lys Val Tyr Tyr Lys Asp Gly Lys Gln Leu Pro Asn Ser Tyr 
    130                 135                 140                 


Asn Leu Glu Lys Ile Thr Val Asn Ser Val Ser Arg Asp Asn Ser Lys 
145                 150                 155                 160 


Tyr His Cys Thr Ala Tyr Arg Lys Phe Tyr Ile Leu Asp Ile Glu Val 
                165                 170                 175     


Thr Ser Lys Pro Leu Asn Ile Gln Val Gln Glu Leu Phe Leu His Pro 
            180                 185                 190         


Val Leu Arg Ala Ser Ser Ser Thr Pro Ile Glu Gly Ser Pro Met Thr 
        195                 200                 205             


Leu Thr Cys Glu Thr Gln Leu Ser Pro Gln Arg Pro Asp Val Gln Leu 
    210                 215                 220                 


Gln Phe Ser Leu Phe Arg Asp Ser Gln Thr Leu Gly Leu Gly Trp Ser 
225                 230                 235                 240 


Arg Ser Pro Arg Leu Gln Ile Pro Ala Met Trp Thr Glu Asp Ser Gly 
                245                 250                 255     


Ser Tyr Trp Cys Glu Val Glu Thr Val Thr His Ser Ile Lys Lys Arg 
            260                 265                 270         


Ser Leu Arg Ser Gln Ile Arg Val Gln Arg Val Pro Val Ser Asn Val 
        275                 280                 285             


Asn Leu Glu Ile Arg Pro Thr Gly Gly Gln Leu Ile Glu Gly Glu Asn 
    290                 295                 300                 


Met Val Leu Ile Cys Ser Val Ala Gln Gly Ser Gly Thr Val Thr Phe 
305                 310                 315                 320 


Ser Trp His Lys Glu Gly Arg Val Arg Ser Leu Gly Arg Lys Thr Gln 
                325                 330                 335     


Arg Ser Leu Leu Ala Glu Leu His Val Leu Thr Val Lys Glu Ser Asp 
            340                 345                 350         


Ala Gly Arg Tyr Tyr Cys Ala Ala Asp Asn Val His Ser Pro Ile Leu 
        355                 360                 365             


Ser Thr Trp Ile Arg Val Thr Val Arg Ile Pro Val Ser His Pro Val 
    370                 375                 380                 


Leu Thr Phe Arg Ala Pro Arg Ala His Thr Val Val Gly Asp Leu Leu 
385                 390                 395                 400 


Glu Leu His Cys Glu Ser Leu Arg Gly Ser Pro Pro Ile Leu Tyr Arg 
                405                 410                 415     


Phe Tyr His Glu Asp Val Thr Leu Gly Asn Ser Ser Ala Pro Ser Gly 
            420                 425                 430         


Gly Gly Ala Ser Phe Asn Leu Ser Leu Thr Ala Glu His Ser Gly Asn 
        435                 440                 445             


Tyr Ser Cys Asp Ala Asp Asn Gly Leu Gly Ala Gln His Ser His Gly 
    450                 455                 460                 


Val Ser Leu Arg Val Thr Val Pro Val Ser Arg Pro Val Leu Thr Leu 
465                 470                 475                 480 


Arg Ala Pro Gly Ala Gln Ala Val Val Gly Asp Leu Leu Glu Leu His 
                485                 490                 495     


Cys Glu Ser Leu Arg Gly Ser Phe Pro Ile Leu Tyr Trp Phe Tyr His 
            500                 505                 510         


Glu Asp Asp Thr Leu Gly Asn Ile Ser Ala His Ser Gly Gly Gly Ala 
        515                 520                 525             


Ser Phe Asn Leu Ser Leu Thr Thr Glu His Ser Gly Asn Tyr Ser Cys 
    530                 535                 540                 


Glu Ala Asp Asn Gly Leu Gly Ala Gln His Ser Lys Val Val Thr Leu 
545                 550                 555                 560 


Asn Val Thr Gly Thr Ser Arg Asn Arg Thr Gly Leu Thr Ala Ala Gly 
                565                 570                 575     


Ile Thr Gly Leu Val Leu Ser Ile Leu Val Leu Ala Ala Ala Ala Ala 
            580                 585                 590         


Leu Leu His Tyr Ala Arg Ala Arg Arg Lys Pro Gly Gly Leu Ser Ala 
        595                 600                 605             


Thr Gly Thr Ser Ser His Ser Pro Ser Glu Cys Gln Glu Pro Ser Ser 
    610                 615                 620                 


Ser Arg Pro Ser Arg Ile Asp Pro Gln Glu Pro Thr His Ser Lys Pro 
625                 630                 635                 640 


Leu Ala Pro Met Glu Leu Glu Pro Met Tyr Ser Asn Val Asn Pro Gly 
                645                 650                 655     


Asp Ser Asn Pro Ile Tyr Ser Gln Ile Trp Ser Ile Gln His Thr Lys 
            660                 665                 670         


Glu Asn Ser Ala Asn Cys Pro Met Met His Gln Glu His Glu Glu Leu 
        675                 680                 685             


Thr Val Leu Tyr Ser Glu Leu Lys Lys Thr His Pro Asp Asp Ser Ala 
    690                 695                 700                 


Gly Glu Ala Ser Ser Arg Gly Arg Ala His Glu Glu Asp Asp Glu Glu 
705                 710                 715                 720 


Asn Tyr Glu Asn Val Pro Arg Val Leu Leu Ala Ser Asp His 
                725                 730                 


<210>  453
<211>  742
<212>  PRT
<213>  Homo sapiens

<400>  453

Met Leu Leu Trp Leu Leu Leu Leu Ile Leu Thr Pro Gly Arg Glu Gln 
1               5                   10                  15      


Ser Gly Val Ala Pro Lys Ala Val Leu Leu Leu Asn Pro Pro Trp Ser 
            20                  25                  30          


Thr Ala Phe Lys Gly Glu Lys Val Ala Leu Ile Cys Ser Ser Ile Ser 
        35                  40                  45              


His Ser Leu Ala Gln Gly Asp Thr Tyr Trp Tyr His Asp Glu Lys Leu 
    50                  55                  60                  


Leu Lys Ile Lys His Asp Lys Ile Gln Ile Thr Glu Pro Gly Asn Tyr 
65                  70                  75                  80  


Gln Cys Lys Thr Arg Gly Ser Ser Leu Ser Asp Ala Val His Val Glu 
                85                  90                  95      


Phe Ser Pro Asp Trp Leu Ile Leu Gln Ala Leu His Pro Val Phe Glu 
            100                 105                 110         


Gly Asp Asn Val Ile Leu Arg Cys Gln Gly Lys Asp Asn Lys Asn Thr 
        115                 120                 125             


His Gln Lys Val Tyr Tyr Lys Asp Gly Lys Gln Leu Pro Asn Ser Tyr 
    130                 135                 140                 


Asn Leu Glu Lys Ile Thr Val Asn Ser Val Ser Arg Asp Asn Ser Lys 
145                 150                 155                 160 


Tyr His Cys Thr Ala Tyr Arg Lys Phe Tyr Ile Leu Asp Ile Glu Val 
                165                 170                 175     


Thr Ser Lys Pro Leu Asn Ile Gln Val Gln Glu Leu Phe Leu His Pro 
            180                 185                 190         


Val Leu Arg Ala Ser Ser Ser Thr Pro Ile Glu Gly Ser Pro Met Thr 
        195                 200                 205             


Leu Thr Cys Glu Thr Gln Leu Ser Pro Gln Arg Pro Asp Val Gln Leu 
    210                 215                 220                 


Gln Phe Ser Leu Phe Arg Asp Ser Gln Thr Leu Gly Leu Gly Trp Ser 
225                 230                 235                 240 


Arg Ser Pro Arg Leu Gln Ile Pro Ala Met Trp Thr Glu Asp Ser Gly 
                245                 250                 255     


Ser Tyr Trp Cys Glu Val Glu Thr Val Thr His Ser Ile Lys Lys Arg 
            260                 265                 270         


Ser Leu Arg Ser Gln Ile Arg Val Gln Arg Val Pro Val Ser Asn Val 
        275                 280                 285             


Asn Leu Glu Ile Arg Pro Thr Gly Gly Gln Leu Ile Glu Gly Glu Asn 
    290                 295                 300                 


Met Val Leu Ile Cys Ser Val Ala Gln Gly Ser Gly Thr Val Thr Phe 
305                 310                 315                 320 


Ser Trp His Lys Glu Gly Arg Val Arg Ser Leu Gly Arg Lys Thr Gln 
                325                 330                 335     


Arg Ser Leu Leu Ala Glu Leu His Val Leu Thr Val Lys Glu Ser Asp 
            340                 345                 350         


Ala Gly Arg Tyr Tyr Cys Ala Ala Asp Asn Val His Ser Pro Ile Leu 
        355                 360                 365             


Ser Thr Trp Ile Arg Val Thr Val Arg Ile Pro Val Ser His Pro Val 
    370                 375                 380                 


Leu Thr Phe Arg Ala Pro Arg Ala His Thr Val Val Gly Asp Leu Leu 
385                 390                 395                 400 


Glu Leu His Cys Glu Ser Leu Arg Gly Ser Pro Pro Ile Leu Tyr Arg 
                405                 410                 415     


Phe Tyr His Glu Asp Val Thr Leu Gly Asn Ser Ser Ala Pro Ser Gly 
            420                 425                 430         


Gly Gly Ala Ser Phe Asn Leu Ser Leu Thr Ala Glu His Ser Gly Asn 
        435                 440                 445             


Tyr Ser Cys Asp Ala Asp Asn Gly Leu Gly Ala Gln His Ser His Gly 
    450                 455                 460                 


Val Ser Leu Arg Val Thr Val Pro Val Ser Arg Pro Val Leu Thr Leu 
465                 470                 475                 480 


Arg Ala Pro Gly Ala Gln Ala Val Val Gly Asp Leu Leu Glu Leu His 
                485                 490                 495     


Cys Glu Ser Leu Arg Gly Ser Phe Pro Ile Leu Tyr Trp Phe Tyr His 
            500                 505                 510         


Glu Asp Asp Thr Leu Gly Asn Ile Ser Ala His Ser Gly Gly Gly Ala 
        515                 520                 525             


Ser Phe Asn Leu Ser Leu Thr Thr Glu His Ser Gly Asn Tyr Ser Cys 
    530                 535                 540                 


Glu Ala Asp Asn Gly Leu Gly Ala Gln His Ser Lys Val Val Thr Leu 
545                 550                 555                 560 


Asn Val Thr Gly Thr Ser Arg Asn Arg Thr Gly Leu Thr Ala Ala Gly 
                565                 570                 575     


Ile Thr Gly Leu Val Leu Ser Ile Leu Val Leu Ala Ala Ala Ala Ala 
            580                 585                 590         


Leu Leu His Tyr Ala Arg Ala Arg Arg Lys Pro Gly Gly Leu Ser Ala 
        595                 600                 605             


Thr Gly Thr Ser Ser His Ser Pro Ser Glu Cys Gln Glu Pro Ser Ser 
    610                 615                 620                 


Ser Arg Pro Ser Arg Ile Asp Pro Gln Glu Pro Thr His Ser Lys Pro 
625                 630                 635                 640 


Leu Ala Pro Met Glu Leu Glu Pro Met Tyr Ser Asn Val Asn Pro Gly 
                645                 650                 655     


Asp Ser Asn Pro Ile Tyr Ser Gln Ile Trp Ser Ile Gln His Thr Lys 
            660                 665                 670         


Glu Asn Ser Ala Asn Cys Pro Met Met His Gln Glu His Glu Glu Leu 
        675                 680                 685             


Thr Val Leu Tyr Ser Glu Leu Lys Lys Thr His Pro Asp Asp Ser Ala 
    690                 695                 700                 


Gly Glu Ala Ser Ser Arg Gly Arg Ala His Glu Glu Asp Asp Glu Glu 
705                 710                 715                 720 


Asn Tyr Glu Asn Ile Leu Asn Pro Arg Lys Asn Lys Val Gln Asp Phe 
                725                 730                 735     


Pro Cys Leu Cys Asn Thr 
            740         


<210>  454
<211>  639
<212>  PRT
<213>  Homo sapiens

<400>  454

Met Leu Leu Trp Leu Leu Leu Leu Ile Leu Thr Pro Gly Arg Glu Gln 
1               5                   10                  15      


Ser Gly Val Ala Pro Lys Ala Val Leu Leu Leu Asn Pro Pro Trp Ser 
            20                  25                  30          


Thr Ala Phe Lys Gly Glu Lys Val Ala Leu Ile Cys Ser Ser Ile Ser 
        35                  40                  45              


His Ser Leu Ala Gln Gly Asp Thr Tyr Trp Tyr His Asp Glu Lys Leu 
    50                  55                  60                  


Leu Lys Ile Lys His Asp Lys Ile Gln Ile Thr Glu Pro Gly Asn Tyr 
65                  70                  75                  80  


Gln Cys Lys Thr Arg Gly Ser Ser Leu Ser Asp Ala Val His Val Glu 
                85                  90                  95      


Phe Ser Pro Asp Trp Leu Ile Leu Gln Ala Leu His Pro Val Phe Glu 
            100                 105                 110         


Gly Asp Asn Val Ile Leu Arg Cys Gln Gly Lys Asp Asn Lys Asn Thr 
        115                 120                 125             


His Gln Lys Val Tyr Tyr Lys Asp Gly Lys Gln Leu Pro Asn Ser Tyr 
    130                 135                 140                 


Asn Leu Glu Lys Ile Thr Val Asn Ser Val Ser Arg Asp Asn Ser Lys 
145                 150                 155                 160 


Tyr His Cys Thr Ala Tyr Arg Lys Phe Tyr Ile Leu Asp Ile Glu Val 
                165                 170                 175     


Thr Ser Lys Pro Leu Asn Ile Gln Val Gln Gly Val Pro Val Ser Asn 
            180                 185                 190         


Val Asn Leu Glu Ile Arg Pro Thr Gly Gly Gln Leu Ile Glu Gly Glu 
        195                 200                 205             


Asn Met Val Leu Ile Cys Ser Val Ala Gln Gly Ser Gly Thr Val Thr 
    210                 215                 220                 


Phe Ser Trp His Lys Glu Gly Arg Val Arg Ser Leu Gly Arg Lys Thr 
225                 230                 235                 240 


Gln Arg Ser Leu Leu Ala Glu Leu His Val Leu Thr Val Lys Glu Ser 
                245                 250                 255     


Asp Ala Gly Arg Tyr Tyr Cys Ala Ala Asp Asn Val His Ser Pro Ile 
            260                 265                 270         


Leu Ser Thr Trp Ile Arg Val Thr Val Arg Ile Pro Val Ser His Pro 
        275                 280                 285             


Val Leu Thr Phe Arg Ala Pro Arg Ala His Thr Val Val Gly Asp Leu 
    290                 295                 300                 


Leu Glu Leu His Cys Glu Ser Leu Arg Gly Ser Pro Pro Ile Leu Tyr 
305                 310                 315                 320 


Arg Phe Tyr His Glu Asp Val Thr Leu Gly Asn Ser Ser Ala Pro Ser 
                325                 330                 335     


Gly Gly Gly Ala Ser Phe Asn Leu Ser Leu Thr Ala Glu His Ser Gly 
            340                 345                 350         


Asn Tyr Ser Cys Asp Ala Asp Asn Gly Leu Gly Ala Gln His Ser His 
        355                 360                 365             


Gly Val Ser Leu Arg Val Thr Val Pro Val Ser Arg Pro Val Leu Thr 
    370                 375                 380                 


Leu Arg Ala Pro Gly Ala Gln Ala Val Val Gly Asp Leu Leu Glu Leu 
385                 390                 395                 400 


His Cys Glu Ser Leu Arg Gly Ser Phe Pro Ile Leu Tyr Trp Phe Tyr 
                405                 410                 415     


His Glu Asp Asp Thr Leu Gly Asn Ile Ser Ala His Ser Gly Gly Gly 
            420                 425                 430         


Ala Ser Phe Asn Leu Ser Leu Thr Thr Glu His Ser Gly Asn Tyr Ser 
        435                 440                 445             


Cys Glu Ala Asp Asn Gly Leu Gly Ala Gln His Ser Lys Val Val Thr 
    450                 455                 460                 


Leu Asn Val Thr Gly Thr Ser Arg Asn Arg Thr Gly Leu Thr Ala Ala 
465                 470                 475                 480 


Gly Ile Thr Gly Leu Val Leu Ser Ile Leu Val Leu Ala Ala Ala Ala 
                485                 490                 495     


Ala Leu Leu His Tyr Ala Arg Ala Arg Arg Lys Pro Gly Gly Leu Ser 
            500                 505                 510         


Ala Thr Gly Thr Ser Ser His Ser Pro Ser Glu Cys Gln Glu Pro Ser 
        515                 520                 525             


Ser Ser Arg Pro Ser Arg Ile Asp Pro Gln Glu Pro Thr His Ser Lys 
    530                 535                 540                 


Pro Leu Ala Pro Met Glu Leu Glu Pro Met Tyr Ser Asn Val Asn Pro 
545                 550                 555                 560 


Gly Asp Ser Asn Pro Ile Tyr Ser Gln Ile Trp Ser Ile Gln His Thr 
                565                 570                 575     


Lys Glu Asn Ser Ala Asn Cys Pro Met Met His Gln Glu His Glu Glu 
            580                 585                 590         


Leu Thr Val Leu Tyr Ser Glu Leu Lys Lys Thr His Pro Asp Asp Ser 
        595                 600                 605             


Ala Gly Glu Ala Ser Ser Arg Gly Arg Ala His Glu Glu Asp Asp Glu 
    610                 615                 620                 


Glu Asn Tyr Glu Asn Val Pro Arg Val Leu Leu Ala Ser Asp His 
625                 630                 635                 


<210>  455
<211>  734
<212>  PRT
<213>  Homo sapiens

<400>  455

Met Leu Leu Trp Leu Leu Leu Leu Ile Leu Thr Pro Gly Arg Glu Gln 
1               5                   10                  15      


Ser Gly Val Ala Pro Lys Ala Val Leu Leu Leu Asn Pro Pro Trp Ser 
            20                  25                  30          


Thr Ala Phe Lys Gly Glu Lys Val Ala Leu Ile Cys Ser Ser Ile Ser 
        35                  40                  45              


His Ser Leu Ala Gln Gly Asp Thr Tyr Trp Tyr His Asp Glu Lys Leu 
    50                  55                  60                  


Leu Lys Ile Lys His Asp Lys Ile Gln Ile Thr Glu Pro Gly Asn Tyr 
65                  70                  75                  80  


Gln Cys Lys Thr Arg Gly Ser Ser Leu Ser Asp Ala Val His Val Glu 
                85                  90                  95      


Phe Ser Pro Asp Trp Leu Ile Leu Gln Ala Leu His Pro Val Phe Glu 
            100                 105                 110         


Gly Asp Asn Val Ile Leu Arg Cys Gln Gly Lys Asp Asn Lys Asn Thr 
        115                 120                 125             


His Gln Lys Val Tyr Tyr Lys Asp Gly Lys Gln Leu Pro Asn Ser Tyr 
    130                 135                 140                 


Asn Leu Glu Lys Ile Thr Val Asn Ser Val Ser Arg Asp Asn Ser Lys 
145                 150                 155                 160 


Tyr His Cys Thr Ala Tyr Arg Lys Phe Tyr Ile Leu Asp Ile Glu Val 
                165                 170                 175     


Thr Ser Lys Pro Leu Asn Ile Gln Val Gln Glu Leu Phe Leu His Pro 
            180                 185                 190         


Val Leu Arg Ala Ser Ser Ser Thr Pro Ile Glu Gly Ser Pro Met Thr 
        195                 200                 205             


Leu Thr Cys Glu Thr Gln Leu Ser Pro Gln Arg Pro Asp Val Gln Leu 
    210                 215                 220                 


Gln Phe Ser Leu Phe Arg Asp Ser Gln Thr Leu Gly Leu Gly Trp Ser 
225                 230                 235                 240 


Arg Ser Pro Arg Leu Gln Ile Pro Ala Met Trp Thr Glu Asp Ser Gly 
                245                 250                 255     


Ser Tyr Trp Cys Glu Val Glu Thr Val Thr His Ser Ile Lys Lys Arg 
            260                 265                 270         


Ser Leu Arg Ser Gln Ile Arg Val Gln Arg Val Pro Val Ser Asn Val 
        275                 280                 285             


Asn Leu Glu Ile Arg Pro Thr Gly Gly Gln Leu Ile Glu Gly Glu Asn 
    290                 295                 300                 


Met Val Leu Ile Cys Ser Val Ala Gln Gly Ser Gly Thr Val Thr Phe 
305                 310                 315                 320 


Ser Trp His Lys Glu Gly Arg Val Arg Ser Leu Gly Arg Lys Thr Gln 
                325                 330                 335     


Arg Ser Leu Leu Ala Glu Leu His Val Leu Thr Val Lys Glu Ser Asp 
            340                 345                 350         


Ala Gly Arg Tyr Tyr Cys Ala Ala Asp Asn Val His Ser Pro Ile Leu 
        355                 360                 365             


Ser Thr Trp Ile Arg Val Thr Val Arg Ile Pro Val Ser His Pro Val 
    370                 375                 380                 


Leu Thr Phe Arg Ala Pro Arg Ala His Thr Val Val Gly Asp Leu Leu 
385                 390                 395                 400 


Glu Leu His Cys Glu Ser Leu Arg Gly Ser Pro Pro Ile Leu Tyr Arg 
                405                 410                 415     


Phe Tyr His Glu Asp Val Thr Leu Gly Asn Ser Ser Ala Pro Ser Gly 
            420                 425                 430         


Gly Gly Ala Ser Phe Asn Leu Ser Leu Thr Ala Glu His Ser Gly Asn 
        435                 440                 445             


Tyr Ser Cys Asp Ala Asp Asn Gly Leu Gly Ala Gln His Ser His Gly 
    450                 455                 460                 


Val Ser Leu Arg Val Thr Val Pro Val Ser Arg Pro Val Leu Thr Leu 
465                 470                 475                 480 


Arg Ala Pro Gly Ala Gln Ala Val Val Gly Asp Leu Leu Glu Leu His 
                485                 490                 495     


Cys Glu Ser Leu Arg Gly Ser Phe Pro Ile Leu Tyr Trp Phe Tyr His 
            500                 505                 510         


Glu Asp Asp Thr Leu Gly Asn Ile Ser Ala His Ser Gly Gly Gly Ala 
        515                 520                 525             


Ser Phe Asn Leu Ser Leu Thr Thr Glu His Ser Gly Asn Tyr Ser Cys 
    530                 535                 540                 


Glu Ala Asp Asn Gly Leu Gly Ala Gln His Ser Lys Val Val Thr Leu 
545                 550                 555                 560 


Asn Val Thr Gly Thr Ser Arg Asn Arg Thr Gly Leu Thr Ala Ala Gly 
                565                 570                 575     


Ile Thr Gly Leu Val Leu Ser Ile Leu Val Leu Ala Ala Ala Ala Ala 
            580                 585                 590         


Leu Leu His Tyr Ala Arg Ala Arg Arg Lys Pro Gly Gly Leu Ser Ala 
        595                 600                 605             


Thr Gly Thr Ser Ser His Ser Pro Ser Glu Cys Gln Glu Pro Ser Ser 
    610                 615                 620                 


Ser Arg Pro Ser Arg Ile Asp Pro Gln Glu Pro Thr His Ser Lys Pro 
625                 630                 635                 640 


Leu Ala Pro Met Glu Leu Glu Pro Met Tyr Ser Asn Val Asn Pro Gly 
                645                 650                 655     


Asp Ser Asn Pro Ile Tyr Ser Gln Ile Trp Ser Ile Gln His Thr Lys 
            660                 665                 670         


Glu Asn Ser Ala Asn Cys Pro Met Met His Gln Glu His Glu Glu Leu 
        675                 680                 685             


Thr Val Leu Tyr Ser Glu Leu Lys Lys Thr His Pro Asp Asp Ser Ala 
    690                 695                 700                 


Gly Glu Ala Ser Ser Arg Gly Arg Ala His Glu Glu Asp Asp Glu Glu 
705                 710                 715                 720 


Asn Tyr Glu Asn Val Pro Arg Val Leu Leu Ala Ser Asp His 
                725                 730                 


<210>  456
<211>  740
<212>  PRT
<213>  Homo sapiens

<400>  456

Met Leu Leu Trp Leu Leu Leu Leu Ile Leu Thr Pro Gly Arg Glu Gln 
1               5                   10                  15      


Ser Gly Val Ala Pro Lys Ala Val Leu Leu Leu Asn Pro Pro Trp Ser 
            20                  25                  30          


Thr Ala Phe Lys Gly Glu Lys Val Ala Leu Ile Cys Ser Ser Ile Ser 
        35                  40                  45              


His Ser Leu Ala Gln Gly Asp Thr Tyr Trp Tyr His Asp Glu Lys Leu 
    50                  55                  60                  


Leu Lys Ile Lys His Asp Lys Ile Gln Ile Thr Glu Pro Gly Asn Tyr 
65                  70                  75                  80  


Gln Cys Lys Thr Arg Gly Ser Ser Leu Ser Asp Ala Val His Val Glu 
                85                  90                  95      


Phe Ser Pro Asp Trp Leu Ile Leu Gln Ala Leu His Pro Val Phe Glu 
            100                 105                 110         


Gly Asp Asn Val Ile Leu Arg Cys Gln Gly Lys Asp Asn Lys Asn Thr 
        115                 120                 125             


His Gln Lys Val Tyr Tyr Lys Asp Gly Lys Gln Leu Pro Asn Ser Tyr 
    130                 135                 140                 


Asn Leu Glu Lys Ile Thr Val Asn Ser Val Ser Arg Asp Asn Ser Lys 
145                 150                 155                 160 


Tyr His Cys Thr Ala Tyr Arg Lys Phe Tyr Ile Leu Asp Ile Glu Val 
                165                 170                 175     


Thr Ser Lys Pro Leu Asn Ile Gln Val Gln Glu Leu Phe Leu His Pro 
            180                 185                 190         


Val Leu Arg Ala Ser Ser Ser Thr Pro Ile Glu Gly Ser Pro Met Thr 
        195                 200                 205             


Leu Thr Cys Glu Thr Gln Leu Ser Pro Gln Arg Pro Asp Val Gln Leu 
    210                 215                 220                 


Gln Phe Ser Leu Phe Arg Asp Ser Gln Thr Leu Gly Leu Gly Trp Ser 
225                 230                 235                 240 


Arg Ser Pro Arg Leu Gln Ile Pro Ala Met Trp Thr Glu Asp Ser Gly 
                245                 250                 255     


Ser Tyr Trp Cys Glu Val Glu Thr Val Thr His Ser Ile Lys Lys Arg 
            260                 265                 270         


Ser Leu Arg Ser Gln Ile Arg Val Gln Arg Val Pro Val Ser Asn Val 
        275                 280                 285             


Asn Leu Glu Ile Arg Pro Thr Gly Gly Gln Leu Ile Glu Gly Glu Asn 
    290                 295                 300                 


Met Val Leu Ile Cys Ser Val Ala Gln Gly Ser Gly Thr Val Thr Phe 
305                 310                 315                 320 


Ser Trp His Lys Glu Gly Arg Val Arg Ser Leu Gly Arg Lys Thr Gln 
                325                 330                 335     


Arg Ser Leu Leu Ala Glu Leu His Val Leu Thr Val Lys Glu Ser Asp 
            340                 345                 350         


Ala Gly Arg Tyr Tyr Cys Ala Ala Asp Asn Val His Ser Pro Ile Leu 
        355                 360                 365             


Ser Thr Trp Ile Arg Val Thr Val Arg Thr Leu Leu Ser Pro Ser Val 
    370                 375                 380                 


Pro Val Ser His Pro Val Leu Thr Phe Arg Ala Pro Arg Ala His Thr 
385                 390                 395                 400 


Val Val Gly Asp Leu Leu Glu Leu His Cys Glu Ser Leu Arg Gly Ser 
                405                 410                 415     


Pro Pro Ile Leu Tyr Arg Phe Tyr His Glu Asp Val Thr Leu Gly Asn 
            420                 425                 430         


Ser Ser Ala Pro Ser Gly Gly Gly Ala Ser Phe Asn Leu Ser Leu Thr 
        435                 440                 445             


Ala Glu His Ser Gly Asn Tyr Ser Cys Asp Ala Asp Asn Gly Leu Gly 
    450                 455                 460                 


Ala Gln His Ser His Gly Val Ser Leu Arg Val Thr Val Pro Val Ser 
465                 470                 475                 480 


Arg Pro Val Leu Thr Leu Arg Ala Pro Gly Ala Gln Ala Val Val Gly 
                485                 490                 495     


Asp Leu Leu Glu Leu His Cys Glu Ser Leu Arg Gly Ser Phe Pro Ile 
            500                 505                 510         


Leu Tyr Trp Phe Tyr His Glu Asp Asp Thr Leu Gly Asn Ile Ser Ala 
        515                 520                 525             


His Ser Gly Gly Gly Ala Ser Phe Asn Leu Ser Leu Thr Thr Glu His 
    530                 535                 540                 


Ser Gly Asn Tyr Ser Cys Glu Ala Asp Asn Gly Leu Gly Ala Gln His 
545                 550                 555                 560 


Ser Lys Val Val Thr Leu Asn Val Thr Gly Thr Ser Arg Asn Arg Thr 
                565                 570                 575     


Gly Leu Thr Ala Ala Gly Ile Thr Gly Leu Val Leu Ser Ile Leu Val 
            580                 585                 590         


Leu Ala Ala Ala Ala Ala Leu Leu His Tyr Ala Arg Ala Arg Arg Lys 
        595                 600                 605             


Pro Gly Gly Leu Ser Ala Thr Gly Thr Ser Ser His Ser Pro Ser Glu 
    610                 615                 620                 


Cys Gln Glu Pro Ser Ser Ser Arg Pro Ser Arg Ile Asp Pro Gln Glu 
625                 630                 635                 640 


Pro Thr His Ser Lys Pro Leu Ala Pro Met Glu Leu Glu Pro Met Tyr 
                645                 650                 655     


Ser Asn Val Asn Pro Gly Asp Ser Asn Pro Ile Tyr Ser Gln Ile Trp 
            660                 665                 670         


Ser Ile Gln His Thr Lys Glu Asn Ser Ala Asn Cys Pro Met Met His 
        675                 680                 685             


Gln Glu His Glu Glu Leu Thr Val Leu Tyr Ser Glu Leu Lys Lys Thr 
    690                 695                 700                 


His Pro Asp Asp Ser Ala Gly Glu Ala Ser Ser Arg Gly Arg Ala His 
705                 710                 715                 720 


Glu Glu Asp Asp Glu Glu Asn Tyr Glu Asn Val Pro Arg Val Leu Leu 
                725                 730                 735     


Ala Ser Asp His 
            740 


<210>  457
<211>  256
<212>  PRT
<213>  Homo sapiens

<400>  457

Met Leu Leu Trp Leu Leu Leu Leu Ile Leu Thr Pro Gly Arg Glu Gln 
1               5                   10                  15      


Ser Gly Val Ala Pro Lys Ala Val Leu Leu Leu Asn Pro Pro Trp Ser 
            20                  25                  30          


Thr Ala Phe Lys Gly Glu Lys Val Ala Leu Ile Cys Ser Ser Ile Ser 
        35                  40                  45              


His Ser Leu Ala Gln Gly Asp Thr Tyr Trp Tyr His Asp Glu Lys Leu 
    50                  55                  60                  


Leu Lys Ile Lys His Asp Lys Ile Gln Ile Thr Glu Pro Gly Asn Tyr 
65                  70                  75                  80  


Gln Cys Lys Thr Arg Gly Ser Ser Leu Ser Asp Ala Val His Val Glu 
                85                  90                  95      


Phe Ser Pro Asp Trp Leu Ile Leu Gln Ala Leu His Pro Val Phe Glu 
            100                 105                 110         


Gly Asp Asn Val Ile Leu Arg Cys Gln Gly Lys Asp Asn Lys Asn Thr 
        115                 120                 125             


His Gln Lys Val Tyr Tyr Lys Asp Gly Lys Gln Leu Pro Asn Ser Tyr 
    130                 135                 140                 


Asn Leu Glu Lys Ile Thr Val Asn Ser Val Ser Arg Asp Asn Ser Lys 
145                 150                 155                 160 


Tyr His Cys Thr Ala Tyr Arg Lys Phe Tyr Ile Leu Asp Ile Glu Val 
                165                 170                 175     


Thr Ser Lys Pro Leu Asn Ile Gln Val Gln Glu Leu Phe Leu His Pro 
            180                 185                 190         


Val Leu Arg Ala Ser Ser Ser Thr Pro Ile Glu Gly Ser Pro Met Thr 
        195                 200                 205             


Leu Thr Cys Glu Thr Gln Leu Ser Pro Gln Arg Pro Asp Val Gln Leu 
    210                 215                 220                 


Gln Phe Ser Leu Phe Arg Asp Ser Gln Thr Leu Gly Leu Gly Trp Ser 
225                 230                 235                 240 


Arg Ser Pro Arg Leu Gln Ile Pro Ala Met Trp Thr Glu Asp Ser Gly 
                245                 250                 255     


<210>  458
<211>  234
<212>  PRT
<213>  Homo sapiens

<400>  458

Met Ala Phe Leu Ala Gly Pro Arg Leu Leu Asp Trp Ala Ser Ser Pro 
1               5                   10                  15      


Pro His Leu Gln Phe Asn Lys Phe Val Leu Thr Gly Tyr Arg Pro Ala 
            20                  25                  30          


Ser Ser Gly Ser Gly Cys Leu Arg Ser Leu Phe Tyr Leu His Asn Glu 
        35                  40                  45              


Leu Gly Asn Ile Tyr Thr His Gly Ser Val Leu Tyr His Leu Phe Met 
    50                  55                  60                  


Cys His Gln Gly Gly Ser Ala Val Tyr Ala Arg Leu Leu Ala Leu Asp 
65                  70                  75                  80  


Met Cys Gly Val Cys Leu Val Asn Thr Leu Gly Ala Leu Pro Ile Ile 
                85                  90                  95      


His Cys Thr Leu Ala Cys Arg Pro Trp Leu Arg Pro Ala Ala Leu Val 
            100                 105                 110         


Gly Tyr Thr Val Leu Ser Gly Val Ala Gly Trp Arg Ala Leu Thr Ala 
        115                 120                 125             


Pro Ser Thr Ser Ala Arg Leu Arg Ala Phe Gly Trp Gln Ala Ala Ala 
    130                 135                 140                 


Arg Leu Leu Val Phe Gly Ala Arg Gly Val Gly Leu Gly Ser Gly Ala 
145                 150                 155                 160 


Pro Gly Ser Leu Pro Cys Tyr Leu Arg Met Asp Ala Leu Ala Leu Leu 
                165                 170                 175     


Gly Gly Leu Val Asn Val Ala Arg Leu Pro Glu Arg Trp Gly Pro Gly 
            180                 185                 190         


Arg Phe Asp Tyr Trp Gly Asn Ser His Gln Ile Met His Leu Leu Ser 
        195                 200                 205             


Val Gly Ser Ile Leu Gln Leu His Ala Gly Val Val Pro Asp Leu Leu 
    210                 215                 220                 


Trp Ala Ala His His Ala Cys Pro Arg Asp 
225                 230                 


<210>  459
<211>  273
<212>  PRT
<213>  Homo sapiens

<400>  459

Met Ala Phe Leu Ala Gly Pro Arg Leu Leu Asp Trp Ala Ser Ser Pro 
1               5                   10                  15      


Pro His Leu Gln Phe Asn Lys Phe Val Leu Thr Gly Tyr Arg Pro Ala 
            20                  25                  30          


Ser Ser Gly Ser Gly Cys Leu Arg Ser Leu Phe Tyr Leu His Asn Glu 
        35                  40                  45              


Leu Gly Asn Ile Tyr Thr His Gly Leu Ala Leu Leu Gly Phe Leu Val 
    50                  55                  60                  


Leu Val Pro Met Thr Met Pro Trp Gly Gln Leu Gly Lys Asp Gly Trp 
65                  70                  75                  80  


Leu Gly Gly Thr His Cys Val Ala Cys Leu Ala Pro Pro Ala Gly Ser 
                85                  90                  95      


Val Leu Tyr His Leu Phe Met Cys His Gln Gly Gly Ser Ala Val Tyr 
            100                 105                 110         


Ala Arg Leu Leu Ala Leu Asp Met Cys Gly Val Cys Leu Val Asn Thr 
        115                 120                 125             


Leu Gly Ala Leu Pro Ile Ile His Cys Thr Leu Ala Cys Arg Pro Trp 
    130                 135                 140                 


Leu Arg Pro Ala Ala Leu Val Gly Tyr Thr Val Leu Ser Gly Val Ala 
145                 150                 155                 160 


Gly Trp Arg Ala Leu Thr Ala Pro Ser Thr Ser Ala Arg Leu Arg Ala 
                165                 170                 175     


Phe Gly Trp Gln Ala Ala Ala Arg Leu Leu Val Phe Gly Ala Arg Gly 
            180                 185                 190         


Val Gly Leu Gly Ser Gly Ala Pro Gly Ser Leu Pro Cys Tyr Leu Arg 
        195                 200                 205             


Met Asp Ala Leu Ala Leu Leu Gly Gly Leu Val Asn Val Ala Arg Leu 
    210                 215                 220                 


Pro Glu Arg Trp Gly Pro Gly Arg Phe Asp Tyr Trp Gly Asn Ser His 
225                 230                 235                 240 


Gln Ile Met His Leu Leu Ser Val Gly Ser Ile Leu Gln Leu His Ala 
                245                 250                 255     


Gly Val Val Pro Asp Leu Leu Trp Ala Ala His His Ala Cys Pro Arg 
            260                 265                 270         


Asp 
    


<210>  460
<211>  199
<212>  PRT
<213>  Homo sapiens

<400>  460

Met Ala Phe Leu Ala Gly Pro Arg Leu Leu Asp Trp Ala Ser Ser Pro 
1               5                   10                  15      


Pro His Leu Gln Phe Asn Lys Phe Val Leu Thr Gly Tyr Arg Pro Ala 
            20                  25                  30          


Ser Ser Gly Ser Gly Cys Leu Arg Ser Leu Phe Tyr Leu His Asn Glu 
        35                  40                  45              


Leu Gly Asn Ile Tyr Thr His Gly Ala Leu Pro Ile Ile His Cys Thr 
    50                  55                  60                  


Leu Ala Cys Arg Pro Trp Leu Arg Pro Ala Ala Leu Val Gly Tyr Thr 
65                  70                  75                  80  


Val Leu Ser Gly Val Ala Gly Trp Arg Ala Leu Thr Ala Pro Ser Thr 
                85                  90                  95      


Ser Ala Arg Leu Arg Ala Phe Gly Trp Gln Ala Ala Ala Arg Leu Leu 
            100                 105                 110         


Val Phe Gly Ala Arg Gly Val Gly Leu Gly Ser Gly Ala Pro Gly Ser 
        115                 120                 125             


Leu Pro Cys Tyr Leu Arg Met Asp Ala Leu Ala Leu Leu Gly Gly Leu 
    130                 135                 140                 


Val Asn Val Ala Arg Leu Pro Glu Arg Trp Gly Pro Gly Arg Phe Asp 
145                 150                 155                 160 


Tyr Trp Gly Asn Ser His Gln Ile Met His Leu Leu Ser Val Gly Ser 
                165                 170                 175     


Ile Leu Gln Leu His Ala Gly Val Val Pro Asp Leu Leu Trp Ala Ala 
            180                 185                 190         


His His Ala Cys Pro Arg Asp 
        195                 


<210>  461
<211>  206
<212>  PRT
<213>  Homo sapiens

<400>  461

Met Thr Met Pro Trp Gly Gln Leu Gly Lys Asp Gly Trp Leu Gly Gly 
1               5                   10                  15      


Thr His Cys Val Ala Cys Leu Ala Pro Pro Ala Gly Ser Val Leu Tyr 
            20                  25                  30          


His Leu Phe Met Cys His Gln Gly Gly Ser Ala Val Tyr Ala Arg Leu 
        35                  40                  45              


Leu Ala Leu Asp Met Cys Gly Val Cys Leu Val Asn Thr Leu Gly Ala 
    50                  55                  60                  


Leu Pro Ile Ile His Cys Thr Leu Ala Cys Arg Pro Trp Leu Arg Pro 
65                  70                  75                  80  


Ala Ala Leu Val Gly Tyr Thr Val Leu Ser Gly Val Ala Gly Trp Arg 
                85                  90                  95      


Ala Leu Thr Ala Pro Ser Thr Ser Ala Arg Leu Arg Ala Phe Gly Trp 
            100                 105                 110         


Gln Ala Ala Ala Arg Leu Leu Val Phe Gly Ala Arg Gly Val Gly Leu 
        115                 120                 125             


Gly Ser Gly Ala Pro Gly Ser Leu Pro Cys Tyr Leu Arg Met Asp Ala 
    130                 135                 140                 


Leu Ala Leu Leu Gly Gly Leu Val Asn Val Ala Arg Leu Pro Glu Arg 
145                 150                 155                 160 


Trp Gly Pro Gly Arg Phe Asp Tyr Trp Gly Asn Ser His Gln Ile Met 
                165                 170                 175     


His Leu Leu Ser Val Gly Ser Ile Leu Gln Leu His Ala Gly Val Val 
            180                 185                 190         


Pro Asp Leu Leu Trp Ala Ala His His Ala Cys Pro Arg Asp 
        195                 200                 205     


<210>  462
<211>  206
<212>  PRT
<213>  Homo sapiens

<400>  462

Met Thr Met Pro Trp Gly Gln Leu Gly Lys Asp Gly Trp Leu Gly Gly 
1               5                   10                  15      


Thr His Cys Val Ala Cys Leu Ala Pro Pro Ala Gly Ser Val Leu Tyr 
            20                  25                  30          


His Leu Phe Met Cys His Gln Gly Gly Ser Ala Val Tyr Ala Arg Leu 
        35                  40                  45              


Leu Ala Leu Asp Met Cys Gly Val Cys Leu Val Asn Thr Leu Gly Ala 
    50                  55                  60                  


Leu Pro Ile Ile His Cys Thr Leu Ala Cys Arg Pro Trp Leu Arg Pro 
65                  70                  75                  80  


Ala Ala Leu Val Gly Tyr Thr Val Leu Ser Gly Val Ala Gly Trp Arg 
                85                  90                  95      


Ala Leu Thr Ala Pro Ser Thr Ser Ala Arg Leu Arg Ala Phe Gly Trp 
            100                 105                 110         


Gln Ala Ala Ala Arg Leu Leu Val Phe Gly Ala Arg Gly Val Gly Leu 
        115                 120                 125             


Gly Ser Gly Ala Pro Gly Ser Leu Pro Cys Tyr Leu Arg Met Asp Ala 
    130                 135                 140                 


Leu Ala Leu Leu Gly Gly Leu Val Asn Val Ala Arg Leu Pro Glu Arg 
145                 150                 155                 160 


Trp Gly Pro Gly Arg Phe Asp Tyr Trp Gly Asn Ser His Gln Ile Met 
                165                 170                 175     


His Leu Leu Ser Val Gly Ser Ile Leu Gln Leu His Ala Gly Val Val 
            180                 185                 190         


Pro Asp Leu Leu Trp Ala Ala His His Ala Cys Pro Arg Asp 
        195                 200                 205     


<210>  463
<211>  208
<212>  PRT
<213>  Homo sapiens

<400>  463

Met Gly Ala Gln Gly Ala Gln Glu Ser Ile Lys Ala Met Trp Arg Val 
1               5                   10                  15      


Pro Gly Thr Thr Arg Arg Pro Val Thr Gly Glu Ser Pro Gly Met His 
            20                  25                  30          


Arg Pro Glu Ala Met Leu Leu Leu Leu Thr Leu Ala Leu Leu Gly Gly 
        35                  40                  45              


Pro Thr Trp Ala Gly Lys Met Tyr Gly Pro Gly Gly Gly Lys Tyr Phe 
    50                  55                  60                  


Ser Thr Thr Glu Asp Tyr Asp His Glu Ile Thr Gly Leu Arg Val Ser 
65                  70                  75                  80  


Val Gly Leu Leu Leu Val Lys Ser Val Gln Val Lys Leu Gly Asp Ser 
                85                  90                  95      


Trp Asp Val Lys Leu Gly Ala Leu Gly Gly Asn Thr Gln Glu Val Thr 
            100                 105                 110         


Leu Gln Pro Gly Glu Tyr Ile Thr Lys Val Phe Val Ala Phe Gln Ala 
        115                 120                 125             


Phe Leu Arg Gly Met Val Met Tyr Thr Ser Lys Asp Arg Tyr Phe Tyr 
    130                 135                 140                 


Phe Gly Lys Leu Asp Gly Gln Ile Ser Ser Ala Tyr Pro Ser Gln Glu 
145                 150                 155                 160 


Gly Gln Val Leu Val Gly Ile Tyr Gly Gln Tyr Gln Leu Leu Gly Ile 
                165                 170                 175     


Lys Ser Ile Gly Phe Glu Trp Asn Tyr Pro Leu Glu Glu Pro Thr Thr 
            180                 185                 190         


Glu Pro Pro Val Asn Leu Thr Tyr Ser Ala Asn Ser Pro Val Gly Arg 
        195                 200                 205             


<210>  464
<211>  95
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  464

Xaa Ala Gln Gly Ala Gln Glu Ser Ile Lys Ala Met Trp Arg Val Pro 
1               5                   10                  15      


Gly Thr Thr Arg Arg Pro Val Thr Gly Glu Ser Pro Gly Met His Arg 
            20                  25                  30          


Pro Glu Ala Met Leu Leu Leu Leu Thr Leu Ala Leu Leu Gly Gly Pro 
        35                  40                  45              


Thr Trp Ala Gly Lys Met Tyr Gly Pro Gly Gly Gly Lys Tyr Phe Ser 
    50                  55                  60                  


Thr Thr Glu Asp Tyr Asp His Glu Ile Thr Gly Leu Arg Val Ser Val 
65                  70                  75                  80  


Gly Leu Leu Leu Val Lys Arg Phe Leu Glu Gly Val Ile Tyr Glu 
                85                  90                  95  


<210>  465
<211>  69
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  465

Xaa Arg Arg Pro Val Thr Gly Glu Ser Pro Gly Met His Arg Pro Glu 
1               5                   10                  15      


Ala Met Leu Leu Leu Leu Thr Leu Ala Leu Leu Gly Gly Pro Thr Trp 
            20                  25                  30          


Ala Gly Lys Met Tyr Gly Pro Gly Gly Gly Lys Tyr Phe Ser Thr Thr 
        35                  40                  45              


Glu Asp Tyr Asp His Glu Ile Thr Gly Leu Arg Val Ser Val Gly Leu 
    50                  55                  60                  


Leu Leu Val Lys Arg 
65                  


<210>  466
<211>  178
<212>  PRT
<213>  Homo sapiens

<400>  466

Met His Arg Pro Glu Ala Met Leu Leu Leu Leu Thr Leu Ala Leu Leu 
1               5                   10                  15      


Gly Gly Pro Thr Trp Ala Gly Lys Met Tyr Gly Pro Gly Gly Gly Lys 
            20                  25                  30          


Tyr Phe Ser Thr Thr Glu Asp Tyr Asp His Glu Ile Thr Gly Leu Arg 
        35                  40                  45              


Val Ser Val Gly Leu Leu Leu Val Lys Ser Val Gln Val Lys Leu Gly 
    50                  55                  60                  


Asp Ser Trp Asp Val Lys Leu Gly Ala Leu Gly Gly Asn Thr Gln Glu 
65                  70                  75                  80  


Val Thr Leu Gln Pro Gly Glu Tyr Ile Thr Lys Val Phe Val Ala Phe 
                85                  90                  95      


Gln Ala Phe Leu Arg Gly Met Val Met Tyr Thr Ser Lys Asp Arg Tyr 
            100                 105                 110         


Phe Tyr Phe Gly Lys Leu Asp Gly Gln Ile Ser Ser Ala Tyr Pro Ser 
        115                 120                 125             


Gln Glu Gly Gln Val Leu Val Gly Ile Tyr Gly Gln Tyr Gln Leu Leu 
    130                 135                 140                 


Gly Ile Lys Ser Ile Gly Phe Glu Trp Asn Tyr Pro Leu Glu Glu Pro 
145                 150                 155                 160 


Thr Thr Glu Pro Pro Val Asn Leu Thr Tyr Ser Ala Asn Ser Pro Val 
                165                 170                 175     


Gly Arg 
        


<210>  467
<211>  399
<212>  PRT
<213>  Homo sapiens

<400>  467

Met Ala Glu Leu Leu Arg Ser Leu Gln Asp Ser Gln Leu Val Ala Arg 
1               5                   10                  15      


Phe Gln Arg Arg Cys Gly Leu Phe Pro Ala Pro Asp Glu Gly Pro Arg 
            20                  25                  30          


Glu Asn Gly Ala Asp Pro Thr Glu Arg Ala Ala Arg Val Pro Gly Val 
        35                  40                  45              


Glu His Leu Pro Ala Ala Asn Gly Lys Gly Gly Glu Ala Pro Ala Asn 
    50                  55                  60                  


Gly Leu Arg Arg Ala Ala Ala Pro Glu Ala Tyr Val Gln Lys Tyr Val 
65                  70                  75                  80  


Val Lys Asn Tyr Phe Tyr Tyr Tyr Leu Phe Gln Phe Ser Ala Ala Leu 
                85                  90                  95      


Gly Gln Glu Val Phe Tyr Ile Thr Phe Leu Pro Phe Thr His Trp Asn 
            100                 105                 110         


Ile Asp Pro Tyr Leu Ser Arg Arg Leu Ile Ile Ile Trp Val Leu Val 
        115                 120                 125             


Met Tyr Ile Gly Gln Val Ala Lys Asp Val Leu Lys Trp Pro Arg Pro 
    130                 135                 140                 


Ser Ser Pro Pro Val Val Lys Leu Glu Lys Arg Leu Ile Ala Glu Tyr 
145                 150                 155                 160 


Gly Met Pro Ser Thr His Ala Met Ala Ala Thr Ala Ile Ala Phe Thr 
                165                 170                 175     


Leu Leu Ile Ser Thr Met Asp Arg Tyr Gln Tyr Pro Phe Val Leu Gly 
            180                 185                 190         


Leu Val Met Ala Val Val Phe Ser Thr Leu Val Cys Leu Ser Arg Leu 
        195                 200                 205             


Tyr Thr Gly Met His Thr Val Leu Asp Val Leu Gly Gly Val Leu Ile 
    210                 215                 220                 


Thr Ala Leu Leu Ile Val Leu Thr Tyr Pro Ala Trp Thr Phe Ile Asp 
225                 230                 235                 240 


Cys Leu Asp Ser Ala Ser Pro Leu Phe Pro Val Cys Val Ile Val Val 
                245                 250                 255     


Pro Phe Phe Leu Cys Tyr Asn Tyr Pro Val Ser Asp Tyr Tyr Ser Pro 
            260                 265                 270         


Thr Arg Ala Asp Thr Thr Thr Ile Leu Ala Ala Gly Ala Gly Val Thr 
        275                 280                 285             


Ile Gly Phe Trp Ile Asn His Phe Phe Gln Leu Val Ser Lys Pro Ala 
    290                 295                 300                 


Glu Ser Leu Pro Val Ile Gln Asn Ile Pro Pro Leu Thr Thr Tyr Met 
305                 310                 315                 320 


Leu Val Leu Gly Leu Thr Lys Phe Ala Val Gly Ile Val Leu Ile Leu 
                325                 330                 335     


Leu Val Arg Gln Leu Val Gln Asn Leu Ser Leu Gln Val Leu Tyr Ser 
            340                 345                 350         


Trp Phe Lys Val Val Thr Arg Asn Lys Glu Ala Arg Arg Arg Leu Glu 
        355                 360                 365             


Ile Glu Val Pro Tyr Lys Phe Val Thr Tyr Thr Ser Val Gly Ile Cys 
    370                 375                 380                 


Ala Thr Thr Phe Val Pro Met Leu His Arg Phe Leu Gly Leu Pro 
385                 390                 395                 


<210>  468
<211>  128
<212>  PRT
<213>  Homo sapiens

<400>  468

Met Asp Val Tyr Gly Thr Thr Lys Ala Ile Glu Leu Leu Asp Pro Thr 
1               5                   10                  15      


Ala Ser Arg Leu Pro Thr Pro Met Pro Trp Asp Leu Ser Asn Lys Ala 
            20                  25                  30          


Val Pro Glu Pro Lys Gly Phe Gly Pro Lys Asp Leu Ala Leu Pro Thr 
        35                  40                  45              


Gly Asn Leu Lys Ala Thr Trp His Leu Cys Leu Arg Glu His Leu Pro 
    50                  55                  60                  


Thr Leu His Thr Arg Arg Gly Val Cys His Leu Leu Leu Ser Arg Cys 
65                  70                  75                  80  


Gln His Pro Pro Cys Ala Leu Arg Pro His Ile Leu Leu Gln Ile Leu 
                85                  90                  95      


Cys Leu Ala Gly Leu Gln Arg Tyr Gly Gln Val Pro Cys Val Pro Leu 
            100                 105                 110         


Ala Asp Arg Gly Gly Ser Pro Cys Ala Gly Pro Ser Cys Ser Glu Gly 
        115                 120                 125             


<210>  469
<211>  104
<212>  PRT
<213>  Homo sapiens

<400>  469

Met Asp Val Tyr Gly Thr Thr Lys Ala Ile Glu Leu Leu Asp Pro Thr 
1               5                   10                  15      


Ala Ser Arg Leu Pro Thr Pro Met Pro Trp Asp Leu Ser Asn Lys Ala 
            20                  25                  30          


Val Pro Glu Pro Lys Ala Thr Pro Gly Glu Glu Cys Ala Ile Cys Phe 
        35                  40                  45              


Tyr His Ala Ala Asn Thr Arg Leu Val Pro Cys Gly His Thr Tyr Phe 
    50                  55                  60                  


Cys Arg Tyr Cys Ala Trp Arg Val Phe Ser Asp Thr Ala Lys Cys Pro 
65                  70                  75                  80  


Val Cys Arg Trp Gln Ile Glu Ala Val Ala Pro Ala Gln Gly Pro Pro 
                85                  90                  95      


Ala Leu Arg Val Glu Glu Gly Ser 
            100                 


<210>  470
<211>  83
<212>  PRT
<213>  Homo sapiens

<400>  470

Met Ala Pro Gly Cys Lys Ile Met Lys Val Met Pro Ser Lys Phe Leu 
1               5                   10                  15      


Cys Glu Phe Val Leu Leu Gln Lys Asp Leu Gly Gln Leu Met Glu Ser 
            20                  25                  30          


Arg Thr Tyr Ala Tyr Leu Cys Cys Pro Pro Arg Val Ser Gly Cys Thr 
        35                  40                  45              


Pro Thr Leu Ser Pro Arg Pro Ser Arg Leu Ile Met Leu Gln Met Trp 
    50                  55                  60                  


Ile Pro Leu Arg Asn Leu Tyr Ser Gln Leu Trp Leu Lys Ala Leu Trp 
65                  70                  75                  80  


Ser Leu Ala 
            


<210>  471
<211>  438
<212>  PRT
<213>  Homo sapiens

<400>  471

Met Pro Cys Thr Cys Thr Trp Arg Asn Trp Arg Gln Trp Ile Arg Pro 
1               5                   10                  15      


Leu Val Ala Val Ile Tyr Leu Val Ser Ile Val Val Ala Val Pro Leu 
            20                  25                  30          


Cys Val Trp Glu Leu Gln Lys Leu Glu Val Gly Ile His Thr Lys Ala 
        35                  40                  45              


Trp Phe Ile Ala Gly Ile Phe Leu Leu Leu Thr Ile Pro Ile Ser Leu 
    50                  55                  60                  


Trp Val Ile Leu Gln His Leu Val His Tyr Thr Gln Pro Glu Leu Gln 
65                  70                  75                  80  


Lys Pro Ile Ile Arg Ile Leu Trp Met Val Pro Ile Tyr Ser Leu Asp 
                85                  90                  95      


Ser Trp Ile Ala Leu Lys Tyr Pro Gly Ile Ala Ile Tyr Val Asp Thr 
            100                 105                 110         


Cys Arg Glu Cys Tyr Glu Ala Tyr Val Ile Tyr Asn Phe Met Gly Phe 
        115                 120                 125             


Leu Thr Asn Tyr Leu Thr Asn Arg Tyr Pro Asn Leu Val Leu Ile Leu 
    130                 135                 140                 


Glu Ala Lys Asp Gln Gln Lys His Phe Pro Pro Leu Cys Cys Cys Pro 
145                 150                 155                 160 


Pro Trp Ala Met Gly Glu Val Leu Leu Phe Arg Cys Lys Leu Gly Val 
                165                 170                 175     


Leu Gln Tyr Thr Val Val Arg Pro Phe Thr Thr Ile Val Ala Leu Ile 
            180                 185                 190         


Cys Glu Leu Leu Gly Ile Tyr Asp Glu Gly Asn Phe Ser Phe Ser Asn 
        195                 200                 205             


Ala Trp Thr Tyr Leu Val Ile Ile Asn Asn Met Ser Gln Leu Phe Ala 
    210                 215                 220                 


Met Tyr Cys Leu Leu Leu Phe Tyr Lys Val Leu Lys Glu Glu Leu Ser 
225                 230                 235                 240 


Pro Ile Gln Pro Val Gly Lys Phe Leu Cys Val Lys Leu Val Val Phe 
                245                 250                 255     


Val Ser Phe Trp Gln Ala Val Val Ile Ala Leu Leu Val Lys Val Gly 
            260                 265                 270         


Val Ile Ser Glu Lys His Thr Trp Glu Trp Gln Thr Val Glu Ala Val 
        275                 280                 285             


Ala Thr Gly Leu Gln Asp Phe Ile Ile Cys Ile Glu Met Phe Leu Ala 
    290                 295                 300                 


Ala Ile Ala His His Tyr Thr Phe Ser Tyr Lys Pro Tyr Val Gln Glu 
305                 310                 315                 320 


Ala Glu Glu Gly Ser Cys Phe Asp Ser Phe Leu Ala Met Trp Asp Val 
                325                 330                 335     


Ser Asp Ile Arg Asp Asp Ile Ser Glu Gln Val Arg His Val Gly Arg 
            340                 345                 350         


Thr Val Arg Gly His Pro Arg Lys Lys Leu Phe Pro Glu Asp Gln Asp 
        355                 360                 365             


Gln Asn Glu His Thr Ser Leu Leu Ser Ser Ser Ser Gln Asp Ala Ile 
    370                 375                 380                 


Ser Ile Ala Ser Ser Met Pro Pro Ser Pro Met Gly His Tyr Gln Gly 
385                 390                 395                 400 


Phe Gly His Thr Val Thr Pro Gln Thr Thr Pro Thr Thr Ala Lys Ile 
                405                 410                 415     


Ser Asp Glu Ile Leu Ser Asp Thr Ile Gly Glu Lys Lys Glu Pro Ser 
            420                 425                 430         


Asp Lys Ser Val Asp Ser 
        435             


<210>  472
<211>  72
<212>  PRT
<213>  Homo sapiens

<400>  472

Leu Gly Ile Tyr Asp Glu Gly Asn Phe Ser Phe Ser Asn Ala Trp Thr 
1               5                   10                  15      


Tyr Leu Val Ile Ile Asn Asn Met Ser Gln Leu Phe Ala Met Tyr Cys 
            20                  25                  30          


Leu Leu Leu Phe Tyr Lys Val Leu Lys Glu Glu Leu Ser Pro Ile Gln 
        35                  40                  45              


Pro Val Gly Lys Phe Leu Cys Val Lys Leu Val Val Phe Val Ser Phe 
    50                  55                  60                  


Cys Ile Arg Gly Asn Gly Lys Leu 
65                  70          


<210>  473
<211>  261
<212>  PRT
<213>  Homo sapiens

<400>  473

Met Pro Cys Thr Cys Thr Trp Arg Asn Trp Arg Gln Trp Ile Arg Pro 
1               5                   10                  15      


Leu Val Ala Val Ile Tyr Leu Val Ser Ile Val Val Ala Val Pro Leu 
            20                  25                  30          


Cys Val Trp Glu Leu Gln Lys Leu Glu Val Gly Ile His Thr Lys Ala 
        35                  40                  45              


Trp Phe Ile Ala Gly Ile Phe Leu Leu Leu Thr Ile Pro Ile Ser Leu 
    50                  55                  60                  


Trp Val Ile Leu Gln His Leu Val His Tyr Thr Gln Pro Glu Leu Gln 
65                  70                  75                  80  


Lys Pro Ile Ile Arg Ile Leu Trp Met Val Pro Ile Tyr Ser Leu Asp 
                85                  90                  95      


Ser Trp Ile Ala Leu Lys Tyr Pro Gly Ile Ala Ile Tyr Val Asp Thr 
            100                 105                 110         


Cys Arg Glu Cys Tyr Glu Ala Tyr Val Ile Tyr Asn Phe Met Gly Phe 
        115                 120                 125             


Leu Thr Asn Tyr Leu Thr Asn Arg Tyr Pro Asn Leu Val Leu Ile Leu 
    130                 135                 140                 


Glu Ala Lys Asp Gln Gln Lys His Phe Pro Pro Leu Cys Cys Cys Pro 
145                 150                 155                 160 


Pro Trp Ala Met Gly Glu Val Leu Leu Phe Arg Cys Lys Leu Gly Val 
                165                 170                 175     


Leu Gln Tyr Thr Val Val Arg Pro Phe Thr Thr Ile Val Ala Leu Ile 
            180                 185                 190         


Cys Glu Leu Leu Gly Ile Tyr Asp Glu Gly Asn Phe Ser Phe Ser Asn 
        195                 200                 205             


Ala Trp Thr Tyr Leu Val Ile Ile Asn Asn Met Ser Gln Leu Phe Ala 
    210                 215                 220                 


Met Tyr Cys Leu Leu Leu Phe Tyr Lys Val Leu Lys Glu Glu Leu Ser 
225                 230                 235                 240 


Pro Ile Gln Pro Val Gly Lys Phe Leu Cys Val Lys Leu Val Val Phe 
                245                 250                 255     


Val Ser Phe Trp Pro 
            260     


<210>  474
<211>  115
<212>  PRT
<213>  Homo sapiens

<400>  474

Met Leu Trp Phe Gln Gly Asn Ser Met Gln Leu Ala Arg Ser Ser Phe 
1               5                   10                  15      


Gly Leu Phe Leu Arg Asn Cys Ser Ala Ser Lys Thr Thr Leu Pro Val 
            20                  25                  30          


Leu Thr Leu Phe Thr Lys Asp Pro Cys Pro Leu Cys Asp Glu Ala Lys 
        35                  40                  45              


Glu Val Leu Lys Pro Tyr Glu Asn Arg Phe Ile Leu Gln Glu Val Asn 
    50                  55                  60                  


Ile Thr Leu Pro Glu Asn Ser Val Trp Tyr Glu Arg Tyr Lys Phe Asp 
65                  70                  75                  80  


Ile Pro Val Phe His Leu Asn Gly Gln Phe Leu Met Met His Arg Val 
                85                  90                  95      


Asn Thr Ser Lys Leu Glu Lys Gln Leu Leu Lys Leu Glu Gln Gln Ser 
            100                 105                 110         


Thr Gly Gly 
        115 


<210>  475
<211>  55
<212>  PRT
<213>  Homo sapiens

<400>  475

Met Leu Trp Phe Gln Gly Asn Ser Met Gln Leu Ala Arg Ser Ser Phe 
1               5                   10                  15      


Gly Leu Phe Leu Arg Asn Cys Ser Ala Ser Lys Thr Thr Leu Pro Val 
            20                  25                  30          


Leu Thr Leu Phe Thr Lys Glu Phe Leu Ser Thr Arg Ser Leu Phe Ala 
        35                  40                  45              


Cys Cys His Pro Cys Lys Met 
    50                  55  


<210>  476
<211>  59
<212>  PRT
<213>  Homo sapiens

<400>  476

Met Leu Trp Phe Gln Gly Asn Ser Met Gln Leu Ala Arg Ser Ser Phe 
1               5                   10                  15      


Gly Leu Phe Leu Arg Asn Cys Ser Ala Ser Lys Thr Thr Leu Pro Val 
            20                  25                  30          


Leu Thr Leu Phe Thr Lys Asp Pro Cys Pro Leu Cys Asp Glu Ala Lys 
        35                  40                  45              


Glu Val Leu Lys Pro Tyr Glu Asn Arg Val Ile 
    50                  55                  


<210>  477
<211>  138
<212>  PRT
<213>  Homo sapiens

<400>  477

Met Leu Trp Phe Gln Gly Asn Ser Met Gln Leu Ala Arg Ser Ser Phe 
1               5                   10                  15      


Gly Leu Phe Leu Arg Asn Cys Ser Ala Ser Lys Thr Thr Leu Pro Val 
            20                  25                  30          


Leu Thr Leu Phe Thr Lys Asp Pro Cys Pro Leu Cys Asp Glu Ala Lys 
        35                  40                  45              


Glu Val Leu Lys Pro Tyr Glu Asn Arg Gln Pro Tyr Lys Asp Gln Lys 
    50                  55                  60                  


Leu Pro Gly Thr Arg Arg Arg Arg Ser Pro Ser Ser Pro Ser His Pro 
65                  70                  75                  80  


His Met Ala Ser Gln Ser Gly Lys Arg Tyr Asn Leu Thr Leu Asn Gln 
                85                  90                  95      


Val Leu Ser Phe Asp Tyr Asp Met Gly Leu Asp Ala Pro Lys Thr Ile 
            100                 105                 110         


Ser Ser Asp Cys Gly Ala Phe Tyr Cys Leu Arg Met Phe Lys Ser Pro 
        115                 120                 125             


Asp Met Thr Cys Cys Phe Tyr Pro Lys Gln 
    130                 135             


<210>  478
<211>  57
<212>  PRT
<213>  Homo sapiens

<400>  478

Lys Thr Thr Leu Pro Val Leu Thr Leu Phe Thr Lys Asp Pro Cys Pro 
1               5                   10                  15      


Leu Cys Asp Glu Ala Lys Glu Val Leu Lys Pro Tyr Glu Asn Arg Phe 
            20                  25                  30          


Leu Met Met His Arg Val Asn Thr Ser Lys Leu Glu Lys Gln Leu Leu 
        35                  40                  45              


Lys Leu Glu Gln Gln Ser Thr Gly Gly 
    50                  55          


<210>  479
<211>  138
<212>  PRT
<213>  Homo sapiens

<400>  479

Met Leu Trp Phe Gln Gly Asn Ser Met Gln Leu Ala Arg Ser Ser Phe 
1               5                   10                  15      


Gly Leu Phe Leu Arg Asn Cys Ser Ala Ser Lys Thr Thr Leu Pro Val 
            20                  25                  30          


Leu Thr Leu Phe Thr Lys Asp Pro Cys Pro Leu Cys Asp Glu Ala Lys 
        35                  40                  45              


Glu Val Leu Lys Pro Tyr Glu Asn Arg Gln Pro Tyr Lys Asp Gln Lys 
    50                  55                  60                  


Leu Pro Gly Thr Arg Arg Arg Arg Ser Pro Ser Ser Pro Ser His Pro 
65                  70                  75                  80  


His Met Ala Ser Gln Ser Gly Lys Arg Tyr Asn Leu Thr Leu Asn Gln 
                85                  90                  95      


Val Leu Ser Phe Asp Tyr Asp Met Gly Leu Asp Ala Pro Lys Thr Ile 
            100                 105                 110         


Ser Ser Asp Cys Gly Ala Phe Tyr Cys Leu Arg Met Phe Lys Ser Pro 
        115                 120                 125             


Asp Met Thr Cys Cys Phe Tyr Pro Lys Gln 
    130                 135             


<210>  480
<211>  89
<212>  PRT
<213>  Homo sapiens

<400>  480

Met Leu Trp Phe Gln Gly Asn Ser Met Gln Leu Ala Arg Ser Ser Phe 
1               5                   10                  15      


Gly Leu Phe Leu Arg Asn Cys Ser Ala Ser Lys Thr Thr Leu Pro Val 
            20                  25                  30          


Leu Thr Leu Phe Thr Lys Asp Pro Cys Pro Leu Cys Asp Glu Ala Lys 
        35                  40                  45              


Glu Val Leu Lys Pro Tyr Glu Asn Arg Arg Ser Thr Ser Gln Ser Leu 
    50                  55                  60                  


Gly Asn Ala Ile Tyr Arg Lys Lys Val Leu His Ser Cys Cys Cys Pro 
65                  70                  75                  80  


Gly Gly Leu Asn Phe Leu Met Lys Glu 
                85                  


<210>  481
<211>  215
<212>  PRT
<213>  Homo sapiens

<400>  481

Met Lys Asp Tyr Asp Glu Leu Leu Lys Tyr Tyr Glu Leu His Glu Thr 
1               5                   10                  15      


Ile Gly Thr Gly Gly Phe Ala Lys Val Lys Leu Ala Cys His Ile Leu 
            20                  25                  30          


Thr Gly Glu Met Val Ala Ile Lys Ile Met Asp Lys Asn Thr Leu Gly 
        35                  40                  45              


Ser Asp Leu Pro Arg Ile Lys Thr Glu Ile Glu Ala Leu Lys Asn Leu 
    50                  55                  60                  


Arg His Gln His Ile Cys Gln Leu Tyr His Val Leu Glu Thr Ala Asn 
65                  70                  75                  80  


Lys Ile Phe Met Val Leu Glu Glu Asn Leu Leu Phe Asp Glu Tyr His 
                85                  90                  95      


Lys Leu Lys Leu Ile Asp Phe Gly Leu Cys Ala Lys Pro Lys Gly Asn 
            100                 105                 110         


Lys Asp Tyr His Leu Gln Thr Cys Cys Gly Ser Leu Ala Tyr Ala Ala 
        115                 120                 125             


Pro Glu Leu Ile Gln Gly Lys Ser Tyr Leu Gly Ser Glu Ala Asp Val 
    130                 135                 140                 


Trp Ser Met Gly Ile Leu Leu Tyr Val Leu Met Cys Gly Phe Leu Pro 
145                 150                 155                 160 


Phe Asp Asp Asp Asn Val Met Ala Leu Tyr Lys Lys Ile Met Arg Gly 
                165                 170                 175     


Lys Tyr Asp Val Pro Lys Trp Leu Ser Pro Ser Ser Ile Leu Leu Leu 
            180                 185                 190         


Gln Gln Met Leu Gln Val Asp Pro Lys Lys Arg Ile Ser Met Lys Asn 
        195                 200                 205             


Leu Leu Asn His Pro Trp Ile 
    210                 215 


<210>  482
<211>  580
<212>  PRT
<213>  Homo sapiens

<400>  482

Met Met Asn Phe Ser Asn Ile Met Asn Tyr Met Lys Leu Leu Gly Gln 
1               5                   10                  15      


Tyr Cys Pro Gly Gly Glu Leu Phe Asp Tyr Ile Ile Ser Gln Asp Arg 
            20                  25                  30          


Leu Ser Glu Glu Glu Thr Arg Val Val Phe Arg Gln Ile Val Ser Ala 
        35                  40                  45              


Val Ala Tyr Val His Ser Gln Gly Tyr Ala His Arg Asp Leu Lys Pro 
    50                  55                  60                  


Glu Asn Leu Leu Phe Asp Glu Tyr His Lys Leu Lys Leu Ile Asp Phe 
65                  70                  75                  80  


Gly Leu Cys Ala Lys Pro Lys Gly Asn Lys Asp Tyr His Leu Gln Thr 
                85                  90                  95      


Cys Cys Gly Ser Leu Ala Tyr Ala Ala Pro Glu Leu Ile Gln Gly Lys 
            100                 105                 110         


Ser Tyr Leu Gly Ser Glu Ala Asp Val Trp Ser Met Gly Ile Leu Leu 
        115                 120                 125             


Tyr Val Leu Met Cys Gly Phe Leu Pro Phe Asp Asp Asp Asn Val Met 
    130                 135                 140                 


Ala Leu Tyr Lys Lys Ile Met Arg Gly Lys Tyr Asp Val Pro Lys Trp 
145                 150                 155                 160 


Leu Ser Pro Ser Ser Ile Leu Leu Leu Gln Gln Met Leu Gln Val Asp 
                165                 170                 175     


Pro Lys Lys Arg Ile Ser Met Lys Asn Leu Leu Asn His Pro Trp Ile 
            180                 185                 190         


Met Gln Asp Tyr Asn Tyr Pro Val Glu Trp Gln Ser Lys Asn Pro Phe 
        195                 200                 205             


Ile His Leu Asp Asp Asp Cys Val Thr Glu Leu Ser Val His His Arg 
    210                 215                 220                 


Asn Asn Arg Gln Thr Met Glu Asp Leu Ile Ser Leu Trp Gln Tyr Asp 
225                 230                 235                 240 


His Leu Thr Ala Thr Tyr Leu Leu Leu Leu Ala Lys Lys Ala Arg Gly 
                245                 250                 255     


Lys Pro Val Arg Leu Arg Leu Ser Ser Phe Ser Cys Gly Gln Ala Ser 
            260                 265                 270         


Ala Thr Pro Phe Thr Asp Ile Lys Ser Asn Asn Trp Ser Leu Glu Asp 
        275                 280                 285             


Val Thr Ala Ser Asp Lys Asn Tyr Val Ala Gly Leu Ile Asp Tyr Asp 
    290                 295                 300                 


Trp Cys Glu Asp Asp Leu Ser Thr Gly Ala Ala Thr Pro Arg Thr Ser 
305                 310                 315                 320 


Gln Phe Thr Lys Tyr Trp Thr Glu Ser Asn Gly Val Glu Ser Lys Ser 
                325                 330                 335     


Leu Thr Pro Ala Leu Cys Arg Thr Pro Ala Asn Lys Leu Lys Asn Lys 
            340                 345                 350         


Glu Asn Val Tyr Thr Pro Lys Ser Ala Val Lys Asn Glu Glu Tyr Phe 
        355                 360                 365             


Met Phe Pro Glu Pro Lys Thr Pro Val Asn Lys Asn Gln His Lys Arg 
    370                 375                 380                 


Glu Ile Leu Thr Thr Pro Asn Arg Tyr Thr Thr Pro Ser Lys Ala Arg 
385                 390                 395                 400 


Asn Gln Cys Leu Lys Glu Thr Pro Ile Lys Ile Pro Val Asn Ser Thr 
                405                 410                 415     


Gly Thr Asp Lys Leu Met Thr Gly Val Ile Ser Pro Glu Arg Arg Cys 
            420                 425                 430         


Arg Ser Val Glu Leu Asp Leu Asn Gln Ala His Met Glu Glu Thr Pro 
        435                 440                 445             


Lys Arg Lys Gly Ala Lys Val Phe Gly Ser Leu Glu Arg Gly Leu Asp 
    450                 455                 460                 


Lys Val Ile Thr Val Leu Thr Arg Ser Lys Arg Lys Gly Ser Ala Arg 
465                 470                 475                 480 


Asp Gly Pro Arg Arg Leu Lys Leu His Tyr Asn Val Thr Thr Thr Arg 
                485                 490                 495     


Leu Val Asn Pro Asp Gln Leu Leu Asn Glu Ile Met Ser Ile Leu Pro 
            500                 505                 510         


Lys Lys His Val Asp Phe Val Gln Lys Gly Tyr Thr Leu Lys Cys Gln 
        515                 520                 525             


Thr Gln Ser Asp Phe Gly Lys Val Thr Met Gln Phe Glu Leu Glu Val 
    530                 535                 540                 


Cys Gln Leu Gln Lys Pro Asp Val Val Gly Ile Arg Arg Gln Arg Leu 
545                 550                 555                 560 


Lys Gly Asp Ala Trp Val Tyr Lys Arg Leu Val Glu Asp Ile Leu Ser 
                565                 570                 575     


Ser Cys Lys Val 
            580 


<210>  483
<211>  520
<212>  PRT
<213>  Homo sapiens

<400>  483

Met Val Leu Glu Glu Asn Leu Leu Phe Asp Glu Tyr His Lys Leu Lys 
1               5                   10                  15      


Leu Ile Asp Phe Gly Leu Cys Ala Lys Pro Lys Gly Asn Lys Asp Tyr 
            20                  25                  30          


His Leu Gln Thr Cys Cys Gly Ser Leu Ala Tyr Ala Ala Pro Glu Leu 
        35                  40                  45              


Ile Gln Gly Lys Ser Tyr Leu Gly Ser Glu Ala Asp Val Trp Ser Met 
    50                  55                  60                  


Gly Ile Leu Leu Tyr Val Leu Met Cys Gly Phe Leu Pro Phe Asp Asp 
65                  70                  75                  80  


Asp Asn Val Met Ala Leu Tyr Lys Lys Ile Met Arg Gly Lys Tyr Asp 
                85                  90                  95      


Val Pro Lys Trp Leu Ser Pro Ser Ser Ile Leu Leu Leu Gln Gln Met 
            100                 105                 110         


Leu Gln Val Asp Pro Lys Lys Arg Ile Ser Met Lys Asn Leu Leu Asn 
        115                 120                 125             


His Pro Trp Ile Met Gln Asp Tyr Asn Tyr Pro Val Glu Trp Gln Ser 
    130                 135                 140                 


Lys Asn Pro Phe Ile His Leu Asp Asp Asp Cys Val Thr Glu Leu Ser 
145                 150                 155                 160 


Val His His Arg Asn Asn Arg Gln Thr Met Glu Asp Leu Ile Ser Leu 
                165                 170                 175     


Trp Gln Tyr Asp His Leu Thr Ala Thr Tyr Leu Leu Leu Leu Ala Lys 
            180                 185                 190         


Lys Ala Arg Gly Lys Pro Val Arg Leu Arg Leu Ser Ser Phe Ser Cys 
        195                 200                 205             


Gly Gln Ala Ser Ala Thr Pro Phe Thr Asp Ile Lys Ser Asn Asn Trp 
    210                 215                 220                 


Ser Leu Glu Asp Val Thr Ala Ser Asp Lys Asn Tyr Val Ala Gly Leu 
225                 230                 235                 240 


Ile Asp Tyr Asp Trp Cys Glu Asp Asp Leu Ser Thr Gly Ala Ala Thr 
                245                 250                 255     


Pro Arg Thr Ser Gln Phe Thr Lys Tyr Trp Thr Glu Ser Asn Gly Val 
            260                 265                 270         


Glu Ser Lys Ser Leu Thr Pro Ala Leu Cys Arg Thr Pro Ala Asn Lys 
        275                 280                 285             


Leu Lys Asn Lys Glu Asn Val Tyr Thr Pro Lys Ser Ala Val Lys Asn 
    290                 295                 300                 


Glu Glu Tyr Phe Met Phe Pro Glu Pro Lys Thr Pro Val Asn Lys Asn 
305                 310                 315                 320 


Gln His Lys Arg Glu Ile Leu Thr Thr Pro Asn Arg Tyr Thr Thr Pro 
                325                 330                 335     


Ser Lys Ala Arg Asn Gln Cys Leu Lys Glu Thr Pro Ile Lys Ile Pro 
            340                 345                 350         


Val Asn Ser Thr Gly Thr Asp Lys Leu Met Thr Gly Val Ile Ser Pro 
        355                 360                 365             


Glu Arg Arg Cys Arg Ser Val Glu Leu Asp Leu Asn Gln Ala His Met 
    370                 375                 380                 


Glu Glu Thr Pro Lys Arg Lys Gly Ala Lys Val Phe Gly Ser Leu Glu 
385                 390                 395                 400 


Arg Gly Leu Asp Lys Val Ile Thr Val Leu Thr Arg Ser Lys Arg Lys 
                405                 410                 415     


Gly Ser Ala Arg Asp Gly Pro Arg Arg Leu Lys Leu His Tyr Asn Val 
            420                 425                 430         


Thr Thr Thr Arg Leu Val Asn Pro Asp Gln Leu Leu Asn Glu Ile Met 
        435                 440                 445             


Ser Ile Leu Pro Lys Lys His Val Asp Phe Val Gln Lys Gly Tyr Thr 
    450                 455                 460                 


Leu Lys Cys Gln Thr Gln Ser Asp Phe Gly Lys Val Thr Met Gln Phe 
465                 470                 475                 480 


Glu Leu Glu Val Cys Gln Leu Gln Lys Pro Asp Val Val Gly Ile Arg 
                485                 490                 495     


Arg Gln Arg Leu Lys Gly Asp Ala Trp Val Tyr Lys Arg Leu Val Glu 
            500                 505                 510         


Asp Ile Leu Ser Ser Cys Lys Val 
        515                 520 


<210>  484
<211>  619
<212>  PRT
<213>  Homo sapiens

<400>  484

Met Met Asn Phe Ser Asn Ile Met Asn Tyr Met Lys Leu Leu Gly Gln 
1               5                   10                  15      


Ser Asp Leu Pro Arg Ile Lys Thr Glu Ile Glu Ala Leu Lys Asn Leu 
            20                  25                  30          


Arg His Gln His Ile Cys Gln Leu Tyr His Val Leu Glu Thr Ala Asn 
        35                  40                  45              


Lys Ile Phe Met Val Leu Glu Tyr Cys Pro Gly Gly Glu Leu Phe Asp 
    50                  55                  60                  


Tyr Ile Ile Ser Gln Asp Arg Leu Ser Glu Glu Glu Thr Arg Val Val 
65                  70                  75                  80  


Phe Arg Gln Ile Val Ser Ala Val Ala Tyr Val His Ser Gln Gly Tyr 
                85                  90                  95      


Ala His Arg Asp Leu Lys Pro Glu Asn Leu Leu Phe Asp Glu Tyr His 
            100                 105                 110         


Lys Leu Lys Leu Ile Asp Phe Gly Leu Cys Ala Lys Pro Lys Gly Asn 
        115                 120                 125             


Lys Asp Tyr His Leu Gln Thr Cys Cys Gly Ser Leu Ala Tyr Ala Ala 
    130                 135                 140                 


Pro Glu Leu Ile Gln Gly Lys Ser Tyr Leu Gly Ser Glu Ala Asp Val 
145                 150                 155                 160 


Trp Ser Met Gly Ile Leu Leu Tyr Val Leu Met Cys Gly Phe Leu Pro 
                165                 170                 175     


Phe Asp Asp Asp Asn Val Met Ala Leu Tyr Lys Lys Ile Met Arg Gly 
            180                 185                 190         


Lys Tyr Asp Val Pro Lys Trp Leu Ser Pro Ser Ser Ile Leu Leu Leu 
        195                 200                 205             


Gln Gln Met Leu Gln Val Asp Pro Lys Lys Arg Ile Ser Met Lys Asn 
    210                 215                 220                 


Leu Leu Asn His Pro Trp Ile Met Gln Asp Tyr Asn Tyr Pro Val Glu 
225                 230                 235                 240 


Trp Gln Ser Lys Asn Pro Phe Ile His Leu Asp Asp Asp Cys Val Thr 
                245                 250                 255     


Glu Leu Ser Val His His Arg Asn Asn Arg Gln Thr Met Glu Asp Leu 
            260                 265                 270         


Ile Ser Leu Trp Gln Tyr Asp His Leu Thr Ala Thr Tyr Leu Leu Leu 
        275                 280                 285             


Leu Ala Lys Lys Ala Arg Gly Lys Pro Val Arg Leu Arg Leu Ser Ser 
    290                 295                 300                 


Phe Ser Cys Gly Gln Ala Ser Ala Thr Pro Phe Thr Asp Ile Lys Ser 
305                 310                 315                 320 


Asn Asn Trp Ser Leu Glu Asp Val Thr Ala Ser Asp Lys Asn Tyr Val 
                325                 330                 335     


Ala Gly Leu Ile Asp Tyr Asp Trp Cys Glu Asp Asp Leu Ser Thr Gly 
            340                 345                 350         


Ala Ala Thr Pro Arg Thr Ser Gln Phe Thr Lys Tyr Trp Thr Glu Ser 
        355                 360                 365             


Asn Gly Val Glu Ser Lys Ser Leu Thr Pro Ala Leu Cys Arg Thr Pro 
    370                 375                 380                 


Ala Asn Lys Leu Lys Asn Lys Glu Asn Val Tyr Thr Pro Lys Ser Ala 
385                 390                 395                 400 


Val Lys Asn Glu Glu Tyr Phe Met Phe Pro Glu Pro Lys Thr Pro Val 
                405                 410                 415     


Asn Lys Asn Gln His Lys Arg Glu Ile Leu Thr Thr Pro Asn Arg Tyr 
            420                 425                 430         


Thr Thr Pro Ser Lys Ala Arg Asn Gln Cys Leu Lys Glu Thr Pro Ile 
        435                 440                 445             


Lys Ile Pro Val Asn Ser Thr Gly Thr Asp Lys Leu Met Thr Gly Val 
    450                 455                 460                 


Ile Ser Pro Glu Arg Arg Cys Arg Ser Val Glu Leu Asp Leu Asn Gln 
465                 470                 475                 480 


Ala His Met Glu Glu Thr Pro Lys Arg Lys Gly Ala Lys Val Phe Gly 
                485                 490                 495     


Ser Leu Glu Arg Gly Leu Asp Lys Val Ile Thr Val Leu Thr Arg Ser 
            500                 505                 510         


Lys Arg Lys Gly Ser Ala Arg Asp Gly Pro Arg Arg Leu Lys Leu His 
        515                 520                 525             


Tyr Asn Val Thr Thr Thr Arg Leu Val Asn Pro Asp Gln Leu Leu Asn 
    530                 535                 540                 


Glu Ile Met Ser Ile Leu Pro Lys Lys His Val Asp Phe Val Gln Lys 
545                 550                 555                 560 


Gly Tyr Thr Leu Lys Cys Gln Thr Gln Ser Asp Phe Gly Lys Val Thr 
                565                 570                 575     


Met Gln Phe Glu Leu Glu Val Cys Gln Leu Gln Lys Pro Asp Val Val 
            580                 585                 590         


Gly Ile Arg Arg Gln Arg Leu Lys Gly Asp Ala Trp Val Tyr Lys Arg 
        595                 600                 605             


Leu Val Glu Asp Ile Leu Ser Ser Cys Lys Val 
    610                 615                 


<210>  485
<211>  129
<212>  PRT
<213>  Homo sapiens

<400>  485

Met Val Leu Glu Tyr Cys Pro Gly Gly Glu Leu Phe Asp Tyr Ile Ile 
1               5                   10                  15      


Ser Gln Asp Arg Leu Ser Glu Glu Glu Thr Arg Val Val Phe Arg Gln 
            20                  25                  30          


Ile Val Ser Ala Val Ala Tyr Val His Ser Gln Gly Tyr Ala His Arg 
        35                  40                  45              


Asp Leu Lys Pro Glu Asn Leu Leu Phe Asp Glu Tyr His Lys Leu Lys 
    50                  55                  60                  


Leu Ile Asp Phe Gly Leu Cys Ala Lys Pro Lys Gly Asn Lys Asp Tyr 
65                  70                  75                  80  


His Leu Gln Thr Cys Cys Gly Ser Leu Ala Tyr Ala Ala Pro Glu Leu 
                85                  90                  95      


Ile Gln Gly Lys Ser Tyr Leu Gly Ser Glu Met Phe Gly Ala Trp Ala 
            100                 105                 110         


Tyr Cys Tyr Met Phe Leu Cys Val Asp Phe Tyr His Leu Met Met Ile 
        115                 120                 125             


Met 
    


<210>  486
<211>  532
<212>  PRT
<213>  Homo sapiens

<400>  486

Met Ala Pro Ser Phe Thr Ala Arg Ile Gln Leu Phe Leu Leu Arg Ala 
1               5                   10                  15      


Leu Gly Phe Leu Ile Gly Leu Val Gly Arg Ala Ala Leu Val Leu Gly 
            20                  25                  30          


Gly Pro Lys Phe Ala Ser Lys Thr Pro Arg Pro Val Thr Glu Pro Leu 
        35                  40                  45              


Leu Leu Leu Ser Gly Met Gln Leu Ala Lys Leu Ile Arg Gln Arg Lys 
    50                  55                  60                  


Val Lys Cys Ile Asp Val Val Gln Ala Tyr Ile Asn Arg Ile Lys Asp 
65                  70                  75                  80  


Val Asn Pro Met Ile Asn Gly Ile Val Lys Tyr Arg Phe Glu Glu Ala 
                85                  90                  95      


Met Lys Glu Ala His Ala Val Asp Gln Lys Leu Ala Glu Lys Gln Glu 
            100                 105                 110         


Asp Glu Ala Thr Leu Glu Asn Lys Trp Pro Phe Leu Gly Val Pro Leu 
        115                 120                 125             


Thr Val Lys Glu Ala Phe Gln Leu Gln Gly Met Pro Asn Ser Ser Gly 
    130                 135                 140                 


Leu Met Asn Arg Arg Asp Ala Ile Ala Lys Thr Asp Ala Thr Val Val 
145                 150                 155                 160 


Ala Leu Leu Lys Gly Ala Gly Ala Ile Pro Leu Gly Ile Thr Asn Cys 
                165                 170                 175     


Ser Glu Leu Cys Met Trp Tyr Glu Ser Ser Asn Lys Ile Tyr Gly Arg 
            180                 185                 190         


Ser Asn Asn Pro Tyr Asp Leu Gln His Ile Val Gly Gly Ser Ser Gly 
        195                 200                 205             


Gly Glu Gly Cys Thr Leu Ala Ala Ala Cys Ser Val Ile Gly Val Gly 
    210                 215                 220                 


Ser Asp Ile Gly Gly Ser Ile Arg Met Pro Ala Phe Phe Asn Gly Ile 
225                 230                 235                 240 


Phe Gly His Lys Pro Ser Pro Gly Val Val Pro Asn Lys Gly Gln Phe 
                245                 250                 255     


Pro Leu Ala Val Gly Ala Gln Glu Leu Phe Leu Cys Thr Gly Pro Met 
            260                 265                 270         


Cys Arg Tyr Ala Glu Asp Leu Ala Pro Met Leu Lys Val Met Ala Gly 
        275                 280                 285             


Pro Gly Ile Lys Arg Leu Lys Leu Asp Thr Lys Val His Leu Lys Asp 
    290                 295                 300                 


Leu Lys Phe Tyr Trp Met Glu His Asp Gly Gly Ser Phe Leu Met Ser 
305                 310                 315                 320 


Lys Val Asp Gln Asp Leu Ile Met Thr Gln Lys Lys Val Val Val His 
                325                 330                 335     


Leu Glu Thr Ile Leu Gly Ala Ser Val Gln His Val Lys Leu Lys Lys 
            340                 345                 350         


Met Lys Tyr Ser Phe Gln Leu Trp Ile Ala Met Met Ser Ala Lys Gly 
        355                 360                 365             


His Asp Gly Lys Glu Pro Val Lys Phe Val Asp Leu Leu Gly Asp His 
    370                 375                 380                 


Gly Lys His Val Ser Pro Leu Trp Glu Leu Ile Lys Trp Cys Leu Gly 
385                 390                 395                 400 


Leu Ser Val Tyr Thr Ile Pro Ser Ile Gly Leu Ala Leu Leu Glu Glu 
                405                 410                 415     


Lys Leu Arg Tyr Ser Asn Glu Lys Tyr Gln Lys Phe Lys Ala Val Glu 
            420                 425                 430         


Glu Ser Leu Arg Lys Glu Leu Val Asp Met Leu Gly Asp Asp Gly Val 
        435                 440                 445             


Phe Leu Tyr Pro Ser His Pro Thr Val Ala Pro Lys His His Val Pro 
    450                 455                 460                 


Leu Thr Arg Pro Phe Asn Phe Ala Tyr Thr Gly Val Phe Ser Ala Leu 
465                 470                 475                 480 


Gly Leu Pro Val Thr Gln Cys Pro Leu Gly Leu Asn Ala Lys Gly Leu 
                485                 490                 495     


Pro Leu Gly Ile Gln Val Val Ala Gly Pro Phe Asn Asp His Leu Thr 
            500                 505                 510         


Leu Ala Val Ala Gln Tyr Leu Glu Lys Thr Phe Gly Gly Trp Val Cys 
        515                 520                 525             


Pro Gly Lys Phe 
    530         


<210>  487
<211>  563
<212>  PRT
<213>  Homo sapiens

<400>  487

Met Gly Leu Gln Ala Cys Leu Leu Gly Leu Phe Ala Leu Ile Leu Ser 
1               5                   10                  15      


Gly Lys Cys Ser Tyr Ser Pro Glu Pro Asp Gln Arg Arg Thr Leu Pro 
            20                  25                  30          


Pro Gly Trp Val Ser Leu Gly Arg Ala Asp Pro Glu Glu Glu Leu Ser 
        35                  40                  45              


Leu Thr Phe Ala Leu Arg Gln Gln Asn Val Glu Arg Leu Ser Glu Leu 
    50                  55                  60                  


Val Gln Ala Val Ser Asp Pro Ser Ser Pro Gln Tyr Gly Lys Tyr Leu 
65                  70                  75                  80  


Thr Leu Glu Asn Val Ala Asp Leu Val Arg Pro Ser Pro Leu Thr Leu 
                85                  90                  95      


His Thr Val Gln Lys Trp Leu Leu Ala Ala Gly Ala Gln Lys Cys His 
            100                 105                 110         


Ser Val Ile Thr Gln Asp Phe Leu Thr Cys Trp Leu Ser Ile Arg Gln 
        115                 120                 125             


Ala Glu Leu Leu Leu Pro Gly Ala Glu Phe His His Tyr Val Gly Gly 
    130                 135                 140                 


Pro Thr Glu Thr His Val Val Arg Ser Pro His Pro Tyr Gln Leu Pro 
145                 150                 155                 160 


Gln Ala Leu Ala Pro His Val Asp Phe Val Gly Gly Leu His Arg Phe 
                165                 170                 175     


Pro Pro Thr Ser Ser Leu Arg Gln Arg Pro Glu Pro Gln Val Thr Gly 
            180                 185                 190         


Thr Val Gly Leu His Leu Gly Val Thr Pro Ser Val Ile Arg Lys Arg 
        195                 200                 205             


Tyr Asn Leu Thr Ser Gln Asp Val Gly Ser Gly Thr Ser Asn Asn Ser 
    210                 215                 220                 


Gln Ala Cys Ala Gln Phe Leu Glu Gln Tyr Phe His Asp Ser Asp Leu 
225                 230                 235                 240 


Ala Gln Phe Met Arg Leu Phe Gly Gly Asn Phe Ala His Gln Ala Ser 
                245                 250                 255     


Val Ala Arg Val Val Gly Gln Gln Gly Arg Gly Arg Ala Gly Ile Glu 
            260                 265                 270         


Ala Ser Leu Asp Val Gln Tyr Leu Met Ser Ala Gly Ala Asn Ile Ser 
        275                 280                 285             


Thr Trp Val Tyr Ser Ser Pro Gly Arg His Glu Gly Gln Glu Pro Phe 
    290                 295                 300                 


Leu Gln Trp Leu Met Leu Leu Ser Asn Glu Ser Ala Leu Pro His Val 
305                 310                 315                 320 


His Thr Val Ser Tyr Gly Asp Asp Glu Asp Ser Leu Ser Ser Ala Tyr 
                325                 330                 335     


Ile Gln Arg Val Asn Thr Glu Leu Met Lys Ala Ala Ala Arg Gly Leu 
            340                 345                 350         


Thr Leu Leu Phe Ala Ser Gly Asp Ser Gly Ala Gly Cys Trp Ser Val 
        355                 360                 365             


Ser Gly Arg His Gln Phe Arg Pro Thr Phe Pro Ala Ser Ser Pro Tyr 
    370                 375                 380                 


Val Thr Thr Val Gly Gly Thr Ser Phe Gln Glu Pro Phe Leu Ile Thr 
385                 390                 395                 400 


Asn Glu Ile Val Asp Tyr Ile Ser Gly Gly Gly Phe Ser Asn Val Phe 
                405                 410                 415     


Pro Arg Pro Ser Tyr Gln Glu Glu Ala Val Thr Lys Phe Leu Ser Ser 
            420                 425                 430         


Ser Pro His Leu Pro Pro Ser Ser Tyr Phe Asn Ala Ser Gly Arg Ala 
        435                 440                 445             


Tyr Pro Asp Val Ala Ala Leu Ser Asp Gly Tyr Trp Val Val Ser Asn 
    450                 455                 460                 


Arg Val Pro Ile Pro Trp Val Ser Gly Thr Ser Ala Ser Thr Pro Val 
465                 470                 475                 480 


Phe Gly Gly Ile Leu Ser Leu Ile Asn Glu His Arg Ile Leu Ser Gly 
                485                 490                 495     


Arg Pro Pro Leu Gly Phe Leu Asn Pro Arg Leu Tyr Gln Gln His Gly 
            500                 505                 510         


Ala Gly Leu Phe Asp Val Thr Arg Gly Cys His Glu Ser Cys Leu Asp 
        515                 520                 525             


Glu Glu Val Glu Gly Gln Gly Phe Cys Ser Gly Pro Gly Trp Asp Pro 
    530                 535                 540                 


Val Thr Gly Trp Gly Thr Pro Asn Phe Pro Ala Leu Leu Lys Thr Leu 
545                 550                 555                 560 


Leu Asn Pro 
            


<210>  488
<211>  177
<212>  PRT
<213>  Homo sapiens

<400>  488

Met Gly Leu Gln Ala Cys Leu Leu Gly Leu Phe Ala Leu Ile Leu Ser 
1               5                   10                  15      


Gly Lys Cys Ser Tyr Ser Pro Glu Pro Asp Gln Arg Arg Thr Leu Pro 
            20                  25                  30          


Pro Gly Trp Val Ser Leu Gly Arg Ala Asp Pro Glu Glu Glu Leu Ser 
        35                  40                  45              


Leu Thr Phe Ala Leu Arg Gln Gln Asn Val Glu Arg Leu Ser Glu Leu 
    50                  55                  60                  


Val Gln Ala Val Ser Asp Pro Ser Ser Pro Gln Tyr Gly Lys Tyr Leu 
65                  70                  75                  80  


Thr Leu Glu Asn Val Ala Asp Leu Val Arg Pro Ser Pro Leu Thr Leu 
                85                  90                  95      


His Thr Val Gln Lys Trp Leu Leu Ala Ala Gly Ala Gln Lys Cys His 
            100                 105                 110         


Ser Val Ile Thr Gln Asp Phe Leu Thr Cys Trp Leu Ser Ile Arg Gln 
        115                 120                 125             


Ala Glu Leu Leu Leu Pro Gly Ala Glu Phe His His Tyr Val Gly Gly 
    130                 135                 140                 


Pro Thr Glu Thr His Val Ala Gly Met Arg Asp Arg Ser Pro Ser Cys 
145                 150                 155                 160 


Ser Gly Ser Cys Cys Ser Val Met Ser Gln Pro Cys His Met Cys Ile 
                165                 170                 175     


Leu 
    


<210>  489
<211>  39
<212>  PRT
<213>  Homo sapiens

<400>  489

Met Gly Leu Gln Ala Cys Leu Leu Gly Leu Phe Ala Leu Ile Leu Ser 
1               5                   10                  15      


Gly Lys Cys Ser Tyr Ser Pro Glu Pro Asp Gln Arg Arg Thr Lys Ile 
            20                  25                  30          


Pro Asp Pro Arg Glu Cys Gly 
        35                  


<210>  490
<211>  30
<212>  PRT
<213>  Homo sapiens

<400>  490

Met Gly Leu Gln Ala Cys Leu Leu Gly Leu Phe Ala Leu Ile Leu Ser 
1               5                   10                  15      


Gly Lys Cys Ser Tyr Ser Pro Glu Pro Asp Gln Arg Arg Thr 
            20                  25                  30  


<210>  491
<211>  387
<212>  PRT
<213>  Homo sapiens

<400>  491

Met Arg Glu Pro Leu Glu Ala Phe Lys Leu Ala Asp Leu Asp Phe Arg 
1               5                   10                  15      


Lys Ser Ser Leu Ala Ser Gly Trp Arg Met Ala Ser Gly Ala Phe Thr 
            20                  25                  30          


Met Asp Gln Phe Pro Glu Ser Val Thr Glu Asn Phe Glu Tyr Asp Asp 
        35                  40                  45              


Leu Ala Glu Ala Cys Tyr Ile Gly Asp Ile Val Val Phe Gly Thr Val 
    50                  55                  60                  


Phe Leu Ser Ile Phe Tyr Ser Val Ile Phe Ala Ile Gly Leu Val Gly 
65                  70                  75                  80  


Asn Leu Leu Val Val Phe Ala Leu Thr Asn Ser Lys Lys Pro Lys Ser 
                85                  90                  95      


Val Thr Asp Ile Tyr Leu Leu Asn Leu Ala Leu Ser Asp Leu Leu Phe 
            100                 105                 110         


Val Ala Thr Leu Pro Phe Trp Thr His Tyr Leu Ile Asn Glu Lys Gly 
        115                 120                 125             


Leu His Asn Ala Met Cys Lys Phe Thr Thr Ala Phe Phe Phe Ile Gly 
    130                 135                 140                 


Phe Phe Gly Ser Ile Phe Phe Ile Thr Val Ile Ser Ile Asp Arg Tyr 
145                 150                 155                 160 


Leu Ala Ile Val Leu Ala Ala Asn Ser Met Asn Asn Arg Thr Val Gln 
                165                 170                 175     


His Gly Val Thr Ile Ser Leu Gly Val Trp Ala Ala Ala Ile Leu Val 
            180                 185                 190         


Ala Ala Pro Gln Phe Met Phe Thr Lys Gln Lys Glu Asn Glu Cys Leu 
        195                 200                 205             


Gly Asp Tyr Pro Glu Val Leu Gln Glu Ile Trp Pro Val Leu Arg Asn 
    210                 215                 220                 


Val Glu Thr Asn Phe Leu Gly Phe Leu Leu Pro Leu Leu Ile Met Ser 
225                 230                 235                 240 


Tyr Cys Tyr Phe Arg Ile Ile Gln Thr Leu Phe Ser Cys Lys Asn His 
                245                 250                 255     


Lys Lys Ala Lys Ala Ile Lys Leu Ile Leu Leu Val Val Ile Val Phe 
            260                 265                 270         


Phe Leu Phe Trp Thr Pro Tyr Asn Val Met Ile Phe Leu Glu Thr Leu 
        275                 280                 285             


Lys Leu Tyr Asp Phe Phe Pro Ser Cys Asp Met Arg Lys Asp Leu Arg 
    290                 295                 300                 


Leu Ala Leu Ser Val Thr Glu Thr Val Ala Phe Ser His Cys Cys Leu 
305                 310                 315                 320 


Asn Pro Leu Ile Tyr Ala Phe Ala Gly Glu Lys Phe Arg Arg Tyr Leu 
                325                 330                 335     


Tyr His Leu Tyr Gly Lys Cys Leu Ala Val Leu Cys Gly Arg Ser Val 
            340                 345                 350         


His Val Asp Phe Ser Ser Ser Glu Ser Gln Arg Ser Arg His Gly Ser 
        355                 360                 365             


Val Leu Ser Ser Asn Phe Thr Tyr His Thr Ser Asp Gly Asp Ala Leu 
    370                 375                 380                 


Leu Leu Leu 
385         


<210>  492
<211>  355
<212>  PRT
<213>  Homo sapiens

<400>  492

Met Asp Gln Phe Pro Glu Ser Val Thr Glu Asn Phe Glu Tyr Asp Asp 
1               5                   10                  15      


Leu Ala Glu Ala Cys Tyr Ile Gly Asp Ile Val Val Phe Gly Thr Val 
            20                  25                  30          


Phe Leu Ser Ile Phe Tyr Ser Val Ile Phe Ala Ile Gly Leu Val Gly 
        35                  40                  45              


Asn Leu Leu Val Val Phe Ala Leu Thr Asn Ser Lys Lys Pro Lys Ser 
    50                  55                  60                  


Val Thr Asp Ile Tyr Leu Leu Asn Leu Ala Leu Ser Asp Leu Leu Phe 
65                  70                  75                  80  


Val Ala Thr Leu Pro Phe Trp Thr His Tyr Leu Ile Asn Glu Lys Gly 
                85                  90                  95      


Leu His Asn Ala Met Cys Lys Phe Thr Thr Ala Phe Phe Phe Ile Gly 
            100                 105                 110         


Phe Phe Gly Ser Ile Phe Phe Ile Thr Val Ile Ser Ile Asp Arg Tyr 
        115                 120                 125             


Leu Ala Ile Val Leu Ala Ala Asn Ser Met Asn Asn Arg Thr Val Gln 
    130                 135                 140                 


His Gly Val Thr Ile Ser Leu Gly Val Trp Ala Ala Ala Ile Leu Val 
145                 150                 155                 160 


Ala Ala Pro Gln Phe Met Phe Thr Lys Gln Lys Glu Asn Glu Cys Leu 
                165                 170                 175     


Gly Asp Tyr Pro Glu Val Leu Gln Glu Ile Trp Pro Val Leu Arg Asn 
            180                 185                 190         


Val Glu Thr Asn Phe Leu Gly Phe Leu Leu Pro Leu Leu Ile Met Ser 
        195                 200                 205             


Tyr Cys Tyr Phe Arg Ile Ile Gln Thr Leu Phe Ser Cys Lys Asn His 
    210                 215                 220                 


Lys Lys Ala Lys Ala Ile Lys Leu Ile Leu Leu Val Val Ile Val Phe 
225                 230                 235                 240 


Phe Leu Phe Trp Thr Pro Tyr Asn Val Met Ile Phe Leu Glu Thr Leu 
                245                 250                 255     


Lys Leu Tyr Asp Phe Phe Pro Ser Cys Asp Met Arg Lys Asp Leu Arg 
            260                 265                 270         


Leu Ala Leu Ser Val Thr Glu Thr Val Ala Phe Ser His Cys Cys Leu 
        275                 280                 285             


Asn Pro Leu Ile Tyr Ala Phe Ala Gly Glu Lys Phe Arg Arg Tyr Leu 
    290                 295                 300                 


Tyr His Leu Tyr Gly Lys Cys Leu Ala Val Leu Cys Gly Arg Ser Val 
305                 310                 315                 320 


His Val Asp Phe Ser Ser Ser Glu Ser Gln Arg Ser Arg His Gly Ser 
                325                 330                 335     


Val Leu Ser Ser Asn Phe Thr Tyr His Thr Ser Asp Gly Asp Ala Leu 
            340                 345                 350         


Leu Leu Leu 
        355 


<210>  493
<211>  106
<212>  PRT
<213>  Homo sapiens

<400>  493

Met Asp Gln Phe Pro Glu Ser Val Thr Glu Asn Phe Glu Tyr Asp Asp 
1               5                   10                  15      


Leu Ala Glu Ala Cys Tyr Ile Gly Asp Ile Val Val Phe Gly Thr Val 
            20                  25                  30          


Phe Leu Ser Ile Phe Tyr Ser Val Ile Phe Ala Ile Gly Leu Val Gly 
        35                  40                  45              


Asn Leu Leu Val Val Phe Ala Leu Thr Asn Ser Lys Lys Pro Lys Ser 
    50                  55                  60                  


Val Thr Asp Ile Tyr Leu Leu Asn Leu Ala Leu Ser Asp Leu Leu Phe 
65                  70                  75                  80  


Val Ala Thr Leu Pro Phe Trp Thr His Tyr Leu Ile Asn Glu Lys Gly 
                85                  90                  95      


Leu His Asn Ala Met Cys Lys Phe Thr Thr 
            100                 105     


<210>  494
<211>  166
<212>  PRT
<213>  Homo sapiens

<400>  494

Met Asp Gln Phe Pro Glu Ser Val Thr Glu Asn Phe Glu Tyr Asp Asp 
1               5                   10                  15      


Leu Ala Glu Ala Cys Tyr Ile Gly Asp Ile Val Val Phe Gly Thr Val 
            20                  25                  30          


Phe Leu Ser Ile Phe Tyr Ser Val Ile Phe Ala Ile Gly Leu Val Gly 
        35                  40                  45              


Asn Leu Leu Val Val Phe Ala Leu Thr Asn Ser Lys Lys Pro Lys Ser 
    50                  55                  60                  


Val Thr Asp Ile Tyr Leu Leu Asn Leu Ala Leu Ser Asp Leu Leu Phe 
65                  70                  75                  80  


Val Ala Thr Leu Pro Phe Trp Thr His Tyr Leu Ile Asn Glu Lys Gly 
                85                  90                  95      


Leu His Asn Ala Met Cys Lys Phe Thr Thr Ala Phe Phe Phe Ile Gly 
            100                 105                 110         


Phe Phe Gly Ser Ile Phe Phe Ile Thr Val Ile Ser Ile Asp Arg Tyr 
        115                 120                 125             


Leu Ala Ile Val Leu Ala Ala Asn Ser Met Asn Asn Arg Thr Val Gln 
    130                 135                 140                 


His Gly Val Thr Ile Ser Leu Gly Val Trp Ala Ala Ala Ile Leu Val 
145                 150                 155                 160 


Ala Ala Pro Gln Phe Met 
                165     


<210>  495
<211>  355
<212>  PRT
<213>  Homo sapiens

<400>  495

Met Asp Gln Phe Pro Glu Ser Val Thr Glu Asn Phe Glu Tyr Asp Asp 
1               5                   10                  15      


Leu Ala Glu Ala Cys Tyr Ile Gly Asp Ile Val Val Phe Gly Thr Val 
            20                  25                  30          


Phe Leu Ser Ile Phe Tyr Ser Val Ile Phe Ala Ile Gly Leu Val Gly 
        35                  40                  45              


Asn Leu Leu Val Val Phe Ala Leu Thr Asn Ser Lys Lys Pro Lys Ser 
    50                  55                  60                  


Val Thr Asp Ile Tyr Leu Leu Asn Leu Ala Leu Ser Asp Leu Leu Phe 
65                  70                  75                  80  


Val Ala Thr Leu Pro Phe Trp Thr His Tyr Leu Ile Asn Glu Lys Gly 
                85                  90                  95      


Leu His Asn Ala Met Cys Lys Phe Thr Thr Ala Phe Phe Phe Ile Gly 
            100                 105                 110         


Phe Phe Gly Ser Ile Phe Phe Ile Thr Val Ile Ser Ile Asp Arg Tyr 
        115                 120                 125             


Leu Ala Ile Val Leu Ala Ala Asn Ser Met Asn Asn Arg Thr Val Gln 
    130                 135                 140                 


His Gly Val Thr Ile Ser Leu Gly Val Trp Ala Ala Ala Ile Leu Val 
145                 150                 155                 160 


Ala Ala Pro Gln Phe Met Phe Thr Lys Gln Lys Glu Asn Glu Cys Leu 
                165                 170                 175     


Gly Asp Tyr Pro Glu Val Leu Gln Glu Ile Trp Pro Val Leu Arg Asn 
            180                 185                 190         


Val Glu Thr Asn Phe Leu Gly Phe Leu Leu Pro Leu Leu Ile Met Ser 
        195                 200                 205             


Tyr Cys Tyr Phe Arg Ile Ile Gln Thr Leu Phe Ser Cys Lys Asn His 
    210                 215                 220                 


Lys Lys Ala Lys Ala Ile Lys Leu Ile Leu Leu Val Val Ile Val Phe 
225                 230                 235                 240 


Phe Leu Phe Trp Thr Pro Tyr Asn Val Met Ile Phe Leu Glu Thr Leu 
                245                 250                 255     


Lys Leu Tyr Asp Phe Phe Pro Ser Cys Asp Met Arg Lys Asp Leu Arg 
            260                 265                 270         


Leu Ala Leu Ser Val Thr Glu Thr Val Ala Phe Ser His Cys Cys Leu 
        275                 280                 285             


Asn Pro Leu Ile Tyr Ala Phe Ala Gly Glu Lys Phe Arg Arg Tyr Leu 
    290                 295                 300                 


Tyr His Leu Tyr Gly Lys Cys Leu Ala Val Leu Cys Gly Arg Ser Val 
305                 310                 315                 320 


His Val Asp Phe Ser Ser Ser Glu Ser Gln Arg Ser Arg His Gly Ser 
                325                 330                 335     


Val Leu Ser Ser Asn Phe Thr Tyr His Thr Ser Asp Gly Asp Ala Leu 
            340                 345                 350         


Leu Leu Leu 
        355 


<210>  496
<211>  355
<212>  PRT
<213>  Homo sapiens

<400>  496

Met Asp Gln Phe Pro Glu Ser Val Thr Glu Asn Phe Glu Tyr Asp Asp 
1               5                   10                  15      


Leu Ala Glu Ala Cys Tyr Ile Gly Asp Ile Val Val Phe Gly Thr Val 
            20                  25                  30          


Phe Leu Ser Ile Phe Tyr Ser Val Ile Phe Ala Ile Gly Leu Val Gly 
        35                  40                  45              


Asn Leu Leu Val Val Phe Ala Leu Thr Asn Ser Lys Lys Pro Lys Ser 
    50                  55                  60                  


Val Thr Asp Ile Tyr Leu Leu Asn Leu Ala Leu Ser Asp Leu Leu Phe 
65                  70                  75                  80  


Val Ala Thr Leu Pro Phe Trp Thr His Tyr Leu Ile Asn Glu Lys Gly 
                85                  90                  95      


Leu His Asn Ala Met Cys Lys Phe Thr Thr Ala Phe Phe Phe Ile Gly 
            100                 105                 110         


Phe Phe Gly Ser Ile Phe Phe Ile Thr Val Ile Ser Ile Asp Arg Tyr 
        115                 120                 125             


Leu Ala Ile Val Leu Ala Ala Asn Ser Met Asn Asn Arg Thr Val Gln 
    130                 135                 140                 


His Gly Val Thr Ile Ser Leu Gly Val Trp Ala Ala Ala Ile Leu Val 
145                 150                 155                 160 


Ala Ala Pro Gln Phe Met Phe Thr Lys Gln Lys Glu Asn Glu Cys Leu 
                165                 170                 175     


Gly Asp Tyr Pro Glu Val Leu Gln Glu Ile Trp Pro Val Leu Arg Asn 
            180                 185                 190         


Val Glu Thr Asn Phe Leu Gly Phe Leu Leu Pro Leu Leu Ile Met Ser 
        195                 200                 205             


Tyr Cys Tyr Phe Arg Ile Ile Gln Thr Leu Phe Ser Cys Lys Asn His 
    210                 215                 220                 


Lys Lys Ala Lys Ala Ile Lys Leu Ile Leu Leu Val Val Ile Val Phe 
225                 230                 235                 240 


Phe Leu Phe Trp Thr Pro Tyr Asn Val Met Ile Phe Leu Glu Thr Leu 
                245                 250                 255     


Lys Leu Tyr Asp Phe Phe Pro Ser Cys Asp Met Arg Lys Asp Leu Arg 
            260                 265                 270         


Leu Ala Leu Ser Val Thr Glu Thr Val Ala Phe Ser His Cys Cys Leu 
        275                 280                 285             


Asn Pro Leu Ile Tyr Ala Phe Ala Gly Glu Lys Phe Arg Arg Tyr Leu 
    290                 295                 300                 


Tyr His Leu Tyr Gly Lys Cys Leu Ala Val Leu Cys Gly Arg Ser Val 
305                 310                 315                 320 


His Val Asp Phe Ser Ser Ser Glu Ser Gln Arg Ser Arg His Gly Ser 
                325                 330                 335     


Val Leu Ser Ser Asn Phe Thr Tyr His Thr Ser Asp Gly Asp Ala Leu 
            340                 345                 350         


Leu Leu Leu 
        355 


<210>  497
<211>  268
<212>  PRT
<213>  Homo sapiens

<400>  497

Met Ser Gly Lys His Tyr Lys Gly Pro Glu Val Ser Cys Cys Ile Lys 
1               5                   10                  15      


Tyr Phe Ile Phe Gly Phe Asn Val Ile Phe Trp Phe Leu Gly Ile Thr 
            20                  25                  30          


Phe Leu Gly Ile Gly Leu Trp Ala Trp Asn Glu Lys Gly Val Leu Ser 
        35                  40                  45              


Asn Ile Ser Ser Ile Thr Asp Leu Gly Gly Phe Asp Pro Val Trp Leu 
    50                  55                  60                  


Phe Leu Val Val Gly Gly Val Met Phe Ile Leu Gly Phe Ala Gly Cys 
65                  70                  75                  80  


Ile Gly Ala Leu Arg Glu Asn Thr Phe Leu Leu Lys Phe Phe Ser Val 
                85                  90                  95      


Phe Leu Gly Ile Ile Phe Phe Leu Glu Leu Thr Ala Gly Val Leu Ala 
            100                 105                 110         


Phe Val Phe Lys Asp Trp Ile Lys Asp Gln Leu Tyr Phe Phe Ile Asn 
        115                 120                 125             


Asn Asn Ile Arg Ala Tyr Arg Asp Asp Ile Asp Leu Gln Asn Leu Ile 
    130                 135                 140                 


Asp Phe Thr Gln Glu Tyr Trp Gln Cys Cys Gly Ala Phe Gly Ala Asp 
145                 150                 155                 160 


Asp Trp Asn Leu Asn Ile Tyr Phe Asn Cys Thr Asp Ser Asn Ala Ser 
                165                 170                 175     


Arg Glu Arg Cys Gly Val Pro Phe Ser Cys Cys Thr Lys Asp Pro Ala 
            180                 185                 190         


Glu Asp Val Ile Asn Thr Gln Cys Gly Tyr Asp Ala Arg Gln Lys Pro 
        195                 200                 205             


Glu Val Asp Gln Gln Ile Val Ile Tyr Thr Lys Gly Cys Val Pro Gln 
    210                 215                 220                 


Phe Glu Lys Trp Leu Gln Asp Asn Leu Thr Ile Val Ala Gly Ile Phe 
225                 230                 235                 240 


Ile Gly Ile Ala Leu Leu Gln Ile Phe Gly Ile Cys Leu Ala Gln Asn 
                245                 250                 255     


Leu Val Ser Asp Ile Glu Ala Val Arg Ala Ser Trp 
            260                 265             


<210>  498
<211>  197
<212>  PRT
<213>  Homo sapiens

<400>  498

Met Phe Ile Leu Gly Phe Ala Gly Cys Ile Gly Ala Leu Arg Glu Asn 
1               5                   10                  15      


Thr Phe Leu Leu Lys Phe Phe Ser Val Phe Leu Gly Ile Ile Phe Phe 
            20                  25                  30          


Leu Glu Leu Thr Ala Gly Val Leu Ala Phe Val Phe Lys Asp Trp Ile 
        35                  40                  45              


Lys Asp Gln Leu Tyr Phe Phe Ile Asn Asn Asn Ile Arg Ala Tyr Arg 
    50                  55                  60                  


Asp Asp Ile Asp Leu Gln Asn Leu Ile Asp Phe Thr Gln Glu Tyr Trp 
65                  70                  75                  80  


Gln Cys Cys Gly Ala Phe Gly Ala Asp Asp Trp Asn Leu Asn Ile Tyr 
                85                  90                  95      


Phe Asn Cys Thr Asp Ser Asn Ala Ser Arg Glu Arg Cys Gly Val Pro 
            100                 105                 110         


Phe Ser Cys Cys Thr Lys Asp Pro Ala Glu Asp Val Ile Asn Thr Gln 
        115                 120                 125             


Cys Gly Tyr Asp Ala Arg Gln Lys Pro Glu Val Asp Gln Gln Ile Val 
    130                 135                 140                 


Ile Tyr Thr Lys Gly Cys Val Pro Gln Phe Glu Lys Trp Leu Gln Asp 
145                 150                 155                 160 


Asn Leu Thr Ile Val Ala Gly Ile Phe Ile Gly Ile Ala Leu Leu Gln 
                165                 170                 175     


Ile Phe Gly Ile Cys Leu Ala Gln Asn Leu Val Ser Asp Ile Glu Ala 
            180                 185                 190         


Val Arg Ala Ser Trp 
        195         


<210>  499
<211>  193
<212>  PRT
<213>  Homo sapiens

<400>  499

Met Ser Gly Lys His Tyr Lys Gly Pro Glu Val Ser Cys Cys Ile Lys 
1               5                   10                  15      


Tyr Phe Ile Phe Gly Phe Asn Val Ile Phe Trp Phe Leu Gly Ile Thr 
            20                  25                  30          


Phe Leu Gly Ile Gly Leu Trp Ala Trp Asn Glu Lys Gly Val Leu Ser 
        35                  40                  45              


Asn Ile Ser Ser Ile Thr Asp Leu Gly Gly Phe Asp Pro Val Trp Leu 
    50                  55                  60                  


Phe Leu Val Val Gly Gly Val Met Phe Ile Leu Gly Phe Ala Gly Cys 
65                  70                  75                  80  


Ile Gly Ala Leu Arg Glu Asn Thr Phe Leu Leu Lys Phe Phe Ser Val 
                85                  90                  95      


Phe Leu Gly Ile Ile Phe Phe Leu Glu Leu Thr Ala Gly Val Leu Ala 
            100                 105                 110         


Phe Val Phe Lys Asp Trp Ile Lys Asp Gln Leu Tyr Phe Phe Ile Asn 
        115                 120                 125             


Asn Asn Ile Arg Ala Tyr Arg Asp Asp Ile Asp Leu Gln Asn Leu Ile 
    130                 135                 140                 


Asp Phe Thr Gln Glu Tyr Ile Pro Met Gln Val Glu Ser Asp Val Ala 
145                 150                 155                 160 


Phe His Ser Pro Ala Ala Leu Lys Ile Pro Gln Lys Met Ser Ser Thr 
                165                 170                 175     


Leu Ser Val Ala Met Met Pro Gly Lys Asn Gln Lys Leu Thr Ser Arg 
            180                 185                 190         


Leu 
    


<210>  500
<211>  60
<212>  PRT
<213>  Homo sapiens

<400>  500

Met Phe Ile Leu Gly Phe Ala Gly Cys Ile Gly Ala Leu Arg Glu Asn 
1               5                   10                  15      


Thr Phe Leu Leu Lys Phe Phe Ser Val Phe Leu Gly Ile Ile Phe Phe 
            20                  25                  30          


Leu Glu Leu Thr Ala Gly Val Leu Ala Phe Val Phe Lys Asp Trp Ile 
        35                  40                  45              


Lys Asp Gln Leu Tyr Phe Phe Ile Asn Asn Asn Ile 
    50                  55                  60  


<210>  501
<211>  38
<212>  PRT
<213>  Homo sapiens

<400>  501

Met Phe Ile Leu Gly Phe Ala Gly Cys Ile Gly Ala Leu Arg Glu Asn 
1               5                   10                  15      


Thr Phe Leu Leu Lys Phe Leu Lys Ser Pro Val Leu Thr Glu Gln Ala 
            20                  25                  30          


Glu Asn Tyr Thr Phe Leu 
        35              


<210>  502
<211>  110
<212>  PRT
<213>  Homo sapiens

<400>  502

Met Phe Ile Leu Gly Phe Ala Gly Cys Ile Gly Ala Leu Arg Glu Asn 
1               5                   10                  15      


Thr Phe Leu Leu Lys Phe Phe Ser Val Phe Leu Gly Ile Ile Phe Phe 
            20                  25                  30          


Leu Glu Leu Thr Ala Gly Val Leu Ala Phe Val Phe Lys Asp Trp Ile 
        35                  40                  45              


Lys Asp Gln Leu Tyr Phe Phe Ile Asn Asn Asn Ile Arg Ala Tyr Arg 
    50                  55                  60                  


Asp Asp Ile Asp Leu Gln Asn Leu Ile Asp Phe Thr Gln Glu Tyr Trp 
65                  70                  75                  80  


Gln Cys Cys Gly Ala Phe Gly Ala Asp Asp Trp Asn Leu Asn Ile Tyr 
                85                  90                  95      


Phe Asn Cys Thr Asp Ser Asn Ala Ser Arg Glu Arg Cys Gly 
            100                 105                 110 


<210>  503
<211>  87
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  503

Xaa Val Ser Cys Cys Ile Lys Tyr Phe Ile Phe Gly Phe Asn Val Ile 
1               5                   10                  15      


Phe Trp Phe Leu Gly Ile Thr Phe Leu Gly Ile Gly Leu Trp Ala Trp 
            20                  25                  30          


Asn Glu Lys Gly Val Leu Ser Asn Ile Ser Ser Ile Thr Asp Leu Gly 
        35                  40                  45              


Gly Phe Asp Pro Val Trp Leu Phe Leu Val Val Gly Gly Val Met Phe 
    50                  55                  60                  


Ile Leu Gly Phe Ala Gly Cys Ile Gly Ala Leu Arg Glu Asn Thr Phe 
65                  70                  75                  80  


Leu Leu Lys Phe Asp Lys Gln 
                85          


<210>  504
<211>  29
<212>  PRT
<213>  Homo sapiens

<400>  504

Ser Phe Ala Ser Leu Lys Ser Gly Thr Cys Ala Cys Thr Gln Thr Gly 
1               5                   10                  15      


Arg Ala Gly Glu Ala Gly Gly Leu Arg Lys Ala Gly Ser 
            20                  25                  


<210>  505
<211>  37
<212>  PRT
<213>  Homo sapiens

<400>  505

Met Leu Leu Tyr Pro Ala Gly Phe Ser Phe Ala Ser Leu Lys Ser Gly 
1               5                   10                  15      


Thr Cys Ala Cys Thr Gln Thr Gly Arg Ala Gly Glu Ala Gly Gly Leu 
            20                  25                  30          


Arg Lys Ala Gly Ser 
        35          


<210>  506
<211>  677
<212>  PRT
<213>  Homo sapiens

<400>  506

Met Pro Gly Phe Leu Val Arg Ile Leu Pro Leu Leu Leu Val Leu Leu 
1               5                   10                  15      


Leu Leu Gly Pro Thr Arg Gly Leu Arg Asn Ala Thr Gln Arg Met Phe 
            20                  25                  30          


Glu Ile Asp Tyr Ser Arg Asp Ser Phe Leu Lys Asp Gly Gln Pro Phe 
        35                  40                  45              


Arg Tyr Ile Ser Gly Ser Ile His Tyr Ser Arg Val Pro Arg Phe Tyr 
    50                  55                  60                  


Trp Lys Asp Arg Leu Leu Lys Met Lys Met Ala Gly Leu Asn Ala Ile 
65                  70                  75                  80  


Gln Thr Tyr Val Pro Trp Asn Phe His Glu Pro Trp Pro Gly Gln Tyr 
                85                  90                  95      


Gln Phe Ser Glu Asp His Asp Val Glu Tyr Phe Leu Arg Leu Ala His 
            100                 105                 110         


Glu Leu Gly Leu Leu Val Ile Leu Arg Pro Gly Pro Tyr Ile Cys Ala 
        115                 120                 125             


Glu Trp Glu Met Gly Gly Leu Pro Ala Trp Leu Leu Glu Lys Glu Ser 
    130                 135                 140                 


Ile Leu Leu Arg Ser Ser Asp Pro Asp Tyr Leu Ala Ala Val Asp Lys 
145                 150                 155                 160 


Trp Leu Gly Val Leu Leu Pro Lys Met Lys Pro Leu Leu Tyr Gln Asn 
                165                 170                 175     


Gly Gly Pro Val Ile Thr Val Gln Val Glu Asn Glu Tyr Gly Ser Tyr 
            180                 185                 190         


Phe Ala Cys Asp Phe Asp Tyr Leu Arg Phe Leu Gln Lys Arg Phe Arg 
        195                 200                 205             


His His Leu Gly Asp Asp Val Val Leu Phe Thr Thr Asp Gly Ala His 
    210                 215                 220                 


Lys Thr Phe Leu Lys Cys Gly Ala Leu Gln Gly Leu Tyr Thr Thr Val 
225                 230                 235                 240 


Asp Phe Gly Thr Gly Ser Asn Ile Thr Asp Ala Phe Leu Ser Gln Arg 
                245                 250                 255     


Lys Cys Glu Pro Lys Gly Pro Leu Ile Asn Ser Glu Phe Tyr Thr Gly 
            260                 265                 270         


Trp Leu Asp His Trp Gly Gln Pro His Ser Thr Ile Lys Thr Glu Ala 
        275                 280                 285             


Val Ala Ser Ser Leu Tyr Asp Ile Leu Ala Arg Gly Ala Ser Val Asn 
    290                 295                 300                 


Leu Tyr Met Phe Ile Gly Gly Thr Asn Phe Ala Tyr Trp Asn Gly Ala 
305                 310                 315                 320 


Asn Ser Pro Tyr Ala Ala Gln Pro Thr Ser Tyr Asp Tyr Asp Ala Pro 
                325                 330                 335     


Leu Ser Glu Ala Gly Asp Leu Thr Glu Lys Tyr Phe Ala Leu Arg Asn 
            340                 345                 350         


Ile Ile Gln Lys Phe Glu Lys Val Pro Glu Gly Pro Ile Pro Pro Ser 
        355                 360                 365             


Thr Pro Lys Phe Ala Tyr Gly Lys Val Thr Leu Glu Lys Leu Lys Thr 
    370                 375                 380                 


Val Gly Ala Ala Leu Asp Ile Leu Cys Pro Ser Gly Pro Ile Lys Ser 
385                 390                 395                 400 


Leu Tyr Pro Leu Thr Phe Ile Gln Val Lys Gln His Tyr Gly Phe Val 
                405                 410                 415     


Leu Tyr Arg Thr Thr Leu Pro Gln Asp Cys Ser Asn Pro Ala Pro Leu 
            420                 425                 430         


Ser Ser Pro Leu Asn Gly Val His Asp Arg Ala Tyr Val Ala Val Asp 
        435                 440                 445             


Gly Ile Pro Gln Gly Val Leu Glu Arg Asn Asn Val Ile Thr Leu Asn 
    450                 455                 460                 


Ile Thr Gly Lys Ala Gly Ala Thr Leu Asp Leu Leu Val Glu Asn Met 
465                 470                 475                 480 


Gly Arg Val Asn Tyr Gly Ala Tyr Ile Asn Asp Phe Lys Gly Leu Val 
                485                 490                 495     


Ser Asn Leu Thr Leu Ser Ser Asn Ile Leu Thr Asp Trp Thr Ile Phe 
            500                 505                 510         


Pro Leu Asp Thr Glu Asp Ala Val Cys Ser His Leu Gly Gly Trp Gly 
        515                 520                 525             


His Arg Asp Ser Gly His His Asp Glu Ala Trp Ala His Asn Ser Ser 
    530                 535                 540                 


Asn Tyr Thr Leu Pro Ala Phe Tyr Met Gly Asn Phe Ser Ile Pro Ser 
545                 550                 555                 560 


Gly Ile Pro Asp Leu Pro Gln Asp Thr Phe Ile Gln Phe Pro Gly Trp 
                565                 570                 575     


Thr Lys Gly Gln Val Trp Ile Asn Gly Phe Asn Leu Gly Arg Tyr Trp 
            580                 585                 590         


Pro Ala Arg Gly Pro Gln Leu Thr Leu Phe Val Pro Gln His Ile Leu 
        595                 600                 605             


Met Thr Ser Ala Pro Asn Thr Ile Thr Val Leu Glu Leu Glu Trp Ala 
    610                 615                 620                 


Pro Cys Ser Ser Asp Asp Pro Glu Leu Cys Ala Val Thr Phe Val Asp 
625                 630                 635                 640 


Arg Pro Val Ile Gly Ser Ser Val Thr Tyr Asp His Pro Ser Lys Pro 
                645                 650                 655     


Val Glu Lys Arg Leu Met Pro Pro Pro Pro Gln Lys Asn Lys Asp Ser 
            660                 665                 670         


Trp Leu Asp His Val 
        675         


<210>  507
<211>  546
<212>  PRT
<213>  Homo sapiens

<400>  507

Met Pro Gly Phe Leu Val Arg Ile Leu Pro Leu Leu Leu Val Leu Leu 
1               5                   10                  15      


Leu Leu Gly Pro Thr Arg Gly Leu Arg Asn Ala Thr Gln Arg Met Phe 
            20                  25                  30          


Glu Ile Asp Tyr Ser Arg Asp Ser Phe Leu Lys Asp Gly Gln Pro Phe 
        35                  40                  45              


Arg Tyr Ile Ser Gly Ser Ile His Tyr Ser Arg Val Pro Arg Phe Tyr 
    50                  55                  60                  


Trp Lys Asp Arg Leu Leu Lys Met Lys Met Ala Gly Leu Asn Ala Ile 
65                  70                  75                  80  


Gln Thr Leu Pro Gly Ser Cys Gly Gln Val Val Gly Ser Pro Ser Ala 
                85                  90                  95      


Gln Asp Glu Ala Ser Pro Leu Ser Glu Trp Arg Ala Ser Tyr Asn Ser 
            100                 105                 110         


Ala Gly Ser Asn Ile Thr Asp Ala Phe Leu Ser Gln Arg Lys Cys Glu 
        115                 120                 125             


Pro Lys Gly Pro Leu Ile Asn Ser Glu Phe Tyr Thr Gly Trp Leu Asp 
    130                 135                 140                 


His Trp Gly Gln Pro His Ser Thr Ile Lys Thr Glu Ala Val Ala Ser 
145                 150                 155                 160 


Ser Leu Tyr Asp Ile Leu Ala Arg Gly Ala Ser Val Asn Leu Tyr Met 
                165                 170                 175     


Phe Ile Gly Gly Thr Asn Phe Ala Tyr Trp Asn Gly Ala Asn Ser Pro 
            180                 185                 190         


Tyr Ala Ala Gln Pro Thr Ser Tyr Asp Tyr Asp Ala Pro Leu Ser Glu 
        195                 200                 205             


Ala Gly Asp Leu Thr Glu Lys Tyr Phe Ala Leu Arg Asn Ile Ile Gln 
    210                 215                 220                 


Lys Phe Glu Lys Val Pro Glu Gly Pro Ile Pro Pro Ser Thr Pro Lys 
225                 230                 235                 240 


Phe Ala Tyr Gly Lys Val Thr Leu Glu Lys Leu Lys Thr Val Gly Ala 
                245                 250                 255     


Ala Leu Asp Ile Leu Cys Pro Ser Gly Pro Ile Lys Ser Leu Tyr Pro 
            260                 265                 270         


Leu Thr Phe Ile Gln Val Lys Gln His Tyr Gly Phe Val Leu Tyr Arg 
        275                 280                 285             


Thr Thr Leu Pro Gln Asp Cys Ser Asn Pro Ala Pro Leu Ser Ser Pro 
    290                 295                 300                 


Leu Asn Gly Val His Asp Arg Ala Tyr Val Ala Val Asp Gly Ile Pro 
305                 310                 315                 320 


Gln Gly Val Leu Glu Arg Asn Asn Val Ile Thr Leu Asn Ile Thr Gly 
                325                 330                 335     


Lys Ala Gly Ala Thr Leu Asp Leu Leu Val Glu Asn Met Gly Arg Val 
            340                 345                 350         


Asn Tyr Gly Ala Tyr Ile Asn Asp Phe Lys Gly Leu Val Ser Asn Leu 
        355                 360                 365             


Thr Leu Ser Ser Asn Ile Leu Thr Asp Trp Thr Ile Phe Pro Leu Asp 
    370                 375                 380                 


Thr Glu Asp Ala Val Cys Ser His Leu Gly Gly Trp Gly His Arg Asp 
385                 390                 395                 400 


Ser Gly His His Asp Glu Ala Trp Ala His Asn Ser Ser Asn Tyr Thr 
                405                 410                 415     


Leu Pro Ala Phe Tyr Met Gly Asn Phe Ser Ile Pro Ser Gly Ile Pro 
            420                 425                 430         


Asp Leu Pro Gln Asp Thr Phe Ile Gln Phe Pro Gly Trp Thr Lys Gly 
        435                 440                 445             


Gln Val Trp Ile Asn Gly Phe Asn Leu Gly Arg Tyr Trp Pro Ala Arg 
    450                 455                 460                 


Gly Pro Gln Leu Thr Leu Phe Val Pro Gln His Ile Leu Met Thr Ser 
465                 470                 475                 480 


Ala Pro Asn Thr Ile Thr Val Leu Glu Leu Glu Trp Ala Pro Cys Ser 
                485                 490                 495     


Ser Asp Asp Pro Glu Leu Cys Ala Val Thr Phe Val Asp Arg Pro Val 
            500                 505                 510         


Ile Gly Ser Ser Val Thr Tyr Asp His Pro Ser Lys Pro Val Glu Lys 
        515                 520                 525             


Arg Leu Met Pro Pro Pro Pro Gln Lys Asn Lys Asp Ser Trp Leu Asp 
    530                 535                 540                 


His Val 
545     


<210>  508
<211>  647
<212>  PRT
<213>  Homo sapiens

<400>  508

Met Phe Glu Ile Asp Tyr Ser Arg Asp Ser Phe Leu Lys Asp Gly Gln 
1               5                   10                  15      


Pro Phe Arg Tyr Ile Ser Gly Ser Ile His Tyr Ser Arg Val Pro Arg 
            20                  25                  30          


Phe Tyr Trp Lys Asp Arg Leu Leu Lys Met Lys Met Ala Gly Leu Asn 
        35                  40                  45              


Ala Ile Gln Thr Tyr Val Pro Trp Asn Phe His Glu Pro Trp Pro Gly 
    50                  55                  60                  


Gln Tyr Gln Phe Ser Glu Asp His Asp Val Glu Tyr Phe Leu Arg Leu 
65                  70                  75                  80  


Ala His Glu Leu Gly Leu Leu Val Ile Leu Arg Pro Gly Pro Tyr Ile 
                85                  90                  95      


Cys Ala Glu Trp Glu Met Gly Gly Leu Pro Ala Trp Leu Leu Glu Lys 
            100                 105                 110         


Glu Ser Ile Leu Leu Arg Ser Ser Asp Pro Asp Tyr Leu Ala Ala Val 
        115                 120                 125             


Asp Lys Trp Leu Gly Val Leu Leu Pro Lys Met Lys Pro Leu Leu Tyr 
    130                 135                 140                 


Gln Asn Gly Gly Pro Val Ile Thr Val Gln Val Glu Asn Glu Tyr Gly 
145                 150                 155                 160 


Ser Tyr Phe Ala Cys Asp Phe Asp Tyr Leu Arg Phe Leu Gln Lys Arg 
                165                 170                 175     


Phe Arg His His Leu Gly Asp Asp Val Val Leu Phe Thr Thr Asp Gly 
            180                 185                 190         


Ala His Lys Thr Phe Leu Lys Cys Gly Ala Leu Gln Gly Leu Tyr Thr 
        195                 200                 205             


Thr Val Asp Phe Gly Thr Gly Ser Asn Ile Thr Asp Ala Phe Leu Ser 
    210                 215                 220                 


Gln Arg Lys Cys Glu Pro Lys Gly Pro Leu Ile Asn Ser Glu Phe Tyr 
225                 230                 235                 240 


Thr Gly Trp Leu Asp His Trp Gly Gln Pro His Ser Thr Ile Lys Thr 
                245                 250                 255     


Glu Ala Val Ala Ser Ser Leu Tyr Asp Ile Leu Ala Arg Gly Ala Ser 
            260                 265                 270         


Val Asn Leu Tyr Met Phe Ile Gly Gly Thr Asn Phe Ala Tyr Trp Asn 
        275                 280                 285             


Gly Ala Asn Ser Pro Tyr Ala Ala Gln Pro Thr Ser Tyr Asp Tyr Asp 
    290                 295                 300                 


Ala Pro Leu Ser Glu Ala Gly Asp Leu Thr Glu Lys Tyr Phe Ala Leu 
305                 310                 315                 320 


Arg Asn Ile Ile Gln Lys Phe Glu Lys Val Pro Glu Gly Pro Ile Pro 
                325                 330                 335     


Pro Ser Thr Pro Lys Phe Ala Tyr Gly Lys Val Thr Leu Glu Lys Leu 
            340                 345                 350         


Lys Thr Val Gly Ala Ala Leu Asp Ile Leu Cys Pro Ser Gly Pro Ile 
        355                 360                 365             


Lys Ser Leu Tyr Pro Leu Thr Phe Ile Gln Val Lys Gln His Tyr Gly 
    370                 375                 380                 


Phe Val Leu Tyr Arg Thr Thr Leu Pro Gln Asp Cys Ser Asn Pro Ala 
385                 390                 395                 400 


Pro Leu Ser Ser Pro Leu Asn Gly Val His Asp Arg Ala Tyr Val Ala 
                405                 410                 415     


Val Asp Gly Ile Pro Gln Gly Val Leu Glu Arg Asn Asn Val Ile Thr 
            420                 425                 430         


Leu Asn Ile Thr Gly Lys Ala Gly Ala Thr Leu Asp Leu Leu Val Glu 
        435                 440                 445             


Asn Met Gly Arg Val Asn Tyr Gly Ala Tyr Ile Asn Asp Phe Lys Gly 
    450                 455                 460                 


Leu Val Ser Asn Leu Thr Leu Ser Ser Asn Ile Leu Thr Asp Trp Thr 
465                 470                 475                 480 


Ile Phe Pro Leu Asp Thr Glu Asp Ala Val Cys Ser His Leu Gly Gly 
                485                 490                 495     


Trp Gly His Arg Asp Ser Gly His His Asp Glu Ala Trp Ala His Asn 
            500                 505                 510         


Ser Ser Asn Tyr Thr Leu Pro Ala Phe Tyr Met Gly Asn Phe Ser Ile 
        515                 520                 525             


Pro Ser Gly Ile Pro Asp Leu Pro Gln Asp Thr Phe Ile Gln Phe Pro 
    530                 535                 540                 


Gly Trp Thr Lys Gly Gln Val Trp Ile Asn Gly Phe Asn Leu Gly Arg 
545                 550                 555                 560 


Tyr Trp Pro Ala Arg Gly Pro Gln Leu Thr Leu Phe Val Pro Gln His 
                565                 570                 575     


Ile Leu Met Thr Ser Ala Pro Asn Thr Ile Thr Val Leu Glu Leu Glu 
            580                 585                 590         


Trp Ala Pro Cys Ser Ser Asp Asp Pro Glu Leu Cys Ala Val Thr Phe 
        595                 600                 605             


Val Asp Arg Pro Val Ile Gly Ser Ser Val Thr Tyr Asp His Pro Ser 
    610                 615                 620                 


Lys Pro Val Glu Lys Arg Leu Met Pro Pro Pro Pro Gln Lys Asn Lys 
625                 630                 635                 640 


Asp Ser Trp Leu Asp His Val 
                645         


<210>  509
<211>  185
<212>  PRT
<213>  Homo sapiens

<400>  509

Met Pro Gly Phe Leu Val Arg Ile Leu Pro Leu Leu Leu Val Leu Leu 
1               5                   10                  15      


Leu Leu Gly Pro Thr Arg Gly Leu Arg Val Glu Asn Glu Tyr Gly Ser 
            20                  25                  30          


Tyr Phe Ala Cys Asp Phe Asp Tyr Leu Arg Phe Leu Gln Lys Arg Phe 
        35                  40                  45              


Arg His His Leu Gly Asp Asp Val Val Leu Phe Thr Thr Asp Gly Ala 
    50                  55                  60                  


His Lys Thr Phe Leu Lys Cys Gly Ala Leu Gln Gly Leu Tyr Thr Thr 
65                  70                  75                  80  


Val Asp Phe Gly Thr Gly Ser Asn Ile Thr Asp Ala Phe Leu Ser Gln 
                85                  90                  95      


Arg Lys Cys Glu Pro Lys Gly Pro Leu Ile Asn Ser Glu Phe Tyr Thr 
            100                 105                 110         


Gly Trp Leu Asp His Trp Gly Gln Pro His Ser Thr Ile Lys Thr Glu 
        115                 120                 125             


Ala Val Ala Ser Ser Leu Tyr Asp Ile Leu Ala Arg Gly Ala Ser Val 
    130                 135                 140                 


Asn Leu Tyr Met Phe Ile Gly Gly Thr Asn Phe Ala Tyr Trp Asn Gly 
145                 150                 155                 160 


Ala Asn Ser Pro Tyr Ala Ala Gln Pro Thr Ser Tyr Asp Tyr Asp Ala 
                165                 170                 175     


Pro Leu Ser Glu Ala Gly Asp Leu Thr 
            180                 185 


<210>  510
<211>  147
<212>  PRT
<213>  Homo sapiens

<400>  510

Met Pro Gly Phe Leu Val Arg Ile Leu Pro Leu Leu Leu Val Leu Leu 
1               5                   10                  15      


Leu Leu Gly Pro Thr Arg Gly Leu Arg Ser Arg Phe Leu Pro Trp Ala 
            20                  25                  30          


Phe His Leu Pro Arg Gln Ala Pro Lys Ser Gln Leu Pro Leu His Lys 
        35                  40                  45              


Arg Gly Thr Lys Thr Ala Pro Asn Glu His Ala Ser Ser Asn Arg Ser 
    50                  55                  60                  


Gly Arg Arg Arg Arg Arg Gln Gln Trp Asn Ala Thr Gln Arg Met Phe 
65                  70                  75                  80  


Glu Ile Asp Tyr Ser Arg Asp Ser Phe Leu Lys Asp Gly Gln Pro Phe 
                85                  90                  95      


Arg Tyr Ile Ser Gly Ser Ile His Tyr Ser Arg Val Pro Arg Phe Tyr 
            100                 105                 110         


Trp Lys Asp Arg Leu Leu Lys Met Lys Met Ala Gly Leu Asn Ala Ile 
        115                 120                 125             


Gln Thr Tyr Val Pro Trp Asn Phe His Glu Pro Trp Pro Gly Gln Tyr 
    130                 135                 140                 


Gln Phe Ser 
145         


<210>  511
<211>  41
<212>  PRT
<213>  Homo sapiens

<400>  511

Met Pro Gly Phe Leu Val Arg Ile Leu Pro Leu Leu Leu Val Leu Leu 
1               5                   10                  15      


Leu Leu Gly Pro Thr Arg Gly Leu Arg Ile Thr Trp Gln Leu Trp Thr 
            20                  25                  30          


Ser Gly Trp Glu Ser Phe Cys Pro Arg 
        35                  40      


<210>  512
<211>  114
<212>  PRT
<213>  Homo sapiens

<400>  512

Met Gly Gly Leu Pro Ala Trp Leu Leu Glu Lys Glu Ser Ile Leu Leu 
1               5                   10                  15      


Arg Ser Ser Asp Pro Asp Tyr Leu Ala Ala Val Asp Lys Trp Leu Gly 
            20                  25                  30          


Val Leu Leu Pro Lys Met Lys Pro Leu Leu Tyr Gln Asn Gly Gly Pro 
        35                  40                  45              


Val Ile Thr Val Gln Val Glu Asn Glu Tyr Gly Ser Tyr Phe Ala Cys 
    50                  55                  60                  


Asp Phe Asp Tyr Leu Arg Phe Leu Gln Lys Arg Phe Arg His His Leu 
65                  70                  75                  80  


Gly Asp Asp Val Val Leu Phe Thr Thr Asp Gly Ala His Lys Thr Phe 
                85                  90                  95      


Leu Lys Cys Gly Ala Leu Gln Gly Leu Tyr Thr Thr Val Asp Phe Gly 
            100                 105                 110         


Thr Gly 
        


<210>  513
<211>  84
<212>  PRT
<213>  Homo sapiens

<400>  513

Met Phe Glu Ile Asp Tyr Ser Arg Asp Ser Phe Leu Lys Asp Gly Gln 
1               5                   10                  15      


Pro Phe Arg Tyr Ile Ser Gly Ser Ile His Tyr Ser Arg Val Pro Arg 
            20                  25                  30          


Phe Tyr Trp Lys Asp Arg Leu Leu Lys Met Lys Met Ala Gly Leu Asn 
        35                  40                  45              


Ala Ile Gln Thr Leu Pro Gly Ser Cys Gly Gln Val Val Gly Ser Pro 
    50                  55                  60                  


Ser Ala Gln Asp Glu Ala Ser Pro Leu Ser Glu Trp Arg Ala Ser Tyr 
65                  70                  75                  80  


Asn Ser Ala Gly 
                


<210>  514
<211>  102
<212>  PRT
<213>  Homo sapiens

<400>  514

Met Phe Glu Ile Asp Tyr Ser Arg Asp Ser Phe Leu Lys Asp Gly Gln 
1               5                   10                  15      


Pro Phe Arg Tyr Ile Ser Gly Ser Ile His Tyr Ser Arg Val Pro Arg 
            20                  25                  30          


Phe Tyr Trp Lys Asp Arg Leu Leu Lys Met Lys Met Ala Gly Leu Asn 
        35                  40                  45              


Ala Ile Gln Thr Tyr Val Pro Trp Asn Phe His Glu Pro Trp Pro Gly 
    50                  55                  60                  


Gln Tyr Gln Phe Ser Glu Asp His Asp Val Glu Tyr Phe Leu Arg Leu 
65                  70                  75                  80  


Ala His Glu Leu Gly Leu Leu Val Ile Leu Arg Pro Gly Pro Tyr Ile 
                85                  90                  95      


Cys Ala Glu Trp Glu Met 
            100         


<210>  515
<211>  150
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  515

Xaa Leu Gly Trp Ser Lys Ala Gly Ser Gly Ser Val Cys Leu Ala Leu 
1               5                   10                  15      


Asp Gln Leu Arg Asp Val Ile Glu Ser Gln Glu Glu Leu Ile His Gln 
            20                  25                  30          


Leu Arg Asn Val Met Val Leu Gln Asp Glu Asn Phe Val Ser Lys Glu 
        35                  40                  45              


Glu Phe Gln Ala Val Glu Lys Lys Leu Val Glu Glu Lys Ala Ala His 
    50                  55                  60                  


Ala Lys Thr Lys Val Leu Leu Ala Lys Glu Glu Glu Lys Leu Gln Phe 
65                  70                  75                  80  


Ala Leu Gly Glu Val Glu Val Leu Ser Lys Gln Leu Glu Lys Glu Lys 
                85                  90                  95      


Leu Ala Phe Glu Lys Ala Leu Ser Ser Val Lys Ser Lys Val Leu Gln 
            100                 105                 110         


Glu Ser Ser Lys Lys Asp Gln Leu Ile Thr Lys Cys Asn Gly Ile Thr 
        115                 120                 125             


Cys Leu Thr Ser Gly Ser Arg Ser Ser Arg Arg Ala Thr Trp Pro Arg 
    130                 135                 140                 


Cys Trp Thr Arg Ser Ile 
145                 150 


<210>  516
<211>  63
<212>  PRT
<213>  Homo sapiens

<400>  516

Met Ala Ala Ser Gly Glu Pro Gln Arg Gln Trp Gln Glu Glu Val Ala 
1               5                   10                  15      


Ala Val Val Val Val Gly Ser Cys Met Thr Asp Leu Val Arg Arg Met 
            20                  25                  30          


Cys Met Arg Ile Cys Tyr Val His Phe Cys Cys Gln Pro Thr Pro Gln 
        35                  40                  45              


Leu Gln Asn Cys Ser Ser Leu Cys Val Ile Thr Cys Gln Glu Asn 
    50                  55                  60              


<210>  517
<211>  518
<212>  PRT
<213>  Homo sapiens

<400>  517

Met Ala Leu Glu Arg Leu Cys Ser Val Leu Lys Val Leu Leu Ile Thr 
1               5                   10                  15      


Val Leu Val Val Glu Gly Ile Ala Val Ala Gln Lys Thr Gln Asp Gly 
            20                  25                  30          


Gln Asn Ile Gly Ile Lys His Ile Pro Ala Thr Gln Cys Gly Ile Trp 
        35                  40                  45              


Val Arg Thr Ser Asn Gly Gly His Phe Ala Ser Pro Asn Tyr Pro Asp 
    50                  55                  60                  


Ser Tyr Pro Pro Asn Lys Glu Cys Ile Tyr Ile Leu Glu Ala Ala Pro 
65                  70                  75                  80  


Arg Gln Arg Ile Glu Leu Thr Phe Asp Glu His Tyr Tyr Ile Glu Pro 
                85                  90                  95      


Ser Phe Glu Cys Arg Phe Asp His Leu Glu Val Arg Asp Gly Pro Phe 
            100                 105                 110         


Gly Phe Ser Pro Leu Ile Asp Arg Tyr Cys Gly Val Lys Ser Pro Pro 
        115                 120                 125             


Leu Ile Arg Ser Thr Gly Arg Phe Met Trp Ile Lys Phe Ser Ser Asp 
    130                 135                 140                 


Glu Glu Leu Glu Gly Leu Gly Phe Arg Ala Lys Tyr Ser Phe Ile Pro 
145                 150                 155                 160 


Asp Pro Asp Phe Thr Tyr Leu Gly Asp Cys Gln Phe Glu Leu Ser Gly 
                165                 170                 175     


Ala Asp Gly Ile Val Arg Ser Ser Gln Val Glu Gln Glu Glu Lys Thr 
            180                 185                 190         


Lys Pro Gly Gln Ala Val Asp Cys Ile Trp Thr Ile Lys Ala Thr Pro 
        195                 200                 205             


Lys Ala Lys Ile Tyr Leu Arg Phe Leu Asp Tyr Gln Met Glu His Ser 
    210                 215                 220                 


Asn Glu Cys Lys Arg Asn Phe Val Ala Val Tyr Asp Gly Ser Ser Ser 
225                 230                 235                 240 


Ile Glu Asn Leu Lys Ala Lys Phe Cys Ser Thr Val Ala Asn Asp Val 
                245                 250                 255     


Met Leu Lys Thr Gly Ile Gly Val Ile Arg Met Trp Ala Asp Glu Gly 
            260                 265                 270         


Ser Arg Leu Ser Arg Phe Arg Met Leu Phe Thr Ser Phe Val Glu Pro 
        275                 280                 285             


Pro Cys Thr Ser Ser Thr Phe Phe Cys His Ser Asn Met Cys Ile Asn 
    290                 295                 300                 


Asn Ser Leu Val Cys Asn Gly Val Gln Asn Cys Ala Tyr Pro Trp Asp 
305                 310                 315                 320 


Glu Asn His Cys Lys Glu Lys Lys Lys Ala Gly Val Phe Glu Gln Ile 
                325                 330                 335     


Thr Lys Thr His Gly Thr Ile Ile Gly Ile Thr Ser Gly Ile Val Leu 
            340                 345                 350         


Val Leu Leu Ile Ile Ser Ile Leu Val Gln Val Lys Gln Pro Arg Lys 
        355                 360                 365             


Lys Val Met Ala Cys Lys Thr Ala Phe Asn Lys Thr Gly Phe Gln Glu 
    370                 375                 380                 


Val Phe Asp Pro Pro His Tyr Glu Leu Phe Ser Leu Arg Asp Lys Glu 
385                 390                 395                 400 


Ile Ser Ala Asp Leu Ala Asp Leu Ser Glu Glu Leu Asp Asn Tyr Gln 
                405                 410                 415     


Lys Met Arg Arg Ser Ser Thr Ala Ser Arg Cys Ile His Asp His His 
            420                 425                 430         


Cys Gly Ser Gln Ala Ser Ser Val Lys Gln Ser Arg Thr Asn Leu Ser 
        435                 440                 445             


Ser Met Glu Leu Pro Phe Arg Asn Asp Phe Ala Gln Pro Gln Pro Met 
    450                 455                 460                 


Lys Thr Phe Asn Ser Thr Phe Lys Lys Ser Ser Tyr Thr Phe Lys Gln 
465                 470                 475                 480 


Gly His Glu Cys Pro Glu Gln Ala Leu Glu Asp Arg Val Met Glu Glu 
                485                 490                 495     


Ile Pro Cys Glu Ile Tyr Val Arg Gly Arg Glu Asp Ser Ala Gln Ala 
            500                 505                 510         


Ser Ile Ser Ile Asp Phe 
        515             


<210>  518
<211>  525
<212>  PRT
<213>  Homo sapiens

<400>  518

Met Ala Leu Glu Arg Leu Cys Ser Val Leu Lys Val Leu Leu Ile Thr 
1               5                   10                  15      


Val Leu Val Val Glu Gly Ile Ala Val Ala Gln Lys Thr Gln Asp Gly 
            20                  25                  30          


Gln Asn Ile Gly Ile Lys His Ile Pro Ala Thr Gln Cys Gly Ile Trp 
        35                  40                  45              


Val Arg Thr Ser Asn Gly Gly His Phe Ala Ser Pro Asn Tyr Pro Asp 
    50                  55                  60                  


Ser Tyr Pro Pro Asn Lys Glu Cys Ile Tyr Ile Leu Glu Ala Ala Pro 
65                  70                  75                  80  


Arg Gln Arg Ile Glu Leu Thr Phe Asp Glu His Tyr Tyr Ile Glu Pro 
                85                  90                  95      


Ser Phe Glu Cys Arg Phe Asp His Leu Glu Val Arg Asp Gly Pro Phe 
            100                 105                 110         


Gly Phe Ser Pro Leu Ile Asp Arg Tyr Cys Gly Val Lys Ser Pro Pro 
        115                 120                 125             


Leu Ile Arg Ser Thr Gly Arg Phe Met Trp Ile Lys Phe Ser Ser Asp 
    130                 135                 140                 


Glu Glu Leu Glu Gly Leu Gly Phe Arg Ala Lys Tyr Ser Phe Ile Pro 
145                 150                 155                 160 


Asp Pro Asp Phe Thr Tyr Leu Gly Gly Ile Leu Asn Pro Ile Pro Asp 
                165                 170                 175     


Cys Gln Phe Glu Leu Ser Gly Ala Asp Gly Ile Val Arg Ser Ser Gln 
            180                 185                 190         


Val Glu Gln Glu Glu Lys Thr Lys Pro Gly Gln Ala Val Asp Cys Ile 
        195                 200                 205             


Trp Thr Ile Lys Ala Thr Pro Lys Ala Lys Ile Tyr Leu Arg Phe Leu 
    210                 215                 220                 


Asp Tyr Gln Met Glu His Ser Asn Glu Cys Lys Arg Asn Phe Val Ala 
225                 230                 235                 240 


Val Tyr Asp Gly Ser Ser Ser Ile Glu Asn Leu Lys Ala Lys Phe Cys 
                245                 250                 255     


Ser Thr Val Ala Asn Asp Val Met Leu Lys Thr Gly Ile Gly Val Ile 
            260                 265                 270         


Arg Met Trp Ala Asp Glu Gly Ser Arg Leu Ser Arg Phe Arg Met Leu 
        275                 280                 285             


Phe Thr Ser Phe Val Glu Pro Pro Cys Thr Ser Ser Thr Phe Phe Cys 
    290                 295                 300                 


His Ser Asn Met Cys Ile Asn Asn Ser Leu Val Cys Asn Gly Val Gln 
305                 310                 315                 320 


Asn Cys Ala Tyr Pro Trp Asp Glu Asn His Cys Lys Glu Lys Lys Lys 
                325                 330                 335     


Ala Gly Val Phe Glu Gln Ile Thr Lys Thr His Gly Thr Ile Ile Gly 
            340                 345                 350         


Ile Thr Ser Gly Ile Val Leu Val Leu Leu Ile Ile Ser Ile Leu Val 
        355                 360                 365             


Gln Val Lys Gln Pro Arg Lys Lys Val Met Ala Cys Lys Thr Ala Phe 
    370                 375                 380                 


Asn Lys Thr Gly Phe Gln Glu Val Phe Asp Pro Pro His Tyr Glu Leu 
385                 390                 395                 400 


Phe Ser Leu Arg Asp Lys Glu Ile Ser Ala Asp Leu Ala Asp Leu Ser 
                405                 410                 415     


Glu Glu Leu Asp Asn Tyr Gln Lys Met Arg Arg Ser Ser Thr Ala Ser 
            420                 425                 430         


Arg Cys Ile His Asp His His Cys Gly Ser Gln Ala Ser Ser Val Lys 
        435                 440                 445             


Gln Ser Arg Thr Asn Leu Ser Ser Met Glu Leu Pro Phe Arg Asn Asp 
    450                 455                 460                 


Phe Ala Gln Pro Gln Pro Met Lys Thr Phe Asn Ser Thr Phe Lys Lys 
465                 470                 475                 480 


Ser Ser Tyr Thr Phe Lys Gln Gly His Glu Cys Pro Glu Gln Ala Leu 
                485                 490                 495     


Glu Asp Arg Val Met Glu Glu Ile Pro Cys Glu Ile Tyr Val Arg Gly 
            500                 505                 510         


Arg Glu Asp Ser Ala Gln Ala Ser Ile Ser Ile Asp Phe 
        515                 520                 525 


<210>  519
<211>  365
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  519

Xaa Leu Ile Asp Arg Tyr Cys Gly Val Lys Ser Pro Pro Leu Ile Arg 
1               5                   10                  15      


Ser Thr Gly Arg Phe Met Trp Ile Lys Phe Ser Ser Asp Glu Glu Leu 
            20                  25                  30          


Glu Gly Leu Gly Phe Arg Ala Lys Tyr Ser Phe Ile Pro Asp Pro Asp 
        35                  40                  45              


Phe Thr Tyr Leu Gly Asp Cys Gln Phe Glu Leu Ser Gly Ala Asp Gly 
    50                  55                  60                  


Ile Val Arg Ser Ser Gln Val Glu Gln Glu Glu Lys Thr Lys Pro Gly 
65                  70                  75                  80  


Gln Ala Val Asp Cys Ile Trp Thr Ile Lys Ala Thr Pro Lys Ala Lys 
                85                  90                  95      


Ile Tyr Leu Arg Phe Leu Asp Tyr Gln Met Glu His Ser Asn Glu Cys 
            100                 105                 110         


Lys Arg Asn Phe Val Ala Val Tyr Asp Gly Ser Ser Ser Ile Glu Asn 
        115                 120                 125             


Leu Lys Ala Lys Phe Cys Ser Thr Val Ala Asn Asp Val Met Leu Lys 
    130                 135                 140                 


Thr Gly Ile Gly Val Ile Arg Met Trp Ala Asp Glu Gly Ser Arg Leu 
145                 150                 155                 160 


Ser Arg Phe Arg Met Leu Phe Thr Ser Phe Val Glu Gln Lys Lys Lys 
                165                 170                 175     


Ala Gly Val Phe Glu Gln Ile Thr Lys Thr His Gly Thr Ile Ile Gly 
            180                 185                 190         


Ile Thr Ser Gly Ile Val Leu Val Leu Leu Ile Ile Ser Ile Leu Val 
        195                 200                 205             


Gln Val Lys Gln Pro Arg Lys Lys Val Met Ala Cys Lys Thr Ala Phe 
    210                 215                 220                 


Asn Lys Thr Gly Phe Gln Glu Val Phe Asp Pro Pro His Tyr Glu Leu 
225                 230                 235                 240 


Phe Ser Leu Arg Asp Lys Glu Ile Ser Ala Asp Leu Ala Asp Leu Ser 
                245                 250                 255     


Glu Glu Leu Asp Asn Tyr Gln Lys Met Arg Arg Ser Ser Thr Ala Ser 
            260                 265                 270         


Arg Cys Ile His Asp His His Cys Gly Ser Gln Ala Ser Ser Val Lys 
        275                 280                 285             


Gln Ser Arg Thr Asn Leu Ser Ser Met Glu Leu Pro Phe Arg Asn Asp 
    290                 295                 300                 


Phe Ala Gln Pro Gln Pro Met Lys Thr Phe Asn Ser Thr Phe Lys Lys 
305                 310                 315                 320 


Ser Ser Tyr Thr Phe Lys Gln Gly His Glu Cys Pro Glu Gln Ala Leu 
                325                 330                 335     


Glu Asp Arg Val Met Glu Glu Ile Pro Cys Glu Ile Tyr Val Arg Gly 
            340                 345                 350         


Arg Glu Asp Ser Ala Gln Ala Ser Ile Ser Ile Asp Phe 
        355                 360                 365 


<210>  520
<211>  194
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  520

Xaa Thr Tyr Leu Gly Gly Ile Leu Asn Pro Ile Pro Asp Cys Gln Phe 
1               5                   10                  15      


Glu Leu Ser Gly Ala Asp Gly Ile Val Arg Ser Ser Gln Val Glu Gln 
            20                  25                  30          


Glu Glu Lys Thr Lys Pro Gly Gln Ala Val Asp Cys Ile Trp Thr Ile 
        35                  40                  45              


Lys Ala Thr Pro Lys Ala Lys Ile Tyr Leu Arg Phe Leu Asp Tyr Gln 
    50                  55                  60                  


Met Glu His Ser Asn Glu Cys Lys Arg Asn Phe Val Ala Val Tyr Asp 
65                  70                  75                  80  


Gly Ser Ser Ser Ile Glu Asn Leu Lys Ala Lys Phe Cys Ser Thr Val 
                85                  90                  95      


Ala Asn Asp Val Met Leu Lys Thr Gly Ile Gly Val Ile Arg Met Trp 
            100                 105                 110         


Ala Asp Glu Gly Ser Arg Leu Ser Arg Phe Arg Met Leu Phe Thr Ser 
        115                 120                 125             


Phe Val Glu Gln Lys Lys Lys Ala Gly Val Phe Glu Gln Ile Thr Lys 
    130                 135                 140                 


Thr His Gly Thr Ile Ile Gly Ile Thr Ser Gly Ile Val Leu Val Leu 
145                 150                 155                 160 


Leu Ile Ile Ser Ile Leu Val Gln Val Lys Gln Pro Arg Lys Lys Val 
                165                 170                 175     


Met Ala Cys Lys Thr Ala Phe Asn Lys Thr Gly Phe Gln Glu Val Phe 
            180                 185                 190         


Asp Pro 
        


<210>  521
<211>  228
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  521

Xaa Ser Ser Ser Ile Glu Asn Leu Lys Ala Lys Phe Cys Ser Thr Val 
1               5                   10                  15      


Ala Asn Asp Val Met Leu Lys Thr Gly Ile Gly Val Ile Arg Met Trp 
            20                  25                  30          


Ala Asp Glu Glu Lys Lys Lys Ala Gly Val Phe Glu Gln Ile Thr Lys 
        35                  40                  45              


Thr His Gly Thr Ile Ile Gly Ile Thr Ser Gly Ile Val Leu Val Leu 
    50                  55                  60                  


Leu Ile Ile Ser Ile Leu Val Gln Val Lys Gln Pro Arg Lys Lys Val 
65                  70                  75                  80  


Met Ala Cys Lys Thr Ala Phe Asn Lys Thr Gly Phe Gln Glu Val Phe 
                85                  90                  95      


Asp Pro Pro His Tyr Glu Leu Phe Ser Leu Arg Asp Lys Glu Ile Ser 
            100                 105                 110         


Ala Asp Leu Ala Asp Leu Ser Glu Glu Leu Asp Asn Tyr Gln Lys Met 
        115                 120                 125             


Arg Arg Ser Ser Thr Ala Ser Arg Cys Ile His Asp His His Cys Gly 
    130                 135                 140                 


Ser Gln Ala Ser Ser Val Lys Gln Ser Arg Thr Asn Leu Ser Ser Met 
145                 150                 155                 160 


Glu Leu Pro Phe Arg Asn Asp Phe Ala Gln Pro Gln Pro Met Lys Thr 
                165                 170                 175     


Phe Asn Ser Thr Phe Lys Lys Ser Ser Tyr Thr Phe Lys Gln Gly His 
            180                 185                 190         


Glu Cys Pro Glu Gln Ala Leu Glu Asp Arg Val Met Glu Glu Ile Pro 
        195                 200                 205             


Cys Glu Ile Tyr Val Arg Gly Arg Glu Asp Ser Ala Gln Ala Ser Ile 
    210                 215                 220                 


Ser Ile Asp Phe 
225             


<210>  522
<211>  347
<212>  PRT
<213>  Homo sapiens

<400>  522

Met Ser Ser Trp Ser Arg Gln Arg Pro Lys Ser Pro Gly Gly Ile Gln 
1               5                   10                  15      


Pro His Val Ser Arg Thr Leu Phe Leu Leu Leu Leu Leu Ala Ala Ser 
            20                  25                  30          


Ala Trp Gly Val Thr Leu Ser Pro Lys Asp Cys Gln Val Phe Arg Ser 
        35                  40                  45              


Asp His Gly Ser Ser Ile Ser Cys Gln Pro Pro Ala Glu Ile Pro Gly 
    50                  55                  60                  


Tyr Leu Pro Ala Asp Thr Val His Leu Ala Val Glu Phe Phe Asn Leu 
65                  70                  75                  80  


Thr His Leu Pro Ala Asn Leu Leu Gln Gly Ala Ser Lys Leu Gln Glu 
                85                  90                  95      


Leu His Leu Ser Ser Asn Gly Leu Glu Ser Leu Ser Pro Glu Phe Leu 
            100                 105                 110         


Arg Pro Val Pro Gln Leu Arg Val Leu Asp Leu Thr Arg Asn Ala Leu 
        115                 120                 125             


Thr Gly Leu Pro Pro Gly Leu Phe Gln Ala Ser Ala Thr Leu Asp Thr 
    130                 135                 140                 


Leu Val Leu Lys Glu Asn Gln Leu Glu Val Leu Glu Val Ser Trp Leu 
145                 150                 155                 160 


His Gly Leu Lys Ala Leu Gly His Leu Asp Leu Ser Gly Asn Arg Leu 
                165                 170                 175     


Arg Lys Leu Pro Pro Gly Leu Leu Ala Asn Phe Thr Leu Leu Arg Thr 
            180                 185                 190         


Leu Asp Leu Gly Glu Asn Gln Leu Glu Thr Leu Pro Pro Asp Leu Leu 
        195                 200                 205             


Arg Gly Pro Leu Gln Leu Glu Arg Leu His Leu Glu Gly Asn Lys Leu 
    210                 215                 220                 


Gln Val Leu Gly Lys Asp Leu Leu Leu Pro Gln Pro Asp Leu Arg Tyr 
225                 230                 235                 240 


Leu Phe Leu Asn Gly Asn Lys Leu Ala Arg Val Ala Ala Gly Ala Phe 
                245                 250                 255     


Gln Gly Leu Arg Gln Leu Asp Met Leu Asp Leu Ser Asn Asn Ser Leu 
            260                 265                 270         


Ala Ser Val Pro Glu Gly Leu Trp Ala Ser Leu Gly Gln Pro Asn Trp 
        275                 280                 285             


Asp Met Arg Asp Gly Phe Asp Ile Ser Gly Asn Pro Trp Ile Cys Asp 
    290                 295                 300                 


Gln Asn Leu Ser Asp Leu Tyr Arg Trp Leu Gln Ala Gln Lys Asp Lys 
305                 310                 315                 320 


Met Phe Ser Gln Asn Asp Thr Arg Cys Ala Gly Pro Glu Ala Val Lys 
                325                 330                 335     


Gly Gln Thr Leu Leu Ala Val Ala Lys Ser Gln 
            340                 345         


<210>  523
<211>  330
<212>  PRT
<213>  Homo sapiens

<400>  523

Met Arg Gly Pro Glu Pro Gly Pro Gln Pro Thr Met Glu Gly Asp Val 
1               5                   10                  15      


Leu Asp Thr Leu Glu Ala Leu Gly Tyr Lys Gly Pro Leu Leu Glu Glu 
            20                  25                  30          


Gln Ala Leu Thr Lys Ala Ala Glu Gly Gly Leu Ser Ser Pro Glu Phe 
        35                  40                  45              


Ser Glu Leu Cys Ile Trp Leu Gly Ser Gln Ile Lys Ser Leu Cys Asn 
    50                  55                  60                  


Leu Glu Glu Ser Ile Thr Ser Ala Gly Arg Asp Asp Leu Glu Ser Phe 
65                  70                  75                  80  


Gln Leu Glu Ile Ser Gly Phe Leu Lys Glu Met Ala Cys Pro Tyr Ser 
                85                  90                  95      


Val Leu Ile Ser Gly Asp Ile Lys Asp Arg Leu Lys Lys Lys Glu Asp 
            100                 105                 110         


Cys Leu Lys Leu Leu Leu Phe Leu Ser Thr Glu Leu Gln Ala Ser Gln 
        115                 120                 125             


Ile Leu Gln Asn Lys Lys His Lys Asn Ser Gln Leu Asp Lys Asn Ser 
    130                 135                 140                 


Glu Val Tyr Gln Glu Val Gln Ala Met Phe Asp Thr Leu Gly Ile Pro 
145                 150                 155                 160 


Lys Ser Thr Thr Ser Asp Ile Pro His Met Leu Asn Gln Val Glu Ser 
                165                 170                 175     


Lys Val Lys Asp Ile Leu Ser Lys Val Gln Lys Asn His Val Gly Lys 
            180                 185                 190         


Pro Leu Leu Lys Met Asp Leu Asn Ser Glu Gln Ala Glu Gln Leu Glu 
        195                 200                 205             


Arg Ile Asn Asp Ala Leu Ser Cys Glu Tyr Glu Cys Arg Arg Arg Met 
    210                 215                 220                 


Leu Met Lys Arg Leu Asp Val Thr Val Gln Ser Phe Gly Trp Ser Asp 
225                 230                 235                 240 


Arg Ala Lys Val Lys Thr Asp Asp Ile Ala Arg Ile Tyr Gln Pro Lys 
                245                 250                 255     


Arg Tyr Ala Leu Ser Pro Lys Thr Thr Ile Thr Met Ala His Leu Leu 
            260                 265                 270         


Ala Ala Arg Glu Asp Leu Ser Lys Ile Ile Arg Thr Ser Ser Gly Thr 
        275                 280                 285             


Ser Arg Glu Lys Thr Ala Cys Ala Ile Asn Lys Val Gly Val Ser Phe 
    290                 295                 300                 


Ser Thr Val Glu Asn Glu Leu Met Ile Ser Tyr Leu Met Phe Leu Gln 
305                 310                 315                 320 


Ile Leu Val Tyr Phe Ser Phe Met Ser Trp 
                325                 330 


<210>  524
<211>  101
<212>  PRT
<213>  Homo sapiens

<400>  524

Ile Ser Gly Asp Ile Lys Asp Arg Leu Lys Lys Lys Glu Asp Cys Leu 
1               5                   10                  15      


Lys Leu Leu Leu Phe Leu Ser Thr Glu Leu Gln Ala Ser Gln Ile Leu 
            20                  25                  30          


Gln Asn Lys Lys His Lys Asn Ser Gln Leu Asp Lys Asn Ser Glu Val 
        35                  40                  45              


Tyr Gln Glu Val Gln Ala Met Phe Asp Thr Leu Gly Ile Pro Lys Ser 
    50                  55                  60                  


Thr Thr Ser Asp Ile Pro His Met Leu Asn Gln Val Glu Ser Lys Val 
65                  70                  75                  80  


Lys Asp Ile Leu Ser Lys Ile His Met Glu Glu Val Val Val Val Val 
                85                  90                  95      


Val Val Val Val Glu 
            100     


<210>  525
<211>  352
<212>  PRT
<213>  Homo sapiens

<400>  525

Met Lys Pro Ala Leu Leu Glu Val Met Arg Met Asn Arg Ile Cys Arg 
1               5                   10                  15      


Met Val Leu Ala Thr Cys Leu Gly Ser Phe Ile Leu Val Ile Phe Tyr 
            20                  25                  30          


Phe Gln Ser Met Leu His Pro Val Met Arg Arg Asn Pro Phe Gly Val 
        35                  40                  45              


Asp Ile Cys Cys Arg Lys Gly Ser Arg Ser Pro Leu Gln Glu Leu Tyr 
    50                  55                  60                  


Asn Pro Ile Gln Leu Glu Leu Ser Asn Thr Ala Val Leu His Gln Met 
65                  70                  75                  80  


Arg Arg Asp Gln Val Thr Asp Thr Cys Arg Ala Asn Ser Ala Thr Ser 
                85                  90                  95      


Arg Lys Arg Arg Val Leu Thr Pro Asn Asp Leu Lys His Leu Val Val 
            100                 105                 110         


Asp Glu Asp His Glu Leu Ile Tyr Cys Tyr Val Pro Lys Val Ala Cys 
        115                 120                 125             


Thr Asn Trp Lys Arg Leu Met Met Val Leu Thr Gly Arg Gly Lys Tyr 
    130                 135                 140                 


Ser Asp Pro Met Glu Ile Pro Ala Asn Glu Ala His Val Ser Ala Asn 
145                 150                 155                 160 


Leu Lys Thr Leu Asn Gln Tyr Ser Ile Pro Glu Ile Asn His Arg Leu 
                165                 170                 175     


Lys Ser Tyr Met Lys Phe Leu Phe Val Arg Glu Pro Phe Glu Arg Leu 
            180                 185                 190         


Val Ser Ala Tyr Arg Asn Lys Phe Thr Gln Lys Tyr Asn Ile Ser Phe 
        195                 200                 205             


His Lys Arg Tyr Gly Thr Lys Ile Ile Lys Arg Gln Arg Lys Asn Ala 
    210                 215                 220                 


Thr Gln Glu Ala Leu Arg Lys Gly Asp Asp Val Lys Phe Glu Glu Phe 
225                 230                 235                 240 


Val Ala Tyr Leu Ile Asp Pro His Thr Gln Arg Glu Glu Pro Phe Asn 
                245                 250                 255     


Glu His Trp Gln Thr Val Tyr Ser Leu Cys His Pro Cys His Ile His 
            260                 265                 270         


Tyr Asp Leu Val Gly Lys Tyr Glu Thr Leu Glu Glu Asp Ser Asn Tyr 
        275                 280                 285             


Val Leu Gln Leu Ala Gly Val Gly Ser Tyr Leu Lys Phe Pro Thr Tyr 
    290                 295                 300                 


Ala Lys Ser Thr Arg Thr Thr Asp Glu Met Thr Thr Glu Phe Phe Gln 
305                 310                 315                 320 


Asn Ile Ser Ser Glu His Gln Thr Gln Leu Tyr Glu Val Tyr Lys Leu 
                325                 330                 335     


Asp Phe Leu Met Phe Asn Tyr Ser Val Pro Ser Tyr Leu Lys Leu Glu 
            340                 345                 350         


<210>  526
<211>  72
<212>  PRT
<213>  Homo sapiens

<400>  526

Met Lys Pro Ala Leu Leu Glu Val Met Arg Met Asn Arg Ile Cys Arg 
1               5                   10                  15      


Met Val Leu Ala Thr Cys Leu Gly Ser Phe Ile Leu Val Ile Phe Tyr 
            20                  25                  30          


Phe Gln Ile Met Arg Arg Asn Pro Phe Gly Val Asp Ile Cys Cys Arg 
        35                  40                  45              


Lys Gly Ser Arg Ser Pro Leu Gln Glu Leu Tyr Asn Pro Ile Gln Val 
    50                  55                  60                  


Ser Phe Lys His Ser Val Ser Met 
65                  70          


<210>  527
<211>  77
<212>  PRT
<213>  Homo sapiens

<400>  527

Met Lys Pro Ala Leu Leu Glu Val Met Arg Met Asn Arg Ile Cys Arg 
1               5                   10                  15      


Met Val Leu Ala Thr Cys Leu Gly Ser Phe Ile Leu Val Ile Phe Tyr 
            20                  25                  30          


Phe Gln Ser Met Leu His Pro Val Met Arg Arg Asn Pro Phe Gly Val 
        35                  40                  45              


Asp Ile Cys Cys Arg Lys Gly Ser Arg Ser Pro Leu Gln Glu Leu Tyr 
    50                  55                  60                  


Asn Pro Ile Gln Val Ser Phe Lys His Ser Val Ser Met 
65                  70                  75          


<210>  528
<211>  347
<212>  PRT
<213>  Homo sapiens

<400>  528

Met Lys Pro Ala Leu Leu Glu Val Met Arg Met Asn Arg Ile Cys Arg 
1               5                   10                  15      


Met Val Leu Ala Thr Cys Leu Gly Ser Phe Ile Leu Val Ile Phe Tyr 
            20                  25                  30          


Phe Gln Ile Met Arg Arg Asn Pro Phe Gly Val Asp Ile Cys Cys Arg 
        35                  40                  45              


Lys Gly Ser Arg Ser Pro Leu Gln Glu Leu Tyr Asn Pro Ile Gln Leu 
    50                  55                  60                  


Glu Leu Ser Asn Thr Ala Val Leu His Gln Met Arg Arg Asp Gln Val 
65                  70                  75                  80  


Thr Asp Thr Cys Arg Ala Asn Ser Ala Thr Ser Arg Lys Arg Arg Val 
                85                  90                  95      


Leu Thr Pro Asn Asp Leu Lys His Leu Val Val Asp Glu Asp His Glu 
            100                 105                 110         


Leu Ile Tyr Cys Tyr Val Pro Lys Val Ala Cys Thr Asn Trp Lys Arg 
        115                 120                 125             


Leu Met Met Val Leu Thr Gly Arg Gly Lys Tyr Ser Asp Pro Met Glu 
    130                 135                 140                 


Ile Pro Ala Asn Glu Ala His Val Ser Ala Asn Leu Lys Thr Leu Asn 
145                 150                 155                 160 


Gln Tyr Ser Ile Pro Glu Ile Asn His Arg Leu Lys Ser Tyr Met Lys 
                165                 170                 175     


Phe Leu Phe Val Arg Glu Pro Phe Glu Arg Leu Val Ser Ala Tyr Arg 
            180                 185                 190         


Asn Lys Phe Thr Gln Lys Tyr Asn Ile Ser Phe His Lys Arg Tyr Gly 
        195                 200                 205             


Thr Lys Ile Ile Lys Arg Gln Arg Lys Asn Ala Thr Gln Glu Ala Leu 
    210                 215                 220                 


Arg Lys Gly Asp Asp Val Lys Phe Glu Glu Phe Val Ala Tyr Leu Ile 
225                 230                 235                 240 


Asp Pro His Thr Gln Arg Glu Glu Pro Phe Asn Glu His Trp Gln Thr 
                245                 250                 255     


Val Tyr Ser Leu Cys His Pro Cys His Ile His Tyr Asp Leu Val Gly 
            260                 265                 270         


Lys Tyr Glu Thr Leu Glu Glu Asp Ser Asn Tyr Val Leu Gln Leu Ala 
        275                 280                 285             


Gly Val Gly Ser Tyr Leu Lys Phe Pro Thr Tyr Ala Lys Ser Thr Arg 
    290                 295                 300                 


Thr Thr Asp Glu Met Thr Thr Glu Phe Phe Gln Asn Ile Ser Ser Glu 
305                 310                 315                 320 


His Gln Thr Gln Leu Tyr Glu Val Tyr Lys Leu Asp Phe Leu Met Phe 
                325                 330                 335     


Asn Tyr Ser Val Pro Ser Tyr Leu Lys Leu Glu 
            340                 345         


<210>  529
<211>  775
<212>  PRT
<213>  Homo sapiens

<400>  529

Met Glu Pro Pro Tyr Ser Leu Thr Ala His Tyr Asp Glu Phe Gln Glu 
1               5                   10                  15      


Val Lys Tyr Val Ser Arg Cys Gly Ala Gly Gly Ala Arg Gly Ala Ser 
            20                  25                  30          


Leu Pro Pro Gly Phe Pro Leu Gly Ala Ala Arg Ser Ala Thr Gly Ala 
        35                  40                  45              


Arg Ser Gly Leu Pro Arg Trp Asn Arg Arg Glu Val Cys Leu Leu Ser 
    50                  55                  60                  


Gly Leu Val Phe Ala Ala Gly Leu Cys Ala Ile Leu Ala Ala Met Leu 
65                  70                  75                  80  


Ala Leu Lys Tyr Leu Gly Pro Val Ala Ala Gly Gly Gly Ala Cys Pro 
                85                  90                  95      


Glu Gly Cys Pro Glu Arg Lys Ala Phe Ala Arg Ala Ala Arg Phe Leu 
            100                 105                 110         


Ala Ala Asn Leu Asp Ala Ser Ile Asp Pro Cys Gln Asp Phe Tyr Ser 
        115                 120                 125             


Phe Ala Cys Gly Gly Trp Leu Arg Arg His Ala Ile Pro Asp Asp Lys 
    130                 135                 140                 


Leu Thr Tyr Gly Thr Ile Ala Ala Ile Gly Glu Gln Asn Glu Glu Arg 
145                 150                 155                 160 


Leu Arg Arg Leu Leu Ala Arg Pro Gly Gly Gly Pro Gly Gly Ala Ala 
                165                 170                 175     


Gln Arg Lys Val Arg Ala Phe Phe Arg Ser Cys Leu Asp Met Arg Glu 
            180                 185                 190         


Ile Glu Arg Leu Gly Pro Arg Pro Met Leu Glu Val Ile Glu Asp Cys 
        195                 200                 205             


Gly Gly Trp Asp Leu Gly Gly Ala Glu Glu Arg Pro Gly Val Ala Ala 
    210                 215                 220                 


Arg Trp Asp Leu Asn Arg Leu Leu Tyr Lys Ala Gln Gly Val Tyr Ser 
225                 230                 235                 240 


Ala Ala Ala Leu Phe Ser Leu Thr Val Ser Leu Asp Asp Arg Asn Ser 
                245                 250                 255     


Ser Arg Tyr Val Ile Arg Ile Asp Gln Asp Gly Leu Thr Leu Pro Glu 
            260                 265                 270         


Arg Thr Leu Tyr Leu Ala Gln Asp Glu Asp Ser Glu Lys Ile Leu Ala 
        275                 280                 285             


Ala Tyr Arg Val Phe Met Glu Arg Val Leu Ser Leu Leu Gly Ala Asp 
    290                 295                 300                 


Ala Val Glu Gln Lys Ala Gln Glu Ile Leu Gln Val Glu Gln Gln Leu 
305                 310                 315                 320 


Ala Asn Ile Thr Val Ser Glu His Asp Asp Leu Arg Arg Asp Val Ser 
                325                 330                 335     


Ser Met Tyr Asn Lys Val Thr Leu Gly Gln Leu Gln Lys Ile Thr Pro 
            340                 345                 350         


His Leu Arg Trp Lys Trp Leu Leu Asp Gln Ile Phe Gln Glu Asp Phe 
        355                 360                 365             


Ser Glu Glu Glu Glu Val Val Leu Leu Ala Thr Asp Tyr Met Gln Gln 
    370                 375                 380                 


Val Ser Gln Leu Ile Arg Ser Thr Pro His Arg Val Leu His Asn Tyr 
385                 390                 395                 400 


Leu Val Trp Arg Val Val Val Val Leu Ser Glu His Leu Ser Pro Pro 
                405                 410                 415     


Phe Arg Glu Ala Leu His Glu Leu Ala Gln Glu Met Glu Gly Ser Asp 
            420                 425                 430         


Lys Pro Gln Glu Leu Ala Arg Val Cys Leu Gly Gln Ala Asn Arg His 
        435                 440                 445             


Phe Gly Met Ala Leu Gly Ala Leu Phe Val His Glu His Phe Ser Ala 
    450                 455                 460                 


Ala Ser Lys Ala Lys Val Gln Gln Leu Val Glu Asp Ile Lys Tyr Ile 
465                 470                 475                 480 


Leu Gly Gln Arg Leu Glu Glu Leu Asp Trp Met Asp Ala Glu Thr Arg 
                485                 490                 495     


Ala Ala Ala Arg Ala Lys Leu Gln Tyr Met Met Val Met Val Gly Tyr 
            500                 505                 510         


Pro Asp Phe Leu Leu Lys Pro Asp Ala Val Asp Lys Glu Tyr Glu Phe 
        515                 520                 525             


Glu Val His Glu Lys Thr Tyr Phe Lys Asn Ile Leu Asn Ser Ile Arg 
    530                 535                 540                 


Phe Ser Ile Gln Leu Ser Val Lys Lys Ile Arg Gln Glu Val Asp Lys 
545                 550                 555                 560 


Ser Thr Trp Leu Leu Pro Pro Gln Ala Leu Asn Ala Tyr Tyr Leu Pro 
                565                 570                 575     


Asn Lys Asn Gln Met Val Phe Pro Ala Gly Ile Leu Gln Pro Thr Leu 
            580                 585                 590         


Tyr Asp Pro Asp Phe Pro Gln Ser Leu Asn Tyr Gly Gly Ile Gly Thr 
        595                 600                 605             


Ile Ile Gly His Glu Leu Thr His Gly Tyr Asp Asp Trp Gly Gly Gln 
    610                 615                 620                 


Tyr Asp Arg Ser Gly Asn Leu Leu His Trp Trp Thr Glu Ala Ser Tyr 
625                 630                 635                 640 


Ser Arg Phe Leu Arg Lys Ala Glu Cys Ile Val Arg Leu Tyr Asp Asn 
                645                 650                 655     


Phe Thr Val Tyr Asn Gln Arg Val Asn Gly Lys His Thr Leu Gly Glu 
            660                 665                 670         


Asn Ile Ala Asp Met Gly Gly Leu Lys Leu Ala Tyr His Ala Tyr Gln 
        675                 680                 685             


Lys Trp Val Arg Glu His Gly Pro Glu His Pro Leu Pro Arg Leu Lys 
    690                 695                 700                 


Tyr Thr His Asp Gln Leu Phe Phe Ile Ala Phe Ala Gln Asn Trp Cys 
705                 710                 715                 720 


Ile Lys Arg Arg Ser Gln Ser Ile Tyr Leu Gln Val Leu Thr Asp Lys 
                725                 730                 735     


His Ala Pro Glu His Tyr Arg Val Leu Gly Ser Val Ser Gln Phe Glu 
            740                 745                 750         


Glu Phe Gly Arg Ala Phe His Cys Pro Lys Asp Ser Pro Met Asn Pro 
        755                 760                 765             


Ala His Lys Cys Ser Val Trp 
    770                 775 


<210>  530
<211>  773
<212>  PRT
<213>  Homo sapiens

<400>  530

Met Glu Pro Pro Tyr Ser Leu Thr Ala His Tyr Asp Glu Phe Gln Glu 
1               5                   10                  15      


Val Lys Tyr Val Ser Arg Cys Gly Ala Gly Gly Ala Arg Gly Ala Ser 
            20                  25                  30          


Leu Pro Pro Gly Phe Pro Leu Gly Ala Ala Arg Ser Ala Thr Gly Ala 
        35                  40                  45              


Arg Ser Gly Leu Pro Arg Trp Asn Arg Arg Glu Val Cys Leu Leu Ser 
    50                  55                  60                  


Gly Leu Val Phe Ala Ala Gly Leu Cys Ala Ile Leu Ala Ala Met Leu 
65                  70                  75                  80  


Ala Leu Lys Tyr Leu Gly Pro Val Ala Ala Gly Gly Gly Ala Cys Pro 
                85                  90                  95      


Glu Gly Cys Pro Glu Arg Lys Ala Phe Ala Arg Ala Ala Arg Phe Leu 
            100                 105                 110         


Ala Ala Asn Leu Asp Ala Ser Ile Asp Pro Cys Gln Asp Phe Tyr Ser 
        115                 120                 125             


Phe Ala Cys Gly Gly Trp Leu Arg Arg His Ala Ile Pro Asp Asp Lys 
    130                 135                 140                 


Leu Thr Tyr Gly Thr Ile Ala Ala Ile Gly Glu Gln Asn Glu Glu Arg 
145                 150                 155                 160 


Leu Arg Arg Leu Leu Ala Arg Pro Gly Gly Gly Pro Gly Gly Ala Ala 
                165                 170                 175     


Gln Arg Lys Val Arg Ala Phe Phe Arg Ser Cys Leu Asp Met Arg Glu 
            180                 185                 190         


Ile Glu Arg Leu Gly Pro Arg Pro Met Leu Glu Val Ile Glu Asp Cys 
        195                 200                 205             


Gly Gly Trp Asp Leu Gly Gly Ala Glu Glu Arg Pro Gly Val Ala Ala 
    210                 215                 220                 


Arg Trp Asp Leu Asn Arg Leu Leu Tyr Lys Ala Gln Gly Val Tyr Ser 
225                 230                 235                 240 


Ala Ala Ala Leu Phe Ser Leu Thr Val Ser Leu Asp Asp Arg Asn Ser 
                245                 250                 255     


Ser Arg Tyr Val Ile Arg Ile Asp Gln Asp Gly Leu Thr Leu Pro Glu 
            260                 265                 270         


Arg Thr Leu Tyr Leu Ala Gln Asp Glu Asp Ser Glu Lys Ile Leu Ala 
        275                 280                 285             


Ala Tyr Arg Val Phe Met Glu Arg Val Leu Ser Leu Leu Gly Ala Asp 
    290                 295                 300                 


Ala Val Glu Gln Lys Ala Gln Glu Ile Leu Gln Val Glu Gln Gln Leu 
305                 310                 315                 320 


Ala Asn Ile Thr Val Ser Glu His Asp Asp Leu Arg Arg Asp Val Ser 
                325                 330                 335     


Ser Met Tyr Asn Lys Val Thr Leu Gly Gln Leu Gln Lys Ile Thr Pro 
            340                 345                 350         


His Leu Arg Trp Lys Trp Leu Leu Asp Gln Ile Phe Gln Glu Asp Phe 
        355                 360                 365             


Ser Glu Glu Glu Glu Val Val Leu Leu Ala Thr Asp Tyr Met Gln Gln 
    370                 375                 380                 


Val Ser Gln Leu Ile Arg Ser Thr Pro His Arg Val Leu His Asn Tyr 
385                 390                 395                 400 


Leu Val Trp Arg Val Val Val Val Leu Ser Glu His Leu Ser Pro Pro 
                405                 410                 415     


Phe Arg Glu Ala Leu His Glu Leu Ala Gln Glu Met Glu Gly Ser Asp 
            420                 425                 430         


Lys Pro Gln Glu Leu Ala Arg Val Cys Leu Gly Gln Ala Asn Arg His 
        435                 440                 445             


Phe Gly Met Ala Leu Gly Ala Leu Phe Val His Glu His Phe Ser Ala 
    450                 455                 460                 


Ala Ser Lys Ala Lys Val Gln Gln Leu Val Glu Asp Ile Lys Tyr Ile 
465                 470                 475                 480 


Leu Gly Gln Arg Leu Glu Glu Leu Asp Trp Met Asp Ala Glu Thr Arg 
                485                 490                 495     


Ala Ala Ala Arg Ala Lys Leu Gln Tyr Met Met Val Met Val Gly Tyr 
            500                 505                 510         


Pro Asp Phe Leu Leu Lys Pro Asp Ala Val Asp Lys Glu Tyr Glu Phe 
        515                 520                 525             


Glu Val His Glu Lys Thr Tyr Phe Lys Asn Ile Leu Asn Ser Ile Arg 
    530                 535                 540                 


Phe Ser Ile Gln Leu Ser Val Lys Lys Ile Arg Gln Glu Val Asp Lys 
545                 550                 555                 560 


Trp Leu Leu Pro Pro Gln Ala Leu Asn Ala Tyr Tyr Leu Pro Asn Lys 
                565                 570                 575     


Asn Gln Met Val Phe Pro Ala Gly Ile Leu Gln Pro Thr Leu Tyr Asp 
            580                 585                 590         


Pro Asp Phe Pro Gln Ser Leu Asn Tyr Gly Gly Ile Gly Thr Ile Ile 
        595                 600                 605             


Gly His Glu Leu Thr His Gly Tyr Asp Asp Trp Gly Gly Gln Tyr Asp 
    610                 615                 620                 


Arg Ser Gly Asn Leu Leu His Trp Trp Thr Glu Ala Ser Tyr Ser Arg 
625                 630                 635                 640 


Phe Leu Arg Lys Ala Glu Cys Ile Val Arg Leu Tyr Asp Asn Phe Thr 
                645                 650                 655     


Val Tyr Asn Gln Arg Val Asn Gly Lys His Thr Leu Gly Glu Asn Ile 
            660                 665                 670         


Ala Asp Met Gly Gly Leu Lys Leu Ala Tyr His Ala Tyr Gln Lys Trp 
        675                 680                 685             


Val Arg Glu His Gly Pro Glu His Pro Leu Pro Arg Leu Lys Tyr Thr 
    690                 695                 700                 


His Asp Gln Leu Phe Phe Ile Ala Phe Ala Gln Asn Trp Cys Ile Lys 
705                 710                 715                 720 


Arg Arg Ser Gln Ser Ile Tyr Leu Gln Val Leu Thr Asp Lys His Ala 
                725                 730                 735     


Pro Glu His Tyr Arg Val Leu Gly Ser Val Ser Gln Phe Glu Glu Phe 
            740                 745                 750         


Gly Arg Ala Phe His Cys Pro Lys Asp Ser Pro Met Asn Pro Ala His 
        755                 760                 765             


Lys Cys Ser Val Trp 
    770             


<210>  531
<211>  233
<212>  PRT
<213>  Homo sapiens

<400>  531

Met Ser Gln Ser Asn Arg Glu Leu Val Val Asp Phe Leu Ser Tyr Lys 
1               5                   10                  15      


Leu Ser Gln Lys Gly Tyr Ser Trp Ser Gln Phe Ser Asp Val Glu Glu 
            20                  25                  30          


Asn Arg Thr Glu Ala Pro Glu Gly Thr Glu Ser Glu Met Glu Thr Pro 
        35                  40                  45              


Ser Ala Ile Asn Gly Asn Pro Ser Trp His Leu Ala Asp Ser Pro Ala 
    50                  55                  60                  


Val Asn Gly Ala Thr Gly His Ser Ser Ser Leu Asp Ala Arg Glu Val 
65                  70                  75                  80  


Ile Pro Met Ala Ala Val Lys Gln Ala Leu Arg Glu Ala Gly Asp Glu 
                85                  90                  95      


Phe Glu Leu Arg Tyr Arg Arg Ala Phe Ser Asp Leu Thr Ser Gln Leu 
            100                 105                 110         


His Ile Thr Pro Gly Thr Ala Tyr Gln Ser Phe Glu Gln Val Val Asn 
        115                 120                 125             


Glu Leu Phe Arg Asp Gly Val Asn Trp Gly Arg Ile Val Ala Phe Phe 
    130                 135                 140                 


Ser Phe Gly Gly Ala Leu Cys Val Glu Ser Val Asp Lys Glu Met Gln 
145                 150                 155                 160 


Val Leu Val Ser Arg Ile Ala Ala Trp Met Ala Thr Tyr Leu Asn Asp 
                165                 170                 175     


His Leu Glu Pro Trp Ile Gln Glu Asn Gly Gly Trp Asp Thr Phe Val 
            180                 185                 190         


Glu Leu Tyr Gly Asn Asn Ala Ala Ala Glu Ser Arg Lys Gly Gln Glu 
        195                 200                 205             


Arg Phe Asn Arg Trp Phe Leu Thr Gly Met Thr Val Ala Gly Val Val 
    210                 215                 220                 


Leu Leu Gly Ser Leu Phe Ser Arg Lys 
225                 230             


<210>  532
<211>  170
<212>  PRT
<213>  Homo sapiens

<400>  532

Met Ser Gln Ser Asn Arg Glu Leu Val Val Asp Phe Leu Ser Tyr Lys 
1               5                   10                  15      


Leu Ser Gln Lys Gly Tyr Ser Trp Ser Gln Phe Ser Asp Val Glu Glu 
            20                  25                  30          


Asn Arg Thr Glu Ala Pro Glu Gly Thr Glu Ser Glu Met Glu Thr Pro 
        35                  40                  45              


Ser Ala Ile Asn Gly Asn Pro Ser Trp His Leu Ala Asp Ser Pro Ala 
    50                  55                  60                  


Val Asn Gly Ala Thr Gly His Ser Ser Ser Leu Asp Ala Arg Glu Val 
65                  70                  75                  80  


Ile Pro Met Ala Ala Val Lys Gln Ala Leu Arg Glu Ala Gly Asp Glu 
                85                  90                  95      


Phe Glu Leu Arg Tyr Arg Arg Ala Phe Ser Asp Leu Thr Ser Gln Leu 
            100                 105                 110         


His Ile Thr Pro Gly Thr Ala Tyr Gln Ser Phe Glu Gln Asp Thr Phe 
        115                 120                 125             


Val Glu Leu Tyr Gly Asn Asn Ala Ala Ala Glu Ser Arg Lys Gly Gln 
    130                 135                 140                 


Glu Arg Phe Asn Arg Trp Phe Leu Thr Gly Met Thr Val Ala Gly Val 
145                 150                 155                 160 


Val Leu Leu Gly Ser Leu Phe Ser Arg Lys 
                165                 170 


<210>  533
<211>  233
<212>  PRT
<213>  Homo sapiens

<400>  533

Met Ser Gln Ser Asn Arg Glu Leu Val Val Asp Phe Leu Ser Tyr Lys 
1               5                   10                  15      


Leu Ser Gln Lys Gly Tyr Ser Trp Ser Gln Phe Ser Asp Val Glu Glu 
            20                  25                  30          


Asn Arg Thr Glu Ala Pro Glu Gly Thr Glu Ser Glu Met Glu Thr Pro 
        35                  40                  45              


Ser Ala Ile Asn Gly Asn Pro Ser Trp His Leu Ala Asp Ser Pro Ala 
    50                  55                  60                  


Val Asn Gly Ala Thr Gly His Ser Ser Ser Leu Asp Ala Arg Glu Val 
65                  70                  75                  80  


Ile Pro Met Ala Ala Val Lys Gln Ala Leu Arg Glu Ala Gly Asp Glu 
                85                  90                  95      


Phe Glu Leu Arg Tyr Arg Arg Ala Phe Ser Asp Leu Thr Ser Gln Leu 
            100                 105                 110         


His Ile Thr Pro Gly Thr Ala Tyr Gln Ser Phe Glu Gln Val Val Asn 
        115                 120                 125             


Glu Leu Phe Arg Asp Gly Val Asn Trp Gly Arg Ile Val Ala Phe Phe 
    130                 135                 140                 


Ser Phe Gly Gly Ala Leu Cys Val Glu Ser Val Asp Lys Glu Met Gln 
145                 150                 155                 160 


Val Leu Val Ser Arg Ile Ala Ala Trp Met Ala Thr Tyr Leu Asn Asp 
                165                 170                 175     


His Leu Glu Pro Trp Ile Gln Glu Asn Gly Gly Trp Asp Thr Phe Val 
            180                 185                 190         


Glu Leu Tyr Gly Asn Asn Ala Ala Ala Glu Ser Arg Lys Gly Gln Glu 
        195                 200                 205             


Arg Phe Asn Arg Trp Phe Leu Thr Gly Met Thr Val Ala Gly Val Val 
    210                 215                 220                 


Leu Leu Gly Ser Leu Phe Ser Arg Lys 
225                 230             


<210>  534
<211>  813
<212>  PRT
<213>  Homo sapiens

<400>  534

Met Ser Leu Leu Gly Asp Pro Leu Gln Ala Leu Pro Pro Ser Ala Ala 
1               5                   10                  15      


Pro Thr Gly Pro Leu Leu Ala Pro Pro Ala Gly Ala Thr Leu Asn Arg 
            20                  25                  30          


Leu Arg Glu Pro Leu Leu Arg Arg Leu Ser Glu Leu Leu Asp Gln Ala 
        35                  40                  45              


Pro Glu Gly Arg Gly Trp Arg Arg Leu Ala Glu Leu Ala Gly Ser Arg 
    50                  55                  60                  


Gly Arg Leu Arg Leu Ser Cys Leu Asp Leu Glu Gln Cys Ser Leu Lys 
65                  70                  75                  80  


Val Leu Glu Pro Glu Gly Ser Pro Ser Leu Cys Leu Leu Lys Leu Met 
                85                  90                  95      


Gly Glu Lys Gly Cys Thr Val Thr Glu Leu Ser Asp Phe Leu Gln Ala 
            100                 105                 110         


Met Glu His Thr Glu Val Leu Gln Leu Leu Ser Pro Pro Gly Ile Lys 
        115                 120                 125             


Ile Thr Val Asn Pro Glu Ser Lys Ala Val Leu Ala Gly Gln Phe Val 
    130                 135                 140                 


Lys Leu Cys Cys Arg Ala Thr Gly His Pro Phe Val Gln Tyr Gln Trp 
145                 150                 155                 160 


Phe Lys Met Asn Lys Glu Ile Pro Asn Gly Asn Thr Ser Glu Leu Ile 
                165                 170                 175     


Phe Asn Ala Val His Val Lys Asp Ala Gly Phe Tyr Val Cys Arg Val 
            180                 185                 190         


Asn Asn Asn Phe Thr Phe Glu Phe Ser Gln Trp Ser Gln Leu Asp Val 
        195                 200                 205             


Cys Asp Ile Pro Glu Ser Phe Gln Arg Ser Val Asp Gly Val Ser Glu 
    210                 215                 220                 


Ser Lys Leu Gln Ile Cys Val Glu Pro Thr Ser Gln Lys Leu Met Pro 
225                 230                 235                 240 


Gly Ser Thr Leu Val Leu Gln Cys Val Ala Val Gly Ser Pro Ile Pro 
                245                 250                 255     


His Tyr Gln Trp Phe Lys Asn Glu Leu Pro Leu Thr His Glu Thr Lys 
            260                 265                 270         


Lys Leu Tyr Met Val Pro Tyr Val Asp Leu Glu His Gln Gly Thr Tyr 
        275                 280                 285             


Trp Cys His Val Tyr Asn Asp Arg Asp Ser Gln Asp Ser Lys Lys Val 
    290                 295                 300                 


Glu Ile Ile Ile Asp Glu Leu Asn Asn Leu Gly His Pro Asp Asn Lys 
305                 310                 315                 320 


Glu Gln Thr Thr Asp Gln Pro Leu Ala Lys Asp Lys Val Ala Leu Leu 
                325                 330                 335     


Ile Gly Asn Met Asn Tyr Arg Glu His Pro Lys Leu Lys Ala Pro Leu 
            340                 345                 350         


Val Asp Val Tyr Glu Leu Thr Asn Leu Leu Arg Gln Leu Asp Phe Lys 
        355                 360                 365             


Val Val Ser Leu Leu Asp Leu Thr Glu Tyr Glu Met Arg Asn Ala Val 
    370                 375                 380                 


Asp Glu Phe Leu Leu Leu Leu Asp Lys Gly Val Tyr Gly Leu Leu Tyr 
385                 390                 395                 400 


Tyr Ala Gly His Gly Tyr Glu Asn Phe Gly Asn Ser Phe Met Val Pro 
                405                 410                 415     


Val Asp Ala Pro Asn Pro Tyr Arg Ser Glu Asn Cys Leu Cys Val Gln 
            420                 425                 430         


Asn Ile Leu Lys Leu Met Gln Glu Lys Glu Thr Gly Leu Asn Val Phe 
        435                 440                 445             


Leu Leu Asp Met Cys Arg Lys Arg Asn Asp Tyr Asp Asp Thr Ile Pro 
    450                 455                 460                 


Ile Leu Asp Ala Leu Lys Val Thr Ala Asn Ile Val Phe Gly Tyr Ala 
465                 470                 475                 480 


Thr Cys Gln Gly Ala Glu Ala Phe Glu Ile Gln His Ser Gly Leu Ala 
                485                 490                 495     


Asn Gly Ile Phe Met Lys Phe Leu Lys Asp Arg Leu Leu Glu Asp Lys 
            500                 505                 510         


Lys Ile Thr Val Leu Leu Asp Glu Val Ala Glu Asp Met Gly Lys Cys 
        515                 520                 525             


His Leu Thr Lys Gly Lys Gln Ala Leu Glu Ile Arg Ser Ser Leu Ser 
    530                 535                 540                 


Glu Lys Arg Ala Leu Thr Asp Pro Ile Gln Gly Thr Glu Tyr Ser Ala 
545                 550                 555                 560 


Glu Ser Leu Val Arg Asn Leu Gln Trp Ala Lys Ala His Glu Leu Pro 
                565                 570                 575     


Glu Ser Met Cys Leu Lys Phe Asp Cys Gly Val Gln Ile Gln Leu Gly 
            580                 585                 590         


Phe Ala Ala Glu Phe Ser Asn Val Met Ile Ile Tyr Thr Ser Ile Val 
        595                 600                 605             


Tyr Lys Pro Pro Glu Ile Ile Met Cys Asp Ala Tyr Val Thr Asp Phe 
    610                 615                 620                 


Pro Leu Asp Leu Asp Ile Asp Pro Lys Asp Ala Asn Lys Gly Thr Pro 
625                 630                 635                 640 


Glu Glu Thr Gly Ser Tyr Leu Val Ser Lys Asp Leu Pro Lys His Cys 
                645                 650                 655     


Leu Tyr Thr Arg Leu Ser Ser Leu Gln Lys Leu Lys Glu His Leu Val 
            660                 665                 670         


Phe Thr Val Cys Leu Ser Tyr Gln Tyr Ser Gly Leu Glu Asp Thr Val 
        675                 680                 685             


Glu Asp Lys Gln Glu Val Asn Val Gly Lys Pro Leu Ile Ala Lys Leu 
    690                 695                 700                 


Asp Met His Arg Gly Leu Gly Arg Lys Thr Cys Phe Gln Thr Cys Leu 
705                 710                 715                 720 


Met Ser Asn Gly Pro Tyr Gln Ser Ser Ala Ala Thr Ser Gly Gly Ala 
                725                 730                 735     


Gly His Tyr His Ser Leu Gln Asp Pro Phe His Gly Val Tyr His Ser 
            740                 745                 750         


His Pro Gly Asn Pro Ser Asn Val Thr Pro Ala Asp Ser Cys His Cys 
        755                 760                 765             


Ser Arg Thr Pro Asp Ala Phe Ile Ser Ser Phe Ala His His Ala Ser 
    770                 775                 780                 


Cys His Phe Ser Arg Ser Asn Val Pro Val Glu Thr Thr Asp Glu Ile 
785                 790                 795                 800 


Pro Phe Ser Phe Ser Asp Arg Leu Arg Ile Ser Glu Lys 
                805                 810             


<210>  535
<211>  824
<212>  PRT
<213>  Homo sapiens

<400>  535

Met Ser Leu Leu Gly Asp Pro Leu Gln Ala Leu Pro Pro Ser Ala Ala 
1               5                   10                  15      


Pro Thr Gly Pro Leu Leu Ala Pro Pro Ala Gly Ala Thr Leu Asn Arg 
            20                  25                  30          


Leu Arg Glu Pro Leu Leu Arg Arg Leu Ser Glu Leu Leu Asp Gln Ala 
        35                  40                  45              


Pro Glu Gly Arg Gly Trp Arg Arg Leu Ala Glu Leu Ala Gly Ser Arg 
    50                  55                  60                  


Gly Arg Leu Arg Leu Ser Cys Leu Asp Leu Glu Gln Cys Ser Leu Lys 
65                  70                  75                  80  


Val Leu Glu Pro Glu Gly Ser Pro Ser Leu Cys Leu Leu Lys Leu Met 
                85                  90                  95      


Gly Glu Lys Gly Cys Thr Val Thr Glu Leu Ser Asp Phe Leu Gln Ala 
            100                 105                 110         


Met Glu His Thr Glu Val Leu Gln Leu Leu Ser Pro Pro Gly Ile Lys 
        115                 120                 125             


Ile Thr Val Asn Pro Glu Ser Lys Ala Val Leu Ala Gly Gln Phe Val 
    130                 135                 140                 


Lys Leu Cys Cys Arg Ala Thr Gly His Pro Phe Val Gln Tyr Gln Trp 
145                 150                 155                 160 


Phe Lys Met Asn Lys Glu Ile Pro Asn Gly Asn Thr Ser Glu Leu Ile 
                165                 170                 175     


Phe Asn Ala Val His Val Lys Asp Ala Gly Phe Tyr Val Cys Arg Val 
            180                 185                 190         


Asn Asn Asn Phe Thr Phe Glu Phe Ser Gln Trp Ser Gln Leu Asp Val 
        195                 200                 205             


Cys Asp Ile Pro Glu Ser Phe Gln Arg Ser Val Asp Gly Val Ser Glu 
    210                 215                 220                 


Ser Lys Leu Gln Ile Cys Val Glu Pro Thr Ser Gln Lys Leu Met Pro 
225                 230                 235                 240 


Gly Ser Thr Leu Val Leu Gln Cys Val Ala Val Gly Ser Pro Ile Pro 
                245                 250                 255     


His Tyr Gln Trp Phe Lys Asn Glu Leu Pro Leu Thr His Glu Thr Lys 
            260                 265                 270         


Lys Leu Tyr Met Val Pro Tyr Val Asp Leu Glu His Gln Gly Thr Tyr 
        275                 280                 285             


Trp Cys His Val Tyr Asn Asp Arg Asp Ser Gln Asp Ser Lys Lys Val 
    290                 295                 300                 


Glu Ile Ile Ile Gly Arg Thr Asp Glu Ala Val Glu Cys Thr Glu Asp 
305                 310                 315                 320 


Glu Leu Asn Asn Leu Gly His Pro Asp Asn Lys Glu Gln Thr Thr Asp 
                325                 330                 335     


Gln Pro Leu Ala Lys Asp Lys Val Ala Leu Leu Ile Gly Asn Met Asn 
            340                 345                 350         


Tyr Arg Glu His Pro Lys Leu Lys Ala Pro Leu Val Asp Val Tyr Glu 
        355                 360                 365             


Leu Thr Asn Leu Leu Arg Gln Leu Asp Phe Lys Val Val Ser Leu Leu 
    370                 375                 380                 


Asp Leu Thr Glu Tyr Glu Met Arg Asn Ala Val Asp Glu Phe Leu Leu 
385                 390                 395                 400 


Leu Leu Asp Lys Gly Val Tyr Gly Leu Leu Tyr Tyr Ala Gly His Gly 
                405                 410                 415     


Tyr Glu Asn Phe Gly Asn Ser Phe Met Val Pro Val Asp Ala Pro Asn 
            420                 425                 430         


Pro Tyr Arg Ser Glu Asn Cys Leu Cys Val Gln Asn Ile Leu Lys Leu 
        435                 440                 445             


Met Gln Glu Lys Glu Thr Gly Leu Asn Val Phe Leu Leu Asp Met Cys 
    450                 455                 460                 


Arg Lys Arg Asn Asp Tyr Asp Asp Thr Ile Pro Ile Leu Asp Ala Leu 
465                 470                 475                 480 


Lys Val Thr Ala Asn Ile Val Phe Gly Tyr Ala Thr Cys Gln Gly Ala 
                485                 490                 495     


Glu Ala Phe Glu Ile Gln His Ser Gly Leu Ala Asn Gly Ile Phe Met 
            500                 505                 510         


Lys Phe Leu Lys Asp Arg Leu Leu Glu Asp Lys Lys Ile Thr Val Leu 
        515                 520                 525             


Leu Asp Glu Val Ala Glu Asp Met Gly Lys Cys His Leu Thr Lys Gly 
    530                 535                 540                 


Lys Gln Ala Leu Glu Ile Arg Ser Ser Leu Ser Glu Lys Arg Ala Leu 
545                 550                 555                 560 


Thr Asp Pro Ile Gln Gly Thr Glu Tyr Ser Ala Glu Ser Leu Val Arg 
                565                 570                 575     


Asn Leu Gln Trp Ala Lys Ala His Glu Leu Pro Glu Ser Met Cys Leu 
            580                 585                 590         


Lys Phe Asp Cys Gly Val Gln Ile Gln Leu Gly Phe Ala Ala Glu Phe 
        595                 600                 605             


Ser Asn Val Met Ile Ile Tyr Thr Ser Ile Val Tyr Lys Pro Pro Glu 
    610                 615                 620                 


Ile Ile Met Cys Asp Ala Tyr Val Thr Asp Phe Pro Leu Asp Leu Asp 
625                 630                 635                 640 


Ile Asp Pro Lys Asp Ala Asn Lys Gly Thr Pro Glu Glu Thr Gly Ser 
                645                 650                 655     


Tyr Leu Val Ser Lys Asp Leu Pro Lys His Cys Leu Tyr Thr Arg Leu 
            660                 665                 670         


Ser Ser Leu Gln Lys Leu Lys Glu His Leu Val Phe Thr Val Cys Leu 
        675                 680                 685             


Ser Tyr Gln Tyr Ser Gly Leu Glu Asp Thr Val Glu Asp Lys Gln Glu 
    690                 695                 700                 


Val Asn Val Gly Lys Pro Leu Ile Ala Lys Leu Asp Met His Arg Gly 
705                 710                 715                 720 


Leu Gly Arg Lys Thr Cys Phe Gln Thr Cys Leu Met Ser Asn Gly Pro 
                725                 730                 735     


Tyr Gln Ser Ser Ala Ala Thr Ser Gly Gly Ala Gly His Tyr His Ser 
            740                 745                 750         


Leu Gln Asp Pro Phe His Gly Val Tyr His Ser His Pro Gly Asn Pro 
        755                 760                 765             


Ser Asn Val Thr Pro Ala Asp Ser Cys His Cys Ser Arg Thr Pro Asp 
    770                 775                 780                 


Ala Phe Ile Ser Ser Phe Ala His His Ala Ser Cys His Phe Ser Arg 
785                 790                 795                 800 


Ser Asn Val Pro Val Glu Thr Thr Asp Glu Ile Pro Phe Ser Phe Ser 
                805                 810                 815     


Asp Arg Leu Arg Ile Ser Glu Lys 
            820                 


<210>  536
<211>  119
<212>  PRT
<213>  Homo sapiens

<400>  536

Met Gly Glu Lys Gly Cys Thr Val Thr Glu Leu Ser Asp Phe Leu Gln 
1               5                   10                  15      


Ala Met Glu His Thr Glu Val Leu Gln Leu Leu Ser Pro Pro Gly Ile 
            20                  25                  30          


Lys Ile Thr Val Asn Pro Glu Ser Lys Ala Val Leu Ala Gly Gln Phe 
        35                  40                  45              


Val Lys Leu Cys Cys Arg Ala Thr Gly His Pro Phe Val Gln Tyr Gln 
    50                  55                  60                  


Trp Phe Lys Met Asn Lys Glu Ile Pro Asn Gly Asn Thr Ser Glu Leu 
65                  70                  75                  80  


Ile Phe Asn Ala Val His Val Lys Asp Ala Gly Phe Tyr Val Cys Arg 
                85                  90                  95      


Val Asn Asn Asn Phe Thr Phe Glu Phe Ser Gln Trp Ser Gln Leu Asp 
            100                 105                 110         


Val Cys Asp Ile Pro Glu Ser 
        115                 


<210>  537
<211>  506
<212>  PRT
<213>  Homo sapiens

<400>  537

Met Ala Gly Glu Val Ser Ala Ala Thr Gly Arg Phe Ser Leu Glu Arg 
1               5                   10                  15      


Leu Gly Leu Pro Gly Leu Ala Leu Ala Ala Ala Leu Leu Leu Leu Ala 
            20                  25                  30          


Leu Cys Leu Leu Val Arg Arg Thr Arg Arg Pro Gly Glu Pro Pro Leu 
        35                  40                  45              


Ile Lys Gly Trp Leu Pro Tyr Leu Gly Val Val Leu Asn Leu Arg Lys 
    50                  55                  60                  


Asp Pro Leu Arg Phe Met Lys Thr Leu Gln Lys Gln His Gly Asp Thr 
65                  70                  75                  80  


Phe Thr Val Leu Leu Gly Gly Lys Tyr Ile Thr Phe Ile Leu Asp Pro 
                85                  90                  95      


Phe Gln Tyr Gln Leu Val Ile Lys Asn His Lys Gln Leu Ser Phe Arg 
            100                 105                 110         


Val Phe Ser Asn Lys Leu Leu Glu Lys Ala Phe Ser Ile Ser Gln Leu 
        115                 120                 125             


Gln Lys Asn His Asp Met Asn Asp Glu Leu His Leu Cys Tyr Gln Phe 
    130                 135                 140                 


Leu Gln Gly Lys Ser Leu Asp Ile Leu Leu Glu Ser Met Met Gln Asn 
145                 150                 155                 160 


Leu Lys Gln Val Phe Glu Pro Gln Leu Leu Lys Thr Thr Ser Trp Asp 
                165                 170                 175     


Thr Ala Glu Leu Tyr Pro Phe Cys Ser Ser Ile Ile Phe Glu Ile Thr 
            180                 185                 190         


Phe Thr Thr Ile Tyr Gly Lys Val Ile Val Cys Asp Asn Asn Lys Phe 
        195                 200                 205             


Ile Ser Glu Leu Arg Asp Asp Phe Leu Lys Phe Asp Asp Lys Phe Ala 
    210                 215                 220                 


Tyr Leu Val Ser Asn Ile Pro Ile Glu Leu Leu Gly Asn Val Lys Ser 
225                 230                 235                 240 


Ile Arg Glu Lys Ile Ile Lys Cys Phe Ser Ser Glu Lys Leu Ala Lys 
                245                 250                 255     


Met Gln Gly Trp Ser Glu Val Phe Gln Ser Arg Gln Asp Val Leu Glu 
            260                 265                 270         


Lys Tyr Tyr Val His Glu Asp Leu Glu Ile Gly Ala His His Leu Gly 
        275                 280                 285             


Phe Leu Trp Ala Ser Val Ala Asn Thr Ile Pro Thr Met Phe Trp Ala 
    290                 295                 300                 


Met Tyr Tyr Leu Leu Arg His Pro Glu Ala Met Ala Ala Val Arg Asp 
305                 310                 315                 320 


Glu Ile Asp Arg Leu Leu Gln Ser Thr Gly Gln Lys Lys Gly Ser Gly 
                325                 330                 335     


Phe Pro Ile His Leu Thr Arg Glu Gln Leu Asp Ser Leu Ile Cys Leu 
            340                 345                 350         


Glu Ser Ser Ile Phe Glu Ala Leu Arg Leu Ser Ser Tyr Ser Thr Thr 
        355                 360                 365             


Ile Arg Phe Val Glu Glu Asp Leu Thr Leu Ser Ser Glu Thr Gly Asp 
    370                 375                 380                 


Tyr Cys Val Arg Lys Gly Asp Leu Val Ala Ile Phe Pro Pro Val Leu 
385                 390                 395                 400 


His Gly Asp Pro Glu Ile Phe Glu Ala Pro Glu Glu Phe Arg Tyr Asp 
                405                 410                 415     


Arg Phe Ile Glu Asp Gly Lys Lys Lys Thr Thr Phe Phe Lys Arg Gly 
            420                 425                 430         


Lys Lys Leu Lys Cys Tyr Leu Met Pro Phe Gly Thr Gly Thr Ser Lys 
        435                 440                 445             


Cys Pro Gly Arg Phe Phe Ala Leu Met Glu Ile Lys Gln Leu Leu Val 
    450                 455                 460                 


Ile Leu Leu Thr Tyr Phe Asp Leu Glu Ile Ile Asp Asp Lys Pro Ile 
465                 470                 475                 480 


Gly Leu Asn Tyr Ser Arg Leu Leu Phe Gly Ile Gln Tyr Pro Asp Ser 
                485                 490                 495     


Asp Val Leu Phe Arg Tyr Lys Val Lys Ser 
            500                 505     


<210>  538
<211>  543
<212>  PRT
<213>  Homo sapiens

<400>  538

Met Leu Leu Arg Ser Lys Pro Ala Leu Pro Pro Pro Leu Met Leu Leu 
1               5                   10                  15      


Leu Leu Gly Pro Leu Gly Pro Leu Ser Pro Gly Ala Leu Pro Arg Pro 
            20                  25                  30          


Ala Gln Ala Gln Asp Val Val Asp Leu Asp Phe Phe Thr Gln Glu Pro 
        35                  40                  45              


Leu His Leu Val Ser Pro Ser Phe Leu Ser Val Thr Ile Asp Ala Asn 
    50                  55                  60                  


Leu Ala Thr Asp Pro Arg Phe Leu Ile Leu Leu Gly Ser Pro Lys Leu 
65                  70                  75                  80  


Arg Thr Leu Ala Arg Gly Leu Ser Pro Ala Tyr Leu Arg Phe Gly Gly 
                85                  90                  95      


Thr Lys Thr Asp Phe Leu Ile Phe Asp Pro Lys Lys Glu Ser Thr Phe 
            100                 105                 110         


Glu Glu Arg Ser Tyr Trp Gln Ser Gln Val Asn Gln Asp Ile Cys Lys 
        115                 120                 125             


Tyr Gly Ser Ile Pro Pro Asp Val Glu Glu Lys Leu Arg Leu Glu Trp 
    130                 135                 140                 


Pro Tyr Gln Glu Gln Leu Leu Leu Arg Glu His Tyr Gln Lys Lys Phe 
145                 150                 155                 160 


Lys Asn Ser Thr Tyr Ser Arg Ser Ser Val Asp Val Leu Tyr Thr Phe 
                165                 170                 175     


Ala Asn Cys Ser Gly Leu Asp Leu Ile Phe Gly Leu Asn Ala Leu Leu 
            180                 185                 190         


Arg Thr Ala Asp Leu Gln Trp Asn Ser Ser Asn Ala Gln Leu Leu Leu 
        195                 200                 205             


Asp Tyr Cys Ser Ser Lys Gly Tyr Asn Ile Ser Trp Glu Leu Gly Asn 
    210                 215                 220                 


Glu Pro Asn Ser Phe Leu Lys Lys Ala Asp Ile Phe Ile Asn Gly Ser 
225                 230                 235                 240 


Gln Leu Gly Glu Asp Phe Ile Gln Leu His Lys Leu Leu Arg Lys Ser 
                245                 250                 255     


Thr Phe Lys Asn Ala Lys Leu Tyr Gly Pro Asp Val Gly Gln Pro Arg 
            260                 265                 270         


Arg Lys Thr Ala Lys Met Leu Lys Ser Phe Leu Lys Ala Gly Gly Glu 
        275                 280                 285             


Val Ile Asp Ser Val Thr Trp His His Tyr Tyr Leu Asn Gly Arg Thr 
    290                 295                 300                 


Ala Thr Lys Glu Asp Phe Leu Asn Pro Asp Val Leu Asp Ile Phe Ile 
305                 310                 315                 320 


Ser Ser Val Gln Lys Val Phe Gln Val Val Glu Ser Thr Arg Pro Gly 
                325                 330                 335     


Lys Lys Val Trp Leu Gly Glu Thr Ser Ser Ala Tyr Gly Gly Gly Ala 
            340                 345                 350         


Pro Leu Leu Ser Asp Thr Phe Ala Ala Gly Phe Met Trp Leu Asp Lys 
        355                 360                 365             


Leu Gly Leu Ser Ala Arg Met Gly Ile Glu Val Val Met Arg Gln Val 
    370                 375                 380                 


Phe Phe Gly Ala Gly Asn Tyr His Leu Val Asp Glu Asn Phe Asp Pro 
385                 390                 395                 400 


Leu Pro Asp Tyr Trp Leu Ser Leu Leu Phe Lys Lys Leu Val Gly Thr 
                405                 410                 415     


Lys Val Leu Met Ala Ser Val Gln Gly Ser Lys Arg Arg Lys Leu Arg 
            420                 425                 430         


Val Tyr Leu His Cys Thr Asn Thr Asp Asn Pro Arg Tyr Lys Glu Gly 
        435                 440                 445             


Asp Leu Thr Leu Tyr Ala Ile Asn Leu His Asn Val Thr Lys Tyr Leu 
    450                 455                 460                 


Arg Leu Pro Tyr Pro Phe Ser Asn Lys Gln Val Asp Lys Tyr Leu Leu 
465                 470                 475                 480 


Arg Pro Leu Gly Pro His Gly Leu Leu Ser Lys Ser Val Gln Leu Asn 
                485                 490                 495     


Gly Leu Thr Leu Lys Met Val Asp Asp Gln Thr Leu Pro Pro Leu Met 
            500                 505                 510         


Glu Lys Pro Leu Arg Pro Gly Ser Ser Leu Gly Leu Pro Ala Phe Ser 
        515                 520                 525             


Tyr Ser Phe Phe Val Ile Arg Asn Ala Lys Val Ala Ala Cys Ile 
    530                 535                 540             


<210>  539
<211>  543
<212>  PRT
<213>  Homo sapiens

<400>  539

Met Leu Leu Arg Ser Lys Pro Ala Leu Pro Pro Pro Leu Met Leu Leu 
1               5                   10                  15      


Leu Leu Gly Pro Leu Gly Pro Leu Ser Pro Gly Ala Leu Pro Arg Pro 
            20                  25                  30          


Ala Gln Ala Gln Asp Val Val Asp Leu Asp Phe Phe Thr Gln Glu Pro 
        35                  40                  45              


Leu His Leu Val Ser Pro Ser Phe Leu Ser Val Thr Ile Asp Ala Asn 
    50                  55                  60                  


Leu Ala Thr Asp Pro Arg Phe Leu Ile Leu Leu Gly Ser Pro Lys Leu 
65                  70                  75                  80  


Arg Thr Leu Ala Arg Gly Leu Ser Pro Ala Tyr Leu Arg Phe Gly Gly 
                85                  90                  95      


Thr Lys Thr Asp Phe Leu Ile Phe Asp Pro Lys Lys Glu Ser Thr Phe 
            100                 105                 110         


Glu Glu Arg Ser Tyr Trp Gln Ser Gln Val Asn Gln Asp Ile Cys Lys 
        115                 120                 125             


Tyr Gly Ser Ile Pro Pro Asp Val Glu Glu Lys Leu Arg Leu Glu Trp 
    130                 135                 140                 


Pro Tyr Gln Glu Gln Leu Leu Leu Arg Glu His Tyr Gln Lys Lys Phe 
145                 150                 155                 160 


Lys Asn Ser Thr Tyr Ser Arg Ser Ser Val Asp Val Leu Tyr Thr Phe 
                165                 170                 175     


Ala Asn Cys Ser Gly Leu Asp Leu Ile Phe Gly Leu Asn Ala Leu Leu 
            180                 185                 190         


Arg Thr Ala Asp Leu Gln Trp Asn Ser Ser Asn Ala Gln Leu Leu Leu 
        195                 200                 205             


Asp Tyr Cys Ser Ser Lys Gly Tyr Asn Ile Ser Trp Glu Leu Gly Asn 
    210                 215                 220                 


Glu Pro Asn Ser Phe Leu Lys Lys Ala Asp Ile Phe Ile Asn Gly Ser 
225                 230                 235                 240 


Gln Leu Gly Glu Asp Phe Ile Gln Leu His Lys Leu Leu Arg Lys Ser 
                245                 250                 255     


Thr Phe Lys Asn Ala Lys Leu Tyr Gly Pro Asp Val Gly Gln Pro Arg 
            260                 265                 270         


Arg Lys Thr Ala Lys Met Leu Lys Ser Phe Leu Lys Ala Gly Gly Glu 
        275                 280                 285             


Val Ile Asp Ser Val Thr Trp His His Tyr Tyr Leu Asn Gly Arg Thr 
    290                 295                 300                 


Ala Thr Lys Glu Asp Phe Leu Asn Pro Asp Val Leu Asp Ile Phe Ile 
305                 310                 315                 320 


Ser Ser Val Gln Lys Val Phe Gln Val Val Glu Ser Thr Arg Pro Gly 
                325                 330                 335     


Lys Lys Val Trp Leu Gly Glu Thr Ser Ser Ala Tyr Gly Gly Gly Ala 
            340                 345                 350         


Pro Leu Leu Ser Asp Thr Phe Ala Ala Gly Phe Met Trp Leu Asp Lys 
        355                 360                 365             


Leu Gly Leu Ser Ala Arg Met Gly Ile Glu Val Val Met Arg Gln Val 
    370                 375                 380                 


Phe Phe Gly Ala Gly Asn Tyr His Leu Val Asp Glu Asn Phe Asp Pro 
385                 390                 395                 400 


Leu Pro Asp Tyr Trp Leu Ser Leu Leu Phe Lys Lys Leu Val Gly Thr 
                405                 410                 415     


Lys Val Leu Met Ala Ser Val Gln Gly Ser Lys Arg Arg Lys Leu Arg 
            420                 425                 430         


Val Tyr Leu His Cys Thr Asn Thr Asp Asn Pro Arg Tyr Lys Glu Gly 
        435                 440                 445             


Asp Leu Thr Leu Tyr Ala Ile Asn Leu His Asn Val Thr Lys Tyr Leu 
    450                 455                 460                 


Arg Leu Pro Tyr Pro Phe Ser Asn Lys Gln Val Asp Lys Tyr Leu Leu 
465                 470                 475                 480 


Arg Pro Leu Gly Pro His Gly Leu Leu Ser Lys Ser Val Gln Leu Asn 
                485                 490                 495     


Gly Leu Thr Leu Lys Met Val Asp Asp Gln Thr Leu Pro Pro Leu Met 
            500                 505                 510         


Glu Lys Pro Leu Arg Pro Gly Ser Ser Leu Gly Leu Pro Ala Phe Ser 
        515                 520                 525             


Tyr Ser Phe Phe Val Ile Arg Asn Ala Lys Val Ala Ala Cys Ile 
    530                 535                 540             


<210>  540
<211>  226
<212>  PRT
<213>  Homo sapiens

<400>  540

Met Leu Leu Arg Ser Lys Pro Ala Leu Pro Pro Pro Leu Met Leu Leu 
1               5                   10                  15      


Leu Leu Gly Pro Leu Gly Pro Leu Ser Pro Gly Ala Leu Pro Arg Pro 
            20                  25                  30          


Ala Gln Ala Gln Asp Val Val Asp Leu Asp Phe Phe Thr Gln Glu Pro 
        35                  40                  45              


Leu His Leu Val Ser Pro Ser Phe Leu Ser Val Thr Ile Asp Ala Asn 
    50                  55                  60                  


Leu Ala Thr Asp Pro Arg Phe Leu Ile Leu Leu Gly Ser Pro Lys Leu 
65                  70                  75                  80  


Arg Thr Leu Ala Arg Gly Leu Ser Pro Ala Tyr Leu Arg Phe Gly Gly 
                85                  90                  95      


Thr Lys Thr Asp Phe Leu Ile Phe Asp Pro Lys Lys Glu Ser Thr Phe 
            100                 105                 110         


Glu Glu Arg Ser Tyr Trp Gln Ser Gln Val Asn Gln Asp Ile Cys Lys 
        115                 120                 125             


Tyr Gly Ser Ile Pro Pro Asp Val Glu Glu Lys Leu Arg Leu Glu Trp 
    130                 135                 140                 


Pro Tyr Gln Glu Gln Leu Leu Leu Arg Glu His Tyr Gln Lys Lys Phe 
145                 150                 155                 160 


Lys Asn Ser Thr Tyr Ser Arg Ser Ser Val Asp Val Leu Tyr Thr Phe 
                165                 170                 175     


Ala Asn Cys Ser Gly Leu Asp Leu Ile Phe Gly Leu Asn Ala Leu Leu 
            180                 185                 190         


Arg Thr Ala Asp Leu Gln Trp Asn Ser Ser Asn Ala Gln Leu Leu Leu 
        195                 200                 205             


Asp Tyr Cys Ser Ser Lys Gly Tyr Asn Ile Ser Trp Glu Leu Gly Asn 
    210                 215                 220                 


Ala Ser 
225     


<210>  541
<211>  168
<212>  PRT
<213>  Homo sapiens

<400>  541

Met Leu Leu Arg Ser Lys Pro Ala Leu Pro Pro Pro Leu Met Leu Leu 
1               5                   10                  15      


Leu Leu Gly Pro Leu Gly Pro Leu Ser Pro Gly Ala Leu Pro Arg Pro 
            20                  25                  30          


Ala Gln Ala Gln Asp Val Val Asp Leu Asp Phe Phe Thr Gln Glu Pro 
        35                  40                  45              


Leu His Leu Val Ser Pro Ser Phe Leu Ser Val Thr Ile Asp Ala Asn 
    50                  55                  60                  


Leu Ala Thr Asp Pro Arg Phe Leu Ile Leu Leu Gly Ser Pro Lys Leu 
65                  70                  75                  80  


Arg Thr Leu Ala Arg Gly Leu Ser Pro Ala Tyr Leu Arg Phe Gly Gly 
                85                  90                  95      


Thr Lys Thr Asp Phe Leu Ile Phe Asp Pro Lys Lys Glu Ser Thr Phe 
            100                 105                 110         


Glu Glu Arg Ser Tyr Trp Gln Ser Gln Val Asn Gln Asp Ile Cys Lys 
        115                 120                 125             


Tyr Gly Ser Ile Pro Pro Asp Val Glu Glu Lys Leu Arg Leu Glu Trp 
    130                 135                 140                 


Pro Tyr Gln Glu Gln Leu Leu Leu Arg Glu His Tyr Gln Lys Lys Phe 
145                 150                 155                 160 


Lys Asn Ser Thr Tyr Ser Thr Ser 
                165             


<210>  542
<211>  380
<212>  PRT
<213>  Homo sapiens

<400>  542

Met Leu Leu Arg Ser Lys Pro Ala Leu Pro Pro Pro Leu Met Leu Leu 
1               5                   10                  15      


Leu Leu Gly Pro Leu Gly Pro Leu Ser Pro Gly Ala Leu Pro Arg Pro 
            20                  25                  30          


Ala Gln Ala Gln Asp Val Val Asp Leu Asp Phe Phe Thr Gln Glu Pro 
        35                  40                  45              


Leu His Leu Val Ser Pro Ser Phe Leu Ser Val Thr Ile Asp Ala Asn 
    50                  55                  60                  


Leu Ala Thr Asp Pro Arg Phe Leu Ile Leu Leu Gly Ser Pro Lys Leu 
65                  70                  75                  80  


Arg Thr Leu Ala Arg Gly Leu Ser Pro Ala Tyr Leu Arg Phe Gly Gly 
                85                  90                  95      


Thr Lys Thr Asp Phe Leu Ile Phe Asp Pro Lys Lys Glu Ser Thr Phe 
            100                 105                 110         


Glu Glu Arg Ser Tyr Trp Gln Ser Gln Val Asn Gln Asp Ile Cys Lys 
        115                 120                 125             


Tyr Gly Ser Ile Pro Pro Asp Val Glu Glu Lys Leu Arg Leu Glu Trp 
    130                 135                 140                 


Pro Tyr Gln Glu Gln Leu Leu Leu Arg Glu His Tyr Gln Lys Lys Phe 
145                 150                 155                 160 


Lys Asn Ser Thr Tyr Ser Arg Ser Ser Val Asp Val Leu Tyr Thr Phe 
                165                 170                 175     


Ala Asn Cys Ser Gly Leu Asp Leu Ile Phe Gly Leu Asn Ala Leu Leu 
            180                 185                 190         


Arg Thr Ala Asp Leu Gln Trp Asn Ser Ser Asn Ala Gln Leu Leu Leu 
        195                 200                 205             


Asp Tyr Cys Ser Ser Lys Gly Tyr Asn Ile Ser Trp Glu Leu Gly Asn 
    210                 215                 220                 


Glu Pro Asn Ser Phe Leu Lys Lys Ala Asp Ile Phe Ile Asn Gly Ser 
225                 230                 235                 240 


Gln Leu Gly Glu Asp Phe Ile Gln Leu His Lys Leu Leu Arg Lys Ser 
                245                 250                 255     


Thr Phe Lys Asn Ala Lys Leu Tyr Gly Pro Asp Val Gly Gln Pro Arg 
            260                 265                 270         


Arg Lys Thr Ala Lys Met Leu Lys Ser Phe Leu Lys Ala Gly Gly Glu 
        275                 280                 285             


Val Ile Asp Ser Val Thr Trp His His Tyr Tyr Leu Asn Gly Arg Thr 
    290                 295                 300                 


Ala Thr Lys Glu Asp Phe Leu Asn Pro Asp Val Leu Asp Ile Phe Ile 
305                 310                 315                 320 


Ser Ser Val Gln Lys Val Phe Gln Val Val Glu Ser Thr Arg Pro Gly 
                325                 330                 335     


Lys Lys Val Trp Leu Gly Glu Thr Ser Ser Ala Tyr Gly Gly Gly Ala 
            340                 345                 350         


Pro Leu Leu Ser Asp Thr Phe Ala Ala Gly Phe Met Ile Ile Gly Tyr 
        355                 360                 365             


Leu Phe Cys Ser Arg Asn Trp Trp Ala Pro Arg Cys 
    370                 375                 380 


<210>  543
<211>  469
<212>  PRT
<213>  Homo sapiens

<400>  543

Met Leu Leu Arg Ser Lys Pro Ala Leu Pro Pro Pro Leu Met Leu Leu 
1               5                   10                  15      


Leu Leu Gly Pro Leu Gly Pro Leu Ser Pro Gly Ala Leu Pro Arg Pro 
            20                  25                  30          


Ala Gln Ala Gln Asp Val Val Asp Leu Asp Phe Phe Thr Gln Glu Pro 
        35                  40                  45              


Leu His Leu Val Ser Pro Ser Phe Leu Ser Val Thr Ile Asp Ala Asn 
    50                  55                  60                  


Leu Ala Thr Asp Pro Arg Phe Leu Ile Leu Leu Gly Ser Pro Lys Leu 
65                  70                  75                  80  


Arg Thr Leu Ala Arg Gly Leu Ser Pro Ala Tyr Leu Arg Phe Gly Gly 
                85                  90                  95      


Thr Lys Thr Asp Phe Leu Ile Phe Asp Pro Lys Lys Glu Ser Thr Phe 
            100                 105                 110         


Glu Glu Arg Ser Tyr Trp Gln Ser Gln Val Asn Gln Asp Ile Cys Lys 
        115                 120                 125             


Tyr Gly Ser Ile Pro Pro Asp Val Glu Glu Lys Leu Arg Leu Glu Trp 
    130                 135                 140                 


Pro Tyr Gln Glu Gln Leu Leu Leu Arg Glu His Tyr Gln Lys Lys Phe 
145                 150                 155                 160 


Lys Asn Ser Thr Tyr Ser Arg Ser Ser Val Asp Val Leu Tyr Thr Phe 
                165                 170                 175     


Ala Asn Cys Ser Gly Leu Asp Leu Ile Phe Gly Leu Asn Ala Leu Leu 
            180                 185                 190         


Arg Thr Ala Asp Leu Gln Trp Asn Ser Ser Asn Ala Gln Leu Leu Leu 
        195                 200                 205             


Asp Tyr Cys Ser Ser Lys Gly Tyr Asn Ile Ser Trp Glu Leu Gly Asn 
    210                 215                 220                 


Glu Pro Asn Ser Phe Leu Lys Lys Ala Asp Ile Phe Ile Asn Gly Ser 
225                 230                 235                 240 


Gln Leu Gly Glu Asp Phe Ile Gln Leu His Lys Leu Leu Arg Lys Ser 
                245                 250                 255     


Thr Phe Lys Asn Ala Lys Leu Tyr Gly Pro Asp Val Gly Gln Pro Arg 
            260                 265                 270         


Arg Lys Thr Ala Lys Met Leu Lys Ser Phe Leu Lys Ala Gly Gly Glu 
        275                 280                 285             


Val Ile Asp Ser Val Thr Trp His His Tyr Tyr Leu Asn Gly Arg Thr 
    290                 295                 300                 


Ala Thr Lys Glu Asp Phe Leu Asn Pro Asp Val Leu Asp Ile Phe Ile 
305                 310                 315                 320 


Ser Ser Val Gln Lys Val Phe Gln Asp Tyr Trp Leu Ser Leu Leu Phe 
                325                 330                 335     


Lys Lys Leu Val Gly Thr Lys Val Leu Met Ala Ser Val Gln Gly Ser 
            340                 345                 350         


Lys Arg Arg Lys Leu Arg Val Tyr Leu His Cys Thr Asn Thr Asp Asn 
        355                 360                 365             


Pro Arg Tyr Lys Glu Gly Asp Leu Thr Leu Tyr Ala Ile Asn Leu His 
    370                 375                 380                 


Asn Val Thr Lys Tyr Leu Arg Leu Pro Tyr Pro Phe Ser Asn Lys Gln 
385                 390                 395                 400 


Val Asp Lys Tyr Leu Leu Arg Pro Leu Gly Pro His Gly Leu Leu Ser 
                405                 410                 415     


Lys Ser Val Gln Leu Asn Gly Leu Thr Leu Lys Met Val Asp Asp Gln 
            420                 425                 430         


Thr Leu Pro Pro Leu Met Glu Lys Pro Leu Arg Pro Gly Ser Ser Leu 
        435                 440                 445             


Gly Leu Pro Ala Phe Ser Tyr Ser Phe Phe Val Ile Arg Asn Ala Lys 
    450                 455                 460                 


Val Ala Ala Cys Ile 
465                 


<210>  544
<211>  485
<212>  PRT
<213>  Homo sapiens

<400>  544

Met Leu Leu Arg Ser Lys Pro Ala Leu Pro Pro Pro Leu Met Leu Leu 
1               5                   10                  15      


Leu Leu Gly Pro Leu Gly Pro Leu Ser Pro Gly Ala Leu Pro Arg Pro 
            20                  25                  30          


Ala Gln Ala Gln Asp Val Val Asp Leu Asp Phe Phe Thr Gln Glu Pro 
        35                  40                  45              


Leu His Leu Val Ser Pro Ser Phe Leu Ser Val Thr Ile Asp Ala Asn 
    50                  55                  60                  


Leu Ala Thr Asp Pro Arg Phe Leu Ile Leu Leu Gly Ser Pro Lys Leu 
65                  70                  75                  80  


Arg Thr Leu Ala Arg Gly Leu Ser Pro Ala Tyr Leu Arg Phe Gly Gly 
                85                  90                  95      


Thr Lys Thr Asp Phe Leu Ile Phe Asp Pro Lys Lys Glu Ser Thr Phe 
            100                 105                 110         


Glu Glu Arg Ser Tyr Trp Gln Ser Gln Val Asn Gln Asp Ile Cys Lys 
        115                 120                 125             


Tyr Gly Ser Ile Pro Pro Asp Val Glu Glu Lys Leu Arg Leu Glu Trp 
    130                 135                 140                 


Pro Tyr Gln Glu Gln Leu Leu Leu Arg Glu His Tyr Gln Lys Lys Phe 
145                 150                 155                 160 


Lys Asn Ser Thr Tyr Ser Lys Pro Asn Ser Phe Leu Lys Lys Ala Asp 
                165                 170                 175     


Ile Phe Ile Asn Gly Ser Gln Leu Gly Glu Asp Phe Ile Gln Leu His 
            180                 185                 190         


Lys Leu Leu Arg Lys Ser Thr Phe Lys Asn Ala Lys Leu Tyr Gly Pro 
        195                 200                 205             


Asp Val Gly Gln Pro Arg Arg Lys Thr Ala Lys Met Leu Lys Ser Phe 
    210                 215                 220                 


Leu Lys Ala Gly Gly Glu Val Ile Asp Ser Val Thr Trp His His Tyr 
225                 230                 235                 240 


Tyr Leu Asn Gly Arg Thr Ala Thr Lys Glu Asp Phe Leu Asn Pro Asp 
                245                 250                 255     


Val Leu Asp Ile Phe Ile Ser Ser Val Gln Lys Val Phe Gln Val Val 
            260                 265                 270         


Glu Ser Thr Arg Pro Gly Lys Lys Val Trp Leu Gly Glu Thr Ser Ser 
        275                 280                 285             


Ala Tyr Gly Gly Gly Ala Pro Leu Leu Ser Asp Thr Phe Ala Ala Gly 
    290                 295                 300                 


Phe Met Trp Leu Asp Lys Leu Gly Leu Ser Ala Arg Met Gly Ile Glu 
305                 310                 315                 320 


Val Val Met Arg Gln Val Phe Phe Gly Ala Gly Asn Tyr His Leu Val 
                325                 330                 335     


Asp Glu Asn Phe Asp Pro Leu Pro Asp Tyr Trp Leu Ser Leu Leu Phe 
            340                 345                 350         


Lys Lys Leu Val Gly Thr Lys Val Leu Met Ala Ser Val Gln Gly Ser 
        355                 360                 365             


Lys Arg Arg Lys Leu Arg Val Tyr Leu His Cys Thr Asn Thr Asp Asn 
    370                 375                 380                 


Pro Arg Tyr Lys Glu Gly Asp Leu Thr Leu Tyr Ala Ile Asn Leu His 
385                 390                 395                 400 


Asn Val Thr Lys Tyr Leu Arg Leu Pro Tyr Pro Phe Ser Asn Lys Gln 
                405                 410                 415     


Val Asp Lys Tyr Leu Leu Arg Pro Leu Gly Pro His Gly Leu Leu Ser 
            420                 425                 430         


Lys Ser Val Gln Leu Asn Gly Leu Thr Leu Lys Met Val Asp Asp Gln 
        435                 440                 445             


Thr Leu Pro Pro Leu Met Glu Lys Pro Leu Arg Pro Gly Ser Ser Leu 
    450                 455                 460                 


Gly Leu Pro Ala Phe Ser Tyr Ser Phe Phe Val Ile Arg Asn Ala Lys 
465                 470                 475                 480 


Val Ala Ala Cys Ile 
                485 


<210>  545
<211>  524
<212>  PRT
<213>  Homo sapiens

<400>  545

Met Asp Thr Glu Ser Thr Tyr Ser Gly Tyr Ser Tyr Tyr Ser Ser His 
1               5                   10                  15      


Ser Lys Lys Ser His Arg Gln Gly Glu Arg Thr Arg Glu Arg His Lys 
            20                  25                  30          


Ser Pro Arg Asn Lys Asp Gly Arg Gly Ser Glu Lys Ser Val Thr Ile 
        35                  40                  45              


Gln Pro Pro Thr Gly Glu Pro Leu Leu Gly Asn Asp Ser Thr Arg Thr 
    50                  55                  60                  


Glu Glu Val Gln Asp Asp Asn Trp Gly Glu Thr Thr Thr Ala Ile Thr 
65                  70                  75                  80  


Gly Thr Ser Glu His Ser Ile Ser Gln Glu Asp Ile Ala Arg Ile Ser 
                85                  90                  95      


Lys Asp Met Glu Asp Ser Val Gly Leu Asp Cys Lys Arg Tyr Leu Gly 
            100                 105                 110         


Leu Thr Val Ala Ser Phe Leu Gly Leu Leu Val Phe Leu Thr Pro Ile 
        115                 120                 125             


Ala Phe Ile Leu Leu Pro Pro Ile Leu Trp Arg Asp Glu Leu Glu Pro 
    130                 135                 140                 


Cys Gly Thr Ile Cys Glu Gly Leu Phe Ile Ser Met Ala Phe Lys Leu 
145                 150                 155                 160 


Leu Ile Leu Leu Ile Gly Thr Trp Ala Leu Phe Phe Arg Lys Arg Arg 
                165                 170                 175     


Ala Asp Met Pro Arg Val Phe Val Phe Arg Ala Leu Leu Leu Val Leu 
            180                 185                 190         


Ile Phe Leu Phe Val Val Ser Tyr Trp Leu Phe Tyr Gly Val Arg Ile 
        195                 200                 205             


Leu Asp Ser Arg Asp Arg Asn Tyr Gln Gly Ile Val Gln Tyr Ala Val 
    210                 215                 220                 


Ser Leu Val Asp Ala Leu Leu Phe Ile His Tyr Leu Ala Ile Val Leu 
225                 230                 235                 240 


Leu Glu Leu Arg Gln Leu Gln Pro Met Phe Thr Leu Gln Val Val Arg 
                245                 250                 255     


Ser Thr Asp Gly Glu Ser Arg Phe Tyr Ser Leu Gly His Leu Ser Ile 
            260                 265                 270         


Gln Arg Ala Ala Leu Val Val Leu Glu Asn Tyr Tyr Lys Asp Phe Thr 
        275                 280                 285             


Ile Tyr Asn Pro Asn Leu Leu Thr Ala Ser Lys Phe Arg Ala Ala Lys 
    290                 295                 300                 


His Met Ala Gly Leu Lys Val Tyr Asn Val Asp Gly Pro Ser Asn Asn 
305                 310                 315                 320 


Ala Thr Gly Gln Ser Arg Ala Met Ile Ala Ala Ala Ala Arg Arg Arg 
                325                 330                 335     


Asp Ser Ser His Asn Glu Leu Tyr Tyr Glu Glu Ala Glu His Glu Arg 
            340                 345                 350         


Arg Val Lys Lys Arg Lys Ala Arg Leu Val Val Ala Val Glu Glu Ala 
        355                 360                 365             


Phe Ile His Ile Gln Arg Leu Gln Ala Glu Glu Gln Gln Lys Ala Pro 
    370                 375                 380                 


Gly Glu Val Met Asp Pro Arg Glu Ala Ala Gln Ala Ile Phe Pro Ser 
385                 390                 395                 400 


Met Ala Arg Ala Leu Gln Lys Tyr Leu Arg Ile Thr Arg Gln Gln Asn 
                405                 410                 415     


Tyr His Ser Met Glu Ser Ile Leu Gln His Leu Ala Phe Cys Ile Thr 
            420                 425                 430         


Asn Gly Met Thr Pro Lys Ala Phe Leu Glu Arg Tyr Leu Ser Ala Gly 
        435                 440                 445             


Pro Thr Leu Gln Tyr Asp Lys Asp Arg Trp Leu Ser Thr Gln Trp Arg 
    450                 455                 460                 


Leu Val Ser Asp Glu Ala Val Thr Asn Gly Leu Arg Asp Gly Ile Val 
465                 470                 475                 480 


Phe Val Leu Lys Cys Leu Asp Phe Ser Leu Val Val Asn Val Lys Lys 
                485                 490                 495     


Ile Pro Phe Ile Ile Leu Ser Glu Glu Phe Ile Asp Pro Lys Ser His 
            500                 505                 510         


Lys Phe Val Leu Arg Leu Gln Ser Glu Thr Ser Val 
        515                 520                 


<210>  546
<211>  524
<212>  PRT
<213>  Homo sapiens

<400>  546

Met Asp Thr Glu Ser Thr Tyr Ser Gly Tyr Ser Tyr Tyr Ser Ser His 
1               5                   10                  15      


Ser Lys Lys Ser His Arg Gln Gly Glu Arg Thr Arg Glu Arg His Lys 
            20                  25                  30          


Ser Pro Arg Asn Lys Asp Gly Arg Gly Ser Glu Lys Ser Val Thr Ile 
        35                  40                  45              


Gln Pro Pro Thr Gly Glu Pro Leu Leu Gly Asn Asp Ser Thr Arg Thr 
    50                  55                  60                  


Glu Glu Val Gln Asp Asp Asn Trp Gly Glu Thr Thr Thr Ala Ile Thr 
65                  70                  75                  80  


Gly Thr Ser Glu His Ser Ile Ser Gln Glu Asp Ile Ala Arg Ile Ser 
                85                  90                  95      


Lys Asp Met Glu Asp Ser Val Gly Leu Asp Cys Lys Arg Tyr Leu Gly 
            100                 105                 110         


Leu Thr Val Ala Ser Phe Leu Gly Leu Leu Val Phe Leu Thr Pro Ile 
        115                 120                 125             


Ala Phe Ile Leu Leu Pro Pro Ile Leu Trp Arg Asp Glu Leu Glu Pro 
    130                 135                 140                 


Cys Gly Thr Ile Cys Glu Gly Leu Phe Ile Ser Met Ala Phe Lys Leu 
145                 150                 155                 160 


Leu Ile Leu Leu Ile Gly Thr Trp Ala Leu Phe Phe Arg Lys Arg Arg 
                165                 170                 175     


Ala Asp Met Pro Arg Val Phe Val Phe Arg Ala Leu Leu Leu Val Leu 
            180                 185                 190         


Ile Phe Leu Phe Val Val Ser Tyr Trp Leu Phe Tyr Gly Val Arg Ile 
        195                 200                 205             


Leu Asp Ser Arg Asp Arg Asn Tyr Gln Gly Ile Val Gln Tyr Ala Val 
    210                 215                 220                 


Ser Leu Val Asp Ala Leu Leu Phe Ile His Tyr Leu Ala Ile Val Leu 
225                 230                 235                 240 


Leu Glu Leu Arg Gln Leu Gln Pro Met Phe Thr Leu Gln Val Val Arg 
                245                 250                 255     


Ser Thr Asp Gly Glu Ser Arg Phe Tyr Ser Leu Gly His Leu Ser Ile 
            260                 265                 270         


Gln Arg Ala Ala Leu Val Val Leu Glu Asn Tyr Tyr Lys Asp Phe Thr 
        275                 280                 285             


Ile Tyr Asn Pro Asn Leu Leu Thr Ala Ser Lys Phe Arg Ala Ala Lys 
    290                 295                 300                 


His Met Ala Gly Leu Lys Val Tyr Asn Val Asp Gly Pro Ser Asn Asn 
305                 310                 315                 320 


Ala Thr Gly Gln Ser Arg Ala Met Ile Ala Ala Ala Ala Arg Arg Arg 
                325                 330                 335     


Asp Ser Ser His Asn Glu Leu Tyr Tyr Glu Glu Ala Glu His Glu Arg 
            340                 345                 350         


Arg Val Lys Lys Arg Lys Ala Arg Leu Val Val Ala Val Glu Glu Ala 
        355                 360                 365             


Phe Ile His Ile Gln Arg Leu Gln Ala Glu Glu Gln Gln Lys Ala Pro 
    370                 375                 380                 


Gly Glu Val Met Asp Pro Arg Glu Ala Ala Gln Ala Ile Phe Pro Ser 
385                 390                 395                 400 


Met Ala Arg Ala Leu Gln Lys Tyr Leu Arg Ile Thr Arg Gln Gln Asn 
                405                 410                 415     


Tyr His Ser Met Glu Ser Ile Leu Gln His Leu Ala Phe Cys Ile Thr 
            420                 425                 430         


Asn Gly Met Thr Pro Lys Ala Phe Leu Glu Arg Tyr Leu Ser Ala Gly 
        435                 440                 445             


Pro Thr Leu Gln Tyr Asp Lys Asp Arg Trp Leu Ser Thr Gln Trp Arg 
    450                 455                 460                 


Leu Val Ser Asp Glu Ala Val Thr Asn Gly Leu Arg Asp Gly Ile Val 
465                 470                 475                 480 


Phe Val Leu Lys Cys Leu Asp Phe Ser Leu Val Val Asn Val Lys Lys 
                485                 490                 495     


Ile Pro Phe Ile Ile Leu Ser Glu Glu Phe Ile Asp Pro Lys Ser His 
            500                 505                 510         


Lys Phe Val Leu Arg Leu Gln Ser Glu Thr Ser Val 
        515                 520                 


<210>  547
<211>  524
<212>  PRT
<213>  Homo sapiens

<400>  547

Met Asp Thr Glu Ser Thr Tyr Ser Gly Tyr Ser Tyr Tyr Ser Ser His 
1               5                   10                  15      


Ser Lys Lys Ser His Arg Gln Gly Glu Arg Thr Arg Glu Arg His Lys 
            20                  25                  30          


Ser Pro Arg Asn Lys Asp Gly Arg Gly Ser Glu Lys Ser Val Thr Ile 
        35                  40                  45              


Gln Pro Pro Thr Gly Glu Pro Leu Leu Gly Asn Asp Ser Thr Arg Thr 
    50                  55                  60                  


Glu Glu Val Gln Asp Asp Asn Trp Gly Glu Thr Thr Thr Ala Ile Thr 
65                  70                  75                  80  


Gly Thr Ser Glu His Ser Ile Ser Gln Glu Asp Ile Ala Arg Ile Ser 
                85                  90                  95      


Lys Asp Met Glu Asp Ser Val Gly Leu Asp Cys Lys Arg Tyr Leu Gly 
            100                 105                 110         


Leu Thr Val Ala Ser Phe Leu Gly Leu Leu Val Phe Leu Thr Pro Ile 
        115                 120                 125             


Ala Phe Ile Leu Leu Pro Pro Ile Leu Trp Arg Asp Glu Leu Glu Pro 
    130                 135                 140                 


Cys Gly Thr Ile Cys Glu Gly Leu Phe Ile Ser Met Ala Phe Lys Leu 
145                 150                 155                 160 


Leu Ile Leu Leu Ile Gly Thr Trp Ala Leu Phe Phe Arg Lys Arg Arg 
                165                 170                 175     


Ala Asp Met Pro Arg Val Phe Val Phe Arg Ala Leu Leu Leu Val Leu 
            180                 185                 190         


Ile Phe Leu Phe Val Val Ser Tyr Trp Leu Phe Tyr Gly Val Arg Ile 
        195                 200                 205             


Leu Asp Ser Arg Asp Arg Asn Tyr Gln Gly Ile Val Gln Tyr Ala Val 
    210                 215                 220                 


Ser Leu Val Asp Ala Leu Leu Phe Ile His Tyr Leu Ala Ile Val Leu 
225                 230                 235                 240 


Leu Glu Leu Arg Gln Leu Gln Pro Met Phe Thr Leu Gln Val Val Arg 
                245                 250                 255     


Ser Thr Asp Gly Glu Ser Arg Phe Tyr Ser Leu Gly His Leu Ser Ile 
            260                 265                 270         


Gln Arg Ala Ala Leu Val Val Leu Glu Asn Tyr Tyr Lys Asp Phe Thr 
        275                 280                 285             


Ile Tyr Asn Pro Asn Leu Leu Thr Ala Ser Lys Phe Arg Ala Ala Lys 
    290                 295                 300                 


His Met Ala Gly Leu Lys Val Tyr Asn Val Asp Gly Pro Ser Asn Asn 
305                 310                 315                 320 


Ala Thr Gly Gln Ser Arg Ala Met Ile Ala Ala Ala Ala Arg Arg Arg 
                325                 330                 335     


Asp Ser Ser His Asn Glu Leu Tyr Tyr Glu Glu Ala Glu His Glu Arg 
            340                 345                 350         


Arg Val Lys Lys Arg Lys Ala Arg Leu Val Val Ala Val Glu Glu Ala 
        355                 360                 365             


Phe Ile His Ile Gln Arg Leu Gln Ala Glu Glu Gln Gln Lys Ala Pro 
    370                 375                 380                 


Gly Glu Val Met Asp Pro Arg Glu Ala Ala Gln Ala Ile Phe Pro Ser 
385                 390                 395                 400 


Met Ala Arg Ala Leu Gln Lys Tyr Leu Arg Ile Thr Arg Gln Gln Asn 
                405                 410                 415     


Tyr His Ser Met Glu Ser Ile Leu Gln His Leu Ala Phe Cys Ile Thr 
            420                 425                 430         


Asn Gly Met Thr Pro Lys Ala Phe Leu Glu Arg Tyr Leu Ser Ala Gly 
        435                 440                 445             


Pro Thr Leu Gln Tyr Asp Lys Asp Arg Trp Leu Ser Thr Gln Trp Arg 
    450                 455                 460                 


Leu Val Ser Asp Glu Ala Val Thr Asn Gly Leu Arg Asp Gly Ile Val 
465                 470                 475                 480 


Phe Val Leu Lys Cys Leu Asp Phe Ser Leu Val Val Asn Val Lys Lys 
                485                 490                 495     


Ile Pro Phe Ile Ile Leu Ser Glu Glu Phe Ile Asp Pro Lys Ser His 
            500                 505                 510         


Lys Phe Val Leu Arg Leu Gln Ser Glu Thr Ser Val 
        515                 520                 


<210>  548
<211>  522
<212>  PRT
<213>  Homo sapiens

<400>  548

Met Asp Thr Glu Ser Thr Tyr Ser Gly Tyr Ser Tyr Tyr Ser Ser His 
1               5                   10                  15      


Ser Lys Lys Ser His Arg Gln Gly Glu Arg Thr Arg Glu Arg His Lys 
            20                  25                  30          


Ser Pro Arg Asn Lys Asp Gly Arg Gly Ser Glu Lys Ser Val Thr Ile 
        35                  40                  45              


Gln Pro Pro Thr Gly Glu Pro Leu Leu Gly Asn Asp Ser Thr Arg Thr 
    50                  55                  60                  


Glu Glu Asp Asp Asn Trp Gly Glu Thr Thr Thr Ala Ile Thr Gly Thr 
65                  70                  75                  80  


Ser Glu His Ser Ile Ser Gln Glu Asp Ile Ala Arg Ile Ser Lys Asp 
                85                  90                  95      


Met Glu Asp Ser Val Gly Leu Asp Cys Lys Arg Tyr Leu Gly Leu Thr 
            100                 105                 110         


Val Ala Ser Phe Leu Gly Leu Leu Val Phe Leu Thr Pro Ile Ala Phe 
        115                 120                 125             


Ile Leu Leu Pro Pro Ile Leu Trp Arg Asp Glu Leu Glu Pro Cys Gly 
    130                 135                 140                 


Thr Ile Cys Glu Gly Leu Phe Ile Ser Met Ala Phe Lys Leu Leu Ile 
145                 150                 155                 160 


Leu Leu Ile Gly Thr Trp Ala Leu Phe Phe Arg Lys Arg Arg Ala Asp 
                165                 170                 175     


Met Pro Arg Val Phe Val Phe Arg Ala Leu Leu Leu Val Leu Ile Phe 
            180                 185                 190         


Leu Phe Val Val Ser Tyr Trp Leu Phe Tyr Gly Val Arg Ile Leu Asp 
        195                 200                 205             


Ser Arg Asp Arg Asn Tyr Gln Gly Ile Val Gln Tyr Ala Val Ser Leu 
    210                 215                 220                 


Val Asp Ala Leu Leu Phe Ile His Tyr Leu Ala Ile Val Leu Leu Glu 
225                 230                 235                 240 


Leu Arg Gln Leu Gln Pro Met Phe Thr Leu Gln Val Val Arg Ser Thr 
                245                 250                 255     


Asp Gly Glu Ser Arg Phe Tyr Ser Leu Gly His Leu Ser Ile Gln Arg 
            260                 265                 270         


Ala Ala Leu Val Val Leu Glu Asn Tyr Tyr Lys Asp Phe Thr Ile Tyr 
        275                 280                 285             


Asn Pro Asn Leu Leu Thr Ala Ser Lys Phe Arg Ala Ala Lys His Met 
    290                 295                 300                 


Ala Gly Leu Lys Val Tyr Asn Val Asp Gly Pro Ser Asn Asn Ala Thr 
305                 310                 315                 320 


Gly Gln Ser Arg Ala Met Ile Ala Ala Ala Ala Arg Arg Arg Asp Ser 
                325                 330                 335     


Ser His Asn Glu Leu Tyr Tyr Glu Glu Ala Glu His Glu Arg Arg Val 
            340                 345                 350         


Lys Lys Arg Lys Ala Arg Leu Val Val Ala Val Glu Glu Ala Phe Ile 
        355                 360                 365             


His Ile Gln Arg Leu Gln Ala Glu Glu Gln Gln Lys Ala Pro Gly Glu 
    370                 375                 380                 


Val Met Asp Pro Arg Glu Ala Ala Gln Ala Ile Phe Pro Ser Met Ala 
385                 390                 395                 400 


Arg Ala Leu Gln Lys Tyr Leu Arg Ile Thr Arg Gln Gln Asn Tyr His 
                405                 410                 415     


Ser Met Glu Ser Ile Leu Gln His Leu Ala Phe Cys Ile Thr Asn Gly 
            420                 425                 430         


Met Thr Pro Lys Ala Phe Leu Glu Arg Tyr Leu Ser Ala Gly Pro Thr 
        435                 440                 445             


Leu Gln Tyr Asp Lys Asp Arg Trp Leu Ser Thr Gln Trp Arg Leu Val 
    450                 455                 460                 


Ser Asp Glu Ala Val Thr Asn Gly Leu Arg Asp Gly Ile Val Phe Val 
465                 470                 475                 480 


Leu Lys Cys Leu Asp Phe Ser Leu Val Val Asn Val Lys Lys Ile Pro 
                485                 490                 495     


Phe Ile Ile Leu Ser Glu Glu Phe Ile Asp Pro Lys Ser His Lys Phe 
            500                 505                 510         


Val Leu Arg Leu Gln Ser Glu Thr Ser Val 
        515                 520         


<210>  549
<211>  240
<212>  PRT
<213>  Homo sapiens

<400>  549

Met Ala Gly Pro Pro Arg Leu Leu Leu Leu Pro Leu Leu Leu Ala Leu 
1               5                   10                  15      


Ala Arg Gly Leu Pro Gly Ala Leu Ala Ala Gln Glu Val Gln Gln Ser 
            20                  25                  30          


Pro His Cys Thr Thr Val Pro Val Gly Ala Ser Val Asn Ile Thr Cys 
        35                  40                  45              


Ser Thr Ser Gly Gly Leu Arg Gly Ile Tyr Leu Arg Gln Leu Gly Pro 
    50                  55                  60                  


Gln Pro Gln Asp Ile Ile Tyr Tyr Glu Asp Gly Val Val Pro Thr Thr 
65                  70                  75                  80  


Asp Arg Arg Phe Arg Gly Arg Ile Asp Phe Ser Gly Ser Gln Asp Asn 
                85                  90                  95      


Leu Thr Ile Thr Met His Arg Leu Gln Leu Ser Asp Thr Gly Thr Tyr 
            100                 105                 110         


Thr Cys Gln Ala Ile Thr Glu Val Asn Val Tyr Gly Ser Gly Thr Leu 
        115                 120                 125             


Val Leu Val Thr Glu Glu Gln Ser Gln Gly Trp His Arg Cys Ser Asp 
    130                 135                 140                 


Ala Pro Pro Arg Ala Ser Ala Leu Pro Ala Pro Pro Thr Gly Ser Ala 
145                 150                 155                 160 


Leu Pro Asp Pro Gln Thr Ala Ser Ala Leu Pro Asp Pro Pro Ala Ala 
                165                 170                 175     


Ser Ala Leu Pro Ala Ala Leu Ala Val Ile Ser Phe Leu Leu Gly Leu 
            180                 185                 190         


Gly Leu Gly Val Ala Cys Val Leu Ala Arg Thr Gln Ile Lys Lys Leu 
        195                 200                 205             


Cys Ser Trp Arg Asp Lys Asn Ser Ala Ala Cys Val Val Tyr Glu Asp 
    210                 215                 220                 


Met Ser His Ser Arg Cys Asn Thr Leu Ser Ser Pro Asn Gln Tyr Gln 
225                 230                 235                 240 


<210>  550
<211>  121
<212>  PRT
<213>  Homo sapiens

<400>  550

Met His Arg Leu Gln Leu Ser Asp Thr Gly Thr Tyr Thr Cys Gln Ala 
1               5                   10                  15      


Ile Thr Glu Val Asn Val Tyr Gly Ser Gly Thr Leu Val Leu Val Thr 
            20                  25                  30          


Glu Glu Gln Ser Gln Gly Trp His Arg Cys Ser Asp Ala Pro Pro Arg 
        35                  40                  45              


Ala Ser Ala Leu Pro Ala Pro Pro Thr Gly Ser Ala Leu Pro Asp Pro 
    50                  55                  60                  


Gln Thr Ala Ser Ala Leu Pro Asp Pro Pro Ala Ala Ser Ala Leu Pro 
65                  70                  75                  80  


Ala Ala Leu Ala Val Ile Ser Phe Leu Leu Gly Leu Gly Leu Gly Val 
                85                  90                  95      


Ala Cys Val Leu Ala Arg Thr Gln Val Ser Val Ser Pro Ser Cys His 
            100                 105                 110         


Leu His Pro Lys Asp Cys Ser Leu Ser 
        115                 120     


<210>  551
<211>  35
<212>  PRT
<213>  Homo sapiens

<400>  551

Met Ala Gly Pro Pro Arg Leu Leu Leu Leu Pro Leu Leu Leu Ala Leu 
1               5                   10                  15      


Ala Arg Gly Leu Pro Gly Ala Leu Ala Ala Gln Ala Gly Ala Cys Val 
            20                  25                  30          


Gly Ser Thr 
        35  


<210>  552
<211>  160
<212>  PRT
<213>  Homo sapiens

<400>  552

Met Ala Gly Pro Pro Arg Leu Leu Leu Leu Pro Leu Leu Leu Ala Leu 
1               5                   10                  15      


Ala Arg Gly Leu Pro Gly Ala Leu Ala Ala Gln Gly Arg Thr Phe Ser 
            20                  25                  30          


Val Leu Leu Ala Arg Leu Met Val Thr Ala Gln Val Leu Pro Arg Gly 
        35                  40                  45              


Ala Ala Val Ser Pro Leu His Asp Cys Pro Arg Gly Ser Leu Arg Gln 
    50                  55                  60                  


His His Leu Leu His Gln Arg Gly Pro Ala Trp Asp Leu Pro Glu Ala 
65                  70                  75                  80  


Ala Arg Ala Thr Ala Pro Arg His His Leu Leu Arg Gly Arg Gly Gly 
                85                  90                  95      


Ala His Tyr Gly Gln Thr Val Pro Gly Pro His Arg Leu Leu Arg Val 
            100                 105                 110         


Pro Gly Gln Pro Asp Tyr His His Ala Pro Pro Ala Ala Val Gly His 
        115                 120                 125             


Trp His Leu His Leu Pro Gly His His Gly Gly Gln Cys Leu Arg Leu 
    130                 135                 140                 


Arg His Pro Gly Pro Gly Asp Arg Gly Thr Val Pro Arg Met Ala Gln 
145                 150                 155                 160 


<210>  553
<211>  140
<212>  PRT
<213>  Homo sapiens

<400>  553

Met His Arg Leu Gln Leu Ser Asp Thr Gly Thr Tyr Thr Cys Gln Ala 
1               5                   10                  15      


Ile Thr Glu Val Asn Val Tyr Gly Ser Gly Thr Leu Val Leu Val Thr 
            20                  25                  30          


Glu Glu Gln Ser Gln Gly Trp His Arg Cys Ser Asp Ala Pro Pro Arg 
        35                  40                  45              


Ala Ser Ala Leu Pro Ala Pro Pro Thr Gly Ser Ala Leu Pro Asp Pro 
    50                  55                  60                  


Gln Thr Ala Ser Ala Leu Pro Asp Pro Pro Ala Ala Ser Ala Leu Pro 
65                  70                  75                  80  


Ala Ala Leu Ala Val Ile Ser Phe Leu Leu Gly Leu Gly Leu Gly Val 
                85                  90                  95      


Ala Cys Val Leu Ala Arg Thr Gln Ile Lys Lys Leu Cys Ser Trp Arg 
            100                 105                 110         


Asp Lys Asn Ser Ala Ala Cys Val Val Tyr Glu Asp Met Ser His Ser 
        115                 120                 125             


Arg Cys Asn Thr Leu Ser Ser Pro Asn Gln Tyr Gln 
    130                 135                 140 


<210>  554
<211>  221
<212>  PRT
<213>  Homo sapiens

<400>  554

Met Ala Gly Pro Pro Arg Leu Leu Leu Leu Pro Leu Leu Leu Ala Leu 
1               5                   10                  15      


Ala Arg Gly Leu Pro Gly Ala Leu Ala Ala Gln Glu Val Gln Gln Ser 
            20                  25                  30          


Pro His Cys Thr Thr Val Pro Val Gly Ala Ser Val Asn Ile Thr Cys 
        35                  40                  45              


Ser Thr Ser Gly Gly Leu Arg Gly Ile Tyr Leu Arg Gln Leu Gly Pro 
    50                  55                  60                  


Gln Pro Gln Asp Ile Ile Tyr Tyr Glu Asp Gly Val Val Pro Thr Thr 
65                  70                  75                  80  


Asp Arg Arg Phe Arg Gly Arg Ile Asp Phe Ser Gly Ser Gln Asp Asn 
                85                  90                  95      


Leu Thr Ile Thr Met His Arg Leu Gln Leu Ser Asp Thr Gly Thr Tyr 
            100                 105                 110         


Thr Cys Gln Ala Ile Thr Glu Val Asn Val Tyr Gly Ser Gly Thr Leu 
        115                 120                 125             


Val Leu Val Thr Glu Glu Gln Ser Gln Gly Trp His Arg Cys Ser Asp 
    130                 135                 140                 


Ala Pro Pro Arg Ala Ser Ala Leu Pro Ala Pro Pro Thr Gly Ser Ala 
145                 150                 155                 160 


Leu Pro Asp Pro Gln Thr Ala Ser Ala Leu Pro Asp Pro Pro Ala Ala 
                165                 170                 175     


Ser Ala Leu Pro Ala Ala Leu Ala Val Ile Ser Phe Leu Leu Gly Leu 
            180                 185                 190         


Gly Leu Gly Val Ala Cys Val Leu Ala Arg Thr Gln Val Ser Val Ser 
        195                 200                 205             


Pro Ser Cys His Leu His Pro Lys Asp Cys Ser Leu Ser 
    210                 215                 220     


<210>  555
<211>  40
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  555

Xaa Asn Tyr Glu Met Pro Arg Gly Asp Thr Ser Ser Leu Arg Ala Pro 
1               5                   10                  15      


Ala Glu Asp Leu Arg Trp Val Glu Lys Thr Leu Ser Leu Leu Tyr Ser 
            20                  25                  30          


Pro Gln Val Ala Gly Ser Ser Arg 
        35                  40  


<210>  556
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  556

Met Gln Cys Gln Gly Tyr Val Ala Leu Leu Gly Ser Asp Asp Gln Ser 
1               5                   10                  15      


Trp Gly Trp Asn Leu Val Asp Asn Asn Leu Leu His Asn Gly Glu Val 
            20                  25                  30          


Asn Gly Ser Phe Pro Gln Cys Asn Asn Ala Pro Lys Tyr Gln Ile Gly 
        35                  40                  45              


Glu Arg Ile Arg Val Ile Leu Asp Met Glu Asp Lys Thr Leu Ala Phe 
    50                  55                  60                  


Glu Arg Gly Tyr Glu Phe Leu Gly Val Ala Phe Arg Gly Leu Pro Lys 
65                  70                  75                  80  


Val Cys Leu Tyr Pro Ala Val Ser Ala Val Tyr Gly Asn Thr Glu Val 
                85                  90                  95      


Thr Leu Val Tyr Leu Gly Lys Pro Leu Asp Gly 
            100                 105         


<210>  557
<211>  530
<212>  PRT
<213>  Homo sapiens

<400>  557

Met Ser Arg Ser Pro Gln Arg Ala Leu Pro Pro Gly Ala Leu Pro Arg 
1               5                   10                  15      


Leu Leu Gln Ala Ala Pro Ala Ala Ala Pro Arg Ala Leu Leu Pro Gln 
            20                  25                  30          


Trp Pro Arg Arg Pro Gly Arg Arg Trp Pro Ala Ser Pro Leu Gly Met 
        35                  40                  45              


Lys Val Phe Arg Arg Lys Ala Leu Val Leu Cys Ala Gly Tyr Ala Leu 
    50                  55                  60                  


Leu Leu Val Leu Thr Met Leu Asn Leu Leu Asp Tyr Lys Trp His Lys 
65                  70                  75                  80  


Glu Pro Leu Gln Gln Cys Asn Pro Asp Gly Pro Leu Gly Ala Ala Ala 
                85                  90                  95      


Gly Ala Ala Gly Gly Ser Trp Gly Arg Pro Gly Pro Pro Pro Ala Gly 
            100                 105                 110         


Pro Pro Arg Ala His Ala Arg Leu Asp Leu Arg Thr Pro Tyr Arg Pro 
        115                 120                 125             


Pro Ala Ala Ala Val Gly Ala Ala Pro Ala Ala Ala Ala Gly Met Ala 
    130                 135                 140                 


Gly Val Ala Ala Pro Pro Gly Asn Gly Thr Arg Gly Thr Gly Gly Val 
145                 150                 155                 160 


Gly Asp Lys Arg Gln Leu Val Tyr Val Phe Thr Thr Trp Arg Ser Gly 
                165                 170                 175     


Ser Ser Phe Phe Gly Glu Leu Phe Asn Gln Asn Pro Glu Val Phe Phe 
            180                 185                 190         


Leu Tyr Glu Pro Val Trp His Val Trp Gln Lys Leu Tyr Pro Gly Asp 
        195                 200                 205             


Ala Val Ser Leu Gln Gly Ala Ala Arg Asp Met Leu Ser Ala Leu Tyr 
    210                 215                 220                 


Arg Cys Asp Leu Ser Val Phe Gln Leu Tyr Ser Pro Ala Gly Ser Gly 
225                 230                 235                 240 


Gly Arg Asn Leu Thr Thr Leu Gly Ile Phe Gly Ala Ala Thr Asn Lys 
                245                 250                 255     


Val Val Cys Ser Ser Pro Leu Cys Pro Ala Tyr Arg Lys Glu Val Val 
            260                 265                 270         


Gly Leu Val Asp Asp Arg Val Cys Lys Lys Cys Pro Pro Gln Arg Leu 
        275                 280                 285             


Ala Arg Phe Glu Glu Glu Cys Arg Lys Tyr Arg Thr Leu Val Ile Lys 
    290                 295                 300                 


Gly Val Arg Val Phe Asp Val Ala Val Leu Ala Pro Leu Leu Arg Asp 
305                 310                 315                 320 


Pro Ala Leu Asp Leu Lys Val Ile His Leu Val Arg Asp Pro Arg Ala 
                325                 330                 335     


Val Ala Ser Ser Arg Ile Arg Ser Arg His Gly Leu Ile Arg Glu Ser 
            340                 345                 350         


Leu Gln Val Val Arg Ser Arg Asp Pro Arg Ala His Arg Met Pro Phe 
        355                 360                 365             


Leu Glu Ala Ala Gly His Lys Leu Gly Ala Lys Lys Glu Gly Val Gly 
    370                 375                 380                 


Gly Pro Ala Asp Tyr His Ala Leu Gly Ala Met Glu Val Ile Cys Asn 
385                 390                 395                 400 


Ser Met Ala Lys Thr Leu Gln Thr Ala Leu Gln Pro Pro Asp Trp Leu 
                405                 410                 415     


Gln Gly His Tyr Leu Val Val Arg Tyr Glu Asp Leu Val Gly Asp Pro 
            420                 425                 430         


Val Lys Thr Leu Arg Arg Val Tyr Asp Phe Val Gly Leu Leu Val Ser 
        435                 440                 445             


Pro Glu Met Glu Gln Phe Ala Leu Asn Met Thr Ser Gly Ser Gly Ser 
    450                 455                 460                 


Ser Ser Lys Pro Phe Val Val Ser Ala Arg Asn Ala Thr Gln Ala Ala 
465                 470                 475                 480 


Asn Ala Trp Arg Thr Ala Leu Thr Phe Gln Gln Ile Lys Gln Val Glu 
                485                 490                 495     


Glu Phe Cys Tyr Gln Pro Met Ala Val Leu Gly Tyr Glu Arg Val Asn 
            500                 505                 510         


Ser Pro Glu Glu Val Lys Asp Leu Ser Lys Thr Leu Leu Arg Lys Pro 
        515                 520                 525             


Arg Leu 
    530 


<210>  558
<211>  84
<212>  PRT
<213>  Homo sapiens

<400>  558

Met Lys Gln Thr Gln Val Gly Ser Leu Phe Ser Leu Gly Ile Arg Asn 
1               5                   10                  15      


Pro Glu Pro Gly Pro Val Ser Gly Thr Ala Val Pro Arg Gln Leu Ala 
            20                  25                  30          


Trp Lys Ser Gly Lys Tyr Val Met Val Met Gly Val Val Gln Ala Cys 
        35                  40                  45              


Ser Pro Glu Pro Cys Leu Gln Ala Val Lys Met Thr Asp Leu Ser Asp 
    50                  55                  60                  


Asn Pro Ile His Glu Ser Met Trp Glu Leu Glu Val Glu Asp Leu His 
65                  70                  75                  80  


Arg Asn Ile Pro 
                


<210>  559
<211>  313
<212>  PRT
<213>  Homo sapiens

<400>  559

Met Ala Leu Leu Val Asp Arg Val Arg Gly His Trp Arg Ile Ala Ala 
1               5                   10                  15      


Gly Leu Leu Phe Asn Leu Leu Val Ser Ile Cys Ile Val Phe Leu Asn 
            20                  25                  30          


Lys Trp Ile Tyr Val Tyr His Gly Phe Pro Asn Met Ser Leu Thr Leu 
        35                  40                  45              


Val His Phe Val Val Thr Trp Leu Gly Leu Tyr Ile Cys Gln Lys Leu 
    50                  55                  60                  


Asp Ile Phe Ala Pro Lys Ser Leu Pro Pro Ser Arg Leu Leu Leu Leu 
65                  70                  75                  80  


Ala Leu Ser Phe Cys Gly Phe Val Val Phe Thr Asn Leu Ser Leu Gln 
                85                  90                  95      


Asn Asn Thr Ile Gly Thr Tyr Gln Leu Ala Lys Ala Met Thr Thr Pro 
            100                 105                 110         


Val Ile Ile Ala Ile Gln Thr Phe Cys Tyr Gln Lys Thr Phe Ser Thr 
        115                 120                 125             


Arg Ile Gln Leu Thr Leu Ile Pro Ile Thr Leu Gly Val Ile Leu Asn 
    130                 135                 140                 


Ser Tyr Tyr Asp Val Lys Phe Asn Phe Leu Gly Met Val Phe Ala Ala 
145                 150                 155                 160 


Leu Gly Val Leu Val Thr Ser Leu Tyr Gln Val Trp Val Gly Ala Lys 
                165                 170                 175     


Gln His Glu Leu Gln Val Asn Ser Met Gln Leu Leu Tyr Tyr Gln Ala 
            180                 185                 190         


Pro Met Ser Ser Ala Met Leu Leu Val Ala Val Pro Phe Phe Glu Pro 
        195                 200                 205             


Val Phe Gly Glu Gly Gly Ile Phe Gly Pro Trp Ser Val Ser Ala Leu 
    210                 215                 220                 


Leu Met Val Leu Leu Ser Gly Val Ile Ala Phe Met Val Asn Leu Ser 
225                 230                 235                 240 


Ile Tyr Trp Ile Ile Gly Asn Thr Ser Pro Val Thr Tyr Asn Met Phe 
                245                 250                 255     


Gly His Phe Lys Phe Cys Ile Thr Leu Phe Gly Gly Tyr Val Leu Phe 
            260                 265                 270         


Lys Asp Pro Leu Ser Ile Asn Gln Ala Leu Gly Ile Leu Cys Thr Leu 
        275                 280                 285             


Phe Gly Ile Leu Ala Tyr Thr His Phe Lys Leu Ser Glu Gln Glu Gly 
    290                 295                 300                 


Ser Arg Ser Lys Leu Ala Gln Arg Pro 
305                 310             


<210>  560
<211>  125
<212>  PRT
<213>  Homo sapiens

<400>  560

Gln Ala Pro Met Ser Ser Ala Met Leu Leu Val Ala Val Pro Phe Phe 
1               5                   10                  15      


Glu Pro Val Phe Gly Glu Gly Gly Ile Phe Gly Pro Trp Ser Val Ser 
            20                  25                  30          


Ala Leu Ser Thr Arg Leu Glu Cys Ser Gly Thr Ile Met Ala His Cys 
        35                  40                  45              


Ser Leu Ser Leu Leu Gly Ser Ser Asn Pro Pro Ala Ser Thr Ser Pro 
    50                  55                  60                  


Val Ala Gly Thr Thr Gly Ala His Gln His Thr Trp Leu Ile Phe Ile 
65                  70                  75                  80  


Phe Phe Val Glu Thr Glu Phe Cys His Val Ala Gln Ala Asp Leu Lys 
                85                  90                  95      


Leu Leu Ser Ser Ser His Leu Ser Ala Ser Ala Ser Arg Ser Ala Gly 
            100                 105                 110         


Ile Thr Gly Leu Ser His His Thr Trp Pro Val Ile Ser 
        115                 120                 125 


<210>  561
<211>  34
<212>  PRT
<213>  Homo sapiens

<400>  561

Met Thr Val Met Ser Leu Ser Arg Asp Leu Lys Asp Asp Phe His Ser 
1               5                   10                  15      


Asp Thr Val Leu Ser Ile Leu Asn Glu Gln Arg Ile Arg Gly Ile Leu 
            20                  25                  30          


Cys Asp 
        


<210>  562
<211>  193
<212>  PRT
<213>  Homo sapiens

<400>  562

Met Ala Glu Ala Glu Glu Ser Pro Gly Asp Pro Gly Thr Ala Ser Pro 
1               5                   10                  15      


Arg Pro Leu Met Arg Asp Leu Lys Ala Val Gly Lys Lys Phe Met His 
            20                  25                  30          


Val Leu Tyr Pro Arg Lys Ser Asn Thr Leu Leu Arg Asp Trp Asp Leu 
        35                  40                  45              


Trp Gly Pro Leu Ile Leu Cys Val Thr Leu Ala Leu Met Leu Gln Arg 
    50                  55                  60                  


Asp Ser Ala Asp Ser Glu Lys Asp Gly Gly Pro Gln Phe Ala Glu Val 
65                  70                  75                  80  


Phe Val Ile Val Trp Phe Gly Ala Val Thr Ile Thr Leu Asn Ser Lys 
                85                  90                  95      


Leu Leu Gly Gly Asn Ile Ser Phe Phe Gln Ser Leu Cys Val Leu Gly 
            100                 105                 110         


Tyr Cys Ile Leu Pro Leu Thr Val Ala Met Leu Ile Cys Arg Leu Val 
        115                 120                 125             


Leu Leu Ala Asp Pro Gly Pro Val Asn Phe Met Val Arg Leu Phe Val 
    130                 135                 140                 


Val Ile Val Met Phe Ala Trp Ser Ile Val Ala Ser Thr Ala Phe Leu 
145                 150                 155                 160 


Ala Asp Ser Gln Pro Pro Asn Arg Arg Ala Leu Ala Val Tyr Pro Val 
                165                 170                 175     


Phe Leu Phe Tyr Phe Val Ile Ser Trp Met Ile Leu Thr Phe Thr Pro 
            180                 185                 190         


Gln 
    


<210>  563
<211>  188
<212>  PRT
<213>  Homo sapiens

<400>  563

Met Ala Glu Ala Glu Glu Ser Pro Gly Asp Pro Gly Thr Ala Ser Pro 
1               5                   10                  15      


Arg Pro Leu Met Arg Asp Leu Lys Ala Val Gly Lys Lys Phe Met His 
            20                  25                  30          


Val Leu Tyr Pro Arg Lys Ser Asn Thr Leu Leu Arg Asp Trp Asp Leu 
        35                  40                  45              


Trp Gly Pro Leu Ile Leu Cys Val Thr Leu Ala Leu Met Leu Gln Arg 
    50                  55                  60                  


Asp Ser Ala Asp Ser Glu Lys Asp Gly Gly Pro Gln Phe Ala Glu Val 
65                  70                  75                  80  


Phe Val Ile Val Trp Phe Gly Ala Val Thr Ile Thr Leu Asn Ser Lys 
                85                  90                  95      


Leu Leu Gly Gly Asn Ile Ser Phe Phe Gln Ser Leu Cys Val Leu Gly 
            100                 105                 110         


Tyr Cys Ile Leu Pro Leu Thr Val Ala Met Leu Ile Cys Arg Leu Val 
        115                 120                 125             


Leu Leu Ala Asp Pro Gly Pro Val Asn Phe Met Val Arg Leu Phe Val 
    130                 135                 140                 


Val Ile Val Met Phe Ala Trp Ser Ile Val Ala Ser Thr Ala Phe Leu 
145                 150                 155                 160 


Ala Asp Ser Gln Pro Pro Asn Arg Arg Ala Leu Ala Val Tyr Pro Val 
                165                 170                 175     


Phe Leu Phe Tyr Phe Val Ile Ser Trp Met Ile Leu 
            180                 185             


<210>  564
<211>  236
<212>  PRT
<213>  Homo sapiens

<400>  564

Met Ala Glu Ala Glu Glu Ser Pro Gly Asp Pro Gly Thr Ala Ser Pro 
1               5                   10                  15      


Arg Pro Leu Phe Ala Gly Leu Ser Asp Ile Ser Ile Ser Gln Asp Ile 
            20                  25                  30          


Pro Val Glu Gly Glu Ile Thr Ile Pro Met Arg Ser Arg Ile Arg Glu 
        35                  40                  45              


Phe Asp Ser Ser Thr Leu Asn Glu Ser Val Arg Asn Thr Ile Met Arg 
    50                  55                  60                  


Asp Leu Lys Ala Val Gly Lys Lys Phe Met His Val Leu Tyr Pro Arg 
65                  70                  75                  80  


Lys Ser Asn Thr Leu Leu Arg Asp Trp Asp Leu Trp Gly Pro Leu Ile 
                85                  90                  95      


Leu Cys Val Thr Leu Ala Leu Met Leu Gln Arg Asp Ser Ala Asp Ser 
            100                 105                 110         


Glu Lys Asp Gly Gly Pro Gln Phe Ala Glu Val Phe Val Ile Val Trp 
        115                 120                 125             


Phe Gly Ala Val Thr Ile Thr Leu Asn Ser Lys Leu Leu Gly Gly Asn 
    130                 135                 140                 


Ile Ser Phe Phe Gln Ser Leu Cys Val Leu Gly Tyr Cys Ile Leu Pro 
145                 150                 155                 160 


Leu Thr Val Ala Met Leu Ile Cys Arg Leu Val Leu Leu Ala Asp Pro 
                165                 170                 175     


Gly Pro Val Asn Phe Met Val Arg Leu Phe Val Val Ile Val Met Phe 
            180                 185                 190         


Ala Trp Ser Ile Val Ala Ser Thr Ala Phe Leu Ala Asp Ser Gln Pro 
        195                 200                 205             


Pro Asn Arg Arg Ala Leu Ala Val Tyr Pro Val Phe Leu Phe Tyr Phe 
    210                 215                 220                 


Val Ile Ser Trp Met Ile Leu Thr Phe Thr Pro Gln 
225                 230                 235     


<210>  565
<211>  520
<212>  PRT
<213>  Homo sapiens

<400>  565

Met Glu Val Leu Glu Ser Gly Glu Gln Gly Val Leu Gln Trp Asp Arg 
1               5                   10                  15      


Lys Leu Ser Glu Leu Ser Glu Pro Gly Asp Gly Glu Ala Leu Met Tyr 
            20                  25                  30          


His Thr His Phe Ser Glu Leu Leu Asp Glu Phe Ser Gln Asn Val Leu 
        35                  40                  45              


Gly Gln Leu Leu Asn Asp Pro Phe Leu Ser Glu Lys Ser Val Ser Met 
    50                  55                  60                  


Glu Val Glu Pro Ser Pro Thr Ser Pro Ala Pro Leu Ile Gln Ala Glu 
65                  70                  75                  80  


His Ser Tyr Ser Leu Cys Glu Glu Pro Arg Ala Gln Ser Pro Phe Thr 
                85                  90                  95      


His Ile Thr Thr Ser Asp Ser Phe Asn Asp Asp Glu Val Glu Ser Glu 
            100                 105                 110         


Lys Trp Tyr Leu Ser Thr Asp Phe Pro Ser Thr Ser Ile Lys Thr Glu 
        115                 120                 125             


Pro Val Thr Asp Glu Pro Pro Pro Gly Leu Val Pro Ser Val Thr Leu 
    130                 135                 140                 


Thr Ile Thr Ala Ile Ser Thr Pro Leu Glu Lys Glu Glu Pro Pro Leu 
145                 150                 155                 160 


Glu Met Asn Thr Gly Val Asp Ser Ser Cys Gln Thr Ile Ile Pro Lys 
                165                 170                 175     


Ile Lys Leu Glu Pro His Glu Val Asp Gln Phe Leu Asn Phe Ser Pro 
            180                 185                 190         


Lys Glu Ala Pro Val Asp His Leu His Leu Pro Pro Thr Pro Pro Ser 
        195                 200                 205             


Ser His Gly Ser Asp Ser Glu Gly Ser Leu Ser Pro Asn Pro Arg Leu 
    210                 215                 220                 


His Pro Phe Ser Leu Pro Gln Thr His Ser Pro Ser Arg Ala Ala Pro 
225                 230                 235                 240 


Arg Ala Pro Ser Ala Leu Ser Ser Ser Pro Leu Leu Thr Ala Pro His 
                245                 250                 255     


Lys Leu Gln Gly Ser Gly Pro Leu Val Leu Thr Glu Glu Glu Lys Arg 
            260                 265                 270         


Thr Leu Ile Ala Glu Gly Tyr Pro Ile Pro Thr Lys Leu Pro Leu Ser 
        275                 280                 285             


Lys Ser Glu Glu Lys Ala Leu Lys Lys Ile Arg Arg Lys Ile Lys Asn 
    290                 295                 300                 


Lys Ile Ser Ala Gln Glu Ser Arg Arg Lys Lys Lys Glu Tyr Met Asp 
305                 310                 315                 320 


Ser Leu Glu Lys Lys Val Glu Ser Cys Ser Thr Glu Asn Leu Glu Leu 
                325                 330                 335     


Arg Lys Lys Val Glu Val Leu Glu Asn Thr Asn Arg Thr Leu Leu Gln 
            340                 345                 350         


Gln Leu Gln Lys Leu Gln Thr Leu Val Met Gly Lys Val Ser Arg Thr 
        355                 360                 365             


Cys Lys Leu Ala Gly Thr Gln Thr Gly Thr Cys Leu Met Val Val Val 
    370                 375                 380                 


Leu Cys Phe Ala Val Ala Phe Gly Ser Phe Phe Gln Gly Tyr Gly Pro 
385                 390                 395                 400 


Tyr Pro Ser Ala Thr Lys Met Ala Leu Pro Ser Gln His Ser Leu Gln 
                405                 410                 415     


Glu Pro Tyr Thr Ala Ser Val Val Arg Ser Arg Asn Leu Leu Ile Tyr 
            420                 425                 430         


Glu Glu His Ser Pro Pro Glu Glu Ser Ser Ser Pro Gly Ser Ala Gly 
        435                 440                 445             


Glu Leu Gly Gly Trp Asp Arg Gly Ser Ser Leu Leu Arg Val Ser Gly 
    450                 455                 460                 


Leu Glu Ser Arg Pro Asp Val Asp Leu Pro His Phe Ile Ile Ser Asn 
465                 470                 475                 480 


Glu Thr Ser Leu Glu Lys Ser Val Leu Leu Glu Leu Gln Gln His Leu 
                485                 490                 495     


Val Ser Ala Lys Leu Glu Gly Asn Glu Thr Leu Lys Val Val Glu Leu 
            500                 505                 510         


Asp Arg Arg Val Asn Thr Thr Phe 
        515                 520 


<210>  566
<211>  240
<212>  PRT
<213>  Homo sapiens

<400>  566

Asn Leu Pro Arg Arg Pro Arg Arg Leu Ser Ser Arg Leu Ser Thr Ala 
1               5                   10                  15      


Thr Pro Cys Ala Arg Ser Leu Gly Pro Ser Arg Pro Ser Pro Thr Leu 
            20                  25                  30          


Pro Pro Val Thr Ala Ser Met Thr Ile Cys Tyr Ile Asn Ser Lys Trp 
        35                  40                  45              


Met Tyr Gly Pro Pro Ser Leu Cys Leu Gly Phe Ala Ser Tyr Glu Tyr 
    50                  55                  60                  


Cys Ile Phe Asn Pro Arg Leu Phe Glu Lys Asn Leu Leu Val Ser Gly 
65                  70                  75                  80  


Pro Ala Trp Phe Lys Thr Arg Val Val Gln Gly Pro Thr Ala Tyr Val 
                85                  90                  95      


Phe Phe Ser Tyr Glu Val Glu Ser Glu Lys Trp Tyr Leu Ser Thr Asp 
            100                 105                 110         


Phe Pro Ser Thr Ser Ile Lys Thr Glu Pro Val Thr Asp Glu Pro Pro 
        115                 120                 125             


Pro Gly Leu Val Pro Ser Val Thr Leu Thr Ile Thr Ala Ile Ser Thr 
    130                 135                 140                 


Pro Leu Glu Lys Glu Glu Pro Pro Leu Glu Met Asn Thr Gly Val Asp 
145                 150                 155                 160 


Ser Ser Cys Gln Thr Ile Ile Pro Lys Ile Lys Leu Glu Pro His Glu 
                165                 170                 175     


Val Asp Gln Phe Leu Asn Phe Ser Pro Lys Glu Gly Leu Ser Ala Leu 
            180                 185                 190         


Pro Val Ser Leu Trp Val Met Asp Met Val Ser Gly Ser Thr Glu Arg 
        195                 200                 205             


Glu Tyr Gly Glu Arg Ala Gly Met Ser Leu Tyr His Arg Cys Cys Ser 
    210                 215                 220                 


Trp Leu Tyr Glu Ile Ala Leu Phe Leu Lys Asn Lys Asn Phe Ala Ser 
225                 230                 235                 240 


<210>  567
<211>  460
<212>  PRT
<213>  Homo sapiens

<400>  567

Met Glu Val Leu Glu Ser Gly Glu Gln Gly Val Leu Gln Trp Asp Arg 
1               5                   10                  15      


Lys Leu Ser Glu Leu Ser Glu Pro Gly Asp Gly Glu Ala Leu Met Tyr 
            20                  25                  30          


His Thr His Phe Ser Glu Leu Leu Asp Glu Phe Ser Gln Asn Val Leu 
        35                  40                  45              


Gly Gln Leu Leu Asn Asp Pro Phe Leu Ser Glu Lys Ser Val Ser Met 
    50                  55                  60                  


Glu Val Glu Pro Ser Pro Thr Ser Pro Ala Pro Leu Ile Gln Ala Glu 
65                  70                  75                  80  


His Ser Tyr Ser Leu Cys Glu Glu Pro Arg Ala Gln Ser Pro Phe Thr 
                85                  90                  95      


His Ile Thr Thr Ser Asp Ser Phe Asn Asp Asp Glu Val Glu Ser Glu 
            100                 105                 110         


Lys Trp Tyr Leu Ser Thr Asp Phe Pro Ser Thr Ser Ile Lys Thr Glu 
        115                 120                 125             


Pro Val Thr Asp Glu Pro Pro Pro Gly Leu Val Pro Ser Val Thr Leu 
    130                 135                 140                 


Thr Ile Thr Ala Ile Ser Thr Pro Leu Glu Lys Glu Glu Pro Pro Leu 
145                 150                 155                 160 


Glu Met Asn Thr Gly Val Asp Ser Ser Cys Gln Thr Ile Ile Pro Lys 
                165                 170                 175     


Ile Lys Leu Glu Pro His Glu Val Asp Gln Phe Leu Asn Phe Ser Pro 
            180                 185                 190         


Lys Glu Ala Pro Val Asp His Leu His Leu Pro Pro Thr Pro Pro Ser 
        195                 200                 205             


Ser His Gly Ser Asp Ser Glu Gly Ser Leu Ser Pro Asn Pro Arg Leu 
    210                 215                 220                 


His Pro Phe Ser Leu Pro Gln Thr His Ser Pro Ser Arg Ala Ala Pro 
225                 230                 235                 240 


Arg Ala Pro Ser Ala Leu Ser Ser Ser Pro Leu Leu Thr Ala Pro His 
                245                 250                 255     


Lys Leu Gln Gly Ser Gly Pro Leu Val Leu Thr Glu Glu Glu Lys Arg 
            260                 265                 270         


Thr Leu Ile Ala Glu Gly Tyr Pro Ile Pro Thr Lys Leu Pro Leu Ser 
        275                 280                 285             


Lys Ser Glu Glu Lys Ala Leu Lys Lys Ile Arg Arg Lys Ile Lys Asn 
    290                 295                 300                 


Lys Ile Ser Ala Gln Glu Ser Arg Arg Lys Lys Lys Glu Tyr Met Asp 
305                 310                 315                 320 


Ser Leu Glu Lys Lys Val Glu Ser Cys Ser Thr Glu Asn Leu Glu Leu 
                325                 330                 335     


Arg Lys Lys Val Glu Val Leu Glu Asn Thr Asn Arg Thr Leu Leu Gln 
            340                 345                 350         


Gln Leu Gln Lys Leu Gln Thr Leu Val Met Gly Lys Val Ser Arg Thr 
        355                 360                 365             


Cys Lys Leu Ala Gly Thr Gln Thr Gly Thr Cys Leu Met Val Val Val 
    370                 375                 380                 


Leu Cys Phe Ala Val Ala Phe Gly Ser Phe Phe Gln Gly Tyr Gly Pro 
385                 390                 395                 400 


Tyr Pro Ser Ala Thr Lys Met Ala Leu Pro Ser Gln His Ser Leu Gln 
                405                 410                 415     


Glu Pro Tyr Thr Ala Ser Val Gly Lys Thr Ala Cys Gly Lys Leu Gly 
            420                 425                 430         


Arg Val Leu Phe Tyr Phe Pro Arg Ala Gly Phe Leu Ser Leu Pro Lys 
        435                 440                 445             


Gly Ile Phe Cys Glu Ser Pro Met Phe Lys Lys Trp 
    450                 455                 460 


<210>  568
<211>  449
<212>  PRT
<213>  Homo sapiens

<400>  568

Met Asp Arg Val Tyr Glu Ile Pro Glu Glu Pro Asn Val Asp Pro Val 
1               5                   10                  15      


Ser Ser Leu Glu Glu Asp Val Ile Arg Gly Ala Asn Pro Arg Phe Thr 
            20                  25                  30          


Phe Pro Phe Ser Ile Leu Phe Ser Thr Phe Leu Tyr Cys Gly Glu Ala 
        35                  40                  45              


Ala Ser Ala Leu Tyr Met Val Arg Ile Tyr Arg Lys Asn Ser Glu Thr 
    50                  55                  60                  


Tyr Trp Met Thr Tyr Thr Phe Ser Phe Phe Met Phe Ser Ser Ile Met 
65                  70                  75                  80  


Val Gln Leu Thr Leu Ile Phe Val His Arg Asp Leu Ala Lys Asp Lys 
                85                  90                  95      


Pro Leu Ser Leu Phe Met His Leu Ile Leu Leu Gly Pro Val Ile Arg 
            100                 105                 110         


Cys Leu Glu Ala Met Ile Lys Tyr Leu Thr Leu Trp Lys Lys Glu Glu 
        115                 120                 125             


Gln Glu Glu Pro Tyr Val Ser Leu Thr Arg Lys Lys Met Leu Ile Asp 
    130                 135                 140                 


Gly Glu Glu Val Leu Ile Glu Trp Glu Val Gly His Ser Ile Arg Thr 
145                 150                 155                 160 


Leu Ala Met His Arg Asn Ala Tyr Lys Arg Met Ser Gln Ile Gln Ala 
                165                 170                 175     


Phe Leu Gly Ser Val Pro Gln Leu Thr Tyr Gln Leu Tyr Val Ser Leu 
            180                 185                 190         


Ile Ser Ala Glu Val Pro Leu Gly Arg Val Val Leu Met Val Phe Ser 
        195                 200                 205             


Leu Val Ser Val Thr Tyr Gly Ala Thr Leu Cys Asn Met Leu Ala Ile 
    210                 215                 220                 


Gln Ile Lys Tyr Asp Asp Tyr Lys Ile Arg Leu Gly Pro Leu Glu Val 
225                 230                 235                 240 


Leu Cys Ile Thr Ile Trp Arg Thr Leu Glu Ile Thr Ser Arg Leu Leu 
                245                 250                 255     


Ile Leu Val Leu Phe Ser Ala Thr Leu Lys Leu Lys Ala Val Pro Phe 
            260                 265                 270         


Leu Val Leu Asn Phe Leu Ile Ile Leu Phe Glu Pro Trp Ile Lys Phe 
        275                 280                 285             


Trp Arg Ser Gly Ala Gln Met Pro Asn Asn Ile Glu Lys Asn Phe Ser 
    290                 295                 300                 


Arg Val Gly Thr Leu Val Val Leu Ile Ser Val Thr Ile Leu Tyr Ala 
305                 310                 315                 320 


Gly Ile Asn Phe Ser Cys Trp Ser Ala Leu Gln Leu Arg Leu Ala Asp 
                325                 330                 335     


Arg Asp Leu Val Asp Lys Gly Gln Asn Trp Gly His Met Gly Leu His 
            340                 345                 350         


Tyr Ser Val Arg Leu Val Glu Asn Val Ile Met Val Leu Val Phe Lys 
        355                 360                 365             


Phe Phe Gly Val Lys Val Leu Leu Asn Tyr Cys His Ser Leu Ile Ala 
    370                 375                 380                 


Leu Gln Leu Ile Ile Ala Tyr Leu Ile Ser Ile Gly Phe Met Leu Leu 
385                 390                 395                 400 


Phe Phe Gln Tyr Leu His Pro Leu Arg Ser Leu Phe Thr His Asn Val 
                405                 410                 415     


Val Asp Tyr Leu His Cys Val Cys Cys His Gln His Pro Arg Thr Arg 
            420                 425                 430         


Val Glu Asn Ser Glu Pro Pro Phe Glu Thr Glu Ala Arg Gln Ser Val 
        435                 440                 445             


Val 
    


<210>  569
<211>  139
<212>  PRT
<213>  Homo sapiens

<400>  569

Met Asp Arg Val Tyr Glu Ile Pro Glu Glu Pro Asn Val Asp Pro Val 
1               5                   10                  15      


Ser Ser Leu Glu Glu Asp Val Ile Arg Gly Ala Asn Pro Arg Phe Thr 
            20                  25                  30          


Phe Pro Phe Ser Ile Leu Phe Ser Thr Phe Leu Tyr Cys Gly Glu Ala 
        35                  40                  45              


Ala Ser Ala Leu Tyr Met Val Arg Ile Tyr Arg Lys Asn Ser Glu Thr 
    50                  55                  60                  


Tyr Trp Met Thr Tyr Thr Phe Ser Phe Phe Met Phe Ser Ser Ile Met 
65                  70                  75                  80  


Val Gln Leu Thr Leu Ile Phe Val His Arg Asp Leu Ala Lys Asp Lys 
                85                  90                  95      


Pro Leu Ser Leu Phe Met His Leu Ile Leu Leu Gly Pro Val Ile Ser 
            100                 105                 110         


Cys Ala Asn Gly Ile Phe Pro Gly Ile Cys His Leu Trp Gly His Pro 
        115                 120                 125             


Leu Gln Tyr Val Gly Tyr Pro Asp Gln Val Arg 
    130                 135                 


<210>  570
<211>  471
<212>  PRT
<213>  Homo sapiens

<400>  570

Met Ala Ser Val Val Leu Pro Ser Gly Ser Gln Cys Ala Ala Ala Ala 
1               5                   10                  15      


Ala Ala Ala Ala Pro Pro Gly Leu Arg Leu Arg Leu Leu Leu Leu Leu 
            20                  25                  30          


Phe Ser Ala Ala Ala Leu Ile Pro Thr Gly Asp Gly Gln Asn Leu Phe 
        35                  40                  45              


Thr Lys Asp Val Thr Val Ile Glu Gly Glu Val Ala Thr Ile Ser Cys 
    50                  55                  60                  


Gln Val Asn Lys Ser Asp Asp Ser Val Ile Gln Leu Leu Asn Pro Asn 
65                  70                  75                  80  


Arg Gln Thr Ile Tyr Phe Arg Asp Phe Arg Pro Leu Lys Asp Ser Arg 
                85                  90                  95      


Phe Gln Leu Leu Asn Phe Ser Ser Ser Glu Leu Lys Val Ser Leu Thr 
            100                 105                 110         


Asn Val Ser Ile Ser Asp Glu Gly Arg Tyr Phe Cys Gln Leu Tyr Thr 
        115                 120                 125             


Asp Pro Pro Gln Glu Ser Tyr Thr Thr Ile Thr Val Leu Val Pro Pro 
    130                 135                 140                 


Arg Asn Leu Met Ile Asp Ile Gln Lys Asp Thr Ala Val Glu Gly Glu 
145                 150                 155                 160 


Glu Ile Glu Val Asn Cys Thr Ala Met Ala Ser Lys Pro Ala Thr Thr 
                165                 170                 175     


Ile Arg Trp Phe Lys Gly Asn Thr Glu Leu Lys Gly Lys Ser Glu Val 
            180                 185                 190         


Glu Glu Trp Ser Asp Met Tyr Thr Val Thr Ser Gln Leu Met Leu Lys 
        195                 200                 205             


Val His Lys Glu Asp Asp Gly Val Pro Val Ile Cys Gln Val Glu His 
    210                 215                 220                 


Pro Ala Val Thr Gly Asn Leu Gln Thr Gln Arg Tyr Leu Glu Val Gln 
225                 230                 235                 240 


Tyr Lys Pro Gln Val His Ile Gln Met Thr Tyr Pro Leu Gln Gly Leu 
                245                 250                 255     


Thr Arg Glu Gly Asp Ala Leu Glu Leu Thr Cys Glu Ala Ile Gly Lys 
            260                 265                 270         


Pro Gln Pro Val Met Val Thr Trp Val Arg Val Asp Asp Glu Met Pro 
        275                 280                 285             


Gln His Ala Val Leu Ser Gly Pro Asn Leu Phe Ile Asn Asn Leu Asn 
    290                 295                 300                 


Lys Thr Asp Asn Gly Thr Tyr Arg Cys Glu Ala Ser Asn Ile Val Gly 
305                 310                 315                 320 


Lys Ala His Ser Asp Tyr Met Leu Tyr Val Tyr Asp Pro Pro Thr Thr 
                325                 330                 335     


Ile Pro Pro Pro Thr Thr Thr Thr Thr Thr Thr Thr Thr Thr Thr Thr 
            340                 345                 350         


Thr Ile Leu Thr Ile Ile Thr Asp Thr Thr Ala Thr Thr Glu Pro Ala 
        355                 360                 365             


Val His Gly Leu Thr Gln Leu Pro Asn Ser Ala Glu Glu Leu Asp Ser 
    370                 375                 380                 


Glu Asp Leu Ser Asp Ser Arg Ala Gly Glu Glu Gly Ser Ile Arg Ala 
385                 390                 395                 400 


Val Asp His Ala Val Ile Gly Gly Val Val Ala Val Val Val Phe Ala 
                405                 410                 415     


Met Leu Cys Leu Leu Ile Ile Leu Gly Arg Tyr Phe Ala Arg His Lys 
            420                 425                 430         


Gly Thr Tyr Phe Thr His Glu Ala Lys Gly Ala Asp Asp Ala Ala Asp 
        435                 440                 445             


Ala Asp Thr Ala Ile Ile Asn Ala Glu Gly Gly Gln Asn Asn Ser Glu 
    450                 455                 460                 


Glu Lys Lys Glu Tyr Phe Ile 
465                 470     


<210>  571
<211>  442
<212>  PRT
<213>  Homo sapiens

<400>  571

Met Ala Ser Val Val Leu Pro Ser Gly Ser Gln Cys Ala Ala Ala Ala 
1               5                   10                  15      


Ala Ala Ala Ala Pro Pro Gly Leu Arg Leu Arg Leu Leu Leu Leu Leu 
            20                  25                  30          


Phe Ser Ala Ala Ala Leu Ile Pro Thr Gly Asp Gly Gln Asn Leu Phe 
        35                  40                  45              


Thr Lys Asp Val Thr Val Ile Glu Gly Glu Val Ala Thr Ile Ser Cys 
    50                  55                  60                  


Gln Val Asn Lys Ser Asp Asp Ser Val Ile Gln Leu Leu Asn Pro Asn 
65                  70                  75                  80  


Arg Gln Thr Ile Tyr Phe Arg Asp Phe Arg Pro Leu Lys Asp Ser Arg 
                85                  90                  95      


Phe Gln Leu Leu Asn Phe Ser Ser Ser Glu Leu Lys Val Ser Leu Thr 
            100                 105                 110         


Asn Val Ser Ile Ser Asp Glu Gly Arg Tyr Phe Cys Gln Leu Tyr Thr 
        115                 120                 125             


Asp Pro Pro Gln Glu Ser Tyr Thr Thr Ile Thr Val Leu Val Pro Pro 
    130                 135                 140                 


Arg Asn Leu Met Ile Asp Ile Gln Lys Asp Thr Ala Val Glu Gly Glu 
145                 150                 155                 160 


Glu Ile Glu Val Asn Cys Thr Ala Met Ala Ser Lys Pro Ala Thr Thr 
                165                 170                 175     


Ile Arg Trp Phe Lys Gly Asn Thr Glu Leu Lys Gly Lys Ser Glu Val 
            180                 185                 190         


Glu Glu Trp Ser Asp Met Tyr Thr Val Thr Ser Gln Leu Met Leu Lys 
        195                 200                 205             


Val His Lys Glu Asp Asp Gly Val Pro Val Ile Cys Gln Val Glu His 
    210                 215                 220                 


Pro Ala Val Thr Gly Asn Leu Gln Thr Gln Arg Tyr Leu Glu Val Gln 
225                 230                 235                 240 


Tyr Lys Pro Gln Val His Ile Gln Met Thr Tyr Pro Leu Gln Gly Leu 
                245                 250                 255     


Thr Arg Glu Gly Asp Ala Leu Glu Leu Thr Cys Glu Ala Ile Gly Lys 
            260                 265                 270         


Pro Gln Pro Val Met Val Thr Trp Val Arg Val Asp Asp Glu Met Pro 
        275                 280                 285             


Gln His Ala Val Leu Ser Gly Pro Asn Leu Phe Ile Asn Asn Leu Asn 
    290                 295                 300                 


Lys Thr Asp Asn Gly Thr Tyr Arg Cys Glu Ala Ser Asn Ile Val Gly 
305                 310                 315                 320 


Lys Ala His Ser Asp Tyr Met Leu Tyr Val Tyr Asp Pro Pro Thr Thr 
                325                 330                 335     


Ile Pro Pro Pro Thr Thr Thr Thr Thr Thr Thr Thr Thr Thr Thr Thr 
            340                 345                 350         


Thr Ile Leu Thr Ile Ile Thr Asp Ser Arg Ala Gly Glu Glu Gly Ser 
        355                 360                 365             


Ile Arg Ala Val Asp His Ala Val Ile Gly Gly Val Val Ala Val Val 
    370                 375                 380                 


Val Phe Ala Met Leu Cys Leu Leu Ile Ile Leu Gly Arg Tyr Phe Ala 
385                 390                 395                 400 


Arg His Lys Gly Thr Tyr Phe Thr His Glu Ala Lys Gly Ala Asp Asp 
                405                 410                 415     


Ala Ala Asp Ala Asp Thr Ala Ile Ile Asn Ala Glu Gly Gly Gln Asn 
            420                 425                 430         


Asn Ser Glu Glu Lys Lys Glu Tyr Phe Ile 
        435                 440         


<210>  572
<211>  443
<212>  PRT
<213>  Homo sapiens

<400>  572

Met Ala Ser Val Val Leu Pro Ser Gly Ser Gln Cys Ala Ala Ala Ala 
1               5                   10                  15      


Ala Ala Ala Ala Pro Pro Gly Leu Arg Leu Arg Leu Leu Leu Leu Leu 
            20                  25                  30          


Phe Ser Ala Ala Ala Leu Ile Pro Thr Gly Asp Gly Gln Asn Leu Phe 
        35                  40                  45              


Thr Lys Asp Val Thr Val Ile Glu Gly Glu Val Ala Thr Ile Ser Cys 
    50                  55                  60                  


Gln Val Asn Lys Ser Asp Asp Ser Val Ile Gln Leu Leu Asn Pro Asn 
65                  70                  75                  80  


Arg Gln Thr Ile Tyr Phe Arg Asp Phe Arg Pro Leu Lys Asp Ser Arg 
                85                  90                  95      


Phe Gln Leu Leu Asn Phe Ser Ser Ser Glu Leu Lys Val Ser Leu Thr 
            100                 105                 110         


Asn Val Ser Ile Ser Asp Glu Gly Arg Tyr Phe Cys Gln Leu Tyr Thr 
        115                 120                 125             


Asp Pro Pro Gln Glu Ser Tyr Thr Thr Ile Thr Val Leu Val Pro Pro 
    130                 135                 140                 


Arg Asn Leu Met Ile Asp Ile Gln Lys Asp Thr Ala Val Glu Gly Glu 
145                 150                 155                 160 


Glu Ile Glu Val Asn Cys Thr Ala Met Ala Ser Lys Pro Ala Thr Thr 
                165                 170                 175     


Ile Arg Trp Phe Lys Gly Asn Thr Glu Leu Lys Gly Lys Ser Glu Val 
            180                 185                 190         


Glu Glu Trp Ser Asp Met Tyr Thr Val Thr Ser Gln Leu Met Leu Lys 
        195                 200                 205             


Val His Lys Glu Asp Asp Gly Val Pro Val Ile Cys Gln Val Glu His 
    210                 215                 220                 


Pro Ala Val Thr Gly Asn Leu Gln Thr Gln Arg Tyr Leu Glu Val Gln 
225                 230                 235                 240 


Tyr Lys Pro Gln Val His Ile Gln Met Thr Tyr Pro Leu Gln Gly Leu 
                245                 250                 255     


Thr Arg Glu Gly Asp Ala Leu Glu Leu Thr Cys Glu Ala Ile Gly Lys 
            260                 265                 270         


Pro Gln Pro Val Met Val Thr Trp Val Arg Val Asp Asp Glu Met Pro 
        275                 280                 285             


Gln His Ala Val Leu Ser Gly Pro Asn Leu Phe Ile Asn Asn Leu Asn 
    290                 295                 300                 


Lys Thr Asp Asn Gly Thr Tyr Arg Cys Glu Ala Ser Asn Ile Val Gly 
305                 310                 315                 320 


Lys Ala His Ser Asp Tyr Met Leu Tyr Val Tyr Asp Thr Thr Ala Thr 
                325                 330                 335     


Thr Glu Pro Ala Val His Gly Leu Thr Gln Leu Pro Asn Ser Ala Glu 
            340                 345                 350         


Glu Leu Asp Ser Glu Asp Leu Ser Asp Ser Arg Ala Gly Glu Glu Gly 
        355                 360                 365             


Ser Ile Arg Ala Val Asp His Ala Val Ile Gly Gly Val Val Ala Val 
    370                 375                 380                 


Val Val Phe Ala Met Leu Cys Leu Leu Ile Ile Leu Gly Arg Tyr Phe 
385                 390                 395                 400 


Ala Arg His Lys Gly Thr Tyr Phe Thr His Glu Ala Lys Gly Ala Asp 
                405                 410                 415     


Asp Ala Ala Asp Ala Asp Thr Ala Ile Ile Asn Ala Glu Gly Gly Gln 
            420                 425                 430         


Asn Asn Ser Glu Glu Lys Lys Glu Tyr Phe Ile 
        435                 440             


<210>  573
<211>  453
<212>  PRT
<213>  Homo sapiens

<400>  573

Met Ala Ser Val Val Leu Pro Ser Gly Ser Gln Cys Ala Ala Ala Ala 
1               5                   10                  15      


Ala Ala Ala Ala Pro Pro Gly Leu Arg Leu Arg Leu Leu Leu Leu Leu 
            20                  25                  30          


Phe Ser Ala Ala Ala Leu Ile Pro Thr Gly Asp Gly Gln Asn Leu Phe 
        35                  40                  45              


Thr Lys Asp Val Thr Val Ile Glu Gly Glu Val Ala Thr Ile Ser Cys 
    50                  55                  60                  


Gln Val Asn Lys Ser Asp Asp Ser Val Ile Gln Leu Leu Asn Pro Asn 
65                  70                  75                  80  


Arg Gln Thr Ile Tyr Phe Arg Asp Phe Arg Pro Leu Lys Asp Ser Arg 
                85                  90                  95      


Phe Gln Leu Leu Asn Phe Ser Ser Ser Glu Leu Lys Val Ser Leu Thr 
            100                 105                 110         


Asn Val Ser Ile Ser Asp Glu Gly Arg Tyr Phe Cys Gln Leu Tyr Thr 
        115                 120                 125             


Asp Pro Pro Gln Glu Ser Tyr Thr Thr Ile Thr Val Leu Val Pro Pro 
    130                 135                 140                 


Arg Asn Leu Met Ile Asp Ile Gln Lys Asp Thr Ala Val Glu Gly Glu 
145                 150                 155                 160 


Glu Ile Glu Val Asn Cys Thr Ala Met Ala Ser Lys Pro Ala Thr Thr 
                165                 170                 175     


Ile Arg Trp Phe Lys Gly Asn Thr Glu Leu Lys Gly Lys Ser Glu Val 
            180                 185                 190         


Glu Glu Trp Ser Asp Met Tyr Thr Val Thr Ser Gln Leu Met Leu Lys 
        195                 200                 205             


Val His Lys Glu Asp Asp Gly Val Pro Val Ile Cys Gln Val Glu His 
    210                 215                 220                 


Pro Ala Val Thr Gly Asn Leu Gln Thr Gln Arg Tyr Leu Glu Val Gln 
225                 230                 235                 240 


Tyr Lys Pro Gln Val His Ile Gln Met Thr Tyr Pro Leu Gln Gly Leu 
                245                 250                 255     


Thr Arg Glu Gly Asp Ala Leu Glu Leu Thr Cys Glu Ala Ile Gly Lys 
            260                 265                 270         


Pro Gln Pro Val Met Val Thr Trp Val Arg Val Asp Asp Glu Met Pro 
        275                 280                 285             


Gln His Ala Val Leu Ser Gly Pro Asn Leu Phe Ile Asn Asn Leu Asn 
    290                 295                 300                 


Lys Thr Asp Asn Gly Thr Tyr Arg Cys Glu Ala Ser Asn Ile Val Gly 
305                 310                 315                 320 


Lys Ala His Ser Asp Tyr Met Leu Tyr Val Tyr Asp Pro Pro Thr Thr 
                325                 330                 335     


Ile Pro Pro Pro Thr Thr Thr Thr Thr Thr Thr Thr Thr Thr Thr Thr 
            340                 345                 350         


Thr Ile Leu Thr Ile Ile Thr Asp Thr Thr Ala Thr Thr Glu Pro Ala 
        355                 360                 365             


Val His Asp Ser Arg Ala Gly Glu Glu Gly Ser Ile Arg Ala Val Asp 
    370                 375                 380                 


His Ala Val Ile Gly Gly Val Val Ala Val Val Val Phe Ala Met Leu 
385                 390                 395                 400 


Cys Leu Leu Ile Ile Leu Gly Arg Tyr Phe Ala Arg His Lys Gly Thr 
                405                 410                 415     


Tyr Phe Thr His Glu Ala Lys Gly Ala Asp Asp Ala Ala Asp Ala Asp 
            420                 425                 430         


Thr Ala Ile Ile Asn Ala Glu Gly Gly Gln Asn Asn Ser Glu Glu Lys 
        435                 440                 445             


Lys Glu Tyr Phe Ile 
    450             


<210>  574
<211>  67
<212>  PRT
<213>  Homo sapiens

<400>  574

Met Ala Ser Val Val Leu Pro Ser Gly Ser Gln Cys Ala Ala Ala Ala 
1               5                   10                  15      


Ala Ala Ala Ala Pro Pro Gly Leu Arg Leu Arg Leu Leu Leu Leu Leu 
            20                  25                  30          


Phe Ser Ala Ala Ala Leu Ile Pro Thr Gly Leu Thr Ser Ser Pro Arg 
        35                  40                  45              


Leu Glu Cys Gly Gly Thr Ile Ser Ala His Cys Ser Leu Gly Leu Pro 
    50                  55                  60                  


Val Leu Arg 
65          


<210>  575
<211>  414
<212>  PRT
<213>  Homo sapiens

<400>  575

Met Ala Ser Val Val Leu Pro Ser Gly Ser Gln Cys Ala Ala Ala Ala 
1               5                   10                  15      


Ala Ala Ala Ala Pro Pro Gly Leu Arg Leu Arg Leu Leu Leu Leu Leu 
            20                  25                  30          


Phe Ser Ala Ala Ala Leu Ile Pro Thr Gly Asp Gly Gln Asn Leu Phe 
        35                  40                  45              


Thr Lys Asp Val Thr Val Ile Glu Gly Glu Val Ala Thr Ile Ser Cys 
    50                  55                  60                  


Gln Val Asn Lys Ser Asp Asp Ser Val Ile Gln Leu Leu Asn Pro Asn 
65                  70                  75                  80  


Arg Gln Thr Ile Tyr Phe Arg Asp Phe Arg Pro Leu Lys Asp Ser Arg 
                85                  90                  95      


Phe Gln Leu Leu Asn Phe Ser Ser Ser Glu Leu Lys Val Ser Leu Thr 
            100                 105                 110         


Asn Val Ser Ile Ser Asp Glu Gly Arg Tyr Phe Cys Gln Leu Tyr Thr 
        115                 120                 125             


Asp Pro Pro Gln Glu Ser Tyr Thr Thr Ile Thr Val Leu Val Pro Pro 
    130                 135                 140                 


Arg Asn Leu Met Ile Asp Ile Gln Lys Asp Thr Ala Val Glu Gly Glu 
145                 150                 155                 160 


Glu Ile Glu Val Asn Cys Thr Ala Met Ala Ser Lys Pro Ala Thr Thr 
                165                 170                 175     


Ile Arg Trp Phe Lys Gly Asn Thr Glu Leu Lys Gly Lys Ser Glu Val 
            180                 185                 190         


Glu Glu Trp Ser Asp Met Tyr Thr Val Thr Ser Gln Leu Met Leu Lys 
        195                 200                 205             


Val His Lys Glu Asp Asp Gly Val Pro Val Ile Cys Gln Val Glu His 
    210                 215                 220                 


Pro Ala Val Thr Gly Asn Leu Gln Thr Gln Arg Tyr Leu Glu Val Gln 
225                 230                 235                 240 


Tyr Lys Pro Gln Val His Ile Gln Met Thr Tyr Pro Leu Gln Gly Leu 
                245                 250                 255     


Thr Arg Glu Gly Asp Ala Leu Glu Leu Thr Cys Glu Ala Ile Gly Lys 
            260                 265                 270         


Pro Gln Pro Val Met Val Thr Trp Val Arg Val Asp Asp Glu Met Pro 
        275                 280                 285             


Gln His Ala Val Leu Ser Gly Pro Asn Leu Phe Ile Asn Asn Leu Asn 
    290                 295                 300                 


Lys Thr Asp Asn Gly Thr Tyr Arg Cys Glu Ala Ser Asn Ile Val Gly 
305                 310                 315                 320 


Lys Ala His Ser Asp Tyr Met Leu Tyr Val Tyr Asp Ser Arg Ala Gly 
                325                 330                 335     


Glu Glu Gly Ser Ile Arg Ala Val Asp His Ala Val Ile Gly Gly Val 
            340                 345                 350         


Val Ala Val Val Val Phe Ala Met Leu Cys Leu Leu Ile Ile Leu Gly 
        355                 360                 365             


Arg Tyr Phe Ala Arg His Lys Gly Thr Tyr Phe Thr His Glu Ala Lys 
    370                 375                 380                 


Gly Ala Asp Asp Ala Ala Asp Ala Asp Thr Ala Ile Ile Asn Ala Glu 
385                 390                 395                 400 


Gly Gly Gln Asn Asn Ser Glu Glu Lys Lys Glu Tyr Phe Ile 
                405                 410                 


<210>  576
<211>  111
<212>  PRT
<213>  Homo sapiens

<400>  576

Met Ile Asp Ile Gln Lys Asp Thr Ala Val Glu Gly Glu Glu Ile Glu 
1               5                   10                  15      


Val Asn Cys Thr Ala Met Ala Ser Lys Pro Ala Thr Thr Ile Arg Trp 
            20                  25                  30          


Phe Lys Gly Asn Thr Glu Leu Lys Gly Lys Ser Glu Val Glu Glu Trp 
        35                  40                  45              


Ser Asp Met Tyr Thr Val Thr Ser Gln Leu Met Leu Lys Val His Lys 
    50                  55                  60                  


Glu Asp Asp Gly Val Pro Val Ile Cys Gln Val Glu His Pro Ala Val 
65                  70                  75                  80  


Thr Gly Asn Leu Gln Thr Gln Arg Tyr Leu Glu Val Gln Tyr Lys Pro 
                85                  90                  95      


Gln Val His Ile Gln Met Thr Tyr Pro Leu Gln Gly Leu Thr Arg 
            100                 105                 110     


<210>  577
<211>  79
<212>  PRT
<213>  Homo sapiens

<400>  577

Met Ile Asp Ile Gln Lys Asp Thr Ala Val Glu Gly Glu Glu Ile Glu 
1               5                   10                  15      


Val Asn Cys Thr Ala Met Ala Ser Lys Pro Ala Thr Thr Ile Arg Trp 
            20                  25                  30          


Phe Lys Gly Asn Thr Glu Leu Lys Gly Lys Ser Glu Val Glu Glu Trp 
        35                  40                  45              


Ser Asp Met Tyr Thr Val Thr Ser Gln Leu Met Leu Lys Val His Lys 
    50                  55                  60                  


Glu Asp Asp Gly Val Pro Val Ile Cys Gln Val Glu His Pro Ala 
65                  70                  75                  


<210>  578
<211>  413
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  578

Xaa Ser Val Val Leu Pro Ser Gly Ser Gln Cys Ala Ala Ala Ala Ala 
1               5                   10                  15      


Ala Ala Ala Pro Pro Gly Leu Arg Leu Arg Leu Leu Leu Leu Leu Phe 
            20                  25                  30          


Ser Ala Ala Ala Leu Ile Pro Thr Gly Asp Gly Gln Asn Leu Phe Thr 
        35                  40                  45              


Lys Asp Val Thr Val Ile Glu Gly Glu Val Ala Thr Ile Ser Cys Gln 
    50                  55                  60                  


Val Asn Lys Ser Asp Asp Ser Val Ile Gln Leu Leu Asn Pro Asn Arg 
65                  70                  75                  80  


Gln Thr Ile Tyr Phe Arg Asp Phe Arg Pro Leu Lys Asp Ser Arg Phe 
                85                  90                  95      


Gln Leu Leu Asn Phe Ser Ser Ser Glu Leu Lys Val Ser Leu Thr Asn 
            100                 105                 110         


Val Ser Ile Ser Asp Glu Gly Arg Tyr Phe Cys Gln Leu Tyr Thr Asp 
        115                 120                 125             


Pro Pro Gln Glu Ser Tyr Thr Thr Ile Thr Val Leu Val Pro Pro Arg 
    130                 135                 140                 


Asn Leu Met Ile Asp Ile Gln Lys Asp Thr Ala Val Glu Gly Glu Glu 
145                 150                 155                 160 


Ile Glu Val Asn Cys Thr Ala Met Ala Ser Lys Pro Ala Thr Thr Ile 
                165                 170                 175     


Arg Trp Phe Lys Gly Asn Thr Glu Leu Lys Gly Lys Ser Glu Val Glu 
            180                 185                 190         


Glu Trp Ser Asp Met Tyr Thr Val Thr Ser Gln Leu Met Leu Lys Val 
        195                 200                 205             


His Lys Glu Asp Asp Gly Val Pro Val Ile Cys Gln Val Glu His Pro 
    210                 215                 220                 


Ala Val Thr Gly Asn Leu Gln Thr Gln Arg Tyr Leu Glu Val Gln Tyr 
225                 230                 235                 240 


Lys Pro Gln Val His Ile Gln Met Thr Tyr Pro Leu Gln Gly Leu Thr 
                245                 250                 255     


Arg Glu Gly Asp Ala Leu Glu Leu Thr Cys Glu Ala Ile Gly Lys Pro 
            260                 265                 270         


Gln Pro Val Met Val Thr Trp Val Arg Val Asp Asp Glu Met Pro Gln 
        275                 280                 285             


His Ala Val Leu Ser Gly Pro Asn Leu Phe Ile Asn Asn Leu Asn Lys 
    290                 295                 300                 


Thr Asp Asn Gly Thr Tyr Arg Cys Glu Ala Ser Asn Ile Val Gly Lys 
305                 310                 315                 320 


Ala His Ser Asp Tyr Met Leu Tyr Val Tyr Asp Ser Arg Ala Gly Glu 
                325                 330                 335     


Glu Gly Ser Ile Arg Ala Val Asp His Ala Val Ile Gly Gly Val Val 
            340                 345                 350         


Ala Val Val Val Phe Ala Met Leu Cys Leu Leu Ile Ile Leu Gly Arg 
        355                 360                 365             


Tyr Phe Ala Arg His Lys Gly Thr Tyr Phe Thr His Glu Ala Lys Gly 
    370                 375                 380                 


Ala Asp Asp Ala Ala Asp Ala Asp Thr Ala Ile Ile Asn Ala Glu Gly 
385                 390                 395                 400 


Gly Gln Asn Asn Ser Glu Glu Lys Lys Glu Tyr Phe Ile 
                405                 410             


<210>  579
<211>  346
<212>  PRT
<213>  Homo sapiens

<400>  579

Gly Asp Gly Gln Asn Leu Phe Thr Lys Asp Val Thr Val Ile Glu Gly 
1               5                   10                  15      


Glu Val Ala Thr Ile Ser Cys Gln Val Asn Lys Ser Asp Asp Ser Val 
            20                  25                  30          


Ile Gln Leu Leu Asn Pro Asn Arg Gln Thr Ile Tyr Phe Arg Asp Phe 
        35                  40                  45              


Arg Pro Leu Lys Asp Ser Arg Phe Gln Leu Leu Asn Phe Ser Ser Ser 
    50                  55                  60                  


Glu Leu Lys Val Ser Leu Thr Asn Val Ser Ile Ser Asp Glu Gly Arg 
65                  70                  75                  80  


Tyr Phe Cys Gln Leu Tyr Thr Asp Pro Pro Gln Glu Ser Tyr Thr Thr 
                85                  90                  95      


Ile Thr Val Leu Val Pro Pro Arg Asn Leu Met Ile Asp Ile Gln Lys 
            100                 105                 110         


Asp Thr Ala Val Glu Gly Glu Glu Ile Glu Val Asn Cys Thr Ala Met 
        115                 120                 125             


Ala Ser Lys Pro Ala Thr Thr Ile Arg Trp Phe Lys Gly Asn Thr Glu 
    130                 135                 140                 


Leu Lys Gly Lys Ser Glu Val Glu Glu Trp Ser Asp Met Tyr Thr Val 
145                 150                 155                 160 


Thr Ser Gln Leu Met Leu Lys Val His Lys Glu Asp Asp Gly Val Pro 
                165                 170                 175     


Val Ile Cys Gln Val Glu His Pro Ala Val Thr Gly Asn Leu Gln Thr 
            180                 185                 190         


Gln Arg Tyr Leu Glu Val Gln Tyr Lys Pro Gln Val His Ile Gln Met 
        195                 200                 205             


Thr Tyr Pro Leu Gln Gly Leu Thr Arg Glu Gly Asp Ala Leu Glu Leu 
    210                 215                 220                 


Thr Cys Glu Ala Ile Gly Lys Pro Gln Pro Val Met Val Thr Trp Val 
225                 230                 235                 240 


Arg Val Asp Asp Glu Met Pro Gln His Ala Val Leu Ser Gly Pro Asn 
                245                 250                 255     


Leu Phe Ile Asn Asn Leu Asn Lys Thr Asp Asn Gly Thr Tyr Arg Cys 
            260                 265                 270         


Glu Ala Ser Asn Ile Val Gly Lys Ala His Ser Asp Tyr Met Leu Tyr 
        275                 280                 285             


Val Tyr Asp Ser Arg Ala Gly Glu Glu Gly Ser Ile Arg Ala Val Asp 
    290                 295                 300                 


His Ala Val Ile Gly Gly Val Val Ala Val Val Val Phe Ala Met Leu 
305                 310                 315                 320 


Cys Leu Leu Ile Ile Leu Gly Arg Tyr Phe Ala Arg His Lys Gly Leu 
                325                 330                 335     


Phe Ser Leu Thr Ser Ser Pro Arg Ile Lys 
            340                 345     


<210>  580
<211>  373
<212>  PRT
<213>  Homo sapiens

<400>  580

Gly Asp Gly Gln Asn Leu Phe Thr Lys Asp Val Thr Val Ile Glu Gly 
1               5                   10                  15      


Glu Val Ala Thr Ile Ser Cys Gln Val Asn Lys Ser Asp Asp Ser Val 
            20                  25                  30          


Ile Gln Leu Leu Asn Pro Asn Arg Gln Thr Ile Tyr Phe Arg Asp Phe 
        35                  40                  45              


Arg Pro Leu Lys Asp Ser Arg Phe Gln Leu Leu Asn Phe Ser Ser Ser 
    50                  55                  60                  


Glu Leu Lys Val Ser Leu Thr Asn Val Ser Ile Ser Asp Glu Gly Arg 
65                  70                  75                  80  


Tyr Phe Cys Gln Leu Tyr Thr Asp Pro Pro Gln Glu Ser Tyr Thr Thr 
                85                  90                  95      


Ile Thr Val Leu Val Pro Pro Arg Asn Leu Met Ile Asp Ile Gln Lys 
            100                 105                 110         


Asp Thr Ala Val Glu Gly Glu Glu Ile Glu Val Asn Cys Thr Ala Met 
        115                 120                 125             


Ala Ser Lys Pro Ala Thr Thr Ile Arg Trp Phe Lys Gly Asn Thr Glu 
    130                 135                 140                 


Leu Lys Gly Lys Ser Glu Val Glu Glu Trp Ser Asp Met Tyr Thr Val 
145                 150                 155                 160 


Thr Ser Gln Leu Met Leu Lys Val His Lys Glu Asp Asp Gly Val Pro 
                165                 170                 175     


Val Ile Cys Gln Val Glu His Pro Ala Val Thr Gly Asn Leu Gln Thr 
            180                 185                 190         


Gln Arg Tyr Leu Glu Val Gln Tyr Lys Pro Gln Val His Ile Gln Met 
        195                 200                 205             


Thr Tyr Pro Leu Gln Gly Leu Thr Arg Glu Gly Asp Ala Leu Glu Leu 
    210                 215                 220                 


Thr Cys Glu Ala Ile Gly Lys Pro Gln Pro Val Met Val Thr Trp Val 
225                 230                 235                 240 


Arg Val Asp Asp Glu Met Pro Gln His Ala Val Leu Ser Gly Pro Asn 
                245                 250                 255     


Leu Phe Ile Asn Asn Leu Asn Lys Thr Asp Asn Gly Thr Tyr Arg Cys 
            260                 265                 270         


Glu Ala Ser Asn Ile Val Gly Lys Ala His Ser Asp Tyr Met Leu Tyr 
        275                 280                 285             


Val Tyr Asp Ser Arg Ala Gly Glu Glu Gly Ser Ile Arg Ala Val Asp 
    290                 295                 300                 


His Ala Val Ile Gly Gly Val Val Ala Val Val Val Phe Ala Met Leu 
305                 310                 315                 320 


Cys Leu Leu Ile Ile Leu Gly Arg Tyr Phe Ala Arg His Lys Gly Thr 
                325                 330                 335     


Tyr Phe Thr His Glu Ala Lys Gly Ala Asp Asp Ala Ala Asp Ala Asp 
            340                 345                 350         


Thr Ala Ile Ile Asn Ala Glu Gly Gly Gln Asn Asn Ser Glu Glu Lys 
        355                 360                 365             


Lys Glu Tyr Phe Ile 
    370             


<210>  581
<211>  412
<212>  PRT
<213>  Homo sapiens

<400>  581

Gly Asp Gly Gln Asn Leu Phe Thr Lys Asp Val Thr Val Ile Glu Gly 
1               5                   10                  15      


Glu Val Ala Thr Ile Ser Cys Gln Val Asn Lys Ser Asp Asp Ser Val 
            20                  25                  30          


Ile Gln Leu Leu Asn Pro Asn Arg Gln Thr Ile Tyr Phe Arg Asp Phe 
        35                  40                  45              


Arg Pro Leu Lys Asp Ser Arg Phe Gln Leu Leu Asn Phe Ser Ser Ser 
    50                  55                  60                  


Glu Leu Lys Val Ser Leu Thr Asn Val Ser Ile Ser Asp Glu Gly Arg 
65                  70                  75                  80  


Tyr Phe Cys Gln Leu Tyr Thr Asp Pro Pro Gln Glu Ser Tyr Thr Thr 
                85                  90                  95      


Ile Thr Val Leu Val Pro Pro Arg Asn Leu Met Ile Asp Ile Gln Lys 
            100                 105                 110         


Asp Thr Ala Val Glu Gly Glu Glu Ile Glu Val Asn Cys Thr Ala Met 
        115                 120                 125             


Ala Ser Lys Pro Ala Thr Thr Ile Arg Trp Phe Lys Gly Asn Thr Glu 
    130                 135                 140                 


Leu Lys Gly Lys Ser Glu Val Glu Glu Trp Ser Asp Met Tyr Thr Val 
145                 150                 155                 160 


Thr Ser Gln Leu Met Leu Lys Val His Lys Glu Asp Asp Gly Val Pro 
                165                 170                 175     


Val Ile Cys Gln Val Glu His Pro Ala Val Thr Gly Asn Leu Gln Thr 
            180                 185                 190         


Gln Arg Tyr Leu Glu Val Gln Tyr Lys Pro Gln Val His Ile Gln Met 
        195                 200                 205             


Thr Tyr Pro Leu Gln Gly Leu Thr Arg Glu Gly Asp Ala Leu Glu Leu 
    210                 215                 220                 


Thr Cys Glu Ala Ile Gly Lys Pro Gln Pro Val Met Val Thr Trp Val 
225                 230                 235                 240 


Arg Val Asp Asp Glu Met Pro Gln His Ala Val Leu Ser Gly Pro Asn 
                245                 250                 255     


Leu Phe Ile Asn Asn Leu Asn Lys Thr Asp Asn Gly Thr Tyr Arg Cys 
            260                 265                 270         


Glu Ala Ser Asn Ile Val Gly Lys Ala His Ser Asp Tyr Met Leu Tyr 
        275                 280                 285             


Val Tyr Asp Pro Pro Thr Thr Ile Pro Pro Pro Thr Thr Thr Thr Thr 
    290                 295                 300                 


Thr Thr Thr Thr Thr Thr Thr Thr Ile Leu Thr Ile Ile Thr Asp Thr 
305                 310                 315                 320 


Thr Ala Thr Thr Glu Pro Ala Val His Asp Ser Arg Ala Gly Glu Glu 
                325                 330                 335     


Gly Ser Ile Arg Ala Val Asp His Ala Val Ile Gly Gly Val Val Ala 
            340                 345                 350         


Val Val Val Phe Ala Met Leu Cys Leu Leu Ile Ile Leu Gly Arg Tyr 
        355                 360                 365             


Phe Ala Arg His Lys Gly Thr Tyr Phe Thr His Glu Ala Lys Gly Ala 
    370                 375                 380                 


Asp Asp Ala Ala Asp Ala Asp Thr Ala Ile Ile Asn Ala Glu Gly Gly 
385                 390                 395                 400 


Gln Asn Asn Ser Glu Glu Lys Lys Glu Tyr Phe Ile 
                405                 410         


<210>  582
<211>  430
<212>  PRT
<213>  Homo sapiens

<400>  582

Gly Asp Gly Gln Asn Leu Phe Thr Lys Asp Val Thr Val Ile Glu Gly 
1               5                   10                  15      


Glu Val Ala Thr Ile Ser Cys Gln Val Asn Lys Ser Asp Asp Ser Val 
            20                  25                  30          


Ile Gln Leu Leu Asn Pro Asn Arg Gln Thr Ile Tyr Phe Arg Asp Phe 
        35                  40                  45              


Arg Pro Leu Lys Asp Ser Arg Phe Gln Leu Leu Asn Phe Ser Ser Ser 
    50                  55                  60                  


Glu Leu Lys Val Ser Leu Thr Asn Val Ser Ile Ser Asp Glu Gly Arg 
65                  70                  75                  80  


Tyr Phe Cys Gln Leu Tyr Thr Asp Pro Pro Gln Glu Ser Tyr Thr Thr 
                85                  90                  95      


Ile Thr Val Leu Val Pro Pro Arg Asn Leu Met Ile Asp Ile Gln Lys 
            100                 105                 110         


Asp Thr Ala Val Glu Gly Glu Glu Ile Glu Val Asn Cys Thr Ala Met 
        115                 120                 125             


Ala Ser Lys Pro Ala Thr Thr Ile Arg Trp Phe Lys Gly Asn Thr Glu 
    130                 135                 140                 


Leu Lys Gly Lys Ser Glu Val Glu Glu Trp Ser Asp Met Tyr Thr Val 
145                 150                 155                 160 


Thr Ser Gln Leu Met Leu Lys Val His Lys Glu Asp Asp Gly Val Pro 
                165                 170                 175     


Val Ile Cys Gln Val Glu His Pro Ala Val Thr Gly Asn Leu Gln Thr 
            180                 185                 190         


Gln Arg Tyr Leu Glu Val Gln Tyr Lys Pro Gln Val His Ile Gln Met 
        195                 200                 205             


Thr Tyr Pro Leu Gln Gly Leu Thr Arg Glu Gly Asp Ala Leu Glu Leu 
    210                 215                 220                 


Thr Cys Glu Ala Ile Gly Lys Pro Gln Pro Val Met Val Thr Trp Val 
225                 230                 235                 240 


Arg Val Asp Asp Glu Met Pro Gln His Ala Val Leu Ser Gly Pro Asn 
                245                 250                 255     


Leu Phe Ile Asn Asn Leu Asn Lys Thr Asp Asn Gly Thr Tyr Arg Cys 
            260                 265                 270         


Glu Ala Ser Asn Ile Val Gly Lys Ala His Ser Asp Tyr Met Leu Tyr 
        275                 280                 285             


Val Tyr Asp Pro Pro Thr Thr Ile Pro Pro Pro Thr Thr Thr Thr Thr 
    290                 295                 300                 


Thr Thr Thr Thr Thr Thr Thr Thr Ile Leu Thr Ile Ile Thr Asp Thr 
305                 310                 315                 320 


Thr Ala Thr Thr Glu Pro Ala Val His Gly Leu Thr Gln Leu Pro Asn 
                325                 330                 335     


Ser Ala Glu Glu Leu Asp Ser Glu Asp Leu Ser Asp Ser Arg Ala Gly 
            340                 345                 350         


Glu Glu Gly Ser Ile Arg Ala Val Asp His Ala Val Ile Gly Gly Val 
        355                 360                 365             


Val Ala Val Val Val Phe Ala Met Leu Cys Leu Leu Ile Ile Leu Gly 
    370                 375                 380                 


Arg Tyr Phe Ala Arg His Lys Gly Thr Tyr Phe Thr His Glu Ala Lys 
385                 390                 395                 400 


Gly Ala Asp Asp Ala Ala Asp Ala Asp Thr Ala Ile Ile Asn Ala Glu 
                405                 410                 415     


Gly Gly Gln Asn Asn Ser Glu Glu Lys Lys Glu Tyr Phe Ile 
            420                 425                 430 


<210>  583
<211>  401
<212>  PRT
<213>  Homo sapiens

<400>  583

Gly Asp Gly Gln Asn Leu Phe Thr Lys Asp Val Thr Val Ile Glu Gly 
1               5                   10                  15      


Glu Val Ala Thr Ile Ser Cys Gln Val Asn Lys Ser Asp Asp Ser Val 
            20                  25                  30          


Ile Gln Leu Leu Asn Pro Asn Arg Gln Thr Ile Tyr Phe Arg Asp Phe 
        35                  40                  45              


Arg Pro Leu Lys Asp Ser Arg Phe Gln Leu Leu Asn Phe Ser Ser Ser 
    50                  55                  60                  


Glu Leu Lys Val Ser Leu Thr Asn Val Ser Ile Ser Asp Glu Gly Arg 
65                  70                  75                  80  


Tyr Phe Cys Gln Leu Tyr Thr Asp Pro Pro Gln Glu Ser Tyr Thr Thr 
                85                  90                  95      


Ile Thr Val Leu Val Pro Pro Arg Asn Leu Met Ile Asp Ile Gln Lys 
            100                 105                 110         


Asp Thr Ala Val Glu Gly Glu Glu Ile Glu Val Asn Cys Thr Ala Met 
        115                 120                 125             


Ala Ser Lys Pro Ala Thr Thr Ile Arg Trp Phe Lys Gly Asn Thr Glu 
    130                 135                 140                 


Leu Lys Gly Lys Ser Glu Val Glu Glu Trp Ser Asp Met Tyr Thr Val 
145                 150                 155                 160 


Thr Ser Gln Leu Met Leu Lys Val His Lys Glu Asp Asp Gly Val Pro 
                165                 170                 175     


Val Ile Cys Gln Val Glu His Pro Ala Val Thr Gly Asn Leu Gln Thr 
            180                 185                 190         


Gln Arg Tyr Leu Glu Val Gln Tyr Lys Pro Gln Val His Ile Gln Met 
        195                 200                 205             


Thr Tyr Pro Leu Gln Gly Leu Thr Arg Glu Gly Asp Ala Leu Glu Leu 
    210                 215                 220                 


Thr Cys Glu Ala Ile Gly Lys Pro Gln Pro Val Met Val Thr Trp Val 
225                 230                 235                 240 


Arg Val Asp Asp Glu Met Pro Gln His Ala Val Leu Ser Gly Pro Asn 
                245                 250                 255     


Leu Phe Ile Asn Asn Leu Asn Lys Thr Asp Asn Gly Thr Tyr Arg Cys 
            260                 265                 270         


Glu Ala Ser Asn Ile Val Gly Lys Ala His Ser Asp Tyr Met Leu Tyr 
        275                 280                 285             


Val Tyr Asp Pro Pro Thr Thr Ile Pro Pro Pro Thr Thr Thr Thr Thr 
    290                 295                 300                 


Thr Thr Thr Thr Thr Thr Thr Thr Ile Leu Thr Ile Ile Thr Asp Ser 
305                 310                 315                 320 


Arg Ala Gly Glu Glu Gly Ser Ile Arg Ala Val Asp His Ala Val Ile 
                325                 330                 335     


Gly Gly Val Val Ala Val Val Val Phe Ala Met Leu Cys Leu Leu Ile 
            340                 345                 350         


Ile Leu Gly Arg Tyr Phe Ala Arg His Lys Gly Thr Tyr Phe Thr His 
        355                 360                 365             


Glu Ala Lys Gly Ala Asp Asp Ala Ala Asp Ala Asp Thr Ala Ile Ile 
    370                 375                 380                 


Asn Ala Glu Gly Gly Gln Asn Asn Ser Glu Glu Lys Lys Glu Tyr Phe 
385                 390                 395                 400 


Ile 
    


<210>  584
<211>  200
<212>  PRT
<213>  Homo sapiens

<400>  584

Met Ala Ser Ser Leu Thr Cys Thr Gly Val Ile Trp Ala Leu Leu Ser 
1               5                   10                  15      


Phe Leu Cys Ala Ala Thr Ser Cys Val Gly Phe Phe Met Pro Tyr Trp 
            20                  25                  30          


Leu Trp Gly Ser Gln Leu Gly Lys Pro Val Ser Phe Gly Thr Phe Arg 
        35                  40                  45              


Arg Cys Ser Tyr Pro Val His Asp Glu Ser Arg Gln Met Met Val Met 
    50                  55                  60                  


Val Glu Glu Cys Gly Arg Tyr Ala Ser Phe Gln Gly Ile Pro Ser Ala 
65                  70                  75                  80  


Glu Trp Arg Ile Cys Thr Ile Val Thr Gly Leu Gly Cys Gly Leu Leu 
                85                  90                  95      


Leu Leu Val Ala Leu Thr Ala Leu Met Gly Cys Cys Val Ser Asp Leu 
            100                 105                 110         


Ile Ser Arg Thr Val Gly Arg Val Ala Gly Gly Ile Gln Phe Leu Gly 
        115                 120                 125             


Gly Leu Leu Ile Gly Ala Gly Cys Ala Leu Tyr Pro Leu Gly Trp Asp 
    130                 135                 140                 


Ser Glu Glu Val Arg Gln Thr Cys Gly Tyr Thr Ser Gly Gln Phe Asp 
145                 150                 155                 160 


Leu Gly Lys Cys Glu Ile Gly Trp Ala Tyr Tyr Cys Thr Gly Ala Gly 
                165                 170                 175     


Ala Thr Ala Ala Met Leu Leu Cys Thr Trp Leu Ala Cys Phe Ser Gly 
            180                 185                 190         


Lys Lys Gln Lys His Tyr Pro Tyr 
        195                 200 


<210>  585
<211>  554
<212>  PRT
<213>  Homo sapiens

<400>  585

Met Thr Ala Pro Gly Ala Ala Gly Arg Cys Pro Pro Thr Thr Trp Leu 
1               5                   10                  15      


Gly Ser Leu Leu Leu Leu Val Cys Leu Leu Ala Ser Arg Ser Ile Thr 
            20                  25                  30          


Glu Glu Val Ser Glu Tyr Cys Ser His Met Ile Gly Ser Gly His Leu 
        35                  40                  45              


Gln Ser Leu Gln Arg Leu Ile Asp Ser Gln Met Glu Thr Ser Cys Gln 
    50                  55                  60                  


Ile Thr Phe Glu Phe Val Asp Gln Glu Gln Leu Lys Asp Pro Val Cys 
65                  70                  75                  80  


Tyr Leu Lys Lys Ala Phe Leu Leu Val Gln Asp Ile Met Glu Asp Thr 
                85                  90                  95      


Met Arg Phe Arg Asp Asn Thr Pro Asn Ala Ile Ala Ile Val Gln Leu 
            100                 105                 110         


Gln Glu Leu Ser Leu Arg Leu Lys Ser Cys Phe Thr Lys Asp Tyr Glu 
        115                 120                 125             


Glu His Asp Lys Ala Cys Val Arg Thr Phe Tyr Glu Thr Pro Leu Gln 
    130                 135                 140                 


Leu Leu Glu Lys Val Lys Asn Val Phe Asn Glu Thr Lys Asn Leu Leu 
145                 150                 155                 160 


Asp Lys Asp Trp Asn Ile Phe Ser Lys Asn Cys Asn Asn Ser Phe Ala 
                165                 170                 175     


Glu Cys Ser Ser Gln Asp Val Val Thr Lys Pro Asp Cys Asn Cys Leu 
            180                 185                 190         


Tyr Pro Lys Ala Ile Pro Ser Ser Asp Pro Ala Ser Val Ser Pro His 
        195                 200                 205             


Gln Pro Leu Ala Pro Ser Met Ala Pro Val Ala Gly Leu Thr Trp Glu 
    210                 215                 220                 


Asp Ser Glu Gly Thr Glu Gly Ser Ser Leu Leu Pro Gly Glu Gln Pro 
225                 230                 235                 240 


Leu His Thr Val Asp Pro Gly Ser Ala Lys Gln Arg Pro Pro Arg Ser 
                245                 250                 255     


Thr Cys Gln Ser Phe Glu Pro Pro Glu Thr Pro Val Val Lys Asp Ser 
            260                 265                 270         


Thr Ile Gly Gly Ser Pro Gln Pro Arg Pro Ser Val Gly Ala Phe Asn 
        275                 280                 285             


Pro Gly Met Glu Asp Ile Leu Asp Ser Ala Met Gly Thr Asn Trp Val 
    290                 295                 300                 


Pro Glu Glu Ala Ser Gly Glu Ala Ser Glu Ile Pro Val Pro Gln Gly 
305                 310                 315                 320 


Thr Glu Leu Ser Pro Ser Arg Pro Gly Gly Gly Ser Met Gln Thr Glu 
                325                 330                 335     


Pro Ala Arg Pro Ser Asn Phe Leu Ser Ala Ser Ser Pro Leu Pro Ala 
            340                 345                 350         


Ser Ala Lys Gly Gln Gln Pro Ala Asp Val Thr Gly Thr Ala Leu Pro 
        355                 360                 365             


Arg Val Gly Pro Val Arg Pro Thr Gly Gln Asp Trp Asn His Thr Pro 
    370                 375                 380                 


Gln Lys Thr Asp His Pro Ser Ala Leu Leu Arg Asp Pro Pro Glu Pro 
385                 390                 395                 400 


Gly Ser Pro Arg Ile Ser Ser Leu Arg Pro Gln Gly Leu Ser Asn Pro 
                405                 410                 415     


Ser Thr Leu Ser Ala Gln Pro Gln Leu Ser Arg Ser His Ser Ser Gly 
            420                 425                 430         


Ser Val Leu Pro Leu Gly Glu Leu Glu Gly Arg Arg Ser Thr Arg Asp 
        435                 440                 445             


Arg Arg Ser Pro Ala Glu Pro Glu Gly Gly Pro Ala Ser Glu Gly Ala 
    450                 455                 460                 


Ala Arg Pro Leu Pro Arg Phe Asn Ser Val Pro Leu Thr Asp Thr Gly 
465                 470                 475                 480 


His Glu Arg Gln Ser Glu Gly Ser Phe Ser Pro Gln Leu Gln Glu Ser 
                485                 490                 495     


Val Phe His Leu Leu Val Pro Ser Val Ile Leu Val Leu Leu Ala Val 
            500                 505                 510         


Gly Gly Leu Leu Phe Tyr Arg Trp Arg Arg Arg Ser His Gln Glu Pro 
        515                 520                 525             


Gln Arg Ala Asp Ser Pro Leu Glu Gln Pro Glu Gly Ser Pro Leu Thr 
    530                 535                 540                 


Gln Asp Asp Arg Gln Val Glu Leu Pro Val 
545                 550                 


<210>  586
<211>  119
<212>  PRT
<213>  Homo sapiens

<400>  586

Met Thr Ala Pro Gly Ala Ala Gly Arg Cys Pro Pro Thr Thr Trp Leu 
1               5                   10                  15      


Gly Ser Leu Leu Leu Leu Val Cys Leu Leu Ala Ser Arg Ser Ile Thr 
            20                  25                  30          


Glu Glu Val Ser Glu Tyr Cys Ser His Met Ile Gly Ser Gly His Leu 
        35                  40                  45              


Gln Ser Leu Gln Arg Leu Ile Asp Ser Gln Met Glu Thr Ser Cys Gln 
    50                  55                  60                  


Ile Thr Phe Glu Phe Val Asp Gln Glu Gln Leu Lys Asp Pro Val Cys 
65                  70                  75                  80  


Tyr Leu Lys Lys Ala Phe Leu Leu Val Gln Asp Ile Met Glu Asp Thr 
                85                  90                  95      


Met Arg Phe Arg Asp Asn Thr Pro Asn Ala Ile Ala Ile Val Gln Leu 
            100                 105                 110         


Gln Glu Leu Ser Leu Arg Leu 
        115                 


<210>  587
<211>  438
<212>  PRT
<213>  Homo sapiens

<400>  587

Met Thr Ala Pro Gly Ala Ala Gly Arg Cys Pro Pro Thr Thr Trp Leu 
1               5                   10                  15      


Gly Ser Leu Leu Leu Leu Val Cys Leu Leu Ala Ser Arg Ser Ile Thr 
            20                  25                  30          


Glu Glu Val Ser Glu Tyr Cys Ser His Met Ile Gly Ser Gly His Leu 
        35                  40                  45              


Gln Ser Leu Gln Arg Leu Ile Asp Ser Gln Met Glu Thr Ser Cys Gln 
    50                  55                  60                  


Ile Thr Phe Glu Phe Val Asp Gln Glu Gln Leu Lys Asp Pro Val Cys 
65                  70                  75                  80  


Tyr Leu Lys Lys Ala Phe Leu Leu Val Gln Asp Ile Met Glu Asp Thr 
                85                  90                  95      


Met Arg Phe Arg Asp Asn Thr Pro Asn Ala Ile Ala Ile Val Gln Leu 
            100                 105                 110         


Gln Glu Leu Ser Leu Arg Leu Lys Ser Cys Phe Thr Lys Asp Tyr Glu 
        115                 120                 125             


Glu His Asp Lys Ala Cys Val Arg Thr Phe Tyr Glu Thr Pro Leu Gln 
    130                 135                 140                 


Leu Leu Glu Lys Val Lys Asn Val Phe Asn Glu Thr Lys Asn Leu Leu 
145                 150                 155                 160 


Asp Lys Asp Trp Asn Ile Phe Ser Lys Asn Cys Asn Asn Ser Phe Ala 
                165                 170                 175     


Glu Cys Ser Ser Gln Asp Val Val Thr Lys Pro Asp Cys Asn Cys Leu 
            180                 185                 190         


Tyr Pro Lys Ala Ile Pro Ser Ser Asp Pro Ala Ser Val Ser Pro His 
        195                 200                 205             


Gln Pro Leu Ala Pro Ser Met Ala Pro Val Ala Gly Leu Thr Trp Glu 
    210                 215                 220                 


Asp Ser Glu Gly Thr Glu Gly Ser Ser Leu Leu Pro Gly Glu Gln Pro 
225                 230                 235                 240 


Leu His Thr Val Asp Pro Gly Ser Ala Lys Gln Arg Pro Pro Arg Ser 
                245                 250                 255     


Thr Cys Gln Ser Phe Glu Pro Pro Glu Thr Pro Val Val Lys Asp Ser 
            260                 265                 270         


Thr Ile Gly Gly Ser Pro Gln Pro Arg Pro Ser Val Gly Ala Phe Asn 
        275                 280                 285             


Pro Gly Met Glu Asp Ile Leu Asp Ser Ala Met Gly Thr Asn Trp Val 
    290                 295                 300                 


Pro Glu Glu Ala Ser Gly Glu Ala Ser Glu Ile Pro Val Pro Gln Gly 
305                 310                 315                 320 


Thr Glu Leu Ser Pro Ser Arg Pro Gly Gly Gly Ser Met Gln Thr Glu 
                325                 330                 335     


Pro Ala Arg Pro Ser Asn Phe Leu Ser Ala Ser Ser Pro Leu Pro Ala 
            340                 345                 350         


Ser Ala Lys Gly Gln Gln Pro Ala Asp Val Thr Gly His Glu Arg Gln 
        355                 360                 365             


Ser Glu Gly Ser Phe Ser Pro Gln Leu Gln Glu Ser Val Phe His Leu 
    370                 375                 380                 


Leu Val Pro Ser Val Ile Leu Val Leu Leu Ala Val Gly Gly Leu Leu 
385                 390                 395                 400 


Phe Tyr Arg Trp Arg Arg Arg Ser His Gln Glu Pro Gln Arg Ala Asp 
                405                 410                 415     


Ser Pro Leu Glu Gln Pro Glu Gly Ser Pro Leu Thr Gln Asp Asp Arg 
            420                 425                 430         


Gln Val Glu Leu Pro Val 
        435             


<210>  588
<211>  554
<212>  PRT
<213>  Homo sapiens

<400>  588

Met Thr Ala Pro Gly Ala Ala Gly Arg Cys Pro Pro Thr Thr Trp Leu 
1               5                   10                  15      


Gly Ser Leu Leu Leu Leu Val Cys Leu Leu Ala Ser Arg Ser Ile Thr 
            20                  25                  30          


Glu Glu Val Ser Glu Tyr Cys Ser His Met Ile Gly Ser Gly His Leu 
        35                  40                  45              


Gln Ser Leu Gln Arg Leu Ile Asp Ser Gln Met Glu Thr Ser Cys Gln 
    50                  55                  60                  


Ile Thr Phe Glu Phe Val Asp Gln Glu Gln Leu Lys Asp Pro Val Cys 
65                  70                  75                  80  


Tyr Leu Lys Lys Ala Phe Leu Leu Val Gln Asp Ile Met Glu Asp Thr 
                85                  90                  95      


Met Arg Phe Arg Asp Asn Thr Pro Asn Ala Ile Ala Ile Val Gln Leu 
            100                 105                 110         


Gln Glu Leu Ser Leu Arg Leu Lys Ser Cys Phe Thr Lys Asp Tyr Glu 
        115                 120                 125             


Glu His Asp Lys Ala Cys Val Arg Thr Phe Tyr Glu Thr Pro Leu Gln 
    130                 135                 140                 


Leu Leu Glu Lys Val Lys Asn Val Phe Asn Glu Thr Lys Asn Leu Leu 
145                 150                 155                 160 


Asp Lys Asp Trp Asn Ile Phe Ser Lys Asn Cys Asn Asn Ser Phe Ala 
                165                 170                 175     


Glu Cys Ser Ser Gln Asp Val Val Thr Lys Pro Asp Cys Asn Cys Leu 
            180                 185                 190         


Tyr Pro Lys Ala Ile Pro Ser Ser Asp Pro Ala Ser Val Ser Pro His 
        195                 200                 205             


Gln Pro Leu Ala Pro Ser Met Ala Pro Val Ala Gly Leu Thr Trp Glu 
    210                 215                 220                 


Asp Ser Glu Gly Thr Glu Gly Ser Ser Leu Leu Pro Gly Glu Gln Pro 
225                 230                 235                 240 


Leu His Thr Val Asp Pro Gly Ser Ala Lys Gln Arg Pro Pro Arg Ser 
                245                 250                 255     


Thr Cys Gln Ser Phe Glu Pro Pro Glu Thr Pro Val Val Lys Asp Ser 
            260                 265                 270         


Thr Ile Gly Gly Ser Pro Gln Pro Arg Pro Ser Val Gly Ala Phe Asn 
        275                 280                 285             


Pro Gly Met Glu Asp Ile Leu Asp Ser Ala Met Gly Thr Asn Trp Val 
    290                 295                 300                 


Pro Glu Glu Ala Ser Gly Glu Ala Ser Glu Ile Pro Val Pro Gln Gly 
305                 310                 315                 320 


Thr Glu Leu Ser Pro Ser Arg Pro Gly Gly Gly Ser Met Gln Thr Glu 
                325                 330                 335     


Pro Ala Arg Pro Ser Asn Phe Leu Ser Ala Ser Ser Pro Leu Pro Ala 
            340                 345                 350         


Ser Ala Lys Gly Gln Gln Pro Ala Asp Val Thr Gly Thr Ala Leu Pro 
        355                 360                 365             


Arg Val Gly Pro Val Arg Pro Thr Gly Gln Asp Trp Asn His Thr Pro 
    370                 375                 380                 


Gln Lys Thr Asp His Pro Ser Ala Leu Leu Arg Asp Pro Pro Glu Pro 
385                 390                 395                 400 


Gly Ser Pro Arg Ile Ser Ser Leu Arg Pro Gln Gly Leu Ser Asn Pro 
                405                 410                 415     


Ser Thr Leu Ser Ala Gln Pro Gln Leu Ser Arg Ser His Ser Ser Gly 
            420                 425                 430         


Ser Val Leu Pro Leu Gly Glu Leu Glu Gly Arg Arg Ser Thr Arg Asp 
        435                 440                 445             


Arg Arg Ser Pro Ala Glu Pro Glu Gly Gly Pro Ala Ser Glu Gly Ala 
    450                 455                 460                 


Ala Arg Pro Leu Pro Arg Phe Asn Ser Val Pro Leu Thr Asp Thr Gly 
465                 470                 475                 480 


His Glu Arg Gln Ser Glu Gly Ser Phe Ser Pro Gln Leu Gln Glu Ser 
                485                 490                 495     


Val Phe His Leu Leu Val Pro Ser Val Ile Leu Val Leu Leu Ala Val 
            500                 505                 510         


Gly Gly Leu Leu Phe Tyr Arg Trp Arg Arg Arg Ser His Gln Glu Pro 
        515                 520                 525             


Gln Arg Ala Asp Ser Pro Leu Glu Gln Pro Glu Gly Ser Pro Leu Thr 
    530                 535                 540                 


Gln Asp Asp Arg Gln Val Glu Leu Pro Val 
545                 550                 


<210>  589
<211>  256
<212>  PRT
<213>  Homo sapiens

<400>  589

Met Thr Ala Pro Gly Ala Ala Gly Arg Cys Pro Pro Thr Thr Trp Leu 
1               5                   10                  15      


Gly Ser Leu Leu Leu Leu Val Cys Leu Leu Ala Ser Arg Ser Ile Thr 
            20                  25                  30          


Glu Glu Val Ser Glu Tyr Cys Ser His Met Ile Gly Ser Gly His Leu 
        35                  40                  45              


Gln Ser Leu Gln Arg Leu Ile Asp Ser Gln Met Glu Thr Ser Cys Gln 
    50                  55                  60                  


Ile Thr Phe Glu Phe Val Asp Gln Glu Gln Leu Lys Asp Pro Val Cys 
65                  70                  75                  80  


Tyr Leu Lys Lys Ala Phe Leu Leu Val Gln Asp Ile Met Glu Asp Thr 
                85                  90                  95      


Met Arg Phe Arg Asp Asn Thr Pro Asn Ala Ile Ala Ile Val Gln Leu 
            100                 105                 110         


Gln Glu Leu Ser Leu Arg Leu Lys Ser Cys Phe Thr Lys Asp Tyr Glu 
        115                 120                 125             


Glu His Asp Lys Ala Cys Val Arg Thr Phe Tyr Glu Thr Pro Leu Gln 
    130                 135                 140                 


Leu Leu Glu Lys Val Lys Asn Val Phe Asn Glu Thr Lys Asn Leu Leu 
145                 150                 155                 160 


Asp Lys Asp Trp Asn Ile Phe Ser Lys Asn Cys Asn Asn Ser Phe Ala 
                165                 170                 175     


Glu Cys Ser Ser Gln Gly His Glu Arg Gln Ser Glu Gly Ser Phe Ser 
            180                 185                 190         


Pro Gln Leu Gln Glu Ser Val Phe His Leu Leu Val Pro Ser Val Ile 
        195                 200                 205             


Leu Val Leu Leu Ala Val Gly Gly Leu Leu Phe Tyr Arg Trp Arg Arg 
    210                 215                 220                 


Arg Ser His Gln Glu Pro Gln Arg Ala Asp Ser Pro Leu Glu Gln Pro 
225                 230                 235                 240 


Glu Gly Ser Pro Leu Thr Gln Asp Asp Arg Gln Val Glu Leu Pro Val 
                245                 250                 255     


<210>  590
<211>  285
<212>  PRT
<213>  Homo sapiens

<400>  590

Met Thr Ala Pro Gly Ala Ala Gly Arg Cys Pro Pro Thr Ile Asp Ser 
1               5                   10                  15      


Gln Met Glu Thr Ser Cys Gln Ile Thr Phe Glu Phe Val Asp Gln Glu 
            20                  25                  30          


Gln Leu Lys Asp Pro Val Cys Tyr Leu Lys Lys Ala Phe Leu Leu Val 
        35                  40                  45              


Gln Asp Ile Met Glu Asp Thr Met Arg Phe Arg Asp Asn Thr Pro Asn 
    50                  55                  60                  


Ala Ile Ala Ile Val Gln Leu Gln Glu Leu Ser Leu Arg Leu Lys Ser 
65                  70                  75                  80  


Cys Phe Thr Lys Asp Tyr Glu Glu His Asp Lys Ala Cys Val Arg Thr 
                85                  90                  95      


Phe Tyr Glu Thr Pro Leu Gln Leu Leu Glu Lys Val Lys Asn Val Phe 
            100                 105                 110         


Asn Glu Thr Lys Asn Leu Leu Asp Lys Asp Trp Asn Ile Phe Ser Lys 
        115                 120                 125             


Asn Cys Asn Asn Ser Phe Ala Glu Cys Ser Ser Gln Asp Val Val Thr 
    130                 135                 140                 


Lys Pro Asp Cys Asn Cys Leu Tyr Pro Lys Ala Ile Pro Ser Ser Asp 
145                 150                 155                 160 


Pro Ala Ser Val Ser Pro His Gln Pro Leu Ala Pro Ser Met Ala Pro 
                165                 170                 175     


Val Ala Gly Leu Thr Trp Glu Asp Ser Glu Gly Thr Glu Gly Ser Ser 
            180                 185                 190         


Leu Leu Pro Gly Glu Gln Pro Leu His Thr Val Asp Pro Gly Ser Ala 
        195                 200                 205             


Lys Gln Arg Pro Pro Arg Ser Thr Cys Gln Ser Phe Glu Pro Pro Glu 
    210                 215                 220                 


Thr Pro Val Val Lys Asp Ser Thr Ile Gly Gly Ser Pro Gln Pro Arg 
225                 230                 235                 240 


Pro Ser Val Gly Ala Phe Asn Pro Gly Met Glu Asp Ile Leu Asp Ser 
                245                 250                 255     


Ala Met Gly Thr Asn Trp Val Pro Glu Glu Ala Ser Gly Glu Ala Ser 
            260                 265                 270         


Glu Ile Pro Val Pro Gln Gly Thr Glu Leu Ser Pro Ser 
        275                 280                 285 


<210>  591
<211>  113
<212>  PRT
<213>  Homo sapiens

<400>  591

Met Ile Gly Ser Gly His Leu Gln Ser Leu Gln Arg Leu Ile Asp Ser 
1               5                   10                  15      


Gln Met Glu Thr Ser Cys Gln Ile Thr Phe Glu Phe Val Asp Gln Glu 
            20                  25                  30          


Gln Leu Lys Asp Pro Val Cys Tyr Leu Lys Lys Ala Phe Leu Leu Val 
        35                  40                  45              


Gln Asp Ile Met Glu Asp Thr Met Arg Phe Arg Asp Asn Thr Pro Asn 
    50                  55                  60                  


Ala Ile Ala Ile Val Gln Leu Gln Glu Leu Ser Leu Arg Leu Lys Ser 
65                  70                  75                  80  


Cys Phe Thr Lys Asp Tyr Glu Glu His Asp Lys Ala Cys Val Arg Thr 
                85                  90                  95      


Phe Tyr Glu Thr Pro Leu Gln Leu Leu Glu Lys Val Lys Asn Val Phe 
            100                 105                 110         


Asn 
    


<210>  592
<211>  150
<212>  PRT
<213>  Homo sapiens

<400>  592

Met Gly Trp Gly Arg Leu Gln Arg Ile Ser Leu Pro Ser Gln Cys Leu 
1               5                   10                  15      


Ser Leu Leu Ser Thr Trp Leu Gly Ser Leu Leu Leu Leu Val Cys Leu 
            20                  25                  30          


Leu Ala Ser Arg Ser Ile Thr Glu Glu Val Ser Glu Tyr Cys Ser His 
        35                  40                  45              


Met Ile Gly Ser Gly His Leu Gln Ser Leu Gln Arg Leu Ile Asp Ser 
    50                  55                  60                  


Gln Met Glu Thr Ser Cys Gln Ile Thr Phe Glu Phe Val Asp Gln Glu 
65                  70                  75                  80  


Gln Leu Lys Asp Pro Val Cys Tyr Leu Lys Lys Ala Phe Leu Leu Val 
                85                  90                  95      


Gln Asp Ile Met Glu Asp Thr Met Arg Phe Arg Asp Asn Thr Pro Asn 
            100                 105                 110         


Ala Ile Ala Ile Val Gln Leu Gln Glu Leu Ser Leu Arg Leu Lys Ser 
        115                 120                 125             


Cys Phe Thr Lys Asp Tyr Glu Glu His Asp Lys Ala Cys Val Arg Thr 
    130                 135                 140                 


Phe Tyr Glu Thr Pro Leu 
145                 150 


<210>  593
<211>  173
<212>  PRT
<213>  Homo sapiens

<400>  593

Met Ala Arg Met Asn Arg Pro Ala Pro Val Glu Val Ser Tyr Lys His 
1               5                   10                  15      


Met Arg Phe Leu Ile Thr His Asn Pro Thr Asn Ala Thr Leu Ser Thr 
            20                  25                  30          


Phe Ile Glu Asp Leu Lys Lys Tyr Gly Ala Thr Thr Val Val Arg Val 
        35                  40                  45              


Cys Glu Val Thr Tyr Asp Lys Thr Pro Leu Glu Lys Asp Gly Ile Thr 
    50                  55                  60                  


Val Val Asp Trp Pro Phe Asp Asp Gly Ala Pro Pro Pro Gly Lys Val 
65                  70                  75                  80  


Val Glu Asp Trp Leu Ser Leu Val Lys Ala Lys Phe Cys Glu Ala Pro 
                85                  90                  95      


Gly Ser Cys Val Ala Val His Cys Val Ala Gly Leu Gly Arg Ala Pro 
            100                 105                 110         


Val Leu Val Ala Leu Ala Leu Ile Glu Ser Gly Met Lys Tyr Glu Asp 
        115                 120                 125             


Ala Ile Gln Phe Ile Arg Gln Lys Arg Arg Gly Ala Ile Asn Ser Lys 
    130                 135                 140                 


Gln Leu Thr Tyr Leu Glu Lys Tyr Arg Pro Lys Gln Arg Leu Arg Phe 
145                 150                 155                 160 


Lys Asp Pro His Thr His Lys Thr Arg Cys Cys Val Met 
                165                 170             


<210>  594
<211>  148
<212>  PRT
<213>  Homo sapiens

<400>  594

Met Ala Arg Met Asn Arg Pro Ala Pro Val Glu Val Ser Tyr Lys His 
1               5                   10                  15      


Met Arg Phe Leu Ile Thr His Asn Pro Thr Asn Ala Thr Leu Ser Thr 
            20                  25                  30          


Phe Ile Glu Asp Leu Lys Lys Tyr Gly Ala Thr Thr Val Val Arg Val 
        35                  40                  45              


Cys Glu Val Thr Tyr Asp Lys Thr Pro Leu Glu Lys Asp Gly Ile Thr 
    50                  55                  60                  


Val Val Asp Trp Pro Phe Asp Asp Gly Ala Pro Pro Pro Gly Lys Val 
65                  70                  75                  80  


Val Glu Asp Trp Leu Ser Leu Val Lys Ala Lys Phe Cys Glu Ala Pro 
                85                  90                  95      


Gly Ser Cys Val Ala Val His Cys Val Ala Gly Leu Gly Arg Lys Arg 
            100                 105                 110         


Arg Gly Ala Ile Asn Ser Lys Gln Leu Thr Tyr Leu Glu Lys Tyr Arg 
        115                 120                 125             


Pro Lys Gln Arg Leu Arg Phe Lys Asp Pro His Thr His Lys Thr Arg 
    130                 135                 140                 


Cys Cys Val Met 
145             


<210>  595
<211>  148
<212>  PRT
<213>  Homo sapiens

<400>  595

Met Ala Arg Met Asn Arg Pro Ala Pro Val Glu Val Ser Tyr Lys His 
1               5                   10                  15      


Met Arg Phe Leu Ile Thr His Asn Pro Thr Asn Ala Thr Leu Ser Thr 
            20                  25                  30          


Phe Ile Glu Asp Leu Lys Lys Tyr Gly Ala Thr Thr Val Val Arg Val 
        35                  40                  45              


Cys Glu Val Thr Tyr Asp Lys Thr Pro Leu Glu Lys Asp Gly Ile Thr 
    50                  55                  60                  


Val Val Asp Trp Pro Phe Asp Asp Gly Ala Pro Pro Pro Gly Lys Val 
65                  70                  75                  80  


Val Glu Asp Trp Leu Ser Leu Val Lys Ala Lys Phe Cys Glu Ala Pro 
                85                  90                  95      


Gly Ser Cys Val Ala Val His Cys Val Ala Gly Leu Gly Arg Lys Arg 
            100                 105                 110         


Arg Gly Ala Ile Asn Ser Lys Gln Leu Thr Tyr Leu Glu Lys Tyr Arg 
        115                 120                 125             


Pro Lys Gln Arg Leu Arg Phe Lys Asp Pro His Thr His Lys Thr Arg 
    130                 135                 140                 


Cys Cys Val Met 
145             


<210>  596
<211>  173
<212>  PRT
<213>  Homo sapiens

<400>  596

Met Ala Arg Met Asn Arg Pro Ala Pro Val Glu Val Ser Tyr Lys His 
1               5                   10                  15      


Met Arg Phe Leu Ile Thr His Asn Pro Thr Asn Ala Thr Leu Ser Thr 
            20                  25                  30          


Phe Ile Glu Asp Leu Lys Lys Tyr Gly Ala Thr Thr Val Val Arg Val 
        35                  40                  45              


Cys Glu Val Thr Tyr Asp Lys Thr Pro Leu Glu Lys Asp Gly Ile Thr 
    50                  55                  60                  


Val Val Asp Trp Pro Phe Asp Asp Gly Ala Pro Pro Pro Gly Lys Val 
65                  70                  75                  80  


Val Glu Asp Trp Leu Ser Leu Val Lys Ala Lys Phe Cys Glu Ala Pro 
                85                  90                  95      


Gly Ser Cys Val Ala Val His Cys Val Ala Gly Leu Gly Arg Ala Pro 
            100                 105                 110         


Val Leu Val Ala Leu Ala Leu Ile Glu Ser Gly Met Lys Tyr Glu Asp 
        115                 120                 125             


Ala Ile Gln Phe Ile Arg Gln Lys Arg Arg Gly Ala Ile Asn Ser Lys 
    130                 135                 140                 


Gln Leu Thr Tyr Leu Glu Lys Tyr Arg Pro Lys Gln Arg Leu Arg Phe 
145                 150                 155                 160 


Lys Asp Pro His Thr His Lys Thr Arg Cys Cys Val Met 
                165                 170             


<210>  597
<211>  70
<212>  PRT
<213>  Homo sapiens

<400>  597

Met Ala Arg Met Asn Arg Pro Ala Pro Val Glu Val Ser Tyr Lys His 
1               5                   10                  15      


Met Arg Phe Leu Ile Thr His Asn Pro Thr Asn Ala Thr Leu Ser Thr 
            20                  25                  30          


Phe Ile Glu Asp Leu Lys Lys Tyr Gly Ala Thr Thr Val Val Arg Val 
        35                  40                  45              


Cys Glu Val Thr Tyr Asp Lys Thr Pro Leu Glu Lys Asp Gly Ile Thr 
    50                  55                  60                  


Val Val Asp Trp Pro Phe 
65                  70  


<210>  598
<211>  87
<212>  PRT
<213>  Homo sapiens

<400>  598

Met Ala Arg Met Asn Arg Pro Ala Pro Val Glu Val Ser Tyr Lys His 
1               5                   10                  15      


Met Arg Phe Leu Ile Thr His Asn Pro Thr Asn Ala Thr Leu Ser Thr 
            20                  25                  30          


Phe Ile Glu Ser Gly Met Lys Tyr Glu Asp Ala Ile Gln Phe Ile Arg 
        35                  40                  45              


Gln Lys Arg Arg Gly Ala Ile Asn Ser Lys Gln Leu Thr Tyr Leu Glu 
    50                  55                  60                  


Lys Tyr Arg Pro Lys Gln Arg Leu Arg Phe Lys Asp Pro His Thr His 
65                  70                  75                  80  


Lys Thr Arg Cys Cys Val Met 
                85          


<210>  599
<211>  25
<212>  PRT
<213>  Homo sapiens

<400>  599

Met Ile Asn Ala Cys Arg Asp Phe Leu Glu Leu Ala Glu Ile His Ser 
1               5                   10                  15      


Arg Lys Trp Gln Arg Ala Leu Gln Tyr 
            20                  25  


<210>  600
<211>  244
<212>  PRT
<213>  Homo sapiens

<400>  600

Met Glu Leu Thr Ile Phe Ile Leu Arg Leu Ala Ile Tyr Ile Leu Thr 
1               5                   10                  15      


Phe Pro Leu Tyr Leu Leu Asn Phe Leu Gly Leu Trp Ser Trp Ile Cys 
            20                  25                  30          


Lys Lys Trp Phe Pro Tyr Phe Leu Val Arg Phe Thr Val Ile Tyr Asn 
        35                  40                  45              


Glu Gln Met Ala Ser Lys Lys Arg Glu Leu Phe Ser Asn Leu Gln Glu 
    50                  55                  60                  


Phe Ala Gly Pro Ser Gly Lys Leu Ser Leu Leu Glu Val Gly Cys Gly 
65                  70                  75                  80  


Thr Gly Ala Asn Phe Lys Phe Tyr Pro Pro Gly Cys Arg Val Thr Cys 
                85                  90                  95      


Ile Asp Pro Asn Pro Asn Phe Glu Lys Phe Leu Ile Lys Ser Ile Ala 
            100                 105                 110         


Glu Asn Arg His Leu Gln Phe Glu Arg Phe Val Val Ala Ala Gly Glu 
        115                 120                 125             


Asn Met His Gln Val Ala Asp Gly Ser Val Asp Val Val Val Cys Thr 
    130                 135                 140                 


Leu Val Leu Cys Ser Val Lys Asn Gln Glu Arg Ile Leu Arg Glu Val 
145                 150                 155                 160 


Cys Arg Val Leu Arg Pro Gly Gly Ala Phe Tyr Phe Met Glu His Val 
                165                 170                 175     


Ala Ala Glu Cys Ser Thr Trp Asn Tyr Phe Trp Gln Gln Val Leu Asp 
            180                 185                 190         


Pro Ala Trp His Leu Leu Phe Asp Gly Cys Asn Leu Thr Arg Glu Ser 
        195                 200                 205             


Trp Lys Ala Leu Glu Arg Ala Ser Phe Ser Lys Leu Lys Leu Gln His 
    210                 215                 220                 


Ile Gln Ala Pro Leu Ser Trp Glu Leu Val Arg Pro His Ile Tyr Gly 
225                 230                 235                 240 


Tyr Ala Val Lys 
                


<210>  601
<211>  244
<212>  PRT
<213>  Homo sapiens

<400>  601

Met Glu Leu Thr Ile Phe Ile Leu Arg Leu Ala Ile Tyr Ile Leu Thr 
1               5                   10                  15      


Phe Pro Leu Tyr Leu Leu Asn Phe Leu Gly Leu Trp Ser Trp Ile Cys 
            20                  25                  30          


Lys Lys Trp Phe Pro Tyr Phe Leu Val Arg Phe Thr Val Ile Tyr Asn 
        35                  40                  45              


Glu Gln Met Ala Ser Lys Lys Arg Glu Leu Phe Ser Asn Leu Gln Glu 
    50                  55                  60                  


Phe Ala Gly Pro Ser Gly Lys Leu Ser Leu Leu Glu Val Gly Cys Gly 
65                  70                  75                  80  


Thr Gly Ala Asn Phe Lys Phe Tyr Pro Pro Gly Cys Arg Val Thr Cys 
                85                  90                  95      


Ile Asp Pro Asn Pro Asn Phe Glu Lys Phe Leu Ile Lys Ser Ile Ala 
            100                 105                 110         


Glu Asn Arg His Leu Gln Phe Glu Arg Phe Val Val Ala Ala Gly Glu 
        115                 120                 125             


Asn Met His Gln Val Ala Asp Gly Ser Val Asp Val Val Val Cys Thr 
    130                 135                 140                 


Leu Val Leu Cys Ser Val Lys Asn Gln Glu Arg Ile Leu Arg Glu Val 
145                 150                 155                 160 


Cys Arg Val Leu Arg Pro Gly Gly Ala Phe Tyr Phe Met Glu His Val 
                165                 170                 175     


Ala Ala Glu Cys Ser Thr Trp Asn Tyr Phe Trp Gln Gln Val Leu Asp 
            180                 185                 190         


Pro Ala Trp His Leu Leu Phe Asp Gly Cys Asn Leu Thr Arg Glu Ser 
        195                 200                 205             


Trp Lys Ala Leu Glu Arg Ala Ser Phe Ser Lys Leu Lys Leu Gln His 
    210                 215                 220                 


Ile Gln Ala Pro Leu Ser Trp Glu Leu Val Arg Pro His Ile Tyr Gly 
225                 230                 235                 240 


Tyr Ala Val Lys 
                


<210>  602
<211>  244
<212>  PRT
<213>  Homo sapiens

<400>  602

Met Glu Leu Thr Ile Phe Ile Leu Arg Leu Ala Ile Tyr Ile Leu Thr 
1               5                   10                  15      


Phe Pro Leu Tyr Leu Leu Asn Phe Leu Gly Leu Trp Ser Trp Ile Cys 
            20                  25                  30          


Lys Lys Trp Phe Pro Tyr Phe Leu Val Arg Phe Thr Val Ile Tyr Asn 
        35                  40                  45              


Glu Gln Met Ala Ser Lys Lys Arg Glu Leu Phe Ser Asn Leu Gln Glu 
    50                  55                  60                  


Phe Ala Gly Pro Ser Gly Lys Leu Ser Leu Leu Glu Val Gly Cys Gly 
65                  70                  75                  80  


Thr Gly Ala Asn Phe Lys Phe Tyr Pro Pro Gly Cys Arg Val Thr Cys 
                85                  90                  95      


Ile Asp Pro Asn Pro Asn Phe Glu Lys Phe Leu Ile Lys Ser Ile Ala 
            100                 105                 110         


Glu Asn Arg His Leu Gln Phe Glu Arg Phe Val Val Ala Ala Gly Glu 
        115                 120                 125             


Asn Met His Gln Val Ala Asp Gly Ser Val Asp Val Val Val Cys Thr 
    130                 135                 140                 


Leu Val Leu Cys Ser Val Lys Asn Gln Glu Arg Ile Leu Arg Glu Val 
145                 150                 155                 160 


Cys Arg Val Leu Arg Pro Gly Gly Ala Phe Tyr Phe Met Glu His Val 
                165                 170                 175     


Ala Ala Glu Cys Ser Thr Trp Asn Tyr Phe Trp Gln Gln Val Leu Asp 
            180                 185                 190         


Pro Ala Trp His Leu Leu Phe Asp Gly Cys Asn Leu Thr Arg Glu Ser 
        195                 200                 205             


Trp Lys Ala Leu Glu Arg Ala Ser Phe Ser Lys Leu Lys Leu Gln His 
    210                 215                 220                 


Ile Gln Ala Pro Leu Ser Trp Glu Leu Val Arg Pro His Ile Tyr Gly 
225                 230                 235                 240 


Tyr Ala Val Lys 
                


<210>  603
<211>  244
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  603

Xaa Glu Leu Thr Ile Phe Ile Leu Arg Leu Ala Ile Tyr Ile Leu Thr 
1               5                   10                  15      


Phe Pro Leu Tyr Leu Leu Asn Phe Leu Gly Leu Trp Ser Trp Ile Cys 
            20                  25                  30          


Lys Lys Trp Phe Pro Tyr Phe Leu Val Arg Phe Thr Val Ile Tyr Asn 
        35                  40                  45              


Glu Gln Met Ala Ser Lys Lys Arg Glu Leu Phe Ser Asn Leu Gln Glu 
    50                  55                  60                  


Phe Ala Gly Pro Ser Gly Lys Leu Ser Leu Leu Glu Val Gly Cys Gly 
65                  70                  75                  80  


Thr Gly Ala Asn Phe Lys Phe Tyr Pro Pro Gly Cys Arg Val Thr Cys 
                85                  90                  95      


Ile Asp Pro Asn Pro Asn Phe Glu Lys Phe Leu Ile Lys Ser Ile Ala 
            100                 105                 110         


Glu Asn Arg His Leu Gln Phe Glu Arg Phe Val Val Ala Ala Gly Glu 
        115                 120                 125             


Asn Met His Gln Val Ala Asp Gly Ser Val Asp Val Val Val Cys Thr 
    130                 135                 140                 


Leu Val Leu Cys Ser Val Lys Asn Gln Glu Arg Ile Leu Arg Glu Val 
145                 150                 155                 160 


Cys Arg Val Leu Arg Pro Gly Gly Ala Phe Tyr Phe Met Glu His Val 
                165                 170                 175     


Ala Ala Glu Cys Ser Thr Trp Asn Tyr Phe Trp Gln Gln Val Leu Asp 
            180                 185                 190         


Pro Ala Trp His Leu Leu Phe Asp Gly Cys Asn Leu Thr Arg Glu Ser 
        195                 200                 205             


Trp Lys Ala Leu Glu Arg Ala Ser Phe Ser Lys Leu Lys Leu Gln His 
    210                 215                 220                 


Ile Gln Ala Pro Leu Ser Trp Glu Leu Val Arg Pro His Ile Tyr Gly 
225                 230                 235                 240 


Tyr Ala Val Lys 
                


<210>  604
<211>  180
<212>  PRT
<213>  Homo sapiens

<400>  604

Met Glu Leu Thr Ile Phe Ile Leu Arg Leu Ala Ile Tyr Ile Leu Thr 
1               5                   10                  15      


Phe Pro Leu Tyr Leu Leu Asn Phe Leu Gly Leu Trp Ser Trp Ile Cys 
            20                  25                  30          


Lys Lys Trp Phe Pro Tyr Phe Leu Val Arg Phe Thr Val Ile Tyr Asn 
        35                  40                  45              


Glu Gln Met Ala Ser Lys Lys Arg Glu Leu Phe Ser Asn Leu Gln Glu 
    50                  55                  60                  


Phe Ala Gly Pro Ser Gly Lys Leu Ser Leu Leu Glu Val Gly Cys Gly 
65                  70                  75                  80  


Thr Gly Ala Asn Phe Lys Phe Tyr Pro Pro Gly Cys Arg Val Thr Cys 
                85                  90                  95      


Ile Asp Pro Asn Pro Asn Phe Glu Lys Phe Leu Ile Lys Ser Ile Ala 
            100                 105                 110         


Glu Asn Arg His Leu Gln Phe Glu Arg Phe Val Val Ala Ala Gly Glu 
        115                 120                 125             


Asn Met His Gln Val Ala Asp Gly Ser Val Asp Val Val Val Cys Thr 
    130                 135                 140                 


Leu Val Leu Cys Ser Val Lys Asn Gln Glu Arg Ile Leu Arg Glu Val 
145                 150                 155                 160 


Cys Arg Val Leu Arg Pro Gly Gly Ala Phe Tyr Phe Met Glu His Val 
                165                 170                 175     


Ala Ala Glu Cys 
            180 


<210>  605
<211>  811
<212>  PRT
<213>  Homo sapiens

<400>  605

Met Leu Leu Leu Phe His Ser Lys Arg Met Pro Val Ala Glu Ala Pro 
1               5                   10                  15      


Gln Val Ala Gly Gly Gln Gly Asp Gly Gly Asp Gly Glu Glu Ala Glu 
            20                  25                  30          


Pro Glu Gly Met Phe Lys Ala Cys Glu Asp Ser Lys Arg Lys Ala Arg 
        35                  40                  45              


Gly Tyr Leu Arg Leu Val Pro Leu Phe Val Leu Leu Ala Leu Leu Val 
    50                  55                  60                  


Leu Ala Ser Ala Gly Val Leu Leu Trp Tyr Phe Leu Gly Tyr Lys Ala 
65                  70                  75                  80  


Glu Val Met Val Ser Gln Val Tyr Ser Gly Ser Leu Arg Val Leu Asn 
                85                  90                  95      


Arg His Phe Ser Gln Asp Leu Thr Arg Arg Glu Ser Ser Ala Phe Arg 
            100                 105                 110         


Ser Glu Thr Ala Lys Ala Gln Lys Met Leu Lys Glu Leu Ile Thr Ser 
        115                 120                 125             


Thr Arg Leu Gly Thr Tyr Tyr Asn Ser Ser Ser Val Tyr Ser Phe Gly 
    130                 135                 140                 


Glu Gly Pro Leu Thr Cys Phe Phe Trp Phe Ile Leu Gln Ile Pro Glu 
145                 150                 155                 160 


His Arg Arg Leu Met Leu Ser Pro Glu Val Val Gln Ala Leu Leu Val 
                165                 170                 175     


Glu Glu Leu Leu Ser Thr Val Asn Ser Ser Ala Ala Val Pro Tyr Arg 
            180                 185                 190         


Ala Glu Tyr Glu Val Asp Pro Glu Gly Leu Val Ile Leu Glu Ala Ser 
        195                 200                 205             


Val Lys Asp Ile Ala Ala Leu Asn Ser Thr Leu Gly Cys Tyr Arg Tyr 
    210                 215                 220                 


Ser Tyr Val Gly Gln Gly Gln Val Leu Arg Leu Lys Gly Pro Asp His 
225                 230                 235                 240 


Leu Ala Ser Ser Cys Leu Trp His Leu Gln Gly Pro Lys Asp Leu Met 
                245                 250                 255     


Leu Lys Leu Arg Leu Glu Trp Thr Leu Ala Glu Cys Arg Asp Arg Leu 
            260                 265                 270         


Ala Met Tyr Asp Val Ala Gly Pro Leu Glu Lys Arg Leu Ile Thr Ser 
        275                 280                 285             


Val Tyr Gly Cys Ser Arg Gln Glu Pro Val Val Glu Val Leu Ala Ser 
    290                 295                 300                 


Gly Ala Ile Met Ala Val Val Trp Lys Lys Gly Leu His Ser Tyr Tyr 
305                 310                 315                 320 


Asp Pro Phe Val Leu Ser Val Gln Pro Val Val Phe Gln Ala Cys Glu 
                325                 330                 335     


Val Asn Leu Thr Leu Asp Asn Arg Leu Asp Ser Gln Gly Val Leu Ser 
            340                 345                 350         


Thr Pro Tyr Phe Pro Ser Tyr Tyr Ser Pro Gln Thr His Cys Ser Trp 
        355                 360                 365             


His Leu Thr Val Pro Ser Leu Asp Tyr Gly Leu Ala Leu Trp Phe Asp 
    370                 375                 380                 


Ala Tyr Ala Leu Arg Arg Gln Lys Tyr Asp Leu Pro Cys Thr Gln Gly 
385                 390                 395                 400 


Gln Trp Thr Ile Gln Asn Arg Arg Leu Cys Gly Leu Arg Ile Leu Gln 
                405                 410                 415     


Pro Tyr Ala Glu Arg Ile Pro Val Val Ala Thr Ala Gly Ile Thr Ile 
            420                 425                 430         


Asn Phe Thr Ser Gln Ile Ser Leu Thr Gly Pro Gly Val Arg Val His 
        435                 440                 445             


Tyr Gly Leu Tyr Asn Gln Ser Asp Pro Cys Pro Gly Glu Phe Leu Cys 
    450                 455                 460                 


Ser Val Asn Gly Leu Cys Val Pro Ala Cys Asp Gly Val Lys Asp Cys 
465                 470                 475                 480 


Pro Asn Gly Leu Asp Glu Arg Asn Cys Val Cys Arg Ala Thr Phe Gln 
                485                 490                 495     


Cys Lys Glu Asp Ser Thr Cys Ile Ser Leu Pro Lys Val Cys Asp Gly 
            500                 505                 510         


Gln Pro Asp Cys Leu Asn Gly Ser Asp Glu Glu Gln Cys Gln Glu Gly 
        515                 520                 525             


Val Pro Cys Gly Thr Phe Thr Phe Gln Cys Glu Asp Arg Ser Cys Val 
    530                 535                 540                 


Lys Lys Pro Asn Pro Gln Cys Asp Gly Arg Pro Asp Cys Arg Asp Gly 
545                 550                 555                 560 


Ser Asp Glu Glu His Cys Asp Cys Gly Leu Gln Gly Pro Ser Ser Arg 
                565                 570                 575     


Ile Val Gly Gly Ala Val Ser Ser Glu Gly Glu Trp Pro Trp Gln Ala 
            580                 585                 590         


Ser Leu Gln Val Arg Gly Arg His Ile Cys Gly Gly Ala Leu Ile Ala 
        595                 600                 605             


Asp Arg Trp Val Ile Thr Ala Ala His Cys Phe Gln Glu Asp Ser Met 
    610                 615                 620                 


Ala Ser Thr Val Leu Trp Thr Val Phe Leu Gly Lys Val Trp Gln Asn 
625                 630                 635                 640 


Ser Arg Trp Pro Gly Glu Val Ser Phe Lys Val Ser Arg Leu Leu Leu 
                645                 650                 655     


His Pro Tyr His Glu Glu Asp Ser His Asp Tyr Asp Val Ala Leu Leu 
            660                 665                 670         


Gln Leu Asp His Pro Val Val Arg Ser Ala Ala Val Arg Pro Val Cys 
        675                 680                 685             


Leu Pro Ala Arg Ser His Phe Phe Glu Pro Gly Leu His Cys Trp Ile 
    690                 695                 700                 


Thr Gly Trp Gly Ala Leu Arg Glu Gly Gly Pro Ile Ser Asn Ala Leu 
705                 710                 715                 720 


Gln Lys Val Asp Val Gln Leu Ile Pro Gln Asp Leu Cys Ser Glu Val 
                725                 730                 735     


Tyr Arg Tyr Gln Val Thr Pro Arg Met Leu Cys Ala Gly Tyr Arg Lys 
            740                 745                 750         


Gly Lys Lys Asp Ala Cys Gln Gly Asp Ser Gly Gly Pro Leu Val Cys 
        755                 760                 765             


Lys Ala Leu Ser Gly Arg Trp Phe Leu Ala Gly Leu Val Ser Trp Gly 
    770                 775                 780                 


Leu Gly Cys Gly Arg Pro Asn Tyr Phe Gly Val Tyr Thr Arg Ile Thr 
785                 790                 795                 800 


Gly Val Ile Ser Trp Ile Gln Gln Val Val Thr 
                805                 810     


<210>  606
<211>  824
<212>  PRT
<213>  Homo sapiens

<400>  606

Met Pro Val Ala Glu Ala Pro Gln Val Ala Gly Gly Gln Gly Asp Gly 
1               5                   10                  15      


Gly Asp Gly Glu Glu Ala Glu Pro Glu Gly Met Phe Lys Ala Cys Glu 
            20                  25                  30          


Asp Ser Lys Arg Lys Ala Arg Gly Tyr Leu Arg Leu Val Pro Leu Phe 
        35                  40                  45              


Val Leu Leu Ala Leu Leu Val Leu Ala Ser Ala Gly Val Leu Leu Trp 
    50                  55                  60                  


Tyr Phe Leu Gly Tyr Lys Ala Glu Val Met Val Ser Gln Val Tyr Ser 
65                  70                  75                  80  


Gly Ser Leu Arg Val Leu Asn Arg His Phe Ser Gln Asp Leu Thr Arg 
                85                  90                  95      


Arg Glu Ser Ser Ala Phe Arg Ser Glu Thr Ala Lys Ala Gln Lys Met 
            100                 105                 110         


Leu Lys Glu Leu Ile Thr Ser Thr Arg Leu Gly Thr Tyr Tyr Asn Ser 
        115                 120                 125             


Ser Ser Val Tyr Ser Phe Gly Glu Gly Pro Leu Thr Cys Phe Phe Trp 
    130                 135                 140                 


Phe Ile Leu Gln Ile Pro Glu His Arg Arg Leu Met Leu Ser Pro Glu 
145                 150                 155                 160 


Val Val Gln Ala Leu Leu Val Glu Glu Leu Leu Ser Thr Val Asn Ser 
                165                 170                 175     


Ser Ala Ala Val Pro Tyr Arg Ala Glu Tyr Glu Val Asp Pro Glu Gly 
            180                 185                 190         


Leu Val Ile Leu Glu Ala Ser Val Lys Asp Ile Ala Ala Leu Asn Ser 
        195                 200                 205             


Thr Leu Gly Cys Tyr Arg Tyr Ser Tyr Val Gly Gln Gly Gln Val Leu 
    210                 215                 220                 


Arg Leu Lys Gly Pro Asp His Leu Ala Ser Ser Cys Leu Trp His Leu 
225                 230                 235                 240 


Gln Gly Pro Lys Asp Leu Met Leu Lys Leu Arg Leu Glu Trp Thr Leu 
                245                 250                 255     


Ala Glu Cys Arg Asp Arg Leu Ala Met Tyr Asp Val Ala Gly Pro Leu 
            260                 265                 270         


Glu Lys Arg Leu Ile Thr Ser Val Tyr Gly Cys Ser Arg Gln Glu Pro 
        275                 280                 285             


Val Val Glu Val Leu Ala Ser Gly Ala Ile Met Ala Val Val Trp Lys 
    290                 295                 300                 


Lys Gly Leu His Ser Tyr Tyr Asp Pro Phe Val Leu Ser Val Gln Pro 
305                 310                 315                 320 


Val Val Phe Gln Ala Cys Glu Val Asn Leu Thr Leu Asp Asn Arg Leu 
                325                 330                 335     


Asp Ser Gln Gly Val Leu Ser Thr Pro Tyr Phe Pro Ser Tyr Tyr Ser 
            340                 345                 350         


Pro Gln Thr His Cys Ser Trp His Leu Thr Val Pro Ser Leu Asp Tyr 
        355                 360                 365             


Gly Leu Ala Leu Trp Phe Asp Ala Tyr Ala Leu Arg Arg Gln Lys Tyr 
    370                 375                 380                 


Asp Leu Pro Cys Thr Gln Gly Gln Trp Thr Ile Gln Asn Arg Arg Leu 
385                 390                 395                 400 


Cys Gly Leu Arg Ile Leu Gln Pro Tyr Ala Glu Arg Ile Pro Val Val 
                405                 410                 415     


Ala Thr Ala Gly Ile Thr Ile Asn Phe Thr Ser Gln Ile Ser Leu Thr 
            420                 425                 430         


Gly Pro Gly Val Arg Val His Tyr Gly Leu Tyr Asn Gln Ser Asp Pro 
        435                 440                 445             


Cys Pro Gly Glu Phe Leu Cys Ser Val Asn Gly Leu Cys Val Pro Ala 
    450                 455                 460                 


Cys Asp Gly Val Lys Asp Cys Pro Asn Gly Leu Asp Glu Arg Asn Cys 
465                 470                 475                 480 


Val Cys Arg Ala Thr Phe Gln Cys Lys Glu Asp Ser Thr Cys Ile Ser 
                485                 490                 495     


Leu Pro Lys Val Cys Asp Gly Gln Pro Asp Cys Leu Asn Gly Ser Asp 
            500                 505                 510         


Glu Glu Gln Cys Gln Glu Gly Val Pro Cys Gly Thr Phe Thr Phe Gln 
        515                 520                 525             


Cys Glu Asp Arg Ser Cys Val Lys Lys Pro Asn Pro Gln Cys Asp Gly 
    530                 535                 540                 


Arg Pro Asp Cys Arg Asp Gly Ser Asp Glu Glu His Cys Asp Cys Gly 
545                 550                 555                 560 


Leu Gln Gly Pro Ser Ser Arg Ile Val Gly Gly Ala Val Ser Ser Glu 
                565                 570                 575     


Gly Glu Trp Pro Trp Gln Ala Ser Leu Gln Val Arg Gly Arg His Ile 
            580                 585                 590         


Cys Gly Gly Ala Leu Ile Ala Asp Arg Trp Val Ile Thr Ala Ala His 
        595                 600                 605             


Cys Phe Gln Glu Asp Ser Met Ala Ser Thr Val Leu Trp Thr Val Phe 
    610                 615                 620                 


Leu Gly Lys Val Trp Gln Asn Ser Arg Trp Pro Gly Glu Val Ser Phe 
625                 630                 635                 640 


Lys Val Ser Arg Leu Leu Leu His Pro Tyr His Glu Glu Asp Ser His 
                645                 650                 655     


Asp Tyr Asp Val Ala Leu Leu Gln Leu Asp His Pro Val Val Arg Ser 
            660                 665                 670         


Ala Ala Val Arg Pro Val Cys Leu Pro Ala Arg Ser His Phe Phe Glu 
        675                 680                 685             


Pro Gly Leu His Cys Trp Ile Thr Gly Trp Gly Ala Leu Arg Glu Gly 
    690                 695                 700                 


Ala Leu Arg Ala Asp Ala Val Ala Leu Phe Tyr Gly Trp Arg Asn Gln 
705                 710                 715                 720 


Gly Ser Glu Thr Cys Cys Cys Pro Ile Ser Asn Ala Leu Gln Lys Val 
                725                 730                 735     


Asp Val Gln Leu Ile Pro Gln Asp Leu Cys Ser Glu Val Tyr Arg Tyr 
            740                 745                 750         


Gln Val Thr Pro Arg Met Leu Cys Ala Gly Tyr Arg Lys Gly Lys Lys 
        755                 760                 765             


Asp Ala Cys Gln Gly Asp Ser Gly Gly Pro Leu Val Cys Lys Ala Leu 
    770                 775                 780                 


Ser Gly Arg Trp Phe Leu Ala Gly Leu Val Ser Trp Gly Leu Gly Cys 
785                 790                 795                 800 


Gly Arg Pro Asn Tyr Phe Gly Val Tyr Thr Arg Ile Thr Gly Val Ile 
                805                 810                 815     


Ser Trp Ile Gln Gln Val Val Thr 
            820                 


<210>  607
<211>  802
<212>  PRT
<213>  Homo sapiens

<400>  607

Met Pro Val Ala Glu Ala Pro Gln Val Ala Gly Gly Gln Gly Asp Gly 
1               5                   10                  15      


Gly Asp Gly Glu Glu Ala Glu Pro Glu Gly Met Phe Lys Ala Cys Glu 
            20                  25                  30          


Asp Ser Lys Arg Lys Ala Arg Gly Tyr Leu Arg Leu Val Pro Leu Phe 
        35                  40                  45              


Val Leu Leu Ala Leu Leu Val Leu Ala Ser Ala Gly Val Leu Leu Trp 
    50                  55                  60                  


Tyr Phe Leu Gly Tyr Lys Ala Glu Val Met Val Ser Gln Val Tyr Ser 
65                  70                  75                  80  


Gly Ser Leu Arg Val Leu Asn Arg His Phe Ser Gln Asp Leu Thr Arg 
                85                  90                  95      


Arg Glu Ser Ser Ala Phe Arg Ser Glu Thr Ala Lys Ala Gln Lys Met 
            100                 105                 110         


Leu Lys Glu Leu Ile Thr Ser Thr Arg Leu Gly Thr Tyr Tyr Asn Ser 
        115                 120                 125             


Ser Ser Val Tyr Ser Phe Gly Glu Gly Pro Leu Thr Cys Phe Phe Trp 
    130                 135                 140                 


Phe Ile Leu Gln Ile Pro Glu His Arg Arg Leu Met Leu Ser Pro Glu 
145                 150                 155                 160 


Val Val Gln Ala Leu Leu Val Glu Glu Leu Leu Ser Thr Val Asn Ser 
                165                 170                 175     


Ser Ala Ala Val Pro Tyr Arg Ala Glu Tyr Glu Val Asp Pro Glu Gly 
            180                 185                 190         


Leu Val Ile Leu Glu Ala Ser Val Lys Asp Ile Ala Ala Leu Asn Ser 
        195                 200                 205             


Thr Leu Gly Cys Tyr Arg Tyr Ser Tyr Val Gly Gln Gly Gln Val Leu 
    210                 215                 220                 


Arg Leu Lys Gly Pro Asp His Leu Ala Ser Ser Cys Leu Trp His Leu 
225                 230                 235                 240 


Gln Gly Pro Lys Asp Leu Met Leu Lys Leu Arg Leu Glu Trp Thr Leu 
                245                 250                 255     


Ala Glu Cys Arg Asp Arg Leu Ala Met Tyr Asp Val Ala Gly Pro Leu 
            260                 265                 270         


Glu Lys Arg Leu Ile Thr Ser Val Tyr Gly Cys Ser Arg Gln Glu Pro 
        275                 280                 285             


Val Val Glu Val Leu Ala Ser Gly Ala Ile Met Ala Val Val Trp Lys 
    290                 295                 300                 


Lys Gly Leu His Ser Tyr Tyr Asp Pro Phe Val Leu Ser Val Gln Pro 
305                 310                 315                 320 


Val Val Phe Gln Ala Cys Glu Val Asn Leu Thr Leu Asp Asn Arg Leu 
                325                 330                 335     


Asp Ser Gln Gly Val Leu Ser Thr Pro Tyr Phe Pro Ser Tyr Tyr Ser 
            340                 345                 350         


Pro Gln Thr His Cys Ser Trp His Leu Thr Val Pro Ser Leu Asp Tyr 
        355                 360                 365             


Gly Leu Ala Leu Trp Phe Asp Ala Tyr Ala Leu Arg Arg Gln Lys Tyr 
    370                 375                 380                 


Asp Leu Pro Cys Thr Gln Gly Gln Trp Thr Ile Gln Asn Arg Arg Leu 
385                 390                 395                 400 


Cys Gly Leu Arg Ile Leu Gln Pro Tyr Ala Glu Arg Ile Pro Val Val 
                405                 410                 415     


Ala Thr Ala Gly Ile Thr Ile Asn Phe Thr Ser Gln Ile Ser Leu Thr 
            420                 425                 430         


Gly Pro Gly Val Arg Val His Tyr Gly Leu Tyr Asn Gln Ser Asp Pro 
        435                 440                 445             


Cys Pro Gly Glu Phe Leu Cys Ser Val Asn Gly Leu Cys Val Pro Ala 
    450                 455                 460                 


Cys Asp Gly Val Lys Asp Cys Pro Asn Gly Leu Asp Glu Arg Asn Cys 
465                 470                 475                 480 


Val Cys Arg Ala Thr Phe Gln Cys Lys Glu Asp Ser Thr Cys Ile Ser 
                485                 490                 495     


Leu Pro Lys Val Cys Asp Gly Gln Pro Asp Cys Leu Asn Gly Ser Asp 
            500                 505                 510         


Glu Glu Gln Cys Gln Glu Gly Val Pro Cys Gly Thr Phe Thr Phe Gln 
        515                 520                 525             


Cys Glu Asp Arg Ser Cys Val Lys Lys Pro Asn Pro Gln Cys Asp Gly 
    530                 535                 540                 


Arg Pro Asp Cys Arg Asp Gly Ser Asp Glu Glu His Cys Asp Cys Gly 
545                 550                 555                 560 


Leu Gln Gly Pro Ser Ser Arg Ile Val Gly Gly Ala Val Ser Ser Glu 
                565                 570                 575     


Gly Glu Trp Pro Trp Gln Ala Ser Leu Gln Val Arg Gly Arg His Ile 
            580                 585                 590         


Cys Gly Gly Ala Leu Ile Ala Asp Arg Trp Val Ile Thr Ala Ala His 
        595                 600                 605             


Cys Phe Gln Glu Asp Ser Met Ala Ser Thr Val Leu Trp Thr Val Phe 
    610                 615                 620                 


Leu Gly Lys Val Trp Gln Asn Ser Arg Trp Pro Gly Glu Val Ser Phe 
625                 630                 635                 640 


Lys Val Ser Arg Leu Leu Leu His Pro Tyr His Glu Glu Asp Ser His 
                645                 650                 655     


Asp Tyr Asp Val Ala Leu Leu Gln Leu Asp His Pro Val Val Arg Ser 
            660                 665                 670         


Ala Ala Val Arg Pro Val Cys Leu Pro Ala Arg Ser His Phe Phe Glu 
        675                 680                 685             


Pro Gly Leu His Cys Trp Ile Thr Gly Trp Gly Ala Leu Arg Glu Gly 
    690                 695                 700                 


Gly Pro Ile Ser Asn Ala Leu Gln Lys Val Asp Val Gln Leu Ile Pro 
705                 710                 715                 720 


Gln Asp Leu Cys Ser Glu Val Tyr Arg Tyr Gln Val Thr Pro Arg Met 
                725                 730                 735     


Leu Cys Ala Gly Tyr Arg Lys Gly Lys Lys Asp Ala Cys Gln Gly Asp 
            740                 745                 750         


Ser Gly Gly Pro Leu Val Cys Lys Ala Leu Ser Gly Arg Trp Phe Leu 
        755                 760                 765             


Ala Gly Leu Val Ser Trp Gly Leu Gly Cys Gly Arg Pro Asn Tyr Phe 
    770                 775                 780                 


Gly Val Tyr Thr Arg Ile Thr Gly Val Ile Ser Trp Ile Gln Gln Val 
785                 790                 795                 800 


Val Thr 
        


<210>  608
<211>  824
<212>  PRT
<213>  Homo sapiens

<400>  608

Met Pro Val Ala Glu Ala Pro Gln Val Ala Gly Gly Gln Gly Asp Gly 
1               5                   10                  15      


Gly Asp Gly Glu Glu Ala Glu Pro Glu Gly Met Phe Lys Ala Cys Glu 
            20                  25                  30          


Asp Ser Lys Arg Lys Ala Arg Gly Tyr Leu Arg Leu Val Pro Leu Phe 
        35                  40                  45              


Val Leu Leu Ala Leu Leu Val Leu Ala Ser Ala Gly Val Leu Leu Trp 
    50                  55                  60                  


Tyr Phe Leu Gly Tyr Lys Ala Glu Val Met Val Ser Gln Val Tyr Ser 
65                  70                  75                  80  


Gly Ser Leu Arg Val Leu Asn Arg His Phe Ser Gln Asp Leu Thr Arg 
                85                  90                  95      


Arg Glu Ser Ser Ala Phe Arg Ser Glu Thr Ala Lys Ala Gln Lys Met 
            100                 105                 110         


Leu Lys Glu Leu Ile Thr Ser Thr Arg Leu Gly Thr Tyr Tyr Asn Ser 
        115                 120                 125             


Ser Ser Val Tyr Ser Phe Gly Glu Gly Pro Leu Thr Cys Phe Phe Trp 
    130                 135                 140                 


Phe Ile Leu Gln Ile Pro Glu His Arg Arg Leu Met Leu Ser Pro Glu 
145                 150                 155                 160 


Val Val Gln Ala Leu Leu Val Glu Glu Leu Leu Ser Thr Val Asn Ser 
                165                 170                 175     


Ser Ala Ala Val Pro Tyr Arg Ala Glu Tyr Glu Val Asp Pro Glu Gly 
            180                 185                 190         


Leu Val Ile Leu Glu Ala Ser Val Lys Asp Ile Ala Ala Leu Asn Ser 
        195                 200                 205             


Thr Leu Gly Cys Tyr Arg Tyr Ser Tyr Val Gly Gln Gly Gln Val Leu 
    210                 215                 220                 


Arg Leu Lys Gly Pro Asp His Leu Ala Ser Ser Cys Leu Trp His Leu 
225                 230                 235                 240 


Gln Gly Pro Lys Asp Leu Met Leu Lys Leu Arg Leu Glu Trp Thr Leu 
                245                 250                 255     


Ala Glu Cys Arg Asp Arg Leu Ala Met Tyr Asp Val Ala Gly Pro Leu 
            260                 265                 270         


Glu Lys Arg Leu Ile Thr Ser Val Tyr Gly Cys Ser Arg Gln Glu Pro 
        275                 280                 285             


Val Val Glu Val Leu Ala Ser Gly Ala Ile Met Ala Val Val Trp Lys 
    290                 295                 300                 


Lys Gly Leu His Ser Tyr Tyr Asp Pro Phe Val Leu Ser Val Gln Pro 
305                 310                 315                 320 


Val Val Phe Gln Ala Cys Glu Val Asn Leu Thr Leu Asp Asn Arg Leu 
                325                 330                 335     


Asp Ser Gln Gly Val Leu Ser Thr Pro Tyr Phe Pro Ser Tyr Tyr Ser 
            340                 345                 350         


Pro Gln Thr His Cys Ser Trp His Leu Thr Val Pro Ser Leu Asp Tyr 
        355                 360                 365             


Gly Leu Ala Leu Trp Phe Asp Ala Tyr Ala Leu Arg Arg Gln Lys Tyr 
    370                 375                 380                 


Asp Leu Pro Cys Thr Gln Gly Gln Trp Thr Ile Gln Asn Arg Arg Leu 
385                 390                 395                 400 


Cys Gly Leu Arg Ile Leu Gln Pro Tyr Ala Glu Arg Ile Pro Val Val 
                405                 410                 415     


Ala Thr Ala Gly Ile Thr Ile Asn Phe Thr Ser Gln Ile Ser Leu Thr 
            420                 425                 430         


Gly Pro Gly Val Arg Val His Tyr Gly Leu Tyr Asn Gln Ser Asp Pro 
        435                 440                 445             


Cys Pro Gly Glu Phe Leu Cys Ser Val Asn Gly Leu Cys Val Pro Ala 
    450                 455                 460                 


Cys Asp Gly Val Lys Asp Cys Pro Asn Gly Leu Asp Glu Arg Asn Cys 
465                 470                 475                 480 


Val Cys Arg Ala Thr Phe Gln Cys Lys Glu Asp Ser Thr Cys Ile Ser 
                485                 490                 495     


Leu Pro Lys Val Cys Asp Gly Gln Pro Asp Cys Leu Asn Gly Ser Asp 
            500                 505                 510         


Glu Glu Gln Cys Gln Glu Gly Val Pro Cys Gly Thr Phe Thr Phe Gln 
        515                 520                 525             


Cys Glu Asp Arg Ser Cys Val Lys Lys Pro Asn Pro Gln Cys Asp Gly 
    530                 535                 540                 


Arg Pro Asp Cys Arg Asp Gly Ser Asp Glu Glu His Cys Asp Cys Gly 
545                 550                 555                 560 


Leu Gln Gly Pro Ser Ser Arg Ile Val Gly Gly Ala Val Ser Ser Glu 
                565                 570                 575     


Gly Glu Trp Pro Trp Gln Ala Ser Leu Gln Val Arg Gly Arg His Ile 
            580                 585                 590         


Cys Gly Gly Ala Leu Ile Ala Asp Arg Trp Val Ile Thr Ala Ala His 
        595                 600                 605             


Cys Phe Gln Glu Asp Ser Met Ala Ser Thr Val Leu Trp Thr Val Phe 
    610                 615                 620                 


Leu Gly Lys Val Trp Gln Asn Ser Arg Trp Pro Gly Glu Val Ser Phe 
625                 630                 635                 640 


Lys Val Ser Arg Leu Leu Leu His Pro Tyr His Glu Glu Asp Ser His 
                645                 650                 655     


Asp Tyr Asp Val Ala Leu Leu Gln Leu Asp His Pro Val Val Arg Ser 
            660                 665                 670         


Ala Ala Val Arg Pro Val Cys Leu Pro Ala Arg Ser His Phe Phe Glu 
        675                 680                 685             


Pro Gly Leu His Cys Trp Ile Thr Gly Trp Gly Ala Leu Arg Glu Gly 
    690                 695                 700                 


Ala Leu Arg Ala Asp Ala Val Ala Leu Phe Tyr Gly Trp Arg Asn Gln 
705                 710                 715                 720 


Gly Ser Glu Thr Cys Cys Cys Pro Ile Ser Asn Ala Leu Gln Lys Val 
                725                 730                 735     


Asp Val Gln Leu Ile Pro Gln Asp Leu Cys Ser Glu Val Tyr Arg Tyr 
            740                 745                 750         


Gln Val Thr Pro Arg Met Leu Cys Ala Gly Tyr Arg Lys Gly Lys Lys 
        755                 760                 765             


Asp Ala Cys Gln Gly Asp Ser Gly Gly Pro Leu Val Cys Lys Ala Leu 
    770                 775                 780                 


Ser Gly Arg Trp Phe Leu Ala Gly Leu Val Ser Trp Gly Leu Gly Cys 
785                 790                 795                 800 


Gly Arg Pro Asn Tyr Phe Gly Val Tyr Thr Arg Ile Thr Gly Val Ile 
                805                 810                 815     


Ser Trp Ile Gln Gln Val Val Thr 
            820                 


<210>  609
<211>  141
<212>  PRT
<213>  Homo sapiens

<400>  609

Met Pro Val Ala Glu Ala Pro Gln Val Ala Gly Gly Gln Gly Asp Gly 
1               5                   10                  15      


Gly Asp Gly Glu Glu Ala Glu Pro Glu Gly Met Phe Lys Ala Cys Glu 
            20                  25                  30          


Asp Ser Lys Arg Lys Ala Arg Gly Tyr Leu Arg Leu Val Pro Leu Phe 
        35                  40                  45              


Val Leu Leu Ala Leu Leu Val Leu Ala Ser Ala Gly Val Leu Leu Trp 
    50                  55                  60                  


Tyr Phe Leu Gly Tyr Lys Ala Glu Val Met Val Ser Gln Val Tyr Ser 
65                  70                  75                  80  


Gly Ser Leu Arg Val Leu Asn Arg His Phe Ser Gln Asp Leu Thr Arg 
                85                  90                  95      


Arg Glu Ser Ser Ala Phe Arg Ser Glu Thr Ala Lys Ala Gln Lys Met 
            100                 105                 110         


Leu Lys Glu Leu Ile Thr Ser Thr Arg Leu Gly Thr Tyr Tyr Asn Ser 
        115                 120                 125             


Ser Ser Val Tyr Ser Phe Gly Glu Gly Pro Leu Thr Cys 
    130                 135                 140     


<210>  610
<211>  71
<212>  PRT
<213>  Homo sapiens

<400>  610

Leu Thr Leu Asp Asn Arg Leu Asp Ser Gln Gly Val Leu Ser Thr Pro 
1               5                   10                  15      


Tyr Phe Pro Ser Tyr Tyr Ser Pro Gln Thr His Cys Ser Trp His Leu 
            20                  25                  30          


Thr Val Pro Ser Leu Asp Tyr Gly Leu Ala Leu Trp Phe Asp Ala Tyr 
        35                  40                  45              


Ala Leu Arg Arg Gln Lys Tyr Asp Leu Pro Cys Thr Gln Gly Gln Trp 
    50                  55                  60                  


Thr Ile Gln Asn Arg Arg Val 
65                  70      


<210>  611
<211>  461
<212>  PRT
<213>  Homo sapiens

<400>  611

Met Leu Leu Leu Phe His Ser Lys Arg Met Pro Val Ala Glu Ala Pro 
1               5                   10                  15      


Gln Val Ala Gly Gly Gln Gly Asp Gly Gly Asp Gly Glu Glu Ala Glu 
            20                  25                  30          


Pro Glu Gly Met Phe Lys Ala Cys Glu Asp Ser Lys Arg Lys Ala Arg 
        35                  40                  45              


Gly Tyr Leu Arg Leu Val Pro Leu Phe Val Leu Leu Ala Leu Leu Val 
    50                  55                  60                  


Leu Ala Ser Ala Gly Val Leu Leu Trp Tyr Phe Leu Gly Tyr Lys Ala 
65                  70                  75                  80  


Glu Val Met Val Ser Gln Val Tyr Ser Gly Ser Leu Arg Val Leu Asn 
                85                  90                  95      


Arg His Phe Ser Gln Asp Leu Thr Arg Arg Glu Ser Ser Ala Phe Arg 
            100                 105                 110         


Ser Glu Thr Ala Lys Ala Gln Lys Met Leu Lys Glu Leu Ile Thr Ser 
        115                 120                 125             


Thr Arg Leu Gly Thr Tyr Tyr Asn Ser Ser Ser Val Tyr Ser Phe Gly 
    130                 135                 140                 


Glu Gly Pro Leu Thr Cys Phe Phe Trp Phe Ile Leu Gln Ile Pro Glu 
145                 150                 155                 160 


His Arg Arg Leu Met Leu Ser Pro Glu Val Val Gln Ala Leu Leu Val 
                165                 170                 175     


Glu Glu Leu Leu Ser Thr Val Asn Ser Ser Ala Ala Val Pro Tyr Arg 
            180                 185                 190         


Ala Glu Tyr Glu Val Asp Pro Glu Gly Leu Val Ile Leu Glu Ala Ser 
        195                 200                 205             


Val Lys Asp Ile Ala Ala Leu Asn Ser Thr Leu Gly Cys Tyr Arg Tyr 
    210                 215                 220                 


Ser Tyr Val Gly Gln Gly Gln Val Leu Arg Leu Lys Gly Pro Asp His 
225                 230                 235                 240 


Leu Ala Ser Ser Cys Leu Trp His Leu Gln Gly Pro Lys Asp Leu Met 
                245                 250                 255     


Leu Lys Leu Arg Leu Glu Trp Thr Leu Ala Glu Cys Arg Asp Arg Leu 
            260                 265                 270         


Ala Met Tyr Asp Val Ala Gly Pro Leu Glu Lys Arg Leu Ile Thr Ser 
        275                 280                 285             


Val Tyr Gly Cys Ser Arg Gln Glu Pro Val Val Glu Val Leu Ala Ser 
    290                 295                 300                 


Gly Ala Ile Met Ala Val Val Trp Lys Lys Gly Leu His Ser Tyr Tyr 
305                 310                 315                 320 


Asp Pro Phe Val Leu Ser Val Gln Pro Val Val Phe Gln Ala Cys Glu 
                325                 330                 335     


Val Asn Leu Thr Leu Asp Asn Arg Leu Asp Ser Gln Gly Val Leu Ser 
            340                 345                 350         


Thr Pro Tyr Phe Pro Ser Tyr Tyr Ser Pro Gln Thr His Cys Ser Trp 
        355                 360                 365             


His Leu Thr Val Pro Ser Leu Asp Tyr Gly Leu Ala Leu Trp Phe Asp 
    370                 375                 380                 


Ala Tyr Ala Leu Arg Arg Gln Lys Tyr Asp Leu Pro Cys Thr Gln Gly 
385                 390                 395                 400 


Gln Trp Thr Ile Gln Asn Arg Arg Tyr His Phe Leu Ser Ser Leu Trp 
                405                 410                 415     


Leu Pro Phe Leu Pro Pro Pro Pro Ser Leu Pro Ser Ser Ile Val Thr 
            420                 425                 430         


Pro Ser Leu Glu Ala Gln Val Pro Asn Leu Arg Gly Ala Ala Arg Gly 
        435                 440                 445             


Ala Ser Arg Gly Trp Gly Trp Cys Gln Ala Cys Cys Pro 
    450                 455                 460     


<210>  612
<211>  428
<212>  PRT
<213>  Homo sapiens

<400>  612

Met Leu Arg Thr Leu Leu Arg Arg Arg Leu Phe Ser Tyr Pro Thr Lys 
1               5                   10                  15      


Tyr Tyr Phe Met Val Leu Val Leu Ser Leu Ile Thr Phe Ser Val Leu 
            20                  25                  30          


Arg Ile His Gln Lys Pro Glu Phe Val Ser Val Arg His Leu Glu Leu 
        35                  40                  45              


Ala Gly Glu Asn Pro Ser Ser Asp Ile Asn Cys Thr Lys Val Leu Gln 
    50                  55                  60                  


Gly Asp Val Asn Glu Ile Gln Lys Val Lys Leu Glu Ile Leu Thr Val 
65                  70                  75                  80  


Lys Phe Lys Lys Arg Pro Arg Trp Thr Pro Asp Asp Tyr Ile Asn Met 
                85                  90                  95      


Thr Ser Asp Cys Ser Ser Phe Ile Lys Arg Arg Lys Tyr Ile Val Glu 
            100                 105                 110         


Pro Leu Ser Lys Glu Glu Ala Glu Phe Pro Ile Ala Tyr Ser Ile Val 
        115                 120                 125             


Val His His Lys Ile Glu Met Leu Asp Arg Leu Leu Arg Ala Ile Tyr 
    130                 135                 140                 


Met Pro Gln Asn Phe Tyr Cys Ile His Val Asp Thr Lys Ser Glu Asp 
145                 150                 155                 160 


Ser Tyr Leu Ala Ala Val Met Gly Ile Ala Ser Cys Phe Ser Asn Val 
                165                 170                 175     


Phe Val Ala Ser Arg Leu Glu Ser Val Val Tyr Ala Ser Trp Ser Arg 
            180                 185                 190         


Val Gln Ala Asp Leu Asn Cys Met Lys Asp Leu Tyr Ala Met Ser Ala 
        195                 200                 205             


Asn Trp Lys Tyr Leu Ile Asn Leu Cys Gly Met Asp Phe Pro Ile Lys 
    210                 215                 220                 


Thr Asn Leu Glu Ile Val Arg Lys Leu Lys Leu Leu Met Gly Glu Asn 
225                 230                 235                 240 


Asn Leu Glu Thr Glu Arg Met Pro Ser His Lys Glu Glu Arg Trp Lys 
                245                 250                 255     


Lys Arg Tyr Glu Val Val Asn Gly Lys Leu Thr Asn Thr Gly Thr Val 
            260                 265                 270         


Lys Met Leu Pro Pro Leu Glu Thr Pro Leu Phe Ser Gly Ser Ala Tyr 
        275                 280                 285             


Phe Val Val Ser Arg Glu Tyr Val Gly Tyr Val Leu Gln Asn Glu Lys 
    290                 295                 300                 


Ile Gln Lys Leu Met Glu Trp Ala Gln Asp Thr Tyr Ser Pro Asp Glu 
305                 310                 315                 320 


Tyr Leu Trp Ala Thr Ile Gln Arg Ile Pro Glu Val Pro Gly Ser Leu 
                325                 330                 335     


Pro Ala Ser His Lys Tyr Asp Leu Ser Asp Met Gln Ala Val Ala Arg 
            340                 345                 350         


Phe Val Lys Trp Gln Tyr Phe Glu Gly Asp Val Ser Lys Gly Ala Pro 
        355                 360                 365             


Tyr Pro Pro Cys Asp Gly Val His Val Arg Ser Val Cys Ile Phe Gly 
    370                 375                 380                 


Ala Gly Asp Leu Asn Trp Met Leu Arg Lys His His Leu Phe Ala Asn 
385                 390                 395                 400 


Lys Phe Asp Val Asp Val Asp Leu Phe Ala Ile Gln Cys Leu Asp Glu 
                405                 410                 415     


His Leu Arg His Lys Ala Leu Glu Thr Leu Lys His 
            420                 425             


<210>  613
<211>  428
<212>  PRT
<213>  Homo sapiens

<400>  613

Met Leu Arg Thr Leu Leu Arg Arg Arg Leu Phe Ser Tyr Pro Thr Lys 
1               5                   10                  15      


Tyr Tyr Phe Met Val Leu Val Leu Ser Leu Ile Thr Phe Ser Val Leu 
            20                  25                  30          


Arg Ile His Gln Lys Pro Glu Phe Val Ser Val Arg His Leu Glu Leu 
        35                  40                  45              


Ala Gly Glu Asn Pro Ser Ser Asp Ile Asn Cys Thr Lys Val Leu Gln 
    50                  55                  60                  


Gly Asp Val Asn Glu Ile Gln Lys Val Lys Leu Glu Ile Leu Thr Val 
65                  70                  75                  80  


Lys Phe Lys Lys Arg Pro Arg Trp Thr Pro Asp Asp Tyr Ile Asn Met 
                85                  90                  95      


Thr Ser Asp Cys Ser Ser Phe Ile Lys Arg Arg Lys Tyr Ile Val Glu 
            100                 105                 110         


Pro Leu Ser Lys Glu Glu Ala Glu Phe Pro Ile Ala Tyr Ser Ile Val 
        115                 120                 125             


Val His His Lys Ile Glu Met Leu Asp Arg Leu Leu Arg Ala Ile Tyr 
    130                 135                 140                 


Met Pro Gln Asn Phe Tyr Cys Ile His Val Asp Thr Lys Ser Glu Asp 
145                 150                 155                 160 


Ser Tyr Leu Ala Ala Val Met Gly Ile Ala Ser Cys Phe Ser Asn Val 
                165                 170                 175     


Phe Val Ala Ser Arg Leu Glu Ser Val Val Tyr Ala Ser Trp Ser Arg 
            180                 185                 190         


Val Gln Ala Asp Leu Asn Cys Met Lys Asp Leu Tyr Ala Met Ser Ala 
        195                 200                 205             


Asn Trp Lys Tyr Leu Ile Asn Leu Cys Gly Met Asp Phe Pro Ile Lys 
    210                 215                 220                 


Thr Asn Leu Glu Ile Val Arg Lys Leu Lys Leu Leu Met Gly Glu Asn 
225                 230                 235                 240 


Asn Leu Glu Thr Glu Arg Met Pro Ser His Lys Glu Glu Arg Trp Lys 
                245                 250                 255     


Lys Arg Tyr Glu Val Val Asn Gly Lys Leu Thr Asn Thr Gly Thr Val 
            260                 265                 270         


Lys Met Leu Pro Pro Leu Glu Thr Pro Leu Phe Ser Gly Ser Ala Tyr 
        275                 280                 285             


Phe Val Val Ser Arg Glu Tyr Val Gly Tyr Val Leu Gln Asn Glu Lys 
    290                 295                 300                 


Ile Gln Lys Leu Met Glu Trp Ala Gln Asp Thr Tyr Ser Pro Asp Glu 
305                 310                 315                 320 


Tyr Leu Trp Ala Thr Ile Gln Arg Ile Pro Glu Val Pro Gly Ser Leu 
                325                 330                 335     


Pro Ala Ser His Lys Tyr Asp Leu Ser Asp Met Gln Ala Val Ala Arg 
            340                 345                 350         


Phe Val Lys Trp Gln Tyr Phe Glu Gly Asp Val Ser Lys Gly Ala Pro 
        355                 360                 365             


Tyr Pro Pro Cys Asp Gly Val His Val Arg Ser Val Cys Ile Phe Gly 
    370                 375                 380                 


Ala Gly Asp Leu Asn Trp Met Leu Arg Lys His His Leu Phe Ala Asn 
385                 390                 395                 400 


Lys Phe Asp Val Asp Val Asp Leu Phe Ala Ile Gln Cys Leu Asp Glu 
                405                 410                 415     


His Leu Arg His Lys Ala Leu Glu Thr Leu Lys His 
            420                 425             


<210>  614
<211>  428
<212>  PRT
<213>  Homo sapiens

<400>  614

Met Leu Arg Thr Leu Leu Arg Arg Arg Leu Phe Ser Tyr Pro Thr Lys 
1               5                   10                  15      


Tyr Tyr Phe Met Val Leu Val Leu Ser Leu Ile Thr Phe Ser Val Leu 
            20                  25                  30          


Arg Ile His Gln Lys Pro Glu Phe Val Ser Val Arg His Leu Glu Leu 
        35                  40                  45              


Ala Gly Glu Asn Pro Ser Ser Asp Ile Asn Cys Thr Lys Val Leu Gln 
    50                  55                  60                  


Gly Asp Val Asn Glu Ile Gln Lys Val Lys Leu Glu Ile Leu Thr Val 
65                  70                  75                  80  


Lys Phe Lys Lys Arg Pro Arg Trp Thr Pro Asp Asp Tyr Ile Asn Met 
                85                  90                  95      


Thr Ser Asp Cys Ser Ser Phe Ile Lys Arg Arg Lys Tyr Ile Val Glu 
            100                 105                 110         


Pro Leu Ser Lys Glu Glu Ala Glu Phe Pro Ile Ala Tyr Ser Ile Val 
        115                 120                 125             


Val His His Lys Ile Glu Met Leu Asp Arg Leu Leu Arg Ala Ile Tyr 
    130                 135                 140                 


Met Pro Gln Asn Phe Tyr Cys Ile His Val Asp Thr Lys Ser Glu Asp 
145                 150                 155                 160 


Ser Tyr Leu Ala Ala Val Met Gly Ile Ala Ser Cys Phe Ser Asn Val 
                165                 170                 175     


Phe Val Ala Ser Arg Leu Glu Ser Val Val Tyr Ala Ser Trp Ser Arg 
            180                 185                 190         


Val Gln Ala Asp Leu Asn Cys Met Lys Asp Leu Tyr Ala Met Ser Ala 
        195                 200                 205             


Asn Trp Lys Tyr Leu Ile Asn Leu Cys Gly Met Asp Phe Pro Ile Lys 
    210                 215                 220                 


Thr Asn Leu Glu Ile Val Arg Lys Leu Lys Leu Leu Met Gly Glu Asn 
225                 230                 235                 240 


Asn Leu Glu Thr Glu Arg Met Pro Ser His Lys Glu Glu Arg Trp Lys 
                245                 250                 255     


Lys Arg Tyr Glu Val Val Asn Gly Lys Leu Thr Asn Thr Gly Thr Val 
            260                 265                 270         


Lys Met Leu Pro Pro Leu Glu Thr Pro Leu Phe Ser Gly Ser Ala Tyr 
        275                 280                 285             


Phe Val Val Ser Arg Glu Tyr Val Gly Tyr Val Leu Gln Asn Glu Lys 
    290                 295                 300                 


Ile Gln Lys Leu Met Glu Trp Ala Gln Asp Thr Tyr Ser Pro Asp Glu 
305                 310                 315                 320 


Tyr Leu Trp Ala Thr Ile Gln Arg Ile Pro Glu Val Pro Gly Ser Leu 
                325                 330                 335     


Pro Ala Ser His Lys Tyr Asp Leu Ser Asp Met Gln Ala Val Ala Arg 
            340                 345                 350         


Phe Val Lys Trp Gln Tyr Phe Glu Gly Asp Val Ser Lys Gly Ala Pro 
        355                 360                 365             


Tyr Pro Pro Cys Asp Gly Val His Val Arg Ser Val Cys Ile Phe Gly 
    370                 375                 380                 


Ala Gly Asp Leu Asn Trp Met Leu Arg Lys His His Leu Phe Ala Asn 
385                 390                 395                 400 


Lys Phe Asp Val Asp Val Asp Leu Phe Ala Ile Gln Cys Leu Asp Glu 
                405                 410                 415     


His Leu Arg His Lys Ala Leu Glu Thr Leu Lys His 
            420                 425             


<210>  615
<211>  219
<212>  PRT
<213>  Homo sapiens

<400>  615

Met Pro Arg Gly Arg Lys Ser Arg Arg Arg Arg Asn Ala Arg Ala Ala 
1               5                   10                  15      


Glu Glu Asn Arg Asn Asn Arg Lys Ile Gln Ala Ser Glu Ala Ser Glu 
            20                  25                  30          


Thr Pro Met Ala Ala Ser Val Val Ala Ser Thr Pro Glu Asp Asp Leu 
        35                  40                  45              


Ser Gly Pro Glu Glu Asp Pro Ser Thr Pro Glu Glu Ala Ser Thr Thr 
    50                  55                  60                  


Pro Glu Glu Ala Ser Ser Thr Ala Gln Ala Gln Lys Pro Ser Val Pro 
65                  70                  75                  80  


Arg Ser Asn Phe Gln Gly Thr Lys Lys Ser Leu Leu Met Ser Ile Leu 
                85                  90                  95      


Ala Leu Ile Phe Ile Met Gly Asn Ser Ala Lys Glu Ala Leu Val Trp 
            100                 105                 110         


Lys Val Leu Gly Lys Leu Gly Met Gln Pro Gly Arg Gln His Ser Ile 
        115                 120                 125             


Phe Gly Asp Pro Lys Lys Ile Val Thr Glu Glu Phe Val Arg Arg Gly 
    130                 135                 140                 


Tyr Leu Ile Tyr Lys Pro Val Pro Arg Ser Ser Pro Val Glu Tyr Glu 
145                 150                 155                 160 


Phe Phe Trp Gly Pro Arg Ala His Val Glu Ser Ser Lys Leu Lys Val 
                165                 170                 175     


Met His Phe Val Ala Arg Val Arg Asn Arg Cys Ser Lys Asp Trp Pro 
            180                 185                 190         


Cys Asn Tyr Asp Trp Asp Ser Asp Asp Asp Ala Glu Val Glu Ala Ile 
        195                 200                 205             


Leu Asn Ser Gly Ala Arg Gly Tyr Ser Ala Pro 
    210                 215                 


<210>  616
<211>  85
<212>  PRT
<213>  Homo sapiens

<400>  616

Met Gly Pro Arg Gln Gly Arg Trp Trp Leu Leu Leu Trp Leu Pro Pro 
1               5                   10                  15      


Leu Ala Thr Leu Pro Val Arg Gly Glu Ala Ala Ala Ala Ala Leu Ser 
            20                  25                  30          


Val Arg Arg Cys Lys Ala Leu Lys Glu Lys Asp Leu Ile Arg Thr Ser 
        35                  40                  45              


Glu Ser Asp Cys Tyr Cys Tyr Asn Gln Asn Ser Gln Val Glu Trp Lys 
    50                  55                  60                  


Tyr Ile Trp Ser Thr Met Gln Gly Asp Cys Val Leu Leu Cys Gly Ala 
65                  70                  75                  80  


Cys Gln Glu Asp Ile 
                85  


<210>  617
<211>  417
<212>  PRT
<213>  Homo sapiens

<400>  617

Met Gly Pro Arg Gln Gly Arg Trp Trp Leu Leu Leu Trp Leu Pro Pro 
1               5                   10                  15      


Leu Ala Thr Leu Pro Val Arg Gly Glu Ala Ala Ala Ala Ala Leu Ser 
            20                  25                  30          


Val Arg Arg Cys Lys Ala Leu Lys Glu Lys Asp Leu Ile Arg Thr Ser 
        35                  40                  45              


Glu Ser Asp Cys Tyr Cys Tyr Asn Gln Asn Ser Gln Val Glu Trp Lys 
    50                  55                  60                  


Tyr Ile Trp Ser Thr Met Gln Val Lys Ile Thr Ser Pro Gly Leu Phe 
65                  70                  75                  80  


Arg Ile Val Tyr Ile Ala Glu Arg His Asn Cys Gln Tyr Pro Glu Asn 
                85                  90                  95      


Ile Leu Ser Phe Ile Lys Cys Val Ile His Asn Phe Trp Ile Pro Lys 
            100                 105                 110         


Glu Ser Asn Glu Ile Thr Ile Ile Ile Asn Pro Tyr Arg Glu Thr Val 
        115                 120                 125             


Cys Phe Ser Val Glu Pro Val Lys Lys Ile Phe Asn Tyr Met Ile His 
    130                 135                 140                 


Val Asn Arg Asn Ile Met Asp Phe Lys Leu Phe Leu Val Phe Val Ala 
145                 150                 155                 160 


Gly Val Phe Leu Phe Phe Tyr Ala Arg Thr Leu Ser Gln Ser Pro Thr 
                165                 170                 175     


Phe Tyr Tyr Ser Ser Gly Thr Val Leu Gly Val Leu Met Thr Leu Val 
            180                 185                 190         


Phe Val Leu Leu Leu Val Lys Arg Phe Ile Pro Lys Tyr Ser Thr Phe 
        195                 200                 205             


Trp Ala Leu Met Val Gly Cys Trp Phe Ala Ser Val Tyr Ile Val Cys 
    210                 215                 220                 


Gln Leu Met Glu Asp Leu Lys Trp Leu Trp Tyr Glu Asn Arg Ile Tyr 
225                 230                 235                 240 


Val Leu Gly Tyr Val Leu Ile Val Gly Phe Phe Ser Phe Val Val Cys 
                245                 250                 255     


Tyr Lys His Gly Pro Leu Ala Asp Asp Arg Ser Arg Ser Leu Leu Met 
            260                 265                 270         


Trp Met Leu Arg Leu Leu Ser Leu Val Leu Val Tyr Ala Gly Val Ala 
        275                 280                 285             


Val Pro Gln Phe Ala Tyr Ala Ala Ile Ile Leu Leu Met Ser Ser Trp 
    290                 295                 300                 


Ser Leu His Tyr Pro Leu Arg Ala Cys Ser Tyr Met Arg Trp Lys Met 
305                 310                 315                 320 


Glu Gln Trp Phe Thr Ser Lys Glu Leu Val Val Lys Tyr Leu Thr Glu 
                325                 330                 335     


Asp Glu Tyr Arg Glu Gln Ala Asp Ala Glu Thr Asn Ser Ala Leu Glu 
            340                 345                 350         


Glu Leu Arg Arg Ala Cys Arg Lys Pro Asp Phe Pro Ser Trp Leu Val 
        355                 360                 365             


Val Ser Arg Leu His Thr Pro Ser Lys Phe Ala Asp Phe Val Leu Gly 
    370                 375                 380                 


Gly Ser His Leu Ser Pro Glu Glu Ile Ser Leu His Glu Glu Gln Tyr 
385                 390                 395                 400 


Gly Leu Gly Gly Ala Phe Leu Glu Glu Gln Leu Phe Asn Pro Ser Thr 
                405                 410                 415     


Ala 
    


<210>  618
<211>  138
<212>  PRT
<213>  Homo sapiens

<400>  618

Met Gln Val Lys Ile Thr Ser Pro Gly Leu Phe Arg Ile Val Tyr Ile 
1               5                   10                  15      


Ala Glu Arg His Asn Cys Gln Tyr Pro Glu Asn Ile Leu Ser Phe Ile 
            20                  25                  30          


Lys Cys Val Ile His Asn Phe Trp Ile Pro Lys Glu Ser Asn Glu Ile 
        35                  40                  45              


Thr Ile Ile Ile Asn Pro Tyr Arg Glu Thr Val Cys Phe Ser Val Glu 
    50                  55                  60                  


Pro Val Lys Lys Ile Phe Asn Tyr Met Ile His Val Asn Arg Asn Ile 
65                  70                  75                  80  


Met Asp Phe Lys Leu Phe Leu Val Phe Val Ala Gly Val Phe Leu Phe 
                85                  90                  95      


Phe Tyr Ala Arg Thr Leu Ser Gln Ser Pro Thr Phe Tyr Tyr Ser Ser 
            100                 105                 110         


Gly Thr Val Leu Gly Val Leu Met Thr Leu Val Phe Val Leu Leu Leu 
        115                 120                 125             


Val Lys Arg Phe Ile Pro Lys Ala Met Ser 
    130                 135             


<210>  619
<211>  24
<212>  PRT
<213>  Homo sapiens

<400>  619

Met Gln Val Lys Ile Thr Ser Pro Gly Leu Phe Arg Ile Val Tyr Ile 
1               5                   10                  15      


Ala Glu Arg His Asn Cys Gln Tyr 
            20                  


<210>  620
<211>  35
<212>  PRT
<213>  Homo sapiens

<400>  620

Asp Cys Tyr Cys Tyr Asn Gln Asn Ser Gln Val Glu Trp Lys Tyr Ile 
1               5                   10                  15      


Trp Ser Thr Met Gln Gly Asp Cys Val Leu Leu Cys Gly Ala Cys Gln 
            20                  25                  30          


Glu Asp Ile 
        35  


<210>  621
<211>  422
<212>  PRT
<213>  Homo sapiens

<400>  621

Met Leu His Leu Leu Ala Leu Phe Leu His Cys Leu Pro Leu Ala Ser 
1               5                   10                  15      


Gly Asp Tyr Asp Ile Cys Lys Ser Trp Val Thr Thr Asp Glu Gly Pro 
            20                  25                  30          


Thr Trp Glu Phe Tyr Ala Cys Gln Pro Lys Val Met Arg Leu Lys Asp 
        35                  40                  45              


Tyr Val Lys Val Lys Val Glu Pro Ser Gly Ile Thr Cys Gly Asp Pro 
    50                  55                  60                  


Pro Glu Arg Phe Cys Ser His Glu Asn Pro Tyr Leu Cys Ser Asn Glu 
65                  70                  75                  80  


Cys Asp Ala Ser Asn Pro Asp Leu Ala His Pro Pro Arg Leu Met Phe 
                85                  90                  95      


Asp Lys Glu Glu Glu Gly Leu Ala Thr Tyr Trp Gln Ser Ile Thr Trp 
            100                 105                 110         


Ser Arg Tyr Pro Ser Pro Leu Glu Ala Asn Ile Thr Leu Ser Trp Asn 
        115                 120                 125             


Lys Thr Val Glu Leu Thr Asp Asp Val Val Met Thr Phe Glu Tyr Gly 
    130                 135                 140                 


Arg Pro Thr Val Met Val Leu Glu Lys Ser Leu Asp Asn Gly Arg Thr 
145                 150                 155                 160 


Trp Gln Pro Tyr Gln Phe Tyr Ala Glu Asp Cys Met Glu Ala Phe Gly 
                165                 170                 175     


Met Ser Ala Arg Arg Ala Arg Asp Met Ser Ser Ser Ser Ala His Arg 
            180                 185                 190         


Val Leu Cys Thr Glu Glu Tyr Ser Arg Trp Ala Gly Ser Lys Lys Glu 
        195                 200                 205             


Lys His Val Arg Phe Glu Val Arg Asp Arg Phe Ala Ile Phe Ala Gly 
    210                 215                 220                 


Pro Asp Leu Arg Asn Met Asp Asn Leu Tyr Thr Arg Leu Glu Ser Ala 
225                 230                 235                 240 


Lys Gly Leu Lys Glu Phe Phe Thr Leu Thr Asp Leu Arg Met Arg Leu 
                245                 250                 255     


Leu Arg Pro Ala Leu Gly Gly Thr Tyr Val Gln Arg Glu Asn Leu Tyr 
            260                 265                 270         


Lys Tyr Phe Tyr Ala Ile Ser Asn Ile Glu Val Ile Gly Arg Cys Lys 
        275                 280                 285             


Cys Asn Leu His Ala Asn Leu Cys Ser Met Arg Glu Gly Ser Leu Gln 
    290                 295                 300                 


Cys Glu Cys Glu His Asn Thr Thr Gly Pro Asp Cys Gly Lys Cys Lys 
305                 310                 315                 320 


Lys Asn Phe Arg Thr Arg Ser Trp Arg Ala Gly Ser Tyr Leu Pro Leu 
                325                 330                 335     


Pro His Gly Ser Pro Asn Ala Cys Ala Thr Ala Gly Ser Phe Gly Thr 
            340                 345                 350         


Leu Gln Thr Pro Pro Pro Gly Arg Ser Pro Ser Ala Leu Arg Gly Ser 
        355                 360                 365             


Arg Arg Gly Leu Ala Asn Val Lys Glu Pro Ala Gly Ser Arg Pro Gln 
    370                 375                 380                 


Ile Ser Glu Met Leu Leu Gly Cys Thr Val Thr Leu His Gln Gly Ser 
385                 390                 395                 400 


Val Gly Pro His Ile Pro Pro Lys Leu Ser Leu Pro Asp Pro Gly Gly 
                405                 410                 415     


Pro Trp Leu Gly Ser Gln 
            420         


<210>  622
<211>  530
<212>  PRT
<213>  Homo sapiens

<400>  622

Met Leu His Leu Leu Ala Leu Phe Leu His Cys Leu Pro Leu Ala Ser 
1               5                   10                  15      


Gly Asp Tyr Asp Ile Cys Lys Ser Trp Val Thr Thr Asp Glu Gly Pro 
            20                  25                  30          


Thr Trp Glu Phe Tyr Ala Cys Gln Pro Lys Val Met Arg Leu Lys Asp 
        35                  40                  45              


Tyr Val Lys Val Lys Val Glu Pro Ser Gly Ile Thr Cys Gly Asp Pro 
    50                  55                  60                  


Pro Glu Arg Phe Cys Ser His Glu Asn Pro Tyr Leu Cys Ser Asn Glu 
65                  70                  75                  80  


Cys Asp Ala Ser Asn Pro Asp Leu Ala His Pro Pro Arg Leu Met Phe 
                85                  90                  95      


Asp Lys Glu Glu Glu Gly Leu Ala Thr Tyr Trp Gln Ser Ile Thr Trp 
            100                 105                 110         


Ser Arg Tyr Pro Ser Pro Leu Glu Ala Asn Ile Thr Leu Ser Trp Asn 
        115                 120                 125             


Lys Thr Val Glu Leu Thr Asp Asp Val Val Met Thr Phe Glu Tyr Gly 
    130                 135                 140                 


Arg Pro Thr Val Met Val Leu Glu Lys Ser Leu Asp Asn Gly Arg Thr 
145                 150                 155                 160 


Trp Gln Pro Tyr Gln Phe Tyr Ala Glu Asp Cys Met Glu Ala Phe Gly 
                165                 170                 175     


Met Ser Ala Arg Arg Ala Arg Asp Met Ser Ser Ser Ser Ala His Arg 
            180                 185                 190         


Val Leu Cys Thr Glu Glu Tyr Ser Arg Trp Ala Gly Ser Lys Lys Glu 
        195                 200                 205             


Lys His Val Arg Phe Glu Val Arg Asp Arg Phe Ala Ile Phe Ala Gly 
    210                 215                 220                 


Pro Asp Leu Arg Asn Met Asp Asn Leu Tyr Thr Arg Leu Glu Ser Ala 
225                 230                 235                 240 


Lys Gly Leu Lys Glu Phe Phe Thr Leu Thr Asp Leu Arg Met Arg Leu 
                245                 250                 255     


Leu Arg Pro Ala Leu Gly Gly Thr Tyr Val Gln Arg Glu Asn Leu Tyr 
            260                 265                 270         


Lys Tyr Phe Tyr Ala Ile Ser Asn Ile Glu Val Ile Gly Arg Cys Lys 
        275                 280                 285             


Cys Asn Leu His Ala Asn Leu Cys Ser Met Arg Glu Gly Ser Leu Gln 
    290                 295                 300                 


Cys Glu Cys Glu His Asn Thr Thr Gly Pro Asp Cys Gly Lys Cys Lys 
305                 310                 315                 320 


Lys Asn Phe Arg Thr Arg Ser Trp Arg Ala Gly Ser Tyr Leu Pro Leu 
                325                 330                 335     


Pro His Gly Ser Pro Asn Ala Cys Ala Thr Ala Gly Ser Phe Gly Asn 
            340                 345                 350         


Cys Glu Cys Tyr Gly His Ser Asn Arg Cys Ser Tyr Ile Asp Phe Leu 
        355                 360                 365             


Asn Val Val Thr Cys Val Ser Cys Lys His Asn Thr Arg Gly Gln His 
    370                 375                 380                 


Cys Gln His Cys Arg Leu Gly Tyr Tyr Arg Asn Gly Ser Ala Glu Leu 
385                 390                 395                 400 


Asp Asp Glu Asn Val Cys Ile Glu Cys Asn Cys Asn Gln Ile Gly Ser 
                405                 410                 415     


Val His Asp Arg Cys Asn Glu Thr Gly Phe Cys Glu Cys Arg Glu Gly 
            420                 425                 430         


Ala Ala Gly Pro Lys Cys Asp Asp Cys Leu Pro Thr His Tyr Trp Arg 
        435                 440                 445             


Gln Gly Cys Tyr Pro Asn Val Cys Asp Asp Asp Gln Leu Leu Cys Gln 
    450                 455                 460                 


Asn Gly Gly Thr Cys Leu Gln Asn Gln Arg Cys Ala Cys Pro Arg Gly 
465                 470                 475                 480 


Tyr Thr Gly Val Arg Cys Glu Gln Pro Arg Cys Asp Pro Ala Asp Asp 
                485                 490                 495     


Asp Gly Gly Leu Asp Cys Asp Arg Ala Pro Gly Ala Ala Pro Arg Pro 
            500                 505                 510         


Ala Thr Leu Leu Gly Cys Leu Leu Leu Leu Gly Leu Ala Ala Arg Leu 
        515                 520                 525             


Gly Arg 
    530 


<210>  623
<211>  211
<212>  PRT
<213>  Homo sapiens

<400>  623

Met Arg Thr Leu Ala Cys Leu Leu Leu Leu Gly Cys Gly Tyr Leu Ala 
1               5                   10                  15      


His Val Leu Ala Glu Glu Ala Glu Ile Pro Arg Glu Val Ile Glu Arg 
            20                  25                  30          


Leu Ala Arg Ser Gln Ile His Ser Ile Arg Asp Leu Gln Arg Leu Leu 
        35                  40                  45              


Glu Ile Asp Ser Val Gly Ser Glu Asp Ser Leu Asp Thr Ser Leu Arg 
    50                  55                  60                  


Ala His Gly Val His Ala Thr Lys His Val Pro Glu Lys Arg Pro Leu 
65                  70                  75                  80  


Pro Ile Arg Arg Lys Arg Ser Ile Glu Glu Ala Val Pro Ala Val Cys 
                85                  90                  95      


Lys Thr Arg Thr Val Ile Tyr Glu Ile Pro Arg Ser Gln Val Asp Pro 
            100                 105                 110         


Thr Ser Ala Asn Phe Leu Ile Trp Pro Pro Cys Val Glu Val Lys Arg 
        115                 120                 125             


Cys Thr Gly Cys Cys Asn Thr Ser Ser Val Lys Cys Gln Pro Ser Arg 
    130                 135                 140                 


Val His His Arg Ser Val Lys Val Ala Lys Val Glu Tyr Val Arg Lys 
145                 150                 155                 160 


Lys Pro Lys Leu Lys Glu Val Gln Val Arg Leu Glu Glu His Leu Glu 
                165                 170                 175     


Cys Ala Cys Ala Thr Thr Ser Leu Asn Pro Asp Tyr Arg Glu Glu Asp 
            180                 185                 190         


Thr Gly Arg Pro Arg Glu Ser Gly Lys Lys Arg Lys Arg Lys Arg Leu 
        195                 200                 205             


Lys Pro Thr 
    210     


<210>  624
<211>  205
<212>  PRT
<213>  Homo sapiens

<400>  624

Gln Arg Gln Ala Ala Ala Leu Gly Ser Gln Ser Pro Ser Pro Ala Gly 
1               5                   10                  15      


Leu Arg Ala Gly Ala Val Pro Pro Ala Arg Ala Cys Leu Gln Glu Ala 
            20                  25                  30          


Glu Ile Pro Arg Glu Val Ile Glu Arg Leu Ala Arg Ser Gln Ile His 
        35                  40                  45              


Ser Ile Arg Asp Leu Gln Arg Leu Leu Glu Ile Asp Ser Val Gly Ser 
    50                  55                  60                  


Glu Asp Ser Leu Asp Thr Ser Leu Arg Ala His Gly Val His Ala Thr 
65                  70                  75                  80  


Lys His Val Pro Glu Lys Arg Pro Leu Pro Ile Arg Arg Lys Arg Ser 
                85                  90                  95      


Ile Glu Glu Ala Val Pro Ala Val Cys Lys Thr Arg Thr Val Ile Tyr 
            100                 105                 110         


Glu Ile Pro Arg Ser Gln Val Asp Pro Thr Ser Ala Asn Phe Leu Ile 
        115                 120                 125             


Trp Pro Pro Cys Val Glu Val Lys Arg Cys Thr Gly Cys Cys Asn Thr 
    130                 135                 140                 


Ser Ser Val Lys Cys Gln Pro Ser Arg Val His His Arg Ser Val Lys 
145                 150                 155                 160 


Val Ala Lys Val Glu Tyr Val Arg Lys Lys Pro Lys Leu Lys Glu Val 
                165                 170                 175     


Gln Val Arg Leu Glu Glu His Leu Glu Cys Ala Cys Ala Thr Thr Ser 
            180                 185                 190         


Leu Asn Pro Asp Tyr Arg Glu Glu Asp Thr Asp Val Arg 
        195                 200                 205 


<210>  625
<211>  196
<212>  PRT
<213>  Homo sapiens

<400>  625

Met Arg Thr Leu Ala Cys Leu Leu Leu Leu Gly Cys Gly Tyr Leu Ala 
1               5                   10                  15      


His Val Leu Ala Glu Glu Ala Glu Ile Pro Arg Glu Val Ile Glu Arg 
            20                  25                  30          


Leu Ala Arg Ser Gln Ile His Ser Ile Arg Asp Leu Gln Arg Leu Leu 
        35                  40                  45              


Glu Ile Asp Ser Val Gly Ser Glu Asp Ser Leu Asp Thr Ser Leu Arg 
    50                  55                  60                  


Ala His Gly Val His Ala Thr Lys His Val Pro Glu Lys Arg Pro Leu 
65                  70                  75                  80  


Pro Ile Arg Arg Lys Arg Ser Ile Glu Glu Ala Val Pro Ala Val Cys 
                85                  90                  95      


Lys Thr Arg Thr Val Ile Tyr Glu Ile Pro Arg Ser Gln Val Asp Pro 
            100                 105                 110         


Thr Ser Ala Asn Phe Leu Ile Trp Pro Pro Cys Val Glu Val Lys Arg 
        115                 120                 125             


Cys Thr Gly Cys Cys Asn Thr Ser Ser Val Lys Cys Gln Pro Ser Arg 
    130                 135                 140                 


Val His His Arg Ser Val Lys Val Ala Lys Val Glu Tyr Val Arg Lys 
145                 150                 155                 160 


Lys Pro Lys Leu Lys Glu Val Gln Val Arg Leu Glu Glu His Leu Glu 
                165                 170                 175     


Cys Ala Cys Ala Thr Thr Ser Leu Asn Pro Asp Tyr Arg Glu Glu Asp 
            180                 185                 190         


Thr Asp Val Arg 
        195     


<210>  626
<211>  86
<212>  PRT
<213>  Homo sapiens

<400>  626

Met Arg Thr Leu Ala Cys Leu Leu Leu Leu Gly Cys Gly Tyr Leu Ala 
1               5                   10                  15      


His Val Leu Ala Glu Glu Ala Glu Ile Pro Arg Glu Val Ile Glu Arg 
            20                  25                  30          


Leu Ala Arg Ser Gln Ile His Ser Ile Arg Asp Leu Gln Arg Leu Leu 
        35                  40                  45              


Glu Ile Asp Ser Val Gly Ser Glu Asp Ser Leu Asp Thr Ser Leu Arg 
    50                  55                  60                  


Ala His Gly Val His Ala Thr Lys His Val Pro Glu Lys Arg Pro Leu 
65                  70                  75                  80  


Pro Ile Arg Arg Lys Arg 
                85      


<210>  627
<211>  273
<212>  PRT
<213>  Homo sapiens

<400>  627

Met Ile Phe Leu Leu Leu Met Leu Ser Leu Glu Leu Gln Leu His Gln 
1               5                   10                  15      


Ile Ala Ala Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile 
            20                  25                  30          


Glu His Gly Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser 
        35                  40                  45              


His Val Asn Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn 
    50                  55                  60                  


Asp Thr Ser Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu 
65                  70                  75                  80  


Pro Leu Gly Lys Ala Ser Phe His Ile Pro Gln Val Gln Val Arg Asp 
                85                  90                  95      


Glu Gly Gln Tyr Gln Cys Ile Ile Ile Tyr Gly Val Ala Trp Asp Tyr 
            100                 105                 110         


Lys Tyr Leu Thr Leu Lys Val Lys Ala Ser Tyr Arg Lys Ile Asn Thr 
        115                 120                 125             


His Ile Leu Lys Val Pro Glu Thr Asp Glu Val Glu Leu Thr Cys Gln 
    130                 135                 140                 


Ala Thr Gly Tyr Pro Leu Ala Glu Val Ser Trp Pro Asn Val Ser Val 
145                 150                 155                 160 


Pro Ala Asn Thr Ser His Ser Arg Thr Pro Glu Gly Leu Tyr Gln Val 
                165                 170                 175     


Thr Ser Val Leu Arg Leu Lys Pro Pro Pro Gly Arg Asn Phe Ser Cys 
            180                 185                 190         


Val Phe Trp Asn Thr His Val Arg Glu Leu Thr Leu Ala Ser Ile Asp 
        195                 200                 205             


Leu Gln Ser Gln Met Glu Pro Arg Thr His Pro Thr Trp Leu Leu His 
    210                 215                 220                 


Ile Phe Ile Pro Phe Cys Ile Ile Ala Phe Ile Phe Ile Ala Thr Val 
225                 230                 235                 240 


Ile Ala Leu Arg Lys Gln Leu Cys Gln Lys Leu Tyr Ser Ser Lys Asp 
                245                 250                 255     


Thr Thr Lys Arg Pro Val Thr Thr Thr Lys Arg Glu Val Asn Ser Ala 
            260                 265                 270         


Ile 
    


<210>  628
<211>  423
<212>  PRT
<213>  Homo sapiens

<400>  628

Met Asp Arg Gly Gln Pro Ser Leu Glu Pro Ala Ala Ala Ala Pro Arg 
1               5                   10                  15      


Ala Ser Gly Arg Cys Val Ile Ala Pro Val Arg Ala Val Leu Arg Leu 
            20                  25                  30          


Arg Arg Arg Val Cys Val Leu Arg Lys Arg Arg Leu Leu Gln Pro Gly 
        35                  40                  45              


Gly Gly Pro Asp Val Gly Thr Gly Ala Pro Arg Pro Gly Cys Ser Pro 
    50                  55                  60                  


Arg Ala Pro Arg Ala Asp Leu Asp Gln Pro Lys Phe Phe Thr Phe Asp 
65                  70                  75                  80  


Ser Pro Ala Glu Leu Pro Ser Arg Thr Pro Arg Lys Lys Arg Arg Arg 
                85                  90                  95      


Ser Arg Leu Val Leu Tyr Pro Glu Thr Ser Arg Lys Tyr Arg Pro Arg 
            100                 105                 110         


Val Glu His Arg Ser Arg Ala Gln Arg Cys Leu Leu Leu Leu Val Ala 
        115                 120                 125             


Ile Val Gly Phe Gln Val Leu Asn Ala Ile Glu Asn Leu Asp Asp Asn 
    130                 135                 140                 


Ala Gln Arg Tyr Asp Leu Asp Gly Leu Glu Lys Ala Leu Gln Arg Ala 
145                 150                 155                 160 


Val Phe Gly Gln Pro Ala Ala Val Ser Arg Ile Val Ala Leu Met Arg 
                165                 170                 175     


Asp Tyr Leu Ala Thr His Val His Ser Arg Pro Leu Leu Leu Ala Leu 
            180                 185                 190         


His Gly Pro Ser Gly Val Gly Lys Ser His Val Gly Arg Leu Leu Ala 
        195                 200                 205             


Arg His Phe Arg Ser Val Leu Glu Asp Ser Ala Leu Val Leu Gln Tyr 
    210                 215                 220                 


His Ala Arg His His Cys Pro Glu Ala Arg Ala Ala Gln Asp Cys Arg 
225                 230                 235                 240 


Glu Glu Leu Ala Arg Arg Val Ala Asp Val Val Ala Arg Ala Glu Ala 
                245                 250                 255     


Glu Glu Lys Thr Pro Leu Leu Val Leu Asp Asp Val Glu Leu Met Pro 
            260                 265                 270         


Arg Pro Leu Leu Asp Glu Leu His Gly Phe Leu Gln Pro Gln Arg Ser 
        275                 280                 285             


His His Phe His Asn Ala Ile Tyr Val Leu Leu Ser Gly Ala Gly Gly 
    290                 295                 300                 


Ala Glu Val Thr Arg Phe Val Leu Gln Asn Ala Ser Arg Ala Leu Pro 
305                 310                 315                 320 


Leu Arg Pro Asp Gly Phe Arg Ser Ala Glu Ala Ala Ala Ala Gln Ala 
                325                 330                 335     


Glu Glu Asp Leu Arg Ala Ser Leu Leu Ala Val Leu Ser Arg Glu His 
            340                 345                 350         


Pro Leu Trp Gln Ala Ala Ala Ile Val Pro Phe Leu Leu Leu Asp Lys 
        355                 360                 365             


Arg Asp Val Val Ser Cys Phe Arg Asp Glu Met Ala Gly Glu Gly Phe 
    370                 375                 380                 


Phe Pro Asp Gln Ala Arg Ala Glu Asn Leu Ala Ala Gln Leu Ser Phe 
385                 390                 395                 400 


Tyr Arg Val Ala Gly Arg Glu Phe Ala Val Thr Gly Cys Lys Gln Val 
                405                 410                 415     


Val Ala Thr Val Asn Leu Leu 
            420             


<210>  629
<211>  69
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  629

Xaa Ile Ser Glu Ala Glu Lys Ala Lys Gln Lys Ile Ala Pro Val Phe 
1               5                   10                  15      


Phe Arg Glu Glu Tyr Met Leu Asn Asn Ala Val Gly Ser Cys Gln Lys 
            20                  25                  30          


Pro Tyr Val Ala Leu Ile His Gly Ile Thr Met Gly Gly Asp Cys Ser 
        35                  40                  45              


Leu Met Trp Val Glu Val Ile Ser Cys His Asp Ser Lys Glu Asn Leu 
    50                  55                  60                  


Val Thr Ser Leu His 
65                  


<210>  630
<211>  52
<212>  PRT
<213>  Homo sapiens

<400>  630

Asp Val Gly Gly Gly Tyr Phe Leu Pro Arg Leu Gln Gly Lys Leu Gly 
1               5                   10                  15      


Tyr Phe Leu Ala Leu Thr Gly Phe Arg Leu Lys Gly Arg Asp Val Tyr 
            20                  25                  30          


Arg Ala Gly Ile Ala Thr His Phe Val Asp Ser Glu Lys Asn Gly Asp 
        35                  40                  45              


Asp Thr Ile Thr 
    50          


<210>  631
<211>  793
<212>  PRT
<213>  Homo sapiens

<400>  631

Met Leu Arg Gly Gly Arg Arg Gly Gln Leu Gly Trp His Ser Trp Ala 
1               5                   10                  15      


Ala Gly Pro Gly Ser Leu Leu Ala Trp Leu Ile Leu Ala Ser Ala Gly 
            20                  25                  30          


Ala Ala Pro Cys Pro Asp Ala Cys Cys Pro His Gly Ser Ser Gly Leu 
        35                  40                  45              


Arg Cys Thr Arg Asp Gly Ala Leu Asp Ser Leu His His Leu Pro Gly 
    50                  55                  60                  


Ala Glu Asn Leu Thr Glu Leu Tyr Ile Glu Asn Gln Gln His Leu Gln 
65                  70                  75                  80  


His Leu Glu Leu Arg Asp Leu Arg Gly Leu Gly Glu Leu Arg Asn Leu 
                85                  90                  95      


Thr Ile Val Lys Ser Gly Leu Arg Phe Val Ala Pro Asp Ala Phe His 
            100                 105                 110         


Phe Thr Pro Arg Leu Ser Arg Leu Asn Leu Ser Phe Asn Ala Leu Glu 
        115                 120                 125             


Ser Leu Ser Trp Lys Thr Val Gln Gly Leu Ser Leu Gln Glu Leu Val 
    130                 135                 140                 


Leu Ser Gly Asn Pro Leu His Cys Ser Cys Ala Leu Arg Trp Leu Gln 
145                 150                 155                 160 


Arg Trp Glu Glu Glu Gly Leu Gly Gly Val Pro Glu Gln Lys Leu Gln 
                165                 170                 175     


Cys His Gly Gln Gly Pro Leu Ala His Met Pro Asn Ala Ser Cys Gly 
            180                 185                 190         


Val Pro Thr Leu Lys Val Gln Val Pro Asn Ala Ser Val Asp Val Gly 
        195                 200                 205             


Asp Asp Val Leu Leu Arg Cys Gln Val Glu Gly Arg Gly Leu Glu Gln 
    210                 215                 220                 


Ala Gly Trp Ile Leu Thr Glu Leu Glu Gln Ser Ala Thr Val Met Lys 
225                 230                 235                 240 


Ser Gly Gly Leu Pro Ser Leu Gly Leu Thr Leu Ala Asn Val Thr Ser 
                245                 250                 255     


Asp Leu Asn Arg Lys Asn Val Thr Cys Trp Ala Glu Asn Asp Val Gly 
            260                 265                 270         


Arg Ala Glu Val Ser Val Gln Val Asn Val Ser Phe Pro Ala Ser Val 
        275                 280                 285             


Gln Leu His Thr Ala Val Glu Met His His Trp Cys Ile Pro Phe Ser 
    290                 295                 300                 


Val Asp Gly Gln Pro Ala Pro Ser Leu Arg Trp Leu Phe Asn Gly Ser 
305                 310                 315                 320 


Val Leu Asn Glu Thr Ser Phe Ile Phe Thr Glu Phe Leu Glu Pro Ala 
                325                 330                 335     


Ala Asn Glu Thr Val Arg His Gly Cys Leu Arg Leu Asn Gln Pro Thr 
            340                 345                 350         


His Val Asn Asn Gly Asn Tyr Thr Leu Leu Ala Ala Asn Pro Phe Gly 
        355                 360                 365             


Gln Ala Ser Ala Ser Ile Met Ala Ala Phe Met Asp Asn Pro Phe Glu 
    370                 375                 380                 


Phe Asn Pro Glu Asp Pro Ile Pro Asp Thr Asn Ser Thr Ser Gly Asp 
385                 390                 395                 400 


Pro Val Glu Lys Lys Asp Glu Thr Pro Phe Gly Val Ser Val Ala Val 
                405                 410                 415     


Gly Leu Ala Val Phe Ala Cys Leu Phe Leu Ser Thr Leu Leu Leu Val 
            420                 425                 430         


Leu Asn Lys Cys Gly Arg Arg Asn Lys Phe Gly Ile Asn Arg Pro Ala 
        435                 440                 445             


Val Leu Ala Pro Glu Asp Gly Leu Ala Met Ser Leu His Phe Met Thr 
    450                 455                 460                 


Leu Gly Gly Ser Ser Leu Ser Pro Thr Glu Gly Lys Gly Ser Gly Leu 
465                 470                 475                 480 


Gln Gly His Ile Ile Glu Asn Pro Gln Tyr Phe Ser Asp Ala Ser Pro 
                485                 490                 495     


Ser Gly Val His His Ile Lys Arg Arg Asp Ile Val Leu Lys Trp Glu 
            500                 505                 510         


Leu Gly Glu Gly Ala Phe Gly Lys Val Phe Leu Ala Glu Cys His Asn 
        515                 520                 525             


Leu Leu Pro Glu Gln Asp Lys Met Leu Val Ala Val Lys Ala Leu Lys 
    530                 535                 540                 


Glu Ala Ser Glu Ser Ala Arg Gln Asp Phe Gln Arg Glu Ala Glu Leu 
545                 550                 555                 560 


Leu Thr Met Leu Gln His Gln His Ile Val Arg Phe Phe Gly Val Cys 
                565                 570                 575     


Thr Glu Gly Arg Pro Leu Leu Met Val Phe Glu Tyr Met Arg His Gly 
            580                 585                 590         


Asp Leu Asn Arg Phe Leu Arg Ser His Gly Pro Asp Ala Lys Leu Leu 
        595                 600                 605             


Ala Gly Gly Glu Asp Val Ala Pro Gly Pro Leu Gly Leu Gly Gln Leu 
    610                 615                 620                 


Leu Ala Val Ala Ser Gln Val Ala Ala Gly Met Val Tyr Leu Ala Gly 
625                 630                 635                 640 


Leu His Phe Val His Arg Asp Leu Ala Thr Arg Asn Cys Leu Val Gly 
                645                 650                 655     


Gln Gly Leu Val Val Lys Ile Gly Asp Phe Gly Met Ser Arg Asp Ile 
            660                 665                 670         


Tyr Ser Thr Asp Tyr Tyr Arg Val Gly Gly Arg Thr Met Leu Pro Ile 
        675                 680                 685             


Arg Trp Met Pro Pro Glu Ser Ile Leu Tyr Arg Lys Phe Thr Thr Glu 
    690                 695                 700                 


Ser Asp Val Trp Ser Phe Gly Val Val Leu Trp Glu Ile Phe Thr Tyr 
705                 710                 715                 720 


Gly Lys Gln Pro Trp Tyr Gln Leu Ser Asn Thr Glu Ala Ile Asp Cys 
                725                 730                 735     


Ile Thr Gln Gly Arg Glu Leu Glu Arg Pro Arg Ala Cys Pro Pro Glu 
            740                 745                 750         


Val Tyr Ala Ile Met Arg Gly Cys Trp Gln Arg Glu Pro Gln Gln Arg 
        755                 760                 765             


His Ser Ile Lys Asp Val His Ala Arg Leu Gln Ala Leu Ala Gln Ala 
    770                 775                 780                 


Pro Pro Val Tyr Leu Asp Val Leu Gly 
785                 790             


<210>  632
<211>  790
<212>  PRT
<213>  Homo sapiens

<400>  632

Met Leu Arg Gly Gly Arg Arg Gly Gln Leu Gly Trp His Ser Trp Ala 
1               5                   10                  15      


Ala Gly Pro Gly Ser Leu Leu Ala Trp Leu Ile Leu Ala Ser Ala Gly 
            20                  25                  30          


Ala Ala Pro Cys Pro Asp Ala Cys Cys Pro His Gly Ser Ser Gly Leu 
        35                  40                  45              


Arg Cys Thr Arg Asp Gly Ala Leu Asp Ser Leu His His Leu Pro Gly 
    50                  55                  60                  


Ala Glu Asn Leu Thr Glu Leu Tyr Ile Glu Asn Gln Gln His Leu Gln 
65                  70                  75                  80  


His Leu Glu Leu Arg Asp Leu Arg Gly Leu Gly Glu Leu Arg Asn Leu 
                85                  90                  95      


Thr Ile Val Lys Ser Gly Leu Arg Phe Val Ala Pro Asp Ala Phe His 
            100                 105                 110         


Phe Thr Pro Arg Leu Ser Arg Leu Asn Leu Ser Phe Asn Ala Leu Glu 
        115                 120                 125             


Ser Leu Ser Trp Lys Thr Val Gln Gly Leu Ser Leu Gln Glu Leu Val 
    130                 135                 140                 


Leu Ser Gly Asn Pro Leu His Cys Ser Cys Ala Leu Arg Trp Leu Gln 
145                 150                 155                 160 


Arg Trp Glu Glu Glu Gly Leu Gly Gly Val Pro Glu Gln Lys Leu Gln 
                165                 170                 175     


Cys His Gly Gln Gly Pro Leu Ala His Met Pro Asn Ala Ser Cys Gly 
            180                 185                 190         


Val Pro Thr Leu Lys Val Gln Val Pro Asn Ala Ser Val Asp Val Gly 
        195                 200                 205             


Asp Asp Val Leu Leu Arg Cys Gln Val Glu Gly Arg Gly Leu Glu Gln 
    210                 215                 220                 


Ala Gly Trp Ile Leu Thr Glu Leu Glu Gln Ser Ala Thr Val Met Lys 
225                 230                 235                 240 


Ser Gly Gly Leu Pro Ser Leu Gly Leu Thr Leu Ala Asn Val Thr Ser 
                245                 250                 255     


Asp Leu Asn Arg Lys Asn Val Thr Cys Trp Ala Glu Asn Asp Val Gly 
            260                 265                 270         


Arg Ala Glu Val Ser Val Gln Val Asn Val Ser Phe Pro Ala Ser Val 
        275                 280                 285             


Gln Leu His Thr Ala Val Glu Met His His Trp Cys Ile Pro Phe Ser 
    290                 295                 300                 


Val Asp Gly Gln Pro Ala Pro Ser Leu Arg Trp Leu Phe Asn Gly Ser 
305                 310                 315                 320 


Val Leu Asn Glu Thr Ser Phe Ile Phe Thr Glu Phe Leu Glu Pro Ala 
                325                 330                 335     


Ala Asn Glu Thr Val Arg His Gly Cys Leu Arg Leu Asn Gln Pro Thr 
            340                 345                 350         


His Val Asn Asn Gly Asn Tyr Thr Leu Leu Ala Ala Asn Pro Phe Gly 
        355                 360                 365             


Gln Ala Ser Ala Ser Ile Met Ala Ala Phe Met Asp Asn Pro Phe Glu 
    370                 375                 380                 


Phe Asn Pro Glu Asp Pro Ile Pro Asp Thr Asn Ser Thr Ser Gly Asp 
385                 390                 395                 400 


Pro Val Glu Lys Lys Asp Glu Thr Pro Phe Gly Val Ser Val Ala Val 
                405                 410                 415     


Gly Leu Ala Val Phe Ala Cys Leu Phe Leu Ser Thr Leu Leu Leu Val 
            420                 425                 430         


Leu Asn Lys Cys Gly Arg Arg Asn Lys Phe Gly Ile Asn Arg Pro Ala 
        435                 440                 445             


Val Leu Ala Pro Glu Asp Gly Leu Ala Met Ser Leu His Phe Met Thr 
    450                 455                 460                 


Leu Gly Gly Ser Ser Leu Ser Pro Thr Glu Gly Lys Gly Ser Gly Leu 
465                 470                 475                 480 


Gln Gly His Ile Ile Glu Asn Pro Gln Tyr Phe Ser Asp Ala Cys Val 
                485                 490                 495     


His His Ile Lys Arg Arg Asp Ile Val Leu Lys Trp Glu Leu Gly Glu 
            500                 505                 510         


Gly Ala Phe Gly Lys Val Phe Leu Ala Glu Cys His Asn Leu Leu Pro 
        515                 520                 525             


Glu Gln Asp Lys Met Leu Val Ala Val Lys Ala Leu Lys Glu Ala Ser 
    530                 535                 540                 


Glu Ser Ala Arg Gln Asp Phe Gln Arg Glu Ala Glu Leu Leu Thr Met 
545                 550                 555                 560 


Leu Gln His Gln His Ile Val Arg Phe Phe Gly Val Cys Thr Glu Gly 
                565                 570                 575     


Arg Pro Leu Leu Met Val Phe Glu Tyr Met Arg His Gly Asp Leu Asn 
            580                 585                 590         


Arg Phe Leu Arg Ser His Gly Pro Asp Ala Lys Leu Leu Ala Gly Gly 
        595                 600                 605             


Glu Asp Val Ala Pro Gly Pro Leu Gly Leu Gly Gln Leu Leu Ala Val 
    610                 615                 620                 


Ala Ser Gln Val Ala Ala Gly Met Val Tyr Leu Ala Gly Leu His Phe 
625                 630                 635                 640 


Val His Arg Asp Leu Ala Thr Arg Asn Cys Leu Val Gly Gln Gly Leu 
                645                 650                 655     


Val Val Lys Ile Gly Asp Phe Gly Met Ser Arg Asp Ile Tyr Ser Thr 
            660                 665                 670         


Asp Tyr Tyr Arg Val Gly Gly Arg Thr Met Leu Pro Ile Arg Trp Met 
        675                 680                 685             


Pro Pro Glu Ser Ile Leu Tyr Arg Lys Phe Thr Thr Glu Ser Asp Val 
    690                 695                 700                 


Trp Ser Phe Gly Val Val Leu Trp Glu Ile Phe Thr Tyr Gly Lys Gln 
705                 710                 715                 720 


Pro Trp Tyr Gln Leu Ser Asn Thr Glu Ala Ile Asp Cys Ile Thr Gln 
                725                 730                 735     


Gly Arg Glu Leu Glu Arg Pro Arg Ala Cys Pro Pro Glu Val Tyr Ala 
            740                 745                 750         


Ile Met Arg Gly Cys Trp Gln Arg Glu Pro Gln Gln Arg His Ser Ile 
        755                 760                 765             


Lys Asp Val His Ala Arg Leu Gln Ala Leu Ala Gln Ala Pro Pro Val 
    770                 775                 780                 


Tyr Leu Asp Val Leu Gly 
785                 790 


<210>  633
<211>  760
<212>  PRT
<213>  Homo sapiens

<400>  633

Met Lys Glu Ala Ala Leu Ile Cys Leu Ala Pro Ser Val Pro Pro Ile 
1               5                   10                  15      


Leu Thr Val Lys Ser Trp Asp Thr Met Gln Leu Arg Ala Ala Arg Ser 
            20                  25                  30          


Arg Cys Thr Asn Leu Leu Ala Ala Ser Tyr Ile Glu Asn Gln Gln His 
        35                  40                  45              


Leu Gln His Leu Glu Leu Arg Asp Leu Arg Gly Leu Gly Glu Leu Arg 
    50                  55                  60                  


Asn Leu Thr Ile Val Lys Ser Gly Leu Arg Phe Val Ala Pro Asp Ala 
65                  70                  75                  80  


Phe His Phe Thr Pro Arg Leu Ser Arg Leu Asn Leu Ser Phe Asn Ala 
                85                  90                  95      


Leu Glu Ser Leu Ser Trp Lys Thr Val Gln Gly Leu Ser Leu Gln Glu 
            100                 105                 110         


Leu Val Leu Ser Gly Asn Pro Leu His Cys Ser Cys Ala Leu Arg Trp 
        115                 120                 125             


Leu Gln Arg Trp Glu Glu Glu Gly Leu Gly Gly Val Pro Glu Gln Lys 
    130                 135                 140                 


Leu Gln Cys His Gly Gln Gly Pro Leu Ala His Met Pro Asn Ala Ser 
145                 150                 155                 160 


Cys Gly Val Pro Thr Leu Lys Val Gln Val Pro Asn Ala Ser Val Asp 
                165                 170                 175     


Val Gly Asp Asp Val Leu Leu Arg Cys Gln Val Glu Gly Arg Gly Leu 
            180                 185                 190         


Glu Gln Ala Gly Trp Ile Leu Thr Glu Leu Glu Gln Ser Ala Thr Val 
        195                 200                 205             


Met Lys Ser Gly Gly Leu Pro Ser Leu Gly Leu Thr Leu Ala Asn Val 
    210                 215                 220                 


Thr Ser Asp Leu Asn Arg Lys Asn Val Thr Cys Trp Ala Glu Asn Asp 
225                 230                 235                 240 


Val Gly Arg Ala Glu Val Ser Val Gln Val Asn Val Ser Phe Pro Ala 
                245                 250                 255     


Ser Val Gln Leu His Thr Ala Val Glu Met His His Trp Cys Ile Pro 
            260                 265                 270         


Phe Ser Val Asp Gly Gln Pro Ala Pro Ser Leu Arg Trp Leu Phe Asn 
        275                 280                 285             


Gly Ser Val Leu Asn Glu Thr Ser Phe Ile Phe Thr Glu Phe Leu Glu 
    290                 295                 300                 


Pro Ala Ala Asn Glu Thr Val Arg His Gly Cys Leu Arg Leu Asn Gln 
305                 310                 315                 320 


Pro Thr His Val Asn Asn Gly Asn Tyr Thr Leu Leu Ala Ala Asn Pro 
                325                 330                 335     


Phe Gly Gln Ala Ser Ala Ser Ile Met Ala Ala Phe Met Asp Asn Pro 
            340                 345                 350         


Phe Glu Phe Asn Pro Glu Asp Pro Ile Pro Asp Thr Asn Ser Thr Ser 
        355                 360                 365             


Gly Asp Pro Val Glu Lys Lys Asp Glu Thr Pro Phe Gly Val Ser Val 
    370                 375                 380                 


Ala Val Gly Leu Ala Val Phe Ala Cys Leu Phe Leu Ser Thr Leu Leu 
385                 390                 395                 400 


Leu Val Leu Asn Lys Cys Gly Arg Arg Asn Lys Phe Gly Ile Asn Arg 
                405                 410                 415     


Pro Ala Val Leu Ala Pro Glu Asp Gly Leu Ala Met Ser Leu His Phe 
            420                 425                 430         


Met Thr Leu Gly Gly Ser Ser Leu Ser Pro Thr Glu Gly Lys Gly Ser 
        435                 440                 445             


Gly Leu Gln Gly His Ile Ile Glu Asn Pro Gln Tyr Phe Ser Asp Ala 
    450                 455                 460                 


Cys Val His His Ile Lys Arg Arg Asp Ile Val Leu Lys Trp Glu Leu 
465                 470                 475                 480 


Gly Glu Gly Ala Phe Gly Lys Val Phe Leu Ala Glu Cys His Asn Leu 
                485                 490                 495     


Leu Pro Glu Gln Asp Lys Met Leu Val Ala Val Lys Ala Leu Lys Glu 
            500                 505                 510         


Ala Ser Glu Ser Ala Arg Gln Asp Phe Gln Arg Glu Ala Glu Leu Leu 
        515                 520                 525             


Thr Met Leu Gln His Gln His Ile Val Arg Phe Phe Gly Val Cys Thr 
    530                 535                 540                 


Glu Gly Arg Pro Leu Leu Met Val Phe Glu Tyr Met Arg His Gly Asp 
545                 550                 555                 560 


Leu Asn Arg Phe Leu Arg Ser His Gly Pro Asp Ala Lys Leu Leu Ala 
                565                 570                 575     


Gly Gly Glu Asp Val Ala Pro Gly Pro Leu Gly Leu Gly Gln Leu Leu 
            580                 585                 590         


Ala Val Ala Ser Gln Val Ala Ala Gly Met Val Tyr Leu Ala Gly Leu 
        595                 600                 605             


His Phe Val His Arg Asp Leu Ala Thr Arg Asn Cys Leu Val Gly Gln 
    610                 615                 620                 


Gly Leu Val Val Lys Ile Gly Asp Phe Gly Met Ser Arg Asp Ile Tyr 
625                 630                 635                 640 


Ser Thr Asp Tyr Tyr Arg Val Gly Gly Arg Thr Met Leu Pro Ile Arg 
                645                 650                 655     


Trp Met Pro Pro Glu Ser Ile Leu Tyr Arg Lys Phe Thr Thr Glu Ser 
            660                 665                 670         


Asp Val Trp Ser Phe Gly Val Val Leu Trp Glu Ile Phe Thr Tyr Gly 
        675                 680                 685             


Lys Gln Pro Trp Tyr Gln Leu Ser Asn Thr Glu Ala Ile Asp Cys Ile 
    690                 695                 700                 


Thr Gln Gly Arg Glu Leu Glu Arg Pro Arg Ala Cys Pro Pro Glu Val 
705                 710                 715                 720 


Tyr Ala Ile Met Arg Gly Cys Trp Gln Arg Glu Pro Gln Gln Arg His 
                725                 730                 735     


Ser Ile Lys Asp Val His Ala Arg Leu Gln Ala Leu Ala Gln Ala Pro 
            740                 745                 750         


Pro Val Tyr Leu Asp Val Leu Gly 
        755                 760 


<210>  634
<211>  388
<212>  PRT
<213>  Homo sapiens

<400>  634

Met Lys Glu Ala Ala Leu Ile Cys Leu Ala Pro Ser Val Pro Pro Ile 
1               5                   10                  15      


Leu Thr Val Lys Ser Trp Asp Thr Met Gln Leu Arg Ala Ala Arg Ser 
            20                  25                  30          


Arg Cys Thr Asn Leu Leu Ala Ala Ser Tyr Ile Glu Asn Gln Gln His 
        35                  40                  45              


Leu Gln His Leu Glu Leu Arg Asp Leu Arg Gly Leu Gly Glu Leu Arg 
    50                  55                  60                  


Asn Leu Thr Ile Val Lys Ser Gly Leu Arg Phe Val Ala Pro Asp Ala 
65                  70                  75                  80  


Phe His Phe Thr Pro Arg Leu Ser Arg Leu Asn Leu Ser Phe Asn Ala 
                85                  90                  95      


Leu Glu Ser Leu Ser Trp Lys Thr Val Gln Gly Leu Ser Leu Gln Glu 
            100                 105                 110         


Leu Val Leu Ser Gly Asn Pro Leu His Cys Ser Cys Ala Leu Arg Trp 
        115                 120                 125             


Leu Gln Arg Trp Glu Glu Glu Gly Leu Gly Gly Val Pro Glu Gln Lys 
    130                 135                 140                 


Leu Gln Cys His Gly Gln Gly Pro Leu Ala His Met Pro Asn Ala Ser 
145                 150                 155                 160 


Cys Gly Val Pro Thr Leu Lys Val Gln Val Pro Asn Ala Ser Val Asp 
                165                 170                 175     


Val Gly Asp Asp Val Leu Leu Arg Cys Gln Val Glu Gly Arg Gly Leu 
            180                 185                 190         


Glu Gln Ala Gly Trp Ile Leu Thr Glu Leu Glu Gln Ser Ala Thr Val 
        195                 200                 205             


Met Ser Arg Pro Val Cys Ser Cys Thr Arg Arg Trp Arg Cys Thr Thr 
    210                 215                 220                 


Gly Ala Ser Pro Ser Leu Trp Met Gly Ser Arg His Arg Leu Cys Ala 
225                 230                 235                 240 


Gly Ser Ser Met Ala Pro Cys Ser Met Arg Pro Ala Ser Ser Ser Leu 
                245                 250                 255     


Ser Ser Trp Ser Arg Gln Pro Met Arg Pro Cys Gly Thr Gly Val Cys 
            260                 265                 270         


Ala Ser Thr Ser Pro Pro Thr Ser Thr Thr Ala Thr Thr Arg Cys Trp 
        275                 280                 285             


Leu Pro Thr Pro Ser Ala Arg Pro Pro Pro Pro Ser Trp Leu Pro Ser 
    290                 295                 300                 


Trp Thr Thr Leu Ser Ser Ser Thr Pro Arg Thr Pro Ser Leu Thr Leu 
305                 310                 315                 320 


Thr Ala His Leu Glu Thr Arg Trp Arg Arg Arg Thr Lys His Leu Leu 
                325                 330                 335     


Gly Ser Arg Trp Leu Trp Ala Trp Pro Ser Leu Pro Ala Ser Ser Phe 
            340                 345                 350         


Leu Arg Cys Ser Leu Cys Ser Thr Asn Val Asp Gly Glu Thr Ser Leu 
        355                 360                 365             


Gly Ser Thr Ala Arg Leu Cys Trp Leu Gln Arg Met Gly Trp Pro Cys 
    370                 375                 380                 


Pro Cys Ile Ser 
385             


<210>  635
<211>  796
<212>  PRT
<213>  Homo sapiens

<400>  635

Met Leu Arg Gly Gly Arg Arg Gly Gln Leu Gly Trp His Ser Trp Ala 
1               5                   10                  15      


Ala Gly Pro Gly Ser Leu Leu Ala Trp Leu Ile Leu Ala Ser Ala Gly 
            20                  25                  30          


Ala Ala Pro Cys Pro Asp Ala Cys Cys Pro His Gly Ser Ser Gly Leu 
        35                  40                  45              


Arg Cys Thr Arg Asp Gly Ala Leu Asp Ser Leu His His Leu Pro Gly 
    50                  55                  60                  


Ala Glu Asn Leu Thr Glu Leu Tyr Ile Glu Asn Gln Gln His Leu Gln 
65                  70                  75                  80  


His Leu Glu Leu Arg Asp Leu Arg Gly Leu Gly Glu Leu Arg Asn Leu 
                85                  90                  95      


Thr Ile Val Lys Ser Gly Leu Arg Phe Val Ala Pro Asp Ala Phe His 
            100                 105                 110         


Phe Thr Pro Arg Leu Ser Arg Leu Asn Leu Ser Phe Asn Ala Leu Glu 
        115                 120                 125             


Ser Leu Ser Trp Lys Thr Val Gln Gly Leu Ser Leu Gln Glu Leu Val 
    130                 135                 140                 


Leu Ser Gly Asn Pro Leu His Cys Ser Cys Ala Leu Arg Trp Leu Gln 
145                 150                 155                 160 


Arg Trp Glu Glu Glu Gly Leu Gly Gly Val Pro Glu Gln Lys Leu Gln 
                165                 170                 175     


Cys His Gly Gln Gly Pro Leu Ala His Met Pro Asn Ala Ser Cys Gly 
            180                 185                 190         


Val Pro Thr Leu Lys Val Gln Val Pro Asn Ala Ser Val Asp Val Gly 
        195                 200                 205             


Asp Asp Val Leu Leu Arg Cys Gln Val Glu Gly Arg Gly Leu Glu Gln 
    210                 215                 220                 


Ala Gly Trp Ile Leu Thr Glu Leu Glu Gln Ser Ala Thr Val Met Lys 
225                 230                 235                 240 


Ser Gly Gly Leu Pro Ser Leu Gly Leu Thr Leu Ala Asn Val Thr Ser 
                245                 250                 255     


Asp Leu Asn Arg Lys Asn Val Thr Cys Trp Ala Glu Asn Asp Val Gly 
            260                 265                 270         


Arg Ala Glu Val Ser Val Gln Val Asn Val Ser Phe Pro Ala Ser Val 
        275                 280                 285             


Gln Leu His Thr Ala Val Glu Met His His Trp Cys Ile Pro Phe Ser 
    290                 295                 300                 


Val Asp Gly Gln Pro Ala Pro Ser Leu Arg Trp Leu Phe Asn Gly Ser 
305                 310                 315                 320 


Val Leu Asn Glu Thr Ser Phe Ile Phe Thr Glu Phe Leu Glu Pro Ala 
                325                 330                 335     


Ala Asn Glu Thr Val Arg His Gly Cys Leu Arg Leu Asn Gln Pro Thr 
            340                 345                 350         


His Val Asn Asn Gly Asn Tyr Thr Leu Leu Ala Ala Asn Pro Phe Gly 
        355                 360                 365             


Gln Ala Ser Ala Ser Ile Met Ala Ala Phe Met Asp Asn Pro Phe Glu 
    370                 375                 380                 


Phe Asn Pro Glu Asp Pro Ile Pro Val Ser Phe Ser Pro Val Asp Thr 
385                 390                 395                 400 


Asn Ser Thr Ser Gly Asp Pro Val Glu Lys Lys Asp Glu Thr Pro Phe 
                405                 410                 415     


Gly Val Ser Val Ala Val Gly Leu Ala Val Phe Ala Cys Leu Phe Leu 
            420                 425                 430         


Ser Thr Leu Leu Leu Val Leu Asn Lys Cys Gly Arg Arg Asn Lys Phe 
        435                 440                 445             


Gly Ile Asn Arg Pro Ala Val Leu Ala Pro Glu Asp Gly Leu Ala Met 
    450                 455                 460                 


Ser Leu His Phe Met Thr Leu Gly Gly Ser Ser Leu Ser Pro Thr Glu 
465                 470                 475                 480 


Gly Lys Gly Ser Gly Leu Gln Gly His Ile Ile Glu Asn Pro Gln Tyr 
                485                 490                 495     


Phe Ser Asp Ala Cys Val His His Ile Lys Arg Arg Asp Ile Val Leu 
            500                 505                 510         


Lys Trp Glu Leu Gly Glu Gly Ala Phe Gly Lys Val Phe Leu Ala Glu 
        515                 520                 525             


Cys His Asn Leu Leu Pro Glu Gln Asp Lys Met Leu Val Ala Val Lys 
    530                 535                 540                 


Ala Leu Lys Glu Ala Ser Glu Ser Ala Arg Gln Asp Phe Gln Arg Glu 
545                 550                 555                 560 


Ala Glu Leu Leu Thr Met Leu Gln His Gln His Ile Val Arg Phe Phe 
                565                 570                 575     


Gly Val Cys Thr Glu Gly Arg Pro Leu Leu Met Val Phe Glu Tyr Met 
            580                 585                 590         


Arg His Gly Asp Leu Asn Arg Phe Leu Arg Ser His Gly Pro Asp Ala 
        595                 600                 605             


Lys Leu Leu Ala Gly Gly Glu Asp Val Ala Pro Gly Pro Leu Gly Leu 
    610                 615                 620                 


Gly Gln Leu Leu Ala Val Ala Ser Gln Val Ala Ala Gly Met Val Tyr 
625                 630                 635                 640 


Leu Ala Gly Leu His Phe Val His Arg Asp Leu Ala Thr Arg Asn Cys 
                645                 650                 655     


Leu Val Gly Gln Gly Leu Val Val Lys Ile Gly Asp Phe Gly Met Ser 
            660                 665                 670         


Arg Asp Ile Tyr Ser Thr Asp Tyr Tyr Arg Val Gly Gly Arg Thr Met 
        675                 680                 685             


Leu Pro Ile Arg Trp Met Pro Pro Glu Ser Ile Leu Tyr Arg Lys Phe 
    690                 695                 700                 


Thr Thr Glu Ser Asp Val Trp Ser Phe Gly Val Val Leu Trp Glu Ile 
705                 710                 715                 720 


Phe Thr Tyr Gly Lys Gln Pro Trp Tyr Gln Leu Ser Asn Thr Glu Ala 
                725                 730                 735     


Ile Asp Cys Ile Thr Gln Gly Arg Glu Leu Glu Arg Pro Arg Ala Cys 
            740                 745                 750         


Pro Pro Glu Val Tyr Ala Ile Met Arg Gly Cys Trp Gln Arg Glu Pro 
        755                 760                 765             


Gln Gln Arg His Ser Ile Lys Asp Val His Ala Arg Leu Gln Ala Leu 
    770                 775                 780                 


Ala Gln Ala Pro Pro Val Tyr Leu Asp Val Leu Gly 
785                 790                 795     


<210>  636
<211>  131
<212>  PRT
<213>  Homo sapiens

<400>  636

Met Ser Lys Arg Tyr Leu Gln Lys Ala Thr Lys Gly Lys Leu Leu Ile 
1               5                   10                  15      


Ile Ile Phe Ile Val Thr Leu Trp Gly Lys Val Val Ser Ser Ala Asn 
            20                  25                  30          


His His Lys Ala His His Val Lys Thr Gly Thr Cys Glu Val Val Ala 
        35                  40                  45              


Leu His Arg Cys Cys Asn Lys Asn Lys Ile Glu Glu Arg Ser Gln Thr 
    50                  55                  60                  


Val Lys Cys Ser Cys Phe Pro Gly Gln Val Ala Gly Thr Thr Arg Ala 
65                  70                  75                  80  


Ala Pro Ser Cys Val Asp Ala Ser Ile Val Glu Gln Lys Trp Trp Cys 
                85                  90                  95      


His Met Gln Pro Cys Leu Glu Gly Glu Glu Cys Lys Val Leu Pro Asp 
            100                 105                 110         


Arg Lys Gly Trp Ser Cys Ser Ser Gly Asn Lys Val Lys Thr Thr Arg 
        115                 120                 125             


Val Thr His 
    130     


<210>  637
<211>  87
<212>  PRT
<213>  Homo sapiens

<400>  637

Met Met Ser Lys Arg Tyr Leu Gln Lys Ala Thr Lys Gly Lys Leu Leu 
1               5                   10                  15      


Ile Ile Ile Phe Ile Val Thr Leu Trp Gly Lys Val Val Ser Ser Ala 
            20                  25                  30          


Asn His His Lys Ala His His Val Lys Thr Gly Thr Cys Glu Val Val 
        35                  40                  45              


Ala Leu His Arg Cys Cys Asn Lys Asn Lys Ile Glu Glu Arg Ser Gln 
    50                  55                  60                  


Thr Val Lys Cys Ser Cys Phe Pro Gly Gln Val Ala Gly Thr Thr Arg 
65                  70                  75                  80  


Ala Ala Pro Ser Cys Val Asp 
                85          


<210>  638
<211>  131
<212>  PRT
<213>  Homo sapiens

<400>  638

Met Ser Lys Arg Tyr Leu Gln Lys Ala Thr Lys Gly Lys Leu Leu Ile 
1               5                   10                  15      


Ile Ile Phe Ile Val Thr Leu Trp Gly Lys Val Val Ser Ser Ala Asn 
            20                  25                  30          


His His Lys Ala His His Val Lys Thr Gly Thr Cys Glu Val Val Ala 
        35                  40                  45              


Leu His Arg Cys Cys Asn Lys Asn Lys Ile Glu Glu Arg Ser Gln Thr 
    50                  55                  60                  


Val Lys Cys Ser Cys Phe Pro Gly Gln Val Ala Gly Thr Thr Arg Ala 
65                  70                  75                  80  


Ala Pro Ser Cys Val Asp Ala Ser Ile Val Glu Gln Lys Trp Trp Cys 
                85                  90                  95      


His Met Gln Pro Cys Leu Glu Gly Glu Glu Cys Lys Val Leu Pro Asp 
            100                 105                 110         


Arg Lys Gly Trp Ser Cys Ser Ser Gly Asn Lys Val Lys Thr Thr Arg 
        115                 120                 125             


Ala Asn Val 
    130     


<210>  639
<211>  101
<212>  PRT
<213>  Homo sapiens

<400>  639

Met Val Thr Pro Ile Thr Arg Met Ser Lys Arg Tyr Leu Gln Lys Ala 
1               5                   10                  15      


Thr Lys Gly Lys Leu Leu Ile Ile Ile Phe Ile Val Thr Leu Trp Gly 
            20                  25                  30          


Lys Val Val Ser Ser Ala Asn His His Lys Ala His His Val Lys Thr 
        35                  40                  45              


Gly Thr Cys Glu Val Val Ala Leu His Arg Cys Cys Asn Lys Asn Lys 
    50                  55                  60                  


Ile Glu Glu Arg Ser Gln Thr Val Lys Cys Ser Cys Phe Pro Gly Gln 
65                  70                  75                  80  


Val Ala Gly Thr Thr Arg Ala Ala Pro Ser Cys Val Asp Ala Ser Ile 
                85                  90                  95      


Val Glu Gln Lys Trp 
            100     


<210>  640
<211>  34
<212>  PRT
<213>  Homo sapiens

<400>  640

Met Gln Pro Cys Leu Glu Gly Glu Glu Cys Lys Val Leu Pro Asp Arg 
1               5                   10                  15      


Lys Gly Trp Ser Cys Ser Ser Gly Asn Lys Val Lys Thr Thr Arg Val 
            20                  25                  30          


Thr His 
        


<210>  641
<211>  49
<212>  PRT
<213>  Homo sapiens

<400>  641

Met Ser Lys Arg Tyr Leu Gln Lys Ala Thr Lys Gly Lys Leu Leu Ile 
1               5                   10                  15      


Ile Ile Phe Ile Val Thr Leu Trp Gly Lys Val Val Ser Ser Ala Asn 
            20                  25                  30          


His His Lys Gly Asn Pro Leu Thr Gln Glu Lys Ser Ser Asp Pro Gln 
        35                  40                  45              


Gly 
    


<210>  642
<211>  131
<212>  PRT
<213>  Homo sapiens

<400>  642

Met Ser Lys Arg Tyr Leu Gln Lys Ala Thr Lys Gly Lys Leu Leu Ile 
1               5                   10                  15      


Ile Ile Phe Ile Val Thr Leu Trp Gly Lys Val Val Ser Ser Ala Asn 
            20                  25                  30          


His His Lys Ala His His Val Lys Thr Gly Thr Cys Glu Val Val Ala 
        35                  40                  45              


Leu His Arg Cys Cys Asn Lys Asn Lys Ile Glu Glu Arg Ser Gln Thr 
    50                  55                  60                  


Val Lys Cys Ser Cys Phe Pro Gly Gln Val Ala Gly Thr Thr Arg Ala 
65                  70                  75                  80  


Ala Pro Ser Cys Val Asp Ala Ser Ile Val Glu Gln Lys Trp Trp Cys 
                85                  90                  95      


His Met Gln Pro Cys Leu Glu Gly Glu Glu Cys Lys Val Leu Pro Asp 
            100                 105                 110         


Arg Lys Gly Trp Ser Cys Ser Ser Gly Asn Lys Val Lys Thr Thr Arg 
        115                 120                 125             


Val Thr His 
    130     


<210>  643
<211>  110
<212>  PRT
<213>  Homo sapiens

<400>  643

Met Met Ser Lys Arg Tyr Leu Gln Lys Ala Thr Lys Gly Lys Leu Leu 
1               5                   10                  15      


Ile Ile Ile Phe Ile Val Thr Leu Trp Gly Lys Val Val Ser Ser Ala 
            20                  25                  30          


Asn His His Lys Ala His His Val Lys Thr Gly Thr Cys Glu Val Val 
        35                  40                  45              


Ala Leu His Arg Cys Cys Asn Lys Asn Lys Ile Glu Glu Arg Ser Gln 
    50                  55                  60                  


Thr Val Lys Cys Ser Cys Phe Pro Gly Gln Val Ala Gly Thr Thr Arg 
65                  70                  75                  80  


Ala Ala Pro Ser Cys Val Asp Ala Ser Ile Val Glu Gln Lys Trp Trp 
                85                  90                  95      


Cys His Met Gln Pro Cys Leu Glu Gly Glu Glu Cys Lys Val 
            100                 105                 110 


<210>  644
<211>  2229
<212>  PRT
<213>  Homo sapiens

<400>  644

Met Phe Pro Gly Cys Pro Arg Leu Trp Val Leu Val Val Leu Gly Thr 
1               5                   10                  15      


Ser Trp Val Gly Trp Gly Ser Gln Gly Thr Glu Ala Ala Gln Leu Arg 
            20                  25                  30          


Gln Phe Tyr Val Ala Ala Gln Gly Ile Ser Trp Ser Tyr Arg Pro Glu 
        35                  40                  45              


Pro Thr Asn Ser Ser Leu Asn Leu Ser Val Thr Ser Phe Lys Lys Ile 
    50                  55                  60                  


Val Tyr Arg Glu Tyr Glu Pro Tyr Phe Lys Lys Glu Lys Pro Gln Ser 
65                  70                  75                  80  


Thr Ile Ser Gly Leu Leu Gly Pro Thr Leu Tyr Ala Glu Val Gly Asp 
                85                  90                  95      


Ile Ile Lys Val His Phe Lys Asn Lys Ala Asp Lys Pro Leu Ser Ile 
            100                 105                 110         


His Pro Gln Gly Ile Arg Tyr Ser Lys Leu Ser Glu Gly Ala Ser Tyr 
        115                 120                 125             


Leu Asp His Thr Phe Pro Ala Glu Lys Met Asp Asp Ala Val Ala Pro 
    130                 135                 140                 


Gly Arg Glu Tyr Thr Tyr Glu Trp Ser Ile Ser Glu Asp Ser Gly Pro 
145                 150                 155                 160 


Thr His Asp Asp Pro Pro Cys Leu Thr His Ile Tyr Tyr Ser His Glu 
                165                 170                 175     


Asn Leu Ile Glu Asp Phe Asn Ser Gly Leu Ile Gly Pro Leu Leu Ile 
            180                 185                 190         


Cys Lys Lys Gly Thr Leu Thr Glu Gly Gly Thr Gln Lys Thr Phe Asp 
        195                 200                 205             


Lys Gln Ile Val Leu Leu Phe Ala Val Phe Asp Glu Ser Lys Ser Trp 
    210                 215                 220                 


Ser Gln Ser Ser Ser Leu Met Tyr Thr Val Asn Gly Tyr Val Asn Gly 
225                 230                 235                 240 


Thr Met Pro Asp Ile Thr Val Cys Ala His Asp His Ile Ser Trp His 
                245                 250                 255     


Leu Leu Gly Met Ser Ser Gly Pro Glu Leu Phe Ser Ile His Phe Asn 
            260                 265                 270         


Gly Gln Val Leu Glu Gln Asn His His Lys Val Ser Ala Ile Thr Leu 
        275                 280                 285             


Val Ser Ala Thr Ser Thr Thr Ala Asn Met Thr Val Gly Pro Glu Gly 
    290                 295                 300                 


Lys Trp Ile Ile Ser Ser Leu Thr Pro Lys His Leu Gln Ala Gly Met 
305                 310                 315                 320 


Gln Ala Tyr Ile Asp Ile Lys Asn Cys Pro Lys Lys Thr Arg Asn Leu 
                325                 330                 335     


Lys Lys Ile Thr Arg Glu Gln Arg Arg His Met Lys Arg Trp Glu Tyr 
            340                 345                 350         


Phe Ile Ala Ala Glu Glu Val Ile Trp Asp Tyr Ala Pro Val Ile Pro 
        355                 360                 365             


Ala Asn Met Asp Lys Lys Tyr Arg Ser Gln His Leu Asp Asn Phe Ser 
    370                 375                 380                 


Asn Gln Ile Gly Lys His Tyr Lys Lys Val Met Tyr Thr Gln Tyr Glu 
385                 390                 395                 400 


Asp Glu Ser Phe Thr Lys His Thr Val Asn Pro Asn Met Lys Glu Asp 
                405                 410                 415     


Gly Ile Leu Gly Pro Ile Ile Arg Ala Gln Val Arg Asp Thr Leu Lys 
            420                 425                 430         


Ile Val Phe Lys Asn Met Ala Ser Arg Pro Tyr Ser Ile Tyr Pro His 
        435                 440                 445             


Gly Val Thr Phe Ser Pro Tyr Glu Asp Glu Val Asn Ser Ser Phe Thr 
    450                 455                 460                 


Ser Gly Arg Asn Asn Thr Met Ile Arg Ala Val Gln Pro Gly Glu Thr 
465                 470                 475                 480 


Tyr Thr Tyr Lys Trp Asn Ile Leu Glu Phe Asp Glu Pro Thr Glu Asn 
                485                 490                 495     


Asp Ala Gln Cys Leu Thr Arg Pro Tyr Tyr Ser Asp Val Asp Ile Met 
            500                 505                 510         


Arg Asp Ile Ala Ser Gly Leu Ile Gly Leu Leu Leu Ile Cys Lys Ser 
        515                 520                 525             


Arg Ser Leu Asp Arg Arg Gly Ile Gln Arg Ala Ala Asp Ile Glu Gln 
    530                 535                 540                 


Gln Ala Val Phe Ala Val Phe Asp Glu Asn Lys Ser Trp Tyr Leu Glu 
545                 550                 555                 560 


Asp Asn Ile Asn Lys Phe Cys Glu Asn Pro Asp Glu Val Lys Arg Asp 
                565                 570                 575     


Asp Pro Lys Phe Tyr Glu Ser Asn Ile Met Ser Asn Phe Thr Leu Ser 
            580                 585                 590         


Ala Ile Asn Gly Tyr Val Pro Glu Ser Ile Thr Thr Leu Gly Phe Cys 
        595                 600                 605             


Phe Asp Asp Thr Val Gln Trp His Phe Cys Ser Val Gly Thr Gln Asn 
    610                 615                 620                 


Glu Ile Leu Thr Ile His Phe Thr Gly His Ser Phe Ile Tyr Gly Lys 
625                 630                 635                 640 


Arg His Glu Asp Thr Leu Thr Leu Phe Pro Met Arg Gly Glu Ser Val 
                645                 650                 655     


Thr Val Thr Met Asp Asn Val Gly Thr Trp Met Leu Thr Ser Met Asn 
            660                 665                 670         


Ser Ser Pro Arg Ser Lys Lys Leu Arg Leu Lys Phe Arg Asp Val Lys 
        675                 680                 685             


Cys Ile Pro Asp Asp Asp Glu Asp Ser Tyr Glu Ile Phe Glu Pro Pro 
    690                 695                 700                 


Glu Ser Thr Val Met Ala Thr Arg Lys Met His Asp Arg Leu Glu Pro 
705                 710                 715                 720 


Glu Asp Glu Glu Ser Asp Ala Asp Tyr Asp Tyr Gln Asn Arg Leu Ala 
                725                 730                 735     


Ala Ala Leu Gly Ile Arg Ser Phe Arg Asn Ser Ser Leu Asn Gln Glu 
            740                 745                 750         


Glu Glu Glu Phe Asn Leu Thr Ala Leu Ala Leu Glu Asn Gly Thr Glu 
        755                 760                 765             


Phe Val Ser Ser Asn Thr Asp Ile Ile Val Gly Ser Asn Tyr Ser Ser 
    770                 775                 780                 


Pro Ser Asn Ile Ser Lys Phe Thr Val Asn Asn Leu Ala Glu Pro Gln 
785                 790                 795                 800 


Lys Ala Pro Ser His Gln Gln Ala Thr Thr Ala Gly Ser Pro Leu Arg 
                805                 810                 815     


His Leu Ile Gly Lys Asn Ser Val Leu Asn Ser Ser Thr Ala Glu His 
            820                 825                 830         


Ser Ser Pro Tyr Ser Glu Asp Pro Ile Glu Asp Pro Leu Gln Pro Asp 
        835                 840                 845             


Val Thr Gly Ile Arg Leu Leu Ser Leu Gly Ala Gly Glu Phe Lys Ser 
    850                 855                 860                 


Gln Glu His Ala Lys His Lys Gly Pro Lys Val Glu Arg Asp Gln Ala 
865                 870                 875                 880 


Ala Lys His Arg Phe Ser Trp Met Lys Leu Leu Ala His Lys Val Gly 
                885                 890                 895     


Arg His Leu Ser Gln Asp Thr Gly Ser Pro Ser Gly Met Arg Pro Trp 
            900                 905                 910         


Glu Asp Leu Pro Ser Gln Asp Thr Gly Ser Pro Ser Arg Met Arg Pro 
        915                 920                 925             


Trp Lys Asp Pro Pro Ser Asp Leu Leu Leu Leu Lys Gln Ser Asn Ser 
    930                 935                 940                 


Ser Lys Ile Leu Val Gly Arg Trp His Leu Ala Ser Glu Lys Gly Ser 
945                 950                 955                 960 


Tyr Glu Ile Ile Gln Asp Thr Asp Glu Asp Thr Ala Val Asn Asn Trp 
                965                 970                 975     


Leu Ile Ser Pro Gln Asn Ala Ser Arg Ala Trp Gly Glu Ser Thr Pro 
            980                 985                 990         


Leu Ala Asn Lys Pro Gly Lys Gln  Ser Gly His Pro Lys  Phe Pro Arg 
        995                 1000                 1005             


Val Arg  His Lys Ser Leu Gln  Val Arg Gln Asp Gly  Gly Lys Ser 
    1010                 1015                 1020             


Arg Leu  Lys Lys Ser Gln Phe  Leu Ile Lys Thr Arg  Lys Lys Lys 
    1025                 1030                 1035             


Lys Glu  Lys His Thr His His  Ala Pro Leu Ser Pro  Arg Thr Phe 
    1040                 1045                 1050             


His Pro  Leu Arg Ser Glu Ala  Tyr Asn Thr Phe Ser  Glu Arg Arg 
    1055                 1060                 1065             


Leu Lys  His Ser Leu Val Leu  His Lys Ser Asn Glu  Thr Ser Leu 
    1070                 1075                 1080             


Pro Thr  Asp Leu Asn Gln Thr  Leu Pro Ser Met Asp  Phe Gly Trp 
    1085                 1090                 1095             


Ile Ala  Ser Leu Pro Asp His  Asn Gln Asn Ser Ser  Asn Asp Thr 
    1100                 1105                 1110             


Gly Gln  Ala Ser Cys Pro Pro  Gly Leu Tyr Gln Thr  Val Pro Pro 
    1115                 1120                 1125             


Glu Glu  His Tyr Gln Thr Phe  Pro Ile Gln Asp Pro  Asp Gln Met 
    1130                 1135                 1140             


His Ser  Thr Ser Asp Pro Ser  His Arg Ser Ser Ser  Pro Glu Leu 
    1145                 1150                 1155             


Ser Glu  Met Leu Glu Tyr Asp  Arg Ser His Lys Ser  Phe Pro Thr 
    1160                 1165                 1170             


Asp Ile  Ser Gln Met Ser Pro  Ser Ser Glu His Glu  Val Trp Gln 
    1175                 1180                 1185             


Thr Val  Ile Ser Pro Asp Leu  Ser Gln Val Thr Leu  Ser Pro Glu 
    1190                 1195                 1200             


Leu Ser  Gln Thr Asn Leu Ser  Pro Asp Leu Ser His  Thr Thr Leu 
    1205                 1210                 1215             


Ser Pro  Glu Leu Ile Gln Arg  Asn Leu Ser Pro Ala  Leu Gly Gln 
    1220                 1225                 1230             


Met Pro  Ile Ser Pro Asp Leu  Ser His Thr Thr Leu  Ser Pro Asp 
    1235                 1240                 1245             


Leu Ser  His Thr Thr Leu Ser  Leu Asp Leu Ser Gln  Thr Asn Leu 
    1250                 1255                 1260             


Ser Pro  Glu Leu Ser Gln Thr  Asn Leu Ser Pro Ala  Leu Gly Gln 
    1265                 1270                 1275             


Met Pro  Leu Ser Pro Asp Leu  Ser His Thr Thr Leu  Ser Leu Asp 
    1280                 1285                 1290             


Phe Ser  Gln Thr Asn Leu Ser  Pro Glu Leu Ser His  Met Thr Leu 
    1295                 1300                 1305             


Ser Pro  Glu Leu Ser Gln Thr  Asn Leu Ser Pro Ala  Leu Gly Gln 
    1310                 1315                 1320             


Met Pro  Ile Ser Pro Asp Leu  Ser His Thr Thr Leu  Ser Leu Asp 
    1325                 1330                 1335             


Phe Ser  Gln Thr Asn Leu Ser  Pro Glu Leu Ser Gln  Thr Asn Leu 
    1340                 1345                 1350             


Ser Pro  Ala Leu Gly Gln Met  Pro Leu Ser Pro Asp  Pro Ser His 
    1355                 1360                 1365             


Thr Thr  Leu Ser Leu Asp Leu  Ser Gln Thr Asn Leu  Ser Pro Glu 
    1370                 1375                 1380             


Leu Ser  Gln Thr Asn Leu Ser  Pro Asp Leu Ser Glu  Met Pro Leu 
    1385                 1390                 1395             


Phe Ala  Asp Leu Ser Gln Ile  Pro Leu Thr Pro Asp  Leu Asp Gln 
    1400                 1405                 1410             


Met Thr  Leu Ser Pro Asp Leu  Gly Glu Thr Asp Leu  Ser Pro Asn 
    1415                 1420                 1425             


Phe Gly  Gln Met Ser Leu Ser  Pro Asp Leu Ser Gln  Val Thr Leu 
    1430                 1435                 1440             


Ser Pro  Asp Ile Ser Asp Thr  Thr Leu Leu Pro Asp  Leu Ser Gln 
    1445                 1450                 1455             


Ile Ser  Pro Pro Pro Asp Leu  Asp Gln Ile Phe Tyr  Pro Ser Glu 
    1460                 1465                 1470             


Ser Ser  Gln Ser Leu Leu Leu  Gln Glu Phe Asn Glu  Ser Phe Pro 
    1475                 1480                 1485             


Tyr Pro  Asp Leu Gly Gln Met  Pro Ser Pro Ser Ser  Pro Thr Leu 
    1490                 1495                 1500             


Asn Asp  Thr Phe Leu Ser Lys  Glu Phe Asn Pro Leu  Val Ile Val 
    1505                 1510                 1515             


Gly Leu  Ser Lys Asp Gly Thr  Asp Tyr Ile Glu Ile  Ile Pro Lys 
    1520                 1525                 1530             


Glu Glu  Val Gln Ser Ser Glu  Asp Asp Tyr Ala Glu  Ile Asp Tyr 
    1535                 1540                 1545             


Val Pro  Tyr Asp Asp Pro Tyr  Lys Thr Asp Val Arg  Thr Asn Ile 
    1550                 1555                 1560             


Asn Ser  Ser Arg Asp Pro Asp  Asn Ile Ala Ala Trp  Tyr Leu Arg 
    1565                 1570                 1575             


Ser Asn  Asn Gly Asn Arg Arg  Asn Tyr Tyr Ile Ala  Ala Glu Glu 
    1580                 1585                 1590             


Ile Ser  Trp Asp Tyr Ser Glu  Phe Val Gln Arg Glu  Thr Asp Ile 
    1595                 1600                 1605             


Glu Asp  Ser Asp Asp Ile Pro  Glu Asp Thr Thr Tyr  Lys Lys Val 
    1610                 1615                 1620             


Val Phe  Arg Lys Tyr Leu Asp  Ser Thr Phe Thr Lys  Arg Asp Pro 
    1625                 1630                 1635             


Arg Gly  Glu Tyr Glu Glu His  Leu Gly Ile Leu Gly  Pro Ile Ile 
    1640                 1645                 1650             


Arg Ala  Glu Val Asp Asp Val  Ile Gln Val Arg Phe  Lys Asn Leu 
    1655                 1660                 1665             


Ala Ser  Arg Pro Tyr Ser Leu  His Ala His Gly Leu  Ser Tyr Glu 
    1670                 1675                 1680             


Lys Ser  Ser Glu Gly Lys Thr  Tyr Glu Asp Asp Ser  Pro Glu Trp 
    1685                 1690                 1695             


Phe Lys  Glu Asp Asn Ala Val  Gln Pro Asn Ser Ser  Tyr Thr Tyr 
    1700                 1705                 1710             


Val Trp  His Ala Thr Glu Arg  Ser Gly Pro Glu Ser  Pro Gly Ser 
    1715                 1720                 1725             


Ala Cys  Arg Ala Trp Ala Tyr  Tyr Ser Ala Val Asn  Pro Glu Lys 
    1730                 1735                 1740             


Asp Ile  His Ser Gly Leu Ile  Gly Pro Leu Leu Ile  Cys Gln Lys 
    1745                 1750                 1755             


Gly Ile  Leu His Lys Asp Ser  Asn Met Pro Met Asp  Met Arg Glu 
    1760                 1765                 1770             


Phe Val  Leu Leu Phe Met Thr  Phe Asp Glu Lys Lys  Ser Trp Tyr 
    1775                 1780                 1785             


Tyr Glu  Lys Lys Ser Arg Ser  Ser Trp Arg Leu Thr  Ser Ser Glu 
    1790                 1795                 1800             


Met Lys  Lys Ser His Glu Phe  His Ala Ile Asn Gly  Met Ile Tyr 
    1805                 1810                 1815             


Ser Leu  Pro Gly Leu Lys Met  Tyr Glu Gln Glu Trp  Val Arg Leu 
    1820                 1825                 1830             


His Leu  Leu Asn Ile Gly Gly  Ser Gln Asp Ile His  Val Val His 
    1835                 1840                 1845             


Phe His  Gly Gln Thr Leu Leu  Glu Asn Gly Asn Lys  Gln His Gln 
    1850                 1855                 1860             


Leu Gly  Val Trp Pro Leu Leu  Pro Gly Ser Phe Lys  Thr Leu Glu 
    1865                 1870                 1875             


Met Lys  Ala Ser Lys Pro Gly  Trp Trp Leu Leu Asn  Thr Glu Val 
    1880                 1885                 1890             


Gly Glu  Asn Gln Arg Ala Gly  Met Gln Thr Pro Phe  Leu Ile Met 
    1895                 1900                 1905             


Asp Arg  Asp Cys Arg Met Pro  Met Gly Leu Ser Thr  Gly Ile Ile 
    1910                 1915                 1920             


Ser Asp  Ser Gln Ile Lys Ala  Ser Glu Phe Leu Gly  Tyr Trp Glu 
    1925                 1930                 1935             


Pro Arg  Leu Ala Arg Leu Asn  Asn Gly Gly Ser Tyr  Asn Ala Trp 
    1940                 1945                 1950             


Ser Val  Glu Lys Leu Ala Ala  Glu Phe Ala Ser Lys  Pro Trp Ile 
    1955                 1960                 1965             


Gln Val  Asp Met Gln Lys Glu  Val Ile Ile Thr Gly  Ile Gln Thr 
    1970                 1975                 1980             


Gln Gly  Ala Lys His Tyr Leu  Lys Ser Cys Tyr Thr  Thr Glu Phe 
    1985                 1990                 1995             


Tyr Val  Ala Tyr Ser Ser Asn  Gln Ile Asn Trp Gln  Ile Phe Lys 
    2000                 2005                 2010             


Gly Asn  Ser Thr Arg Asn Val  Met Tyr Phe Asn Gly  Asn Ser Asp 
    2015                 2020                 2025             


Ala Ser  Thr Ile Lys Glu Asn  Gln Phe Asp Pro Pro  Ile Val Ala 
    2030                 2035                 2040             


Arg Tyr  Ile Arg Ile Ser Pro  Thr Arg Ala Tyr Asn  Arg Pro Thr 
    2045                 2050                 2055             


Leu Arg  Leu Glu Leu Gln Gly  Cys Glu Val Asn Gly  Cys Ser Thr 
    2060                 2065                 2070             


Pro Leu  Gly Met Glu Asn Gly  Lys Ile Glu Asn Lys  Gln Ile Thr 
    2075                 2080                 2085             


Ala Ser  Ser Phe Lys Lys Ser  Trp Trp Gly Asp Tyr  Trp Glu Pro 
    2090                 2095                 2100             


Phe Arg  Ala Arg Leu Asn Ala  Gln Gly Arg Val Asn  Ala Trp Gln 
    2105                 2110                 2115             


Ala Lys  Ala Asn Asn Asn Lys  Gln Trp Leu Glu Ile  Asp Leu Leu 
    2120                 2125                 2130             


Lys Ile  Lys Lys Ile Thr Ala  Ile Ile Thr Gln Gly  Cys Lys Ser 
    2135                 2140                 2145             


Leu Ser  Ser Glu Met Tyr Val  Lys Ser Tyr Thr Ile  His Tyr Ser 
    2150                 2155                 2160             


Glu Gln  Gly Val Glu Trp Lys  Pro Tyr Arg Leu Lys  Ser Ser Met 
    2165                 2170                 2175             


Val Asp  Lys Ile Phe Glu Gly  Asn Thr Asn Thr Lys  Gly His Val 
    2180                 2185                 2190             


Lys Asn  Phe Phe Asn Pro Pro  Ile Ile Ser Arg Phe  Ile Arg Val 
    2195                 2200                 2205             


Ile Pro  Lys Thr Trp Asn Gln  Ser Ile Ala Leu Arg  Leu Glu Leu 
    2210                 2215                 2220             


Phe Gly  Cys Asp Ile Tyr 
    2225                 


<210>  645
<211>  2224
<212>  PRT
<213>  Homo sapiens

<400>  645

Met Phe Pro Gly Cys Pro Arg Leu Trp Val Leu Val Val Leu Gly Thr 
1               5                   10                  15      


Ser Trp Val Gly Trp Gly Ser Gln Gly Thr Glu Ala Ala Gln Leu Arg 
            20                  25                  30          


Gln Phe Tyr Val Ala Ala Gln Gly Ile Ser Trp Ser Tyr Arg Pro Glu 
        35                  40                  45              


Pro Thr Asn Ser Ser Leu Asn Leu Ser Val Thr Ser Phe Lys Lys Ile 
    50                  55                  60                  


Val Tyr Arg Glu Tyr Glu Pro Tyr Phe Lys Lys Glu Lys Pro Gln Ser 
65                  70                  75                  80  


Thr Ile Ser Gly Leu Leu Gly Pro Thr Leu Tyr Ala Glu Val Gly Asp 
                85                  90                  95      


Ile Ile Lys Val His Phe Lys Asn Lys Ala Asp Lys Pro Leu Ser Ile 
            100                 105                 110         


His Pro Gln Gly Ile Arg Tyr Ser Lys Leu Ser Glu Gly Ala Ser Tyr 
        115                 120                 125             


Leu Asp His Thr Phe Pro Ala Glu Lys Met Asp Asp Ala Val Ala Pro 
    130                 135                 140                 


Gly Arg Glu Tyr Thr Tyr Glu Trp Ser Ile Ser Glu Asp Ser Gly Pro 
145                 150                 155                 160 


Thr His Asp Asp Pro Pro Cys Leu Thr His Ile Tyr Tyr Ser His Glu 
                165                 170                 175     


Asn Leu Ile Glu Asp Phe Asn Ser Gly Leu Ile Gly Pro Leu Leu Ile 
            180                 185                 190         


Cys Lys Lys Gly Thr Leu Thr Glu Gly Gly Thr Gln Lys Thr Phe Asp 
        195                 200                 205             


Lys Gln Ile Val Leu Leu Phe Ala Val Phe Asp Glu Ser Lys Ser Trp 
    210                 215                 220                 


Ser Gln Ser Ser Ser Leu Met Tyr Thr Val Asn Gly Tyr Val Asn Gly 
225                 230                 235                 240 


Thr Met Pro Asp Ile Thr Val Cys Ala His Asp His Ile Ser Trp His 
                245                 250                 255     


Leu Leu Gly Met Ser Ser Gly Pro Glu Leu Phe Ser Ile His Phe Asn 
            260                 265                 270         


Gly Gln Val Leu Glu Gln Asn His His Lys Val Ser Ala Ile Thr Leu 
        275                 280                 285             


Val Ser Ala Thr Ser Thr Thr Ala Asn Met Thr Val Gly Pro Glu Gly 
    290                 295                 300                 


Lys Trp Ile Ile Ser Ser Leu Thr Pro Lys His Leu Gln Ala Gly Met 
305                 310                 315                 320 


Gln Ala Tyr Ile Asp Ile Lys Asn Cys Pro Lys Lys Thr Arg Asn Leu 
                325                 330                 335     


Lys Lys Ile Thr Arg Glu Gln Arg Arg His Met Lys Arg Trp Glu Tyr 
            340                 345                 350         


Phe Ile Ala Ala Glu Glu Val Ile Trp Asp Tyr Ala Pro Val Ile Pro 
        355                 360                 365             


Ala Asn Met Asp Lys Lys Tyr Arg Ser Gln His Leu Asp Asn Phe Ser 
    370                 375                 380                 


Asn Gln Ile Gly Lys His Tyr Lys Lys Val Met Tyr Thr Gln Tyr Glu 
385                 390                 395                 400 


Asp Glu Ser Phe Thr Lys His Thr Val Asn Pro Asn Met Lys Glu Asp 
                405                 410                 415     


Gly Ile Leu Gly Pro Ile Ile Arg Ala Gln Val Arg Asp Thr Leu Lys 
            420                 425                 430         


Ile Val Phe Lys Asn Met Ala Ser Arg Pro Tyr Ser Ile Tyr Pro His 
        435                 440                 445             


Gly Val Thr Phe Ser Pro Tyr Glu Asp Glu Val Asn Ser Ser Phe Thr 
    450                 455                 460                 


Ser Gly Arg Asn Asn Thr Met Ile Arg Ala Val Gln Pro Gly Glu Thr 
465                 470                 475                 480 


Tyr Thr Tyr Lys Trp Asn Ile Leu Glu Phe Asp Glu Pro Thr Glu Asn 
                485                 490                 495     


Asp Ala Gln Cys Leu Thr Arg Pro Tyr Tyr Ser Asp Val Asp Ile Met 
            500                 505                 510         


Arg Asp Ile Ala Ser Gly Leu Ile Gly Leu Leu Leu Ile Cys Lys Ser 
        515                 520                 525             


Arg Ser Leu Asp Arg Arg Gly Ile Gln Arg Ala Ala Asp Ile Glu Gln 
    530                 535                 540                 


Gln Ala Val Phe Ala Val Phe Asp Glu Asn Lys Ser Trp Tyr Leu Glu 
545                 550                 555                 560 


Asp Asn Ile Asn Lys Phe Cys Glu Asn Pro Asp Glu Val Lys Arg Asp 
                565                 570                 575     


Asp Pro Lys Phe Tyr Glu Ser Asn Ile Met Ser Thr Ile Asn Gly Tyr 
            580                 585                 590         


Val Pro Glu Ser Ile Thr Thr Leu Gly Phe Cys Phe Asp Asp Thr Val 
        595                 600                 605             


Gln Trp His Phe Cys Ser Val Gly Thr Gln Asn Glu Ile Leu Thr Ile 
    610                 615                 620                 


His Phe Thr Gly His Ser Phe Ile Tyr Gly Lys Arg His Glu Asp Thr 
625                 630                 635                 640 


Leu Thr Leu Phe Pro Met Arg Gly Glu Ser Val Thr Val Thr Met Asp 
                645                 650                 655     


Asn Val Gly Thr Trp Met Leu Thr Ser Met Asn Ser Ser Pro Arg Ser 
            660                 665                 670         


Lys Lys Leu Arg Leu Lys Phe Arg Asp Val Lys Cys Ile Pro Asp Asp 
        675                 680                 685             


Asp Glu Asp Ser Tyr Glu Ile Phe Glu Pro Pro Glu Ser Thr Val Met 
    690                 695                 700                 


Ala Thr Arg Lys Met His Asp Arg Leu Glu Pro Glu Asp Glu Glu Ser 
705                 710                 715                 720 


Asp Ala Asp Tyr Asp Tyr Gln Asn Arg Leu Ala Ala Ala Leu Gly Ile 
                725                 730                 735     


Arg Ser Phe Arg Asn Ser Ser Leu Asn Gln Glu Glu Glu Glu Phe Asn 
            740                 745                 750         


Leu Thr Ala Leu Ala Leu Glu Asn Gly Thr Glu Phe Val Ser Ser Asn 
        755                 760                 765             


Thr Asp Ile Ile Val Gly Ser Asn Tyr Ser Ser Pro Ser Asn Ile Ser 
    770                 775                 780                 


Lys Phe Thr Val Asn Asn Leu Ala Glu Pro Gln Lys Ala Pro Ser His 
785                 790                 795                 800 


Gln Gln Ala Thr Thr Ala Gly Ser Pro Leu Arg His Leu Ile Gly Lys 
                805                 810                 815     


Asn Ser Val Leu Asn Ser Ser Thr Ala Glu His Ser Ser Pro Tyr Ser 
            820                 825                 830         


Glu Asp Pro Ile Glu Asp Pro Leu Gln Pro Asp Val Thr Gly Ile Arg 
        835                 840                 845             


Leu Leu Ser Leu Gly Ala Gly Glu Phe Lys Ser Gln Glu His Ala Lys 
    850                 855                 860                 


His Lys Gly Pro Lys Val Glu Arg Asp Gln Ala Ala Lys His Arg Phe 
865                 870                 875                 880 


Ser Trp Met Lys Leu Leu Ala His Lys Val Gly Arg His Leu Ser Gln 
                885                 890                 895     


Asp Thr Gly Ser Pro Ser Gly Met Arg Pro Trp Glu Asp Leu Pro Ser 
            900                 905                 910         


Gln Asp Thr Gly Ser Pro Ser Arg Met Arg Pro Trp Lys Asp Pro Pro 
        915                 920                 925             


Ser Asp Leu Leu Leu Leu Lys Gln Ser Asn Ser Ser Lys Ile Leu Val 
    930                 935                 940                 


Gly Arg Trp His Leu Ala Ser Glu Lys Gly Ser Tyr Glu Ile Ile Gln 
945                 950                 955                 960 


Asp Thr Asp Glu Asp Thr Ala Val Asn Asn Trp Leu Ile Ser Pro Gln 
                965                 970                 975     


Asn Ala Ser Arg Ala Trp Gly Glu Ser Thr Pro Leu Ala Asn Lys Pro 
            980                 985                 990         


Gly Lys Gln Ser Gly His Pro Lys  Phe Pro Arg Val Arg  His Lys Ser 
        995                 1000                 1005             


Leu Gln  Val Arg Gln Asp Gly  Gly Lys Ser Arg Leu  Lys Lys Ser 
    1010                 1015                 1020             


Gln Phe  Leu Ile Lys Thr Arg  Lys Lys Lys Lys Glu  Lys His Thr 
    1025                 1030                 1035             


His His  Ala Pro Leu Ser Pro  Arg Thr Phe His Pro  Leu Arg Ser 
    1040                 1045                 1050             


Glu Ala  Tyr Asn Thr Phe Ser  Glu Arg Arg Leu Lys  His Ser Leu 
    1055                 1060                 1065             


Val Leu  His Lys Ser Asn Glu  Thr Ser Leu Pro Thr  Asp Leu Asn 
    1070                 1075                 1080             


Gln Thr  Leu Pro Ser Met Asp  Phe Gly Trp Ile Ala  Ser Leu Pro 
    1085                 1090                 1095             


Asp His  Asn Gln Asn Ser Ser  Asn Asp Thr Gly Gln  Ala Ser Cys 
    1100                 1105                 1110             


Pro Pro  Gly Leu Tyr Gln Thr  Val Pro Pro Glu Glu  His Tyr Gln 
    1115                 1120                 1125             


Thr Phe  Pro Ile Gln Asp Pro  Asp Gln Met His Ser  Thr Ser Asp 
    1130                 1135                 1140             


Pro Ser  His Arg Ser Ser Ser  Pro Glu Leu Ser Glu  Met Leu Glu 
    1145                 1150                 1155             


Tyr Asp  Arg Ser His Lys Ser  Phe Pro Thr Asp Ile  Ser Gln Met 
    1160                 1165                 1170             


Ser Pro  Ser Ser Glu His Glu  Val Trp Gln Thr Val  Ile Ser Pro 
    1175                 1180                 1185             


Asp Leu  Ser Gln Val Thr Leu  Ser Pro Glu Leu Ser  Gln Thr Asn 
    1190                 1195                 1200             


Leu Ser  Pro Asp Leu Ser His  Thr Thr Leu Ser Pro  Glu Leu Ile 
    1205                 1210                 1215             


Gln Arg  Asn Leu Ser Pro Ala  Leu Gly Gln Met Pro  Ile Ser Pro 
    1220                 1225                 1230             


Asp Leu  Ser His Thr Thr Leu  Ser Pro Asp Leu Ser  His Thr Thr 
    1235                 1240                 1245             


Leu Ser  Leu Asp Leu Ser Gln  Thr Asn Leu Ser Pro  Glu Leu Ser 
    1250                 1255                 1260             


Gln Thr  Asn Leu Ser Pro Ala  Leu Gly Gln Met Pro  Leu Ser Pro 
    1265                 1270                 1275             


Asp Leu  Ser His Thr Thr Leu  Ser Leu Asp Phe Ser  Gln Thr Asn 
    1280                 1285                 1290             


Leu Ser  Pro Glu Leu Ser His  Met Thr Leu Ser Pro  Glu Leu Ser 
    1295                 1300                 1305             


Gln Thr  Asn Leu Ser Pro Ala  Leu Gly Gln Met Pro  Ile Ser Pro 
    1310                 1315                 1320             


Asp Leu  Ser His Thr Thr Leu  Ser Leu Asp Phe Ser  Gln Thr Asn 
    1325                 1330                 1335             


Leu Ser  Pro Glu Leu Ser Gln  Thr Asn Leu Ser Pro  Ala Leu Gly 
    1340                 1345                 1350             


Gln Met  Pro Leu Ser Pro Asp  Pro Ser His Thr Thr  Leu Ser Leu 
    1355                 1360                 1365             


Asp Leu  Ser Gln Thr Asn Leu  Ser Pro Glu Leu Ser  Gln Thr Asn 
    1370                 1375                 1380             


Leu Ser  Pro Asp Leu Ser Glu  Met Pro Leu Phe Ala  Asp Leu Ser 
    1385                 1390                 1395             


Gln Ile  Pro Leu Thr Pro Asp  Leu Asp Gln Met Thr  Leu Ser Pro 
    1400                 1405                 1410             


Asp Leu  Gly Glu Thr Asp Leu  Ser Pro Asn Phe Gly  Gln Met Ser 
    1415                 1420                 1425             


Leu Ser  Pro Asp Leu Ser Gln  Val Thr Leu Ser Pro  Asp Ile Ser 
    1430                 1435                 1440             


Asp Thr  Thr Leu Leu Pro Asp  Leu Ser Gln Ile Ser  Pro Pro Pro 
    1445                 1450                 1455             


Asp Leu  Asp Gln Ile Phe Tyr  Pro Ser Glu Ser Ser  Gln Ser Leu 
    1460                 1465                 1470             


Leu Leu  Gln Glu Phe Asn Glu  Ser Phe Pro Tyr Pro  Asp Leu Gly 
    1475                 1480                 1485             


Gln Met  Pro Ser Pro Ser Ser  Pro Thr Leu Asn Asp  Thr Phe Leu 
    1490                 1495                 1500             


Ser Lys  Glu Phe Asn Pro Leu  Val Ile Val Gly Leu  Ser Lys Asp 
    1505                 1510                 1515             


Gly Thr  Asp Tyr Ile Glu Ile  Ile Pro Lys Glu Glu  Val Gln Ser 
    1520                 1525                 1530             


Ser Glu  Asp Asp Tyr Ala Glu  Ile Asp Tyr Val Pro  Tyr Asp Asp 
    1535                 1540                 1545             


Pro Tyr  Lys Thr Asp Val Arg  Thr Asn Ile Asn Ser  Ser Arg Asp 
    1550                 1555                 1560             


Pro Asp  Asn Ile Ala Ala Trp  Tyr Leu Arg Ser Asn  Asn Gly Asn 
    1565                 1570                 1575             


Arg Arg  Asn Tyr Tyr Ile Ala  Ala Glu Glu Ile Ser  Trp Asp Tyr 
    1580                 1585                 1590             


Ser Glu  Phe Val Gln Arg Glu  Thr Asp Ile Glu Asp  Ser Asp Asp 
    1595                 1600                 1605             


Ile Pro  Glu Asp Thr Thr Tyr  Lys Lys Val Val Phe  Arg Lys Tyr 
    1610                 1615                 1620             


Leu Asp  Ser Thr Phe Thr Lys  Arg Asp Pro Arg Gly  Glu Tyr Glu 
    1625                 1630                 1635             


Glu His  Leu Gly Ile Leu Gly  Pro Ile Ile Arg Ala  Glu Val Asp 
    1640                 1645                 1650             


Asp Val  Ile Gln Val Arg Phe  Lys Asn Leu Ala Ser  Arg Pro Tyr 
    1655                 1660                 1665             


Ser Leu  His Ala His Gly Leu  Ser Tyr Glu Lys Ser  Ser Glu Gly 
    1670                 1675                 1680             


Lys Thr  Tyr Glu Asp Asp Ser  Pro Glu Trp Phe Lys  Glu Asp Asn 
    1685                 1690                 1695             


Ala Val  Gln Pro Asn Ser Ser  Tyr Thr Tyr Val Trp  His Ala Thr 
    1700                 1705                 1710             


Glu Arg  Ser Gly Pro Glu Ser  Pro Gly Ser Ala Cys  Arg Ala Trp 
    1715                 1720                 1725             


Ala Tyr  Tyr Ser Ala Val Asn  Pro Glu Lys Asp Ile  His Ser Gly 
    1730                 1735                 1740             


Leu Ile  Gly Pro Leu Leu Ile  Cys Gln Lys Gly Ile  Leu His Lys 
    1745                 1750                 1755             


Asp Ser  Asn Met Pro Met Asp  Met Arg Glu Phe Val  Leu Leu Phe 
    1760                 1765                 1770             


Met Thr  Phe Asp Glu Lys Lys  Ser Trp Tyr Tyr Glu  Lys Lys Ser 
    1775                 1780                 1785             


Arg Ser  Ser Trp Arg Leu Thr  Ser Ser Glu Met Lys  Lys Ser His 
    1790                 1795                 1800             


Glu Phe  His Ala Ile Asn Gly  Met Ile Tyr Ser Leu  Pro Gly Leu 
    1805                 1810                 1815             


Lys Met  Tyr Glu Gln Glu Trp  Val Arg Leu His Leu  Leu Asn Ile 
    1820                 1825                 1830             


Gly Gly  Ser Gln Asp Ile His  Val Val His Phe His  Gly Gln Thr 
    1835                 1840                 1845             


Leu Leu  Glu Asn Gly Asn Lys  Gln His Gln Leu Gly  Val Trp Pro 
    1850                 1855                 1860             


Leu Leu  Pro Gly Ser Phe Lys  Thr Leu Glu Met Lys  Ala Ser Lys 
    1865                 1870                 1875             


Pro Gly  Trp Trp Leu Leu Asn  Thr Glu Val Gly Glu  Asn Gln Arg 
    1880                 1885                 1890             


Ala Gly  Met Gln Thr Pro Phe  Leu Ile Met Asp Arg  Asp Cys Arg 
    1895                 1900                 1905             


Met Pro  Met Gly Leu Ser Thr  Gly Ile Ile Ser Asp  Ser Gln Ile 
    1910                 1915                 1920             


Lys Ala  Ser Glu Phe Leu Gly  Tyr Trp Glu Pro Arg  Leu Ala Arg 
    1925                 1930                 1935             


Leu Asn  Asn Gly Gly Ser Tyr  Asn Ala Trp Ser Val  Glu Lys Leu 
    1940                 1945                 1950             


Ala Ala  Glu Phe Ala Ser Lys  Pro Trp Ile Gln Val  Asp Met Gln 
    1955                 1960                 1965             


Lys Glu  Val Ile Ile Thr Gly  Ile Gln Thr Gln Gly  Ala Lys His 
    1970                 1975                 1980             


Tyr Leu  Lys Ser Cys Tyr Thr  Thr Glu Phe Tyr Val  Ala Tyr Ser 
    1985                 1990                 1995             


Ser Asn  Gln Ile Asn Trp Gln  Ile Phe Lys Gly Asn  Ser Thr Arg 
    2000                 2005                 2010             


Asn Val  Met Tyr Phe Asn Gly  Asn Ser Asp Ala Ser  Thr Ile Lys 
    2015                 2020                 2025             


Glu Asn  Gln Phe Asp Pro Pro  Ile Val Ala Arg Tyr  Ile Arg Ile 
    2030                 2035                 2040             


Ser Pro  Thr Arg Ala Tyr Asn  Arg Pro Thr Leu Arg  Leu Glu Leu 
    2045                 2050                 2055             


Gln Gly  Cys Glu Val Asn Gly  Cys Ser Thr Pro Leu  Gly Met Glu 
    2060                 2065                 2070             


Asn Gly  Lys Ile Glu Asn Lys  Gln Ile Thr Ala Ser  Ser Phe Lys 
    2075                 2080                 2085             


Lys Ser  Trp Trp Gly Asp Tyr  Trp Glu Pro Phe Arg  Ala Arg Leu 
    2090                 2095                 2100             


Asn Ala  Gln Gly Arg Val Asn  Ala Trp Gln Ala Lys  Ala Asn Asn 
    2105                 2110                 2115             


Asn Lys  Gln Trp Leu Glu Ile  Asp Leu Leu Lys Ile  Lys Lys Ile 
    2120                 2125                 2130             


Thr Ala  Ile Ile Thr Gln Gly  Cys Lys Ser Leu Ser  Ser Glu Met 
    2135                 2140                 2145             


Tyr Val  Lys Ser Tyr Thr Ile  His Tyr Ser Glu Gln  Gly Val Glu 
    2150                 2155                 2160             


Trp Lys  Pro Tyr Arg Leu Lys  Ser Ser Met Val Asp  Lys Ile Phe 
    2165                 2170                 2175             


Glu Gly  Asn Thr Asn Thr Lys  Gly His Val Lys Asn  Phe Phe Asn 
    2180                 2185                 2190             


Pro Pro  Ile Ile Ser Arg Phe  Ile Arg Val Ile Pro  Lys Thr Trp 
    2195                 2200                 2205             


Asn Gln  Ser Ile Ala Leu Arg  Leu Glu Leu Phe Gly  Cys Asp Ile 
    2210                 2215                 2220             


Tyr 
    


<210>  646
<211>  553
<212>  PRT
<213>  Homo sapiens

<400>  646

Met Ala Ala Ser Lys Lys Ala Val Leu Gly Pro Leu Val Gly Ala Val 
1               5                   10                  15      


Asp Gln Gly Thr Ser Ser Thr Arg Phe Leu Val Phe Asn Ser Lys Thr 
            20                  25                  30          


Ala Glu Leu Leu Ser His His Gln Val Glu Ile Lys Gln Glu Phe Pro 
        35                  40                  45              


Arg Glu Gly Trp Val Glu Gln Asp Pro Lys Glu Ile Leu His Ser Val 
    50                  55                  60                  


Tyr Glu Cys Ile Glu Lys Thr Cys Glu Lys Leu Gly Gln Leu Asn Ile 
65                  70                  75                  80  


Asp Ile Ser Asn Ile Lys Ala Ile Gly Val Ser Asn Gln Arg Glu Thr 
                85                  90                  95      


Thr Val Val Trp Asp Lys Ile Thr Gly Glu Pro Leu Tyr Asn Ala Val 
            100                 105                 110         


Val Trp Leu Asp Leu Arg Thr Gln Ser Thr Val Glu Ser Leu Ser Lys 
        115                 120                 125             


Arg Ile Pro Gly Asn Asn Asn Phe Val Lys Ser Lys Thr Gly Leu Pro 
    130                 135                 140                 


Leu Ser Thr Tyr Phe Ser Ala Val Lys Leu Arg Trp Leu Leu Asp Asn 
145                 150                 155                 160 


Val Arg Lys Val Gln Lys Ala Val Glu Glu Lys Arg Ala Leu Phe Gly 
                165                 170                 175     


Thr Ile Asp Ser Trp Leu Ile Trp Ser Leu Thr Gly Gly Val Asn Gly 
            180                 185                 190         


Gly Val His Cys Thr Asp Val Thr Asn Ala Ser Arg Thr Met Leu Phe 
        195                 200                 205             


Asn Ile His Ser Leu Glu Trp Asp Lys Gln Leu Cys Glu Phe Phe Gly 
    210                 215                 220                 


Ile Pro Met Glu Ile Leu Pro Asn Val Arg Ser Ser Ser Glu Ile Tyr 
225                 230                 235                 240 


Gly Leu Met Lys Ala Gly Ala Leu Glu Gly Val Pro Ile Ser Gly Cys 
                245                 250                 255     


Leu Gly Asp Gln Ser Ala Ala Leu Val Gly Gln Met Cys Phe Gln Ile 
            260                 265                 270         


Gly Gln Ala Lys Asn Thr Tyr Gly Thr Gly Cys Phe Leu Leu Cys Asn 
        275                 280                 285             


Thr Gly His Lys Cys Val Phe Ser Asp His Gly Leu Leu Thr Thr Val 
    290                 295                 300                 


Ala Tyr Lys Leu Gly Arg Asp Lys Pro Val Tyr Tyr Ala Leu Glu Gly 
305                 310                 315                 320 


Ser Val Ala Ile Ala Gly Ala Val Ile Arg Trp Leu Arg Asp Asn Leu 
                325                 330                 335     


Gly Ile Ile Lys Thr Ser Glu Glu Ile Glu Lys Leu Ala Lys Glu Val 
            340                 345                 350         


Gly Thr Ser Tyr Gly Cys Tyr Phe Val Pro Ala Phe Ser Gly Leu Tyr 
        355                 360                 365             


Ala Pro Tyr Trp Glu Pro Ser Ala Arg Gly Ile Ile Cys Gly Leu Thr 
    370                 375                 380                 


Gln Phe Thr Asn Lys Cys His Ile Ala Phe Ala Ala Leu Glu Ala Val 
385                 390                 395                 400 


Cys Phe Gln Thr Arg Glu Ile Leu Asp Ala Met Asn Arg Asp Cys Gly 
                405                 410                 415     


Ile Pro Leu Ser His Leu Gln Val Asp Gly Gly Met Thr Ser Asn Lys 
            420                 425                 430         


Ile Leu Met Gln Leu Gln Ala Asp Ile Leu Tyr Ile Pro Val Val Lys 
        435                 440                 445             


Pro Ser Met Pro Glu Thr Thr Ala Leu Gly Ala Ala Met Ala Ala Gly 
    450                 455                 460                 


Ala Ala Glu Gly Val Gly Val Trp Ser Leu Glu Pro Glu Asp Leu Ser 
465                 470                 475                 480 


Ala Val Thr Met Glu Arg Phe Glu Pro Gln Ile Asn Ala Glu Glu Ser 
                485                 490                 495     


Glu Ile Arg Tyr Ser Thr Trp Lys Lys Ala Val Met Lys Ser Met Gly 
            500                 505                 510         


Trp Val Thr Thr Gln Ser Pro Glu Ser Gly Asp Pro Ser Ile Phe Cys 
        515                 520                 525             


Ser Leu Pro Leu Gly Phe Phe Ile Val Ser Ser Met Val Met Leu Ile 
    530                 535                 540                 


Gly Ala Arg Tyr Ile Ser Gly Ile Pro 
545                 550             


<210>  647
<211>  559
<212>  PRT
<213>  Homo sapiens

<400>  647

Met Ala Ala Ser Lys Lys Ala Val Leu Gly Pro Leu Val Gly Ala Val 
1               5                   10                  15      


Asp Gln Gly Thr Ser Ser Thr Arg Phe Leu Val Phe Asn Ser Lys Thr 
            20                  25                  30          


Ala Glu Leu Leu Ser His His Gln Val Glu Ile Lys Gln Glu Phe Pro 
        35                  40                  45              


Arg Glu Gly Trp Val Glu Gln Asp Pro Lys Glu Ile Leu His Ser Val 
    50                  55                  60                  


Tyr Glu Cys Ile Glu Lys Thr Cys Glu Lys Leu Gly Gln Leu Asn Ile 
65                  70                  75                  80  


Asp Ile Ser Asn Ile Lys Ala Ile Gly Val Ser Asn Gln Arg Glu Thr 
                85                  90                  95      


Thr Val Val Trp Asp Lys Ile Thr Gly Glu Pro Leu Tyr Asn Ala Val 
            100                 105                 110         


Val Trp Leu Asp Leu Arg Thr Gln Ser Thr Val Glu Ser Leu Ser Lys 
        115                 120                 125             


Arg Ile Pro Gly Asn Asn Asn Phe Val Lys Ser Lys Thr Gly Leu Pro 
    130                 135                 140                 


Leu Ser Thr Tyr Phe Ser Ala Val Lys Leu Arg Trp Leu Leu Asp Asn 
145                 150                 155                 160 


Val Arg Lys Val Gln Lys Ala Val Glu Glu Lys Arg Ala Leu Phe Gly 
                165                 170                 175     


Thr Ile Asp Ser Trp Leu Ile Trp Ser Leu Thr Gly Gly Val Asn Gly 
            180                 185                 190         


Gly Val His Cys Thr Asp Val Thr Asn Ala Ser Arg Thr Met Leu Phe 
        195                 200                 205             


Asn Ile His Ser Leu Glu Trp Asp Lys Gln Leu Cys Glu Phe Phe Gly 
    210                 215                 220                 


Ile Pro Met Glu Ile Leu Pro Asn Val Arg Ser Ser Ser Glu Ile Tyr 
225                 230                 235                 240 


Gly Leu Met Lys Ile Ser His Ser Val Lys Ala Gly Ala Leu Glu Gly 
                245                 250                 255     


Val Pro Ile Ser Gly Cys Leu Gly Asp Gln Ser Ala Ala Leu Val Gly 
            260                 265                 270         


Gln Met Cys Phe Gln Ile Gly Gln Ala Lys Asn Thr Tyr Gly Thr Gly 
        275                 280                 285             


Cys Phe Leu Leu Cys Asn Thr Gly His Lys Cys Val Phe Ser Asp His 
    290                 295                 300                 


Gly Leu Leu Thr Thr Val Ala Tyr Lys Leu Gly Arg Asp Lys Pro Val 
305                 310                 315                 320 


Tyr Tyr Ala Leu Glu Gly Ser Val Ala Ile Ala Gly Ala Val Ile Arg 
                325                 330                 335     


Trp Leu Arg Asp Asn Leu Gly Ile Ile Lys Thr Ser Glu Glu Ile Glu 
            340                 345                 350         


Lys Leu Ala Lys Glu Val Gly Thr Ser Tyr Gly Cys Tyr Phe Val Pro 
        355                 360                 365             


Ala Phe Ser Gly Leu Tyr Ala Pro Tyr Trp Glu Pro Ser Ala Arg Gly 
    370                 375                 380                 


Ile Ile Cys Gly Leu Thr Gln Phe Thr Asn Lys Cys His Ile Ala Phe 
385                 390                 395                 400 


Ala Ala Leu Glu Ala Val Cys Phe Gln Thr Arg Glu Ile Leu Asp Ala 
                405                 410                 415     


Met Asn Arg Asp Cys Gly Ile Pro Leu Ser His Leu Gln Val Asp Gly 
            420                 425                 430         


Gly Met Thr Ser Asn Lys Ile Leu Met Gln Leu Gln Ala Asp Ile Leu 
        435                 440                 445             


Tyr Ile Pro Val Val Lys Pro Ser Met Pro Glu Thr Thr Ala Leu Gly 
    450                 455                 460                 


Ala Ala Met Ala Ala Gly Ala Ala Glu Gly Val Gly Val Trp Ser Leu 
465                 470                 475                 480 


Glu Pro Glu Asp Leu Ser Ala Val Thr Met Glu Arg Phe Glu Pro Gln 
                485                 490                 495     


Ile Asn Ala Glu Glu Ser Glu Ile Arg Tyr Ser Thr Trp Lys Lys Ala 
            500                 505                 510         


Val Met Lys Ser Met Gly Trp Val Thr Thr Gln Ser Pro Glu Ser Gly 
        515                 520                 525             


Asp Pro Ser Ile Phe Cys Ser Leu Pro Leu Gly Phe Phe Ile Val Ser 
    530                 535                 540                 


Ser Met Val Met Leu Ile Gly Ala Arg Tyr Ile Ser Gly Ile Pro 
545                 550                 555                 


<210>  648
<211>  41
<212>  PRT
<213>  Homo sapiens

<400>  648

Ser Ala Arg Val Ala Lys Phe Arg Cys Cys Leu Ile Pro Asp Ser Asp 
1               5                   10                  15      


Ser Ile Thr Cys Ile Pro Leu Lys Pro Ala Phe Ser Gly Met Ala Pro 
            20                  25                  30          


Asp Val Ala Tyr Ser Thr Pro Thr Ser 
        35                  40      


<210>  649
<211>  57
<212>  PRT
<213>  Homo sapiens

<400>  649

Met Arg Leu His Tyr Arg Tyr Lys Glu Ala Ser Gly Tyr Phe His Thr 
1               5                   10                  15      


Leu Arg Ala Val Met Arg Asn Pro Glu Glu Asp Gly Lys Asp Thr Leu 
            20                  25                  30          


Gln Cys Ile Ala Glu Met Leu Gln Ile Thr Lys Gln Ala Met Gly Ser 
        35                  40                  45              


Asp Leu Pro Ile Ile Glu Lys Lys Leu 
    50                  55          


<210>  650
<211>  183
<212>  PRT
<213>  Homo sapiens

<400>  650

Met Pro Arg Ser His Arg Pro Pro Pro Thr Ala Gln Arg Ala Ala Thr 
1               5                   10                  15      


Ala Ala Ala Ala Glu Pro Lys Ser Glu Gly Val Val Ala Met Thr Phe 
            20                  25                  30          


Lys Ile Phe Leu Leu Phe Ala Gly Leu Met Val Lys Val Pro Val Gly 
        35                  40                  45              


Leu Tyr Phe Ser Cys Lys Leu Leu Leu Phe Gln Ser Leu Met Leu Met 
    50                  55                  60                  


Ser Pro Glu Asp Ser Gly Phe Tyr Ala Thr Ile Val Ala Val Val Gly 
65                  70                  75                  80  


Leu His Val Gln Gln Phe Ser Glu Cys Thr Leu Ile Asp Ala Thr His 
                85                  90                  95      


Arg Asp Val Asp Val Leu Leu Leu Leu Ser Asn Ser Ala Tyr Tyr Val 
            100                 105                 110         


Ala Tyr Tyr Asp Asp Glu Val Asp Lys Val Asn Gln Tyr Gln Arg Leu 
        115                 120                 125             


Ser Leu Glu Asn Leu Glu Lys Ile Glu Ile Gly Pro Glu Pro Thr Leu 
    130                 135                 140                 


Phe Gly Lys Pro Lys Phe Ser Cys Met Arg Leu His Tyr Arg Tyr Lys 
145                 150                 155                 160 


Glu Ala Ser Gly Tyr Phe His Thr Leu Arg Ala Val Met Arg Asn Pro 
                165                 170                 175     


Glu Glu Asp Gly Lys Asp Thr 
            180             


<210>  651
<211>  145
<212>  PRT
<213>  Homo sapiens

<400>  651

Met Ser Ala Val Leu Leu Leu Ala Leu Leu Gly Phe Ile Leu Pro Leu 
1               5                   10                  15      


Pro Gly Val Gln Ala Leu Leu Cys Gln Phe Gly Thr Val Gln His Val 
            20                  25                  30          


Trp Lys Val Ser Asp Leu Pro Arg Gln Trp Thr Pro Lys Asn Thr Ser 
        35                  40                  45              


Cys Asp Ser Gly Leu Gly Cys Gln Asp Thr Leu Met Leu Ile Glu Ser 
    50                  55                  60                  


Gly Pro Gln Val Ser Leu Val Leu Ser Lys Gly Cys Thr Glu Ala Lys 
65                  70                  75                  80  


Asp Gln Glu Pro Arg Val Thr Glu His Arg Met Gly Pro Gly Leu Ser 
                85                  90                  95      


Leu Ile Ser Tyr Thr Phe Val Cys Arg Gln Glu Asp Phe Cys Asn Asn 
            100                 105                 110         


Leu Val Asn Ser Leu Pro Leu Trp Ala Pro Gln Pro Pro Ala Asp Pro 
        115                 120                 125             


Met Met Gly Ala Ala Glu Gly Pro Phe Gly Lys Ala Glu Gln Val Asp 
    130                 135                 140                 


Ser 
145 


<210>  652
<211>  139
<212>  PRT
<213>  Homo sapiens

<400>  652

Met Ser Ala Val Leu Leu Leu Ala Leu Leu Gly Phe Ile Leu Pro Leu 
1               5                   10                  15      


Pro Gly Val Gln Ala Leu Leu Cys Gln Phe Gly Thr Val Gln His Val 
            20                  25                  30          


Trp Lys Val Ser Asp Leu Pro Arg Gln Trp Thr Pro Lys Asn Thr Ser 
        35                  40                  45              


Cys Asp Ser Gly Leu Gly Cys Gln Asp Thr Leu Met Leu Ile Glu Ser 
    50                  55                  60                  


Gly Pro Gln Val Ser Leu Val Leu Ser Lys Gly Cys Thr Glu Ala Lys 
65                  70                  75                  80  


Asp Gln Glu Pro Arg Val Thr Glu His Arg Met Gly Pro Gly Leu Ser 
                85                  90                  95      


Leu Ile Ser Tyr Thr Phe Val Cys Arg Gln Glu Asp Phe Cys Asn Asn 
            100                 105                 110         


Leu Val Asn Ser Leu Pro Leu Trp Ala Pro Gln Pro Pro Ala Gly Ala 
        115                 120                 125             


Cys Gly Arg Val Gly Arg Arg Gly Arg Gly Cys 
    130                 135                 


<210>  653
<211>  437
<212>  PRT
<213>  Homo sapiens

<400>  653

Met Ser Ala Val Leu Leu Leu Ala Leu Leu Gly Phe Ile Leu Pro Leu 
1               5                   10                  15      


Pro Gly Val Gln Ala Leu Leu Cys Gln Phe Gly Thr Val Gln His Val 
            20                  25                  30          


Trp Lys Val Ser Asp Leu Pro Arg Gln Trp Thr Pro Lys Asn Thr Ser 
        35                  40                  45              


Cys Asp Ser Gly Leu Gly Cys Gln Asp Thr Leu Met Leu Ile Glu Ser 
    50                  55                  60                  


Gly Pro Gln Val Ser Leu Val Leu Ser Lys Gly Cys Thr Glu Ala Lys 
65                  70                  75                  80  


Asp Gln Glu Pro Arg Val Thr Glu His Arg Met Gly Pro Gly Leu Ser 
                85                  90                  95      


Leu Ile Ser Tyr Thr Phe Val Cys Arg Gln Glu Asp Phe Cys Asn Asn 
            100                 105                 110         


Leu Val Asn Ser Leu Pro Leu Trp Ala Pro Gln Pro Pro Ala Asp Pro 
        115                 120                 125             


Gly Ser Leu Arg Cys Pro Val Cys Leu Ser Met Glu Gly Cys Leu Glu 
    130                 135                 140                 


Gly Thr Thr Glu Glu Ile Cys Pro Lys Gly Thr Thr His Cys Tyr Asp 
145                 150                 155                 160 


Gly Leu Leu Arg Leu Arg Gly Gly Gly Ile Phe Ser Asn Leu Arg Val 
                165                 170                 175     


Gln Gly Cys Met Pro Gln Pro Val Cys Asn Leu Leu Asn Gly Thr Gln 
            180                 185                 190         


Glu Ile Gly Pro Val Gly Met Thr Glu Asn Cys Asp Met Lys Asp Phe 
        195                 200                 205             


Leu Thr Cys His Arg Gly Thr Thr Ile Met Thr His Gly Asn Leu Ala 
    210                 215                 220                 


Gln Glu Pro Thr Asp Trp Thr Thr Ser Asn Thr Glu Met Cys Glu Val 
225                 230                 235                 240 


Gly Gln Val Cys Gln Glu Thr Leu Leu Leu Leu Asp Val Gly Leu Thr 
                245                 250                 255     


Ser Thr Leu Val Gly Thr Lys Gly Cys Ser Thr Val Gly Ala Gln Asn 
            260                 265                 270         


Ser Gln Lys Thr Thr Ile His Ser Ala Pro Pro Gly Val Leu Val Ala 
        275                 280                 285             


Ser Tyr Thr His Phe Cys Ser Ser Asp Leu Cys Asn Ser Ala Ser Ser 
    290                 295                 300                 


Ser Ser Val Leu Leu Asn Ser Leu Pro Pro Gln Ala Ala Pro Val Pro 
305                 310                 315                 320 


Gly Asp Arg Gln Cys Pro Thr Cys Val Gln Pro Leu Gly Thr Cys Ser 
                325                 330                 335     


Ser Gly Ser Pro Arg Met Thr Cys Pro Arg Gly Ala Thr His Cys Tyr 
            340                 345                 350         


Asp Gly Tyr Ile His Leu Ser Gly Gly Gly Leu Ser Thr Lys Met Ser 
        355                 360                 365             


Ile Gln Gly Cys Val Ala Gln Pro Ser Ser Phe Leu Leu Asn His Thr 
    370                 375                 380                 


Arg Gln Ile Gly Ile Phe Ser Ala Arg Glu Lys Arg Asp Val Gln Pro 
385                 390                 395                 400 


Pro Ala Ser Gln His Glu Gly Gly Gly Ala Glu Gly Leu Glu Ser Leu 
                405                 410                 415     


Thr Trp Gly Val Gly Leu Ala Leu Ala Pro Ala Leu Trp Trp Gly Val 
            420                 425                 430         


Val Cys Pro Ser Cys 
        435         


<210>  654
<211>  131
<212>  PRT
<213>  Homo sapiens

<400>  654

Met Ala Gly Val Lys Ala Leu Val Ala Leu Ser Phe Ser Gly Ala Ile 
1               5                   10                  15      


Gly Leu Thr Phe Leu Met Leu Gly Cys Ala Leu Glu Asp Tyr Gly Val 
            20                  25                  30          


Tyr Trp Pro Leu Phe Val Leu Ile Phe His Ala Ile Ser Pro Ile Pro 
        35                  40                  45              


His Phe Ile Ala Lys Arg Val Thr Tyr Asp Ser Asp Ala Thr Ser Ser 
    50                  55                  60                  


Ala Cys Arg Glu Leu Ala Tyr Phe Phe Thr Thr Gly Ile Val Val Ser 
65                  70                  75                  80  


Ala Phe Gly Phe Pro Val Ile Leu Ala Arg Val Ala Val Ile Lys Trp 
                85                  90                  95      


Gly Ala Cys Gly Leu Val Leu Ala Gly Asn Ala Val Ile Phe Leu Thr 
            100                 105                 110         


Ile Gln Gly Phe Phe Leu Ile Phe Gly Arg Gly Asp Asp Phe Ser Trp 
        115                 120                 125             


Glu Gln Trp 
    130     


<210>  655
<211>  140
<212>  PRT
<213>  Homo sapiens

<400>  655

Met Arg Asp Gly Lys Gly Phe Leu Gln Gly Phe Leu Tyr Phe Ala Leu 
1               5                   10                  15      


Val Ala Leu Ser Phe Ser Gly Ala Ile Gly Leu Thr Phe Leu Met Leu 
            20                  25                  30          


Gly Cys Ala Leu Glu Asp Tyr Gly Val Tyr Trp Pro Leu Phe Val Leu 
        35                  40                  45              


Ile Phe His Ala Ile Ser Pro Ile Pro His Phe Ile Ala Lys Arg Val 
    50                  55                  60                  


Thr Tyr Asp Ser Asp Ala Thr Ser Ser Ala Cys Arg Glu Leu Ala Tyr 
65                  70                  75                  80  


Phe Phe Thr Thr Gly Ile Val Val Ser Ala Phe Gly Phe Pro Val Ile 
                85                  90                  95      


Leu Ala Arg Val Ala Val Ile Lys Trp Gly Ala Cys Gly Leu Val Leu 
            100                 105                 110         


Ala Gly Asn Ala Val Ile Phe Leu Thr Ile Gln Gly Phe Phe Leu Ile 
        115                 120                 125             


Phe Gly Arg Gly Asp Asp Phe Ser Trp Glu Gln Trp 
    130                 135                 140 


<210>  656
<211>  140
<212>  PRT
<213>  Homo sapiens

<400>  656

Met Gln Phe Gly Glu Leu Leu Ala Ala Val Arg Lys Ala Gln Ala Asn 
1               5                   10                  15      


Val Met Leu Phe Leu Glu Glu Lys Glu Gln Ala Ala Leu Ser Gln Ala 
            20                  25                  30          


Asn Gly Ile Lys Ala His Leu Glu Tyr Arg Ser Ala Glu Met Glu Lys 
        35                  40                  45              


Ser Lys Gln Glu Leu Glu Arg Met Ala Ala Ile Ser Asn Thr Val Gln 
    50                  55                  60                  


Phe Leu Glu Met Arg Met Thr Ser Arg Leu Thr Arg Thr Gln His Thr 
65                  70                  75                  80  


Ser Ile Ser Gly Cys Arg Arg Arg Thr Ala Arg Ser Pro Thr Pro Arg 
                85                  90                  95      


Pro Gly Ser Ile Pro Thr Arg Thr Ser Pro Ala Gly Ser Cys Thr Gly 
            100                 105                 110         


Gly Arg Cys Cys Pro Ser Arg Val Cys Thr Cys Thr Gly Thr Ile Leu 
        115                 120                 125             


Arg Trp Arg Ser Ser Gly Gln Ala Pro Met Leu Ala 
    130                 135                 140 


<210>  657
<211>  205
<212>  PRT
<213>  Homo sapiens

<400>  657

Met Thr Pro Pro Glu Arg Leu Phe Leu Pro Arg Val Cys Gly Thr Thr 
1               5                   10                  15      


Leu His Leu Leu Leu Leu Gly Leu Leu Leu Val Leu Leu Pro Gly Ala 
            20                  25                  30          


Gln Gly Leu Pro Gly Val Gly Leu Thr Pro Ser Ala Ala Gln Thr Ala 
        35                  40                  45              


Arg Gln His Pro Lys Met His Leu Ala His Ser Thr Leu Lys Pro Ala 
    50                  55                  60                  


Ala His Leu Ile Gly Asp Pro Ser Lys Gln Asn Ser Leu Leu Trp Arg 
65                  70                  75                  80  


Ala Asn Thr Asp Arg Ala Phe Leu Gln Asp Gly Phe Ser Leu Ser Asn 
                85                  90                  95      


Asn Ser Leu Leu Val Pro Thr Ser Gly Ile Tyr Phe Val Tyr Ser Gln 
            100                 105                 110         


Val Val Phe Ser Gly Lys Ala Tyr Ser Pro Lys Ala Thr Ser Ser Pro 
        115                 120                 125             


Leu Tyr Leu Ala His Glu Val Gln Leu Phe Ser Ser Gln Tyr Pro Phe 
    130                 135                 140                 


His Val Pro Leu Leu Ser Ser Gln Lys Met Val Tyr Pro Gly Leu Gln 
145                 150                 155                 160 


Glu Pro Trp Leu His Ser Met Tyr His Gly Ala Ala Phe Gln Leu Thr 
                165                 170                 175     


Gln Gly Asp Gln Leu Ser Thr His Thr Asp Gly Ile Pro His Leu Val 
            180                 185                 190         


Leu Ser Pro Ser Thr Val Phe Phe Gly Ala Phe Ala Leu 
        195                 200                 205 


<210>  658
<211>  205
<212>  PRT
<213>  Homo sapiens

<400>  658

Met Thr Pro Pro Glu Arg Leu Phe Leu Pro Arg Val Cys Gly Thr Thr 
1               5                   10                  15      


Leu His Leu Leu Leu Leu Gly Leu Leu Leu Val Leu Leu Pro Gly Ala 
            20                  25                  30          


Gln Gly Leu Pro Gly Val Gly Leu Thr Pro Ser Ala Ala Gln Thr Ala 
        35                  40                  45              


Arg Gln His Pro Lys Met His Leu Ala His Ser Thr Leu Lys Pro Ala 
    50                  55                  60                  


Ala His Leu Ile Gly Asp Pro Ser Lys Gln Asn Ser Leu Leu Trp Arg 
65                  70                  75                  80  


Ala Asn Thr Asp Arg Ala Phe Leu Gln Asp Gly Phe Ser Leu Ser Asn 
                85                  90                  95      


Asn Ser Leu Leu Val Pro Thr Ser Gly Ile Tyr Phe Val Tyr Ser Gln 
            100                 105                 110         


Val Val Phe Ser Gly Lys Ala Tyr Ser Pro Lys Ala Thr Ser Ser Pro 
        115                 120                 125             


Leu Tyr Leu Ala His Glu Val Gln Leu Phe Ser Ser Gln Tyr Pro Phe 
    130                 135                 140                 


His Val Pro Leu Leu Ser Ser Gln Lys Met Val Tyr Pro Gly Leu Gln 
145                 150                 155                 160 


Glu Pro Trp Leu His Ser Met Tyr His Gly Ala Ala Phe Gln Leu Thr 
                165                 170                 175     


Gln Gly Asp Gln Leu Ser Thr His Thr Asp Gly Ile Pro His Leu Val 
            180                 185                 190         


Leu Ser Pro Ser Thr Val Phe Phe Gly Ala Phe Ala Leu 
        195                 200                 205 


<210>  659
<211>  1015
<212>  PRT
<213>  Homo sapiens

<400>  659

Met Leu Thr Ala Leu Ala Pro Pro Ala Leu Pro Gly Ile Pro Arg Gln 
1               5                   10                  15      


Leu Pro Thr Ala Pro Ala Arg Arg Gln Asp Ser Ser Gly Ser Ser Gly 
            20                  25                  30          


Ser Tyr Tyr Thr Ala Pro Gly Ser Pro Glu Pro Pro Asp Val Gly Pro 
        35                  40                  45              


Asp Ala Lys Gly Pro Ala Asn Trp Pro Trp Val Ala Pro Gly Arg Gly 
    50                  55                  60                  


Ala Gly Ala Gln Pro Arg Leu Ser Val Ser Ala Gln Asn Ser Arg Gln 
65                  70                  75                  80  


Arg His Gly Pro Gly Ser Gly Phe Pro Arg Gly Pro Gly Ser Gly Pro 
                85                  90                  95      


Arg Pro Pro Gln Pro Gln Leu Arg Thr Leu Pro Ser Gly Glu Met Glu 
            100                 105                 110         


Val Ile Phe Gly Val Gly Pro Leu Phe Gly Cys Ser Gly Ala Asp Asp 
        115                 120                 125             


Arg Glu Ala Gln Gln Gln Phe Thr Glu Pro Ala Phe Ile Ser Pro Leu 
    130                 135                 140                 


Pro Pro Gly Pro Ala Ser Pro Ala Ala Val Pro Arg Gln Ser Gln Val 
145                 150                 155                 160 


Pro Asp Gly Gly Ser Arg Trp Ala Thr Tyr Leu Glu Leu Arg Pro Arg 
                165                 170                 175     


Gly Pro Ser Pro Ala Ala Pro Ala Gln Phe Glu Cys Val Glu Val Ala 
            180                 185                 190         


Leu Glu Glu Gly Ala Ala Pro Ala Arg Pro Arg Thr Val Pro Lys Arg 
        195                 200                 205             


Gln Ile Glu Leu Arg Pro Arg Pro Gln Ser Pro Pro Arg Ala Ala Gly 
    210                 215                 220                 


Ala Pro Arg Pro Arg Leu Leu Leu Arg Thr Gly Ser Leu Asp Glu Ser 
225                 230                 235                 240 


Leu Gly Pro Leu Gln Ala Ala Ala Gly Phe Val Gln Thr Ala Leu Ala 
                245                 250                 255     


Arg Lys Leu Ser Pro Glu Ala Pro Ala Pro Ser Ser Ala Thr Phe Gly 
            260                 265                 270         


Ser Thr Gly Arg Ser Glu Pro Glu Thr Arg Glu Thr Ala Arg Ser Thr 
        275                 280                 285             


His Val Val Leu Glu Lys Ala Lys Ser Arg Pro Leu Arg Val Arg Asp 
    290                 295                 300                 


Asn Ser Ala Pro Ala Lys Ala Pro Arg Pro Trp Pro Ser Leu Arg Glu 
305                 310                 315                 320 


Arg Ala Ile Arg Arg Asp Lys Pro Ala Pro Gly Thr Glu Pro Leu Gly 
                325                 330                 335     


Pro Val Ser Ser Ser Ile Phe Leu Gln Ser Glu Glu Lys Ile Gln Glu 
            340                 345                 350         


Ala Arg Lys Thr Arg Phe Pro Arg Glu Ala Pro Asp Arg Thr Val Gln 
        355                 360                 365             


Arg Ala Arg Ser Pro Pro Phe Glu Cys Arg Ile Pro Ser Glu Val Pro 
    370                 375                 380                 


Ser Arg Ala Val Arg Pro Arg Ser Pro Ser Pro Pro Arg Gln Thr Pro 
385                 390                 395                 400 


Asn Gly Ala Val Arg Gly Pro Arg Cys Pro Ser Pro Gln Asn Leu Ser 
                405                 410                 415     


Pro Trp Asp Arg Thr Thr Arg Arg Val Ser Ser Pro Leu Phe Pro Glu 
            420                 425                 430         


Ala Ser Ser Glu Trp Glu Asn Gln Asn Pro Ala Val Glu Glu Thr Val 
        435                 440                 445             


Ser Arg Arg Ser Pro Ser Pro Pro Ile Leu Ser Gln Trp Asn Gln Cys 
    450                 455                 460                 


Val Ala Gly Glu Arg Ser Pro Ser Leu Glu Ala Pro Ser Leu Trp Glu 
465                 470                 475                 480 


Ile Pro His Ser Ala Val Ala Asp Ala Val Glu Pro Arg Ser Ser Pro 
                485                 490                 495     


Ser Pro Pro Ala Phe Phe Pro Trp Glu Ala Pro Asp Arg Pro Ile Gly 
            500                 505                 510         


Thr Trp Gly Pro Ser Pro Gln Glu Thr Trp Asp Pro Met Gly Pro Gly 
        515                 520                 525             


Ser Ser Ile Ala Phe Thr Gln Glu Ala Gln Asn Gly Leu Thr Gln Glu 
    530                 535                 540                 


Glu Leu Ala Pro Pro Thr Pro Ser Ala Pro Gly Thr Pro Glu Pro Thr 
545                 550                 555                 560 


Glu Met Gln Ser Pro Ser Thr Arg Glu Ile Ser Asp Leu Ala Phe Gly 
                565                 570                 575     


Gly Ser Gln Gln Ser Pro Glu Val Ala Ala Pro Glu Pro Pro Gly Ser 
            580                 585                 590         


His Pro Val Gly Thr Leu Asp Ala Asp Lys Cys Pro Glu Val Leu Gly 
        595                 600                 605             


Pro Gly Glu Ala Ala Ser Gly Arg Pro Arg Met Ala Ile Pro Arg Pro 
    610                 615                 620                 


Arg Asp Val Arg Lys Leu Val Lys Thr Thr Tyr Ala Pro Gly Phe Pro 
625                 630                 635                 640 


Ala Gly Ala Gln Gly Ser Gly Leu Pro Ala Pro Pro Ala Asp Pro Cys 
                645                 650                 655     


Gly Glu Glu Gly Gly Glu Ser Lys Thr Gln Glu Pro Pro Ala Leu Gly 
            660                 665                 670         


Pro Pro Ala Pro Ala His Tyr Thr Ser Val Phe Ile Lys Asp Phe Leu 
        675                 680                 685             


Pro Val Val Pro His Pro Tyr Glu Pro Pro Glu Pro Ser Phe Asp Thr 
    690                 695                 700                 


Val Ala Arg Asp Ala Ser Gln Pro Asn Gly Val Leu Arg Arg Arg Ala 
705                 710                 715                 720 


Glu Asn Ser Thr Ala Lys Pro Phe Lys Arg Thr Glu Ile Arg Leu Pro 
                725                 730                 735     


Gly Ala Leu Ala Leu Gly Arg Arg Pro Glu Val Thr Ser Arg Val Arg 
            740                 745                 750         


Ala Arg Gly Pro Gly Gly Glu Asn Arg Asp Val Glu Ala Gln Arg Leu 
        755                 760                 765             


Val Pro Asp Gly Asp Gly Arg Thr Ser Pro Leu Gly Gly Ala Arg Ser 
    770                 775                 780                 


Ser Ser Gln Arg Ser Pro Val Gly Pro Ala Gly Val Arg Ser Pro Arg 
785                 790                 795                 800 


Pro Gly Ser Pro Gln Met Gln Ala Ser Pro Ser Pro Gly Ile Ala Pro 
                805                 810                 815     


Lys Pro Lys Thr Pro Pro Thr Ala Pro Glu Pro Ala Ala Ala Val Gln 
            820                 825                 830         


Ala Pro Leu Pro Arg Glu Pro Leu Ala Leu Ala Gly Arg Thr Ala Pro 
        835                 840                 845             


Ala Gln Pro Arg Ala Ala Ser Ala Pro Pro Thr Asp Arg Ser Pro Gln 
    850                 855                 860                 


Ser Pro Ser Gln Gly Ala Arg Arg Gln Pro Gly Ala Ala Pro Leu Gly 
865                 870                 875                 880 


Lys Val Leu Val Asp Pro Glu Ser Gly Arg Tyr Tyr Phe Val Glu Ala 
                885                 890                 895     


Pro Arg Gln Pro Arg Leu Arg Val Leu Phe Asp Pro Glu Ser Gly Gln 
            900                 905                 910         


Tyr Val Glu Val Leu Leu Pro Pro Ser Ser Pro Gly Pro Pro His Arg 
        915                 920                 925             


Val Tyr Thr Pro Leu Ala Leu Gly Leu Gly Leu Tyr Pro Pro Ala Tyr 
    930                 935                 940                 


Gly Pro Ile Pro Ser Leu Ser Leu Pro Pro Ser Pro Gly Pro Gln Ala 
945                 950                 955                 960 


Leu Gly Ser Pro Gln Leu Pro Trp Val Ser Glu Ala Gly Pro Leu Asp 
                965                 970                 975     


Gly Thr Tyr Tyr Leu Pro Val Ser Gly Thr Pro Asn Pro Ala Pro Pro 
            980                 985                 990         


Leu Leu Leu Cys Ala Pro Pro Ser  Ser Ser Gly Pro Thr  Gln Pro Gly 
        995                 1000                 1005             


Lys Gly  Ser Leu Phe Pro Leu  
    1010                 1015 


<210>  660
<211>  418
<212>  PRT
<213>  Homo sapiens

<400>  660

Met Asp Met Leu His Pro Ser Ser Val Ser Thr Thr Ser Glu Pro Glu 
1               5                   10                  15      


Asn Ala Ser Ser Ala Trp Pro Pro Asp Ala Thr Leu Gly Asn Val Ser 
            20                  25                  30          


Ala Gly Pro Ser Pro Ala Gly Leu Ala Val Ser Gly Val Leu Ile Pro 
        35                  40                  45              


Leu Val Tyr Leu Val Val Cys Val Val Gly Leu Leu Gly Asn Ser Leu 
    50                  55                  60                  


Val Ile Tyr Val Val Leu Arg His Thr Ala Ser Pro Ser Val Thr Asn 
65                  70                  75                  80  


Val Tyr Ile Leu Asn Leu Ala Leu Ala Asp Glu Leu Phe Met Leu Gly 
                85                  90                  95      


Leu Pro Phe Leu Ala Ala Gln Asn Ala Leu Ser Tyr Trp Pro Phe Gly 
            100                 105                 110         


Ser Leu Met Cys Arg Leu Val Met Ala Val Asp Gly Ile Asn Gln Phe 
        115                 120                 125             


Thr Ser Ile Phe Cys Leu Thr Val Met Ser Val Asp Arg Tyr Leu Ala 
    130                 135                 140                 


Val Val His Pro Thr Arg Ser Ala Arg Trp Arg Thr Ala Pro Val Ala 
145                 150                 155                 160 


Arg Thr Val Ser Ala Ala Val Trp Val Ala Ser Ala Val Val Val Leu 
                165                 170                 175     


Pro Val Val Val Phe Ser Gly Val Pro Arg Gly Met Ser Thr Cys His 
            180                 185                 190         


Met Gln Trp Pro Glu Pro Ala Ala Ala Trp Arg Ala Gly Phe Ile Ile 
        195                 200                 205             


Tyr Thr Ala Ala Leu Gly Phe Phe Gly Pro Leu Leu Val Ile Cys Leu 
    210                 215                 220                 


Cys Tyr Leu Leu Ile Val Val Lys Val Arg Ser Ala Gly Arg Arg Val 
225                 230                 235                 240 


Trp Ala Pro Ser Cys Gln Arg Arg Arg Arg Ser Glu Arg Arg Val Thr 
                245                 250                 255     


Arg Met Val Val Ala Val Val Ala Leu Phe Val Leu Cys Trp Met Pro 
            260                 265                 270         


Phe Tyr Val Leu Asn Ile Val Asn Val Val Cys Pro Leu Pro Glu Glu 
        275                 280                 285             


Pro Ala Phe Phe Gly Leu Tyr Phe Leu Val Val Ala Leu Pro Tyr Ala 
    290                 295                 300                 


Asn Ser Cys Ala Asn Pro Ile Leu Tyr Gly Phe Leu Ser Tyr Arg Phe 
305                 310                 315                 320 


Lys Gln Gly Phe Arg Arg Val Leu Leu Arg Pro Ser Arg Arg Val Arg 
                325                 330                 335     


Ser Gln Glu Pro Thr Val Gly Pro Pro Glu Lys Thr Glu Glu Glu Asp 
            340                 345                 350         


Glu Glu Glu Glu Asp Gly Glu Glu Ser Arg Glu Gly Gly Lys Gly Lys 
        355                 360                 365             


Glu Met Asn Gly Arg Val Ser Gln Ile Thr Gln Pro Gly Thr Ser Gly 
    370                 375                 380                 


Gln Glu Arg Pro Pro Ser Arg Val Ala Ser Lys Glu Gln Gln Leu Leu 
385                 390                 395                 400 


Pro Gln Glu Ala Ser Thr Gly Glu Lys Ser Ser Thr Met Arg Ile Ser 
                405                 410                 415     


Tyr Leu 
        


<210>  661
<211>  418
<212>  PRT
<213>  Homo sapiens

<400>  661

Met Asp Met Leu His Pro Ser Ser Val Ser Thr Thr Ser Glu Pro Glu 
1               5                   10                  15      


Asn Ala Ser Ser Ala Trp Pro Pro Asp Ala Thr Leu Gly Asn Val Ser 
            20                  25                  30          


Ala Gly Pro Ser Pro Ala Gly Leu Ala Val Ser Gly Val Leu Ile Pro 
        35                  40                  45              


Leu Val Tyr Leu Val Val Cys Val Val Gly Leu Leu Gly Asn Ser Leu 
    50                  55                  60                  


Val Ile Tyr Val Val Leu Arg His Thr Ala Ser Pro Ser Val Thr Asn 
65                  70                  75                  80  


Val Tyr Ile Leu Asn Leu Ala Leu Ala Asp Glu Leu Phe Met Leu Gly 
                85                  90                  95      


Leu Pro Phe Leu Ala Ala Gln Asn Ala Leu Ser Tyr Trp Pro Phe Gly 
            100                 105                 110         


Ser Leu Met Cys Arg Leu Val Met Ala Val Asp Gly Ile Asn Gln Phe 
        115                 120                 125             


Thr Ser Ile Phe Cys Leu Thr Val Met Ser Val Asp Arg Tyr Leu Ala 
    130                 135                 140                 


Val Val His Pro Thr Arg Ser Ala Arg Trp Arg Thr Ala Pro Val Ala 
145                 150                 155                 160 


Arg Thr Val Ser Ala Ala Val Trp Val Ala Ser Ala Val Val Val Leu 
                165                 170                 175     


Pro Val Val Val Phe Ser Gly Val Pro Arg Gly Met Ser Thr Cys His 
            180                 185                 190         


Met Gln Trp Pro Glu Pro Ala Ala Ala Trp Arg Ala Gly Phe Ile Ile 
        195                 200                 205             


Tyr Thr Ala Ala Leu Gly Phe Phe Gly Pro Leu Leu Val Ile Cys Leu 
    210                 215                 220                 


Cys Tyr Leu Leu Ile Val Val Lys Val Arg Ser Ala Gly Arg Arg Val 
225                 230                 235                 240 


Trp Ala Pro Ser Cys Gln Arg Arg Arg Arg Ser Glu Arg Arg Val Thr 
                245                 250                 255     


Arg Met Val Val Ala Val Val Ala Leu Phe Val Leu Cys Trp Met Pro 
            260                 265                 270         


Phe Tyr Val Leu Asn Ile Val Asn Val Val Cys Pro Leu Pro Glu Glu 
        275                 280                 285             


Pro Ala Phe Phe Gly Leu Tyr Phe Leu Val Val Ala Leu Pro Tyr Ala 
    290                 295                 300                 


Asn Ser Cys Ala Asn Pro Ile Leu Tyr Gly Phe Leu Ser Tyr Arg Phe 
305                 310                 315                 320 


Lys Gln Gly Phe Arg Arg Val Leu Leu Arg Pro Ser Arg Arg Val Arg 
                325                 330                 335     


Ser Gln Glu Pro Thr Val Gly Pro Pro Glu Lys Thr Glu Glu Glu Asp 
            340                 345                 350         


Glu Glu Glu Glu Asp Gly Glu Glu Ser Arg Glu Gly Gly Lys Gly Lys 
        355                 360                 365             


Glu Met Asn Gly Arg Val Ser Gln Ile Thr Gln Pro Gly Thr Ser Gly 
    370                 375                 380                 


Gln Glu Arg Pro Pro Ser Arg Val Ala Ser Lys Glu Gln Gln Leu Leu 
385                 390                 395                 400 


Pro Gln Glu Ala Ser Thr Gly Glu Lys Ser Ser Thr Met Arg Ile Ser 
                405                 410                 415     


Tyr Leu 
        


<210>  662
<211>  526
<212>  PRT
<213>  Homo sapiens

<400>  662

Met Gly His Leu Ser Ala Pro Leu His Arg Val Arg Val Pro Trp Gln 
1               5                   10                  15      


Gly Leu Leu Leu Thr Ala Ser Leu Leu Thr Phe Trp Asn Pro Pro Thr 
            20                  25                  30          


Thr Ala Gln Leu Thr Thr Glu Ser Met Pro Phe Asn Val Ala Glu Gly 
        35                  40                  45              


Lys Glu Val Leu Leu Leu Val His Asn Leu Pro Gln Gln Leu Phe Gly 
    50                  55                  60                  


Tyr Ser Trp Tyr Lys Gly Glu Arg Val Asp Gly Asn Arg Gln Ile Val 
65                  70                  75                  80  


Gly Tyr Ala Ile Gly Thr Gln Gln Ala Thr Pro Gly Pro Ala Asn Ser 
                85                  90                  95      


Gly Arg Glu Thr Ile Tyr Pro Asn Ala Ser Leu Leu Ile Gln Asn Val 
            100                 105                 110         


Thr Gln Asn Asp Thr Gly Phe Tyr Thr Leu Gln Val Ile Lys Ser Asp 
        115                 120                 125             


Leu Val Asn Glu Glu Ala Thr Gly Gln Phe His Val Tyr Pro Glu Leu 
    130                 135                 140                 


Pro Lys Pro Ser Ile Ser Ser Asn Asn Ser Asn Pro Val Glu Asp Lys 
145                 150                 155                 160 


Asp Ala Val Ala Phe Thr Cys Glu Pro Glu Thr Gln Asp Thr Thr Tyr 
                165                 170                 175     


Leu Trp Trp Ile Asn Asn Gln Ser Leu Pro Val Ser Pro Arg Leu Gln 
            180                 185                 190         


Leu Ser Asn Gly Asn Arg Thr Leu Thr Leu Leu Ser Val Thr Arg Asn 
        195                 200                 205             


Asp Thr Gly Pro Tyr Glu Cys Glu Ile Gln Asn Pro Val Ser Ala Asn 
    210                 215                 220                 


Arg Ser Asp Pro Val Thr Leu Asn Val Thr Tyr Gly Pro Asp Thr Pro 
225                 230                 235                 240 


Thr Ile Ser Pro Ser Asp Thr Tyr Tyr Arg Pro Gly Ala Asn Leu Ser 
                245                 250                 255     


Leu Ser Cys Tyr Ala Ala Ser Asn Pro Pro Ala Gln Tyr Ser Trp Leu 
            260                 265                 270         


Ile Asn Gly Thr Phe Gln Gln Ser Thr Gln Glu Leu Phe Ile Pro Asn 
        275                 280                 285             


Ile Thr Val Asn Asn Ser Gly Ser Tyr Thr Cys His Ala Asn Asn Ser 
    290                 295                 300                 


Val Thr Gly Cys Asn Arg Thr Thr Val Lys Thr Ile Ile Val Thr Glu 
305                 310                 315                 320 


Leu Ser Pro Val Val Ala Lys Pro Gln Ile Lys Ala Ser Lys Thr Thr 
                325                 330                 335     


Val Thr Gly Asp Lys Asp Ser Val Asn Leu Thr Cys Ser Thr Asn Asp 
            340                 345                 350         


Thr Gly Ile Ser Ile Arg Trp Phe Phe Lys Asn Gln Ser Leu Pro Ser 
        355                 360                 365             


Ser Glu Arg Met Lys Leu Ser Gln Gly Asn Thr Thr Leu Ser Ile Asn 
    370                 375                 380                 


Pro Val Lys Arg Glu Asp Ala Gly Thr Tyr Trp Cys Glu Val Phe Asn 
385                 390                 395                 400 


Pro Ile Ser Lys Asn Gln Ser Asp Pro Ile Met Leu Asn Val Asn Tyr 
                405                 410                 415     


Asn Ala Leu Pro Gln Glu Asn Gly Leu Ser Pro Gly Ala Ile Ala Gly 
            420                 425                 430         


Ile Val Ile Gly Val Val Ala Leu Val Ala Leu Ile Ala Val Ala Leu 
        435                 440                 445             


Ala Cys Phe Leu His Phe Gly Lys Thr Gly Arg Ala Ser Asp Gln Arg 
    450                 455                 460                 


Asp Leu Thr Glu His Lys Pro Ser Val Ser Asn His Thr Gln Asp His 
465                 470                 475                 480 


Ser Asn Asp Pro Pro Asn Lys Met Asn Glu Val Thr Tyr Ser Thr Leu 
                485                 490                 495     


Asn Phe Glu Ala Gln Gln Pro Thr Gln Pro Thr Ser Ala Ser Pro Ser 
            500                 505                 510         


Leu Thr Ala Thr Glu Ile Ile Tyr Ser Glu Val Lys Lys Gln 
        515                 520                 525     


<210>  663
<211>  430
<212>  PRT
<213>  Homo sapiens

<400>  663

Met Gly His Leu Ser Ala Pro Leu His Arg Val Arg Val Pro Trp Gln 
1               5                   10                  15      


Gly Leu Leu Leu Thr Ala Ser Leu Leu Thr Phe Trp Asn Pro Pro Thr 
            20                  25                  30          


Thr Ala Gln Leu Thr Thr Glu Ser Met Pro Phe Asn Val Ala Glu Gly 
        35                  40                  45              


Lys Glu Val Leu Leu Leu Val His Asn Leu Pro Gln Gln Leu Phe Gly 
    50                  55                  60                  


Tyr Ser Trp Tyr Lys Gly Glu Arg Val Asp Gly Asn Arg Gln Ile Val 
65                  70                  75                  80  


Gly Tyr Ala Ile Gly Thr Gln Gln Ala Thr Pro Gly Pro Ala Asn Ser 
                85                  90                  95      


Gly Arg Glu Thr Ile Tyr Pro Asn Ala Ser Leu Leu Ile Gln Asn Val 
            100                 105                 110         


Thr Gln Asn Asp Thr Gly Phe Tyr Thr Leu Gln Val Ile Lys Ser Asp 
        115                 120                 125             


Leu Val Asn Glu Glu Ala Thr Gly Gln Phe His Val Tyr Pro Glu Leu 
    130                 135                 140                 


Pro Lys Pro Ser Ile Ser Ser Asn Asn Ser Asn Pro Val Glu Asp Lys 
145                 150                 155                 160 


Asp Ala Val Ala Phe Thr Cys Glu Pro Glu Thr Gln Asp Thr Thr Tyr 
                165                 170                 175     


Leu Trp Trp Ile Asn Asn Gln Ser Leu Pro Val Ser Pro Arg Leu Gln 
            180                 185                 190         


Leu Ser Asn Gly Asn Arg Thr Leu Thr Leu Leu Ser Val Thr Arg Asn 
        195                 200                 205             


Asp Thr Gly Pro Tyr Glu Cys Glu Ile Gln Asn Pro Val Ser Ala Asn 
    210                 215                 220                 


Arg Ser Asp Pro Val Thr Leu Asn Val Thr Tyr Gly Pro Asp Thr Pro 
225                 230                 235                 240 


Thr Ile Ser Pro Ser Asp Thr Tyr Tyr Arg Pro Gly Ala Asn Leu Ser 
                245                 250                 255     


Leu Ser Cys Tyr Ala Ala Ser Asn Pro Pro Ala Gln Tyr Ser Trp Leu 
            260                 265                 270         


Ile Asn Gly Thr Phe Gln Gln Ser Thr Gln Glu Leu Phe Ile Pro Asn 
        275                 280                 285             


Ile Thr Val Asn Asn Ser Gly Ser Tyr Thr Cys His Ala Asn Asn Ser 
    290                 295                 300                 


Val Thr Gly Cys Asn Arg Thr Thr Val Lys Thr Ile Ile Val Thr Asp 
305                 310                 315                 320 


Asn Ala Leu Pro Gln Glu Asn Gly Leu Ser Pro Gly Ala Ile Ala Gly 
                325                 330                 335     


Ile Val Ile Gly Val Val Ala Leu Val Ala Leu Ile Ala Val Ala Leu 
            340                 345                 350         


Ala Cys Phe Leu His Phe Gly Lys Thr Gly Arg Ala Ser Asp Gln Arg 
        355                 360                 365             


Asp Leu Thr Glu His Lys Pro Ser Val Ser Asn His Thr Gln Asp His 
    370                 375                 380                 


Ser Asn Asp Pro Pro Asn Lys Met Asn Glu Val Thr Tyr Ser Thr Leu 
385                 390                 395                 400 


Asn Phe Glu Ala Gln Gln Pro Thr Gln Pro Thr Ser Ala Ser Pro Ser 
                405                 410                 415     


Leu Thr Ala Thr Glu Ile Ile Tyr Ser Glu Val Lys Lys Gln 
            420                 425                 430 


<210>  664
<211>  461
<212>  PRT
<213>  Homo sapiens

<400>  664

Met Gly His Leu Ser Ala Pro Leu His Arg Val Arg Val Pro Trp Gln 
1               5                   10                  15      


Gly Leu Leu Leu Thr Ala Ser Leu Leu Thr Phe Trp Asn Pro Pro Thr 
            20                  25                  30          


Thr Ala Gln Leu Thr Thr Glu Ser Met Pro Phe Asn Val Ala Glu Gly 
        35                  40                  45              


Lys Glu Val Leu Leu Leu Val His Asn Leu Pro Gln Gln Leu Phe Gly 
    50                  55                  60                  


Tyr Ser Trp Tyr Lys Gly Glu Arg Val Asp Gly Asn Arg Gln Ile Val 
65                  70                  75                  80  


Gly Tyr Ala Ile Gly Thr Gln Gln Ala Thr Pro Gly Pro Ala Asn Ser 
                85                  90                  95      


Gly Arg Glu Thr Ile Tyr Pro Asn Ala Ser Leu Leu Ile Gln Asn Val 
            100                 105                 110         


Thr Gln Asn Asp Thr Gly Phe Tyr Thr Leu Gln Val Ile Lys Ser Asp 
        115                 120                 125             


Leu Val Asn Glu Glu Ala Thr Gly Gln Phe His Val Tyr Pro Glu Leu 
    130                 135                 140                 


Pro Lys Pro Ser Ile Ser Ser Asn Asn Ser Asn Pro Val Glu Asp Lys 
145                 150                 155                 160 


Asp Ala Val Ala Phe Thr Cys Glu Pro Glu Thr Gln Asp Thr Thr Tyr 
                165                 170                 175     


Leu Trp Trp Ile Asn Asn Gln Ser Leu Pro Val Ser Pro Arg Leu Gln 
            180                 185                 190         


Leu Ser Asn Gly Asn Arg Thr Leu Thr Leu Leu Ser Val Thr Arg Asn 
        195                 200                 205             


Asp Thr Gly Pro Tyr Glu Cys Glu Ile Gln Asn Pro Val Ser Ala Asn 
    210                 215                 220                 


Arg Ser Asp Pro Val Thr Leu Asn Val Thr Tyr Gly Pro Asp Thr Pro 
225                 230                 235                 240 


Thr Ile Ser Pro Ser Asp Thr Tyr Tyr Arg Pro Gly Ala Asn Leu Ser 
                245                 250                 255     


Leu Ser Cys Tyr Ala Ala Ser Asn Pro Pro Ala Gln Tyr Ser Trp Leu 
            260                 265                 270         


Ile Asn Gly Thr Phe Gln Gln Ser Thr Gln Glu Leu Phe Ile Pro Asn 
        275                 280                 285             


Ile Thr Val Asn Asn Ser Gly Ser Tyr Thr Cys His Ala Asn Asn Ser 
    290                 295                 300                 


Val Thr Gly Cys Asn Arg Thr Thr Val Lys Thr Ile Ile Val Thr Glu 
305                 310                 315                 320 


Arg Gln Asn Leu Thr Met Leu Pro Arg Leu Asp Ser Asn Ser Trp Ala 
                325                 330                 335     


Gln Ala Ile Leu Pro Ser Val Ser Gln Ser Ala Glu Ile Thr Asp Asn 
            340                 345                 350         


Ala Leu Pro Gln Glu Asn Gly Leu Ser Pro Gly Ala Ile Ala Gly Ile 
        355                 360                 365             


Val Ile Gly Val Val Ala Leu Val Ala Leu Ile Ala Val Ala Leu Ala 
    370                 375                 380                 


Cys Phe Leu His Phe Gly Lys Thr Gly Arg Ala Ser Asp Gln Arg Asp 
385                 390                 395                 400 


Leu Thr Glu His Lys Pro Ser Val Ser Asn His Thr Gln Asp His Ser 
                405                 410                 415     


Asn Asp Pro Pro Asn Lys Met Asn Glu Val Thr Tyr Ser Thr Leu Asn 
            420                 425                 430         


Phe Glu Ala Gln Gln Pro Thr Gln Pro Thr Ser Ala Ser Pro Ser Leu 
        435                 440                 445             


Thr Ala Thr Glu Ile Ile Tyr Ser Glu Val Lys Lys Gln 
    450                 455                 460     


<210>  665
<211>  464
<212>  PRT
<213>  Homo sapiens

<400>  665

Met Gly His Leu Ser Ala Pro Leu His Arg Val Arg Val Pro Trp Gln 
1               5                   10                  15      


Gly Leu Leu Leu Thr Ala Ser Leu Leu Thr Phe Trp Asn Pro Pro Thr 
            20                  25                  30          


Thr Ala Gln Leu Thr Thr Glu Ser Met Pro Phe Asn Val Ala Glu Gly 
        35                  40                  45              


Lys Glu Val Leu Leu Leu Val His Asn Leu Pro Gln Gln Leu Phe Gly 
    50                  55                  60                  


Tyr Ser Trp Tyr Lys Gly Glu Arg Val Asp Gly Asn Arg Gln Ile Val 
65                  70                  75                  80  


Gly Tyr Ala Ile Gly Thr Gln Gln Ala Thr Pro Gly Pro Ala Asn Ser 
                85                  90                  95      


Gly Arg Glu Thr Ile Tyr Pro Asn Ala Ser Leu Leu Ile Gln Asn Val 
            100                 105                 110         


Thr Gln Asn Asp Thr Gly Phe Tyr Thr Leu Gln Val Ile Lys Ser Asp 
        115                 120                 125             


Leu Val Asn Glu Glu Ala Thr Gly Gln Phe His Val Tyr Pro Glu Leu 
    130                 135                 140                 


Pro Lys Pro Ser Ile Ser Ser Asn Asn Ser Asn Pro Val Glu Asp Lys 
145                 150                 155                 160 


Asp Ala Val Ala Phe Thr Cys Glu Pro Glu Thr Gln Asp Thr Thr Tyr 
                165                 170                 175     


Leu Trp Trp Ile Asn Asn Gln Ser Leu Pro Val Ser Pro Arg Leu Gln 
            180                 185                 190         


Leu Ser Asn Gly Asn Arg Thr Leu Thr Leu Leu Ser Val Thr Arg Asn 
        195                 200                 205             


Asp Thr Gly Pro Tyr Glu Cys Glu Ile Gln Asn Pro Val Ser Ala Asn 
    210                 215                 220                 


Arg Ser Asp Pro Val Thr Leu Asn Val Thr Tyr Gly Pro Asp Thr Pro 
225                 230                 235                 240 


Thr Ile Ser Pro Ser Asp Thr Tyr Tyr Arg Pro Gly Ala Asn Leu Ser 
                245                 250                 255     


Leu Ser Cys Tyr Ala Ala Ser Asn Pro Pro Ala Gln Tyr Ser Trp Leu 
            260                 265                 270         


Ile Asn Gly Thr Phe Gln Gln Ser Thr Gln Glu Leu Phe Ile Pro Asn 
        275                 280                 285             


Ile Thr Val Asn Asn Ser Gly Ser Tyr Thr Cys His Ala Asn Asn Ser 
    290                 295                 300                 


Val Thr Gly Cys Asn Arg Thr Thr Val Lys Thr Ile Ile Val Thr Glu 
305                 310                 315                 320 


Leu Ser Pro Val Val Ala Lys Pro Gln Ile Lys Ala Ser Lys Thr Thr 
                325                 330                 335     


Val Thr Gly Asp Lys Asp Ser Val Asn Leu Thr Cys Ser Thr Asn Asp 
            340                 345                 350         


Thr Gly Ile Ser Ile Arg Trp Phe Phe Lys Asn Gln Ser Leu Pro Ser 
        355                 360                 365             


Ser Glu Arg Met Lys Leu Ser Gln Gly Asn Thr Thr Leu Ser Ile Asn 
    370                 375                 380                 


Pro Val Lys Arg Glu Asp Ala Gly Thr Tyr Trp Cys Glu Val Phe Asn 
385                 390                 395                 400 


Pro Ile Ser Lys Asn Gln Ser Asp Pro Ile Met Leu Asn Val Asn Tyr 
                405                 410                 415     


Asn Ala Leu Pro Gln Glu Asn Gly Leu Ser Pro Gly Ala Ile Ala Gly 
            420                 425                 430         


Ile Val Ile Gly Val Val Ala Leu Val Ala Leu Ile Ala Val Ala Leu 
        435                 440                 445             


Ala Cys Phe Leu His Phe Gly Lys Thr Gly Ser Ser Gly Pro Leu Gln 
    450                 455                 460                 


<210>  666
<211>  368
<212>  PRT
<213>  Homo sapiens

<400>  666

Met Gly His Leu Ser Ala Pro Leu His Arg Val Arg Val Pro Trp Gln 
1               5                   10                  15      


Gly Leu Leu Leu Thr Ala Ser Leu Leu Thr Phe Trp Asn Pro Pro Thr 
            20                  25                  30          


Thr Ala Gln Leu Thr Thr Glu Ser Met Pro Phe Asn Val Ala Glu Gly 
        35                  40                  45              


Lys Glu Val Leu Leu Leu Val His Asn Leu Pro Gln Gln Leu Phe Gly 
    50                  55                  60                  


Tyr Ser Trp Tyr Lys Gly Glu Arg Val Asp Gly Asn Arg Gln Ile Val 
65                  70                  75                  80  


Gly Tyr Ala Ile Gly Thr Gln Gln Ala Thr Pro Gly Pro Ala Asn Ser 
                85                  90                  95      


Gly Arg Glu Thr Ile Tyr Pro Asn Ala Ser Leu Leu Ile Gln Asn Val 
            100                 105                 110         


Thr Gln Asn Asp Thr Gly Phe Tyr Thr Leu Gln Val Ile Lys Ser Asp 
        115                 120                 125             


Leu Val Asn Glu Glu Ala Thr Gly Gln Phe His Val Tyr Pro Glu Leu 
    130                 135                 140                 


Pro Lys Pro Ser Ile Ser Ser Asn Asn Ser Asn Pro Val Glu Asp Lys 
145                 150                 155                 160 


Asp Ala Val Ala Phe Thr Cys Glu Pro Glu Thr Gln Asp Thr Thr Tyr 
                165                 170                 175     


Leu Trp Trp Ile Asn Asn Gln Ser Leu Pro Val Ser Pro Arg Leu Gln 
            180                 185                 190         


Leu Ser Asn Gly Asn Arg Thr Leu Thr Leu Leu Ser Val Thr Arg Asn 
        195                 200                 205             


Asp Thr Gly Pro Tyr Glu Cys Glu Ile Gln Asn Pro Val Ser Ala Asn 
    210                 215                 220                 


Arg Ser Asp Pro Val Thr Leu Asn Val Thr Tyr Gly Pro Asp Thr Pro 
225                 230                 235                 240 


Thr Ile Ser Pro Ser Asp Thr Tyr Tyr Arg Pro Gly Ala Asn Leu Ser 
                245                 250                 255     


Leu Ser Cys Tyr Ala Ala Ser Asn Pro Pro Ala Gln Tyr Ser Trp Leu 
            260                 265                 270         


Ile Asn Gly Thr Phe Gln Gln Ser Thr Gln Glu Leu Phe Ile Pro Asn 
        275                 280                 285             


Ile Thr Val Asn Asn Ser Gly Ser Tyr Thr Cys His Ala Asn Asn Ser 
    290                 295                 300                 


Val Thr Gly Cys Asn Arg Thr Thr Val Lys Thr Ile Ile Val Thr Asp 
305                 310                 315                 320 


Asn Ala Leu Pro Gln Glu Asn Gly Leu Ser Pro Gly Ala Ile Ala Gly 
                325                 330                 335     


Ile Val Ile Gly Val Val Ala Leu Val Ala Leu Ile Ala Val Ala Leu 
            340                 345                 350         


Ala Cys Phe Leu His Phe Gly Lys Thr Gly Ser Ser Gly Pro Leu Gln 
        355                 360                 365             


<210>  667
<211>  94
<212>  PRT
<213>  Homo sapiens

<400>  667

Met Pro Phe Asn Val Ala Glu Gly Lys Glu Val Leu Leu Leu Val His 
1               5                   10                  15      


Asn Leu Pro Gln Gln Leu Phe Gly Tyr Ser Trp Tyr Lys Gly Glu Arg 
            20                  25                  30          


Val Asp Gly Asn Arg Gln Ile Val Gly Tyr Ala Ile Gly Thr Gln Gln 
        35                  40                  45              


Ala Thr Pro Gly Pro Ala Asn Ser Gly Arg Glu Thr Ile Tyr Pro Asn 
    50                  55                  60                  


Ala Ser Leu Leu Ile Gln Asn Val Thr Gln Asn Asp Thr Gly Phe Tyr 
65                  70                  75                  80  


Thr Leu Gln Val Ile Lys Ser Asp Leu Val Asn Glu Glu Ala 
                85                  90                  


<210>  668
<211>  399
<212>  PRT
<213>  Homo sapiens

<400>  668

Met Gly His Leu Ser Ala Pro Leu His Arg Val Arg Val Pro Trp Gln 
1               5                   10                  15      


Gly Leu Leu Leu Thr Ala Ser Leu Leu Thr Phe Trp Asn Pro Pro Thr 
            20                  25                  30          


Thr Ala Gln Leu Thr Thr Glu Ser Met Pro Phe Asn Val Ala Glu Gly 
        35                  40                  45              


Lys Glu Val Leu Leu Leu Val His Asn Leu Pro Gln Gln Leu Phe Gly 
    50                  55                  60                  


Tyr Ser Trp Tyr Lys Gly Glu Arg Val Asp Gly Asn Arg Gln Ile Val 
65                  70                  75                  80  


Gly Tyr Ala Ile Gly Thr Gln Gln Ala Thr Pro Gly Pro Ala Asn Ser 
                85                  90                  95      


Gly Arg Glu Thr Ile Tyr Pro Asn Ala Ser Leu Leu Ile Gln Asn Val 
            100                 105                 110         


Thr Gln Asn Asp Thr Gly Phe Tyr Thr Leu Gln Val Ile Lys Ser Asp 
        115                 120                 125             


Leu Val Asn Glu Glu Ala Thr Gly Gln Phe His Val Tyr Pro Glu Leu 
    130                 135                 140                 


Pro Lys Pro Ser Ile Ser Ser Asn Asn Ser Asn Pro Val Glu Asp Lys 
145                 150                 155                 160 


Asp Ala Val Ala Phe Thr Cys Glu Pro Glu Thr Gln Asp Thr Thr Tyr 
                165                 170                 175     


Leu Trp Trp Ile Asn Asn Gln Ser Leu Pro Val Ser Pro Arg Leu Gln 
            180                 185                 190         


Leu Ser Asn Gly Asn Arg Thr Leu Thr Leu Leu Ser Val Thr Arg Asn 
        195                 200                 205             


Asp Thr Gly Pro Tyr Glu Cys Glu Ile Gln Asn Pro Val Ser Ala Asn 
    210                 215                 220                 


Arg Ser Asp Pro Val Thr Leu Asn Val Thr Tyr Gly Pro Asp Thr Pro 
225                 230                 235                 240 


Thr Ile Ser Pro Ser Asp Thr Tyr Tyr Arg Pro Gly Ala Asn Leu Ser 
                245                 250                 255     


Leu Ser Cys Tyr Ala Ala Ser Asn Pro Pro Ala Gln Tyr Ser Trp Leu 
            260                 265                 270         


Ile Asn Gly Thr Phe Gln Gln Ser Thr Gln Glu Leu Phe Ile Pro Asn 
        275                 280                 285             


Ile Thr Val Asn Asn Ser Gly Ser Tyr Thr Cys His Ala Asn Asn Ser 
    290                 295                 300                 


Val Thr Gly Cys Asn Arg Thr Thr Val Lys Thr Ile Ile Val Thr Glu 
305                 310                 315                 320 


Met Ala Phe His His Val Ala Lys Ala Gly Leu Lys Leu Leu Ser Ser 
                325                 330                 335     


Ser Asn Pro Pro Ala Ser Thr Ser Gln Ser Ala Lys Ile Thr Asp Asn 
            340                 345                 350         


Ala Leu Pro Gln Glu Asn Gly Leu Ser Pro Gly Ala Ile Ala Gly Ile 
        355                 360                 365             


Val Ile Gly Val Val Ala Leu Val Ala Leu Ile Ala Val Ala Leu Ala 
    370                 375                 380                 


Cys Phe Leu His Phe Gly Lys Thr Gly Ser Ser Gly Pro Leu Gln 
385                 390                 395                 


<210>  669
<211>  99
<212>  PRT
<213>  Homo sapiens

<400>  669

Met Pro Phe Asn Val Ala Glu Gly Lys Glu Val Leu Leu Leu Val His 
1               5                   10                  15      


Asn Leu Pro Gln Gln Leu Phe Gly Tyr Ser Trp Tyr Lys Gly Glu Arg 
            20                  25                  30          


Val Asp Gly Asn Arg Gln Ile Val Gly Tyr Ala Ile Gly Thr Gln Gln 
        35                  40                  45              


Ala Thr Pro Gly Pro Ala Asn Ser Gly Arg Glu Thr Ile Tyr Pro Asn 
    50                  55                  60                  


Ala Ser Leu Leu Ile Gln Asn Val Thr Gln Asn Asp Thr Gly Phe Tyr 
65                  70                  75                  80  


Thr Leu Gln Val Ile Lys Ser Asp Leu Val Asn Glu Glu Ala Thr Gly 
                85                  90                  95      


Gln Phe His 
            


<210>  670
<211>  174
<212>  PRT
<213>  Homo sapiens

<400>  670

Met Ala Cys Leu Gly Phe Gln Arg His Lys Ala Gln Leu Asn Leu Ala 
1               5                   10                  15      


Thr Arg Thr Trp Pro Cys Thr Leu Leu Phe Phe Leu Leu Phe Ile Pro 
            20                  25                  30          


Val Phe Cys Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala 
        35                  40                  45              


Ser Ser Arg Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly 
    50                  55                  60                  


Lys Ala Thr Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln 
65                  70                  75                  80  


Val Thr Glu Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr 
                85                  90                  95      


Phe Leu Asp Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val 
            100                 105                 110         


Asn Leu Thr Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile 
        115                 120                 125             


Cys Lys Val Glu Leu Met Tyr Pro Pro Pro Tyr Tyr Leu Gly Ile Gly 
    130                 135                 140                 


Asn Gly Thr Gln Ile Tyr Val Ile Ala Lys Glu Lys Lys Pro Ser Tyr 
145                 150                 155                 160 


Asn Arg Gly Leu Cys Glu Asn Ala Pro Asn Arg Ala Arg Met 
                165                 170                 


<210>  671
<211>  223
<212>  PRT
<213>  Homo sapiens

<400>  671

Met Ala Cys Leu Gly Phe Gln Arg His Lys Ala Gln Leu Asn Leu Ala 
1               5                   10                  15      


Thr Arg Thr Trp Pro Cys Thr Leu Leu Phe Phe Leu Leu Phe Ile Pro 
            20                  25                  30          


Val Phe Cys Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala 
        35                  40                  45              


Ser Ser Arg Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly 
    50                  55                  60                  


Lys Ala Thr Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln 
65                  70                  75                  80  


Val Thr Glu Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr 
                85                  90                  95      


Phe Leu Asp Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val 
            100                 105                 110         


Asn Leu Thr Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile 
        115                 120                 125             


Cys Lys Val Glu Leu Met Tyr Pro Pro Pro Tyr Tyr Leu Gly Ile Gly 
    130                 135                 140                 


Asn Gly Thr Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser 
145                 150                 155                 160 


Asp Phe Leu Leu Trp Ile Leu Ala Ala Val Ser Ser Gly Leu Phe Phe 
                165                 170                 175     


Tyr Ser Phe Leu Leu Thr Ala Val Ser Leu Ser Lys Met Leu Lys Lys 
            180                 185                 190         


Arg Ser Pro Leu Thr Thr Gly Val Tyr Val Lys Met Pro Pro Thr Glu 
        195                 200                 205             


Pro Glu Cys Glu Lys Gln Phe Gln Pro Tyr Phe Ile Pro Ile Asn 
    210                 215                 220             


<210>  672
<211>  137
<212>  PRT
<213>  Homo sapiens

<400>  672

Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ile 
1               5                   10                  15      


Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr Glu Val 
            20                  25                  30          


Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys 
        35                  40                  45              


Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Leu Asp Asp Ser 
    50                  55                  60                  


Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr Ile Gln 
65                  70                  75                  80  


Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Leu 
                85                  90                  95      


Met Tyr Pro Pro Pro Tyr Tyr Leu Gly Ile Gly Asn Gly Thr Gln Ile 
            100                 105                 110         


Tyr Val Ile Ala Lys Glu Lys Lys Pro Ser Tyr Asn Arg Gly Leu Cys 
        115                 120                 125             


Glu Asn Ala Pro Asn Arg Ala Arg Met 
    130                 135         


<210>  673
<211>  79
<212>  PRT
<213>  Homo sapiens

<400>  673

Met Ala Cys Leu Gly Phe Gln Arg His Lys Ala Gln Leu Asn Leu Ala 
1               5                   10                  15      


Thr Arg Thr Trp Pro Cys Thr Leu Leu Phe Phe Leu Leu Phe Ile Pro 
            20                  25                  30          


Val Phe Cys Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala 
        35                  40                  45              


Ser Ser Arg Gly Ile Ala Ser Phe Val Ser Lys Glu Lys Lys Pro Ser 
    50                  55                  60                  


Tyr Asn Arg Gly Leu Cys Glu Asn Ala Pro Asn Arg Ala Arg Met 
65                  70                  75                  


<210>  674
<211>  244
<212>  PRT
<213>  Homo sapiens

<400>  674

Met Arg Trp Cys Leu Leu Leu Ile Trp Ala Gln Gly Leu Arg Gln Ala 
1               5                   10                  15      


Pro Leu Ala Ser Gly Met Met Thr Gly Thr Ile Glu Thr Thr Gly Asn 
            20                  25                  30          


Ile Ser Ala Glu Lys Gly Gly Ser Ile Ile Leu Gln Cys His Leu Ser 
        35                  40                  45              


Ser Thr Thr Ala Gln Val Thr Gln Val Asn Trp Glu Gln Gln Asp Gln 
    50                  55                  60                  


Leu Leu Ala Ile Cys Asn Ala Asp Leu Gly Trp His Ile Ser Pro Ser 
65                  70                  75                  80  


Phe Lys Asp Arg Val Ala Pro Gly Pro Gly Leu Gly Leu Thr Leu Gln 
                85                  90                  95      


Ser Leu Thr Val Asn Asp Thr Gly Glu Tyr Phe Cys Ile Tyr His Thr 
            100                 105                 110         


Tyr Pro Asp Gly Thr Tyr Thr Gly Arg Ile Phe Leu Glu Val Leu Glu 
        115                 120                 125             


Ser Ser Val Ala Glu His Gly Ala Arg Phe Gln Ile Pro Leu Leu Gly 
    130                 135                 140                 


Ala Met Ala Ala Thr Leu Val Val Ile Cys Thr Ala Val Ile Val Val 
145                 150                 155                 160 


Val Ala Leu Thr Arg Lys Lys Lys Ala Leu Arg Ile His Ser Val Glu 
                165                 170                 175     


Gly Asp Leu Arg Arg Lys Ser Ala Gly Gln Glu Glu Trp Ser Pro Ser 
            180                 185                 190         


Ala Pro Ser Pro Pro Gly Ser Cys Val Gln Ala Glu Ala Ala Pro Ala 
        195                 200                 205             


Gly Leu Cys Gly Glu Gln Arg Gly Glu Asp Cys Ala Glu Leu His Asp 
    210                 215                 220                 


Tyr Phe Asn Val Leu Ser Tyr Arg Ser Leu Gly Asn Cys Ser Phe Phe 
225                 230                 235                 240 


Thr Glu Thr Gly 
                


<210>  675
<211>  169
<212>  PRT
<213>  Homo sapiens

<400>  675

Met Met Thr Gly Thr Ile Glu Thr Thr Gly Asn Ile Ser Ala Glu Lys 
1               5                   10                  15      


Gly Gly Ser Ile Ile Leu Gln Cys His Leu Ser Ser Thr Thr Ala Gln 
            20                  25                  30          


Val Thr Gln Val Asn Trp Glu Gln Gln Asp Gln Leu Leu Ala Ile Cys 
        35                  40                  45              


Asn Ala Asp Leu Gly Trp His Ile Ser Pro Ser Phe Lys Asp Arg Val 
    50                  55                  60                  


Ala Pro Gly Pro Gly Leu Gly Leu Thr Leu Gln Ser Leu Thr Val Asn 
65                  70                  75                  80  


Asp Thr Gly Glu Tyr Phe Cys Ile Tyr His Thr Tyr Pro Asp Gly Thr 
                85                  90                  95      


Tyr Thr Gly Arg Ile Phe Leu Glu Val Leu Glu Ser Ser Val Ala Glu 
            100                 105                 110         


His Gly Ala Arg Phe Gln Ile Pro Leu Leu Gly Ala Met Ala Ala Thr 
        115                 120                 125             


Leu Val Val Ile Cys Thr Ala Val Ile Val Val Val Ala Leu Thr Arg 
    130                 135                 140                 


Lys Lys Lys Ala Leu Arg Ile His Ser Val Glu Gly Asp Leu Arg Arg 
145                 150                 155                 160 


Lys Ser Ala Gly Gln Glu Glu Trp Ser 
                165                 


<210>  676
<211>  311
<212>  PRT
<213>  Homo sapiens

<400>  676

Met Ala Phe Leu Val Ala His Pro Met Gln Phe Val Tyr Leu Leu Thr 
1               5                   10                  15      


Thr Leu Cys Val Phe Asn Met Val Phe Ala Lys Leu Gly Phe Ser Glu 
            20                  25                  30          


Thr Val Phe Ser Gln Arg Leu Ser Phe Thr Val Leu Ser Ala Val Gly 
        35                  40                  45              


Tyr Phe Gln Trp Gln Lys Arg Pro His Leu Leu Pro Val Gly Pro Leu 
    50                  55                  60                  


Gly Arg Ser Met Arg Trp Cys Leu Leu Leu Ile Trp Ala Gln Gly Leu 
65                  70                  75                  80  


Arg Gln Ala Pro Leu Ala Ser Gly Met Met Thr Gly Thr Ile Glu Thr 
                85                  90                  95      


Thr Gly Asn Ile Ser Ala Glu Lys Gly Gly Ser Ile Ile Leu Gln Cys 
            100                 105                 110         


His Leu Ser Ser Thr Thr Ala Gln Val Thr Gln Val Asn Trp Glu Gln 
        115                 120                 125             


Gln Asp Gln Leu Leu Ala Ile Cys Asn Ala Asp Leu Gly Trp His Ile 
    130                 135                 140                 


Ser Pro Ser Phe Lys Asp Arg Val Ala Pro Gly Pro Gly Leu Gly Leu 
145                 150                 155                 160 


Thr Leu Gln Ser Leu Thr Val Asn Asp Thr Gly Glu Tyr Phe Cys Ile 
                165                 170                 175     


Tyr His Thr Tyr Pro Asp Gly Thr Tyr Thr Gly Arg Ile Phe Leu Glu 
            180                 185                 190         


Val Leu Glu Ser Ser Val Ala Glu His Gly Ala Arg Phe Gln Ile Pro 
        195                 200                 205             


Leu Leu Gly Ala Met Ala Ala Thr Leu Val Val Ile Cys Thr Ala Val 
    210                 215                 220                 


Ile Val Val Val Ala Leu Thr Arg Lys Lys Lys Ala Leu Arg Ile His 
225                 230                 235                 240 


Ser Val Glu Gly Asp Leu Arg Arg Lys Ser Ala Gly Gln Glu Glu Trp 
                245                 250                 255     


Ser Pro Ser Ala Pro Ser Pro Pro Gly Ser Cys Val Gln Ala Glu Ala 
            260                 265                 270         


Ala Pro Ala Gly Leu Cys Gly Glu Gln Arg Gly Glu Asp Cys Ala Glu 
        275                 280                 285             


Leu His Asp Tyr Phe Asn Val Leu Ser Tyr Arg Ser Leu Gly Asn Cys 
    290                 295                 300                 


Ser Phe Phe Thr Glu Thr Gly 
305                 310     


<210>  677
<211>  163
<212>  PRT
<213>  Homo sapiens

<400>  677

Met Met Thr Gly Thr Ile Glu Thr Thr Gly Asn Ile Ser Ala Glu Lys 
1               5                   10                  15      


Gly Gly Ser Ile Ile Leu Gln Cys His Leu Ser Ser Thr Thr Ala Gln 
            20                  25                  30          


Val Thr Gln Val Asn Trp Glu Gln Gln Asp Gln Leu Leu Ala Ile Cys 
        35                  40                  45              


Asn Ala Asp Leu Gly Trp His Ile Ser Pro Ser Phe Lys Asp Arg Val 
    50                  55                  60                  


Ala Pro Gly Pro Gly Leu Gly Leu Thr Leu Gln Ser Leu Thr Val Asn 
65                  70                  75                  80  


Asp Thr Gly Glu Tyr Phe Cys Ile Tyr His Thr Tyr Pro Asp Gly Thr 
                85                  90                  95      


Tyr Thr Gly Arg Ile Phe Leu Glu Val Leu Glu Ser Ser Val Ala Glu 
            100                 105                 110         


His Gly Ala Arg Phe Gln Ile Pro Leu Leu Gly Ala Met Ala Ala Thr 
        115                 120                 125             


Leu Val Val Ile Cys Thr Ala Val Ile Val Val Val Ala Leu Thr Arg 
    130                 135                 140                 


Lys Lys Lys Ala Leu Arg Ile His Ser Val Glu Gly Asp Leu Arg Arg 
145                 150                 155                 160 


Lys Ser Ala 
            


<210>  678
<211>  244
<212>  PRT
<213>  Homo sapiens

<400>  678

Met Arg Trp Cys Leu Leu Leu Ile Trp Ala Gln Gly Leu Arg Gln Ala 
1               5                   10                  15      


Pro Leu Ala Ser Gly Met Met Thr Gly Thr Ile Glu Thr Thr Gly Asn 
            20                  25                  30          


Ile Ser Ala Glu Lys Gly Gly Ser Ile Ile Leu Gln Cys His Leu Ser 
        35                  40                  45              


Ser Thr Thr Ala Gln Val Thr Gln Val Asn Trp Glu Gln Gln Asp Gln 
    50                  55                  60                  


Leu Leu Ala Ile Cys Asn Ala Asp Leu Gly Trp His Ile Ser Pro Ser 
65                  70                  75                  80  


Phe Lys Asp Arg Val Ala Pro Gly Pro Gly Leu Gly Leu Thr Leu Gln 
                85                  90                  95      


Ser Leu Thr Val Asn Asp Thr Gly Glu Tyr Phe Cys Ile Tyr His Thr 
            100                 105                 110         


Tyr Pro Asp Gly Thr Tyr Thr Gly Arg Ile Phe Leu Glu Val Leu Glu 
        115                 120                 125             


Ser Ser Val Ala Glu His Gly Ala Arg Phe Gln Ile Pro Leu Leu Gly 
    130                 135                 140                 


Ala Met Ala Ala Thr Leu Val Val Ile Cys Thr Ala Val Ile Val Val 
145                 150                 155                 160 


Val Ala Leu Thr Arg Lys Lys Lys Ala Leu Arg Ile His Ser Val Glu 
                165                 170                 175     


Gly Asp Leu Arg Arg Lys Ser Ala Gly Gln Glu Glu Trp Ser Pro Ser 
            180                 185                 190         


Ala Pro Ser Pro Pro Gly Ser Cys Val Gln Ala Glu Ala Ala Pro Ala 
        195                 200                 205             


Gly Leu Cys Gly Glu Gln Arg Gly Glu Asp Cys Ala Glu Leu His Asp 
    210                 215                 220                 


Tyr Phe Asn Val Leu Ser Tyr Arg Ser Leu Gly Asn Cys Ser Phe Phe 
225                 230                 235                 240 


Thr Glu Thr Gly 
                


<210>  679
<211>  263
<212>  PRT
<213>  Homo sapiens

<400>  679

Met Asp Ser Tyr Leu Leu Met Trp Gly Leu Leu Thr Phe Ile Met Val 
1               5                   10                  15      


Pro Gly Cys Gln Ala Glu Leu Cys Asp Asp Asp Pro Pro Glu Ile Pro 
            20                  25                  30          


His Ala Thr Phe Lys Ala Met Ala Tyr Lys Glu Gly Thr Met Leu Asn 
        35                  40                  45              


Cys Glu Cys Lys Arg Gly Phe Arg Arg Ile Lys Ser Gly Ser Leu Tyr 
    50                  55                  60                  


Met Leu Cys Thr Gly Asn Ser Ser His Ser Ser Trp Asp Asn Gln Cys 
65                  70                  75                  80  


Gln Cys Thr Ser Ser Ala Thr Arg Asn Thr Thr Lys Gln Val Thr Pro 
                85                  90                  95      


Gln Pro Glu Glu Gln Lys Glu Arg Lys Thr Thr Glu Met Gln Ser Pro 
            100                 105                 110         


Met Gln Pro Val Asp Gln Ala Ser Leu Pro Gly His Cys Arg Glu Pro 
        115                 120                 125             


Pro Pro Trp Glu Asn Glu Ala Thr Glu Arg Ile Tyr His Phe Val Val 
    130                 135                 140                 


Gly Gln Met Val Tyr Tyr Gln Cys Val Gln Gly Tyr Arg Ala Leu His 
145                 150                 155                 160 


Arg Gly Pro Ala Glu Ser Val Cys Lys Met Thr His Gly Lys Thr Arg 
                165                 170                 175     


Trp Thr Gln Pro Gln Leu Ile Cys Thr Gly Glu Glu Lys Pro Gln Ala 
            180                 185                 190         


Ser Pro Glu Gly Arg Pro Glu Ser Glu Thr Ser Cys Leu Val Thr Thr 
        195                 200                 205             


Thr Asp Phe Gln Ile Gln Thr Glu Met Ala Ala Thr Met Glu Thr Ser 
    210                 215                 220                 


Ile Phe Thr Thr Glu Tyr Gln Val Ala Val Ala Gly Cys Val Phe Leu 
225                 230                 235                 240 


Leu Ile Ser Val Leu Leu Leu Ser Gly Leu Thr Trp Gln Arg Arg Gln 
                245                 250                 255     


Arg Lys Ser Arg Arg Thr Ile 
            260             


<210>  680
<211>  200
<212>  PRT
<213>  Homo sapiens

<400>  680

Met Asp Ser Tyr Leu Leu Met Trp Gly Leu Leu Thr Phe Ile Met Val 
1               5                   10                  15      


Pro Gly Cys Gln Ala Glu Leu Cys Asp Asp Asp Pro Pro Glu Ile Pro 
            20                  25                  30          


His Ala Thr Phe Lys Ala Met Ala Tyr Lys Glu Gly Thr Met Leu Asn 
        35                  40                  45              


Cys Glu Cys Lys Arg Gly Phe Arg Arg Ile Lys Ser Gly Ser Leu Tyr 
    50                  55                  60                  


Met Leu Cys Thr Gly Asn Ser Ser His Ser Ser Trp Asp Asn Gln Cys 
65                  70                  75                  80  


Gln Cys Thr Ser Ser Ala Thr Arg Asn Thr Thr Lys Gln Val Thr Pro 
                85                  90                  95      


Gln Pro Glu Glu Gln Lys Glu Arg Lys Thr Thr Glu Met Gln Ser Pro 
            100                 105                 110         


Met Gln Pro Val Asp Gln Ala Ser Leu Pro Gly Glu Glu Lys Pro Gln 
        115                 120                 125             


Ala Ser Pro Glu Gly Arg Pro Glu Ser Glu Thr Ser Cys Leu Val Thr 
    130                 135                 140                 


Thr Thr Asp Phe Gln Ile Gln Thr Glu Met Ala Ala Thr Met Glu Thr 
145                 150                 155                 160 


Ser Ile Phe Thr Thr Glu Tyr Gln Val Ala Val Ala Gly Cys Val Phe 
                165                 170                 175     


Leu Leu Ile Ser Val Leu Leu Leu Ser Gly Leu Thr Trp Gln Arg Arg 
            180                 185                 190         


Gln Arg Lys Ser Arg Arg Thr Ile 
        195                 200 


<210>  681
<211>  272
<212>  PRT
<213>  Homo sapiens

<400>  681

Met Asp Ser Tyr Leu Leu Met Trp Gly Leu Leu Thr Phe Ile Met Val 
1               5                   10                  15      


Pro Gly Cys Gln Ala Glu Leu Cys Asp Asp Asp Pro Pro Glu Ile Pro 
            20                  25                  30          


His Ala Thr Phe Lys Ala Met Ala Tyr Lys Glu Gly Thr Met Leu Asn 
        35                  40                  45              


Cys Glu Cys Lys Arg Gly Phe Arg Arg Ile Lys Ser Gly Ser Leu Tyr 
    50                  55                  60                  


Met Leu Cys Thr Gly Asn Ser Ser His Ser Ser Trp Asp Asn Gln Cys 
65                  70                  75                  80  


Gln Cys Thr Ser Ser Ala Thr Arg Asn Thr Thr Lys Gln Val Thr Pro 
                85                  90                  95      


Gln Pro Glu Glu Gln Lys Glu Arg Lys Thr Thr Glu Met Gln Ser Pro 
            100                 105                 110         


Met Gln Pro Val Asp Gln Ala Ser Leu Pro Gly His Cys Arg Glu Pro 
        115                 120                 125             


Pro Pro Trp Glu Asn Glu Ala Thr Glu Arg Ile Tyr His Phe Val Val 
    130                 135                 140                 


Gly Gln Met Val Tyr Tyr Gln Cys Val Gln Gly Tyr Arg Ala Leu His 
145                 150                 155                 160 


Arg Gly Pro Ala Glu Ser Val Cys Lys Met Thr His Gly Lys Thr Arg 
                165                 170                 175     


Trp Thr Gln Pro Gln Leu Ile Cys Thr Gly Glu Met Glu Thr Ser Gln 
            180                 185                 190         


Phe Pro Gly Glu Glu Lys Pro Gln Ala Ser Pro Glu Gly Arg Pro Glu 
        195                 200                 205             


Ser Glu Thr Ser Cys Leu Val Thr Thr Thr Asp Phe Gln Ile Gln Thr 
    210                 215                 220                 


Glu Met Ala Ala Thr Met Glu Thr Ser Ile Phe Thr Thr Glu Tyr Gln 
225                 230                 235                 240 


Val Ala Val Ala Gly Cys Val Phe Leu Leu Ile Ser Val Leu Leu Leu 
                245                 250                 255     


Ser Gly Leu Thr Trp Gln Arg Arg Gln Arg Lys Ser Arg Arg Thr Ile 
            260                 265                 270         


<210>  682
<211>  510
<212>  PRT
<213>  Homo sapiens

<400>  682

Met Glu Asp Thr Lys Glu Ser Asn Val Lys Thr Phe Cys Ser Lys Asn 
1               5                   10                  15      


Ile Leu Ala Ile Leu Gly Phe Ser Ser Ile Ile Ala Val Ile Ala Leu 
            20                  25                  30          


Leu Ala Val Gly Leu Thr Gln Asn Lys Ala Leu Pro Glu Asn Val Lys 
        35                  40                  45              


Tyr Gly Ile Val Leu Asp Ala Gly Ser Ser His Thr Ser Leu Tyr Ile 
    50                  55                  60                  


Tyr Lys Trp Pro Ala Glu Lys Glu Asn Asp Thr Gly Val Val His Gln 
65                  70                  75                  80  


Val Glu Glu Cys Arg Val Lys Gly Pro Gly Ile Ser Lys Phe Val Gln 
                85                  90                  95      


Lys Val Asn Glu Ile Gly Ile Tyr Leu Thr Asp Cys Met Glu Arg Ala 
            100                 105                 110         


Arg Glu Val Ile Pro Arg Ser Gln His Gln Glu Thr Pro Val Tyr Leu 
        115                 120                 125             


Gly Ala Thr Ala Gly Met Arg Leu Leu Arg Met Glu Ser Glu Glu Leu 
    130                 135                 140                 


Ala Asp Arg Val Leu Asp Val Val Glu Arg Ser Leu Ser Asn Tyr Pro 
145                 150                 155                 160 


Phe Asp Phe Gln Gly Ala Arg Ile Ile Thr Gly Gln Glu Glu Gly Ala 
                165                 170                 175     


Tyr Gly Trp Ile Thr Ile Asn Tyr Leu Leu Gly Lys Phe Ser Gln Lys 
            180                 185                 190         


Thr Arg Trp Phe Ser Ile Val Pro Tyr Glu Thr Asn Asn Gln Glu Thr 
        195                 200                 205             


Phe Gly Ala Leu Asp Leu Gly Gly Ala Ser Thr Gln Val Thr Phe Val 
    210                 215                 220                 


Pro Gln Asn Gln Thr Ile Glu Ser Pro Asp Asn Ala Leu Gln Phe Arg 
225                 230                 235                 240 


Leu Tyr Gly Lys Asp Tyr Asn Val Tyr Thr His Ser Phe Leu Cys Tyr 
                245                 250                 255     


Gly Lys Asp Gln Ala Leu Trp Gln Lys Leu Ala Lys Asp Ile Gln Val 
            260                 265                 270         


Ala Ser Asn Glu Ile Leu Arg Asp Pro Cys Phe His Pro Gly Tyr Lys 
        275                 280                 285             


Lys Val Val Asn Val Ser Asp Leu Tyr Lys Thr Pro Cys Thr Lys Arg 
    290                 295                 300                 


Phe Glu Met Thr Leu Pro Phe Gln Gln Phe Glu Ile Gln Gly Ile Gly 
305                 310                 315                 320 


Asn Tyr Gln Gln Cys His Gln Ser Ile Leu Glu Leu Phe Asn Thr Ser 
                325                 330                 335     


Tyr Cys Pro Tyr Ser Gln Cys Ala Phe Asn Gly Ile Phe Leu Pro Pro 
            340                 345                 350         


Leu Gln Gly Asp Phe Gly Ala Phe Ser Ala Phe Tyr Phe Val Met Lys 
        355                 360                 365             


Phe Leu Asn Leu Thr Ser Glu Lys Val Ser Gln Glu Lys Val Thr Glu 
    370                 375                 380                 


Met Met Lys Lys Phe Cys Ala Gln Pro Trp Glu Glu Ile Lys Thr Ser 
385                 390                 395                 400 


Tyr Ala Gly Val Lys Glu Lys Tyr Leu Ser Glu Tyr Cys Phe Ser Gly 
                405                 410                 415     


Thr Tyr Ile Leu Ser Leu Leu Leu Gln Gly Tyr His Phe Thr Ala Asp 
            420                 425                 430         


Ser Trp Glu His Ile His Phe Ile Gly Lys Ile Gln Gly Ser Asp Ala 
        435                 440                 445             


Gly Trp Thr Leu Gly Tyr Met Leu Asn Leu Thr Asn Met Ile Pro Ala 
    450                 455                 460                 


Glu Gln Pro Leu Ser Thr Pro Leu Ser His Ser Thr Tyr Val Phe Leu 
465                 470                 475                 480 


Met Val Leu Phe Ser Leu Val Leu Phe Thr Val Ala Ile Ile Gly Leu 
                485                 490                 495     


Leu Ile Phe His Lys Pro Ser Tyr Phe Trp Lys Asp Met Val 
            500                 505                 510 


<210>  683
<211>  522
<212>  PRT
<213>  Homo sapiens

<400>  683

Met Gly Arg Glu Glu Leu Phe Leu Thr Phe Ser Phe Ser Ser Gly Phe 
1               5                   10                  15      


Gln Glu Ser Asn Val Lys Thr Phe Cys Ser Lys Asn Ile Leu Ala Ile 
            20                  25                  30          


Leu Gly Phe Ser Ser Ile Ile Ala Val Ile Ala Leu Leu Ala Val Gly 
        35                  40                  45              


Leu Thr Gln Asn Lys Ala Leu Pro Glu Asn Val Lys Tyr Gly Ile Val 
    50                  55                  60                  


Leu Asp Ala Gly Ser Ser His Thr Ser Leu Tyr Ile Tyr Lys Trp Pro 
65                  70                  75                  80  


Ala Glu Lys Glu Asn Asp Thr Gly Val Val His Gln Val Glu Glu Cys 
                85                  90                  95      


Arg Val Lys Gly Pro Gly Ile Ser Lys Phe Val Gln Lys Val Asn Glu 
            100                 105                 110         


Ile Gly Ile Tyr Leu Thr Asp Cys Met Glu Arg Ala Arg Glu Val Ile 
        115                 120                 125             


Pro Arg Ser Gln His Gln Glu Thr Pro Val Tyr Leu Gly Ala Thr Ala 
    130                 135                 140                 


Gly Met Arg Leu Leu Arg Met Glu Ser Glu Glu Leu Ala Asp Arg Val 
145                 150                 155                 160 


Leu Asp Val Val Glu Arg Ser Leu Ser Asn Tyr Pro Phe Asp Phe Gln 
                165                 170                 175     


Gly Ala Arg Ile Ile Thr Gly Gln Glu Glu Gly Ala Tyr Gly Trp Ile 
            180                 185                 190         


Thr Ile Asn Tyr Leu Leu Gly Lys Phe Ser Gln Lys Thr Arg Trp Phe 
        195                 200                 205             


Ser Ile Val Pro Tyr Glu Thr Asn Asn Gln Glu Thr Phe Gly Ala Leu 
    210                 215                 220                 


Asp Leu Gly Gly Ala Ser Thr Gln Val Thr Phe Val Pro Gln Asn Gln 
225                 230                 235                 240 


Thr Ile Glu Ser Pro Asp Asn Ala Leu Gln Phe Arg Leu Tyr Gly Lys 
                245                 250                 255     


Asp Tyr Asn Val Tyr Thr His Ser Phe Leu Cys Tyr Gly Lys Asp Gln 
            260                 265                 270         


Ala Leu Trp Gln Lys Leu Ala Lys Asp Ile Gln Val Ala Ser Asn Glu 
        275                 280                 285             


Ile Leu Arg Asp Pro Cys Phe His Pro Gly Tyr Lys Lys Val Val Asn 
    290                 295                 300                 


Val Ser Asp Leu Tyr Lys Thr Pro Cys Thr Lys Arg Phe Glu Met Thr 
305                 310                 315                 320 


Leu Pro Phe Gln Gln Phe Glu Ile Gln Gly Ile Gly Asn Tyr Gln Gln 
                325                 330                 335     


Cys His Gln Ser Ile Leu Glu Leu Phe Asn Thr Ser Tyr Cys Pro Tyr 
            340                 345                 350         


Ser Gln Cys Ala Phe Asn Gly Ile Phe Leu Pro Pro Leu Gln Gly Asp 
        355                 360                 365             


Phe Gly Ala Phe Ser Ala Phe Tyr Phe Val Met Lys Phe Leu Asn Leu 
    370                 375                 380                 


Thr Ser Glu Lys Val Ser Gln Glu Lys Val Thr Glu Met Met Lys Lys 
385                 390                 395                 400 


Phe Cys Ala Gln Pro Trp Glu Glu Ile Lys Thr Ser Tyr Ala Gly Val 
                405                 410                 415     


Lys Glu Lys Tyr Leu Ser Glu Tyr Cys Phe Ser Gly Thr Tyr Ile Leu 
            420                 425                 430         


Ser Leu Leu Leu Gln Gly Tyr His Phe Thr Ala Asp Ser Trp Glu His 
        435                 440                 445             


Ile His Phe Ile Gly Lys Ile Gln Gly Ser Asp Ala Gly Trp Thr Leu 
    450                 455                 460                 


Gly Tyr Met Leu Asn Leu Thr Asn Met Ile Pro Ala Glu Gln Pro Leu 
465                 470                 475                 480 


Ser Thr Pro Leu Ser His Ser Thr Tyr Val Phe Leu Met Val Leu Phe 
                485                 490                 495     


Ser Leu Val Leu Phe Thr Val Ala Ile Ile Gly Leu Leu Ile Phe His 
            500                 505                 510         


Lys Pro Ser Tyr Phe Trp Lys Asp Met Val 
        515                 520         


<210>  684
<211>  517
<212>  PRT
<213>  Homo sapiens

<400>  684

Met Lys Gly Thr Lys Asp Leu Thr Ser Gln Gln Lys Glu Ser Asn Val 
1               5                   10                  15      


Lys Thr Phe Cys Ser Lys Asn Ile Leu Ala Ile Leu Gly Phe Ser Ser 
            20                  25                  30          


Ile Ile Ala Val Ile Ala Leu Leu Ala Val Gly Leu Thr Gln Asn Lys 
        35                  40                  45              


Ala Leu Pro Glu Asn Val Lys Tyr Gly Ile Val Leu Asp Ala Gly Ser 
    50                  55                  60                  


Ser His Thr Ser Leu Tyr Ile Tyr Lys Trp Pro Ala Glu Lys Glu Asn 
65                  70                  75                  80  


Asp Thr Gly Val Val His Gln Val Glu Glu Cys Arg Val Lys Gly Pro 
                85                  90                  95      


Gly Ile Ser Lys Phe Val Gln Lys Val Asn Glu Ile Gly Ile Tyr Leu 
            100                 105                 110         


Thr Asp Cys Met Glu Arg Ala Arg Glu Val Ile Pro Arg Ser Gln His 
        115                 120                 125             


Gln Glu Thr Pro Val Tyr Leu Gly Ala Thr Ala Gly Met Arg Leu Leu 
    130                 135                 140                 


Arg Met Glu Ser Glu Glu Leu Ala Asp Arg Val Leu Asp Val Val Glu 
145                 150                 155                 160 


Arg Ser Leu Ser Asn Tyr Pro Phe Asp Phe Gln Gly Ala Arg Ile Ile 
                165                 170                 175     


Thr Gly Gln Glu Glu Gly Ala Tyr Gly Trp Ile Thr Ile Asn Tyr Leu 
            180                 185                 190         


Leu Gly Lys Phe Ser Gln Lys Thr Arg Trp Phe Ser Ile Val Pro Tyr 
        195                 200                 205             


Glu Thr Asn Asn Gln Glu Thr Phe Gly Ala Leu Asp Leu Gly Gly Ala 
    210                 215                 220                 


Ser Thr Gln Val Thr Phe Val Pro Gln Asn Gln Thr Ile Glu Ser Pro 
225                 230                 235                 240 


Asp Asn Ala Leu Gln Phe Arg Leu Tyr Gly Lys Asp Tyr Asn Val Tyr 
                245                 250                 255     


Thr His Ser Phe Leu Cys Tyr Gly Lys Asp Gln Ala Leu Trp Gln Lys 
            260                 265                 270         


Leu Ala Lys Asp Ile Gln Val Ala Ser Asn Glu Ile Leu Arg Asp Pro 
        275                 280                 285             


Cys Phe His Pro Gly Tyr Lys Lys Val Val Asn Val Ser Asp Leu Tyr 
    290                 295                 300                 


Lys Thr Pro Cys Thr Lys Arg Phe Glu Met Thr Leu Pro Phe Gln Gln 
305                 310                 315                 320 


Phe Glu Ile Gln Gly Ile Gly Asn Tyr Gln Gln Cys His Gln Ser Ile 
                325                 330                 335     


Leu Glu Leu Phe Asn Thr Ser Tyr Cys Pro Tyr Ser Gln Cys Ala Phe 
            340                 345                 350         


Asn Gly Ile Phe Leu Pro Pro Leu Gln Gly Asp Phe Gly Ala Phe Ser 
        355                 360                 365             


Ala Phe Tyr Phe Val Met Lys Phe Leu Asn Leu Thr Ser Glu Lys Val 
    370                 375                 380                 


Ser Gln Glu Lys Val Thr Glu Met Met Lys Lys Phe Cys Ala Gln Pro 
385                 390                 395                 400 


Trp Glu Glu Ile Lys Thr Ser Tyr Ala Gly Val Lys Glu Lys Tyr Leu 
                405                 410                 415     


Ser Glu Tyr Cys Phe Ser Gly Thr Tyr Ile Leu Ser Leu Leu Leu Gln 
            420                 425                 430         


Gly Tyr His Phe Thr Ala Asp Ser Trp Glu His Ile His Phe Ile Gly 
        435                 440                 445             


Lys Ile Gln Gly Ser Asp Ala Gly Trp Thr Leu Gly Tyr Met Leu Asn 
    450                 455                 460                 


Leu Thr Asn Met Ile Pro Ala Glu Gln Pro Leu Ser Thr Pro Leu Ser 
465                 470                 475                 480 


His Ser Thr Tyr Val Phe Leu Met Val Leu Phe Ser Leu Val Leu Phe 
                485                 490                 495     


Thr Val Ala Ile Ile Gly Leu Leu Ile Phe His Lys Pro Ser Tyr Phe 
            500                 505                 510         


Trp Lys Asp Met Val 
        515         


<210>  685
<211>  63
<212>  PRT
<213>  Homo sapiens

<400>  685

Met Glu Arg Ala Arg Glu Val Ile Pro Arg Ser Gln His Gln Glu Thr 
1               5                   10                  15      


Pro Val Tyr Leu Gly Ala Thr Ala Gly Met Arg Leu Leu Arg Val Pro 
            20                  25                  30          


Gly Ser Leu Leu Ala Lys Arg Lys Val Pro Met Ala Gly Leu Leu Ser 
        35                  40                  45              


Thr Ile Cys Trp Ala Asn Ser Val Arg Lys Gln Gly Gly Ser Ala 
    50                  55                  60              


<210>  686
<211>  402
<212>  PRT
<213>  Homo sapiens

<400>  686

Met Glu Arg Ala Arg Glu Val Ile Pro Arg Ser Gln His Gln Glu Thr 
1               5                   10                  15      


Pro Val Tyr Leu Gly Ala Thr Ala Gly Met Arg Leu Leu Arg Met Glu 
            20                  25                  30          


Ser Glu Glu Leu Ala Asp Arg Val Leu Asp Val Val Glu Arg Ser Leu 
        35                  40                  45              


Ser Asn Tyr Pro Phe Asp Phe Gln Gly Ala Arg Ile Ile Thr Gly Gln 
    50                  55                  60                  


Glu Glu Gly Ala Tyr Gly Trp Ile Thr Ile Asn Tyr Leu Leu Gly Lys 
65                  70                  75                  80  


Phe Ser Gln Lys Thr Arg Trp Phe Ser Ile Val Pro Tyr Glu Thr Asn 
                85                  90                  95      


Asn Gln Glu Thr Phe Gly Ala Leu Asp Leu Gly Gly Ala Ser Thr Gln 
            100                 105                 110         


Val Thr Phe Val Pro Gln Asn Gln Thr Ile Glu Ser Pro Asp Asn Ala 
        115                 120                 125             


Leu Gln Phe Arg Leu Tyr Gly Lys Asp Tyr Asn Val Tyr Thr His Ser 
    130                 135                 140                 


Phe Leu Cys Tyr Gly Lys Asp Gln Ala Leu Trp Gln Lys Leu Ala Lys 
145                 150                 155                 160 


Asp Ile Gln Val Ala Ser Asn Glu Ile Leu Arg Asp Pro Cys Phe His 
                165                 170                 175     


Pro Gly Tyr Lys Lys Val Val Asn Val Ser Asp Leu Tyr Lys Thr Pro 
            180                 185                 190         


Cys Thr Lys Arg Phe Glu Met Thr Leu Pro Phe Gln Gln Phe Glu Ile 
        195                 200                 205             


Gln Gly Ile Gly Asn Tyr Gln Gln Cys His Gln Ser Ile Leu Glu Leu 
    210                 215                 220                 


Phe Asn Thr Ser Tyr Cys Pro Tyr Ser Gln Cys Ala Phe Asn Gly Ile 
225                 230                 235                 240 


Phe Leu Pro Pro Leu Gln Gly Asp Phe Gly Ala Phe Ser Ala Phe Tyr 
                245                 250                 255     


Phe Val Met Lys Phe Leu Asn Leu Thr Ser Glu Lys Val Ser Gln Glu 
            260                 265                 270         


Lys Val Thr Glu Met Met Lys Lys Phe Cys Ala Gln Pro Trp Glu Glu 
        275                 280                 285             


Ile Lys Thr Ser Tyr Ala Gly Val Lys Glu Lys Tyr Leu Ser Glu Tyr 
    290                 295                 300                 


Cys Phe Ser Gly Thr Tyr Ile Leu Ser Leu Leu Leu Gln Gly Tyr His 
305                 310                 315                 320 


Phe Thr Ala Asp Ser Trp Glu His Ile His Phe Ile Gly Lys Ile Gln 
                325                 330                 335     


Gly Ser Asp Ala Gly Trp Thr Leu Gly Tyr Met Leu Asn Leu Thr Asn 
            340                 345                 350         


Met Ile Pro Ala Glu Gln Pro Leu Ser Thr Pro Leu Ser His Ser Thr 
        355                 360                 365             


Tyr Val Phe Leu Met Val Leu Phe Ser Leu Val Leu Phe Thr Val Ala 
    370                 375                 380                 


Ile Ile Gly Leu Leu Ile Phe His Lys Pro Ser Tyr Phe Trp Lys Asp 
385                 390                 395                 400 


Met Val 
        


<210>  687
<211>  51
<212>  PRT
<213>  Homo sapiens

<400>  687

Met Glu Asp Thr Lys Glu Ser Asn Val Lys Thr Phe Cys Ser Lys Asn 
1               5                   10                  15      


Ile Leu Ala Ile Leu Gly Phe Ser Ser Ile Ile Ala Val Ile Ala Leu 
            20                  25                  30          


Leu Ala Val Gly Leu Thr Gln Asn Lys Ala Leu Pro Glu Asn Val Lys 
        35                  40                  45              


Asp Gly Lys 
    50      


<210>  688
<211>  199
<212>  PRT
<213>  Homo sapiens

<400>  688

Met Lys Ser Gly Leu Trp Tyr Phe Phe Leu Phe Cys Leu Arg Ile Lys 
1               5                   10                  15      


Val Leu Thr Gly Glu Ile Asn Gly Ser Ala Asn Tyr Glu Met Phe Ile 
            20                  25                  30          


Phe His Asn Gly Gly Val Gln Ile Leu Cys Lys Tyr Pro Asp Ile Val 
        35                  40                  45              


Gln Gln Phe Lys Met Gln Leu Leu Lys Gly Gly Gln Ile Leu Cys Asp 
    50                  55                  60                  


Leu Thr Lys Thr Lys Gly Ser Gly Asn Thr Val Ser Ile Lys Ser Leu 
65                  70                  75                  80  


Lys Phe Cys His Ser Gln Leu Ser Asn Asn Ser Val Ser Phe Phe Leu 
                85                  90                  95      


Tyr Asn Leu Asp His Ser His Ala Asn Tyr Tyr Phe Cys Asn Leu Ser 
            100                 105                 110         


Ile Phe Asp Pro Pro Pro Phe Lys Val Thr Leu Thr Gly Gly Tyr Leu 
        115                 120                 125             


His Ile Tyr Glu Ser Gln Leu Cys Cys Gln Leu Lys Phe Trp Leu Pro 
    130                 135                 140                 


Ile Gly Cys Ala Ala Phe Val Val Val Cys Ile Leu Gly Cys Ile Leu 
145                 150                 155                 160 


Ile Cys Trp Leu Thr Lys Lys Lys Tyr Ser Ser Ser Val His Asp Pro 
                165                 170                 175     


Asn Gly Glu Tyr Met Phe Met Arg Ala Val Asn Thr Ala Lys Lys Ser 
            180                 185                 190         


Arg Leu Thr Asp Val Thr Leu 
        195                 


<210>  689
<211>  168
<212>  PRT
<213>  Homo sapiens

<400>  689

Met Lys Ser Gly Leu Trp Tyr Phe Phe Leu Phe Cys Leu Arg Ile Lys 
1               5                   10                  15      


Val Leu Thr Gly Glu Ile Asn Gly Ser Ala Asn Tyr Glu Met Phe Ile 
            20                  25                  30          


Phe His Asn Gly Gly Val Gln Ile Leu Cys Lys Tyr Pro Asp Ile Val 
        35                  40                  45              


Gln Gln Phe Lys Met Gln Leu Leu Lys Gly Gly Gln Ile Leu Cys Asp 
    50                  55                  60                  


Leu Thr Lys Thr Lys Gly Ser Gly Asn Thr Val Ser Ile Lys Ser Leu 
65                  70                  75                  80  


Lys Phe Cys His Ser Gln Leu Ser Asn Asn Ser Val Ser Phe Phe Leu 
                85                  90                  95      


Tyr Asn Leu Asp His Ser His Ala Asn Tyr Tyr Phe Cys Asn Leu Ser 
            100                 105                 110         


Ile Phe Asp Pro Pro Pro Phe Lys Val Thr Leu Thr Gly Gly Tyr Leu 
        115                 120                 125             


His Ile Tyr Glu Ser Gln Leu Cys Cys Gln Leu Lys Phe Trp Leu Pro 
    130                 135                 140                 


Ile Gly Cys Ala Ala Phe Val Val Val Cys Ile Leu Gly Cys Ile Leu 
145                 150                 155                 160 


Ile Cys Trp Leu Thr Lys Lys Met 
                165             


<210>  690
<211>  277
<212>  PRT
<213>  Homo sapiens

<400>  690

Met Cys Val Gly Ala Arg Arg Leu Gly Arg Gly Pro Cys Ala Ala Leu 
1               5                   10                  15      


Leu Leu Leu Gly Leu Gly Leu Ser Thr Val Thr Gly Leu His Cys Val 
            20                  25                  30          


Gly Asp Thr Tyr Pro Ser Asn Asp Arg Cys Cys His Glu Cys Arg Pro 
        35                  40                  45              


Gly Asn Gly Met Val Ser Arg Cys Ser Arg Ser Gln Asn Thr Val Cys 
    50                  55                  60                  


Arg Pro Cys Gly Pro Gly Phe Tyr Asn Asp Val Val Ser Ser Lys Pro 
65                  70                  75                  80  


Cys Lys Pro Cys Thr Trp Cys Asn Leu Arg Ser Gly Ser Glu Arg Lys 
                85                  90                  95      


Gln Leu Cys Thr Ala Thr Gln Asp Thr Val Cys Arg Cys Arg Ala Gly 
            100                 105                 110         


Thr Gln Pro Leu Asp Ser Tyr Lys Pro Gly Val Asp Cys Ala Pro Cys 
        115                 120                 125             


Pro Pro Gly His Phe Ser Pro Gly Asp Asn Gln Ala Cys Lys Pro Trp 
    130                 135                 140                 


Thr Asn Cys Thr Leu Ala Gly Lys His Thr Leu Gln Pro Ala Ser Asn 
145                 150                 155                 160 


Ser Ser Asp Ala Ile Cys Glu Asp Arg Asp Pro Pro Ala Thr Gln Pro 
                165                 170                 175     


Gln Glu Thr Gln Gly Pro Pro Ala Arg Pro Ile Thr Val Gln Pro Thr 
            180                 185                 190         


Glu Ala Trp Pro Arg Thr Ser Gln Gly Pro Ser Thr Arg Pro Val Glu 
        195                 200                 205             


Val Pro Gly Gly Arg Ala Val Ala Ala Ile Leu Gly Leu Gly Leu Val 
    210                 215                 220                 


Leu Gly Leu Leu Gly Pro Leu Ala Ile Leu Leu Ala Leu Tyr Leu Leu 
225                 230                 235                 240 


Arg Arg Asp Gln Arg Leu Pro Pro Asp Ala His Lys Pro Pro Gly Gly 
                245                 250                 255     


Gly Ser Phe Arg Thr Pro Ile Gln Glu Glu Gln Ala Asp Ala His Ser 
            260                 265                 270         


Thr Leu Ala Lys Ile 
        275         


<210>  691
<211>  255
<212>  PRT
<213>  Homo sapiens

<400>  691

Met Ala Gln His Gly Ala Met Gly Ala Phe Arg Ala Leu Cys Gly Leu 
1               5                   10                  15      


Ala Leu Leu Cys Ala Leu Ser Leu Gly Gln Arg Pro Thr Gly Gly Pro 
            20                  25                  30          


Gly Cys Gly Pro Gly Arg Leu Leu Leu Gly Thr Gly Thr Asp Ala Arg 
        35                  40                  45              


Cys Cys Arg Val His Thr Thr Arg Cys Cys Arg Asp Tyr Pro Gly Glu 
    50                  55                  60                  


Glu Cys Cys Ser Glu Trp Asp Cys Met Cys Val Gln Pro Glu Phe His 
65                  70                  75                  80  


Cys Gly Asp Pro Cys Cys Thr Thr Cys Arg His His Pro Cys Pro Pro 
                85                  90                  95      


Gly Gln Gly Val Gln Ser Gln Gly Lys Phe Ser Phe Gly Phe Gln Cys 
            100                 105                 110         


Ile Asp Cys Ala Ser Gly Thr Phe Ser Gly Gly His Glu Gly His Cys 
        115                 120                 125             


Lys Pro Trp Thr Asp Cys Cys Trp Arg Cys Arg Arg Arg Pro Lys Thr 
    130                 135                 140                 


Pro Glu Ala Ala Ser Ser Pro Arg Lys Ser Gly Ala Ser Asp Arg Gln 
145                 150                 155                 160 


Arg Arg Arg Gly Gly Trp Glu Thr Cys Gly Cys Glu Pro Gly Arg Pro 
                165                 170                 175     


Pro Gly Pro Pro Thr Ala Ala Ser Pro Ser Pro Gly Ala Pro Gln Ala 
            180                 185                 190         


Ala Gly Ala Leu Arg Ser Ala Leu Gly Arg Ala Leu Leu Pro Trp Gln 
        195                 200                 205             


Gln Lys Trp Val Gln Glu Gly Gly Ser Asp Gln Arg Pro Gly Pro Cys 
    210                 215                 220                 


Ser Ser Ala Ala Ala Ala Gly Pro Cys Arg Arg Glu Arg Glu Thr Gln 
225                 230                 235                 240 


Ser Trp Pro Pro Ser Ser Leu Ala Gly Pro Asp Gly Val Gly Ser 
                245                 250                 255 


<210>  692
<211>  234
<212>  PRT
<213>  Homo sapiens

<400>  692

Met Ala Gln His Gly Ala Met Gly Ala Phe Arg Ala Leu Cys Gly Leu 
1               5                   10                  15      


Ala Leu Leu Cys Ala Leu Ser Leu Gly Gln Arg Pro Thr Gly Gly Pro 
            20                  25                  30          


Gly Cys Gly Pro Gly Arg Leu Leu Leu Gly Thr Gly Thr Asp Ala Arg 
        35                  40                  45              


Cys Cys Arg Val His Thr Thr Arg Cys Cys Arg Asp Tyr Pro Gly Glu 
    50                  55                  60                  


Glu Cys Cys Ser Glu Trp Asp Cys Met Cys Val Gln Pro Glu Phe His 
65                  70                  75                  80  


Cys Gly Asp Pro Cys Cys Thr Thr Cys Arg His His Pro Cys Pro Pro 
                85                  90                  95      


Gly Gln Gly Val Gln Ser Gln Gly Lys Phe Ser Phe Gly Phe Gln Cys 
            100                 105                 110         


Ile Asp Cys Ala Ser Gly Thr Phe Ser Gly Gly His Glu Gly His Cys 
        115                 120                 125             


Lys Pro Trp Thr Asp Cys Thr Gln Phe Gly Phe Leu Thr Val Phe Pro 
    130                 135                 140                 


Gly Asn Lys Thr His Asn Ala Val Cys Val Pro Gly Ser Pro Pro Ala 
145                 150                 155                 160 


Glu Pro Leu Gly Trp Leu Thr Val Val Leu Leu Ala Val Ala Ala Cys 
                165                 170                 175     


Val Leu Leu Leu Thr Ser Ala Gln Leu Gly Leu His Ile Trp Gln Leu 
            180                 185                 190         


Arg Lys Thr Gln Leu Leu Leu Glu Val Pro Pro Ser Thr Glu Asp Ala 
        195                 200                 205             


Arg Ser Cys Gln Phe Pro Glu Glu Glu Arg Gly Glu Arg Ser Ala Glu 
    210                 215                 220                 


Glu Lys Gly Arg Leu Gly Asp Leu Trp Val 
225                 230                 


<210>  693
<211>  241
<212>  PRT
<213>  Homo sapiens

<400>  693

Met Ala Gln His Gly Ala Met Gly Ala Phe Arg Ala Leu Cys Gly Leu 
1               5                   10                  15      


Ala Leu Leu Cys Ala Leu Ser Leu Gly Gln Arg Pro Thr Gly Gly Pro 
            20                  25                  30          


Gly Cys Gly Pro Gly Arg Leu Leu Leu Gly Thr Gly Thr Asp Ala Arg 
        35                  40                  45              


Cys Cys Arg Val His Thr Thr Arg Cys Cys Arg Asp Tyr Pro Gly Glu 
    50                  55                  60                  


Glu Cys Cys Ser Glu Trp Asp Cys Met Cys Val Gln Pro Glu Phe His 
65                  70                  75                  80  


Cys Gly Asp Pro Cys Cys Thr Thr Cys Arg His His Pro Cys Pro Pro 
                85                  90                  95      


Gly Gln Gly Val Gln Ser Gln Gly Lys Phe Ser Phe Gly Phe Gln Cys 
            100                 105                 110         


Ile Asp Cys Ala Ser Gly Thr Phe Ser Gly Gly His Glu Gly His Cys 
        115                 120                 125             


Lys Pro Trp Thr Asp Cys Thr Gln Phe Gly Phe Leu Thr Val Phe Pro 
    130                 135                 140                 


Gly Asn Lys Thr His Asn Ala Val Cys Val Pro Gly Ser Pro Pro Ala 
145                 150                 155                 160 


Glu Pro Leu Gly Trp Leu Thr Val Val Leu Leu Ala Val Ala Ala Cys 
                165                 170                 175     


Val Leu Leu Leu Thr Ser Ala Gln Leu Gly Leu His Ile Trp Gln Leu 
            180                 185                 190         


Arg Ser Gln Cys Met Trp Pro Arg Glu Thr Gln Leu Leu Leu Glu Val 
        195                 200                 205             


Pro Pro Ser Thr Glu Asp Ala Arg Ser Cys Gln Phe Pro Glu Glu Glu 
    210                 215                 220                 


Arg Gly Glu Arg Ser Ala Glu Glu Lys Gly Arg Leu Gly Asp Leu Trp 
225                 230                 235                 240 


Val 
    


<210>  694
<211>  169
<212>  PRT
<213>  Homo sapiens

<400>  694

Met Cys Val Gln Pro Glu Phe His Cys Gly Asp Pro Cys Cys Thr Thr 
1               5                   10                  15      


Cys Arg His His Pro Cys Pro Pro Gly Gln Gly Val Gln Ser Gln Gly 
            20                  25                  30          


Lys Phe Ser Phe Gly Phe Gln Cys Ile Asp Cys Ala Ser Gly Thr Phe 
        35                  40                  45              


Ser Gly Gly His Glu Gly His Cys Lys Pro Trp Thr Asp Cys Thr Gln 
    50                  55                  60                  


Phe Gly Phe Leu Thr Val Phe Pro Gly Asn Lys Thr His Asn Ala Val 
65                  70                  75                  80  


Cys Val Pro Gly Ser Pro Pro Ala Glu Pro Leu Gly Trp Leu Thr Val 
                85                  90                  95      


Val Leu Leu Ala Val Ala Ala Cys Val Leu Leu Leu Thr Ser Ala Gln 
            100                 105                 110         


Leu Gly Leu His Ile Trp Gln Leu Arg Ser Gln Cys Met Trp Pro Arg 
        115                 120                 125             


Glu Thr Gln Leu Leu Leu Glu Val Pro Pro Ser Thr Glu Asp Ala Arg 
    130                 135                 140                 


Ser Cys Gln Phe Pro Glu Glu Glu Arg Gly Glu Arg Ser Ala Glu Glu 
145                 150                 155                 160 


Lys Gly Arg Leu Gly Asp Leu Trp Val 
                165                 


<210>  695
<211>  595
<212>  PRT
<213>  Homo sapiens

<400>  695

Met Arg Val Leu Leu Ala Ala Leu Gly Leu Leu Phe Leu Gly Ala Leu 
1               5                   10                  15      


Arg Ala Phe Pro Gln Asp Arg Pro Phe Glu Asp Thr Cys His Gly Asn 
            20                  25                  30          


Pro Ser His Tyr Tyr Asp Lys Ala Val Arg Arg Cys Cys Tyr Arg Cys 
        35                  40                  45              


Pro Met Gly Leu Phe Pro Thr Gln Gln Cys Pro Gln Arg Pro Thr Asp 
    50                  55                  60                  


Cys Arg Lys Gln Cys Glu Pro Asp Tyr Tyr Leu Asp Glu Ala Asp Arg 
65                  70                  75                  80  


Cys Thr Ala Cys Val Thr Cys Ser Arg Asp Asp Leu Val Glu Lys Thr 
                85                  90                  95      


Pro Cys Ala Trp Asn Ser Ser Arg Val Cys Glu Cys Arg Pro Gly Met 
            100                 105                 110         


Phe Cys Ser Thr Ser Ala Val Asn Ser Cys Ala Arg Cys Phe Phe His 
        115                 120                 125             


Ser Val Cys Pro Ala Gly Met Ile Val Lys Phe Pro Gly Thr Ala Gln 
    130                 135                 140                 


Lys Asn Thr Val Cys Glu Pro Ala Ser Pro Gly Val Ser Pro Ala Cys 
145                 150                 155                 160 


Ala Ser Pro Glu Asn Cys Lys Glu Pro Ser Ser Gly Thr Ile Pro Gln 
                165                 170                 175     


Ala Lys Pro Thr Pro Val Ser Pro Ala Thr Ser Ser Ala Ser Thr Met 
            180                 185                 190         


Pro Val Arg Gly Gly Thr Arg Leu Ala Gln Glu Ala Ala Ser Lys Leu 
        195                 200                 205             


Thr Arg Ala Pro Asp Ser Pro Ser Ser Val Gly Arg Pro Ser Ser Asp 
    210                 215                 220                 


Pro Gly Leu Ser Pro Thr Gln Pro Cys Pro Glu Gly Ser Gly Asp Cys 
225                 230                 235                 240 


Arg Lys Gln Cys Glu Pro Asp Tyr Tyr Leu Asp Glu Ala Gly Arg Cys 
                245                 250                 255     


Thr Ala Cys Val Ser Cys Ser Arg Asp Asp Leu Val Glu Lys Thr Pro 
            260                 265                 270         


Cys Ala Trp Asn Ser Ser Arg Thr Cys Glu Cys Arg Pro Gly Met Ile 
        275                 280                 285             


Cys Ala Thr Ser Ala Thr Asn Ser Cys Ala Arg Cys Val Pro Tyr Pro 
    290                 295                 300                 


Ile Cys Ala Ala Glu Thr Val Thr Lys Pro Gln Asp Met Ala Glu Lys 
305                 310                 315                 320 


Asp Thr Thr Phe Glu Ala Pro Pro Leu Gly Thr Gln Pro Asp Cys Asn 
                325                 330                 335     


Pro Thr Pro Glu Asn Gly Glu Ala Pro Ala Ser Thr Ser Pro Thr Gln 
            340                 345                 350         


Ser Leu Leu Val Asp Ser Gln Ala Ser Lys Thr Leu Pro Ile Pro Thr 
        355                 360                 365             


Ser Ala Pro Val Ala Leu Ser Ser Thr Gly Lys Pro Val Leu Asp Ala 
    370                 375                 380                 


Gly Pro Val Leu Phe Trp Val Ile Leu Val Leu Val Val Val Val Gly 
385                 390                 395                 400 


Ser Ser Ala Phe Leu Leu Cys His Arg Arg Ala Cys Arg Lys Arg Ile 
                405                 410                 415     


Arg Gln Lys Leu His Leu Cys Tyr Pro Val Gln Thr Ser Gln Pro Lys 
            420                 425                 430         


Leu Glu Leu Val Asp Ser Arg Pro Arg Arg Ser Ser Thr Gln Leu Arg 
        435                 440                 445             


Ser Gly Ala Ser Val Thr Glu Pro Val Ala Glu Glu Arg Gly Leu Met 
    450                 455                 460                 


Ser Gln Pro Leu Met Glu Thr Cys His Ser Val Gly Ala Ala Tyr Leu 
465                 470                 475                 480 


Glu Ser Leu Pro Leu Gln Asp Ala Ser Pro Ala Gly Gly Pro Ser Ser 
                485                 490                 495     


Pro Arg Asp Leu Pro Glu Pro Arg Val Ser Thr Glu His Thr Asn Asn 
            500                 505                 510         


Lys Ile Glu Lys Ile Tyr Ile Met Lys Ala Asp Thr Val Ile Val Gly 
        515                 520                 525             


Thr Val Lys Ala Glu Leu Pro Glu Gly Arg Gly Leu Ala Gly Pro Ala 
    530                 535                 540                 


Glu Pro Glu Leu Glu Glu Glu Leu Glu Ala Asp His Thr Pro His Tyr 
545                 550                 555                 560 


Pro Glu Gln Glu Thr Glu Pro Pro Leu Gly Ser Cys Ser Asp Val Met 
                565                 570                 575     


Leu Ser Val Glu Glu Glu Gly Lys Glu Asp Pro Leu Pro Thr Ala Ala 
            580                 585                 590         


Ser Gly Lys 
        595 


<210>  696
<211>  483
<212>  PRT
<213>  Homo sapiens

<400>  696

Met Phe Cys Ser Thr Ser Ala Val Asn Ser Cys Ala Arg Cys Phe Phe 
1               5                   10                  15      


His Ser Val Cys Pro Ala Gly Met Ile Val Lys Phe Pro Gly Thr Ala 
            20                  25                  30          


Gln Lys Asn Thr Val Cys Glu Pro Ala Ser Pro Gly Val Ser Pro Ala 
        35                  40                  45              


Cys Ala Ser Pro Glu Asn Cys Lys Glu Pro Ser Ser Gly Thr Ile Pro 
    50                  55                  60                  


Gln Ala Lys Pro Thr Pro Val Ser Pro Ala Thr Ser Ser Ala Ser Thr 
65                  70                  75                  80  


Met Pro Val Arg Gly Gly Thr Arg Leu Ala Gln Glu Ala Ala Ser Lys 
                85                  90                  95      


Leu Thr Arg Ala Pro Asp Ser Pro Ser Ser Val Gly Arg Pro Ser Ser 
            100                 105                 110         


Asp Pro Gly Leu Ser Pro Thr Gln Pro Cys Pro Glu Gly Ser Gly Asp 
        115                 120                 125             


Cys Arg Lys Gln Cys Glu Pro Asp Tyr Tyr Leu Asp Glu Ala Gly Arg 
    130                 135                 140                 


Cys Thr Ala Cys Val Ser Cys Ser Arg Asp Asp Leu Val Glu Lys Thr 
145                 150                 155                 160 


Pro Cys Ala Trp Asn Ser Ser Arg Thr Cys Glu Cys Arg Pro Gly Met 
                165                 170                 175     


Ile Cys Ala Thr Ser Ala Thr Asn Ser Cys Ala Arg Cys Val Pro Tyr 
            180                 185                 190         


Pro Ile Cys Ala Ala Glu Thr Val Thr Lys Pro Gln Asp Met Ala Glu 
        195                 200                 205             


Lys Asp Thr Thr Phe Glu Ala Pro Pro Leu Gly Thr Gln Pro Asp Cys 
    210                 215                 220                 


Asn Pro Thr Pro Glu Asn Gly Glu Ala Pro Ala Ser Thr Ser Pro Thr 
225                 230                 235                 240 


Gln Ser Leu Leu Val Asp Ser Gln Ala Ser Lys Thr Leu Pro Ile Pro 
                245                 250                 255     


Thr Ser Ala Pro Val Ala Leu Ser Ser Thr Gly Lys Pro Val Leu Asp 
            260                 265                 270         


Ala Gly Pro Val Leu Phe Trp Val Ile Leu Val Leu Val Val Val Val 
        275                 280                 285             


Gly Ser Ser Ala Phe Leu Leu Cys His Arg Arg Ala Cys Arg Lys Arg 
    290                 295                 300                 


Ile Arg Gln Lys Leu His Leu Cys Tyr Pro Val Gln Thr Ser Gln Pro 
305                 310                 315                 320 


Lys Leu Glu Leu Val Asp Ser Arg Pro Arg Arg Ser Ser Thr Leu Arg 
                325                 330                 335     


Ser Gly Ala Ser Val Thr Glu Pro Val Ala Glu Glu Arg Gly Leu Met 
            340                 345                 350         


Ser Gln Pro Leu Met Glu Thr Cys His Ser Val Gly Ala Ala Tyr Leu 
        355                 360                 365             


Glu Ser Leu Pro Leu Gln Asp Ala Ser Pro Ala Gly Gly Pro Ser Ser 
    370                 375                 380                 


Pro Arg Asp Leu Pro Glu Pro Arg Val Ser Thr Glu His Thr Asn Asn 
385                 390                 395                 400 


Lys Ile Glu Lys Ile Tyr Ile Met Lys Ala Asp Thr Val Ile Val Gly 
                405                 410                 415     


Thr Val Lys Ala Glu Leu Pro Glu Gly Arg Gly Leu Ala Gly Pro Ala 
            420                 425                 430         


Glu Pro Glu Leu Glu Glu Glu Leu Glu Ala Asp His Thr Pro His Tyr 
        435                 440                 445             


Pro Glu Gln Glu Thr Glu Pro Pro Leu Gly Ser Cys Ser Asp Val Met 
    450                 455                 460                 


Leu Ser Val Glu Glu Glu Gly Lys Glu Asp Pro Leu Pro Thr Ala Ala 
465                 470                 475                 480 


Ser Gly Lys 
            


<210>  697
<211>  55
<212>  PRT
<213>  Homo sapiens

<400>  697

Met Arg Val Leu Leu Ala Ala Leu Gly Leu Leu Phe Leu Gly Ala Leu 
1               5                   10                  15      


Arg Ala Phe Pro Gln Gly Cys Ser Arg His Ser Ser Ala His Arg Gly 
            20                  25                  30          


Leu Leu Thr Ala Gly Ser Ser Val Ser Leu Thr Thr Thr Trp Met Arg 
        35                  40                  45              


Pro Thr Ala Val Gln Pro Ala 
    50                  55  


<210>  698
<211>  176
<212>  PRT
<213>  Homo sapiens

<400>  698

Met Arg Ile Phe Ala Val Phe Ile Phe Met Thr Tyr Trp His Leu Leu 
1               5                   10                  15      


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
            20                  25                  30          


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
        35                  40                  45              


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
    50                  55                  60                  


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
65                  70                  75                  80  


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
                85                  90                  95      


Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
            100                 105                 110         


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr His Leu Val 
        115                 120                 125             


Ile Leu Gly Ala Ile Leu Leu Cys Leu Gly Val Ala Leu Thr Phe Ile 
    130                 135                 140                 


Phe Arg Leu Arg Lys Gly Arg Met Met Asp Val Lys Lys Cys Gly Ile 
145                 150                 155                 160 


Gln Asp Thr Asn Ser Lys Lys Gln Ser Asp Thr His Leu Glu Glu Thr 
                165                 170                 175     


<210>  699
<211>  290
<212>  PRT
<213>  Homo sapiens

<400>  699

Met Arg Ile Phe Ala Val Phe Ile Phe Met Thr Tyr Trp His Leu Leu 
1               5                   10                  15      


Asn Ala Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr 
            20                  25                  30          


Gly Ser Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu 
        35                  40                  45              


Asp Leu Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile 
    50                  55                  60                  


Ile Gln Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser 
65                  70                  75                  80  


Tyr Arg Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn 
                85                  90                  95      


Ala Ala Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr 
            100                 105                 110         


Arg Cys Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val 
        115                 120                 125             


Lys Val Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val 
    130                 135                 140                 


Asp Pro Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr 
145                 150                 155                 160 


Pro Lys Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser 
                165                 170                 175     


Gly Lys Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn 
            180                 185                 190         


Val Thr Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr 
        195                 200                 205             


Cys Thr Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu 
    210                 215                 220                 


Val Ile Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr His 
225                 230                 235                 240 


Leu Val Ile Leu Gly Ala Ile Leu Leu Cys Leu Gly Val Ala Leu Thr 
                245                 250                 255     


Phe Ile Phe Arg Leu Arg Lys Gly Arg Met Met Asp Val Lys Lys Cys 
            260                 265                 270         


Gly Ile Gln Asp Thr Asn Ser Lys Lys Gln Ser Asp Thr His Leu Glu 
        275                 280                 285             


Glu Thr 
    290 


<210>  700
<211>  551
<212>  PRT
<213>  Homo sapiens

<400>  700

Met Ala Ala Pro Ala Leu Ser Trp Arg Leu Pro Leu Leu Ile Leu Leu 
1               5                   10                  15      


Leu Pro Leu Ala Thr Ser Trp Ala Ser Ala Ala Val Asn Gly Thr Ser 
            20                  25                  30          


Gln Phe Thr Cys Phe Tyr Asn Ser Arg Ala Asn Ile Ser Cys Val Trp 
        35                  40                  45              


Ser Gln Asp Gly Ala Leu Gln Asp Thr Ser Cys Gln Val His Ala Trp 
    50                  55                  60                  


Pro Asp Arg Arg Arg Trp Asn Gln Thr Cys Glu Leu Leu Pro Val Ser 
65                  70                  75                  80  


Gln Ala Ser Trp Ala Cys Asn Leu Ile Leu Gly Ala Pro Asp Ser Gln 
                85                  90                  95      


Lys Leu Thr Thr Val Asp Ile Val Thr Leu Arg Val Leu Cys Arg Glu 
            100                 105                 110         


Gly Val Arg Trp Arg Val Met Ala Ile Gln Asp Phe Lys Pro Phe Glu 
        115                 120                 125             


Asn Leu Arg Leu Met Ala Pro Ile Ser Leu Gln Val Val His Val Glu 
    130                 135                 140                 


Thr His Arg Cys Asn Ile Ser Trp Glu Ile Ser Gln Ala Ser His Tyr 
145                 150                 155                 160 


Phe Glu Arg His Leu Glu Phe Glu Ala Arg Thr Leu Ser Pro Gly His 
                165                 170                 175     


Thr Trp Glu Glu Ala Pro Leu Leu Thr Leu Lys Gln Lys Gln Glu Trp 
            180                 185                 190         


Ile Cys Leu Glu Thr Leu Thr Pro Asp Thr Gln Tyr Glu Phe Gln Val 
        195                 200                 205             


Arg Val Lys Pro Leu Gln Gly Glu Phe Thr Thr Trp Ser Pro Trp Ser 
    210                 215                 220                 


Gln Pro Leu Ala Phe Arg Thr Lys Pro Ala Ala Leu Gly Lys Asp Thr 
225                 230                 235                 240 


Ile Pro Trp Leu Gly His Leu Leu Val Gly Leu Ser Gly Ala Phe Gly 
                245                 250                 255     


Phe Ile Ile Leu Val Tyr Leu Leu Ile Asn Cys Arg Asn Thr Gly Pro 
            260                 265                 270         


Trp Leu Lys Lys Val Leu Lys Cys Asn Thr Pro Asp Pro Ser Lys Phe 
        275                 280                 285             


Phe Ser Gln Leu Ser Ser Glu His Gly Gly Asp Val Gln Lys Trp Leu 
    290                 295                 300                 


Ser Ser Pro Phe Pro Ser Ser Ser Phe Ser Pro Gly Gly Leu Ala Pro 
305                 310                 315                 320 


Glu Ile Ser Pro Leu Glu Val Leu Glu Arg Asp Lys Val Thr Gln Leu 
                325                 330                 335     


Leu Leu Gln Gln Asp Lys Val Pro Glu Pro Ala Ser Leu Ser Ser Asn 
            340                 345                 350         


His Ser Leu Thr Ser Cys Phe Thr Asn Gln Gly Tyr Phe Phe Phe His 
        355                 360                 365             


Leu Pro Asp Ala Leu Glu Ile Glu Ala Cys Gln Val Tyr Phe Thr Tyr 
    370                 375                 380                 


Asp Pro Tyr Ser Glu Glu Asp Pro Asp Glu Gly Val Ala Gly Ala Pro 
385                 390                 395                 400 


Thr Gly Ser Ser Pro Gln Pro Leu Gln Pro Leu Ser Gly Glu Asp Asp 
                405                 410                 415     


Ala Tyr Cys Thr Phe Pro Ser Arg Asp Asp Leu Leu Leu Phe Ser Pro 
            420                 425                 430         


Ser Leu Leu Gly Gly Pro Ser Pro Pro Ser Thr Ala Pro Gly Gly Ser 
        435                 440                 445             


Gly Ala Gly Glu Glu Arg Met Pro Pro Ser Leu Gln Glu Arg Val Pro 
    450                 455                 460                 


Arg Asp Trp Asp Pro Gln Pro Leu Gly Pro Pro Thr Pro Gly Val Pro 
465                 470                 475                 480 


Asp Leu Val Asp Phe Gln Pro Pro Pro Glu Leu Val Leu Arg Glu Ala 
                485                 490                 495     


Gly Glu Glu Val Pro Asp Ala Gly Pro Arg Glu Gly Val Ser Phe Pro 
            500                 505                 510         


Trp Ser Arg Pro Pro Gly Gln Gly Glu Phe Arg Ala Leu Asn Ala Arg 
        515                 520                 525             


Leu Pro Leu Asn Thr Asp Ala Tyr Leu Ser Leu Gln Glu Leu Gln Gly 
    530                 535                 540                 


Gln Asp Pro Thr His Leu Val 
545                 550     


<210>  701
<211>  146
<212>  PRT
<213>  Homo sapiens

<400>  701

Met Ala Ala Pro Ala Leu Ser Trp Arg Leu Pro Leu Leu Ile Leu Leu 
1               5                   10                  15      


Leu Pro Leu Ala Thr Ser Trp Ala Ser Ala Ala Val Asn Gly Thr Ser 
            20                  25                  30          


Gln Phe Thr Cys Phe Tyr Asn Ser Arg Ala Asn Ile Ser Cys Val Trp 
        35                  40                  45              


Ser Gln Asp Gly Ala Leu Gln Asp Thr Ser Cys Gln Val His Ala Trp 
    50                  55                  60                  


Pro Asp Arg Arg Arg Trp Asn Gln Thr Cys Glu Leu Leu Pro Val Ser 
65                  70                  75                  80  


Gln Ala Ser Trp Ala Cys Asn Leu Ile Leu Gly Ala Pro Asp Ser Gln 
                85                  90                  95      


Lys Leu Thr Thr Val Asp Ile Val Thr Leu Arg Val Leu Cys Arg Glu 
            100                 105                 110         


Gly Val Arg Trp Arg Val Met Ala Ile Gln Asp Phe Lys Pro Phe Glu 
        115                 120                 125             


Asn Leu Arg Leu Met Ala Pro Ile Ser Leu Gln Val Val His Val Glu 
    130                 135                 140                 


Thr His 
145     


<210>  702
<211>  88
<212>  PRT
<213>  Homo sapiens

<400>  702

Met Ala Ala Pro Ala Leu Ser Trp Arg Leu Pro Leu Leu Ile Leu Leu 
1               5                   10                  15      


Leu Pro Leu Ala Thr Ser Trp Ala Ser Ala Ala Val Asn Gly Thr Ser 
            20                  25                  30          


Gln Phe Thr Cys Phe Tyr Asn Ser Arg Ala Asn Ile Ser Cys Val Trp 
        35                  40                  45              


Ser Gln Asp Gly Ala Leu Gln Asp Thr Ser Cys Gln Val His Ala Trp 
    50                  55                  60                  


Pro Asp Arg Arg Arg Trp Asn Gln Thr Cys Glu Leu Leu Pro Val Ser 
65                  70                  75                  80  


Gln Ala Ser Trp Ala Cys Asn Leu 
                85              


<210>  703
<211>  188
<212>  PRT
<213>  Homo sapiens

<400>  703

Met Ala Ala Pro Ala Leu Ser Trp Arg Leu Pro Leu Leu Ile Leu Leu 
1               5                   10                  15      


Leu Pro Leu Ala Thr Ser Trp Ala Ser Ala Ala Val Asn Gly Thr Ser 
            20                  25                  30          


Gln Phe Thr Cys Phe Tyr Asn Ser Arg Ala Asn Ile Ser Cys Val Trp 
        35                  40                  45              


Ser Gln Asp Gly Ala Leu Gln Asp Thr Ser Cys Gln Val His Ala Trp 
    50                  55                  60                  


Pro Asp Arg Arg Arg Trp Asn Gln Thr Cys Glu Leu Leu Pro Val Ser 
65                  70                  75                  80  


Gln Ala Ser Trp Ala Cys Asn Leu Ile Leu Gly Ala Pro Asp Ser Gln 
                85                  90                  95      


Lys Leu Thr Thr Val Asp Ile Val Thr Leu Arg Val Leu Cys Arg Glu 
            100                 105                 110         


Gly Val Arg Trp Arg Val Met Ala Ile Gln Asp Phe Lys Pro Phe Glu 
        115                 120                 125             


Asn Leu Arg Leu Met Ala Pro Ile Ser Leu Gln Val Val His Val Glu 
    130                 135                 140                 


Thr His Arg Cys Asn Ile Ser Trp Glu Ile Ser Gln Ala Ser His Tyr 
145                 150                 155                 160 


Phe Glu Arg His Leu Glu Phe Glu Ala Arg Thr Leu Ser Pro Gly His 
                165                 170                 175     


Thr Trp Glu Glu Ala Pro Leu Leu Thr Leu Lys Gln 
            180                 185             


<210>  704
<211>  255
<212>  PRT
<213>  Homo sapiens

<400>  704

Met Gly Asn Ser Cys Tyr Asn Ile Val Ala Thr Leu Leu Leu Val Leu 
1               5                   10                  15      


Asn Phe Glu Arg Thr Arg Ser Leu Gln Asp Pro Cys Ser Asn Cys Pro 
            20                  25                  30          


Ala Gly Thr Phe Cys Asp Asn Asn Arg Asn Gln Ile Cys Ser Pro Cys 
        35                  40                  45              


Pro Pro Asn Ser Phe Ser Ser Ala Gly Gly Gln Arg Thr Cys Asp Ile 
    50                  55                  60                  


Cys Arg Gln Cys Lys Gly Val Phe Arg Thr Arg Lys Glu Cys Ser Ser 
65                  70                  75                  80  


Thr Ser Asn Ala Glu Cys Asp Cys Thr Pro Gly Phe His Cys Leu Gly 
                85                  90                  95      


Ala Gly Cys Ser Met Cys Glu Gln Asp Cys Lys Gln Gly Gln Glu Leu 
            100                 105                 110         


Thr Lys Lys Gly Cys Lys Asp Cys Cys Phe Gly Thr Phe Asn Asp Gln 
        115                 120                 125             


Lys Arg Gly Ile Cys Arg Pro Trp Thr Asn Cys Ser Leu Asp Gly Lys 
    130                 135                 140                 


Ser Val Leu Val Asn Gly Thr Lys Glu Arg Asp Val Val Cys Gly Pro 
145                 150                 155                 160 


Ser Pro Ala Asp Leu Ser Pro Gly Ala Ser Ser Val Thr Pro Pro Ala 
                165                 170                 175     


Pro Ala Arg Glu Pro Gly His Ser Pro Gln Ile Ile Ser Phe Phe Leu 
            180                 185                 190         


Ala Leu Thr Ser Thr Ala Leu Leu Phe Leu Leu Phe Phe Leu Thr Leu 
        195                 200                 205             


Arg Phe Ser Val Val Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe 
    210                 215                 220                 


Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly 
225                 230                 235                 240 


Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
                245                 250                 255 


<210>  705
<211>  87
<212>  PRT
<213>  Homo sapiens

<400>  705

Glu Arg Asp Val Val Cys Gly Pro Ser Pro Ala Asp Leu Ser Pro Gly 
1               5                   10                  15      


Ala Ser Ser Val Thr Pro Pro Ala Pro Ala Arg Glu Pro Gly His Ser 
            20                  25                  30          


Pro Gln Ile Ile Ser Phe Phe Leu Ala Leu Thr Ser Thr Ala Leu Leu 
        35                  40                  45              


Phe Leu Leu Phe Phe Leu Thr Leu Arg Phe Ser Val Val Lys Arg Gly 
    50                  55                  60                  


Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln His Gly Ser Ser Gly Asp 
65                  70                  75                  80  


Thr Phe Thr Ile Leu Glu Ser 
                85          


<210>  706
<211>  255
<212>  PRT
<213>  Homo sapiens

<400>  706

Met Gly Asn Ser Cys Tyr Asn Ile Val Ala Thr Leu Leu Leu Val Leu 
1               5                   10                  15      


Asn Phe Glu Arg Thr Arg Ser Leu Gln Asp Pro Cys Ser Asn Cys Pro 
            20                  25                  30          


Ala Gly Thr Phe Cys Asp Asn Asn Arg Asn Gln Ile Cys Ser Pro Cys 
        35                  40                  45              


Pro Pro Asn Ser Phe Ser Ser Ala Gly Gly Gln Arg Thr Cys Asp Ile 
    50                  55                  60                  


Cys Arg Gln Cys Lys Gly Val Phe Arg Thr Arg Lys Glu Cys Ser Ser 
65                  70                  75                  80  


Thr Ser Asn Ala Glu Cys Asp Cys Thr Pro Gly Phe His Cys Leu Gly 
                85                  90                  95      


Ala Gly Cys Ser Met Cys Glu Gln Asp Cys Lys Gln Gly Gln Glu Leu 
            100                 105                 110         


Thr Lys Lys Gly Cys Lys Asp Cys Cys Phe Gly Thr Phe Asn Asp Gln 
        115                 120                 125             


Lys Arg Gly Ile Cys Arg Pro Trp Thr Asn Cys Ser Leu Asp Gly Lys 
    130                 135                 140                 


Ser Val Leu Val Asn Gly Thr Lys Glu Arg Asp Val Val Cys Gly Pro 
145                 150                 155                 160 


Ser Pro Ala Asp Leu Ser Pro Gly Ala Ser Ser Val Thr Pro Pro Ala 
                165                 170                 175     


Pro Ala Arg Glu Pro Gly His Ser Pro Gln Ile Ile Ser Phe Phe Leu 
            180                 185                 190         


Ala Leu Thr Ser Thr Ala Leu Leu Phe Leu Leu Phe Phe Leu Thr Leu 
        195                 200                 205             


Arg Phe Ser Val Val Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe 
    210                 215                 220                 


Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly 
225                 230                 235                 240 


Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
                245                 250                 255 


<210>  707
<211>  92
<212>  PRT
<213>  Homo sapiens

<400>  707

Met His Cys Thr Leu Thr Met Glu Thr Glu Ala Ile Asp Gly Tyr Ile 
1               5                   10                  15      


Thr Cys Asp Asn Glu Leu Ser Pro Glu Arg Glu His Ser Asn Met Ala 
            20                  25                  30          


Ile Asp Leu Thr Ser Ser Thr Pro Asn Gly Gln His Ala Ser Pro Ser 
        35                  40                  45              


His Met Thr Ser Ser Lys Ser Ser Phe Tyr Asp Phe Phe Leu Cys Val 
    50                  55                  60                  


Cys Val Ser Pro Ala Thr Asp Phe Asn Leu Leu Gly Leu Trp Gly Pro 
65                  70                  75                  80  


Leu Thr Leu Trp Tyr Ser Tyr Cys Tyr Arg Phe Cys 
                85                  90          


<210>  708
<211>  660
<212>  DNA
<213>  Homo sapiens

<400>  708
atgcctcggg gacgaaagag tcggcgccgc cgtaatgcga gagccgcaga agagaaccgc       60

aacaatcgca aaatccaggc ctcagaggcc tccgagaccc ctatggccgc ctctgtggta      120

gcgagcaccc ccgaagacga cctgagcggc cccgaggaag acccgagcac tccagaggag      180

gcctctacca cccctgaaga agcctcgagc actgcccaag cacaaaagcc ttcagtgccc      240

cggagcaatt ttcagggcac caagaaaagt ctcctgatgt ctatattagc gctcatcttc      300

atcatgggca acagcgccaa ggaagctctg gtctggaaag tgctggggaa gttaggaatg      360

cagcctggac gtcagcacag catctttgga gatccgaaga agatcgtcac agaagagttt      420

gtgcgcagag ggtacctgat ttataaaccg gtgccccgta gcagtccggt ggagtatgag      480

ttcttctggg ggccccgagc acacgtggaa tcgagcaaac tgaaagtcat gcattttgtg      540

gcaagggttc gtaaccgatg ctctaaagac tggccttgta attatgactg ggattcggac      600

gatgatgcag aggttgaggc tatcctcaat tcaggtgcta ggggttattc cgccccttaa      660


<210>  709
<211>  219
<212>  PRT
<213>  Homo sapiens

<400>  709

Met Pro Arg Gly Arg Lys Ser Arg Arg Arg Arg Asn Ala Arg Ala Ala 
1               5                   10                  15      


Glu Glu Asn Arg Asn Asn Arg Lys Ile Gln Ala Ser Glu Ala Ser Glu 
            20                  25                  30          


Thr Pro Met Ala Ala Ser Val Val Ala Ser Thr Pro Glu Asp Asp Leu 
        35                  40                  45              


Ser Gly Pro Glu Glu Asp Pro Ser Thr Pro Glu Glu Ala Ser Thr Thr 
    50                  55                  60                  


Pro Glu Glu Ala Ser Ser Thr Ala Gln Ala Gln Lys Pro Ser Val Pro 
65                  70                  75                  80  


Arg Ser Asn Phe Gln Gly Thr Lys Lys Ser Leu Leu Met Ser Ile Leu 
                85                  90                  95      


Ala Leu Ile Phe Ile Met Gly Asn Ser Ala Lys Glu Ala Leu Val Trp 
            100                 105                 110         


Lys Val Leu Gly Lys Leu Gly Met Gln Pro Gly Arg Gln His Ser Ile 
        115                 120                 125             


Phe Gly Asp Pro Lys Lys Ile Val Thr Glu Glu Phe Val Arg Arg Gly 
    130                 135                 140                 


Tyr Leu Ile Tyr Lys Pro Val Pro Arg Ser Ser Pro Val Glu Tyr Glu 
145                 150                 155                 160 


Phe Phe Trp Gly Pro Arg Ala His Val Glu Ser Ser Lys Leu Lys Val 
                165                 170                 175     


Met His Phe Val Ala Arg Val Arg Asn Arg Cys Ser Lys Asp Trp Pro 
            180                 185                 190         


Cys Asn Tyr Asp Trp Asp Ser Asp Asp Asp Ala Glu Val Glu Ala Ile 
        195                 200                 205             


Leu Asn Ser Gly Ala Arg Gly Tyr Ser Ala Pro 
    210                 215                 


<210>  710
<211>  64
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Adapter sequence


<220>
<221>  misc_feature
<222>  (35)..(40)
<223>  n is a, c, g, or t

<400>  710
agatcggaag agcacacgtc tgaactccag tcacnnnnnn atctcgtatg ccgtcttctg       60

cttg                                                                    64


<210>  711
<211>  58
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Adapter sequence

<400>  711
agatcggaag agcgtcgtgt agggaaagag tgtagatctc ggtggtcgcc gtatcatt         58


<210>  712
<211>  116
<212>  PRT
<213>  Homo sapiens

<400>  712

Met Leu Arg Leu Gln Met Thr Asp Gly His Ile Ser Cys Thr Ala Val 
1               5                   10                  15      


Glu Phe Ser Tyr Met Ser Lys Ile Ser Leu Asn Thr Pro Pro Gly Thr 
            20                  25                  30          


Lys Val Lys Leu Ser Gly Ile Val Asp Ile Lys Asn Gly Phe Leu Leu 
        35                  40                  45              


Leu Asn Asp Ser Asn Thr Thr Val Leu Gly Gly Glu Val Glu His Leu 
    50                  55                  60                  


Ile Glu Lys Trp Glu Leu Gln Arg Ser Leu Ser Lys His Asn Arg Ser 
65                  70                  75                  80  


Asn Ile Gly Thr Glu Gly Gly Pro Pro Pro Phe Val Pro Phe Gly Gln 
                85                  90                  95      


Phe Gly Arg Arg Asn Ser Gln Asp Lys Arg Lys Cys Glu Val Leu Trp 
            100                 105                 110         


Cys Asp Pro Cys 
        115     


<210>  713
<211>  651
<212>  PRT
<213>  Homo sapiens

<400>  713

Met Leu Arg Leu Gln Met Thr Asp Gly His Ile Ser Cys Thr Ala Val 
1               5                   10                  15      


Glu Phe Ser Tyr Met Ser Lys Ile Ser Leu Asn Thr Pro Pro Gly Thr 
            20                  25                  30          


Lys Val Lys Leu Ser Gly Ile Val Asp Ile Lys Asn Gly Phe Leu Leu 
        35                  40                  45              


Leu Asn Asp Ser Asn Thr Thr Val Leu Gly Gly Glu Val Glu His Leu 
    50                  55                  60                  


Ile Glu Lys Trp Glu Leu Gln Arg Ser Leu Ser Lys His Asn Arg Ser 
65                  70                  75                  80  


Asn Ile Gly Thr Glu Gly Gly Pro Pro Pro Phe Val Pro Phe Gly Gln 
                85                  90                  95      


Lys Cys Val Ser His Val Gln Val Asp Ser Arg Glu Leu Asp Arg Arg 
            100                 105                 110         


Lys Thr Leu Gln Val Thr Met Pro Val Lys Pro Thr Asn Asp Asn Asp 
        115                 120                 125             


Glu Phe Glu Lys Gln Arg Thr Ala Ala Ile Ala Glu Val Ala Lys Ser 
    130                 135                 140                 


Lys Glu Thr Lys Thr Phe Gly Gly Gly Gly Gly Gly Ala Arg Ser Asn 
145                 150                 155                 160 


Leu Asn Met Asn Ala Ala Gly Asn Arg Asn Arg Glu Val Leu Gln Lys 
                165                 170                 175     


Glu Lys Ser Thr Lys Ser Glu Gly Lys His Glu Gly Val Tyr Arg Glu 
            180                 185                 190         


Leu Val Asp Glu Lys Ala Leu Lys His Ile Thr Glu Met Gly Phe Ser 
        195                 200                 205             


Lys Glu Ala Ser Arg Gln Ala Leu Met Asp Asn Gly Asn Asn Leu Glu 
    210                 215                 220                 


Ala Ala Leu Asn Val Leu Leu Thr Ser Asn Lys Gln Lys Pro Val Met 
225                 230                 235                 240 


Gly Pro Pro Leu Arg Gly Arg Gly Lys Gly Arg Gly Arg Ile Arg Ser 
                245                 250                 255     


Glu Asp Glu Glu Asp Leu Gly Asn Ala Arg Pro Ser Ala Pro Ser Thr 
            260                 265                 270         


Leu Phe Asp Phe Leu Glu Ser Lys Met Gly Thr Leu Asn Val Glu Glu 
        275                 280                 285             


Pro Lys Ser Gln Pro Gln Gln Leu His Gln Gly Gln Tyr Arg Ser Ser 
    290                 295                 300                 


Asn Thr Glu Gln Asn Gly Val Lys Asp Asn Asn His Leu Arg His Pro 
305                 310                 315                 320 


Pro Arg Asn Asp Thr Arg Gln Pro Arg Asn Glu Lys Pro Pro Arg Phe 
                325                 330                 335     


Gln Arg Asp Ser Gln Asn Ser Lys Ser Val Leu Glu Gly Ser Gly Leu 
            340                 345                 350         


Pro Arg Asn Arg Gly Ser Glu Arg Pro Ser Thr Ser Ser Val Ser Glu 
        355                 360                 365             


Val Trp Ala Glu Asp Arg Ile Lys Cys Asp Arg Pro Tyr Ser Arg Tyr 
    370                 375                 380                 


Asp Arg Thr Lys Asp Thr Ser Tyr Pro Leu Gly Ser Gln His Ser Asp 
385                 390                 395                 400 


Gly Ala Phe Lys Lys Arg Asp Asn Ser Met Gln Ser Arg Ser Gly Lys 
                405                 410                 415     


Gly Pro Ser Phe Ala Glu Ala Lys Glu Asn Pro Leu Pro Gln Gly Ser 
            420                 425                 430         


Val Asp Tyr Asn Asn Gln Lys Arg Gly Lys Arg Glu Ser Gln Thr Ser 
        435                 440                 445             


Ile Pro Asp Tyr Phe Tyr Asp Arg Lys Ser Gln Thr Ile Asn Asn Glu 
    450                 455                 460                 


Ala Phe Ser Gly Ile Lys Ile Glu Lys His Phe Asn Val Asn Thr Asp 
465                 470                 475                 480 


Tyr Gln Asn Pro Val Arg Ser Asn Ser Phe Ile Gly Val Pro Asn Gly 
                485                 490                 495     


Glu Val Glu Met Pro Leu Lys Gly Arg Arg Ile Gly Pro Ile Lys Pro 
            500                 505                 510         


Ala Gly Pro Val Thr Ala Val Pro Cys Asp Asp Lys Ile Phe Tyr Asn 
        515                 520                 525             


Ser Gly Pro Lys Arg Arg Ser Gly Pro Ile Lys Pro Glu Lys Ile Leu 
    530                 535                 540                 


Glu Ser Ser Ile Pro Met Glu Tyr Ala Lys Met Trp Lys Pro Gly Asp 
545                 550                 555                 560 


Glu Cys Phe Ala Leu Tyr Trp Glu Asp Asn Lys Phe Tyr Arg Ala Glu 
                565                 570                 575     


Val Glu Ala Leu His Ser Ser Gly Met Thr Ala Val Val Lys Phe Ile 
            580                 585                 590         


Asp Tyr Gly Asn Tyr Glu Glu Val Leu Leu Ser Asn Ile Lys Pro Ile 
        595                 600                 605             


Gln Thr Glu Ala Trp Glu Glu Glu Gly Thr Tyr Asp Gln Thr Leu Glu 
    610                 615                 620                 


Phe Arg Arg Gly Gly Asp Gly Gln Pro Arg Arg Ser Thr Arg Pro Thr 
625                 630                 635                 640 


Gln Gln Phe Tyr Gln Pro Pro Arg Ala Arg Asn 
                645                 650     


<210>  714
<211>  651
<212>  PRT
<213>  Homo sapiens

<400>  714

Met Leu Arg Leu Gln Met Thr Asp Gly His Ile Ser Cys Thr Ala Val 
1               5                   10                  15      


Glu Phe Ser Tyr Met Ser Lys Ile Ser Leu Asn Thr Pro Pro Gly Thr 
            20                  25                  30          


Lys Val Lys Leu Ser Gly Ile Val Asp Ile Lys Asn Gly Phe Leu Leu 
        35                  40                  45              


Leu Asn Asp Ser Asn Thr Thr Val Leu Gly Gly Glu Val Glu His Leu 
    50                  55                  60                  


Ile Glu Lys Trp Glu Leu Gln Arg Ser Leu Ser Lys His Asn Arg Ser 
65                  70                  75                  80  


Asn Ile Gly Thr Glu Gly Gly Pro Pro Pro Phe Val Pro Phe Gly Gln 
                85                  90                  95      


Lys Cys Val Ser His Val Gln Val Asp Ser Arg Glu Leu Asp Arg Arg 
            100                 105                 110         


Lys Thr Leu Gln Val Thr Met Pro Val Lys Pro Thr Asn Asp Asn Asp 
        115                 120                 125             


Glu Phe Glu Lys Gln Arg Thr Ala Ala Ile Ala Glu Val Ala Lys Ser 
    130                 135                 140                 


Lys Glu Thr Lys Thr Phe Gly Gly Gly Gly Gly Gly Ala Arg Ser Asn 
145                 150                 155                 160 


Leu Asn Met Asn Ala Ala Gly Asn Arg Asn Arg Glu Val Leu Gln Lys 
                165                 170                 175     


Glu Lys Ser Thr Lys Ser Glu Gly Lys His Glu Gly Val Tyr Arg Glu 
            180                 185                 190         


Leu Val Asp Glu Lys Ala Leu Lys His Ile Thr Glu Met Gly Phe Ser 
        195                 200                 205             


Lys Glu Ala Ser Arg Gln Ala Leu Met Asp Asn Gly Asn Asn Leu Glu 
    210                 215                 220                 


Ala Ala Leu Asn Val Leu Leu Thr Ser Asn Lys Gln Lys Pro Val Met 
225                 230                 235                 240 


Gly Pro Pro Leu Arg Gly Arg Gly Lys Gly Arg Gly Arg Ile Arg Ser 
                245                 250                 255     


Glu Asp Glu Glu Asp Leu Gly Asn Ala Arg Pro Ser Ala Pro Ser Thr 
            260                 265                 270         


Leu Phe Asp Phe Leu Glu Ser Lys Met Gly Thr Leu Asn Val Glu Glu 
        275                 280                 285             


Pro Lys Ser Gln Pro Gln Gln Leu His Gln Gly Gln Tyr Arg Ser Ser 
    290                 295                 300                 


Asn Thr Glu Gln Asn Gly Val Lys Asp Asn Asn His Leu Arg His Pro 
305                 310                 315                 320 


Pro Arg Asn Asp Thr Arg Gln Pro Arg Asn Glu Lys Pro Pro Arg Phe 
                325                 330                 335     


Gln Arg Asp Ser Gln Asn Ser Lys Ser Val Leu Glu Gly Ser Gly Leu 
            340                 345                 350         


Pro Arg Asn Arg Gly Ser Glu Arg Pro Ser Thr Ser Ser Val Ser Glu 
        355                 360                 365             


Val Trp Ala Glu Asp Arg Ile Lys Cys Asp Arg Pro Tyr Ser Arg Tyr 
    370                 375                 380                 


Asp Arg Thr Lys Asp Thr Ser Tyr Pro Leu Gly Ser Gln His Ser Asp 
385                 390                 395                 400 


Gly Ala Phe Lys Lys Arg Asp Asn Ser Met Gln Ser Arg Ser Gly Lys 
                405                 410                 415     


Gly Pro Ser Phe Ala Glu Ala Lys Glu Asn Pro Leu Pro Gln Gly Ser 
            420                 425                 430         


Val Asp Tyr Asn Asn Gln Lys Arg Gly Lys Arg Glu Ser Gln Thr Ser 
        435                 440                 445             


Ile Pro Asp Tyr Phe Tyr Asp Arg Lys Ser Gln Thr Ile Asn Asn Glu 
    450                 455                 460                 


Ala Phe Ser Gly Ile Lys Ile Glu Lys His Phe Asn Val Asn Thr Asp 
465                 470                 475                 480 


Tyr Gln Asn Pro Val Arg Ser Asn Ser Phe Ile Gly Val Pro Asn Gly 
                485                 490                 495     


Glu Val Glu Met Pro Leu Lys Gly Arg Arg Ile Gly Pro Ile Lys Pro 
            500                 505                 510         


Ala Gly Pro Val Thr Ala Val Pro Cys Asp Asp Lys Ile Phe Tyr Asn 
        515                 520                 525             


Ser Gly Pro Lys Arg Arg Ser Gly Pro Ile Lys Pro Glu Lys Ile Leu 
    530                 535                 540                 


Glu Ser Ser Ile Pro Met Glu Tyr Ala Lys Met Trp Lys Pro Gly Asp 
545                 550                 555                 560 


Glu Cys Phe Ala Leu Tyr Trp Glu Asp Asn Lys Phe Tyr Arg Ala Glu 
                565                 570                 575     


Val Glu Ala Leu His Ser Ser Gly Met Thr Ala Val Val Lys Phe Ile 
            580                 585                 590         


Asp Tyr Gly Asn Tyr Glu Glu Val Leu Leu Ser Asn Ile Lys Pro Ile 
        595                 600                 605             


Gln Thr Glu Ala Trp Glu Glu Glu Gly Thr Tyr Asp Gln Thr Leu Glu 
    610                 615                 620                 


Phe Arg Arg Gly Gly Asp Gly Gln Pro Arg Arg Ser Thr Arg Pro Thr 
625                 630                 635                 640 


Gln Gln Phe Tyr Gln Pro Pro Arg Ala Arg Asn 
                645                 650     


<210>  715
<211>  129
<212>  PRT
<213>  Homo sapiens

<400>  715

Met Leu Arg Leu Gln Met Thr Asp Gly His Ile Ser Cys Thr Ala Val 
1               5                   10                  15      


Glu Phe Ser Tyr Met Ser Lys Ile Ser Leu Asn Thr Pro Pro Gly Thr 
            20                  25                  30          


Lys Val Lys Leu Ser Gly Ile Val Asp Ile Lys Asn Gly Phe Leu Leu 
        35                  40                  45              


Leu Asn Asp Ser Asn Thr Thr Val Leu Gly Gly Glu Val Glu His Leu 
    50                  55                  60                  


Ile Glu Lys Trp Glu Leu Gln Arg Ser Leu Ser Lys His Asn Arg Ser 
65                  70                  75                  80  


Asn Ile Gly Thr Glu Gly Gly Pro Pro Pro Phe Val Pro Phe Gly Gln 
                85                  90                  95      


Lys Cys Val Ser His Val Gln Val Asp Ser Arg Glu Leu Asp Arg Arg 
            100                 105                 110         


Lys Thr Leu Gln Val Thr Met Pro Val Lys Pro Thr Asn Asp Asn Asp 
        115                 120                 125             


Glu 
    


<210>  716
<211>  744
<212>  PRT
<213>  Homo sapiens

<400>  716

Met Ala Gln Val Ala Gly Ala Ala Leu Ser Gln Ala Gly Trp Tyr Leu 
1               5                   10                  15      


Ser Asp Glu Gly Ile Glu Ala Cys Thr Ser Ser Pro Asp Lys Val Asn 
            20                  25                  30          


Val Asn Asp Ile Ile Leu Ile Ala Leu Asn Thr Asp Leu Arg Thr Ile 
        35                  40                  45              


Gly Lys Lys Phe Leu Pro Ser Asp Ile Asn Ser Gly Lys Val Glu Lys 
    50                  55                  60                  


Leu Glu Gly Pro Cys Val Leu Gln Ile Gln Lys Ile Arg Asn Val Ala 
65                  70                  75                  80  


Ala Pro Lys Asp Asn Glu Glu Ser Gln Ala Ala Pro Arg Met Leu Arg 
                85                  90                  95      


Leu Gln Met Thr Asp Gly His Ile Ser Cys Thr Ala Val Glu Phe Ser 
            100                 105                 110         


Tyr Met Ser Lys Ile Ser Leu Asn Thr Pro Pro Gly Thr Lys Val Lys 
        115                 120                 125             


Leu Ser Gly Ile Val Asp Ile Lys Asn Gly Phe Leu Leu Leu Asn Asp 
    130                 135                 140                 


Ser Asn Thr Thr Val Leu Gly Gly Glu Val Glu His Leu Ile Glu Lys 
145                 150                 155                 160 


Trp Glu Leu Gln Arg Ser Leu Ser Lys His Asn Arg Ser Asn Ile Gly 
                165                 170                 175     


Thr Glu Gly Gly Pro Pro Pro Phe Val Pro Phe Gly Gln Lys Cys Val 
            180                 185                 190         


Ser His Val Gln Val Asp Ser Arg Glu Leu Asp Arg Arg Lys Thr Leu 
        195                 200                 205             


Gln Val Thr Met Pro Val Lys Pro Thr Asn Asp Asn Asp Glu Phe Glu 
    210                 215                 220                 


Lys Gln Arg Thr Ala Ala Ile Ala Glu Val Ala Lys Ser Lys Glu Thr 
225                 230                 235                 240 


Lys Thr Phe Gly Gly Gly Gly Gly Gly Ala Arg Ser Asn Leu Asn Met 
                245                 250                 255     


Asn Ala Ala Gly Asn Arg Asn Arg Glu Val Leu Gln Lys Glu Lys Ser 
            260                 265                 270         


Thr Lys Ser Glu Gly Lys His Glu Gly Val Tyr Arg Glu Leu Val Asp 
        275                 280                 285             


Glu Lys Ala Leu Lys His Ile Thr Glu Met Gly Phe Ser Lys Glu Ala 
    290                 295                 300                 


Ser Arg Gln Ala Leu Met Asp Asn Gly Asn Asn Leu Glu Ala Ala Leu 
305                 310                 315                 320 


Asn Val Leu Leu Thr Ser Asn Lys Gln Lys Pro Val Met Gly Pro Pro 
                325                 330                 335     


Leu Arg Gly Arg Gly Lys Gly Arg Gly Arg Ile Arg Ser Glu Asp Glu 
            340                 345                 350         


Glu Asp Leu Gly Asn Ala Arg Pro Ser Ala Pro Ser Thr Leu Phe Asp 
        355                 360                 365             


Phe Leu Glu Ser Lys Met Gly Thr Leu Asn Val Glu Glu Pro Lys Ser 
    370                 375                 380                 


Gln Pro Gln Gln Leu His Gln Gly Gln Tyr Arg Ser Ser Asn Thr Glu 
385                 390                 395                 400 


Gln Asn Gly Val Lys Asp Asn Asn His Leu Arg His Pro Pro Arg Asn 
                405                 410                 415     


Asp Thr Arg Gln Pro Arg Asn Glu Lys Pro Pro Arg Phe Gln Arg Asp 
            420                 425                 430         


Ser Gln Asn Ser Lys Ser Val Leu Glu Gly Ser Gly Leu Pro Arg Asn 
        435                 440                 445             


Arg Gly Ser Glu Arg Pro Ser Thr Ser Ser Val Ser Glu Val Trp Ala 
    450                 455                 460                 


Glu Asp Arg Ile Lys Cys Asp Arg Pro Tyr Ser Arg Tyr Asp Arg Thr 
465                 470                 475                 480 


Lys Asp Thr Ser Tyr Pro Leu Gly Ser Gln His Ser Asp Gly Ala Phe 
                485                 490                 495     


Lys Lys Arg Asp Asn Ser Met Gln Ser Arg Ser Gly Lys Gly Pro Ser 
            500                 505                 510         


Phe Ala Glu Ala Lys Glu Asn Pro Leu Pro Gln Gly Ser Val Asp Tyr 
        515                 520                 525             


Asn Asn Gln Lys Arg Gly Lys Arg Glu Ser Gln Thr Ser Ile Pro Asp 
    530                 535                 540                 


Tyr Phe Tyr Asp Arg Lys Ser Gln Thr Ile Asn Asn Glu Ala Phe Ser 
545                 550                 555                 560 


Gly Ile Lys Ile Glu Lys His Phe Asn Val Asn Thr Asp Tyr Gln Asn 
                565                 570                 575     


Pro Val Arg Ser Asn Ser Phe Ile Gly Val Pro Asn Gly Glu Val Glu 
            580                 585                 590         


Met Pro Leu Lys Gly Arg Arg Ile Gly Pro Ile Lys Pro Ala Gly Pro 
        595                 600                 605             


Val Thr Ala Val Pro Cys Asp Asp Lys Ile Phe Tyr Asn Ser Gly Pro 
    610                 615                 620                 


Lys Arg Arg Ser Gly Pro Ile Lys Pro Glu Lys Ile Leu Glu Ser Ser 
625                 630                 635                 640 


Ile Pro Met Glu Tyr Ala Lys Met Trp Lys Pro Gly Asp Glu Cys Phe 
                645                 650                 655     


Ala Leu Tyr Trp Glu Asp Asn Lys Phe Tyr Arg Ala Glu Val Glu Ala 
            660                 665                 670         


Leu His Ser Ser Gly Met Thr Ala Val Val Lys Phe Ile Asp Tyr Gly 
        675                 680                 685             


Asn Tyr Glu Glu Val Leu Leu Ser Asn Ile Lys Pro Ile Gln Thr Glu 
    690                 695                 700                 


Ala Trp Glu Glu Glu Gly Thr Tyr Asp Gln Thr Leu Glu Phe Arg Arg 
705                 710                 715                 720 


Gly Gly Asp Gly Gln Pro Arg Arg Ser Thr Arg Pro Thr Gln Gln Phe 
                725                 730                 735     


Tyr Gln Pro Pro Arg Ala Arg Asn 
            740                 


<210>  717
<211>  651
<212>  PRT
<213>  Homo sapiens

<400>  717

Met Leu Arg Leu Gln Met Thr Asp Gly His Ile Ser Cys Thr Ala Val 
1               5                   10                  15      


Glu Phe Ser Tyr Met Ser Lys Ile Ser Leu Asn Thr Pro Pro Gly Thr 
            20                  25                  30          


Lys Val Lys Leu Ser Gly Ile Val Asp Ile Lys Asn Gly Phe Leu Leu 
        35                  40                  45              


Leu Asn Asp Ser Asn Thr Thr Val Leu Gly Gly Glu Val Glu His Leu 
    50                  55                  60                  


Ile Glu Lys Trp Glu Leu Gln Arg Ser Leu Ser Lys His Asn Arg Ser 
65                  70                  75                  80  


Asn Ile Gly Thr Glu Gly Gly Pro Pro Pro Phe Val Pro Phe Gly Gln 
                85                  90                  95      


Lys Cys Val Ser His Val Gln Val Asp Ser Arg Glu Leu Asp Arg Arg 
            100                 105                 110         


Lys Thr Leu Gln Val Thr Met Pro Val Lys Pro Thr Asn Asp Asn Asp 
        115                 120                 125             


Glu Phe Glu Lys Gln Arg Thr Ala Ala Ile Ala Glu Val Ala Lys Ser 
    130                 135                 140                 


Lys Glu Thr Lys Thr Phe Gly Gly Gly Gly Gly Gly Ala Arg Ser Asn 
145                 150                 155                 160 


Leu Asn Met Asn Ala Ala Gly Asn Arg Asn Arg Glu Val Leu Gln Lys 
                165                 170                 175     


Glu Lys Ser Thr Lys Ser Glu Gly Lys His Glu Gly Val Tyr Arg Glu 
            180                 185                 190         


Leu Val Asp Glu Lys Ala Leu Lys His Ile Thr Glu Met Gly Phe Ser 
        195                 200                 205             


Lys Glu Ala Ser Arg Gln Ala Leu Met Asp Asn Gly Asn Asn Leu Glu 
    210                 215                 220                 


Ala Ala Leu Asn Val Leu Leu Thr Ser Asn Lys Gln Lys Pro Val Met 
225                 230                 235                 240 


Gly Pro Pro Leu Arg Gly Arg Gly Lys Gly Arg Gly Arg Ile Arg Ser 
                245                 250                 255     


Glu Asp Glu Glu Asp Leu Gly Asn Ala Arg Pro Ser Ala Pro Ser Thr 
            260                 265                 270         


Leu Phe Asp Phe Leu Glu Ser Lys Met Gly Thr Leu Asn Val Glu Glu 
        275                 280                 285             


Pro Lys Ser Gln Pro Gln Gln Leu His Gln Gly Gln Tyr Arg Ser Ser 
    290                 295                 300                 


Asn Thr Glu Gln Asn Gly Val Lys Asp Asn Asn His Leu Arg His Pro 
305                 310                 315                 320 


Pro Arg Asn Asp Thr Arg Gln Pro Arg Asn Glu Lys Pro Pro Arg Phe 
                325                 330                 335     


Gln Arg Asp Ser Gln Asn Ser Lys Ser Val Leu Glu Gly Ser Gly Leu 
            340                 345                 350         


Pro Arg Asn Arg Gly Ser Glu Arg Pro Ser Thr Ser Ser Val Ser Glu 
        355                 360                 365             


Val Trp Ala Glu Asp Arg Ile Lys Cys Asp Arg Pro Tyr Ser Arg Tyr 
    370                 375                 380                 


Asp Arg Thr Lys Asp Thr Ser Tyr Pro Leu Gly Ser Gln His Ser Asp 
385                 390                 395                 400 


Gly Ala Phe Lys Lys Arg Asp Asn Ser Met Gln Ser Arg Ser Gly Lys 
                405                 410                 415     


Gly Pro Ser Phe Ala Glu Ala Lys Glu Asn Pro Leu Pro Gln Gly Ser 
            420                 425                 430         


Val Asp Tyr Asn Asn Gln Lys Arg Gly Lys Arg Glu Ser Gln Thr Ser 
        435                 440                 445             


Ile Pro Asp Tyr Phe Tyr Asp Arg Lys Ser Gln Thr Ile Asn Asn Glu 
    450                 455                 460                 


Ala Phe Ser Gly Ile Lys Ile Glu Lys His Phe Asn Val Asn Thr Asp 
465                 470                 475                 480 


Tyr Gln Asn Pro Val Arg Ser Asn Ser Phe Ile Gly Val Pro Asn Gly 
                485                 490                 495     


Glu Val Glu Met Pro Leu Lys Gly Arg Arg Ile Gly Pro Ile Lys Pro 
            500                 505                 510         


Ala Gly Pro Val Thr Ala Val Pro Cys Asp Asp Lys Ile Phe Tyr Asn 
        515                 520                 525             


Ser Gly Pro Lys Arg Arg Ser Gly Pro Ile Lys Pro Glu Lys Ile Leu 
    530                 535                 540                 


Glu Ser Ser Ile Pro Met Glu Tyr Ala Lys Met Trp Lys Pro Gly Asp 
545                 550                 555                 560 


Glu Cys Phe Ala Leu Tyr Trp Glu Asp Asn Lys Phe Tyr Arg Ala Glu 
                565                 570                 575     


Val Glu Ala Leu His Ser Ser Gly Met Thr Ala Val Val Lys Phe Ile 
            580                 585                 590         


Asp Tyr Gly Asn Tyr Glu Glu Val Leu Leu Ser Asn Ile Lys Pro Ile 
        595                 600                 605             


Gln Thr Glu Ala Trp Glu Glu Glu Gly Thr Tyr Asp Gln Thr Leu Glu 
    610                 615                 620                 


Phe Arg Arg Gly Gly Asp Gly Gln Pro Arg Arg Ser Thr Arg Pro Thr 
625                 630                 635                 640 


Gln Gln Phe Tyr Gln Pro Pro Arg Ala Arg Asn 
                645                 650     


<210>  718
<211>  650
<212>  PRT
<213>  Homo sapiens

<400>  718

Met Leu Arg Leu Gln Met Thr Asp Gly His Ile Ser Cys Thr Ala Val 
1               5                   10                  15      


Glu Phe Ser Tyr Met Ser Lys Ile Ser Leu Asn Thr Pro Pro Gly Thr 
            20                  25                  30          


Lys Val Lys Leu Ser Gly Ile Val Asp Ile Lys Asn Gly Phe Leu Leu 
        35                  40                  45              


Leu Asn Asp Ser Asn Thr Thr Val Leu Gly Gly Glu Val Glu His Leu 
    50                  55                  60                  


Ile Glu Lys Trp Glu Leu Gln Arg Ser Leu Ser Lys His Asn Arg Ser 
65                  70                  75                  80  


Asn Ile Gly Thr Glu Gly Gly Pro Pro Pro Phe Val Pro Phe Gly Gln 
                85                  90                  95      


Cys Val Ser His Val Gln Val Asp Ser Arg Glu Leu Asp Arg Arg Lys 
            100                 105                 110         


Thr Leu Gln Val Thr Met Pro Val Lys Pro Thr Asn Asp Asn Asp Glu 
        115                 120                 125             


Phe Glu Lys Gln Arg Thr Ala Ala Ile Ala Glu Val Ala Lys Ser Lys 
    130                 135                 140                 


Glu Thr Lys Thr Phe Gly Gly Gly Gly Gly Gly Ala Arg Ser Asn Leu 
145                 150                 155                 160 


Asn Met Asn Ala Ala Gly Asn Arg Asn Arg Glu Val Leu Gln Lys Glu 
                165                 170                 175     


Lys Ser Thr Lys Ser Glu Gly Lys His Glu Gly Val Tyr Arg Glu Leu 
            180                 185                 190         


Val Asp Glu Lys Ala Leu Lys His Ile Thr Glu Met Gly Phe Ser Lys 
        195                 200                 205             


Glu Ala Ser Arg Gln Ala Leu Met Asp Asn Gly Asn Asn Leu Glu Ala 
    210                 215                 220                 


Ala Leu Asn Val Leu Leu Thr Ser Asn Lys Gln Lys Pro Val Met Gly 
225                 230                 235                 240 


Pro Pro Leu Arg Gly Arg Gly Lys Gly Arg Gly Arg Ile Arg Ser Glu 
                245                 250                 255     


Asp Glu Glu Asp Leu Gly Asn Ala Arg Pro Ser Ala Pro Ser Thr Leu 
            260                 265                 270         


Phe Asp Phe Leu Glu Ser Lys Met Gly Thr Leu Asn Val Glu Glu Pro 
        275                 280                 285             


Lys Ser Gln Pro Gln Gln Leu His Gln Gly Gln Tyr Arg Ser Ser Asn 
    290                 295                 300                 


Thr Glu Gln Asn Gly Val Lys Asp Asn Asn His Leu Arg His Pro Pro 
305                 310                 315                 320 


Arg Asn Asp Thr Arg Gln Pro Arg Asn Glu Lys Pro Pro Arg Phe Gln 
                325                 330                 335     


Arg Asp Ser Gln Asn Ser Lys Ser Val Leu Glu Gly Ser Gly Leu Pro 
            340                 345                 350         


Arg Asn Arg Gly Ser Glu Arg Pro Ser Thr Ser Ser Val Ser Glu Val 
        355                 360                 365             


Trp Ala Glu Asp Arg Ile Lys Cys Asp Arg Pro Tyr Ser Arg Tyr Asp 
    370                 375                 380                 


Arg Thr Lys Asp Thr Ser Tyr Pro Leu Gly Ser Gln His Ser Asp Gly 
385                 390                 395                 400 


Ala Phe Lys Lys Arg Asp Asn Ser Met Gln Ser Arg Ser Gly Lys Gly 
                405                 410                 415     


Pro Ser Phe Ala Glu Ala Lys Glu Asn Pro Leu Pro Gln Gly Ser Val 
            420                 425                 430         


Asp Tyr Asn Asn Gln Lys Arg Gly Lys Arg Glu Ser Gln Thr Ser Ile 
        435                 440                 445             


Pro Asp Tyr Phe Tyr Asp Arg Lys Ser Gln Thr Ile Asn Asn Glu Ala 
    450                 455                 460                 


Phe Ser Gly Ile Lys Ile Glu Lys His Phe Asn Val Asn Thr Asp Tyr 
465                 470                 475                 480 


Gln Asn Pro Val Arg Ser Asn Ser Phe Ile Gly Val Pro Asn Gly Glu 
                485                 490                 495     


Val Glu Met Pro Leu Lys Gly Arg Arg Ile Gly Pro Ile Lys Pro Ala 
            500                 505                 510         


Gly Pro Val Thr Ala Val Pro Cys Asp Asp Lys Ile Phe Tyr Asn Ser 
        515                 520                 525             


Gly Pro Lys Arg Arg Ser Gly Pro Ile Lys Pro Glu Lys Ile Leu Glu 
    530                 535                 540                 


Ser Ser Ile Pro Met Glu Tyr Ala Lys Met Trp Lys Pro Gly Asp Glu 
545                 550                 555                 560 


Cys Phe Ala Leu Tyr Trp Glu Asp Asn Lys Phe Tyr Arg Ala Glu Val 
                565                 570                 575     


Glu Ala Leu His Ser Ser Gly Met Thr Ala Val Val Lys Phe Ile Asp 
            580                 585                 590         


Tyr Gly Asn Tyr Glu Glu Val Leu Leu Ser Asn Ile Lys Pro Ile Gln 
        595                 600                 605             


Thr Glu Ala Trp Glu Glu Glu Gly Thr Tyr Asp Gln Thr Leu Glu Phe 
    610                 615                 620                 


Arg Arg Gly Gly Asp Gly Gln Pro Arg Arg Ser Thr Arg Pro Thr Gln 
625                 630                 635                 640 


Gln Phe Tyr Gln Pro Pro Arg Ala Arg Asn 
                645                 650 


<210>  719
<211>  832
<212>  PRT
<213>  Homo sapiens

<400>  719

Met Ser Glu Ala Gly Gly Ala Gly Pro Gly Gly Cys Gly Ala Gly Ala 
1               5                   10                  15      


Gly Ala Gly Ala Gly Pro Gly Ala Leu Pro Pro Gln Pro Ala Ala Leu 
            20                  25                  30          


Pro Pro Ala Pro Pro Gln Gly Ser Pro Cys Ala Ala Ala Ala Gly Gly 
        35                  40                  45              


Ser Gly Ala Cys Gly Pro Ala Thr Ala Val Ala Ala Ala Gly Thr Ala 
    50                  55                  60                  


Glu Gly Pro Gly Gly Gly Gly Ser Ala Arg Ile Ala Val Lys Lys Ala 
65                  70                  75                  80  


Gln Leu Arg Ser Ala Pro Arg Ala Lys Lys Leu Glu Lys Leu Gly Val 
                85                  90                  95      


Tyr Ser Ala Cys Lys Ala Glu Glu Ser Cys Lys Cys Asn Gly Trp Lys 
            100                 105                 110         


Asn Pro Asn Pro Ser Pro Thr Pro Pro Arg Ala Asp Leu Gln Gln Ile 
        115                 120                 125             


Ile Val Ser Leu Thr Glu Ser Cys Arg Ser Cys Ser His Ala Leu Ala 
    130                 135                 140                 


Ala His Val Ser His Leu Glu Asn Val Ser Glu Glu Glu Met Asn Arg 
145                 150                 155                 160 


Leu Leu Gly Ile Val Leu Asp Val Glu Tyr Leu Phe Thr Cys Val His 
                165                 170                 175     


Lys Glu Glu Asp Ala Asp Thr Lys Gln Val Tyr Phe Tyr Leu Phe Lys 
            180                 185                 190         


Leu Leu Arg Lys Ser Ile Leu Gln Arg Gly Lys Pro Val Val Glu Gly 
        195                 200                 205             


Ser Leu Glu Lys Lys Pro Pro Phe Glu Lys Pro Ser Ile Glu Gln Gly 
    210                 215                 220                 


Val Asn Asn Phe Val Gln Tyr Lys Phe Ser His Leu Pro Ala Lys Glu 
225                 230                 235                 240 


Arg Gln Thr Ile Val Glu Leu Ala Lys Met Phe Leu Asn Arg Ile Asn 
                245                 250                 255     


Tyr Trp His Leu Glu Ala Pro Ser Gln Arg Arg Leu Arg Ser Pro Asn 
            260                 265                 270         


Asp Asp Ile Ser Gly Tyr Lys Glu Asn Tyr Thr Arg Trp Leu Cys Tyr 
        275                 280                 285             


Cys Asn Val Pro Gln Phe Cys Asp Ser Leu Pro Arg Tyr Glu Thr Thr 
    290                 295                 300                 


Gln Val Phe Gly Arg Thr Leu Leu Arg Ser Val Phe Thr Val Met Arg 
305                 310                 315                 320 


Arg Gln Leu Leu Glu Gln Ala Arg Gln Glu Lys Asp Lys Leu Pro Leu 
                325                 330                 335     


Glu Lys Arg Thr Leu Ile Leu Thr His Phe Pro Lys Phe Leu Ser Met 
            340                 345                 350         


Leu Glu Glu Glu Val Tyr Ser Gln Asn Ser Pro Ile Trp Asp Gln Asp 
        355                 360                 365             


Phe Leu Ser Ala Ser Ser Arg Thr Ser Gln Leu Gly Ile Gln Thr Val 
    370                 375                 380                 


Ile Asn Pro Pro Pro Val Ala Gly Thr Ile Ser Tyr Asn Ser Thr Ser 
385                 390                 395                 400 


Ser Ser Leu Glu Gln Pro Asn Ala Gly Ser Ser Ser Pro Ala Cys Lys 
                405                 410                 415     


Ala Ser Ser Gly Leu Glu Ala Asn Pro Gly Glu Lys Arg Lys Met Thr 
            420                 425                 430         


Asp Ser His Val Leu Glu Glu Ala Lys Lys Pro Arg Val Met Gly Asp 
        435                 440                 445             


Ile Pro Met Glu Leu Ile Asn Glu Val Met Ser Thr Ile Thr Asp Pro 
    450                 455                 460                 


Ala Ala Met Leu Gly Pro Glu Thr Asn Phe Leu Ser Ala His Ser Ala 
465                 470                 475                 480 


Arg Asp Glu Ala Ala Arg Leu Glu Glu Arg Arg Gly Val Ile Glu Phe 
                485                 490                 495     


His Val Val Gly Asn Ser Leu Asn Gln Lys Pro Asn Lys Lys Ile Leu 
            500                 505                 510         


Met Trp Leu Val Gly Leu Gln Asn Val Phe Ser His Gln Leu Pro Arg 
        515                 520                 525             


Met Pro Lys Glu Tyr Ile Thr Arg Leu Val Phe Asp Pro Lys His Lys 
    530                 535                 540                 


Thr Leu Ala Leu Ile Lys Asp Gly Arg Val Ile Gly Gly Ile Cys Phe 
545                 550                 555                 560 


Arg Met Phe Pro Ser Gln Gly Phe Thr Glu Ile Val Phe Cys Ala Val 
                565                 570                 575     


Thr Ser Asn Glu Gln Val Lys Gly Tyr Gly Thr His Leu Met Asn His 
            580                 585                 590         


Leu Lys Glu Tyr His Ile Lys His Asp Ile Leu Asn Phe Leu Thr Tyr 
        595                 600                 605             


Ala Asp Glu Tyr Ala Ile Gly Tyr Phe Lys Lys Gln Gly Phe Ser Lys 
    610                 615                 620                 


Glu Ile Lys Ile Pro Lys Thr Lys Tyr Val Gly Tyr Ile Lys Asp Tyr 
625                 630                 635                 640 


Glu Gly Ala Thr Leu Met Gly Cys Glu Leu Asn Pro Arg Ile Pro Tyr 
                645                 650                 655     


Thr Glu Phe Ser Val Ile Ile Lys Lys Gln Lys Glu Ile Ile Lys Lys 
            660                 665                 670         


Leu Ile Glu Arg Lys Gln Ala Gln Ile Arg Lys Val Tyr Pro Gly Leu 
        675                 680                 685             


Ser Cys Phe Lys Asp Gly Val Arg Gln Ile Pro Ile Glu Ser Ile Pro 
    690                 695                 700                 


Gly Ile Arg Glu Thr Gly Trp Lys Pro Ser Gly Lys Glu Lys Ser Lys 
705                 710                 715                 720 


Glu Pro Arg Asp Pro Asp Gln Leu Tyr Ser Thr Leu Lys Ser Ile Leu 
                725                 730                 735     


Gln Gln Val Lys Ser His Gln Ser Ala Trp Pro Phe Met Glu Pro Val 
            740                 745                 750         


Lys Arg Thr Glu Ala Pro Gly Tyr Tyr Glu Val Ile Arg Phe Pro Met 
        755                 760                 765             


Asp Leu Lys Thr Met Ser Glu Arg Leu Lys Asn Arg Tyr Tyr Val Ser 
    770                 775                 780                 


Lys Lys Leu Phe Met Ala Asp Leu Gln Arg Val Phe Thr Asn Cys Lys 
785                 790                 795                 800 


Glu Tyr Asn Pro Pro Glu Ser Glu Tyr Tyr Lys Cys Ala Asn Ile Leu 
                805                 810                 815     


Glu Lys Phe Phe Phe Ser Lys Ile Lys Glu Ala Gly Leu Ile Asp Lys 
            820                 825                 830         


<210>  720
<211>  472
<212>  PRT
<213>  Homo sapiens

<400>  720

Met Leu Gly Thr Val Lys Met Glu Gly His Glu Thr Ser Asp Trp Asn 
1               5                   10                  15      


Ser Tyr Tyr Ala Asp Thr Gln Glu Ala Tyr Ser Ser Val Pro Val Ser 
            20                  25                  30          


Asn Met Asn Ser Gly Leu Gly Ser Met Asn Ser Met Asn Thr Tyr Met 
        35                  40                  45              


Thr Met Asn Thr Met Thr Thr Ser Gly Asn Met Thr Pro Ala Ser Phe 
    50                  55                  60                  


Asn Met Ser Tyr Ala Asn Pro Gly Leu Gly Ala Gly Leu Ser Pro Gly 
65                  70                  75                  80  


Ala Val Ala Gly Met Pro Gly Gly Ser Ala Gly Ala Met Asn Ser Met 
                85                  90                  95      


Thr Ala Ala Gly Val Thr Ala Met Gly Thr Ala Leu Ser Pro Ser Gly 
            100                 105                 110         


Met Gly Ala Met Gly Ala Gln Gln Ala Ala Ser Met Asn Gly Leu Gly 
        115                 120                 125             


Pro Tyr Ala Ala Ala Met Asn Pro Cys Met Ser Pro Met Ala Tyr Ala 
    130                 135                 140                 


Pro Ser Asn Leu Gly Arg Ser Arg Ala Gly Gly Gly Gly Asp Ala Lys 
145                 150                 155                 160 


Thr Phe Lys Arg Ser Tyr Pro His Ala Lys Pro Pro Tyr Ser Tyr Ile 
                165                 170                 175     


Ser Leu Ile Thr Met Ala Ile Gln Gln Ala Pro Ser Lys Met Leu Thr 
            180                 185                 190         


Leu Ser Glu Ile Tyr Gln Trp Ile Met Asp Leu Phe Pro Tyr Tyr Arg 
        195                 200                 205             


Gln Asn Gln Gln Arg Trp Gln Asn Ser Ile Arg His Ser Leu Ser Phe 
    210                 215                 220                 


Asn Asp Cys Phe Val Lys Val Ala Arg Ser Pro Asp Lys Pro Gly Lys 
225                 230                 235                 240 


Gly Ser Tyr Trp Thr Leu His Pro Asp Ser Gly Asn Met Phe Glu Asn 
                245                 250                 255     


Gly Cys Tyr Leu Arg Arg Gln Lys Arg Phe Lys Cys Glu Lys Gln Pro 
            260                 265                 270         


Gly Ala Gly Gly Gly Gly Gly Ser Gly Ser Gly Gly Ser Gly Ala Lys 
        275                 280                 285             


Gly Gly Pro Glu Ser Arg Lys Asp Pro Ser Gly Ala Ser Asn Pro Ser 
    290                 295                 300                 


Ala Asp Ser Pro Leu His Arg Gly Val His Gly Lys Thr Gly Gln Leu 
305                 310                 315                 320 


Glu Gly Ala Pro Ala Pro Gly Pro Ala Ala Ser Pro Gln Thr Leu Asp 
                325                 330                 335     


His Ser Gly Ala Thr Ala Thr Gly Gly Ala Ser Glu Leu Lys Thr Pro 
            340                 345                 350         


Ala Ser Ser Thr Ala Pro Pro Ile Ser Ser Gly Pro Gly Ala Leu Ala 
        355                 360                 365             


Ser Val Pro Ala Ser His Pro Ala His Gly Leu Ala Pro His Glu Ser 
    370                 375                 380                 


Gln Leu His Leu Lys Gly Asp Pro His Tyr Ser Phe Asn His Pro Phe 
385                 390                 395                 400 


Ser Ile Asn Asn Leu Met Ser Ser Ser Glu Gln Gln His Lys Leu Asp 
                405                 410                 415     


Phe Lys Ala Tyr Glu Gln Ala Leu Gln Tyr Ser Pro Tyr Gly Ser Thr 
            420                 425                 430         


Leu Pro Ala Ser Leu Pro Leu Gly Ser Ala Ser Val Thr Thr Arg Ser 
        435                 440                 445             


Pro Ile Glu Pro Ser Ala Leu Glu Pro Ala Tyr Tyr Gln Gly Val Tyr 
    450                 455                 460                 


Ser Arg Pro Val Leu Asn Thr Ser 
465                 470         


<210>  721
<211>  36
<212>  PRT
<213>  Homo sapiens

<400>  721

Met Leu Gly Thr Val Lys Met Glu Gly His Glu Thr Ser Asp Trp Asn 
1               5                   10                  15      


Ser Tyr Tyr Ala Asp Thr Gln Glu Leu Ala Ile Thr Leu Gln Lys Phe 
            20                  25                  30          


Asn Tyr His Tyr 
        35      


<210>  722
<211>  531
<212>  PRT
<213>  Homo sapiens

<400>  722

Met Val Asp Val Gly Lys Trp Pro Ile Phe Thr Leu Leu Ser Pro Gln 
1               5                   10                  15      


Glu Ile Ala Ser Ile Arg Lys Ala Cys Val Phe Gly Thr Ser Ala Ser 
            20                  25                  30          


Glu Ala Leu Tyr Val Thr Asp Asn Asp Glu Val Phe Val Phe Gly Leu 
        35                  40                  45              


Asn Tyr Ser Asn Cys Leu Gly Thr Gly Asp Asn Gln Ser Thr Leu Val 
    50                  55                  60                  


Pro Lys Lys Leu Glu Gly Leu Cys Gly Lys Lys Ile Lys Ser Leu Ser 
65                  70                  75                  80  


Tyr Gly Ser Gly Pro His Val Leu Leu Ser Thr Glu Asp Gly Val Val 
                85                  90                  95      


Tyr Ala Trp Gly His Asn Gly Tyr Ser Gln Leu Gly Asn Gly Thr Thr 
            100                 105                 110         


Asn Gln Gly Ile Ala Pro Val Gln Val Cys Thr Asn Leu Leu Ile Lys 
        115                 120                 125             


Gln Val Val Glu Val Ala Cys Gly Ser His His Ser Met Ala Leu Ala 
    130                 135                 140                 


Ala Asp Gly Glu Val Phe Ala Trp Gly Tyr Asn Asn Cys Gly Gln Val 
145                 150                 155                 160 


Gly Ser Gly Ser Thr Ala Asn Gln Pro Thr Pro Arg Lys Val Thr Asn 
                165                 170                 175     


Cys Leu His Ile Lys Arg Val Val Gly Ile Ala Cys Gly Gln Thr Ser 
            180                 185                 190         


Ser Met Ala Val Leu Asp Asn Gly Glu Val Tyr Gly Trp Gly Tyr Asn 
        195                 200                 205             


Gly Asn Gly Gln Leu Gly Leu Gly Asn Asn Gly Asn Gln Leu Thr Pro 
    210                 215                 220                 


Val Arg Val Ala Ala Leu His Ser Val Cys Val Asn Gln Ile Val Cys 
225                 230                 235                 240 


Gly Tyr Ala His Thr Leu Ala Leu Thr Asp Glu Gly Leu Leu Tyr Ala 
                245                 250                 255     


Trp Gly Ala Asn Thr Tyr Gly Gln Leu Gly Thr Gly Asn Lys Asn Asn 
            260                 265                 270         


Leu Leu Ser Pro Ala His Ile Met Val Glu Lys Glu Arg Val Val Glu 
        275                 280                 285             


Ile Ala Ala Cys His Ser Ala His Thr Ser Ala Ala Lys Thr Gln Gly 
    290                 295                 300                 


Gly His Val Tyr Met Trp Gly Gln Cys Arg Gly Gln Ser Val Ile Leu 
305                 310                 315                 320 


Pro His Leu Thr His Phe Ser Cys Thr Asp Asp Val Phe Ala Cys Phe 
                325                 330                 335     


Ala Thr Pro Ala Val Ser Trp Arg Leu Leu Ser Val Glu His Glu Asp 
            340                 345                 350         


Phe Leu Thr Val Ala Glu Ser Leu Lys Lys Glu Phe Asp Ser Pro Glu 
        355                 360                 365             


Thr Ala Asp Leu Lys Phe Arg Ile Asp Gly Lys Tyr Ile His Val His 
    370                 375                 380                 


Lys Ala Val Leu Lys Ile Arg Cys Glu His Phe Arg Ser Met Phe Gln 
385                 390                 395                 400 


Ser Tyr Trp Asn Glu Asp Met Lys Glu Val Ile Glu Ile Asp Gln Phe 
                405                 410                 415     


Ser Tyr Pro Val Tyr Arg Ala Phe Leu Gln Tyr Leu Tyr Thr Asp Thr 
            420                 425                 430         


Val Asp Leu Pro Pro Glu Asp Ala Ile Gly Leu Leu Asp Leu Ala Thr 
        435                 440                 445             


Ser Tyr Cys Glu Asn Arg Leu Lys Lys Leu Cys Gln His Ile Ile Lys 
    450                 455                 460                 


Arg Gly Ile Thr Val Glu Asn Ala Phe Ser Leu Phe Ser Ala Ala Val 
465                 470                 475                 480 


Arg Tyr Asp Ala Glu Asp Leu Glu Glu Phe Cys Phe Lys Phe Cys Ile 
                485                 490                 495     


Asn His Leu Thr Glu Val Thr Gln Thr Ala Ala Phe Trp Gln Met Asp 
            500                 505                 510         


Gly Pro Leu Leu Lys Glu Phe Ile Ala Lys Ala Ser Lys Cys Gly Ala 
        515                 520                 525             


Phe Lys Asn 
    530     


<210>  723
<211>  531
<212>  PRT
<213>  Homo sapiens

<400>  723

Met Val Asp Val Gly Lys Trp Pro Ile Phe Thr Leu Leu Ser Pro Gln 
1               5                   10                  15      


Glu Ile Ala Ser Ile Arg Lys Ala Cys Val Phe Gly Thr Ser Ala Ser 
            20                  25                  30          


Glu Ala Leu Tyr Val Thr Asp Asn Asp Glu Val Phe Val Phe Gly Leu 
        35                  40                  45              


Asn Tyr Ser Asn Cys Leu Gly Thr Gly Asp Asn Gln Ser Thr Leu Val 
    50                  55                  60                  


Pro Lys Lys Leu Glu Gly Leu Cys Gly Lys Lys Ile Lys Ser Leu Ser 
65                  70                  75                  80  


Tyr Gly Ser Gly Pro His Val Leu Leu Ser Thr Glu Asp Gly Val Val 
                85                  90                  95      


Tyr Ala Trp Gly His Asn Gly Tyr Ser Gln Leu Gly Asn Gly Thr Thr 
            100                 105                 110         


Asn Gln Gly Ile Ala Pro Val Gln Val Cys Thr Asn Leu Leu Ile Lys 
        115                 120                 125             


Gln Val Val Glu Val Ala Cys Gly Ser His His Ser Met Ala Leu Ala 
    130                 135                 140                 


Ala Asp Gly Glu Val Phe Ala Trp Gly Tyr Asn Asn Cys Gly Gln Val 
145                 150                 155                 160 


Gly Ser Gly Ser Thr Ala Asn Gln Pro Thr Pro Arg Lys Val Thr Asn 
                165                 170                 175     


Cys Leu His Ile Lys Arg Val Val Gly Ile Ala Cys Gly Gln Thr Ser 
            180                 185                 190         


Ser Met Ala Val Leu Asp Asn Gly Glu Val Tyr Gly Trp Gly Tyr Asn 
        195                 200                 205             


Gly Asn Gly Gln Leu Gly Leu Gly Asn Asn Gly Asn Gln Leu Thr Pro 
    210                 215                 220                 


Val Arg Val Ala Ala Leu His Ser Val Cys Val Asn Gln Ile Val Cys 
225                 230                 235                 240 


Gly Tyr Ala His Thr Leu Ala Leu Thr Asp Glu Gly Leu Leu Tyr Ala 
                245                 250                 255     


Trp Gly Ala Asn Thr Tyr Gly Gln Leu Gly Thr Gly Asn Lys Asn Asn 
            260                 265                 270         


Leu Leu Ser Pro Ala His Ile Met Val Glu Lys Glu Arg Val Val Glu 
        275                 280                 285             


Ile Ala Ala Cys His Ser Ala His Thr Ser Ala Ala Lys Thr Gln Gly 
    290                 295                 300                 


Gly His Val Tyr Met Trp Gly Gln Cys Arg Gly Gln Ser Val Ile Leu 
305                 310                 315                 320 


Pro His Leu Thr His Phe Ser Cys Thr Asp Asp Val Phe Ala Cys Phe 
                325                 330                 335     


Ala Thr Pro Ala Val Ser Trp Arg Leu Leu Ser Val Glu His Glu Asp 
            340                 345                 350         


Phe Leu Thr Val Ala Glu Ser Leu Lys Lys Glu Phe Asp Ser Pro Glu 
        355                 360                 365             


Thr Ala Asp Leu Lys Phe Arg Ile Asp Gly Lys Tyr Ile His Val His 
    370                 375                 380                 


Lys Ala Val Leu Lys Ile Arg Cys Glu His Phe Arg Ser Met Phe Gln 
385                 390                 395                 400 


Ser Tyr Trp Asn Glu Asp Met Lys Glu Val Ile Glu Ile Asp Gln Phe 
                405                 410                 415     


Ser Tyr Pro Val Tyr Arg Ala Phe Leu Gln Tyr Leu Tyr Thr Asp Thr 
            420                 425                 430         


Val Asp Leu Pro Pro Glu Asp Ala Ile Gly Leu Leu Asp Leu Ala Thr 
        435                 440                 445             


Ser Tyr Cys Glu Asn Arg Leu Lys Lys Leu Cys Gln His Ile Ile Lys 
    450                 455                 460                 


Arg Gly Ile Thr Val Glu Asn Ala Phe Ser Leu Phe Ser Ala Ala Val 
465                 470                 475                 480 


Arg Tyr Asp Ala Glu Asp Leu Glu Glu Phe Cys Phe Lys Phe Cys Ile 
                485                 490                 495     


Asn His Leu Thr Glu Val Thr Gln Thr Ala Ala Phe Trp Gln Met Asp 
            500                 505                 510         


Gly Pro Leu Leu Lys Glu Phe Ile Ala Lys Ala Ser Lys Cys Gly Ala 
        515                 520                 525             


Phe Lys Asn 
    530     


<210>  724
<211>  420
<212>  PRT
<213>  Homo sapiens

<400>  724

Met Ser Gly Arg Pro Arg Thr Thr Ser Phe Ala Glu Ser Cys Lys Pro 
1               5                   10                  15      


Val Gln Gln Pro Ser Ala Phe Gly Ser Met Lys Val Ser Arg Asp Lys 
            20                  25                  30          


Asp Gly Ser Lys Val Thr Thr Val Val Ala Thr Pro Gly Gln Gly Pro 
        35                  40                  45              


Asp Arg Pro Gln Glu Val Ser Tyr Thr Asp Thr Lys Val Ile Gly Asn 
    50                  55                  60                  


Gly Ser Phe Gly Val Val Tyr Gln Ala Lys Leu Cys Asp Ser Gly Glu 
65                  70                  75                  80  


Leu Val Ala Ile Lys Lys Val Leu Gln Asp Lys Arg Phe Lys Asn Arg 
                85                  90                  95      


Glu Leu Gln Ile Met Arg Lys Leu Asp His Cys Asn Ile Val Arg Leu 
            100                 105                 110         


Arg Tyr Phe Phe Tyr Ser Ser Gly Glu Lys Lys Asp Glu Val Tyr Leu 
        115                 120                 125             


Asn Leu Val Leu Asp Tyr Val Pro Glu Thr Val Tyr Arg Val Ala Arg 
    130                 135                 140                 


His Tyr Ser Arg Ala Lys Gln Thr Leu Pro Val Ile Tyr Val Lys Leu 
145                 150                 155                 160 


Tyr Met Tyr Gln Leu Phe Arg Ser Leu Ala Tyr Ile His Ser Phe Gly 
                165                 170                 175     


Ile Cys His Arg Asp Ile Lys Pro Gln Asn Leu Leu Leu Asp Pro Asp 
            180                 185                 190         


Thr Ala Val Leu Lys Leu Cys Asp Phe Gly Ser Ala Lys Gln Leu Val 
        195                 200                 205             


Arg Gly Glu Pro Asn Val Ser Tyr Ile Cys Ser Arg Tyr Tyr Arg Ala 
    210                 215                 220                 


Pro Glu Leu Ile Phe Gly Ala Thr Asp Tyr Thr Ser Ser Ile Asp Val 
225                 230                 235                 240 


Trp Ser Ala Gly Cys Val Leu Ala Glu Leu Leu Leu Gly Gln Pro Ile 
                245                 250                 255     


Phe Pro Gly Asp Ser Gly Val Asp Gln Leu Val Glu Ile Ile Lys Val 
            260                 265                 270         


Leu Gly Thr Pro Thr Arg Glu Gln Ile Arg Glu Met Asn Pro Asn Tyr 
        275                 280                 285             


Thr Glu Phe Lys Phe Pro Gln Ile Lys Ala His Pro Trp Thr Lys Val 
    290                 295                 300                 


Phe Arg Pro Arg Thr Pro Pro Glu Ala Ile Ala Leu Cys Ser Arg Leu 
305                 310                 315                 320 


Leu Glu Tyr Thr Pro Thr Ala Arg Leu Thr Pro Leu Glu Ala Cys Ala 
                325                 330                 335     


His Ser Phe Phe Asp Glu Leu Arg Asp Pro Asn Val Lys Leu Pro Asn 
            340                 345                 350         


Gly Arg Asp Thr Pro Ala Leu Phe Asn Phe Thr Thr Gln Glu Leu Ser 
        355                 360                 365             


Ser Asn Pro Pro Leu Ala Thr Ile Leu Ile Pro Pro His Ala Arg Ile 
    370                 375                 380                 


Gln Ala Ala Ala Ser Thr Pro Thr Asn Ala Thr Ala Ala Ser Asp Ala 
385                 390                 395                 400 


Asn Thr Gly Asp Arg Gly Gln Thr Asn Asn Ala Ala Ser Ala Ser Ala 
                405                 410                 415     


Ser Asn Ser Thr 
            420 


<210>  725
<211>  433
<212>  PRT
<213>  Homo sapiens

<400>  725

Met Ser Gly Arg Pro Arg Thr Thr Ser Phe Ala Glu Ser Cys Lys Pro 
1               5                   10                  15      


Val Gln Gln Pro Ser Ala Phe Gly Ser Met Lys Val Ser Arg Asp Lys 
            20                  25                  30          


Asp Gly Ser Lys Val Thr Thr Val Val Ala Thr Pro Gly Gln Gly Pro 
        35                  40                  45              


Asp Arg Pro Gln Glu Val Ser Tyr Thr Asp Thr Lys Val Ile Gly Asn 
    50                  55                  60                  


Gly Ser Phe Gly Val Val Tyr Gln Ala Lys Leu Cys Asp Ser Gly Glu 
65                  70                  75                  80  


Leu Val Ala Ile Lys Lys Val Leu Gln Asp Lys Arg Phe Lys Asn Arg 
                85                  90                  95      


Glu Leu Gln Ile Met Arg Lys Leu Asp His Cys Asn Ile Val Arg Leu 
            100                 105                 110         


Arg Tyr Phe Phe Tyr Ser Ser Gly Glu Lys Lys Asp Glu Val Tyr Leu 
        115                 120                 125             


Asn Leu Val Leu Asp Tyr Val Pro Glu Thr Val Tyr Arg Val Ala Arg 
    130                 135                 140                 


His Tyr Ser Arg Ala Lys Gln Thr Leu Pro Val Ile Tyr Val Lys Leu 
145                 150                 155                 160 


Tyr Met Tyr Gln Leu Phe Arg Ser Leu Ala Tyr Ile His Ser Phe Gly 
                165                 170                 175     


Ile Cys His Arg Asp Ile Lys Pro Gln Asn Leu Leu Leu Asp Pro Asp 
            180                 185                 190         


Thr Ala Val Leu Lys Leu Cys Asp Phe Gly Ser Ala Lys Gln Leu Val 
        195                 200                 205             


Arg Gly Glu Pro Asn Val Ser Tyr Ile Cys Ser Arg Tyr Tyr Arg Ala 
    210                 215                 220                 


Pro Glu Leu Ile Phe Gly Ala Thr Asp Tyr Thr Ser Ser Ile Asp Val 
225                 230                 235                 240 


Trp Ser Ala Gly Cys Val Leu Ala Glu Leu Leu Leu Gly Gln Pro Ile 
                245                 250                 255     


Phe Pro Gly Asp Ser Gly Val Asp Gln Leu Val Glu Ile Ile Lys Val 
            260                 265                 270         


Leu Gly Thr Pro Thr Arg Glu Gln Ile Arg Glu Met Asn Pro Asn Tyr 
        275                 280                 285             


Thr Glu Phe Lys Phe Pro Gln Ile Lys Ala His Pro Trp Thr Lys Asp 
    290                 295                 300                 


Ser Ser Gly Thr Gly His Phe Thr Ser Gly Val Arg Val Phe Arg Pro 
305                 310                 315                 320 


Arg Thr Pro Pro Glu Ala Ile Ala Leu Cys Ser Arg Leu Leu Glu Tyr 
                325                 330                 335     


Thr Pro Thr Ala Arg Leu Thr Pro Leu Glu Ala Cys Ala His Ser Phe 
            340                 345                 350         


Phe Asp Glu Leu Arg Asp Pro Asn Val Lys Leu Pro Asn Gly Arg Asp 
        355                 360                 365             


Thr Pro Ala Leu Phe Asn Phe Thr Thr Gln Glu Leu Ser Ser Asn Pro 
    370                 375                 380                 


Pro Leu Ala Thr Ile Leu Ile Pro Pro His Ala Arg Ile Gln Ala Ala 
385                 390                 395                 400 


Ala Ser Thr Pro Thr Asn Ala Thr Ala Ala Ser Asp Ala Asn Thr Gly 
                405                 410                 415     


Asp Arg Gly Gln Thr Asn Asn Ala Ala Ser Ala Ser Ala Ser Asn Ser 
            420                 425                 430         


Thr 
    


<210>  726
<211>  326
<212>  PRT
<213>  Homo sapiens

<400>  726

Met Glu Lys Asp Gly Leu Cys Arg Ala Asp Gln Gln Tyr Glu Cys Val 
1               5                   10                  15      


Ala Glu Ile Gly Glu Gly Ala Tyr Gly Lys Val Phe Lys Ala Arg Asp 
            20                  25                  30          


Leu Lys Asn Gly Gly Arg Phe Val Ala Leu Lys Arg Val Arg Val Gln 
        35                  40                  45              


Thr Gly Glu Glu Gly Met Pro Leu Ser Thr Ile Arg Glu Val Ala Val 
    50                  55                  60                  


Leu Arg His Leu Glu Thr Phe Glu His Pro Asn Val Val Arg Leu Phe 
65                  70                  75                  80  


Asp Val Cys Thr Val Ser Arg Thr Asp Arg Glu Thr Lys Leu Thr Leu 
                85                  90                  95      


Val Phe Glu His Val Asp Gln Asp Leu Thr Thr Tyr Leu Asp Lys Val 
            100                 105                 110         


Pro Glu Pro Gly Val Pro Thr Glu Thr Ile Lys Asp Met Met Phe Gln 
        115                 120                 125             


Leu Leu Arg Gly Leu Asp Phe Leu His Ser His Arg Val Val His Arg 
    130                 135                 140                 


Asp Leu Lys Pro Gln Asn Ile Leu Val Thr Ser Ser Gly Gln Ile Lys 
145                 150                 155                 160 


Leu Ala Asp Phe Gly Leu Ala Arg Ile Tyr Ser Phe Gln Met Ala Leu 
                165                 170                 175     


Thr Ser Val Val Val Thr Leu Trp Tyr Arg Ala Pro Glu Val Leu Leu 
            180                 185                 190         


Gln Ser Ser Tyr Ala Thr Pro Val Asp Leu Trp Ser Val Gly Cys Ile 
        195                 200                 205             


Phe Ala Glu Met Phe Arg Arg Lys Pro Leu Phe Arg Gly Ser Ser Asp 
    210                 215                 220                 


Val Asp Gln Leu Gly Lys Ile Leu Asp Val Ile Gly Leu Pro Gly Glu 
225                 230                 235                 240 


Glu Asp Trp Pro Arg Asp Val Ala Leu Pro Arg Gln Ala Phe His Ser 
                245                 250                 255     


Lys Ser Ala Gln Pro Ile Glu Lys Phe Val Thr Asp Ile Asp Glu Leu 
            260                 265                 270         


Gly Lys Asp Leu Leu Leu Lys Cys Leu Thr Phe Asn Pro Ala Lys Arg 
        275                 280                 285             


Ile Ser Ala Tyr Ser Ala Leu Ser His Pro Tyr Phe Gln Asp Leu Glu 
    290                 295                 300                 


Arg Cys Lys Glu Asn Leu Asp Ser His Leu Pro Pro Ser Gln Asn Thr 
305                 310                 315                 320 


Ser Glu Leu Asn Thr Ala 
                325     


<210>  727
<211>  326
<212>  PRT
<213>  Homo sapiens

<400>  727

Met Glu Lys Asp Gly Leu Cys Arg Ala Asp Gln Gln Tyr Glu Cys Val 
1               5                   10                  15      


Ala Glu Ile Gly Glu Gly Ala Tyr Gly Lys Val Phe Lys Ala Arg Asp 
            20                  25                  30          


Leu Lys Asn Gly Gly Arg Phe Val Ala Leu Lys Arg Val Arg Val Gln 
        35                  40                  45              


Thr Gly Glu Glu Gly Met Pro Leu Ser Thr Ile Arg Glu Val Ala Val 
    50                  55                  60                  


Leu Arg His Leu Glu Thr Phe Glu His Pro Asn Val Val Arg Leu Phe 
65                  70                  75                  80  


Asp Val Cys Thr Val Ser Arg Thr Asp Arg Glu Thr Lys Leu Thr Leu 
                85                  90                  95      


Val Phe Glu His Val Asp Gln Asp Leu Thr Thr Tyr Leu Asp Lys Val 
            100                 105                 110         


Pro Glu Pro Gly Val Pro Thr Glu Thr Ile Lys Asp Met Met Phe Gln 
        115                 120                 125             


Leu Leu Arg Gly Leu Asp Phe Leu His Ser His Arg Val Val His Arg 
    130                 135                 140                 


Asp Leu Lys Pro Gln Asn Ile Leu Val Thr Ser Ser Gly Gln Ile Lys 
145                 150                 155                 160 


Leu Ala Asp Phe Gly Leu Ala Arg Ile Tyr Ser Phe Gln Met Ala Leu 
                165                 170                 175     


Thr Ser Val Val Val Thr Leu Trp Tyr Arg Ala Pro Glu Val Leu Leu 
            180                 185                 190         


Gln Ser Ser Tyr Ala Thr Pro Val Asp Leu Trp Ser Val Gly Cys Ile 
        195                 200                 205             


Phe Ala Glu Met Phe Arg Arg Lys Pro Leu Phe Arg Gly Ser Ser Asp 
    210                 215                 220                 


Val Asp Gln Leu Gly Lys Ile Leu Asp Val Ile Gly Leu Pro Gly Glu 
225                 230                 235                 240 


Glu Asp Trp Pro Arg Asp Val Ala Leu Pro Arg Gln Ala Phe His Ser 
                245                 250                 255     


Lys Ser Ala Gln Pro Ile Glu Lys Phe Val Thr Asp Ile Asp Glu Leu 
            260                 265                 270         


Gly Lys Asp Leu Leu Leu Lys Cys Leu Thr Phe Asn Pro Ala Lys Arg 
        275                 280                 285             


Ile Ser Ala Tyr Ser Ala Leu Ser His Pro Tyr Phe Gln Asp Leu Glu 
    290                 295                 300                 


Arg Cys Lys Glu Asn Leu Asp Ser His Leu Pro Pro Ser Gln Asn Thr 
305                 310                 315                 320 


Ser Glu Leu Asn Thr Ala 
                325     


<210>  728
<211>  113
<212>  PRT
<213>  Homo sapiens

<400>  728

Met Arg Ser Leu Gly Gln Asn Pro Thr Glu Ala Glu Leu Gln Asp Met 
1               5                   10                  15      


Ile Asn Glu Val Asp Ala Asp Gly Asn Gly Thr Ile Asp Phe Pro Glu 
            20                  25                  30          


Phe Leu Thr Met Met Ala Arg Lys Met Lys Asp Thr Asp Ser Glu Glu 
        35                  40                  45              


Glu Ile Arg Glu Ala Phe Arg Val Phe Asp Lys Asp Gly Asn Gly Tyr 
    50                  55                  60                  


Ile Ser Ala Ala Glu Leu Arg His Val Met Thr Asn Leu Gly Glu Lys 
65                  70                  75                  80  


Leu Thr Asp Glu Glu Val Asp Glu Met Ile Arg Glu Ala Asp Ile Asp 
                85                  90                  95      


Gly Asp Gly Gln Val Asn Tyr Glu Glu Phe Val Gln Met Met Thr Ala 
            100                 105                 110         


Lys 
    


<210>  729
<211>  149
<212>  PRT
<213>  Homo sapiens

<400>  729

Met Ala Asp Gln Leu Thr Glu Glu Gln Ile Ala Glu Phe Lys Glu Ala 
1               5                   10                  15      


Phe Ser Leu Phe Asp Lys Asp Gly Asp Gly Thr Ile Thr Thr Lys Glu 
            20                  25                  30          


Leu Gly Thr Val Met Arg Ser Leu Gly Gln Asn Pro Thr Glu Ala Glu 
        35                  40                  45              


Leu Gln Asp Met Ile Asn Glu Val Asp Ala Asp Gly Asn Gly Thr Ile 
    50                  55                  60                  


Asp Phe Pro Glu Phe Leu Thr Met Met Ala Arg Lys Met Lys Asp Thr 
65                  70                  75                  80  


Asp Ser Glu Glu Glu Ile Arg Glu Ala Phe Arg Val Phe Asp Lys Asp 
                85                  90                  95      


Gly Asn Gly Tyr Ile Ser Ala Ala Glu Leu Arg His Val Met Thr Asn 
            100                 105                 110         


Leu Gly Glu Lys Leu Thr Asp Glu Glu Val Asp Glu Met Ile Arg Glu 
        115                 120                 125             


Ala Asp Ile Asp Gly Asp Gly Gln Val Asn Tyr Glu Glu Phe Val Gln 
    130                 135                 140                 


Met Met Thr Ala Lys 
145                 


<210>  730
<211>  83
<212>  PRT
<213>  Homo sapiens

<400>  730

Met Ala Asp Gln Leu Thr Glu Glu Gln Ile Ala Glu Phe Lys Glu Ala 
1               5                   10                  15      


Phe Ser Leu Phe Asp Lys Asp Gly Asp Gly Thr Ile Thr Thr Lys Glu 
            20                  25                  30          


Leu Gly Thr Val Met Arg Ser Leu Gly Gln Asn Pro Thr Glu Ala Glu 
        35                  40                  45              


Leu Gln Asp Met Ile Asn Glu Val Asp Glu Met Ile Arg Glu Ala Asp 
    50                  55                  60                  


Ile Asp Gly Asp Gly Gln Val Asn Tyr Glu Glu Phe Val Gln Met Met 
65                  70                  75                  80  


Thr Ala Lys 
            


<210>  731
<211>  113
<212>  PRT
<213>  Homo sapiens

<400>  731

Met Arg Ser Leu Gly Gln Asn Pro Thr Glu Ala Glu Leu Gln Asp Met 
1               5                   10                  15      


Ile Asn Glu Val Asp Ala Asp Gly Asn Gly Thr Ile Asp Phe Pro Glu 
            20                  25                  30          


Phe Leu Thr Met Met Ala Arg Lys Met Lys Asp Thr Asp Ser Glu Glu 
        35                  40                  45              


Glu Ile Arg Glu Ala Phe Arg Val Phe Asp Lys Asp Gly Asn Gly Tyr 
    50                  55                  60                  


Ile Ser Ala Ala Glu Leu Arg His Val Met Thr Asn Leu Gly Glu Lys 
65                  70                  75                  80  


Leu Thr Asp Glu Glu Val Asp Glu Met Ile Arg Glu Ala Asp Ile Asp 
                85                  90                  95      


Gly Asp Gly Gln Val Asn Tyr Glu Glu Phe Val Gln Met Met Thr Ala 
            100                 105                 110         


Lys 
    


<210>  732
<211>  113
<212>  PRT
<213>  Homo sapiens

<400>  732

Met Arg Ser Leu Gly Gln Asn Pro Thr Glu Ala Glu Leu Gln Asp Met 
1               5                   10                  15      


Ile Asn Glu Val Asp Ala Asp Gly Asn Gly Thr Ile Asp Phe Pro Glu 
            20                  25                  30          


Phe Leu Thr Met Met Ala Arg Lys Met Lys Asp Thr Asp Ser Glu Glu 
        35                  40                  45              


Glu Ile Arg Glu Ala Phe Arg Val Phe Asp Lys Asp Gly Asn Gly Tyr 
    50                  55                  60                  


Ile Ser Ala Ala Glu Leu Arg His Val Met Thr Asn Leu Gly Glu Lys 
65                  70                  75                  80  


Leu Thr Asp Glu Glu Val Asp Glu Met Ile Arg Glu Ala Asp Ile Asp 
                85                  90                  95      


Gly Asp Gly Gln Val Asn Tyr Glu Glu Phe Val Gln Met Met Thr Ala 
            100                 105                 110         


Lys 
    


<210>  733
<211>  113
<212>  PRT
<213>  Homo sapiens

<400>  733

Met Arg Ser Leu Gly Gln Asn Pro Thr Glu Ala Glu Leu Gln Asp Met 
1               5                   10                  15      


Ile Asn Glu Val Asp Ala Asp Gly Asn Gly Thr Ile Asp Phe Pro Glu 
            20                  25                  30          


Phe Leu Thr Met Met Ala Arg Lys Met Lys Asp Thr Asp Ser Glu Glu 
        35                  40                  45              


Glu Ile Arg Glu Ala Phe Arg Val Phe Asp Lys Asp Gly Asn Gly Tyr 
    50                  55                  60                  


Ile Ser Ala Ala Glu Leu Arg His Val Met Thr Asn Leu Gly Glu Lys 
65                  70                  75                  80  


Leu Thr Asp Glu Glu Val Asp Glu Met Ile Arg Glu Ala Asp Ile Asp 
                85                  90                  95      


Gly Asp Gly Gln Val Asn Tyr Glu Glu Phe Val Gln Met Met Thr Ala 
            100                 105                 110         


Lys 
    


<210>  734
<211>  149
<212>  PRT
<213>  Homo sapiens

<400>  734

Met Ala Asp Gln Leu Thr Glu Glu Gln Ile Ala Glu Phe Lys Glu Ala 
1               5                   10                  15      


Phe Ser Leu Phe Asp Lys Asp Gly Asp Gly Thr Ile Thr Thr Lys Glu 
            20                  25                  30          


Leu Gly Thr Val Met Arg Ser Leu Gly Gln Asn Pro Thr Glu Ala Glu 
        35                  40                  45              


Leu Gln Asp Met Ile Asn Glu Val Asp Ala Asp Gly Asn Gly Thr Ile 
    50                  55                  60                  


Asp Phe Pro Glu Phe Leu Thr Met Met Ala Arg Lys Met Lys Asp Thr 
65                  70                  75                  80  


Asp Ser Glu Glu Glu Ile Arg Glu Ala Phe Arg Val Phe Asp Lys Asp 
                85                  90                  95      


Gly Asn Gly Tyr Ile Ser Ala Ala Glu Leu Arg His Val Met Thr Asn 
            100                 105                 110         


Leu Gly Glu Lys Leu Thr Asp Glu Glu Val Asp Glu Met Ile Arg Glu 
        115                 120                 125             


Ala Asp Ile Asp Gly Asp Gly Gln Val Asn Tyr Glu Glu Phe Val Gln 
    130                 135                 140                 


Met Met Thr Ala Lys 
145                 


<210>  735
<211>  474
<212>  PRT
<213>  Homo sapiens

<400>  735

Met Val Gln Gln Thr Asn Asn Ala Glu Asn Thr Glu Ala Leu Leu Ala 
1               5                   10                  15      


Gly Glu Ser Ser Asp Ser Gly Ala Gly Leu Glu Leu Gly Ile Ala Ser 
            20                  25                  30          


Ser Pro Thr Pro Gly Ser Thr Ala Ser Thr Gly Gly Lys Ala Asp Asp 
        35                  40                  45              


Pro Ser Trp Cys Lys Thr Pro Ser Gly His Ile Lys Arg Pro Met Asn 
    50                  55                  60                  


Ala Phe Met Val Trp Ser Gln Ile Glu Arg Arg Lys Ile Met Glu Gln 
65                  70                  75                  80  


Ser Pro Asp Met His Asn Ala Glu Ile Ser Lys Arg Leu Gly Lys Arg 
                85                  90                  95      


Trp Lys Leu Leu Lys Asp Ser Asp Lys Ile Pro Phe Ile Arg Glu Ala 
            100                 105                 110         


Glu Arg Leu Arg Leu Lys His Met Ala Asp Tyr Pro Asp Tyr Lys Tyr 
        115                 120                 125             


Arg Pro Arg Lys Lys Val Lys Ser Gly Asn Ala Asn Ser Ser Ser Ser 
    130                 135                 140                 


Ala Ala Ala Ser Ser Lys Pro Gly Glu Lys Gly Asp Lys Val Gly Gly 
145                 150                 155                 160 


Ser Gly Gly Gly Gly His Gly Gly Gly Gly Gly Gly Gly Ser Ser Asn 
                165                 170                 175     


Ala Gly Gly Gly Gly Gly Gly Ala Ser Gly Gly Gly Ala Asn Ser Lys 
            180                 185                 190         


Pro Ala Gln Lys Lys Ser Cys Gly Ser Lys Val Ala Gly Gly Ala Gly 
        195                 200                 205             


Gly Gly Val Ser Lys Pro His Ala Lys Leu Ile Leu Ala Gly Gly Gly 
    210                 215                 220                 


Gly Gly Gly Lys Ala Ala Ala Ala Ala Ala Ala Ser Phe Ala Ala Glu 
225                 230                 235                 240 


Gln Ala Gly Ala Ala Ala Leu Leu Pro Leu Gly Ala Ala Ala Asp His 
                245                 250                 255     


His Ser Leu Tyr Lys Ala Arg Thr Pro Ser Ala Ser Ala Ser Ala Ser 
            260                 265                 270         


Ser Ala Ala Ser Ala Ser Ala Ala Leu Ala Ala Pro Gly Lys His Leu 
        275                 280                 285             


Ala Glu Lys Lys Val Lys Arg Val Tyr Leu Phe Gly Gly Leu Gly Thr 
    290                 295                 300                 


Ser Ser Ser Pro Val Gly Gly Val Gly Ala Gly Ala Asp Pro Ser Asp 
305                 310                 315                 320 


Pro Leu Gly Leu Tyr Glu Glu Glu Gly Ala Gly Cys Ser Pro Asp Ala 
                325                 330                 335     


Pro Ser Leu Ser Gly Arg Ser Ser Ala Ala Ser Ser Pro Ala Ala Gly 
            340                 345                 350         


Arg Ser Pro Ala Asp His Arg Gly Tyr Ala Ser Leu Arg Ala Ala Ser 
        355                 360                 365             


Pro Ala Pro Ser Ser Ala Pro Ser His Ala Ser Ser Ser Ala Ser Ser 
    370                 375                 380                 


His Ser Ser Ser Ser Ser Ser Ser Gly Ser Ser Ser Ser Asp Asp Glu 
385                 390                 395                 400 


Phe Glu Asp Asp Leu Leu Asp Leu Asn Pro Ser Ser Asn Phe Glu Ser 
                405                 410                 415     


Met Ser Leu Gly Ser Phe Ser Ser Ser Ser Ala Leu Asp Arg Asp Leu 
            420                 425                 430         


Asp Phe Asn Phe Glu Pro Gly Ser Gly Ser His Phe Glu Phe Pro Asp 
        435                 440                 445             


Tyr Cys Thr Pro Glu Val Ser Glu Met Ile Ser Gly Asp Trp Leu Glu 
    450                 455                 460                 


Ser Ser Ile Ser Asn Leu Val Phe Thr Tyr 
465                 470                 


<210>  736
<211>  680
<212>  PRT
<213>  Homo sapiens

<400>  736

Met Lys Met Lys Lys Phe Gln Ile Pro Val Ser Phe Gln Asp Leu Thr 
1               5                   10                  15      


Val Asn Phe Thr Gln Glu Glu Trp Gln Gln Leu Asp Pro Ala Gln Arg 
            20                  25                  30          


Leu Leu Tyr Arg Asp Val Met Leu Glu Asn Tyr Ser Asn Leu Val Ser 
        35                  40                  45              


Val Gly Tyr His Val Ser Lys Pro Asp Val Ile Phe Lys Leu Glu Gln 
    50                  55                  60                  


Gly Glu Glu Pro Trp Ile Val Glu Glu Phe Ser Asn Gln Asn Tyr Pro 
65                  70                  75                  80  


Asp Ile Asp Asp Ala Leu Glu Lys Asn Lys Glu Ile Gln Asp Lys His 
                85                  90                  95      


Leu Thr Gln Thr Val Phe Phe Ser Asn Lys Thr Leu Ile Thr Glu Arg 
            100                 105                 110         


Glu Asn Val Phe Gly Lys Thr Leu Asn Leu Gly Met Asn Ser Val Pro 
        115                 120                 125             


Ser Arg Lys Met Pro Tyr Lys Cys Asn Pro Gly Gly Asn Ser Leu Lys 
    130                 135                 140                 


Thr Asn Ser Glu Val Ile Val Ala Lys Lys Ser Lys Glu Asn Arg Lys 
145                 150                 155                 160 


Ile Pro Asp Gly Tyr Ser Gly Phe Gly Lys His Glu Lys Ser His Leu 
                165                 170                 175     


Gly Met Lys Lys Tyr Arg Tyr Asn Pro Met Arg Lys Ala Ser Asn Gln 
            180                 185                 190         


Asn Glu Asn Leu Ile Leu His Gln Asn Ile Gln Ile Leu Lys Gln Pro 
        195                 200                 205             


Phe Asp Tyr Asn Lys Cys Gly Lys Thr Phe Phe Lys Arg Ala Ile Leu 
    210                 215                 220                 


Ile Thr Gln Lys Gly Arg Gln Thr Glu Arg Lys Pro Asn Glu Cys Asn 
225                 230                 235                 240 


Glu Cys Arg Lys Thr Phe Ser Lys Arg Ser Thr Leu Ile Val His Gln 
                245                 250                 255     


Arg Ile His Thr Gly Glu Lys Pro Tyr Val Cys Ser Asp Cys Arg Lys 
            260                 265                 270         


Thr Phe Arg Val Lys Thr Ser Leu Thr Arg His Arg Arg Ile His Thr 
        275                 280                 285             


Gly Glu Arg Pro Tyr Glu Cys Ser Glu Cys Arg Lys Thr Phe Ile Asp 
    290                 295                 300                 


Lys Ser Ala Leu Ile Val His Gln Lys Ile His Gly Gly Glu Lys Ser 
305                 310                 315                 320 


Tyr Glu Cys Asn Glu Cys Gly Lys Thr Phe Phe Arg Lys Ser Ala Leu 
                325                 330                 335     


Ala Glu His Phe Arg Ser His Thr Gly Glu Lys Pro Tyr Glu Cys Lys 
            340                 345                 350         


Glu Cys Gly Asn Ala Phe Ser Lys Lys Ser Tyr Leu Val Val His Gln 
        355                 360                 365             


Arg Thr His Arg Gly Glu Lys Pro Asn Glu Cys Lys Glu Cys Gly Lys 
    370                 375                 380                 


Thr Phe Phe Cys Gln Ser Ala Leu Thr Ala His Gln Arg Ile His Thr 
385                 390                 395                 400 


Gly Glu Lys Pro Tyr Glu Cys Ser Glu Cys Glu Lys Thr Phe Phe Cys 
                405                 410                 415     


Gln Ser Ala Leu Asn Val His Arg Arg Ser His Thr Gly Glu Lys Pro 
            420                 425                 430         


Tyr Glu Cys Ser Gln Cys Gly Lys Phe Leu Cys Thr Lys Ser Ala Leu 
        435                 440                 445             


Ile Ala His Gln Ile Thr His Arg Gly Lys Lys Ser Tyr Glu Cys Asn 
    450                 455                 460                 


Glu Cys Gly Lys Phe Phe Cys His Lys Ser Thr Leu Thr Ile His Gln 
465                 470                 475                 480 


Arg Thr His Thr Gly Glu Lys His Gly Val Phe Asn Lys Cys Gly Arg 
                485                 490                 495     


Ile Ser Ile Val Lys Ser Asn Cys Ser Gln Cys Lys Arg Met Asn Thr 
            500                 505                 510         


Lys Glu Asn Leu Tyr Glu Cys Ser Glu His Gly His Ala Val Ser Lys 
        515                 520                 525             


Asn Ser His Leu Ile Val His Gln Arg Thr Ile Trp Glu Arg Pro Tyr 
    530                 535                 540                 


Glu Cys Asn Glu Cys Gly Arg Thr Tyr Cys Arg Lys Ser Ala Leu Thr 
545                 550                 555                 560 


His His Gln Arg Thr His Thr Gly Gln Arg Pro Tyr Glu Cys Asn Glu 
                565                 570                 575     


Cys Gly Lys Thr Phe Cys Gln Lys Phe Ser Phe Val Glu His Gln Arg 
            580                 585                 590         


Thr His Thr Gly Glu Lys Pro Tyr Glu Cys Asn Glu Cys Gly Lys Ser 
        595                 600                 605             


Phe Cys His Lys Ser Ala Phe Arg Val His Arg Arg Ile His Thr Gly 
    610                 615                 620                 


Glu Lys Pro Tyr Glu Cys Asn Gln Cys Gly Lys Thr Tyr Arg Arg Leu 
625                 630                 635                 640 


Trp Thr Leu Thr Glu His Gln Lys Ile His Thr Gly Glu Lys Pro Tyr 
                645                 650                 655     


Glu Cys Asn Lys Cys Glu Lys Thr Phe Arg His Lys Ser Asn Phe Leu 
            660                 665                 670         


Leu His Gln Lys Ser His Lys Glu 
        675                 680 


<210>  737
<211>  642
<212>  PRT
<213>  Homo sapiens

<400>  737

Met Leu Glu Asn Tyr Ser Asn Leu Val Ser Val Gly Tyr His Val Ser 
1               5                   10                  15      


Lys Pro Asp Val Ile Phe Lys Leu Glu Gln Gly Glu Glu Pro Trp Ile 
            20                  25                  30          


Val Glu Glu Phe Ser Asn Gln Asn Tyr Pro Asp Ile Asp Asp Ala Leu 
        35                  40                  45              


Glu Lys Asn Lys Glu Ile Gln Asp Lys His Leu Thr Gln Thr Val Phe 
    50                  55                  60                  


Phe Ser Asn Lys Thr Leu Ile Thr Glu Arg Glu Asn Val Phe Gly Lys 
65                  70                  75                  80  


Thr Leu Asn Leu Gly Met Asn Ser Val Pro Ser Arg Lys Met Pro Tyr 
                85                  90                  95      


Lys Cys Asn Pro Gly Gly Asn Ser Leu Lys Thr Asn Ser Glu Val Ile 
            100                 105                 110         


Val Ala Lys Lys Ser Lys Glu Asn Arg Lys Ile Pro Asp Gly Tyr Ser 
        115                 120                 125             


Gly Phe Gly Lys His Glu Lys Ser His Leu Gly Met Lys Lys Tyr Arg 
    130                 135                 140                 


Tyr Asn Pro Met Arg Lys Ala Ser Asn Gln Asn Glu Asn Leu Ile Leu 
145                 150                 155                 160 


His Gln Asn Ile Gln Ile Leu Lys Gln Pro Phe Asp Tyr Asn Lys Cys 
                165                 170                 175     


Gly Lys Thr Phe Phe Lys Arg Ala Ile Leu Ile Thr Gln Lys Gly Arg 
            180                 185                 190         


Gln Thr Glu Arg Lys Pro Asn Glu Cys Asn Glu Cys Arg Lys Thr Phe 
        195                 200                 205             


Ser Lys Arg Ser Thr Leu Ile Val His Gln Arg Ile His Thr Gly Glu 
    210                 215                 220                 


Lys Pro Tyr Val Cys Ser Asp Cys Arg Lys Thr Phe Arg Val Lys Thr 
225                 230                 235                 240 


Ser Leu Thr Arg His Arg Arg Ile His Thr Gly Glu Arg Pro Tyr Glu 
                245                 250                 255     


Cys Ser Glu Cys Arg Lys Thr Phe Ile Asp Lys Ser Ala Leu Ile Val 
            260                 265                 270         


His Gln Lys Ile His Gly Gly Glu Lys Ser Tyr Glu Cys Asn Glu Cys 
        275                 280                 285             


Gly Lys Thr Phe Phe Arg Lys Ser Ala Leu Ala Glu His Phe Arg Ser 
    290                 295                 300                 


His Thr Gly Glu Lys Pro Tyr Glu Cys Lys Glu Cys Gly Asn Ala Phe 
305                 310                 315                 320 


Ser Lys Lys Ser Tyr Leu Val Val His Gln Arg Thr His Arg Gly Glu 
                325                 330                 335     


Lys Pro Asn Glu Cys Lys Glu Cys Gly Lys Thr Phe Phe Cys Gln Ser 
            340                 345                 350         


Ala Leu Thr Ala His Gln Arg Ile His Thr Gly Glu Lys Pro Tyr Glu 
        355                 360                 365             


Cys Ser Glu Cys Glu Lys Thr Phe Phe Cys Gln Ser Ala Leu Asn Val 
    370                 375                 380                 


His Arg Arg Ser His Thr Gly Glu Lys Pro Tyr Glu Cys Ser Gln Cys 
385                 390                 395                 400 


Gly Lys Phe Leu Cys Thr Lys Ser Ala Leu Ile Ala His Gln Ile Thr 
                405                 410                 415     


His Arg Gly Lys Lys Ser Tyr Glu Cys Asn Glu Cys Gly Lys Phe Phe 
            420                 425                 430         


Cys His Lys Ser Thr Leu Thr Ile His Gln Arg Thr His Thr Gly Glu 
        435                 440                 445             


Lys His Gly Val Phe Asn Lys Cys Gly Arg Ile Ser Ile Val Lys Ser 
    450                 455                 460                 


Asn Cys Ser Gln Cys Lys Arg Met Asn Thr Lys Glu Asn Leu Tyr Glu 
465                 470                 475                 480 


Cys Ser Glu His Gly His Ala Val Ser Lys Asn Ser His Leu Ile Val 
                485                 490                 495     


His Gln Arg Thr Ile Trp Glu Arg Pro Tyr Glu Cys Asn Glu Cys Gly 
            500                 505                 510         


Arg Thr Tyr Cys Arg Lys Ser Ala Leu Thr His His Gln Arg Thr His 
        515                 520                 525             


Thr Gly Gln Arg Pro Tyr Glu Cys Asn Glu Cys Gly Lys Thr Phe Cys 
    530                 535                 540                 


Gln Lys Phe Ser Phe Val Glu His Gln Arg Thr His Thr Gly Glu Lys 
545                 550                 555                 560 


Pro Tyr Glu Cys Asn Glu Cys Gly Lys Ser Phe Cys His Lys Ser Ala 
                565                 570                 575     


Phe Arg Val His Arg Arg Ile His Thr Gly Glu Lys Pro Tyr Glu Cys 
            580                 585                 590         


Asn Gln Cys Gly Lys Thr Tyr Arg Arg Leu Trp Thr Leu Thr Glu His 
        595                 600                 605             


Gln Lys Ile His Thr Gly Glu Lys Pro Tyr Glu Cys Asn Lys Cys Glu 
    610                 615                 620                 


Lys Thr Phe Arg His Lys Ser Asn Phe Leu Leu His Gln Lys Ser His 
625                 630                 635                 640 


Lys Glu 
        


<210>  738
<211>  703
<212>  PRT
<213>  Homo sapiens

<400>  738

Met Cys Val Phe Leu His Leu Leu Ser Tyr Ile Lys Asp Thr Ser Phe 
1               5                   10                  15      


Ile Pro Gly Pro Asp Cys Glu Leu His Pro Arg Gly Met Ala Ala Thr 
            20                  25                  30          


Gly Pro Cys Ser Glu Ala Pro Val Gln Gly Cys Asp Ala Gly Glu Leu 
        35                  40                  45              


Gln Gln Leu Gly Leu Cys Gly Val Ser Asp Val Gln Arg Ser Trp Ser 
    50                  55                  60                  


Lys Phe Cys Asn Phe Pro Leu Thr Gly Tyr His Val Ser Lys Pro Asp 
65                  70                  75                  80  


Val Ile Phe Lys Leu Glu Gln Gly Glu Glu Pro Trp Ile Val Glu Glu 
                85                  90                  95      


Phe Ser Asn Gln Asn Tyr Pro Asp Ile Asp Asp Ala Leu Glu Lys Asn 
            100                 105                 110         


Lys Glu Ile Gln Asp Lys His Leu Thr Gln Thr Val Phe Phe Ser Asn 
        115                 120                 125             


Lys Thr Leu Ile Thr Glu Arg Glu Asn Val Phe Gly Lys Thr Leu Asn 
    130                 135                 140                 


Leu Gly Met Asn Ser Val Pro Ser Arg Lys Met Pro Tyr Lys Cys Asn 
145                 150                 155                 160 


Pro Gly Gly Asn Ser Leu Lys Thr Asn Ser Glu Val Ile Val Ala Lys 
                165                 170                 175     


Lys Ser Lys Glu Asn Arg Lys Ile Pro Asp Gly Tyr Ser Gly Phe Gly 
            180                 185                 190         


Lys His Glu Lys Ser His Leu Gly Met Lys Lys Tyr Arg Tyr Asn Pro 
        195                 200                 205             


Met Arg Lys Ala Ser Asn Gln Asn Glu Asn Leu Ile Leu His Gln Asn 
    210                 215                 220                 


Ile Gln Ile Leu Lys Gln Pro Phe Asp Tyr Asn Lys Cys Gly Lys Thr 
225                 230                 235                 240 


Phe Phe Lys Arg Ala Ile Leu Ile Thr Gln Lys Gly Arg Gln Thr Glu 
                245                 250                 255     


Arg Lys Pro Asn Glu Cys Asn Glu Cys Arg Lys Thr Phe Ser Lys Arg 
            260                 265                 270         


Ser Thr Leu Ile Val His Gln Arg Ile His Thr Gly Glu Lys Pro Tyr 
        275                 280                 285             


Val Cys Ser Asp Cys Arg Lys Thr Phe Arg Val Lys Thr Ser Leu Thr 
    290                 295                 300                 


Arg His Arg Arg Ile His Thr Gly Glu Arg Pro Tyr Glu Cys Ser Glu 
305                 310                 315                 320 


Cys Arg Lys Thr Phe Ile Asp Lys Ser Ala Leu Ile Val His Gln Lys 
                325                 330                 335     


Ile His Gly Gly Glu Lys Ser Tyr Glu Cys Asn Glu Cys Gly Lys Thr 
            340                 345                 350         


Phe Phe Arg Lys Ser Ala Leu Ala Glu His Phe Arg Ser His Thr Gly 
        355                 360                 365             


Glu Lys Pro Tyr Glu Cys Lys Glu Cys Gly Asn Ala Phe Ser Lys Lys 
    370                 375                 380                 


Ser Tyr Leu Val Val His Gln Arg Thr His Arg Gly Glu Lys Pro Asn 
385                 390                 395                 400 


Glu Cys Lys Glu Cys Gly Lys Thr Phe Phe Cys Gln Ser Ala Leu Thr 
                405                 410                 415     


Ala His Gln Arg Ile His Thr Gly Glu Lys Pro Tyr Glu Cys Ser Glu 
            420                 425                 430         


Cys Glu Lys Thr Phe Phe Cys Gln Ser Ala Leu Asn Val His Arg Arg 
        435                 440                 445             


Ser His Thr Gly Glu Lys Pro Tyr Glu Cys Ser Gln Cys Gly Lys Phe 
    450                 455                 460                 


Leu Cys Thr Lys Ser Ala Leu Ile Ala His Gln Ile Thr His Arg Gly 
465                 470                 475                 480 


Lys Lys Ser Tyr Glu Cys Asn Glu Cys Gly Lys Phe Phe Cys His Lys 
                485                 490                 495     


Ser Thr Leu Thr Ile His Gln Arg Thr His Thr Gly Glu Lys His Gly 
            500                 505                 510         


Val Phe Asn Lys Cys Gly Arg Ile Ser Ile Val Lys Ser Asn Cys Ser 
        515                 520                 525             


Gln Cys Lys Arg Met Asn Thr Lys Glu Asn Leu Tyr Glu Cys Ser Glu 
    530                 535                 540                 


His Gly His Ala Val Ser Lys Asn Ser His Leu Ile Val His Gln Arg 
545                 550                 555                 560 


Thr Ile Trp Glu Arg Pro Tyr Glu Cys Asn Glu Cys Gly Arg Thr Tyr 
                565                 570                 575     


Cys Arg Lys Ser Ala Leu Thr His His Gln Arg Thr His Thr Gly Gln 
            580                 585                 590         


Arg Pro Tyr Glu Cys Asn Glu Cys Gly Lys Thr Phe Cys Gln Lys Phe 
        595                 600                 605             


Ser Phe Val Glu His Gln Arg Thr His Thr Gly Glu Lys Pro Tyr Glu 
    610                 615                 620                 


Cys Asn Glu Cys Gly Lys Ser Phe Cys His Lys Ser Ala Phe Arg Val 
625                 630                 635                 640 


His Arg Arg Ile His Thr Gly Glu Lys Pro Tyr Glu Cys Asn Gln Cys 
                645                 650                 655     


Gly Lys Thr Tyr Arg Arg Leu Trp Thr Leu Thr Glu His Gln Lys Ile 
            660                 665                 670         


His Thr Gly Glu Lys Pro Tyr Glu Cys Asn Lys Cys Glu Lys Thr Phe 
        675                 680                 685             


Arg His Lys Ser Asn Phe Leu Leu His Gln Lys Ser His Lys Glu 
    690                 695                 700             


<210>  739
<211>  679
<212>  PRT
<213>  Homo sapiens

<400>  739

Met Glu Asn Glu Lys Glu Ile Pro Val Ser Phe Gln Asp Leu Thr Val 
1               5                   10                  15      


Asn Phe Thr Gln Glu Glu Trp Gln Gln Leu Asp Pro Ala Gln Arg Leu 
            20                  25                  30          


Leu Tyr Arg Asp Val Met Leu Glu Asn Tyr Ser Asn Leu Val Ser Val 
        35                  40                  45              


Gly Tyr His Val Ser Lys Pro Asp Val Ile Phe Lys Leu Glu Gln Gly 
    50                  55                  60                  


Glu Glu Pro Trp Ile Val Glu Glu Phe Ser Asn Gln Asn Tyr Pro Asp 
65                  70                  75                  80  


Ile Asp Asp Ala Leu Glu Lys Asn Lys Glu Ile Gln Asp Lys His Leu 
                85                  90                  95      


Thr Gln Thr Val Phe Phe Ser Asn Lys Thr Leu Ile Thr Glu Arg Glu 
            100                 105                 110         


Asn Val Phe Gly Lys Thr Leu Asn Leu Gly Met Asn Ser Val Pro Ser 
        115                 120                 125             


Arg Lys Met Pro Tyr Lys Cys Asn Pro Gly Gly Asn Ser Leu Lys Thr 
    130                 135                 140                 


Asn Ser Glu Val Ile Val Ala Lys Lys Ser Lys Glu Asn Arg Lys Ile 
145                 150                 155                 160 


Pro Asp Gly Tyr Ser Gly Phe Gly Lys His Glu Lys Ser His Leu Gly 
                165                 170                 175     


Met Lys Lys Tyr Arg Tyr Asn Pro Met Arg Lys Ala Ser Asn Gln Asn 
            180                 185                 190         


Glu Asn Leu Ile Leu His Gln Asn Ile Gln Ile Leu Lys Gln Pro Phe 
        195                 200                 205             


Asp Tyr Asn Lys Cys Gly Lys Thr Phe Phe Lys Arg Ala Ile Leu Ile 
    210                 215                 220                 


Thr Gln Lys Gly Arg Gln Thr Glu Arg Lys Pro Asn Glu Cys Asn Glu 
225                 230                 235                 240 


Cys Arg Lys Thr Phe Ser Lys Arg Ser Thr Leu Ile Val His Gln Arg 
                245                 250                 255     


Ile His Thr Gly Glu Lys Pro Tyr Val Cys Ser Asp Cys Arg Lys Thr 
            260                 265                 270         


Phe Arg Val Lys Thr Ser Leu Thr Arg His Arg Arg Ile His Thr Gly 
        275                 280                 285             


Glu Arg Pro Tyr Glu Cys Ser Glu Cys Arg Lys Thr Phe Ile Asp Lys 
    290                 295                 300                 


Ser Ala Leu Ile Val His Gln Lys Ile His Gly Gly Glu Lys Ser Tyr 
305                 310                 315                 320 


Glu Cys Asn Glu Cys Gly Lys Thr Phe Phe Arg Lys Ser Ala Leu Ala 
                325                 330                 335     


Glu His Phe Arg Ser His Thr Gly Glu Lys Pro Tyr Glu Cys Lys Glu 
            340                 345                 350         


Cys Gly Asn Ala Phe Ser Lys Lys Ser Tyr Leu Val Val His Gln Arg 
        355                 360                 365             


Thr His Arg Gly Glu Lys Pro Asn Glu Cys Lys Glu Cys Gly Lys Thr 
    370                 375                 380                 


Phe Phe Cys Gln Ser Ala Leu Thr Ala His Gln Arg Ile His Thr Gly 
385                 390                 395                 400 


Glu Lys Pro Tyr Glu Cys Ser Glu Cys Glu Lys Thr Phe Phe Cys Gln 
                405                 410                 415     


Ser Ala Leu Asn Val His Arg Arg Ser His Thr Gly Glu Lys Pro Tyr 
            420                 425                 430         


Glu Cys Ser Gln Cys Gly Lys Phe Leu Cys Thr Lys Ser Ala Leu Ile 
        435                 440                 445             


Ala His Gln Ile Thr His Arg Gly Lys Lys Ser Tyr Glu Cys Asn Glu 
    450                 455                 460                 


Cys Gly Lys Phe Phe Cys His Lys Ser Thr Leu Thr Ile His Gln Arg 
465                 470                 475                 480 


Thr His Thr Gly Glu Lys His Gly Val Phe Asn Lys Cys Gly Arg Ile 
                485                 490                 495     


Ser Ile Val Lys Ser Asn Cys Ser Gln Cys Lys Arg Met Asn Thr Lys 
            500                 505                 510         


Glu Asn Leu Tyr Glu Cys Ser Glu His Gly His Ala Val Ser Lys Asn 
        515                 520                 525             


Ser His Leu Ile Val His Gln Arg Thr Ile Trp Glu Arg Pro Tyr Glu 
    530                 535                 540                 


Cys Asn Glu Cys Gly Arg Thr Tyr Cys Arg Lys Ser Ala Leu Thr His 
545                 550                 555                 560 


His Gln Arg Thr His Thr Gly Gln Arg Pro Tyr Glu Cys Asn Glu Cys 
                565                 570                 575     


Gly Lys Thr Phe Cys Gln Lys Phe Ser Phe Val Glu His Gln Arg Thr 
            580                 585                 590         


His Thr Gly Glu Lys Pro Tyr Glu Cys Asn Glu Cys Gly Lys Ser Phe 
        595                 600                 605             


Cys His Lys Ser Ala Phe Arg Val His Arg Arg Ile His Thr Gly Glu 
    610                 615                 620                 


Lys Pro Tyr Glu Cys Asn Gln Cys Gly Lys Thr Tyr Arg Arg Leu Trp 
625                 630                 635                 640 


Thr Leu Thr Glu His Gln Lys Ile His Thr Gly Glu Lys Pro Tyr Glu 
                645                 650                 655     


Cys Asn Lys Cys Glu Lys Thr Phe Arg His Lys Ser Asn Phe Leu Leu 
            660                 665                 670         


His Gln Lys Ser His Lys Glu 
        675                 


<210>  740
<211>  173
<212>  PRT
<213>  Homo sapiens

<400>  740

Met Leu Glu Asn Tyr Ser Asn Leu Val Ser Val Gly Tyr His Val Ser 
1               5                   10                  15      


Lys Pro Asp Val Ile Phe Lys Leu Glu Gln Gly Glu Glu Pro Trp Ile 
            20                  25                  30          


Val Glu Glu Phe Ser Asn Gln Asn Tyr Pro Asp Ile Asp Asp Ala Leu 
        35                  40                  45              


Glu Lys Asn Lys Glu Ile Gln Asp Lys His Leu Thr Gln Thr Val Phe 
    50                  55                  60                  


Phe Ser Asn Lys Thr Leu Ile Thr Glu Arg Glu Asn Val Phe Gly Lys 
65                  70                  75                  80  


Thr Leu Asn Leu Gly Met Asn Ser Val Pro Ser Arg Lys Met Pro Tyr 
                85                  90                  95      


Lys Cys Asn Pro Gly Gly Asn Ser Leu Lys Thr Asn Ser Glu Val Ile 
            100                 105                 110         


Val Ala Lys Lys Ser Lys Glu Asn Arg Lys Ile Pro Asp Gly Tyr Ser 
        115                 120                 125             


Gly Phe Gly Lys His Glu Lys Ser His Leu Gly Met Lys Lys Tyr Arg 
    130                 135                 140                 


Tyr Asn Pro Met Arg Lys Ala Ser Asn Gln Asn Glu Asn Leu Ile Leu 
145                 150                 155                 160 


His Gln Asn Ile Gln Ile Leu Lys Gln Pro Phe Asp Tyr 
                165                 170             


<210>  741
<211>  679
<212>  PRT
<213>  Homo sapiens

<400>  741

Met Glu Asn Glu Lys Glu Ile Pro Val Ser Phe Gln Asp Leu Thr Val 
1               5                   10                  15      


Asn Phe Thr Gln Glu Glu Trp Gln Gln Leu Asp Pro Ala Gln Arg Leu 
            20                  25                  30          


Leu Tyr Arg Asp Val Met Leu Glu Asn Tyr Ser Asn Leu Val Ser Val 
        35                  40                  45              


Gly Tyr His Val Ser Lys Pro Asp Val Ile Phe Lys Leu Glu Gln Gly 
    50                  55                  60                  


Glu Glu Pro Trp Ile Val Glu Glu Phe Ser Asn Gln Asn Tyr Pro Asp 
65                  70                  75                  80  


Ile Asp Asp Ala Leu Glu Lys Asn Lys Glu Ile Gln Asp Lys His Leu 
                85                  90                  95      


Thr Gln Thr Val Phe Phe Ser Asn Lys Thr Leu Ile Thr Glu Arg Glu 
            100                 105                 110         


Asn Val Phe Gly Lys Thr Leu Asn Leu Gly Met Asn Ser Val Pro Ser 
        115                 120                 125             


Arg Lys Met Pro Tyr Lys Cys Asn Pro Gly Gly Asn Ser Leu Lys Thr 
    130                 135                 140                 


Asn Ser Glu Val Ile Val Ala Lys Lys Ser Lys Glu Asn Arg Lys Ile 
145                 150                 155                 160 


Pro Asp Gly Tyr Ser Gly Phe Gly Lys His Glu Lys Ser His Leu Gly 
                165                 170                 175     


Met Lys Lys Tyr Arg Tyr Asn Pro Met Arg Lys Ala Ser Asn Gln Asn 
            180                 185                 190         


Glu Asn Leu Ile Leu His Gln Asn Ile Gln Ile Leu Lys Gln Pro Phe 
        195                 200                 205             


Asp Tyr Asn Lys Cys Gly Lys Thr Phe Phe Lys Arg Ala Ile Leu Ile 
    210                 215                 220                 


Thr Gln Lys Gly Arg Gln Thr Glu Arg Lys Pro Asn Glu Cys Asn Glu 
225                 230                 235                 240 


Cys Arg Lys Thr Phe Ser Lys Arg Ser Thr Leu Ile Val His Gln Arg 
                245                 250                 255     


Ile His Thr Gly Glu Lys Pro Tyr Val Cys Ser Asp Cys Arg Lys Thr 
            260                 265                 270         


Phe Arg Val Lys Thr Ser Leu Thr Arg His Arg Arg Ile His Thr Gly 
        275                 280                 285             


Glu Arg Pro Tyr Glu Cys Ser Glu Cys Arg Lys Thr Phe Ile Asp Lys 
    290                 295                 300                 


Ser Ala Leu Ile Val His Gln Lys Ile His Gly Gly Glu Lys Ser Tyr 
305                 310                 315                 320 


Glu Cys Asn Glu Cys Gly Lys Thr Phe Phe Arg Lys Ser Ala Leu Ala 
                325                 330                 335     


Glu His Phe Arg Ser His Thr Gly Glu Lys Pro Tyr Glu Cys Lys Glu 
            340                 345                 350         


Cys Gly Asn Ala Phe Ser Lys Lys Ser Tyr Leu Val Val His Gln Arg 
        355                 360                 365             


Thr His Arg Gly Glu Lys Pro Asn Glu Cys Lys Glu Cys Gly Lys Thr 
    370                 375                 380                 


Phe Phe Cys Gln Ser Ala Leu Thr Ala His Gln Arg Ile His Thr Gly 
385                 390                 395                 400 


Glu Lys Pro Tyr Glu Cys Ser Glu Cys Glu Lys Thr Phe Phe Cys Gln 
                405                 410                 415     


Ser Ala Leu Asn Val His Arg Arg Ser His Thr Gly Glu Lys Pro Tyr 
            420                 425                 430         


Glu Cys Ser Gln Cys Gly Lys Phe Leu Cys Thr Lys Ser Ala Leu Ile 
        435                 440                 445             


Ala His Gln Ile Thr His Arg Gly Lys Lys Ser Tyr Glu Cys Asn Glu 
    450                 455                 460                 


Cys Gly Lys Phe Phe Cys His Lys Ser Thr Leu Thr Ile His Gln Arg 
465                 470                 475                 480 


Thr His Thr Gly Glu Lys His Gly Val Phe Asn Lys Cys Gly Arg Ile 
                485                 490                 495     


Ser Ile Val Lys Ser Asn Cys Ser Gln Cys Lys Arg Met Asn Thr Lys 
            500                 505                 510         


Glu Asn Leu Tyr Glu Cys Ser Glu His Gly His Ala Val Ser Lys Asn 
        515                 520                 525             


Ser His Leu Ile Val His Gln Arg Thr Ile Trp Glu Arg Pro Tyr Glu 
    530                 535                 540                 


Cys Asn Glu Cys Gly Arg Thr Tyr Cys Arg Lys Ser Ala Leu Thr His 
545                 550                 555                 560 


His Gln Arg Thr His Thr Gly Gln Arg Pro Tyr Glu Cys Asn Glu Cys 
                565                 570                 575     


Gly Lys Thr Phe Cys Gln Lys Phe Ser Phe Val Glu His Gln Arg Thr 
            580                 585                 590         


His Thr Gly Glu Lys Pro Tyr Glu Cys Asn Glu Cys Gly Lys Ser Phe 
        595                 600                 605             


Cys His Lys Ser Ala Phe Arg Val His Arg Arg Ile His Thr Gly Glu 
    610                 615                 620                 


Lys Pro Tyr Glu Cys Asn Gln Cys Gly Lys Thr Tyr Arg Arg Leu Trp 
625                 630                 635                 640 


Thr Leu Thr Glu His Gln Lys Ile His Thr Gly Glu Lys Pro Tyr Glu 
                645                 650                 655     


Cys Asn Lys Cys Glu Lys Thr Phe Arg His Lys Ser Asn Phe Leu Leu 
            660                 665                 670         


His Gln Lys Ser His Lys Glu 
        675                 


<210>  742
<211>  1455
<212>  PRT
<213>  Homo sapiens

<400>  742

Met Gly Gly Ala Cys Ser Ser Phe Thr Thr Ser Ser Ser Pro Thr Ile 
1               5                   10                  15      


Tyr Ser Thr Ser Val Thr Asp Ser Lys Ala Met Gln Val Glu Ser Cys 
            20                  25                  30          


Ser Ser Ala Val Gly Val Ser Asn Arg Gly Val Ser Glu Lys Gln Leu 
        35                  40                  45              


Thr Ser Asn Thr Val Gln Gln His Pro Ser Thr Pro Lys Arg His Thr 
    50                  55                  60                  


Val Leu Tyr Ile Ser Pro Pro Pro Glu Asp Leu Leu Asp Asn Ser Arg 
65                  70                  75                  80  


Met Ser Cys Gln Asp Glu Gly Cys Gly Leu Glu Ser Glu Gln Ser Cys 
                85                  90                  95      


Ser Met Trp Met Glu Asp Ser Pro Ser Asn Phe Ser Asn Met Ser Thr 
            100                 105                 110         


Ser Ser Tyr Asn Asp Asn Thr Glu Val Pro Arg Lys Ser Arg Lys Arg 
        115                 120                 125             


Asn Pro Lys Gln Arg Pro Gly Val Lys Arg Arg Asp Cys Glu Glu Ser 
    130                 135                 140                 


Asn Met Asp Ile Phe Asp Ala Asp Ser Ala Lys Ala Pro His Tyr Val 
145                 150                 155                 160 


Leu Ser Gln Leu Thr Thr Asp Asn Lys Gly Asn Ser Lys Ala Gly Asn 
                165                 170                 175     


Gly Thr Leu Glu Asn Gln Lys Gly Thr Gly Val Lys Lys Ser Pro Met 
            180                 185                 190         


Leu Cys Gly Gln Tyr Pro Val Lys Ser Glu Gly Lys Glu Leu Lys Ile 
        195                 200                 205             


Val Val Gln Pro Glu Thr Gln His Arg Ala Arg Tyr Leu Thr Glu Gly 
    210                 215                 220                 


Ser Arg Gly Ser Val Lys Asp Arg Thr Gln Gln Gly Phe Pro Thr Val 
225                 230                 235                 240 


Lys Leu Glu Gly His Asn Glu Pro Val Val Leu Gln Val Phe Val Gly 
                245                 250                 255     


Asn Asp Ser Gly Arg Val Lys Pro His Gly Phe Tyr Gln Ala Cys Arg 
            260                 265                 270         


Val Thr Gly Arg Asn Thr Thr Pro Cys Lys Glu Val Asp Ile Glu Gly 
        275                 280                 285             


Thr Thr Val Ile Glu Val Gly Leu Asp Pro Ser Asn Asn Met Thr Leu 
    290                 295                 300                 


Ala Val Asp Cys Val Gly Ile Leu Lys Leu Arg Asn Ala Asp Val Glu 
305                 310                 315                 320 


Ala Arg Ile Gly Ile Ala Gly Ser Lys Lys Lys Ser Thr Arg Ala Arg 
                325                 330                 335     


Leu Val Phe Arg Val Asn Ile Met Arg Lys Asp Gly Ser Thr Leu Thr 
            340                 345                 350         


Leu Gln Thr Pro Ser Ser Pro Ile Leu Cys Thr Gln Pro Ala Gly Val 
        355                 360                 365             


Pro Glu Ile Leu Lys Lys Ser Leu His Ser Cys Ser Val Lys Gly Glu 
    370                 375                 380                 


Glu Glu Val Phe Leu Ile Gly Lys Asn Phe Leu Lys Gly Thr Lys Val 
385                 390                 395                 400 


Ile Phe Gln Glu Asn Val Ser Asp Glu Asn Ser Trp Lys Ser Glu Ala 
                405                 410                 415     


Glu Ile Asp Met Glu Leu Phe His Gln Asn His Leu Ile Val Lys Val 
            420                 425                 430         


Pro Pro Tyr His Asp Gln His Ile Thr Leu Pro Val Ser Val Gly Ile 
        435                 440                 445             


Tyr Val Val Thr Asn Ala Gly Arg Ser His Asp Val Gln Pro Phe Thr 
    450                 455                 460                 


Tyr Thr Pro Asp Pro Ala Ala Ala Gly Ala Leu Asn Val Asn Val Lys 
465                 470                 475                 480 


Lys Glu Ile Ser Ser Pro Ala Arg Pro Cys Ser Phe Glu Glu Ala Met 
                485                 490                 495     


Lys Ala Met Lys Thr Thr Gly Cys Asn Leu Asp Lys Val Asn Ile Ile 
            500                 505                 510         


Pro Asn Ala Leu Met Thr Pro Leu Ile Pro Ser Ser Met Ile Lys Ser 
        515                 520                 525             


Glu Asp Val Thr Pro Met Glu Val Thr Ala Glu Lys Arg Ser Ser Thr 
    530                 535                 540                 


Ile Phe Lys Thr Thr Lys Ser Val Gly Ser Thr Gln Gln Thr Leu Glu 
545                 550                 555                 560 


Asn Ile Ser Asn Ile Ala Gly Asn Gly Ser Phe Ser Ser Pro Ser Ser 
                565                 570                 575     


Ser His Leu Pro Ser Glu Asn Glu Lys Gln Gln Gln Ile Gln Pro Lys 
            580                 585                 590         


Ala Tyr Asn Pro Glu Thr Leu Thr Thr Ile Gln Thr Gln Asp Ile Ser 
        595                 600                 605             


Gln Pro Gly Thr Phe Pro Ala Val Ser Ala Ser Ser Gln Leu Pro Asn 
    610                 615                 620                 


Ser Asp Ala Leu Leu Gln Gln Ala Thr Gln Phe Gln Thr Arg Glu Thr 
625                 630                 635                 640 


Gln Ser Arg Glu Ile Leu Gln Ser Asp Gly Thr Val Val Asn Leu Ser 
                645                 650                 655     


Gln Leu Thr Glu Ala Ser Gln Gln Gln Gln Gln Ser Pro Leu Gln Glu 
            660                 665                 670         


Gln Ala Gln Thr Leu Gln Gln Gln Ile Ser Ser Asn Ile Phe Pro Ser 
        675                 680                 685             


Pro Asn Ser Val Ser Gln Leu Gln Asn Thr Ile Gln Gln Leu Gln Ala 
    690                 695                 700                 


Gly Ser Phe Thr Gly Ser Thr Ala Ser Gly Ser Ser Gly Ser Val Asp 
705                 710                 715                 720 


Leu Val Gln Gln Val Leu Glu Ala Gln Gln Gln Leu Ser Ser Val Leu 
                725                 730                 735     


Phe Ser Ala Pro Asp Gly Asn Glu Asn Val Gln Glu Gln Leu Ser Ala 
            740                 745                 750         


Asp Ile Phe Gln Gln Val Ser Gln Ile Gln Ser Gly Val Ser Pro Gly 
        755                 760                 765             


Met Phe Ser Ser Thr Glu Pro Thr Val His Thr Arg Pro Asp Asn Leu 
    770                 775                 780                 


Leu Pro Gly Arg Ala Glu Ser Val His Pro Gln Ser Glu Asn Thr Leu 
785                 790                 795                 800 


Ser Asn Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Val Met Glu Ser 
                805                 810                 815     


Ser Ala Ala Met Val Met Glu Met Gln Gln Ser Ile Cys Gln Ala Ala 
            820                 825                 830         


Ala Gln Ile Gln Ser Glu Leu Phe Pro Ser Thr Ala Ser Ala Asn Gly 
        835                 840                 845             


Asn Leu Gln Gln Ser Pro Val Tyr Gln Gln Thr Ser His Met Met Ser 
    850                 855                 860                 


Ala Leu Ser Thr Asn Glu Asp Met Gln Met Gln Cys Glu Leu Phe Ser 
865                 870                 875                 880 


Ser Pro Pro Ala Val Ser Gly Asn Glu Thr Ser Thr Thr Thr Thr Gln 
                885                 890                 895     


Gln Val Ala Thr Pro Gly Thr Thr Met Phe Gln Thr Ser Ser Ser Gly 
            900                 905                 910         


Asp Gly Glu Glu Thr Gly Thr Gln Ala Lys Gln Ile Gln Asn Ser Val 
        915                 920                 925             


Phe Gln Thr Met Val Gln Met Gln His Ser Gly Asp Asn Gln Pro Gln 
    930                 935                 940                 


Val Asn Leu Phe Ser Ser Thr Lys Ser Met Met Ser Val Gln Asn Ser 
945                 950                 955                 960 


Gly Thr Gln Gln Gln Gly Asn Gly Leu Phe Gln Gln Gly Asn Glu Met 
                965                 970                 975     


Met Ser Leu Gln Ser Gly Asn Phe Leu Gln Gln Ser Ser His Ser Gln 
            980                 985                 990         


Ala Gln Leu Phe His Pro Gln Asn  Pro Ile Ala Asp Ala  Gln Asn Leu 
        995                 1000                 1005             


Ser Gln  Glu Thr Gln Gly Ser  Leu Phe His Ser Pro  Asn Pro Ile 
    1010                 1015                 1020             


Val His  Ser Gln Thr Ser Thr  Thr Ser Ser Glu Gln  Met Gln Pro 
    1025                 1030                 1035             


Pro Met  Phe His Ser Gln Ser  Thr Ile Ala Val Leu  Gln Gly Ser 
    1040                 1045                 1050             


Ser Val  Pro Gln Asp Gln Gln  Ser Thr Asn Ile Phe  Leu Ser Gln 
    1055                 1060                 1065             


Ser Pro  Met Asn Asn Leu Gln  Thr Asn Thr Val Ala  Gln Glu Ala 
    1070                 1075                 1080             


Phe Phe  Ala Ala Pro Asn Ser  Ile Ser Pro Leu Gln  Ser Thr Ser 
    1085                 1090                 1095             


Asn Ser  Glu Gln Gln Ala Ala  Phe Gln Gln Gln Ala  Pro Ile Ser 
    1100                 1105                 1110             


His Ile  Gln Thr Pro Met Leu  Ser Gln Glu Gln Ala  Gln Pro Pro 
    1115                 1120                 1125             


Gln Gln  Gly Leu Phe Gln Pro  Gln Val Ala Leu Gly  Ser Leu Pro 
    1130                 1135                 1140             


Pro Asn  Pro Met Pro Gln Ser  Gln Gln Gly Thr Met  Phe Gln Ser 
    1145                 1150                 1155             


Gln His  Ser Ile Val Ala Met  Gln Ser Asn Ser Pro  Ser Gln Glu 
    1160                 1165                 1170             


Gln Gln  Gln Gln Gln Gln Gln  Gln Gln Gln Gln Gln  Gln Gln Gln 
    1175                 1180                 1185             


Gln Gln  Ser Ile Leu Phe Ser  Asn Gln Asn Thr Met  Ala Thr Met 
    1190                 1195                 1200             


Ala Ser  Pro Lys Gln Pro Pro  Pro Asn Met Ile Phe  Asn Pro Asn 
    1205                 1210                 1215             


Gln Asn  Pro Met Ala Asn Gln  Glu Gln Gln Asn Gln  Ser Ile Phe 
    1220                 1225                 1230             


His Gln  Gln Ser Asn Met Ala  Pro Met Asn Gln Glu  Gln Gln Pro 
    1235                 1240                 1245             


Met Gln  Phe Gln Ser Gln Ser  Thr Val Ser Ser Leu  Gln Asn Pro 
    1250                 1255                 1260             


Gly Pro  Thr Gln Ser Glu Ser  Ser Gln Thr Pro Leu  Phe His Ser 
    1265                 1270                 1275             


Ser Pro  Gln Ile Gln Leu Val  Gln Gly Ser Pro Ser  Ser Gln Glu 
    1280                 1285                 1290             


Gln Gln  Val Thr Leu Phe Leu  Ser Pro Ala Ser Met  Ser Ala Leu 
    1295                 1300                 1305             


Gln Thr  Ser Ile Asn Gln Gln  Asp Met Gln Gln Ser  Pro Leu Tyr 
    1310                 1315                 1320             


Ser Pro  Gln Asn Asn Met Pro  Gly Ile Gln Gly Ala  Thr Ser Ser 
    1325                 1330                 1335             


Pro Gln  Pro Gln Ala Thr Leu  Phe His Asn Thr Ala  Gly Gly Thr 
    1340                 1345                 1350             


Met Asn  Gln Leu Gln Asn Ser  Pro Gly Ser Ser Gln  Gln Thr Ser 
    1355                 1360                 1365             


Gly Met  Phe Leu Phe Gly Ile  Gln Asn Asn Cys Ser  Gln Leu Leu 
    1370                 1375                 1380             


Thr Ser  Gly Pro Ala Thr Leu  Pro Asp Gln Leu Met  Ala Ile Ser 
    1385                 1390                 1395             


Gln Pro  Gly Gln Pro Gln Asn  Glu Gly Gln Pro Pro  Val Thr Thr 
    1400                 1405                 1410             


Leu Leu  Ser Gln Gln Met Pro  Glu Asn Ser Pro Leu  Ala Ser Ser 
    1415                 1420                 1425             


Ile Asn  Thr Asn Gln Asn Ile  Glu Lys Ile Asp Leu  Leu Val Ser 
    1430                 1435                 1440             


Leu Gln  Asn Gln Gly Asn Asn  Leu Thr Gly Ser Phe  
    1445                 1450                 1455 


<210>  743
<211>  70
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  743

Xaa Ile Ile Pro Thr Leu Pro Ser Asp Lys Leu Ser Lys Ile Gln Thr 
1               5                   10                  15      


Leu Lys Leu Ala Ala Arg Tyr Ile Asp Phe Leu Tyr Gln Val Leu Gln 
            20                  25                  30          


Ser Asp Glu Leu Asp Ser Lys Met Ala Ser Cys Ser Tyr Val Ala His 
        35                  40                  45              


Glu Arg Leu Ser Tyr Ala Phe Ser Val Trp Arg Met Glu Gly Ala Trp 
    50                  55                  60                  


Ser Met Ser Ala Ser His 
65                  70  


<210>  744
<211>  135
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  744

Xaa Pro Ala Gln Gly Lys Arg Gly Lys Lys Ser Ala Gly Cys Gly Gly 
1               5                   10                  15      


Gly Gly Gly Ala Gly Gly Gly Gly Gly Ser Ser Ser Gly Gly Gly Ser 
            20                  25                  30          


Pro Gln Ser Tyr Glu Glu Leu Gln Thr Gln Arg Val Met Ala Asn Val 
        35                  40                  45              


Arg Glu Arg Gln Arg Thr Gln Ser Leu Asn Glu Ala Phe Ala Ala Leu 
    50                  55                  60                  


Arg Lys Ile Ile Pro Thr Leu Pro Ser Asp Lys Leu Ser Lys Ile Gln 
65                  70                  75                  80  


Thr Leu Lys Leu Ala Ala Arg Tyr Ile Asp Phe Leu Tyr Gln Val Leu 
                85                  90                  95      


Gln Ser Asp Glu Leu Asp Ser Lys Met Ala Ser Cys Ser Tyr Val Ala 
            100                 105                 110         


His Glu Arg Leu Ser Tyr Ala Phe Ser Val Trp Arg Met Glu Gly Ala 
        115                 120                 125             


Trp Ser Met Ser Ala Ser His 
    130                 135 


<210>  745
<211>  202
<212>  PRT
<213>  Homo sapiens

<400>  745

Met Met Gln Asp Val Ser Ser Ser Pro Val Ser Pro Ala Asp Asp Ser 
1               5                   10                  15      


Leu Ser Asn Ser Glu Glu Glu Pro Asp Arg Gln Gln Pro Pro Ser Gly 
            20                  25                  30          


Lys Arg Gly Gly Arg Lys Arg Arg Ser Ser Arg Arg Ser Ala Gly Gly 
        35                  40                  45              


Gly Ala Gly Pro Gly Gly Ala Ala Gly Gly Gly Val Gly Gly Gly Asp 
    50                  55                  60                  


Glu Pro Gly Ser Pro Ala Gln Gly Lys Arg Gly Lys Lys Ser Ala Gly 
65                  70                  75                  80  


Cys Gly Gly Gly Gly Gly Ala Gly Gly Gly Gly Gly Ser Ser Ser Gly 
                85                  90                  95      


Gly Gly Ser Pro Gln Ser Tyr Glu Glu Leu Gln Thr Gln Arg Val Met 
            100                 105                 110         


Ala Asn Val Arg Glu Arg Gln Arg Thr Gln Ser Leu Asn Glu Ala Phe 
        115                 120                 125             


Ala Ala Leu Arg Lys Ile Ile Pro Thr Leu Pro Ser Asp Lys Leu Ser 
    130                 135                 140                 


Lys Ile Gln Thr Leu Lys Leu Ala Ala Arg Tyr Ile Asp Phe Leu Tyr 
145                 150                 155                 160 


Gln Val Leu Gln Ser Asp Glu Leu Asp Ser Lys Met Ala Ser Cys Ser 
                165                 170                 175     


Tyr Val Ala His Glu Arg Leu Ser Tyr Ala Phe Ser Val Trp Arg Met 
            180                 185                 190         


Glu Gly Ala Trp Ser Met Ser Ala Ser His 
        195                 200         


<210>  746
<211>  636
<212>  PRT
<213>  Homo sapiens

<400>  746

Met Ala Gln Ser Thr Ala Thr Ser Pro Asp Gly Gly Thr Thr Phe Glu 
1               5                   10                  15      


His Leu Trp Ser Ser Leu Glu Pro Asp Ser Thr Tyr Phe Asp Leu Pro 
            20                  25                  30          


Gln Ser Ser Arg Gly Asn Asn Glu Val Val Gly Gly Thr Asp Ser Ser 
        35                  40                  45              


Met Asp Val Phe His Leu Glu Gly Met Thr Thr Ser Val Met Ala Gln 
    50                  55                  60                  


Phe Asn Leu Leu Ser Ser Thr Met Asp Gln Met Ser Ser Arg Ala Ala 
65                  70                  75                  80  


Ser Ala Ser Pro Tyr Thr Pro Glu His Ala Ala Ser Val Pro Thr His 
                85                  90                  95      


Ser Pro Tyr Ala Gln Pro Ser Ser Thr Phe Asp Thr Met Ser Pro Ala 
            100                 105                 110         


Pro Val Ile Pro Ser Asn Thr Asp Tyr Pro Gly Pro His His Phe Glu 
        115                 120                 125             


Val Thr Phe Gln Gln Ser Ser Thr Ala Lys Ser Ala Thr Trp Thr Tyr 
    130                 135                 140                 


Ser Pro Leu Leu Lys Lys Leu Tyr Cys Gln Ile Ala Lys Thr Cys Pro 
145                 150                 155                 160 


Ile Gln Ile Lys Val Ser Thr Pro Pro Pro Pro Gly Thr Ala Ile Arg 
                165                 170                 175     


Ala Met Pro Val Tyr Lys Lys Ala Glu His Val Thr Asp Val Val Lys 
            180                 185                 190         


Arg Cys Pro Asn His Glu Leu Gly Arg Asp Phe Asn Glu Gly Gln Ser 
        195                 200                 205             


Ala Pro Ala Ser His Leu Ile Arg Val Glu Gly Asn Asn Leu Ser Gln 
    210                 215                 220                 


Tyr Val Asp Asp Pro Val Thr Gly Arg Gln Ser Val Val Val Pro Tyr 
225                 230                 235                 240 


Glu Pro Pro Gln Val Gly Thr Glu Phe Thr Thr Ile Leu Tyr Asn Phe 
                245                 250                 255     


Met Cys Asn Ser Ser Cys Val Gly Gly Met Asn Arg Arg Pro Ile Leu 
            260                 265                 270         


Ile Ile Ile Thr Leu Glu Met Arg Asp Gly Gln Val Leu Gly Arg Arg 
        275                 280                 285             


Ser Phe Glu Gly Arg Ile Cys Ala Cys Pro Gly Arg Asp Arg Lys Ala 
    290                 295                 300                 


Asp Glu Asp His Tyr Arg Glu Gln Gln Ala Leu Asn Glu Ser Ser Ala 
305                 310                 315                 320 


Lys Asn Gly Ala Ala Ser Lys Arg Ala Phe Lys Gln Ser Pro Pro Ala 
                325                 330                 335     


Val Pro Ala Leu Gly Ala Gly Val Lys Lys Arg Arg His Gly Asp Glu 
            340                 345                 350         


Asp Thr Tyr Tyr Leu Gln Val Arg Gly Arg Glu Asn Phe Glu Ile Leu 
        355                 360                 365             


Met Lys Leu Lys Glu Ser Leu Glu Leu Met Glu Leu Val Pro Gln Pro 
    370                 375                 380                 


Leu Val Asp Ser Tyr Arg Gln Gln Gln Gln Leu Leu Gln Arg Pro Ser 
385                 390                 395                 400 


His Leu Gln Pro Pro Ser Tyr Gly Pro Val Leu Ser Pro Met Asn Lys 
                405                 410                 415     


Val His Gly Gly Met Asn Lys Leu Pro Ser Val Asn Gln Leu Val Gly 
            420                 425                 430         


Gln Pro Pro Pro His Ser Ser Ala Ala Thr Pro Asn Leu Gly Pro Val 
        435                 440                 445             


Gly Pro Gly Met Leu Asn Asn His Gly His Ala Val Pro Ala Asn Gly 
    450                 455                 460                 


Glu Met Ser Ser Ser His Ser Ala Gln Ser Met Val Ser Gly Ser His 
465                 470                 475                 480 


Cys Thr Pro Pro Pro Pro Tyr His Ala Asp Pro Ser Leu Val Ser Phe 
                485                 490                 495     


Leu Thr Gly Leu Gly Cys Pro Asn Cys Ile Glu Tyr Phe Thr Ser Gln 
            500                 505                 510         


Gly Leu Gln Ser Ile Tyr His Leu Gln Asn Leu Thr Ile Glu Asp Leu 
        515                 520                 525             


Gly Ala Leu Lys Ile Pro Glu Gln Tyr Arg Met Thr Ile Trp Arg Gly 
    530                 535                 540                 


Leu Gln Asp Leu Lys Gln Gly His Asp Tyr Ser Thr Ala Gln Gln Leu 
545                 550                 555                 560 


Leu Arg Ser Ser Asn Ala Ala Thr Ile Ser Ile Gly Gly Ser Gly Glu 
                565                 570                 575     


Leu Gln Arg Gln Arg Val Met Glu Ala Val His Phe Arg Val Arg His 
            580                 585                 590         


Thr Ile Thr Ile Pro Asn Arg Gly Gly Pro Gly Gly Gly Pro Asp Glu 
        595                 600                 605             


Trp Ala Asp Phe Gly Phe Asp Leu Pro Asp Cys Lys Ala Arg Lys Gln 
    610                 615                 620                 


Pro Ile Lys Glu Glu Phe Thr Glu Ala Glu Ile His 
625                 630                 635     


<210>  747
<211>  403
<212>  PRT
<213>  Homo sapiens

<400>  747

Met Ala Gln Ser Thr Ala Thr Ser Pro Asp Gly Gly Thr Thr Phe Glu 
1               5                   10                  15      


His Leu Trp Ser Ser Leu Glu Pro Asp Ser Thr Tyr Phe Asp Leu Pro 
            20                  25                  30          


Gln Ser Ser Arg Gly Asn Asn Glu Val Val Gly Gly Thr Asp Ser Ser 
        35                  40                  45              


Met Asp Val Phe His Leu Glu Gly Met Thr Thr Ser Val Met Ala Gln 
    50                  55                  60                  


Phe Asn Leu Leu Ser Ser Thr Met Asp Gln Met Ser Ser Arg Ala Ala 
65                  70                  75                  80  


Ser Ala Ser Pro Tyr Thr Pro Glu His Ala Ala Ser Val Pro Thr His 
                85                  90                  95      


Ser Pro Tyr Ala Gln Pro Ser Ser Thr Phe Asp Thr Met Ser Pro Ala 
            100                 105                 110         


Pro Val Ile Pro Ser Asn Thr Asp Tyr Pro Gly Pro His His Phe Glu 
        115                 120                 125             


Val Thr Phe Gln Gln Ser Ser Thr Ala Lys Ser Ala Thr Trp Thr Tyr 
    130                 135                 140                 


Ser Pro Leu Leu Lys Lys Leu Tyr Cys Gln Ile Ala Lys Thr Cys Pro 
145                 150                 155                 160 


Ile Gln Ile Lys Val Ser Thr Pro Pro Pro Pro Gly Thr Ala Ile Arg 
                165                 170                 175     


Ala Met Pro Val Tyr Lys Lys Ala Glu His Val Thr Asp Val Val Lys 
            180                 185                 190         


Arg Cys Pro Asn His Glu Leu Gly Arg Asp Phe Asn Glu Gly Gln Ser 
        195                 200                 205             


Ala Pro Ala Ser His Leu Ile Arg Val Glu Gly Asn Asn Leu Ser Gln 
    210                 215                 220                 


Tyr Val Asp Asp Pro Val Thr Gly Arg Gln Ser Val Val Val Pro Tyr 
225                 230                 235                 240 


Glu Pro Pro Gln Val Gly Thr Glu Phe Thr Thr Ile Leu Tyr Asn Phe 
                245                 250                 255     


Met Cys Asn Ser Ser Cys Val Gly Gly Met Asn Arg Arg Pro Ile Leu 
            260                 265                 270         


Ile Ile Ile Thr Leu Glu Met Arg Asp Gly Gln Val Leu Gly Arg Arg 
        275                 280                 285             


Ser Phe Glu Gly Arg Ile Cys Ala Cys Pro Gly Arg Asp Arg Lys Ala 
    290                 295                 300                 


Asp Glu Asp His Tyr Arg Glu Gln Gln Ala Leu Asn Glu Ser Ser Ala 
305                 310                 315                 320 


Lys Asn Gly Ala Ala Ser Lys Arg Ala Phe Lys Gln Ser Pro Pro Ala 
                325                 330                 335     


Val Pro Ala Leu Gly Ala Gly Val Lys Lys Arg Arg His Gly Asp Glu 
            340                 345                 350         


Asp Thr Tyr Tyr Leu Gln Val Arg Gly Arg Glu Asn Phe Glu Ile Leu 
        355                 360                 365             


Met Lys Leu Lys Glu Ser Leu Glu Leu Met Glu Leu Val Pro Gln Pro 
    370                 375                 380                 


Leu Val Asp Ser Tyr Arg Gln Gln Gln Gln Leu Leu Gln Arg Pro Thr 
385                 390                 395                 400 


Trp Gly Pro 
            


<210>  748
<211>  499
<212>  PRT
<213>  Homo sapiens

<400>  748

Met Ala Gln Ser Thr Ala Thr Ser Pro Asp Gly Gly Thr Thr Phe Glu 
1               5                   10                  15      


His Leu Trp Ser Ser Leu Glu Pro Asp Ser Thr Tyr Phe Asp Leu Pro 
            20                  25                  30          


Gln Ser Ser Arg Gly Asn Asn Glu Val Val Gly Gly Thr Asp Ser Ser 
        35                  40                  45              


Met Asp Val Phe His Leu Glu Gly Met Thr Thr Ser Val Met Ala Gln 
    50                  55                  60                  


Phe Asn Leu Leu Ser Ser Thr Met Asp Gln Met Ser Ser Arg Ala Ala 
65                  70                  75                  80  


Ser Ala Ser Pro Tyr Thr Pro Glu His Ala Ala Ser Val Pro Thr His 
                85                  90                  95      


Ser Pro Tyr Ala Gln Pro Ser Ser Thr Phe Asp Thr Met Ser Pro Ala 
            100                 105                 110         


Pro Val Ile Pro Ser Asn Thr Asp Tyr Pro Gly Pro His His Phe Glu 
        115                 120                 125             


Val Thr Phe Gln Gln Ser Ser Thr Ala Lys Ser Ala Thr Trp Thr Tyr 
    130                 135                 140                 


Ser Pro Leu Leu Lys Lys Leu Tyr Cys Gln Ile Ala Lys Thr Cys Pro 
145                 150                 155                 160 


Ile Gln Ile Lys Val Ser Thr Pro Pro Pro Pro Gly Thr Ala Ile Arg 
                165                 170                 175     


Ala Met Pro Val Tyr Lys Lys Ala Glu His Val Thr Asp Val Val Lys 
            180                 185                 190         


Arg Cys Pro Asn His Glu Leu Gly Arg Asp Phe Asn Glu Gly Gln Ser 
        195                 200                 205             


Ala Pro Ala Ser His Leu Ile Arg Val Glu Gly Asn Asn Leu Ser Gln 
    210                 215                 220                 


Tyr Val Asp Asp Pro Val Thr Gly Arg Gln Ser Val Val Val Pro Tyr 
225                 230                 235                 240 


Glu Pro Pro Gln Val Gly Thr Glu Phe Thr Thr Ile Leu Tyr Asn Phe 
                245                 250                 255     


Met Cys Asn Ser Ser Cys Val Gly Gly Met Asn Arg Arg Pro Ile Leu 
            260                 265                 270         


Ile Ile Ile Thr Leu Glu Met Arg Asp Gly Gln Val Leu Gly Arg Arg 
        275                 280                 285             


Ser Phe Glu Gly Arg Ile Cys Ala Cys Pro Gly Arg Asp Arg Lys Ala 
    290                 295                 300                 


Asp Glu Asp His Tyr Arg Glu Gln Gln Ala Leu Asn Glu Ser Ser Ala 
305                 310                 315                 320 


Lys Asn Gly Ala Ala Ser Lys Arg Ala Phe Lys Gln Ser Pro Pro Ala 
                325                 330                 335     


Val Pro Ala Leu Gly Ala Gly Val Lys Lys Arg Arg His Gly Asp Glu 
            340                 345                 350         


Asp Thr Tyr Tyr Leu Gln Val Arg Gly Arg Glu Asn Phe Glu Ile Leu 
        355                 360                 365             


Met Lys Leu Lys Glu Ser Leu Glu Leu Met Glu Leu Val Pro Gln Pro 
    370                 375                 380                 


Leu Val Asp Ser Tyr Arg Gln Gln Gln Gln Leu Leu Gln Arg Pro Ser 
385                 390                 395                 400 


His Leu Gln Pro Pro Ser Tyr Gly Pro Val Leu Ser Pro Met Asn Lys 
                405                 410                 415     


Val His Gly Gly Met Asn Lys Leu Pro Ser Val Asn Gln Leu Val Gly 
            420                 425                 430         


Gln Pro Pro Pro His Ser Ser Ala Ala Thr Pro Asn Leu Gly Pro Val 
        435                 440                 445             


Gly Pro Gly Met Leu Asn Asn His Gly His Ala Val Pro Ala Asn Gly 
    450                 455                 460                 


Glu Met Ser Ser Ser His Ser Ala Gln Ser Met Val Ser Gly Ser His 
465                 470                 475                 480 


Cys Thr Pro Pro Pro Pro Tyr His Ala Asp Pro Ser Leu Val Arg Thr 
                485                 490                 495     


Trp Gly Pro 
            


<210>  749
<211>  555
<212>  PRT
<213>  Homo sapiens

<400>  749

Met Ala Gln Ser Thr Ala Thr Ser Pro Asp Gly Gly Thr Thr Phe Glu 
1               5                   10                  15      


His Leu Trp Ser Ser Leu Glu Pro Asp Ser Thr Tyr Phe Asp Leu Pro 
            20                  25                  30          


Gln Ser Ser Arg Gly Asn Asn Glu Val Val Gly Gly Thr Asp Ser Ser 
        35                  40                  45              


Met Asp Val Phe His Leu Glu Gly Met Thr Thr Ser Val Met Ala Gln 
    50                  55                  60                  


Phe Asn Leu Leu Ser Ser Thr Met Asp Gln Met Ser Ser Arg Ala Ala 
65                  70                  75                  80  


Ser Ala Ser Pro Tyr Thr Pro Glu His Ala Ala Ser Val Pro Thr His 
                85                  90                  95      


Ser Pro Tyr Ala Gln Pro Ser Ser Thr Phe Asp Thr Met Ser Pro Ala 
            100                 105                 110         


Pro Val Ile Pro Ser Asn Thr Asp Tyr Pro Gly Pro His His Phe Glu 
        115                 120                 125             


Val Thr Phe Gln Gln Ser Ser Thr Ala Lys Ser Ala Thr Trp Thr Tyr 
    130                 135                 140                 


Ser Pro Leu Leu Lys Lys Leu Tyr Cys Gln Ile Ala Lys Thr Cys Pro 
145                 150                 155                 160 


Ile Gln Ile Lys Val Ser Thr Pro Pro Pro Pro Gly Thr Ala Ile Arg 
                165                 170                 175     


Ala Met Pro Val Tyr Lys Lys Ala Glu His Val Thr Asp Val Val Lys 
            180                 185                 190         


Arg Cys Pro Asn His Glu Leu Gly Arg Asp Phe Asn Glu Gly Gln Ser 
        195                 200                 205             


Ala Pro Ala Ser His Leu Ile Arg Val Glu Gly Asn Asn Leu Ser Gln 
    210                 215                 220                 


Tyr Val Asp Asp Pro Val Thr Gly Arg Gln Ser Val Val Val Pro Tyr 
225                 230                 235                 240 


Glu Pro Pro Gln Val Gly Thr Glu Phe Thr Thr Ile Leu Tyr Asn Phe 
                245                 250                 255     


Met Cys Asn Ser Ser Cys Val Gly Gly Met Asn Arg Arg Pro Ile Leu 
            260                 265                 270         


Ile Ile Ile Thr Leu Glu Met Arg Asp Gly Gln Val Leu Gly Arg Arg 
        275                 280                 285             


Ser Phe Glu Gly Arg Ile Cys Ala Cys Pro Gly Arg Asp Arg Lys Ala 
    290                 295                 300                 


Asp Glu Asp His Tyr Arg Glu Gln Gln Ala Leu Asn Glu Ser Ser Ala 
305                 310                 315                 320 


Lys Asn Gly Ala Ala Ser Lys Arg Ala Phe Lys Gln Ser Pro Pro Ala 
                325                 330                 335     


Val Pro Ala Leu Gly Ala Gly Val Lys Lys Arg Arg His Gly Asp Glu 
            340                 345                 350         


Asp Thr Tyr Tyr Leu Gln Val Arg Gly Arg Glu Asn Phe Glu Ile Leu 
        355                 360                 365             


Met Lys Leu Lys Glu Ser Leu Glu Leu Met Glu Leu Val Pro Gln Pro 
    370                 375                 380                 


Leu Val Asp Ser Tyr Arg Gln Gln Gln Gln Leu Leu Gln Arg Pro Pro 
385                 390                 395                 400 


Arg Asp Ala Gln Gln Pro Trp Pro Arg Ser Ala Ser Gln Arg Arg Asp 
                405                 410                 415     


Glu Gln Gln Pro Gln Arg Pro Val His Gly Leu Gly Val Pro Leu His 
            420                 425                 430         


Ser Ala Thr Pro Leu Pro Arg Arg Pro Gln Pro Arg Gln Asp Leu Gly 
        435                 440                 445             


Ala Leu Lys Ile Pro Glu Gln Tyr Arg Met Thr Ile Trp Arg Gly Leu 
    450                 455                 460                 


Gln Asp Leu Lys Gln Gly His Asp Tyr Ser Thr Ala Gln Gln Leu Leu 
465                 470                 475                 480 


Arg Ser Ser Asn Ala Ala Thr Ile Ser Ile Gly Gly Ser Gly Glu Leu 
                485                 490                 495     


Gln Arg Gln Arg Val Met Glu Ala Val His Phe Arg Val Arg His Thr 
            500                 505                 510         


Ile Thr Ile Pro Asn Arg Gly Gly Pro Gly Gly Gly Pro Asp Glu Trp 
        515                 520                 525             


Ala Asp Phe Gly Phe Asp Leu Pro Asp Cys Lys Ala Arg Lys Gln Pro 
    530                 535                 540                 


Ile Lys Glu Glu Phe Thr Glu Ala Glu Ile His 
545                 550                 555 


<210>  750
<211>  540
<212>  PRT
<213>  Homo sapiens

<400>  750

Met Ala Gln Ser Thr Ala Thr Ser Pro Asp Gly Gly Thr Thr Phe Glu 
1               5                   10                  15      


His Leu Trp Ser Ser Leu Glu Pro Asp Ser Thr Tyr Phe Asp Leu Pro 
            20                  25                  30          


Gln Ser Ser Arg Gly Asn Asn Glu Val Val Gly Gly Thr Asp Ser Ser 
        35                  40                  45              


Met Asp Val Phe His Leu Glu Gly Met Thr Thr Ser Val Met Ala Gln 
    50                  55                  60                  


Phe Asn Leu Leu Ser Ser Thr Met Asp Gln Met Ser Ser Arg Ala Ala 
65                  70                  75                  80  


Ser Ala Ser Pro Tyr Thr Pro Glu His Ala Ala Ser Val Pro Thr His 
                85                  90                  95      


Ser Pro Tyr Ala Gln Pro Ser Ser Thr Phe Asp Thr Met Ser Pro Ala 
            100                 105                 110         


Pro Val Ile Pro Ser Asn Thr Asp Tyr Pro Gly Pro His His Phe Glu 
        115                 120                 125             


Val Thr Phe Gln Gln Ser Ser Thr Ala Lys Ser Ala Thr Trp Thr Tyr 
    130                 135                 140                 


Ser Pro Leu Leu Lys Lys Leu Tyr Cys Gln Ile Ala Lys Thr Cys Pro 
145                 150                 155                 160 


Ile Gln Ile Lys Val Ser Thr Pro Pro Pro Pro Gly Thr Ala Ile Arg 
                165                 170                 175     


Ala Met Pro Val Tyr Lys Lys Ala Glu His Val Thr Asp Val Val Lys 
            180                 185                 190         


Arg Cys Pro Asn His Glu Leu Gly Arg Asp Phe Asn Glu Gly Gln Ser 
        195                 200                 205             


Ala Pro Ala Ser His Leu Ile Arg Val Glu Gly Asn Asn Leu Ser Gln 
    210                 215                 220                 


Tyr Val Asp Asp Pro Val Thr Gly Arg Gln Ser Val Val Val Pro Tyr 
225                 230                 235                 240 


Glu Pro Pro Gln Val Gly Thr Glu Phe Thr Thr Ile Leu Tyr Asn Phe 
                245                 250                 255     


Met Cys Asn Ser Ser Cys Val Gly Gly Met Asn Arg Arg Pro Ile Leu 
            260                 265                 270         


Ile Ile Ile Thr Leu Glu Met Arg Asp Gly Gln Val Leu Gly Arg Arg 
        275                 280                 285             


Ser Phe Glu Gly Arg Ile Cys Ala Cys Pro Gly Arg Asp Arg Lys Ala 
    290                 295                 300                 


Asp Glu Asp His Tyr Arg Glu Gln Gln Ala Leu Asn Glu Ser Ser Ala 
305                 310                 315                 320 


Lys Asn Gly Ala Ala Ser Lys Arg Ala Phe Lys Gln Ser Pro Pro Ala 
                325                 330                 335     


Val Pro Ala Leu Gly Ala Gly Val Lys Lys Arg Arg His Gly Asp Glu 
            340                 345                 350         


Asp Thr Tyr Tyr Leu Gln Val Arg Gly Arg Glu Asn Phe Glu Ile Leu 
        355                 360                 365             


Met Lys Leu Lys Glu Ser Leu Glu Leu Met Glu Leu Val Pro Gln Pro 
    370                 375                 380                 


Leu Val Asp Ser Tyr Arg Gln Gln Gln Gln Leu Leu Gln Arg Pro Phe 
385                 390                 395                 400 


Leu Thr Gly Leu Gly Cys Pro Asn Cys Ile Glu Tyr Phe Thr Ser Gln 
                405                 410                 415     


Gly Leu Gln Ser Ile Tyr His Leu Gln Asn Leu Thr Ile Glu Asp Leu 
            420                 425                 430         


Gly Ala Leu Lys Ile Pro Glu Gln Tyr Arg Met Thr Ile Trp Arg Gly 
        435                 440                 445             


Leu Gln Asp Leu Lys Gln Gly His Asp Tyr Ser Thr Ala Gln Gln Leu 
    450                 455                 460                 


Leu Arg Ser Ser Asn Ala Ala Thr Ile Ser Ile Gly Gly Ser Gly Glu 
465                 470                 475                 480 


Leu Gln Arg Gln Arg Val Met Glu Ala Val His Phe Arg Val Arg His 
                485                 490                 495     


Thr Ile Thr Ile Pro Asn Arg Gly Gly Pro Gly Gly Gly Pro Asp Glu 
            500                 505                 510         


Trp Ala Asp Phe Gly Phe Asp Leu Pro Asp Cys Lys Ala Arg Lys Gln 
        515                 520                 525             


Pro Ile Lys Glu Glu Phe Thr Glu Ala Glu Ile His 
    530                 535                 540 


<210>  751
<211>  450
<212>  PRT
<213>  Homo sapiens

<400>  751

Met Leu Tyr Val Gly Asp Pro Ala Arg His Leu Ala Thr Ala Gln Phe 
1               5                   10                  15      


Asn Leu Leu Ser Ser Thr Met Asp Gln Met Ser Ser Arg Ala Ala Ser 
            20                  25                  30          


Ala Ser Pro Tyr Thr Pro Glu His Ala Ala Ser Val Pro Thr His Ser 
        35                  40                  45              


Pro Tyr Ala Gln Pro Ser Ser Thr Phe Asp Thr Met Ser Pro Ala Pro 
    50                  55                  60                  


Val Ile Pro Ser Asn Thr Asp Tyr Pro Gly Pro His His Phe Glu Val 
65                  70                  75                  80  


Thr Phe Gln Gln Ser Ser Thr Ala Lys Ser Ala Thr Trp Thr Tyr Ser 
                85                  90                  95      


Pro Leu Leu Lys Lys Leu Tyr Cys Gln Ile Ala Lys Thr Cys Pro Ile 
            100                 105                 110         


Gln Ile Lys Val Ser Thr Pro Pro Pro Pro Gly Thr Ala Ile Arg Ala 
        115                 120                 125             


Met Pro Val Tyr Lys Lys Ala Glu His Val Thr Asp Val Val Lys Arg 
    130                 135                 140                 


Cys Pro Asn His Glu Leu Gly Arg Asp Phe Asn Glu Gly Gln Ser Ala 
145                 150                 155                 160 


Pro Ala Ser His Leu Ile Arg Val Glu Gly Asn Asn Leu Ser Gln Tyr 
                165                 170                 175     


Val Asp Asp Pro Val Thr Gly Arg Gln Ser Val Val Val Pro Tyr Glu 
            180                 185                 190         


Pro Pro Gln Val Gly Thr Glu Phe Thr Thr Ile Leu Tyr Asn Phe Met 
        195                 200                 205             


Cys Asn Ser Ser Cys Val Gly Gly Met Asn Arg Arg Pro Ile Leu Ile 
    210                 215                 220                 


Ile Ile Thr Leu Glu Met Arg Asp Gly Gln Val Leu Gly Arg Arg Ser 
225                 230                 235                 240 


Phe Glu Gly Arg Ile Cys Ala Cys Pro Gly Arg Asp Arg Lys Ala Asp 
                245                 250                 255     


Glu Asp His Tyr Arg Glu Gln Gln Ala Leu Asn Glu Ser Ser Ala Lys 
            260                 265                 270         


Asn Gly Ala Ala Ser Lys Arg Ala Phe Lys Gln Ser Pro Pro Ala Val 
        275                 280                 285             


Pro Ala Leu Gly Ala Gly Val Lys Lys Arg Arg His Gly Asp Glu Asp 
    290                 295                 300                 


Thr Tyr Tyr Leu Gln Val Arg Gly Arg Glu Asn Phe Glu Ile Leu Met 
305                 310                 315                 320 


Lys Leu Lys Glu Ser Leu Glu Leu Met Glu Leu Val Pro Gln Pro Leu 
                325                 330                 335     


Val Asp Ser Tyr Arg Gln Gln Gln Gln Leu Leu Gln Arg Pro Ser His 
            340                 345                 350         


Leu Gln Pro Pro Ser Tyr Gly Pro Val Leu Ser Pro Met Asn Lys Val 
        355                 360                 365             


His Gly Gly Met Asn Lys Leu Pro Ser Val Asn Gln Leu Val Gly Gln 
    370                 375                 380                 


Pro Pro Pro His Ser Ser Ala Ala Thr Pro Asn Leu Gly Pro Val Gly 
385                 390                 395                 400 


Pro Gly Met Leu Asn Asn His Gly His Ala Val Pro Ala Asn Gly Glu 
                405                 410                 415     


Met Ser Ser Ser His Ser Ala Gln Ser Met Val Ser Gly Ser His Cys 
            420                 425                 430         


Thr Pro Pro Pro Pro Tyr His Ala Asp Pro Ser Leu Val Arg Thr Trp 
        435                 440                 445             


Gly Pro 
    450 


<210>  752
<211>  426
<212>  PRT
<213>  Homo sapiens

<400>  752

Met Leu Tyr Val Gly Asp Pro Ala Arg His Leu Ala Thr Ala Gln Phe 
1               5                   10                  15      


Asn Leu Leu Ser Ser Thr Met Asp Gln Met Ser Ser Arg Ala Ala Ser 
            20                  25                  30          


Ala Ser Pro Tyr Thr Pro Glu His Ala Ala Ser Val Pro Thr His Ser 
        35                  40                  45              


Pro Tyr Ala Gln Pro Ser Ser Thr Phe Asp Thr Met Ser Pro Ala Pro 
    50                  55                  60                  


Val Ile Pro Ser Asn Thr Asp Tyr Pro Gly Pro His His Phe Glu Val 
65                  70                  75                  80  


Thr Phe Gln Gln Ser Ser Thr Ala Lys Ser Ala Thr Trp Thr Tyr Ser 
                85                  90                  95      


Pro Leu Leu Lys Lys Leu Tyr Cys Gln Ile Ala Lys Thr Cys Pro Ile 
            100                 105                 110         


Gln Ile Lys Val Ser Thr Pro Pro Pro Pro Gly Thr Ala Ile Arg Ala 
        115                 120                 125             


Met Pro Val Tyr Lys Lys Ala Glu His Val Thr Asp Val Val Lys Arg 
    130                 135                 140                 


Cys Pro Asn His Glu Leu Gly Arg Asp Phe Asn Glu Gly Gln Ser Ala 
145                 150                 155                 160 


Pro Ala Ser His Leu Ile Arg Val Glu Gly Asn Asn Leu Ser Gln Tyr 
                165                 170                 175     


Val Asp Asp Pro Val Thr Gly Arg Gln Ser Val Val Val Pro Tyr Glu 
            180                 185                 190         


Pro Pro Gln Val Gly Thr Glu Phe Thr Thr Ile Leu Tyr Asn Phe Met 
        195                 200                 205             


Cys Asn Ser Ser Cys Val Gly Gly Met Asn Arg Arg Pro Ile Leu Ile 
    210                 215                 220                 


Ile Ile Thr Leu Glu Met Arg Asp Gly Gln Val Leu Gly Arg Arg Ser 
225                 230                 235                 240 


Phe Glu Gly Arg Ile Cys Ala Cys Pro Gly Arg Asp Arg Lys Ala Asp 
                245                 250                 255     


Glu Asp His Tyr Arg Glu Gln Gln Ala Leu Asn Glu Ser Ser Ala Lys 
            260                 265                 270         


Asn Gly Ala Ala Ser Lys Arg Ala Phe Lys Gln Ser Pro Pro Ala Val 
        275                 280                 285             


Pro Ala Leu Gly Ala Gly Val Lys Lys Arg Arg His Gly Asp Glu Asp 
    290                 295                 300                 


Thr Tyr Tyr Leu Gln Val Arg Gly Arg Glu Asn Phe Glu Ile Leu Met 
305                 310                 315                 320 


Lys Leu Lys Glu Ser Leu Glu Leu Met Glu Leu Val Pro Gln Pro Leu 
                325                 330                 335     


Val Asp Ser Tyr Arg Gln Gln Gln Gln Leu Leu Gln Arg Pro Pro Arg 
            340                 345                 350         


Asp Ala Gln Gln Pro Trp Pro Arg Ser Ala Ser Gln Arg Arg Asp Glu 
        355                 360                 365             


Gln Gln Pro Gln Arg Pro Val His Gly Leu Gly Val Pro Leu His Ser 
    370                 375                 380                 


Ala Thr Pro Leu Pro Arg Arg Pro Gln Pro Arg Gln Phe Phe Asn Arg 
385                 390                 395                 400 


Ile Gly Val Ser Lys Leu His Arg Val Phe His Leu Pro Arg Val Thr 
                405                 410                 415     


Glu His Leu Pro Pro Ala Glu Pro Asp His 
            420                 425     


<210>  753
<211>  587
<212>  PRT
<213>  Homo sapiens

<400>  753

Met Leu Tyr Val Gly Asp Pro Ala Arg His Leu Ala Thr Ala Gln Phe 
1               5                   10                  15      


Asn Leu Leu Ser Ser Thr Met Asp Gln Met Ser Ser Arg Ala Ala Ser 
            20                  25                  30          


Ala Ser Pro Tyr Thr Pro Glu His Ala Ala Ser Val Pro Thr His Ser 
        35                  40                  45              


Pro Tyr Ala Gln Pro Ser Ser Thr Phe Asp Thr Met Ser Pro Ala Pro 
    50                  55                  60                  


Val Ile Pro Ser Asn Thr Asp Tyr Pro Gly Pro His His Phe Glu Val 
65                  70                  75                  80  


Thr Phe Gln Gln Ser Ser Thr Ala Lys Ser Ala Thr Trp Thr Tyr Ser 
                85                  90                  95      


Pro Leu Leu Lys Lys Leu Tyr Cys Gln Ile Ala Lys Thr Cys Pro Ile 
            100                 105                 110         


Gln Ile Lys Val Ser Thr Pro Pro Pro Pro Gly Thr Ala Ile Arg Ala 
        115                 120                 125             


Met Pro Val Tyr Lys Lys Ala Glu His Val Thr Asp Val Val Lys Arg 
    130                 135                 140                 


Cys Pro Asn His Glu Leu Gly Arg Asp Phe Asn Glu Gly Gln Ser Ala 
145                 150                 155                 160 


Pro Ala Ser His Leu Ile Arg Val Glu Gly Asn Asn Leu Ser Gln Tyr 
                165                 170                 175     


Val Asp Asp Pro Val Thr Gly Arg Gln Ser Val Val Val Pro Tyr Glu 
            180                 185                 190         


Pro Pro Gln Val Gly Thr Glu Phe Thr Thr Ile Leu Tyr Asn Phe Met 
        195                 200                 205             


Cys Asn Ser Ser Cys Val Gly Gly Met Asn Arg Arg Pro Ile Leu Ile 
    210                 215                 220                 


Ile Ile Thr Leu Glu Met Arg Asp Gly Gln Val Leu Gly Arg Arg Ser 
225                 230                 235                 240 


Phe Glu Gly Arg Ile Cys Ala Cys Pro Gly Arg Asp Arg Lys Ala Asp 
                245                 250                 255     


Glu Asp His Tyr Arg Glu Gln Gln Ala Leu Asn Glu Ser Ser Ala Lys 
            260                 265                 270         


Asn Gly Ala Ala Ser Lys Arg Ala Phe Lys Gln Ser Pro Pro Ala Val 
        275                 280                 285             


Pro Ala Leu Gly Ala Gly Val Lys Lys Arg Arg His Gly Asp Glu Asp 
    290                 295                 300                 


Thr Tyr Tyr Leu Gln Val Arg Gly Arg Glu Asn Phe Glu Ile Leu Met 
305                 310                 315                 320 


Lys Leu Lys Glu Ser Leu Glu Leu Met Glu Leu Val Pro Gln Pro Leu 
                325                 330                 335     


Val Asp Ser Tyr Arg Gln Gln Gln Gln Leu Leu Gln Arg Pro Ser His 
            340                 345                 350         


Leu Gln Pro Pro Ser Tyr Gly Pro Val Leu Ser Pro Met Asn Lys Val 
        355                 360                 365             


His Gly Gly Met Asn Lys Leu Pro Ser Val Asn Gln Leu Val Gly Gln 
    370                 375                 380                 


Pro Pro Pro His Ser Ser Ala Ala Thr Pro Asn Leu Gly Pro Val Gly 
385                 390                 395                 400 


Pro Gly Met Leu Asn Asn His Gly His Ala Val Pro Ala Asn Gly Glu 
                405                 410                 415     


Met Ser Ser Ser His Ser Ala Gln Ser Met Val Ser Gly Ser His Cys 
            420                 425                 430         


Thr Pro Pro Pro Pro Tyr His Ala Asp Pro Ser Leu Val Ser Phe Leu 
        435                 440                 445             


Thr Gly Leu Gly Cys Pro Asn Cys Ile Glu Tyr Phe Thr Ser Gln Gly 
    450                 455                 460                 


Leu Gln Ser Ile Tyr His Leu Gln Asn Leu Thr Ile Glu Asp Leu Gly 
465                 470                 475                 480 


Ala Leu Lys Ile Pro Glu Gln Tyr Arg Met Thr Ile Trp Arg Gly Leu 
                485                 490                 495     


Gln Asp Leu Lys Gln Gly His Asp Tyr Ser Thr Ala Gln Gln Leu Leu 
            500                 505                 510         


Arg Ser Ser Asn Ala Ala Thr Ile Ser Ile Gly Gly Ser Gly Glu Leu 
        515                 520                 525             


Gln Arg Gln Arg Val Met Glu Ala Val His Phe Arg Val Arg His Thr 
    530                 535                 540                 


Ile Thr Ile Pro Asn Arg Gly Gly Pro Gly Gly Gly Pro Asp Glu Trp 
545                 550                 555                 560 


Ala Asp Phe Gly Phe Asp Leu Pro Asp Cys Lys Ala Arg Lys Gln Pro 
                565                 570                 575     


Ile Lys Glu Glu Phe Thr Glu Ala Glu Ile His 
            580                 585         


<210>  754
<211>  565
<212>  PRT
<213>  Homo sapiens

<400>  754

Met Asp Gln Met Ser Ser Arg Ala Ala Ser Ala Ser Pro Tyr Thr Pro 
1               5                   10                  15      


Glu His Ala Ala Ser Val Pro Thr His Ser Pro Tyr Ala Gln Pro Ser 
            20                  25                  30          


Ser Thr Phe Asp Thr Met Ser Pro Ala Pro Val Ile Pro Ser Asn Thr 
        35                  40                  45              


Asp Tyr Pro Gly Pro His His Phe Glu Val Thr Phe Gln Gln Ser Ser 
    50                  55                  60                  


Thr Ala Lys Ser Ala Thr Trp Thr Tyr Ser Pro Leu Leu Lys Lys Leu 
65                  70                  75                  80  


Tyr Cys Gln Ile Ala Lys Thr Cys Pro Ile Gln Ile Lys Val Ser Thr 
                85                  90                  95      


Pro Pro Pro Pro Gly Thr Ala Ile Arg Ala Met Pro Val Tyr Lys Lys 
            100                 105                 110         


Ala Glu His Val Thr Asp Val Val Lys Arg Cys Pro Asn His Glu Leu 
        115                 120                 125             


Gly Arg Asp Phe Asn Glu Gly Gln Ser Ala Pro Ala Ser His Leu Ile 
    130                 135                 140                 


Arg Val Glu Gly Asn Asn Leu Ser Gln Tyr Val Asp Asp Pro Val Thr 
145                 150                 155                 160 


Gly Arg Gln Ser Val Val Val Pro Tyr Glu Pro Pro Gln Val Gly Thr 
                165                 170                 175     


Glu Phe Thr Thr Ile Leu Tyr Asn Phe Met Cys Asn Ser Ser Cys Val 
            180                 185                 190         


Gly Gly Met Asn Arg Arg Pro Ile Leu Ile Ile Ile Thr Leu Glu Met 
        195                 200                 205             


Arg Asp Gly Gln Val Leu Gly Arg Arg Ser Phe Glu Gly Arg Ile Cys 
    210                 215                 220                 


Ala Cys Pro Gly Arg Asp Arg Lys Ala Asp Glu Asp His Tyr Arg Glu 
225                 230                 235                 240 


Gln Gln Ala Leu Asn Glu Ser Ser Ala Lys Asn Gly Ala Ala Ser Lys 
                245                 250                 255     


Arg Ala Phe Lys Gln Ser Pro Pro Ala Val Pro Ala Leu Gly Ala Gly 
            260                 265                 270         


Val Lys Lys Arg Arg His Gly Asp Glu Asp Thr Tyr Tyr Leu Gln Val 
        275                 280                 285             


Arg Gly Arg Glu Asn Phe Glu Ile Leu Met Lys Leu Lys Glu Ser Leu 
    290                 295                 300                 


Glu Leu Met Glu Leu Val Pro Gln Pro Leu Val Asp Ser Tyr Arg Gln 
305                 310                 315                 320 


Gln Gln Gln Leu Leu Gln Arg Pro Ser His Leu Gln Pro Pro Ser Tyr 
                325                 330                 335     


Gly Pro Val Leu Ser Pro Met Asn Lys Val His Gly Gly Met Asn Lys 
            340                 345                 350         


Leu Pro Ser Val Asn Gln Leu Val Gly Gln Pro Pro Pro His Ser Ser 
        355                 360                 365             


Ala Ala Thr Pro Asn Leu Gly Pro Val Gly Pro Gly Met Leu Asn Asn 
    370                 375                 380                 


His Gly His Ala Val Pro Ala Asn Gly Glu Met Ser Ser Ser His Ser 
385                 390                 395                 400 


Ala Gln Ser Met Val Ser Gly Ser His Cys Thr Pro Pro Pro Pro Tyr 
                405                 410                 415     


His Ala Asp Pro Ser Leu Val Ser Phe Leu Thr Gly Leu Gly Cys Pro 
            420                 425                 430         


Asn Cys Ile Glu Tyr Phe Thr Ser Gln Gly Leu Gln Ser Ile Tyr His 
        435                 440                 445             


Leu Gln Asn Leu Thr Ile Glu Asp Leu Gly Ala Leu Lys Ile Pro Glu 
    450                 455                 460                 


Gln Tyr Arg Met Thr Ile Trp Arg Gly Leu Gln Asp Leu Lys Gln Gly 
465                 470                 475                 480 


His Asp Tyr Ser Thr Ala Gln Gln Leu Leu Arg Ser Ser Asn Ala Ala 
                485                 490                 495     


Thr Ile Ser Ile Gly Gly Ser Gly Glu Leu Gln Arg Gln Arg Val Met 
            500                 505                 510         


Glu Ala Val His Phe Arg Val Arg His Thr Ile Thr Ile Pro Asn Arg 
        515                 520                 525             


Gly Gly Pro Gly Gly Gly Pro Asp Glu Trp Ala Asp Phe Gly Phe Asp 
    530                 535                 540                 


Leu Pro Asp Cys Lys Ala Arg Lys Gln Pro Ile Lys Glu Glu Phe Thr 
545                 550                 555                 560 


Glu Ala Glu Ile His 
                565 


<210>  755
<211>  555
<212>  PRT
<213>  Homo sapiens

<400>  755

Met Ala Gln Ser Thr Ala Thr Ser Pro Asp Gly Gly Thr Thr Phe Glu 
1               5                   10                  15      


His Leu Trp Ser Ser Leu Glu Pro Asp Ser Thr Tyr Phe Asp Leu Pro 
            20                  25                  30          


Gln Ser Ser Arg Gly Asn Asn Glu Val Val Gly Gly Thr Asp Ser Ser 
        35                  40                  45              


Met Asp Val Phe His Leu Glu Gly Met Thr Thr Ser Val Met Ala Gln 
    50                  55                  60                  


Phe Asn Leu Leu Ser Ser Thr Met Asp Gln Met Ser Ser Arg Ala Ala 
65                  70                  75                  80  


Ser Ala Ser Pro Tyr Thr Pro Glu His Ala Ala Ser Val Pro Thr His 
                85                  90                  95      


Ser Pro Tyr Ala Gln Pro Ser Ser Thr Phe Asp Thr Met Ser Pro Ala 
            100                 105                 110         


Pro Val Ile Pro Ser Asn Thr Asp Tyr Pro Gly Pro His His Phe Glu 
        115                 120                 125             


Val Thr Phe Gln Gln Ser Ser Thr Ala Lys Ser Ala Thr Trp Thr Tyr 
    130                 135                 140                 


Ser Pro Leu Leu Lys Lys Leu Tyr Cys Gln Ile Ala Lys Thr Cys Pro 
145                 150                 155                 160 


Ile Gln Ile Lys Val Ser Thr Pro Pro Pro Pro Gly Thr Ala Ile Arg 
                165                 170                 175     


Ala Met Pro Val Tyr Lys Lys Ala Glu His Val Thr Asp Val Val Lys 
            180                 185                 190         


Arg Cys Pro Asn His Glu Leu Gly Arg Asp Phe Asn Glu Gly Gln Ser 
        195                 200                 205             


Ala Pro Ala Ser His Leu Ile Arg Val Glu Gly Asn Asn Leu Ser Gln 
    210                 215                 220                 


Tyr Val Asp Asp Pro Val Thr Gly Arg Gln Ser Val Val Val Pro Tyr 
225                 230                 235                 240 


Glu Pro Pro Gln Val Gly Thr Glu Phe Thr Thr Ile Leu Tyr Asn Phe 
                245                 250                 255     


Met Cys Asn Ser Ser Cys Val Gly Gly Met Asn Arg Arg Pro Ile Leu 
            260                 265                 270         


Ile Ile Ile Thr Leu Glu Met Arg Asp Gly Gln Val Leu Gly Arg Arg 
        275                 280                 285             


Ser Phe Glu Gly Arg Ile Cys Ala Cys Pro Gly Arg Asp Arg Lys Ala 
    290                 295                 300                 


Asp Glu Asp His Tyr Arg Glu Gln Gln Ala Leu Asn Glu Ser Ser Ala 
305                 310                 315                 320 


Lys Asn Gly Ala Ala Ser Lys Arg Ala Phe Lys Gln Ser Pro Pro Ala 
                325                 330                 335     


Val Pro Ala Leu Gly Ala Gly Val Lys Lys Arg Arg His Gly Asp Glu 
            340                 345                 350         


Asp Thr Tyr Tyr Leu Gln Val Arg Gly Arg Glu Asn Phe Glu Ile Leu 
        355                 360                 365             


Met Lys Leu Lys Glu Ser Leu Glu Leu Met Glu Leu Val Pro Gln Pro 
    370                 375                 380                 


Leu Val Asp Ser Tyr Arg Gln Gln Gln Gln Leu Leu Gln Arg Pro Pro 
385                 390                 395                 400 


Arg Asp Ala Gln Gln Pro Trp Pro Arg Ser Ala Ser Gln Arg Arg Asp 
                405                 410                 415     


Glu Gln Gln Pro Gln Arg Pro Val His Gly Leu Gly Val Pro Leu His 
            420                 425                 430         


Ser Ala Thr Pro Leu Pro Arg Arg Pro Gln Pro Arg Gln Asp Leu Gly 
        435                 440                 445             


Ala Leu Lys Ile Pro Glu Gln Tyr Arg Met Thr Ile Trp Arg Gly Leu 
    450                 455                 460                 


Gln Asp Leu Lys Gln Gly His Asp Tyr Ser Thr Ala Gln Gln Leu Leu 
465                 470                 475                 480 


Arg Ser Ser Asn Ala Ala Thr Ile Ser Ile Gly Gly Ser Gly Glu Leu 
                485                 490                 495     


Gln Arg Gln Arg Val Met Glu Ala Val His Phe Arg Val Arg His Thr 
            500                 505                 510         


Ile Thr Ile Pro Asn Arg Gly Gly Pro Gly Gly Gly Pro Asp Glu Trp 
        515                 520                 525             


Ala Asp Phe Gly Phe Asp Leu Pro Asp Cys Lys Ala Arg Lys Gln Pro 
    530                 535                 540                 


Ile Lys Glu Glu Phe Thr Glu Ala Glu Ile His 
545                 550                 555 


<210>  756
<211>  540
<212>  PRT
<213>  Homo sapiens

<400>  756

Met Ala Gln Ser Thr Ala Thr Ser Pro Asp Gly Gly Thr Thr Phe Glu 
1               5                   10                  15      


His Leu Trp Ser Ser Leu Glu Pro Asp Ser Thr Tyr Phe Asp Leu Pro 
            20                  25                  30          


Gln Ser Ser Arg Gly Asn Asn Glu Val Val Gly Gly Thr Asp Ser Ser 
        35                  40                  45              


Met Asp Val Phe His Leu Glu Gly Met Thr Thr Ser Val Met Ala Gln 
    50                  55                  60                  


Phe Asn Leu Leu Ser Ser Thr Met Asp Gln Met Ser Ser Arg Ala Ala 
65                  70                  75                  80  


Ser Ala Ser Pro Tyr Thr Pro Glu His Ala Ala Ser Val Pro Thr His 
                85                  90                  95      


Ser Pro Tyr Ala Gln Pro Ser Ser Thr Phe Asp Thr Met Ser Pro Ala 
            100                 105                 110         


Pro Val Ile Pro Ser Asn Thr Asp Tyr Pro Gly Pro His His Phe Glu 
        115                 120                 125             


Val Thr Phe Gln Gln Ser Ser Thr Ala Lys Ser Ala Thr Trp Thr Tyr 
    130                 135                 140                 


Ser Pro Leu Leu Lys Lys Leu Tyr Cys Gln Ile Ala Lys Thr Cys Pro 
145                 150                 155                 160 


Ile Gln Ile Lys Val Ser Thr Pro Pro Pro Pro Gly Thr Ala Ile Arg 
                165                 170                 175     


Ala Met Pro Val Tyr Lys Lys Ala Glu His Val Thr Asp Val Val Lys 
            180                 185                 190         


Arg Cys Pro Asn His Glu Leu Gly Arg Asp Phe Asn Glu Gly Gln Ser 
        195                 200                 205             


Ala Pro Ala Ser His Leu Ile Arg Val Glu Gly Asn Asn Leu Ser Gln 
    210                 215                 220                 


Tyr Val Asp Asp Pro Val Thr Gly Arg Gln Ser Val Val Val Pro Tyr 
225                 230                 235                 240 


Glu Pro Pro Gln Val Gly Thr Glu Phe Thr Thr Ile Leu Tyr Asn Phe 
                245                 250                 255     


Met Cys Asn Ser Ser Cys Val Gly Gly Met Asn Arg Arg Pro Ile Leu 
            260                 265                 270         


Ile Ile Ile Thr Leu Glu Met Arg Asp Gly Gln Val Leu Gly Arg Arg 
        275                 280                 285             


Ser Phe Glu Gly Arg Ile Cys Ala Cys Pro Gly Arg Asp Arg Lys Ala 
    290                 295                 300                 


Asp Glu Asp His Tyr Arg Glu Gln Gln Ala Leu Asn Glu Ser Ser Ala 
305                 310                 315                 320 


Lys Asn Gly Ala Ala Ser Lys Arg Ala Phe Lys Gln Ser Pro Pro Ala 
                325                 330                 335     


Val Pro Ala Leu Gly Ala Gly Val Lys Lys Arg Arg His Gly Asp Glu 
            340                 345                 350         


Asp Thr Tyr Tyr Leu Gln Val Arg Gly Arg Glu Asn Phe Glu Ile Leu 
        355                 360                 365             


Met Lys Leu Lys Glu Ser Leu Glu Leu Met Glu Leu Val Pro Gln Pro 
    370                 375                 380                 


Leu Val Asp Ser Tyr Arg Gln Gln Gln Gln Leu Leu Gln Arg Pro Phe 
385                 390                 395                 400 


Leu Thr Gly Leu Gly Cys Pro Asn Cys Ile Glu Tyr Phe Thr Ser Gln 
                405                 410                 415     


Gly Leu Gln Ser Ile Tyr His Leu Gln Asn Leu Thr Ile Glu Asp Leu 
            420                 425                 430         


Gly Ala Leu Lys Ile Pro Glu Gln Tyr Arg Met Thr Ile Trp Arg Gly 
        435                 440                 445             


Leu Gln Asp Leu Lys Gln Gly His Asp Tyr Ser Thr Ala Gln Gln Leu 
    450                 455                 460                 


Leu Arg Ser Ser Asn Ala Ala Thr Ile Ser Ile Gly Gly Ser Gly Glu 
465                 470                 475                 480 


Leu Gln Arg Gln Arg Val Met Glu Ala Val His Phe Arg Val Arg His 
                485                 490                 495     


Thr Ile Thr Ile Pro Asn Arg Gly Gly Pro Gly Gly Gly Pro Asp Glu 
            500                 505                 510         


Trp Ala Asp Phe Gly Phe Asp Leu Pro Asp Cys Lys Ala Arg Lys Gln 
        515                 520                 525             


Pro Ile Lys Glu Glu Phe Thr Glu Ala Glu Ile His 
    530                 535                 540 


<210>  757
<211>  602
<212>  PRT
<213>  Homo sapiens

<400>  757

Met Ala Ala Glu Glu Glu Ala Ala Ala Gly Gly Lys Val Leu Arg Glu 
1               5                   10                  15      


Glu Asn Gln Cys Ile Ala Pro Val Val Ser Ser Arg Val Ser Pro Gly 
            20                  25                  30          


Thr Arg Pro Thr Ala Met Gly Ser Phe Ser Ser His Met Thr Glu Phe 
        35                  40                  45              


Pro Arg Lys Arg Lys Gly Ser Asp Ser Asp Pro Ser Gln Val Glu Asp 
    50                  55                  60                  


Gly Glu His Gln Val Lys Met Lys Ala Phe Arg Glu Ala His Ser Gln 
65                  70                  75                  80  


Thr Glu Lys Arg Arg Arg Asp Lys Met Asn Asn Leu Ile Glu Glu Leu 
                85                  90                  95      


Ser Ala Met Ile Pro Gln Cys Asn Pro Met Ala Arg Lys Leu Asp Lys 
            100                 105                 110         


Leu Thr Val Leu Arg Met Ala Val Gln His Leu Arg Ser Leu Lys Gly 
        115                 120                 125             


Leu Thr Asn Ser Tyr Val Gly Ser Asn Tyr Arg Pro Ser Phe Leu Gln 
    130                 135                 140                 


Asp Asn Glu Leu Arg His Leu Ile Leu Lys Thr Ala Glu Gly Phe Leu 
145                 150                 155                 160 


Phe Val Val Gly Cys Glu Arg Gly Lys Ile Leu Phe Val Ser Lys Ser 
                165                 170                 175     


Val Ser Lys Ile Leu Asn Tyr Asp Gln Ala Ser Leu Thr Gly Gln Ser 
            180                 185                 190         


Leu Phe Asp Phe Leu His Pro Lys Asp Val Ala Lys Val Lys Glu Gln 
        195                 200                 205             


Leu Ser Ser Phe Asp Ile Ser Pro Arg Glu Lys Leu Ile Asp Ala Lys 
    210                 215                 220                 


Thr Gly Leu Gln Val His Ser Asn Leu His Ala Gly Arg Thr Arg Val 
225                 230                 235                 240 


Tyr Ser Gly Ser Arg Arg Ser Phe Phe Cys Arg Ile Lys Ser Cys Lys 
                245                 250                 255     


Ile Ser Val Lys Glu Glu His Gly Cys Leu Pro Asn Ser Lys Lys Lys 
            260                 265                 270         


Glu His Arg Lys Phe Tyr Thr Ile His Cys Thr Gly Tyr Leu Arg Ser 
        275                 280                 285             


Trp Pro Pro Asn Ile Val Gly Met Glu Glu Glu Arg Asn Ser Lys Lys 
    290                 295                 300                 


Asp Asn Ser Asn Phe Thr Cys Leu Val Ala Ile Gly Arg Leu Gln Pro 
305                 310                 315                 320 


Tyr Ile Val Pro Gln Asn Ser Gly Glu Ile Asn Val Lys Pro Thr Glu 
                325                 330                 335     


Phe Ile Thr Arg Phe Ala Val Asn Gly Lys Phe Val Tyr Val Asp Gln 
            340                 345                 350         


Arg Ala Thr Ala Ile Leu Gly Tyr Leu Pro Gln Glu Leu Leu Gly Thr 
        355                 360                 365             


Ser Cys Tyr Glu Tyr Phe His Gln Asp Asp His Asn Asn Leu Thr Asp 
    370                 375                 380                 


Lys His Lys Ala Val Leu Gln Ser Lys Glu Lys Ile Leu Thr Asp Ser 
385                 390                 395                 400 


Tyr Lys Phe Arg Ala Lys Asp Gly Ser Phe Val Thr Leu Lys Ser Gln 
                405                 410                 415     


Trp Phe Ser Phe Thr Asn Pro Trp Thr Lys Glu Leu Glu Tyr Ile Val 
            420                 425                 430         


Ser Val Asn Thr Leu Val Leu Gly His Ser Glu Pro Gly Glu Ala Ser 
        435                 440                 445             


Phe Leu Pro Cys Ser Ser Gln Ser Ser Glu Glu Ser Ser Arg Gln Ser 
    450                 455                 460                 


Cys Met Ser Val Pro Gly Met Ser Thr Gly Thr Val Leu Gly Ala Gly 
465                 470                 475                 480 


Ser Ile Gly Thr Asp Ile Ala Asn Glu Ile Leu Asp Leu Gln Arg Leu 
                485                 490                 495     


Gln Ser Ser Ser Tyr Leu Asp Asp Ser Ser Pro Thr Gly Leu Met Lys 
            500                 505                 510         


Asp Thr His Thr Val Asn Cys Arg Ser Met Ser Asn Lys Glu Leu Phe 
        515                 520                 525             


Pro Pro Ser Pro Ser Glu Met Gly Glu Leu Glu Ala Thr Arg Gln Asn 
    530                 535                 540                 


Gln Ser Thr Val Ala Val His Ser His Glu Pro Leu Leu Ser Asp Gly 
545                 550                 555                 560 


Ala Gln Leu Asp Phe Asp Ala Leu Cys Asp Asn Asp Asp Thr Ala Met 
                565                 570                 575     


Ala Ala Phe Met Asn Tyr Leu Glu Ala Glu Gly Gly Leu Gly Asp Pro 
            580                 585                 590         


Gly Asp Phe Ser Asp Ile Gln Trp Thr Leu 
        595                 600         


<210>  758
<211>  599
<212>  PRT
<213>  Homo sapiens

<400>  758

Met Ala Ala Glu Glu Glu Ala Ala Ala Gly Gly Glu Val Ala Gly Gly 
1               5                   10                  15      


Glu Ala Thr Ala Pro Gly Lys Val Leu Arg Glu Glu Asn Gln Cys Ile 
            20                  25                  30          


Ala Pro Val Val Ser Ser Arg Val Ser Pro Gly Thr Arg Pro Thr Ala 
        35                  40                  45              


Met Gly Ser Phe Ser Ser His Met Thr Glu Phe Pro Arg Lys Arg Lys 
    50                  55                  60                  


Gly Ser Asp Ser Asp Pro Ser Gln Glu Ala His Ser Gln Thr Glu Lys 
65                  70                  75                  80  


Arg Arg Arg Asp Lys Met Asn Asn Leu Ile Glu Glu Leu Ser Ala Met 
                85                  90                  95      


Ile Pro Gln Cys Asn Pro Met Ala Arg Lys Leu Asp Lys Leu Thr Val 
            100                 105                 110         


Leu Arg Met Ala Val Gln His Leu Arg Ser Leu Lys Gly Leu Thr Asn 
        115                 120                 125             


Ser Tyr Val Gly Ser Asn Tyr Arg Pro Ser Phe Leu Gln Asp Asn Glu 
    130                 135                 140                 


Leu Arg His Leu Ile Leu Lys Thr Ala Glu Gly Phe Leu Phe Val Val 
145                 150                 155                 160 


Gly Cys Glu Arg Gly Lys Ile Leu Phe Val Ser Lys Ser Val Ser Lys 
                165                 170                 175     


Ile Leu Asn Tyr Asp Gln Ala Ser Leu Thr Gly Gln Ser Leu Phe Asp 
            180                 185                 190         


Phe Leu His Pro Lys Asp Val Ala Lys Val Lys Glu Gln Leu Ser Ser 
        195                 200                 205             


Phe Asp Ile Ser Pro Arg Glu Lys Leu Ile Asp Ala Lys Thr Gly Leu 
    210                 215                 220                 


Gln Val His Ser Asn Leu His Ala Gly Arg Thr Arg Val Tyr Ser Gly 
225                 230                 235                 240 


Ser Arg Arg Ser Phe Phe Cys Arg Ile Lys Ser Cys Lys Ile Ser Val 
                245                 250                 255     


Lys Glu Glu His Gly Cys Leu Pro Asn Ser Lys Lys Lys Glu His Arg 
            260                 265                 270         


Lys Phe Tyr Thr Ile His Cys Thr Gly Tyr Leu Arg Ser Trp Pro Pro 
        275                 280                 285             


Asn Ile Val Gly Met Glu Glu Glu Arg Asn Ser Lys Lys Asp Asn Ser 
    290                 295                 300                 


Asn Phe Thr Cys Leu Val Ala Ile Gly Arg Leu Gln Pro Tyr Ile Val 
305                 310                 315                 320 


Pro Gln Asn Ser Gly Glu Ile Asn Val Lys Pro Thr Glu Phe Ile Thr 
                325                 330                 335     


Arg Phe Ala Val Asn Gly Lys Phe Val Tyr Val Asp Gln Arg Ala Thr 
            340                 345                 350         


Ala Ile Leu Gly Tyr Leu Pro Gln Glu Leu Leu Gly Thr Ser Cys Tyr 
        355                 360                 365             


Glu Tyr Phe His Gln Asp Asp His Asn Asn Leu Thr Asp Lys His Lys 
    370                 375                 380                 


Ala Val Leu Gln Ser Lys Glu Lys Ile Leu Thr Asp Ser Tyr Lys Phe 
385                 390                 395                 400 


Arg Ala Lys Asp Gly Ser Phe Val Thr Leu Lys Ser Gln Trp Phe Ser 
                405                 410                 415     


Phe Thr Asn Pro Trp Thr Lys Glu Leu Glu Tyr Ile Val Ser Val Asn 
            420                 425                 430         


Thr Leu Val Leu Gly His Ser Glu Pro Gly Glu Ala Ser Phe Leu Pro 
        435                 440                 445             


Cys Ser Ser Gln Ser Ser Glu Glu Ser Ser Arg Gln Ser Cys Met Ser 
    450                 455                 460                 


Val Pro Gly Met Ser Thr Gly Thr Val Leu Gly Ala Gly Ser Ile Gly 
465                 470                 475                 480 


Thr Asp Ile Ala Asn Glu Ile Leu Asp Leu Gln Arg Leu Gln Ser Ser 
                485                 490                 495     


Ser Tyr Leu Asp Asp Ser Ser Pro Thr Gly Leu Met Lys Asp Thr His 
            500                 505                 510         


Thr Val Asn Cys Arg Ser Met Ser Asn Lys Glu Leu Phe Pro Pro Ser 
        515                 520                 525             


Pro Ser Glu Met Gly Glu Leu Glu Ala Thr Arg Gln Asn Gln Ser Thr 
    530                 535                 540                 


Val Ala Val His Ser His Glu Pro Leu Leu Ser Asp Gly Ala Gln Leu 
545                 550                 555                 560 


Asp Phe Asp Ala Leu Cys Asp Asn Asp Asp Thr Ala Met Ala Ala Phe 
                565                 570                 575     


Met Asn Tyr Leu Glu Ala Glu Gly Gly Leu Gly Asp Pro Gly Asp Phe 
            580                 585                 590         


Ser Asp Ile Gln Trp Thr Leu 
        595                 


<210>  759
<211>  540
<212>  PRT
<213>  Homo sapiens

<400>  759

Met Ala Ala Glu Glu Glu Ala Ala Ala Gly Gly Glu Val Ala Gly Gly 
1               5                   10                  15      


Glu Ala Thr Ala Pro Gly Lys Val Leu Arg Glu Glu Asn Gln Cys Ile 
            20                  25                  30          


Ala Pro Val Val Ser Ser Arg Val Ser Pro Gly Thr Arg Pro Thr Ala 
        35                  40                  45              


Met Gly Ser Phe Ser Ser His Met Thr Glu Phe Pro Arg Lys Arg Lys 
    50                  55                  60                  


Gly Ser Asp Ser Asp Pro Ser Gln Glu Ala His Ser Gln Thr Glu Lys 
65                  70                  75                  80  


Arg Arg Arg Asp Lys Met Asn Asn Leu Ile Glu Glu Leu Ser Ala Met 
                85                  90                  95      


Ile Pro Gln Cys Asn Pro Met Ala Arg Lys Leu Asp Lys Leu Thr Val 
            100                 105                 110         


Leu Arg Met Ala Val Gln His Leu Arg Ser Leu Lys Gly Leu Thr Asn 
        115                 120                 125             


Ser Tyr Val Gly Ser Asn Tyr Arg Pro Ser Phe Leu Gln Asp Asn Glu 
    130                 135                 140                 


Leu Arg His Leu Ile Leu Lys Thr Ala Glu Gly Phe Leu Phe Val Val 
145                 150                 155                 160 


Gly Cys Glu Arg Gly Lys Ile Leu Phe Val Ser Lys Ser Val Ser Lys 
                165                 170                 175     


Ile Leu Asn Tyr Asp Gln Ala Ser Leu Thr Gly Gln Ser Leu Phe Asp 
            180                 185                 190         


Phe Leu His Pro Lys Asp Val Ala Lys Val Lys Glu Gln Leu Ser Ser 
        195                 200                 205             


Phe Asp Ile Ser Pro Arg Glu Lys Leu Ile Asp Ala Lys Thr Gly Leu 
    210                 215                 220                 


Gln Val His Ser Asn Leu His Ala Gly Arg Thr Arg Val Tyr Ser Gly 
225                 230                 235                 240 


Ser Arg Arg Ser Phe Phe Cys Arg Ile Lys Ser Cys Lys Ile Ser Val 
                245                 250                 255     


Lys Glu Glu His Gly Cys Leu Pro Asn Ser Lys Lys Lys Glu His Arg 
            260                 265                 270         


Lys Phe Tyr Thr Ile His Cys Thr Gly Tyr Leu Arg Ser Trp Pro Pro 
        275                 280                 285             


Asn Ile Val Gly Met Glu Glu Glu Arg Asn Ser Lys Lys Asp Asn Ser 
    290                 295                 300                 


Asn Phe Thr Cys Leu Val Ala Ile Gly Arg Leu Gln Pro Tyr Ile Val 
305                 310                 315                 320 


Pro Gln Asn Ser Gly Glu Ile Asn Val Lys Pro Thr Glu Phe Ile Thr 
                325                 330                 335     


Arg Phe Ala Val Asn Gly Lys Phe Val Tyr Val Asp Gln Arg Ala Thr 
            340                 345                 350         


Ala Ile Leu Gly Tyr Leu Pro Gln Glu Leu Leu Gly Thr Ser Cys Tyr 
        355                 360                 365             


Glu Tyr Phe His Gln Asp Asp His Asn Asn Leu Thr Asp Lys His Lys 
    370                 375                 380                 


Ala Val Leu Gln Ser Lys Glu Lys Ile Leu Thr Asp Ser Tyr Lys Phe 
385                 390                 395                 400 


Arg Ala Lys Asp Gly Ser Phe Val Thr Leu Lys Ser Gln Trp Phe Ser 
                405                 410                 415     


Phe Thr Asn Pro Trp Thr Lys Glu Leu Glu Tyr Ile Val Ser Val Asn 
            420                 425                 430         


Thr Leu Val Leu Gly His Ser Glu Pro Gly Glu Ala Ser Phe Leu Pro 
        435                 440                 445             


Cys Ser Ser Gln Ser Ser Glu Glu Ser Ser Arg Gln Ser Cys Met Ser 
    450                 455                 460                 


Val Pro Gly Met Ser Thr Gly Thr Val Leu Gly Ala Gly Ser Ile Gly 
465                 470                 475                 480 


Thr Asp Ile Ala Asn Glu Ile Leu Asp Leu Gln Arg Leu Gln Ser Ser 
                485                 490                 495     


Ser Tyr Leu Asp Asp Ser Ser Pro Thr Gly Leu Met Lys Asp Thr His 
            500                 505                 510         


Thr Val Asn Cys Arg Ser Val Met Val His Ser Trp Ile Ser Met Pro 
        515                 520                 525             


Tyr Val Thr Met Met Thr Gln Pro Trp Leu His Leu 
    530                 535                 540 


<210>  760
<211>  622
<212>  PRT
<213>  Homo sapiens

<400>  760

Met Ala Ala Glu Glu Glu Ala Ala Ala Gly Gly Lys Val Leu Arg Glu 
1               5                   10                  15      


Glu Asn Gln Cys Ile Ala Pro Val Val Ser Ser Arg Val Ser Pro Gly 
            20                  25                  30          


Thr Arg Pro Thr Ala Met Gly Ser Phe Ser Ser His Met Thr Glu Phe 
        35                  40                  45              


Pro Arg Lys Arg Lys Gly Ser Asp Ser Asp Pro Ser Gln Ser Gly Ile 
    50                  55                  60                  


Met Thr Glu Lys Val Val Glu Lys Leu Ser Gln Asn Pro Leu Thr Tyr 
65                  70                  75                  80  


Leu Leu Ser Thr Arg Ile Glu Ile Ser Ala Ser Ser Gly Ser Arg Glu 
                85                  90                  95      


Ala His Ser Gln Thr Glu Lys Arg Arg Arg Asp Lys Met Asn Asn Leu 
            100                 105                 110         


Ile Glu Glu Leu Ser Ala Met Ile Pro Gln Cys Asn Pro Met Ala Arg 
        115                 120                 125             


Lys Leu Asp Lys Leu Thr Val Leu Arg Met Ala Val Gln His Leu Arg 
    130                 135                 140                 


Ser Leu Lys Gly Leu Thr Asn Ser Tyr Val Gly Ser Asn Tyr Arg Pro 
145                 150                 155                 160 


Ser Phe Leu Gln Asp Asn Glu Leu Arg His Leu Ile Leu Lys Thr Ala 
                165                 170                 175     


Glu Gly Phe Leu Phe Val Val Gly Cys Glu Arg Gly Lys Ile Leu Phe 
            180                 185                 190         


Val Ser Lys Ser Val Ser Lys Ile Leu Asn Tyr Asp Gln Ala Ser Leu 
        195                 200                 205             


Thr Gly Gln Ser Leu Phe Asp Phe Leu His Pro Lys Asp Val Ala Lys 
    210                 215                 220                 


Val Lys Glu Gln Leu Ser Ser Phe Asp Ile Ser Pro Arg Glu Lys Leu 
225                 230                 235                 240 


Ile Asp Ala Lys Thr Gly Leu Gln Val His Ser Asn Leu His Ala Gly 
                245                 250                 255     


Arg Thr Arg Val Tyr Ser Gly Ser Arg Arg Ser Phe Phe Cys Arg Ile 
            260                 265                 270         


Lys Ser Cys Lys Ile Ser Val Lys Glu Glu His Gly Cys Leu Pro Asn 
        275                 280                 285             


Ser Lys Lys Lys Glu His Arg Lys Phe Tyr Thr Ile His Cys Thr Gly 
    290                 295                 300                 


Tyr Leu Arg Ser Trp Pro Pro Asn Ile Val Gly Met Glu Glu Glu Arg 
305                 310                 315                 320 


Asn Ser Lys Lys Asp Asn Ser Asn Phe Thr Cys Leu Val Ala Ile Gly 
                325                 330                 335     


Arg Leu Gln Pro Tyr Ile Val Pro Gln Asn Ser Gly Glu Ile Asn Val 
            340                 345                 350         


Lys Pro Thr Glu Phe Ile Thr Arg Phe Ala Val Asn Gly Lys Phe Val 
        355                 360                 365             


Tyr Val Asp Gln Arg Ala Thr Ala Ile Leu Gly Tyr Leu Pro Gln Glu 
    370                 375                 380                 


Leu Leu Gly Thr Ser Cys Tyr Glu Tyr Phe His Gln Asp Asp His Asn 
385                 390                 395                 400 


Asn Leu Thr Asp Lys His Lys Ala Val Leu Gln Ser Lys Glu Lys Ile 
                405                 410                 415     


Leu Thr Asp Ser Tyr Lys Phe Arg Ala Lys Asp Gly Ser Phe Val Thr 
            420                 425                 430         


Leu Lys Ser Gln Trp Phe Ser Phe Thr Asn Pro Trp Thr Lys Glu Leu 
        435                 440                 445             


Glu Tyr Ile Val Ser Val Asn Thr Leu Val Leu Gly His Ser Glu Pro 
    450                 455                 460                 


Gly Glu Ala Ser Phe Leu Pro Cys Ser Ser Gln Ser Ser Glu Glu Ser 
465                 470                 475                 480 


Ser Arg Gln Ser Cys Met Ser Val Pro Gly Met Ser Thr Gly Thr Val 
                485                 490                 495     


Leu Gly Ala Gly Ser Ile Gly Thr Asp Ile Ala Asn Glu Ile Leu Asp 
            500                 505                 510         


Leu Gln Arg Leu Gln Ser Ser Ser Tyr Leu Asp Asp Ser Ser Pro Thr 
        515                 520                 525             


Gly Leu Met Lys Asp Thr His Thr Val Asn Cys Arg Ser Met Ser Asn 
    530                 535                 540                 


Lys Glu Leu Phe Pro Pro Ser Pro Ser Glu Met Gly Glu Leu Glu Ala 
545                 550                 555                 560 


Thr Arg Gln Asn Gln Ser Thr Val Ala Val His Ser His Glu Pro Leu 
                565                 570                 575     


Leu Ser Asp Gly Ala Gln Leu Asp Phe Asp Ala Leu Cys Asp Asn Asp 
            580                 585                 590         


Asp Thr Ala Met Ala Ala Phe Met Asn Tyr Leu Glu Ala Glu Gly Gly 
        595                 600                 605             


Leu Gly Asp Pro Gly Asp Phe Ser Asp Ile Gln Trp Thr Leu 
    610                 615                 620         


<210>  761
<211>  588
<212>  PRT
<213>  Homo sapiens

<400>  761

Met Ala Ala Glu Glu Glu Ala Ala Ala Gly Gly Lys Val Leu Arg Glu 
1               5                   10                  15      


Glu Asn Gln Cys Ile Ala Pro Val Val Ser Ser Arg Val Ser Pro Gly 
            20                  25                  30          


Thr Arg Pro Thr Ala Met Gly Ser Phe Ser Ser His Met Thr Glu Phe 
        35                  40                  45              


Pro Arg Lys Arg Lys Gly Ser Asp Ser Asp Pro Ser Gln Glu Ala His 
    50                  55                  60                  


Ser Gln Thr Glu Lys Arg Arg Arg Asp Lys Met Asn Asn Leu Ile Glu 
65                  70                  75                  80  


Glu Leu Ser Ala Met Ile Pro Gln Cys Asn Pro Met Ala Arg Lys Leu 
                85                  90                  95      


Asp Lys Leu Thr Val Leu Arg Met Ala Val Gln His Leu Arg Ser Leu 
            100                 105                 110         


Lys Gly Leu Thr Asn Ser Tyr Val Gly Ser Asn Tyr Arg Pro Ser Phe 
        115                 120                 125             


Leu Gln Asp Asn Glu Leu Arg His Leu Ile Leu Lys Thr Ala Glu Gly 
    130                 135                 140                 


Phe Leu Phe Val Val Gly Cys Glu Arg Gly Lys Ile Leu Phe Val Ser 
145                 150                 155                 160 


Lys Ser Val Ser Lys Ile Leu Asn Tyr Asp Gln Ala Ser Leu Thr Gly 
                165                 170                 175     


Gln Ser Leu Phe Asp Phe Leu His Pro Lys Asp Val Ala Lys Val Lys 
            180                 185                 190         


Glu Gln Leu Ser Ser Phe Asp Ile Ser Pro Arg Glu Lys Leu Ile Asp 
        195                 200                 205             


Ala Lys Thr Gly Leu Gln Val His Ser Asn Leu His Ala Gly Arg Thr 
    210                 215                 220                 


Arg Val Tyr Ser Gly Ser Arg Arg Ser Phe Phe Cys Arg Ile Lys Ser 
225                 230                 235                 240 


Cys Lys Ile Ser Val Lys Glu Glu His Gly Cys Leu Pro Asn Ser Lys 
                245                 250                 255     


Lys Lys Glu His Arg Lys Phe Tyr Thr Ile His Cys Thr Gly Tyr Leu 
            260                 265                 270         


Arg Ser Trp Pro Pro Asn Ile Val Gly Met Glu Glu Glu Arg Asn Ser 
        275                 280                 285             


Lys Lys Asp Asn Ser Asn Phe Thr Cys Leu Val Ala Ile Gly Arg Leu 
    290                 295                 300                 


Gln Pro Tyr Ile Val Pro Gln Asn Ser Gly Glu Ile Asn Val Lys Pro 
305                 310                 315                 320 


Thr Glu Phe Ile Thr Arg Phe Ala Val Asn Gly Lys Phe Val Tyr Val 
                325                 330                 335     


Asp Gln Arg Ala Thr Ala Ile Leu Gly Tyr Leu Pro Gln Glu Leu Leu 
            340                 345                 350         


Gly Thr Ser Cys Tyr Glu Tyr Phe His Gln Asp Asp His Asn Asn Leu 
        355                 360                 365             


Thr Asp Lys His Lys Ala Val Leu Gln Ser Lys Glu Lys Ile Leu Thr 
    370                 375                 380                 


Asp Ser Tyr Lys Phe Arg Ala Lys Asp Gly Ser Phe Val Thr Leu Lys 
385                 390                 395                 400 


Ser Gln Trp Phe Ser Phe Thr Asn Pro Trp Thr Lys Glu Leu Glu Tyr 
                405                 410                 415     


Ile Val Ser Val Asn Thr Leu Val Leu Gly His Ser Glu Pro Gly Glu 
            420                 425                 430         


Ala Ser Phe Leu Pro Cys Ser Ser Gln Ser Ser Glu Glu Ser Ser Arg 
        435                 440                 445             


Gln Ser Cys Met Ser Val Pro Gly Met Ser Thr Gly Thr Val Leu Gly 
    450                 455                 460                 


Ala Gly Ser Ile Gly Thr Asp Ile Ala Asn Glu Ile Leu Asp Leu Gln 
465                 470                 475                 480 


Arg Leu Gln Ser Ser Ser Tyr Leu Asp Asp Ser Ser Pro Thr Gly Leu 
                485                 490                 495     


Met Lys Asp Thr His Thr Val Asn Cys Arg Ser Met Ser Asn Lys Glu 
            500                 505                 510         


Leu Phe Pro Pro Ser Pro Ser Glu Met Gly Glu Leu Glu Ala Thr Arg 
        515                 520                 525             


Gln Asn Gln Ser Thr Val Ala Val His Ser His Glu Pro Leu Leu Ser 
    530                 535                 540                 


Asp Gly Ala Gln Leu Asp Phe Asp Ala Leu Cys Asp Asn Asp Asp Thr 
545                 550                 555                 560 


Ala Met Ala Ala Phe Met Asn Tyr Leu Glu Ala Glu Gly Gly Leu Gly 
                565                 570                 575     


Asp Pro Gly Asp Phe Ser Asp Ile Gln Trp Thr Leu 
            580                 585             


<210>  762
<211>  636
<212>  PRT
<213>  Homo sapiens

<400>  762

Met Ala Ala Glu Glu Glu Ala Ala Ala Gly Gly Lys Val Leu Arg Glu 
1               5                   10                  15      


Glu Asn Gln Cys Ile Ala Pro Val Val Ser Ser Arg Val Ser Pro Gly 
            20                  25                  30          


Thr Arg Pro Thr Ala Met Gly Ser Phe Ser Ser His Met Thr Glu Phe 
        35                  40                  45              


Pro Arg Lys Arg Lys Gly Ser Asp Ser Asp Pro Ser Gln Ser Gly Ile 
    50                  55                  60                  


Met Thr Glu Lys Val Val Glu Lys Leu Ser Gln Asn Pro Leu Thr Tyr 
65                  70                  75                  80  


Leu Leu Ser Thr Arg Ile Glu Ile Ser Ala Ser Ser Gly Ser Arg Val 
                85                  90                  95      


Glu Asp Gly Glu His Gln Val Lys Met Lys Ala Phe Arg Glu Ala His 
            100                 105                 110         


Ser Gln Thr Glu Lys Arg Arg Arg Asp Lys Met Asn Asn Leu Ile Glu 
        115                 120                 125             


Glu Leu Ser Ala Met Ile Pro Gln Cys Asn Pro Met Ala Arg Lys Leu 
    130                 135                 140                 


Asp Lys Leu Thr Val Leu Arg Met Ala Val Gln His Leu Arg Ser Leu 
145                 150                 155                 160 


Lys Gly Leu Thr Asn Ser Tyr Val Gly Ser Asn Tyr Arg Pro Ser Phe 
                165                 170                 175     


Leu Gln Asp Asn Glu Leu Arg His Leu Ile Leu Lys Thr Ala Glu Gly 
            180                 185                 190         


Phe Leu Phe Val Val Gly Cys Glu Arg Gly Lys Ile Leu Phe Val Ser 
        195                 200                 205             


Lys Ser Val Ser Lys Ile Leu Asn Tyr Asp Gln Ala Ser Leu Thr Gly 
    210                 215                 220                 


Gln Ser Leu Phe Asp Phe Leu His Pro Lys Asp Val Ala Lys Val Lys 
225                 230                 235                 240 


Glu Gln Leu Ser Ser Phe Asp Ile Ser Pro Arg Glu Lys Leu Ile Asp 
                245                 250                 255     


Ala Lys Thr Gly Leu Gln Val His Ser Asn Leu His Ala Gly Arg Thr 
            260                 265                 270         


Arg Val Tyr Ser Gly Ser Arg Arg Ser Phe Phe Cys Arg Ile Lys Ser 
        275                 280                 285             


Cys Lys Ile Ser Val Lys Glu Glu His Gly Cys Leu Pro Asn Ser Lys 
    290                 295                 300                 


Lys Lys Glu His Arg Lys Phe Tyr Thr Ile His Cys Thr Gly Tyr Leu 
305                 310                 315                 320 


Arg Ser Trp Pro Pro Asn Ile Val Gly Met Glu Glu Glu Arg Asn Ser 
                325                 330                 335     


Lys Lys Asp Asn Ser Asn Phe Thr Cys Leu Val Ala Ile Gly Arg Leu 
            340                 345                 350         


Gln Pro Tyr Ile Val Pro Gln Asn Ser Gly Glu Ile Asn Val Lys Pro 
        355                 360                 365             


Thr Glu Phe Ile Thr Arg Phe Ala Val Asn Gly Lys Phe Val Tyr Val 
    370                 375                 380                 


Asp Gln Arg Ala Thr Ala Ile Leu Gly Tyr Leu Pro Gln Glu Leu Leu 
385                 390                 395                 400 


Gly Thr Ser Cys Tyr Glu Tyr Phe His Gln Asp Asp His Asn Asn Leu 
                405                 410                 415     


Thr Asp Lys His Lys Ala Val Leu Gln Ser Lys Glu Lys Ile Leu Thr 
            420                 425                 430         


Asp Ser Tyr Lys Phe Arg Ala Lys Asp Gly Ser Phe Val Thr Leu Lys 
        435                 440                 445             


Ser Gln Trp Phe Ser Phe Thr Asn Pro Trp Thr Lys Glu Leu Glu Tyr 
    450                 455                 460                 


Ile Val Ser Val Asn Thr Leu Val Leu Gly His Ser Glu Pro Gly Glu 
465                 470                 475                 480 


Ala Ser Phe Leu Pro Cys Ser Ser Gln Ser Ser Glu Glu Ser Ser Arg 
                485                 490                 495     


Gln Ser Cys Met Ser Val Pro Gly Met Ser Thr Gly Thr Val Leu Gly 
            500                 505                 510         


Ala Gly Ser Ile Gly Thr Asp Ile Ala Asn Glu Ile Leu Asp Leu Gln 
        515                 520                 525             


Arg Leu Gln Ser Ser Ser Tyr Leu Asp Asp Ser Ser Pro Thr Gly Leu 
    530                 535                 540                 


Met Lys Asp Thr His Thr Val Asn Cys Arg Ser Met Ser Asn Lys Glu 
545                 550                 555                 560 


Leu Phe Pro Pro Ser Pro Ser Glu Met Gly Glu Leu Glu Ala Thr Arg 
                565                 570                 575     


Gln Asn Gln Ser Thr Val Ala Val His Ser His Glu Pro Leu Leu Ser 
            580                 585                 590         


Asp Gly Ala Gln Leu Asp Phe Asp Ala Leu Cys Asp Asn Asp Asp Thr 
        595                 600                 605             


Ala Met Ala Ala Phe Met Asn Tyr Leu Glu Ala Glu Gly Gly Leu Gly 
    610                 615                 620                 


Asp Pro Gly Asp Phe Ser Asp Ile Gln Trp Thr Leu 
625                 630                 635     


<210>  763
<211>  588
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  763

Xaa Pro Val Val Ser Ser Arg Val Ser Pro Gly Thr Arg Pro Thr Ala 
1               5                   10                  15      


Met Gly Ser Phe Ser Ser His Met Thr Glu Phe Pro Arg Lys Arg Lys 
            20                  25                  30          


Gly Ser Asp Ser Asp Pro Ser His Gln Asn Pro Leu Thr Tyr Leu Leu 
        35                  40                  45              


Ser Thr Arg Ile Glu Ile Ser Ala Ser Ser Gly Ser Arg Glu Ala His 
    50                  55                  60                  


Ser Gln Thr Glu Lys Arg Arg Arg Asp Lys Met Asn Asn Leu Ile Glu 
65                  70                  75                  80  


Glu Leu Ser Ala Met Ile Pro Gln Cys Asn Pro Met Ala Arg Lys Leu 
                85                  90                  95      


Asp Lys Leu Thr Val Leu Arg Met Ala Val Gln His Leu Arg Ser Leu 
            100                 105                 110         


Lys Gly Leu Thr Asn Ser Tyr Val Gly Ser Asn Tyr Arg Pro Ser Phe 
        115                 120                 125             


Leu Gln Asp Asn Glu Leu Arg His Leu Ile Leu Lys Thr Ala Glu Gly 
    130                 135                 140                 


Phe Leu Phe Val Val Gly Cys Glu Arg Gly Lys Ile Leu Phe Val Ser 
145                 150                 155                 160 


Lys Ser Val Ser Lys Ile Leu Asn Tyr Asp Gln Ala Ser Leu Thr Gly 
                165                 170                 175     


Gln Ser Leu Phe Asp Phe Leu His Pro Lys Asp Val Ala Lys Val Lys 
            180                 185                 190         


Glu Gln Leu Ser Ser Phe Asp Ile Ser Pro Arg Glu Lys Leu Ile Asp 
        195                 200                 205             


Ala Lys Thr Gly Leu Gln Val His Ser Asn Leu His Ala Gly Arg Thr 
    210                 215                 220                 


Arg Val Tyr Ser Gly Ser Arg Arg Ser Phe Phe Cys Arg Ile Lys Ser 
225                 230                 235                 240 


Cys Lys Ile Ser Val Lys Glu Glu His Gly Cys Leu Pro Asn Ser Lys 
                245                 250                 255     


Lys Lys Glu His Arg Lys Phe Tyr Thr Ile His Cys Thr Gly Tyr Leu 
            260                 265                 270         


Arg Ser Trp Pro Pro Asn Ile Val Gly Met Glu Glu Glu Arg Asn Ser 
        275                 280                 285             


Lys Lys Asp Asn Ser Asn Phe Thr Cys Leu Val Ala Ile Gly Arg Leu 
    290                 295                 300                 


Gln Pro Tyr Ile Val Pro Gln Asn Ser Gly Glu Ile Asn Val Lys Pro 
305                 310                 315                 320 


Thr Glu Phe Ile Thr Arg Phe Ala Val Asn Gly Lys Phe Val Tyr Val 
                325                 330                 335     


Asp Gln Arg Ala Thr Ala Ile Leu Gly Tyr Leu Pro Gln Glu Leu Leu 
            340                 345                 350         


Gly Thr Ser Cys Tyr Glu Tyr Phe His Gln Asp Asp His Asn Asn Leu 
        355                 360                 365             


Thr Asp Lys His Lys Ala Val Leu Gln Ser Lys Glu Lys Ile Leu Thr 
    370                 375                 380                 


Asp Ser Tyr Lys Phe Arg Ala Lys Asp Gly Ser Phe Val Thr Leu Lys 
385                 390                 395                 400 


Ser Gln Trp Phe Ser Phe Thr Asn Pro Trp Thr Lys Glu Leu Glu Tyr 
                405                 410                 415     


Ile Val Ser Val Asn Thr Leu Val Leu Gly His Ser Glu Pro Gly Glu 
            420                 425                 430         


Ala Ser Phe Leu Pro Cys Ser Ser Gln Ser Ser Glu Glu Ser Ser Arg 
        435                 440                 445             


Gln Ser Cys Met Ser Val Pro Gly Met Ser Thr Gly Thr Val Leu Gly 
    450                 455                 460                 


Ala Gly Ser Ile Gly Thr Asp Ile Ala Asn Glu Ile Leu Asp Leu Gln 
465                 470                 475                 480 


Arg Leu Gln Ser Ser Ser Tyr Leu Asp Asp Ser Ser Pro Thr Gly Leu 
                485                 490                 495     


Met Lys Asp Thr His Thr Val Asn Cys Arg Ser Met Ser Asn Lys Glu 
            500                 505                 510         


Leu Phe Pro Pro Ser Pro Ser Glu Met Gly Glu Leu Glu Ala Thr Arg 
        515                 520                 525             


Gln Asn Gln Ser Thr Val Ala Val His Ser His Glu Pro Leu Leu Ser 
    530                 535                 540                 


Asp Gly Ala Gln Leu Asp Phe Asp Ala Leu Cys Asp Asn Asp Asp Thr 
545                 550                 555                 560 


Ala Met Ala Ala Phe Met Asn Tyr Leu Glu Ala Glu Gly Gly Leu Gly 
                565                 570                 575     


Asp Pro Gly Asp Phe Ser Asp Ile Gln Trp Thr Leu 
            580                 585             


<210>  764
<211>  551
<212>  PRT
<213>  Homo sapiens

<400>  764

Met Gly Ser Phe Ser Ser His Met Thr Glu Phe Pro Arg Lys Arg Lys 
1               5                   10                  15      


Gly Ser Asp Ser Asp Pro Ser Gln Glu Ala His Ser Gln Thr Glu Lys 
            20                  25                  30          


Arg Arg Arg Asp Lys Met Asn Asn Leu Ile Glu Glu Leu Ser Ala Met 
        35                  40                  45              


Ile Pro Gln Cys Asn Pro Met Ala Arg Lys Leu Asp Lys Leu Thr Val 
    50                  55                  60                  


Leu Arg Met Ala Val Gln His Leu Arg Ser Leu Lys Gly Leu Thr Asn 
65                  70                  75                  80  


Ser Tyr Val Gly Ser Asn Tyr Arg Pro Ser Phe Leu Gln Asp Asn Glu 
                85                  90                  95      


Leu Arg His Leu Ile Leu Lys Thr Ala Glu Gly Phe Leu Phe Val Val 
            100                 105                 110         


Gly Cys Glu Arg Gly Lys Ile Leu Phe Val Ser Lys Ser Val Ser Lys 
        115                 120                 125             


Ile Leu Asn Tyr Asp Gln Ala Ser Leu Thr Gly Gln Ser Leu Phe Asp 
    130                 135                 140                 


Phe Leu His Pro Lys Asp Val Ala Lys Val Lys Glu Gln Leu Ser Ser 
145                 150                 155                 160 


Phe Asp Ile Ser Pro Arg Glu Lys Leu Ile Asp Ala Lys Thr Gly Leu 
                165                 170                 175     


Gln Val His Ser Asn Leu His Ala Gly Arg Thr Arg Val Tyr Ser Gly 
            180                 185                 190         


Ser Arg Arg Ser Phe Phe Cys Arg Ile Lys Ser Cys Lys Ile Ser Val 
        195                 200                 205             


Lys Glu Glu His Gly Cys Leu Pro Asn Ser Lys Lys Lys Glu His Arg 
    210                 215                 220                 


Lys Phe Tyr Thr Ile His Cys Thr Gly Tyr Leu Arg Ser Trp Pro Pro 
225                 230                 235                 240 


Asn Ile Val Gly Met Glu Glu Glu Arg Asn Ser Lys Lys Asp Asn Ser 
                245                 250                 255     


Asn Phe Thr Cys Leu Val Ala Ile Gly Arg Leu Gln Pro Tyr Ile Val 
            260                 265                 270         


Pro Gln Asn Ser Gly Glu Ile Asn Val Lys Pro Thr Glu Phe Ile Thr 
        275                 280                 285             


Arg Phe Ala Val Asn Gly Lys Phe Val Tyr Val Asp Gln Arg Ala Thr 
    290                 295                 300                 


Ala Ile Leu Gly Tyr Leu Pro Gln Glu Leu Leu Gly Thr Ser Cys Tyr 
305                 310                 315                 320 


Glu Tyr Phe His Gln Asp Asp His Asn Asn Leu Thr Asp Lys His Lys 
                325                 330                 335     


Ala Val Leu Gln Ser Lys Glu Lys Ile Leu Thr Asp Ser Tyr Lys Phe 
            340                 345                 350         


Arg Ala Lys Asp Gly Ser Phe Val Thr Leu Lys Ser Gln Trp Phe Ser 
        355                 360                 365             


Phe Thr Asn Pro Trp Thr Lys Glu Leu Glu Tyr Ile Val Ser Val Asn 
    370                 375                 380                 


Thr Leu Val Leu Gly His Ser Glu Pro Gly Glu Ala Ser Phe Leu Pro 
385                 390                 395                 400 


Cys Ser Ser Gln Ser Ser Glu Glu Ser Ser Arg Gln Ser Cys Met Ser 
                405                 410                 415     


Val Pro Gly Met Ser Thr Gly Thr Val Leu Gly Ala Gly Ser Ile Gly 
            420                 425                 430         


Thr Asp Ile Ala Asn Glu Ile Leu Asp Leu Gln Arg Leu Gln Ser Ser 
        435                 440                 445             


Ser Tyr Leu Asp Asp Ser Ser Pro Thr Gly Leu Met Lys Asp Thr His 
    450                 455                 460                 


Thr Val Asn Cys Arg Ser Met Ser Asn Lys Glu Leu Phe Pro Pro Ser 
465                 470                 475                 480 


Pro Ser Glu Met Gly Glu Leu Glu Ala Thr Arg Gln Asn Gln Ser Thr 
                485                 490                 495     


Val Ala Val His Ser His Glu Pro Leu Leu Ser Asp Gly Ala Gln Leu 
            500                 505                 510         


Asp Phe Asp Ala Leu Cys Asp Asn Asp Asp Thr Ala Met Ala Ala Phe 
        515                 520                 525             


Met Asn Tyr Leu Glu Ala Glu Gly Gly Leu Gly Asp Pro Gly Asp Phe 
    530                 535                 540                 


Ser Asp Ile Gln Trp Thr Leu 
545                 550     


<210>  765
<211>  125
<212>  PRT
<213>  Homo sapiens

<400>  765

Met Pro His Ser Ser Asp Ser Ser Asp Ser Ser Phe Ser Arg Ser Pro 
1               5                   10                  15      


Pro Pro Gly Lys Gln Asp Ser Ser Asp Asp Val Arg Arg Val Gln Arg 
            20                  25                  30          


Arg Glu Lys Asn Arg Ile Ala Ala Gln Lys Ser Arg Gln Arg Gln Thr 
        35                  40                  45              


Gln Lys Ala Asp Thr Leu His Leu Glu Ser Glu Asp Leu Glu Lys Gln 
    50                  55                  60                  


Asn Ala Ala Leu Arg Lys Glu Ile Lys Gln Leu Thr Glu Glu Leu Lys 
65                  70                  75                  80  


Tyr Phe Thr Ser Val Leu Asn Ser His Glu Pro Leu Cys Ser Val Leu 
                85                  90                  95      


Ala Ala Ser Thr Pro Ser Pro Pro Glu Val Val Tyr Ser Ala His Ala 
            100                 105                 110         


Phe His Gln Pro His Val Ser Ser Pro Arg Phe Gln Pro 
        115                 120                 125 


<210>  766
<211>  73
<212>  PRT
<213>  Homo sapiens

<400>  766

Met Pro His Ser Ser Asp Ser Ser Asp Ser Ser Phe Ser Arg Ser Pro 
1               5                   10                  15      


Pro Pro Gly Lys Gln Asp Ser Ser Asp Asp Val Arg Arg Val Gln Arg 
            20                  25                  30          


Arg Glu Lys Asn Arg Ile Ala Ala Gln Lys Ser Arg Gln Arg Gln Thr 
        35                  40                  45              


Gln Lys Ser Ile Lys Lys Asp Ala Gln Val Pro Trp His Arg Ala Arg 
    50                  55                  60                  


Arg Ala Gly Asn Gly Tyr Phe Ser Lys 
65                  70              


<210>  767
<211>  202
<212>  PRT
<213>  Homo sapiens

<400>  767

Met Ala Thr Leu Ile Tyr Val Asp Lys Glu Asn Gly Glu Pro Gly Thr 
1               5                   10                  15      


Arg Val Val Ala Lys Asp Gly Leu Lys Leu Gly Ser Gly Pro Ser Ile 
            20                  25                  30          


Lys Ala Leu Asp Gly Arg Ser Gln Val Ser Thr Pro Arg Phe Gly Lys 
        35                  40                  45              


Thr Phe Asp Ala Pro Pro Ala Leu Pro Lys Ala Thr Arg Lys Ala Leu 
    50                  55                  60                  


Gly Thr Val Asn Arg Ala Thr Glu Lys Ser Val Lys Thr Lys Gly Pro 
65                  70                  75                  80  


Leu Lys Gln Lys Gln Pro Ser Phe Ser Ala Lys Lys Met Thr Glu Lys 
                85                  90                  95      


Thr Val Lys Ala Lys Ser Ser Val Pro Ala Ser Asp Asp Ala Tyr Pro 
            100                 105                 110         


Glu Ile Glu Lys Phe Phe Pro Phe Asn Pro Leu Asp Phe Glu Ser Phe 
        115                 120                 125             


Asp Leu Pro Glu Glu His Gln Ile Ala His Leu Pro Leu Ser Gly Val 
    130                 135                 140                 


Pro Leu Met Ile Leu Asp Glu Glu Arg Glu Leu Glu Lys Leu Phe Gln 
145                 150                 155                 160 


Leu Gly Pro Pro Ser Pro Val Lys Met Pro Ser Pro Pro Trp Glu Ser 
                165                 170                 175     


Asn Leu Leu Gln Ser Pro Ser Ser Ile Leu Ser Thr Leu Asp Val Glu 
            180                 185                 190         


Leu Pro Pro Val Cys Cys Asp Ile Asp Ile 
        195                 200         


<210>  768
<211>  121
<212>  PRT
<213>  Homo sapiens

<400>  768

Met Pro Leu Pro Lys Val Gly Gly Gly Phe Gly Gly Glu Arg Ser Ser 
1               5                   10                  15      


Leu Tyr Thr Gln Tyr Leu Ser Cys Thr Gly Ile Leu Leu Leu Glu Tyr 
            20                  25                  30          


Ser Tyr Gly Lys Thr Phe Ser Ser Ala Ile Lys Ala Leu Asp Gly Arg 
        35                  40                  45              


Ser Gln Val Ser Thr Pro Arg Phe Gly Lys Thr Phe Asp Ala Pro Pro 
    50                  55                  60                  


Ala Leu Pro Lys Ala Thr Arg Lys Ala Leu Gly Thr Val Asn Arg Ala 
65                  70                  75                  80  


Thr Glu Lys Ser Val Lys Thr Lys Gly Pro Leu Lys Gln Lys Gln Pro 
                85                  90                  95      


Ser Phe Ser Ala Lys Lys Met Thr Glu Lys Thr Val Lys Ala Lys Ser 
            100                 105                 110         


Ser Val Pro Ala Ser Asp Asp Ala Tyr 
        115                 120     


<210>  769
<211>  202
<212>  PRT
<213>  Homo sapiens

<400>  769

Met Ala Thr Leu Ile Tyr Val Asp Lys Glu Asn Gly Glu Pro Gly Thr 
1               5                   10                  15      


Arg Val Val Ala Lys Asp Gly Leu Lys Leu Gly Ser Gly Pro Ser Ile 
            20                  25                  30          


Lys Ala Leu Asp Gly Arg Ser Gln Val Ser Thr Pro Arg Phe Gly Lys 
        35                  40                  45              


Thr Phe Asp Ala Pro Pro Ala Leu Pro Lys Ala Thr Arg Lys Ala Leu 
    50                  55                  60                  


Gly Thr Val Asn Arg Ala Thr Glu Lys Ser Val Lys Thr Lys Gly Pro 
65                  70                  75                  80  


Leu Lys Gln Lys Gln Pro Ser Phe Ser Ala Lys Lys Met Thr Glu Lys 
                85                  90                  95      


Thr Val Lys Ala Lys Ser Ser Val Pro Ala Ser Asp Asp Ala Tyr Pro 
            100                 105                 110         


Glu Ile Glu Lys Phe Phe Pro Phe Asn Pro Leu Asp Phe Glu Ser Phe 
        115                 120                 125             


Asp Leu Pro Glu Glu His Gln Ile Ala His Leu Pro Leu Ser Gly Val 
    130                 135                 140                 


Pro Leu Met Ile Leu Asp Glu Glu Arg Glu Leu Glu Lys Leu Phe Gln 
145                 150                 155                 160 


Leu Gly Pro Pro Ser Pro Val Lys Met Pro Ser Pro Pro Trp Glu Ser 
                165                 170                 175     


Asn Leu Leu Gln Ser Pro Ser Ser Ile Leu Ser Thr Leu Asp Val Glu 
            180                 185                 190         


Leu Pro Pro Val Cys Cys Asp Ile Asp Ile 
        195                 200         


<210>  770
<211>  202
<212>  PRT
<213>  Homo sapiens

<400>  770

Met Ala Thr Leu Ile Tyr Val Asp Lys Glu Asn Gly Glu Pro Gly Thr 
1               5                   10                  15      


Arg Val Val Ala Lys Asp Gly Leu Lys Leu Gly Ser Gly Pro Ser Ile 
            20                  25                  30          


Lys Ala Leu Asp Gly Arg Ser Gln Val Ser Thr Pro Arg Phe Gly Lys 
        35                  40                  45              


Thr Phe Asp Ala Pro Pro Ala Leu Pro Lys Ala Thr Arg Lys Ala Leu 
    50                  55                  60                  


Gly Thr Val Asn Arg Ala Thr Glu Lys Ser Val Lys Thr Lys Gly Pro 
65                  70                  75                  80  


Leu Lys Gln Lys Gln Pro Ser Phe Ser Ala Lys Lys Met Thr Glu Lys 
                85                  90                  95      


Thr Val Lys Ala Lys Ser Ser Val Pro Ala Ser Asp Asp Ala Tyr Pro 
            100                 105                 110         


Glu Ile Glu Lys Phe Phe Pro Phe Asn Pro Leu Asp Phe Glu Ser Phe 
        115                 120                 125             


Asp Leu Pro Glu Glu His Gln Ile Ala His Leu Pro Leu Ser Gly Val 
    130                 135                 140                 


Pro Leu Met Ile Leu Asp Glu Glu Arg Glu Leu Glu Lys Leu Phe Gln 
145                 150                 155                 160 


Leu Gly Pro Pro Ser Pro Val Lys Met Pro Ser Pro Pro Trp Glu Ser 
                165                 170                 175     


Asn Leu Leu Gln Ser Pro Ser Ser Ile Leu Ser Thr Leu Asp Val Glu 
            180                 185                 190         


Leu Pro Pro Val Cys Cys Asp Ile Asp Ile 
        195                 200         


<210>  771
<211>  2406
<212>  PRT
<213>  Homo sapiens

<400>  771

Met Asp Pro Glu Gln Ser Val Lys Gly Thr Lys Lys Ala Glu Gly Ser 
1               5                   10                  15      


Pro Arg Lys Arg Leu Thr Lys Gly Glu Ala Ile Gln Thr Ser Val Ser 
            20                  25                  30          


Ser Ser Val Pro Tyr Pro Gly Ser Gly Thr Ala Ala Thr Gln Glu Ser 
        35                  40                  45              


Pro Ala Gln Glu Leu Leu Ala Pro Gln Pro Phe Pro Gly Pro Ser Ser 
    50                  55                  60                  


Val Leu Arg Glu Gly Ser Gln Glu Lys Thr Gly Gln Gln Gln Lys Pro 
65                  70                  75                  80  


Pro Lys Arg Pro Pro Ile Glu Ala Ser Val His Ile Ser Gln Leu Pro 
                85                  90                  95      


Gln His Pro Leu Thr Pro Ala Phe Met Ser Pro Gly Lys Pro Glu His 
            100                 105                 110         


Leu Leu Glu Gly Ser Thr Trp Gln Leu Val Asp Pro Met Arg Pro Gly 
        115                 120                 125             


Pro Ser Gly Ser Phe Val Ala Pro Gly Leu His Pro Gln Ser Gln Leu 
    130                 135                 140                 


Leu Pro Ser His Ala Ser Ile Ile Pro Pro Glu Asp Leu Pro Gly Val 
145                 150                 155                 160 


Pro Lys Val Phe Val Pro Arg Pro Ser Gln Val Ser Leu Lys Pro Thr 
                165                 170                 175     


Glu Glu Ala His Lys Lys Glu Arg Lys Pro Gln Lys Pro Gly Lys Tyr 
            180                 185                 190         


Ile Cys Gln Tyr Cys Ser Arg Pro Cys Ala Lys Pro Ser Val Leu Gln 
        195                 200                 205             


Lys His Ile Arg Ser His Thr Gly Glu Arg Pro Tyr Pro Cys Gly Pro 
    210                 215                 220                 


Cys Gly Phe Ser Phe Lys Thr Lys Ser Asn Leu Tyr Lys His Arg Lys 
225                 230                 235                 240 


Ser His Ala His Arg Ile Lys Ala Gly Leu Ala Ser Gly Met Gly Gly 
                245                 250                 255     


Glu Met Tyr Pro His Gly Leu Glu Met Glu Arg Ile Pro Gly Glu Glu 
            260                 265                 270         


Phe Glu Glu Pro Thr Glu Gly Glu Ser Thr Asp Ser Glu Glu Glu Thr 
        275                 280                 285             


Ser Ala Thr Ser Gly His Pro Ala Glu Leu Ser Pro Arg Pro Lys Gln 
    290                 295                 300                 


Pro Leu Leu Ser Ser Gly Leu Tyr Ser Ser Gly Ser His Ser Ser Ser 
305                 310                 315                 320 


His Glu Arg Cys Ser Leu Ser Gln Ser Ser Thr Ala Gln Ser Leu Glu 
                325                 330                 335     


Asp Pro Pro Pro Phe Val Glu Pro Ser Ser Glu His Pro Leu Ser His 
            340                 345                 350         


Lys Pro Glu Asp Thr His Thr Ile Lys Gln Lys Leu Ala Leu Arg Leu 
        355                 360                 365             


Ser Glu Arg Lys Lys Val Ile Asp Glu Gln Ala Phe Leu Ser Pro Gly 
    370                 375                 380                 


Ser Lys Gly Ser Thr Glu Ser Gly Tyr Phe Ser Arg Ser Glu Ser Ala 
385                 390                 395                 400 


Glu Gln Gln Val Ser Pro Pro Asn Thr Asn Ala Lys Ser Tyr Ala Glu 
                405                 410                 415     


Ile Ile Phe Gly Lys Cys Gly Arg Ile Gly Gln Arg Thr Ala Met Leu 
            420                 425                 430         


Thr Ala Thr Ser Thr Gln Pro Leu Leu Pro Leu Ser Thr Glu Asp Lys 
        435                 440                 445             


Pro Ser Leu Val Pro Leu Ser Val Pro Arg Thr Gln Val Ile Glu His 
    450                 455                 460                 


Ile Thr Lys Leu Ile Thr Ile Asn Glu Ala Val Val Asp Thr Ser Glu 
465                 470                 475                 480 


Ile Asp Ser Val Lys Pro Arg Arg Ser Ser Leu Ser Arg Arg Ser Ser 
                485                 490                 495     


Met Glu Ser Pro Lys Ser Ser Leu Tyr Arg Glu Pro Leu Ser Ser His 
            500                 505                 510         


Ser Glu Lys Thr Lys Pro Glu Gln Ser Leu Leu Ser Leu Gln His Pro 
        515                 520                 525             


Pro Ser Thr Ala Pro Pro Val Pro Leu Leu Arg Ser His Ser Met Pro 
    530                 535                 540                 


Ser Ala Ala Cys Thr Ile Ser Thr Pro His His Pro Phe Arg Gly Ser 
545                 550                 555                 560 


Tyr Ser Phe Asp Asp His Ile Thr Asp Ser Glu Ala Leu Ser His Ser 
                565                 570                 575     


Ser His Val Phe Thr Ser His Pro Arg Met Leu Lys Arg Gln Pro Ala 
            580                 585                 590         


Ile Glu Leu Pro Leu Gly Gly Glu Tyr Ser Ser Glu Glu Pro Gly Pro 
        595                 600                 605             


Ser Ser Lys Asp Thr Ala Ser Lys Pro Ser Asp Glu Val Glu Pro Lys 
    610                 615                 620                 


Glu Ser Glu Leu Thr Lys Lys Thr Lys Lys Gly Leu Lys Thr Lys Gly 
625                 630                 635                 640 


Val Ile Tyr Glu Cys Asn Ile Cys Gly Ala Arg Tyr Lys Lys Arg Asp 
                645                 650                 655     


Asn Tyr Glu Ala His Lys Lys Tyr Tyr Cys Ser Glu Leu Gln Ile Ala 
            660                 665                 670         


Lys Pro Ile Ser Ala Gly Thr His Thr Ser Pro Glu Ala Glu Lys Ser 
        675                 680                 685             


Gln Ile Glu His Glu Pro Trp Ser Gln Met Met His Tyr Lys Leu Gly 
    690                 695                 700                 


Thr Thr Leu Glu Leu Thr Pro Leu Arg Lys Arg Arg Lys Glu Lys Ser 
705                 710                 715                 720 


Leu Gly Asp Glu Glu Glu Pro Pro Ala Phe Glu Ser Thr Lys Ser Gln 
                725                 730                 735     


Phe Gly Ser Pro Gly Pro Ser Asp Ala Ala Arg Asn Leu Pro Leu Glu 
            740                 745                 750         


Ser Thr Lys Ser Pro Ala Glu Pro Ser Lys Ser Val Pro Ser Leu Glu 
        755                 760                 765             


Gly Pro Thr Gly Phe Gln Pro Arg Thr Pro Lys Pro Gly Ser Gly Ser 
    770                 775                 780                 


Glu Ser Gly Lys Glu Arg Arg Thr Thr Ser Lys Glu Ile Ser Val Ile 
785                 790                 795                 800 


Gln His Thr Ser Ser Phe Glu Lys Ser Asp Ser Leu Glu Gln Pro Ser 
                805                 810                 815     


Gly Leu Glu Gly Glu Asp Lys Pro Leu Ala Gln Phe Pro Ser Pro Pro 
            820                 825                 830         


Pro Ala Pro His Gly Arg Ser Ala His Ser Leu Gln Pro Lys Leu Val 
        835                 840                 845             


Arg Gln Pro Asn Ile Gln Val Pro Glu Ile Leu Val Thr Glu Glu Pro 
    850                 855                 860                 


Asp Arg Pro Asp Thr Glu Pro Glu Pro Pro Pro Lys Glu Pro Glu Lys 
865                 870                 875                 880 


Thr Glu Glu Phe Gln Trp Pro Gln Arg Ser Gln Thr Leu Ala Gln Leu 
                885                 890                 895     


Pro Ala Glu Lys Leu Pro Pro Lys Lys Lys Arg Leu Arg Leu Ala Glu 
            900                 905                 910         


Met Ala Gln Ser Ser Gly Glu Ser Ser Phe Glu Ser Ser Val Pro Leu 
        915                 920                 925             


Ser Arg Ser Pro Ser Gln Glu Ser Asn Val Ser Leu Ser Gly Ser Ser 
    930                 935                 940                 


Arg Ser Ala Ser Phe Glu Arg Asp Asp His Gly Lys Ala Glu Ala Pro 
945                 950                 955                 960 


Ser Pro Ser Ser Asp Met Arg Pro Lys Pro Leu Gly Thr His Met Leu 
                965                 970                 975     


Thr Val Pro Ser His His Pro His Ala Arg Glu Met Arg Arg Ser Ala 
            980                 985                 990         


Ser Glu Gln Ser Pro Asn Val Ser  His Ser Ala His Met  Thr Glu Thr 
        995                 1000                 1005             


Arg Ser  Lys Ser Phe Asp Tyr  Gly Ser Leu Ser Leu  Thr Gly Pro 
    1010                 1015                 1020             


Ser Ala  Pro Ala Pro Val Ala  Pro Pro Ala Arg Val  Ala Pro Pro 
    1025                 1030                 1035             


Glu Arg  Arg Lys Cys Phe Leu  Val Arg Gln Ala Ser  Leu Ser Arg 
    1040                 1045                 1050             


Pro Pro  Glu Ser Glu Leu Glu  Val Ala Pro Lys Gly  Arg Gln Glu 
    1055                 1060                 1065             


Ser Glu  Glu Pro Gln Pro Ser  Ser Ser Lys Pro Ser  Ala Lys Ser 
    1070                 1075                 1080             


Ser Leu  Ser Gln Ile Ser Ser  Ala Ala Thr Ser His  Gly Gly Pro 
    1085                 1090                 1095             


Pro Gly  Gly Lys Gly Pro Gly  Gln Asp Arg Pro Pro  Leu Gly Pro 
    1100                 1105                 1110             


Thr Val  Pro Tyr Thr Glu Ala  Leu Gln Val Phe His  His Pro Val 
    1115                 1120                 1125             


Ala Gln  Thr Pro Leu His Glu  Lys Pro Tyr Leu Pro  Pro Pro Val 
    1130                 1135                 1140             


Ser Leu  Phe Ser Phe Gln His  Leu Val Gln His Glu  Pro Gly Gln 
    1145                 1150                 1155             


Ser Pro  Glu Phe Phe Ser Thr  Gln Ala Met Ser Ser  Leu Leu Ser 
    1160                 1165                 1170             


Ser Pro  Tyr Ser Met Pro Pro  Leu Pro Pro Ser Leu  Phe Gln Ala 
    1175                 1180                 1185             


Pro Pro  Leu Pro Leu Gln Pro  Thr Val Leu His Pro  Gly Gln Leu 
    1190                 1195                 1200             


His Leu  Pro Gln Leu Met Pro  His Pro Ala Asn Ile  Pro Phe Arg 
    1205                 1210                 1215             


Gln Pro  Pro Ser Phe Leu Pro  Met Pro Tyr Pro Thr  Ser Ser Ala 
    1220                 1225                 1230             


Leu Ser  Ser Gly Phe Phe Leu  Pro Leu Gln Ser Gln  Phe Ala Leu 
    1235                 1240                 1245             


Gln Leu  Pro Gly Asp Val Glu  Ser His Leu Pro Gln  Ile Lys Thr 
    1250                 1255                 1260             


Ser Leu  Ala Pro Leu Ala Thr  Gly Ser Ala Gly Leu  Ser Pro Ser 
    1265                 1270                 1275             


Thr Glu  Tyr Ser Ser Asp Ile  Arg Leu Pro Pro Val  Ala Pro Pro 
    1280                 1285                 1290             


Ala Ser  Ser Ser Ala Pro Thr  Ser Ala Pro Pro Leu  Ala Leu Pro 
    1295                 1300                 1305             


Ala Cys  Pro Asp Thr Met Val  Ser Leu Val Val Pro  Val Arg Val 
    1310                 1315                 1320             


Gln Thr  Asn Met Pro Ser Tyr  Gly Ser Ala Met Tyr  Thr Thr Leu 
    1325                 1330                 1335             


Ser Gln  Ile Leu Val Thr Gln  Ser Gln Gly Ser Ser  Ala Thr Val 
    1340                 1345                 1350             


Ala Leu  Pro Lys Phe Glu Glu  Pro Pro Ser Lys Gly  Thr Thr Val 
    1355                 1360                 1365             


Cys Gly  Ala Asp Val His Glu  Val Gly Pro Gly Pro  Ser Gly Leu 
    1370                 1375                 1380             


Ser Glu  Glu Gln Ser Arg Ala  Phe Pro Thr Pro Tyr  Leu Arg Val 
    1385                 1390                 1395             


Pro Val  Thr Leu Pro Glu Arg  Lys Gly Thr Ser Leu  Ser Ser Glu 
    1400                 1405                 1410             


Ser Ile  Leu Ser Leu Glu Gly  Ser Ser Ser Thr Ala  Gly Gly Ser 
    1415                 1420                 1425             


Lys Arg  Val Leu Ser Pro Ala  Gly Ser Leu Glu Leu  Thr Met Glu 
    1430                 1435                 1440             


Thr Gln  Gln Gln Lys Arg Val  Lys Glu Glu Glu Ala  Ser Lys Ala 
    1445                 1450                 1455             


Asp Glu  Lys Leu Glu Leu Val  Lys Pro Cys Ser Val  Val Leu Thr 
    1460                 1465                 1470             


Ser Thr  Glu Asp Gly Lys Arg  Pro Glu Lys Ser His  Leu Gly Asn 
    1475                 1480                 1485             


Gln Gly  Gln Gly Arg Arg Glu  Leu Glu Met Leu Ser  Ser Leu Ser 
    1490                 1495                 1500             


Ser Asp  Pro Ser Asp Thr Lys  Glu Ile Pro Pro Leu  Pro His Pro 
    1505                 1510                 1515             


Ala Leu  Ser His Gly Thr Ala  Pro Gly Ser Glu Ala  Leu Lys Glu 
    1520                 1525                 1530             


Tyr Pro  Gln Pro Ser Gly Lys  Pro His Arg Arg Gly  Leu Thr Pro 
    1535                 1540                 1545             


Leu Ser  Val Lys Lys Glu Asp  Ser Lys Glu Gln Pro  Asp Leu Pro 
    1550                 1555                 1560             


Ser Leu  Ala Pro Pro Ser Ser  Leu Pro Leu Ser Glu  Thr Ser Ser 
    1565                 1570                 1575             


Arg Pro  Ala Lys Ser Gln Glu  Gly Thr Asp Ser Lys  Lys Val Leu 
    1580                 1585                 1590             


Gln Phe  Pro Ser Leu His Thr  Thr Thr Asn Val Ser  Trp Cys Tyr 
    1595                 1600                 1605             


Leu Asn  Tyr Ile Lys Pro Asn  His Ile Gln His Ala  Asp Arg Arg 
    1610                 1615                 1620             


Ser Ser  Val Tyr Ala Gly Trp  Cys Ile Ser Leu Tyr  Asn Pro Asn 
    1625                 1630                 1635             


Leu Pro  Gly Val Ser Thr Lys  Ala Ala Leu Ser Leu  Leu Arg Ser 
    1640                 1645                 1650             


Lys Gln  Lys Val Ser Lys Glu  Thr Tyr Thr Met Ala  Thr Ala Pro 
    1655                 1660                 1665             


His Pro  Glu Ala Gly Arg Leu  Val Pro Ser Ser Ser  Arg Lys Pro 
    1670                 1675                 1680             


Arg Met  Thr Glu Val His Leu  Pro Ser Leu Val Ser  Pro Glu Gly 
    1685                 1690                 1695             


Gln Lys  Asp Leu Ala Arg Val  Glu Lys Glu Glu Glu  Arg Arg Gly 
    1700                 1705                 1710             


Glu Pro  Glu Glu Asp Ala Pro  Ala Ser Gln Arg Gly  Glu Pro Ala 
    1715                 1720                 1725             


Arg Ile  Lys Ile Phe Glu Gly  Gly Tyr Lys Ser Asn  Glu Glu Tyr 
    1730                 1735                 1740             


Val Tyr  Val Arg Gly Arg Gly  Arg Gly Lys Tyr Val  Cys Glu Glu 
    1745                 1750                 1755             


Cys Gly  Ile Arg Cys Lys Lys  Pro Ser Met Leu Lys  Lys His Ile 
    1760                 1765                 1770             


Arg Thr  His Thr Asp Val Arg  Pro Tyr Val Cys Lys  His Cys His 
    1775                 1780                 1785             


Phe Ala  Phe Lys Thr Lys Gly  Asn Leu Thr Lys His  Met Lys Ser 
    1790                 1795                 1800             


Lys Ala  His Ser Lys Lys Cys  Gln Glu Thr Gly Val  Leu Glu Glu 
    1805                 1810                 1815             


Leu Glu  Ala Glu Glu Gly Thr  Ser Asp Asp Leu Phe  Gln Asp Ser 
    1820                 1825                 1830             


Glu Gly  Arg Glu Gly Ser Glu  Ala Val Glu Glu His  Gln Phe Ser 
    1835                 1840                 1845             


Asp Leu  Glu Asp Ser Asp Ser  Asp Ser Asp Leu Asp  Glu Asp Glu 
    1850                 1855                 1860             


Asp Glu  Asp Glu Glu Glu Ser  Gln Asp Glu Leu Ser  Arg Pro Ser 
    1865                 1870                 1875             


Ser Glu  Ala Pro Pro Pro Gly  Pro Pro His Ala Leu  Arg Ala Asp 
    1880                 1885                 1890             


Ser Ser  Pro Ile Leu Gly Pro  Gln Pro Pro Asp Ala  Pro Ala Ser 
    1895                 1900                 1905             


Gly Thr  Glu Ala Thr Arg Gly  Ser Ser Val Ser Glu  Ala Glu Arg 
    1910                 1915                 1920             


Leu Thr  Ala Ser Ser Cys Ser  Met Ser Ser Gln Ser  Met Pro Gly 
    1925                 1930                 1935             


Leu Pro  Trp Leu Gly Pro Ala  Pro Leu Gly Ser Val  Glu Lys Asp 
    1940                 1945                 1950             


Thr Gly  Ser Ala Leu Ser Tyr  Lys Pro Val Ser Pro  Arg Arg Pro 
    1955                 1960                 1965             


Trp Ser  Pro Ser Lys Glu Ala  Gly Ser Arg Pro Pro  Leu Ala Arg 
    1970                 1975                 1980             


Lys His  Ser Leu Thr Lys Asn  Asp Ser Ser Pro Gln  Arg Cys Ser 
    1985                 1990                 1995             


Pro Ala  Arg Glu Pro Gln Ala  Ser Ala Pro Ser Pro  Pro Gly Leu 
    2000                 2005                 2010             


His Val  Asp Pro Gly Arg Gly  Met Gly Ala Leu Pro  Cys Gly Ser 
    2015                 2020                 2025             


Pro Arg  Leu Gln Leu Ser Pro  Leu Thr Leu Cys Pro  Leu Gly Arg 
    2030                 2035                 2040             


Glu Leu  Ala Pro Arg Ala His  Val Leu Ser Lys Leu  Glu Gly Thr 
    2045                 2050                 2055             


Thr Asp  Pro Gly Leu Pro Arg  Tyr Ser Pro Thr Arg  Arg Trp Ser 
    2060                 2065                 2070             


Pro Gly  Gln Ala Glu Ser Pro  Pro Arg Ser Ala Pro  Pro Gly Lys 
    2075                 2080                 2085             


Trp Ala  Leu Ala Gly Pro Gly  Ser Pro Ser Ala Gly  Glu His Gly 
    2090                 2095                 2100             


Pro Gly  Leu Gly Leu Asp Pro  Arg Val Leu Phe Pro  Pro Ala Pro 
    2105                 2110                 2115             


Leu Pro  His Lys Leu Leu Ser  Arg Ser Pro Glu Thr  Cys Ala Ser 
    2120                 2125                 2130             


Pro Trp  Gln Lys Ala Glu Ser  Arg Ser Pro Ser Cys  Ser Pro Gly 
    2135                 2140                 2145             


Pro Ala  His Pro Leu Ser Ser  Arg Pro Phe Ser Ala  Leu His Asp 
    2150                 2155                 2160             


Phe His  Gly His Ile Leu Ala  Arg Thr Glu Glu Asn  Ile Phe Ser 
    2165                 2170                 2175             


His Leu  Pro Leu His Ser Gln  His Leu Thr Arg Ala  Pro Cys Pro 
    2180                 2185                 2190             


Leu Ile  Pro Ile Gly Gly Ile  Gln Met Val Gln Ala  Arg Pro Gly 
    2195                 2200                 2205             


Ala His  Pro Thr Leu Leu Pro  Gly Pro Thr Ala Ala  Trp Val Ser 
    2210                 2215                 2220             


Gly Phe  Ser Gly Gly Gly Ser  Asp Leu Thr Gly Ala  Arg Glu Ala 
    2225                 2230                 2235             


Gln Glu  Arg Gly Arg Trp Ser  Pro Thr Glu Ser Ser  Ser Ala Ser 
    2240                 2245                 2250             


Val Ser  Pro Val Ala Lys Val  Ser Lys Phe Thr Leu  Ser Ser Glu 
    2255                 2260                 2265             


Leu Glu  Gly Gly Asp Tyr Pro  Lys Glu Arg Glu Arg  Thr Gly Gly 
    2270                 2275                 2280             


Gly Pro  Gly Arg Pro Pro Asp  Trp Thr Pro His Gly  Thr Gly Ala 
    2285                 2290                 2295             


Pro Ala  Glu Pro Thr Pro Thr  His Ser Pro Cys Thr  Pro Pro Asp 
    2300                 2305                 2310             


Thr Leu  Pro Arg Pro Pro Gln  Gly Arg Arg Ala Ala  Gln Ser Trp 
    2315                 2320                 2325             


Ser Pro  Arg Leu Glu Ser Pro  Arg Ala Pro Thr Asn  Pro Glu Pro 
    2330                 2335                 2340             


Ser Ala  Thr Pro Pro Leu Asp  Arg Ser Ser Ser Val  Gly Cys Leu 
    2345                 2350                 2355             


Ala Glu  Ala Ser Ala Arg Phe  Pro Ala Arg Thr Arg  Asn Leu Ser 
    2360                 2365                 2370             


Gly Glu  Pro Arg Thr Arg Gln  Asp Ser Pro Lys Pro  Ser Gly Ser 
    2375                 2380                 2385             


Gly Glu  Pro Arg Ala His Pro  His Gln Pro Glu Asp  Arg Val Pro 
    2390                 2395                 2400             


Pro Asn  Ala 
    2405     


<210>  772
<211>  2405
<212>  PRT
<213>  Homo sapiens

<400>  772

Met Asp Pro Glu Gln Ser Val Lys Gly Thr Lys Lys Ala Glu Gly Ser 
1               5                   10                  15      


Pro Arg Lys Arg Leu Thr Lys Gly Glu Ala Ile Gln Thr Ser Val Ser 
            20                  25                  30          


Ser Ser Val Pro Tyr Pro Gly Ser Gly Thr Ala Ala Thr Gln Glu Ser 
        35                  40                  45              


Pro Ala Gln Glu Leu Leu Ala Pro Gln Pro Phe Pro Gly Pro Ser Ser 
    50                  55                  60                  


Val Leu Arg Glu Gly Ser Gln Glu Lys Thr Gly Gln Gln Gln Lys Pro 
65                  70                  75                  80  


Pro Lys Arg Pro Pro Ile Glu Ala Ser Val His Ile Ser Gln Leu Pro 
                85                  90                  95      


Gln His Pro Leu Thr Pro Ala Phe Met Ser Pro Gly Lys Pro Glu His 
            100                 105                 110         


Leu Leu Glu Gly Ser Thr Trp Gln Leu Val Asp Pro Met Arg Pro Gly 
        115                 120                 125             


Pro Ser Gly Ser Phe Val Ala Pro Gly Leu His Pro Gln Ser Gln Leu 
    130                 135                 140                 


Leu Pro Ser His Ala Ser Ile Ile Pro Pro Glu Asp Leu Pro Gly Val 
145                 150                 155                 160 


Pro Lys Val Phe Val Pro Arg Pro Ser Gln Val Ser Leu Lys Pro Thr 
                165                 170                 175     


Glu Glu Ala His Lys Lys Glu Arg Lys Pro Gln Lys Pro Gly Lys Tyr 
            180                 185                 190         


Ile Cys Gln Tyr Cys Ser Arg Pro Cys Ala Lys Pro Ser Val Leu Gln 
        195                 200                 205             


Lys His Ile Arg Ser His Thr Gly Glu Arg Pro Tyr Pro Cys Gly Pro 
    210                 215                 220                 


Cys Gly Phe Ser Phe Lys Thr Lys Ser Asn Leu Tyr Lys His Arg Lys 
225                 230                 235                 240 


Ser His Ala His Arg Ile Lys Ala Gly Leu Ala Ser Gly Met Gly Gly 
                245                 250                 255     


Glu Met Tyr Pro His Gly Leu Glu Met Glu Arg Ile Pro Gly Glu Glu 
            260                 265                 270         


Phe Glu Glu Pro Thr Glu Gly Glu Ser Thr Asp Ser Glu Glu Glu Thr 
        275                 280                 285             


Ser Ala Thr Ser Gly His Pro Ala Glu Leu Ser Pro Arg Pro Lys Gln 
    290                 295                 300                 


Pro Leu Leu Ser Ser Gly Leu Tyr Ser Ser Gly Ser His Ser Ser Ser 
305                 310                 315                 320 


His Glu Arg Cys Ser Leu Ser Gln Ser Ser Thr Ala Gln Ser Leu Glu 
                325                 330                 335     


Asp Pro Pro Pro Phe Val Glu Pro Ser Ser Glu His Pro Leu Ser His 
            340                 345                 350         


Lys Pro Glu Asp Thr His Thr Ile Lys Gln Lys Leu Ala Leu Arg Leu 
        355                 360                 365             


Ser Glu Arg Lys Lys Val Ile Asp Glu Gln Ala Phe Leu Ser Pro Gly 
    370                 375                 380                 


Ser Lys Gly Ser Thr Glu Ser Gly Tyr Phe Ser Arg Ser Glu Ser Ala 
385                 390                 395                 400 


Glu Gln Gln Val Ser Pro Pro Asn Thr Asn Ala Lys Ser Tyr Ala Glu 
                405                 410                 415     


Ile Ile Phe Gly Lys Cys Gly Arg Ile Gly Gln Arg Thr Ala Met Leu 
            420                 425                 430         


Thr Ala Thr Ser Thr Gln Pro Leu Leu Pro Leu Ser Thr Glu Asp Lys 
        435                 440                 445             


Pro Ser Leu Val Pro Leu Ser Val Pro Arg Thr Gln Val Ile Glu His 
    450                 455                 460                 


Ile Thr Lys Leu Ile Thr Ile Asn Glu Ala Val Val Asp Thr Ser Glu 
465                 470                 475                 480 


Ile Asp Ser Val Lys Pro Arg Arg Ser Ser Leu Ser Arg Arg Ser Ser 
                485                 490                 495     


Met Glu Ser Pro Lys Ser Ser Leu Tyr Arg Glu Pro Leu Ser Ser His 
            500                 505                 510         


Ser Glu Lys Thr Lys Pro Glu Gln Ser Leu Leu Ser Leu Gln His Pro 
        515                 520                 525             


Pro Ser Thr Ala Pro Pro Val Pro Leu Leu Arg Ser His Ser Met Pro 
    530                 535                 540                 


Ser Ala Ala Cys Thr Ile Ser Thr Pro His His Pro Phe Arg Gly Ser 
545                 550                 555                 560 


Tyr Ser Phe Asp Asp His Ile Thr Asp Ser Glu Ala Leu Ser His Ser 
                565                 570                 575     


Ser His Val Phe Thr Ser His Pro Arg Met Leu Lys Arg Gln Pro Ala 
            580                 585                 590         


Ile Glu Leu Pro Leu Gly Gly Glu Tyr Ser Ser Glu Glu Pro Gly Pro 
        595                 600                 605             


Ser Ser Lys Asp Thr Ala Ser Lys Pro Ser Asp Glu Val Glu Pro Lys 
    610                 615                 620                 


Glu Ser Glu Leu Thr Lys Lys Thr Lys Lys Gly Leu Lys Thr Lys Gly 
625                 630                 635                 640 


Val Ile Tyr Glu Cys Asn Ile Cys Gly Ala Arg Tyr Lys Lys Arg Asp 
                645                 650                 655     


Asn Tyr Glu Ala His Lys Lys Tyr Tyr Cys Ser Glu Leu Gln Ile Ala 
            660                 665                 670         


Lys Pro Ile Ser Ala Gly Thr His Thr Ser Pro Glu Ala Glu Lys Ser 
        675                 680                 685             


Gln Ile Glu His Glu Pro Trp Ser Gln Met Met His Tyr Lys Leu Gly 
    690                 695                 700                 


Thr Thr Leu Glu Leu Thr Pro Leu Arg Lys Arg Arg Lys Glu Lys Ser 
705                 710                 715                 720 


Leu Gly Asp Glu Glu Glu Pro Pro Ala Phe Glu Ser Thr Lys Ser Gln 
                725                 730                 735     


Phe Gly Ser Pro Gly Pro Ser Asp Ala Ala Arg Asn Leu Pro Leu Glu 
            740                 745                 750         


Ser Thr Lys Ser Pro Ala Glu Pro Ser Lys Ser Val Pro Ser Leu Glu 
        755                 760                 765             


Gly Pro Thr Gly Phe Gln Pro Arg Thr Pro Lys Pro Gly Ser Gly Ser 
    770                 775                 780                 


Glu Ser Gly Lys Glu Arg Arg Thr Thr Ser Lys Glu Ile Ser Val Ile 
785                 790                 795                 800 


Gln His Thr Ser Ser Phe Glu Lys Ser Asp Ser Leu Glu Gln Pro Ser 
                805                 810                 815     


Gly Leu Glu Gly Glu Asp Lys Pro Leu Ala Gln Phe Pro Ser Pro Pro 
            820                 825                 830         


Pro Ala Pro His Gly Arg Ser Ala His Ser Leu Gln Pro Lys Leu Val 
        835                 840                 845             


Arg Gln Pro Asn Ile Gln Val Pro Glu Ile Leu Val Thr Glu Glu Pro 
    850                 855                 860                 


Asp Arg Pro Asp Thr Glu Pro Glu Pro Pro Pro Lys Glu Pro Glu Lys 
865                 870                 875                 880 


Thr Glu Glu Phe Gln Trp Pro Gln Arg Ser Gln Thr Leu Ala Gln Leu 
                885                 890                 895     


Pro Ala Glu Lys Leu Pro Pro Lys Lys Lys Arg Leu Arg Leu Ala Glu 
            900                 905                 910         


Met Ala Gln Ser Ser Gly Glu Ser Ser Phe Glu Ser Ser Val Pro Leu 
        915                 920                 925             


Ser Arg Ser Pro Ser Gln Glu Ser Asn Val Ser Leu Ser Gly Ser Ser 
    930                 935                 940                 


Arg Ser Ala Ser Phe Glu Arg Asp Asp His Gly Lys Ala Glu Ala Pro 
945                 950                 955                 960 


Ser Pro Ser Ser Asp Met Arg Pro Lys Pro Leu Gly Thr His Met Leu 
                965                 970                 975     


Thr Val Pro Ser His His Pro His Ala Arg Glu Met Arg Arg Ser Ala 
            980                 985                 990         


Ser Glu Gln Ser Pro Asn Val Ser  His Ser Ala His Met  Thr Glu Thr 
        995                 1000                 1005             


Arg Ser  Lys Ser Phe Asp Tyr  Gly Ser Leu Ser Leu  Thr Gly Pro 
    1010                 1015                 1020             


Ser Ala  Pro Ala Pro Val Ala  Pro Pro Ala Arg Val  Ala Pro Pro 
    1025                 1030                 1035             


Glu Arg  Arg Lys Cys Phe Leu  Val Arg Gln Ala Ser  Leu Ser Arg 
    1040                 1045                 1050             


Pro Pro  Glu Ser Glu Leu Glu  Val Ala Pro Lys Gly  Arg Gln Glu 
    1055                 1060                 1065             


Ser Glu  Glu Pro Gln Pro Ser  Ser Ser Lys Pro Ser  Ala Lys Ser 
    1070                 1075                 1080             


Ser Leu  Ser Gln Ile Ser Ser  Ala Ala Thr Ser His  Gly Gly Pro 
    1085                 1090                 1095             


Pro Gly  Gly Lys Gly Pro Gly  Gln Asp Arg Pro Pro  Leu Gly Pro 
    1100                 1105                 1110             


Thr Val  Pro Tyr Thr Glu Ala  Leu Gln Val Phe His  His Pro Val 
    1115                 1120                 1125             


Ala Gln  Thr Pro Leu His Glu  Lys Pro Tyr Leu Pro  Pro Pro Val 
    1130                 1135                 1140             


Ser Leu  Phe Ser Phe Gln His  Leu Val Gln His Glu  Pro Gly Gln 
    1145                 1150                 1155             


Ser Pro  Glu Phe Phe Ser Thr  Gln Ala Met Ser Ser  Leu Leu Ser 
    1160                 1165                 1170             


Ser Pro  Tyr Ser Met Pro Pro  Leu Pro Pro Ser Leu  Phe Gln Ala 
    1175                 1180                 1185             


Pro Pro  Leu Pro Leu Gln Pro  Thr Val Leu His Pro  Gly Gln Leu 
    1190                 1195                 1200             


His Leu  Pro Gln Leu Met Pro  His Pro Ala Asn Ile  Pro Phe Arg 
    1205                 1210                 1215             


Gln Pro  Pro Ser Phe Leu Pro  Met Pro Tyr Pro Thr  Ser Ser Ala 
    1220                 1225                 1230             


Leu Ser  Ser Gly Phe Phe Leu  Pro Leu Gln Ser Gln  Phe Ala Leu 
    1235                 1240                 1245             


Gln Leu  Pro Gly Asp Val Glu  Ser His Leu Pro Gln  Ile Lys Thr 
    1250                 1255                 1260             


Ser Leu  Ala Pro Leu Ala Thr  Gly Ser Ala Gly Leu  Ser Pro Ser 
    1265                 1270                 1275             


Thr Glu  Tyr Ser Ser Asp Ile  Arg Leu Pro Pro Val  Ala Pro Pro 
    1280                 1285                 1290             


Ala Ser  Ser Ser Ala Pro Thr  Ser Ala Pro Pro Leu  Ala Leu Pro 
    1295                 1300                 1305             


Ala Cys  Pro Asp Thr Met Val  Ser Leu Val Val Pro  Val Arg Val 
    1310                 1315                 1320             


Gln Thr  Asn Met Pro Ser Tyr  Gly Ser Ala Met Tyr  Thr Thr Leu 
    1325                 1330                 1335             


Ser Gln  Ile Leu Val Thr Gln  Ser Gln Gly Ser Ser  Ala Thr Val 
    1340                 1345                 1350             


Ala Leu  Pro Lys Phe Glu Glu  Pro Pro Ser Lys Gly  Thr Thr Val 
    1355                 1360                 1365             


Cys Gly  Ala Asp Val His Glu  Val Gly Pro Gly Pro  Ser Gly Leu 
    1370                 1375                 1380             


Ser Glu  Glu Gln Ser Arg Ala  Phe Pro Thr Pro Tyr  Leu Arg Val 
    1385                 1390                 1395             


Pro Val  Thr Leu Pro Glu Arg  Lys Gly Thr Ser Leu  Ser Ser Glu 
    1400                 1405                 1410             


Ser Ile  Leu Ser Leu Glu Gly  Ser Ser Ser Thr Ala  Gly Gly Ser 
    1415                 1420                 1425             


Lys Arg  Val Leu Ser Pro Ala  Gly Ser Leu Glu Leu  Thr Met Glu 
    1430                 1435                 1440             


Thr Gln  Gln Gln Lys Arg Val  Lys Glu Glu Glu Ala  Ser Lys Ala 
    1445                 1450                 1455             


Asp Glu  Lys Leu Glu Leu Val  Lys Pro Cys Ser Val  Val Leu Thr 
    1460                 1465                 1470             


Ser Thr  Glu Asp Gly Lys Arg  Pro Glu Lys Ser His  Leu Gly Asn 
    1475                 1480                 1485             


Gln Gly  Gln Gly Arg Arg Glu  Leu Glu Met Leu Ser  Ser Leu Ser 
    1490                 1495                 1500             


Ser Asp  Pro Ser Asp Thr Lys  Glu Ile Pro Pro Leu  Pro His Pro 
    1505                 1510                 1515             


Ala Leu  Ser His Gly Thr Ala  Pro Gly Ser Glu Ala  Leu Lys Glu 
    1520                 1525                 1530             


Tyr Pro  Gln Pro Ser Gly Lys  Pro His Arg Arg Gly  Leu Thr Pro 
    1535                 1540                 1545             


Leu Ser  Val Lys Lys Glu Asp  Ser Lys Glu Gln Pro  Asp Leu Pro 
    1550                 1555                 1560             


Ser Leu  Ala Pro Pro Ser Ser  Leu Pro Leu Ser Glu  Thr Ser Ser 
    1565                 1570                 1575             


Arg Pro  Ala Lys Ser Gln Glu  Gly Thr Asp Ser Lys  Lys Val Leu 
    1580                 1585                 1590             


Gln Phe  Pro Ser Leu His Thr  Thr Thr Asn Val Ser  Trp Cys Tyr 
    1595                 1600                 1605             


Leu Asn  Tyr Ile Lys Pro Asn  His Ile Gln His Ala  Asp Arg Arg 
    1610                 1615                 1620             


Ser Ser  Val Tyr Ala Gly Trp  Cys Ile Ser Leu Tyr  Asn Pro Asn 
    1625                 1630                 1635             


Leu Pro  Gly Val Ser Thr Lys  Ala Ala Leu Ser Leu  Leu Arg Ser 
    1640                 1645                 1650             


Lys Gln  Lys Val Ser Lys Glu  Thr Tyr Thr Met Ala  Thr Ala Pro 
    1655                 1660                 1665             


His Pro  Glu Ala Gly Arg Leu  Val Pro Ser Ser Ser  Arg Lys Pro 
    1670                 1675                 1680             


Arg Met  Thr Glu Val His Leu  Pro Ser Leu Val Ser  Pro Glu Gly 
    1685                 1690                 1695             


Gln Lys  Asp Leu Ala Arg Val  Glu Lys Glu Glu Glu  Arg Arg Gly 
    1700                 1705                 1710             


Glu Pro  Glu Glu Asp Ala Pro  Ala Ser Gln Arg Gly  Glu Pro Ala 
    1715                 1720                 1725             


Arg Ile  Lys Ile Phe Glu Gly  Gly Tyr Lys Ser Asn  Glu Glu Tyr 
    1730                 1735                 1740             


Val Tyr  Val Arg Gly Arg Gly  Arg Gly Lys Tyr Val  Cys Glu Glu 
    1745                 1750                 1755             


Cys Gly  Ile Arg Cys Lys Lys  Pro Ser Met Leu Lys  Lys His Ile 
    1760                 1765                 1770             


Arg Thr  His Thr Asp Val Arg  Pro Tyr Val Cys Lys  His Cys His 
    1775                 1780                 1785             


Phe Ala  Phe Lys Thr Lys Gly  Asn Leu Thr Lys His  Met Lys Ser 
    1790                 1795                 1800             


Lys Ala  His Ser Lys Lys Cys  Gln Glu Thr Gly Val  Leu Glu Glu 
    1805                 1810                 1815             


Leu Glu  Ala Glu Glu Gly Thr  Ser Asp Asp Leu Phe  Gln Asp Ser 
    1820                 1825                 1830             


Glu Gly  Arg Glu Gly Ser Glu  Ala Val Glu Glu His  Gln Phe Ser 
    1835                 1840                 1845             


Asp Leu  Glu Asp Ser Asp Ser  Asp Ser Asp Leu Asp  Glu Asp Glu 
    1850                 1855                 1860             


Asp Glu  Asp Glu Glu Glu Ser  Gln Asp Glu Leu Ser  Arg Pro Ser 
    1865                 1870                 1875             


Ser Glu  Ala Pro Pro Pro Gly  Pro Pro His Ala Leu  Arg Ala Asp 
    1880                 1885                 1890             


Ser Ser  Pro Ile Leu Gly Pro  Gln Pro Pro Asp Ala  Pro Ala Ser 
    1895                 1900                 1905             


Gly Thr  Glu Ala Thr Arg Gly  Ser Ser Val Ser Glu  Ala Glu Arg 
    1910                 1915                 1920             


Leu Thr  Ala Ser Ser Cys Ser  Met Ser Ser Gln Ser  Met Pro Gly 
    1925                 1930                 1935             


Leu Pro  Trp Leu Gly Pro Ala  Pro Leu Gly Ser Val  Glu Lys Asp 
    1940                 1945                 1950             


Thr Gly  Ser Ala Leu Ser Tyr  Lys Pro Val Ser Pro  Arg Arg Pro 
    1955                 1960                 1965             


Trp Ser  Pro Ser Lys Glu Ala  Gly Ser Arg Pro Pro  Leu Ala Arg 
    1970                 1975                 1980             


Lys His  Ser Leu Thr Lys Asn  Asp Ser Ser Pro Gln  Arg Cys Ser 
    1985                 1990                 1995             


Pro Ala  Arg Glu Pro Gln Ala  Ser Ala Pro Ser Pro  Pro Gly Leu 
    2000                 2005                 2010             


His Val  Asp Pro Gly Arg Gly  Met Gly Ala Leu Pro  Cys Gly Ser 
    2015                 2020                 2025             


Pro Arg  Leu Gln Leu Ser Pro  Leu Thr Leu Cys Pro  Leu Gly Arg 
    2030                 2035                 2040             


Glu Leu  Ala Pro Arg Ala His  Val Leu Ser Lys Leu  Glu Gly Thr 
    2045                 2050                 2055             


Thr Asp  Pro Gly Leu Pro Arg  Tyr Ser Pro Thr Arg  Arg Trp Ser 
    2060                 2065                 2070             


Pro Gly  Gln Ala Glu Ser Pro  Pro Arg Ser Ala Pro  Pro Gly Lys 
    2075                 2080                 2085             


Trp Ala  Leu Ala Gly Pro Gly  Ser Pro Ser Ala Gly  Glu His Gly 
    2090                 2095                 2100             


Pro Gly  Leu Gly Leu Asp Pro  Arg Val Leu Phe Pro  Pro Ala Pro 
    2105                 2110                 2115             


Leu Pro  His Lys Leu Leu Ser  Arg Ser Pro Glu Thr  Cys Ala Ser 
    2120                 2125                 2130             


Pro Trp  Lys Ala Glu Ser Arg  Ser Pro Ser Cys Ser  Pro Gly Pro 
    2135                 2140                 2145             


Ala His  Pro Leu Ser Ser Arg  Pro Phe Ser Ala Leu  His Asp Phe 
    2150                 2155                 2160             


His Gly  His Ile Leu Ala Arg  Thr Glu Glu Asn Ile  Phe Ser His 
    2165                 2170                 2175             


Leu Pro  Leu His Ser Gln His  Leu Thr Arg Ala Pro  Cys Pro Leu 
    2180                 2185                 2190             


Ile Pro  Ile Gly Gly Ile Gln  Met Val Gln Ala Arg  Pro Gly Ala 
    2195                 2200                 2205             


His Pro  Thr Leu Leu Pro Gly  Pro Thr Ala Ala Trp  Val Ser Gly 
    2210                 2215                 2220             


Phe Ser  Gly Gly Gly Ser Asp  Leu Thr Gly Ala Arg  Glu Ala Gln 
    2225                 2230                 2235             


Glu Arg  Gly Arg Trp Ser Pro  Thr Glu Ser Ser Ser  Ala Ser Val 
    2240                 2245                 2250             


Ser Pro  Val Ala Lys Val Ser  Lys Phe Thr Leu Ser  Ser Glu Leu 
    2255                 2260                 2265             


Glu Gly  Gly Asp Tyr Pro Lys  Glu Arg Glu Arg Thr  Gly Gly Gly 
    2270                 2275                 2280             


Pro Gly  Arg Pro Pro Asp Trp  Thr Pro His Gly Thr  Gly Ala Pro 
    2285                 2290                 2295             


Ala Glu  Pro Thr Pro Thr His  Ser Pro Cys Thr Pro  Pro Asp Thr 
    2300                 2305                 2310             


Leu Pro  Arg Pro Pro Gln Gly  Arg Arg Ala Ala Gln  Ser Trp Ser 
    2315                 2320                 2325             


Pro Arg  Leu Glu Ser Pro Arg  Ala Pro Thr Asn Pro  Glu Pro Ser 
    2330                 2335                 2340             


Ala Thr  Pro Pro Leu Asp Arg  Ser Ser Ser Val Gly  Cys Leu Ala 
    2345                 2350                 2355             


Glu Ala  Ser Ala Arg Phe Pro  Ala Arg Thr Arg Asn  Leu Ser Gly 
    2360                 2365                 2370             


Glu Pro  Arg Thr Arg Gln Asp  Ser Pro Lys Pro Ser  Gly Ser Gly 
    2375                 2380                 2385             


Glu Pro  Arg Ala His Pro His  Gln Pro Glu Asp Arg  Val Pro Pro 
    2390                 2395                 2400             


Asn Ala  
    2405 


<210>  773
<211>  801
<212>  PRT
<213>  Homo sapiens

<400>  773

Met Lys Thr Ser Pro Arg Arg Pro Leu Ile Leu Lys Arg Arg Arg Leu 
1               5                   10                  15      


Pro Leu Pro Val Gln Asn Ala Pro Ser Glu Thr Ser Glu Glu Glu Pro 
            20                  25                  30          


Lys Arg Ser Pro Ala Gln Gln Glu Ser Asn Gln Ala Glu Ala Ser Lys 
        35                  40                  45              


Glu Val Ala Glu Ser Asn Ser Cys Lys Phe Pro Ala Gly Ile Lys Ile 
    50                  55                  60                  


Ile Asn His Pro Thr Met Pro Asn Thr Gln Val Val Ala Ile Pro Asn 
65                  70                  75                  80  


Asn Ala Asn Ile His Ser Ile Ile Thr Ala Leu Thr Ala Lys Gly Lys 
                85                  90                  95      


Glu Ser Gly Ser Ser Gly Pro Asn Lys Phe Ile Leu Ile Ser Cys Gly 
            100                 105                 110         


Gly Ala Pro Thr Gln Pro Pro Gly Leu Arg Pro Gln Thr Gln Thr Ser 
        115                 120                 125             


Tyr Asp Ala Lys Arg Thr Glu Val Thr Leu Glu Thr Leu Gly Pro Lys 
    130                 135                 140                 


Pro Ala Ala Arg Asp Val Asn Leu Pro Arg Pro Pro Gly Ala Leu Cys 
145                 150                 155                 160 


Glu Gln Lys Arg Glu Thr Cys Ala Asp Gly Glu Ala Ala Gly Cys Thr 
                165                 170                 175     


Ile Asn Asn Ser Leu Ser Asn Ile Gln Trp Leu Arg Lys Met Ser Ser 
            180                 185                 190         


Asp Gly Leu Gly Ser Arg Ser Ile Lys Gln Glu Met Glu Glu Lys Glu 
        195                 200                 205             


Asn Cys His Leu Glu Gln Arg Gln Val Lys Val Glu Glu Pro Ser Arg 
    210                 215                 220                 


Pro Ser Ala Ser Trp Gln Asn Ser Val Ser Glu Arg Pro Pro Tyr Ser 
225                 230                 235                 240 


Tyr Met Ala Met Ile Gln Phe Ala Ile Asn Ser Thr Glu Arg Lys Arg 
                245                 250                 255     


Met Thr Leu Lys Asp Ile Tyr Thr Trp Ile Glu Asp His Phe Pro Tyr 
            260                 265                 270         


Phe Lys His Ile Ala Lys Pro Gly Trp Lys Asn Ser Ile Arg His Asn 
        275                 280                 285             


Leu Ser Leu His Asp Met Phe Val Arg Glu Thr Ser Ala Asn Gly Lys 
    290                 295                 300                 


Val Ser Phe Trp Thr Ile His Pro Ser Ala Asn Arg Tyr Leu Thr Leu 
305                 310                 315                 320 


Asp Gln Val Phe Lys Pro Leu Asp Pro Gly Ser Pro Gln Leu Pro Glu 
                325                 330                 335     


His Leu Glu Ser Gln Gln Lys Arg Pro Asn Pro Glu Leu Arg Arg Asn 
            340                 345                 350         


Met Thr Ile Lys Thr Glu Leu Pro Leu Gly Ala Arg Arg Lys Met Lys 
        355                 360                 365             


Pro Leu Leu Pro Arg Val Ser Ser Tyr Leu Val Pro Ile Gln Phe Pro 
    370                 375                 380                 


Val Asn Gln Ser Leu Val Leu Gln Pro Ser Val Lys Val Pro Leu Pro 
385                 390                 395                 400 


Leu Ala Ala Ser Leu Met Ser Ser Glu Leu Ala Arg His Ser Lys Arg 
                405                 410                 415     


Val Arg Ile Ala Pro Lys Val Phe Gly Glu Gln Val Val Phe Gly Tyr 
            420                 425                 430         


Met Ser Lys Phe Phe Ser Gly Asp Leu Arg Asp Phe Gly Thr Pro Ile 
        435                 440                 445             


Thr Ser Leu Phe Asn Phe Ile Phe Leu Cys Leu Ser Val Leu Leu Ala 
    450                 455                 460                 


Glu Glu Gly Ile Ala Pro Leu Ser Ser Ala Gly Pro Gly Lys Glu Glu 
465                 470                 475                 480 


Lys Leu Leu Phe Gly Glu Gly Phe Ser Pro Leu Leu Pro Val Gln Thr 
                485                 490                 495     


Ile Lys Glu Glu Glu Ile Gln Pro Gly Glu Glu Met Pro His Leu Ala 
            500                 505                 510         


Arg Pro Ile Lys Val Glu Ser Pro Pro Leu Glu Glu Trp Pro Ser Pro 
        515                 520                 525             


Ala Pro Ser Phe Lys Glu Glu Ser Ser His Ser Trp Glu Asp Ser Ser 
    530                 535                 540                 


Gln Ser Pro Thr Pro Arg Pro Lys Lys Ser Tyr Ser Gly Leu Arg Ser 
545                 550                 555                 560 


Pro Thr Arg Cys Val Ser Glu Met Leu Val Ile Gln His Arg Glu Arg 
                565                 570                 575     


Arg Glu Arg Ser Arg Ser Arg Arg Lys Gln His Leu Leu Pro Pro Cys 
            580                 585                 590         


Val Asp Glu Pro Glu Leu Leu Phe Ser Glu Gly Pro Ser Thr Ser Arg 
        595                 600                 605             


Trp Ala Ala Glu Leu Pro Phe Pro Ala Asp Ser Ser Asp Pro Ala Ser 
    610                 615                 620                 


Gln Leu Ser Tyr Ser Gln Glu Val Gly Gly Pro Phe Lys Thr Pro Ile 
625                 630                 635                 640 


Lys Glu Thr Leu Pro Ile Ser Ser Thr Pro Ser Lys Ser Val Leu Pro 
                645                 650                 655     


Arg Thr Pro Glu Ser Trp Arg Leu Thr Pro Pro Ala Lys Val Gly Gly 
            660                 665                 670         


Leu Asp Phe Ser Pro Val Gln Thr Ser Gln Gly Ala Ser Asp Pro Leu 
        675                 680                 685             


Pro Asp Pro Leu Gly Leu Met Asp Leu Ser Thr Thr Pro Leu Gln Ser 
    690                 695                 700                 


Ala Pro Pro Leu Glu Ser Pro Gln Arg Leu Leu Ser Ser Glu Pro Leu 
705                 710                 715                 720 


Asp Leu Ile Ser Val Pro Phe Gly Asn Ser Ser Pro Ser Asp Ile Asp 
                725                 730                 735     


Val Pro Lys Pro Gly Ser Pro Glu Pro Gln Val Ser Gly Leu Ala Ala 
            740                 745                 750         


Asn Arg Ser Leu Thr Glu Gly Leu Val Leu Asp Thr Met Asn Asp Ser 
        755                 760                 765             


Leu Ser Lys Ile Leu Leu Asp Ile Ser Phe Pro Gly Leu Asp Glu Asp 
    770                 775                 780                 


Pro Leu Gly Pro Asp Asn Ile Asn Trp Ser Gln Phe Ile Pro Glu Leu 
785                 790                 795                 800 


Gln 
    


<210>  774
<211>  748
<212>  PRT
<213>  Homo sapiens

<400>  774

Met Lys Thr Ser Pro Arg Arg Pro Leu Ile Leu Lys Arg Arg Arg Leu 
1               5                   10                  15      


Pro Leu Pro Val Gln Asn Ala Pro Ser Glu Thr Ser Glu Glu Glu Pro 
            20                  25                  30          


Lys Arg Ser Pro Ala Gln Gln Glu Ser Asn Gln Ala Glu Ala Ser Lys 
        35                  40                  45              


Glu Val Ala Glu Ser Asn Ser Cys Lys Phe Pro Ala Gly Ile Lys Ile 
    50                  55                  60                  


Ile Asn His Pro Thr Met Pro Asn Thr Gln Val Val Ala Ile Pro Asn 
65                  70                  75                  80  


Asn Ala Asn Ile His Ser Ile Ile Thr Ala Leu Thr Ala Lys Gly Lys 
                85                  90                  95      


Glu Ser Gly Ser Ser Gly Pro Asn Lys Phe Ile Leu Ile Ser Cys Gly 
            100                 105                 110         


Gly Ala Pro Thr Gln Pro Pro Gly Leu Arg Pro Gln Thr Gln Thr Ser 
        115                 120                 125             


Tyr Asp Ala Lys Arg Thr Glu Val Thr Leu Glu Thr Leu Gly Pro Lys 
    130                 135                 140                 


Pro Ala Ala Arg Asp Val Asn Leu Pro Arg Pro Pro Gly Ala Leu Cys 
145                 150                 155                 160 


Glu Gln Lys Arg Glu Thr Cys Ala Asp Gly Glu Ala Ala Gly Cys Thr 
                165                 170                 175     


Ile Asn Asn Ser Leu Ser Asn Ile Gln Trp Leu Arg Lys Met Ser Ser 
            180                 185                 190         


Asp Gly Leu Gly Ser Arg Ser Ile Lys Gln Glu Met Glu Glu Lys Glu 
        195                 200                 205             


Asn Cys His Leu Glu Gln Arg Gln Val Lys Val Glu Glu Pro Ser Arg 
    210                 215                 220                 


Pro Ser Ala Ser Trp Gln Asn Ser Val Ser Glu Arg Pro Pro Tyr Ser 
225                 230                 235                 240 


Tyr Met Ala Met Ile Gln Phe Ala Ile Asn Ser Thr Glu Arg Lys Arg 
                245                 250                 255     


Met Thr Leu Lys Asp Ile Tyr Thr Trp Ile Glu Asp His Phe Pro Tyr 
            260                 265                 270         


Phe Lys His Ile Ala Lys Pro Gly Trp Lys Asn Ser Ile Arg His Asn 
        275                 280                 285             


Leu Ser Leu His Asp Met Phe Val Arg Glu Thr Ser Ala Asn Gly Lys 
    290                 295                 300                 


Val Ser Phe Trp Thr Ile His Pro Ser Ala Asn Arg Tyr Leu Thr Leu 
305                 310                 315                 320 


Asp Gln Val Phe Lys Gln Gln Lys Arg Pro Asn Pro Glu Leu Arg Arg 
                325                 330                 335     


Asn Met Thr Ile Lys Thr Glu Leu Pro Leu Gly Ala Arg Arg Lys Met 
            340                 345                 350         


Lys Pro Leu Leu Pro Arg Val Ser Ser Tyr Leu Val Pro Ile Gln Phe 
        355                 360                 365             


Pro Val Asn Gln Ser Leu Val Leu Gln Pro Ser Val Lys Val Pro Leu 
    370                 375                 380                 


Pro Leu Ala Ala Ser Leu Met Ser Ser Glu Leu Ala Arg His Ser Lys 
385                 390                 395                 400 


Arg Val Arg Ile Ala Pro Lys Val Leu Leu Ala Glu Glu Gly Ile Ala 
                405                 410                 415     


Pro Leu Ser Ser Ala Gly Pro Gly Lys Glu Glu Lys Leu Leu Phe Gly 
            420                 425                 430         


Glu Gly Phe Ser Pro Leu Leu Pro Val Gln Thr Ile Lys Glu Glu Glu 
        435                 440                 445             


Ile Gln Pro Gly Glu Glu Met Pro His Leu Ala Arg Pro Ile Lys Val 
    450                 455                 460                 


Glu Ser Pro Pro Leu Glu Glu Trp Pro Ser Pro Ala Pro Ser Phe Lys 
465                 470                 475                 480 


Glu Glu Ser Ser His Ser Trp Glu Asp Ser Ser Gln Ser Pro Thr Pro 
                485                 490                 495     


Arg Pro Lys Lys Ser Tyr Ser Gly Leu Arg Ser Pro Thr Arg Cys Val 
            500                 505                 510         


Ser Glu Met Leu Val Ile Gln His Arg Glu Arg Arg Glu Arg Ser Arg 
        515                 520                 525             


Ser Arg Arg Lys Gln His Leu Leu Pro Pro Cys Val Asp Glu Pro Glu 
    530                 535                 540                 


Leu Leu Phe Ser Glu Gly Pro Ser Thr Ser Arg Trp Ala Ala Glu Leu 
545                 550                 555                 560 


Pro Phe Pro Ala Asp Ser Ser Asp Pro Ala Ser Gln Leu Ser Tyr Ser 
                565                 570                 575     


Gln Glu Val Gly Gly Pro Phe Lys Thr Pro Ile Lys Glu Thr Leu Pro 
            580                 585                 590         


Ile Ser Ser Thr Pro Ser Lys Ser Val Leu Pro Arg Thr Pro Glu Ser 
        595                 600                 605             


Trp Arg Leu Thr Pro Pro Ala Lys Val Gly Gly Leu Asp Phe Ser Pro 
    610                 615                 620                 


Val Gln Thr Ser Gln Gly Ala Ser Asp Pro Leu Pro Asp Pro Leu Gly 
625                 630                 635                 640 


Leu Met Asp Leu Ser Thr Thr Pro Leu Gln Ser Ala Pro Pro Leu Glu 
                645                 650                 655     


Ser Pro Gln Arg Leu Leu Ser Ser Glu Pro Leu Asp Leu Ile Ser Val 
            660                 665                 670         


Pro Phe Gly Asn Ser Ser Pro Ser Asp Ile Asp Val Pro Lys Pro Gly 
        675                 680                 685             


Ser Pro Glu Pro Gln Val Ser Gly Leu Ala Ala Asn Arg Ser Leu Thr 
    690                 695                 700                 


Glu Gly Leu Val Leu Asp Thr Met Asn Asp Ser Leu Ser Lys Ile Leu 
705                 710                 715                 720 


Leu Asp Ile Ser Phe Pro Gly Leu Asp Glu Asp Pro Leu Gly Pro Asp 
                725                 730                 735     


Asn Ile Asn Trp Ser Gln Phe Ile Pro Glu Leu Gln 
            740                 745             


<210>  775
<211>  763
<212>  PRT
<213>  Homo sapiens

<400>  775

Met Lys Thr Ser Pro Arg Arg Pro Leu Ile Leu Lys Arg Arg Arg Leu 
1               5                   10                  15      


Pro Leu Pro Val Gln Asn Ala Pro Ser Glu Thr Ser Glu Glu Glu Pro 
            20                  25                  30          


Lys Arg Ser Pro Ala Gln Gln Glu Ser Asn Gln Ala Glu Ala Ser Lys 
        35                  40                  45              


Glu Val Ala Glu Ser Asn Ser Cys Lys Phe Pro Ala Gly Ile Lys Ile 
    50                  55                  60                  


Ile Asn His Pro Thr Met Pro Asn Thr Gln Val Val Ala Ile Pro Asn 
65                  70                  75                  80  


Asn Ala Asn Ile His Ser Ile Ile Thr Ala Leu Thr Ala Lys Gly Lys 
                85                  90                  95      


Glu Ser Gly Ser Ser Gly Pro Asn Lys Phe Ile Leu Ile Ser Cys Gly 
            100                 105                 110         


Gly Ala Pro Thr Gln Pro Pro Gly Leu Arg Pro Gln Thr Gln Thr Ser 
        115                 120                 125             


Tyr Asp Ala Lys Arg Thr Glu Val Thr Leu Glu Thr Leu Gly Pro Lys 
    130                 135                 140                 


Pro Ala Ala Arg Asp Val Asn Leu Pro Arg Pro Pro Gly Ala Leu Cys 
145                 150                 155                 160 


Glu Gln Lys Arg Glu Thr Cys Ala Asp Gly Glu Ala Ala Gly Cys Thr 
                165                 170                 175     


Ile Asn Asn Ser Leu Ser Asn Ile Gln Trp Leu Arg Lys Met Ser Ser 
            180                 185                 190         


Asp Gly Leu Gly Ser Arg Ser Ile Lys Gln Glu Met Glu Glu Lys Glu 
        195                 200                 205             


Asn Cys His Leu Glu Gln Arg Gln Val Lys Val Glu Glu Pro Ser Arg 
    210                 215                 220                 


Pro Ser Ala Ser Trp Gln Asn Ser Val Ser Glu Arg Pro Pro Tyr Ser 
225                 230                 235                 240 


Tyr Met Ala Met Ile Gln Phe Ala Ile Asn Ser Thr Glu Arg Lys Arg 
                245                 250                 255     


Met Thr Leu Lys Asp Ile Tyr Thr Trp Ile Glu Asp His Phe Pro Tyr 
            260                 265                 270         


Phe Lys His Ile Ala Lys Pro Gly Trp Lys Asn Ser Ile Arg His Asn 
        275                 280                 285             


Leu Ser Leu His Asp Met Phe Val Arg Glu Thr Ser Ala Asn Gly Lys 
    290                 295                 300                 


Val Ser Phe Trp Thr Ile His Pro Ser Ala Asn Arg Tyr Leu Thr Leu 
305                 310                 315                 320 


Asp Gln Val Phe Lys Pro Leu Asp Pro Gly Ser Pro Gln Leu Pro Glu 
                325                 330                 335     


His Leu Glu Ser Gln Gln Lys Arg Pro Asn Pro Glu Leu Arg Arg Asn 
            340                 345                 350         


Met Thr Ile Lys Thr Glu Leu Pro Leu Gly Ala Arg Arg Lys Met Lys 
        355                 360                 365             


Pro Leu Leu Pro Arg Val Ser Ser Tyr Leu Val Pro Ile Gln Phe Pro 
    370                 375                 380                 


Val Asn Gln Ser Leu Val Leu Gln Pro Ser Val Lys Val Pro Leu Pro 
385                 390                 395                 400 


Leu Ala Ala Ser Leu Met Ser Ser Glu Leu Ala Arg His Ser Lys Arg 
                405                 410                 415     


Val Arg Ile Ala Pro Lys Val Leu Leu Ala Glu Glu Gly Ile Ala Pro 
            420                 425                 430         


Leu Ser Ser Ala Gly Pro Gly Lys Glu Glu Lys Leu Leu Phe Gly Glu 
        435                 440                 445             


Gly Phe Ser Pro Leu Leu Pro Val Gln Thr Ile Lys Glu Glu Glu Ile 
    450                 455                 460                 


Gln Pro Gly Glu Glu Met Pro His Leu Ala Arg Pro Ile Lys Val Glu 
465                 470                 475                 480 


Ser Pro Pro Leu Glu Glu Trp Pro Ser Pro Ala Pro Ser Phe Lys Glu 
                485                 490                 495     


Glu Ser Ser His Ser Trp Glu Asp Ser Ser Gln Ser Pro Thr Pro Arg 
            500                 505                 510         


Pro Lys Lys Ser Tyr Ser Gly Leu Arg Ser Pro Thr Arg Cys Val Ser 
        515                 520                 525             


Glu Met Leu Val Ile Gln His Arg Glu Arg Arg Glu Arg Ser Arg Ser 
    530                 535                 540                 


Arg Arg Lys Gln His Leu Leu Pro Pro Cys Val Asp Glu Pro Glu Leu 
545                 550                 555                 560 


Leu Phe Ser Glu Gly Pro Ser Thr Ser Arg Trp Ala Ala Glu Leu Pro 
                565                 570                 575     


Phe Pro Ala Asp Ser Ser Asp Pro Ala Ser Gln Leu Ser Tyr Ser Gln 
            580                 585                 590         


Glu Val Gly Gly Pro Phe Lys Thr Pro Ile Lys Glu Thr Leu Pro Ile 
        595                 600                 605             


Ser Ser Thr Pro Ser Lys Ser Val Leu Pro Arg Thr Pro Glu Ser Trp 
    610                 615                 620                 


Arg Leu Thr Pro Pro Ala Lys Val Gly Gly Leu Asp Phe Ser Pro Val 
625                 630                 635                 640 


Gln Thr Ser Gln Gly Ala Ser Asp Pro Leu Pro Asp Pro Leu Gly Leu 
                645                 650                 655     


Met Asp Leu Ser Thr Thr Pro Leu Gln Ser Ala Pro Pro Leu Glu Ser 
            660                 665                 670         


Pro Gln Arg Leu Leu Ser Ser Glu Pro Leu Asp Leu Ile Ser Val Pro 
        675                 680                 685             


Phe Gly Asn Ser Ser Pro Ser Asp Ile Asp Val Pro Lys Pro Gly Ser 
    690                 695                 700                 


Pro Glu Pro Gln Val Ser Gly Leu Ala Ala Asn Arg Ser Leu Thr Glu 
705                 710                 715                 720 


Gly Leu Val Leu Asp Thr Met Asn Asp Ser Leu Ser Lys Ile Leu Leu 
                725                 730                 735     


Asp Ile Ser Phe Pro Gly Leu Asp Glu Asp Pro Leu Gly Pro Asp Asn 
            740                 745                 750         


Ile Asn Trp Ser Gln Phe Ile Pro Glu Leu Gln 
        755                 760             


<210>  776
<211>  206
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  776

Xaa Ala Lys Pro Gly Trp Lys Asn Ser Ile Arg His Asn Leu Ser Leu 
1               5                   10                  15      


His Asp Met Phe Val Arg Glu Thr Ser Ala Asn Gly Lys Val Ser Phe 
            20                  25                  30          


Trp Thr Ile His Pro Ser Ala Asn Arg Tyr Leu Thr Leu Asp Gln Val 
        35                  40                  45              


Phe Lys Pro Leu Asp Pro Gly Ser Pro Gln Leu Pro Glu His Leu Glu 
    50                  55                  60                  


Ser Gln Gln Gln Lys Arg Pro Asn Pro Glu Leu Arg Arg Asn Met Thr 
65                  70                  75                  80  


Ile Lys Thr Glu Leu Pro Leu Gly Ala Arg Arg Lys Met Lys Pro Leu 
                85                  90                  95      


Leu Pro Arg Val Ser Ser Tyr Leu Val Pro Ile Gln Phe Pro Val Asn 
            100                 105                 110         


Gln Ser Leu Val Leu Gln Pro Ser Val Lys Val Pro Leu Pro Leu Ala 
        115                 120                 125             


Ala Ser Leu Met Ser Ser Glu Leu Ala Arg His Ser Lys Arg Val Arg 
    130                 135                 140                 


Ile Ala Pro Lys Val Leu Leu Ala Glu Glu Gly Ile Ala Pro Leu Ser 
145                 150                 155                 160 


Ser Ala Gly Pro Gly Lys Glu Glu Lys Leu Leu Phe Gly Glu Gly Phe 
                165                 170                 175     


Ser Pro Leu Leu Pro Val Gln Thr Ile Lys Glu Glu Glu Ile Gln Pro 
            180                 185                 190         


Gly Glu Glu Met Pro His Leu Ala Arg Pro Ile Lys Val Glu 
        195                 200                 205     


<210>  777
<211>  80
<212>  PRT
<213>  Homo sapiens

<400>  777

Thr Ala Leu Thr Ala Lys Gly Lys Glu Ser Gly Ser Ser Gly Pro Asn 
1               5                   10                  15      


Lys Phe Ile Leu Ile Ser Cys Gly Gly Ala Pro Thr Gln Pro Pro Gly 
            20                  25                  30          


Leu Arg Pro Gln Thr Gln Thr Ser Tyr Asp Ala Lys Arg Thr Glu Val 
        35                  40                  45              


Thr Leu Glu Thr Leu Gly Pro Lys Pro Ala Ala Arg Asp Val Asn Leu 
    50                  55                  60                  


Pro Arg Pro Pro Gly Ala Leu Cys Glu Gln Lys Arg Glu Thr Cys Gly 
65                  70                  75                  80  


<210>  778
<211>  748
<212>  PRT
<213>  Homo sapiens

<400>  778

Met Lys Thr Ser Pro Arg Arg Pro Leu Ile Leu Lys Arg Arg Arg Leu 
1               5                   10                  15      


Pro Leu Pro Val Gln Asn Ala Pro Ser Glu Thr Ser Glu Glu Glu Pro 
            20                  25                  30          


Lys Arg Ser Pro Ala Gln Gln Glu Ser Asn Gln Ala Glu Ala Ser Lys 
        35                  40                  45              


Glu Val Ala Glu Ser Asn Ser Cys Lys Phe Pro Ala Gly Ile Lys Ile 
    50                  55                  60                  


Ile Asn His Pro Thr Met Pro Asn Thr Gln Val Val Ala Ile Pro Asn 
65                  70                  75                  80  


Asn Ala Asn Ile His Ser Ile Ile Thr Ala Leu Thr Ala Lys Gly Lys 
                85                  90                  95      


Glu Ser Gly Ser Ser Gly Pro Asn Lys Phe Ile Leu Ile Ser Cys Gly 
            100                 105                 110         


Gly Ala Pro Thr Gln Pro Pro Gly Leu Arg Pro Gln Thr Gln Thr Ser 
        115                 120                 125             


Tyr Asp Ala Lys Arg Thr Glu Val Thr Leu Glu Thr Leu Gly Pro Lys 
    130                 135                 140                 


Pro Ala Ala Arg Asp Val Asn Leu Pro Arg Pro Pro Gly Ala Leu Cys 
145                 150                 155                 160 


Glu Gln Lys Arg Glu Thr Cys Asp Gly Glu Ala Ala Gly Cys Thr Ile 
                165                 170                 175     


Asn Asn Ser Leu Ser Asn Ile Gln Trp Leu Arg Lys Met Ser Ser Asp 
            180                 185                 190         


Gly Leu Gly Ser Arg Ser Ile Lys Gln Glu Met Glu Glu Lys Glu Asn 
        195                 200                 205             


Cys His Leu Glu Gln Arg Gln Val Lys Val Glu Glu Pro Ser Arg Pro 
    210                 215                 220                 


Ser Ala Ser Trp Gln Asn Ser Val Ser Glu Arg Pro Pro Tyr Ser Tyr 
225                 230                 235                 240 


Met Ala Met Ile Gln Phe Ala Ile Asn Ser Thr Glu Arg Lys Arg Met 
                245                 250                 255     


Thr Leu Lys Asp Ile Tyr Thr Trp Ile Glu Asp His Phe Pro Tyr Phe 
            260                 265                 270         


Lys His Ile Ala Lys Pro Gly Trp Lys Asn Ser Ile Arg His Asn Leu 
        275                 280                 285             


Ser Leu His Asp Met Phe Val Arg Glu Thr Ser Ala Asn Gly Lys Val 
    290                 295                 300                 


Ser Phe Trp Thr Ile His Pro Ser Ala Asn Arg Tyr Leu Thr Leu Asp 
305                 310                 315                 320 


Gln Val Phe Lys Gln Gln Gln Lys Arg Pro Asn Pro Glu Leu Arg Arg 
                325                 330                 335     


Asn Met Thr Ile Lys Thr Glu Leu Pro Leu Gly Ala Arg Arg Lys Met 
            340                 345                 350         


Lys Pro Leu Leu Pro Arg Val Ser Ser Tyr Leu Val Pro Ile Gln Phe 
        355                 360                 365             


Pro Val Asn Gln Ser Leu Val Leu Gln Pro Ser Val Lys Val Pro Leu 
    370                 375                 380                 


Pro Leu Ala Ala Ser Leu Met Ser Ser Glu Leu Ala Arg His Ser Lys 
385                 390                 395                 400 


Arg Val Arg Ile Ala Pro Lys Val Leu Leu Ala Glu Glu Gly Ile Ala 
                405                 410                 415     


Pro Leu Ser Ser Ala Gly Pro Gly Lys Glu Glu Lys Leu Leu Phe Gly 
            420                 425                 430         


Glu Gly Phe Ser Pro Leu Leu Pro Val Gln Thr Ile Lys Glu Glu Glu 
        435                 440                 445             


Ile Gln Pro Gly Glu Glu Met Pro His Leu Ala Arg Pro Ile Lys Val 
    450                 455                 460                 


Glu Ser Pro Pro Leu Glu Glu Trp Pro Ser Pro Ala Pro Ser Phe Lys 
465                 470                 475                 480 


Glu Glu Ser Ser His Ser Trp Glu Asp Ser Ser Gln Ser Pro Thr Pro 
                485                 490                 495     


Arg Pro Lys Lys Ser Tyr Ser Gly Leu Arg Ser Pro Thr Arg Cys Val 
            500                 505                 510         


Ser Glu Met Leu Val Ile Gln His Arg Glu Arg Arg Glu Arg Ser Arg 
        515                 520                 525             


Ser Arg Arg Lys Gln His Leu Leu Pro Pro Cys Val Asp Glu Pro Glu 
    530                 535                 540                 


Leu Leu Phe Ser Glu Gly Pro Ser Thr Ser Arg Trp Ala Ala Glu Leu 
545                 550                 555                 560 


Pro Phe Pro Ala Asp Ser Ser Asp Pro Ala Ser Gln Leu Ser Tyr Ser 
                565                 570                 575     


Gln Glu Val Gly Gly Pro Phe Lys Thr Pro Ile Lys Glu Thr Leu Pro 
            580                 585                 590         


Ile Ser Ser Thr Pro Ser Lys Ser Val Leu Pro Arg Thr Pro Glu Ser 
        595                 600                 605             


Trp Arg Leu Thr Pro Pro Ala Lys Val Gly Gly Leu Asp Phe Ser Pro 
    610                 615                 620                 


Val Gln Thr Ser Gln Gly Ala Ser Asp Pro Leu Pro Asp Pro Leu Gly 
625                 630                 635                 640 


Leu Met Asp Leu Ser Thr Thr Pro Leu Gln Ser Ala Pro Pro Leu Glu 
                645                 650                 655     


Ser Pro Gln Arg Leu Leu Ser Ser Glu Pro Leu Asp Leu Ile Ser Val 
            660                 665                 670         


Pro Phe Gly Asn Ser Ser Pro Ser Asp Ile Asp Val Pro Lys Pro Gly 
        675                 680                 685             


Ser Pro Glu Pro Gln Val Ser Gly Leu Ala Ala Asn Arg Ser Leu Thr 
    690                 695                 700                 


Glu Gly Leu Val Leu Asp Thr Met Asn Asp Ser Leu Ser Lys Ile Leu 
705                 710                 715                 720 


Leu Asp Ile Ser Phe Pro Gly Leu Asp Glu Asp Pro Leu Gly Pro Asp 
                725                 730                 735     


Asn Ile Asn Trp Ser Gln Phe Ile Pro Glu Leu Gln 
            740                 745             


<210>  779
<211>  432
<212>  PRT
<213>  Homo sapiens

<400>  779

Met Ser Glu Leu Lys Asp Cys Pro Leu Gln Phe His Asp Phe Lys Ser 
1               5                   10                  15      


Val Asp His Leu Lys Val Cys Pro Arg Tyr Thr Ala Val Leu Ala Arg 
            20                  25                  30          


Ser Glu Asp Asp Gly Ile Gly Ile Glu Glu Leu Asp Thr Leu Gln Leu 
        35                  40                  45              


Glu Leu Glu Thr Leu Leu Ser Ser Ala Ser Arg Arg Leu Arg Val Leu 
    50                  55                  60                  


Glu Ala Glu Thr Gln Ile Leu Thr Asp Trp Gln Asp Lys Lys Gly Asp 
65                  70                  75                  80  


Arg Arg Phe Leu Lys Leu Gly Arg Asp His Glu Leu Gly Ala Pro Pro 
                85                  90                  95      


Lys His Gly Lys Pro Lys Lys Gln Lys Leu Glu Gly Lys Ala Gly His 
            100                 105                 110         


Gly Pro Gly Pro Gly Pro Gly Arg Pro Lys Ser Lys Asn Leu Gln Pro 
        115                 120                 125             


Lys Ile Gln Glu Tyr Glu Phe Thr Asp Asp Pro Ile Asp Val Pro Arg 
    130                 135                 140                 


Ile Pro Lys Asn Asp Ala Pro Asn Arg Phe Trp Ala Ser Val Glu Pro 
145                 150                 155                 160 


Tyr Cys Ala Asp Ile Thr Ser Glu Glu Val Arg Thr Leu Glu Glu Leu 
                165                 170                 175     


Leu Lys Pro Pro Glu Asp Glu Ala Glu His Tyr Lys Ile Pro Pro Leu 
            180                 185                 190         


Gly Lys His Tyr Ser Gln Arg Trp Ala Gln Glu Asp Leu Leu Glu Glu 
        195                 200                 205             


Gln Lys Asp Gly Ala Arg Ala Ala Ala Val Ala Asp Lys Lys Lys Gly 
    210                 215                 220                 


Leu Met Gly Pro Leu Thr Glu Leu Asp Thr Lys Asp Val Asp Ala Leu 
225                 230                 235                 240 


Leu Lys Lys Ser Glu Ala Gln His Glu Gln Pro Glu Asp Gly Cys Pro 
                245                 250                 255     


Phe Gly Ala Leu Thr Gln Arg Leu Leu Gln Ala Leu Val Glu Glu Asn 
            260                 265                 270         


Ile Ile Ser Pro Met Glu Asp Ser Pro Ile Pro Asp Met Ser Gly Lys 
        275                 280                 285             


Glu Ser Gly Ala Asp Gly Ala Ser Thr Ser Pro Arg Asn Gln Asn Lys 
    290                 295                 300                 


Pro Phe Ser Val Pro His Thr Lys Ser Leu Glu Ser Arg Ile Lys Glu 
305                 310                 315                 320 


Glu Leu Ile Ala Gln Gly Leu Leu Glu Ser Glu Asp Arg Pro Ala Glu 
                325                 330                 335     


Asp Ser Glu Asp Glu Val Leu Ala Glu Leu Arg Lys Arg Gln Ala Glu 
            340                 345                 350         


Leu Lys Ala Leu Ser Ala His Asn Arg Thr Lys Lys His Asp Leu Leu 
        355                 360                 365             


Arg Leu Ala Lys Glu Glu Val Ser Arg Gln Glu Leu Arg Gln Arg Val 
    370                 375                 380                 


Arg Met Ala Asp Asn Glu Val Met Asp Ala Phe Arg Lys Ile Met Ala 
385                 390                 395                 400 


Ala Arg Gln Lys Lys Arg Thr Pro Thr Lys Lys Glu Lys Asp Gln Ala 
                405                 410                 415     


Trp Lys Thr Leu Lys Glu Arg Glu Ser Ile Leu Lys Leu Leu Asp Gly 
            420                 425                 430         


<210>  780
<211>  432
<212>  PRT
<213>  Homo sapiens

<400>  780

Met Ser Glu Leu Lys Asp Cys Pro Leu Gln Phe His Asp Phe Lys Ser 
1               5                   10                  15      


Val Asp His Leu Lys Val Cys Pro Arg Tyr Thr Ala Val Leu Ala Arg 
            20                  25                  30          


Ser Glu Asp Asp Gly Ile Gly Ile Glu Glu Leu Asp Thr Leu Gln Leu 
        35                  40                  45              


Glu Leu Glu Thr Leu Leu Ser Ser Ala Ser Arg Arg Leu Arg Val Leu 
    50                  55                  60                  


Glu Ala Glu Thr Gln Ile Leu Thr Asp Trp Gln Asp Lys Lys Gly Asp 
65                  70                  75                  80  


Arg Arg Phe Leu Lys Leu Gly Arg Asp His Glu Leu Gly Ala Pro Pro 
                85                  90                  95      


Lys His Gly Lys Pro Lys Lys Gln Lys Leu Glu Gly Lys Ala Gly His 
            100                 105                 110         


Gly Pro Gly Pro Gly Pro Gly Arg Pro Lys Ser Lys Asn Leu Gln Pro 
        115                 120                 125             


Lys Ile Gln Glu Tyr Glu Phe Thr Asp Asp Pro Ile Asp Val Pro Arg 
    130                 135                 140                 


Ile Pro Lys Asn Asp Ala Pro Asn Arg Phe Trp Ala Ser Val Glu Pro 
145                 150                 155                 160 


Tyr Cys Ala Asp Ile Thr Ser Glu Glu Val Arg Thr Leu Glu Glu Leu 
                165                 170                 175     


Leu Lys Pro Pro Glu Asp Glu Ala Glu His Tyr Lys Ile Pro Pro Leu 
            180                 185                 190         


Gly Lys His Tyr Ser Gln Arg Trp Ala Gln Glu Asp Leu Leu Glu Glu 
        195                 200                 205             


Gln Lys Asp Gly Ala Arg Ala Ala Ala Val Ala Asp Lys Lys Lys Gly 
    210                 215                 220                 


Leu Met Gly Pro Leu Thr Glu Leu Asp Thr Lys Asp Val Asp Ala Leu 
225                 230                 235                 240 


Leu Lys Lys Ser Glu Ala Gln His Glu Gln Pro Glu Asp Gly Cys Pro 
                245                 250                 255     


Phe Gly Ala Leu Thr Gln Arg Leu Leu Gln Ala Leu Val Glu Glu Asn 
            260                 265                 270         


Ile Ile Ser Pro Met Glu Asp Ser Pro Ile Pro Asp Met Ser Gly Lys 
        275                 280                 285             


Glu Ser Gly Ala Asp Gly Ala Ser Thr Ser Pro Arg Asn Gln Asn Lys 
    290                 295                 300                 


Pro Phe Ser Val Pro His Thr Lys Ser Leu Glu Ser Arg Ile Lys Glu 
305                 310                 315                 320 


Glu Leu Ile Ala Gln Gly Leu Leu Glu Ser Glu Asp Arg Pro Ala Glu 
                325                 330                 335     


Asp Ser Glu Asp Glu Val Leu Ala Glu Leu Arg Lys Arg Gln Ala Glu 
            340                 345                 350         


Leu Lys Ala Leu Ser Ala His Asn Arg Thr Lys Lys His Asp Leu Leu 
        355                 360                 365             


Arg Leu Ala Lys Glu Glu Val Ser Arg Gln Glu Leu Arg Gln Arg Val 
    370                 375                 380                 


Arg Met Ala Asp Asn Glu Val Met Asp Ala Phe Arg Lys Ile Met Ala 
385                 390                 395                 400 


Ala Arg Gln Lys Lys Arg Thr Pro Thr Lys Lys Glu Lys Asp Gln Ala 
                405                 410                 415     


Trp Lys Thr Leu Lys Glu Arg Glu Ser Ile Leu Lys Leu Leu Asp Gly 
            420                 425                 430         


<210>  781
<211>  369
<212>  PRT
<213>  Homo sapiens

<400>  781

Met Ser Glu Leu Lys Asp Cys Pro Leu Gln Phe His Asp Phe Lys Ser 
1               5                   10                  15      


Val Asp His Leu Lys Val Cys Pro Arg Tyr Thr Ala Val Leu Ala Arg 
            20                  25                  30          


Ser Glu Asp Asp Gly Ile Gly Ile Glu Glu Leu Asp Thr Leu Gln Leu 
        35                  40                  45              


Glu Leu Glu Thr Leu Leu Ser Ser Ala Ser Arg Arg Leu Arg Val Leu 
    50                  55                  60                  


Glu Ala Glu Thr Gln Ile Leu Thr Asp Trp Gln Asp Lys Lys Gly Asp 
65                  70                  75                  80  


Arg Arg Phe Leu Lys Leu Gly Arg Asp His Glu Leu Gly Ala Pro Pro 
                85                  90                  95      


Lys His Gly Lys Pro Lys Lys Gln Lys Leu Glu Gly Lys Ala Gly His 
            100                 105                 110         


Gly Pro Gly Pro Gly Pro Gly Arg Pro Lys Ser Lys Asn Leu Gln Pro 
        115                 120                 125             


Lys Ile Gln Glu Tyr Glu Phe Thr Asp Asp Pro Ile Asp Val Pro Arg 
    130                 135                 140                 


Ile Pro Lys Asn Asp Ala Pro Asn Arg Phe Trp Ala Ser Val Glu Pro 
145                 150                 155                 160 


Tyr Cys Ala Asp Ile Thr Ser Glu Glu Val Arg Thr Leu Glu Glu Leu 
                165                 170                 175     


Leu Lys Pro Pro Glu Asp Glu Ala Glu His Tyr Lys Ile Pro Pro Leu 
            180                 185                 190         


Gly Lys His Tyr Ser Gln Arg Trp Ala Gln Glu Asp Leu Leu Glu Glu 
        195                 200                 205             


Gln Lys Asp Gly Ala Arg Ala Ala Ala Val Ala Asp Lys Lys Lys Gly 
    210                 215                 220                 


Leu Met Gly Pro Leu Thr Glu Leu Asp Thr Lys Asp Val Asp Ala Leu 
225                 230                 235                 240 


Leu Lys Lys Ser Glu Ala Gln His Glu Gln Pro Glu Asp Gly Cys Pro 
                245                 250                 255     


Phe Gly Ala Leu Thr Gln Arg Leu Leu Gln Ala Leu Val Glu Glu Asn 
            260                 265                 270         


Ile Ile Ser Pro Met Glu Asp Ser Pro Ile Pro Asp Met Ser Gly Lys 
        275                 280                 285             


Glu Ser Gly Ala Asp Gly Ala Ser Thr Ser Pro Arg Asn Gln Asn Lys 
    290                 295                 300                 


Pro Phe Ser Val Pro His Thr Lys Ser Leu Glu Ser Arg Ile Lys Glu 
305                 310                 315                 320 


Glu Leu Ile Ala Gln Gly Leu Leu Glu Ser Glu Asp Arg Pro Ala Glu 
                325                 330                 335     


Asp Ser Glu Asp Glu Val Leu Ala Glu Leu Arg Lys Arg Gln Ala Glu 
            340                 345                 350         


Leu Lys Ala Leu Ser Ala His Asn Arg Thr Lys Lys His Asp Leu Leu 
        355                 360                 365             


Arg 
    


<210>  782
<211>  95
<212>  PRT
<213>  Homo sapiens

<400>  782

Met Ser Glu Leu Lys Asp Cys Pro Leu Gln Phe His Asp Phe Lys Ser 
1               5                   10                  15      


Val Asp His Leu Lys Val Cys Pro Arg Tyr Thr Ala Val Leu Ala Arg 
            20                  25                  30          


Ser Glu Asp Asp Gly Ile Gly Ile Glu Glu Leu Asp Thr Leu Gln Leu 
        35                  40                  45              


Glu Leu Glu Thr Leu Leu Ser Ser Ala Ser Arg Arg Leu Arg Val Leu 
    50                  55                  60                  


Glu Ala Glu Thr Gln Ile Leu Thr Asp Trp Gln Asp Lys Lys Gly Asp 
65                  70                  75                  80  


Arg Arg Phe Leu Lys Leu Gly Arg Asp His Glu Leu Gly Ala Pro 
                85                  90                  95  


<210>  783
<211>  99
<212>  PRT
<213>  Homo sapiens

<400>  783

Met Pro Ser Asp Phe Ile Ser Leu Leu Ser Ala Asp Leu Asp Leu Glu 
1               5                   10                  15      


Ser Pro Lys Ser Leu Tyr Ser Arg Asp Ser Leu Lys Leu His Pro Ser 
            20                  25                  30          


Gln Asn Phe His Arg Ala Gly Leu Leu Glu Glu Ser Val Tyr Asp Leu 
        35                  40                  45              


Leu Pro Lys Glu Leu Gln Leu Pro Pro Ser Arg Glu Thr Ser Val Ala 
    50                  55                  60                  


Ser Met Ser Gln Thr Ser Gly Gly Glu Ala Gly Ser Pro Pro Pro Ala 
65                  70                  75                  80  


Val Val Ala Ala Gly Phe Ala Ser Glu Ala Gly Ser Val Cys Ile Lys 
                85                  90                  95      


Asn Asp Leu 
            


<210>  784
<211>  1531
<212>  PRT
<213>  Homo sapiens

<400>  784

Met Pro Ser Asp Phe Ile Ser Leu Leu Ser Ala Asp Leu Asp Leu Glu 
1               5                   10                  15      


Ser Pro Lys Ser Leu Tyr Ser Arg Glu Ser Val Tyr Asp Leu Leu Pro 
            20                  25                  30          


Lys Glu Leu Gln Leu Pro Pro Ser Arg Glu Thr Ser Val Ala Ser Met 
        35                  40                  45              


Ser Gln Thr Ser Gly Gly Glu Ala Gly Ser Pro Pro Pro Ala Val Val 
    50                  55                  60                  


Ala Ala Asp Ala Ser Ser Ala Pro Ser Ser Ser Ser Met Gly Gly Ala 
65                  70                  75                  80  


Cys Ser Ser Phe Thr Thr Ser Ser Ser Pro Thr Ile Tyr Ser Thr Ser 
                85                  90                  95      


Val Thr Asp Ser Lys Ala Met Gln Val Glu Ser Cys Ser Ser Ala Val 
            100                 105                 110         


Gly Val Ser Asn Arg Gly Val Ser Glu Lys Gln Leu Thr Ser Asn Thr 
        115                 120                 125             


Val Gln Gln His Pro Ser Thr Pro Lys Arg His Thr Val Leu Tyr Ile 
    130                 135                 140                 


Ser Pro Pro Pro Glu Asp Leu Leu Asp Asn Ser Arg Met Ser Cys Gln 
145                 150                 155                 160 


Asp Glu Gly Cys Gly Leu Glu Ser Glu Gln Ser Cys Ser Met Trp Met 
                165                 170                 175     


Glu Asp Ser Pro Ser Asn Phe Ser Asn Met Ser Thr Ser Ser Tyr Asn 
            180                 185                 190         


Asp Asn Thr Glu Val Pro Arg Lys Ser Arg Lys Arg Asn Pro Lys Gln 
        195                 200                 205             


Arg Pro Gly Val Lys Arg Arg Asp Cys Glu Glu Ser Asn Met Asp Ile 
    210                 215                 220                 


Phe Asp Ala Asp Ser Ala Lys Ala Pro His Tyr Val Leu Ser Gln Leu 
225                 230                 235                 240 


Thr Thr Asp Asn Lys Gly Asn Ser Lys Ala Gly Asn Gly Thr Leu Glu 
                245                 250                 255     


Asn Gln Lys Gly Thr Gly Val Lys Lys Ser Pro Met Leu Cys Gly Gln 
            260                 265                 270         


Tyr Pro Val Lys Ser Glu Gly Lys Glu Leu Lys Ile Val Val Gln Pro 
        275                 280                 285             


Glu Thr Gln His Arg Ala Arg Tyr Leu Thr Glu Gly Ser Arg Gly Ser 
    290                 295                 300                 


Val Lys Asp Arg Thr Gln Gln Gly Phe Pro Thr Val Lys Leu Glu Gly 
305                 310                 315                 320 


His Asn Glu Pro Val Val Leu Gln Val Phe Val Gly Asn Asp Ser Gly 
                325                 330                 335     


Arg Val Lys Pro His Gly Phe Tyr Gln Ala Cys Arg Val Thr Gly Arg 
            340                 345                 350         


Asn Thr Thr Pro Cys Lys Glu Val Asp Ile Glu Gly Thr Thr Val Ile 
        355                 360                 365             


Glu Val Gly Leu Asp Pro Ser Asn Asn Met Thr Leu Ala Val Asp Cys 
    370                 375                 380                 


Val Gly Ile Leu Lys Leu Arg Asn Ala Asp Val Glu Ala Arg Ile Gly 
385                 390                 395                 400 


Ile Ala Gly Ser Lys Lys Lys Ser Thr Arg Ala Arg Leu Val Phe Arg 
                405                 410                 415     


Val Asn Ile Met Arg Lys Asp Gly Ser Thr Leu Thr Leu Gln Thr Pro 
            420                 425                 430         


Ser Ser Pro Ile Leu Cys Thr Gln Pro Ala Gly Val Pro Glu Ile Leu 
        435                 440                 445             


Lys Lys Ser Leu His Ser Cys Ser Val Lys Gly Glu Glu Glu Val Phe 
    450                 455                 460                 


Leu Ile Gly Lys Asn Phe Leu Lys Gly Thr Lys Val Ile Phe Gln Glu 
465                 470                 475                 480 


Asn Val Ser Asp Glu Asn Ser Trp Lys Ser Glu Ala Glu Ile Asp Met 
                485                 490                 495     


Glu Leu Phe His Gln Asn His Leu Ile Val Lys Val Pro Pro Tyr His 
            500                 505                 510         


Asp Gln His Ile Thr Leu Pro Val Ser Val Gly Ile Tyr Val Val Thr 
        515                 520                 525             


Asn Ala Gly Arg Ser His Asp Val Gln Pro Phe Thr Tyr Thr Pro Asp 
    530                 535                 540                 


Pro Ala Ala Ala Gly Ala Leu Asn Val Asn Val Lys Lys Glu Ile Ser 
545                 550                 555                 560 


Ser Pro Ala Arg Pro Cys Ser Phe Glu Glu Ala Met Lys Ala Met Lys 
                565                 570                 575     


Thr Thr Gly Cys Asn Leu Asp Lys Val Asn Ile Ile Pro Asn Ala Leu 
            580                 585                 590         


Met Thr Pro Leu Ile Pro Ser Ser Met Ile Lys Ser Glu Asp Val Thr 
        595                 600                 605             


Pro Met Glu Val Thr Ala Glu Lys Arg Ser Ser Thr Ile Phe Lys Thr 
    610                 615                 620                 


Thr Lys Ser Val Gly Ser Thr Gln Gln Thr Leu Glu Asn Ile Ser Asn 
625                 630                 635                 640 


Ile Ala Gly Asn Gly Ser Phe Ser Ser Pro Ser Ser Ser His Leu Pro 
                645                 650                 655     


Ser Glu Asn Glu Lys Gln Gln Gln Ile Gln Pro Lys Ala Tyr Asn Pro 
            660                 665                 670         


Glu Thr Leu Thr Thr Ile Gln Thr Gln Asp Ile Ser Gln Pro Gly Thr 
        675                 680                 685             


Phe Pro Ala Val Ser Ala Ser Ser Gln Leu Pro Asn Ser Asp Ala Leu 
    690                 695                 700                 


Leu Gln Gln Ala Thr Gln Phe Gln Thr Arg Glu Thr Gln Ser Arg Glu 
705                 710                 715                 720 


Ile Leu Gln Ser Asp Gly Thr Val Val Asn Leu Ser Gln Leu Thr Glu 
                725                 730                 735     


Ala Ser Gln Gln Gln Gln Gln Ser Pro Leu Gln Glu Gln Ala Gln Thr 
            740                 745                 750         


Leu Gln Gln Gln Ile Ser Ser Asn Ile Phe Pro Ser Pro Asn Ser Val 
        755                 760                 765             


Ser Gln Leu Gln Asn Thr Ile Gln Gln Leu Gln Ala Gly Ser Phe Thr 
    770                 775                 780                 


Gly Ser Thr Ala Ser Gly Ser Ser Gly Ser Val Asp Leu Val Gln Gln 
785                 790                 795                 800 


Val Leu Glu Ala Gln Gln Gln Leu Ser Ser Val Leu Phe Ser Ala Pro 
                805                 810                 815     


Asp Gly Asn Glu Asn Val Gln Glu Gln Leu Ser Ala Asp Ile Phe Gln 
            820                 825                 830         


Gln Val Ser Gln Ile Gln Ser Gly Val Ser Pro Gly Met Phe Ser Ser 
        835                 840                 845             


Thr Glu Pro Thr Val His Thr Arg Pro Asp Asn Leu Leu Pro Gly Arg 
    850                 855                 860                 


Ala Glu Ser Val His Pro Gln Ser Glu Asn Thr Leu Ser Asn Gln Gln 
865                 870                 875                 880 


Gln Gln Gln Gln Gln Gln Gln Gln Val Met Glu Ser Ser Ala Ala Met 
                885                 890                 895     


Val Met Glu Met Gln Gln Ser Ile Cys Gln Ala Ala Ala Gln Ile Gln 
            900                 905                 910         


Ser Glu Leu Phe Pro Ser Thr Ala Ser Ala Asn Gly Asn Leu Gln Gln 
        915                 920                 925             


Ser Pro Val Tyr Gln Gln Thr Ser His Met Met Ser Ala Leu Ser Thr 
    930                 935                 940                 


Asn Glu Asp Met Gln Met Gln Cys Glu Leu Phe Ser Ser Pro Pro Ala 
945                 950                 955                 960 


Val Ser Gly Asn Glu Thr Ser Thr Thr Thr Thr Gln Gln Val Ala Thr 
                965                 970                 975     


Pro Gly Thr Thr Met Phe Gln Thr Ser Ser Ser Gly Asp Gly Glu Glu 
            980                 985                 990         


Thr Gly Thr Gln Ala Lys Gln Ile  Gln Asn Ser Val Phe  Gln Thr Met 
        995                 1000                 1005             


Val Gln  Met Gln His Ser Gly  Asp Asn Gln Pro Gln  Val Asn Leu 
    1010                 1015                 1020             


Phe Ser  Ser Thr Lys Ser Met  Met Ser Val Gln Asn  Ser Gly Thr 
    1025                 1030                 1035             


Gln Gln  Gln Gly Asn Gly Leu  Phe Gln Gln Gly Asn  Glu Met Met 
    1040                 1045                 1050             


Ser Leu  Gln Ser Gly Asn Phe  Leu Gln Gln Ser Ser  His Ser Gln 
    1055                 1060                 1065             


Ala Gln  Leu Phe His Pro Gln  Asn Pro Ile Ala Asp  Ala Gln Asn 
    1070                 1075                 1080             


Leu Ser  Gln Glu Thr Gln Gly  Ser Leu Phe His Ser  Pro Asn Pro 
    1085                 1090                 1095             


Ile Val  His Ser Gln Thr Ser  Thr Thr Ser Ser Glu  Gln Met Gln 
    1100                 1105                 1110             


Pro Pro  Met Phe His Ser Gln  Ser Thr Ile Ala Val  Leu Gln Gly 
    1115                 1120                 1125             


Ser Ser  Val Pro Gln Asp Gln  Gln Ser Thr Asn Ile  Phe Leu Ser 
    1130                 1135                 1140             


Gln Ser  Pro Met Asn Asn Leu  Gln Thr Asn Thr Val  Ala Gln Glu 
    1145                 1150                 1155             


Ala Phe  Phe Ala Ala Pro Asn  Ser Ile Ser Pro Leu  Gln Ser Thr 
    1160                 1165                 1170             


Ser Asn  Ser Glu Gln Gln Ala  Ala Phe Gln Gln Gln  Ala Pro Ile 
    1175                 1180                 1185             


Ser His  Ile Gln Thr Pro Met  Leu Ser Gln Glu Gln  Ala Gln Pro 
    1190                 1195                 1200             


Pro Gln  Gln Gly Leu Phe Gln  Pro Gln Val Ala Leu  Gly Ser Leu 
    1205                 1210                 1215             


Pro Pro  Asn Pro Met Pro Gln  Ser Gln Gln Gly Thr  Met Phe Gln 
    1220                 1225                 1230             


Ser Gln  His Ser Ile Val Ala  Met Gln Ser Asn Ser  Pro Ser Gln 
    1235                 1240                 1245             


Glu Gln  Gln Gln Gln Gln Gln  Gln Gln Gln Gln Gln  Gln Gln Gln 
    1250                 1255                 1260             


Gln Gln  Gln Ser Ile Leu Phe  Ser Asn Gln Asn Thr  Met Ala Thr 
    1265                 1270                 1275             


Met Ala  Ser Pro Lys Gln Pro  Pro Pro Asn Met Ile  Phe Asn Pro 
    1280                 1285                 1290             


Asn Gln  Asn Pro Met Ala Asn  Gln Glu Gln Gln Asn  Gln Ser Ile 
    1295                 1300                 1305             


Phe His  Gln Gln Ser Asn Met  Ala Pro Met Asn Gln  Glu Gln Gln 
    1310                 1315                 1320             


Pro Met  Gln Phe Gln Ser Gln  Ser Thr Val Ser Ser  Leu Gln Asn 
    1325                 1330                 1335             


Pro Gly  Pro Thr Gln Ser Glu  Ser Ser Gln Thr Pro  Leu Phe His 
    1340                 1345                 1350             


Ser Ser  Pro Gln Ile Gln Leu  Val Gln Gly Ser Pro  Ser Ser Gln 
    1355                 1360                 1365             


Glu Gln  Gln Val Thr Leu Phe  Leu Ser Pro Ala Ser  Met Ser Ala 
    1370                 1375                 1380             


Leu Gln  Thr Ser Ile Asn Gln  Gln Asp Met Gln Gln  Ser Pro Leu 
    1385                 1390                 1395             


Tyr Ser  Pro Gln Asn Asn Met  Pro Gly Ile Gln Gly  Ala Thr Ser 
    1400                 1405                 1410             


Ser Pro  Gln Pro Gln Ala Thr  Leu Phe His Asn Thr  Ala Gly Gly 
    1415                 1420                 1425             


Thr Met  Asn Gln Leu Gln Asn  Ser Pro Gly Ser Ser  Gln Gln Thr 
    1430                 1435                 1440             


Ser Gly  Met Phe Leu Phe Gly  Ile Gln Asn Asn Cys  Ser Gln Leu 
    1445                 1450                 1455             


Leu Thr  Ser Gly Pro Ala Thr  Leu Pro Asp Gln Leu  Met Ala Ile 
    1460                 1465                 1470             


Ser Gln  Pro Gly Gln Pro Gln  Asn Glu Gly Gln Pro  Pro Val Thr 
    1475                 1480                 1485             


Thr Leu  Leu Ser Gln Gln Met  Pro Glu Asn Ser Pro  Leu Ala Ser 
    1490                 1495                 1500             


Ser Ile  Asn Thr Asn Gln Asn  Ile Glu Lys Ile Asp  Leu Leu Val 
    1505                 1510                 1515             


Ser Leu  Gln Asn Gln Gly Asn  Asn Leu Thr Gly Ser  Phe 
    1520                 1525                 1530     


<210>  785
<211>  119
<212>  PRT
<213>  Homo sapiens

<400>  785

Met Pro Ser Asp Phe Ile Ser Leu Leu Ser Ala Asp Leu Asp Leu Glu 
1               5                   10                  15      


Ser Pro Lys Ser Leu Tyr Ser Arg Asp Ser Leu Lys Leu His Pro Ser 
            20                  25                  30          


Gln Asn Phe His Arg Ala Gly Leu Leu Glu Glu Ser Val Tyr Asp Leu 
        35                  40                  45              


Leu Pro Lys Glu Leu Gln Leu Pro Pro Ser Arg Glu Thr Ser Val Ala 
    50                  55                  60                  


Ser Met Ser Gln Thr Ser Gly Gly Glu Ala Gly Ser Pro Pro Pro Ala 
65                  70                  75                  80  


Val Val Ala Ala Gly Ile Pro Glu Met Phe Ile Leu Cys Ile Leu Met 
                85                  90                  95      


Cys Met Ile Leu Arg Phe Lys Lys Gly Phe Ala Ser Glu Ala Gly Ser 
            100                 105                 110         


Val Cys Ile Lys Asn Asp Leu 
        115                 


<210>  786
<211>  1548
<212>  PRT
<213>  Homo sapiens

<400>  786

Met Pro Ser Asp Phe Ile Ser Leu Leu Ser Ala Asp Leu Asp Leu Glu 
1               5                   10                  15      


Ser Pro Lys Ser Leu Tyr Ser Arg Asp Ser Leu Lys Leu His Pro Ser 
            20                  25                  30          


Gln Asn Phe His Arg Ala Gly Leu Leu Glu Glu Ser Val Tyr Asp Leu 
        35                  40                  45              


Leu Pro Lys Glu Leu Gln Leu Pro Pro Ser Arg Glu Thr Ser Val Ala 
    50                  55                  60                  


Ser Met Ser Gln Thr Ser Gly Gly Glu Ala Gly Ser Pro Pro Pro Ala 
65                  70                  75                  80  


Val Val Ala Ala Asp Ala Ser Ser Ala Pro Ser Ser Ser Ser Met Gly 
                85                  90                  95      


Gly Ala Cys Ser Ser Phe Thr Thr Ser Ser Ser Pro Thr Ile Tyr Ser 
            100                 105                 110         


Thr Ser Val Thr Asp Ser Lys Ala Met Gln Val Glu Ser Cys Ser Ser 
        115                 120                 125             


Ala Val Gly Val Ser Asn Arg Gly Val Ser Glu Lys Gln Leu Thr Ser 
    130                 135                 140                 


Asn Thr Val Gln Gln His Pro Ser Thr Pro Lys Arg His Thr Val Leu 
145                 150                 155                 160 


Tyr Ile Ser Pro Pro Pro Glu Asp Leu Leu Asp Asn Ser Arg Met Ser 
                165                 170                 175     


Cys Gln Asp Glu Gly Cys Gly Leu Glu Ser Glu Gln Ser Cys Ser Met 
            180                 185                 190         


Trp Met Glu Asp Ser Pro Ser Asn Phe Ser Asn Met Ser Thr Ser Ser 
        195                 200                 205             


Tyr Asn Asp Asn Thr Glu Val Pro Arg Lys Ser Arg Lys Arg Asn Pro 
    210                 215                 220                 


Lys Gln Arg Pro Gly Val Lys Arg Arg Asp Cys Glu Glu Ser Asn Met 
225                 230                 235                 240 


Asp Ile Phe Asp Ala Asp Ser Ala Lys Ala Pro His Tyr Val Leu Ser 
                245                 250                 255     


Gln Leu Thr Thr Asp Asn Lys Gly Asn Ser Lys Ala Gly Asn Gly Thr 
            260                 265                 270         


Leu Glu Asn Gln Lys Gly Thr Gly Val Lys Lys Ser Pro Met Leu Cys 
        275                 280                 285             


Gly Gln Tyr Pro Val Lys Ser Glu Gly Lys Glu Leu Lys Ile Val Val 
    290                 295                 300                 


Gln Pro Glu Thr Gln His Arg Ala Arg Tyr Leu Thr Glu Gly Ser Arg 
305                 310                 315                 320 


Gly Ser Val Lys Asp Arg Thr Gln Gln Gly Phe Pro Thr Val Lys Leu 
                325                 330                 335     


Glu Gly His Asn Glu Pro Val Val Leu Gln Val Phe Val Gly Asn Asp 
            340                 345                 350         


Ser Gly Arg Val Lys Pro His Gly Phe Tyr Gln Ala Cys Arg Val Thr 
        355                 360                 365             


Gly Arg Asn Thr Thr Pro Cys Lys Glu Val Asp Ile Glu Gly Thr Thr 
    370                 375                 380                 


Val Ile Glu Val Gly Leu Asp Pro Ser Asn Asn Met Thr Leu Ala Val 
385                 390                 395                 400 


Asp Cys Val Gly Ile Leu Lys Leu Arg Asn Ala Asp Val Glu Ala Arg 
                405                 410                 415     


Ile Gly Ile Ala Gly Ser Lys Lys Lys Ser Thr Arg Ala Arg Leu Val 
            420                 425                 430         


Phe Arg Val Asn Ile Met Arg Lys Asp Gly Ser Thr Leu Thr Leu Gln 
        435                 440                 445             


Thr Pro Ser Ser Pro Ile Leu Cys Thr Gln Pro Ala Gly Val Pro Glu 
    450                 455                 460                 


Ile Leu Lys Lys Ser Leu His Ser Cys Ser Val Lys Gly Glu Glu Glu 
465                 470                 475                 480 


Val Phe Leu Ile Gly Lys Asn Phe Leu Lys Gly Thr Lys Val Ile Phe 
                485                 490                 495     


Gln Glu Asn Val Ser Asp Glu Asn Ser Trp Lys Ser Glu Ala Glu Ile 
            500                 505                 510         


Asp Met Glu Leu Phe His Gln Asn His Leu Ile Val Lys Val Pro Pro 
        515                 520                 525             


Tyr His Asp Gln His Ile Thr Leu Pro Val Ser Val Gly Ile Tyr Val 
    530                 535                 540                 


Val Thr Asn Ala Gly Arg Ser His Asp Val Gln Pro Phe Thr Tyr Thr 
545                 550                 555                 560 


Pro Asp Pro Ala Ala Gly Ala Leu Asn Val Asn Val Lys Lys Glu Ile 
                565                 570                 575     


Ser Ser Pro Ala Arg Pro Cys Ser Phe Glu Glu Ala Met Lys Ala Met 
            580                 585                 590         


Lys Thr Thr Gly Cys Asn Leu Asp Lys Val Asn Ile Ile Pro Asn Ala 
        595                 600                 605             


Leu Met Thr Pro Leu Ile Pro Ser Ser Met Ile Lys Ser Glu Asp Val 
    610                 615                 620                 


Thr Pro Met Glu Val Thr Ala Glu Lys Arg Ser Ser Thr Ile Phe Lys 
625                 630                 635                 640 


Thr Thr Lys Ser Val Gly Ser Thr Gln Gln Thr Leu Glu Asn Ile Ser 
                645                 650                 655     


Asn Ile Ala Gly Asn Gly Ser Phe Ser Ser Pro Ser Ser Ser His Leu 
            660                 665                 670         


Pro Ser Glu Asn Glu Lys Gln Gln Gln Ile Gln Pro Lys Ala Tyr Asn 
        675                 680                 685             


Pro Glu Thr Leu Thr Thr Ile Gln Thr Gln Asp Ile Ser Gln Pro Gly 
    690                 695                 700                 


Thr Phe Pro Ala Val Ser Ala Ser Ser Gln Leu Pro Asn Ser Asp Ala 
705                 710                 715                 720 


Leu Leu Gln Gln Ala Thr Gln Phe Gln Thr Arg Glu Thr Gln Ser Arg 
                725                 730                 735     


Glu Ile Leu Gln Ser Asp Gly Thr Val Val Asn Leu Ser Gln Leu Thr 
            740                 745                 750         


Glu Ala Ser Gln Gln Gln Gln Gln Ser Pro Leu Gln Glu Gln Ala Gln 
        755                 760                 765             


Thr Leu Gln Gln Gln Ile Ser Ser Asn Ile Phe Pro Ser Pro Asn Ser 
    770                 775                 780                 


Val Ser Gln Leu Gln Asn Thr Ile Gln Gln Leu Gln Ala Gly Ser Phe 
785                 790                 795                 800 


Thr Gly Ser Thr Ala Ser Gly Ser Ser Gly Ser Val Asp Leu Val Gln 
                805                 810                 815     


Gln Val Leu Glu Ala Gln Gln Gln Leu Ser Ser Val Leu Phe Ser Ala 
            820                 825                 830         


Pro Asp Gly Asn Glu Asn Val Gln Glu Gln Leu Ser Ala Asp Ile Phe 
        835                 840                 845             


Gln Gln Val Ser Gln Ile Gln Ser Gly Val Ser Pro Gly Met Phe Ser 
    850                 855                 860                 


Ser Thr Glu Pro Thr Val His Thr Arg Pro Asp Asn Leu Leu Pro Gly 
865                 870                 875                 880 


Arg Ala Glu Ser Val His Pro Gln Ser Glu Asn Thr Leu Ser Asn Gln 
                885                 890                 895     


Gln Gln Gln Gln Gln Gln Gln Gln Gln Val Met Glu Ser Ser Ala Ala 
            900                 905                 910         


Met Val Met Glu Met Gln Gln Ser Ile Cys Gln Ala Ala Ala Gln Ile 
        915                 920                 925             


Gln Ser Glu Leu Phe Pro Ser Thr Ala Ser Ala Asn Gly Asn Leu Gln 
    930                 935                 940                 


Gln Ser Pro Val Tyr Gln Gln Thr Ser His Met Met Ser Ala Leu Ser 
945                 950                 955                 960 


Thr Asn Glu Asp Met Gln Met Gln Cys Glu Leu Phe Ser Ser Pro Pro 
                965                 970                 975     


Ala Val Ser Gly Asn Glu Thr Ser Thr Thr Thr Thr Gln Gln Val Ala 
            980                 985                 990         


Thr Pro Gly Thr Thr Met Phe Gln  Thr Ser Ser Ser Gly  Asp Gly Glu 
        995                 1000                 1005             


Glu Thr  Gly Thr Gln Ala Lys  Gln Ile Gln Asn Ser  Val Phe Gln 
    1010                 1015                 1020             


Thr Met  Val Gln Met Gln His  Ser Gly Asp Asn Gln  Pro Gln Val 
    1025                 1030                 1035             


Asn Leu  Phe Ser Ser Thr Lys  Ser Met Met Ser Val  Gln Asn Ser 
    1040                 1045                 1050             


Gly Thr  Gln Gln Gln Gly Asn  Gly Leu Phe Gln Gln  Gly Asn Glu 
    1055                 1060                 1065             


Met Met  Ser Leu Gln Ser Gly  Asn Phe Leu Gln Gln  Ser Ser His 
    1070                 1075                 1080             


Ser Gln  Ala Gln Leu Phe His  Pro Gln Asn Pro Ile  Ala Asp Ala 
    1085                 1090                 1095             


Gln Asn  Leu Ser Gln Glu Thr  Gln Gly Ser Leu Phe  His Ser Pro 
    1100                 1105                 1110             


Asn Pro  Ile Val His Ser Gln  Thr Ser Thr Thr Ser  Ser Glu Gln 
    1115                 1120                 1125             


Met Gln  Pro Pro Met Phe His  Ser Gln Ser Thr Ile  Ala Val Leu 
    1130                 1135                 1140             


Gln Gly  Ser Ser Val Pro Gln  Asp Gln Gln Ser Thr  Asn Ile Phe 
    1145                 1150                 1155             


Leu Ser  Gln Ser Pro Met Asn  Asn Leu Gln Thr Asn  Thr Val Ala 
    1160                 1165                 1170             


Gln Glu  Ala Phe Phe Ala Ala  Pro Asn Ser Ile Ser  Pro Leu Gln 
    1175                 1180                 1185             


Ser Thr  Ser Asn Ser Glu Gln  Gln Ala Ala Phe Gln  Gln Gln Ala 
    1190                 1195                 1200             


Pro Ile  Ser His Ile Gln Thr  Pro Met Leu Ser Gln  Glu Gln Ala 
    1205                 1210                 1215             


Gln Pro  Pro Gln Gln Gly Leu  Phe Gln Pro Gln Val  Ala Leu Gly 
    1220                 1225                 1230             


Ser Leu  Pro Pro Asn Pro Met  Pro Gln Ser Gln Gln  Gly Thr Met 
    1235                 1240                 1245             


Phe Gln  Ser Gln His Ser Ile  Val Ala Met Gln Ser  Asn Ser Pro 
    1250                 1255                 1260             


Ser Gln  Glu Gln Gln Gln Gln  Gln Gln Gln Gln Gln  Gln Gln Gln 
    1265                 1270                 1275             


Gln Gln  Gln Gln Gln Ser Ile  Leu Phe Ser Asn Gln  Asn Thr Met 
    1280                 1285                 1290             


Ala Thr  Met Ala Ser Pro Lys  Gln Pro Pro Pro Asn  Met Ile Phe 
    1295                 1300                 1305             


Asn Pro  Asn Gln Asn Pro Met  Ala Asn Gln Glu Gln  Gln Asn Gln 
    1310                 1315                 1320             


Ser Ile  Phe His Gln Gln Ser  Asn Met Ala Pro Met  Asn Gln Glu 
    1325                 1330                 1335             


Gln Gln  Pro Met Gln Phe Gln  Ser Gln Ser Thr Val  Ser Ser Leu 
    1340                 1345                 1350             


Gln Asn  Pro Gly Pro Thr Gln  Ser Glu Ser Ser Gln  Thr Pro Leu 
    1355                 1360                 1365             


Phe His  Ser Ser Pro Gln Ile  Gln Leu Val Gln Gly  Ser Pro Ser 
    1370                 1375                 1380             


Ser Gln  Glu Gln Gln Val Thr  Leu Phe Leu Ser Pro  Ala Ser Met 
    1385                 1390                 1395             


Ser Ala  Leu Gln Thr Ser Ile  Asn Gln Gln Asp Met  Gln Gln Ser 
    1400                 1405                 1410             


Pro Leu  Tyr Ser Pro Gln Asn  Asn Met Pro Gly Ile  Gln Gly Ala 
    1415                 1420                 1425             


Thr Ser  Ser Pro Gln Pro Gln  Ala Thr Leu Phe His  Asn Thr Ala 
    1430                 1435                 1440             


Gly Gly  Thr Met Asn Gln Leu  Gln Asn Ser Pro Gly  Ser Ser Gln 
    1445                 1450                 1455             


Gln Thr  Ser Gly Met Phe Leu  Phe Gly Ile Gln Asn  Asn Cys Ser 
    1460                 1465                 1470             


Gln Leu  Leu Thr Ser Gly Pro  Ala Thr Leu Pro Asp  Gln Leu Met 
    1475                 1480                 1485             


Ala Ile  Ser Gln Pro Gly Gln  Pro Gln Asn Glu Gly  Gln Pro Pro 
    1490                 1495                 1500             


Val Thr  Thr Leu Leu Ser Gln  Gln Met Pro Glu Asn  Ser Pro Leu 
    1505                 1510                 1515             


Ala Ser  Ser Ile Asn Thr Asn  Gln Asn Ile Glu Lys  Ile Asp Leu 
    1520                 1525                 1530             


Leu Val  Ser Leu Gln Asn Gln  Gly Asn Asn Leu Thr  Gly Ser Phe 
    1535                 1540                 1545             


<210>  787
<211>  1549
<212>  PRT
<213>  Homo sapiens

<400>  787

Met Pro Ser Asp Phe Ile Ser Leu Leu Ser Ala Asp Leu Asp Leu Glu 
1               5                   10                  15      


Ser Pro Lys Ser Leu Tyr Ser Arg Asp Ser Leu Lys Leu His Pro Ser 
            20                  25                  30          


Gln Asn Phe His Arg Ala Gly Leu Leu Glu Glu Ser Val Tyr Asp Leu 
        35                  40                  45              


Leu Pro Lys Glu Leu Gln Leu Pro Pro Ser Arg Glu Thr Ser Val Ala 
    50                  55                  60                  


Ser Met Ser Gln Thr Ser Gly Gly Glu Ala Gly Ser Pro Pro Pro Ala 
65                  70                  75                  80  


Val Val Ala Ala Asp Ala Ser Ser Ala Pro Ser Ser Ser Ser Met Gly 
                85                  90                  95      


Gly Ala Cys Ser Ser Phe Thr Thr Ser Ser Ser Pro Thr Ile Tyr Ser 
            100                 105                 110         


Thr Ser Val Thr Asp Ser Lys Ala Met Gln Val Glu Ser Cys Ser Ser 
        115                 120                 125             


Ala Val Gly Val Ser Asn Arg Gly Val Ser Glu Lys Gln Leu Thr Ser 
    130                 135                 140                 


Asn Thr Val Gln Gln His Pro Ser Thr Pro Lys Arg His Thr Val Leu 
145                 150                 155                 160 


Tyr Ile Ser Pro Pro Pro Glu Asp Leu Leu Asp Asn Ser Arg Met Ser 
                165                 170                 175     


Cys Gln Asp Glu Gly Cys Gly Leu Glu Ser Glu Gln Ser Cys Ser Met 
            180                 185                 190         


Trp Met Glu Asp Ser Pro Ser Asn Phe Ser Asn Met Ser Thr Ser Ser 
        195                 200                 205             


Tyr Asn Asp Asn Thr Glu Val Pro Arg Lys Ser Arg Lys Arg Asn Pro 
    210                 215                 220                 


Lys Gln Arg Pro Gly Val Lys Arg Arg Asp Cys Glu Glu Ser Asn Met 
225                 230                 235                 240 


Asp Ile Phe Asp Ala Asp Ser Ala Lys Ala Pro His Tyr Val Leu Ser 
                245                 250                 255     


Gln Leu Thr Thr Asp Asn Lys Gly Asn Ser Lys Ala Gly Asn Gly Thr 
            260                 265                 270         


Leu Glu Asn Gln Lys Gly Thr Gly Val Lys Lys Ser Pro Met Leu Cys 
        275                 280                 285             


Gly Gln Tyr Pro Val Lys Ser Glu Gly Lys Glu Leu Lys Ile Val Val 
    290                 295                 300                 


Gln Pro Glu Thr Gln His Arg Ala Arg Tyr Leu Thr Glu Gly Ser Arg 
305                 310                 315                 320 


Gly Ser Val Lys Asp Arg Thr Gln Gln Gly Phe Pro Thr Val Lys Leu 
                325                 330                 335     


Glu Gly His Asn Glu Pro Val Val Leu Gln Val Phe Val Gly Asn Asp 
            340                 345                 350         


Ser Gly Arg Val Lys Pro His Gly Phe Tyr Gln Ala Cys Arg Val Thr 
        355                 360                 365             


Gly Arg Asn Thr Thr Pro Cys Lys Glu Val Asp Ile Glu Gly Thr Thr 
    370                 375                 380                 


Val Ile Glu Val Gly Leu Asp Pro Ser Asn Asn Met Thr Leu Ala Val 
385                 390                 395                 400 


Asp Cys Val Gly Ile Leu Lys Leu Arg Asn Ala Asp Val Glu Ala Arg 
                405                 410                 415     


Ile Gly Ile Ala Gly Ser Lys Lys Lys Ser Thr Arg Ala Arg Leu Val 
            420                 425                 430         


Phe Arg Val Asn Ile Met Arg Lys Asp Gly Ser Thr Leu Thr Leu Gln 
        435                 440                 445             


Thr Pro Ser Ser Pro Ile Leu Cys Thr Gln Pro Ala Gly Val Pro Glu 
    450                 455                 460                 


Ile Leu Lys Lys Ser Leu His Ser Cys Ser Val Lys Gly Glu Glu Glu 
465                 470                 475                 480 


Val Phe Leu Ile Gly Lys Asn Phe Leu Lys Gly Thr Lys Val Ile Phe 
                485                 490                 495     


Gln Glu Asn Val Ser Asp Glu Asn Ser Trp Lys Ser Glu Ala Glu Ile 
            500                 505                 510         


Asp Met Glu Leu Phe His Gln Asn His Leu Ile Val Lys Val Pro Pro 
        515                 520                 525             


Tyr His Asp Gln His Ile Thr Leu Pro Val Ser Val Gly Ile Tyr Val 
    530                 535                 540                 


Val Thr Asn Ala Gly Arg Ser His Asp Val Gln Pro Phe Thr Tyr Thr 
545                 550                 555                 560 


Pro Asp Pro Ala Ala Ala Gly Ala Leu Asn Val Asn Val Lys Lys Glu 
                565                 570                 575     


Ile Ser Ser Pro Ala Arg Pro Cys Ser Phe Glu Glu Ala Met Lys Ala 
            580                 585                 590         


Met Lys Thr Thr Gly Cys Asn Leu Asp Lys Val Asn Ile Ile Pro Asn 
        595                 600                 605             


Ala Leu Met Thr Pro Leu Ile Pro Ser Ser Met Ile Lys Ser Glu Asp 
    610                 615                 620                 


Val Thr Pro Met Glu Val Thr Ala Glu Lys Arg Ser Ser Thr Ile Phe 
625                 630                 635                 640 


Lys Thr Thr Lys Ser Val Gly Ser Thr Gln Gln Thr Leu Glu Asn Ile 
                645                 650                 655     


Ser Asn Ile Ala Gly Asn Gly Ser Phe Ser Ser Pro Ser Ser Ser His 
            660                 665                 670         


Leu Pro Ser Glu Asn Glu Lys Gln Gln Gln Ile Gln Pro Lys Ala Tyr 
        675                 680                 685             


Asn Pro Glu Thr Leu Thr Thr Ile Gln Thr Gln Asp Ile Ser Gln Pro 
    690                 695                 700                 


Gly Thr Phe Pro Ala Val Ser Ala Ser Ser Gln Leu Pro Asn Ser Asp 
705                 710                 715                 720 


Ala Leu Leu Gln Gln Ala Thr Gln Phe Gln Thr Arg Glu Thr Gln Ser 
                725                 730                 735     


Arg Glu Ile Leu Gln Ser Asp Gly Thr Val Val Asn Leu Ser Gln Leu 
            740                 745                 750         


Thr Glu Ala Ser Gln Gln Gln Gln Gln Ser Pro Leu Gln Glu Gln Ala 
        755                 760                 765             


Gln Thr Leu Gln Gln Gln Ile Ser Ser Asn Ile Phe Pro Ser Pro Asn 
    770                 775                 780                 


Ser Val Ser Gln Leu Gln Asn Thr Ile Gln Gln Leu Gln Ala Gly Ser 
785                 790                 795                 800 


Phe Thr Gly Ser Thr Ala Ser Gly Ser Ser Gly Ser Val Asp Leu Val 
                805                 810                 815     


Gln Gln Val Leu Glu Ala Gln Gln Gln Leu Ser Ser Val Leu Phe Ser 
            820                 825                 830         


Ala Pro Asp Gly Asn Glu Asn Val Gln Glu Gln Leu Ser Ala Asp Ile 
        835                 840                 845             


Phe Gln Gln Val Ser Gln Ile Gln Ser Gly Val Ser Pro Gly Met Phe 
    850                 855                 860                 


Ser Ser Thr Glu Pro Thr Val His Thr Arg Pro Asp Asn Leu Leu Pro 
865                 870                 875                 880 


Gly Arg Ala Glu Ser Val His Pro Gln Ser Glu Asn Thr Leu Ser Asn 
                885                 890                 895     


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Val Met Glu Ser Ser Ala 
            900                 905                 910         


Ala Met Val Met Glu Met Gln Gln Ser Ile Cys Gln Ala Ala Ala Gln 
        915                 920                 925             


Ile Gln Ser Glu Leu Phe Pro Ser Thr Ala Ser Ala Asn Gly Asn Leu 
    930                 935                 940                 


Gln Gln Ser Pro Val Tyr Gln Gln Thr Ser His Met Met Ser Ala Leu 
945                 950                 955                 960 


Ser Thr Asn Glu Asp Met Gln Met Gln Cys Glu Leu Phe Ser Ser Pro 
                965                 970                 975     


Pro Ala Val Ser Gly Asn Glu Thr Ser Thr Thr Thr Thr Gln Gln Val 
            980                 985                 990         


Ala Thr Pro Gly Thr Thr Met Phe  Gln Thr Ser Ser Ser  Gly Asp Gly 
        995                 1000                 1005             


Glu Glu  Thr Gly Thr Gln Ala  Lys Gln Ile Gln Asn  Ser Val Phe 
    1010                 1015                 1020             


Gln Thr  Met Val Gln Met Gln  His Ser Gly Asp Asn  Gln Pro Gln 
    1025                 1030                 1035             


Val Asn  Leu Phe Ser Ser Thr  Lys Ser Met Met Ser  Val Gln Asn 
    1040                 1045                 1050             


Ser Gly  Thr Gln Gln Gln Gly  Asn Gly Leu Phe Gln  Gln Gly Asn 
    1055                 1060                 1065             


Glu Met  Met Ser Leu Gln Ser  Gly Asn Phe Leu Gln  Gln Ser Ser 
    1070                 1075                 1080             


His Ser  Gln Ala Gln Leu Phe  His Pro Gln Asn Pro  Ile Ala Asp 
    1085                 1090                 1095             


Ala Gln  Asn Leu Ser Gln Glu  Thr Gln Gly Ser Leu  Phe His Ser 
    1100                 1105                 1110             


Pro Asn  Pro Ile Val His Ser  Gln Thr Ser Thr Thr  Ser Ser Glu 
    1115                 1120                 1125             


Gln Met  Gln Pro Pro Met Phe  His Ser Gln Ser Thr  Ile Ala Val 
    1130                 1135                 1140             


Leu Gln  Gly Ser Ser Val Pro  Gln Asp Gln Gln Ser  Thr Asn Ile 
    1145                 1150                 1155             


Phe Leu  Ser Gln Ser Pro Met  Asn Asn Leu Gln Thr  Asn Thr Val 
    1160                 1165                 1170             


Ala Gln  Glu Ala Phe Phe Ala  Ala Pro Asn Ser Ile  Ser Pro Leu 
    1175                 1180                 1185             


Gln Ser  Thr Ser Asn Ser Glu  Gln Gln Ala Ala Phe  Gln Gln Gln 
    1190                 1195                 1200             


Ala Pro  Ile Ser His Ile Gln  Thr Pro Met Leu Ser  Gln Glu Gln 
    1205                 1210                 1215             


Ala Gln  Pro Pro Gln Gln Gly  Leu Phe Gln Pro Gln  Val Ala Leu 
    1220                 1225                 1230             


Gly Ser  Leu Pro Pro Asn Pro  Met Pro Gln Ser Gln  Gln Gly Thr 
    1235                 1240                 1245             


Met Phe  Gln Ser Gln His Ser  Ile Val Ala Met Gln  Ser Asn Ser 
    1250                 1255                 1260             


Pro Ser  Gln Glu Gln Gln Gln  Gln Gln Gln Gln Gln  Gln Gln Gln 
    1265                 1270                 1275             


Gln Gln  Gln Gln Gln Gln Ser  Ile Leu Phe Ser Asn  Gln Asn Thr 
    1280                 1285                 1290             


Met Ala  Thr Met Ala Ser Pro  Lys Gln Pro Pro Pro  Asn Met Ile 
    1295                 1300                 1305             


Phe Asn  Pro Asn Gln Asn Pro  Met Ala Asn Gln Glu  Gln Gln Asn 
    1310                 1315                 1320             


Gln Ser  Ile Phe His Gln Gln  Ser Asn Met Ala Pro  Met Asn Gln 
    1325                 1330                 1335             


Glu Gln  Gln Pro Met Gln Phe  Gln Ser Gln Ser Thr  Val Ser Ser 
    1340                 1345                 1350             


Leu Gln  Asn Pro Gly Pro Thr  Gln Ser Glu Ser Ser  Gln Thr Pro 
    1355                 1360                 1365             


Leu Phe  His Ser Ser Pro Gln  Ile Gln Leu Val Gln  Gly Ser Pro 
    1370                 1375                 1380             


Ser Ser  Gln Glu Gln Gln Val  Thr Leu Phe Leu Ser  Pro Ala Ser 
    1385                 1390                 1395             


Met Ser  Ala Leu Gln Thr Ser  Ile Asn Gln Gln Asp  Met Gln Gln 
    1400                 1405                 1410             


Ser Pro  Leu Tyr Ser Pro Gln  Asn Asn Met Pro Gly  Ile Gln Gly 
    1415                 1420                 1425             


Ala Thr  Ser Ser Pro Gln Pro  Gln Ala Thr Leu Phe  His Asn Thr 
    1430                 1435                 1440             


Ala Gly  Gly Thr Met Asn Gln  Leu Gln Asn Ser Pro  Gly Ser Ser 
    1445                 1450                 1455             


Gln Gln  Thr Ser Gly Met Phe  Leu Phe Gly Ile Gln  Asn Asn Cys 
    1460                 1465                 1470             


Ser Gln  Leu Leu Thr Ser Gly  Pro Ala Thr Leu Pro  Asp Gln Leu 
    1475                 1480                 1485             


Met Ala  Ile Ser Gln Pro Gly  Gln Pro Gln Asn Glu  Gly Gln Pro 
    1490                 1495                 1500             


Pro Val  Thr Thr Leu Leu Ser  Gln Gln Met Pro Glu  Asn Ser Pro 
    1505                 1510                 1515             


Leu Ala  Ser Ser Ile Asn Thr  Asn Gln Asn Ile Glu  Lys Ile Asp 
    1520                 1525                 1530             


Leu Leu  Val Ser Leu Gln Asn  Gln Gly Asn Asn Leu  Thr Gly Ser 
    1535                 1540                 1545             


Phe 
    


<210>  788
<211>  1455
<212>  PRT
<213>  Homo sapiens

<400>  788

Met Gly Gly Ala Cys Ser Ser Phe Thr Thr Ser Ser Ser Pro Thr Ile 
1               5                   10                  15      


Tyr Ser Thr Ser Val Thr Asp Ser Lys Ala Met Gln Val Glu Ser Cys 
            20                  25                  30          


Ser Ser Ala Val Gly Val Ser Asn Arg Gly Val Ser Glu Lys Gln Leu 
        35                  40                  45              


Thr Ser Asn Thr Val Gln Gln His Pro Ser Thr Pro Lys Arg His Thr 
    50                  55                  60                  


Val Leu Tyr Ile Ser Pro Pro Pro Glu Asp Leu Leu Asp Asn Ser Arg 
65                  70                  75                  80  


Met Ser Cys Gln Asp Glu Gly Cys Gly Leu Glu Ser Glu Gln Ser Cys 
                85                  90                  95      


Ser Met Trp Met Glu Asp Ser Pro Ser Asn Phe Ser Asn Met Ser Thr 
            100                 105                 110         


Ser Ser Tyr Asn Asp Asn Thr Glu Val Pro Arg Lys Ser Arg Lys Arg 
        115                 120                 125             


Asn Pro Lys Gln Arg Pro Gly Val Lys Arg Arg Asp Cys Glu Glu Ser 
    130                 135                 140                 


Asn Met Asp Ile Phe Asp Ala Asp Ser Ala Lys Ala Pro His Tyr Val 
145                 150                 155                 160 


Leu Ser Gln Leu Thr Thr Asp Asn Lys Gly Asn Ser Lys Ala Gly Asn 
                165                 170                 175     


Gly Thr Leu Glu Asn Gln Lys Gly Thr Gly Val Lys Lys Ser Pro Met 
            180                 185                 190         


Leu Cys Gly Gln Tyr Pro Val Lys Ser Glu Gly Lys Glu Leu Lys Ile 
        195                 200                 205             


Val Val Gln Pro Glu Thr Gln His Arg Ala Arg Tyr Leu Thr Glu Gly 
    210                 215                 220                 


Ser Arg Gly Ser Val Lys Asp Arg Thr Gln Gln Gly Phe Pro Thr Val 
225                 230                 235                 240 


Lys Leu Glu Gly His Asn Glu Pro Val Val Leu Gln Val Phe Val Gly 
                245                 250                 255     


Asn Asp Ser Gly Arg Val Lys Pro His Gly Phe Tyr Gln Ala Cys Arg 
            260                 265                 270         


Val Thr Gly Arg Asn Thr Thr Pro Cys Lys Glu Val Asp Ile Glu Gly 
        275                 280                 285             


Thr Thr Val Ile Glu Val Gly Leu Asp Pro Ser Asn Asn Met Thr Leu 
    290                 295                 300                 


Ala Val Asp Cys Val Gly Ile Leu Lys Leu Arg Asn Ala Asp Val Glu 
305                 310                 315                 320 


Ala Arg Ile Gly Ile Ala Gly Ser Lys Lys Lys Ser Thr Arg Ala Arg 
                325                 330                 335     


Leu Val Phe Arg Val Asn Ile Met Arg Lys Asp Gly Ser Thr Leu Thr 
            340                 345                 350         


Leu Gln Thr Pro Ser Ser Pro Ile Leu Cys Thr Gln Pro Ala Gly Val 
        355                 360                 365             


Pro Glu Ile Leu Lys Lys Ser Leu His Ser Cys Ser Val Lys Gly Glu 
    370                 375                 380                 


Glu Glu Val Phe Leu Ile Gly Lys Asn Phe Leu Lys Gly Thr Lys Val 
385                 390                 395                 400 


Ile Phe Gln Glu Asn Val Ser Asp Glu Asn Ser Trp Lys Ser Glu Ala 
                405                 410                 415     


Glu Ile Asp Met Glu Leu Phe His Gln Asn His Leu Ile Val Lys Val 
            420                 425                 430         


Pro Pro Tyr His Asp Gln His Ile Thr Leu Pro Val Ser Val Gly Ile 
        435                 440                 445             


Tyr Val Val Thr Asn Ala Gly Arg Ser His Asp Val Gln Pro Phe Thr 
    450                 455                 460                 


Tyr Thr Pro Asp Pro Ala Ala Ala Gly Ala Leu Asn Val Asn Val Lys 
465                 470                 475                 480 


Lys Glu Ile Ser Ser Pro Ala Arg Pro Cys Ser Phe Glu Glu Ala Met 
                485                 490                 495     


Lys Ala Met Lys Thr Thr Gly Cys Asn Leu Asp Lys Val Asn Ile Ile 
            500                 505                 510         


Pro Asn Ala Leu Met Thr Pro Leu Ile Pro Ser Ser Met Ile Lys Ser 
        515                 520                 525             


Glu Asp Val Thr Pro Met Glu Val Thr Ala Glu Lys Arg Ser Ser Thr 
    530                 535                 540                 


Ile Phe Lys Thr Thr Lys Ser Val Gly Ser Thr Gln Gln Thr Leu Glu 
545                 550                 555                 560 


Asn Ile Ser Asn Ile Ala Gly Asn Gly Ser Phe Ser Ser Pro Ser Ser 
                565                 570                 575     


Ser His Leu Pro Ser Glu Asn Glu Lys Gln Gln Gln Ile Gln Pro Lys 
            580                 585                 590         


Ala Tyr Asn Pro Glu Thr Leu Thr Thr Ile Gln Thr Gln Asp Ile Ser 
        595                 600                 605             


Gln Pro Gly Thr Phe Pro Ala Val Ser Ala Ser Ser Gln Leu Pro Asn 
    610                 615                 620                 


Ser Asp Ala Leu Leu Gln Gln Ala Thr Gln Phe Gln Thr Arg Glu Thr 
625                 630                 635                 640 


Gln Ser Arg Glu Ile Leu Gln Ser Asp Gly Thr Val Val Asn Leu Ser 
                645                 650                 655     


Gln Leu Thr Glu Ala Ser Gln Gln Gln Gln Gln Ser Pro Leu Gln Glu 
            660                 665                 670         


Gln Ala Gln Thr Leu Gln Gln Gln Ile Ser Ser Asn Ile Phe Pro Ser 
        675                 680                 685             


Pro Asn Ser Val Ser Gln Leu Gln Asn Thr Ile Gln Gln Leu Gln Ala 
    690                 695                 700                 


Gly Ser Phe Thr Gly Ser Thr Ala Ser Gly Ser Ser Gly Ser Val Asp 
705                 710                 715                 720 


Leu Val Gln Gln Val Leu Glu Ala Gln Gln Gln Leu Ser Ser Val Leu 
                725                 730                 735     


Phe Ser Ala Pro Asp Gly Asn Glu Asn Val Gln Glu Gln Leu Ser Ala 
            740                 745                 750         


Asp Ile Phe Gln Gln Val Ser Gln Ile Gln Ser Gly Val Ser Pro Gly 
        755                 760                 765             


Met Phe Ser Ser Thr Glu Pro Thr Val His Thr Arg Pro Asp Asn Leu 
    770                 775                 780                 


Leu Pro Gly Arg Ala Glu Ser Val His Pro Gln Ser Glu Asn Thr Leu 
785                 790                 795                 800 


Ser Asn Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Val Met Glu Ser 
                805                 810                 815     


Ser Ala Ala Met Val Met Glu Met Gln Gln Ser Ile Cys Gln Ala Ala 
            820                 825                 830         


Ala Gln Ile Gln Ser Glu Leu Phe Pro Ser Thr Ala Ser Ala Asn Gly 
        835                 840                 845             


Asn Leu Gln Gln Ser Pro Val Tyr Gln Gln Thr Ser His Met Met Ser 
    850                 855                 860                 


Ala Leu Ser Thr Asn Glu Asp Met Gln Met Gln Cys Glu Leu Phe Ser 
865                 870                 875                 880 


Ser Pro Pro Ala Val Ser Gly Asn Glu Thr Ser Thr Thr Thr Thr Gln 
                885                 890                 895     


Gln Val Ala Thr Pro Gly Thr Thr Met Phe Gln Thr Ser Ser Ser Gly 
            900                 905                 910         


Asp Gly Glu Glu Thr Gly Thr Gln Ala Lys Gln Ile Gln Asn Ser Val 
        915                 920                 925             


Phe Gln Thr Met Val Gln Met Gln His Ser Gly Asp Asn Gln Pro Gln 
    930                 935                 940                 


Val Asn Leu Phe Ser Ser Thr Lys Ser Met Met Ser Val Gln Asn Ser 
945                 950                 955                 960 


Gly Thr Gln Gln Gln Gly Asn Gly Leu Phe Gln Gln Gly Asn Glu Met 
                965                 970                 975     


Met Ser Leu Gln Ser Gly Asn Phe Leu Gln Gln Ser Ser His Ser Gln 
            980                 985                 990         


Ala Gln Leu Phe His Pro Gln Asn  Pro Ile Ala Asp Ala  Gln Asn Leu 
        995                 1000                 1005             


Ser Gln  Glu Thr Gln Gly Ser  Leu Phe His Ser Pro  Asn Pro Ile 
    1010                 1015                 1020             


Val His  Ser Gln Thr Ser Thr  Thr Ser Ser Glu Gln  Met Gln Pro 
    1025                 1030                 1035             


Pro Met  Phe His Ser Gln Ser  Thr Ile Ala Val Leu  Gln Gly Ser 
    1040                 1045                 1050             


Ser Val  Pro Gln Asp Gln Gln  Ser Thr Asn Ile Phe  Leu Ser Gln 
    1055                 1060                 1065             


Ser Pro  Met Asn Asn Leu Gln  Thr Asn Thr Val Ala  Gln Glu Ala 
    1070                 1075                 1080             


Phe Phe  Ala Ala Pro Asn Ser  Ile Ser Pro Leu Gln  Ser Thr Ser 
    1085                 1090                 1095             


Asn Ser  Glu Gln Gln Ala Ala  Phe Gln Gln Gln Ala  Pro Ile Ser 
    1100                 1105                 1110             


His Ile  Gln Thr Pro Met Leu  Ser Gln Glu Gln Ala  Gln Pro Pro 
    1115                 1120                 1125             


Gln Gln  Gly Leu Phe Gln Pro  Gln Val Ala Leu Gly  Ser Leu Pro 
    1130                 1135                 1140             


Pro Asn  Pro Met Pro Gln Ser  Gln Gln Gly Thr Met  Phe Gln Ser 
    1145                 1150                 1155             


Gln His  Ser Ile Val Ala Met  Gln Ser Asn Ser Pro  Ser Gln Glu 
    1160                 1165                 1170             


Gln Gln  Gln Gln Gln Gln Gln  Gln Gln Gln Gln Gln  Gln Gln Gln 
    1175                 1180                 1185             


Gln Gln  Ser Ile Leu Phe Ser  Asn Gln Asn Thr Met  Ala Thr Met 
    1190                 1195                 1200             


Ala Ser  Pro Lys Gln Pro Pro  Pro Asn Met Ile Phe  Asn Pro Asn 
    1205                 1210                 1215             


Gln Asn  Pro Met Ala Asn Gln  Glu Gln Gln Asn Gln  Ser Ile Phe 
    1220                 1225                 1230             


His Gln  Gln Ser Asn Met Ala  Pro Met Asn Gln Glu  Gln Gln Pro 
    1235                 1240                 1245             


Met Gln  Phe Gln Ser Gln Ser  Thr Val Ser Ser Leu  Gln Asn Pro 
    1250                 1255                 1260             


Gly Pro  Thr Gln Ser Glu Ser  Ser Gln Thr Pro Leu  Phe His Ser 
    1265                 1270                 1275             


Ser Pro  Gln Ile Gln Leu Val  Gln Gly Ser Pro Ser  Ser Gln Glu 
    1280                 1285                 1290             


Gln Gln  Val Thr Leu Phe Leu  Ser Pro Ala Ser Met  Ser Ala Leu 
    1295                 1300                 1305             


Gln Thr  Ser Ile Asn Gln Gln  Asp Met Gln Gln Ser  Pro Leu Tyr 
    1310                 1315                 1320             


Ser Pro  Gln Asn Asn Met Pro  Gly Ile Gln Gly Ala  Thr Ser Ser 
    1325                 1330                 1335             


Pro Gln  Pro Gln Ala Thr Leu  Phe His Asn Thr Ala  Gly Gly Thr 
    1340                 1345                 1350             


Met Asn  Gln Leu Gln Asn Ser  Pro Gly Ser Ser Gln  Gln Thr Ser 
    1355                 1360                 1365             


Gly Met  Phe Leu Phe Gly Ile  Gln Asn Asn Cys Ser  Gln Leu Leu 
    1370                 1375                 1380             


Thr Ser  Gly Pro Ala Thr Leu  Pro Asp Gln Leu Met  Ala Ile Ser 
    1385                 1390                 1395             


Gln Pro  Gly Gln Pro Gln Asn  Glu Gly Gln Pro Pro  Val Thr Thr 
    1400                 1405                 1410             


Leu Leu  Ser Gln Gln Met Pro  Glu Asn Ser Pro Leu  Ala Ser Ser 
    1415                 1420                 1425             


Ile Asn  Thr Asn Gln Asn Ile  Glu Lys Ile Asp Leu  Leu Val Ser 
    1430                 1435                 1440             


Leu Gln  Asn Gln Gly Asn Asn  Leu Thr Gly Ser Phe  
    1445                 1450                 1455 


<210>  789
<211>  1455
<212>  PRT
<213>  Homo sapiens

<400>  789

Met Gly Gly Ala Cys Ser Ser Phe Thr Thr Ser Ser Ser Pro Thr Ile 
1               5                   10                  15      


Tyr Ser Thr Ser Val Thr Asp Ser Lys Ala Met Gln Val Glu Ser Cys 
            20                  25                  30          


Ser Ser Ala Val Gly Val Ser Asn Arg Gly Val Ser Glu Lys Gln Leu 
        35                  40                  45              


Thr Ser Asn Thr Val Gln Gln His Pro Ser Thr Pro Lys Arg His Thr 
    50                  55                  60                  


Val Leu Tyr Ile Ser Pro Pro Pro Glu Asp Leu Leu Asp Asn Ser Arg 
65                  70                  75                  80  


Met Ser Cys Gln Asp Glu Gly Cys Gly Leu Glu Ser Glu Gln Ser Cys 
                85                  90                  95      


Ser Met Trp Met Glu Asp Ser Pro Ser Asn Phe Ser Asn Met Ser Thr 
            100                 105                 110         


Ser Ser Tyr Asn Asp Asn Thr Glu Val Pro Arg Lys Ser Arg Lys Arg 
        115                 120                 125             


Asn Pro Lys Gln Arg Pro Gly Val Lys Arg Arg Asp Cys Glu Glu Ser 
    130                 135                 140                 


Asn Met Asp Ile Phe Asp Ala Asp Ser Ala Lys Ala Pro His Tyr Val 
145                 150                 155                 160 


Leu Ser Gln Leu Thr Thr Asp Asn Lys Gly Asn Ser Lys Ala Gly Asn 
                165                 170                 175     


Gly Thr Leu Glu Asn Gln Lys Gly Thr Gly Val Lys Lys Ser Pro Met 
            180                 185                 190         


Leu Cys Gly Gln Tyr Pro Val Lys Ser Glu Gly Lys Glu Leu Lys Ile 
        195                 200                 205             


Val Val Gln Pro Glu Thr Gln His Arg Ala Arg Tyr Leu Thr Glu Gly 
    210                 215                 220                 


Ser Arg Gly Ser Val Lys Asp Arg Thr Gln Gln Gly Phe Pro Thr Val 
225                 230                 235                 240 


Lys Leu Glu Gly His Asn Glu Pro Val Val Leu Gln Val Phe Val Gly 
                245                 250                 255     


Asn Asp Ser Gly Arg Val Lys Pro His Gly Phe Tyr Gln Ala Cys Arg 
            260                 265                 270         


Val Thr Gly Arg Asn Thr Thr Pro Cys Lys Glu Val Asp Ile Glu Gly 
        275                 280                 285             


Thr Thr Val Ile Glu Val Gly Leu Asp Pro Ser Asn Asn Met Thr Leu 
    290                 295                 300                 


Ala Val Asp Cys Val Gly Ile Leu Lys Leu Arg Asn Ala Asp Val Glu 
305                 310                 315                 320 


Ala Arg Ile Gly Ile Ala Gly Ser Lys Lys Lys Ser Thr Arg Ala Arg 
                325                 330                 335     


Leu Val Phe Arg Val Asn Ile Met Arg Lys Asp Gly Ser Thr Leu Thr 
            340                 345                 350         


Leu Gln Thr Pro Ser Ser Pro Ile Leu Cys Thr Gln Pro Ala Gly Val 
        355                 360                 365             


Pro Glu Ile Leu Lys Lys Ser Leu His Ser Cys Ser Val Lys Gly Glu 
    370                 375                 380                 


Glu Glu Val Phe Leu Ile Gly Lys Asn Phe Leu Lys Gly Thr Lys Val 
385                 390                 395                 400 


Ile Phe Gln Glu Asn Val Ser Asp Glu Asn Ser Trp Lys Ser Glu Ala 
                405                 410                 415     


Glu Ile Asp Met Glu Leu Phe His Gln Asn His Leu Ile Val Lys Val 
            420                 425                 430         


Pro Pro Tyr His Asp Gln His Ile Thr Leu Pro Val Ser Val Gly Ile 
        435                 440                 445             


Tyr Val Val Thr Asn Ala Gly Arg Ser His Asp Val Gln Pro Phe Thr 
    450                 455                 460                 


Tyr Thr Pro Asp Pro Ala Ala Ala Gly Ala Leu Asn Val Asn Val Lys 
465                 470                 475                 480 


Lys Glu Ile Ser Ser Pro Ala Arg Pro Cys Ser Phe Glu Glu Ala Met 
                485                 490                 495     


Lys Ala Met Lys Thr Thr Gly Cys Asn Leu Asp Lys Val Asn Ile Ile 
            500                 505                 510         


Pro Asn Ala Leu Met Thr Pro Leu Ile Pro Ser Ser Met Ile Lys Ser 
        515                 520                 525             


Glu Asp Val Thr Pro Met Glu Val Thr Ala Glu Lys Arg Ser Ser Thr 
    530                 535                 540                 


Ile Phe Lys Thr Thr Lys Ser Val Gly Ser Thr Gln Gln Thr Leu Glu 
545                 550                 555                 560 


Asn Ile Ser Asn Ile Ala Gly Asn Gly Ser Phe Ser Ser Pro Ser Ser 
                565                 570                 575     


Ser His Leu Pro Ser Glu Asn Glu Lys Gln Gln Gln Ile Gln Pro Lys 
            580                 585                 590         


Ala Tyr Asn Pro Glu Thr Leu Thr Thr Ile Gln Thr Gln Asp Ile Ser 
        595                 600                 605             


Gln Pro Gly Thr Phe Pro Ala Val Ser Ala Ser Ser Gln Leu Pro Asn 
    610                 615                 620                 


Ser Asp Ala Leu Leu Gln Gln Ala Thr Gln Phe Gln Thr Arg Glu Thr 
625                 630                 635                 640 


Gln Ser Arg Glu Ile Leu Gln Ser Asp Gly Thr Val Val Asn Leu Ser 
                645                 650                 655     


Gln Leu Thr Glu Ala Ser Gln Gln Gln Gln Gln Ser Pro Leu Gln Glu 
            660                 665                 670         


Gln Ala Gln Thr Leu Gln Gln Gln Ile Ser Ser Asn Ile Phe Pro Ser 
        675                 680                 685             


Pro Asn Ser Val Ser Gln Leu Gln Asn Thr Ile Gln Gln Leu Gln Ala 
    690                 695                 700                 


Gly Ser Phe Thr Gly Ser Thr Ala Ser Gly Ser Ser Gly Ser Val Asp 
705                 710                 715                 720 


Leu Val Gln Gln Val Leu Glu Ala Gln Gln Gln Leu Ser Ser Val Leu 
                725                 730                 735     


Phe Ser Ala Pro Asp Gly Asn Glu Asn Val Gln Glu Gln Leu Ser Ala 
            740                 745                 750         


Asp Ile Phe Gln Gln Val Ser Gln Ile Gln Ser Gly Val Ser Pro Gly 
        755                 760                 765             


Met Phe Ser Ser Thr Glu Pro Thr Val His Thr Arg Pro Asp Asn Leu 
    770                 775                 780                 


Leu Pro Gly Arg Ala Glu Ser Val His Pro Gln Ser Glu Asn Thr Leu 
785                 790                 795                 800 


Ser Asn Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Val Met Glu Ser 
                805                 810                 815     


Ser Ala Ala Met Val Met Glu Met Gln Gln Ser Ile Cys Gln Ala Ala 
            820                 825                 830         


Ala Gln Ile Gln Ser Glu Leu Phe Pro Ser Thr Ala Ser Ala Asn Gly 
        835                 840                 845             


Asn Leu Gln Gln Ser Pro Val Tyr Gln Gln Thr Ser His Met Met Ser 
    850                 855                 860                 


Ala Leu Ser Thr Asn Glu Asp Met Gln Met Gln Cys Glu Leu Phe Ser 
865                 870                 875                 880 


Ser Pro Pro Ala Val Ser Gly Asn Glu Thr Ser Thr Thr Thr Thr Gln 
                885                 890                 895     


Gln Val Ala Thr Pro Gly Thr Thr Met Phe Gln Thr Ser Ser Ser Gly 
            900                 905                 910         


Asp Gly Glu Glu Thr Gly Thr Gln Ala Lys Gln Ile Gln Asn Ser Val 
        915                 920                 925             


Phe Gln Thr Met Val Gln Met Gln His Ser Gly Asp Asn Gln Pro Gln 
    930                 935                 940                 


Val Asn Leu Phe Ser Ser Thr Lys Ser Met Met Ser Val Gln Asn Ser 
945                 950                 955                 960 


Gly Thr Gln Gln Gln Gly Asn Gly Leu Phe Gln Gln Gly Asn Glu Met 
                965                 970                 975     


Met Ser Leu Gln Ser Gly Asn Phe Leu Gln Gln Ser Ser His Ser Gln 
            980                 985                 990         


Ala Gln Leu Phe His Pro Gln Asn  Pro Ile Ala Asp Ala  Gln Asn Leu 
        995                 1000                 1005             


Ser Gln  Glu Thr Gln Gly Ser  Leu Phe His Ser Pro  Asn Pro Ile 
    1010                 1015                 1020             


Val His  Ser Gln Thr Ser Thr  Thr Ser Ser Glu Gln  Met Gln Pro 
    1025                 1030                 1035             


Pro Met  Phe His Ser Gln Ser  Thr Ile Ala Val Leu  Gln Gly Ser 
    1040                 1045                 1050             


Ser Val  Pro Gln Asp Gln Gln  Ser Thr Asn Ile Phe  Leu Ser Gln 
    1055                 1060                 1065             


Ser Pro  Met Asn Asn Leu Gln  Thr Asn Thr Val Ala  Gln Glu Ala 
    1070                 1075                 1080             


Phe Phe  Ala Ala Pro Asn Ser  Ile Ser Pro Leu Gln  Ser Thr Ser 
    1085                 1090                 1095             


Asn Ser  Glu Gln Gln Ala Ala  Phe Gln Gln Gln Ala  Pro Ile Ser 
    1100                 1105                 1110             


His Ile  Gln Thr Pro Met Leu  Ser Gln Glu Gln Ala  Gln Pro Pro 
    1115                 1120                 1125             


Gln Gln  Gly Leu Phe Gln Pro  Gln Val Ala Leu Gly  Ser Leu Pro 
    1130                 1135                 1140             


Pro Asn  Pro Met Pro Gln Ser  Gln Gln Gly Thr Met  Phe Gln Ser 
    1145                 1150                 1155             


Gln His  Ser Ile Val Ala Met  Gln Ser Asn Ser Pro  Ser Gln Glu 
    1160                 1165                 1170             


Gln Gln  Gln Gln Gln Gln Gln  Gln Gln Gln Gln Gln  Gln Gln Gln 
    1175                 1180                 1185             


Gln Gln  Ser Ile Leu Phe Ser  Asn Gln Asn Thr Met  Ala Thr Met 
    1190                 1195                 1200             


Ala Ser  Pro Lys Gln Pro Pro  Pro Asn Met Ile Phe  Asn Pro Asn 
    1205                 1210                 1215             


Gln Asn  Pro Met Ala Asn Gln  Glu Gln Gln Asn Gln  Ser Ile Phe 
    1220                 1225                 1230             


His Gln  Gln Ser Asn Met Ala  Pro Met Asn Gln Glu  Gln Gln Pro 
    1235                 1240                 1245             


Met Gln  Phe Gln Ser Gln Ser  Thr Val Ser Ser Leu  Gln Asn Pro 
    1250                 1255                 1260             


Gly Pro  Thr Gln Ser Glu Ser  Ser Gln Thr Pro Leu  Phe His Ser 
    1265                 1270                 1275             


Ser Pro  Gln Ile Gln Leu Val  Gln Gly Ser Pro Ser  Ser Gln Glu 
    1280                 1285                 1290             


Gln Gln  Val Thr Leu Phe Leu  Ser Pro Ala Ser Met  Ser Ala Leu 
    1295                 1300                 1305             


Gln Thr  Ser Ile Asn Gln Gln  Asp Met Gln Gln Ser  Pro Leu Tyr 
    1310                 1315                 1320             


Ser Pro  Gln Asn Asn Met Pro  Gly Ile Gln Gly Ala  Thr Ser Ser 
    1325                 1330                 1335             


Pro Gln  Pro Gln Ala Thr Leu  Phe His Asn Thr Ala  Gly Gly Thr 
    1340                 1345                 1350             


Met Asn  Gln Leu Gln Asn Ser  Pro Gly Ser Ser Gln  Gln Thr Ser 
    1355                 1360                 1365             


Gly Met  Phe Leu Phe Gly Ile  Gln Asn Asn Cys Ser  Gln Leu Leu 
    1370                 1375                 1380             


Thr Ser  Gly Pro Ala Thr Leu  Pro Asp Gln Leu Met  Ala Ile Ser 
    1385                 1390                 1395             


Gln Pro  Gly Gln Pro Gln Asn  Glu Gly Gln Pro Pro  Val Thr Thr 
    1400                 1405                 1410             


Leu Leu  Ser Gln Gln Met Pro  Glu Asn Ser Pro Leu  Ala Ser Ser 
    1415                 1420                 1425             


Ile Asn  Thr Asn Gln Asn Ile  Glu Lys Ile Asp Leu  Leu Val Ser 
    1430                 1435                 1440             


Leu Gln  Asn Gln Gly Asn Asn  Leu Thr Gly Ser Phe  
    1445                 1450                 1455 


<210>  790
<211>  141
<212>  PRT
<213>  Homo sapiens

<400>  790

Ala Met Gln Val Glu Ser Cys Ser Ser Ala Val Gly Asn Asn Met Pro 
1               5                   10                  15      


Gly Ile Gln Gly Ala Thr Ser Ser Pro Gln Pro Gln Ala Thr Leu Phe 
            20                  25                  30          


His Asn Thr Ala Gly Gly Thr Met Asn Gln Leu Gln Asn Ser Pro Gly 
        35                  40                  45              


Ser Ser Gln Gln Thr Ser Gly Met Phe Leu Phe Gly Ile Gln Asn Asn 
    50                  55                  60                  


Cys Ser Gln Leu Leu Thr Ser Gly Pro Ala Thr Leu Pro Asp Gln Leu 
65                  70                  75                  80  


Met Ala Ile Ser Gln Pro Gly Gln Pro Gln Asn Glu Gly Gln Pro Pro 
                85                  90                  95      


Val Thr Thr Leu Leu Ser Gln Gln Met Pro Glu Asn Ser Pro Leu Ala 
            100                 105                 110         


Ser Ser Ile Asn Thr Asn Gln Asn Ile Glu Lys Ile Asp Leu Leu Val 
        115                 120                 125             


Ser Leu Gln Asn Gln Gly Asn Asn Leu Thr Gly Ser Phe 
    130                 135                 140     


<210>  791
<211>  143
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  791

Xaa Thr Leu Glu Asn Gln Lys Gly Thr Gly Val Lys Lys Ser Pro Met 
1               5                   10                  15      


Leu Cys Gly Gln Tyr Pro Val Lys Ser Glu Gly Lys Glu Leu Lys Ile 
            20                  25                  30          


Val Val Gln Pro Glu Thr Gln His Arg Ala Arg Tyr Leu Thr Glu Gly 
        35                  40                  45              


Ser Arg Gly Ser Val Lys Asp Arg Thr Gln Gln Gly Phe Pro Thr Val 
    50                  55                  60                  


Lys Leu Glu Gly His Asn Glu Pro Val Val Leu Gln Val Phe Val Gly 
65                  70                  75                  80  


Asn Asp Ser Gly Arg Val Lys Pro His Gly Phe Tyr Gln Ala Cys Arg 
                85                  90                  95      


Val Thr Gly Arg Asn Thr Thr Pro Cys Lys Glu Val Asp Ile Glu Gly 
            100                 105                 110         


Thr Thr Val Ile Glu Val Gly Leu Asp Pro Ser Asn Asn Met Thr Leu 
        115                 120                 125             


Ala Ser Ala Ser Arg Ser Ala Arg Asn Leu Lys Glu Lys Leu Ala 
    130                 135                 140             


