                         SEQUENCE LISTING

<110>  ݣƼ޹˾
 
<120>  PD-L1Դ¡弰Ӧ

<130>  2016

<160>  56    

<170>  PatentIn version 3.3

<210>  1
<211>  363
<212>  DNA
<213>  ˹

<400>  1
aaggtccagc tgcagcagtc tggagctgag ctggtgaaac ccggggcatc agtgaagctg     60

tcctgcaagg cttctggcta caccttcact aaatatatta tacactggat aaagcagagg    120

tctggacagg gtcttgagtg gattgggtgg ttttaccctg gaagtggtaa tatcaggtac    180

aatgagaaaa tcaagggcaa ggccacattg actgcggaca aatcctccag cacagtctat    240

atggagctta gtggattgac atctgaggac tctgcggtct atttctgtgc aagacacggg    300

gaactgggag gcggttactt ctttgactac tggggccaag gcaccactct cacggtctcc    360

tca                                                                  363


<210>  2
<211>  107
<212>  PRT
<213>  ˹

<400>  2

Gln Ile Val Leu Ser Gln Ser Pro Thr Ile Leu Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val Ser Asn Ile 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Thr Gly Ser Ser Pro Lys Pro Trp Ile Tyr 
        35                  40                  45              


Ala Thr Ser Asn Leu Ala Ser Gly Ala Pro Val Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Val Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Leu Thr 
                85                  90                  95      


Phe Gly Pro Gly Thr Lys Leu Glu Leu Lys Arg 
            100                 105         


<210>  3
<211>  321
<212>  DNA
<213>  ˹

<400>  3
caaattgttc tctcccagtc tccaacaatc ctgtctgcat ctccagggga gaaggtcaca     60

atgacttgca gggccagctc cagtgtaagt aacatacact ggtaccagca gaagacagga    120

tcctccccca aaccctggat ttatgccaca tccaacctgg cttctggagc ccctgttcgc    180

ttcagtggca gtgggtctgg gacctcttat tctctcacaa tcagcagagt ggaggctgaa    240

gatgctgcca cttattactg ccagcagtgg agtagtaacc cactcacgtt cggtcctggg    300

accaagctgg agctgaaacg g                                              321


<210>  4
<211>  121
<212>  PRT
<213>  ˹

<400>  4

Lys Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Lys Tyr 
            20                  25                  30          


Ile Ile His Trp Ile Lys Gln Arg Ser Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Phe Tyr Pro Gly Ser Gly Asn Ile Arg Tyr Asn Glu Lys Ile 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Gly Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg His Gly Glu Leu Gly Gly Gly Tyr Phe Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Leu Thr Val Ser Ser 
        115                 120     


<210>  5
<211>  363
<212>  DNA
<213>  ˹

<400>  5
gaggtgcagc tggtgcagag cggcgccgag gtgaagaaac ctggcgcctc cgtgaaggtg     60

agctgcaagg cctccggcta caccttcacc aagtacatca tccactgggt gcggcaagcc    120

cctggacagg gactggaatg gatgggctgg ttctaccctg gttctggcaa catccggtac    180

aacgagaaga tcaagggcag ggtgaccatg acccgggaca ccagcacctc caccgtgtac    240

atggagctgt cctccctgag gagcgaggac accgccgtgt attactgcgc taggcacgga    300

gagctgggcg gaggctactt cttcgactac tggggccagg gcacaaccgt gaccgtgtcc    360

tcc                                                                  363


<210>  6
<211>  121
<212>  PRT
<213>  ˹

<400>  6

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Lys Tyr 
            20                  25                  30          


Ile Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Phe Tyr Pro Gly Ser Gly Asn Ile Arg Tyr Asn Glu Lys Ile 
    50                  55                  60                  


Lys Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg His Gly Glu Leu Gly Gly Gly Tyr Phe Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120     


<210>  7
<211>  321
<212>  DNA
<213>  ˹

<400>  7
gatatccagc tgacccagag cccctccttt ctgtccgcct ccgtgggcga cagggtgacc     60

atcacctgca gggccagctc cagcgtgagc aacatccact ggtatcaaca gaagcctggc    120

aaggccccca agccctggat ctacgccacc tccaacctgg ccagcggcgt gcctagcagg    180

ttcagcggtt ctggctccgg caccgagttc accctgacca tctcctccct gcagcccgag    240

gacttcgcca cctactactg ccagcagtgg tccagcaacc ccctgacctt tggccagggc    300

accaagctgg agatcaagag g                                              321


<210>  8
<211>  107
<212>  PRT
<213>  ˹

<400>  8

Asp Ile Gln Leu Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Ser Ser Val Ser Asn Ile 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Pro Trp Ile Tyr 
        35                  40                  45              


Ala Thr Ser Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
65                  70                  75                  80  


Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Leu Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105         


<210>  9
<211>  1359
<212>  DNA
<213>  ˹

<400>  9
gaggtgcagc tggtgcagag cggcgccgag gtgaagaaac ctggcgcctc cgtgaaggtg     60

agctgcaagg cctccggcta caccttcacc aagtacatca tccactgggt gcggcaagcc    120

cctggacagg gactggaatg gatgggctgg ttctaccctg gttctggcaa catccggtac    180

aacgagaaga tcaagggcag ggtgaccatg acccgggaca ccagcacctc caccgtgtac    240

atggagctgt cctccctgag gagcgaggac accgccgtgt attactgcgc taggcacgga    300

gagctgggcg gaggctactt cttcgactac tggggccagg gcacaaccgt gaccgtgtcc    360

tccgccagca ccaagggacc atccgtgttc ccactggctc caagctctaa atccactagc    420

ggaggcaccg cagccctggg atgtctggtg aaggattact tcccagagcc cgtcacagtg    480

tcatggaact ccggggctct gacctctggt gtccacacat ttccagcagt gctgcagagt    540

tcaggcctgt actccctgtc cagcgtggtc acagtgccct ctagttcact gggaactcag    600

acctatatct gcaacgtgaa tcacaagcca tccaatacta aagtcgacaa gaaagtggag    660

cccaagagct gtgataaaac acatacttgc cccccttgtc ctgcaccaga actgctggga    720

ggaccatccg tgttcctgtt tccacccaag cctaaagaca ctctgatgat ttctcgaaca    780

cccgaggtca cttgcgtggt cgtggacgtg tcccacgagg atcctgaagt caagtttaac    840

tggtacgtgg atggagtcga agtgcataat gctaagacaa aacctagaga ggaacagtac    900

gccagtacat atagagtcgt gtcagtcctg actgtgctgc atcaggactg gctgaacggg    960

aaggagtata agtgcaaagt gtccaataag gctctgcccg cacctatcga gaaaactatt   1020

agcaaggcta aaggccagcc tagggaacca caggtgtaca ccctgcctcc atctcgggag   1080

gaaatgacta agaaccaggt cagtctgacc tgtctggtga aaggcttcta tccttccgac   1140

atcgcagtgg agtgggaaag caatggacag ccagagaaca attacaagac cacaccccct   1200

gtgctggaca gcgatgggtc tttctttctg tatagtaagc tgaccgtgga taaatcacgg   1260

tggcagcagg gtaatgtctt ttcttgtagt gtgatgcacg aagccctgca caaccattac   1320

actcagaaat ccctgtcact gtcccctgga aagtgataa                          1359


<210>  10
<211>  401
<212>  PRT
<213>  ˹

<400>  10

Phe Tyr Pro Gly Ser Gly Asn Ile Arg Tyr Asn Glu Lys Ile Lys Gly 
1               5                   10                  15      


Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr Met Glu 
            20                  25                  30          


Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
        35                  40                  45              


His Gly Glu Leu Gly Gly Gly Tyr Phe Phe Asp Tyr Trp Gly Gln Gly 
    50                  55                  60                  


Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
65                  70                  75                  80  


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
                85                  90                  95      


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
            100                 105                 110         


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
        115                 120                 125             


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
    130                 135                 140                 


Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
145                 150                 155                 160 


Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys 
                165                 170                 175     


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
            180                 185                 190         


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
        195                 200                 205             


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
    210                 215                 220                 


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
225                 230                 235                 240 


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Ala Ser Thr Tyr Arg Val 
                245                 250                 255     


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
            260                 265                 270         


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
        275                 280                 285             


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
    290                 295                 300                 


Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
305                 310                 315                 320 


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
                325                 330                 335     


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
            340                 345                 350         


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
        355                 360                 365             


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
    370                 375                 380                 


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
385                 390                 395                 400 


Lys 
    


<210>  11
<211>  15
<212>  DNA
<213>  ˹

<400>  11
aagtacatca tccac                                                      15


<210>  12
<211>  51
<212>  DNA
<213>  ˹

<400>  12
tggttctacc ctggttctgg caacatccgg tacaacgaga agatcaaggg c              51


<210>  13
<211>  36
<212>  DNA
<213>  ˹

<400>  13
cacggagagc tgggcggagg ctacttcttc gactac                               36


<210>  14
<211>  90
<212>  DNA
<213>  ˹

<400>  14
gaggtgcagc tggtgcagag cggcgccgag gtgaagaaac ctggcgcctc cgtgaaggtg     60

agctgcaagg cctccggcta caccttcacc                                      90


<210>  15
<211>  42
<212>  DNA
<213>  ˹

<400>  15
tgggtgcggc aagcccctgg acagggactg gaatggatgg gc                        42


<210>  16
<211>  96
<212>  DNA
<213>  ˹

<400>  16
agggtgacca tgacccggga caccagcacc tccaccgtgt acatggagct gtcctccctg     60

aggagcgagg acaccgccgt gtattactgc gctagg                               96


<210>  17
<211>  33
<212>  DNA
<213>  ˹

<400>  17
tggggccagg gcacaaccgt gaccgtgtcc tcc                                  33


<210>  18
<211>  5
<212>  PRT
<213>  ˹

<400>  18

Lys Tyr Ile Ile His 
1               5   


<210>  19
<211>  17
<212>  PRT
<213>  ˹

<400>  19

Trp Phe Tyr Pro Gly Ser Gly Asn Ile Arg Tyr Asn Glu Lys Ile Lys 
1               5                   10                  15      


Gly 
    


<210>  20
<211>  12
<212>  PRT
<213>  ˹

<400>  20

His Gly Glu Leu Gly Gly Gly Tyr Phe Phe Asp Tyr 
1               5                   10          


<210>  21
<211>  30
<212>  PRT
<213>  ˹

<400>  21

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr 
            20                  25                  30  


<210>  22
<211>  14
<212>  PRT
<213>  ˹

<400>  22

Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly 
1               5                   10                  


<210>  23
<211>  32
<212>  PRT
<213>  ˹

<400>  23

Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr Met Glu 
1               5                   10                  15      


Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  24
<211>  11
<212>  PRT
<213>  ˹

<400>  24

Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
1               5                   10      


<210>  25
<211>  642
<212>  DNA
<213>  ˹

<400>  25
gatatccagc tgacccagag cccctccttt ctgtccgcct ccgtgggcga cagggtgacc     60

atcacctgca gggccagctc cagcgtgagc aacatccact ggtatcaaca gaagcctggc    120

aaggccccca agccctggat ctacgccacc tccaacctgg ccagcggcgt gcctagcagg    180

ttcagcggtt ctggctccgg caccgagttc accctgacca tctcctccct gcagcccgag    240

gacttcgcca cctactactg ccagcagtgg tccagcaacc ccctgacctt tggccagggc    300

accaagctgg agatcaagag gactgtggct gcaccatctg tcttcatctt cccgccatct    360

gatgagcagt tgaaatctgg aactgcctct gttgtgtgcc tgctgaataa cttctatccc    420

agagaggcca aagtacagtg gaaggtggat aacgccctcc aatcgggtaa ctcccaggag    480

agtgtcacag agcaggacag caaggacagc acctacagcc tcagcagcac cctgacgctg    540

agcaaagcag actacgagaa acacaaagtc tacgcctgcg aagtcaccca tcagggcctg    600

agctcgcccg tcacaaagag cttcaacagg ggagagtgtt aa                       642


<210>  26
<211>  213
<212>  PRT
<213>  ˹

<400>  26

Asp Ile Gln Leu Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Ser Ser Val Ser Asn Ile 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Pro Trp Ile Tyr 
        35                  40                  45              


Ala Thr Ser Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
65                  70                  75                  80  


Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Leu Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala Pro 
            100                 105                 110         


Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr 
        115                 120                 125             


Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys 
    130                 135                 140                 


Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu 
145                 150                 155                 160 


Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser 
                165                 170                 175     


Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala 
            180                 185                 190         


Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe 
        195                 200                 205             


Asn Arg Gly Glu Cys 
    210             


<210>  27
<211>  30
<212>  DNA
<213>  ˹

<400>  27
agggccagct ccagcgtgag caacatccac                                      30


<210>  28
<211>  21
<212>  DNA
<213>  ˹

<400>  28
gccacctcca acctggccag c                                               21


<210>  29
<211>  27
<212>  DNA
<213>  ˹

<400>  29
cagcagtggt ccagcaaccc cctgacc                                         27


<210>  30
<211>  69
<212>  DNA
<213>  ˹

<400>  30
gatatccagc tgacccagag cccctccttt ctgtccgcct ccgtgggcga cagggtgacc     60

atcacctgc                                                             69


<210>  31
<211>  45
<212>  DNA
<213>  ˹

<400>  31
tggtatcaac agaagcctgg caaggccccc aagccctgga tctac                     45


<210>  32
<211>  96
<212>  DNA
<213>  ˹

<400>  32
ggcgtgccta gcaggttcag cggttctggc tccggcaccg agttcaccct gaccatctcc     60

tccctgcagc ccgaggactt cgccacctac tactgc                               96


<210>  33
<211>  33
<212>  DNA
<213>  ˹

<400>  33
tttggccagg gcaccaagct ggagatcaag agg                                  33


<210>  34
<211>  10
<212>  PRT
<213>  ˹

<400>  34

Arg Ala Ser Ser Ser Val Ser Asn Ile His 
1               5                   10  


<210>  35
<211>  7
<212>  PRT
<213>  ˹

<400>  35

Ala Thr Ser Asn Leu Ala Ser 
1               5           


<210>  36
<211>  9
<212>  PRT
<213>  ˹

<400>  36

Gln Gln Trp Ser Ser Asn Pro Leu Thr 
1               5                   


<210>  37
<211>  23
<212>  PRT
<213>  ˹

<400>  37

Asp Ile Gln Leu Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys 
            20              


<210>  38
<211>  15
<212>  PRT
<213>  ˹

<400>  38

Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Pro Trp Ile Tyr 
1               5                   10                  15  


<210>  39
<211>  32
<212>  PRT
<213>  ˹

<400>  39

Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr 
1               5                   10                  15      


Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 
            20                  25                  30          


<210>  40
<211>  11
<212>  PRT
<213>  ˹

<400>  40

Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg 
1               5                   10      


<210>  41
<211>  642
<212>  DNA
<213>  ˹

<400>  41
gatatccagc tgacccagag cccctccttt ctgtccgcct ccgtgggcga cagggtgacc     60

atcacctgca gggccagctc caagacgggg aacatccact ggtatcaaca gaagcctggc    120

aaggccccca agccctggat ctacgccacc tccaacctgg ccagcggcgt gcctagcagg    180

ttcagcggtt ctggctccgg caccgagttc accctgacca tctcctccct gcagcccgag    240

gacttcgcca cctactactg ccagcagtgg tccagcaacc ccctgacctt tggccagggc    300

accaagctgg agatcaagag gactgtggct gcaccatctg tcttcatctt cccgccatct    360

gatgagcagt tgaaatctgg aactgcctct gttgtgtgcc tgctgaataa cttctatccc    420

agagaggcca aagtacagtg gaaggtggat aacgccctcc aatcgggtaa ctcccaggag    480

agtgtcacag agcaggacag caaggacagc acctacagcc tcagcagcac cctgacgctg    540

agcaaagcag actacgagaa acacaaagtc tacgcctgcg aagtcaccca tcagggcctg    600

agctcgcccg tcacaaagag cttcaacagg ggagagtgtt aa                       642


<210>  42
<211>  213
<212>  PRT
<213>  ˹

<400>  42

Asp Ile Gln Leu Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Ser Lys Thr Gly Asn Ile 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Pro Trp Ile Tyr 
        35                  40                  45              


Ala Thr Ser Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
65                  70                  75                  80  


Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Leu Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala Pro 
            100                 105                 110         


Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr 
        115                 120                 125             


Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys 
    130                 135                 140                 


Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu 
145                 150                 155                 160 


Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser 
                165                 170                 175     


Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala 
            180                 185                 190         


Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe 
        195                 200                 205             


Asn Arg Gly Glu Cys 
    210             


<210>  43
<211>  321
<212>  DNA
<213>  ˹

<400>  43
gatatccagc tgacccagag cccctccttt ctgtccgcct ccgtgggcga cagggtgacc     60

atcacctgca gggccagctc caagacgggg aacatccact ggtatcaaca gaagcctggc    120

aaggccccca agccctggat ctacgccacc tccaacctgg ccagcggcgt gcctagcagg    180

ttcagcggtt ctggctccgg caccgagttc accctgacca tctcctccct gcagcccgag    240

gacttcgcca cctactactg ccagcagtgg tccagcaacc ccctgacctt tggccagggc    300

accaagctgg agatcaagag g                                              321


<210>  44
<211>  30
<212>  DNA
<213>  ˹

<400>  44
agggccagct ccaagacggg gaacatccac                                      30


<210>  45
<211>  107
<212>  PRT
<213>  ˹

<400>  45

Asp Ile Gln Leu Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Ser Lys Thr Gly Asn Ile 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Pro Trp Ile Tyr 
        35                  40                  45              


Ala Thr Ser Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
65                  70                  75                  80  


Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Leu Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105         


<210>  46
<211>  10
<212>  PRT
<213>  ˹

<400>  46

Arg Ala Ser Ser Lys Thr Gly Asn Ile His 
1               5                   10  


<210>  47
<211>  642
<212>  DNA
<213>  ˹

<400>  47
gatatccagc tgacccagag cccctccttt ctgtccgcct ccgtgggcga cagggtgacc     60

atcacctgca gggccagctc cggcgcgtcc aacatccact ggtatcaaca gaagcctggc    120

aaggccccca agccctggat ctacgccacc tccaacctgg ccagcggcgt gcctagcagg    180

ttcagcggtt ctggctccgg caccgagttc accctgacca tctcctccct gcagcccgag    240

gacttcgcca cctactactg ccagcagtgg tccagcaacc ccctgacctt tggccagggc    300

accaagctgg agatcaagag gactgtggct gcaccatctg tcttcatctt cccgccatct    360

gatgagcagt tgaaatctgg aactgcctct gttgtgtgcc tgctgaataa cttctatccc    420

agagaggcca aagtacagtg gaaggtggat aacgccctcc aatcgggtaa ctcccaggag    480

agtgtcacag agcaggacag caaggacagc acctacagcc tcagcagcac cctgacgctg    540

agcaaagcag actacgagaa acacaaagtc tacgcctgcg aagtcaccca tcagggcctg    600

agctcgcccg tcacaaagag cttcaacagg ggagagtgtt aa                       642


<210>  48
<211>  213
<212>  PRT
<213>  ˹

<400>  48

Asp Ile Gln Leu Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Ser Gly Ala Ser Asn Ile 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Pro Trp Ile Tyr 
        35                  40                  45              


Ala Thr Ser Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
65                  70                  75                  80  


Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Leu Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala Pro 
            100                 105                 110         


Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr 
        115                 120                 125             


Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys 
    130                 135                 140                 


Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu 
145                 150                 155                 160 


Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser 
                165                 170                 175     


Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala 
            180                 185                 190         


Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe 
        195                 200                 205             


Asn Arg Gly Glu Cys 
    210             


<210>  49
<211>  321
<212>  DNA
<213>  ˹

<400>  49
gatatccagc tgacccagag cccctccttt ctgtccgcct ccgtgggcga cagggtgacc     60

atcacctgca gggccagctc cggcgcgtcc aacatccact ggtatcaaca gaagcctggc    120

aaggccccca agccctggat ctacgccacc tccaacctgg ccagcggcgt gcctagcagg    180

ttcagcggtt ctggctccgg caccgagttc accctgacca tctcctccct gcagcccgag    240

gacttcgcca cctactactg ccagcagtgg tccagcaacc ccctgacctt tggccagggc    300

accaagctgg agatcaagag g                                              321


<210>  50
<211>  30
<212>  DNA
<213>  ˹

<400>  50
agggccagct ccggcgcgtc caacatccac                                      30


<210>  51
<211>  107
<212>  PRT
<213>  ˹

<400>  51

Asp Ile Gln Leu Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Ser Gly Ala Ser Asn Ile 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Pro Trp Ile Tyr 
        35                  40                  45              


Ala Thr Ser Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
65                  70                  75                  80  


Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Leu Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105         


<210>  52
<211>  10
<212>  PRT
<213>  ˹

<400>  52

Arg Ala Ser Ser Gly Ala Ser Asn Ile His 
1               5                   10  


<210>  53
<211>  97
<212>  DNA
<213>  ˹

<400>  53
ggggtaccgc cgccaccatg gagacagaca cactcctgct atgggtactg ctgctctggg     60

ttccaggttc cactggtgag gtgcagctgg tgcagag                              97


<210>  54
<211>  34
<212>  DNA
<213>  ˹

<400>  54
ggctctagat tatcactttc caggggacag tgac                                 34


<210>  55
<211>  97
<212>  DNA
<213>  ˹

<400>  55
ggggtaccgc cgccaccatg gagacagaca cactcctgct atgggtactg ctgctctggg     60

ttccaggttc cactggtgat atccagctga cccagag                              97


<210>  56
<211>  32
<212>  DNA
<213>  ˹

<400>  56
ggctctagat taacactctc ccctgttgaa gc                                   32


