                         SEQUENCE LISTING

<110>  Evgin, Laura
 
<120>  Pseudotyped Oncolytic Rhabdoviruses and Their Use in Combination Therapy

<130>  PAT 104044W90

<150>  US 62/338,940
<151>  2016-05-19

<160>  4     

<170>  PatentIn version 3.5

<210>  1
<211>  1492
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon-optimized Junin glycoprotein coding sequence

<400>  1
ggtacccagt tatatttgtt acaacaatgg gacaattcat ctccttcatg caggagatac       60

ctactttcct ccaagaggct ctcaatatcg ctctggtggc ggtttcactg atcgctatca      120

taaagggcat tgtgaacttg tacaaatcag gcctgttcca attctttgtg ttcctggctc      180

ttgcagggag atcttgtaca gaagaggctt ttaaaatcgg cctccacact gagtttcaga      240

ccgtgagttt ctcaatggtc ggcctgtttt caaataatcc ccatgacctg cccctgttgt      300

gtaccctgaa caagagtcac ctgtacatca agggcggaaa cgcatcattc atgatctcct      360

ttgacgatat tgaagtgctg ctgcctcaat acgatgtgat aatacagcac ccagccgaca      420

tgtcctggtg cagcaagtcc gatgaccaaa tttggttgtc ccagtggttt atgaatgcag      480

tcggacatga ttggcacttg gacccaccct tcctttgccg caatagaact aagaccgagg      540

gtttcatttt tcaggtcaac acaagcaaga ctggggtcaa cgaaaactat gcaaaaaagt      600

tcaagacagg tatgcatcac ctctaccggg agtaccctga ttcttgcctg aacgggaagt      660

tgtgcctgat gaaggcccag ccaacgtcct ggcctctgca gtgccctttg gaccatgtga      720

acactttgca ctttctcact agaggcaaaa acatccagct ccctaggcga tcccttaagg      780

cgttcttttc ttggagtctg acggattctt ccggaaagga cacccctggg ggctactgtc      840

tcgaagaatg gatgctggta gctgcaaaga tgaaatgttt tgggaacact gccgtcgcga      900

aatgcaacct gaaccatgat tctgaatttt gcgatatgct ccgacttttc gactataata      960

agaatgctat caagacactg aacgatgaaa ctaagaaaca ggtgaatctc atgggacaga     1020

ccattaatgc tctgatcagt gacaatctgc tgatgaagaa taaaatccga gagctgatgt     1080

cagtgcccta ttgtaattat acaaaatttt ggtacgtgaa tcacacactg tccggccagc     1140

actctctgcc gaggtgctgg ctgattaaga ataatagcta cttgaacatc agcgacttca     1200

gaaacgactg gattctcgag tccgattttc tgatcagcga aatgctcagt aaagagtatt     1260

cagacagaca gggcaagaca ccccttactc tcgttgatat ttgtttttgg agtacagttt     1320

tttttacggc ctccctgttc ctccatctgg tcggtattcc tacccaccga catatccgcg     1380

gcgaggcatg tccactgcct catcgcctca attcactggg aggctgtcga tgtggaaagt     1440

atccgaatct caaaaaacct accgtctggc gcagaagaca ttaggcggcc gc             1492


<210>  2
<211>  485
<212>  PRT
<213>  Arenavirus - Junin

<400>  2

Met Gly Gln Phe Ile Ser Phe Met Gln Glu Ile Pro Thr Phe Leu Gln 
1               5                   10                  15      


Glu Ala Leu Asn Ile Ala Leu Val Ala Val Ser Leu Ile Ala Ile Ile 
            20                  25                  30          


Lys Gly Ile Val Asn Leu Tyr Lys Ser Gly Leu Phe Gln Phe Phe Val 
        35                  40                  45              


Phe Leu Ala Leu Ala Gly Arg Ser Cys Thr Glu Glu Ala Phe Lys Ile 
    50                  55                  60                  


Gly Leu His Thr Glu Phe Gln Thr Val Ser Phe Ser Met Val Gly Leu 
65                  70                  75                  80  


Phe Ser Asn Asn Pro His Asp Leu Pro Leu Leu Cys Thr Leu Asn Lys 
                85                  90                  95      


Ser His Leu Tyr Ile Lys Gly Gly Asn Ala Ser Phe Met Ile Ser Phe 
            100                 105                 110         


Asp Asp Ile Glu Val Leu Leu Pro Gln Tyr Asp Val Ile Ile Gln His 
        115                 120                 125             


Pro Ala Asp Met Ser Trp Cys Ser Lys Ser Asp Asp Gln Ile Trp Leu 
    130                 135                 140                 


Ser Gln Trp Phe Met Asn Ala Val Gly His Asp Trp His Leu Asp Pro 
145                 150                 155                 160 


Pro Phe Leu Cys Arg Asn Arg Thr Lys Thr Glu Gly Phe Ile Phe Gln 
                165                 170                 175     


Val Asn Thr Ser Lys Thr Gly Val Asn Glu Asn Tyr Ala Lys Lys Phe 
            180                 185                 190         


Lys Thr Gly Met His His Leu Tyr Arg Glu Tyr Pro Asp Ser Cys Leu 
        195                 200                 205             


Asn Gly Lys Leu Cys Leu Met Lys Ala Gln Pro Thr Ser Trp Pro Leu 
    210                 215                 220                 


Gln Cys Pro Leu Asp His Val Asn Thr Leu His Phe Leu Thr Arg Gly 
225                 230                 235                 240 


Lys Asn Ile Gln Leu Pro Arg Arg Ser Leu Lys Ala Phe Phe Ser Trp 
                245                 250                 255     


Ser Leu Thr Asp Ser Ser Gly Lys Asp Thr Pro Gly Gly Tyr Cys Leu 
            260                 265                 270         


Glu Glu Trp Met Leu Val Ala Ala Lys Met Lys Cys Phe Gly Asn Thr 
        275                 280                 285             


Ala Val Ala Lys Cys Asn Leu Asn His Asp Ser Glu Phe Cys Asp Met 
    290                 295                 300                 


Leu Arg Leu Phe Asp Tyr Asn Lys Asn Ala Ile Lys Thr Leu Asn Asp 
305                 310                 315                 320 


Glu Thr Lys Lys Gln Val Asn Leu Met Gly Gln Thr Ile Asn Ala Leu 
                325                 330                 335     


Ile Ser Asp Asn Leu Leu Met Lys Asn Lys Ile Arg Glu Leu Met Ser 
            340                 345                 350         


Val Pro Tyr Cys Asn Tyr Thr Lys Phe Trp Tyr Val Asn His Thr Leu 
        355                 360                 365             


Ser Gly Gln His Ser Leu Pro Arg Cys Trp Leu Ile Lys Asn Asn Ser 
    370                 375                 380                 


Tyr Leu Asn Ile Ser Asp Phe Arg Asn Asp Trp Ile Leu Glu Ser Asp 
385                 390                 395                 400 


Phe Leu Ile Ser Glu Met Leu Ser Lys Glu Tyr Ser Asp Arg Gln Gly 
                405                 410                 415     


Lys Thr Pro Leu Thr Leu Val Asp Ile Cys Phe Trp Ser Thr Val Phe 
            420                 425                 430         


Phe Thr Ala Ser Leu Phe Leu His Leu Val Gly Ile Pro Thr His Arg 
        435                 440                 445             


His Ile Arg Gly Glu Ala Cys Pro Leu Pro His Arg Leu Asn Ser Leu 
    450                 455                 460                 


Gly Gly Cys Arg Cys Gly Lys Tyr Pro Asn Leu Lys Lys Pro Thr Val 
465                 470                 475                 480 


Trp Arg Arg Arg His 
                485 


<210>  3
<211>  1507
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon-optimized Lassa glycoprotein coding sequence

<400>  3
ggtacccagt tatatttgtt acaacaatgg gacaaatcat cacgtttttc caggaagtgc       60

cccacgtcat agaggaggta atgaatatag tgctcattgc cctcagtttg ctggcgatcc      120

tgaaagggat ctacaacgtg gcgacttgtg gtctgtttgg cttggtgtct ttcctgctgt      180

tgtgcggtcg aagctgcagt accacctata agggagtcta cgagctgcag acactggaac      240

tggacatggc tagcttgaac atgactatgc ctctctcctg cacaaagaat aacagtcacc      300

attacataat ggtggggaat gaaactggtt tggaactcac acttaccaac acatccatca      360

taaatcacaa gttttgtaac ctcagtgacg cccacaaaaa aaacttgtat gatcacgctc      420

tcatgtccat aatcagcact tttcacctgt ctatccctaa cttcaatcag tacgaggcta      480

tgtcttgcga ctttaacggg ggcaaaatca gcgtgcaata caatctgagc cacgcatatg      540

ccgtcgacgc cgccaaccac tgcggaacta tcgctaacgg cgtcctgcag acattcatgc      600

ggatggcttg gggcggctcc tatatcgctc tggatagcgg aaagggcagt tgggactgta      660

ttatgacctc ataccagtac cttattatcc agaacaccac ctgggaggat cactgtcaat      720

tttcccggcc gtccccaatc ggctatctgg gcctcctgag ccaaagaact cgggacattt      780

acatatctcg gcgactcctc gggacattca catggaccct gtccgactct gaagggaatg      840

aaacgccagg cgggtattgc ctgacccgat ggatgctgat cgaagccgag ctcaagtgct      900

ttggaaatac cgcagtcgcc aagtgtaatg aaaagcatga tgaagaattt tgcgatatgc      960

tgcggctgtt cgatttcaat aaacaggcca ttcgacggct gaaaaccgag gcccaaatga     1020

gtatccagct gattaacaag gccgttaatg ccctgattaa tgaccagctc attatgaaaa     1080

atcacctgcg ggatatcatg ggcattcctt actgtaacta ttccaagtat tggtatctga     1140

accacaccgt gactggcaaa acgtcactgc caaggtgctg gctggtctcc aatggaagct     1200

acctgaacga gacccatttt tccgatgata tcgagcagca ggccgataat atgattaccg     1260

aactgttgca gaaagaatac atggaccgcc agggcaaaac tccacttggg ttggtcgacc     1320

tgtttgtgtt ctctaccagc ttctacttga ttagcatttt cctgcacctg gtgcgcatcc     1380

ccacgcacag acatgtcatc ggtaagccat gccctaagcc gcatagactc aaccatatgg     1440

ggatttgctc ctgtggtctc tataaacacc ccggcgtgcc tgtcaaatgg aagaggtgag     1500

cggccgc                                                               1507


<210>  4
<211>  490
<212>  PRT
<213>  Arenavirus - Lassa

<400>  4

Met Gly Gln Ile Ile Thr Phe Phe Gln Glu Val Pro His Val Ile Glu 
1               5                   10                  15      


Glu Val Met Asn Ile Val Leu Ile Ala Leu Ser Leu Leu Ala Ile Leu 
            20                  25                  30          


Lys Gly Ile Tyr Asn Val Ala Thr Cys Gly Leu Phe Gly Leu Val Ser 
        35                  40                  45              


Phe Leu Leu Leu Cys Gly Arg Ser Cys Ser Thr Thr Tyr Lys Gly Val 
    50                  55                  60                  


Tyr Glu Leu Gln Thr Leu Glu Leu Asp Met Ala Ser Leu Asn Met Thr 
65                  70                  75                  80  


Met Pro Leu Ser Cys Thr Lys Asn Asn Ser His His Tyr Ile Met Val 
                85                  90                  95      


Gly Asn Glu Thr Gly Leu Glu Leu Thr Leu Thr Asn Thr Ser Ile Ile 
            100                 105                 110         


Asn His Lys Phe Cys Asn Leu Ser Asp Ala His Lys Lys Asn Leu Tyr 
        115                 120                 125             


Asp His Ala Leu Met Ser Ile Ile Ser Thr Phe His Leu Ser Ile Pro 
    130                 135                 140                 


Asn Phe Asn Gln Tyr Glu Ala Met Ser Cys Asp Phe Asn Gly Gly Lys 
145                 150                 155                 160 


Ile Ser Val Gln Tyr Asn Leu Ser His Ala Tyr Ala Val Asp Ala Ala 
                165                 170                 175     


Asn His Cys Gly Thr Ile Ala Asn Gly Val Leu Gln Thr Phe Met Arg 
            180                 185                 190         


Met Ala Trp Gly Gly Ser Tyr Ile Ala Leu Asp Ser Gly Lys Gly Ser 
        195                 200                 205             


Trp Asp Cys Ile Met Thr Ser Tyr Gln Tyr Leu Ile Ile Gln Asn Thr 
    210                 215                 220                 


Thr Trp Glu Asp His Cys Gln Phe Ser Arg Pro Ser Pro Ile Gly Tyr 
225                 230                 235                 240 


Leu Gly Leu Leu Ser Gln Arg Thr Arg Asp Ile Tyr Ile Ser Arg Arg 
                245                 250                 255     


Leu Leu Gly Thr Phe Thr Trp Thr Leu Ser Asp Ser Glu Gly Asn Glu 
            260                 265                 270         


Thr Pro Gly Gly Tyr Cys Leu Thr Arg Trp Met Leu Ile Glu Ala Glu 
        275                 280                 285             


Leu Lys Cys Phe Gly Asn Thr Ala Val Ala Lys Cys Asn Glu Lys His 
    290                 295                 300                 


Asp Glu Glu Phe Cys Asp Met Leu Arg Leu Phe Asp Phe Asn Lys Gln 
305                 310                 315                 320 


Ala Ile Arg Arg Leu Lys Thr Glu Ala Gln Met Ser Ile Gln Leu Ile 
                325                 330                 335     


Asn Lys Ala Val Asn Ala Leu Ile Asn Asp Gln Leu Ile Met Lys Asn 
            340                 345                 350         


His Leu Arg Asp Ile Met Gly Ile Pro Tyr Cys Asn Tyr Ser Lys Tyr 
        355                 360                 365             


Trp Tyr Leu Asn His Thr Val Thr Gly Lys Thr Ser Leu Pro Arg Cys 
    370                 375                 380                 


Trp Leu Val Ser Asn Gly Ser Tyr Leu Asn Glu Thr His Phe Ser Asp 
385                 390                 395                 400 


Asp Ile Glu Gln Gln Ala Asp Asn Met Ile Thr Glu Leu Leu Gln Lys 
                405                 410                 415     


Glu Tyr Met Asp Arg Gln Gly Lys Thr Pro Leu Gly Leu Val Asp Leu 
            420                 425                 430         


Phe Val Phe Ser Thr Ser Phe Tyr Leu Ile Ser Ile Phe Leu His Leu 
        435                 440                 445             


Val Arg Ile Pro Thr His Arg His Val Ile Gly Lys Pro Cys Pro Lys 
    450                 455                 460                 


Pro His Arg Leu Asn His Met Gly Ile Cys Ser Cys Gly Leu Tyr Lys 
465                 470                 475                 480 


His Pro Gly Val Pro Val Lys Trp Lys Arg 
                485                 490 


