                               SEQUENCE LISTING

<110> PRESIDENT AND FELLOWS OF HARVARD COLLEGE
 
<120> AAV SPLIT CAS9 GENOME EDITING AND TRANSCRIPTIONAL REGULATION

<130> 010498.00959/WO

<140> PCT/US2017/032362
<141> 2017-05-12

<150> 62/335,271
<151> 2016-05-12

<160> 50    

<170> PatentIn version 3.5

<210> 1
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 1
Cys Ala Ser Ser Leu Asp Arg Gly Gln Asp Thr Gln Tyr Phe 
1               5                   10                  


<210> 2
<211> 1368
<212> PRT
<213> Streptococcus pyogenes

<400> 2
Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
    530                 535                 540                 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
625                 630                 635                 640 


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
705                 710                 715                 720 


His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 
    770                 775                 780                 


Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 
            820                 825                 830         


Leu Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Leu Lys 
        835                 840                 845             


Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 
865                 870                 875                 880 


Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 
    930                 935                 940                 


Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser 
945                 950                 955                 960 


Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Val Gly Thr Ala Leu Ile Lys Lys  Tyr Pro Lys Leu Glu  Ser Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Lys Val  Tyr Asp Val Arg Lys  Met Ile Ala 
    1010                 1015                 1020             


Lys Ser  Glu Gln Glu Ile Gly  Lys Ala Thr Ala Lys  Tyr Phe Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Thr Glu Ile  Thr Leu Ala 
    1040                 1045                 1050             


Asn Gly  Glu Ile Arg Lys Arg  Pro Leu Ile Glu Thr  Asn Gly Glu 
    1055                 1060                 1065             


Thr Gly  Glu Ile Val Trp Asp  Lys Gly Arg Asp Phe  Ala Thr Val 
    1070                 1075                 1080             


Arg Lys  Val Leu Ser Met Pro  Gln Val Asn Ile Val  Lys Lys Thr 
    1085                 1090                 1095             


Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu Ser Ile  Leu Pro Lys 
    1100                 1105                 1110             


Arg Asn  Ser Asp Lys Leu Ile  Ala Arg Lys Lys Asp  Trp Asp Pro 
    1115                 1120                 1125             


Lys Lys  Tyr Gly Gly Phe Asp  Ser Pro Thr Val Ala  Tyr Ser Val 
    1130                 1135                 1140             


Leu Val  Val Ala Lys Val Glu  Lys Gly Lys Ser Lys  Lys Leu Lys 
    1145                 1150                 1155             


Ser Val  Lys Glu Leu Leu Gly  Ile Thr Ile Met Glu  Arg Ser Ser 
    1160                 1165                 1170             


Phe Glu  Lys Asn Pro Ile Asp  Phe Leu Glu Ala Lys  Gly Tyr Lys 
    1175                 1180                 1185             


Glu Val  Lys Lys Asp Leu Ile  Ile Lys Leu Pro Lys  Tyr Ser Leu 
    1190                 1195                 1200             


Phe Glu  Leu Glu Asn Gly Arg  Lys Arg Met Leu Ala  Ser Ala Gly 
    1205                 1210                 1215             


Glu Leu  Gln Lys Gly Asn Glu  Leu Ala Leu Pro Ser  Lys Tyr Val 
    1220                 1225                 1230             


Asn Phe  Leu Tyr Leu Ala Ser  His Tyr Glu Lys Leu  Lys Gly Ser 
    1235                 1240                 1245             


Pro Glu  Asp Asn Glu Gln Lys  Gln Leu Phe Val Glu  Gln His Lys 
    1250                 1255                 1260             


His Tyr  Leu Asp Glu Ile Ile  Glu Gln Ile Ser Glu  Phe Ser Lys 
    1265                 1270                 1275             


Arg Val  Ile Leu Ala Asp Ala  Asn Leu Asp Lys Val  Leu Ser Ala 
    1280                 1285                 1290             


Tyr Asn  Lys His Arg Asp Lys  Pro Ile Arg Glu Gln  Ala Glu Asn 
    1295                 1300                 1305             


Ile Ile  His Leu Phe Thr Leu  Thr Asn Leu Gly Ala  Pro Ala Ala 
    1310                 1315                 1320             


Phe Lys  Tyr Phe Asp Thr Thr  Ile Asp Arg Lys Arg  Tyr Thr Ser 
    1325                 1330                 1335             


Thr Lys  Glu Val Leu Asp Ala  Thr Leu Ile His Gln  Ser Ile Thr 
    1340                 1345                 1350             


Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser Gln Leu  Gly Gly Asp 
    1355                 1360                 1365             


<210> 3
<211> 83
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 3
gttttagagc tagaaatagc aagttaaaat aaggctagtc cgttatcaac ttgaaaaagt       60

ggcaccgagt cggtgctttt ttt                                               83


<210> 4
<211> 9
<212> PRT
<213> Streptococcus pyogenes

<400> 4
Ile Thr Gly Leu Tyr Glu Thr Arg Ile 
1               5                   


<210> 5
<211> 12
<212> PRT
<213> Streptococcus pyogenes

<400> 5
Ile Val Asp Glu Val Ala Tyr His Glu Lys Tyr Pro 
1               5                   10          


<210> 6
<211> 10
<212> PRT
<213> Streptococcus pyogenes

<400> 6
Trp Asp Pro Lys Lys Tyr Gly Gly Phe Asp 
1               5                   10  


<210> 7
<211> 19
<212> PRT
<213> Adeno-associated virus

<400> 7
Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asp Gly Ser Gln 
1               5                   10                  15      


Ala Val Gly 
            


<210> 8
<211> 10
<212> PRT
<213> Adeno-associated virus

<400> 8
Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr 
1               5                   10  


<210> 9
<211> 12
<212> PRT
<213> Adeno-associated virus

<400> 9
Thr Gln Asn Asn Asn Ser Glu Phe Ala Trp Pro Gly 
1               5                   10          


<210> 10
<211> 40
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 10
gggccatgtg gacatccatg aggtgagaca gtgccagcgt                             40


<210> 11
<211> 38
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 11
ggcctgaagc cactacagct gctggagatc aaggctcg                               38


<210> 12
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 12
ggccctagca tctaagttct cgcaggc                                           27


<210> 13
<211> 35
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 13
ggtcattcca tctcagctgt gacagcagcg cagaa                                  35


<210> 14
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 14
gtcaagccca aagtctctcc gggacctctt                                        30


<210> 15
<211> 29
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 15
ggaatcccgg tgctgccgct accccctca                                         29


<210> 16
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 16
gctagagaat aggaacttct t                                                 21


<210> 17
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 17
gaaagaattg atttgatacc g                                                 21


<210> 18
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 18
gatccccatc aagctgatc                                                    19


<210> 19
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 19
ggtatgctat acgaagttat t                                                 21


<210> 20
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 20
gctcgagata agacc                                                        15


<210> 21
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 21
gctaaagtca tccgc                                                        15


<210> 22
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 22
ggttcttatt tgcgt                                                        15


<210> 23
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 23
ggaaatcaaa gcggc                                                        15


<210> 24
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 24
gaaggagttc ctcgg                                                        15


<210> 25
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 25
gaggaggtcc acttc                                                        15


<210> 26
<211> 54
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer


<220>
<221> modified_base
<222> (29)..(34)
<223> a, c, t, g, unknown or other

<400> 26
ctttccctac acgacgctct tccgatctnn nnnnctggag tgttagagtg ggcg             54


<210> 27
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 27
ggagttcaga cgtgtgctct tccgatctga ctgccccatg gaaagaca                    48


<210> 28
<211> 58
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer


<220>
<221> modified_base
<222> (29)..(34)
<223> a, c, t, g, unknown or other

<400> 28
ctttccctac acgacgctct tccgatctnn nnnngggcca tgaaaggaaa aatgaagt         58


<210> 29
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 29
ggagttcaga cgtgtgctct tccgatctgc ctctggggtt tgcttggt                    48


<210> 30
<211> 67
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer


<220>
<221> modified_base
<222> (29)..(34)
<223> a, c, t, g, unknown or other

<400> 30
ctttccctac acgacgctct tccgatctnn nnnngagata taagctgaat aaggccaatg       60

acatact                                                                 67


<210> 31
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 31
ggagttcaga cgtgtgctct tccgatctct actgctcttt cctgccga                    48


<210> 32
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 32
gcctactcgc tgctgcccat t                                                 21


<210> 33
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 33
cctggagacc cccaaaagct c                                                 21


<210> 34
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      probe

<400> 34
agatcttccc acttcaggt                                                    19


<210> 35
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 35
ggaaccccta gtgatggagt t                                                 21


<210> 36
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 36
cggcctcagt gagcga                                                       16


<210> 37
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      probe

<400> 37
cactccctct ctgcgcgctc g                                                 21


<210> 38
<211> 831
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 38
Met Ala Pro Lys Lys Lys Arg Lys Val Gly Ile His Gly Val Pro Ala 
1               5                   10                  15      


Ala Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
            20                  25                  30          


Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe 
        35                  40                  45              


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
    50                  55                  60                  


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
65                  70                  75                  80  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
                85                  90                  95      


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
            100                 105                 110         


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
        115                 120                 125             


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
    130                 135                 140                 


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
145                 150                 155                 160 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
                165                 170                 175     


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
            180                 185                 190         


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
        195                 200                 205             


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 
    210                 215                 220                 


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
225                 230                 235                 240 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
                245                 250                 255     


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
            260                 265                 270         


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
        275                 280                 285             


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
    290                 295                 300                 


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
305                 310                 315                 320 


Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
                325                 330                 335     


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
            340                 345                 350         


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
        355                 360                 365             


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
    370                 375                 380                 


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
385                 390                 395                 400 


Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg 
                405                 410                 415     


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
            420                 425                 430         


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
        435                 440                 445             


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
    450                 455                 460                 


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
465                 470                 475                 480 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
                485                 490                 495     


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
            500                 505                 510         


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
        515                 520                 525             


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
    530                 535                 540                 


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
545                 550                 555                 560 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
                565                 570                 575     


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
            580                 585                 590         


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
        595                 600                 605             


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
    610                 615                 620                 


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
625                 630                 635                 640 


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
                645                 650                 655     


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
            660                 665                 670         


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
        675                 680                 685             


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
    690                 695                 700                 


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
705                 710                 715                 720 


Lys Glu Asp Ile Gln Lys Ala Gln Val Cys Leu Ala Gly Asp Thr Leu 
                725                 730                 735     


Ile Thr Leu Ala Asp Gly Arg Arg Val Pro Ile Arg Glu Leu Val Ser 
            740                 745                 750         


Gln Gln Asn Phe Ser Val Trp Ala Leu Asn Pro Gln Thr Tyr Arg Leu 
        755                 760                 765             


Glu Arg Ala Arg Val Ser Arg Ala Phe Cys Thr Gly Ile Lys Pro Val 
    770                 775                 780                 


Tyr Arg Leu Thr Thr Arg Leu Gly Arg Ser Ile Arg Ala Thr Ala Asn 
785                 790                 795                 800 


His Arg Phe Leu Thr Pro Gln Gly Trp Lys Arg Val Asp Glu Leu Gln 
                805                 810                 815     


Pro Gly Asp Tyr Leu Ala Leu Pro Arg Arg Ile Pro Thr Ala Ser 
            820                 825                 830     


<210> 39
<211> 2496
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 39
atggccccaa agaagaagcg gaaggtcggt atccacggag tcccagcagc cgacaagaag       60

tactccattg ggctcgatat cggcacaaac agcgtcggct gggccgtcat tacggacgag      120

tacaaggtgc cgagcaaaaa attcaaagtt ctgggcaata ccgatcgcca cagcataaag      180

aagaacctca ttggcgccct cctgttcgac tccggggaaa cggccgaagc cacgcggctc      240

aaaagaacag cacggcgcag atatacccgc agaaagaatc ggatctgcta cctgcaggag      300

atctttagta atgagatggc taaggtggat gactctttct tccataggct ggaggagtcc      360

tttttggtgg aggaggataa aaagcacgag cgccacccaa tctttggcaa tatcgtggac      420

gaggtggcgt accatgaaaa gtacccaacc atatatcatc tgaggaagaa gcttgtagac      480

agtactgata aggctgactt gcggttgatc tatctcgcgc tggcgcatat gatcaaattt      540

cggggacact tcctcatcga gggggacctg aacccagaca acagcgatgt cgacaaactc      600

tttatccaac tggttcagac ttacaatcag cttttcgaag agaacccgat caacgcatcc      660

ggagttgacg ccaaagcaat cctgagcgct aggctgtcca aatcccggcg gctcgaaaac      720

ctcatcgcac agctccctgg ggagaagaag aacggcctgt ttggtaatct tatcgccctg      780

tcactcgggc tgacccccaa ctttaaatct aacttcgacc tggccgaaga tgccaagctt      840

caactgagca aagacaccta cgatgatgat ctcgacaatc tgctggccca gatcggcgac      900

cagtacgcag accttttttt ggcggcaaag aacctgtcag acgccattct gctgagtgat      960

attctgcgag tgaacacgga gatcaccaaa gctccgctga gcgctagtat gatcaagcgc     1020

tatgatgagc accaccaaga cttgactttg ctgaaggccc ttgtcagaca gcaactgcct     1080

gagaagtaca aggaaatttt cttcgatcag tctaaaaatg gctacgccgg atacattgac     1140

ggcggagcaa gccaggagga attttacaaa tttattaagc ccatcttgga aaaaatggac     1200

ggcaccgagg agctgctggt aaagcttaac agagaagatc tgttgcgcaa acagcgcact     1260

ttcgacaatg gaagcatccc ccaccagatt cacctgggcg aactgcacgc tatcctcagg     1320

cggcaagagg atttctaccc ctttttgaaa gataacaggg aaaagattga gaaaatcctc     1380

acatttcgga taccctacta tgtaggcccc ctcgcccggg gaaattccag attcgcgtgg     1440

atgactcgca aatcagaaga gaccatcact ccctggaact tcgaggaagt cgtggataag     1500

ggggcctctg cccagtcctt catcgaaagg atgactaact ttgataaaaa tctgcctaac     1560

gaaaaggtgc ttcctaaaca ctctctgctg tacgagtact tcacagttta taacgagctc     1620

accaaggtca aatacgtcac agaagggatg agaaagccag cattcctgtc tggagagcag     1680

aagaaagcta tcgtggacct cctcttcaag acgaaccgga aagttaccgt gaaacagctc     1740

aaagaagact atttcaaaaa gattgaatgt ttcgactctg ttgaaatcag cggagtggag     1800

gatcgcttca acgcatccct gggaacgtat cacgatctcc tgaaaatcat taaagacaag     1860

gacttcctgg acaatgagga gaacgaggac attcttgagg acattgtcct cacccttacg     1920

ttgtttgaag atagggagat gattgaagaa cgcttgaaaa cttacgctca tctcttcgac     1980

gacaaagtca tgaaacagct caagaggcgc cgatatacag gatgggggcg gctgtcaaga     2040

aaactgatca atgggatccg agacaagcag agtggaaaga caatcctgga ttttcttaag     2100

tccgatggat ttgccaaccg gaacttcatg cagttgatcc atgatgactc tctcaccttt     2160

aaggaggaca tccagaaagc acaagtttgt ctggctggcg atactctcat taccctggcc     2220

gatggacgac gagtgcctat tagagaactg gtgtcacagc agaatttttc cgtgtgggct     2280

ctgaatcctc agacttaccg cctggagagg gctagagtga gtagagcttt ctgtaccggc     2340

atcaaacctg tgtaccgcct caccactaga ctggggagat ccattagggc cactgccaac     2400

caccgatttc tcacacctca gggctggaaa cgagtcgatg aactccagcc tggagattac     2460

ctggctctgc ctaggagaat ccctactgcc tcctga                               2496


<210> 40
<211> 970
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 40
Met Ala Ala Ala Cys Pro Glu Leu Arg Gln Leu Ala Gln Ser Asp Val 
1               5                   10                  15      


Tyr Trp Asp Pro Ile Val Ser Ile Glu Pro Asp Gly Val Glu Glu Val 
            20                  25                  30          


Phe Asp Leu Thr Val Pro Gly Pro His Asn Phe Val Ala Asn Asp Ile 
        35                  40                  45              


Ile Ala His Asn Ser Gly Gln Gly Asp Ser Leu His Glu His Ile Ala 
    50                  55                  60                  


Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly Ile Leu Gln Thr Val 
65                  70                  75                  80  


Lys Val Val Asp Glu Leu Val Lys Val Met Gly Arg His Lys Pro Glu 
                85                  90                  95      


Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln Thr Thr Gln Lys Gly 
            100                 105                 110         


Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile Glu Glu Gly Ile Lys 
        115                 120                 125             


Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro Val Glu Asn Thr Gln 
    130                 135                 140                 


Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu Gln Asn Gly Arg Asp 
145                 150                 155                 160 


Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg Leu Ser Asp Tyr Asp 
                165                 170                 175     


Val Asp His Ile Val Pro Gln Ser Phe Leu Lys Asp Asp Ser Ile Asp 
            180                 185                 190         


Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg Gly Lys Ser Asp Asn 
        195                 200                 205             


Val Pro Ser Glu Glu Val Val Lys Lys Met Lys Asn Tyr Trp Arg Gln 
    210                 215                 220                 


Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys Phe Asp Asn Leu Thr 
225                 230                 235                 240 


Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp Lys Ala Gly Phe Ile 
                245                 250                 255     


Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr Lys His Val Ala Gln 
            260                 265                 270         


Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp Glu Asn Asp Lys Leu 
        275                 280                 285             


Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser Lys Leu Val Ser Asp 
    290                 295                 300                 


Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg Glu Ile Asn Asn Tyr 
305                 310                 315                 320 


His His Ala His Asp Ala Tyr Leu Asn Ala Val Val Gly Thr Ala Leu 
                325                 330                 335     


Ile Lys Lys Tyr Pro Lys Leu Glu Ser Glu Phe Val Tyr Gly Asp Tyr 
            340                 345                 350         


Lys Val Tyr Asp Val Arg Lys Met Ile Ala Lys Ser Glu Gln Glu Ile 
        355                 360                 365             


Gly Lys Ala Thr Ala Lys Tyr Phe Phe Tyr Ser Asn Ile Met Asn Phe 
    370                 375                 380                 


Phe Lys Thr Glu Ile Thr Leu Ala Asn Gly Glu Ile Arg Lys Arg Pro 
385                 390                 395                 400 


Leu Ile Glu Thr Asn Gly Glu Thr Gly Glu Ile Val Trp Asp Lys Gly 
                405                 410                 415     


Arg Asp Phe Ala Thr Val Arg Lys Val Leu Ser Met Pro Gln Val Asn 
            420                 425                 430         


Ile Val Lys Lys Thr Glu Val Gln Thr Gly Gly Phe Ser Lys Glu Ser 
        435                 440                 445             


Ile Leu Pro Lys Arg Asn Ser Asp Lys Leu Ile Ala Arg Lys Lys Asp 
    450                 455                 460                 


Trp Asp Pro Lys Lys Tyr Gly Gly Phe Asp Ser Pro Thr Val Ala Tyr 
465                 470                 475                 480 


Ser Val Leu Val Val Ala Lys Val Glu Lys Gly Lys Ser Lys Lys Leu 
                485                 490                 495     


Lys Ser Val Lys Glu Leu Leu Gly Ile Thr Ile Met Glu Arg Ser Ser 
            500                 505                 510         


Phe Glu Lys Asn Pro Ile Asp Phe Leu Glu Ala Lys Gly Tyr Lys Glu 
        515                 520                 525             


Val Lys Lys Asp Leu Ile Ile Lys Leu Pro Lys Tyr Ser Leu Phe Glu 
    530                 535                 540                 


Leu Glu Asn Gly Arg Lys Arg Met Leu Ala Ser Ala Gly Glu Leu Gln 
545                 550                 555                 560 


Lys Gly Asn Glu Leu Ala Leu Pro Ser Lys Tyr Val Asn Phe Leu Tyr 
                565                 570                 575     


Leu Ala Ser His Tyr Glu Lys Leu Lys Gly Ser Pro Glu Asp Asn Glu 
            580                 585                 590         


Gln Lys Gln Leu Phe Val Glu Gln His Lys His Tyr Leu Asp Glu Ile 
        595                 600                 605             


Ile Glu Gln Ile Ser Glu Phe Ser Lys Arg Val Ile Leu Ala Asp Ala 
    610                 615                 620                 


Asn Leu Asp Lys Val Leu Ser Ala Tyr Asn Lys His Arg Asp Lys Pro 
625                 630                 635                 640 


Ile Arg Glu Gln Ala Glu Asn Ile Ile His Leu Phe Thr Leu Thr Asn 
                645                 650                 655     


Leu Gly Ala Pro Ala Ala Phe Lys Tyr Phe Asp Thr Thr Ile Asp Arg 
            660                 665                 670         


Lys Arg Tyr Thr Ser Thr Lys Glu Val Leu Asp Ala Thr Leu Ile His 
        675                 680                 685             


Gln Ser Ile Thr Gly Leu Tyr Glu Thr Arg Ile Asp Leu Ser Gln Leu 
    690                 695                 700                 


Gly Gly Asp Ser Arg Ala Asp Pro Lys Lys Lys Arg Lys Val Ser Arg 
705                 710                 715                 720 


Ala Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp 
                725                 730                 735     


Val Glu Glu Asn Pro Gly Pro Met Pro Ala Met Lys Ile Glu Cys Arg 
            740                 745                 750         


Ile Thr Gly Thr Leu Asn Gly Val Glu Phe Glu Leu Val Gly Gly Gly 
        755                 760                 765             


Glu Gly Thr Pro Glu Gln Gly Arg Met Thr Asn Lys Met Lys Ser Thr 
    770                 775                 780                 


Lys Gly Ala Leu Thr Phe Ser Pro Tyr Leu Leu Ser His Val Met Gly 
785                 790                 795                 800 


Tyr Gly Phe Tyr His Phe Gly Thr Tyr Pro Ser Gly Tyr Glu Asn Pro 
                805                 810                 815     


Phe Leu His Ala Ile Asn Asn Gly Gly Tyr Thr Asn Thr Arg Ile Glu 
            820                 825                 830         


Lys Tyr Glu Asp Gly Gly Val Leu His Val Ser Phe Ser Tyr Arg Tyr 
        835                 840                 845             


Glu Ala Gly Arg Val Ile Gly Asp Phe Lys Val Val Gly Thr Gly Phe 
    850                 855                 860                 


Pro Glu Asp Ser Val Ile Phe Thr Asp Lys Ile Ile Arg Ser Asn Ala 
865                 870                 875                 880 


Thr Val Glu His Leu His Pro Met Gly Asp Asn Val Leu Val Gly Ser 
                885                 890                 895     


Phe Ala Arg Thr Phe Ser Leu Arg Asp Gly Gly Tyr Tyr Ser Phe Val 
            900                 905                 910         


Val Asp Ser His Met His Phe Lys Ser Ala Ile His Pro Ser Ile Leu 
        915                 920                 925             


Gln Asn Gly Gly Pro Met Phe Ala Phe Arg Arg Val Glu Glu Leu His 
    930                 935                 940                 


Ser Asn Thr Glu Leu Gly Ile Val Glu Tyr Gln His Ala Phe Lys Thr 
945                 950                 955                 960 


Pro Ile Ala Phe Ala Arg Ser Arg Ala Arg 
                965                 970 


<210> 41
<211> 2913
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 41
atggcggcgg cgtgcccgga actgcgtcag ctggcgcaga gcgatgtgta ttgggatccg       60

attgtgagca ttgaaccgga tggcgtggaa gaagtgtttg atctgaccgt gccgggcccg      120

cataactttg tggcgaacga tattattgcg cataactctg gccaggggga cagtcttcac      180

gagcacatcg ctaatcttgc aggtagccca gctatcaaaa agggaatact gcagaccgtt      240

aaggtcgtgg atgaactcgt caaagtaatg ggaaggcata agcccgagaa tatcgttatc      300

gagatggccc gagagaacca aactacccag aagggacaga agaacagtag ggaaaggatg      360

aagaggattg aagagggtat aaaagaactg gggtcccaaa tccttaagga acacccagtt      420

gaaaacaccc agcttcagaa tgagaagctc tacctgtact acctgcagaa cggcagggac      480

atgtacgtgg atcaggaact ggacatcaat cggctctccg actacgacgt ggatcatatc      540

gtgccccagt cttttctcaa agatgattct attgataata aagtgttgac aagatccgat      600

aaaaatagag ggaagagtga taacgtcccc tcagaagaag ttgtcaagaa aatgaaaaat      660

tattggcggc agctgctgaa cgccaaactg atcacacaac ggaagttcga taatctgact      720

aaggctgaac gaggtggcct gtctgagttg gataaagccg gcttcatcaa aaggcagctt      780

gttgagacac gccagatcac caagcacgtg gcccaaattc tcgattcacg catgaacacc      840

aagtacgatg aaaatgacaa actgattcga gaggtgaaag ttattactct gaagtctaag      900

ctggtctcag atttcagaaa ggactttcag ttttataagg tgagagagat caacaattac      960

caccatgcgc atgatgccta cctgaatgca gtggtaggca ctgcacttat caaaaaatat     1020

cccaagcttg aatctgaatt tgtttacgga gactataaag tgtacgatgt taggaaaatg     1080

atcgcaaagt ctgagcagga aataggcaag gccaccgcta agtacttctt ttacagcaat     1140

attatgaatt ttttcaagac cgagattaca ctggccaatg gagagattcg gaagcgacca     1200

cttatcgaaa caaacggaga aacaggagaa atcgtgtggg acaagggtag ggatttcgcg     1260

acagtccgga aggtcctgtc catgccgcag gtgaacatcg ttaaaaagac cgaagtacag     1320

accggaggct tctccaagga aagtatcctc ccgaaaagga acagcgacaa gctgatcgca     1380

cgcaaaaaag attgggaccc caagaaatac ggcggattcg attctcctac agtcgcttac     1440

agtgtactgg ttgtggccaa agtggagaaa gggaagtcta aaaaactcaa aagcgtcaag     1500

gaactgctgg gcatcacaat catggagcga tcaagcttcg aaaaaaaccc catcgacttt     1560

ctcgaggcga aaggatataa agaggtcaaa aaagacctca tcattaagct tcccaagtac     1620

tctctctttg agcttgaaaa cggccggaaa cgaatgctcg ctagtgcggg cgagctgcag     1680

aaaggtaacg agctggcact gccctctaaa tacgttaatt tcttgtatct ggccagccac     1740

tatgaaaagc tcaaagggtc tcccgaagat aatgagcaga agcagctgtt cgtggaacaa     1800

cacaaacact accttgatga gatcatcgag caaataagcg aattctccaa aagagtgatc     1860

ctcgccgacg ctaacctcga taaggtgctt tctgcttaca ataagcacag ggataagccc     1920

atcagggagc aggcagaaaa cattatccac ttgtttactc tgaccaactt gggcgcgcct     1980

gcagccttca agtacttcga caccaccata gacagaaagc ggtacacctc tacaaaggag     2040

gtcctggacg ccacactgat tcatcagtca attacggggc tctatgaaac aagaatcgac     2100

ctctctcagc tcggtggaga cagcagggct gaccccaaga agaagaggaa ggtgtctcga     2160

gctggatccg gagccacgaa cttctctctg ttaaagcaag caggggacgt ggaagaaaac     2220

cccggtccta tgcccgccat gaagatcgag tgccgcatca ccggcaccct gaacggcgtg     2280

gagttcgagc tggtgggcgg cggagagggc acccccgagc agggccgcat gaccaacaag     2340

atgaagagca ccaaaggcgc cctgaccttc agcccctacc tgctgagcca cgtgatgggc     2400

tacggcttct accacttcgg cacctacccc agcggctacg agaacccctt cctgcacgcc     2460

atcaacaacg gcggctacac caacacccgc atcgagaagt acgaggacgg cggcgtgctg     2520

cacgtgagct tcagctaccg ctacgaggcc ggccgcgtga tcggcgactt caaggtggtg     2580

ggcaccggct tccccgagga cagcgtgatc ttcaccgaca agatcatccg cagcaacgcc     2640

accgtggagc acctgcaccc catgggcgat aacgtgctgg tgggcagctt cgcccgcacc     2700

ttcagcctgc gcgacggcgg ctactacagc ttcgtggtgg acagccacat gcacttcaag     2760

agcgccatcc accccagcat cctgcagaac gggggcccca tgttcgcctt ccgccgcgtg     2820

gaggagctgc acagcaacac cgagctgggc atcgtggagt accagcacgc cttcaagacc     2880

cccatcgcct tcgccagatc tcgagctcga tga                                  2913


<210> 42
<211> 1271
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 42
Met Ala Ala Ala Cys Pro Glu Leu Arg Gln Leu Ala Gln Ser Asp Val 
1               5                   10                  15      


Tyr Trp Asp Pro Ile Val Ser Ile Glu Pro Asp Gly Val Glu Glu Val 
            20                  25                  30          


Phe Asp Leu Thr Val Pro Gly Pro His Asn Phe Val Ala Asn Asp Ile 
        35                  40                  45              


Ile Ala His Asn Ser Gly Gln Gly Asp Ser Leu His Glu His Ile Ala 
    50                  55                  60                  


Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly Ile Leu Gln Thr Val 
65                  70                  75                  80  


Lys Val Val Asp Glu Leu Val Lys Val Met Gly Arg His Lys Pro Glu 
                85                  90                  95      


Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln Thr Thr Gln Lys Gly 
            100                 105                 110         


Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile Glu Glu Gly Ile Lys 
        115                 120                 125             


Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro Val Glu Asn Thr Gln 
    130                 135                 140                 


Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu Gln Asn Gly Arg Asp 
145                 150                 155                 160 


Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg Leu Ser Asp Tyr Asp 
                165                 170                 175     


Val Asp His Ile Val Pro Gln Ser Phe Leu Lys Asp Asp Ser Ile Asp 
            180                 185                 190         


Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg Gly Lys Ser Asp Asn 
        195                 200                 205             


Val Pro Ser Glu Glu Val Val Lys Lys Met Lys Asn Tyr Trp Arg Gln 
    210                 215                 220                 


Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys Phe Asp Asn Leu Thr 
225                 230                 235                 240 


Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp Lys Ala Gly Phe Ile 
                245                 250                 255     


Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr Lys His Val Ala Gln 
            260                 265                 270         


Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp Glu Asn Asp Lys Leu 
        275                 280                 285             


Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser Lys Leu Val Ser Asp 
    290                 295                 300                 


Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg Glu Ile Asn Asn Tyr 
305                 310                 315                 320 


His His Ala His Asp Ala Tyr Leu Asn Ala Val Val Gly Thr Ala Leu 
                325                 330                 335     


Ile Lys Lys Tyr Pro Lys Leu Glu Ser Glu Phe Val Tyr Gly Asp Tyr 
            340                 345                 350         


Lys Val Tyr Asp Val Arg Lys Met Ile Ala Lys Ser Glu Gln Glu Ile 
        355                 360                 365             


Gly Lys Ala Thr Ala Lys Tyr Phe Phe Tyr Ser Asn Ile Met Asn Phe 
    370                 375                 380                 


Phe Lys Thr Glu Ile Thr Leu Ala Asn Gly Glu Ile Arg Lys Arg Pro 
385                 390                 395                 400 


Leu Ile Glu Thr Asn Gly Glu Thr Gly Glu Ile Val Trp Asp Lys Gly 
                405                 410                 415     


Arg Asp Phe Ala Thr Val Arg Lys Val Leu Ser Met Pro Gln Val Asn 
            420                 425                 430         


Ile Val Lys Lys Thr Glu Val Gln Thr Gly Gly Phe Ser Lys Glu Ser 
        435                 440                 445             


Ile Leu Pro Lys Arg Asn Ser Asp Lys Leu Ile Ala Arg Lys Lys Asp 
    450                 455                 460                 


Trp Asp Pro Lys Lys Tyr Gly Gly Phe Asp Ser Pro Thr Val Ala Tyr 
465                 470                 475                 480 


Ser Val Leu Val Val Ala Lys Val Glu Lys Gly Lys Ser Lys Lys Leu 
                485                 490                 495     


Lys Ser Val Lys Glu Leu Leu Gly Ile Thr Ile Met Glu Arg Ser Ser 
            500                 505                 510         


Phe Glu Lys Asn Pro Ile Asp Phe Leu Glu Ala Lys Gly Tyr Lys Glu 
        515                 520                 525             


Val Lys Lys Asp Leu Ile Ile Lys Leu Pro Lys Tyr Ser Leu Phe Glu 
    530                 535                 540                 


Leu Glu Asn Gly Arg Lys Arg Met Leu Ala Ser Ala Gly Glu Leu Gln 
545                 550                 555                 560 


Lys Gly Asn Glu Leu Ala Leu Pro Ser Lys Tyr Val Asn Phe Leu Tyr 
                565                 570                 575     


Leu Ala Ser His Tyr Glu Lys Leu Lys Gly Ser Pro Glu Asp Asn Glu 
            580                 585                 590         


Gln Lys Gln Leu Phe Val Glu Gln His Lys His Tyr Leu Asp Glu Ile 
        595                 600                 605             


Ile Glu Gln Ile Ser Glu Phe Ser Lys Arg Val Ile Leu Ala Asp Ala 
    610                 615                 620                 


Asn Leu Asp Lys Val Leu Ser Ala Tyr Asn Lys His Arg Asp Lys Pro 
625                 630                 635                 640 


Ile Arg Glu Gln Ala Glu Asn Ile Ile His Leu Phe Thr Leu Thr Asn 
                645                 650                 655     


Leu Gly Ala Pro Ala Ala Phe Lys Tyr Phe Asp Thr Thr Ile Asp Arg 
            660                 665                 670         


Lys Arg Tyr Thr Ser Thr Lys Glu Val Leu Asp Ala Thr Leu Ile His 
        675                 680                 685             


Gln Ser Ile Thr Gly Leu Tyr Glu Thr Arg Ile Asp Leu Ser Gln Leu 
    690                 695                 700                 


Gly Gly Asp Ser Arg Ala Asp Pro Lys Lys Lys Arg Lys Val Ser Pro 
705                 710                 715                 720 


Gly Ile Arg Arg Leu Asp Ala Leu Ile Ser Thr Ser Leu Tyr Lys Lys 
                725                 730                 735     


Ala Gly Tyr Lys Glu Ala Ser Gly Ser Gly Arg Ala Asp Ala Leu Asp 
            740                 745                 750         


Asp Phe Asp Leu Asp Met Leu Gly Ser Asp Ala Leu Asp Asp Phe Asp 
        755                 760                 765             


Leu Asp Met Leu Gly Ser Asp Ala Leu Asp Asp Phe Asp Leu Asp Met 
    770                 775                 780                 


Leu Gly Ser Asp Ala Leu Asp Asp Phe Asp Leu Asp Met Leu Ile Asn 
785                 790                 795                 800 


Ser Arg Ser Ser Gly Ser Pro Lys Lys Lys Arg Lys Val Gly Ser Gln 
                805                 810                 815     


Tyr Leu Pro Asp Thr Asp Asp Arg His Arg Ile Glu Glu Lys Arg Lys 
            820                 825                 830         


Arg Thr Tyr Glu Thr Phe Lys Ser Ile Met Lys Lys Ser Pro Phe Ser 
        835                 840                 845             


Gly Pro Thr Asp Pro Arg Pro Pro Pro Arg Arg Ile Ala Val Pro Ser 
    850                 855                 860                 


Arg Ser Ser Ala Ser Val Pro Lys Pro Ala Pro Gln Pro Tyr Pro Phe 
865                 870                 875                 880 


Thr Ser Ser Leu Ser Thr Ile Asn Tyr Asp Glu Phe Pro Thr Met Val 
                885                 890                 895     


Phe Pro Ser Gly Gln Ile Ser Gln Ala Ser Ala Leu Ala Pro Ala Pro 
            900                 905                 910         


Pro Gln Val Leu Pro Gln Ala Pro Ala Pro Ala Pro Ala Pro Ala Met 
        915                 920                 925             


Val Ser Ala Leu Ala Gln Ala Pro Ala Pro Val Pro Val Leu Ala Pro 
    930                 935                 940                 


Gly Pro Pro Gln Ala Val Ala Pro Pro Ala Pro Lys Pro Thr Gln Ala 
945                 950                 955                 960 


Gly Glu Gly Thr Leu Ser Glu Ala Leu Leu Gln Leu Gln Phe Asp Asp 
                965                 970                 975     


Glu Asp Leu Gly Ala Leu Leu Gly Asn Ser Thr Asp Pro Ala Val Phe 
            980                 985                 990         


Thr Asp Leu Ala Ser Val Asp Asn  Ser Glu Phe Gln Gln  Leu Leu Asn 
        995                 1000                 1005             


Gln Gly  Ile Pro Val Ala Pro  His Thr Thr Glu Pro  Met Leu Met 
    1010                 1015                 1020             


Glu Tyr  Pro Glu Ala Ile Thr  Arg Leu Val Thr Gly  Ala Gln Arg 
    1025                 1030                 1035             


Pro Pro  Asp Pro Ala Pro Ala  Pro Leu Gly Ala Pro  Gly Leu Pro 
    1040                 1045                 1050             


Asn Gly  Leu Leu Ser Gly Asp  Glu Asp Phe Ser Ser  Ile Ala Asp 
    1055                 1060                 1065             


Met Asp  Phe Ser Ala Leu Leu  Gly Ser Gly Ser Gly  Ser Arg Asp 
    1070                 1075                 1080             


Ser Arg  Glu Gly Met Phe Leu  Pro Lys Pro Glu Ala  Gly Ser Ala 
    1085                 1090                 1095             


Ile Ser  Asp Val Phe Glu Gly  Arg Glu Val Cys Gln  Pro Lys Arg 
    1100                 1105                 1110             


Ile Arg  Pro Phe His Pro Pro  Gly Ser Pro Trp Ala  Asn Arg Pro 
    1115                 1120                 1125             


Leu Pro  Ala Ser Leu Ala Pro  Thr Pro Thr Gly Pro  Val His Glu 
    1130                 1135                 1140             


Pro Val  Gly Ser Leu Thr Pro  Ala Pro Val Pro Gln  Pro Leu Asp 
    1145                 1150                 1155             


Pro Ala  Pro Ala Val Thr Pro  Glu Ala Ser His Leu  Leu Glu Asp 
    1160                 1165                 1170             


Pro Asp  Glu Glu Thr Ser Gln  Ala Val Lys Ala Leu  Arg Glu Met 
    1175                 1180                 1185             


Ala Asp  Thr Val Ile Pro Gln  Lys Glu Glu Ala Ala  Ile Cys Gly 
    1190                 1195                 1200             


Gln Met  Asp Leu Ser His Pro  Pro Pro Arg Gly His  Leu Asp Glu 
    1205                 1210                 1215             


Leu Thr  Thr Thr Leu Glu Ser  Met Thr Glu Asp Leu  Asn Leu Asp 
    1220                 1225                 1230             


Ser Pro  Leu Thr Pro Glu Leu  Asn Glu Ile Leu Asp  Thr Phe Leu 
    1235                 1240                 1245             


Asn Asp  Glu Cys Leu Leu His  Ala Met His Ile Ser  Thr Gly Leu 
    1250                 1255                 1260             


Ser Ile  Phe Asp Thr Ser Leu  Phe 
    1265                 1270     


<210> 43
<211> 3816
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 43
atggcggcgg cgtgcccgga actgcgtcag ctggcgcaga gcgatgtgta ttgggatccg       60

attgtgagca ttgaaccgga tggcgtggaa gaagtgtttg atctgaccgt gccgggcccg      120

cataactttg tggcgaacga tattattgcg cataactctg gccaggggga cagtcttcac      180

gagcacatcg ctaatcttgc aggtagccca gctatcaaaa agggaatact gcagaccgtt      240

aaggtcgtgg atgaactcgt caaagtaatg ggaaggcata agcccgagaa tatcgttatc      300

gagatggccc gagagaacca aactacccag aagggacaga agaacagtag ggaaaggatg      360

aagaggattg aagagggtat aaaagaactg gggtcccaaa tccttaagga acacccagtt      420

gaaaacaccc agcttcagaa tgagaagctc tacctgtact acctgcagaa cggcagggac      480

atgtacgtgg atcaggaact ggacatcaat cggctctccg actacgacgt ggatcatatc      540

gtgccccagt cttttctcaa agatgattct attgataata aagtgttgac aagatccgat      600

aaaaatagag ggaagagtga taacgtcccc tcagaagaag ttgtcaagaa aatgaaaaat      660

tattggcggc agctgctgaa cgccaaactg atcacacaac ggaagttcga taatctgact      720

aaggctgaac gaggtggcct gtctgagttg gataaagccg gcttcatcaa aaggcagctt      780

gttgagacac gccagatcac caagcacgtg gcccaaattc tcgattcacg catgaacacc      840

aagtacgatg aaaatgacaa actgattcga gaggtgaaag ttattactct gaagtctaag      900

ctggtctcag atttcagaaa ggactttcag ttttataagg tgagagagat caacaattac      960

caccatgcgc atgatgccta cctgaatgca gtggtaggca ctgcacttat caaaaaatat     1020

cccaagcttg aatctgaatt tgtttacgga gactataaag tgtacgatgt taggaaaatg     1080

atcgcaaagt ctgagcagga aataggcaag gccaccgcta agtacttctt ttacagcaat     1140

attatgaatt ttttcaagac cgagattaca ctggccaatg gagagattcg gaagcgacca     1200

cttatcgaaa caaacggaga aacaggagaa atcgtgtggg acaagggtag ggatttcgcg     1260

acagtccgga aggtcctgtc catgccgcag gtgaacatcg ttaaaaagac cgaagtacag     1320

accggaggct tctccaagga aagtatcctc ccgaaaagga acagcgacaa gctgatcgca     1380

cgcaaaaaag attgggaccc caagaaatac ggcggattcg attctcctac agtcgcttac     1440

agtgtactgg ttgtggccaa agtggagaaa gggaagtcta aaaaactcaa aagcgtcaag     1500

gaactgctgg gcatcacaat catggagcga tcaagcttcg aaaaaaaccc catcgacttt     1560

ctcgaggcga aaggatataa agaggtcaaa aaagacctca tcattaagct tcccaagtac     1620

tctctctttg agcttgaaaa cggccggaaa cgaatgctcg ctagtgcggg cgagctgcag     1680

aaaggtaacg agctggcact gccctctaaa tacgttaatt tcttgtatct ggccagccac     1740

tatgaaaagc tcaaagggtc tcccgaagat aatgagcaga agcagctgtt cgtggaacaa     1800

cacaaacact accttgatga gatcatcgag caaataagcg aattctccaa aagagtgatc     1860

ctcgccgacg ctaacctcga taaggtgctt tctgcttaca ataagcacag ggataagccc     1920

atcagggagc aggcagaaaa cattatccac ttgtttactc tgaccaactt gggcgcgcct     1980

gcagccttca agtacttcga caccaccata gacagaaagc ggtacacctc tacaaaggag     2040

gtcctggacg ccacactgat tcatcagtca attacggggc tctatgaaac aagaatcgac     2100

ctctctcagc tcggtggaga cagcagggct gaccccaaga agaagaggaa ggtgtcgcca     2160

gggatccgtc gacttgacgc gttgatatca acaagtttgt acaaaaaagc aggctacaaa     2220

gaggccagcg gttccggacg ggctgacgca ttggacgatt ttgatctgga tatgctggga     2280

agtgacgccc tcgatgattt tgaccttgac atgcttggtt cggatgccct tgatgacttt     2340

gacctcgaca tgctcggcag tgacgccctt gatgatttcg acctggacat gctgattaac     2400

tctagaagtt ccggatctcc gaaaaagaaa cgcaaagttg gtagccagta cctgcccgac     2460

accgacgacc ggcaccggat cgaggaaaag cggaagcgga cctacgagac attcaagagc     2520

atcatgaaga agtccccctt cagcggcccc accgacccta gacctccacc tagaagaatc     2580

gccgtgccca gcagatccag cgccagcgtg ccaaaacctg ccccccagcc ttaccccttc     2640

accagcagcc tgagcaccat caactacgac gagttcccta ccatggtgtt ccccagcggc     2700

cagatctctc aggcctctgc tctggctcca gcccctcctc aggtgctgcc tcaggctcct     2760

gctcctgcac cagctccagc catggtgtct gcactggctc aggcaccagc acccgtgcct     2820

gtgctggctc ctggacctcc acaggctgtg gctccaccag cccctaaacc tacacaggcc     2880

ggcgagggca cactgtctga agctctgctg cagctgcagt tcgacgacga ggatctggga     2940

gccctgctgg gaaacagcac cgatcctgcc gtgttcaccg acctggccag cgtggacaac     3000

agcgagttcc agcagctgct gaaccagggc atccctgtgg cccctcacac caccgagccc     3060

atgctgatgg aataccccga ggccatcacc cggctcgtga caggcgctca gaggcctcct     3120

gatccagctc ctgcccctct gggagcacca ggcctgccta atggactgct gtctggcgac     3180

gaggacttca gctctatcgc cgatatggat ttctcagcct tgctgggctc tggcagcggc     3240

agccgggatt ccagggaagg gatgtttttg ccgaagcctg aggccggctc cgctattagt     3300

gacgtgtttg agggccgcga ggtgtgccag ccaaaacgaa tccggccatt tcatcctcca     3360

ggaagtccat gggccaaccg cccactcccc gccagcctcg caccaacacc aaccggtcca     3420

gtacatgagc cagtcgggtc actgaccccg gcaccagtcc ctcagccact ggatccagcg     3480

cccgcagtga ctcccgaggc cagtcacctg ttggaggatc ccgatgaaga gacgagccag     3540

gctgtcaaag cccttcggga gatggccgat actgtgattc cccagaagga agaggctgca     3600

atctgtggcc aaatggacct ttcccatccg cccccaaggg gccatctgga tgagctgaca     3660

accacacttg agtccatgac cgaggatctg aacctggact cacccctgac cccggaattg     3720

aacgagattc tggatacctt cctgaacgac gagtgcctct tgcatgccat gcatatcagc     3780

acaggactgt ccatcttcga cacatctctg ttttga                               3816


<210> 44
<211> 23
<212> DNA
<213> Mus sp.

<400> 44
aagtctctcc gggacctctt ggg                                               23


<210> 45
<211> 23
<212> DNA
<213> Mus sp.

<400> 45
aaggctctcc aggacctctt ggg                                               23


<210> 46
<211> 23
<212> DNA
<213> Mus sp.

<400> 46
aagtatctct gggacctctt cag                                               23


<210> 47
<211> 23
<212> DNA
<213> Mus sp.

<400> 47
gagtccctcc gggagctctt ggg                                               23


<210> 48
<211> 23
<212> DNA
<213> Mus sp.

<400> 48
gtgctgccgc taccccctca cgg                                               23


<210> 49
<211> 23
<212> DNA
<213> Mus sp.

<400> 49
gtgctgcagc tgccacctca ggg                                               23


<210> 50
<211> 23
<212> DNA
<213> Mus sp.

<400> 50
gtgcagccgc taccaccaca aag                                               23


