                         SEQUENCE LISTING

<110>  The Scripps Research Institute
 
<120>  Kv1.3-Blocking Venom Peptide Variants and Related Uses

<130>  1749.1PC

<140>  PCT/US2017/032102
<141>  2017-05-11

<150>  US 62/336,151
<151>  2016-05-13

<160>  13    

<170>  PatentIn version 3.5

<210>  1
<211>  280
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  1

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Tyr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Lys Gly Asn Ser Gly Gly Gly Gly Ser 
225                 230                 235                 240 


Gly Gly Gly Gly Ser Arg Ser Cys Val Asp Met Val Pro Lys Ser Arg 
                245                 250                 255     


Cys Thr Ala Phe Lys Cys Lys His Ser Met Lys Tyr Arg Leu Ser Phe 
            260                 265                 270         


Cys Arg Lys Thr Cys Gly Thr Cys 
        275                 280 


<210>  2
<211>  232
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  2

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Tyr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Lys 
225                 230         


<210>  3
<211>  13
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  3

Gly Asn Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10              


<210>  4
<211>  35
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  4

Arg Ser Cys Val Asp Met Val Pro Lys Ser Arg Cys Thr Ala Phe Lys 
1               5                   10                  15      


Cys Lys His Ser Met Lys Tyr Arg Leu Ser Phe Cys Arg Lys Thr Cys 
            20                  25                  30          


Gly Thr Cys 
        35  


<210>  5
<211>  0
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  5
000

<210>  6
<211>  35
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  6

Arg Ser Cys Ile Asp Thr Ile Pro Lys Ser Arg Cys Thr Ala Phe Lys 
1               5                   10                  15      


Cys Lys His Ser Met Lys Tyr Arg Leu Ser Phe Cys Arg Lys Thr Cys 
            20                  25                  30          


Gly Thr Cys 
        35  


<210>  7
<211>  35
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  7

Leu Arg Cys Phe Asp Leu Leu Pro Lys Ser Arg Cys Thr Ala Phe Lys 
1               5                   10                  15      


Cys Lys His Ser Met Lys Tyr Arg Leu Ser Phe Cys Arg Lys Thr Cys 
            20                  25                  30          


Gly Thr Cys 
        35  


<210>  8
<211>  15
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  8
ggcggaggtg gaagc                                                        15


<210>  9
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  9

Gly Gly Gly Gly Ser 
1               5   


<210>  10
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  10
tcttgcactt gtcacgaatt cg                                                22


<210>  11
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  11
gctagcgtcg actacggaga tg                                                22


<210>  12
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  12

Gly Gly Gly Gly Ser 
1               5   


<210>  13
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  13

Arg Ser Cys Val Asp Met Val 
1               5           


