                         SEQUENCE LISTING

<110>  Janssen Biotech, Inc.
       Anthony Armstrong
       Judith Ann Connor
       Jennifer Furman
       Chichi Huang
       Michael J. Hunter
       Xiefan Lin-Schmidt
       Serena Nelson
       Shamina Rangwala
       Shannon Mullican
       Jose Antonio Chavez
 
<120>  GDF15 Fusion Proteins and Uses Thereof

<130>  JBI5086WOPCT

<140>  Unknown
<141>  Herewith

<150>  62/333,886
<151>  05/10/2016

<160>  128   

<170>  PatentIn version 3.5

<210>  1
<211>  585
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HSA variant

<400>  1

Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu 
1               5                   10                  15      


Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln 
            20                  25                  30          


Gln Cys Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr Glu 
        35                  40                  45              


Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys 
    50                  55                  60                  


Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu 
65                  70                  75                  80  


Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro 
                85                  90                  95      


Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu 
            100                 105                 110         


Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe His 
        115                 120                 125             


Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg 
    130                 135                 140                 


Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg 
145                 150                 155                 160 


Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala 
                165                 170                 175     


Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser 
            180                 185                 190         


Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu 
        195                 200                 205             


Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro 
    210                 215                 220                 


Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys 
225                 230                 235                 240 


Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp 
                245                 250                 255     


Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser 
            260                 265                 270         


Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His 
        275                 280                 285             


Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser 
    290                 295                 300                 


Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala 
305                 310                 315                 320 


Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg 
                325                 330                 335     


Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys Thr 
            340                 345                 350         


Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His Glu 
        355                 360                 365             


Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro 
    370                 375                 380                 


Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu 
385                 390                 395                 400 


Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro 
                405                 410                 415     


Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly Lys 
            420                 425                 430         


Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys 
        435                 440                 445             


Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu His 
    450                 455                 460                 


Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser 
465                 470                 475                 480 


Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr 
                485                 490                 495     


Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala Asp 
            500                 505                 510         


Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala 
        515                 520                 525             


Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln Leu 
    530                 535                 540                 


Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys Lys 
545                 550                 555                 560 


Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu Val 
                565                 570                 575     


Ala Ala Ser Gln Ala Ala Leu Gly Leu 
            580                 585 


<210>  2
<211>  585
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HSA variant

<400>  2

Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu 
1               5                   10                  15      


Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln 
            20                  25                  30          


Gln Ser Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr Glu 
        35                  40                  45              


Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys 
    50                  55                  60                  


Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu 
65                  70                  75                  80  


Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro 
                85                  90                  95      


Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu 
            100                 105                 110         


Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe His 
        115                 120                 125             


Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg 
    130                 135                 140                 


Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg 
145                 150                 155                 160 


Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala 
                165                 170                 175     


Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser 
            180                 185                 190         


Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu 
        195                 200                 205             


Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro 
    210                 215                 220                 


Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys 
225                 230                 235                 240 


Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp 
                245                 250                 255     


Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser 
            260                 265                 270         


Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His 
        275                 280                 285             


Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser 
    290                 295                 300                 


Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala 
305                 310                 315                 320 


Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg 
                325                 330                 335     


Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys Thr 
            340                 345                 350         


Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His Glu 
        355                 360                 365             


Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro 
    370                 375                 380                 


Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu 
385                 390                 395                 400 


Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro 
                405                 410                 415     


Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly Lys 
            420                 425                 430         


Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys 
        435                 440                 445             


Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu His 
    450                 455                 460                 


Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser 
465                 470                 475                 480 


Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr 
                485                 490                 495     


Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala Asp 
            500                 505                 510         


Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala 
        515                 520                 525             


Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln Leu 
    530                 535                 540                 


Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys Lys 
545                 550                 555                 560 


Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu Val 
                565                 570                 575     


Ala Ala Ser Gln Ala Ala Leu Gly Leu 
            580                 585 


<210>  3
<211>  585
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HSA variant

<400>  3

Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu 
1               5                   10                  15      


Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln 
            20                  25                  30          


Gln Ala Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr Glu 
        35                  40                  45              


Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys 
    50                  55                  60                  


Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu 
65                  70                  75                  80  


Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro 
                85                  90                  95      


Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu 
            100                 105                 110         


Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe His 
        115                 120                 125             


Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg 
    130                 135                 140                 


Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg 
145                 150                 155                 160 


Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala 
                165                 170                 175     


Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser 
            180                 185                 190         


Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu 
        195                 200                 205             


Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro 
    210                 215                 220                 


Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys 
225                 230                 235                 240 


Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp 
                245                 250                 255     


Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser 
            260                 265                 270         


Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His 
        275                 280                 285             


Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser 
    290                 295                 300                 


Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala 
305                 310                 315                 320 


Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg 
                325                 330                 335     


Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys Thr 
            340                 345                 350         


Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His Glu 
        355                 360                 365             


Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro 
    370                 375                 380                 


Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu 
385                 390                 395                 400 


Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro 
                405                 410                 415     


Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly Lys 
            420                 425                 430         


Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys 
        435                 440                 445             


Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu His 
    450                 455                 460                 


Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser 
465                 470                 475                 480 


Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr 
                485                 490                 495     


Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala Asp 
            500                 505                 510         


Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala 
        515                 520                 525             


Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln Leu 
    530                 535                 540                 


Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys Lys 
545                 550                 555                 560 


Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu Val 
                565                 570                 575     


Ala Ala Ser Gln Ala Ala Leu Gly Leu 
            580                 585 


<210>  4
<211>  20
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Linker

<400>  4

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser 
            20  


<210>  5
<211>  719
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fusion protein

<400>  5

Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu 
1               5                   10                  15      


Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln 
            20                  25                  30          


Gln Ser Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr Glu 
        35                  40                  45              


Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys 
    50                  55                  60                  


Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu 
65                  70                  75                  80  


Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro 
                85                  90                  95      


Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu 
            100                 105                 110         


Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe His 
        115                 120                 125             


Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg 
    130                 135                 140                 


Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg 
145                 150                 155                 160 


Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala 
                165                 170                 175     


Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser 
            180                 185                 190         


Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu 
        195                 200                 205             


Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro 
    210                 215                 220                 


Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys 
225                 230                 235                 240 


Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp 
                245                 250                 255     


Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser 
            260                 265                 270         


Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His 
        275                 280                 285             


Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser 
    290                 295                 300                 


Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala 
305                 310                 315                 320 


Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg 
                325                 330                 335     


Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys Thr 
            340                 345                 350         


Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His Glu 
        355                 360                 365             


Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro 
    370                 375                 380                 


Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu 
385                 390                 395                 400 


Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro 
                405                 410                 415     


Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly Lys 
            420                 425                 430         


Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys 
        435                 440                 445             


Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu His 
    450                 455                 460                 


Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser 
465                 470                 475                 480 


Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr 
                485                 490                 495     


Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala Asp 
            500                 505                 510         


Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala 
        515                 520                 525             


Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln Leu 
    530                 535                 540                 


Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys Lys 
545                 550                 555                 560 


Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu Val 
                565                 570                 575     


Ala Ala Ser Gln Ala Ala Leu Gly Leu Gly Ser Gly Gly Gly Gly Ser 
            580                 585                 590         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala 
        595                 600                 605             


Arg Asn Gly Asp His Cys Pro Leu Gly Pro Gly Arg Cys Cys Arg Leu 
    610                 615                 620                 


His Thr Val Arg Ala Ser Leu Glu Asp Leu Gly Trp Ala Asp Trp Val 
625                 630                 635                 640 


Leu Ser Pro Arg Glu Val Gln Val Thr Met Cys Ile Gly Ala Cys Pro 
                645                 650                 655     


Ser Gln Phe Arg Ala Ala Asn Met His Ala Gln Ile Lys Thr Ser Leu 
            660                 665                 670         


His Arg Leu Lys Pro Asp Thr Val Pro Ala Pro Cys Cys Val Pro Ala 
        675                 680                 685             


Ser Tyr Asn Pro Met Val Leu Ile Gln Lys Thr Asp Thr Gly Val Ser 
    690                 695                 700                 


Leu Gln Thr Tyr Asp Asp Leu Leu Ala Lys Asp Cys His Cys Ile 
705                 710                 715                 


<210>  6
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GDF15 variant

<400>  6

Ala Arg Asn Gly Asp His Cys Pro Leu Gly Pro Gly Arg Cys Cys Arg 
1               5                   10                  15      


Leu His Thr Val Arg Ala Ser Leu Glu Asp Leu Gly Trp Ala Asp Trp 
            20                  25                  30          


Val Leu Ser Pro Arg Glu Val Gln Val Thr Met Cys Ile Gly Ala Cys 
        35                  40                  45              


Pro Ser Gln Phe Arg Ala Ala Asn Met His Ala Gln Ile Lys Thr Ser 
    50                  55                  60                  


Leu His Arg Leu Lys Pro Asp Thr Val Pro Ala Pro Cys Cys Val Pro 
65                  70                  75                  80  


Ala Ser Tyr Asn Pro Met Val Leu Ile Gln Lys Thr Asp Thr Gly Val 
                85                  90                  95      


Ser Leu Gln Thr Tyr Asp Asp Leu Leu Ala Lys Asp Cys His Cys Ile 
            100                 105                 110         


<210>  7
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GDF15 variant

<400>  7

Gly Asp His Cys Pro Leu Gly Pro Gly Arg Cys Cys Arg Leu His Thr 
1               5                   10                  15      


Val Arg Ala Ser Leu Glu Asp Leu Gly Trp Ala Asp Trp Val Leu Ser 
            20                  25                  30          


Pro Arg Glu Val Gln Val Thr Met Cys Ile Gly Ala Cys Pro Ser Gln 
        35                  40                  45              


Phe Arg Ala Ala Asn Met His Ala Gln Ile Lys Thr Ser Leu His Arg 
    50                  55                  60                  


Leu Lys Pro Asp Thr Val Pro Ala Pro Cys Cys Val Pro Ala Ser Tyr 
65                  70                  75                  80  


Asn Pro Met Val Leu Ile Gln Lys Thr Asp Thr Gly Val Ser Leu Gln 
                85                  90                  95      


Thr Tyr Asp Asp Leu Leu Ala Lys Asp Cys His Cys Ile 
            100                 105                 


<210>  8
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GDF15 variant

<400>  8

Asp His Cys Pro Leu Gly Pro Gly Arg Cys Cys Arg Leu His Thr Val 
1               5                   10                  15      


Arg Ala Ser Leu Glu Asp Leu Gly Trp Ala Asp Trp Val Leu Ser Pro 
            20                  25                  30          


Arg Glu Val Gln Val Thr Met Cys Ile Gly Ala Cys Pro Ser Gln Phe 
        35                  40                  45              


Arg Ala Ala Asn Met His Ala Gln Ile Lys Thr Ser Leu His Arg Leu 
    50                  55                  60                  


Lys Pro Asp Thr Val Pro Ala Pro Cys Cys Val Pro Ala Ser Tyr Asn 
65                  70                  75                  80  


Pro Met Val Leu Ile Gln Lys Thr Asp Thr Gly Val Ser Leu Gln Thr 
                85                  90                  95      


Tyr Asp Asp Leu Leu Ala Lys Asp Cys His Cys Ile 
            100                 105             


<210>  9
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GDF15 variant

<400>  9

His Cys Pro Leu Gly Pro Gly Arg Cys Cys Arg Leu His Thr Val Arg 
1               5                   10                  15      


Ala Ser Leu Glu Asp Leu Gly Trp Ala Asp Trp Val Leu Ser Pro Arg 
            20                  25                  30          


Glu Val Gln Val Thr Met Cys Ile Gly Ala Cys Pro Ser Gln Phe Arg 
        35                  40                  45              


Ala Ala Asn Met His Ala Gln Ile Lys Thr Ser Leu His Arg Leu Lys 
    50                  55                  60                  


Pro Asp Thr Val Pro Ala Pro Cys Cys Val Pro Ala Ser Tyr Asn Pro 
65                  70                  75                  80  


Met Val Leu Ile Gln Lys Thr Asp Thr Gly Val Ser Leu Gln Thr Tyr 
                85                  90                  95      


Asp Asp Leu Leu Ala Lys Asp Cys His Cys Ile 
            100                 105         


<210>  10
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GDF15 variant

<400>  10

Cys Pro Leu Gly Pro Gly Arg Cys Cys Arg Leu His Thr Val Arg Ala 
1               5                   10                  15      


Ser Leu Glu Asp Leu Gly Trp Ala Asp Trp Val Leu Ser Pro Arg Glu 
            20                  25                  30          


Val Gln Val Thr Met Cys Ile Gly Ala Cys Pro Ser Gln Phe Arg Ala 
        35                  40                  45              


Ala Asn Met His Ala Gln Ile Lys Thr Ser Leu His Arg Leu Lys Pro 
    50                  55                  60                  


Asp Thr Val Pro Ala Pro Cys Cys Val Pro Ala Ser Tyr Asn Pro Met 
65                  70                  75                  80  


Val Leu Ile Gln Lys Thr Asp Thr Gly Val Ser Leu Gln Thr Tyr Asp 
                85                  90                  95      


Asp Leu Leu Ala Lys Asp Cys His Cys Ile 
            100                 105     


<210>  11
<211>  98
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GDF15 variant

<400>  11

Cys Arg Leu His Thr Val Arg Ala Ser Leu Glu Asp Leu Gly Trp Ala 
1               5                   10                  15      


Asp Trp Val Leu Ser Pro Arg Glu Val Gln Val Thr Met Cys Ile Gly 
            20                  25                  30          


Ala Cys Pro Ser Gln Phe Arg Ala Ala Asn Met His Ala Gln Ile Lys 
        35                  40                  45              


Thr Ser Leu His Arg Leu Lys Pro Asp Thr Val Pro Ala Pro Cys Cys 
    50                  55                  60                  


Val Pro Ala Ser Tyr Asn Pro Met Val Leu Ile Gln Lys Thr Asp Thr 
65                  70                  75                  80  


Gly Val Ser Leu Gln Thr Tyr Asp Asp Leu Leu Ala Lys Asp Cys His 
                85                  90                  95      


Cys Ile 
        


<210>  12
<211>  42
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Linker

<400>  12

Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
1               5                   10                  15      


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            20                  25                  30          


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        35                  40          


<210>  13
<211>  42
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Linker

<400>  13

Gly Ala Gly Gly Gly Gly Ala Gly Gly Gly Gly Ala Gly Gly Gly Gly 
1               5                   10                  15      


Ala Gly Gly Gly Gly Ala Gly Gly Gly Gly Ala Gly Gly Gly Gly Ala 
            20                  25                  30          


Gly Gly Gly Gly Ala Gly Gly Gly Gly Ala 
        35                  40          


<210>  14
<211>  20
<212>  PRT
<213>  Artificial sequence

<220>
<223>  linker

<400>  14

Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro 
1               5                   10                  15      


Ala Pro Ala Pro 
            20  


<210>  15
<211>  24
<212>  PRT
<213>  Artificial sequence

<220>
<223>  linker

<400>  15

Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro 
1               5                   10                  15      


Ala Pro Ala Pro Ala Pro Ala Pro 
            20                  


<210>  16
<211>  48
<212>  PRT
<213>  Artificial sequence

<220>
<223>  linker

<400>  16

Gly Gly Ser Glu Gly Lys Ser Ser Gly Ser Gly Ser Glu Ser Lys Ser 
1               5                   10                  15      


Thr Glu Gly Lys Ser Ser Gly Ser Gly Ser Glu Ser Lys Ser Thr Glu 
            20                  25                  30          


Gly Lys Ser Ser Gly Ser Gly Ser Glu Ser Lys Ser Thr Gly Gly Ser 
        35                  40                  45              


<210>  17
<211>  42
<212>  PRT
<213>  Artificial sequence

<220>
<223>  linker

<400>  17

Gly Ser Pro Gly Gly Gly Ser Pro Gly Gly Gly Ser Pro Gly Gly Gly 
1               5                   10                  15      


Ser Pro Gly Gly Gly Ser Pro Gly Gly Gly Ser Pro Gly Gly Gly Ser 
            20                  25                  30          


Pro Gly Gly Gly Ser Pro Gly Gly Gly Ser 
        35                  40          


<210>  18
<211>  42
<212>  PRT
<213>  Artificial sequence

<220>
<223>  linker

<400>  18

Gly Ser Ala Gly Gly Gly Ser Ala Gly Gly Gly Ser Ala Gly Gly Gly 
1               5                   10                  15      


Ser Ala Gly Gly Gly Ser Ala Gly Gly Gly Ser Ala Gly Gly Gly Ser 
            20                  25                  30          


Ala Gly Gly Gly Ser Ala Gly Gly Gly Ser 
        35                  40          


<210>  19
<211>  34
<212>  PRT
<213>  Artificial sequence

<220>
<223>  linker

<400>  19

Gly Gly Ser Glu Gly Lys Ser Ser Gly Ser Gly Ser Glu Ser Lys Ser 
1               5                   10                  15      


Thr Glu Gly Lys Ser Ser Gly Ser Gly Ser Glu Ser Lys Ser Thr Gly 
            20                  25                  30          


Gly Ser 
        


<210>  20
<211>  14
<212>  PRT
<213>  Artificial sequence

<220>
<223>  linker

<400>  20

Ala Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Thr 
1               5                   10                  


<210>  21
<211>  44
<212>  PRT
<213>  Artificial sequence

<220>
<223>  linker

<400>  21

Ala Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
1               5                   10                  15      


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            20                  25                  30          


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Thr 
        35                  40                  


<210>  22
<211>  14
<212>  PRT
<213>  Artificial sequence

<220>
<223>  linker

<400>  22

Ala Ser Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Gly Thr 
1               5                   10                  


<210>  23
<211>  24
<212>  PRT
<213>  Artificial sequence

<220>
<223>  linker

<400>  23

Ala Ser Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro 
1               5                   10                  15      


Ala Pro Ala Pro Ala Pro Gly Thr 
            20                  


<210>  24
<211>  44
<212>  PRT
<213>  Artificial sequence

<220>
<223>  linker

<400>  24

Ala Ser Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro 
1               5                   10                  15      


Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro 
            20                  25                  30          


Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Gly Thr 
        35                  40                  


<210>  25
<211>  711
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fusion protein

<400>  25

Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu 
1               5                   10                  15      


Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln 
            20                  25                  30          


Gln Ser Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr Glu 
        35                  40                  45              


Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys 
    50                  55                  60                  


Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu 
65                  70                  75                  80  


Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro 
                85                  90                  95      


Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu 
            100                 105                 110         


Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe His 
        115                 120                 125             


Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg 
    130                 135                 140                 


Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg 
145                 150                 155                 160 


Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala 
                165                 170                 175     


Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser 
            180                 185                 190         


Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu 
        195                 200                 205             


Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro 
    210                 215                 220                 


Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys 
225                 230                 235                 240 


Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp 
                245                 250                 255     


Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser 
            260                 265                 270         


Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His 
        275                 280                 285             


Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser 
    290                 295                 300                 


Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala 
305                 310                 315                 320 


Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg 
                325                 330                 335     


Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys Thr 
            340                 345                 350         


Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His Glu 
        355                 360                 365             


Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro 
    370                 375                 380                 


Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu 
385                 390                 395                 400 


Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro 
                405                 410                 415     


Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly Lys 
            420                 425                 430         


Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys 
        435                 440                 445             


Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu His 
    450                 455                 460                 


Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser 
465                 470                 475                 480 


Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr 
                485                 490                 495     


Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala Asp 
            500                 505                 510         


Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala 
        515                 520                 525             


Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln Leu 
    530                 535                 540                 


Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys Lys 
545                 550                 555                 560 


Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu Val 
                565                 570                 575     


Ala Ala Ser Gln Ala Ala Leu Gly Leu Ala Ser Gly Gly Gly Gly Ser 
            580                 585                 590         


Gly Gly Gly Gly Ser Gly Thr Ala Arg Asn Gly Asp His Cys Pro Leu 
        595                 600                 605             


Gly Pro Gly Arg Cys Cys Arg Leu His Thr Val Arg Ala Ser Leu Glu 
    610                 615                 620                 


Asp Leu Gly Trp Ala Asp Trp Val Leu Ser Pro Arg Glu Val Gln Val 
625                 630                 635                 640 


Thr Met Cys Ile Gly Ala Cys Pro Ser Gln Phe Arg Ala Ala Asn Met 
                645                 650                 655     


His Ala Gln Ile Lys Thr Ser Leu His Arg Leu Lys Pro Asp Thr Val 
            660                 665                 670         


Pro Ala Pro Cys Cys Val Pro Ala Ser Tyr Asn Pro Met Val Leu Ile 
        675                 680                 685             


Gln Lys Thr Asp Thr Gly Val Ser Leu Gln Thr Tyr Asp Asp Leu Leu 
    690                 695                 700                 


Ala Lys Asp Cys His Cys Ile 
705                 710     


<210>  26
<211>  741
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fusion protein

<400>  26

Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu 
1               5                   10                  15      


Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln 
            20                  25                  30          


Gln Ser Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr Glu 
        35                  40                  45              


Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys 
    50                  55                  60                  


Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu 
65                  70                  75                  80  


Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro 
                85                  90                  95      


Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu 
            100                 105                 110         


Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe His 
        115                 120                 125             


Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg 
    130                 135                 140                 


Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg 
145                 150                 155                 160 


Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala 
                165                 170                 175     


Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser 
            180                 185                 190         


Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu 
        195                 200                 205             


Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro 
    210                 215                 220                 


Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys 
225                 230                 235                 240 


Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp 
                245                 250                 255     


Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser 
            260                 265                 270         


Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His 
        275                 280                 285             


Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser 
    290                 295                 300                 


Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala 
305                 310                 315                 320 


Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg 
                325                 330                 335     


Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys Thr 
            340                 345                 350         


Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His Glu 
        355                 360                 365             


Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro 
    370                 375                 380                 


Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu 
385                 390                 395                 400 


Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro 
                405                 410                 415     


Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly Lys 
            420                 425                 430         


Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys 
        435                 440                 445             


Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu His 
    450                 455                 460                 


Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser 
465                 470                 475                 480 


Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr 
                485                 490                 495     


Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala Asp 
            500                 505                 510         


Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala 
        515                 520                 525             


Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln Leu 
    530                 535                 540                 


Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys Lys 
545                 550                 555                 560 


Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu Val 
                565                 570                 575     


Ala Ala Ser Gln Ala Ala Leu Gly Leu Ala Ser Gly Gly Gly Gly Ser 
            580                 585                 590         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        595                 600                 605             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    610                 615                 620                 


Gly Gly Ser Gly Thr Ala Arg Asn Gly Asp His Cys Pro Leu Gly Pro 
625                 630                 635                 640 


Gly Arg Cys Cys Arg Leu His Thr Val Arg Ala Ser Leu Glu Asp Leu 
                645                 650                 655     


Gly Trp Ala Asp Trp Val Leu Ser Pro Arg Glu Val Gln Val Thr Met 
            660                 665                 670         


Cys Ile Gly Ala Cys Pro Ser Gln Phe Arg Ala Ala Asn Met His Ala 
        675                 680                 685             


Gln Ile Lys Thr Ser Leu His Arg Leu Lys Pro Asp Thr Val Pro Ala 
    690                 695                 700                 


Pro Cys Cys Val Pro Ala Ser Tyr Asn Pro Met Val Leu Ile Gln Lys 
705                 710                 715                 720 


Thr Asp Thr Gly Val Ser Leu Gln Thr Tyr Asp Asp Leu Leu Ala Lys 
                725                 730                 735     


Asp Cys His Cys Ile 
            740     


<210>  27
<211>  711
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fusion protein

<400>  27

Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu 
1               5                   10                  15      


Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln 
            20                  25                  30          


Gln Ser Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr Glu 
        35                  40                  45              


Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys 
    50                  55                  60                  


Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu 
65                  70                  75                  80  


Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro 
                85                  90                  95      


Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu 
            100                 105                 110         


Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe His 
        115                 120                 125             


Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg 
    130                 135                 140                 


Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg 
145                 150                 155                 160 


Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala 
                165                 170                 175     


Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser 
            180                 185                 190         


Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu 
        195                 200                 205             


Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro 
    210                 215                 220                 


Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys 
225                 230                 235                 240 


Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp 
                245                 250                 255     


Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser 
            260                 265                 270         


Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His 
        275                 280                 285             


Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser 
    290                 295                 300                 


Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala 
305                 310                 315                 320 


Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg 
                325                 330                 335     


Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys Thr 
            340                 345                 350         


Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His Glu 
        355                 360                 365             


Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro 
    370                 375                 380                 


Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu 
385                 390                 395                 400 


Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro 
                405                 410                 415     


Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly Lys 
            420                 425                 430         


Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys 
        435                 440                 445             


Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu His 
    450                 455                 460                 


Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser 
465                 470                 475                 480 


Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr 
                485                 490                 495     


Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala Asp 
            500                 505                 510         


Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala 
        515                 520                 525             


Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln Leu 
    530                 535                 540                 


Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys Lys 
545                 550                 555                 560 


Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu Val 
                565                 570                 575     


Ala Ala Ser Gln Ala Ala Leu Gly Leu Ala Ser Ala Pro Ala Pro Ala 
            580                 585                 590         


Pro Ala Pro Ala Pro Gly Thr Ala Arg Asn Gly Asp His Cys Pro Leu 
        595                 600                 605             


Gly Pro Gly Arg Cys Cys Arg Leu His Thr Val Arg Ala Ser Leu Glu 
    610                 615                 620                 


Asp Leu Gly Trp Ala Asp Trp Val Leu Ser Pro Arg Glu Val Gln Val 
625                 630                 635                 640 


Thr Met Cys Ile Gly Ala Cys Pro Ser Gln Phe Arg Ala Ala Asn Met 
                645                 650                 655     


His Ala Gln Ile Lys Thr Ser Leu His Arg Leu Lys Pro Asp Thr Val 
            660                 665                 670         


Pro Ala Pro Cys Cys Val Pro Ala Ser Tyr Asn Pro Met Val Leu Ile 
        675                 680                 685             


Gln Lys Thr Asp Thr Gly Val Ser Leu Gln Thr Tyr Asp Asp Leu Leu 
    690                 695                 700                 


Ala Lys Asp Cys His Cys Ile 
705                 710     


<210>  28
<211>  721
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fusion protein

<400>  28

Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu 
1               5                   10                  15      


Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln 
            20                  25                  30          


Gln Ser Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr Glu 
        35                  40                  45              


Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys 
    50                  55                  60                  


Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu 
65                  70                  75                  80  


Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro 
                85                  90                  95      


Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu 
            100                 105                 110         


Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe His 
        115                 120                 125             


Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg 
    130                 135                 140                 


Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg 
145                 150                 155                 160 


Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala 
                165                 170                 175     


Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser 
            180                 185                 190         


Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu 
        195                 200                 205             


Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro 
    210                 215                 220                 


Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys 
225                 230                 235                 240 


Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp 
                245                 250                 255     


Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser 
            260                 265                 270         


Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His 
        275                 280                 285             


Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser 
    290                 295                 300                 


Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala 
305                 310                 315                 320 


Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg 
                325                 330                 335     


Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys Thr 
            340                 345                 350         


Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His Glu 
        355                 360                 365             


Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro 
    370                 375                 380                 


Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu 
385                 390                 395                 400 


Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro 
                405                 410                 415     


Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly Lys 
            420                 425                 430         


Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys 
        435                 440                 445             


Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu His 
    450                 455                 460                 


Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser 
465                 470                 475                 480 


Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr 
                485                 490                 495     


Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala Asp 
            500                 505                 510         


Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala 
        515                 520                 525             


Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln Leu 
    530                 535                 540                 


Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys Lys 
545                 550                 555                 560 


Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu Val 
                565                 570                 575     


Ala Ala Ser Gln Ala Ala Leu Gly Leu Ala Ser Ala Pro Ala Pro Ala 
            580                 585                 590         


Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Gly 
        595                 600                 605             


Thr Ala Arg Asn Gly Asp His Cys Pro Leu Gly Pro Gly Arg Cys Cys 
    610                 615                 620                 


Arg Leu His Thr Val Arg Ala Ser Leu Glu Asp Leu Gly Trp Ala Asp 
625                 630                 635                 640 


Trp Val Leu Ser Pro Arg Glu Val Gln Val Thr Met Cys Ile Gly Ala 
                645                 650                 655     


Cys Pro Ser Gln Phe Arg Ala Ala Asn Met His Ala Gln Ile Lys Thr 
            660                 665                 670         


Ser Leu His Arg Leu Lys Pro Asp Thr Val Pro Ala Pro Cys Cys Val 
        675                 680                 685             


Pro Ala Ser Tyr Asn Pro Met Val Leu Ile Gln Lys Thr Asp Thr Gly 
    690                 695                 700                 


Val Ser Leu Gln Thr Tyr Asp Asp Leu Leu Ala Lys Asp Cys His Cys 
705                 710                 715                 720 


Ile 
    


<210>  29
<211>  741
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fusion protein

<400>  29

Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu 
1               5                   10                  15      


Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln 
            20                  25                  30          


Gln Ser Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr Glu 
        35                  40                  45              


Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys 
    50                  55                  60                  


Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu 
65                  70                  75                  80  


Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro 
                85                  90                  95      


Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu 
            100                 105                 110         


Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe His 
        115                 120                 125             


Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg 
    130                 135                 140                 


Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg 
145                 150                 155                 160 


Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala 
                165                 170                 175     


Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser 
            180                 185                 190         


Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu 
        195                 200                 205             


Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro 
    210                 215                 220                 


Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys 
225                 230                 235                 240 


Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp 
                245                 250                 255     


Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser 
            260                 265                 270         


Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His 
        275                 280                 285             


Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser 
    290                 295                 300                 


Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala 
305                 310                 315                 320 


Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg 
                325                 330                 335     


Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys Thr 
            340                 345                 350         


Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His Glu 
        355                 360                 365             


Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro 
    370                 375                 380                 


Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu 
385                 390                 395                 400 


Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro 
                405                 410                 415     


Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly Lys 
            420                 425                 430         


Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys 
        435                 440                 445             


Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu His 
    450                 455                 460                 


Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser 
465                 470                 475                 480 


Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr 
                485                 490                 495     


Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala Asp 
            500                 505                 510         


Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala 
        515                 520                 525             


Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln Leu 
    530                 535                 540                 


Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys Lys 
545                 550                 555                 560 


Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu Val 
                565                 570                 575     


Ala Ala Ser Gln Ala Ala Leu Gly Leu Ala Ser Ala Pro Ala Pro Ala 
            580                 585                 590         


Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala 
        595                 600                 605             


Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala 
    610                 615                 620                 


Pro Ala Pro Gly Thr Ala Arg Asn Gly Asp His Cys Pro Leu Gly Pro 
625                 630                 635                 640 


Gly Arg Cys Cys Arg Leu His Thr Val Arg Ala Ser Leu Glu Asp Leu 
                645                 650                 655     


Gly Trp Ala Asp Trp Val Leu Ser Pro Arg Glu Val Gln Val Thr Met 
            660                 665                 670         


Cys Ile Gly Ala Cys Pro Ser Gln Phe Arg Ala Ala Asn Met His Ala 
        675                 680                 685             


Gln Ile Lys Thr Ser Leu His Arg Leu Lys Pro Asp Thr Val Pro Ala 
    690                 695                 700                 


Pro Cys Cys Val Pro Ala Ser Tyr Asn Pro Met Val Leu Ile Gln Lys 
705                 710                 715                 720 


Thr Asp Thr Gly Val Ser Leu Gln Thr Tyr Asp Asp Leu Leu Ala Lys 
                725                 730                 735     


Asp Cys His Cys Ile 
            740     


<210>  30
<211>  721
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fusion protein

<400>  30

Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu 
1               5                   10                  15      


Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln 
            20                  25                  30          


Gln Ser Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr Glu 
        35                  40                  45              


Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys 
    50                  55                  60                  


Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu 
65                  70                  75                  80  


Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro 
                85                  90                  95      


Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu 
            100                 105                 110         


Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe His 
        115                 120                 125             


Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg 
    130                 135                 140                 


Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg 
145                 150                 155                 160 


Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala 
                165                 170                 175     


Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser 
            180                 185                 190         


Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu 
        195                 200                 205             


Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro 
    210                 215                 220                 


Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys 
225                 230                 235                 240 


Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp 
                245                 250                 255     


Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser 
            260                 265                 270         


Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His 
        275                 280                 285             


Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser 
    290                 295                 300                 


Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala 
305                 310                 315                 320 


Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg 
                325                 330                 335     


Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys Thr 
            340                 345                 350         


Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His Glu 
        355                 360                 365             


Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro 
    370                 375                 380                 


Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu 
385                 390                 395                 400 


Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro 
                405                 410                 415     


Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly Lys 
            420                 425                 430         


Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys 
        435                 440                 445             


Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu His 
    450                 455                 460                 


Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser 
465                 470                 475                 480 


Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr 
                485                 490                 495     


Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala Asp 
            500                 505                 510         


Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala 
        515                 520                 525             


Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln Leu 
    530                 535                 540                 


Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys Lys 
545                 550                 555                 560 


Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu Val 
                565                 570                 575     


Ala Ala Ser Gln Ala Ala Leu Gly Leu Ala Ser Glu Ala Ala Ala Lys 
            580                 585                 590         


Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Gly 
        595                 600                 605             


Thr Ala Arg Asn Gly Asp His Cys Pro Leu Gly Pro Gly Arg Cys Cys 
    610                 615                 620                 


Arg Leu His Thr Val Arg Ala Ser Leu Glu Asp Leu Gly Trp Ala Asp 
625                 630                 635                 640 


Trp Val Leu Ser Pro Arg Glu Val Gln Val Thr Met Cys Ile Gly Ala 
                645                 650                 655     


Cys Pro Ser Gln Phe Arg Ala Ala Asn Met His Ala Gln Ile Lys Thr 
            660                 665                 670         


Ser Leu His Arg Leu Lys Pro Asp Thr Val Pro Ala Pro Cys Cys Val 
        675                 680                 685             


Pro Ala Ser Tyr Asn Pro Met Val Leu Ile Gln Lys Thr Asp Thr Gly 
    690                 695                 700                 


Val Ser Leu Gln Thr Tyr Asp Asp Leu Leu Ala Lys Asp Cys His Cys 
705                 710                 715                 720 


Ile 
    


<210>  31
<211>  741
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fusion protein

<400>  31

Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu 
1               5                   10                  15      


Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln 
            20                  25                  30          


Gln Ser Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr Glu 
        35                  40                  45              


Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys 
    50                  55                  60                  


Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu 
65                  70                  75                  80  


Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro 
                85                  90                  95      


Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu 
            100                 105                 110         


Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe His 
        115                 120                 125             


Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg 
    130                 135                 140                 


Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg 
145                 150                 155                 160 


Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala 
                165                 170                 175     


Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser 
            180                 185                 190         


Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu 
        195                 200                 205             


Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro 
    210                 215                 220                 


Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys 
225                 230                 235                 240 


Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp 
                245                 250                 255     


Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser 
            260                 265                 270         


Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His 
        275                 280                 285             


Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser 
    290                 295                 300                 


Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala 
305                 310                 315                 320 


Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg 
                325                 330                 335     


Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys Thr 
            340                 345                 350         


Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His Glu 
        355                 360                 365             


Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro 
    370                 375                 380                 


Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu 
385                 390                 395                 400 


Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro 
                405                 410                 415     


Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly Lys 
            420                 425                 430         


Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys 
        435                 440                 445             


Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu His 
    450                 455                 460                 


Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser 
465                 470                 475                 480 


Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr 
                485                 490                 495     


Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala Asp 
            500                 505                 510         


Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala 
        515                 520                 525             


Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln Leu 
    530                 535                 540                 


Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys Lys 
545                 550                 555                 560 


Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu Val 
                565                 570                 575     


Ala Ala Ser Gln Ala Ala Leu Gly Leu Ala Ser Glu Ala Ala Ala Lys 
            580                 585                 590         


Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu 
        595                 600                 605             


Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala 
    610                 615                 620                 


Ala Ala Lys Gly Thr Ala Arg Asn Gly Asp His Cys Pro Leu Gly Pro 
625                 630                 635                 640 


Gly Arg Cys Cys Arg Leu His Thr Val Arg Ala Ser Leu Glu Asp Leu 
                645                 650                 655     


Gly Trp Ala Asp Trp Val Leu Ser Pro Arg Glu Val Gln Val Thr Met 
            660                 665                 670         


Cys Ile Gly Ala Cys Pro Ser Gln Phe Arg Ala Ala Asn Met His Ala 
        675                 680                 685             


Gln Ile Lys Thr Ser Leu His Arg Leu Lys Pro Asp Thr Val Pro Ala 
    690                 695                 700                 


Pro Cys Cys Val Pro Ala Ser Tyr Asn Pro Met Val Leu Ile Gln Lys 
705                 710                 715                 720 


Thr Asp Thr Gly Val Ser Leu Gln Thr Tyr Asp Asp Leu Leu Ala Lys 
                725                 730                 735     


Asp Cys His Cys Ile 
            740     


<210>  32
<211>  24
<212>  PRT
<213>  Artificial sequence

<220>
<223>  linker

<400>  32

Ala Ser Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala Ala Ala 
1               5                   10                  15      


Lys Glu Ala Ala Ala Lys Gly Thr 
            20                  


<210>  33
<211>  44
<212>  PRT
<213>  Artificial sequence

<220>
<223>  linker

<400>  33

Ala Ser Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala Ala Ala 
1               5                   10                  15      


Lys Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys 
            20                  25                  30          


Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Gly Thr 
        35                  40                  


<210>  34
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  linker

<400>  34

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10  


<210>  35
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  linker

<400>  35

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  36
<211>  706
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fusion protein

<400>  36

Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu 
1               5                   10                  15      


Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln 
            20                  25                  30          


Gln Ser Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr Glu 
        35                  40                  45              


Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys 
    50                  55                  60                  


Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu 
65                  70                  75                  80  


Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro 
                85                  90                  95      


Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu 
            100                 105                 110         


Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe His 
        115                 120                 125             


Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg 
    130                 135                 140                 


Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg 
145                 150                 155                 160 


Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala 
                165                 170                 175     


Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser 
            180                 185                 190         


Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu 
        195                 200                 205             


Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro 
    210                 215                 220                 


Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys 
225                 230                 235                 240 


Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp 
                245                 250                 255     


Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser 
            260                 265                 270         


Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His 
        275                 280                 285             


Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser 
    290                 295                 300                 


Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala 
305                 310                 315                 320 


Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg 
                325                 330                 335     


Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys Thr 
            340                 345                 350         


Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His Glu 
        355                 360                 365             


Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro 
    370                 375                 380                 


Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu 
385                 390                 395                 400 


Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro 
                405                 410                 415     


Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly Lys 
            420                 425                 430         


Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys 
        435                 440                 445             


Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu His 
    450                 455                 460                 


Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser 
465                 470                 475                 480 


Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr 
                485                 490                 495     


Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala Asp 
            500                 505                 510         


Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala 
        515                 520                 525             


Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln Leu 
    530                 535                 540                 


Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys Lys 
545                 550                 555                 560 


Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu Val 
                565                 570                 575     


Ala Ala Ser Gln Ala Ala Leu Gly Leu Gly Ser Gly Gly Gly Gly Ser 
            580                 585                 590         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Cys 
        595                 600                 605             


Ser Arg Leu His Thr Val Arg Ala Ser Leu Glu Asp Leu Gly Trp Ala 
    610                 615                 620                 


Asp Trp Val Leu Ser Pro Arg Glu Val Gln Val Thr Met Cys Ile Gly 
625                 630                 635                 640 


Ala Cys Pro Ser Gln Phe Arg Ala Ala Asn Met His Ala Gln Ile Lys 
                645                 650                 655     


Thr Ser Leu His Arg Leu Lys Pro Asp Thr Val Pro Ala Pro Cys Cys 
            660                 665                 670         


Val Pro Ala Ser Tyr Asn Pro Met Val Leu Ile Gln Lys Thr Asp Thr 
        675                 680                 685             


Gly Val Ser Leu Gln Thr Tyr Asp Asp Leu Leu Ala Lys Asp Cys His 
    690                 695                 700                 


Cys Ile 
705     


<210>  37
<211>  705
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fusion protein

<400>  37

Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu 
1               5                   10                  15      


Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln 
            20                  25                  30          


Gln Ser Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr Glu 
        35                  40                  45              


Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys 
    50                  55                  60                  


Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu 
65                  70                  75                  80  


Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro 
                85                  90                  95      


Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu 
            100                 105                 110         


Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe His 
        115                 120                 125             


Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg 
    130                 135                 140                 


Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg 
145                 150                 155                 160 


Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala 
                165                 170                 175     


Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser 
            180                 185                 190         


Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu 
        195                 200                 205             


Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro 
    210                 215                 220                 


Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys 
225                 230                 235                 240 


Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp 
                245                 250                 255     


Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser 
            260                 265                 270         


Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His 
        275                 280                 285             


Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser 
    290                 295                 300                 


Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala 
305                 310                 315                 320 


Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg 
                325                 330                 335     


Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys Thr 
            340                 345                 350         


Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His Glu 
        355                 360                 365             


Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro 
    370                 375                 380                 


Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu 
385                 390                 395                 400 


Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro 
                405                 410                 415     


Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly Lys 
            420                 425                 430         


Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys 
        435                 440                 445             


Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu His 
    450                 455                 460                 


Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser 
465                 470                 475                 480 


Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr 
                485                 490                 495     


Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala Asp 
            500                 505                 510         


Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala 
        515                 520                 525             


Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln Leu 
    530                 535                 540                 


Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys Lys 
545                 550                 555                 560 


Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu Val 
                565                 570                 575     


Ala Ala Ser Gln Ala Ala Leu Gly Leu Gly Ser Gly Gly Gly Gly Ser 
            580                 585                 590         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Cys 
        595                 600                 605             


Arg Leu His Thr Val Arg Ala Ser Leu Glu Asp Leu Gly Trp Ala Asp 
    610                 615                 620                 


Trp Val Leu Ser Pro Arg Glu Val Gln Val Thr Met Cys Ile Gly Ala 
625                 630                 635                 640 


Cys Pro Ser Gln Phe Arg Ala Ala Asn Met His Ala Gln Ile Lys Thr 
                645                 650                 655     


Ser Leu His Arg Leu Lys Pro Asp Thr Val Pro Ala Pro Cys Cys Val 
            660                 665                 670         


Pro Ala Ser Tyr Asn Pro Met Val Leu Ile Gln Lys Thr Asp Thr Gly 
        675                 680                 685             


Val Ser Leu Gln Thr Tyr Asp Asp Leu Leu Ala Lys Asp Cys His Cys 
    690                 695                 700                 


Ile 
705 


<210>  38
<211>  20
<212>  PRT
<213>  Artificial sequence

<220>
<223>  linker

<400>  38

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser 
            20  


<210>  39
<211>  25
<212>  PRT
<213>  Artificial sequence

<220>
<223>  linker

<400>  39

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            20                  25  


<210>  40
<211>  719
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fusion protein

<400>  40

Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu 
1               5                   10                  15      


Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln 
            20                  25                  30          


Gln Ser Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr Glu 
        35                  40                  45              


Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys 
    50                  55                  60                  


Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu 
65                  70                  75                  80  


Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro 
                85                  90                  95      


Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu 
            100                 105                 110         


Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe His 
        115                 120                 125             


Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg 
    130                 135                 140                 


Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg 
145                 150                 155                 160 


Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala 
                165                 170                 175     


Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser 
            180                 185                 190         


Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu 
        195                 200                 205             


Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro 
    210                 215                 220                 


Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys 
225                 230                 235                 240 


Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp 
                245                 250                 255     


Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser 
            260                 265                 270         


Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His 
        275                 280                 285             


Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser 
    290                 295                 300                 


Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala 
305                 310                 315                 320 


Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg 
                325                 330                 335     


Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys Thr 
            340                 345                 350         


Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His Glu 
        355                 360                 365             


Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro 
    370                 375                 380                 


Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu 
385                 390                 395                 400 


Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro 
                405                 410                 415     


Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly Lys 
            420                 425                 430         


Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys 
        435                 440                 445             


Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu His 
    450                 455                 460                 


Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser 
465                 470                 475                 480 


Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr 
                485                 490                 495     


Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala Asp 
            500                 505                 510         


Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala 
        515                 520                 525             


Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln Leu 
    530                 535                 540                 


Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys Lys 
545                 550                 555                 560 


Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu Val 
                565                 570                 575     


Ala Ala Ser Gln Ala Ala Leu Gly Leu Gly Ser Gly Gly Gly Gly Ser 
            580                 585                 590         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala 
        595                 600                 605             


Arg Asn Gly Asp His Cys Pro Leu Gly Pro Gly Arg Cys Cys Arg Leu 
    610                 615                 620                 


His Thr Val Arg Ala Ser Leu Glu Asp Leu Gly Trp Ala Asp Trp Val 
625                 630                 635                 640 


Leu Ser Pro Arg Glu Val Gln Val Thr Met Cys Ile Gly Ala Cys Pro 
                645                 650                 655     


Ser Gln Phe Arg Ala Ala Asn Met His Ala Gln Ile Lys Thr Ser Leu 
            660                 665                 670         


His Arg Leu Lys Pro Asp Thr Val Pro Ala Pro Cys Cys Val Pro Ala 
        675                 680                 685             


Ser Tyr Asn Pro Met Val Leu Ile Gln Lys Thr Asp Thr Gly Val Ser 
    690                 695                 700                 


Leu Gln Thr Tyr Asp Asp Leu Leu Ala Lys Asp Cys His Cys Ile 
705                 710                 715                 


<210>  41
<211>  30
<212>  PRT
<213>  Artificial sequence

<220>
<223>  linker

<400>  41

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            20                  25                  30  


<210>  42
<211>  35
<212>  PRT
<213>  Artificial sequence

<220>
<223>  linker

<400>  42

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            20                  25                  30          


Gly Gly Ser 
        35  


<210>  43
<211>  40
<212>  PRT
<213>  Artificial sequence

<220>
<223>  linker

<400>  43

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            20                  25                  30          


Gly Gly Ser Gly Gly Gly Gly Ser 
        35                  40  


<210>  44
<211>  45
<212>  PRT
<213>  Artificial sequence

<220>
<223>  linker

<400>  44

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            20                  25                  30          


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        35                  40                  45  


<210>  45
<211>  50
<212>  PRT
<213>  Artificial sequence

<220>
<223>  linker

<400>  45

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            20                  25                  30          


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        35                  40                  45              


Gly Ser 
    50  


<210>  46
<211>  55
<212>  PRT
<213>  Artificial sequence

<220>
<223>  linker

<400>  46

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            20                  25                  30          


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        35                  40                  45              


Gly Ser Gly Gly Gly Gly Ser 
    50                  55  


<210>  47
<211>  60
<212>  PRT
<213>  Artificial sequence

<220>
<223>  linker

<400>  47

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            20                  25                  30          


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        35                  40                  45              


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    50                  55                  60  


<210>  48
<211>  719
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fusion protein

<400>  48

Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu 
1               5                   10                  15      


Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln 
            20                  25                  30          


Gln Ala Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr Glu 
        35                  40                  45              


Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys 
    50                  55                  60                  


Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu 
65                  70                  75                  80  


Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro 
                85                  90                  95      


Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu 
            100                 105                 110         


Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe His 
        115                 120                 125             


Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg 
    130                 135                 140                 


Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg 
145                 150                 155                 160 


Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala 
                165                 170                 175     


Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser 
            180                 185                 190         


Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu 
        195                 200                 205             


Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro 
    210                 215                 220                 


Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys 
225                 230                 235                 240 


Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp 
                245                 250                 255     


Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser 
            260                 265                 270         


Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His 
        275                 280                 285             


Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser 
    290                 295                 300                 


Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala 
305                 310                 315                 320 


Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg 
                325                 330                 335     


Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys Thr 
            340                 345                 350         


Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His Glu 
        355                 360                 365             


Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro 
    370                 375                 380                 


Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu 
385                 390                 395                 400 


Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro 
                405                 410                 415     


Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly Lys 
            420                 425                 430         


Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys 
        435                 440                 445             


Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu His 
    450                 455                 460                 


Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser 
465                 470                 475                 480 


Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr 
                485                 490                 495     


Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala Asp 
            500                 505                 510         


Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala 
        515                 520                 525             


Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln Leu 
    530                 535                 540                 


Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys Lys 
545                 550                 555                 560 


Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu Val 
                565                 570                 575     


Ala Ala Ser Gln Ala Ala Leu Gly Leu Gly Ser Gly Gly Gly Gly Ser 
            580                 585                 590         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala 
        595                 600                 605             


Arg Asn Gly Asp His Cys Pro Leu Gly Pro Gly Arg Cys Cys Arg Leu 
    610                 615                 620                 


His Thr Val Arg Ala Ser Leu Glu Asp Leu Gly Trp Ala Asp Trp Val 
625                 630                 635                 640 


Leu Ser Pro Arg Glu Val Gln Val Thr Met Cys Ile Gly Ala Cys Pro 
                645                 650                 655     


Ser Gln Phe Arg Ala Ala Asn Met His Ala Gln Ile Lys Thr Ser Leu 
            660                 665                 670         


His Arg Leu Lys Pro Asp Thr Val Pro Ala Pro Cys Cys Val Pro Ala 
        675                 680                 685             


Ser Tyr Asn Pro Met Val Leu Ile Gln Lys Thr Asp Thr Gly Val Ser 
    690                 695                 700                 


Leu Gln Thr Tyr Asp Asp Leu Leu Ala Lys Asp Cys His Cys Ile 
705                 710                 715                 


<210>  49
<211>  65
<212>  PRT
<213>  Artificial sequence

<220>
<223>  linker

<400>  49

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            20                  25                  30          


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        35                  40                  45              


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    50                  55                  60                  


Ser 
65  


<210>  50
<211>  70
<212>  PRT
<213>  Artificial sequence

<220>
<223>  linker

<400>  50

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            20                  25                  30          


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        35                  40                  45              


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    50                  55                  60                  


Ser Gly Gly Gly Gly Ser 
65                  70  


<210>  51
<211>  75
<212>  PRT
<213>  Artificial sequence

<220>
<223>  linker

<400>  51

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            20                  25                  30          


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        35                  40                  45              


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    50                  55                  60                  


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
65                  70                  75  


<210>  52
<211>  80
<212>  PRT
<213>  Artificial sequence

<220>
<223>  linker

<400>  52

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            20                  25                  30          


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        35                  40                  45              


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    50                  55                  60                  


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
65                  70                  75                  80  


<210>  53
<211>  85
<212>  PRT
<213>  Artificial sequence

<220>
<223>  linker

<400>  53

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            20                  25                  30          


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        35                  40                  45              


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    50                  55                  60                  


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
65                  70                  75                  80  


Gly Gly Gly Gly Ser 
                85  


<210>  54
<211>  90
<212>  PRT
<213>  Artificial sequence

<220>
<223>  linker

<400>  54

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            20                  25                  30          


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        35                  40                  45              


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    50                  55                  60                  


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
65                  70                  75                  80  


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
                85                  90  


<210>  55
<211>  739
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fusion protein

<400>  55

Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu 
1               5                   10                  15      


Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln 
            20                  25                  30          


Gln Ala Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr Glu 
        35                  40                  45              


Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys 
    50                  55                  60                  


Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu 
65                  70                  75                  80  


Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro 
                85                  90                  95      


Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu 
            100                 105                 110         


Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe His 
        115                 120                 125             


Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg 
    130                 135                 140                 


Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg 
145                 150                 155                 160 


Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala 
                165                 170                 175     


Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser 
            180                 185                 190         


Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu 
        195                 200                 205             


Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro 
    210                 215                 220                 


Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys 
225                 230                 235                 240 


Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp 
                245                 250                 255     


Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser 
            260                 265                 270         


Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His 
        275                 280                 285             


Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser 
    290                 295                 300                 


Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala 
305                 310                 315                 320 


Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg 
                325                 330                 335     


Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys Thr 
            340                 345                 350         


Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His Glu 
        355                 360                 365             


Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro 
    370                 375                 380                 


Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu 
385                 390                 395                 400 


Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro 
                405                 410                 415     


Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly Lys 
            420                 425                 430         


Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys 
        435                 440                 445             


Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu His 
    450                 455                 460                 


Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser 
465                 470                 475                 480 


Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr 
                485                 490                 495     


Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala Asp 
            500                 505                 510         


Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala 
        515                 520                 525             


Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln Leu 
    530                 535                 540                 


Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys Lys 
545                 550                 555                 560 


Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu Val 
                565                 570                 575     


Ala Ala Ser Gln Ala Ala Leu Gly Leu Gly Ser Gly Gly Gly Gly Ser 
            580                 585                 590         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        595                 600                 605             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    610                 615                 620                 


Gly Gly Ser Ala Arg Asn Gly Asp His Cys Pro Leu Gly Pro Gly Arg 
625                 630                 635                 640 


Cys Cys Arg Leu His Thr Val Arg Ala Ser Leu Glu Asp Leu Gly Trp 
                645                 650                 655     


Ala Asp Trp Val Leu Ser Pro Arg Glu Val Gln Val Thr Met Cys Ile 
            660                 665                 670         


Gly Ala Cys Pro Ser Gln Phe Arg Ala Ala Asn Met His Ala Gln Ile 
        675                 680                 685             


Lys Thr Ser Leu His Arg Leu Lys Pro Asp Thr Val Pro Ala Pro Cys 
    690                 695                 700                 


Cys Val Pro Ala Ser Tyr Asn Pro Met Val Leu Ile Gln Lys Thr Asp 
705                 710                 715                 720 


Thr Gly Val Ser Leu Gln Thr Tyr Asp Asp Leu Leu Ala Lys Asp Cys 
                725                 730                 735     


His Cys Ile 
            


<210>  56
<211>  717
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fusion protein

<400>  56

Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu 
1               5                   10                  15      


Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln 
            20                  25                  30          


Gln Ala Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr Glu 
        35                  40                  45              


Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys 
    50                  55                  60                  


Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu 
65                  70                  75                  80  


Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro 
                85                  90                  95      


Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu 
            100                 105                 110         


Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe His 
        115                 120                 125             


Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg 
    130                 135                 140                 


Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg 
145                 150                 155                 160 


Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala 
                165                 170                 175     


Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser 
            180                 185                 190         


Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu 
        195                 200                 205             


Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro 
    210                 215                 220                 


Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys 
225                 230                 235                 240 


Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp 
                245                 250                 255     


Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser 
            260                 265                 270         


Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His 
        275                 280                 285             


Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser 
    290                 295                 300                 


Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala 
305                 310                 315                 320 


Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg 
                325                 330                 335     


Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys Thr 
            340                 345                 350         


Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His Glu 
        355                 360                 365             


Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro 
    370                 375                 380                 


Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu 
385                 390                 395                 400 


Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro 
                405                 410                 415     


Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly Lys 
            420                 425                 430         


Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys 
        435                 440                 445             


Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu His 
    450                 455                 460                 


Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser 
465                 470                 475                 480 


Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr 
                485                 490                 495     


Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala Asp 
            500                 505                 510         


Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala 
        515                 520                 525             


Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln Leu 
    530                 535                 540                 


Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys Lys 
545                 550                 555                 560 


Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu Val 
                565                 570                 575     


Ala Ala Ser Gln Ala Ala Leu Gly Leu Ala Pro Ala Pro Ala Pro Ala 
            580                 585                 590         


Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Arg Asn 
        595                 600                 605             


Gly Asp His Cys Pro Leu Gly Pro Gly Arg Cys Cys Arg Leu His Thr 
    610                 615                 620                 


Val Arg Ala Ser Leu Glu Asp Leu Gly Trp Ala Asp Trp Val Leu Ser 
625                 630                 635                 640 


Pro Arg Glu Val Gln Val Thr Met Cys Ile Gly Ala Cys Pro Ser Gln 
                645                 650                 655     


Phe Arg Ala Ala Asn Met His Ala Gln Ile Lys Thr Ser Leu His Arg 
            660                 665                 670         


Leu Lys Pro Asp Thr Val Pro Ala Pro Cys Cys Val Pro Ala Ser Tyr 
        675                 680                 685             


Asn Pro Met Val Leu Ile Gln Lys Thr Asp Thr Gly Val Ser Leu Gln 
    690                 695                 700                 


Thr Tyr Asp Asp Leu Leu Ala Lys Asp Cys His Cys Ile 
705                 710                 715         


<210>  57
<211>  719
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fusion protein

<400>  57

Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu 
1               5                   10                  15      


Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln 
            20                  25                  30          


Gln Ser Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr Glu 
        35                  40                  45              


Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys 
    50                  55                  60                  


Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu 
65                  70                  75                  80  


Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro 
                85                  90                  95      


Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu 
            100                 105                 110         


Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe His 
        115                 120                 125             


Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg 
    130                 135                 140                 


Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg 
145                 150                 155                 160 


Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala 
                165                 170                 175     


Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser 
            180                 185                 190         


Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu 
        195                 200                 205             


Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro 
    210                 215                 220                 


Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys 
225                 230                 235                 240 


Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp 
                245                 250                 255     


Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser 
            260                 265                 270         


Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His 
        275                 280                 285             


Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser 
    290                 295                 300                 


Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala 
305                 310                 315                 320 


Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg 
                325                 330                 335     


Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys Thr 
            340                 345                 350         


Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His Glu 
        355                 360                 365             


Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro 
    370                 375                 380                 


Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu 
385                 390                 395                 400 


Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro 
                405                 410                 415     


Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly Lys 
            420                 425                 430         


Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys 
        435                 440                 445             


Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu His 
    450                 455                 460                 


Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser 
465                 470                 475                 480 


Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr 
                485                 490                 495     


Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala Asp 
            500                 505                 510         


Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala 
        515                 520                 525             


Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln Leu 
    530                 535                 540                 


Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys Lys 
545                 550                 555                 560 


Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu Val 
                565                 570                 575     


Ala Ala Ser Gln Ala Ala Leu Gly Leu Gly Ser Gly Gly Gly Gly Ser 
            580                 585                 590         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala 
        595                 600                 605             


Arg Asn Gly Asp His Cys Pro Leu Gly Pro Gly Arg Cys Cys Arg Leu 
    610                 615                 620                 


His Thr Val Arg Ala Ser Leu Glu Asp Leu Gly Trp Ala Asp Trp Val 
625                 630                 635                 640 


Leu Ser Pro Arg Glu Val Gln Val Thr Met Cys Ile Gly Ala Cys Pro 
                645                 650                 655     


Ser Gln Phe Arg Ala Ala Asn Met His Ala Gln Ile Lys Thr Ser Leu 
            660                 665                 670         


His Arg Leu Lys Pro Asp Thr Val Pro Ala Pro Cys Cys Val Pro Ala 
        675                 680                 685             


Ser Tyr Asn Pro Met Val Leu Ile Gln Lys Thr Asp Thr Gly Val Ser 
    690                 695                 700                 


Leu Gln Thr Tyr Asp Asp Leu Leu Ala Lys Asp Cys His Cys Ile 
705                 710                 715                 


<210>  58
<211>  719
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fusion protein

<400>  58

Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu 
1               5                   10                  15      


Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln 
            20                  25                  30          


Gln Ala Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr Glu 
        35                  40                  45              


Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys 
    50                  55                  60                  


Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu 
65                  70                  75                  80  


Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro 
                85                  90                  95      


Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu 
            100                 105                 110         


Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe His 
        115                 120                 125             


Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg 
    130                 135                 140                 


Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg 
145                 150                 155                 160 


Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala 
                165                 170                 175     


Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser 
            180                 185                 190         


Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu 
        195                 200                 205             


Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro 
    210                 215                 220                 


Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys 
225                 230                 235                 240 


Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp 
                245                 250                 255     


Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser 
            260                 265                 270         


Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His 
        275                 280                 285             


Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser 
    290                 295                 300                 


Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala 
305                 310                 315                 320 


Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg 
                325                 330                 335     


Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys Thr 
            340                 345                 350         


Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His Glu 
        355                 360                 365             


Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro 
    370                 375                 380                 


Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu 
385                 390                 395                 400 


Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro 
                405                 410                 415     


Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly Lys 
            420                 425                 430         


Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys 
        435                 440                 445             


Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu His 
    450                 455                 460                 


Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser 
465                 470                 475                 480 


Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr 
                485                 490                 495     


Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala Asp 
            500                 505                 510         


Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala 
        515                 520                 525             


Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln Leu 
    530                 535                 540                 


Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys Lys 
545                 550                 555                 560 


Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu Val 
                565                 570                 575     


Ala Ala Ser Gln Ala Ala Leu Gly Leu Gly Ser Gly Gly Gly Gly Ser 
            580                 585                 590         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala 
        595                 600                 605             


Arg Asn Gly Asp His Cys Pro Leu Gly Pro Gly Arg Cys Cys Arg Leu 
    610                 615                 620                 


His Thr Val Arg Ala Ser Leu Glu Asp Leu Gly Trp Ala Asp Trp Val 
625                 630                 635                 640 


Leu Ser Pro Arg Glu Val Gln Val Thr Met Cys Ile Gly Ala Cys Pro 
                645                 650                 655     


Ser Gln Phe Arg Ala Ala Asn Met His Ala Gln Ile Lys Thr Ser Leu 
            660                 665                 670         


His Arg Leu Lys Pro Asp Thr Val Pro Ala Pro Cys Cys Val Pro Ala 
        675                 680                 685             


Ser Tyr Asn Pro Met Val Leu Ile Gln Lys Thr Asp Thr Gly Val Ser 
    690                 695                 700                 


Leu Gln Thr Tyr Asp Asp Leu Leu Ala Lys Asp Cys His Cys Ile 
705                 710                 715                 


<210>  59
<211>  717
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fusion protein

<400>  59

Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu 
1               5                   10                  15      


Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln 
            20                  25                  30          


Gln Ser Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr Glu 
        35                  40                  45              


Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys 
    50                  55                  60                  


Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu 
65                  70                  75                  80  


Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro 
                85                  90                  95      


Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu 
            100                 105                 110         


Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe His 
        115                 120                 125             


Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg 
    130                 135                 140                 


Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg 
145                 150                 155                 160 


Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala 
                165                 170                 175     


Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser 
            180                 185                 190         


Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu 
        195                 200                 205             


Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro 
    210                 215                 220                 


Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys 
225                 230                 235                 240 


Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp 
                245                 250                 255     


Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser 
            260                 265                 270         


Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His 
        275                 280                 285             


Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser 
    290                 295                 300                 


Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala 
305                 310                 315                 320 


Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg 
                325                 330                 335     


Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys Thr 
            340                 345                 350         


Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His Glu 
        355                 360                 365             


Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro 
    370                 375                 380                 


Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu 
385                 390                 395                 400 


Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro 
                405                 410                 415     


Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly Lys 
            420                 425                 430         


Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys 
        435                 440                 445             


Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu His 
    450                 455                 460                 


Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser 
465                 470                 475                 480 


Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr 
                485                 490                 495     


Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala Asp 
            500                 505                 510         


Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala 
        515                 520                 525             


Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln Leu 
    530                 535                 540                 


Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys Lys 
545                 550                 555                 560 


Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu Val 
                565                 570                 575     


Ala Ala Ser Gln Ala Ala Leu Gly Leu Ala Pro Ala Pro Ala Pro Ala 
            580                 585                 590         


Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Arg Asn 
        595                 600                 605             


Gly Asp His Cys Pro Leu Gly Pro Gly Arg Cys Cys Arg Leu His Thr 
    610                 615                 620                 


Val Arg Ala Ser Leu Glu Asp Leu Gly Trp Ala Asp Trp Val Leu Ser 
625                 630                 635                 640 


Pro Arg Glu Val Gln Val Thr Met Cys Ile Gly Ala Cys Pro Ser Gln 
                645                 650                 655     


Phe Arg Ala Ala Asn Met His Ala Gln Ile Lys Thr Ser Leu His Arg 
            660                 665                 670         


Leu Lys Pro Asp Thr Val Pro Ala Pro Cys Cys Val Pro Ala Ser Tyr 
        675                 680                 685             


Asn Pro Met Val Leu Ile Gln Lys Thr Asp Thr Gly Val Ser Leu Gln 
    690                 695                 700                 


Thr Tyr Asp Asp Leu Leu Ala Lys Asp Cys His Cys Ile 
705                 710                 715         


<210>  60
<211>  739
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fusion protein

<400>  60

Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu 
1               5                   10                  15      


Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln 
            20                  25                  30          


Gln Ser Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr Glu 
        35                  40                  45              


Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys 
    50                  55                  60                  


Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu 
65                  70                  75                  80  


Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro 
                85                  90                  95      


Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu 
            100                 105                 110         


Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe His 
        115                 120                 125             


Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg 
    130                 135                 140                 


Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg 
145                 150                 155                 160 


Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala 
                165                 170                 175     


Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser 
            180                 185                 190         


Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu 
        195                 200                 205             


Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro 
    210                 215                 220                 


Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys 
225                 230                 235                 240 


Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp 
                245                 250                 255     


Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser 
            260                 265                 270         


Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His 
        275                 280                 285             


Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser 
    290                 295                 300                 


Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala 
305                 310                 315                 320 


Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg 
                325                 330                 335     


Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys Thr 
            340                 345                 350         


Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His Glu 
        355                 360                 365             


Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro 
    370                 375                 380                 


Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu 
385                 390                 395                 400 


Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro 
                405                 410                 415     


Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly Lys 
            420                 425                 430         


Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys 
        435                 440                 445             


Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu His 
    450                 455                 460                 


Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser 
465                 470                 475                 480 


Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr 
                485                 490                 495     


Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala Asp 
            500                 505                 510         


Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala 
        515                 520                 525             


Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln Leu 
    530                 535                 540                 


Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys Lys 
545                 550                 555                 560 


Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu Val 
                565                 570                 575     


Ala Ala Ser Gln Ala Ala Leu Gly Leu Gly Ser Gly Gly Gly Gly Ser 
            580                 585                 590         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        595                 600                 605             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    610                 615                 620                 


Gly Gly Ser Ala Arg Asn Gly Asp His Cys Pro Leu Gly Pro Gly Arg 
625                 630                 635                 640 


Cys Cys Arg Leu His Thr Val Arg Ala Ser Leu Glu Asp Leu Gly Trp 
                645                 650                 655     


Ala Asp Trp Val Leu Ser Pro Arg Glu Val Gln Val Thr Met Cys Ile 
            660                 665                 670         


Gly Ala Cys Pro Ser Gln Phe Arg Ala Ala Asn Met His Ala Gln Ile 
        675                 680                 685             


Lys Thr Ser Leu His Arg Leu Lys Pro Asp Thr Val Pro Ala Pro Cys 
    690                 695                 700                 


Cys Val Pro Ala Ser Tyr Asn Pro Met Val Leu Ile Gln Lys Thr Asp 
705                 710                 715                 720 


Thr Gly Val Ser Leu Gln Thr Tyr Asp Asp Leu Leu Ala Lys Asp Cys 
                725                 730                 735     


His Cys Ile 
            


<210>  61
<211>  95
<212>  PRT
<213>  Artificial sequence

<220>
<223>  linker

<400>  61

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            20                  25                  30          


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        35                  40                  45              


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    50                  55                  60                  


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
65                  70                  75                  80  


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
                85                  90                  95  


<210>  62
<211>  100
<212>  PRT
<213>  Artificial sequence

<220>
<223>  linker

<400>  62

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            20                  25                  30          


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        35                  40                  45              


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    50                  55                  60                  


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
65                  70                  75                  80  


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
                85                  90                  95      


Gly Gly Gly Ser 
            100 


<210>  63
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  linker

<400>  63

Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys 
1               5                   10  


<210>  64
<211>  719
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fusion protein

<400>  64

Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu 
1               5                   10                  15      


Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln 
            20                  25                  30          


Gln Ser Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr Glu 
        35                  40                  45              


Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys 
    50                  55                  60                  


Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu 
65                  70                  75                  80  


Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro 
                85                  90                  95      


Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu 
            100                 105                 110         


Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe His 
        115                 120                 125             


Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg 
    130                 135                 140                 


Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg 
145                 150                 155                 160 


Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala 
                165                 170                 175     


Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser 
            180                 185                 190         


Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu 
        195                 200                 205             


Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro 
    210                 215                 220                 


Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys 
225                 230                 235                 240 


Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp 
                245                 250                 255     


Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser 
            260                 265                 270         


Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His 
        275                 280                 285             


Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser 
    290                 295                 300                 


Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala 
305                 310                 315                 320 


Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg 
                325                 330                 335     


Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys Thr 
            340                 345                 350         


Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His Glu 
        355                 360                 365             


Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro 
    370                 375                 380                 


Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu 
385                 390                 395                 400 


Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro 
                405                 410                 415     


Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly Lys 
            420                 425                 430         


Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys 
        435                 440                 445             


Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu His 
    450                 455                 460                 


Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser 
465                 470                 475                 480 


Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr 
                485                 490                 495     


Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala Asp 
            500                 505                 510         


Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala 
        515                 520                 525             


Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln Leu 
    530                 535                 540                 


Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys Lys 
545                 550                 555                 560 


Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu Val 
                565                 570                 575     


Ala Ala Ser Gln Ala Ala Leu Gly Leu Gly Ser Gly Gly Gly Gly Ser 
            580                 585                 590         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala 
        595                 600                 605             


Arg Asn Gly Asp His Cys Pro Leu Gly Pro Gly Arg Cys Cys Arg Leu 
    610                 615                 620                 


His Thr Val Arg Ala Ser Leu Glu Asp Leu Gly Trp Ala Asp Trp Val 
625                 630                 635                 640 


Leu Ser Pro Arg Glu Val Gln Val Thr Met Cys Ile Gly Ala Cys Pro 
                645                 650                 655     


Ser Gln Phe Arg Ala Ala Asn Met His Ala Gln Ile Lys Thr Ser Leu 
            660                 665                 670         


His Arg Leu Lys Pro Asp Thr Val Pro Ala Pro Cys Cys Val Pro Ala 
        675                 680                 685             


Ser Tyr Asn Pro Met Val Leu Arg Gln Lys Thr Asp Thr Gly Val Ser 
    690                 695                 700                 


Leu Gln Thr Tyr Asp Asp Leu Leu Ala Lys Asp Cys His Cys Ile 
705                 710                 715                 


<210>  65
<211>  719
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fusion protein

<400>  65

Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu 
1               5                   10                  15      


Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln 
            20                  25                  30          


Gln Ser Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr Glu 
        35                  40                  45              


Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys 
    50                  55                  60                  


Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu 
65                  70                  75                  80  


Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro 
                85                  90                  95      


Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu 
            100                 105                 110         


Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe His 
        115                 120                 125             


Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg 
    130                 135                 140                 


Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg 
145                 150                 155                 160 


Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala 
                165                 170                 175     


Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser 
            180                 185                 190         


Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu 
        195                 200                 205             


Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro 
    210                 215                 220                 


Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys 
225                 230                 235                 240 


Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp 
                245                 250                 255     


Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser 
            260                 265                 270         


Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His 
        275                 280                 285             


Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser 
    290                 295                 300                 


Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala 
305                 310                 315                 320 


Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg 
                325                 330                 335     


Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys Thr 
            340                 345                 350         


Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His Glu 
        355                 360                 365             


Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro 
    370                 375                 380                 


Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu 
385                 390                 395                 400 


Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro 
                405                 410                 415     


Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly Lys 
            420                 425                 430         


Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys 
        435                 440                 445             


Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu His 
    450                 455                 460                 


Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser 
465                 470                 475                 480 


Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr 
                485                 490                 495     


Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala Asp 
            500                 505                 510         


Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala 
        515                 520                 525             


Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln Leu 
    530                 535                 540                 


Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys Lys 
545                 550                 555                 560 


Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu Val 
                565                 570                 575     


Ala Ala Ser Gln Ala Ala Leu Gly Leu Gly Ser Gly Gly Gly Gly Ser 
            580                 585                 590         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala 
        595                 600                 605             


Arg Asn Gly Asp His Cys Pro Leu Gly Pro Gly Arg Cys Cys Arg Leu 
    610                 615                 620                 


His Thr Val Arg Ala Ser Leu Glu Asp Leu Gly Trp Ala Asp Trp Val 
625                 630                 635                 640 


Leu Ser Pro Arg Glu Val Gln Val Thr Met Cys Ile Gly Ala Cys Pro 
                645                 650                 655     


Ser Gln Phe Arg Ala Ala Asn Met His Ala Gln Ile Lys Thr Ser Leu 
            660                 665                 670         


His Arg Leu Lys Pro Asp Thr Val Pro Ala Pro Cys Cys Val Pro Ala 
        675                 680                 685             


Ser Tyr Asn Pro Met Val Leu Trp Gln Lys Thr Asp Thr Gly Val Ser 
    690                 695                 700                 


Leu Gln Thr Tyr Asp Asp Leu Leu Ala Lys Asp Cys His Cys Ile 
705                 710                 715                 


<210>  66
<211>  719
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fusion protein

<400>  66

Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu 
1               5                   10                  15      


Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln 
            20                  25                  30          


Gln Ser Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr Glu 
        35                  40                  45              


Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys 
    50                  55                  60                  


Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu 
65                  70                  75                  80  


Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro 
                85                  90                  95      


Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu 
            100                 105                 110         


Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe His 
        115                 120                 125             


Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg 
    130                 135                 140                 


Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg 
145                 150                 155                 160 


Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala 
                165                 170                 175     


Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser 
            180                 185                 190         


Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu 
        195                 200                 205             


Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro 
    210                 215                 220                 


Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys 
225                 230                 235                 240 


Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp 
                245                 250                 255     


Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser 
            260                 265                 270         


Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His 
        275                 280                 285             


Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser 
    290                 295                 300                 


Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala 
305                 310                 315                 320 


Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg 
                325                 330                 335     


Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys Thr 
            340                 345                 350         


Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His Glu 
        355                 360                 365             


Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro 
    370                 375                 380                 


Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu 
385                 390                 395                 400 


Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro 
                405                 410                 415     


Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly Lys 
            420                 425                 430         


Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys 
        435                 440                 445             


Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu His 
    450                 455                 460                 


Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser 
465                 470                 475                 480 


Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr 
                485                 490                 495     


Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala Asp 
            500                 505                 510         


Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala 
        515                 520                 525             


Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln Leu 
    530                 535                 540                 


Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys Lys 
545                 550                 555                 560 


Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu Val 
                565                 570                 575     


Ala Ala Ser Gln Ala Ala Leu Gly Leu Gly Ser Gly Gly Gly Gly Ser 
            580                 585                 590         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala 
        595                 600                 605             


Arg Asn Gly Asp His Cys Pro Leu Gly Pro Gly Arg Cys Cys Arg Leu 
    610                 615                 620                 


His Thr Val Arg Ala Ser Leu Glu Asp Leu Gly Trp Ala Asp Trp Val 
625                 630                 635                 640 


Ala Ala Pro Ala Glu Val Gln Val Thr Met Cys Ile Gly Ala Cys Pro 
                645                 650                 655     


Ser Gln Phe Arg Ala Ala Asn Met His Ala Gln Ile Lys Thr Ser Leu 
            660                 665                 670         


His Arg Leu Lys Pro Asp Thr Val Pro Ala Pro Cys Cys Val Pro Ala 
        675                 680                 685             


Ser Tyr Asn Pro Met Val Leu Ile Gln Lys Thr Asp Thr Gly Val Ser 
    690                 695                 700                 


Leu Gln Thr Tyr Asp Asp Leu Leu Ala Lys Asp Cys His Cys Ile 
705                 710                 715                 


<210>  67
<211>  719
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fusion protein

<400>  67

Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu 
1               5                   10                  15      


Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln 
            20                  25                  30          


Gln Ser Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr Glu 
        35                  40                  45              


Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys 
    50                  55                  60                  


Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu 
65                  70                  75                  80  


Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro 
                85                  90                  95      


Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu 
            100                 105                 110         


Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe His 
        115                 120                 125             


Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg 
    130                 135                 140                 


Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg 
145                 150                 155                 160 


Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala 
                165                 170                 175     


Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser 
            180                 185                 190         


Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu 
        195                 200                 205             


Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro 
    210                 215                 220                 


Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys 
225                 230                 235                 240 


Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp 
                245                 250                 255     


Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser 
            260                 265                 270         


Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His 
        275                 280                 285             


Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser 
    290                 295                 300                 


Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala 
305                 310                 315                 320 


Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg 
                325                 330                 335     


Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys Thr 
            340                 345                 350         


Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His Glu 
        355                 360                 365             


Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro 
    370                 375                 380                 


Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu 
385                 390                 395                 400 


Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro 
                405                 410                 415     


Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly Lys 
            420                 425                 430         


Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys 
        435                 440                 445             


Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu His 
    450                 455                 460                 


Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser 
465                 470                 475                 480 


Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr 
                485                 490                 495     


Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala Asp 
            500                 505                 510         


Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala 
        515                 520                 525             


Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln Leu 
    530                 535                 540                 


Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys Lys 
545                 550                 555                 560 


Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu Val 
                565                 570                 575     


Ala Ala Ser Gln Ala Ala Leu Gly Leu Gly Ser Gly Gly Gly Gly Ser 
            580                 585                 590         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala 
        595                 600                 605             


Arg Asn Gly Asp His Cys Pro Leu Gly Pro Gly Arg Cys Cys Arg Leu 
    610                 615                 620                 


His Thr Val Arg Ala Ser Leu Glu Asp Leu Gly Trp Ala Asp Trp Val 
625                 630                 635                 640 


Leu Ser Pro Arg Glu Val Gln Val Thr Met Cys Ile Gly Ala Cys Pro 
                645                 650                 655     


Ser Gln Phe Arg Ala Ala Asn Met His Ala Gln Ile Lys Thr Ser Leu 
            660                 665                 670         


His Arg Leu Lys Pro Asp Thr Val Pro Ala Pro Cys Cys Val Pro Ala 
        675                 680                 685             


Ser Tyr Asn Pro Met Ala Leu Ala Gln Lys Thr Asp Thr Gly Val Ser 
    690                 695                 700                 


Ala Gln Thr Tyr Asp Asp Leu Leu Ala Lys Asp Cys His Cys Ile 
705                 710                 715                 


<210>  68
<211>  719
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fusion protein

<400>  68

Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu 
1               5                   10                  15      


Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln 
            20                  25                  30          


Gln Ser Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr Glu 
        35                  40                  45              


Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys 
    50                  55                  60                  


Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu 
65                  70                  75                  80  


Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro 
                85                  90                  95      


Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu 
            100                 105                 110         


Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe His 
        115                 120                 125             


Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg 
    130                 135                 140                 


Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg 
145                 150                 155                 160 


Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala 
                165                 170                 175     


Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser 
            180                 185                 190         


Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu 
        195                 200                 205             


Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro 
    210                 215                 220                 


Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys 
225                 230                 235                 240 


Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp 
                245                 250                 255     


Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser 
            260                 265                 270         


Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His 
        275                 280                 285             


Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser 
    290                 295                 300                 


Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala 
305                 310                 315                 320 


Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg 
                325                 330                 335     


Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys Thr 
            340                 345                 350         


Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His Glu 
        355                 360                 365             


Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro 
    370                 375                 380                 


Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu 
385                 390                 395                 400 


Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro 
                405                 410                 415     


Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly Lys 
            420                 425                 430         


Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys 
        435                 440                 445             


Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu His 
    450                 455                 460                 


Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser 
465                 470                 475                 480 


Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr 
                485                 490                 495     


Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala Asp 
            500                 505                 510         


Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala 
        515                 520                 525             


Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln Leu 
    530                 535                 540                 


Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys Lys 
545                 550                 555                 560 


Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu Val 
                565                 570                 575     


Ala Ala Ser Gln Ala Ala Leu Gly Leu Gly Ser Gly Gly Gly Gly Ser 
            580                 585                 590         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala 
        595                 600                 605             


Arg Asn Gly Asp His Cys Pro Leu Gly Pro Gly Arg Cys Cys Arg Leu 
    610                 615                 620                 


His Thr Val Arg Ala Ser Leu Glu Asp Leu Gly Trp Ala Asp Trp Val 
625                 630                 635                 640 


Ala Ala Pro Arg Glu Val Gln Val Thr Met Cys Ile Gly Ala Cys Pro 
                645                 650                 655     


Ser Gln Phe Arg Ala Ala Asn Met His Ala Gln Ile Lys Thr Ser Leu 
            660                 665                 670         


His Arg Leu Lys Pro Asp Thr Val Pro Ala Pro Cys Cys Val Pro Ala 
        675                 680                 685             


Ser Tyr Asn Pro Met Val Leu Ala Gln Lys Thr Asp Thr Gly Val Ser 
    690                 695                 700                 


Leu Gln Thr Tyr Asp Asp Leu Leu Ala Lys Asp Cys His Cys Ile 
705                 710                 715                 


<210>  69
<211>  719
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fusion protein

<400>  69

Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu 
1               5                   10                  15      


Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln 
            20                  25                  30          


Gln Ser Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr Glu 
        35                  40                  45              


Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys 
    50                  55                  60                  


Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu 
65                  70                  75                  80  


Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro 
                85                  90                  95      


Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu 
            100                 105                 110         


Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe His 
        115                 120                 125             


Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg 
    130                 135                 140                 


Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg 
145                 150                 155                 160 


Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala 
                165                 170                 175     


Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser 
            180                 185                 190         


Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu 
        195                 200                 205             


Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro 
    210                 215                 220                 


Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys 
225                 230                 235                 240 


Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp 
                245                 250                 255     


Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser 
            260                 265                 270         


Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His 
        275                 280                 285             


Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser 
    290                 295                 300                 


Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala 
305                 310                 315                 320 


Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg 
                325                 330                 335     


Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys Thr 
            340                 345                 350         


Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His Glu 
        355                 360                 365             


Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro 
    370                 375                 380                 


Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu 
385                 390                 395                 400 


Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro 
                405                 410                 415     


Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly Lys 
            420                 425                 430         


Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys 
        435                 440                 445             


Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu His 
    450                 455                 460                 


Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser 
465                 470                 475                 480 


Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr 
                485                 490                 495     


Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala Asp 
            500                 505                 510         


Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala 
        515                 520                 525             


Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln Leu 
    530                 535                 540                 


Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys Lys 
545                 550                 555                 560 


Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu Val 
                565                 570                 575     


Ala Ala Ser Gln Ala Ala Leu Gly Leu Gly Ser Gly Gly Gly Gly Ser 
            580                 585                 590         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala 
        595                 600                 605             


Arg Asn Gly Asp His Cys Pro Leu Gly Pro Gly Arg Cys Cys Arg Leu 
    610                 615                 620                 


His Thr Val Arg Ala Ser Leu Glu Asp Leu Gly Trp Ala Asp Trp Val 
625                 630                 635                 640 


Leu Ser Pro Arg Glu Val Gln Val Thr Met Cys Ile Gly Ala Cys Pro 
                645                 650                 655     


Ser Gln Phe Arg Ala Ala Asn Met His Ala Gln Ile Lys Thr Ser Leu 
            660                 665                 670         


His Arg Leu Lys Pro Asp Thr Val Pro Ala Pro Cys Cys Val Pro Ala 
        675                 680                 685             


Ser Tyr Asn Pro Met Ala Leu Ala Gln Lys Thr Asp Thr Gly Val Ser 
    690                 695                 700                 


Leu Gln Thr Tyr Asp Asp Leu Leu Ala Lys Asp Cys His Cys Ile 
705                 710                 715                 


<210>  70
<211>  719
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fusion protein

<400>  70

Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu 
1               5                   10                  15      


Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln 
            20                  25                  30          


Gln Ser Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr Glu 
        35                  40                  45              


Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys 
    50                  55                  60                  


Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu 
65                  70                  75                  80  


Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro 
                85                  90                  95      


Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu 
            100                 105                 110         


Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe His 
        115                 120                 125             


Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg 
    130                 135                 140                 


Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg 
145                 150                 155                 160 


Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala 
                165                 170                 175     


Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser 
            180                 185                 190         


Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu 
        195                 200                 205             


Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro 
    210                 215                 220                 


Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys 
225                 230                 235                 240 


Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp 
                245                 250                 255     


Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser 
            260                 265                 270         


Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His 
        275                 280                 285             


Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser 
    290                 295                 300                 


Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala 
305                 310                 315                 320 


Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg 
                325                 330                 335     


Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys Thr 
            340                 345                 350         


Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His Glu 
        355                 360                 365             


Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro 
    370                 375                 380                 


Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu 
385                 390                 395                 400 


Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro 
                405                 410                 415     


Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly Lys 
            420                 425                 430         


Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys 
        435                 440                 445             


Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu His 
    450                 455                 460                 


Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser 
465                 470                 475                 480 


Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr 
                485                 490                 495     


Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala Asp 
            500                 505                 510         


Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala 
        515                 520                 525             


Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln Leu 
    530                 535                 540                 


Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys Lys 
545                 550                 555                 560 


Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu Val 
                565                 570                 575     


Ala Ala Ser Gln Ala Ala Leu Gly Leu Gly Ser Gly Gly Gly Gly Ser 
            580                 585                 590         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala 
        595                 600                 605             


Arg Asn Gly Asp His Cys Pro Leu Gly Pro Gly Arg Cys Cys Arg Leu 
    610                 615                 620                 


His Thr Val Arg Ala Ser Leu Glu Asp Leu Gly Trp Ala Asp Trp Val 
625                 630                 635                 640 


Leu Ser Pro Arg Glu Val Gln Val Thr Met Cys Ile Gly Ala Cys Pro 
                645                 650                 655     


Ser Gln Phe Arg Ala Ala Asn Met His Ala Trp Ile Lys Thr Ser Leu 
            660                 665                 670         


His Arg Leu Lys Pro Asp Thr Val Pro Ala Pro Cys Cys Val Pro Ala 
        675                 680                 685             


Ser Tyr Asn Pro Met Val Leu Ile Gln Lys Thr Asp Thr Gly Val Ser 
    690                 695                 700                 


Leu Gln Thr Tyr Asp Asp Leu Leu Ala Lys Asp Cys His Cys Ile 
705                 710                 715                 


<210>  71
<211>  719
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fusion protein

<400>  71

Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu 
1               5                   10                  15      


Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln 
            20                  25                  30          


Gln Ser Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr Glu 
        35                  40                  45              


Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys 
    50                  55                  60                  


Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu 
65                  70                  75                  80  


Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro 
                85                  90                  95      


Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu 
            100                 105                 110         


Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe His 
        115                 120                 125             


Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg 
    130                 135                 140                 


Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg 
145                 150                 155                 160 


Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala 
                165                 170                 175     


Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser 
            180                 185                 190         


Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu 
        195                 200                 205             


Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro 
    210                 215                 220                 


Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys 
225                 230                 235                 240 


Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp 
                245                 250                 255     


Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser 
            260                 265                 270         


Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His 
        275                 280                 285             


Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser 
    290                 295                 300                 


Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala 
305                 310                 315                 320 


Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg 
                325                 330                 335     


Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys Thr 
            340                 345                 350         


Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His Glu 
        355                 360                 365             


Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro 
    370                 375                 380                 


Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu 
385                 390                 395                 400 


Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro 
                405                 410                 415     


Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly Lys 
            420                 425                 430         


Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys 
        435                 440                 445             


Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu His 
    450                 455                 460                 


Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser 
465                 470                 475                 480 


Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr 
                485                 490                 495     


Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala Asp 
            500                 505                 510         


Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala 
        515                 520                 525             


Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln Leu 
    530                 535                 540                 


Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys Lys 
545                 550                 555                 560 


Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu Val 
                565                 570                 575     


Ala Ala Ser Gln Ala Ala Leu Gly Leu Gly Ser Gly Gly Gly Gly Ser 
            580                 585                 590         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala 
        595                 600                 605             


Arg Asn Gly Asp His Cys Pro Leu Gly Pro Gly Arg Cys Cys Arg Leu 
    610                 615                 620                 


His Thr Val Arg Ala Ser Leu Glu Asp Leu Gly Trp Ala Asp Ala Val 
625                 630                 635                 640 


Leu Ser Pro Arg Glu Val Gln Val Thr Met Cys Ile Gly Ala Cys Pro 
                645                 650                 655     


Ser Gln Phe Arg Ala Ala Asn Met His Ala Gln Ile Lys Thr Ser Leu 
            660                 665                 670         


His Arg Leu Lys Pro Asp Thr Val Pro Ala Pro Cys Cys Val Pro Ala 
        675                 680                 685             


Ser Tyr Asn Pro Met Val Leu Ile Gln Lys Thr Asp Thr Gly Val Ser 
    690                 695                 700                 


Leu Gln Thr Tyr Asp Asp Leu Leu Ala Lys Asp Cys His Cys Ile 
705                 710                 715                 


<210>  72
<211>  719
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fusion protein

<400>  72

Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu 
1               5                   10                  15      


Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln 
            20                  25                  30          


Gln Ser Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr Glu 
        35                  40                  45              


Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys 
    50                  55                  60                  


Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu 
65                  70                  75                  80  


Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro 
                85                  90                  95      


Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu 
            100                 105                 110         


Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe His 
        115                 120                 125             


Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg 
    130                 135                 140                 


Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg 
145                 150                 155                 160 


Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala 
                165                 170                 175     


Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser 
            180                 185                 190         


Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu 
        195                 200                 205             


Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro 
    210                 215                 220                 


Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys 
225                 230                 235                 240 


Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp 
                245                 250                 255     


Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser 
            260                 265                 270         


Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His 
        275                 280                 285             


Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser 
    290                 295                 300                 


Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala 
305                 310                 315                 320 


Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg 
                325                 330                 335     


Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys Thr 
            340                 345                 350         


Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His Glu 
        355                 360                 365             


Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro 
    370                 375                 380                 


Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu 
385                 390                 395                 400 


Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro 
                405                 410                 415     


Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly Lys 
            420                 425                 430         


Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys 
        435                 440                 445             


Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu His 
    450                 455                 460                 


Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser 
465                 470                 475                 480 


Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr 
                485                 490                 495     


Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala Asp 
            500                 505                 510         


Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala 
        515                 520                 525             


Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln Leu 
    530                 535                 540                 


Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys Lys 
545                 550                 555                 560 


Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu Val 
                565                 570                 575     


Ala Ala Ser Gln Ala Ala Leu Gly Leu Gly Ser Gly Gly Gly Gly Ser 
            580                 585                 590         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala 
        595                 600                 605             


Arg Asn Gly Asp His Cys Pro Leu Gly Pro Gly Arg Cys Cys Arg Leu 
    610                 615                 620                 


His Thr Val Arg Ala Ser Leu Glu Asp Leu Gly Ala Ala Asp Trp Val 
625                 630                 635                 640 


Leu Ser Pro Arg Glu Val Gln Val Thr Met Cys Ile Gly Ala Cys Pro 
                645                 650                 655     


Ser Gln Phe Arg Ala Ala Asn Met His Ala Gln Ile Lys Thr Ser Leu 
            660                 665                 670         


His Arg Leu Lys Pro Asp Thr Val Pro Ala Pro Cys Cys Val Pro Ala 
        675                 680                 685             


Ser Tyr Asn Pro Met Val Leu Ile Gln Lys Thr Asp Thr Gly Val Ser 
    690                 695                 700                 


Leu Gln Thr Tyr Asp Asp Leu Leu Ala Lys Asp Cys His Cys Ile 
705                 710                 715                 


<210>  73
<211>  719
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fusion protein

<400>  73

Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu 
1               5                   10                  15      


Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln 
            20                  25                  30          


Gln Ser Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr Glu 
        35                  40                  45              


Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys 
    50                  55                  60                  


Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu 
65                  70                  75                  80  


Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro 
                85                  90                  95      


Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu 
            100                 105                 110         


Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe His 
        115                 120                 125             


Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg 
    130                 135                 140                 


Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg 
145                 150                 155                 160 


Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala 
                165                 170                 175     


Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser 
            180                 185                 190         


Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu 
        195                 200                 205             


Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro 
    210                 215                 220                 


Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys 
225                 230                 235                 240 


Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp 
                245                 250                 255     


Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser 
            260                 265                 270         


Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His 
        275                 280                 285             


Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser 
    290                 295                 300                 


Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala 
305                 310                 315                 320 


Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg 
                325                 330                 335     


Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys Thr 
            340                 345                 350         


Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His Glu 
        355                 360                 365             


Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro 
    370                 375                 380                 


Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu 
385                 390                 395                 400 


Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro 
                405                 410                 415     


Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly Lys 
            420                 425                 430         


Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys 
        435                 440                 445             


Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu His 
    450                 455                 460                 


Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser 
465                 470                 475                 480 


Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr 
                485                 490                 495     


Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala Asp 
            500                 505                 510         


Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala 
        515                 520                 525             


Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln Leu 
    530                 535                 540                 


Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys Lys 
545                 550                 555                 560 


Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu Val 
                565                 570                 575     


Ala Ala Ser Gln Ala Ala Leu Gly Leu Gly Ser Gly Gly Gly Gly Ser 
            580                 585                 590         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala 
        595                 600                 605             


Arg Asn Gly Asp His Cys Pro Leu Gly Pro Gly Arg Cys Cys Arg Leu 
    610                 615                 620                 


His Thr Val Arg Ala Ser Leu Glu Asp Leu Gly Trp Ala Asp Trp Val 
625                 630                 635                 640 


Leu Ser Pro Arg Glu Val Gln Val Thr Met Cys Ile Gly Ala Cys Pro 
                645                 650                 655     


Ser Gln Phe Arg Ala Ala Asn Met His Ala Ala Ile Lys Thr Ala Leu 
            660                 665                 670         


His Ala Leu Lys Pro Asp Thr Val Pro Ala Pro Cys Cys Val Pro Ala 
        675                 680                 685             


Ser Tyr Asn Pro Met Val Leu Ile Gln Lys Thr Asp Thr Gly Val Ser 
    690                 695                 700                 


Leu Gln Thr Tyr Asp Asp Leu Leu Ala Lys Asp Cys His Cys Ile 
705                 710                 715                 


<210>  74
<211>  719
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fusion protein

<400>  74

Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu 
1               5                   10                  15      


Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln 
            20                  25                  30          


Gln Ser Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr Glu 
        35                  40                  45              


Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys 
    50                  55                  60                  


Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu 
65                  70                  75                  80  


Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro 
                85                  90                  95      


Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu 
            100                 105                 110         


Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe His 
        115                 120                 125             


Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg 
    130                 135                 140                 


Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg 
145                 150                 155                 160 


Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala 
                165                 170                 175     


Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser 
            180                 185                 190         


Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu 
        195                 200                 205             


Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro 
    210                 215                 220                 


Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys 
225                 230                 235                 240 


Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp 
                245                 250                 255     


Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser 
            260                 265                 270         


Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His 
        275                 280                 285             


Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser 
    290                 295                 300                 


Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala 
305                 310                 315                 320 


Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg 
                325                 330                 335     


Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys Thr 
            340                 345                 350         


Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His Glu 
        355                 360                 365             


Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro 
    370                 375                 380                 


Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu 
385                 390                 395                 400 


Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro 
                405                 410                 415     


Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly Lys 
            420                 425                 430         


Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys 
        435                 440                 445             


Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu His 
    450                 455                 460                 


Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser 
465                 470                 475                 480 


Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr 
                485                 490                 495     


Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala Asp 
            500                 505                 510         


Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala 
        515                 520                 525             


Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln Leu 
    530                 535                 540                 


Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys Lys 
545                 550                 555                 560 


Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu Val 
                565                 570                 575     


Ala Ala Ser Gln Ala Ala Leu Gly Leu Gly Ser Gly Gly Gly Gly Ser 
            580                 585                 590         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala 
        595                 600                 605             


Arg Asn Gly Asp His Cys Pro Leu Gly Pro Gly Arg Cys Cys Arg Leu 
    610                 615                 620                 


His Thr Val Arg Ala Ser Leu Glu Asp Leu Gly Ala Ala Asp Trp Val 
625                 630                 635                 640 


Leu Ser Pro Arg Glu Val Gln Val Thr Met Cys Ile Gly Ala Cys Pro 
                645                 650                 655     


Ser Gln Phe Arg Ala Ala Asn Met His Ala Ala Ala Lys Thr Ser Leu 
            660                 665                 670         


His Arg Leu Lys Pro Asp Thr Val Pro Ala Pro Cys Cys Val Pro Ala 
        675                 680                 685             


Ser Tyr Asn Pro Met Val Leu Ile Gln Lys Thr Asp Thr Gly Val Ser 
    690                 695                 700                 


Leu Gln Thr Tyr Asp Asp Leu Leu Ala Lys Asp Cys His Cys Ile 
705                 710                 715                 


<210>  75
<211>  719
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fusion protein

<400>  75

Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu 
1               5                   10                  15      


Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln 
            20                  25                  30          


Gln Ser Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr Glu 
        35                  40                  45              


Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys 
    50                  55                  60                  


Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu 
65                  70                  75                  80  


Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro 
                85                  90                  95      


Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu 
            100                 105                 110         


Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe His 
        115                 120                 125             


Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg 
    130                 135                 140                 


Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg 
145                 150                 155                 160 


Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala 
                165                 170                 175     


Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser 
            180                 185                 190         


Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu 
        195                 200                 205             


Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro 
    210                 215                 220                 


Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys 
225                 230                 235                 240 


Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp 
                245                 250                 255     


Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser 
            260                 265                 270         


Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His 
        275                 280                 285             


Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser 
    290                 295                 300                 


Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala 
305                 310                 315                 320 


Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg 
                325                 330                 335     


Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys Thr 
            340                 345                 350         


Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His Glu 
        355                 360                 365             


Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro 
    370                 375                 380                 


Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu 
385                 390                 395                 400 


Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro 
                405                 410                 415     


Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly Lys 
            420                 425                 430         


Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys 
        435                 440                 445             


Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu His 
    450                 455                 460                 


Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser 
465                 470                 475                 480 


Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr 
                485                 490                 495     


Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala Asp 
            500                 505                 510         


Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala 
        515                 520                 525             


Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln Leu 
    530                 535                 540                 


Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys Lys 
545                 550                 555                 560 


Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu Val 
                565                 570                 575     


Ala Ala Ser Gln Ala Ala Leu Gly Leu Gly Ser Gly Gly Gly Gly Ser 
            580                 585                 590         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala 
        595                 600                 605             


Arg Asn Gly Asp His Cys Pro Leu Gly Pro Gly Arg Cys Cys Arg Leu 
    610                 615                 620                 


His Thr Val Arg Ala Ser Leu Glu Asp Leu Gly Ala Ala Asp Ala Val 
625                 630                 635                 640 


Leu Ser Pro Arg Glu Val Gln Val Thr Met Cys Ile Gly Ala Cys Pro 
                645                 650                 655     


Ser Gln Phe Arg Ala Ala Asn Met His Ala Gln Ile Lys Thr Ser Leu 
            660                 665                 670         


His Arg Leu Lys Pro Asp Thr Val Pro Ala Pro Cys Cys Val Pro Ala 
        675                 680                 685             


Ser Tyr Asn Pro Met Val Leu Ile Gln Lys Thr Asp Thr Gly Val Ser 
    690                 695                 700                 


Leu Gln Thr Tyr Asp Asp Leu Leu Ala Lys Asp Cys His Cys Ile 
705                 710                 715                 


<210>  76
<211>  2157
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  fusion protein coding sequence

<400>  76
gacgcccaca agagcgaggt ggcccaccgg ttcaaggacc tgggcgagga gaacttcaag       60

gccctggtgc tgatcgcctt cgcccagtac ctgcagcagt cccccttcga ggaccacgtg      120

aagctggtga acgaggtgac cgagttcgcc aagacctgcg tggccgacga gagcgccgag      180

aactgcgaca agagcctgca caccctgttc ggcgacaagc tgtgcaccgt ggccaccctg      240

cgggagacct acggcgagat ggccgactgc tgcgccaagc aggagcccga gcggaacgag      300

tgcttcctgc agcacaagga cgacaacccc aacctgcccc ggctggtgcg gcccgaggtg      360

gacgtgatgt gcaccgcctt ccacgacaac gaggagacct tcctgaagaa gtacctgtac      420

gagatcgccc ggcggcaccc ctacttctac gcccccgagc tgctgttctt cgccaagcgg      480

tacaaggccg ccttcaccga gtgctgccag gccgccgaca aggccgcctg cctgctgccc      540

aagctggacg agctgcggga cgagggcaag gccagcagcg ccaagcagcg gctgaagtgc      600

gccagcctgc agaagttcgg cgagcgggcc ttcaaggcct gggccgtggc ccggctgagc      660

cagcggttcc ccaaggccga gttcgccgag gtgagcaagc tggtgaccga cctgaccaag      720

gtgcacaccg agtgctgcca cggcgacctg ctggagtgcg ccgacgaccg ggccgacctg      780

gccaagtaca tctgcgagaa ccaggacagc atcagcagca agctgaagga gtgctgcgag      840

aagcccctgc tggagaagag ccactgcatc gccgaggtgg agaacgacga gatgcccgcc      900

gacctgccca gcctggccgc cgacttcgtg gagagcaagg acgtgtgcaa gaactacgcc      960

gaggccaagg acgtgttcct gggcatgttc ctgtacgagt acgcccggcg gcaccccgac     1020

tacagcgtgg tgctgctgct gcggctggcc aagacctacg agaccaccct ggagaagtgc     1080

tgcgccgccg ccgaccccca cgagtgctac gccaaggtgt tcgacgagtt caagcccctg     1140

gtggaggagc cccagaacct gatcaagcag aactgcgagc tgttcgagca gctgggcgag     1200

tacaagttcc agaacgccct gctggtgcgg tacaccaaga aggtgcccca ggtgagcacc     1260

cccaccctgg tggaggtgag ccggaacctg ggcaaggtgg gcagcaagtg ctgcaagcac     1320

cccgaggcca agcggatgcc ctgcgccgag gactacctga gcgtggtgct gaaccagctg     1380

tgcgtgctgc acgagaagac ccccgtgagc gaccgggtga ccaagtgctg caccgagagc     1440

ctggtgaacc ggcggccctg cttcagcgcc ctggaggtgg acgagaccta cgtgcccaag     1500

gagttcaacg ccgagacctt caccttccac gccgacatct gcaccctgag cgagaaggag     1560

cggcagatca agaagcagac cgccctggtg gagctggtga agcacaagcc caaggccacc     1620

aaggagcagc tgaaggccgt gatggacgac ttcgccgcct tcgtggagaa gtgctgcaag     1680

gccgacgaca aggagacctg cttcgccgag gagggcaaga agctggtggc cgccagccag     1740

gccgccctgg gcctgggcag cggcggcggc ggcagcggcg gcggcggatc tggtggaggt     1800

ggcagtggag gagggggatc cgctcgcaac ggtgaccact gccctctggg tcctggtcgc     1860

tgctgccgcc tgcacaccgt tcgcgcttct ctggaagacc tgggttgggc tgactgggtt     1920

ctgtctcctc gcgaagttca ggttaccatg tgcatcggtg cttgcccttc tcagttccgc     1980

gctgctaaca tgcacgctca gatcaaaacc tctctgcacc gcctgaaacc tgacaccgtt     2040

cctgctcctt gctgcgttcc tgcttcttac aaccctatgg ttctgatcca gaaaaccgac     2100

accggtgttt ctctgcagac ctacgacgac ctgctggcta aagactgcca ctgcatc        2157


<210>  77
<211>  2133
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  fusion protein coding sequence

<400>  77
gatgctcata agtccgaagt cgcccacaga ttcaaggacc tcggagaaga aaattttaag       60

gccctcgtgc ttatcgcctt cgcccaatac ctccagcagt ccccgttcga ggaccacgtg      120

aagctcgtga acgaagtgac cgagtttgcc aagacttgtg tggcggatga atccgccgag      180

aactgcgaca agagcctcca cacgctgttc ggcgacaagc tgtgcaccgt cgccacgctg      240

agagaaactt acggagagat ggccgactgc tgcgcaaagc aggagccgga acggaacgaa      300

tgcttcctgc aacataagga cgataaccct aacttgcctc gcctggtccg ccctgaggtc      360

gacgtgatgt gcaccgcgtt ccacgacaac gaggaaacct ttcttaagaa gtacctgtac      420

gagattgcgc ggaggcaccc ttatttctac gcccccgaac tgttgttctt cgccaagcgg      480

tacaaggctg cctttaccga atgctgccag gccgccgata aggcggcttg cctgctgccg      540

aagctcgacg agttgcgcga tgaggggaag gcgtcctccg ctaagcagcg gctgaaatgt      600

gcgagcctcc agaagttcgg ggagcgcgcc ttcaaggcct gggccgtggc gcgcctgtct      660

caacggttcc cgaaggccga gttcgccgaa gtgtcgaagc tggtcaccga cctgacgaaa      720

gtgcacaccg aatgttgtca cggcgatctg ctggaatgcg ccgatgacag agccgatttg      780

gccaagtaca tctgcgaaaa ccaggacagc atttcgtcaa agctgaagga atgctgcgaa      840

aagcccttgc tggaaaagtc ccactgcatc gcggaagtgg agaacgacga gatgcccgcc      900

gacctcccgt ccctggccgc cgatttcgtg gagtcgaagg atgtgtgcaa gaactacgca      960

gaagccaagg acgtgttcct gggaatgttt ctgtatgagt acgcccgccg ccacccggac     1020

tactcggtcg tgctcctgct gcgactggca aagacctacg aaaccactct ggagaagtgc     1080

tgcgccgccg cggacccgca cgagtgctac gcaaaggtgt tcgacgagtt caagccactt     1140

gtcgaggagc ctcagaacct gatcaagcag aactgcgaac tgttcgagca gctgggagag     1200

tacaaattcc agaacgcgct tctcgtgcgc tacaccaaga aggtccccca ggtgtccact     1260

ccgaccctgg tggaagtgtc caggaacctg ggaaaggtcg gctccaagtg ttgcaagcat     1320

cccgaggcta agcgcatgcc ctgcgccgag gactacttgt ccgtggtgct gaatcagctg     1380

tgcgtgctcc atgaaaagac cccagtgtcc gacagagtga ccaagtgctg taccgaatcg     1440

ctcgtgaacc ggcggccgtg cttttccgca ctggaggtgg acgaaaccta cgtgccgaag     1500

gagttcaacg cagaaacctt cactttccac gccgacatct gcactctgtc cgagaaggag     1560

cggcagatta agaagcagac tgccctggtg gagcttgtga aacacaagcc taaggccacc     1620

aaagagcagc tgaaggccgt catggatgat ttcgcggcct tcgtggaaaa gtgttgtaaa     1680

gcggacgaca aggagacttg cttcgccgaa gaaggaaaga agctcgtggc agcgtcacag     1740

gccgctctgg gcctcgctag cggtggaggg ggcagcggtg gtggaggatc cggtaccgcg     1800

cgcaacgggg accactgtcc gctcgggccc gggcgttgct gccgtctgca cacggtccgc     1860

gcgtcgctgg aagacctggg ctgggccgat tgggtgctgt cgccacggga ggtgcaagtg     1920

accatgtgca tcggcgcgtg cccgagccag ttccgggcgg caaacatgca cgcgcagatc     1980

aagacgagcc tgcaccgcct gaagcccgac acggtgccag cgccctgctg cgtgcccgcc     2040

agctacaatc ccatggtgct cattcaaaag accgacaccg gggtgtcgct ccagacctat     2100

gatgacttgt tagccaaaga ctgccactgc ata                                  2133


<210>  78
<211>  2223
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  fusion protein coding sequence

<400>  78
gatgctcata agtccgaagt cgcccacaga ttcaaggacc tcggagaaga aaattttaag       60

gccctcgtgc ttatcgcctt cgcccaatac ctccagcagt ccccgttcga ggaccacgtg      120

aagctcgtga acgaagtgac cgagtttgcc aagacttgtg tggcggatga atccgccgag      180

aactgcgaca agagcctcca cacgctgttc ggcgacaagc tgtgcaccgt cgccacgctg      240

agagaaactt acggagagat ggccgactgc tgcgcaaagc aggagccgga acggaacgaa      300

tgcttcctgc aacataagga cgataaccct aacttgcctc gcctggtccg ccctgaggtc      360

gacgtgatgt gcaccgcgtt ccacgacaac gaggaaacct ttcttaagaa gtacctgtac      420

gagattgcgc ggaggcaccc ttatttctac gcccccgaac tgttgttctt cgccaagcgg      480

tacaaggctg cctttaccga atgctgccag gccgccgata aggcggcttg cctgctgccg      540

aagctcgacg agttgcgcga tgaggggaag gcgtcctccg ctaagcagcg gctgaaatgt      600

gcgagcctcc agaagttcgg ggagcgcgcc ttcaaggcct gggccgtggc gcgcctgtct      660

caacggttcc cgaaggccga gttcgccgaa gtgtcgaagc tggtcaccga cctgacgaaa      720

gtgcacaccg aatgttgtca cggcgatctg ctggaatgcg ccgatgacag agccgatttg      780

gccaagtaca tctgcgaaaa ccaggacagc atttcgtcaa agctgaagga atgctgcgaa      840

aagcccttgc tggaaaagtc ccactgcatc gcggaagtgg agaacgacga gatgcccgcc      900

gacctcccgt ccctggccgc cgatttcgtg gagtcgaagg atgtgtgcaa gaactacgca      960

gaagccaagg acgtgttcct gggaatgttt ctgtatgagt acgcccgccg ccacccggac     1020

tactcggtcg tgctcctgct gcgactggca aagacctacg aaaccactct ggagaagtgc     1080

tgcgccgccg cggacccgca cgagtgctac gcaaaggtgt tcgacgagtt caagccactt     1140

gtcgaggagc ctcagaacct gatcaagcag aactgcgaac tgttcgagca gctgggagag     1200

tacaaattcc agaacgcgct tctcgtgcgc tacaccaaga aggtccccca ggtgtccact     1260

ccgaccctgg tggaagtgtc caggaacctg ggaaaggtcg gctccaagtg ttgcaagcat     1320

cccgaggcta agcgcatgcc ctgcgccgag gactacttgt ccgtggtgct gaatcagctg     1380

tgcgtgctcc atgaaaagac cccagtgtcc gacagagtga ccaagtgctg taccgaatcg     1440

ctcgtgaacc ggcggccgtg cttttccgca ctggaggtgg acgaaaccta cgtgccgaag     1500

gagttcaacg cagaaacctt cactttccac gccgacatct gcactctgtc cgagaaggag     1560

cggcagatta agaagcagac tgccctggtg gagcttgtga aacacaagcc taaggccacc     1620

aaagagcagc tgaaggccgt catggatgat ttcgcggcct tcgtggaaaa gtgttgtaaa     1680

gcggacgaca aggagacttg cttcgccgaa gaaggaaaga agctcgtggc agcgtcacag     1740

gccgctctgg gcctcgctag cggaggtggc ggatcaggtg gcggaggtag cggtggaggc     1800

ggctctggcg gaggtggatc aggcggagga ggttccggtg gaggaggctc aggaggagga     1860

ggaagtggag gagggggatc cggtaccgcg cgcaacgggg accactgtcc gctcgggccc     1920

gggcgttgct gccgtctgca cacggtccgc gcgtcgctgg aagacctggg ctgggccgat     1980

tgggtgctgt cgccacggga ggtgcaagtg accatgtgca tcggcgcgtg cccgagccag     2040

ttccgggcgg caaacatgca cgcgcagatc aagacgagcc tgcaccgcct gaagcccgac     2100

acggtgccag cgccctgctg cgtgcccgcc agctacaatc ccatggtgct cattcaaaag     2160

accgacaccg gggtgtcgct ccagacctat gatgacttgt tagccaaaga ctgccactgc     2220

ata                                                                   2223


<210>  79
<211>  2133
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  fusion protein coding sequence

<400>  79
gatgctcata agtccgaagt cgcccacaga ttcaaggacc tcggagaaga aaattttaag       60

gccctcgtgc ttatcgcctt cgcccaatac ctccagcagt ccccgttcga ggaccacgtg      120

aagctcgtga acgaagtgac cgagtttgcc aagacttgtg tggcggatga atccgccgag      180

aactgcgaca agagcctcca cacgctgttc ggcgacaagc tgtgcaccgt cgccacgctg      240

agagaaactt acggagagat ggccgactgc tgcgcaaagc aggagccgga acggaacgaa      300

tgcttcctgc aacataagga cgataaccct aacttgcctc gcctggtccg ccctgaggtc      360

gacgtgatgt gcaccgcgtt ccacgacaac gaggaaacct ttcttaagaa gtacctgtac      420

gagattgcgc ggaggcaccc ttatttctac gcccccgaac tgttgttctt cgccaagcgg      480

tacaaggctg cctttaccga atgctgccag gccgccgata aggcggcttg cctgctgccg      540

aagctcgacg agttgcgcga tgaggggaag gcgtcctccg ctaagcagcg gctgaaatgt      600

gcgagcctcc agaagttcgg ggagcgcgcc ttcaaggcct gggccgtggc gcgcctgtct      660

caacggttcc cgaaggccga gttcgccgaa gtgtcgaagc tggtcaccga cctgacgaaa      720

gtgcacaccg aatgttgtca cggcgatctg ctggaatgcg ccgatgacag agccgatttg      780

gccaagtaca tctgcgaaaa ccaggacagc atttcgtcaa agctgaagga atgctgcgaa      840

aagcccttgc tggaaaagtc ccactgcatc gcggaagtgg agaacgacga gatgcccgcc      900

gacctcccgt ccctggccgc cgatttcgtg gagtcgaagg atgtgtgcaa gaactacgca      960

gaagccaagg acgtgttcct gggaatgttt ctgtatgagt acgcccgccg ccacccggac     1020

tactcggtcg tgctcctgct gcgactggca aagacctacg aaaccactct ggagaagtgc     1080

tgcgccgccg cggacccgca cgagtgctac gcaaaggtgt tcgacgagtt caagccactt     1140

gtcgaggagc ctcagaacct gatcaagcag aactgcgaac tgttcgagca gctgggagag     1200

tacaaattcc agaacgcgct tctcgtgcgc tacaccaaga aggtccccca ggtgtccact     1260

ccgaccctgg tggaagtgtc caggaacctg ggaaaggtcg gctccaagtg ttgcaagcat     1320

cccgaggcta agcgcatgcc ctgcgccgag gactacttgt ccgtggtgct gaatcagctg     1380

tgcgtgctcc atgaaaagac cccagtgtcc gacagagtga ccaagtgctg taccgaatcg     1440

ctcgtgaacc ggcggccgtg cttttccgca ctggaggtgg acgaaaccta cgtgccgaag     1500

gagttcaacg cagaaacctt cactttccac gccgacatct gcactctgtc cgagaaggag     1560

cggcagatta agaagcagac tgccctggtg gagcttgtga aacacaagcc taaggccacc     1620

aaagagcagc tgaaggccgt catggatgat ttcgcggcct tcgtggaaaa gtgttgtaaa     1680

gcggacgaca aggagacttg cttcgccgaa gaaggaaaga agctcgtggc agcgtcacag     1740

gccgctctgg gcctcgctag cgcacctgcc cccgctccag ctcctgcacc aggtaccgcg     1800

cgcaacgggg accactgtcc gctcgggccc gggcgttgct gccgtctgca cacggtccgc     1860

gcgtcgctgg aagacctggg ctgggccgat tgggtgctgt cgccacggga ggtgcaagtg     1920

accatgtgca tcggcgcgtg cccgagccag ttccgggcgg caaacatgca cgcgcagatc     1980

aagacgagcc tgcaccgcct gaagcccgac acggtgccag cgccctgctg cgtgcccgcc     2040

agctacaatc ccatggtgct cattcaaaag accgacaccg gggtgtcgct ccagacctat     2100

gatgacttgt tagccaaaga ctgccactgc ata                                  2133


<210>  80
<211>  2163
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  fusion protein coding sequence

<400>  80
gatgctcata agtccgaagt cgcccacaga ttcaaggacc tcggagaaga aaattttaag       60

gccctcgtgc ttatcgcctt cgcccaatac ctccagcagt ccccgttcga ggaccacgtg      120

aagctcgtga acgaagtgac cgagtttgcc aagacttgtg tggcggatga atccgccgag      180

aactgcgaca agagcctcca cacgctgttc ggcgacaagc tgtgcaccgt cgccacgctg      240

agagaaactt acggagagat ggccgactgc tgcgcaaagc aggagccgga acggaacgaa      300

tgcttcctgc aacataagga cgataaccct aacttgcctc gcctggtccg ccctgaggtc      360

gacgtgatgt gcaccgcgtt ccacgacaac gaggaaacct ttcttaagaa gtacctgtac      420

gagattgcgc ggaggcaccc ttatttctac gcccccgaac tgttgttctt cgccaagcgg      480

tacaaggctg cctttaccga atgctgccag gccgccgata aggcggcttg cctgctgccg      540

aagctcgacg agttgcgcga tgaggggaag gcgtcctccg ctaagcagcg gctgaaatgt      600

gcgagcctcc agaagttcgg ggagcgcgcc ttcaaggcct gggccgtggc gcgcctgtct      660

caacggttcc cgaaggccga gttcgccgaa gtgtcgaagc tggtcaccga cctgacgaaa      720

gtgcacaccg aatgttgtca cggcgatctg ctggaatgcg ccgatgacag agccgatttg      780

gccaagtaca tctgcgaaaa ccaggacagc atttcgtcaa agctgaagga atgctgcgaa      840

aagcccttgc tggaaaagtc ccactgcatc gcggaagtgg agaacgacga gatgcccgcc      900

gacctcccgt ccctggccgc cgatttcgtg gagtcgaagg atgtgtgcaa gaactacgca      960

gaagccaagg acgtgttcct gggaatgttt ctgtatgagt acgcccgccg ccacccggac     1020

tactcggtcg tgctcctgct gcgactggca aagacctacg aaaccactct ggagaagtgc     1080

tgcgccgccg cggacccgca cgagtgctac gcaaaggtgt tcgacgagtt caagccactt     1140

gtcgaggagc ctcagaacct gatcaagcag aactgcgaac tgttcgagca gctgggagag     1200

tacaaattcc agaacgcgct tctcgtgcgc tacaccaaga aggtccccca ggtgtccact     1260

ccgaccctgg tggaagtgtc caggaacctg ggaaaggtcg gctccaagtg ttgcaagcat     1320

cccgaggcta agcgcatgcc ctgcgccgag gactacttgt ccgtggtgct gaatcagctg     1380

tgcgtgctcc atgaaaagac cccagtgtcc gacagagtga ccaagtgctg taccgaatcg     1440

ctcgtgaacc ggcggccgtg cttttccgca ctggaggtgg acgaaaccta cgtgccgaag     1500

gagttcaacg cagaaacctt cactttccac gccgacatct gcactctgtc cgagaaggag     1560

cggcagatta agaagcagac tgccctggtg gagcttgtga aacacaagcc taaggccacc     1620

aaagagcagc tgaaggccgt catggatgat ttcgcggcct tcgtggaaaa gtgttgtaaa     1680

gcggacgaca aggagacttg cttcgccgaa gaaggaaaga agctcgtggc agcgtcacag     1740

gccgctctgg gcctcgctag cgcacctgcc cccgctccag cacccgcccc agcccctgct     1800

cccgcaccag ctcctgcacc aggtaccgct cgcaacggtg accactgccc tctgggtcct     1860

ggtcgctgct gccgcctgca caccgttcgc gcttctctgg aagacctggg ttgggctgac     1920

tgggttctgt ctcctcgcga agttcaggtt accatgtgca tcggtgcttg cccttctcag     1980

ttccgcgctg ctaacatgca cgctcagatc aaaacctctc tgcaccgcct gaaacctgac     2040

accgttcctg ctccttgctg cgttcctgct tcttacaacc ctatggttct gatccagaaa     2100

accgacaccg gtgtttctct gcagacctac gacgacctgc tggctaaaga ctgccactgc     2160

atc                                                                   2163


<210>  81
<211>  2223
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  fusion protein coding sequence

<400>  81
gatgctcata agtccgaagt cgcccacaga ttcaaggacc tcggagaaga aaattttaag       60

gccctcgtgc ttatcgcctt cgcccaatac ctccagcagt ccccgttcga ggaccacgtg      120

aagctcgtga acgaagtgac cgagtttgcc aagacttgtg tggcggatga atccgccgag      180

aactgcgaca agagcctcca cacgctgttc ggcgacaagc tgtgcaccgt cgccacgctg      240

agagaaactt acggagagat ggccgactgc tgcgcaaagc aggagccgga acggaacgaa      300

tgcttcctgc aacataagga cgataaccct aacttgcctc gcctggtccg ccctgaggtc      360

gacgtgatgt gcaccgcgtt ccacgacaac gaggaaacct ttcttaagaa gtacctgtac      420

gagattgcgc ggaggcaccc ttatttctac gcccccgaac tgttgttctt cgccaagcgg      480

tacaaggctg cctttaccga atgctgccag gccgccgata aggcggcttg cctgctgccg      540

aagctcgacg agttgcgcga tgaggggaag gcgtcctccg ctaagcagcg gctgaaatgt      600

gcgagcctcc agaagttcgg ggagcgcgcc ttcaaggcct gggccgtggc gcgcctgtct      660

caacggttcc cgaaggccga gttcgccgaa gtgtcgaagc tggtcaccga cctgacgaaa      720

gtgcacaccg aatgttgtca cggcgatctg ctggaatgcg ccgatgacag agccgatttg      780

gccaagtaca tctgcgaaaa ccaggacagc atttcgtcaa agctgaagga atgctgcgaa      840

aagcccttgc tggaaaagtc ccactgcatc gcggaagtgg agaacgacga gatgcccgcc      900

gacctcccgt ccctggccgc cgatttcgtg gagtcgaagg atgtgtgcaa gaactacgca      960

gaagccaagg acgtgttcct gggaatgttt ctgtatgagt acgcccgccg ccacccggac     1020

tactcggtcg tgctcctgct gcgactggca aagacctacg aaaccactct ggagaagtgc     1080

tgcgccgccg cggacccgca cgagtgctac gcaaaggtgt tcgacgagtt caagccactt     1140

gtcgaggagc ctcagaacct gatcaagcag aactgcgaac tgttcgagca gctgggagag     1200

tacaaattcc agaacgcgct tctcgtgcgc tacaccaaga aggtccccca ggtgtccact     1260

ccgaccctgg tggaagtgtc caggaacctg ggaaaggtcg gctccaagtg ttgcaagcat     1320

cccgaggcta agcgcatgcc ctgcgccgag gactacttgt ccgtggtgct gaatcagctg     1380

tgcgtgctcc atgaaaagac cccagtgtcc gacagagtga ccaagtgctg taccgaatcg     1440

ctcgtgaacc ggcggccgtg cttttccgca ctggaggtgg acgaaaccta cgtgccgaag     1500

gagttcaacg cagaaacctt cactttccac gccgacatct gcactctgtc cgagaaggag     1560

cggcagatta agaagcagac tgccctggtg gagcttgtga aacacaagcc taaggccacc     1620

aaagagcagc tgaaggccgt catggatgat ttcgcggcct tcgtggaaaa gtgttgtaaa     1680

gcggacgaca aggagacttg cttcgccgaa gaaggaaaga agctcgtggc agcgtcacag     1740

gccgctctgg gcctcgctag cgcacctgcc cccgctccag ccccagctcc tgcacctgct     1800

ccagcaccag ctcctgcacc agctccagcc cctgcacctg cacccgctcc agccccagct     1860

cctgcacctg ctccagcacc aggtaccgcg cgcaacgggg accactgtcc gctcgggccc     1920

gggcgttgct gccgtctgca cacggtccgc gcgtcgctgg aagacctggg ctgggccgat     1980

tgggtgctgt cgccacggga ggtgcaagtg accatgtgca tcggcgcgtg cccgagccag     2040

ttccgggcgg caaacatgca cgcgcagatc aagacgagcc tgcaccgcct gaagcccgac     2100

acggtgccag cgccctgctg cgtgcccgcc agctacaatc ccatggtgct cattcaaaag     2160

accgacaccg gggtgtcgct ccagacctat gatgacttgt tagccaaaga ctgccactgc     2220

ata                                                                   2223


<210>  82
<211>  2163
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  fusion protein coding sequence

<400>  82
gatgctcata agtccgaagt cgcccacaga ttcaaggacc tcggagaaga aaattttaag       60

gccctcgtgc ttatcgcctt cgcccaatac ctccagcagt ccccgttcga ggaccacgtg      120

aagctcgtga acgaagtgac cgagtttgcc aagacttgtg tggcggatga atccgccgag      180

aactgcgaca agagcctcca cacgctgttc ggcgacaagc tgtgcaccgt cgccacgctg      240

agagaaactt acggagagat ggccgactgc tgcgcaaagc aggagccgga acggaacgaa      300

tgcttcctgc aacataagga cgataaccct aacttgcctc gcctggtccg ccctgaggtc      360

gacgtgatgt gcaccgcgtt ccacgacaac gaggaaacct ttcttaagaa gtacctgtac      420

gagattgcgc ggaggcaccc ttatttctac gcccccgaac tgttgttctt cgccaagcgg      480

tacaaggctg cctttaccga atgctgccag gccgccgata aggcggcttg cctgctgccg      540

aagctcgacg agttgcgcga tgaggggaag gcgtcctccg ctaagcagcg gctgaaatgt      600

gcgagcctcc agaagttcgg ggagcgcgcc ttcaaggcct gggccgtggc gcgcctgtct      660

caacggttcc cgaaggccga gttcgccgaa gtgtcgaagc tggtcaccga cctgacgaaa      720

gtgcacaccg aatgttgtca cggcgatctg ctggaatgcg ccgatgacag agccgatttg      780

gccaagtaca tctgcgaaaa ccaggacagc atttcgtcaa agctgaagga atgctgcgaa      840

aagcccttgc tggaaaagtc ccactgcatc gcggaagtgg agaacgacga gatgcccgcc      900

gacctcccgt ccctggccgc cgatttcgtg gagtcgaagg atgtgtgcaa gaactacgca      960

gaagccaagg acgtgttcct gggaatgttt ctgtatgagt acgcccgccg ccacccggac     1020

tactcggtcg tgctcctgct gcgactggca aagacctacg aaaccactct ggagaagtgc     1080

tgcgccgccg cggacccgca cgagtgctac gcaaaggtgt tcgacgagtt caagccactt     1140

gtcgaggagc ctcagaacct gatcaagcag aactgcgaac tgttcgagca gctgggagag     1200

tacaaattcc agaacgcgct tctcgtgcgc tacaccaaga aggtccccca ggtgtccact     1260

ccgaccctgg tggaagtgtc caggaacctg ggaaaggtcg gctccaagtg ttgcaagcat     1320

cccgaggcta agcgcatgcc ctgcgccgag gactacttgt ccgtggtgct gaatcagctg     1380

tgcgtgctcc atgaaaagac cccagtgtcc gacagagtga ccaagtgctg taccgaatcg     1440

ctcgtgaacc ggcggccgtg cttttccgca ctggaggtgg acgaaaccta cgtgccgaag     1500

gagttcaacg cagaaacctt cactttccac gccgacatct gcactctgtc cgagaaggag     1560

cggcagatta agaagcagac tgccctggtg gagcttgtga aacacaagcc taaggccacc     1620

aaagagcagc tgaaggccgt catggatgat ttcgcggcct tcgtggaaaa gtgttgtaaa     1680

gcggacgaca aggagacttg cttcgccgaa gaaggaaaga agctcgtggc agcgtcacag     1740

gccgctctgg gcctcgctag cgaagcagca gccaaagaag cagccgcaaa agaagcagcc     1800

gctaaggagg ccgcagcaaa gggtaccgcg cgcaacgggg accactgtcc gctcgggccc     1860

gggcgttgct gccgtctgca cacggtccgc gcgtcgctgg aagacctggg ctgggccgat     1920

tgggtgctgt cgccacggga ggtgcaagtg accatgtgca tcggcgcgtg cccgagccag     1980

ttccgggcgg caaacatgca cgcgcagatc aagacgagcc tgcaccgcct gaagcccgac     2040

acggtgccag cgccctgctg cgtgcccgcc agctacaatc ccatggtgct cattcaaaag     2100

accgacaccg gggtgtcgct ccagacctat gatgacttgt tagccaaaga ctgccactgc     2160

ata                                                                   2163


<210>  83
<211>  2157
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  fusion protein coding sequence

<400>  83
gacgcccaca agagcgaggt ggcccaccgg ttcaaggacc tgggcgagga gaacttcaag       60

gccctggtgc tgatcgcctt cgcccagtac ctgcagcagt cccccttcga ggaccacgtg      120

aagctggtga acgaggtgac cgagttcgcc aagacctgcg tggccgacga gagcgccgag      180

aactgcgaca agagcctgca caccctgttc ggcgacaagc tgtgcaccgt ggccaccctg      240

cgggagacct acggcgagat ggccgactgc tgcgccaagc aggagcccga gcggaacgag      300

tgcttcctgc agcacaagga cgacaacccc aacctgcccc ggctggtgcg gcccgaggtg      360

gacgtgatgt gcaccgcctt ccacgacaac gaggagacct tcctgaagaa gtacctgtac      420

gagatcgccc ggcggcaccc ctacttctac gcccccgagc tgctgttctt cgccaagcgg      480

tacaaggccg ccttcaccga gtgctgccag gccgccgaca aggccgcctg cctgctgccc      540

aagctggacg agctgcggga cgagggcaag gccagcagcg ccaagcagcg gctgaagtgc      600

gccagcctgc agaagttcgg cgagcgggcc ttcaaggcct gggccgtggc ccggctgagc      660

cagcggttcc ccaaggccga gttcgccgag gtgagcaagc tggtgaccga cctgaccaag      720

gtgcacaccg agtgctgcca cggcgacctg ctggagtgcg ccgacgaccg ggccgacctg      780

gccaagtaca tctgcgagaa ccaggacagc atcagcagca agctgaagga gtgctgcgag      840

aagcccctgc tggagaagag ccactgcatc gccgaggtgg agaacgacga gatgcccgcc      900

gacctgccca gcctggccgc cgacttcgtg gagagcaagg acgtgtgcaa gaactacgcc      960

gaggccaagg acgtgttcct gggcatgttc ctgtacgagt acgcccggcg gcaccccgac     1020

tacagcgtgg tgctgctgct gcggctggcc aagacctacg agaccaccct ggagaagtgc     1080

tgcgccgccg ccgaccccca cgagtgctac gccaaggtgt tcgacgagtt caagcccctg     1140

gtggaggagc cccagaacct gatcaagcag aactgcgagc tgttcgagca gctgggcgag     1200

tacaagttcc agaacgccct gctggtgcgg tacaccaaga aggtgcccca ggtgagcacc     1260

cccaccctgg tggaggtgag ccggaacctg ggcaaggtgg gcagcaagtg ctgcaagcac     1320

cccgaggcca agcggatgcc ctgcgccgag gactacctga gcgtggtgct gaaccagctg     1380

tgcgtgctgc acgagaagac ccccgtgagc gaccgggtga ccaagtgctg caccgagagc     1440

ctggtgaacc ggcggccctg cttcagcgcc ctggaggtgg acgagaccta cgtgcccaag     1500

gagttcaacg ccgagacctt caccttccac gccgacatct gcaccctgag cgagaaggag     1560

cggcagatca agaagcagac cgccctggtg gagctggtga agcacaagcc caaggccacc     1620

aaggagcagc tgaaggccgt gatggacgac ttcgccgcct tcgtggagaa gtgctgcaag     1680

gccgacgaca aggagacctg cttcgccgag gagggcaaga agctggtggc cgccagccag     1740

gccgccctgg gcctgggcag cggcggcggc ggcagcggcg gcggcggatc tggtggaggt     1800

ggcagtggag gagggggatc cgcgcgcaac ggggaccact gtccgctcgg gcccgggcgt     1860

tgctgccgtc tgcacacggt ccgcgcgtcg ctggaagacc tgggctgggc cgattgggtg     1920

ctgtcgccac gggaggtgca agtgaccatg tgcatcggcg cgtgcccgag ccagttccgg     1980

gcggcaaaca tgcacgcgca gatcaagacg agcctgcacc gcctgaagcc cgacacggtg     2040

ccagcgccct gctgcgtgcc cgccagctac aatcccatgg tgctcattca aaagaccgac     2100

accggggtgt cgctccagac ctatgatgac ttgttagcca aagactgcca ctgcata        2157


<210>  84
<211>  2217
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  fusion protein coding sequence

<400>  84
gatgcacaca agagtgaggt tgctcatcgg tttaaagatt tgggagaaga aaatttcaaa       60

gccttggtgt tgattgcctt tgctcagtat cttcagcagg ccccatttga agatcatgta      120

aaattagtga atgaagtaac tgaatttgca aaaacatgtg ttgctgatga gtcagctgaa      180

aattgtgaca aatcacttca tacccttttt ggagacaaat tatgcacagt tgcaactctt      240

cgtgaaacct atggtgaaat ggctgactgc tgtgcaaaac aagaacctga gagaaatgaa      300

tgcttcttgc aacacaaaga tgacaaccca aacctccccc gattggtgag accagaggtt      360

gatgtgatgt gcactgcttt tcatgacaat gaagagacat ttttgaaaaa atacttatat      420

gaaattgcca gaagacatcc ttacttttat gccccggaac tccttttctt tgctaaaagg      480

tataaagctg cttttacaga atgttgccaa gctgctgata aagctgcctg cctgttgcca      540

aagctcgatg aacttcggga tgaagggaag gcttcgtctg ccaaacagag actcaagtgt      600

gccagtctcc aaaaatttgg agaaagagct ttcaaagcat gggcagtagc tcgcctgagc      660

cagagatttc ccaaagctga gtttgcagaa gtttccaagt tagtgacaga tcttaccaaa      720

gtccacacgg aatgctgcca tggagatctg cttgaatgtg ctgatgacag ggcggacctt      780

gccaagtata tctgtgaaaa tcaagattcg atctccagta aactgaagga atgctgtgaa      840

aaacctctgt tggaaaaatc ccactgcatt gccgaagtgg aaaatgatga gatgcctgct      900

gacttgcctt cattagctgc tgattttgtt gaaagtaagg atgtttgcaa aaactatgct      960

gaggcaaagg atgtcttcct gggcatgttt ttgtatgaat atgcaagaag gcatcctgat     1020

tactctgtcg tgctgctgct gagacttgcc aagacatatg aaaccactct agagaagtgc     1080

tgtgccgctg cagatcctca tgaatgctat gccaaagtgt tcgatgaatt taaacctctt     1140

gtggaagagc ctcagaattt aatcaaacaa aattgtgagc tttttgagca gcttggagag     1200

tacaaattcc agaatgcgct attagttcgt tacaccaaga aagtacccca agtgtcaact     1260

ccaactcttg tagaggtctc aagaaaccta ggaaaagtgg gcagcaaatg ttgtaaacat     1320

cctgaagcaa aaagaatgcc ctgtgcagaa gactatctat ccgtggtcct gaaccagtta     1380

tgtgtgttgc atgagaaaac gccagtaagt gacagagtca ccaaatgctg cacagaatcc     1440

ttggtgaaca ggcgaccatg cttttcagct ctggaagtcg atgaaacata cgttcccaaa     1500

gagtttaatg ctgaaacatt caccttccat gcagatatat gcacactttc tgagaaggag     1560

agacaaatca agaaacaaac tgcacttgtt gagctcgtga aacacaagcc caaggcaaca     1620

aaagagcaac tgaaagctgt tatggatgat ttcgcagctt ttgtagagaa gtgctgcaag     1680

gctgacgata aggagacctg ctttgccgag gagggtaaaa aacttgttgc tgcaagtcaa     1740

gctgccttag gcttaggcag cggcggcggc ggcagcggcg gcggcggatc tggtggaggt     1800

ggcagtggag gagggggatc cggcggcggc ggcagcggcg gcggcggatc tggtggaggt     1860

ggcagtggag gagggggatc cgcgcgcaac ggggaccact gtccgctcgg gcccgggcgt     1920

tgctgccgtc tgcacacggt ccgcgcgtcg ctggaagacc tgggctgggc cgattgggtg     1980

ctgtcgccac gggaggtgca agtgaccatg tgcatcggcg cgtgcccgag ccagttccgg     2040

gcggcaaaca tgcacgcgca gatcaagacg agcctgcacc gcctgaagcc cgacacggtg     2100

ccagcgccct gctgcgtgcc cgccagctac aatcccatgg tgctcattca aaagaccgac     2160

accggggtgt cgctccagac ctatgatgac ttgttagcca aagactgcca ctgcata        2217


<210>  85
<211>  2151
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  fusion protein coding sequence

<400>  85
gatgcacaca agagtgaggt tgctcatcgg tttaaagatt tgggagaaga aaatttcaaa       60

gccttggtgt tgattgcctt tgctcagtat cttcagcagg ccccatttga agatcatgta      120

aaattagtga atgaagtaac tgaatttgca aaaacatgtg ttgctgatga gtcagctgaa      180

aattgtgaca aatcacttca tacccttttt ggagacaaat tatgcacagt tgcaactctt      240

cgtgaaacct atggtgaaat ggctgactgc tgtgcaaaac aagaacctga gagaaatgaa      300

tgcttcttgc aacacaaaga tgacaaccca aacctccccc gattggtgag accagaggtt      360

gatgtgatgt gcactgcttt tcatgacaat gaagagacat ttttgaaaaa atacttatat      420

gaaattgcca gaagacatcc ttacttttat gccccggaac tccttttctt tgctaaaagg      480

tataaagctg cttttacaga atgttgccaa gctgctgata aagctgcctg cctgttgcca      540

aagctcgatg aacttcggga tgaagggaag gcttcgtctg ccaaacagag actcaagtgt      600

gccagtctcc aaaaatttgg agaaagagct ttcaaagcat gggcagtagc tcgcctgagc      660

cagagatttc ccaaagctga gtttgcagaa gtttccaagt tagtgacaga tcttaccaaa      720

gtccacacgg aatgctgcca tggagatctg cttgaatgtg ctgatgacag ggcggacctt      780

gccaagtata tctgtgaaaa tcaagattcg atctccagta aactgaagga atgctgtgaa      840

aaacctctgt tggaaaaatc ccactgcatt gccgaagtgg aaaatgatga gatgcctgct      900

gacttgcctt cattagctgc tgattttgtt gaaagtaagg atgtttgcaa aaactatgct      960

gaggcaaagg atgtcttcct gggcatgttt ttgtatgaat atgcaagaag gcatcctgat     1020

tactctgtcg tgctgctgct gagacttgcc aagacatatg aaaccactct agagaagtgc     1080

tgtgccgctg cagatcctca tgaatgctat gccaaagtgt tcgatgaatt taaacctctt     1140

gtggaagagc ctcagaattt aatcaaacaa aattgtgagc tttttgagca gcttggagag     1200

tacaaattcc agaatgcgct attagttcgt tacaccaaga aagtacccca agtgtcaact     1260

ccaactcttg tagaggtctc aagaaaccta ggaaaagtgg gcagcaaatg ttgtaaacat     1320

cctgaagcaa aaagaatgcc ctgtgcagaa gactatctat ccgtggtcct gaaccagtta     1380

tgtgtgttgc atgagaaaac gccagtaagt gacagagtca ccaaatgctg cacagaatcc     1440

ttggtgaaca ggcgaccatg cttttcagct ctggaagtcg atgaaacata cgttcccaaa     1500

gagtttaatg ctgaaacatt caccttccat gcagatatat gcacactttc tgagaaggag     1560

agacaaatca agaaacaaac tgcacttgtt gagctcgtga aacacaagcc caaggcaaca     1620

aaagagcaac tgaaagctgt tatggatgat ttcgcagctt ttgtagagaa gtgctgcaag     1680

gctgacgata aggagacctg ctttgccgag gagggtaaaa aacttgttgc tgcaagtcaa     1740

gctgccttag gcttagcacc tgcccccgct ccagcacccg ccccagcccc tgctcccgca     1800

ccagctcctg caccagcgcg caacggggac cactgtccgc tcgggcccgg gcgttgctgc     1860

cgtctgcaca cggtccgcgc gtcgctggaa gacctgggct gggccgattg ggtgctgtcg     1920

ccacgggagg tgcaagtgac catgtgcatc ggcgcgtgcc cgagccagtt ccgggcggca     1980

aacatgcacg cgcagatcaa gacgagcctg caccgcctga agcccgacac ggtgccagcg     2040

ccctgctgcg tgcccgccag ctacaatccc atggtgctca ttcaaaagac cgacaccggg     2100

gtgtcgctcc agacctatga tgacttgtta gccaaagact gccactgcat a              2151


<210>  86
<211>  2157
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  fusion protein coding sequence

<400>  86
gatgcacaca agagtgaggt tgctcatcgg tttaaagatt tgggagaaga aaatttcaaa       60

gccttggtgt tgattgcctt tgctcagtat cttcagcagt ccccatttga agatcatgta      120

aaattagtga atgaagtaac tgaatttgca aaaacatgtg ttgctgatga gtcagctgaa      180

aattgtgaca aatcacttca tacccttttt ggagacaaat tatgcacagt tgcaactctt      240

cgtgaaacct atggtgaaat ggctgactgc tgtgcaaaac aagaacctga gagaaatgaa      300

tgcttcttgc aacacaaaga tgacaaccca aacctccccc gattggtgag accagaggtt      360

gatgtgatgt gcactgcttt tcatgacaat gaagagacat ttttgaaaaa atacttatat      420

gaaattgcca gaagacatcc ttacttttat gccccggaac tccttttctt tgctaaaagg      480

tataaagctg cttttacaga atgttgccaa gctgctgata aagctgcctg cctgttgcca      540

aagctcgatg aacttcggga tgaagggaag gcttcgtctg ccaaacagag actcaagtgt      600

gccagtctcc aaaaatttgg agaaagagct ttcaaagcat gggcagtagc tcgcctgagc      660

cagagatttc ccaaagctga gtttgcagaa gtttccaagt tagtgacaga tcttaccaaa      720

gtccacacgg aatgctgcca tggagatctg cttgaatgtg ctgatgacag ggcggacctt      780

gccaagtata tctgtgaaaa tcaagattcg atctccagta aactgaagga atgctgtgaa      840

aaacctctgt tggaaaaatc ccactgcatt gccgaagtgg aaaatgatga gatgcctgct      900

gacttgcctt cattagctgc tgattttgtt gaaagtaagg atgtttgcaa aaactatgct      960

gaggcaaagg atgtcttcct gggcatgttt ttgtatgaat atgcaagaag gcatcctgat     1020

tactctgtcg tgctgctgct gagacttgcc aagacatatg aaaccactct agagaagtgc     1080

tgtgccgctg cagatcctca tgaatgctat gccaaagtgt tcgatgaatt taaacctctt     1140

gtggaagagc ctcagaattt aatcaaacaa aattgtgagc tttttgagca gcttggagag     1200

tacaaattcc agaatgcgct attagttcgt tacaccaaga aagtacccca agtgtcaact     1260

ccaactcttg tagaggtctc aagaaaccta ggaaaagtgg gcagcaaatg ttgtaaacat     1320

cctgaagcaa aaagaatgcc ctgtgcagaa gactatctat ccgtggtcct gaaccagtta     1380

tgtgtgttgc atgagaaaac gccagtaagt gacagagtca ccaaatgctg cacagaatcc     1440

ttggtgaaca ggcgaccatg cttttcagct ctggaagtcg atgaaacata cgttcccaaa     1500

gagtttaatg ctgaaacatt caccttccat gcagatatat gcacactttc tgagaaggag     1560

agacaaatca agaaacaaac tgcacttgtt gagctcgtga aacacaagcc caaggcaaca     1620

aaagagcaac tgaaagctgt tatggatgat ttcgcagctt ttgtagagaa gtgctgcaag     1680

gctgacgata aggagacctg ctttgccgag gagggtaaaa aacttgttgc tgcaagtcaa     1740

gctgccttag gcttaggcag cggcggcggc ggcagcggcg gcggcggatc tggtggaggt     1800

ggcagtggag gagggggatc cgcgcgcaac ggggaccact gtccgctcgg gcccgggcgt     1860

tgctgccgtc tgcacacggt ccgcgcgtcg ctggaagacc tgggctgggc cgattgggtg     1920

ctgtcgccac gggaggtgca agtgaccatg tgcatcggcg cgtgcccgag ccagttccgg     1980

gcggcaaaca tgcacgcgca gatcaagacg agcctgcacc gcctgaagcc cgacacggtg     2040

ccagcgccct gctgcgtgcc cgccagctac aatcccatgg tgctcattca aaagaccgac     2100

accggggtgt cgctccagac ctatgatgac ttgttagcca aagactgcca ctgcata        2157


<210>  87
<211>  2157
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  fusion protein coding sequence

<400>  87
gacgcccaca agagcgaggt ggcccacaga ttcaaggacc tgggcgagga aaacttcaag       60

gccctggtgc tgatcgcctt cgcccagtac ctgcagcaga gccccttcga ggaccacgtg      120

aagctggtca acgaagtgac cgagttcgcc aagacctgcg tggccgacga gagcgccgag      180

aactgcgaca agagcctgca caccctgttc ggcgacaagc tgtgcaccgt ggccaccctg      240

cgggaaacct acggcgagat ggccgactgc tgcgccaagc aggaacccga gcggaacgag      300

tgcttcctgc agcacaagga cgacaacccc aacctgccca gactcgtgcg gcccgaggtg      360

gacgtgatgt gcaccgcctt ccacgacaac gaggaaacct tcctgaagaa gtacctgtac      420

gagatcgcca gacggcaccc ctacttctac gcccccgagc tgctgttctt cgccaagcgg      480

tacaaggccg ccttcaccga gtgctgccag gccgccgata aggccgcctg cctgctgccc      540

aagctggacg agctgagaga tgagggcaag gccagctccg ccaagcagcg gctgaagtgc      600

gccagcctgc agaagttcgg cgagcgggcc tttaaggctt gggctgtggc ccggctgagc      660

cagagattcc ccaaggccga gtttgccgag gtgtccaagc tggtcaccga cctgaccaag      720

gtgcacaccg agtgttgtca cggcgacctg ctggaatgcg ccgacgacag agccgacctg      780

gccaagtaca tctgcgagaa ccaggacagc atcagcagca agctgaaaga gtgctgcgag      840

aagcccctgc tggaaaagag ccactgtatc gccgaggtgg aaaacgacga gatgcccgct      900

gacctgccca gcctggccgc cgacttcgtg gaaagcaagg acgtgtgcaa gaactacgcc      960

gaggccaagg atgtgttcct gggcatgttc ctgtatgagt acgcccgcag acaccccgac     1020

tacagcgtgg tgctgctgct gcggctggcc aagacctacg agacaaccct ggaaaagtgc     1080

tgcgccgctg ccgaccccca cgagtgctac gccaaggtgt tcgacgagtt caagcctctg     1140

gtggaagaac cccagaacct gatcaagcag aactgcgagc tgttcgagca gctgggcgag     1200

tacaagttcc agaacgccct gctcgtgcgg tacaccaaga aagtgcccca ggtgtccacc     1260

cccaccctgg tcgaagtgtc ccggaacctg ggcaaagtgg gcagcaagtg ctgcaagcac     1320

cctgaggcca agcggatgcc ctgcgccgag gactacctgt ccgtggtgct gaaccagctg     1380

tgcgtgctgc acgagaaaac ccccgtgtcc gacagagtga ccaagtgctg taccgagagc     1440

ctggtcaaca gacggccctg cttcagcgcc ctggaagtgg acgagacata cgtgcccaaa     1500

gagttcaacg ccgagacatt caccttccac gccgacatct gcaccctgag cgagaaagag     1560

cggcagatca agaagcagac cgccctggtc gagctggtca agcacaagcc caaggccacc     1620

aaagaacagc tgaaggccgt gatggacgac ttcgccgcct tcgtcgagaa gtgttgcaag     1680

gccgacgaca aagagacatg cttcgccgaa gagggcaaga aactggtggc cgcctctcag     1740

gccgccctgg gactgggatc tggcggcgga ggaagcggag gcggaggatc tgggggaggc     1800

ggctctggcg gagggggatc cgccagaaat ggcgaccact gtcccctggg ccctggccgg     1860

tgttgcagac tgcacacagt gcgggccagc ctggaagatc tgggctgggc cgattgggtg     1920

ctgagcccca gagaagtgca ggtcacaatg tgcatcggcg cctgccccag ccagttcaga     1980

gccgccaaca tgcacgccca gatcaagacc agcctgcacc ggctgaagcc cgacaccgtg     2040

cctgcccctt gttgcgtgcc cgccagctac aaccccatgg tgctgattca gaaaaccgac     2100

accggcgtgt ccctgcagac ctacgacgat ctgctggcca aggactgcca ctgcatc        2157


<210>  88
<211>  2157
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  fusion protein coding sequence

<400>  88
gatgcacaca agagtgaggt tgctcatcgg tttaaagatt tgggagaaga aaatttcaaa       60

gccttggtgt tgattgcctt tgctcagtat cttcagcagg ccccatttga agatcatgta      120

aaattagtga atgaagtaac tgaatttgca aaaacatgtg ttgctgatga gtcagctgaa      180

aattgtgaca aatcacttca tacccttttt ggagacaaat tatgcacagt tgcaactctt      240

cgtgaaacct atggtgaaat ggctgactgc tgtgcaaaac aagaacctga gagaaatgaa      300

tgcttcttgc aacacaaaga tgacaaccca aacctccccc gattggtgag accagaggtt      360

gatgtgatgt gcactgcttt tcatgacaat gaagagacat ttttgaaaaa atacttatat      420

gaaattgcca gaagacatcc ttacttttat gccccggaac tccttttctt tgctaaaagg      480

tataaagctg cttttacaga atgttgccaa gctgctgata aagctgcctg cctgttgcca      540

aagctcgatg aacttcggga tgaagggaag gcttcgtctg ccaaacagag actcaagtgt      600

gccagtctcc aaaaatttgg agaaagagct ttcaaagcat gggcagtagc tcgcctgagc      660

cagagatttc ccaaagctga gtttgcagaa gtttccaagt tagtgacaga tcttaccaaa      720

gtccacacgg aatgctgcca tggagatctg cttgaatgtg ctgatgacag ggcggacctt      780

gccaagtata tctgtgaaaa tcaagattcg atctccagta aactgaagga atgctgtgaa      840

aaacctctgt tggaaaaatc ccactgcatt gccgaagtgg aaaatgatga gatgcctgct      900

gacttgcctt cattagctgc tgattttgtt gaaagtaagg atgtttgcaa aaactatgct      960

gaggcaaagg atgtcttcct gggcatgttt ttgtatgaat atgcaagaag gcatcctgat     1020

tactctgtcg tgctgctgct gagacttgcc aagacatatg aaaccactct agagaagtgc     1080

tgtgccgctg cagatcctca tgaatgctat gccaaagtgt tcgatgaatt taaacctctt     1140

gtggaagagc ctcagaattt aatcaaacaa aattgtgagc tttttgagca gcttggagag     1200

tacaaattcc agaatgcgct attagttcgt tacaccaaga aagtacccca agtgtcaact     1260

ccaactcttg tagaggtctc aagaaaccta ggaaaagtgg gcagcaaatg ttgtaaacat     1320

cctgaagcaa aaagaatgcc ctgtgcagaa gactatctat ccgtggtcct gaaccagtta     1380

tgtgtgttgc atgagaaaac gccagtaagt gacagagtca ccaaatgctg cacagaatcc     1440

ttggtgaaca ggcgaccatg cttttcagct ctggaagtcg atgaaacata cgttcccaaa     1500

gagtttaatg ctgaaacatt caccttccat gcagatatat gcacactttc tgagaaggag     1560

agacaaatca agaaacaaac tgcacttgtt gagctcgtga aacacaagcc caaggcaaca     1620

aaagagcaac tgaaagctgt tatggatgat ttcgcagctt ttgtagagaa gtgctgcaag     1680

gctgacgata aggagacctg ctttgccgag gagggtaaaa aacttgttgc tgcaagtcaa     1740

gctgccttag gcttaggcag cggcggcggc ggcagcggcg gcggcggatc tggtggaggt     1800

ggcagtggag gagggggatc cgcgcgcaac ggggaccact gtccgctcgg gcccgggcgt     1860

tgctgccgtc tgcacacggt ccgcgcgtcg ctggaagacc tgggctgggc cgattgggtg     1920

ctgtcgccac gggaggtgca agtgaccatg tgcatcggcg cgtgcccgag ccagttccgg     1980

gcggcaaaca tgcacgcgca gatcaagacg agcctgcacc gcctgaagcc cgacacggtg     2040

ccagcgccct gctgcgtgcc cgccagctac aatcccatgg tgctcattca aaagaccgac     2100

accggggtgt cgctccagac ctatgatgac ttgttagcca aagactgcca ctgcata        2157


<210>  89
<211>  2151
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  fusion protein coding sequence

<400>  89
gatgcacaca agagtgaggt tgctcatcgg tttaaagatt tgggagaaga aaatttcaaa       60

gccttggtgt tgattgcctt tgctcagtat cttcagcagt ccccatttga agatcatgta      120

aaattagtga atgaagtaac tgaatttgca aaaacatgtg ttgctgatga gtcagctgaa      180

aattgtgaca aatcacttca tacccttttt ggagacaaat tatgcacagt tgcaactctt      240

cgtgaaacct atggtgaaat ggctgactgc tgtgcaaaac aagaacctga gagaaatgaa      300

tgcttcttgc aacacaaaga tgacaaccca aacctccccc gattggtgag accagaggtt      360

gatgtgatgt gcactgcttt tcatgacaat gaagagacat ttttgaaaaa atacttatat      420

gaaattgcca gaagacatcc ttacttttat gccccggaac tccttttctt tgctaaaagg      480

tataaagctg cttttacaga atgttgccaa gctgctgata aagctgcctg cctgttgcca      540

aagctcgatg aacttcggga tgaagggaag gcttcgtctg ccaaacagag actcaagtgt      600

gccagtctcc aaaaatttgg agaaagagct ttcaaagcat gggcagtagc tcgcctgagc      660

cagagatttc ccaaagctga gtttgcagaa gtttccaagt tagtgacaga tcttaccaaa      720

gtccacacgg aatgctgcca tggagatctg cttgaatgtg ctgatgacag ggcggacctt      780

gccaagtata tctgtgaaaa tcaagattcg atctccagta aactgaagga atgctgtgaa      840

aaacctctgt tggaaaaatc ccactgcatt gccgaagtgg aaaatgatga gatgcctgct      900

gacttgcctt cattagctgc tgattttgtt gaaagtaagg atgtttgcaa aaactatgct      960

gaggcaaagg atgtcttcct gggcatgttt ttgtatgaat atgcaagaag gcatcctgat     1020

tactctgtcg tgctgctgct gagacttgcc aagacatatg aaaccactct agagaagtgc     1080

tgtgccgctg cagatcctca tgaatgctat gccaaagtgt tcgatgaatt taaacctctt     1140

gtggaagagc ctcagaattt aatcaaacaa aattgtgagc tttttgagca gcttggagag     1200

tacaaattcc agaatgcgct attagttcgt tacaccaaga aagtacccca agtgtcaact     1260

ccaactcttg tagaggtctc aagaaaccta ggaaaagtgg gcagcaaatg ttgtaaacat     1320

cctgaagcaa aaagaatgcc ctgtgcagaa gactatctat ccgtggtcct gaaccagtta     1380

tgtgtgttgc atgagaaaac gccagtaagt gacagagtca ccaaatgctg cacagaatcc     1440

ttggtgaaca ggcgaccatg cttttcagct ctggaagtcg atgaaacata cgttcccaaa     1500

gagtttaatg ctgaaacatt caccttccat gcagatatat gcacactttc tgagaaggag     1560

agacaaatca agaaacaaac tgcacttgtt gagctcgtga aacacaagcc caaggcaaca     1620

aaagagcaac tgaaagctgt tatggatgat ttcgcagctt ttgtagagaa gtgctgcaag     1680

gctgacgata aggagacctg ctttgccgag gagggtaaaa aacttgttgc tgcaagtcaa     1740

gctgccttag gcttagcacc tgcccccgct ccagcacccg ccccagcccc tgctcccgca     1800

ccagctcctg caccagcgcg caacggggac cactgtccgc tcgggcccgg gcgttgctgc     1860

cgtctgcaca cggtccgcgc gtcgctggaa gacctgggct gggccgattg ggtgctgtcg     1920

ccacgggagg tgcaagtgac catgtgcatc ggcgcgtgcc cgagccagtt ccgggcggca     1980

aacatgcacg cgcagatcaa gacgagcctg caccgcctga agcccgacac ggtgccagcg     2040

ccctgctgcg tgcccgccag ctacaatccc atggtgctca ttcaaaagac cgacaccggg     2100

gtgtcgctcc agacctatga tgacttgtta gccaaagact gccactgcat a              2151


<210>  90
<211>  2217
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  fusion protein coding sequence

<400>  90
gatgcacaca agagtgaggt tgctcatcgg tttaaagatt tgggagaaga aaatttcaaa       60

gccttggtgt tgattgcctt tgctcagtat cttcagcagt ccccatttga agatcatgta      120

aaattagtga atgaagtaac tgaatttgca aaaacatgtg ttgctgatga gtcagctgaa      180

aattgtgaca aatcacttca tacccttttt ggagacaaat tatgcacagt tgcaactctt      240

cgtgaaacct atggtgaaat ggctgactgc tgtgcaaaac aagaacctga gagaaatgaa      300

tgcttcttgc aacacaaaga tgacaaccca aacctccccc gattggtgag accagaggtt      360

gatgtgatgt gcactgcttt tcatgacaat gaagagacat ttttgaaaaa atacttatat      420

gaaattgcca gaagacatcc ttacttttat gccccggaac tccttttctt tgctaaaagg      480

tataaagctg cttttacaga atgttgccaa gctgctgata aagctgcctg cctgttgcca      540

aagctcgatg aacttcggga tgaagggaag gcttcgtctg ccaaacagag actcaagtgt      600

gccagtctcc aaaaatttgg agaaagagct ttcaaagcat gggcagtagc tcgcctgagc      660

cagagatttc ccaaagctga gtttgcagaa gtttccaagt tagtgacaga tcttaccaaa      720

gtccacacgg aatgctgcca tggagatctg cttgaatgtg ctgatgacag ggcggacctt      780

gccaagtata tctgtgaaaa tcaagattcg atctccagta aactgaagga atgctgtgaa      840

aaacctctgt tggaaaaatc ccactgcatt gccgaagtgg aaaatgatga gatgcctgct      900

gacttgcctt cattagctgc tgattttgtt gaaagtaagg atgtttgcaa aaactatgct      960

gaggcaaagg atgtcttcct gggcatgttt ttgtatgaat atgcaagaag gcatcctgat     1020

tactctgtcg tgctgctgct gagacttgcc aagacatatg aaaccactct agagaagtgc     1080

tgtgccgctg cagatcctca tgaatgctat gccaaagtgt tcgatgaatt taaacctctt     1140

gtggaagagc ctcagaattt aatcaaacaa aattgtgagc tttttgagca gcttggagag     1200

tacaaattcc agaatgcgct attagttcgt tacaccaaga aagtacccca agtgtcaact     1260

ccaactcttg tagaggtctc aagaaaccta ggaaaagtgg gcagcaaatg ttgtaaacat     1320

cctgaagcaa aaagaatgcc ctgtgcagaa gactatctat ccgtggtcct gaaccagtta     1380

tgtgtgttgc atgagaaaac gccagtaagt gacagagtca ccaaatgctg cacagaatcc     1440

ttggtgaaca ggcgaccatg cttttcagct ctggaagtcg atgaaacata cgttcccaaa     1500

gagtttaatg ctgaaacatt caccttccat gcagatatat gcacactttc tgagaaggag     1560

agacaaatca agaaacaaac tgcacttgtt gagctcgtga aacacaagcc caaggcaaca     1620

aaagagcaac tgaaagctgt tatggatgat ttcgcagctt ttgtagagaa gtgctgcaag     1680

gctgacgata aggagacctg ctttgccgag gagggtaaaa aacttgttgc tgcaagtcaa     1740

gctgccttag gcttaggcag cggcggcggc ggcagcggcg gcggcggatc tggtggaggt     1800

ggcagtggag gagggggatc cggcggcggc ggcagcggcg gcggcggatc tggtggaggt     1860

ggcagtggag gagggggatc cgcgcgcaac ggggaccact gtccgctcgg gcccgggcgt     1920

tgctgccgtc tgcacacggt ccgcgcgtcg ctggaagacc tgggctgggc cgattgggtg     1980

ctgtcgccac gggaggtgca agtgaccatg tgcatcggcg cgtgcccgag ccagttccgg     2040

gcggcaaaca tgcacgcgca gatcaagacg agcctgcacc gcctgaagcc cgacacggtg     2100

ccagcgccct gctgcgtgcc cgccagctac aatcccatgg tgctcattca aaagaccgac     2160

accggggtgt cgctccagac ctatgatgac ttgttagcca aagactgcca ctgcata        2217


<210>  91
<211>  2157
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  fusion protein coding sequence

<400>  91
gacgcccaca agagcgaggt ggcccaccgg ttcaaggacc tgggcgagga gaacttcaag       60

gccctggtgc tgatcgcctt cgcccagtac ctgcagcagt cccccttcga ggaccacgtg      120

aagctggtga acgaggtgac cgagttcgcc aagacctgcg tggccgacga gagcgccgag      180

aactgcgaca agagcctgca caccctgttc ggcgacaagc tgtgcaccgt ggccaccctg      240

cgggagacct acggcgagat ggccgactgc tgcgccaagc aggagcccga gcggaacgag      300

tgcttcctgc agcacaagga cgacaacccc aacctgcccc ggctggtgcg gcccgaggtg      360

gacgtgatgt gcaccgcctt ccacgacaac gaggagacct tcctgaagaa gtacctgtac      420

gagatcgccc ggcggcaccc ctacttctac gcccccgagc tgctgttctt cgccaagcgg      480

tacaaggccg ccttcaccga gtgctgccag gccgccgaca aggccgcctg cctgctgccc      540

aagctggacg agctgcggga cgagggcaag gccagcagcg ccaagcagcg gctgaagtgc      600

gccagcctgc agaagttcgg cgagcgggcc ttcaaggcct gggccgtggc ccggctgagc      660

cagcggttcc ccaaggccga gttcgccgag gtgagcaagc tggtgaccga cctgaccaag      720

gtgcacaccg agtgctgcca cggcgacctg ctggagtgcg ccgacgaccg ggccgacctg      780

gccaagtaca tctgcgagaa ccaggacagc atcagcagca agctgaagga gtgctgcgag      840

aagcccctgc tggagaagag ccactgcatc gccgaggtgg agaacgacga gatgcccgcc      900

gacctgccca gcctggccgc cgacttcgtg gagagcaagg acgtgtgcaa gaactacgcc      960

gaggccaagg acgtgttcct gggcatgttc ctgtacgagt acgcccggcg gcaccccgac     1020

tacagcgtgg tgctgctgct gcggctggcc aagacctacg agaccaccct ggagaagtgc     1080

tgcgccgccg ccgaccccca cgagtgctac gccaaggtgt tcgacgagtt caagcccctg     1140

gtggaggagc cccagaacct gatcaagcag aactgcgagc tgttcgagca gctgggcgag     1200

tacaagttcc agaacgccct gctggtgcgg tacaccaaga aggtgcccca ggtgagcacc     1260

cccaccctgg tggaggtgag ccggaacctg ggcaaggtgg gcagcaagtg ctgcaagcac     1320

cccgaggcca agcggatgcc ctgcgccgag gactacctga gcgtggtgct gaaccagctg     1380

tgcgtgctgc acgagaagac ccccgtgagc gaccgggtga ccaagtgctg caccgagagc     1440

ctggtgaacc ggcggccctg cttcagcgcc ctggaggtgg acgagaccta cgtgcccaag     1500

gagttcaacg ccgagacctt caccttccac gccgacatct gcaccctgag cgagaaggag     1560

cggcagatca agaagcagac cgccctggtg gagctggtga agcacaagcc caaggccacc     1620

aaggagcagc tgaaggccgt gatggacgac ttcgccgcct tcgtggagaa gtgctgcaag     1680

gccgacgaca aggagacctg cttcgccgag gagggcaaga agctggtggc cgccagccag     1740

gccgccctgg gcctgggcag cggcggcggc ggcagcggcg gcggcggatc tggtggaggt     1800

ggcagtggag gagggggatc cgctcgcaac ggtgaccact gccctctggg tcctggtcgc     1860

tgctgccgcc tgcacaccgt tcgcgcttct ctggaagacc tgggttgggc tgactgggtt     1920

ctgtctcctc gcgaagttca ggttaccatg tgcatcggtg cttgcccttc tcagttccgc     1980

gctgctaaca tgcacgcttg gatcaaaacc tctctgcacc gcctgaaacc tgacaccgtt     2040

cctgctcctt gctgcgttcc tgcttcttac aaccctatgg ttctgatcca gaaaaccgac     2100

accggtgttt ctctgcagac ctacgacgac ctgctggcta aagactgcca ctgcatc        2157


<210>  92
<211>  735
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fusion protein coding sequence

<400>  92

Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu 
1               5                   10                  15      


Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln 
            20                  25                  30          


Gln Ser Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr Glu 
        35                  40                  45              


Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys 
    50                  55                  60                  


Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu 
65                  70                  75                  80  


Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro 
                85                  90                  95      


Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu 
            100                 105                 110         


Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe His 
        115                 120                 125             


Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg 
    130                 135                 140                 


Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg 
145                 150                 155                 160 


Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala 
                165                 170                 175     


Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser 
            180                 185                 190         


Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu 
        195                 200                 205             


Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro 
    210                 215                 220                 


Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys 
225                 230                 235                 240 


Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp 
                245                 250                 255     


Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser 
            260                 265                 270         


Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His 
        275                 280                 285             


Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser 
    290                 295                 300                 


Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala 
305                 310                 315                 320 


Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg 
                325                 330                 335     


Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys Thr 
            340                 345                 350         


Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His Glu 
        355                 360                 365             


Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro 
    370                 375                 380                 


Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu 
385                 390                 395                 400 


Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro 
                405                 410                 415     


Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly Lys 
            420                 425                 430         


Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys 
        435                 440                 445             


Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu His 
    450                 455                 460                 


Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser 
465                 470                 475                 480 


Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr 
                485                 490                 495     


Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala Asp 
            500                 505                 510         


Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala 
        515                 520                 525             


Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln Leu 
    530                 535                 540                 


Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys Lys 
545                 550                 555                 560 


Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu Val 
                565                 570                 575     


Ala Ala Ser Gln Ala Ala Leu Gly Leu Gly Ser Gly Gly Gly Gly Ser 
            580                 585                 590         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        595                 600                 605             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    610                 615                 620                 


Gly Gly Ser Asp His Cys Pro Leu Gly Pro Gly Arg Cys Cys Arg Leu 
625                 630                 635                 640 


His Thr Val Arg Ala Ser Leu Glu Asp Leu Gly Trp Ala Asp Trp Val 
                645                 650                 655     


Leu Ser Pro Arg Glu Val Gln Val Thr Met Cys Ile Gly Ala Cys Pro 
            660                 665                 670         


Ser Gln Phe Arg Ala Ala Asn Met His Ala Gln Ile Lys Thr Ser Leu 
        675                 680                 685             


His Arg Leu Lys Pro Asp Thr Val Pro Ala Pro Cys Cys Val Pro Ala 
    690                 695                 700                 


Ser Tyr Asn Pro Met Val Leu Ile Gln Lys Thr Asp Thr Gly Val Ser 
705                 710                 715                 720 


Leu Gln Thr Tyr Asp Asp Leu Leu Ala Lys Asp Cys His Cys Ile 
                725                 730                 735 


<210>  93
<211>  734
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fusion protein coding sequence

<400>  93

Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu 
1               5                   10                  15      


Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln 
            20                  25                  30          


Gln Ser Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr Glu 
        35                  40                  45              


Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys 
    50                  55                  60                  


Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu 
65                  70                  75                  80  


Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro 
                85                  90                  95      


Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu 
            100                 105                 110         


Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe His 
        115                 120                 125             


Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg 
    130                 135                 140                 


Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg 
145                 150                 155                 160 


Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala 
                165                 170                 175     


Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser 
            180                 185                 190         


Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu 
        195                 200                 205             


Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro 
    210                 215                 220                 


Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys 
225                 230                 235                 240 


Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp 
                245                 250                 255     


Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser 
            260                 265                 270         


Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His 
        275                 280                 285             


Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser 
    290                 295                 300                 


Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala 
305                 310                 315                 320 


Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg 
                325                 330                 335     


Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys Thr 
            340                 345                 350         


Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His Glu 
        355                 360                 365             


Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro 
    370                 375                 380                 


Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu 
385                 390                 395                 400 


Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro 
                405                 410                 415     


Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly Lys 
            420                 425                 430         


Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys 
        435                 440                 445             


Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu His 
    450                 455                 460                 


Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser 
465                 470                 475                 480 


Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr 
                485                 490                 495     


Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala Asp 
            500                 505                 510         


Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala 
        515                 520                 525             


Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln Leu 
    530                 535                 540                 


Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys Lys 
545                 550                 555                 560 


Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu Val 
                565                 570                 575     


Ala Ala Ser Gln Ala Ala Leu Gly Leu Gly Ser Gly Gly Gly Gly Ser 
            580                 585                 590         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        595                 600                 605             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    610                 615                 620                 


Gly Gly Ser His Cys Pro Leu Gly Pro Gly Arg Cys Cys Arg Leu His 
625                 630                 635                 640 


Thr Val Arg Ala Ser Leu Glu Asp Leu Gly Trp Ala Asp Trp Val Leu 
                645                 650                 655     


Ser Pro Arg Glu Val Gln Val Thr Met Cys Ile Gly Ala Cys Pro Ser 
            660                 665                 670         


Gln Phe Arg Ala Ala Asn Met His Ala Gln Ile Lys Thr Ser Leu His 
        675                 680                 685             


Arg Leu Lys Pro Asp Thr Val Pro Ala Pro Cys Cys Val Pro Ala Ser 
    690                 695                 700                 


Tyr Asn Pro Met Val Leu Ile Gln Lys Thr Asp Thr Gly Val Ser Leu 
705                 710                 715                 720 


Gln Thr Tyr Asp Asp Leu Leu Ala Lys Asp Cys His Cys Ile 
                725                 730                 


<210>  94
<211>  735
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fusion protein coding sequence

<400>  94

Glu Phe His His His His His His Asp Ala His Lys Ser Glu Val Ala 
1               5                   10                  15      


His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu Val Leu 
            20                  25                  30          


Ile Ala Phe Ala Gln Tyr Leu Gln Gln Ser Pro Phe Glu Asp His Val 
        35                  40                  45              


Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val Ala Asp 
    50                  55                  60                  


Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe Gly Asp 
65                  70                  75                  80  


Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu Met Ala 
                85                  90                  95      


Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe Leu Gln 
            100                 105                 110         


His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro Glu Val 
        115                 120                 125             


Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe Leu Lys 
    130                 135                 140                 


Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr Ala Pro 
145                 150                 155                 160 


Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr Glu Cys 
                165                 170                 175     


Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu Asp Glu 
            180                 185                 190         


Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu Lys Cys 
        195                 200                 205             


Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp Ala Val 
    210                 215                 220                 


Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu Val Ser 
225                 230                 235                 240 


Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys His Gly 
                245                 250                 255     


Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys Tyr Ile 
            260                 265                 270         


Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys Cys Glu 
        275                 280                 285             


Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu Asn Asp 
    290                 295                 300                 


Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val Glu Ser 
305                 310                 315                 320 


Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe Leu Gly 
                325                 330                 335     


Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser Val Val 
            340                 345                 350         


Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu Lys Cys 
        355                 360                 365             


Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe Asp Glu 
    370                 375                 380                 


Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln Asn Cys 
385                 390                 395                 400 


Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala Leu Leu 
                405                 410                 415     


Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr Leu Val 
            420                 425                 430         


Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys Lys His 
        435                 440                 445             


Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser Val Val 
    450                 455                 460                 


Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser Asp Arg 
465                 470                 475                 480 


Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro Cys Phe 
                485                 490                 495     


Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe Asn Ala 
            500                 505                 510         


Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu Lys Glu 
        515                 520                 525             


Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys His Lys 
    530                 535                 540                 


Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp Phe Ala 
545                 550                 555                 560 


Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr Cys Phe 
                565                 570                 575     


Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala Leu Gly 
            580                 585                 590         


Leu Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        595                 600                 605             


Gly Ser Gly Gly Gly Gly Ser Leu Glu Val Leu Phe Gln Gly Pro Ala 
    610                 615                 620                 


Arg Asn Gly Asp His Cys Pro Leu Gly Pro Gly Arg Cys Cys Arg Leu 
625                 630                 635                 640 


His Thr Val Arg Ala Ser Leu Glu Asp Leu Gly Trp Ala Asp Trp Val 
                645                 650                 655     


Leu Ser Pro Arg Glu Val Gln Val Thr Met Cys Ile Gly Ala Cys Pro 
            660                 665                 670         


Ser Gln Phe Arg Ala Ala Asn Met His Ala Gln Ile Lys Thr Ser Leu 
        675                 680                 685             


His Arg Leu Lys Pro Asp Thr Val Pro Ala Pro Cys Cys Val Pro Ala 
    690                 695                 700                 


Ser Tyr Asn Pro Met Val Leu Ile Gln Lys Thr Asp Thr Gly Val Ser 
705                 710                 715                 720 


Leu Gln Thr Tyr Asp Asp Leu Leu Ala Lys Asp Cys His Cys Ile 
                725                 730                 735 


<210>  95
<211>  2205
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  fusion protein coding sequence

<400>  95
gatgcacaca agagtgaggt tgctcatcgg tttaaagatt tgggagaaga aaatttcaaa       60

gccttggtgt tgattgcctt tgctcagtat cttcagcagt ccccatttga agatcatgta      120

aaattagtga atgaagtaac tgaatttgca aaaacatgtg ttgctgatga gtcagctgaa      180

aattgtgaca aatcacttca tacccttttt ggagacaaat tatgcacagt tgcaactctt      240

cgtgaaacct atggtgaaat ggctgactgc tgtgcaaaac aagaacctga gagaaatgaa      300

tgcttcttgc aacacaaaga tgacaaccca aacctccccc gattggtgag accagaggtt      360

gatgtgatgt gcactgcttt tcatgacaat gaagagacat ttttgaaaaa atacttatat      420

gaaattgcca gaagacatcc ttacttttat gccccggaac tccttttctt tgctaaaagg      480

tataaagctg cttttacaga atgttgccaa gctgctgata aagctgcctg cctgttgcca      540

aagctcgatg aacttcggga tgaagggaag gcttcgtctg ccaaacagag actcaagtgt      600

gccagtctcc aaaaatttgg agaaagagct ttcaaagcat gggcagtagc tcgcctgagc      660

cagagatttc ccaaagctga gtttgcagaa gtttccaagt tagtgacaga tcttaccaaa      720

gtccacacgg aatgctgcca tggagatctg cttgaatgtg ctgatgacag ggcggacctt      780

gccaagtata tctgtgaaaa tcaagattcg atctccagta aactgaagga atgctgtgaa      840

aaacctctgt tggaaaaatc ccactgcatt gccgaagtgg aaaatgatga gatgcctgct      900

gacttgcctt cattagctgc tgattttgtt gaaagtaagg atgtttgcaa aaactatgct      960

gaggcaaagg atgtcttcct gggcatgttt ttgtatgaat atgcaagaag gcatcctgat     1020

tactctgtcg tgctgctgct gagacttgcc aagacatatg aaaccactct agagaagtgc     1080

tgtgccgctg cagatcctca tgaatgctat gccaaagtgt tcgatgaatt taaacctctt     1140

gtggaagagc ctcagaattt aatcaaacaa aattgtgagc tttttgagca gcttggagag     1200

tacaaattcc agaatgcgct attagttcgt tacaccaaga aagtacccca agtgtcaact     1260

ccaactcttg tagaggtctc aagaaaccta ggaaaagtgg gcagcaaatg ttgtaaacat     1320

cctgaagcaa aaagaatgcc ctgtgcagaa gactatctat ccgtggtcct gaaccagtta     1380

tgtgtgttgc atgagaaaac gccagtaagt gacagagtca ccaaatgctg cacagaatcc     1440

ttggtgaaca ggcgaccatg cttttcagct ctggaagtcg atgaaacata cgttcccaaa     1500

gagtttaatg ctgaaacatt caccttccat gcagatatat gcacactttc tgagaaggag     1560

agacaaatca agaaacaaac tgcacttgtt gagctcgtga aacacaagcc caaggcaaca     1620

aaagagcaac tgaaagctgt tatggatgat ttcgcagctt ttgtagagaa gtgctgcaag     1680

gctgacgata aggagacctg ctttgccgag gagggtaaaa aacttgttgc tgcaagtcaa     1740

gctgccttag ggcttggaag cggcggaggg gggagtggcg gcggtggctc cggggggggc     1800

ggatccggcg gagggggcag cgggggtgga gggagtggcg ggggaggatc agggggagga     1860

ggatcaggag ggggcggaag tgatcattgc cctctcgggc ccggacggtg ttgccgcctc     1920

cacactgtga gggcttcact tgaagacctt ggatgggccg actgggtgct gtccccaaga     1980

gaggtacaag tcacaatgtg tattggcgcc tgccccagcc agtttcgcgc cgctaacatg     2040

cacgcccaga taaaaaccag cctgcaccgc ctgaagcccg acacggtgcc agcgccctgc     2100

tgcgtgcccg ccagctacaa tcccatggtg ctcattcaaa agaccgacac cggggtgtcg     2160

ctccagacct atgatgactt gttagccaaa gactgccact gcata                     2205


<210>  96
<211>  327
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  GDF15 variant

<400>  96
ggggaccact gtccgctcgg gcccgggcgt tgctgccgtc tgcacacggt ccgcgcgtcg       60

ctggaagacc tgggctgggc cgattgggtg ctgtcgccac gggaggtgca agtgaccatg      120

tgcatcggcg cgtgcccgag ccagttccgg gcggcaaaca tgcacgcgca gatcaagacg      180

agcctgcacc gcctgaagcc cgacacggtg ccagcgccct gctgcgtgcc cgccagctac      240

aatcccatgg tgctcattca aaagaccgac accggggtgt cgctccagac ctatgatgac      300

ttgttagcca aagactgcca ctgcata                                          327


<210>  97
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  GDF15 variant

<400>  97
gaccactgtc cgctcgggcc cgggcgttgc tgccgtctgc acacggtccg cgcgtcgctg       60

gaagacctgg gctgggccga ttgggtgctg tcgccacggg aggtgcaagt gaccatgtgc      120

atcggcgcgt gcccgagcca gttccgggcg gcaaacatgc acgcgcagat caagacgagc      180

ctgcaccgcc tgaagcccga cacggtgcca gcgccctgct gcgtgcccgc cagctacaat      240

cccatggtgc tcattcaaaa gaccgacacc ggggtgtcgc tccagaccta tgatgacttg      300

ttagccaaag actgccactg cata                                             324


<210>  98
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  GDF15 variant

<400>  98
gatcattgcc ctctcgggcc cggacggtgt tgccgcctcc acactgtgag ggcttcactt       60

gaagaccttg gatgggccga ctgggtgctg tccccaagag aggtacaagt cacaatgtgt      120

attggcgcct gccccagcca gtttcgcgcc gctaacatgc acgcccagat aaaaaccagc      180

ctgcaccgcc tgaagcccga cacggtgcca gcgccctgct gcgtgcccgc cagctacaat      240

cccatggtgc tcattcaaaa gaccgacacc ggggtgtcgc tccagaccta tgatgacttg      300

ttagccaaag actgccactg cata                                             324


<210>  99
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  GDF15 variant

<400>  99
gatcattgtc cccttggacc gggtagatgc tgtcgcctgc acactgtgcg ggcttcactg       60

gaggacctcg gctgggctga ctgggtgctg tccccacggg aggtgcaagt gaccatgtgc      120

atcggcgcct gtccttcgca attccgggcc gcgaatatgc acgcccagat caagacctcc      180

ctgcatcgcc tcaagcccga cactgtgcct gctccatgct gtgtgccggc ctcctataac      240

cccatggtgc tgatccagaa aaccgatacc ggcgtcagcc tgcagacgta tgatgatctg      300

ctggccaagg actgccattg catc                                             324


<210>  100
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  GDF15 variant

<400>  100
cactgtccgc tcgggcccgg gcgttgctgc cgtctgcaca cggtccgcgc gtcgctggaa       60

gacctgggct gggccgattg ggtgctgtcg ccacgggagg tgcaagtgac catgtgcatc      120

ggcgcgtgcc cgagccagtt ccgggcggca aacatgcacg cgcagatcaa gacgagcctg      180

caccgcctga agcccgacac ggtgccagcg ccctgctgcg tgcccgccag ctacaatccc      240

atggtgctca ttcaaaagac cgacaccggg gtgtcgctcc agacctatga tgacttgtta      300

gccaaagact gccactgcat a                                                321


<210>  101
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  GDF15 variant

<400>  101
cattgccctc tcgggcccgg acggtgttgc cgcctccaca ctgtgagggc ttcacttgaa       60

gaccttggat gggccgactg ggtgctgtcc ccaagagagg tacaagtcac aatgtgtatt      120

ggcgcctgcc ccagccagtt tcgcgccgct aacatgcacg cccagataaa aaccagcctg      180

caccgcctga agcccgacac ggtgccagcg ccctgctgcg tgcccgccag ctacaatccc      240

atggtgctca ttcaaaagac cgacaccggg gtgtcgctcc agacctatga tgacttgtta      300

gccaaagact gccactgcat a                                                321


<210>  102
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  GDF15 variant

<400>  102
cattgtcccc ttggaccggg tagatgctgt cgcctgcaca ctgtgcgggc ttcactggag       60

gacctcggct gggctgactg ggtgctgtcc ccacgggagg tgcaagtgac catgtgcatc      120

ggcgcctgtc cttcgcaatt ccgggccgcg aatatgcacg cccagatcaa gacctccctg      180

catcgcctca agcccgacac tgtgcctgct ccatgctgtg tgccggcctc ctataacccc      240

atggtgctga tccagaaaac cgataccggc gtcagcctgc agacgtatga tgatctgctg      300

gccaaggact gccattgcat c                                                321


<210>  103
<211>  318
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  GDF15 variant

<400>  103
tgtccgctcg ggcccgggcg ttgctgccgt ctgcacacgg tccgcgcgtc gctggaagac       60

ctgggctggg ccgattgggt gctgtcgcca cgggaggtgc aagtgaccat gtgcatcggc      120

gcgtgcccga gccagttccg ggcggcaaac atgcacgcgc agatcaagac gagcctgcac      180

cgcctgaagc ccgacacggt gccagcgccc tgctgcgtgc ccgccagcta caatcccatg      240

gtgctcattc aaaagaccga caccggggtg tcgctccaga cctatgatga cttgttagcc      300

aaagactgcc actgcata                                                    318


<210>  104
<211>  318
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  GDF15 variant

<400>  104
tgccctctcg ggcccggacg gtgttgccgc ctccacactg tgagggcttc acttgaagac       60

cttggatggg ccgactgggt gctgtcccca agagaggtac aagtcacaat gtgtattggc      120

gcctgcccca gccagtttcg cgccgctaac atgcacgccc agataaaaac cagcctgcac      180

cgcctgaagc ccgacacggt gccagcgccc tgctgcgtgc ccgccagcta caatcccatg      240

gtgctcattc aaaagaccga caccggggtg tcgctccaga cctatgatga cttgttagcc      300

aaagactgcc actgcata                                                    318


<210>  105
<211>  318
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  GDF15 variant

<400>  105
tgtccccttg gaccgggtag atgctgtcgc ctgcacactg tgcgggcttc actggaggac       60

ctcggctggg ctgactgggt gctgtcccca cgggaggtgc aagtgaccat gtgcatcggc      120

gcctgtcctt cgcaattccg ggccgcgaat atgcacgccc agatcaagac ctccctgcat      180

cgcctcaagc ccgacactgt gcctgctcca tgctgtgtgc cggcctccta taaccccatg      240

gtgctgatcc agaaaaccga taccggcgtc agcctgcaga cgtatgatga tctgctggcc      300

aaggactgcc attgcatc                                                    318


<210>  106
<211>  294
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  GDF15 variant

<400>  106
tgccgtctgc acacggtccg cgcgtcgctg gaagacctgg gctgggccga ttgggtgctg       60

tcgccacggg aggtgcaagt gaccatgtgc atcggcgcgt gcccgagcca gttccgggcg      120

gcaaacatgc acgcgcagat caagacgagc ctgcaccgcc tgaagcccga cacggtgcca      180

gcgccctgct gcgtgcccgc cagctacaat cccatggtgc tcattcaaaa gaccgacacc      240

ggggtgtcgc tccagaccta tgatgacttg ttagccaaag actgccactg cata            294


<210>  107
<211>  294
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  GDF15 variant

<400>  107
tgccgcctcc acactgtgag ggcttcactt gaagaccttg gatgggccga ctgggtgctg       60

tccccaagag aggtacaagt cacaatgtgt attggcgcct gccccagcca gtttcgcgcc      120

gctaacatgc acgcccagat aaaaaccagc ctgcaccgcc tgaagcccga cacggtgcca      180

gcgccctgct gcgtgcccgc cagctacaat cccatggtgc tcattcaaaa gaccgacacc      240

ggggtgtcgc tccagaccta tgatgacttg ttagccaaag actgccactg cata            294


<210>  108
<211>  294
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  GDF15 variant

<400>  108
tgtcgcctgc acactgtgcg ggcttcactg gaggacctcg gctgggctga ctgggtgctg       60

tccccacggg aggtgcaagt gaccatgtgc atcggcgcct gtccttcgca attccgggcc      120

gcgaatatgc acgcccagat caagacctcc ctgcatcgcc tcaagcccga cactgtgcct      180

gctccatgct gtgtgccggc ctcctataac cccatggtgc tgatccagaa aaccgatacc      240

ggcgtcagcc tgcagacgta tgatgatctg ctggccaagg actgccattg catc            294


<210>  109
<211>  2217
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  fusion protein coding sequence

<400>  109
gatgcgcaca agtcggaagt ggcccatcgc tttaaggacc tgggagaaga gaacttcaag       60

gccctggtcc tgatcgcgtt cgcccagtac ctccagcagt ccccgtttga ggaccacgtc      120

aagcttgtga acgaagtgac cgagttcgca aagacttgtg tggccgatga gtccgccgaa      180

aactgcgaca agtccctgca caccttgttc ggagacaagc tgtgcaccgt cgcgactttg      240

cgggagactt acggcgaaat ggcggactgc tgcgcaaagc aggagcccga aaggaacgag      300

tgcttcctgc aacacaagga cgacaacccg aaccttccga gactcgtgcg gcctgaggtc      360

gacgtgatgt gcactgcatt ccatgataac gaagaaacat tcctgaagaa gtacctgtat      420

gaaattgcca gacgccaccc gtacttctac gcccccgaac tgctgttctt cgccaagaga      480

tacaaggccg cctttaccga atgttgtcaa gccgccgata aggcagcgtg cctgctgccg      540

aagttggacg agctcaggga cgaaggaaag gcctcgtccg ccaagcagag gctgaagtgc      600

gcgtcgctcc agaagtttgg agagcgggct tttaaggcct gggcagtggc taggttgagc      660

cagaggttcc ccaaggcgga gtttgccgaa gtgtccaagc tcgtgactga cctgactaaa      720

gtccataccg aatgctgcca cggcgatctg ctcgaatgcg cagatgaccg ggcggatttg      780

gccaagtaca tttgcgaaaa ccaagactcc ataagctcca agctgaagga gtgctgtgaa      840

aagcctctgc tcgagaagtc ccactgtatc gccgaggtgg agaacgacga aatgccggca      900

gacctcccta gcctggcagc cgacttcgtc gaatccaagg acgtgtgcaa gaactacgcc      960

gaagcgaagg acgtgttcct gggaatgttc ctgtacgagt acgccagacg gcatccagac     1020

tactccgtgg tgcttctctt gcggctggcc aagacttatg aaacgaccct ggagaaatgt     1080

tgcgctgctg ctgacccaca cgagtgctac gccaaagtgt tcgacgagtt taagcctctc     1140

gtggaggaac cccagaacct catcaagcag aactgcgaac ttttcgagca gctcggggag     1200

tacaagttcc aaaacgcgct gcttgtccgc tacaccaaga aagtgccgca agtgtccaca     1260

ccgaccctcg tggaagtgtc caggaacctg ggcaaagtcg gaagcaaatg ttgcaagcac     1320

cccgaagcca agcgcatgcc gtgcgcagag gactaccttt cggtggtgtt gaaccagctc     1380

tgcgtcctgc acgaaaagac cccggtgtca gaccgcgtga ccaagtgctg taccgaaagc     1440

ctcgtgaatc ggcgcccctg cttctcggcc ctggaggtgg acgaaactta cgtgccgaaa     1500

gagttcaacg cggaaacctt cacctttcat gccgatatct gcaccctgtc cgagaaggag     1560

cggcagatca agaagcagac cgccctggtg gagcttgtga aacacaagcc gaaggccact     1620

aaggaacagc tgaaggccgt catggacgat ttcgctgcct tcgtcgagaa gtgctgcaag     1680

gccgacgaca aggagacttg cttcgctgaa gaagggaaga agcttgtggc cgctagccag     1740

gctgcactgg gactgggtag cggtggaggg ggatcagggg gtggtggatc gggaggagga     1800

ggatcaggag gtggcggctc aggaggaggc ggatcaggcg gtggaggatc cggaggcgga     1860

ggatcgggtg gaggaggctc agcgaggaac ggggatcatt gtccccttgg accgggtaga     1920

tgctgtcgcc tgcacactgt gcgggcttca ctggaggacc tcggctgggc tgactgggtg     1980

ctgtccccac gggaggtgca agtgaccatg tgcatcggcg cctgtccttc gcaattccgg     2040

gccgcgaata tgcacgccca gatcaagacc tccctgcatc gcctcaagcc cgacactgtg     2100

cctgctccat gctgtgtgcc ggcctcctat aaccccatgg tgctgatcca gaaaaccgat     2160

accggcgtca gcctgcagac gtatgatgat ctgctggcca aggactgcca ttgcatc        2217


<210>  110
<211>  2205
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  fusion protein coding sequence

<400>  110
gatgcgcaca agtcggaagt ggcccatcgc tttaaggacc tgggagaaga gaacttcaag       60

gccctggtcc tgatcgcgtt cgcccagtac ctccagcagt ccccgtttga ggaccacgtc      120

aagcttgtga acgaagtgac cgagttcgca aagacttgtg tggccgatga gtccgccgaa      180

aactgcgaca agtccctgca caccttgttc ggagacaagc tgtgcaccgt cgcgactttg      240

cgggagactt acggcgaaat ggcggactgc tgcgcaaagc aggagcccga aaggaacgag      300

tgcttcctgc aacacaagga cgacaacccg aaccttccga gactcgtgcg gcctgaggtc      360

gacgtgatgt gcactgcatt ccatgataac gaagaaacat tcctgaagaa gtacctgtat      420

gaaattgcca gacgccaccc gtacttctac gcccccgaac tgctgttctt cgccaagaga      480

tacaaggccg cctttaccga atgttgtcaa gccgccgata aggcagcgtg cctgctgccg      540

aagttggacg agctcaggga cgaaggaaag gcctcgtccg ccaagcagag gctgaagtgc      600

gcgtcgctcc agaagtttgg agagcgggct tttaaggcct gggcagtggc taggttgagc      660

cagaggttcc ccaaggcgga gtttgccgaa gtgtccaagc tcgtgactga cctgactaaa      720

gtccataccg aatgctgcca cggcgatctg ctcgaatgcg cagatgaccg ggcggatttg      780

gccaagtaca tttgcgaaaa ccaagactcc ataagctcca agctgaagga gtgctgtgaa      840

aagcctctgc tcgagaagtc ccactgtatc gccgaggtgg agaacgacga aatgccggca      900

gacctcccta gcctggcagc cgacttcgtc gaatccaagg acgtgtgcaa gaactacgcc      960

gaagcgaagg acgtgttcct gggaatgttc ctgtacgagt acgccagacg gcatccagac     1020

tactccgtgg tgcttctctt gcggctggcc aagacttatg aaacgaccct ggagaaatgt     1080

tgcgctgctg ctgacccaca cgagtgctac gccaaagtgt tcgacgagtt taagcctctc     1140

gtggaggaac cccagaacct catcaagcag aactgcgaac ttttcgagca gctcggggag     1200

tacaagttcc aaaacgcgct gcttgtccgc tacaccaaga aagtgccgca agtgtccaca     1260

ccgaccctcg tggaagtgtc caggaacctg ggcaaagtcg gaagcaaatg ttgcaagcac     1320

cccgaagcca agcgcatgcc gtgcgcagag gactaccttt cggtggtgtt gaaccagctc     1380

tgcgtcctgc acgaaaagac cccggtgtca gaccgcgtga ccaagtgctg taccgaaagc     1440

ctcgtgaatc ggcgcccctg cttctcggcc ctggaggtgg acgaaactta cgtgccgaaa     1500

gagttcaacg cggaaacctt cacctttcat gccgatatct gcaccctgtc cgagaaggag     1560

cggcagatca agaagcagac cgccctggtg gagcttgtga aacacaagcc gaaggccact     1620

aaggaacagc tgaaggccgt catggacgat ttcgctgcct tcgtcgagaa gtgctgcaag     1680

gccgacgaca aggagacttg cttcgctgaa gaagggaaga agcttgtggc cgctagccag     1740

gctgcactgg gactgggtag cggtggaggg ggatcagggg gtggtggatc gggaggagga     1800

ggatcaggag gtggcggctc aggaggaggc ggatcaggcg gtggaggatc cggaggcgga     1860

ggatcgggtg gaggaggctc agatcattgt ccccttggac cgggtagatg ctgtcgcctg     1920

cacactgtgc gggcttcact ggaggacctc ggctgggctg actgggtgct gtccccacgg     1980

gaggtgcaag tgaccatgtg catcggcgcc tgtccttcgc aattccgggc cgcgaatatg     2040

cacgcccaga tcaagacctc cctgcatcgc ctcaagcccg acactgtgcc tgctccatgc     2100

tgtgtgccgg cctcctataa ccccatggtg ctgatccaga aaaccgatac cggcgtcagc     2160

ctgcagacgt atgatgatct gctggccaag gactgccatt gcatc                     2205


<210>  111
<211>  734
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fusion protein

<400>  111

Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu 
1               5                   10                  15      


Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln 
            20                  25                  30          


Gln Ser Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr Glu 
        35                  40                  45              


Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys 
    50                  55                  60                  


Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu 
65                  70                  75                  80  


Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro 
                85                  90                  95      


Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu 
            100                 105                 110         


Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe His 
        115                 120                 125             


Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg 
    130                 135                 140                 


Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg 
145                 150                 155                 160 


Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala 
                165                 170                 175     


Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser 
            180                 185                 190         


Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu 
        195                 200                 205             


Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro 
    210                 215                 220                 


Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys 
225                 230                 235                 240 


Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp 
                245                 250                 255     


Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser 
            260                 265                 270         


Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His 
        275                 280                 285             


Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser 
    290                 295                 300                 


Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala 
305                 310                 315                 320 


Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg 
                325                 330                 335     


Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys Thr 
            340                 345                 350         


Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His Glu 
        355                 360                 365             


Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro 
    370                 375                 380                 


Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu 
385                 390                 395                 400 


Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro 
                405                 410                 415     


Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly Lys 
            420                 425                 430         


Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys 
        435                 440                 445             


Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu His 
    450                 455                 460                 


Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser 
465                 470                 475                 480 


Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr 
                485                 490                 495     


Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala Asp 
            500                 505                 510         


Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala 
        515                 520                 525             


Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln Leu 
    530                 535                 540                 


Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys Lys 
545                 550                 555                 560 


Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu Val 
                565                 570                 575     


Ala Ala Ser Gln Ala Ala Leu Gly Leu Gly Ser Gly Gly Gly Gly Ser 
            580                 585                 590         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        595                 600                 605             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    610                 615                 620                 


Gly Gly Ser His Cys Pro Leu Gly Pro Gly Arg Cys Cys Arg Leu His 
625                 630                 635                 640 


Thr Val Arg Ala Ser Leu Glu Asp Leu Gly Trp Ala Asp Trp Val Leu 
                645                 650                 655     


Ser Pro Arg Glu Val Gln Val Thr Met Cys Ile Gly Ala Cys Pro Ser 
            660                 665                 670         


Gln Phe Arg Ala Ala Asn Met His Ala Gln Ile Lys Thr Ser Leu His 
        675                 680                 685             


Arg Leu Lys Pro Asp Thr Val Pro Ala Pro Cys Cys Val Pro Ala Ser 
    690                 695                 700                 


Tyr Asn Pro Met Val Leu Ile Gln Lys Thr Asp Thr Gly Val Ser Leu 
705                 710                 715                 720 


Gln Thr Tyr Asp Asp Leu Leu Ala Lys Asp Cys His Cys Ile 
                725                 730                 


<210>  112
<211>  725
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fusion protein

<400>  112

Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu 
1               5                   10                  15      


Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln 
            20                  25                  30          


Gln Ser Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr Glu 
        35                  40                  45              


Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys 
    50                  55                  60                  


Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu 
65                  70                  75                  80  


Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro 
                85                  90                  95      


Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu 
            100                 105                 110         


Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe His 
        115                 120                 125             


Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg 
    130                 135                 140                 


Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg 
145                 150                 155                 160 


Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala 
                165                 170                 175     


Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser 
            180                 185                 190         


Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu 
        195                 200                 205             


Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro 
    210                 215                 220                 


Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys 
225                 230                 235                 240 


Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp 
                245                 250                 255     


Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser 
            260                 265                 270         


Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His 
        275                 280                 285             


Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser 
    290                 295                 300                 


Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala 
305                 310                 315                 320 


Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg 
                325                 330                 335     


Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys Thr 
            340                 345                 350         


Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His Glu 
        355                 360                 365             


Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro 
    370                 375                 380                 


Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu 
385                 390                 395                 400 


Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro 
                405                 410                 415     


Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly Lys 
            420                 425                 430         


Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys 
        435                 440                 445             


Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu His 
    450                 455                 460                 


Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser 
465                 470                 475                 480 


Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr 
                485                 490                 495     


Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala Asp 
            500                 505                 510         


Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala 
        515                 520                 525             


Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln Leu 
    530                 535                 540                 


Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys Lys 
545                 550                 555                 560 


Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu Val 
                565                 570                 575     


Ala Ala Ser Gln Ala Ala Leu Gly Leu Gly Ser Gly Gly Gly Gly Ser 
            580                 585                 590         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        595                 600                 605             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    610                 615                 620                 


Gly Gly Ser Cys Arg Leu His Thr Val Arg Ala Ser Leu Glu Asp Leu 
625                 630                 635                 640 


Gly Trp Ala Asp Trp Val Leu Ser Pro Arg Glu Val Gln Val Thr Met 
                645                 650                 655     


Cys Ile Gly Ala Cys Pro Ser Gln Phe Arg Ala Ala Asn Met His Ala 
            660                 665                 670         


Gln Ile Lys Thr Ser Leu His Arg Leu Lys Pro Asp Thr Val Pro Ala 
        675                 680                 685             


Pro Cys Cys Val Pro Ala Ser Tyr Asn Pro Met Val Leu Ile Gln Lys 
    690                 695                 700                 


Thr Asp Thr Gly Val Ser Leu Gln Thr Tyr Asp Asp Leu Leu Ala Lys 
705                 710                 715                 720 


Asp Cys His Cys Ile 
                725 


<210>  113
<211>  733
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fusion protein

<400>  113

His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn 
1               5                   10                  15      


Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Ser 
            20                  25                  30          


Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala 
        35                  40                  45              


Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu 
    50                  55                  60                  


His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu 
65                  70                  75                  80  


Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg 
                85                  90                  95      


Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg 
            100                 105                 110         


Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn 
        115                 120                 125             


Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His 
    130                 135                 140                 


Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys 
145                 150                 155                 160 


Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu 
                165                 170                 175     


Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala 
            180                 185                 190         


Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala 
        195                 200                 205             


Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala 
    210                 215                 220                 


Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His 
225                 230                 235                 240 


Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala 
                245                 250                 255     


Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys 
            260                 265                 270         


Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile 
        275                 280                 285             


Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala 
    290                 295                 300                 


Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala 
305                 310                 315                 320 


Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His 
                325                 330                 335     


Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu 
            340                 345                 350         


Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr 
        355                 360                 365             


Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn 
    370                 375                 380                 


Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys 
385                 390                 395                 400 


Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val 
                405                 410                 415     


Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly 
            420                 425                 430         


Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu 
        435                 440                 445             


Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys 
    450                 455                 460                 


Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val 
465                 470                 475                 480 


Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val 
                485                 490                 495     


Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys 
            500                 505                 510         


Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val 
        515                 520                 525             


Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala 
    530                 535                 540                 


Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp 
545                 550                 555                 560 


Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala 
                565                 570                 575     


Ser Gln Ala Ala Leu Gly Leu Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            580                 585                 590         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        595                 600                 605             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    610                 615                 620                 


Ser Asp His Cys Pro Leu Gly Pro Gly Arg Cys Cys Arg Leu His Thr 
625                 630                 635                 640 


Val Arg Ala Ser Leu Glu Asp Leu Gly Trp Ala Asp Trp Val Leu Ser 
                645                 650                 655     


Pro Arg Glu Val Gln Val Thr Met Cys Ile Gly Ala Cys Pro Ser Gln 
            660                 665                 670         


Phe Arg Ala Ala Asn Met His Ala Gln Ile Lys Thr Ser Leu His Arg 
        675                 680                 685             


Leu Lys Pro Asp Thr Val Pro Ala Pro Cys Cys Val Pro Ala Ser Tyr 
    690                 695                 700                 


Asn Pro Met Val Leu Ile Gln Lys Thr Asp Thr Gly Val Ser Leu Gln 
705                 710                 715                 720 


Thr Tyr Asp Asp Leu Leu Ala Lys Asp Cys His Cys Ile 
                725                 730             


<210>  114
<211>  2199
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  fusion protein coding sequence

<400>  114
cacaagagtg aggttgctca tcggtttaaa gatttgggag aagaaaattt caaagccttg       60

gtgttgattg cctttgctca gtatcttcag cagtccccat ttgaagatca tgtaaaatta      120

gtgaatgaag taactgaatt tgcaaaaaca tgtgttgctg atgagtcagc tgaaaattgt      180

gacaaatcac ttcataccct ttttggagac aaattatgca cagttgcaac tcttcgtgaa      240

acctatggtg aaatggctga ctgctgtgca aaacaagaac ctgagagaaa tgaatgcttc      300

ttgcaacaca aagatgacaa cccaaacctc ccccgattgg tgagaccaga ggttgatgtg      360

atgtgcactg cttttcatga caatgaagag acatttttga aaaaatactt atatgaaatt      420

gccagaagac atccttactt ttatgccccg gaactccttt tctttgctaa aaggtataaa      480

gctgctttta cagaatgttg ccaagctgct gataaagctg cctgcctgtt gccaaagctc      540

gatgaacttc gggatgaagg gaaggcttcg tctgccaaac agagactcaa gtgtgccagt      600

ctccaaaaat ttggagaaag agctttcaaa gcatgggcag tagctcgcct gagccagaga      660

tttcccaaag ctgagtttgc agaagtttcc aagttagtga cagatcttac caaagtccac      720

acggaatgct gccatggaga tctgcttgaa tgtgctgatg acagggcgga ccttgccaag      780

tatatctgtg aaaatcaaga ttcgatctcc agtaaactga aggaatgctg tgaaaaacct      840

ctgttggaaa aatcccactg cattgccgaa gtggaaaatg atgagatgcc tgctgacttg      900

ccttcattag ctgctgattt tgttgaaagt aaggatgttt gcaaaaacta tgctgaggca      960

aaggatgtct tcctgggcat gtttttgtat gaatatgcaa gaaggcatcc tgattactct     1020

gtcgtgctgc tgctgagact tgccaagaca tatgaaacca ctctagagaa gtgctgtgcc     1080

gctgcagatc ctcatgaatg ctatgccaaa gtgttcgatg aatttaaacc tcttgtggaa     1140

gagcctcaga atttaatcaa acaaaattgt gagctttttg agcagcttgg agagtacaaa     1200

ttccagaatg cgctattagt tcgttacacc aagaaagtac cccaagtgtc aactccaact     1260

cttgtagagg tctcaagaaa cctaggaaaa gtgggcagca aatgttgtaa acatcctgaa     1320

gcaaaaagaa tgccctgtgc agaagactat ctatccgtgg tcctgaacca gttatgtgtg     1380

ttgcatgaga aaacgccagt aagtgacaga gtcaccaaat gctgcacaga atccttggtg     1440

aacaggcgac catgcttttc agctctggaa gtcgatgaaa catacgttcc caaagagttt     1500

aatgctgaaa cattcacctt ccatgcagat atatgcacac tttctgagaa ggagagacaa     1560

atcaagaaac aaactgcact tgttgagctc gtgaaacaca agcccaaggc aacaaaagag     1620

caactgaaag ctgttatgga tgatttcgca gcttttgtag agaagtgctg caaggctgac     1680

gataaggaga cctgctttgc cgaggagggt aaaaaacttg ttgctgcaag tcaagctgcc     1740

ttagggcttg gaagcggcgg aggggggagt ggcggcggtg gctccggggg gggcggatcc     1800

ggcggagggg gcagcggggg tggagggagt ggcgggggag gatcaggggg aggaggatca     1860

ggagggggcg gaagtgatca ttgccctctc gggcccggac ggtgttgccg cctccacact     1920

gtgagggctt cacttgaaga ccttggatgg gccgactggg tgctgtcccc aagagaggta     1980

caagtcacaa tgtgtattgg cgcctgcccc agccagtttc gcgccgctaa catgcacgcc     2040

cagataaaaa ccagcctgca ccgcctgaag cccgacacgg tgccagcgcc ctgctgcgtg     2100

cccgccagct acaatcccat ggtgctcatt caaaagaccg acaccggggt gtcgctccag     2160

acctatgatg acttgttagc caaagactgc cactgcata                            2199


<210>  115
<211>  735
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fusion protein

<400>  115

Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu 
1               5                   10                  15      


Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln 
            20                  25                  30          


Gln Ser Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr Glu 
        35                  40                  45              


Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys 
    50                  55                  60                  


Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu 
65                  70                  75                  80  


Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro 
                85                  90                  95      


Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu 
            100                 105                 110         


Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe His 
        115                 120                 125             


Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg 
    130                 135                 140                 


Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg 
145                 150                 155                 160 


Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala 
                165                 170                 175     


Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser 
            180                 185                 190         


Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu 
        195                 200                 205             


Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro 
    210                 215                 220                 


Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys 
225                 230                 235                 240 


Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp 
                245                 250                 255     


Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser 
            260                 265                 270         


Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His 
        275                 280                 285             


Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser 
    290                 295                 300                 


Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala 
305                 310                 315                 320 


Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg 
                325                 330                 335     


Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys Thr 
            340                 345                 350         


Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His Glu 
        355                 360                 365             


Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro 
    370                 375                 380                 


Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu 
385                 390                 395                 400 


Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro 
                405                 410                 415     


Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly Lys 
            420                 425                 430         


Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys 
        435                 440                 445             


Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu His 
    450                 455                 460                 


Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser 
465                 470                 475                 480 


Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr 
                485                 490                 495     


Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala Asp 
            500                 505                 510         


Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala 
        515                 520                 525             


Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln Leu 
    530                 535                 540                 


Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys Lys 
545                 550                 555                 560 


Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu Val 
                565                 570                 575     


Ala Ala Ser Gln Ala Ala Leu Gly Leu Gly Ala Gly Gly Gly Gly Ala 
            580                 585                 590         


Gly Gly Gly Gly Ala Gly Gly Gly Gly Ala Gly Gly Gly Gly Ala Gly 
        595                 600                 605             


Gly Gly Gly Ala Gly Gly Gly Gly Ala Gly Gly Gly Gly Ala Gly Gly 
    610                 615                 620                 


Gly Gly Ala Asp His Cys Pro Leu Gly Pro Gly Arg Cys Cys Arg Leu 
625                 630                 635                 640 


His Thr Val Arg Ala Ser Leu Glu Asp Leu Gly Trp Ala Asp Trp Val 
                645                 650                 655     


Leu Ser Pro Arg Glu Val Gln Val Thr Met Cys Ile Gly Ala Cys Pro 
            660                 665                 670         


Ser Gln Phe Arg Ala Ala Asn Met His Ala Gln Ile Lys Thr Ser Leu 
        675                 680                 685             


His Arg Leu Lys Pro Asp Thr Val Pro Ala Pro Cys Cys Val Pro Ala 
    690                 695                 700                 


Ser Tyr Asn Pro Met Val Leu Ile Gln Lys Thr Asp Thr Gly Val Ser 
705                 710                 715                 720 


Leu Gln Thr Tyr Asp Asp Leu Leu Ala Lys Asp Cys His Cys Ile 
                725                 730                 735 


<210>  116
<211>  2205
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  fusion protein coding sequence

<400>  116
gatgcacaca agagtgaggt tgctcatcgg tttaaagatt tgggagaaga aaatttcaaa       60

gccttggtgt tgattgcctt tgctcagtat cttcagcagt ccccatttga agatcatgta      120

aaattagtga atgaagtaac tgaatttgca aaaacatgtg ttgctgatga gtcagctgaa      180

aattgtgaca aatcacttca tacccttttt ggagacaaat tatgcacagt tgcaactctt      240

cgtgaaacct atggtgaaat ggctgactgc tgtgcaaaac aagaacctga gagaaatgaa      300

tgcttcttgc aacacaaaga tgacaaccca aacctccccc gattggtgag accagaggtt      360

gatgtgatgt gcactgcttt tcatgacaat gaagagacat ttttgaaaaa atacttatat      420

gaaattgcca gaagacatcc ttacttttat gccccggaac tccttttctt tgctaaaagg      480

tataaagctg cttttacaga atgttgccaa gctgctgata aagctgcctg cctgttgcca      540

aagctcgatg aacttcggga tgaagggaag gcttcgtctg ccaaacagag actcaagtgt      600

gccagtctcc aaaaatttgg agaaagagct ttcaaagcat gggcagtagc tcgcctgagc      660

cagagatttc ccaaagctga gtttgcagaa gtttccaagt tagtgacaga tcttaccaaa      720

gtccacacgg aatgctgcca tggagatctg cttgaatgtg ctgatgacag ggcggacctt      780

gccaagtata tctgtgaaaa tcaagattcg atctccagta aactgaagga atgctgtgaa      840

aaacctctgt tggaaaaatc ccactgcatt gccgaagtgg aaaatgatga gatgcctgct      900

gacttgcctt cattagctgc tgattttgtt gaaagtaagg atgtttgcaa aaactatgct      960

gaggcaaagg atgtcttcct gggcatgttt ttgtatgaat atgcaagaag gcatcctgat     1020

tactctgtcg tgctgctgct gagacttgcc aagacatatg aaaccactct agagaagtgc     1080

tgtgccgctg cagatcctca tgaatgctat gccaaagtgt tcgatgaatt taaacctctt     1140

gtggaagagc ctcagaattt aatcaaacaa aattgtgagc tttttgagca gcttggagag     1200

tacaaattcc agaatgcgct attagttcgt tacaccaaga aagtacccca agtgtcaact     1260

ccaactcttg tagaggtctc aagaaaccta ggaaaagtgg gcagcaaatg ttgtaaacat     1320

cctgaagcaa aaagaatgcc ctgtgcagaa gactatctat ccgtggtcct gaaccagtta     1380

tgtgtgttgc atgagaaaac gccagtaagt gacagagtca ccaaatgctg cacagaatcc     1440

ttggtgaaca ggcgaccatg cttttcagct ctggaagtcg atgaaacata cgttcccaaa     1500

gagtttaatg ctgaaacatt caccttccat gcagatatat gcacactttc tgagaaggag     1560

agacaaatca agaaacaaac tgcacttgtt gagctcgtga aacacaagcc caaggcaaca     1620

aaagagcaac tgaaagctgt tatggatgat ttcgcagctt ttgtagagaa gtgctgcaag     1680

gctgacgata aggagacctg ctttgccgag gagggtaaaa aacttgttgc tgcaagtcaa     1740

gctgccttag ggcttggtgc tggaggaggc ggggcgggcg gcgggggtgc cggtgggggt     1800

ggcgcagggg gaggtggtgc gggtggtggt ggggctggtg ggggaggtgc aggcggtggc     1860

ggtgccgggg ggggtggcgc ggatcattgc cctctcgggc ccggacggtg ttgccgcctc     1920

cacactgtga gggcttcact tgaagacctt ggatgggccg actgggtgct gtccccaaga     1980

gaggtacaag tcacaatgtg tattggcgcc tgccccagcc agtttcgcgc cgctaacatg     2040

cacgcccaga taaaaaccag cctgcaccgc ctgaagcccg acacggtgcc agcgccctgc     2100

tgcgtgcccg ccagctacaa tcccatggtg ctcattcaaa agaccgacac cggggtgtcg     2160

ctccagacct atgatgactt gttagccaaa gactgccact gcata                     2205


<210>  117
<211>  713
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fusion protein

<400>  117

Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu 
1               5                   10                  15      


Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln 
            20                  25                  30          


Gln Ser Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr Glu 
        35                  40                  45              


Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys 
    50                  55                  60                  


Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu 
65                  70                  75                  80  


Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro 
                85                  90                  95      


Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu 
            100                 105                 110         


Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe His 
        115                 120                 125             


Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg 
    130                 135                 140                 


Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg 
145                 150                 155                 160 


Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala 
                165                 170                 175     


Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser 
            180                 185                 190         


Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu 
        195                 200                 205             


Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro 
    210                 215                 220                 


Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys 
225                 230                 235                 240 


Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp 
                245                 250                 255     


Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser 
            260                 265                 270         


Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His 
        275                 280                 285             


Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser 
    290                 295                 300                 


Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala 
305                 310                 315                 320 


Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg 
                325                 330                 335     


Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys Thr 
            340                 345                 350         


Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His Glu 
        355                 360                 365             


Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro 
    370                 375                 380                 


Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu 
385                 390                 395                 400 


Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro 
                405                 410                 415     


Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly Lys 
            420                 425                 430         


Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys 
        435                 440                 445             


Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu His 
    450                 455                 460                 


Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser 
465                 470                 475                 480 


Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr 
                485                 490                 495     


Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala Asp 
            500                 505                 510         


Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala 
        515                 520                 525             


Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln Leu 
    530                 535                 540                 


Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys Lys 
545                 550                 555                 560 


Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu Val 
                565                 570                 575     


Ala Ala Ser Gln Ala Ala Leu Gly Leu Ala Pro Ala Pro Ala Pro Ala 
            580                 585                 590         


Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Asp His Cys 
        595                 600                 605             


Pro Leu Gly Pro Gly Arg Cys Cys Arg Leu His Thr Val Arg Ala Ser 
    610                 615                 620                 


Leu Glu Asp Leu Gly Trp Ala Asp Trp Val Leu Ser Pro Arg Glu Val 
625                 630                 635                 640 


Gln Val Thr Met Cys Ile Gly Ala Cys Pro Ser Gln Phe Arg Ala Ala 
                645                 650                 655     


Asn Met His Ala Gln Ile Lys Thr Ser Leu His Arg Leu Lys Pro Asp 
            660                 665                 670         


Thr Val Pro Ala Pro Cys Cys Val Pro Ala Ser Tyr Asn Pro Met Val 
        675                 680                 685             


Leu Ile Gln Lys Thr Asp Thr Gly Val Ser Leu Gln Thr Tyr Asp Asp 
    690                 695                 700                 


Leu Leu Ala Lys Asp Cys His Cys Ile 
705                 710             


<210>  118
<211>  2139
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  fusion protein coding sequence

<400>  118
gatgcacaca agagtgaggt tgctcatcgg tttaaagatt tgggagaaga aaatttcaaa       60

gccttggtgt tgattgcctt tgctcagtat cttcagcagt ccccatttga agatcatgta      120

aaattagtga atgaagtaac tgaatttgca aaaacatgtg ttgctgatga gtcagctgaa      180

aattgtgaca aatcacttca tacccttttt ggagacaaat tatgcacagt tgcaactctt      240

cgtgaaacct atggtgaaat ggctgactgc tgtgcaaaac aagaacctga gagaaatgaa      300

tgcttcttgc aacacaaaga tgacaaccca aacctccccc gattggtgag accagaggtt      360

gatgtgatgt gcactgcttt tcatgacaat gaagagacat ttttgaaaaa atacttatat      420

gaaattgcca gaagacatcc ttacttttat gccccggaac tccttttctt tgctaaaagg      480

tataaagctg cttttacaga atgttgccaa gctgctgata aagctgcctg cctgttgcca      540

aagctcgatg aacttcggga tgaagggaag gcttcgtctg ccaaacagag actcaagtgt      600

gccagtctcc aaaaatttgg agaaagagct ttcaaagcat gggcagtagc tcgcctgagc      660

cagagatttc ccaaagctga gtttgcagaa gtttccaagt tagtgacaga tcttaccaaa      720

gtccacacgg aatgctgcca tggagatctg cttgaatgtg ctgatgacag ggcggacctt      780

gccaagtata tctgtgaaaa tcaagattcg atctccagta aactgaagga atgctgtgaa      840

aaacctctgt tggaaaaatc ccactgcatt gccgaagtgg aaaatgatga gatgcctgct      900

gacttgcctt cattagctgc tgattttgtt gaaagtaagg atgtttgcaa aaactatgct      960

gaggcaaagg atgtcttcct gggcatgttt ttgtatgaat atgcaagaag gcatcctgat     1020

tactctgtcg tgctgctgct gagacttgcc aagacatatg aaaccactct agagaagtgc     1080

tgtgccgctg cagatcctca tgaatgctat gccaaagtgt tcgatgaatt taaacctctt     1140

gtggaagagc ctcagaattt aatcaaacaa aattgtgagc tttttgagca gcttggagag     1200

tacaaattcc agaatgcgct attagttcgt tacaccaaga aagtacccca agtgtcaact     1260

ccaactcttg tagaggtctc aagaaaccta ggaaaagtgg gcagcaaatg ttgtaaacat     1320

cctgaagcaa aaagaatgcc ctgtgcagaa gactatctat ccgtggtcct gaaccagtta     1380

tgtgtgttgc atgagaaaac gccagtaagt gacagagtca ccaaatgctg cacagaatcc     1440

ttggtgaaca ggcgaccatg cttttcagct ctggaagtcg atgaaacata cgttcccaaa     1500

gagtttaatg ctgaaacatt caccttccat gcagatatat gcacactttc tgagaaggag     1560

agacaaatca agaaacaaac tgcacttgtt gagctcgtga aacacaagcc caaggcaaca     1620

aaagagcaac tgaaagctgt tatggatgat ttcgcagctt ttgtagagaa gtgctgcaag     1680

gctgacgata aggagacctg ctttgccgag gagggtaaaa aacttgttgc tgcaagtcaa     1740

gctgccttag ggcttgcacc agcccctgcc cctgcacctg cacctgctcc cgcaccggct     1800

ccagccccag ctccggatca ttgccctctc gggcccggac ggtgttgccg cctccacact     1860

gtgagggctt cacttgaaga ccttggatgg gccgactggg tgctgtcccc aagagaggta     1920

caagtcacaa tgtgtattgg cgcctgcccc agccagtttc gcgccgctaa catgcacgcc     1980

cagataaaaa ccagcctgca ccgcctgaag cccgacacgg tgccagcgcc ctgctgcgtg     2040

cccgccagct acaatcccat ggtgctcatt caaaagaccg acaccggggt gtcgctccag     2100

acctatgatg acttgttagc caaagactgc cactgcata                            2139


<210>  119
<211>  717
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fusion protein

<400>  119

Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu 
1               5                   10                  15      


Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln 
            20                  25                  30          


Gln Ser Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr Glu 
        35                  40                  45              


Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys 
    50                  55                  60                  


Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu 
65                  70                  75                  80  


Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro 
                85                  90                  95      


Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu 
            100                 105                 110         


Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe His 
        115                 120                 125             


Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg 
    130                 135                 140                 


Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg 
145                 150                 155                 160 


Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala 
                165                 170                 175     


Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser 
            180                 185                 190         


Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu 
        195                 200                 205             


Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro 
    210                 215                 220                 


Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys 
225                 230                 235                 240 


Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp 
                245                 250                 255     


Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser 
            260                 265                 270         


Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His 
        275                 280                 285             


Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser 
    290                 295                 300                 


Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala 
305                 310                 315                 320 


Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg 
                325                 330                 335     


Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys Thr 
            340                 345                 350         


Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His Glu 
        355                 360                 365             


Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro 
    370                 375                 380                 


Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu 
385                 390                 395                 400 


Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro 
                405                 410                 415     


Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly Lys 
            420                 425                 430         


Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys 
        435                 440                 445             


Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu His 
    450                 455                 460                 


Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser 
465                 470                 475                 480 


Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr 
                485                 490                 495     


Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala Asp 
            500                 505                 510         


Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala 
        515                 520                 525             


Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln Leu 
    530                 535                 540                 


Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys Lys 
545                 550                 555                 560 


Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu Val 
                565                 570                 575     


Ala Ala Ser Gln Ala Ala Leu Gly Leu Ala Pro Ala Pro Ala Pro Ala 
            580                 585                 590         


Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala 
        595                 600                 605             


Pro Asp His Cys Pro Leu Gly Pro Gly Arg Cys Cys Arg Leu His Thr 
    610                 615                 620                 


Val Arg Ala Ser Leu Glu Asp Leu Gly Trp Ala Asp Trp Val Leu Ser 
625                 630                 635                 640 


Pro Arg Glu Val Gln Val Thr Met Cys Ile Gly Ala Cys Pro Ser Gln 
                645                 650                 655     


Phe Arg Ala Ala Asn Met His Ala Gln Ile Lys Thr Ser Leu His Arg 
            660                 665                 670         


Leu Lys Pro Asp Thr Val Pro Ala Pro Cys Cys Val Pro Ala Ser Tyr 
        675                 680                 685             


Asn Pro Met Val Leu Ile Gln Lys Thr Asp Thr Gly Val Ser Leu Gln 
    690                 695                 700                 


Thr Tyr Asp Asp Leu Leu Ala Lys Asp Cys His Cys Ile 
705                 710                 715         


<210>  120
<211>  2151
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  fusion protein coding sequence

<400>  120
gatgcacaca agagtgaggt tgctcatcgg tttaaagatt tgggagaaga aaatttcaaa       60

gccttggtgt tgattgcctt tgctcagtat cttcagcagt ccccatttga agatcatgta      120

aaattagtga atgaagtaac tgaatttgca aaaacatgtg ttgctgatga gtcagctgaa      180

aattgtgaca aatcacttca tacccttttt ggagacaaat tatgcacagt tgcaactctt      240

cgtgaaacct atggtgaaat ggctgactgc tgtgcaaaac aagaacctga gagaaatgaa      300

tgcttcttgc aacacaaaga tgacaaccca aacctccccc gattggtgag accagaggtt      360

gatgtgatgt gcactgcttt tcatgacaat gaagagacat ttttgaaaaa atacttatat      420

gaaattgcca gaagacatcc ttacttttat gccccggaac tccttttctt tgctaaaagg      480

tataaagctg cttttacaga atgttgccaa gctgctgata aagctgcctg cctgttgcca      540

aagctcgatg aacttcggga tgaagggaag gcttcgtctg ccaaacagag actcaagtgt      600

gccagtctcc aaaaatttgg agaaagagct ttcaaagcat gggcagtagc tcgcctgagc      660

cagagatttc ccaaagctga gtttgcagaa gtttccaagt tagtgacaga tcttaccaaa      720

gtccacacgg aatgctgcca tggagatctg cttgaatgtg ctgatgacag ggcggacctt      780

gccaagtata tctgtgaaaa tcaagattcg atctccagta aactgaagga atgctgtgaa      840

aaacctctgt tggaaaaatc ccactgcatt gccgaagtgg aaaatgatga gatgcctgct      900

gacttgcctt cattagctgc tgattttgtt gaaagtaagg atgtttgcaa aaactatgct      960

gaggcaaagg atgtcttcct gggcatgttt ttgtatgaat atgcaagaag gcatcctgat     1020

tactctgtcg tgctgctgct gagacttgcc aagacatatg aaaccactct agagaagtgc     1080

tgtgccgctg cagatcctca tgaatgctat gccaaagtgt tcgatgaatt taaacctctt     1140

gtggaagagc ctcagaattt aatcaaacaa aattgtgagc tttttgagca gcttggagag     1200

tacaaattcc agaatgcgct attagttcgt tacaccaaga aagtacccca agtgtcaact     1260

ccaactcttg tagaggtctc aagaaaccta ggaaaagtgg gcagcaaatg ttgtaaacat     1320

cctgaagcaa aaagaatgcc ctgtgcagaa gactatctat ccgtggtcct gaaccagtta     1380

tgtgtgttgc atgagaaaac gccagtaagt gacagagtca ccaaatgctg cacagaatcc     1440

ttggtgaaca ggcgaccatg cttttcagct ctggaagtcg atgaaacata cgttcccaaa     1500

gagtttaatg ctgaaacatt caccttccat gcagatatat gcacactttc tgagaaggag     1560

agacaaatca agaaacaaac tgcacttgtt gagctcgtga aacacaagcc caaggcaaca     1620

aaagagcaac tgaaagctgt tatggatgat ttcgcagctt ttgtagagaa gtgctgcaag     1680

gctgacgata aggagacctg ctttgccgag gagggtaaaa aacttgttgc tgcaagtcaa     1740

gctgccttag ggcttgcacc agcccctgcc cctgcacctg cacctgctcc cgcaccggct     1800

ccagccccag ctccggctcc agctcctgat cattgccctc tcgggcccgg acggtgttgc     1860

cgcctccaca ctgtgagggc ttcacttgaa gaccttggat gggccgactg ggtgctgtcc     1920

ccaagagagg tacaagtcac aatgtgtatt ggcgcctgcc ccagccagtt tcgcgccgct     1980

aacatgcacg cccagataaa aaccagcctg caccgcctga agcccgacac ggtgccagcg     2040

ccctgctgcg tgcccgccag ctacaatccc atggtgctca ttcaaaagac cgacaccggg     2100

gtgtcgctcc agacctatga tgacttgtta gccaaagact gccactgcat a              2151


<210>  121
<211>  741
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fusion protein

<400>  121

Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu 
1               5                   10                  15      


Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln 
            20                  25                  30          


Gln Ser Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr Glu 
        35                  40                  45              


Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys 
    50                  55                  60                  


Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu 
65                  70                  75                  80  


Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro 
                85                  90                  95      


Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu 
            100                 105                 110         


Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe His 
        115                 120                 125             


Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg 
    130                 135                 140                 


Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg 
145                 150                 155                 160 


Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala 
                165                 170                 175     


Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser 
            180                 185                 190         


Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu 
        195                 200                 205             


Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro 
    210                 215                 220                 


Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys 
225                 230                 235                 240 


Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp 
                245                 250                 255     


Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser 
            260                 265                 270         


Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His 
        275                 280                 285             


Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser 
    290                 295                 300                 


Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala 
305                 310                 315                 320 


Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg 
                325                 330                 335     


Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys Thr 
            340                 345                 350         


Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His Glu 
        355                 360                 365             


Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro 
    370                 375                 380                 


Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu 
385                 390                 395                 400 


Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro 
                405                 410                 415     


Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly Lys 
            420                 425                 430         


Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys 
        435                 440                 445             


Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu His 
    450                 455                 460                 


Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser 
465                 470                 475                 480 


Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr 
                485                 490                 495     


Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala Asp 
            500                 505                 510         


Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala 
        515                 520                 525             


Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln Leu 
    530                 535                 540                 


Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys Lys 
545                 550                 555                 560 


Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu Val 
                565                 570                 575     


Ala Ala Ser Gln Ala Ala Leu Gly Leu Gly Gly Ser Glu Gly Lys Ser 
            580                 585                 590         


Ser Gly Ser Gly Ser Glu Ser Lys Ser Thr Glu Gly Lys Ser Ser Gly 
        595                 600                 605             


Ser Gly Ser Glu Ser Lys Ser Thr Glu Gly Lys Ser Ser Gly Ser Gly 
    610                 615                 620                 


Ser Glu Ser Lys Ser Thr Gly Gly Ser Asp His Cys Pro Leu Gly Pro 
625                 630                 635                 640 


Gly Arg Cys Cys Arg Leu His Thr Val Arg Ala Ser Leu Glu Asp Leu 
                645                 650                 655     


Gly Trp Ala Asp Trp Val Leu Ser Pro Arg Glu Val Gln Val Thr Met 
            660                 665                 670         


Cys Ile Gly Ala Cys Pro Ser Gln Phe Arg Ala Ala Asn Met His Ala 
        675                 680                 685             


Gln Ile Lys Thr Ser Leu His Arg Leu Lys Pro Asp Thr Val Pro Ala 
    690                 695                 700                 


Pro Cys Cys Val Pro Ala Ser Tyr Asn Pro Met Val Leu Ile Gln Lys 
705                 710                 715                 720 


Thr Asp Thr Gly Val Ser Leu Gln Thr Tyr Asp Asp Leu Leu Ala Lys 
                725                 730                 735     


Asp Cys His Cys Ile 
            740     


<210>  122
<211>  2223
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  fusion protein coding sequence

<400>  122
gatgcacaca agagtgaggt tgctcatcgg tttaaagatt tgggagaaga aaatttcaaa       60

gccttggtgt tgattgcctt tgctcagtat cttcagcagt ccccatttga agatcatgta      120

aaattagtga atgaagtaac tgaatttgca aaaacatgtg ttgctgatga gtcagctgaa      180

aattgtgaca aatcacttca tacccttttt ggagacaaat tatgcacagt tgcaactctt      240

cgtgaaacct atggtgaaat ggctgactgc tgtgcaaaac aagaacctga gagaaatgaa      300

tgcttcttgc aacacaaaga tgacaaccca aacctccccc gattggtgag accagaggtt      360

gatgtgatgt gcactgcttt tcatgacaat gaagagacat ttttgaaaaa atacttatat      420

gaaattgcca gaagacatcc ttacttttat gccccggaac tccttttctt tgctaaaagg      480

tataaagctg cttttacaga atgttgccaa gctgctgata aagctgcctg cctgttgcca      540

aagctcgatg aacttcggga tgaagggaag gcttcgtctg ccaaacagag actcaagtgt      600

gccagtctcc aaaaatttgg agaaagagct ttcaaagcat gggcagtagc tcgcctgagc      660

cagagatttc ccaaagctga gtttgcagaa gtttccaagt tagtgacaga tcttaccaaa      720

gtccacacgg aatgctgcca tggagatctg cttgaatgtg ctgatgacag ggcggacctt      780

gccaagtata tctgtgaaaa tcaagattcg atctccagta aactgaagga atgctgtgaa      840

aaacctctgt tggaaaaatc ccactgcatt gccgaagtgg aaaatgatga gatgcctgct      900

gacttgcctt cattagctgc tgattttgtt gaaagtaagg atgtttgcaa aaactatgct      960

gaggcaaagg atgtcttcct gggcatgttt ttgtatgaat atgcaagaag gcatcctgat     1020

tactctgtcg tgctgctgct gagacttgcc aagacatatg aaaccactct agagaagtgc     1080

tgtgccgctg cagatcctca tgaatgctat gccaaagtgt tcgatgaatt taaacctctt     1140

gtggaagagc ctcagaattt aatcaaacaa aattgtgagc tttttgagca gcttggagag     1200

tacaaattcc agaatgcgct attagttcgt tacaccaaga aagtacccca agtgtcaact     1260

ccaactcttg tagaggtctc aagaaaccta ggaaaagtgg gcagcaaatg ttgtaaacat     1320

cctgaagcaa aaagaatgcc ctgtgcagaa gactatctat ccgtggtcct gaaccagtta     1380

tgtgtgttgc atgagaaaac gccagtaagt gacagagtca caaaatgctg tactgagagc     1440

ttggtcaaca ggcggccgtg cttcagcgcc ctcgaggtgg atgagactta tgtcccaaag     1500

gagtttaatg cggaaacttt tactttccac gcagacattt gcaccttgtc tgaaaaggaa     1560

agacagatta agaaacagac tgctcttgtg gaactggtaa aacataaacc aaaagctacg     1620

aaggagcagc ttaaggctgt tatggatgat ttcgccgcgt ttgtcgagaa gtgctgcaaa     1680

gcggacgata aggaaacttg ctttgcagag gaaggtaaga aactcgtagc ggcaagtcag     1740

gctgcgcttg gccttggagg cagtgaaggc aaatcctctg ggagtggctc tgaaagtaaa     1800

tccaccgagg gcaaatccag tggatctggg tctgaatcta agtctaccga ggggaagtct     1860

tctggcagtg ggtcagaatc taaatctaca ggcggctctg accattgccc gttgggacca     1920

ggacgctgct gtcgccttca tacagtgcga gcgagtttgg aagacctggg ctgggctgac     1980

tgggtgctta gccctcggga ggtccaggtc acaatgtgca ttggcgcgtg tcccagtcaa     2040

tttagagcag caaatatgca cgcccaaata aaaacctccc tgcataggct taagccagat     2100

actgtccccg caccatgctg tgtgcctgct tcttacaatc ctatggtact catccagaag     2160

accgacacgg gagttagcct ccagacttat gacgacctct tggctaaaga ttgccattgt     2220

att                                                                   2223


<210>  123
<211>  735
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fusion protein

<400>  123

Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu 
1               5                   10                  15      


Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln 
            20                  25                  30          


Gln Ser Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr Glu 
        35                  40                  45              


Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys 
    50                  55                  60                  


Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu 
65                  70                  75                  80  


Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro 
                85                  90                  95      


Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu 
            100                 105                 110         


Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe His 
        115                 120                 125             


Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg 
    130                 135                 140                 


Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg 
145                 150                 155                 160 


Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala 
                165                 170                 175     


Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser 
            180                 185                 190         


Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu 
        195                 200                 205             


Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro 
    210                 215                 220                 


Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys 
225                 230                 235                 240 


Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp 
                245                 250                 255     


Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser 
            260                 265                 270         


Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His 
        275                 280                 285             


Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser 
    290                 295                 300                 


Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala 
305                 310                 315                 320 


Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg 
                325                 330                 335     


Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys Thr 
            340                 345                 350         


Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His Glu 
        355                 360                 365             


Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro 
    370                 375                 380                 


Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu 
385                 390                 395                 400 


Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro 
                405                 410                 415     


Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly Lys 
            420                 425                 430         


Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys 
        435                 440                 445             


Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu His 
    450                 455                 460                 


Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser 
465                 470                 475                 480 


Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr 
                485                 490                 495     


Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala Asp 
            500                 505                 510         


Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala 
        515                 520                 525             


Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln Leu 
    530                 535                 540                 


Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys Lys 
545                 550                 555                 560 


Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu Val 
                565                 570                 575     


Ala Ala Ser Gln Ala Ala Leu Gly Leu Gly Ser Pro Gly Gly Gly Ser 
            580                 585                 590         


Pro Gly Gly Gly Ser Pro Gly Gly Gly Ser Pro Gly Gly Gly Ser Pro 
        595                 600                 605             


Gly Gly Gly Ser Pro Gly Gly Gly Ser Pro Gly Gly Gly Ser Pro Gly 
    610                 615                 620                 


Gly Gly Ser Asp His Cys Pro Leu Gly Pro Gly Arg Cys Cys Arg Leu 
625                 630                 635                 640 


His Thr Val Arg Ala Ser Leu Glu Asp Leu Gly Trp Ala Asp Trp Val 
                645                 650                 655     


Leu Ser Pro Arg Glu Val Gln Val Thr Met Cys Ile Gly Ala Cys Pro 
            660                 665                 670         


Ser Gln Phe Arg Ala Ala Asn Met His Ala Gln Ile Lys Thr Ser Leu 
        675                 680                 685             


His Arg Leu Lys Pro Asp Thr Val Pro Ala Pro Cys Cys Val Pro Ala 
    690                 695                 700                 


Ser Tyr Asn Pro Met Val Leu Ile Gln Lys Thr Asp Thr Gly Val Ser 
705                 710                 715                 720 


Leu Gln Thr Tyr Asp Asp Leu Leu Ala Lys Asp Cys His Cys Ile 
                725                 730                 735 


<210>  124
<211>  2205
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  fusion protein coding sequence

<400>  124
gatgcacaca agagtgaggt tgctcatcgg tttaaagatt tgggagaaga aaatttcaaa       60

gccttggtgt tgattgcctt tgctcagtat cttcagcagt ccccatttga agatcatgta      120

aaattagtga atgaagtaac tgaatttgca aaaacatgtg ttgctgatga gtcagctgaa      180

aattgtgaca aatcacttca tacccttttt ggagacaaat tatgcacagt tgcaactctt      240

cgtgaaacct atggtgaaat ggctgactgc tgtgcaaaac aagaacctga gagaaatgaa      300

tgcttcttgc aacacaaaga tgacaaccca aacctccccc gattggtgag accagaggtt      360

gatgtgatgt gcactgcttt tcatgacaat gaagagacat ttttgaaaaa atacttatat      420

gaaattgcca gaagacatcc ttacttttat gccccggaac tccttttctt tgctaaaagg      480

tataaagctg cttttacaga atgttgccaa gctgctgata aagctgcctg cctgttgcca      540

aagctcgatg aacttcggga tgaagggaag gcttcgtctg ccaaacagag actcaagtgt      600

gccagtctcc aaaaatttgg agaaagagct ttcaaagcat gggcagtagc tcgcctgagc      660

cagagatttc ccaaagctga gtttgcagaa gtttccaagt tagtgacaga tcttaccaaa      720

gtccacacgg aatgctgcca tggagatctg cttgaatgtg ctgatgacag ggcggacctt      780

gccaagtata tctgtgaaaa tcaagattcg atctccagta aactgaagga atgctgtgaa      840

aaacctctgt tggaaaaatc ccactgcatt gccgaagtgg aaaatgatga gatgcctgct      900

gacttgcctt cattagctgc tgattttgtt gaaagtaagg atgtttgcaa aaactatgct      960

gaggcaaagg atgtcttcct gggcatgttt ttgtatgaat atgcaagaag gcatcctgat     1020

tactctgtcg tgctgctgct gagacttgcc aagacatatg aaaccactct agagaagtgc     1080

tgtgccgctg cagatcctca tgaatgctat gccaaagtgt tcgatgaatt taaacctctt     1140

gtggaagagc ctcagaattt aatcaaacaa aattgtgagc tttttgagca gcttggagag     1200

tacaaattcc agaatgcgct attagttcgt tacaccaaga aagtacccca agtgtcaact     1260

ccaactcttg tagaggtctc aagaaaccta ggaaaagtgg gcagcaaatg ttgtaaacat     1320

cctgaagcaa aaagaatgcc ctgtgcagaa gactatctat ccgtggtcct gaaccagtta     1380

tgtgtgttgc atgagaaaac gccagtaagt gacagagtca cgaaatgttg cacagagtca     1440

ctggtcaaca ggagaccttg cttctccgct cttgaggttg acgaaacgta tgtcccaaaa     1500

gagttcaacg ccgaaacgtt tacgtttcat gcggacatat gcactctcag tgagaaggag     1560

cgacaaatca aaaaacagac tgctcttgta gagttggtaa aacacaaacc taaagcaaca     1620

aaagagcaat tgaaagctgt gatggacgat tttgcagctt tcgtagaaaa gtgctgcaag     1680

gccgacgata aagaaacctg tttcgctgaa gaaggcaaaa aacttgttgc ggcatctcag     1740

gccgctcttg gacttgggag cccgggtggc gggtctccag gcggaggctc tccgggcgga     1800

ggtagtcccg gagggggtag tccgggcggc ggttctccag gtggaggttc tcctggtggt     1860

ggcagtcctg gcggaggatc tgatcactgt ccccttgggc ccgggaggtg ctgccgactt     1920

catacagttc gcgccagcct tgaagatttg gggtgggccg actgggtgtt gagcccgaga     1980

gaggtccaag tcacgatgtg tattggagcc tgtccctctc aattccgagc cgcaaatatg     2040

catgcgcaaa taaagacgag tctccatcgg ttgaagcctg atactgtccc agctccgtgc     2100

tgcgtccccg cgagttataa tcccatggtc cttatacaga aaacagacac tggtgtcagc     2160

cttcagacgt atgacgattt gcttgctaaa gactgtcatt gtatt                     2205


<210>  125
<211>  735
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fusion protein

<400>  125

Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu 
1               5                   10                  15      


Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln 
            20                  25                  30          


Gln Ser Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr Glu 
        35                  40                  45              


Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys 
    50                  55                  60                  


Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu 
65                  70                  75                  80  


Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro 
                85                  90                  95      


Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu 
            100                 105                 110         


Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe His 
        115                 120                 125             


Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg 
    130                 135                 140                 


Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg 
145                 150                 155                 160 


Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala 
                165                 170                 175     


Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser 
            180                 185                 190         


Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu 
        195                 200                 205             


Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro 
    210                 215                 220                 


Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys 
225                 230                 235                 240 


Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp 
                245                 250                 255     


Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser 
            260                 265                 270         


Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His 
        275                 280                 285             


Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser 
    290                 295                 300                 


Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala 
305                 310                 315                 320 


Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg 
                325                 330                 335     


Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys Thr 
            340                 345                 350         


Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His Glu 
        355                 360                 365             


Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro 
    370                 375                 380                 


Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu 
385                 390                 395                 400 


Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro 
                405                 410                 415     


Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly Lys 
            420                 425                 430         


Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys 
        435                 440                 445             


Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu His 
    450                 455                 460                 


Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser 
465                 470                 475                 480 


Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr 
                485                 490                 495     


Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala Asp 
            500                 505                 510         


Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala 
        515                 520                 525             


Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln Leu 
    530                 535                 540                 


Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys Lys 
545                 550                 555                 560 


Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu Val 
                565                 570                 575     


Ala Ala Ser Gln Ala Ala Leu Gly Leu Gly Ser Ala Gly Gly Gly Ser 
            580                 585                 590         


Ala Gly Gly Gly Ser Ala Gly Gly Gly Ser Ala Gly Gly Gly Ser Ala 
        595                 600                 605             


Gly Gly Gly Ser Ala Gly Gly Gly Ser Ala Gly Gly Gly Ser Ala Gly 
    610                 615                 620                 


Gly Gly Ser Asp His Cys Pro Leu Gly Pro Gly Arg Cys Cys Arg Leu 
625                 630                 635                 640 


His Thr Val Arg Ala Ser Leu Glu Asp Leu Gly Trp Ala Asp Trp Val 
                645                 650                 655     


Leu Ser Pro Arg Glu Val Gln Val Thr Met Cys Ile Gly Ala Cys Pro 
            660                 665                 670         


Ser Gln Phe Arg Ala Ala Asn Met His Ala Gln Ile Lys Thr Ser Leu 
        675                 680                 685             


His Arg Leu Lys Pro Asp Thr Val Pro Ala Pro Cys Cys Val Pro Ala 
    690                 695                 700                 


Ser Tyr Asn Pro Met Val Leu Ile Gln Lys Thr Asp Thr Gly Val Ser 
705                 710                 715                 720 


Leu Gln Thr Tyr Asp Asp Leu Leu Ala Lys Asp Cys His Cys Ile 
                725                 730                 735 


<210>  126
<211>  2205
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  fusion protein coding sequence

<400>  126
gatgcacaca agagtgaggt tgctcatcgg tttaaagatt tgggagaaga aaatttcaaa       60

gccttggtgt tgattgcctt tgctcagtat cttcagcagt ccccatttga agatcatgta      120

aaattagtga atgaagtaac tgaatttgca aaaacatgtg ttgctgatga gtcagctgaa      180

aattgtgaca aatcacttca tacccttttt ggagacaaat tatgcacagt tgcaactctt      240

cgtgaaacct atggtgaaat ggctgactgc tgtgcaaaac aagaacctga gagaaatgaa      300

tgcttcttgc aacacaaaga tgacaaccca aacctccccc gattggtgag accagaggtt      360

gatgtgatgt gcactgcttt tcatgacaat gaagagacat ttttgaaaaa atacttatat      420

gaaattgcca gaagacatcc ttacttttat gccccggaac tccttttctt tgctaaaagg      480

tataaagctg cttttacaga atgttgccaa gctgctgata aagctgcctg cctgttgcca      540

aagctcgatg aacttcggga tgaagggaag gcttcgtctg ccaaacagag actcaagtgt      600

gccagtctcc aaaaatttgg agaaagagct ttcaaagcat gggcagtagc tcgcctgagc      660

cagagatttc ccaaagctga gtttgcagaa gtttccaagt tagtgacaga tcttaccaaa      720

gtccacacgg aatgctgcca tggagatctg cttgaatgtg ctgatgacag ggcggacctt      780

gccaagtata tctgtgaaaa tcaagattcg atctccagta aactgaagga atgctgtgaa      840

aaacctctgt tggaaaaatc ccactgcatt gccgaagtgg aaaatgatga gatgcctgct      900

gacttgcctt cattagctgc tgattttgtt gaaagtaagg atgtttgcaa aaactatgct      960

gaggcaaagg atgtcttcct gggcatgttt ttgtatgaat atgcaagaag gcatcctgat     1020

tactctgtcg tgctgctgct gagacttgcc aagacatatg aaaccactct agagaagtgc     1080

tgtgccgctg cagatcctca tgaatgctat gccaaagtgt tcgatgaatt taaacctctt     1140

gtggaagagc ctcagaattt aatcaaacaa aattgtgagc tttttgagca gcttggagag     1200

tacaaattcc agaatgcgct attagttcgt tacaccaaga aagtacccca agtgtcaact     1260

ccaactcttg tagaggtctc aagaaaccta ggaaaagtgg gcagcaaatg ttgtaaacat     1320

cctgaagcaa aaagaatgcc ctgtgcagaa gactatctat ccgtggtcct gaaccagtta     1380

tgtgtgttgc atgagaaaac gccagtaagt gacagagtca ctaaatgttg taccgagtct     1440

cttgttaata ggcggccatg cttcagtgca ttggaagtcg acgaaaccta tgtaccaaag     1500

gagttcaacg cagaaacatt tacattccat gctgatatct gcacattgag cgagaaagag     1560

agacagatta agaaacagac agcgcttgtt gaactggtta aacacaaacc aaaagctacc     1620

aaggagcagc ttaaggcagt aatggatgac ttcgcggcct ttgtcgagaa atgttgtaaa     1680

gcggatgata aagagacatg cttcgccgaa gagggcaaaa aacttgtagc ggcaagccag     1740

gccgcactgg gtctcggtag tgcgggcggt ggttcagcgg ggggaggatc tgcaggtggt     1800

ggctcagcgg gtggcggtag cgctgggggg ggctccgcag gtgggggatc agcaggcggc     1860

ggatcagccg gcggtggatc cgaccactgt cctctcgggc ctggtcggtg ttgccgcctc     1920

catactgtgc gcgcgtctct tgaggatctg gggtgggctg attgggttct ctctccccgc     1980

gaagtgcagg tgaccatgtg tattggtgct tgcccaagtc aattccgagc agctaacatg     2040

cacgcccaga tcaagactag cctgcatcgg cttaagcccg acactgttcc tgccccttgc     2100

tgtgttcctg catcttataa tccaatggtc ctgatccaga aaaccgatac gggtgtatca     2160

ttgcaaacat acgacgactt gcttgccaaa gattgccatt gcatt                     2205


<210>  127
<211>  727
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fusion protein

<400>  127

Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu 
1               5                   10                  15      


Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln 
            20                  25                  30          


Gln Ser Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr Glu 
        35                  40                  45              


Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys 
    50                  55                  60                  


Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu 
65                  70                  75                  80  


Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro 
                85                  90                  95      


Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu 
            100                 105                 110         


Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe His 
        115                 120                 125             


Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg 
    130                 135                 140                 


Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg 
145                 150                 155                 160 


Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala 
                165                 170                 175     


Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser 
            180                 185                 190         


Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu 
        195                 200                 205             


Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro 
    210                 215                 220                 


Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys 
225                 230                 235                 240 


Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp 
                245                 250                 255     


Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser 
            260                 265                 270         


Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His 
        275                 280                 285             


Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser 
    290                 295                 300                 


Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala 
305                 310                 315                 320 


Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg 
                325                 330                 335     


Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys Thr 
            340                 345                 350         


Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His Glu 
        355                 360                 365             


Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro 
    370                 375                 380                 


Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu 
385                 390                 395                 400 


Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro 
                405                 410                 415     


Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly Lys 
            420                 425                 430         


Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys 
        435                 440                 445             


Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu His 
    450                 455                 460                 


Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser 
465                 470                 475                 480 


Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr 
                485                 490                 495     


Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala Asp 
            500                 505                 510         


Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala 
        515                 520                 525             


Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln Leu 
    530                 535                 540                 


Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys Lys 
545                 550                 555                 560 


Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu Val 
                565                 570                 575     


Ala Ala Ser Gln Ala Ala Leu Gly Leu Gly Gly Ser Glu Gly Lys Ser 
            580                 585                 590         


Ser Gly Ser Gly Ser Glu Ser Lys Ser Thr Glu Gly Lys Ser Ser Gly 
        595                 600                 605             


Ser Gly Ser Glu Ser Lys Ser Thr Gly Gly Ser Asp His Cys Pro Leu 
    610                 615                 620                 


Gly Pro Gly Arg Cys Cys Arg Leu His Thr Val Arg Ala Ser Leu Glu 
625                 630                 635                 640 


Asp Leu Gly Trp Ala Asp Trp Val Leu Ser Pro Arg Glu Val Gln Val 
                645                 650                 655     


Thr Met Cys Ile Gly Ala Cys Pro Ser Gln Phe Arg Ala Ala Asn Met 
            660                 665                 670         


His Ala Gln Ile Lys Thr Ser Leu His Arg Leu Lys Pro Asp Thr Val 
        675                 680                 685             


Pro Ala Pro Cys Cys Val Pro Ala Ser Tyr Asn Pro Met Val Leu Ile 
    690                 695                 700                 


Gln Lys Thr Asp Thr Gly Val Ser Leu Gln Thr Tyr Asp Asp Leu Leu 
705                 710                 715                 720 


Ala Lys Asp Cys His Cys Ile 
                725         


<210>  128
<211>  2181
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  fusion protein coding sequence

<400>  128

gatgcacaca agagtgaggt tgctcatcgg tttaaagatt tgggagaaga aaatttcaaa       60

gccttggtgt tgattgcctt tgctcagtat cttcagcagt ccccatttga agatcatgta      120

aaattagtga atgaagtaac tgaatttgca aaaacatgtg ttgctgatga gtcagctgaa      180

aattgtgaca aatcacttca tacccttttt ggagacaaat tatgcacagt tgcaactctt      240

cgtgaaacct atggtgaaat ggctgactgc tgtgcaaaac aagaacctga gagaaatgaa      300

tgcttcttgc aacacaaaga tgacaaccca aacctccccc gattggtgag accagaggtt      360

gatgtgatgt gcactgcttt tcatgacaat gaagagacat ttttgaaaaa atacttatat      420

gaaattgcca gaagacatcc ttacttttat gccccggaac tccttttctt tgctaaaagg      480

tataaagctg cttttacaga atgttgccaa gctgctgata aagctgcctg cctgttgcca      540

aagctcgatg aacttcggga tgaagggaag gcttcgtctg ccaaacagag actcaagtgt      600

gccagtctcc aaaaatttgg agaaagagct ttcaaagcat gggcagtagc tcgcctgagc      660

cagagatttc ccaaagctga gtttgcagaa gtttccaagt tagtgacaga tcttaccaaa      720

gtccacacgg aatgctgcca tggagatctg cttgaatgtg ctgatgacag ggcggacctt      780

gccaagtata tctgtgaaaa tcaagattcg atctccagta aactgaagga atgctgtgaa      840

aaacctctgt tggaaaaatc ccactgcatt gccgaagtgg aaaatgatga gatgcctgct      900

gacttgcctt cattagctgc tgattttgtt gaaagtaagg atgtttgcaa aaactatgct      960

gaggcaaagg atgtcttcct gggcatgttt ttgtatgaat atgcaagaag gcatcctgat     1020

tactctgtcg tgctgctgct gagacttgcc aagacatatg aaaccactct agagaagtgc     1080

tgtgccgctg cagatcctca tgaatgctat gccaaagtgt tcgatgaatt taaacctctt     1140

gtggaagagc ctcagaattt aatcaaacaa aattgtgagc tttttgagca gcttggagag     1200

tacaaattcc agaatgcgct attagttcgt tacaccaaga aagtacccca agtgtcaact     1260

ccaactcttg tagaggtctc aagaaaccta ggaaaagtgg gcagcaaatg ttgtaaacat     1320

cctgaagcaa aaagaatgcc ctgtgcagaa gactatctat ccgtggtcct gaaccagtta     1380

tgtgtgttgc atgagaaaac gccagtaagt gacagagtca cgaaatgctg tacagaatcc     1440

ctcgtgaata gaaggccctg cttctctgcc cttgaggtgg acgagactta cgtccctaag     1500

gagtttaacg ccgagacctt tacttttcat gctgatattt gcaccctttc cgaaaaggag     1560

cggcagatca agaaacaaac agccttggtg gaactcgtaa aacataaacc caaagccacc     1620

aaggaacaac ttaaagctgt tatggatgac ttcgcagcct tcgtcgagaa atgttgcaag     1680

gcggatgata aggaaacgtg ttttgctgag gaagggaaga agttggttgc tgcctctcaa     1740

gcggctctgg ggcttggcgg atcagagggg aagtcctccg ggtccggtag cgagtccaaa     1800

tctacggaag ggaagtcatc cggttctggg tcagagtcca aatccacagg aggatcagac     1860

cattgcccat tgggaccagg acgatgttgt cgcctgcata cggtaagagc gtctctggag     1920

gatctcggct gggccgattg ggttctctca ccacgagaag tacaggtcac aatgtgcata     1980

ggagcttgtc cgagccaatt ccgggcggct aatatgcacg cacagatcaa gacctctttg     2040

caccgcttga agcccgatac cgtgccagca ccgtgttgcg tcccagcatc ttacaaccct     2100

atggttttga tacagaaaac tgacacaggt gtgagcctcc agacatatga tgatttgctg     2160

gctaaggatt gccactgtat a                                               2181


