                         LISTADO DE SECUENCIAS

<110>  Consejo Superior de Investigaciones Cientficas (CSIC)
       Universidad Autnoma de Madrid (UAM)	
 
<120>  Mtodo de doble hbrido en reverso para la identificacin de 
       mutaciones missense

<130>  1641.1111

<150>  P201630607
<151>  2016-05-11

<160>  53    

<170>  PatentIn version 3.5

<210>  1
<211>  1878
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(1878)

<400>  1
atg cca ggc aca aaa cgg ttt caa cat gtc att gag acc ccg gag cct         48
Met Pro Gly Thr Lys Arg Phe Gln His Val Ile Glu Thr Pro Glu Pro           
1               5                   10                  15                

ggc aag tgg gag ttg tct ggg tac gag gca gct gtg cca atc acg gag         96
Gly Lys Trp Glu Leu Ser Gly Tyr Glu Ala Ala Val Pro Ile Thr Glu           
            20                  25                  30                    

aag tca aac cca ctg acc cag gat cta gac aaa gca gat gct gag aac        144
Lys Ser Asn Pro Leu Thr Gln Asp Leu Asp Lys Ala Asp Ala Glu Asn           
        35                  40                  45                        

att gtt cga ctg cta ggg caa tgt gat gct gag atc ttc cag gag gag        192
Ile Val Arg Leu Leu Gly Gln Cys Asp Ala Glu Ile Phe Gln Glu Glu           
    50                  55                  60                            

ggg caa gcc ctg tcc aca tac cag aga ctc tac agc gaa tcc att ctg        240
Gly Gln Ala Leu Ser Thr Tyr Gln Arg Leu Tyr Ser Glu Ser Ile Leu           
65                  70                  75                  80            

acc acc atg gta cag gtg gct ggg aaa gtt cag gaa gtg ctg aag gag        288
Thr Thr Met Val Gln Val Ala Gly Lys Val Gln Glu Val Leu Lys Glu           
                85                  90                  95                

cca gat ggg ggg ctg gtt gtg ctg agt gga ggg ggc acc tct ggc cgg        336
Pro Asp Gly Gly Leu Val Val Leu Ser Gly Gly Gly Thr Ser Gly Arg           
            100                 105                 110                   

atg gca ttc ctc atg tcg gtg tcc ttt aat cag ctg atg aaa ggt ctg        384
Met Ala Phe Leu Met Ser Val Ser Phe Asn Gln Leu Met Lys Gly Leu           
        115                 120                 125                       

gga cag aaa cct ctt tac acc tac ctc att gca ggt ggt gac agg tct        432
Gly Gln Lys Pro Leu Tyr Thr Tyr Leu Ile Ala Gly Gly Asp Arg Ser           
    130                 135                 140                           

gtg gtg gcc tct agg gag ggg aca gaa gat agt gcc ttg cac ggg att        480
Val Val Ala Ser Arg Glu Gly Thr Glu Asp Ser Ala Leu His Gly Ile           
145                 150                 155                 160           

gag gaa ctg aag aag gtg gct gcc ggg aag aag aga gtg att gtc att        528
Glu Glu Leu Lys Lys Val Ala Ala Gly Lys Lys Arg Val Ile Val Ile           
                165                 170                 175               

ggc att tct gtg gga ctc tct gct ccc ttt gtg gca ggc cag atg gac        576
Gly Ile Ser Val Gly Leu Ser Ala Pro Phe Val Ala Gly Gln Met Asp           
            180                 185                 190                   

tgc tgc atg aac aac aca gct gtc ttc ttg cca gtc ctg gtt ggc ttc        624
Cys Cys Met Asn Asn Thr Ala Val Phe Leu Pro Val Leu Val Gly Phe           
        195                 200                 205                       

aat cca gtg agc atg gcc aga aat gac ccc att gaa gac tgg agt tca        672
Asn Pro Val Ser Met Ala Arg Asn Asp Pro Ile Glu Asp Trp Ser Ser           
    210                 215                 220                           

aca ttc cga caa gta gca gag cgg atg cag aaa atg cag gag aaa cag        720
Thr Phe Arg Gln Val Ala Glu Arg Met Gln Lys Met Gln Glu Lys Gln           
225                 230                 235                 240           

aaa gct ttt gtg ctc aat cct gcc atc ggg ccc gag ggt ctc agc ggc        768
Lys Ala Phe Val Leu Asn Pro Ala Ile Gly Pro Glu Gly Leu Ser Gly           
                245                 250                 255               

tcc tcc cgg atg aaa ggt gga agt gcc acc aag att ctg ctg gaa acc        816
Ser Ser Arg Met Lys Gly Gly Ser Ala Thr Lys Ile Leu Leu Glu Thr           
            260                 265                 270                   

ctg tta tta gca gcc cat aag act gtg gac cag ggc att gca gca tct        864
Leu Leu Leu Ala Ala His Lys Thr Val Asp Gln Gly Ile Ala Ala Ser           
        275                 280                 285                       

caa aga tgc ctc ctg gaa atc ttg cgg aca ttt gag cga gct cat cag        912
Gln Arg Cys Leu Leu Glu Ile Leu Arg Thr Phe Glu Arg Ala His Gln           
    290                 295                 300                           

gtg acc tac agc caa agc ccc aag att gcc acc ctg atg aag agt gtc        960
Val Thr Tyr Ser Gln Ser Pro Lys Ile Ala Thr Leu Met Lys Ser Val           
305                 310                 315                 320           

agc acc agt ctg gag aag aaa ggc cac gtg tac ctg gtt ggc tgg cag       1008
Ser Thr Ser Leu Glu Lys Lys Gly His Val Tyr Leu Val Gly Trp Gln           
                325                 330                 335               

acc ctg ggt atc att gcc atc atg gat gga gta gag tgc atc cac acc       1056
Thr Leu Gly Ile Ile Ala Ile Met Asp Gly Val Glu Cys Ile His Thr           
            340                 345                 350                   

ttt ggt gct gat ttc cga gat gtc cgt ggc ttt ctc att ggt gat cac       1104
Phe Gly Ala Asp Phe Arg Asp Val Arg Gly Phe Leu Ile Gly Asp His           
        355                 360                 365                       

agt gac atg ttt aac cag aag gct gag ctc acc aac cag ggt ccc cag       1152
Ser Asp Met Phe Asn Gln Lys Ala Glu Leu Thr Asn Gln Gly Pro Gln           
    370                 375                 380                           

ttc acc ttc tcc cag gag gac ttc ccg act tcc atc ctt ccc tct ctc       1200
Phe Thr Phe Ser Gln Glu Asp Phe Pro Thr Ser Ile Leu Pro Ser Leu           
385                 390                 395                 400           

acg gaa atc gat act gtg gtc ttc att ttc acc ctg gat gac aac ctc       1248
Thr Glu Ile Asp Thr Val Val Phe Ile Phe Thr Leu Asp Asp Asn Leu           
                405                 410                 415               

acg gag gtg cag act ata gtg gag cag gtg aaa gag aag acc aac cac       1296
Thr Glu Val Gln Thr Ile Val Glu Gln Val Lys Glu Lys Thr Asn His           
            420                 425                 430                   

atc cag gcc ctg gca cac agc acc gtg ggt cag acc ttg ccg atc cct       1344
Ile Gln Ala Leu Ala His Ser Thr Val Gly Gln Thr Leu Pro Ile Pro           
        435                 440                 445                       

ctg aag aag ctc ttt ccc tcc atc atc agc atc aca tgg cca ctg ctt       1392
Leu Lys Lys Leu Phe Pro Ser Ile Ile Ser Ile Thr Trp Pro Leu Leu           
    450                 455                 460                           

ttc ttt gaa tat gaa ggg aac ttc atc cag aag ttc cag cgt gag cta       1440
Phe Phe Glu Tyr Glu Gly Asn Phe Ile Gln Lys Phe Gln Arg Glu Leu           
465                 470                 475                 480           

agc acc aaa tgg gtg ctg aat aca gtg agt aca ggt gct cat gtg ctt       1488
Ser Thr Lys Trp Val Leu Asn Thr Val Ser Thr Gly Ala His Val Leu           
                485                 490                 495               

ctt ggt aag atc cta caa aac cac atg ttg gac ctt cgg att agc aac       1536
Leu Gly Lys Ile Leu Gln Asn His Met Leu Asp Leu Arg Ile Ser Asn           
            500                 505                 510                   

tcc aag ctc ttc tgg cgg gcg ctg gcc atg ctg cag cgg ttc tct gga       1584
Ser Lys Leu Phe Trp Arg Ala Leu Ala Met Leu Gln Arg Phe Ser Gly           
        515                 520                 525                       

cag tcc aag gct cga tgc atc gag agc ctc ctc cga gcg atc cac ttt       1632
Gln Ser Lys Ala Arg Cys Ile Glu Ser Leu Leu Arg Ala Ile His Phe           
    530                 535                 540                           

ccc cag cca ctg tca gat gat att cgg gct gct ccc atc tcc tgc cgt       1680
Pro Gln Pro Leu Ser Asp Asp Ile Arg Ala Ala Pro Ile Ser Cys Arg           
545                 550                 555                 560           

gtc cag gtt gca cat gag aag gaa cag gtg ata ccc atc gcc ttg ctg       1728
Val Gln Val Ala His Glu Lys Glu Gln Val Ile Pro Ile Ala Leu Leu           
                565                 570                 575               

agc ctc cta ttc cgg tgc tcg atc act gag gct cag gca cac ctg gct       1776
Ser Leu Leu Phe Arg Cys Ser Ile Thr Glu Ala Gln Ala His Leu Ala           
            580                 585                 590                   

gca gct cct tct gtc tgt gag gct gtc agg agt gct ctt gct ggg cca       1824
Ala Ala Pro Ser Val Cys Glu Ala Val Arg Ser Ala Leu Ala Gly Pro           
        595                 600                 605                       

ggt cag aag cgc act gcg gac ccc ctc gag atc cta gag cct gac gtt       1872
Gly Gln Lys Arg Thr Ala Asp Pro Leu Glu Ile Leu Glu Pro Asp Val           
    610                 615                 620                           

cag tga                                                               1878
Gln                                                                       
625                                                                       


<210>  2
<211>  625
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Pro Gly Thr Lys Arg Phe Gln His Val Ile Glu Thr Pro Glu Pro 
1               5                   10                  15      


Gly Lys Trp Glu Leu Ser Gly Tyr Glu Ala Ala Val Pro Ile Thr Glu 
            20                  25                  30          


Lys Ser Asn Pro Leu Thr Gln Asp Leu Asp Lys Ala Asp Ala Glu Asn 
        35                  40                  45              


Ile Val Arg Leu Leu Gly Gln Cys Asp Ala Glu Ile Phe Gln Glu Glu 
    50                  55                  60                  


Gly Gln Ala Leu Ser Thr Tyr Gln Arg Leu Tyr Ser Glu Ser Ile Leu 
65                  70                  75                  80  


Thr Thr Met Val Gln Val Ala Gly Lys Val Gln Glu Val Leu Lys Glu 
                85                  90                  95      


Pro Asp Gly Gly Leu Val Val Leu Ser Gly Gly Gly Thr Ser Gly Arg 
            100                 105                 110         


Met Ala Phe Leu Met Ser Val Ser Phe Asn Gln Leu Met Lys Gly Leu 
        115                 120                 125             


Gly Gln Lys Pro Leu Tyr Thr Tyr Leu Ile Ala Gly Gly Asp Arg Ser 
    130                 135                 140                 


Val Val Ala Ser Arg Glu Gly Thr Glu Asp Ser Ala Leu His Gly Ile 
145                 150                 155                 160 


Glu Glu Leu Lys Lys Val Ala Ala Gly Lys Lys Arg Val Ile Val Ile 
                165                 170                 175     


Gly Ile Ser Val Gly Leu Ser Ala Pro Phe Val Ala Gly Gln Met Asp 
            180                 185                 190         


Cys Cys Met Asn Asn Thr Ala Val Phe Leu Pro Val Leu Val Gly Phe 
        195                 200                 205             


Asn Pro Val Ser Met Ala Arg Asn Asp Pro Ile Glu Asp Trp Ser Ser 
    210                 215                 220                 


Thr Phe Arg Gln Val Ala Glu Arg Met Gln Lys Met Gln Glu Lys Gln 
225                 230                 235                 240 


Lys Ala Phe Val Leu Asn Pro Ala Ile Gly Pro Glu Gly Leu Ser Gly 
                245                 250                 255     


Ser Ser Arg Met Lys Gly Gly Ser Ala Thr Lys Ile Leu Leu Glu Thr 
            260                 265                 270         


Leu Leu Leu Ala Ala His Lys Thr Val Asp Gln Gly Ile Ala Ala Ser 
        275                 280                 285             


Gln Arg Cys Leu Leu Glu Ile Leu Arg Thr Phe Glu Arg Ala His Gln 
    290                 295                 300                 


Val Thr Tyr Ser Gln Ser Pro Lys Ile Ala Thr Leu Met Lys Ser Val 
305                 310                 315                 320 


Ser Thr Ser Leu Glu Lys Lys Gly His Val Tyr Leu Val Gly Trp Gln 
                325                 330                 335     


Thr Leu Gly Ile Ile Ala Ile Met Asp Gly Val Glu Cys Ile His Thr 
            340                 345                 350         


Phe Gly Ala Asp Phe Arg Asp Val Arg Gly Phe Leu Ile Gly Asp His 
        355                 360                 365             


Ser Asp Met Phe Asn Gln Lys Ala Glu Leu Thr Asn Gln Gly Pro Gln 
    370                 375                 380                 


Phe Thr Phe Ser Gln Glu Asp Phe Pro Thr Ser Ile Leu Pro Ser Leu 
385                 390                 395                 400 


Thr Glu Ile Asp Thr Val Val Phe Ile Phe Thr Leu Asp Asp Asn Leu 
                405                 410                 415     


Thr Glu Val Gln Thr Ile Val Glu Gln Val Lys Glu Lys Thr Asn His 
            420                 425                 430         


Ile Gln Ala Leu Ala His Ser Thr Val Gly Gln Thr Leu Pro Ile Pro 
        435                 440                 445             


Leu Lys Lys Leu Phe Pro Ser Ile Ile Ser Ile Thr Trp Pro Leu Leu 
    450                 455                 460                 


Phe Phe Glu Tyr Glu Gly Asn Phe Ile Gln Lys Phe Gln Arg Glu Leu 
465                 470                 475                 480 


Ser Thr Lys Trp Val Leu Asn Thr Val Ser Thr Gly Ala His Val Leu 
                485                 490                 495     


Leu Gly Lys Ile Leu Gln Asn His Met Leu Asp Leu Arg Ile Ser Asn 
            500                 505                 510         


Ser Lys Leu Phe Trp Arg Ala Leu Ala Met Leu Gln Arg Phe Ser Gly 
        515                 520                 525             


Gln Ser Lys Ala Arg Cys Ile Glu Ser Leu Leu Arg Ala Ile His Phe 
    530                 535                 540                 


Pro Gln Pro Leu Ser Asp Asp Ile Arg Ala Ala Pro Ile Ser Cys Arg 
545                 550                 555                 560 


Val Gln Val Ala His Glu Lys Glu Gln Val Ile Pro Ile Ala Leu Leu 
                565                 570                 575     


Ser Leu Leu Phe Arg Cys Ser Ile Thr Glu Ala Gln Ala His Leu Ala 
            580                 585                 590         


Ala Ala Pro Ser Val Cys Glu Ala Val Arg Ser Ala Leu Ala Gly Pro 
        595                 600                 605             


Gly Gln Lys Arg Thr Ala Asp Pro Leu Glu Ile Leu Glu Pro Asp Val 
    610                 615                 620                 


Gln 
625 


<210>  3
<211>  7304
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  plsmido comercial pGBKT7

<400>  3
cggtgcgggc ctcttcgcta ttacgccaga tccttttgtt gtttccgggt gtacaatatg       60

gacttcctct tttctggcaa ccaaacccat acatcgggat tcctataata ccttcgttgg      120

tctccctaac atgtaggtgg cggaggggag atatacaata gaacagatac cagacaagac      180

ataatgggct aaacaagact acaccaatta cactgcctca ttgatggtgg tacataacga      240

actaatactg tagccctaga cttgatagcc atcatcatat cgaagtttca ctaccctttt      300

tccatttgcc atctattgaa gtaataatag gcgcatgcaa cttcttttct ttttttttct      360

tttctctctc ccccgttgtt gtctcaccat atccgcaatg acaaaaaaaa tgatggaaga      420

cactaaagga aaaaattaac gacaaagaca gcaccaacag atgtcgttgt tccagagctg      480

atgaggggta tctcgaagca cacgaaactt tttccttcct tcattcacgc acactactct      540

ctaatgagca acggtatacg gccttccttc cagttacttg aatttgaaat aaaaaaagtt      600

tgctgtcttg ctatcaagta taaatagacc tgcaattatt aatcttttgt ttcctcgtca      660

ttgttctcgt tccctttctt ccttgtttct ttttctgcac aatatttcaa gctataccaa      720

gcatacaatc aactccaagc ttgaagcaag cctcctgaaa gatgaagcta ctgtcttcta      780

tcgaacaagc atgcgatatt tgccgactta aaaagctcaa gtgctccaaa gaaaaaccga      840

agtgcgccaa gtgtctgaag aacaactggg agtgtcgcta ctctcccaaa accaaaaggt      900

ctccgctgac tagggcacat ctgacagaag tggaatcaag gctagaaaga ctggaacagc      960

tatttctact gatttttcct cgagaagacc ttgacatgat tttgaaaatg gattctttac     1020

aggatataaa agcattgtta acaggattat ttgtacaaga taatgtgaat aaagatgccg     1080

tcacagatag attggcttca gtggagactg atatgcctct aacattgaga cagcatagaa     1140

taagtgcgac atcatcatcg gaagagagta gtaacaaagg tcaaagacag ttgactgtat     1200

cgccggaatt tgtaatacga ctcactatag ggcgagccgc catcatggag gagcagaagc     1260

tgatctcaga ggaggacctg catatggcca tggaggccga attcccgggg atccgtcgac     1320

ctgcagcggc cgcataacta gcataacccc ttggggcctc taaacgggtc ttgaggggtt     1380

ttttgcgcgc ttgcagccaa gctaattccg ggcgaatttc ttatgattta tgatttttat     1440

tattaaataa gttataaaaa aaataagtgt atacaaattt taaagtgact cttaggtttt     1500

aaaacgaaaa ttcttattct tgagtaactc tttcctgtag gtcaggttgc tttctcaggt     1560

atagcatgag gtcgctctta ttgaccacac ctctaccggc atgcaagctt ggcgtaatca     1620

tggtcatagc tgtttcctgt gtgaaattgt tatccgctca caattccaca caacatacga     1680

gccggaagca taaagtgtaa agcctggggt gcctaatgag tgaggtaact cacattaatt     1740

gcgttgcgct cactgcccgc tttccagtcg ggaaacctgt cgtgccagct gcattaatga     1800

atcggccaac gcgcggggag aggcggtttg cgtattgggc gctcttccgc ttcctcgctc     1860

actgactcgc tgcgctcggt cgttcggctg cggcgagcgg tatcagctca ctcaaaggcg     1920

gtaatacggt tatccacaga atcaggggat aacgcaggaa agaacatgtg agcaaaaggc     1980

cagcaaaagg ccaggaaccg taaaaaggcc gcgttgctgg cgtttttcca taggctccgc     2040

ccccctgacg agcatcacaa aaatcgacgc tcaagtcaga ggtggcgaaa cccgacagga     2100

ctataaagat accaggcgtt tccccctgga agctccctcg tgcgctctcc tgttccgacc     2160

ctgccgctta ccggatacct gtccgccttt ctcccttcgg gaagcgtggc gctttctcat     2220

agctcacgct gtaggtatct cagttcggtg taggtcgttc gctccaagct gggctgtgtg     2280

cacgaacccc ccgttcagcc cgaccgctgc gccttatccg gtaactatcg tcttgagtcc     2340

aacccggtaa gacacgactt atcgccactg gcagcagcca ctggtaacag gattagcaga     2400

gcgaggtatg taggcggtgc tacagagttc ttgaagtggt ggcctaacta cggctacact     2460

agaaggacag tatttggtat ctgcgctctg ctgaagccag ttaccttcgg aaaaagagtt     2520

ggtagctctt gatccggcaa acaaaccacc gctggtagcg gtggtttttt tgtttgcaag     2580

cagcagatta cgcgcagaaa aaaaggatct caagaagatc ctttgatctt ttctacgggg     2640

tctgacgctc agtggaacga aaactcacgt taagggattt tggtcatgag attatcaaaa     2700

aggatcttca cctagatcct tttaaattaa aaatgaagtt ttaaatcaat ctaaagtata     2760

tatgagtaac ctgaggctat ggcagggcct gccgccccga cgttggctgc gagccctggg     2820

ccttcacccg aacttggggg gtggggtggg gaaaaggaag aaacgcgggc gtattggccc     2880

caatggggtc tcggtggggt atcgacagag tgccagccct gggaccgaac cccgcgttta     2940

tgaacaaacg acccaacacc gtgcgtttta ttctgtcttt ttattgccgt catagcgcgg     3000

gttccttccg gtattgtctc cttccgtgtt tcagttagcc tccccctagg gtgggcgaag     3060

aactccagca tgagatcccc gcgctggagg atcatccagc cggcgtcccg gaaaacgatt     3120

ccgaagccca acctttcata gaaggcggcg gtggaatcga aatctcgtga tggcaggttg     3180

ggcgtcgctt ggtcggttca tttcgaaccc cagagtcccg ctcagaagaa ctcgtcaaga     3240

aggcgataga aggcgatgcg ctgcgaatcg ggagcggcga taccgtaaag cacgaggaag     3300

cggtcagccc attcgccgcc aagctcttca gcaatatcac gggtagccaa cgctatgtcc     3360

tgatagcggt ccgccacacc cagccggcca cagtcgatga atccagaaaa gcggccattt     3420

tccaccatga tattcggcaa gcaggcatcg tcatgggtca cgacgagatc ctcgccgtcg     3480

ggcatgctcg ccttgagcct ggcgaacagt tcggctggcg cgagcccctg atgctcttcg     3540

tccagatcat cctgatcgac aagaccggct tccatccgag tacgtgctcg ctcgatgcga     3600

tgtttcgctt ggtggtcgaa tgggcaggta gccggatcaa gcgtatgcag ccgccgcatt     3660

gcatcagcca tgatggatac tttctcggca ggagcaaggt gagatgacag gagatcctgc     3720

cccggcactt cgcccaatag cagccagtcc cttcccgctt cagtgacaac gtcgagcaca     3780

gctgcgcaag gaacgcccgt cgtggccagc cacgatagcc gcgctgcctc gtcttgcagt     3840

tcattcaggg caccggacag gtcggtcttg acaaaaagaa ccgggcgccc ctgcgctgac     3900

agccggaaca cggcggcatc agagcagccg attgtctgtt gtgcccagtc atagccgaat     3960

agcctctcca cccaagcggc cggagaacct gcgtgcaatc catcttgttc aatcatactc     4020

ttcctttttc aatattattg aagcatttat cagggttatt gtctcatgag cggatacata     4080

tttgaatgta tttagaaaaa taaacaaata ggggttccgc gcacatttcc ccgaaaagtg     4140

ccacctgaac gaagcatctg tgcttcattt tgtagaacaa aaatgcaacg cgagagcgct     4200

aatttttcaa acaaagaatc tgagctgcat ttttacagaa cagaaatgca acgcgaaagc     4260

gctattttac caacgaagaa tctgtgcttc atttttgtaa aacaaaaatg caacgcgaga     4320

gcgctaattt ttcaaacaaa gaatctgagc tgcattttta cagaacagaa atgcaacgcg     4380

agagcgctat tttaccaaca aagaatctat acttcttttt tgttctacaa aaatgcatcc     4440

cgagagcgct atttttctaa caaagcatct tagattactt tttttctcct ttgtgcgctc     4500

tataatgcag tctcttgata actttttgca ctgtaggtcc gttaaggtta gaagaaggct     4560

actttggtgt ctattttctc ttccataaaa aaagcctgac tccacttccc gcgtttactg     4620

attactagcg aagctgcggg tgcatttttt caagataaag gcatccccga ttatattcta     4680

taccgatgtg gattgcgcat actttgtgaa cagaaagtga tagcgttgat gattcttcat     4740

tggtcagaaa attatgaacg gtttcttcta ttttgtctct atatactacg tataggaaat     4800

gtttacattt tcgtattgtt ttcgattcac tctatgaata gttcttacta caattttttt     4860

gtctaaagag taatactaga gataaacata aaaaatgtag aggtcgagtt tagatgcaag     4920

ttcaaggagc gaaaggtgga tgggtaggtt atatagggat atagcacaga gatatatagc     4980

aaagagatac ttttgagcaa tgtttgtgga agcggtattc gcaatatttt agtagctcgt     5040

tacagtccgg tgcgtttttg gttttttgaa agtgcgtctt cagagcgctt ttggttttca     5100

aaagcgctct gaagttccta tactttctag agaataggaa cttcggaata ggaacttcaa     5160

agcgtttccg aaaacgagcg cttccgaaaa tgcaacgcga gctgcgcaca tacagctcac     5220

tgttcacgtc gcacctatat ctgcgtgttg cctgtatata tatatacatg agaagaacgg     5280

catagtgcgt gtttatgctt aaatgcgtac ttatatgcgt ctatttatgt aggatgaaag     5340

gtagtctagt acctcctgtg atattatccc attccatgcg gggtatcgta tgcttccttc     5400

agcactaccc tttagctgtt ctatatgctg ccactcctca attggattag tctcatcctt     5460

caatgctatc atttcctttg atattggatc atattaagaa accattatta tcatgacatt     5520

aacctataaa aataggcgta tcacgaggcc ctttcgtctc gcgcgtttcg gtgatgacgg     5580

tgaaaacctc tgacacatgc agctcccgga gacggtcaca gcttgtctgt aagcggatgc     5640

cgggagcaga caagcccgtc agggcgcgtc agcgggtgtt ggcgggtgtc ggggctggct     5700

taactatgcg gcatcagagc agattgtact gagagtgcac catagatcaa cgacattact     5760

atatatataa tataggaagc atttaataga acagcatcgt aatatatgtg tactttgcag     5820

ttatgacgcc agatggcagt agtggaagat attctttatt gaaaaatagc ttgtcacctt     5880

acgtacaatc ttgatccgga gcttttcttt ttttgccgat taagaattaa ttcggtcgaa     5940

aaaagaaaag gagagggcca agagggaggg cattggtgac tattgagcac gtgagtatac     6000

gtgattaagc acacaaaggc agcttggagt atgtctgtta ttaatttcac aggtagttct     6060

ggtccattgg tgaaagtttg cggcttgcag agcacagagg ccgcagaatg tgctctagat     6120

tccgatgctg acttgctggg tattatatgt gtgcccaata gaaagagaac aattgacccg     6180

gttattgcaa ggaaaatttc aagtcttgta aaagcatata aaaatagttc aggcactccg     6240

aaatacttgg ttggcgtgtt tcgtaatcaa cctaaggagg atgttttggc tctggtcaat     6300

gattacggca ttgatatcgt ccaactgcat ggagatgagt cgtggcaaga ataccaagag     6360

ttcctcggtt tgccagttat taaaagactc gtatttccaa aagactgcaa catactactc     6420

agtgcagctt cacagaaacc tcattcgttt attcccttgt ttgattcaga agcaggtggg     6480

acaggtgaac ttttggattg gaactcgatt tctgactggg ttggaaggca agagagcccc     6540

gaaagcttac attttatgtt agctggtgga ctgacgccag aaaatgttgg tgatgcgctt     6600

agattaaatg gcgttattgg tgttgatgta agcggaggtg tggagacaaa tggtgtaaaa     6660

gactctaaca aaatagcaaa tttcgtcaaa aatgctaaga aataggttat tactgagtag     6720

tatttattta agtattgttt gtgcacttgc cgatctatgc ggtgtgaaat accgcacaga     6780

tgcgtaagga gaaaataccg catcaggaaa ttgtaaacgt taatattttg ttaaaattcg     6840

cgttaaattt ttgttaaatc agctcatttt ttaaccaata ggccgaaatc ggcaaaatcc     6900

cttataaatc aaaagaatag accgagatag ggttgagtgt tgttccagtt tggaacaaga     6960

gtccactatt aaagaacgtg gactccaacg tcaaagggcg aaaaaccgtc tatcagggcg     7020

atggcccact acgtgaacca tcaccctaat caagtttttt ggggtcgagg tgccgtaaag     7080

cactaaatcg gaaccctaaa gggagccccc gatttagagc ttgacgggga aagccggcga     7140

acgtggcgag aaaggaaggg aagaaagcga aaggagcggg cgctagggcg ctggcaagtg     7200

tagcggtcac gctgcgcgta accaccacac ccgccgcgct taatgcgccg ctacagggcg     7260

cgtccattcg ccattcaggc tgcgcaactg ttgggaaggg cgat                      7304


<210>  4
<211>  440
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Dominio de unin a Gal4 (GBD-Gal4 Binding Domain)

<400>  4
atgaagctac tgtcttctat cgaacaagca tgcgatattt gccgacttaa aaagccaagt       60

gctccaaaga aaaaccgaag tgcgccaagt gtctgaagaa caactgggag tgtcgctact      120

ctcccaaaac caaaaggtct ccgctgacta gggcacatct gacagaagtg gaatcaaggc      180

tagaaagact ggaacagcta tttctactga tttttcctcg agaagacctt gacatgattt      240

tgaaaatgga ttctttacag gatataaaag cattgttaac aggattattt gtacaagata      300

atgtgaataa agatgccgtc acagatagat tggcttcagt ggagactgat atgcctctaa      360

cattgagaca gcatagaata agtgcgacat catcatcgga agagagtagt aacaaaggtc      420

aaagacagtt gactgtatcg                                                  440


<210>  5
<211>  705
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Promotor ADH1

<400>  5
atccttttgt tgtttccggg tgtacaatat ggacttcctc ttttctggca accaaaccca       60

tacatcggga ttcctataat accttcgttg gtctccctaa catgtaggtg gcggagggga      120

gatatacaat agaacagata ccagacaaga cataatgggc taaacaagac tacaccaatt      180

acactgcctc attgatggtg gtacataacg aactaatact gtagccctag acttgatagc      240

catcatcata tcgaagtttc actacccttt ttccatttgc catctattga agtaataata      300

ggcgcatgca acttcttttc tttttttttc ttttctctct cccccgttgt tgtctcacca      360

tatccgcaat gacaaaaaaa atgatggaag acactaaagg aaaaaattaa cgacaaagac      420

agcaccaaca gatgtcgttg ttccagagct gatgaggggt atctcgaagc acacgaaact      480

ttttccttcc ttcattcacg cacactactc tctaatgagc aacggtatac ggccttcctt      540

ccagttactt gaatttgaaa taaaaaaagt ttgctgtctt gctatcaagt ataaatagac      600

ctgcaattat taatcttttg tttcctcgtc attgttctcg ttccctttct tccttgtttc      660

tttttctgca caatatttca agctatacca agcatacaat caact                      705


<210>  6
<211>  9177
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  plsmido pGBKT7-GKRP

<400>  6
cggtgcgggc ctcttcgcta ttacgccaga tccttttgtt gtttccgggt gtacaatatg       60

gacttcctct tttctggcaa ccaaacccat acatcgggat tcctataata ccttcgttgg      120

tctccctaac atgtaggtgg cggaggggag atatacaata gaacagatac cagacaagac      180

ataatgggct aaacaagact acaccaatta cactgcctca ttgatggtgg tacataacga      240

actaatactg tagccctaga cttgatagcc atcatcatat cgaagtttca ctaccctttt      300

tccatttgcc atctattgaa gtaataatag gcgcatgcaa cttcttttct ttttttttct      360

tttctctctc ccccgttgtt gtctcaccat atccgcaatg acaaaaaaaa tgatggaaga      420

cactaaagga aaaaattaac gacaaagaca gcaccaacag atgtcgttgt tccagagctg      480

atgaggggta tctcgaagca cacgaaactt tttccttcct tcattcacgc acactactct      540

ctaatgagca acggtatacg gccttccttc cagttacttg aatttgaaat aaaaaaagtt      600

tgctgtcttg ctatcaagta taaatagacc tgcaattatt aatcttttgt ttcctcgtca      660

ttgttctcgt tccctttctt ccttgtttct ttttctgcac aatatttcaa gctataccaa      720

gcatacaatc aactccaagc ttgaagcaag cctcctgaaa gatgaagcta ctgtcttcta      780

tcgaacaagc atgcgatatt tgccgactta aaaagctcaa gtgctccaaa gaaaaaccga      840

agtgcgccaa gtgtctgaag aacaactggg agtgtcgcta ctctcccaaa accaaaaggt      900

ctccgctgac tagggcacat ctgacagaag tggaatcaag gctagaaaga ctggaacagc      960

tatttctact gatttttcct cgagaagacc ttgacatgat tttgaaaatg gattctttac     1020

aggatataaa agcattgtta acaggattat ttgtacaaga taatgtgaat aaagatgccg     1080

tcacagatag attggcttca gtggagactg atatgcctct aacattgaga cagcatagaa     1140

taagtgcgac atcatcatcg gaagagagta gtaacaaagg tcaaagacag ttgactgtat     1200

cgccggaatt tgtaatacga ctcactatag ggcgagccgc catcatggag gagcagaagc     1260

tgatctcaga ggaggacctg catatggcca tggaggccga attcatgcca ggcacaaaac     1320

ggtttcaaca tgtcattgag accccggagc ctggcaagtg ggagttgtct gggtacgagg     1380

cagctgtgcc aatcacggag aagtcaaacc cactgaccca ggatctagac aaagcagatg     1440

ctgagaacat tgttcgactg ctagggcaat gtgatgctga gatcttccag gaggaggggc     1500

aagccctgtc cacataccag agactctaca gcgaatccat tctgaccacc atggtacagg     1560

tggctgggaa agttcaggaa gtgctgaagg agccagatgg ggggctggtt gtgctgagtg     1620

gagggggcac ctctggccgg atggcattcc tcatgtcggt gtcctttaat cagctgatga     1680

aaggtctggg acagaaacct ctttacacct acctcattgc aggtggtgac aggtctgtgg     1740

tggcctctag ggaggggaca gaagatagtg ccttgcacgg gattgaggaa ctgaagaagg     1800

tggctgccgg gaagaagaga gtgattgtca ttggcatttc tgtgggactc tctgctccct     1860

ttgtggcagg ccagatggac tgctgcatga acaacacagc tgtcttcttg ccagtcctgg     1920

ttggcttcaa tccagtgagc atggccagaa atgaccccat tgaagactgg agttcaacat     1980

tccgacaagt agcagagcgg atgcagaaaa tgcaggagaa acagaaagct tttgtgctca     2040

atcctgccat cgggcccgag ggtctcagcg gctcctcccg gatgaaaggt ggaagtgcca     2100

ccaagattct gctggaaacc ctgttattag cagcccataa gactgtggac cagggcattg     2160

cagcatctca aagatgcctc ctggaaatct tgcggacatt tgagcgagct catcaggtga     2220

cctacagcca aagccccaag attgccaccc tgatgaagag tgtcagcacc agtctggaga     2280

agaaaggcca cgtgtacctg gttggctggc agaccctggg tatcattgcc atcatggatg     2340

gagtagagtg catccacacc tttggtgctg atttccgaga tgtccgtggc tttctcattg     2400

gtgatcacag tgacatgttt aaccagaagg ctgagctcac caaccagggt ccccagttca     2460

ccttctccca ggaggacttc ccgacttcca tccttccctc tctcacggaa atcgatactg     2520

tggtcttcat tttcaccctg gatgacaacc tcacggaggt gcagactata gtggagcagg     2580

tgaaagagaa gaccaaccac atccaggccc tggcacacag caccgtgggt cagaccttgc     2640

cgatccctct gaagaagctc tttccctcca tcatcagcat cacatggcca ctgcttttct     2700

ttgaatatga agggaacttc atccagaagt tccagcgtga gctaagcacc aaatgggtgc     2760

tgaatacagt gagtacaggt gctcatgtgc ttcttggtaa gatcctacaa aaccacatgt     2820

tggaccttcg gattagcaac tccaagctct tctggcgggc gctggccatg ctgcagcggt     2880

tctctggaca gtccaaggct cgatgcatcg agagcctcct ccgagcgatc cactttcccc     2940

agccactgtc agatgatatt cgggctgctc ccatctcctg ccgtgtccag gttgcacatg     3000

agaaggaaca ggtgataccc atcgccttgc tgagcctcct attccggtgc tcgatcactg     3060

aggctcaggc acacctggct gcagctcctt ctgtctgtga ggctgtcagg agtgctcttg     3120

ctgggccagg tcagaagcgc actgcggacc ccctcgagat cctagagcct gacgttcagt     3180

aggatccgtc gacctgcagc ggccgcataa ctagcataac cccttggggc ctctaaacgg     3240

gtcttgaggg gttttttgcg cgcttgcagc caagctaatt ccgggcgaat ttcttatgat     3300

ttatgatttt tattattaaa taagttataa aaaaaataag tgtatacaaa ttttaaagtg     3360

actcttaggt tttaaaacga aaattcttat tcttgagtaa ctctttcctg taggtcaggt     3420

tgctttctca ggtatagcat gaggtcgctc ttattgacca cacctctacc ggcatgcaag     3480

cttggcgtaa tcatggtcat agctgtttcc tgtgtgaaat tgttatccgc tcacaattcc     3540

acacaacata cgagccggaa gcataaagtg taaagcctgg ggtgcctaat gagtgaggta     3600

actcacatta attgcgttgc gctcactgcc cgctttccag tcgggaaacc tgtcgtgcca     3660

gctgcattaa tgaatcggcc aacgcgcggg gagaggcggt ttgcgtattg ggcgctcttc     3720

cgcttcctcg ctcactgact cgctgcgctc ggtcgttcgg ctgcggcgag cggtatcagc     3780

tcactcaaag gcggtaatac ggttatccac agaatcaggg gataacgcag gaaagaacat     3840

gtgagcaaaa ggccagcaaa aggccaggaa ccgtaaaaag gccgcgttgc tggcgttttt     3900

ccataggctc cgcccccctg acgagcatca caaaaatcga cgctcaagtc agaggtggcg     3960

aaacccgaca ggactataaa gataccaggc gtttccccct ggaagctccc tcgtgcgctc     4020

tcctgttccg accctgccgc ttaccggata cctgtccgcc tttctccctt cgggaagcgt     4080

ggcgctttct catagctcac gctgtaggta tctcagttcg gtgtaggtcg ttcgctccaa     4140

gctgggctgt gtgcacgaac cccccgttca gcccgaccgc tgcgccttat ccggtaacta     4200

tcgtcttgag tccaacccgg taagacacga cttatcgcca ctggcagcag ccactggtaa     4260

caggattagc agagcgaggt atgtaggcgg tgctacagag ttcttgaagt ggtggcctaa     4320

ctacggctac actagaagga cagtatttgg tatctgcgct ctgctgaagc cagttacctt     4380

cggaaaaaga gttggtagct cttgatccgg caaacaaacc accgctggta gcggtggttt     4440

ttttgtttgc aagcagcaga ttacgcgcag aaaaaaagga tctcaagaag atcctttgat     4500

cttttctacg gggtctgacg ctcagtggaa cgaaaactca cgttaaggga ttttggtcat     4560

gagattatca aaaaggatct tcacctagat ccttttaaat taaaaatgaa gttttaaatc     4620

aatctaaagt atatatgagt aacctgaggc tatggcaggg cctgccgccc cgacgttggc     4680

tgcgagccct gggccttcac ccgaacttgg ggggtggggt ggggaaaagg aagaaacgcg     4740

ggcgtattgg ccccaatggg gtctcggtgg ggtatcgaca gagtgccagc cctgggaccg     4800

aaccccgcgt ttatgaacaa acgacccaac accgtgcgtt ttattctgtc tttttattgc     4860

cgtcatagcg cgggttcctt ccggtattgt ctccttccgt gtttcagtta gcctccccct     4920

agggtgggcg aagaactcca gcatgagatc cccgcgctgg aggatcatcc agccggcgtc     4980

ccggaaaacg attccgaagc ccaacctttc atagaaggcg gcggtggaat cgaaatctcg     5040

tgatggcagg ttgggcgtcg cttggtcggt tcatttcgaa ccccagagtc ccgctcagaa     5100

gaactcgtca agaaggcgat agaaggcgat gcgctgcgaa tcgggagcgg cgataccgta     5160

aagcacgagg aagcggtcag cccattcgcc gccaagctct tcagcaatat cacgggtagc     5220

caacgctatg tcctgatagc ggtccgccac acccagccgg ccacagtcga tgaatccaga     5280

aaagcggcca ttttccacca tgatattcgg caagcaggca tcgtcatggg tcacgacgag     5340

atcctcgccg tcgggcatgc tcgccttgag cctggcgaac agttcggctg gcgcgagccc     5400

ctgatgctct tcgtccagat catcctgatc gacaagaccg gcttccatcc gagtacgtgc     5460

tcgctcgatg cgatgtttcg cttggtggtc gaatgggcag gtagccggat caagcgtatg     5520

cagccgccgc attgcatcag ccatgatgga tactttctcg gcaggagcaa ggtgagatga     5580

caggagatcc tgccccggca cttcgcccaa tagcagccag tcccttcccg cttcagtgac     5640

aacgtcgagc acagctgcgc aaggaacgcc cgtcgtggcc agccacgata gccgcgctgc     5700

ctcgtcttgc agttcattca gggcaccgga caggtcggtc ttgacaaaaa gaaccgggcg     5760

cccctgcgct gacagccgga acacggcggc atcagagcag ccgattgtct gttgtgccca     5820

gtcatagccg aatagcctct ccacccaagc ggccggagaa cctgcgtgca atccatcttg     5880

ttcaatcata ctcttccttt ttcaatatta ttgaagcatt tatcagggtt attgtctcat     5940

gagcggatac atatttgaat gtatttagaa aaataaacaa ataggggttc cgcgcacatt     6000

tccccgaaaa gtgccacctg aacgaagcat ctgtgcttca ttttgtagaa caaaaatgca     6060

acgcgagagc gctaattttt caaacaaaga atctgagctg catttttaca gaacagaaat     6120

gcaacgcgaa agcgctattt taccaacgaa gaatctgtgc ttcatttttg taaaacaaaa     6180

atgcaacgcg agagcgctaa tttttcaaac aaagaatctg agctgcattt ttacagaaca     6240

gaaatgcaac gcgagagcgc tattttacca acaaagaatc tatacttctt ttttgttcta     6300

caaaaatgca tcccgagagc gctatttttc taacaaagca tcttagatta ctttttttct     6360

cctttgtgcg ctctataatg cagtctcttg ataacttttt gcactgtagg tccgttaagg     6420

ttagaagaag gctactttgg tgtctatttt ctcttccata aaaaaagcct gactccactt     6480

cccgcgttta ctgattacta gcgaagctgc gggtgcattt tttcaagata aaggcatccc     6540

cgattatatt ctataccgat gtggattgcg catactttgt gaacagaaag tgatagcgtt     6600

gatgattctt cattggtcag aaaattatga acggtttctt ctattttgtc tctatatact     6660

acgtatagga aatgtttaca ttttcgtatt gttttcgatt cactctatga atagttctta     6720

ctacaatttt tttgtctaaa gagtaatact agagataaac ataaaaaatg tagaggtcga     6780

gtttagatgc aagttcaagg agcgaaaggt ggatgggtag gttatatagg gatatagcac     6840

agagatatat agcaaagaga tacttttgag caatgtttgt ggaagcggta ttcgcaatat     6900

tttagtagct cgttacagtc cggtgcgttt ttggtttttt gaaagtgcgt cttcagagcg     6960

cttttggttt tcaaaagcgc tctgaagttc ctatactttc tagagaatag gaacttcgga     7020

ataggaactt caaagcgttt ccgaaaacga gcgcttccga aaatgcaacg cgagctgcgc     7080

acatacagct cactgttcac gtcgcaccta tatctgcgtg ttgcctgtat atatatatac     7140

atgagaagaa cggcatagtg cgtgtttatg cttaaatgcg tacttatatg cgtctattta     7200

tgtaggatga aaggtagtct agtacctcct gtgatattat cccattccat gcggggtatc     7260

gtatgcttcc ttcagcacta ccctttagct gttctatatg ctgccactcc tcaattggat     7320

tagtctcatc cttcaatgct atcatttcct ttgatattgg atcatattaa gaaaccatta     7380

ttatcatgac attaacctat aaaaataggc gtatcacgag gccctttcgt ctcgcgcgtt     7440

tcggtgatga cggtgaaaac ctctgacaca tgcagctccc ggagacggtc acagcttgtc     7500

tgtaagcgga tgccgggagc agacaagccc gtcagggcgc gtcagcgggt gttggcgggt     7560

gtcggggctg gcttaactat gcggcatcag agcagattgt actgagagtg caccatagat     7620

caacgacatt actatatata taatatagga agcatttaat agaacagcat cgtaatatat     7680

gtgtactttg cagttatgac gccagatggc agtagtggaa gatattcttt attgaaaaat     7740

agcttgtcac cttacgtaca atcttgatcc ggagcttttc tttttttgcc gattaagaat     7800

taattcggtc gaaaaaagaa aaggagaggg ccaagaggga gggcattggt gactattgag     7860

cacgtgagta tacgtgatta agcacacaaa ggcagcttgg agtatgtctg ttattaattt     7920

cacaggtagt tctggtccat tggtgaaagt ttgcggcttg cagagcacag aggccgcaga     7980

atgtgctcta gattccgatg ctgacttgct gggtattata tgtgtgccca atagaaagag     8040

aacaattgac ccggttattg caaggaaaat ttcaagtctt gtaaaagcat ataaaaatag     8100

ttcaggcact ccgaaatact tggttggcgt gtttcgtaat caacctaagg aggatgtttt     8160

ggctctggtc aatgattacg gcattgatat cgtccaactg catggagatg agtcgtggca     8220

agaataccaa gagttcctcg gtttgccagt tattaaaaga ctcgtatttc caaaagactg     8280

caacatacta ctcagtgcag cttcacagaa acctcattcg tttattccct tgtttgattc     8340

agaagcaggt gggacaggtg aacttttgga ttggaactcg atttctgact gggttggaag     8400

gcaagagagc cccgaaagct tacattttat gttagctggt ggactgacgc cagaaaatgt     8460

tggtgatgcg cttagattaa atggcgttat tggtgttgat gtaagcggag gtgtggagac     8520

aaatggtgta aaagactcta acaaaatagc aaatttcgtc aaaaatgcta agaaataggt     8580

tattactgag tagtatttat ttaagtattg tttgtgcact tgccgatcta tgcggtgtga     8640

aataccgcac agatgcgtaa ggagaaaata ccgcatcagg aaattgtaaa cgttaatatt     8700

ttgttaaaat tcgcgttaaa tttttgttaa atcagctcat tttttaacca ataggccgaa     8760

atcggcaaaa tcccttataa atcaaaagaa tagaccgaga tagggttgag tgttgttcca     8820

gtttggaaca agagtccact attaaagaac gtggactcca acgtcaaagg gcgaaaaacc     8880

gtctatcagg gcgatggccc actacgtgaa ccatcaccct aatcaagttt tttggggtcg     8940

aggtgccgta aagcactaaa tcggaaccct aaagggagcc cccgatttag agcttgacgg     9000

ggaaagccgg cgaacgtggc gagaaaggaa gggaagaaag cgaaaggagc gggcgctagg     9060

gcgctggcaa gtgtagcggt cacgctgcgc gtaaccacca cacccgccgc gcttaatgcg     9120

ccgctacagg gcgcgtccat tcgccattca ggctgcgcaa ctgttgggaa gggcgat        9177


<210>  7
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Cebador hGKRP-EcoR1

<400>  7
ggaattcatg ccaggcacaa aacggtttc                                         29


<210>  8
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Cebador hGKRP-BamH1

<400>  8
gggatcctac tgaacgtcag gctctaggat ttc                                    33


<210>  9
<211>  1398
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(1398)

<400>  9
atg ctg gac gac aga gcc agg atg gag gcc gcc aag aag gag aag gta         48
Met Leu Asp Asp Arg Ala Arg Met Glu Ala Ala Lys Lys Glu Lys Val           
1               5                   10                  15                

gag cag atc ctg gca gag ttc cag ctg cag gag gag gac ctg aag aag         96
Glu Gln Ile Leu Ala Glu Phe Gln Leu Gln Glu Glu Asp Leu Lys Lys           
            20                  25                  30                    

gtg atg aga cgg atg cag aag gag atg gac cgc ggc ctg agg ctg gag        144
Val Met Arg Arg Met Gln Lys Glu Met Asp Arg Gly Leu Arg Leu Glu           
        35                  40                  45                        

acc cat gaa gag gcc agt gtg aag atg ctg ccc acc tac gtg cgc tcc        192
Thr His Glu Glu Ala Ser Val Lys Met Leu Pro Thr Tyr Val Arg Ser           
    50                  55                  60                            

acc cca gaa ggc tca gaa gtc ggg gac ttc ctc tcc ctg gac ctg ggt        240
Thr Pro Glu Gly Ser Glu Val Gly Asp Phe Leu Ser Leu Asp Leu Gly           
65                  70                  75                  80            

ggc act aac ttc agg gtg atg ctg gtg aag gtg gga gaa ggt gag gag        288
Gly Thr Asn Phe Arg Val Met Leu Val Lys Val Gly Glu Gly Glu Glu           
                85                  90                  95                

ggg cag tgg agc gtg aag acc aaa cac cag atg tac tcc atc ccc gag        336
Gly Gln Trp Ser Val Lys Thr Lys His Gln Met Tyr Ser Ile Pro Glu           
            100                 105                 110                   

gac gcc atg acc ggc act gct gag atg ctc ttc gac tac atc tct gag        384
Asp Ala Met Thr Gly Thr Ala Glu Met Leu Phe Asp Tyr Ile Ser Glu           
        115                 120                 125                       

tgc atc tcc gac ttc ctg gac aag cat cag atg aaa cac aag aag ctg        432
Cys Ile Ser Asp Phe Leu Asp Lys His Gln Met Lys His Lys Lys Leu           
    130                 135                 140                           

ccc ctg ggc ttc acc ttc tcc ttt cct gtg agg cac gaa gac atc gat        480
Pro Leu Gly Phe Thr Phe Ser Phe Pro Val Arg His Glu Asp Ile Asp           
145                 150                 155                 160           

aag ggc atc ctt ctc aac tgg acc aag ggc ttc aag gcc tca gga gca        528
Lys Gly Ile Leu Leu Asn Trp Thr Lys Gly Phe Lys Ala Ser Gly Ala           
                165                 170                 175               

gaa ggg aac aat gtc gtg ggg ctt ctg cga gac gct atc aaa cgg aga        576
Glu Gly Asn Asn Val Val Gly Leu Leu Arg Asp Ala Ile Lys Arg Arg           
            180                 185                 190                   

ggg gac ttt gaa atg gat gtg gtg gca atg gtg aat gac acg gtg gcc        624
Gly Asp Phe Glu Met Asp Val Val Ala Met Val Asn Asp Thr Val Ala           
        195                 200                 205                       

acg atg atc tcc tgc tac tac gaa gac cat cag tgc gag gtc ggc atg        672
Thr Met Ile Ser Cys Tyr Tyr Glu Asp His Gln Cys Glu Val Gly Met           
    210                 215                 220                           

atc gtg ggc acg ggc tgc aat gcc tgc tac atg gag gag atg cag aat        720
Ile Val Gly Thr Gly Cys Asn Ala Cys Tyr Met Glu Glu Met Gln Asn           
225                 230                 235                 240           

gtg gag ctg gtg gag ggg gac gag ggc cgc atg tgc gtc aat acc gag        768
Val Glu Leu Val Glu Gly Asp Glu Gly Arg Met Cys Val Asn Thr Glu           
                245                 250                 255               

tgg ggc gcc ttc ggg gac tcc ggc gag ctg gac gag ttc ctg ctg gag        816
Trp Gly Ala Phe Gly Asp Ser Gly Glu Leu Asp Glu Phe Leu Leu Glu           
            260                 265                 270                   

tat gac cgc ctg gtg gac gag agc tct gca aac ccc ggt cag cag ctg        864
Tyr Asp Arg Leu Val Asp Glu Ser Ser Ala Asn Pro Gly Gln Gln Leu           
        275                 280                 285                       

tat gag aag ctc ata ggt ggc aag tac atg ggc gag ctg gtg cgg ctt        912
Tyr Glu Lys Leu Ile Gly Gly Lys Tyr Met Gly Glu Leu Val Arg Leu           
    290                 295                 300                           

gtg ctg ctc agg ctc gtg gac gaa aac ctg ctc ttc cac ggg gag gcc        960
Val Leu Leu Arg Leu Val Asp Glu Asn Leu Leu Phe His Gly Glu Ala           
305                 310                 315                 320           

tcc gag cag ctg cgc aca cgc gga gcc ttc gag acg cgc ttc gtg tcg       1008
Ser Glu Gln Leu Arg Thr Arg Gly Ala Phe Glu Thr Arg Phe Val Ser           
                325                 330                 335               

cag gtg gag agc gac acg ggc gac cgc aag cag atc tac aac atc ctg       1056
Gln Val Glu Ser Asp Thr Gly Asp Arg Lys Gln Ile Tyr Asn Ile Leu           
            340                 345                 350                   

agc acg ctg ggg ctg cga ccc tcg acc acc gac tgc gac atc gtg cgc       1104
Ser Thr Leu Gly Leu Arg Pro Ser Thr Thr Asp Cys Asp Ile Val Arg           
        355                 360                 365                       

cgc gcc tgc gag agc gtg tct acg cgc gct gcg cac atg tgc tcg gcg       1152
Arg Ala Cys Glu Ser Val Ser Thr Arg Ala Ala His Met Cys Ser Ala           
    370                 375                 380                           

ggg ctg gcg ggc gtc atc aac cgc atg cgc gag agc cgc agc gag gac       1200
Gly Leu Ala Gly Val Ile Asn Arg Met Arg Glu Ser Arg Ser Glu Asp           
385                 390                 395                 400           

gta atg cgc atc act gtg ggc gtg gat ggc tcc gtg tac aag ctg cac       1248
Val Met Arg Ile Thr Val Gly Val Asp Gly Ser Val Tyr Lys Leu His           
                405                 410                 415               

ccc agc ttc aag gag cgg ttc cat gcc agc gtg cgc agg ctg acg ccc       1296
Pro Ser Phe Lys Glu Arg Phe His Ala Ser Val Arg Arg Leu Thr Pro           
            420                 425                 430                   

agc tgc gag atc acc ttc atc gag tcg gag gag ggc agt ggc cgg ggc       1344
Ser Cys Glu Ile Thr Phe Ile Glu Ser Glu Glu Gly Ser Gly Arg Gly           
        435                 440                 445                       

gcg gcc ctg gtc tcg gcg gtg gcc tgt aag aag gcc tgt atg ctg ggc       1392
Ala Ala Leu Val Ser Ala Val Ala Cys Lys Lys Ala Cys Met Leu Gly           
    450                 455                 460                           

cag tga                                                               1398
Gln                                                                       
465                                                                       


<210>  10
<211>  465
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Leu Asp Asp Arg Ala Arg Met Glu Ala Ala Lys Lys Glu Lys Val 
1               5                   10                  15      


Glu Gln Ile Leu Ala Glu Phe Gln Leu Gln Glu Glu Asp Leu Lys Lys 
            20                  25                  30          


Val Met Arg Arg Met Gln Lys Glu Met Asp Arg Gly Leu Arg Leu Glu 
        35                  40                  45              


Thr His Glu Glu Ala Ser Val Lys Met Leu Pro Thr Tyr Val Arg Ser 
    50                  55                  60                  


Thr Pro Glu Gly Ser Glu Val Gly Asp Phe Leu Ser Leu Asp Leu Gly 
65                  70                  75                  80  


Gly Thr Asn Phe Arg Val Met Leu Val Lys Val Gly Glu Gly Glu Glu 
                85                  90                  95      


Gly Gln Trp Ser Val Lys Thr Lys His Gln Met Tyr Ser Ile Pro Glu 
            100                 105                 110         


Asp Ala Met Thr Gly Thr Ala Glu Met Leu Phe Asp Tyr Ile Ser Glu 
        115                 120                 125             


Cys Ile Ser Asp Phe Leu Asp Lys His Gln Met Lys His Lys Lys Leu 
    130                 135                 140                 


Pro Leu Gly Phe Thr Phe Ser Phe Pro Val Arg His Glu Asp Ile Asp 
145                 150                 155                 160 


Lys Gly Ile Leu Leu Asn Trp Thr Lys Gly Phe Lys Ala Ser Gly Ala 
                165                 170                 175     


Glu Gly Asn Asn Val Val Gly Leu Leu Arg Asp Ala Ile Lys Arg Arg 
            180                 185                 190         


Gly Asp Phe Glu Met Asp Val Val Ala Met Val Asn Asp Thr Val Ala 
        195                 200                 205             


Thr Met Ile Ser Cys Tyr Tyr Glu Asp His Gln Cys Glu Val Gly Met 
    210                 215                 220                 


Ile Val Gly Thr Gly Cys Asn Ala Cys Tyr Met Glu Glu Met Gln Asn 
225                 230                 235                 240 


Val Glu Leu Val Glu Gly Asp Glu Gly Arg Met Cys Val Asn Thr Glu 
                245                 250                 255     


Trp Gly Ala Phe Gly Asp Ser Gly Glu Leu Asp Glu Phe Leu Leu Glu 
            260                 265                 270         


Tyr Asp Arg Leu Val Asp Glu Ser Ser Ala Asn Pro Gly Gln Gln Leu 
        275                 280                 285             


Tyr Glu Lys Leu Ile Gly Gly Lys Tyr Met Gly Glu Leu Val Arg Leu 
    290                 295                 300                 


Val Leu Leu Arg Leu Val Asp Glu Asn Leu Leu Phe His Gly Glu Ala 
305                 310                 315                 320 


Ser Glu Gln Leu Arg Thr Arg Gly Ala Phe Glu Thr Arg Phe Val Ser 
                325                 330                 335     


Gln Val Glu Ser Asp Thr Gly Asp Arg Lys Gln Ile Tyr Asn Ile Leu 
            340                 345                 350         


Ser Thr Leu Gly Leu Arg Pro Ser Thr Thr Asp Cys Asp Ile Val Arg 
        355                 360                 365             


Arg Ala Cys Glu Ser Val Ser Thr Arg Ala Ala His Met Cys Ser Ala 
    370                 375                 380                 


Gly Leu Ala Gly Val Ile Asn Arg Met Arg Glu Ser Arg Ser Glu Asp 
385                 390                 395                 400 


Val Met Arg Ile Thr Val Gly Val Asp Gly Ser Val Tyr Lys Leu His 
                405                 410                 415     


Pro Ser Phe Lys Glu Arg Phe His Ala Ser Val Arg Arg Leu Thr Pro 
            420                 425                 430         


Ser Cys Glu Ile Thr Phe Ile Glu Ser Glu Glu Gly Ser Gly Arg Gly 
        435                 440                 445             


Ala Ala Leu Val Ser Ala Val Ala Cys Lys Lys Ala Cys Met Leu Gly 
    450                 455                 460                 


Gln 
465 


<210>  11
<211>  69
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  triple repeticin del pptido PTAP


<220>
<221>  CDS
<222>  (1)..(69)

<400>  11
gag cca gaa ccc aca gca ccg cct gag cct acc gcc cca ccc gaa ccg         48
Glu Pro Glu Pro Thr Ala Pro Pro Glu Pro Thr Ala Pro Pro Glu Pro           
1               5                   10                  15                

acg gcg cct cca gct gag taa                                             69
Thr Ala Pro Pro Ala Glu                                                   
            20                                                            


<210>  12
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  12

Glu Pro Glu Pro Thr Ala Pro Pro Glu Pro Thr Ala Pro Pro Glu Pro 
1               5                   10                  15      


Thr Ala Pro Pro Ala Glu 
            20          


<210>  13
<211>  8117
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Plsmido comercial pACT2

<400>  13
aggtggcact tttcggggaa atgtgcgcgg aacccctatt tgtttatttt tctaaataca       60

ttcaaatatg tatccgctca tgagacaata accctgataa atgcttcaat aatattgaaa      120

aaggaagagt atgagtattc aacatttccg tgtcgccctt attccctttt ttgcggcatt      180

ttgccttcct gtttttgctc acccagaaac gctggtgaaa gtaaaagatg ctgaagatca      240

gttgggtgca cgagtgggtt acatcgaact ggatctcaac agcggtaaga tccttgagag      300

ttttcgcccc gaagaacgtt ttccaatgat gagcactttt aaagttctgc tatgtggcgc      360

ggtattatcc cgtgttgacg ccgggcaaga gcaactcggt cgccgcatac actattctca      420

gaatgacttg gttgagtact caccagtcac agaaaagcat cttacggatg gcatgacagt      480

aagagaatta tgcagtgctg ccataaccat gagtgataac actgcggcca acttacttct      540

gacaacgatc ggaggaccga aggagctaac cgcttttttg cacaacatgg gggatcatgt      600

aactcgcctt gatcgttggg aaccggagct gaatgaagcc ataccaaacg acgagcgtga      660

caccacgatg cctgcagcaa tggcaacaac gttgcgcaaa ctattaactg gcgaactact      720

tactctagct tcccggcaac aattaataga ctggatggag gcggataaag ttgcaggacc      780

acttctgcgc tcggcccttc cggctggctg gtttattgct gataaatctg gagccggtga      840

gcgtgggtct cgcggtatca ttgcagcact ggggccagat ggtaagccct cccgtatcgt      900

agttatctac acgacgggga gtcaggcaac tatggatgaa cgaaatagac agatcgctga      960

gataggtgcc tcactgatta agcattggta actgtcagac caagtttact catatatact     1020

ttagattgat ttaaaacttc atttttaatt taaaaggatc taggtgaaga tcctttttga     1080

taatctcatg accaaaatcc cttaacgtga gttttcgttc cactgagcgt cagaccccgt     1140

agaaaagatc aaaggatctt cttgagatcc tttttttctg cgcgtaatct gctgcttgca     1200

aacaaaaaaa ccaccgctac cagcggtggt ttgtttgccg gatcaagagc taccaactct     1260

ttttccgaag gtaactggct tcagcagagc gcagatacca aatactgtcc ttctagtgta     1320

gccgtagtta ggccaccact tcaagaactc tgtagcaccg cctacatacc tcgctctgct     1380

aatcctgtta ccagtggctg ctgccagtgg cgataagtcg tgtcttaccg ggttggactc     1440

aagacgatag ttaccggata aggcgcagcg gtcgggctga acggggggtt cgtgcacaca     1500

gcccagcttg gagcgaacga cctacaccga actgagatac ctacagcgtg agctatgaga     1560

aagcgccacg cttcccgaag ggagaaaggc ggacaggtat ccggtaagcg gcagggtcgg     1620

aacaggagag cgcacgaggg agcttccagg gggaaacgcc tggtatcttt atagtcctgt     1680

cgggtttcgc cacctctgac ttgagcgtcg atttttgtga tgctcgtcag gggggcggag     1740

cctatggaaa aacgccagca acgcggcctt tttacggttc ctggcctttt gctggccttt     1800

tgctcacatg ttctttcctg cgttatcccc tgattctgtg gataaccgta ttaccgcctt     1860

tgagtgagct gataccgctc gccgcagccg aacgaccgag cgcagcgagt cagtgagcga     1920

ggaagcggaa gagcgcctga tgcggtattt tctccttacg catctgtgcg gtatttcaca     1980

ccgcatatgg tgcactctca gtacaatctg ctctgatgcc gcatagttaa gccagtatac     2040

actccgctat cgctacgtga ctgggtcatg gctgcgcccc gacacccgcc aacacccgct     2100

gacgcgccct gacgggcttg tctgctcccg gcatccgctt acagacaagc tgtgaccgtc     2160

tccgggagct gcatgtgtca gaggttttca ccgtcatcac cgaaacgcgc gaggcagcaa     2220

cttcttttct ttttttttct tttctctctc ccccgttgtt gtctcaccat atccgcaatg     2280

acaaaaaaaa tgatggaaga cactaaagga aaaaattaac gacaaagaca gcaccaacag     2340

atgtcgttgt tccagagctg atgaggggta tcttcgaaca cacgaaactt tttccttcct     2400

tcattcacgc acactactct ctaatgagca acggtatacg gccttccttc cagttacttg     2460

aatttgaaat aaaaaaagtt tgccgctttg ctatcaagta taaatagacc tgcaattatt     2520

aatcttttgt ttcctcgtca ttgttctcgt tccctttctt ccttgtttct ttttctgcac     2580

aatatttcaa gctataccaa gcatacaatc aactccaagc tttgcaaaga tggataaagc     2640

ggaattaatt cccgagcctc caaaaaagaa gagaaaggtc gaattgggta ccgccgccaa     2700

ttttaatcaa agtgggaata ttgctgatag ctcattgtcc ttcactttca ctaacagtag     2760

caacggtccg aacctcataa caactcaaac aaattctcaa gcgctttcac aaccaattgc     2820

ctcctctaac gttcatgata acttcatgaa taatgaaatc acggctagta aaattgatga     2880

tggtaataat tcaaaaccac tgtcacctgg ttggacggac caaactgcgt ataacgcgtt     2940

tggaatcact acagggatgt ttaataccac tacaatggat gatgtatata actatctatt     3000

cgatgatgaa gataccccac caaacccaaa aaaagagatc tgtatggctt acccatacga     3060

tgttccagat tacgctagct tgggtggtca tatggccatg gaggccccgg ggatccgaat     3120

tcgagctcga gagatctatg aatcgtagat actgaaaaac cccgcaagtt cacttcaact     3180

gtgcatcgtg caccatctca atttctttca tttatacatc gttttgcctt cttttatgta     3240

actatactcc tctaagtttc aatcttggcc atgtaacctc tgatctatag aattttttaa     3300

atgactagaa ttaatgccca tctttttttt ggacctaaat tcttcatgaa aatatattac     3360

gagggcttat tcagaagctt tggacttctt cgccagaggt ttggtcaagt ctccaatcaa     3420

ggttgtcggc ttgtctacct tgccagaaat ttacgaaaag atggaaaagg gtcaaatcgt     3480

tggtagatac gttgttgaca cttctaaata agcgaatttc ttatgattta tgatttttat     3540

tattaaataa gttataaaaa aaataagtgt atacaaattt taaagtgact cttaggtttt     3600

aaaacgaaaa ttcttgttct tgagtaactc tttcctgtag gtcaggttgc tttctcaggt     3660

atagcatgag gtcgctctta ttgaccacac ctctaccggc atgtgcgagg gacctaataa     3720

cttcgtatag catacattat acgaagttat attaagggtt ccggatcgcg gccgctcgac     3780

ctgcagccaa gctagcggac gtaaactcct cttcagacct aataacttcg tatagcatac     3840

attatacgaa gttatattaa gggttattga atatgatcgg aattggtcga gggacctaat     3900

aacttcgtat agcatacatt atacgaagtt atattaaggg ttccggatcg cggccgctcg     3960

acctgcagcc aggctagctt ggctggacgt aaactcctct tcagacctaa taacttcgat     4020

agcatacatt atacgaagtt atattaaggg ttattgatat gatcggaatt ggtcgactac     4080

gtcgttaagg ccgtttctga cagagtaaaa ttcttgaggg aactttcacc attatgggaa     4140

atggttcaag aaggtattga cttaaactcc atcaaatggt caggtcattg agtgtttttt     4200

atttgttgta tttttttttt tttagagaaa atcctccaat atcaaattag gaatcgtagt     4260

ttcatgattt tctgttacac ctaacttttt gtgtggtgcc ctcctccttg tcaatattaa     4320

tgttaaagtg caattctttt tccttatcac gttgagccat tagtatcaat ttgcttacct     4380

gtattccttt actatcctcc tttttctcct tcttgataaa tgtatgtaga ttgcgtatat     4440

agtttcgtct accctatgaa catattccat tttgtaattt cgtgtcgttt ctattatgaa     4500

tttcatttat aaagtttatg tacaaatatc ataaaaaaag agaatctttt taagcaagga     4560

ttttcttaac ttcttcggcg acagcatcac cgacttcggt ggtactgttg gaaccaccta     4620

aatcaccagt tctgatacct gcatccaaaa cctttttaac tgcatcttca atggccttac     4680

cttcttcagg caagttcaat gacaatttca acatcattgc agcagacaag atagtggcga     4740

tagggtcaac cttattcttt ggcaaatctg gagcagaacc gtggcatggt tcgtacaaac     4800

caaatgcggt gttcttgtct ggcaaagagg ccaaggacgc agatggcaac aaacccaagg     4860

aacctgggat aacggaggct tcatcggaga tgatatcacc aaacatgttg ctggtgatta     4920

taataccatt taggtgggtt gggttcttaa ctaggatcat ggcggcagaa tcaatcaatt     4980

gatgttgaac cttcaatgta ggaaattcgt tcttgatggt ttcctccaca gtttttctcc     5040

ataatcttga agaggccaaa acattagctt tatccaagga ccaaataggc aatggtggct     5100

catgttgtag ggccatgaaa gcggccattc ttgtgattct ttgcacttct ggaacggtgt     5160

attgttcact atcccaagcg acaccatcac catcgtcttc ctttctctta ccaaagtaaa     5220

tacctcccac taattctctg acaacaacga agtcagtacc tttagcaaat tgtggcttga     5280

ttggagataa gtctaaaaga gagtcggatg caaagttaca tggtcttaag ttggcgtaca     5340

attgaagttc tttacggatt tttagtaaac cttgttcagg tctaacacta ccggtacccc     5400

atttaggacc acccacagca cctaacaaaa cggcatcaac cttcttggag gcttccagcg     5460

cctcatctgg aagtgggaca cctgtagcat cgatagcagc accaccaatt aaatgatttt     5520

cgaaatcgaa cttgacattg gaacgaacat cagaaatagc tttaagaacc ttaatggctt     5580

cggctgtgat ttcttgacca acgtggtcac ctggcaaaac gacgatcttc ttaggggcag     5640

acataggggc agacattaga atggtatatc cttgaaatat atatatatat tgctgaaatg     5700

taaaaggtaa gaaaagttag aaagtaagac gattgctaac cacctattgg aaaaaacaat     5760

aggtccttaa ataatattgt caacttcaag tattgtgatg caagcattta gtcatgaacg     5820

cttctctatt ctatatgaaa agccggttcc ggcctctcac ctttcctttt tctcccaatt     5880

tttcagttga aaaaggtata tgcgtcaggc gacctctgaa attaacaaaa aatttccagt     5940

catcgaattt gattctgtgc gatagcgccc ctgtgtgttc tcgttatgtt gaggaaaaaa     6000

ataatggttg ctaagagatt cgaactcttg catcttacga tacctgagta ttcccacagt     6060

tccttaccac tcttttgtta ctctattgat ccagctcagc aaaggcagtg tgatctaaga     6120

ttctatcttc gcgatgtagt aaaactagct agaccgagaa agagactaga aatgcaaaag     6180

gcacttctac aatggctgcc atcattatta tccgatgtga cgctgcagct tctcaatgat     6240

attcgaatac gctttgagga gatacagcct aatatccgac aaactgtttt acagatttac     6300

gatcgtactt gttacccatc attgaatttt gaacatccga acctgggagt tttccctgaa     6360

acagatagta tatttgaacc tgtataataa tatatagtct agcgctttac ggaagacaat     6420

gtatgtattt cggttcctgg agaaactatt gcatctattg cataggtaat cttgcacgtc     6480

gcatccccgg ttcattttct gcgtttccat cttgcacttc aatagcatat ctttgttaac     6540

gaagcatctg tgcttcattt tgtagaacaa aaatgcaacg cgagagcgct aatttttcaa     6600

acaaagaatc tgagctgcat ttttacagaa cagaaatgca acgcgaaagc gctattttac     6660

caacgaagaa tctgtgcttc atttttgtaa aacaaaaatg caacgcgaga gcgctaattt     6720

ttcaaacaaa gaatctgagc tgcattttta cagaacagaa atgcaacgcg agagcgctat     6780

tttaccaaca aagaatctat acttcttttt tgttctacaa aaatgcatcc cgagagcgct     6840

atttttctaa caaagcatct tagattactt tttttctcct ttgtgcgctc tataatgcag     6900

tctcttgata actttttgca ctgtaggtcc gttaaggtta gaagaaggct actttggtgt     6960

ctattttctc ttccataaaa aaagcctgac tccacttccc gcgtttactg attactagcg     7020

aagctgcggg tgcatttttt caagataaag gcatccccga ttatattcta taccgatgtg     7080

gattgcgcat actttgtgaa cagaaagtga tagcgttgat gattcttcat tggtcagaaa     7140

attatgaacg gtttcttcta ttttgtctct atatactacg tataggaaat gtttacattt     7200

tcgtattgtt ttcgattcac tctatgaata gttcttacta caattttttt gtctaaagag     7260

taatactaga gataaacata aaaaatgtag aggtcgagtt tagatgcaag ttcaaggagc     7320

gaaaggtgga tgggtaggtt atatagggat atagcacaga gatatatagc aaagagatac     7380

ttttgagcaa tgtttgtgga agcggtattc gcaatatttt agtagctcgt tacagtccgg     7440

tgcgtttttg gttttttgaa agtgcgtctt cagagcgctt ttggttttca aaagcgctct     7500

gaagttccta tactttctag agaataggaa cttcggaata ggaacttcaa agcgtttccg     7560

aaaacgagcg cttccgaaaa tgcaacgcga gctgcgcaca tacagctcac tgttcacgtc     7620

gcacctatat ctgcgtgttg cctgtatata tatatacatg agaagaacgg catagtgcgt     7680

gtttatgctt aaatgcgtac ttatatgcgt ctatttatgt aggatgaaag gtagtctagt     7740

acctcctgtg atattatccc attccatgcg gggtatcgta tgcttccttc agcactaccc     7800

tttagctgtt ctatatgctg ccactcctca attggattag tctcatcctt caatgctatc     7860

atttcctttg atattggatc atatgcatag taccgagaaa ctagtgcgaa gtagtgatca     7920

ggtattgctg ttatctgatg agtatacgtt gtcctggcca cggcagaagc acgcttatcg     7980

ctccaatttc ccacaacatt agtcaactcc gttaggccct tcattgaaag aaatgaggtc     8040

atcaaatgtc ttccaatgtg agattttggg ccatttttta tagcaaagat tgaataaggc     8100

gcatttttct tcaaagc                                                    8117


<210>  14
<211>  9594
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Plsmido pACT2-GK-3xPTAP

<400>  14
aggtggcact tttcggggaa atgtgcgcgg aacccctatt tgtttatttt tctaaataca       60

ttcaaatatg tatccgctca tgagacaata accctgataa atgcttcaat aatattgaaa      120

aaggaagagt atgagtattc aacatttccg tgtcgccctt attccctttt ttgcggcatt      180

ttgccttcct gtttttgctc acccagaaac gctggtgaaa gtaaaagatg ctgaagatca      240

gttgggtgca cgagtgggtt acatcgaact ggatctcaac agcggtaaga tccttgagag      300

ttttcgcccc gaagaacgtt ttccaatgat gagcactttt aaagttctgc tatgtggcgc      360

ggtattatcc cgtgttgacg ccgggcaaga gcaactcggt cgccgcatac actattctca      420

gaatgacttg gttgagtact caccagtcac agaaaagcat cttacggatg gcatgacagt      480

aagagaatta tgcagtgctg ccataaccat gagtgataac actgcggcca acttacttct      540

gacaacgatc ggaggaccga aggagctaac cgcttttttg cacaacatgg gggatcatgt      600

aactcgcctt gatcgttggg aaccggagct gaatgaagcc ataccaaacg acgagcgtga      660

caccacgatg cctgcagcaa tggcaacaac gttgcgcaaa ctattaactg gcgaactact      720

tactctagct tcccggcaac aattaataga ctggatggag gcggataaag ttgcaggacc      780

acttctgcgc tcggcccttc cggctggctg gtttattgct gataaatctg gagccggtga      840

gcgtgggtct cgcggtatca ttgcagcact ggggccagat ggtaagccct cccgtatcgt      900

agttatctac acgacgggga gtcaggcaac tatggatgaa cgaaatagac agatcgctga      960

gataggtgcc tcactgatta agcattggta actgtcagac caagtttact catatatact     1020

ttagattgat ttaaaacttc atttttaatt taaaaggatc taggtgaaga tcctttttga     1080

taatctcatg accaaaatcc cttaacgtga gttttcgttc cactgagcgt cagaccccgt     1140

agaaaagatc aaaggatctt cttgagatcc tttttttctg cgcgtaatct gctgcttgca     1200

aacaaaaaaa ccaccgctac cagcggtggt ttgtttgccg gatcaagagc taccaactct     1260

ttttccgaag gtaactggct tcagcagagc gcagatacca aatactgtcc ttctagtgta     1320

gccgtagtta ggccaccact tcaagaactc tgtagcaccg cctacatacc tcgctctgct     1380

aatcctgtta ccagtggctg ctgccagtgg cgataagtcg tgtcttaccg ggttggactc     1440

aagacgatag ttaccggata aggcgcagcg gtcgggctga acggggggtt cgtgcacaca     1500

gcccagcttg gagcgaacga cctacaccga actgagatac ctacagcgtg agctatgaga     1560

aagcgccacg cttcccgaag ggagaaaggc ggacaggtat ccggtaagcg gcagggtcgg     1620

aacaggagag cgcacgaggg agcttccagg gggaaacgcc tggtatcttt atagtcctgt     1680

cgggtttcgc cacctctgac ttgagcgtcg atttttgtga tgctcgtcag gggggcggag     1740

cctatggaaa aacgccagca acgcggcctt tttacggttc ctggcctttt gctggccttt     1800

tgctcacatg ttctttcctg cgttatcccc tgattctgtg gataaccgta ttaccgcctt     1860

tgagtgagct gataccgctc gccgcagccg aacgaccgag cgcagcgagt cagtgagcga     1920

ggaagcggaa gagcgcctga tgcggtattt tctccttacg catctgtgcg gtatttcaca     1980

ccgcatatgg tgcactctca gtacaatctg ctctgatgcc gcatagttaa gccagtatac     2040

actccgctat cgctacgtga ctgggtcatg gctgcgcccc gacacccgcc aacacccgct     2100

gacgcgccct gacgggcttg tctgctcccg gcatccgctt acagacaagc tgtgaccgtc     2160

tccgggagct gcatgtgtca gaggttttca ccgtcatcac cgaaacgcgc gaggcagcaa     2220

cttcttttct ttttttttct tttctctctc ccccgttgtt gtctcaccat atccgcaatg     2280

acaaaaaaaa tgatggaaga cactaaagga aaaaattaac gacaaagaca gcaccaacag     2340

atgtcgttgt tccagagctg atgaggggta tcttcgaaca cacgaaactt tttccttcct     2400

tcattcacgc acactactct ctaatgagca acggtatacg gccttccttc cagttacttg     2460

aatttgaaat aaaaaaagtt tgccgctttg ctatcaagta taaatagacc tgcaattatt     2520

aatcttttgt ttcctcgtca ttgttctcgt tccctttctt ccttgtttct ttttctgcac     2580

aatatttcaa gctataccaa gcatacaatc aactccaagc tttgcaaaga tggataaagc     2640

ggaattaatt cccgagcctc caaaaaagaa gagaaaggtc gaattgggta ccgccgccaa     2700

ttttaatcaa agtgggaata ttgctgatag ctcattgtcc ttcactttca ctaacagtag     2760

caacggtccg aacctcataa caactcaaac aaattctcaa gcgctttcac aaccaattgc     2820

ctcctctaac gttcatgata acttcatgaa taatgaaatc acggctagta aaattgatga     2880

tggtaataat tcaaaaccac tgtcacctgg ttggacggac caaactgcgt ataacgcgtt     2940

tggaatcact acagggatgt ttaataccac tacaatggat gatgtatata actatctatt     3000

cgatgatgaa gataccccac caaacccaaa aaaagagatc tgtatggctt acccatacga     3060

tgttccagat tacgctagct tgggtggtca tatggccatg gaggccccgg ggatcctgat     3120

gctggacgac agagccagga tggaggccgc caagaaggag aaggtagagc agatcctggc     3180

agagttccag ctgcaggagg aggacctgaa gaaggtgatg agacggatgc agaaggagat     3240

ggaccgcggc ctgaggctgg agacccatga agaggccagt gtgaagatgc tgcccaccta     3300

cgtgcgctcc accccagaag gctcagaagt cggggacttc ctctccctgg acctgggtgg     3360

cactaacttc agggtgatgc tggtgaaggt gggagaaggt gaggaggggc agtggagcgt     3420

gaagaccaaa caccagatgt actccatccc cgaggacgcc atgaccggca ctgctgagat     3480

gctcttcgac tacatctctg agtgcatctc cgacttcctg gacaagcatc agatgaaaca     3540

caagaagctg cccctgggct tcaccttctc ctttcctgtg aggcacgaag acatcgataa     3600

gggcatcctt ctcaactgga ccaagggctt caaggcctca ggagcagaag ggaacaatgt     3660

cgtggggctt ctgcgagacg ctatcaaacg gagaggggac tttgaaatgg atgtggtggc     3720

aatggtgaat gacacggtgg ccacgatgat ctcctgctac tacgaagacc atcagtgcga     3780

ggtcggcatg atcgtgggca cgggctgcaa tgcctgctac atggaggaga tgcagaatgt     3840

ggagctggtg gagggggacg agggccgcat gtgcgtcaat accgagtggg gcgccttcgg     3900

ggactccggc gagctggacg agttcctgct ggagtatgac cgcctggtgg acgagagctc     3960

tgcaaacccc ggtcagcagc tgtatgagaa gctcataggt ggcaagtaca tgggcgagct     4020

ggtgcggctt gtgctgctca ggctcgtgga cgaaaacctg ctcttccacg gggaggcctc     4080

cgagcagctg cgcacacgcg gagccttcga gacgcgcttc gtgtcgcagg tggagagcga     4140

cacgggcgac cgcaagcaga tctacaacat cctgagcacg ctggggctgc gaccctcgac     4200

caccgactgc gacatcgtgc gccgcgcctg cgagagcgtg tctacgcgcg ctgcgcacat     4260

gtgctcggcg gggctggcgg gcgtcatcaa ccgcatgcgc gagagccgca gcgaggacgt     4320

aatgcgcatc actgtgggcg tggatggctc cgtgtacaag ctgcacccca gcttcaagga     4380

gcggttccat gccagcgtgc gcaggctgac gcccagctgc gagatcacct tcatcgagtc     4440

ggaggagggc agtggccggg gcgcggccct ggtctcggcg gtggcctgta agaaggcctg     4500

tatgctgggc cagtggatcc gaattcgagc tcgagagcca gaacccacag caccgcctga     4560

gcctaccgcc ccacccgaac cgacggcgcc tccagctgag taatcgagag atctatgaat     4620

cgtagatact gaaaaacccc gcaagttcac ttcaactgtg catcgtgcac catctcaatt     4680

tctttcattt atacatcgtt ttgccttctt ttatgtaact atactcctct aagtttcaat     4740

cttggccatg taacctctga tctatagaat tttttaaatg actagaatta atgcccatct     4800

tttttttgga cctaaattct tcatgaaaat atattacgag ggcttattca gaagctttgg     4860

acttcttcgc cagaggtttg gtcaagtctc caatcaaggt tgtcggcttg tctaccttgc     4920

cagaaattta cgaaaagatg gaaaagggtc aaatcgttgg tagatacgtt gttgacactt     4980

ctaaataagc gaatttctta tgatttatga tttttattat taaataagtt ataaaaaaaa     5040

taagtgtata caaattttaa agtgactctt aggttttaaa acgaaaattc ttgttcttga     5100

gtaactcttt cctgtaggtc aggttgcttt ctcaggtata gcatgaggtc gctcttattg     5160

accacacctc taccggcatg tgcgagggac ctaataactt cgtatagcat acattatacg     5220

aagttatatt aagggttccg gatcgcggcc gctcgacctg cagccaagct agcggacgta     5280

aactcctctt cagacctaat aacttcgtat agcatacatt atacgaagtt atattaaggg     5340

ttattgaata tgatcggaat tggtcgaggg acctaataac ttcgtatagc atacattata     5400

cgaagttata ttaagggttc cggatcgcgg ccgctcgacc tgcagccagg ctagcttggc     5460

tggacgtaaa ctcctcttca gacctaataa cttcgatagc atacattata cgaagttata     5520

ttaagggtta ttgatatgat cggaattggt cgactacgtc gttaaggccg tttctgacag     5580

agtaaaattc ttgagggaac tttcaccatt atgggaaatg gttcaagaag gtattgactt     5640

aaactccatc aaatggtcag gtcattgagt gttttttatt tgttgtattt tttttttttt     5700

agagaaaatc ctccaatatc aaattaggaa tcgtagtttc atgattttct gttacaccta     5760

actttttgtg tggtgccctc ctccttgtca atattaatgt taaagtgcaa ttctttttcc     5820

ttatcacgtt gagccattag tatcaatttg cttacctgta ttcctttact atcctccttt     5880

ttctccttct tgataaatgt atgtagattg cgtatatagt ttcgtctacc ctatgaacat     5940

attccatttt gtaatttcgt gtcgtttcta ttatgaattt catttataaa gtttatgtac     6000

aaatatcata aaaaaagaga atctttttaa gcaaggattt tcttaacttc ttcggcgaca     6060

gcatcaccga cttcggtggt actgttggaa ccacctaaat caccagttct gatacctgca     6120

tccaaaacct ttttaactgc atcttcaatg gccttacctt cttcaggcaa gttcaatgac     6180

aatttcaaca tcattgcagc agacaagata gtggcgatag ggtcaacctt attctttggc     6240

aaatctggag cagaaccgtg gcatggttcg tacaaaccaa atgcggtgtt cttgtctggc     6300

aaagaggcca aggacgcaga tggcaacaaa cccaaggaac ctgggataac ggaggcttca     6360

tcggagatga tatcaccaaa catgttgctg gtgattataa taccatttag gtgggttggg     6420

ttcttaacta ggatcatggc ggcagaatca atcaattgat gttgaacctt caatgtagga     6480

aattcgttct tgatggtttc ctccacagtt tttctccata atcttgaaga ggccaaaaca     6540

ttagctttat ccaaggacca aataggcaat ggtggctcat gttgtagggc catgaaagcg     6600

gccattcttg tgattctttg cacttctgga acggtgtatt gttcactatc ccaagcgaca     6660

ccatcaccat cgtcttcctt tctcttacca aagtaaatac ctcccactaa ttctctgaca     6720

acaacgaagt cagtaccttt agcaaattgt ggcttgattg gagataagtc taaaagagag     6780

tcggatgcaa agttacatgg tcttaagttg gcgtacaatt gaagttcttt acggattttt     6840

agtaaacctt gttcaggtct aacactaccg gtaccccatt taggaccacc cacagcacct     6900

aacaaaacgg catcaacctt cttggaggct tccagcgcct catctggaag tgggacacct     6960

gtagcatcga tagcagcacc accaattaaa tgattttcga aatcgaactt gacattggaa     7020

cgaacatcag aaatagcttt aagaacctta atggcttcgg ctgtgatttc ttgaccaacg     7080

tggtcacctg gcaaaacgac gatcttctta ggggcagaca taggggcaga cattagaatg     7140

gtatatcctt gaaatatata tatatattgc tgaaatgtaa aaggtaagaa aagttagaaa     7200

gtaagacgat tgctaaccac ctattggaaa aaacaatagg tccttaaata atattgtcaa     7260

cttcaagtat tgtgatgcaa gcatttagtc atgaacgctt ctctattcta tatgaaaagc     7320

cggttccggc ctctcacctt tcctttttct cccaattttt cagttgaaaa aggtatatgc     7380

gtcaggcgac ctctgaaatt aacaaaaaat ttccagtcat cgaatttgat tctgtgcgat     7440

agcgcccctg tgtgttctcg ttatgttgag gaaaaaaata atggttgcta agagattcga     7500

actcttgcat cttacgatac ctgagtattc ccacagttcc ttaccactct tttgttactc     7560

tattgatcca gctcagcaaa ggcagtgtga tctaagattc tatcttcgcg atgtagtaaa     7620

actagctaga ccgagaaaga gactagaaat gcaaaaggca cttctacaat ggctgccatc     7680

attattatcc gatgtgacgc tgcagcttct caatgatatt cgaatacgct ttgaggagat     7740

acagcctaat atccgacaaa ctgttttaca gatttacgat cgtacttgtt acccatcatt     7800

gaattttgaa catccgaacc tgggagtttt ccctgaaaca gatagtatat ttgaacctgt     7860

ataataatat atagtctagc gctttacgga agacaatgta tgtatttcgg ttcctggaga     7920

aactattgca tctattgcat aggtaatctt gcacgtcgca tccccggttc attttctgcg     7980

tttccatctt gcacttcaat agcatatctt tgttaacgaa gcatctgtgc ttcattttgt     8040

agaacaaaaa tgcaacgcga gagcgctaat ttttcaaaca aagaatctga gctgcatttt     8100

tacagaacag aaatgcaacg cgaaagcgct attttaccaa cgaagaatct gtgcttcatt     8160

tttgtaaaac aaaaatgcaa cgcgagagcg ctaatttttc aaacaaagaa tctgagctgc     8220

atttttacag aacagaaatg caacgcgaga gcgctatttt accaacaaag aatctatact     8280

tcttttttgt tctacaaaaa tgcatcccga gagcgctatt tttctaacaa agcatcttag     8340

attacttttt ttctcctttg tgcgctctat aatgcagtct cttgataact ttttgcactg     8400

taggtccgtt aaggttagaa gaaggctact ttggtgtcta ttttctcttc cataaaaaaa     8460

gcctgactcc acttcccgcg tttactgatt actagcgaag ctgcgggtgc attttttcaa     8520

gataaaggca tccccgatta tattctatac cgatgtggat tgcgcatact ttgtgaacag     8580

aaagtgatag cgttgatgat tcttcattgg tcagaaaatt atgaacggtt tcttctattt     8640

tgtctctata tactacgtat aggaaatgtt tacattttcg tattgttttc gattcactct     8700

atgaatagtt cttactacaa tttttttgtc taaagagtaa tactagagat aaacataaaa     8760

aatgtagagg tcgagtttag atgcaagttc aaggagcgaa aggtggatgg gtaggttata     8820

tagggatata gcacagagat atatagcaaa gagatacttt tgagcaatgt ttgtggaagc     8880

ggtattcgca atattttagt agctcgttac agtccggtgc gtttttggtt ttttgaaagt     8940

gcgtcttcag agcgcttttg gttttcaaaa gcgctctgaa gttcctatac tttctagaga     9000

ataggaactt cggaatagga acttcaaagc gtttccgaaa acgagcgctt ccgaaaatgc     9060

aacgcgagct gcgcacatac agctcactgt tcacgtcgca cctatatctg cgtgttgcct     9120

gtatatatat atacatgaga agaacggcat agtgcgtgtt tatgcttaaa tgcgtactta     9180

tatgcgtcta tttatgtagg atgaaaggta gtctagtacc tcctgtgata ttatcccatt     9240

ccatgcgggg tatcgtatgc ttccttcagc actacccttt agctgttcta tatgctgcca     9300

ctcctcaatt ggattagtct catccttcaa tgctatcatt tcctttgata ttggatcata     9360

tgcatagtac cgagaaacta gtgcgaagta gtgatcaggt attgctgtta tctgatgagt     9420

atacgttgtc ctggccacgg cagaagcacg cttatcgctc caatttccca caacattagt     9480

caactccgtt aggcccttca ttgaaagaaa tgaggtcatc aaatgtcttc caatgtgaga     9540

ttttgggcca ttttttatag caaagattga ataaggcgca tttttcttca aagc           9594


<210>  15
<211>  342
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Dominio de activacin transcripcional de Gal4 (GAD-Gal4 Activating
       Domain)

<400>  15
gccaatttta atcaaagtgg gaatattgct gatagctcat tgtccttcac tttcactaac       60

agtagcaacg gtccgaacct cataacaact caaacaaatt ctcaagcgct ttcacaacca      120

attgcctcct ctaacgttca tgataacttc atgaataatg aaatcacggc tagtaaaatt      180

gatgatggta ataattcaaa accactgtca cctggttgga cggaccaaac tgcgtataac      240

gcgtttggaa tcactacagg gatgtttaat accactacaa tggatgatgt atataactat      300

ctattcgatg atgaagatac cccaccaaac ccaaaaaaag ag                         342


<210>  16
<211>  398
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  promotor de ADH1 en el plsmido pACT2

<400>  16
gcaacttctt ttcttttttt ttcttttctc tctcccccgt tgttgtctca ccatatccgc       60

aatgacaaaa aaaatgatgg aagacactaa aggaaaaaat taacgacaaa gacagcacca      120

acagatgtcg ttgttccaga gctgatgagg ggtatcttcg aacacacgaa actttttcct      180

tccttcattc acgcacacta ctctctaatg agcaacggta tacggccttc cttccagtta      240

cttgaatttg aaataaaaaa agtttgccgc tttgctatca agtataaata gacctgcaat      300

tattaatctt ttgtttcctc gtcattgttc tcgttccctt tcttccttgt ttctttttct      360

gcacaatatt tcaagctata ccaagcatac aatcaact                              398


<210>  17
<211>  73
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucletido OV570

<400>  17
tcgagagcca gaacccacag caccgcctga gcctaccgcc ccacccgaac cgacggcgcc       60

tccagctgag taa                                                          73


<210>  18
<211>  73
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucletido OV571

<400>  18
tcgattactc agctggaggc gccgtcggtt cgggtggggc ggtaggctca ggcggtgctg       60

tgggttctgg ctc                                                          73


<210>  19
<211>  8190
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Plsmido pACT2-3xPTAP

<400>  19
aggtggcact tttcggggaa atgtgcgcgg aacccctatt tgtttatttt tctaaataca       60

ttcaaatatg tatccgctca tgagacaata accctgataa atgcttcaat aatattgaaa      120

aaggaagagt atgagtattc aacatttccg tgtcgccctt attccctttt ttgcggcatt      180

ttgccttcct gtttttgctc acccagaaac gctggtgaaa gtaaaagatg ctgaagatca      240

gttgggtgca cgagtgggtt acatcgaact ggatctcaac agcggtaaga tccttgagag      300

ttttcgcccc gaagaacgtt ttccaatgat gagcactttt aaagttctgc tatgtggcgc      360

ggtattatcc cgtgttgacg ccgggcaaga gcaactcggt cgccgcatac actattctca      420

gaatgacttg gttgagtact caccagtcac agaaaagcat cttacggatg gcatgacagt      480

aagagaatta tgcagtgctg ccataaccat gagtgataac actgcggcca acttacttct      540

gacaacgatc ggaggaccga aggagctaac cgcttttttg cacaacatgg gggatcatgt      600

aactcgcctt gatcgttggg aaccggagct gaatgaagcc ataccaaacg acgagcgtga      660

caccacgatg cctgcagcaa tggcaacaac gttgcgcaaa ctattaactg gcgaactact      720

tactctagct tcccggcaac aattaataga ctggatggag gcggataaag ttgcaggacc      780

acttctgcgc tcggcccttc cggctggctg gtttattgct gataaatctg gagccggtga      840

gcgtgggtct cgcggtatca ttgcagcact ggggccagat ggtaagccct cccgtatcgt      900

agttatctac acgacgggga gtcaggcaac tatggatgaa cgaaatagac agatcgctga      960

gataggtgcc tcactgatta agcattggta actgtcagac caagtttact catatatact     1020

ttagattgat ttaaaacttc atttttaatt taaaaggatc taggtgaaga tcctttttga     1080

taatctcatg accaaaatcc cttaacgtga gttttcgttc cactgagcgt cagaccccgt     1140

agaaaagatc aaaggatctt cttgagatcc tttttttctg cgcgtaatct gctgcttgca     1200

aacaaaaaaa ccaccgctac cagcggtggt ttgtttgccg gatcaagagc taccaactct     1260

ttttccgaag gtaactggct tcagcagagc gcagatacca aatactgtcc ttctagtgta     1320

gccgtagtta ggccaccact tcaagaactc tgtagcaccg cctacatacc tcgctctgct     1380

aatcctgtta ccagtggctg ctgccagtgg cgataagtcg tgtcttaccg ggttggactc     1440

aagacgatag ttaccggata aggcgcagcg gtcgggctga acggggggtt cgtgcacaca     1500

gcccagcttg gagcgaacga cctacaccga actgagatac ctacagcgtg agctatgaga     1560

aagcgccacg cttcccgaag ggagaaaggc ggacaggtat ccggtaagcg gcagggtcgg     1620

aacaggagag cgcacgaggg agcttccagg gggaaacgcc tggtatcttt atagtcctgt     1680

cgggtttcgc cacctctgac ttgagcgtcg atttttgtga tgctcgtcag gggggcggag     1740

cctatggaaa aacgccagca acgcggcctt tttacggttc ctggcctttt gctggccttt     1800

tgctcacatg ttctttcctg cgttatcccc tgattctgtg gataaccgta ttaccgcctt     1860

tgagtgagct gataccgctc gccgcagccg aacgaccgag cgcagcgagt cagtgagcga     1920

ggaagcggaa gagcgcctga tgcggtattt tctccttacg catctgtgcg gtatttcaca     1980

ccgcatatgg tgcactctca gtacaatctg ctctgatgcc gcatagttaa gccagtatac     2040

actccgctat cgctacgtga ctgggtcatg gctgcgcccc gacacccgcc aacacccgct     2100

gacgcgccct gacgggcttg tctgctcccg gcatccgctt acagacaagc tgtgaccgtc     2160

tccgggagct gcatgtgtca gaggttttca ccgtcatcac cgaaacgcgc gaggcagcaa     2220

cttcttttct ttttttttct tttctctctc ccccgttgtt gtctcaccat atccgcaatg     2280

acaaaaaaaa tgatggaaga cactaaagga aaaaattaac gacaaagaca gcaccaacag     2340

atgtcgttgt tccagagctg atgaggggta tcttcgaaca cacgaaactt tttccttcct     2400

tcattcacgc acactactct ctaatgagca acggtatacg gccttccttc cagttacttg     2460

aatttgaaat aaaaaaagtt tgccgctttg ctatcaagta taaatagacc tgcaattatt     2520

aatcttttgt ttcctcgtca ttgttctcgt tccctttctt ccttgtttct ttttctgcac     2580

aatatttcaa gctataccaa gcatacaatc aactccaagc tttgcaaaga tggataaagc     2640

ggaattaatt cccgagcctc caaaaaagaa gagaaaggtc gaattgggta ccgccgccaa     2700

ttttaatcaa agtgggaata ttgctgatag ctcattgtcc ttcactttca ctaacagtag     2760

caacggtccg aacctcataa caactcaaac aaattctcaa gcgctttcac aaccaattgc     2820

ctcctctaac gttcatgata acttcatgaa taatgaaatc acggctagta aaattgatga     2880

tggtaataat tcaaaaccac tgtcacctgg ttggacggac caaactgcgt ataacgcgtt     2940

tggaatcact acagggatgt ttaataccac tacaatggat gatgtatata actatctatt     3000

cgatgatgaa gataccccac caaacccaaa aaaagagatc tgtatggctt acccatacga     3060

tgttccagat tacgctagct tgggtggtca tatggccatg gaggccccgg ggatccgaat     3120

tcgagctcga gagccagaac ccacagcacc gcctgagcct accgccccac ccgaaccgac     3180

ggcgcctcca gctgagtaat cgagagatct atgaatcgta gatactgaaa aaccccgcaa     3240

gttcacttca actgtgcatc gtgcaccatc tcaatttctt tcatttatac atcgttttgc     3300

cttcttttat gtaactatac tcctctaagt ttcaatcttg gccatgtaac ctctgatcta     3360

tagaattttt taaatgacta gaattaatgc ccatcttttt tttggaccta aattcttcat     3420

gaaaatatat tacgagggct tattcagaag ctttggactt cttcgccaga ggtttggtca     3480

agtctccaat caaggttgtc ggcttgtcta ccttgccaga aatttacgaa aagatggaaa     3540

agggtcaaat cgttggtaga tacgttgttg acacttctaa ataagcgaat ttcttatgat     3600

ttatgatttt tattattaaa taagttataa aaaaaataag tgtatacaaa ttttaaagtg     3660

actcttaggt tttaaaacga aaattcttgt tcttgagtaa ctctttcctg taggtcaggt     3720

tgctttctca ggtatagcat gaggtcgctc ttattgacca cacctctacc ggcatgtgcg     3780

agggacctaa taacttcgta tagcatacat tatacgaagt tatattaagg gttccggatc     3840

gcggccgctc gacctgcagc caagctagcg gacgtaaact cctcttcaga cctaataact     3900

tcgtatagca tacattatac gaagttatat taagggttat tgaatatgat cggaattggt     3960

cgagggacct aataacttcg tatagcatac attatacgaa gttatattaa gggttccgga     4020

tcgcggccgc tcgacctgca gccaggctag cttggctgga cgtaaactcc tcttcagacc     4080

taataacttc gatagcatac attatacgaa gttatattaa gggttattga tatgatcgga     4140

attggtcgac tacgtcgtta aggccgtttc tgacagagta aaattcttga gggaactttc     4200

accattatgg gaaatggttc aagaaggtat tgacttaaac tccatcaaat ggtcaggtca     4260

ttgagtgttt tttatttgtt gtattttttt ttttttagag aaaatcctcc aatatcaaat     4320

taggaatcgt agtttcatga ttttctgtta cacctaactt tttgtgtggt gccctcctcc     4380

ttgtcaatat taatgttaaa gtgcaattct ttttccttat cacgttgagc cattagtatc     4440

aatttgctta cctgtattcc tttactatcc tcctttttct ccttcttgat aaatgtatgt     4500

agattgcgta tatagtttcg tctaccctat gaacatattc cattttgtaa tttcgtgtcg     4560

tttctattat gaatttcatt tataaagttt atgtacaaat atcataaaaa aagagaatct     4620

ttttaagcaa ggattttctt aacttcttcg gcgacagcat caccgacttc ggtggtactg     4680

ttggaaccac ctaaatcacc agttctgata cctgcatcca aaaccttttt aactgcatct     4740

tcaatggcct taccttcttc aggcaagttc aatgacaatt tcaacatcat tgcagcagac     4800

aagatagtgg cgatagggtc aaccttattc tttggcaaat ctggagcaga accgtggcat     4860

ggttcgtaca aaccaaatgc ggtgttcttg tctggcaaag aggccaagga cgcagatggc     4920

aacaaaccca aggaacctgg gataacggag gcttcatcgg agatgatatc accaaacatg     4980

ttgctggtga ttataatacc atttaggtgg gttgggttct taactaggat catggcggca     5040

gaatcaatca attgatgttg aaccttcaat gtaggaaatt cgttcttgat ggtttcctcc     5100

acagtttttc tccataatct tgaagaggcc aaaacattag ctttatccaa ggaccaaata     5160

ggcaatggtg gctcatgttg tagggccatg aaagcggcca ttcttgtgat tctttgcact     5220

tctggaacgg tgtattgttc actatcccaa gcgacaccat caccatcgtc ttcctttctc     5280

ttaccaaagt aaatacctcc cactaattct ctgacaacaa cgaagtcagt acctttagca     5340

aattgtggct tgattggaga taagtctaaa agagagtcgg atgcaaagtt acatggtctt     5400

aagttggcgt acaattgaag ttctttacgg atttttagta aaccttgttc aggtctaaca     5460

ctaccggtac cccatttagg accacccaca gcacctaaca aaacggcatc aaccttcttg     5520

gaggcttcca gcgcctcatc tggaagtggg acacctgtag catcgatagc agcaccacca     5580

attaaatgat tttcgaaatc gaacttgaca ttggaacgaa catcagaaat agctttaaga     5640

accttaatgg cttcggctgt gatttcttga ccaacgtggt cacctggcaa aacgacgatc     5700

ttcttagggg cagacatagg ggcagacatt agaatggtat atccttgaaa tatatatata     5760

tattgctgaa atgtaaaagg taagaaaagt tagaaagtaa gacgattgct aaccacctat     5820

tggaaaaaac aataggtcct taaataatat tgtcaacttc aagtattgtg atgcaagcat     5880

ttagtcatga acgcttctct attctatatg aaaagccggt tccggcctct cacctttcct     5940

ttttctccca atttttcagt tgaaaaaggt atatgcgtca ggcgacctct gaaattaaca     6000

aaaaatttcc agtcatcgaa tttgattctg tgcgatagcg cccctgtgtg ttctcgttat     6060

gttgaggaaa aaaataatgg ttgctaagag attcgaactc ttgcatctta cgatacctga     6120

gtattcccac agttccttac cactcttttg ttactctatt gatccagctc agcaaaggca     6180

gtgtgatcta agattctatc ttcgcgatgt agtaaaacta gctagaccga gaaagagact     6240

agaaatgcaa aaggcacttc tacaatggct gccatcatta ttatccgatg tgacgctgca     6300

gcttctcaat gatattcgaa tacgctttga ggagatacag cctaatatcc gacaaactgt     6360

tttacagatt tacgatcgta cttgttaccc atcattgaat tttgaacatc cgaacctggg     6420

agttttccct gaaacagata gtatatttga acctgtataa taatatatag tctagcgctt     6480

tacggaagac aatgtatgta tttcggttcc tggagaaact attgcatcta ttgcataggt     6540

aatcttgcac gtcgcatccc cggttcattt tctgcgtttc catcttgcac ttcaatagca     6600

tatctttgtt aacgaagcat ctgtgcttca ttttgtagaa caaaaatgca acgcgagagc     6660

gctaattttt caaacaaaga atctgagctg catttttaca gaacagaaat gcaacgcgaa     6720

agcgctattt taccaacgaa gaatctgtgc ttcatttttg taaaacaaaa atgcaacgcg     6780

agagcgctaa tttttcaaac aaagaatctg agctgcattt ttacagaaca gaaatgcaac     6840

gcgagagcgc tattttacca acaaagaatc tatacttctt ttttgttcta caaaaatgca     6900

tcccgagagc gctatttttc taacaaagca tcttagatta ctttttttct cctttgtgcg     6960

ctctataatg cagtctcttg ataacttttt gcactgtagg tccgttaagg ttagaagaag     7020

gctactttgg tgtctatttt ctcttccata aaaaaagcct gactccactt cccgcgttta     7080

ctgattacta gcgaagctgc gggtgcattt tttcaagata aaggcatccc cgattatatt     7140

ctataccgat gtggattgcg catactttgt gaacagaaag tgatagcgtt gatgattctt     7200

cattggtcag aaaattatga acggtttctt ctattttgtc tctatatact acgtatagga     7260

aatgtttaca ttttcgtatt gttttcgatt cactctatga atagttctta ctacaatttt     7320

tttgtctaaa gagtaatact agagataaac ataaaaaatg tagaggtcga gtttagatgc     7380

aagttcaagg agcgaaaggt ggatgggtag gttatatagg gatatagcac agagatatat     7440

agcaaagaga tacttttgag caatgtttgt ggaagcggta ttcgcaatat tttagtagct     7500

cgttacagtc cggtgcgttt ttggtttttt gaaagtgcgt cttcagagcg cttttggttt     7560

tcaaaagcgc tctgaagttc ctatactttc tagagaatag gaacttcgga ataggaactt     7620

caaagcgttt ccgaaaacga gcgcttccga aaatgcaacg cgagctgcgc acatacagct     7680

cactgttcac gtcgcaccta tatctgcgtg ttgcctgtat atatatatac atgagaagaa     7740

cggcatagtg cgtgtttatg cttaaatgcg tacttatatg cgtctattta tgtaggatga     7800

aaggtagtct agtacctcct gtgatattat cccattccat gcggggtatc gtatgcttcc     7860

ttcagcacta ccctttagct gttctatatg ctgccactcc tcaattggat tagtctcatc     7920

cttcaatgct atcatttcct ttgatattgg atcatatgca tagtaccgag aaactagtgc     7980

gaagtagtga tcaggtattg ctgttatctg atgagtatac gttgtcctgg ccacggcaga     8040

agcacgctta tcgctccaat ttcccacaac attagtcaac tccgttaggc ccttcattga     8100

aagaaatgag gtcatcaaat gtcttccaat gtgagatttt gggccatttt ttatagcaaa     8160

gattgaataa ggcgcatttt tcttcaaagc                                      8190


<210>  20
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Cebador OV500

<400>  20
gggatcctga tgctggacga cagagccagg                                        30


<210>  21
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Cebador OV562

<400>  21
gggatccact ggcccagcat acaggccttc                                        30


<210>  22
<211>  7001
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Plsmido pRS402-LexA

<400>  22
tcgcgcgttt cggtgatgac ggtgaaaacc tctgacacat gcagctcccg gagacggtca       60

cagcttgtct gtaagcggat gccgggagca gacaagcccg tcagggcgcg tcagcgggtg      120

ttggcgggtg tcggggctgg cttaactatg cggcatcaga gcagattgta ctgagagtgc      180

accatagatc tgaattaatt cttgaataat acataacttt tcttaaaaga atcaaagaca      240

gataaaattt aagagatatt aaatattagt gagaagccga gaattttgta acaccaacat      300

aacactgaca tctttaacaa cttttaatta tgatacattt cttacgtcat gattgattat      360

tacagctatg ctgacaaatg actcttgttg catggctacg aaccgggtaa tactaagtga      420

ttgactcttg ctgacctttt attaagaact aaatggacaa tattatggag catttcatgt      480

ataaattggt gcgtaaaatc gttggatctc tcttctaagt acatcctact ataacaatca      540

agaaaaacaa gaaaatcgga caaaacaatc aagtatggat tctagaacag ttggtatatt      600

aggaggggga caattgggac gtatgattgt tgaggcagca aacaggctca acattaagac      660

ggtaatacta gatgctgaaa attctcctgc caaacaaata agcaactcca atgaccacgt      720

taatggctcc ttttccaatc ctcttgatat cgaaaaacta gctgaaaaat gtgatgtgct      780

aacgattgag attgagcatg ttgatgttcc tacactaaag aatcttcaag taaaacatcc      840

caaattaaaa atttaccctt ctccagaaac aatcagattg atacaagaca aatatattca      900

aaaagagcat ttaatcaaaa atggtatagc agttacccaa agtgttcctg tggaacaagc      960

cagtgagacg tccctattga atgttggaag agatttgggt tttccattcg tcttgaagtc     1020

gaggactttg gcatacgatg gaagaggtaa cttcgttgta aagaataagg aaatgattcc     1080

ggaagctttg gaagtactga aggatcgtcc tttgtacgcc gaaaaatggg caccatttac     1140

taaagaatta gcagtcatga ttgtgaggtc tgttaacggt ttagtgtttt cttacccaat     1200

tgtagagact atccacaagg acaatatttg tgacttatgt tatgcgcctg ctagagttcc     1260

ggactccgtt caacttaagg cgaagttgtt ggcagaaaat gcaatcaaat cttttcccgg     1320

ttgtggtata tttggtgtgg aaatgttcta tttagaaaca ggggaattgc ttattaacga     1380

aattgcccca aggcctcaca actctggaca ttataccatt gatgcttgcg tcacttctca     1440

atttgaagct catttgagat caatattgga tttgccaatg ccaaagaatt tcacatcttt     1500

ctccaccatt acaacgaacg ccattatgct aaatgttctt ggagacaaac atacaaaaga     1560

taaagagcta gaaacttgcg aaagagcatt ggcgactcca ggttcctcag tgtacttata     1620

tggaaaagag tctagaccta acagaaaagt aggtcacata aatattattg cctccagtat     1680

ggcggaatgt gaacaaaggc tgaactacat tacaggtaga actgatattc caatcaaaat     1740

ctctgtcgct caaaagttgg acttggaagc aatggtcaaa ccattggttg gaatcatcat     1800

gggatcagac tctgacttgc cggtaatgtc tgccgcatgt gcggttttaa aagattttgg     1860

cgttccattt gaagtgacaa tagtctctgc tcatagaact ccacatagga tgtcagcata     1920

tgctatttcc gcaagcaagc gtggaattaa aacaattatc gctggagctg gtggggctgc     1980

tcacttgcca ggtatggtgg ctgcaatgac accacttcct gtcatcggtg tgcccgtaaa     2040

aggttcttgt ctagatggag tagattcttt acattcaatt gtgcaaatgc ctagaggtgt     2100

tccagtagct accgtcgcta ttaataatag tacgaacgct gcgctgttgg ctgtcagact     2160

gcttggcgct tatgattcaa gttatacaac gaaaatggaa cagtttttat taaagcaaga     2220

agaagaagtt cttgtcaaag cacaaaagtt agaaactgtc ggttacgaag cttatctaga     2280

aaacaagtaa tatataagtt tattgatata cttgtacagc aaataattat aaaatgatat     2340

acctattttt taggctttgt tatgattaca tcaaatgtgg acttcataca tagaaatcaa     2400

cgcttacagg tgtccttttt taagaatttc atacataaga tctatgcggt gtgaaatacc     2460

gcacagatgc gtaaggagaa aataccgcat caggaaattg taaacgttaa tattttgtta     2520

aaattcgcgt taaatttttg ttaaatcagc tcatttttta accaataggc cgaaatcggc     2580

aaaatccctt ataaatcaaa agaatagacc gagatagggt tgagtgttgt tccagtttgg     2640

aacaagagtc cactattaaa gaacgtggac tccaacgtca aagggcgaaa aaccgtctat     2700

cagggcgatg gcccactacg tgaaccatca ccctaatcaa gttttttggg gtcgaggtgc     2760

cgtaaagcac taaatcggaa ccctaaaggg agcccccgat ttagagcttg acggggaaag     2820

ccggcgaacg tggcgagaaa ggaagggaag aaagcgaaag gagcgggcgc tagggcgctg     2880

gcaagtgtag cggtcacgct gcgcgtaacc accacacccg ccgcgcttaa tgcgccgcta     2940

cagggcgcgt cgcgccattc gccattcagg ctgcgcaact gttgggaagg gcgatcggtg     3000

cgggcctctt cgctattacg ccagctggcg aaagggggat gtgctgcaag gcgattaagt     3060

tgggtaacgc cagggttttc ccagtcacga cgttgtaaaa cgacggccag tgagcgcgcg     3120

taatacgact cactataggg cgaattgggt accttttgtt gtttccgggt gtacaatatg     3180

gacttcctct tttctggcaa ccaaacccat acatcgggat tcctataata ccttcgttgg     3240

tctccctaac atgtaggtgg cggaggggag atatacaata gaacagatac cagacaagac     3300

ataatgggct aaacaagact acaccaatta cactgcctca ttgatggtgg tacataacga     3360

actaatactg tagccctaga cttgatagcc atcatcatat cgaagtttca ctaccctttt     3420

tccatttgcc atctattgaa gtaataatag gcgcatgcaa cttcttttct ttttttttct     3480

tttctctctc ccccgttgtt gtctcaccat atccgcaatg acaaaaaaaa tgatggaaga     3540

cactaaagga aaaaattaac gacaaagaca gcaccaacag atgtcgttgt tccagagctg     3600

atgaggggta tcttcgaaca cacgaaactt tttccttcct tcattcacgc acactactct     3660

ctaatgagca acggtatacg gccttccttc cagttacttg aatttgaaat aaaaaaagtt     3720

tgccgctttg ctatcaagta taaatagacc tgcaattatt aatcttttgt ttcctcgtca     3780

ttgttctcgt tccctttctt ccttgtttct ttttctgcac aatatttcaa gctataccaa     3840

gcatacaatc aactccaagc ttgaattaat tccgggcgga atgaaagcgt taacggccag     3900

gcaacaagag gtgtttgatc tcatccgtga tcacatcagc cagacaggta tgccgccgac     3960

gcgtgcggaa atcgcgcagc gtttggggtt ccgttcccca aacgcggctg aagaacatct     4020

gaaggcgctg gcacgcaaag gcgttattga aattgtttcc ggcgcatcac gcgggattcg     4080

tctgttgcag gaagaggaag aagggttgcc gctggtaggt cgtgtggctg ccggtgaacc     4140

acttctggcg caacagcata ttgaaggtca ttatcaggtc gatccttcct tattcaagcc     4200

gaatgctgat ttcctgctgc gcgtcagcgg gatgtcgatg aaagatatcg gcattatgga     4260

tggtgacttg ctggcagtgc ataaaactca ggatgtacgt aacggtcagg tcgttgtcgc     4320

acgtattgat gacgaagtta ccgttaagcg cctgaaaaaa cagggcaata aagtcgaact     4380

gttgccagaa aatagcgagt ttaaaccaat tgtcgtagat cttcgtcagc agagcttcac     4440

cattgaaggg ctggcggttg gggttattcg caacggcgac tggctggaat tcccggggat     4500

ccgtcgacct gcagccaagc taattccggg cgaatttctt atgatttatg atttttatta     4560

ttaaataagt tataaaaaaa ataagtgtat acaaatttta aagtgactct taggttttaa     4620

aacgaaaatt cttgttcttg agtaactctt tcctgtaggt caggttgctt tctcaggtat     4680

agcatgaggt cgctcttatt gaccacacct ctaccggcat gcgagctcca gcttttgttc     4740

cctttagtga gggttaattg cgcgcttggc gtaatcatgg tcatagctgt ttcctgtgtg     4800

aaattgttat ccgctcacaa ttccacacaa catacgagcc ggaagcataa agtgtaaagc     4860

ctggggtgcc taatgagtga gctaactcac attaattgcg ttgcgctcac tgcccgcttt     4920

ccagtcggga aacctgtcgt gccagctgca ttaatgaatc ggccaacgcg cggggagagg     4980

cggtttgcgt attgggcgct cttccgcttc ctcgctcact gactcgctgc gctcggtcgt     5040

tcggctgcgg cgagcggtat cagctcactc aaaggcggta atacggttat ccacagaatc     5100

aggggataac gcaggaaaga acatgtgagc aaaaggccag caaaaggcca ggaaccgtaa     5160

aaaggccgcg ttgctggcgt ttttccatag gctccgcccc cctgacgagc atcacaaaaa     5220

tcgacgctca agtcagaggt ggcgaaaccc gacaggacta taaagatacc aggcgtttcc     5280

ccctggaagc tccctcgtgc gctctcctgt tccgaccctg ccgcttaccg gatacctgtc     5340

cgcctttctc ccttcgggaa gcgtggcgct ttctcatagc tcacgctgta ggtatctcag     5400

ttcggtgtag gtcgttcgct ccaagctggg ctgtgtgcac gaaccccccg ttcagcccga     5460

ccgctgcgcc ttatccggta actatcgtct tgagtccaac ccggtaagac acgacttatc     5520

gccactggca gcagccactg gtaacaggat tagcagagcg aggtatgtag gcggtgctac     5580

agagttcttg aagtggtggc ctaactacgg ctacactaga aggacagtat ttggtatctg     5640

cgctctgctg aagccagtta ccttcggaaa aagagttggt agctcttgat ccggcaaaca     5700

aaccaccgct ggtagcggtg gtttttttgt ttgcaagcag cagattacgc gcagaaaaaa     5760

aggatctcaa gaagatcctt tgatcttttc tacggggtct gacgctcagt ggaacgaaaa     5820

ctcacgttaa gggattttgg tcatgagatt atcaaaaagg atcttcacct agatcctttt     5880

aaattaaaaa tgaagtttta aatcaatcta aagtatatat gagtaaactt ggtctgacag     5940

ttaccaatgc ttaatcagtg aggcacctat ctcagcgatc tgtctatttc gttcatccat     6000

agttgcctga ctccccgtcg tgtagataac tacgatacgg gagggcttac catctggccc     6060

cagtgctgca atgataccgc gagacccacg ctcaccggct ccagatttat cagcaataaa     6120

ccagccagcc ggaagggccg agcgcagaag tggtcctgca actttatccg cctccatcca     6180

gtctattaat tgttgccggg aagctagagt aagtagttcg ccagttaata gtttgcgcaa     6240

cgttgttgcc attgctacag gcatcgtggt gtcacgctcg tcgtttggta tggcttcatt     6300

cagctccggt tcccaacgat caaggcgagt tacatgatcc cccatgttgt gcaaaaaagc     6360

ggttagctcc ttcggtcctc cgatcgttgt cagaagtaag ttggccgcag tgttatcact     6420

catggttatg gcagcactgc ataattctct tactgtcatg ccatccgtaa gatgcttttc     6480

tgtgactggt gagtactcaa ccaagtcatt ctgagaatag tgtatgcggc gaccgagttg     6540

ctcttgcccg gcgtcaatac gggataatac cgcgccacat agcagaactt taaaagtgct     6600

catcattgga aaacgttctt cggggcgaaa actctcaagg atcttaccgc tgttgagatc     6660

cagttcgatg taacccactc gtgcacccaa ctgatcttca gcatctttta ctttcaccag     6720

cgtttctggg tgagcaaaaa caggaaggca aaatgccgca aaaaagggaa taagggcgac     6780

acggaaatgt tgaatactca tactcttcct ttttcaatat tattgaagca tttatcaggg     6840

ttattgtctc atgagcggat acatatttga atgtatttag aaaaataaac aaataggggt     6900

tccgcgcaca tttccccgaa aagtgccacc tgacgtctaa gaaaccatta ttatcatgac     6960

attaacctat aaaaataggc gtatcacgag gccctttcgt c                         7001


<210>  23
<211>  606
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Secuencia que codifica para el dominio de unin al ADN del 
       represor transcripcional LexA


<220>
<221>  CDS
<222>  (1)..(606)

<400>  23
atg aaa gcg tta acg gcc agg caa caa gag gtg ttt gat ctc atc cgt         48
Met Lys Ala Leu Thr Ala Arg Gln Gln Glu Val Phe Asp Leu Ile Arg           
1               5                   10                  15                

gat cac atc agc cag aca ggt atg ccg ccg acg cgt gcg gaa atc gcg         96
Asp His Ile Ser Gln Thr Gly Met Pro Pro Thr Arg Ala Glu Ile Ala           
            20                  25                  30                    

cag cgt ttg ggg ttc cgt tcc cca aac gcg gct gaa gaa cat ctg aag        144
Gln Arg Leu Gly Phe Arg Ser Pro Asn Ala Ala Glu Glu His Leu Lys           
        35                  40                  45                        

gcg ctg gca cgc aaa ggc gtt att gaa att gtt tcc ggc gca tca cgc        192
Ala Leu Ala Arg Lys Gly Val Ile Glu Ile Val Ser Gly Ala Ser Arg           
    50                  55                  60                            

ggg att cgt ctg ttg cag gaa gag gaa gaa ggg ttg ccg ctg gta ggt        240
Gly Ile Arg Leu Leu Gln Glu Glu Glu Glu Gly Leu Pro Leu Val Gly           
65                  70                  75                  80            

cgt gtg gct gcc ggt gaa cca ctt ctg gcg caa cag cat att gaa ggt        288
Arg Val Ala Ala Gly Glu Pro Leu Leu Ala Gln Gln His Ile Glu Gly           
                85                  90                  95                

cat tat cag gtc gat cct tcc tta ttc aag ccg aat gct gat ttc ctg        336
His Tyr Gln Val Asp Pro Ser Leu Phe Lys Pro Asn Ala Asp Phe Leu           
            100                 105                 110                   

ctg cgc gtc agc ggg atg tcg atg aaa gat atc ggc att atg gat ggt        384
Leu Arg Val Ser Gly Met Ser Met Lys Asp Ile Gly Ile Met Asp Gly           
        115                 120                 125                       

gac ttg ctg gca gtg cat aaa act cag gat gta cgt aac ggt cag gtc        432
Asp Leu Leu Ala Val His Lys Thr Gln Asp Val Arg Asn Gly Gln Val           
    130                 135                 140                           

gtt gtc gca cgt att gat gac gaa gtt acc gtt aag cgc ctg aaa aaa        480
Val Val Ala Arg Ile Asp Asp Glu Val Thr Val Lys Arg Leu Lys Lys           
145                 150                 155                 160           

cag ggc aat aaa gtc gaa ctg ttg cca gaa aat agc gag ttt aaa cca        528
Gln Gly Asn Lys Val Glu Leu Leu Pro Glu Asn Ser Glu Phe Lys Pro           
                165                 170                 175               

att gtc gta gat ctt cgt cag cag agc ttc acc att gaa ggg ctg gcg        576
Ile Val Val Asp Leu Arg Gln Gln Ser Phe Thr Ile Glu Gly Leu Ala           
            180                 185                 190                   

gtt ggg gtt att cgc aac ggc gac tgg ctg                                606
Val Gly Val Ile Arg Asn Gly Asp Trp Leu                                   
        195                 200                                           


<210>  24
<211>  202
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  24

Met Lys Ala Leu Thr Ala Arg Gln Gln Glu Val Phe Asp Leu Ile Arg 
1               5                   10                  15      


Asp His Ile Ser Gln Thr Gly Met Pro Pro Thr Arg Ala Glu Ile Ala 
            20                  25                  30          


Gln Arg Leu Gly Phe Arg Ser Pro Asn Ala Ala Glu Glu His Leu Lys 
        35                  40                  45              


Ala Leu Ala Arg Lys Gly Val Ile Glu Ile Val Ser Gly Ala Ser Arg 
    50                  55                  60                  


Gly Ile Arg Leu Leu Gln Glu Glu Glu Glu Gly Leu Pro Leu Val Gly 
65                  70                  75                  80  


Arg Val Ala Ala Gly Glu Pro Leu Leu Ala Gln Gln His Ile Glu Gly 
                85                  90                  95      


His Tyr Gln Val Asp Pro Ser Leu Phe Lys Pro Asn Ala Asp Phe Leu 
            100                 105                 110         


Leu Arg Val Ser Gly Met Ser Met Lys Asp Ile Gly Ile Met Asp Gly 
        115                 120                 125             


Asp Leu Leu Ala Val His Lys Thr Gln Asp Val Arg Asn Gly Gln Val 
    130                 135                 140                 


Val Val Ala Arg Ile Asp Asp Glu Val Thr Val Lys Arg Leu Lys Lys 
145                 150                 155                 160 


Gln Gly Asn Lys Val Glu Leu Leu Pro Glu Asn Ser Glu Phe Lys Pro 
                165                 170                 175     


Ile Val Val Asp Leu Arg Gln Gln Ser Phe Thr Ile Glu Gly Leu Ala 
            180                 185                 190         


Val Gly Val Ile Arg Asn Gly Asp Trp Leu 
        195                 200         


<210>  25
<211>  703
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Promotor de ADH1 en el plsmido pLexA(1-202)PL

<400>  25
ccttttgttg tttccgggtg tacaatatgg acttcctctt ttctggcaac caaacccata       60

catcgggatt cctataatac cttcgttggt ctccctaaca tgtaggtggc ggaggggaga      120

tatacaatag aacagatacc agacaagaca taatgggcta aacaagacta caccaattac      180

actgcctcat tgatggtggt acataacgaa ctaatactgt agccctagac ttgatagcca      240

tcatcatatc gaagtttcac tacccttttt ccatttgcca tctattgaag taataatagg      300

cgcatgcaac ttcttttctt tttttttctt ttctctctcc cccgttgttg tctcaccata      360

tccgcaatga caaaaaaaat gatggaagac actaaaggaa aaaattaacg acaaagacag      420

caccaacaga tgtcgttgtt ccagagctga tgaggggtat cttcgaacac acgaaacttt      480

ttccttcctt cattcacgca cactactctc taatgagcaa cggtatacgg ccttccttcc      540

agttacttga atttgaaata aaaaaagttt gccgctttgc tatcaagtat aaatagacct      600

gcaattatta atcttttgtt tcctcgtcat tgttctcgtt ccctttcttc cttgtttctt      660

tttctgcaca atatttcaag ctataccaag catacaatca act                        703


<210>  26
<211>  193
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Terminador de ADH1 en el plsmido pLexA(1-202)PL

<400>  26
gcgaatttct tatgatttat gatttttatt attaaataag ttataaaaaa aataagtgta       60

tacaaatttt aaagtgactc ttaggtttta aaacgaaaat tcttgttctt gagtaactct      120

ttcctgtagg tcaggttgct ttctcaggta tagcatgagg tcgctcttat tgaccacacc      180

tctaccggca tgc                                                         193


<210>  27
<211>  10144
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Plsmido pLexA(1-200)PL

<400>  27
agctgcatgt gtcagaggtt ttcaccgtca tcaccgaaac gcgcgaggca ggatgatccg       60

ggatcgaaga aatgatggta aatgaaatag gaaatcaagg agcatgaagg caaaagacaa      120

atataagggt cgaacgaaaa ataaagtgaa aagtgttgat atgatgtatt tggctttgcg      180

gcgccgaaaa aacgagttta cgcaattgca caatcatgct gactctgtgg cggacccgcg      240

ctcttgccgg cccggcgata acgctgggcg tgaggctgtg cccggcggag ttttttgcgc      300

ctgcattttc caaggtttac cctgcgctaa ggggcgagat tggagaagca ataagaatgc      360

cggttggggt tgcgatgatg acgaccacga caactggtgt cattatttaa gttgccgaaa      420

gaacctgagt gcatttgcaa catgagtata ctagaagaat gagccaagac ttgcgagacg      480

cgagtttgcc ggtggtgcga acaatagagc gaccatgacc ttgaaggtga gacgcgcata      540

accgctagag tactttgaag aggaaacagc aatagggttg ctaccagtat aaatagacag      600

gtacatacaa cactggaaat ggttgtctgt ttgagtacgc tttcaattca tttgggtgtg      660

cactttatta tgttacaata tggaagggaa ctttacactt ctcctatgca catatattaa      720

ttaaagtcca atgctagtag agaagggggg taacacccct ccgcgctctt ttccgatttt      780

tttctaaacc gtggaatatt tcggatatcc ttttgttgtt tccgggtgta caatatggac      840

ttcctctttt ctggcaacca aacccataca tcgggattcc tataatacct tcgttggtct      900

ccctaacatg taggtggcgg aggggagata tacaatagaa cagataccag acaagacata      960

atgggctaaa caagactaca ccaattacac tgcctcattg atggtggtac ataacgaact     1020

aatactgtag ccctagactt gatagccatc atcatatcga agtttcacta ccctttttcc     1080

atttgccatc tattgaagta ataataggcg catgcaactt cttttctttt tttttctttt     1140

ctctctcccc cgttgttgtc tcaccatatc cgcaatgaca aaaaaaatga tggaagacac     1200

taaaggaaaa aattaacgac aaagacagca ccaacagatg tcgttgttcc agagctgatg     1260

aggggtatct tcgaacacac gaaacttttt ccttccttca ttcacgcaca ctactctcta     1320

atgagcaacg gtatacggcc ttccttccag ttacttgaat ttgaaataaa aaaagtttgc     1380

cgctttgcta tcaagtataa atagacctgc aattattaat cttttgtttc ctcgtcattg     1440

ttctcgttcc ctttcttcct tgtttctttt tctgcacaat atttcaagct ataccaagca     1500

tacaatcaac tccaagcttg aattaattcc gggcggaatg aaagcgttaa cggccaggca     1560

acaagaggtg tttgatctca tccgtgatca catcagccag acaggtatgc cgccgacgcg     1620

tgcggaaatc gcgcagcgtt tggggttccg ttccccaaac gcggctgaag aacatctgaa     1680

ggcgctggca cgcaaaggcg ttattgaaat tgtttccggc gcatcacgcg ggattcgtct     1740

gttgcaggaa gaggaagaag ggttgccgct ggtaggtcgt gtggctgccg gtgaaccact     1800

tctggcgcaa cagcatattg aaggtcatta tcaggtcgat ccttccttat tcaagccgaa     1860

tgctgatttc ctgctgcgcg tcagcgggat gtcgatgaaa gatatcggca ttatggatgg     1920

tgacttgctg gcagtgcata aaactcagga tgtacgtaac ggtcaggtcg ttgtcgcacg     1980

tattgatgac gaagttaccg ttaagcgcct gaaaaaacag ggcaataaag tcgaactgtt     2040

gccagaaaat agcgagttta aaccaattgt cgtagatctt cgtcagcaga gcttcaccat     2100

tgaagggctg gcggttgggg ttattcgcaa cggcgactgg ctggaattcc cggggatccg     2160

tcgacctgca gccaagctaa ttccgggcga atttcttatg atttatgatt tttattatta     2220

aataagttat aaaaaaaata agtgtataca aattttaaag tgactcttag gttttaaaac     2280

gaaaattctt gttcttgagt aactctttcc tgtaggtcag gttgctttct caggtatagc     2340

atgaggtcgc tcttattgac cacacctcta ccggcatgcc gagcaaatgc ctgcaaatcg     2400

ctccccattt cacccaattg tagatatgct aactccagca atgagttgat gaatctcggt     2460

gtgtatttta tgtcctcaga ggacaacacc tgttgtaatc gttcttccac acggatcgat     2520

ccacaggacg ggtgtggtcg ccatgatcgc gtagtcgata gtggctccaa gtagcgaagc     2580

gagcaggact gggcggcggc caaagcggtc ggacagtgct ccgagaacgg gtgcgcatag     2640

aaattgcatc aacgcatata gcgctagcag cacgccatag tgactggcga tgctgtcgga     2700

atggacgata tcccgcaaga ggcccggcag taccggcata accaagccta tgcctacagc     2760

atccagggtg acggtgccga ggatgacgat gagcgcattg ttagatttca tacacggtgc     2820

ctgactgcgt tagcaattta actgtgataa actaccgcat taaagctagc tttgaagaaa     2880

aatgcgcctt attcaatctt tgctataaaa aatggcccaa aatctcacat tggaagacat     2940

ttgatgacct catttctttc aatgaagggc ctaacggagt tgactaatgt tgtgggaaat     3000

tggagcgata agcgtgcttc tgccgtggcc aggacaacgt atactcatca gataacagca     3060

atacctgatc actacttcgc actagtttct cggtactatg catatgatcc aatatcaaag     3120

gaaatgatag cattgaagga tgagactaat ccaattgagg agtggcagca tatagaacag     3180

ctaaagggta gtgctgaagg aagcatacga taccccgcat ggaatgggat aatatcacag     3240

gaggtactag actacctttc atcctacata aatagacgca tataagtacg catttaagca     3300

taaacacgca ctatgccgtt cttctcatgt atatatatat acaggcaaca cgcagatata     3360

ggtgcgacgt gaacagtgag ctgtatgtgc gcagctcgcg ttgcattttc ggaagcgctc     3420

gttttcggaa acgctttgaa gttcctattc cgaagttcct attctctaga aagtatagga     3480

acttcagagc gcttttgaaa accaaaagcg ctctgaagac gcactttcaa aaaaccaaaa     3540

acgcaccgga ctgtaacgag ctactaaaat attgcgaata ccgcttccac aaacattgct     3600

caaaagtatc tctttgctat atatctctgt gctatatccc tatataacct acccatccac     3660

ctttcgctcc ttgaacttgc atctaaactc gacctctaca ttttttatgt ttatctctag     3720

tattactctt tagacaaaaa aattgtagta agaactattc atagagtgaa tcgaaaacaa     3780

tacgaaaatg taaacatttc ctatacgtag tatatagaga caaaatagaa gaaaccgttc     3840

ataattttct gaccaatgaa gaatcatcaa cgctatcact ttctgttcac aaagtatgcg     3900

caatccacat cggtatagaa tataatcggg gatgccttta tcttgaaaaa atgcacccgc     3960

agcttcgcta gtaatcagta aacgcgggaa gtggagtcag gcttttttta tggaagagaa     4020

aatagacacc aaagtagcct tcttctaacc ttaacggacc tacagtgcaa aaagttatca     4080

agagactgca ttatagagcg cacaaaggag aaaaaaagta atctaagatg ctttgttaga     4140

aaaatagcgc tctcgggatg catttttgta gaacaaaaaa gaagtataga ttctttgttg     4200

gtaaaatagc gctctcgcgt tgcatttctg ttctgtaaaa atgcagctca gattctttgt     4260

ttgaaaaatt agcgctctcg cgttgcattt ttgttttaca aaaatgaagc acagattctt     4320

cgttggtaaa atagcgcttt cgcgttgcat ttctgttctg taaaaatgca gctcagattc     4380

tttgtttgaa aaattagcgc tctcgcgttg catttttgtt ctacaaaatg aagcacagat     4440

gcttcgttaa caaagatatg ctattgaagt gcaagatgga aacgcagaaa atgaaccggg     4500

gatgcgacgt gcaagattac ctatgcaata gatgcaatag tttctccagg aaccgaaata     4560

catacattgt cttccgtaaa gcgctagact atatattatt atacaggttc aaatatacta     4620

tctgtttcag ggaaaactcc caggttcgga tgttcaaaat tcaatgatgg gtaacaagta     4680

cgatcgtaaa tctgtaaaac agtttgtcgg atattaggct gtatctcctc aaagcgtatt     4740

cgaatatcat tgagaagctg cagcaggcgt gaagttagac gacaacttct ctctggaaac     4800

gcataccgat attcaggctg ctgcaaaggc acaggctagt gcccgtgcga gtgcatccgg     4860

taccacccca gatgctgtag tagcttctgg tagcactgca atgagccatg cttatcaaga     4920

aaacacaggt tttggtactc gtcccatata tcttgacatg caagccacta caccaacaga     4980

ccctagggtt ttggatacga tgttgaagtt ttatacggga ctttatggta atcctcattc     5040

caacactcac tcttacggtt gggaaacaaa tactgctgtg gaaaatgcta gagctcacgt     5100

agcaaagatg atcaatgccg accccaagga aataatattc acttcgggag cgaccgaatc     5160

taataatatg gttcttaagg gtgtcccaag attttataag aagactaaga aacacatcat     5220

caccactaga acggaacaca agtgtgtctt ggaagccgca cgggccatga tgaaggaggg     5280

atttgaagtc actttcctaa atgtggacga tcaaggtctt atcgatttga aggaattgga     5340

agatgccatt agaccagata cctgtctcgt ctctgtgatg gctgtcaata atgaaatcgg     5400

tgtcattcaa cctattaaag aaattggagc aatttgtaga aagaataaga tcctcgggga     5460

caccaaatat ggcgatctcg gccttttcgt ttcttggagc tgggacatgt ttgccatcga     5520

tccatctacc accagaacgg ccgttagatc tgctgccacc gttgtttcca ccgaagaaac     5580

caccgttgcc gtaaccacca cgacggttgt tgctaaagaa gctgccaccg ccacggccac     5640

cgttgtagcc gccgttgttg ttattgtagt tgctactgtt atttctggca cttcttggtt     5700

ttcctcttaa gtgaggagga acataaccat tctcgttgtt gtcgttgatg cttaaatttt     5760

gcacttgttc gctcagttca gccataatat gaaatgcttt tcttgttgtt cttacggaat     5820

accacttgcc acctatcacc acaactaact ttttcccgtt cctccatctc ttttatattt     5880

tttttctcga tcgagttcaa gagaaaaaaa aagaaaaagc aaaaagaaaa aaggaaagcg     5940

cgcctcgttc agaatgacac gtatagaatg atgcattacc ttgtcatctt cagtatcata     6000

ctgttcgtat acatacttac tgacattcat aggtatacat atatacacat gtatatatat     6060

cgtatgctgc agctttaaat aatcggtgtc actacataag aacacctttg gtggagggaa     6120

catcgttggt accattgggc gaggtggctt ctcttatggc aaccgcaaga gccttgaacg     6180

cactctcact acggtgatga tcattcttgc ctcgcagaca atcaacgtgg agggtaattc     6240

tgctagcctc tgcaaagctt tcaagaaaat gcgggatcat ctcgcaagag agatctccta     6300

ctttctccct ttgcaaacca agttcgacaa ctgcgtacgg cctgttcgaa agatctacca     6360

ccgctctgga aagtgcctca tccaaaggcg caaatcctga tccaaacctt tttactccac     6420

gcgccagtag ggcctcttta aaagcttgac cgagagcaat cccgcagtct tcagtggtgt     6480

gatggtcgtc tatgtgtaag tcaccaatgc actcaacgat tagcgaccag ccggaatgct     6540

tggccagagc atgtatcata tggtccagaa accctatacc tgtgtggacg ttaatcactt     6600

gcgattgtgt ggcctgttct gctactgctt ctgcctcttt ttctgggaag atcgagtgct     6660

ctatcgctag gggaccaccc tttaaagaga tcgcaatctg aatcttggtt tcatttgtaa     6720

tacgctttac tagggctttc tgctctgtca tctttgcctt cgtttatctt gcctgctcat     6780

tttttagtat attcttcgaa gaaatcacat tactttatat aatgtataat tcattatgtg     6840

ataatgccaa tcgctaagaa aaaaaaagag tcatccgcta ggtggaaaaa aaaaaatgaa     6900

aatcattacc gaggcataaa aaaatataga gtgtactaga ggaggccaag agtaatagaa     6960

aaagaaaatt gcgggaaagg actgtgttat gacttccctg actaatgccg tgttcaaacg     7020

atacctggca gtgactccta gcgctcacca agctcttaaa acgagaatta agaaaaagtc     7080

gtcatctttc gataagtttt tcccacagca aagcaatagt agaaaaacaa tgggaaacgt     7140

tgaatgaaga caaagcgtcg tggtttaaaa ggaaatacgc tcacgtacat gctagggaac     7200

aggaccgtgc agcggatcta atgaatccat ttgttagtta atagtttaaa tgtttttatc     7260

ggaagaggtt ttgtcatcac atcagcaatg ttcttcttgg tctcgatgta gtatacgtat     7320

aaattattac ctgatacttc atctctaagt ctcattgcct ttgtgccaaa aaatctgttt     7380

ctaaatttct cttcatttgt agacttaatt atactgatcg ttgatctact atcagtaagt     7440

aagcctttaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaac ctgtaacaat agcaataccc     7500

caaataccta atgtagttcc agcaagcaag ctaaaaagta aagcaacaac ataactcacc     7560

cctgcatctg cagcttttgc ccgggcagcc tgctctgcct gtgttttctt taattgagca     7620

gtagaccatt tagcagttgc atgaatagct gcagcgtcac atcggataat aatgatggca     7680

gccattgtag aagtgccttt tgcatttcta gtctctttct cggtctagct agttttacta     7740

catcgcgaag atagaatctt agatcacact gcctttgctg agctggatca atagagtaac     7800

aaaagagtgg taaggcctcg ttaaaggaca aggacctgag cggaagtgta tcgtacagta     7860

gacggagtat actagtatag tctatagtcc gtggaattaa ttcttgaaga cgaaagggcc     7920

tcgtgatacg cctattttta taggttaatg tcatgataat aatggtttct tagacgtcag     7980

gtggcacttt tcggggaaat gtgcgcggaa cccctatttg tttatttttc taaatacatt     8040

caaatatgta tccgctcatg agacaataac cctgataaat gcttcaataa tattgaaaaa     8100

ggaagagtat gagtattcaa catttccgtg tcgcccttat tccctttttt gcggcatttt     8160

gccttcctgt ttttgctcac ccagaaacgc tggtgaaagt aaaagatgct gaagatcagt     8220

tgggtgcacg agtgggttac atcgaactgg atctcaacag cggtaagatc cttgagagtt     8280

ttcgccccga agaacgtttt ccaatgatga gcacttttaa agttctgcta tgtggcgcgg     8340

tattatcccg tgttgacgcc gggcaagagc aactcggtcg ccgcatacac tattctcaga     8400

atgacttggt tgagtactca ccagtcacag aaaagcatct tacggatggc atgacagtaa     8460

gagaattatg cagtgctgcc ataaccatga gtgataacac tgcggccaac ttacttctga     8520

caacgatcgg aggaccgaag gagctaaccg cttttttgca caacatgggg gatcatgtaa     8580

ctcgccttga tcgttgggaa ccggagctga atgaagccat accaaacgac gagcgtgaca     8640

ccacgatgcc tgcagcaatg gcaacaacgt tgcgcaaact attaactggc gaactactta     8700

ctctagcttc ccggcaacaa ttaatagact ggatggaggc ggataaagtt gcaggaccac     8760

ttctgcgctc ggcccttccg gctggctggt ttattgctga taaatctgga gccggtgagc     8820

gtgggtctcg cggtatcatt gcagcactgg ggccagatgg taagccctcc cgtatcgtag     8880

ttatctacac gacggggagt caggcaacta tggatgaacg aaatagacag atcgctgaga     8940

taggtgcctc actgattaag cattggtaac tgtcagacca agtttactca tatatacttt     9000

agattgattt aaaacttcat ttttaattta aaaggatcta ggtgaagatc ctttttgata     9060

atctcatgac caaaatccct taacgtgagt tttcgttcca ctgagcgtca gaccccgtag     9120

aaaagatcaa aggatcttct tgagatcctt tttttctgcg cgtaatctgc tgcttgcaaa     9180

caaaaaaacc accgctacca gcggtggttt gtttgccgga tcaagagcta ccaactcttt     9240

ttccgaaggt aactggcttc agcagagcgc agataccaaa tactgtcctt ctagtgtagc     9300

cgtagttagg ccaccacttc aagaactctg tagcaccgcc tacatacctc gctctgctaa     9360

tcctgttacc agtggctgct gccagtggcg ataagtcgtg tcttaccggg ttggactcaa     9420

gacgatagtt accggataag gcgcagcggt cgggctgaac ggggggttcg tgcacacagc     9480

ccagcttgga gcgaacgacc tacaccgaac tgagatacct acagcgtgag ctatgagaaa     9540

gcgccacgct tcccgaaggg agaaaggcgg acaggtatcc ggtaagcggc agggtcggaa     9600

caggagagcg cacgagggag cttccagggg gaaacgcctg gtatctttat agtcctgtcg     9660

ggtttcgcca cctctgactt gagcgtcgat ttttgtgatg ctcgtcaggg gggcggagcc     9720

tatggaaaaa cgccagcaac gcggcctttt tacggttcct ggccttttgc tggccttttg     9780

ctcacatgtt ctttcctgcg ttatcccctg attctgtgga taaccgtatt accgcctttg     9840

agtgagctga taccgctcgc cgcagccgaa cgaccgagcg cagcgagtca gtgagcgagg     9900

aagcggaaga gcgcctgatg cggtattttc tccttacgca tctgtgcggt atttcacacc     9960

gcatatggtg cactctcagt acaatctgct ctgatgccgc atagttaagc cagtatacac    10020

tccgctatcg ctacgtgact gggtcatggc tgcgccccga cacccgccaa cacccgctga    10080

cgcgccctga cgggcttgtc tgctcccggc atccgcttac agacaagctg tgaccgtctc    10140

cggg                                                                 10144


<210>  28
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Cebador OV502

<400>  28
gggtaccttt tgttgtttcc gggtgtac                                          28


<210>  29
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Cebador OV503

<400>  29
ggagctcgca tgccggtaga ggtgtggtc                                         29


<210>  30
<211>  8182
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Plsmido pRS402-LexA-Tsg101

<400>  30
tcgcgcgttt cggtgatgac ggtgaaaacc tctgacacat gcagctcccg gagacggtca       60

cagcttgtct gtaagcggat gccgggagca gacaagcccg tcagggcgcg tcagcgggtg      120

ttggcgggtg tcggggctgg cttaactatg cggcatcaga gcagattgta ctgagagtgc      180

accatagatc tgaattaatt cttgaataat acataacttt tcttaaaaga atcaaagaca      240

gataaaattt aagagatatt aaatattagt gagaagccga gaattttgta acaccaacat      300

aacactgaca tctttaacaa cttttaatta tgatacattt cttacgtcat gattgattat      360

tacagctatg ctgacaaatg actcttgttg catggctacg aaccgggtaa tactaagtga      420

ttgactcttg ctgacctttt attaagaact aaatggacaa tattatggag catttcatgt      480

ataaattggt gcgtaaaatc gttggatctc tcttctaagt acatcctact ataacaatca      540

agaaaaacaa gaaaatcgga caaaacaatc aagtatggat tctagaacag ttggtatatt      600

aggaggggga caattgggac gtatgattgt tgaggcagca aacaggctca acattaagac      660

ggtaatacta gatgctgaaa attctcctgc caaacaaata agcaactcca atgaccacgt      720

taatggctcc ttttccaatc ctcttgatat cgaaaaacta gctgaaaaat gtgatgtgct      780

aacgattgag attgagcatg ttgatgttcc tacactaaag aatcttcaag taaaacatcc      840

caaattaaaa atttaccctt ctccagaaac aatcagattg atacaagaca aatatattca      900

aaaagagcat ttaatcaaaa atggtatagc agttacccaa agtgttcctg tggaacaagc      960

cagtgagacg tccctattga atgttggaag agatttgggt tttccattcg tcttgaagtc     1020

gaggactttg gcatacgatg gaagaggtaa cttcgttgta aagaataagg aaatgattcc     1080

ggaagctttg gaagtactga aggatcgtcc tttgtacgcc gaaaaatggg caccatttac     1140

taaagaatta gcagtcatga ttgtgaggtc tgttaacggt ttagtgtttt cttacccaat     1200

tgtagagact atccacaagg acaatatttg tgacttatgt tatgcgcctg ctagagttcc     1260

ggactccgtt caacttaagg cgaagttgtt ggcagaaaat gcaatcaaat cttttcccgg     1320

ttgtggtata tttggtgtgg aaatgttcta tttagaaaca ggggaattgc ttattaacga     1380

aattgcccca aggcctcaca actctggaca ttataccatt gatgcttgcg tcacttctca     1440

atttgaagct catttgagat caatattgga tttgccaatg ccaaagaatt tcacatcttt     1500

ctccaccatt acaacgaacg ccattatgct aaatgttctt ggagacaaac atacaaaaga     1560

taaagagcta gaaacttgcg aaagagcatt ggcgactcca ggttcctcag tgtacttata     1620

tggaaaagag tctagaccta acagaaaagt aggtcacata aatattattg cctccagtat     1680

ggcggaatgt gaacaaaggc tgaactacat tacaggtaga actgatattc caatcaaaat     1740

ctctgtcgct caaaagttgg acttggaagc aatggtcaaa ccattggttg gaatcatcat     1800

gggatcagac tctgacttgc cggtaatgtc tgccgcatgt gcggttttaa aagattttgg     1860

cgttccattt gaagtgacaa tagtctctgc tcatagaact ccacatagga tgtcagcata     1920

tgctatttcc gcaagcaagc gtggaattaa aacaattatc gctggagctg gtggggctgc     1980

tcacttgcca ggtatggtgg ctgcaatgac accacttcct gtcatcggtg tgcccgtaaa     2040

aggttcttgt ctagatggag tagattcttt acattcaatt gtgcaaatgc ctagaggtgt     2100

tccagtagct accgtcgcta ttaataatag tacgaacgct gcgctgttgg ctgtcagact     2160

gcttggcgct tatgattcaa gttatacaac gaaaatggaa cagtttttat taaagcaaga     2220

agaagaagtt cttgtcaaag cacaaaagtt agaaactgtc ggttacgaag cttatctaga     2280

aaacaagtaa tatataagtt tattgatata cttgtacagc aaataattat aaaatgatat     2340

acctattttt taggctttgt tatgattaca tcaaatgtgg acttcataca tagaaatcaa     2400

cgcttacagg tgtccttttt taagaatttc atacataaga tctatgcggt gtgaaatacc     2460

gcacagatgc gtaaggagaa aataccgcat caggaaattg taaacgttaa tattttgtta     2520

aaattcgcgt taaatttttg ttaaatcagc tcatttttta accaataggc cgaaatcggc     2580

aaaatccctt ataaatcaaa agaatagacc gagatagggt tgagtgttgt tccagtttgg     2640

aacaagagtc cactattaaa gaacgtggac tccaacgtca aagggcgaaa aaccgtctat     2700

cagggcgatg gcccactacg tgaaccatca ccctaatcaa gttttttggg gtcgaggtgc     2760

cgtaaagcac taaatcggaa ccctaaaggg agcccccgat ttagagcttg acggggaaag     2820

ccggcgaacg tggcgagaaa ggaagggaag aaagcgaaag gagcgggcgc tagggcgctg     2880

gcaagtgtag cggtcacgct gcgcgtaacc accacacccg ccgcgcttaa tgcgccgcta     2940

cagggcgcgt cgcgccattc gccattcagg ctgcgcaact gttgggaagg gcgatcggtg     3000

cgggcctctt cgctattacg ccagctggcg aaagggggat gtgctgcaag gcgattaagt     3060

tgggtaacgc cagggttttc ccagtcacga cgttgtaaaa cgacggccag tgagcgcgcg     3120

taatacgact cactataggg cgaattgggt accttttgtt gtttccgggt gtacaatatg     3180

gacttcctct tttctggcaa ccaaacccat acatcgggat tcctataata ccttcgttgg     3240

tctccctaac atgtaggtgg cggaggggag atatacaata gaacagatac cagacaagac     3300

ataatgggct aaacaagact acaccaatta cactgcctca ttgatggtgg tacataacga     3360

actaatactg tagccctaga cttgatagcc atcatcatat cgaagtttca ctaccctttt     3420

tccatttgcc atctattgaa gtaataatag gcgcatgcaa cttcttttct ttttttttct     3480

tttctctctc ccccgttgtt gtctcaccat atccgcaatg acaaaaaaaa tgatggaaga     3540

cactaaagga aaaaattaac gacaaagaca gcaccaacag atgtcgttgt tccagagctg     3600

atgaggggta tcttcgaaca cacgaaactt tttccttcct tcattcacgc acactactct     3660

ctaatgagca acggtatacg gccttccttc cagttacttg aatttgaaat aaaaaaagtt     3720

tgccgctttg ctatcaagta taaatagacc tgcaattatt aatcttttgt ttcctcgtca     3780

ttgttctcgt tccctttctt ccttgtttct ttttctgcac aatatttcaa gctataccaa     3840

gcatacaatc aactccaagc ttgaattaat tccgggcgga atgaaagcgt taacggccag     3900

gcaacaagag gtgtttgatc tcatccgtga tcacatcagc cagacaggta tgccgccgac     3960

gcgtgcggaa atcgcgcagc gtttggggtt ccgttcccca aacgcggctg aagaacatct     4020

gaaggcgctg gcacgcaaag gcgttattga aattgtttcc ggcgcatcac gcgggattcg     4080

tctgttgcag gaagaggaag aagggttgcc gctggtaggt cgtgtggctg ccggtgaacc     4140

acttctggcg caacagcata ttgaaggtca ttatcaggtc gatccttcct tattcaagcc     4200

gaatgctgat ttcctgctgc gcgtcagcgg gatgtcgatg aaagatatcg gcattatgga     4260

tggtgacttg ctggcagtgc ataaaactca ggatgtacgt aacggtcagg tcgttgtcgc     4320

acgtattgat gacgaagtta ccgttaagcg cctgaaaaaa cagggcaata aagtcgaact     4380

gttgccagaa aatagcgagt ttaaaccaat tgtcgtagat cttcgtcagc agagcttcac     4440

cattgaaggg ctggcggttg gggttattcg caacggcgac tggctggaat tcccggggat     4500

cctcatggcg gtgtcggaga gccagctcaa gaaaatggtg tccaagtaca aatacagaga     4560

cctaactgta cgtgaaactg tcaatgttat tactctatac aaagatctca aacctgtttt     4620

ggattcatat gtttttaacg atggcagttc cagggaacta atgaacctca ctggaacaat     4680

ccctgtgcct tatagaggta atacatacaa tattccaata tgcctatggc tactggacac     4740

atacccatat aatcccccta tctgttttgt taagcctact agttcaatga ctattaaaac     4800

aggaaagcat gttgatgcaa atgggaagat atatcttcct tatctacatg aatggaaaca     4860

cccacagtca gacttgttgg ggcttattca ggtcatgatt gtggtatttg gagatgaacc     4920

tccagtcttc tctcgtccta tttcggcatc ctatccgcca taccaggcaa cggggccacc     4980

aaatacttcc tacatgccag gcatgccagg tggaatctct ccatacccat ccggataccc     5040

tcccaatccc agtggttacc caggctgtcc ttacccacct ggtggtccat atcctgccac     5100

aacaagttct cagtaccctt ctcagcctcc tgtgaccact gttggtccca gtagggatgg     5160

cacaatcagc gaggacacca tccgagcctc tctcatctct gcggtcagtg acaaactgag     5220

atggcggatg aaggaggaaa tggatcgtgc ccaggcagag ctcaatgcct tgaaacgaac     5280

agaagaagac ctgaaaaagg gtcaccagaa actggaagag atggttaccc gtttagatca     5340

agaagtagcc gaggttgata aaaacataga acttttgaaa aagaaggatg aagaactcag     5400

ttctgctctg gaaaaaatgg aaaatcagtc tgaaaacaat gatatcgatg aagttatcat     5460

tcccacagct cccttataca aacagatcct gaatctgtat gcagaagaaa acgctattga     5520

agacactatc ctttacttgg gagaagcctt gagaaggggc gtgatagacc tggatgtctt     5580

cctgaagcat gtacgtcttc tgtcccgtaa acagttccag ctgagggcac taatgcaaaa     5640

agcaagaaag actgccggtc tcagtgacct ctactgagga tccgtcgacc tgcagccaag     5700

ctaattccgg gcgaatttct tatgatttat gatttttatt attaaataag ttataaaaaa     5760

aataagtgta tacaaatttt aaagtgactc ttaggtttta aaacgaaaat tcttgttctt     5820

gagtaactct ttcctgtagg tcaggttgct ttctcaggta tagcatgagg tcgctcttat     5880

tgaccacacc tctaccggca tgcgagctcc agcttttgtt ccctttagtg agggttaatt     5940

gcgcgcttgg cgtaatcatg gtcatagctg tttcctgtgt gaaattgtta tccgctcaca     6000

attccacaca acatacgagc cggaagcata aagtgtaaag cctggggtgc ctaatgagtg     6060

agctaactca cattaattgc gttgcgctca ctgcccgctt tccagtcggg aaacctgtcg     6120

tgccagctgc attaatgaat cggccaacgc gcggggagag gcggtttgcg tattgggcgc     6180

tcttccgctt cctcgctcac tgactcgctg cgctcggtcg ttcggctgcg gcgagcggta     6240

tcagctcact caaaggcggt aatacggtta tccacagaat caggggataa cgcaggaaag     6300

aacatgtgag caaaaggcca gcaaaaggcc aggaaccgta aaaaggccgc gttgctggcg     6360

tttttccata ggctccgccc ccctgacgag catcacaaaa atcgacgctc aagtcagagg     6420

tggcgaaacc cgacaggact ataaagatac caggcgtttc cccctggaag ctccctcgtg     6480

cgctctcctg ttccgaccct gccgcttacc ggatacctgt ccgcctttct cccttcggga     6540

agcgtggcgc tttctcatag ctcacgctgt aggtatctca gttcggtgta ggtcgttcgc     6600

tccaagctgg gctgtgtgca cgaacccccc gttcagcccg accgctgcgc cttatccggt     6660

aactatcgtc ttgagtccaa cccggtaaga cacgacttat cgccactggc agcagccact     6720

ggtaacagga ttagcagagc gaggtatgta ggcggtgcta cagagttctt gaagtggtgg     6780

cctaactacg gctacactag aaggacagta tttggtatct gcgctctgct gaagccagtt     6840

accttcggaa aaagagttgg tagctcttga tccggcaaac aaaccaccgc tggtagcggt     6900

ggtttttttg tttgcaagca gcagattacg cgcagaaaaa aaggatctca agaagatcct     6960

ttgatctttt ctacggggtc tgacgctcag tggaacgaaa actcacgtta agggattttg     7020

gtcatgagat tatcaaaaag gatcttcacc tagatccttt taaattaaaa atgaagtttt     7080

aaatcaatct aaagtatata tgagtaaact tggtctgaca gttaccaatg cttaatcagt     7140

gaggcaccta tctcagcgat ctgtctattt cgttcatcca tagttgcctg actccccgtc     7200

gtgtagataa ctacgatacg ggagggctta ccatctggcc ccagtgctgc aatgataccg     7260

cgagacccac gctcaccggc tccagattta tcagcaataa accagccagc cggaagggcc     7320

gagcgcagaa gtggtcctgc aactttatcc gcctccatcc agtctattaa ttgttgccgg     7380

gaagctagag taagtagttc gccagttaat agtttgcgca acgttgttgc cattgctaca     7440

ggcatcgtgg tgtcacgctc gtcgtttggt atggcttcat tcagctccgg ttcccaacga     7500

tcaaggcgag ttacatgatc ccccatgttg tgcaaaaaag cggttagctc cttcggtcct     7560

ccgatcgttg tcagaagtaa gttggccgca gtgttatcac tcatggttat ggcagcactg     7620

cataattctc ttactgtcat gccatccgta agatgctttt ctgtgactgg tgagtactca     7680

accaagtcat tctgagaata gtgtatgcgg cgaccgagtt gctcttgccc ggcgtcaata     7740

cgggataata ccgcgccaca tagcagaact ttaaaagtgc tcatcattgg aaaacgttct     7800

tcggggcgaa aactctcaag gatcttaccg ctgttgagat ccagttcgat gtaacccact     7860

cgtgcaccca actgatcttc agcatctttt actttcacca gcgtttctgg gtgagcaaaa     7920

acaggaaggc aaaatgccgc aaaaaaggga ataagggcga cacggaaatg ttgaatactc     7980

atactcttcc tttttcaata ttattgaagc atttatcagg gttattgtct catgagcgga     8040

tacatatttg aatgtattta gaaaaataaa caaatagggg ttccgcgcac atttccccga     8100

aaagtgccac ctgacgtcta agaaaccatt attatcatga cattaaccta taaaaatagg     8160

cgtatcacga ggccctttcg tc                                              8182


<210>  31
<211>  1173
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(1173)

<400>  31
atg gcg gtg tcg gag agc cag ctc aag aaa atg gtg tcc aag tac aaa         48
Met Ala Val Ser Glu Ser Gln Leu Lys Lys Met Val Ser Lys Tyr Lys           
1               5                   10                  15                

tac aga gac cta act gta cgt gaa act gtc aat gtt att act cta tac         96
Tyr Arg Asp Leu Thr Val Arg Glu Thr Val Asn Val Ile Thr Leu Tyr           
            20                  25                  30                    

aaa gat ctc aaa cct gtt ttg gat tca tat gtt ttt aac gat ggc agt        144
Lys Asp Leu Lys Pro Val Leu Asp Ser Tyr Val Phe Asn Asp Gly Ser           
        35                  40                  45                        

tcc agg gaa cta atg aac ctc act gga aca atc cct gtg cct tat aga        192
Ser Arg Glu Leu Met Asn Leu Thr Gly Thr Ile Pro Val Pro Tyr Arg           
    50                  55                  60                            

ggt aat aca tac aat att cca ata tgc cta tgg cta ctg gac aca tac        240
Gly Asn Thr Tyr Asn Ile Pro Ile Cys Leu Trp Leu Leu Asp Thr Tyr           
65                  70                  75                  80            

cca tat aat ccc cct atc tgt ttt gtt aag cct act agt tca atg act        288
Pro Tyr Asn Pro Pro Ile Cys Phe Val Lys Pro Thr Ser Ser Met Thr           
                85                  90                  95                

att aaa aca gga aag cat gtt gat gca aat ggg aag ata tat ctt cct        336
Ile Lys Thr Gly Lys His Val Asp Ala Asn Gly Lys Ile Tyr Leu Pro           
            100                 105                 110                   

tat cta cat gaa tgg aaa cac cca cag tca gac ttg ttg ggg ctt att        384
Tyr Leu His Glu Trp Lys His Pro Gln Ser Asp Leu Leu Gly Leu Ile           
        115                 120                 125                       

cag gtc atg att gtg gta ttt gga gat gaa cct cca gtc ttc tct cgt        432
Gln Val Met Ile Val Val Phe Gly Asp Glu Pro Pro Val Phe Ser Arg           
    130                 135                 140                           

cct att tcg gca tcc tat ccg cca tac cag gca acg ggg cca cca aat        480
Pro Ile Ser Ala Ser Tyr Pro Pro Tyr Gln Ala Thr Gly Pro Pro Asn           
145                 150                 155                 160           

act tcc tac atg cca ggc atg cca ggt gga atc tct cca tac cca tcc        528
Thr Ser Tyr Met Pro Gly Met Pro Gly Gly Ile Ser Pro Tyr Pro Ser           
                165                 170                 175               

gga tac cct ccc aat ccc agt ggt tac cca ggc tgt cct tac cca cct        576
Gly Tyr Pro Pro Asn Pro Ser Gly Tyr Pro Gly Cys Pro Tyr Pro Pro           
            180                 185                 190                   

ggt ggt cca tat cct gcc aca aca agt tct cag tac cct tct cag cct        624
Gly Gly Pro Tyr Pro Ala Thr Thr Ser Ser Gln Tyr Pro Ser Gln Pro           
        195                 200                 205                       

cct gtg acc act gtt ggt ccc agt agg gat ggc aca atc agc gag gac        672
Pro Val Thr Thr Val Gly Pro Ser Arg Asp Gly Thr Ile Ser Glu Asp           
    210                 215                 220                           

acc atc cga gcc tct ctc atc tct gcg gtc agt gac aaa ctg aga tgg        720
Thr Ile Arg Ala Ser Leu Ile Ser Ala Val Ser Asp Lys Leu Arg Trp           
225                 230                 235                 240           

cgg atg aag gag gaa atg gat cgt gcc cag gca gag ctc aat gcc ttg        768
Arg Met Lys Glu Glu Met Asp Arg Ala Gln Ala Glu Leu Asn Ala Leu           
                245                 250                 255               

aaa cga aca gaa gaa gac ctg aaa aag ggt cac cag aaa ctg gaa gag        816
Lys Arg Thr Glu Glu Asp Leu Lys Lys Gly His Gln Lys Leu Glu Glu           
            260                 265                 270                   

atg gtt acc cgt tta gat caa gaa gta gcc gag gtt gat aaa aac ata        864
Met Val Thr Arg Leu Asp Gln Glu Val Ala Glu Val Asp Lys Asn Ile           
        275                 280                 285                       

gaa ctt ttg aaa aag aag gat gaa gaa ctc agt tct gct ctg gaa aaa        912
Glu Leu Leu Lys Lys Lys Asp Glu Glu Leu Ser Ser Ala Leu Glu Lys           
    290                 295                 300                           

atg gaa aat cag tct gaa aac aat gat atc gat gaa gtt atc att ccc        960
Met Glu Asn Gln Ser Glu Asn Asn Asp Ile Asp Glu Val Ile Ile Pro           
305                 310                 315                 320           

aca gct ccc tta tac aaa cag atc ctg aat ctg tat gca gaa gaa aac       1008
Thr Ala Pro Leu Tyr Lys Gln Ile Leu Asn Leu Tyr Ala Glu Glu Asn           
                325                 330                 335               

gct att gaa gac act atc ctt tac ttg gga gaa gcc ttg aga agg ggc       1056
Ala Ile Glu Asp Thr Ile Leu Tyr Leu Gly Glu Ala Leu Arg Arg Gly           
            340                 345                 350                   

gtg ata gac ctg gat gtc ttc ctg aag cat gta cgt ctt ctg tcc cgt       1104
Val Ile Asp Leu Asp Val Phe Leu Lys His Val Arg Leu Leu Ser Arg           
        355                 360                 365                       

aaa cag ttc cag ctg agg gca cta atg caa aaa gca aga aag act gcc       1152
Lys Gln Phe Gln Leu Arg Ala Leu Met Gln Lys Ala Arg Lys Thr Ala           
    370                 375                 380                           

ggt ctc agt gac ctc tac tga                                           1173
Gly Leu Ser Asp Leu Tyr                                                   
385                 390                                                   


<210>  32
<211>  390
<212>  PRT
<213>  Homo sapiens

<400>  32

Met Ala Val Ser Glu Ser Gln Leu Lys Lys Met Val Ser Lys Tyr Lys 
1               5                   10                  15      


Tyr Arg Asp Leu Thr Val Arg Glu Thr Val Asn Val Ile Thr Leu Tyr 
            20                  25                  30          


Lys Asp Leu Lys Pro Val Leu Asp Ser Tyr Val Phe Asn Asp Gly Ser 
        35                  40                  45              


Ser Arg Glu Leu Met Asn Leu Thr Gly Thr Ile Pro Val Pro Tyr Arg 
    50                  55                  60                  


Gly Asn Thr Tyr Asn Ile Pro Ile Cys Leu Trp Leu Leu Asp Thr Tyr 
65                  70                  75                  80  


Pro Tyr Asn Pro Pro Ile Cys Phe Val Lys Pro Thr Ser Ser Met Thr 
                85                  90                  95      


Ile Lys Thr Gly Lys His Val Asp Ala Asn Gly Lys Ile Tyr Leu Pro 
            100                 105                 110         


Tyr Leu His Glu Trp Lys His Pro Gln Ser Asp Leu Leu Gly Leu Ile 
        115                 120                 125             


Gln Val Met Ile Val Val Phe Gly Asp Glu Pro Pro Val Phe Ser Arg 
    130                 135                 140                 


Pro Ile Ser Ala Ser Tyr Pro Pro Tyr Gln Ala Thr Gly Pro Pro Asn 
145                 150                 155                 160 


Thr Ser Tyr Met Pro Gly Met Pro Gly Gly Ile Ser Pro Tyr Pro Ser 
                165                 170                 175     


Gly Tyr Pro Pro Asn Pro Ser Gly Tyr Pro Gly Cys Pro Tyr Pro Pro 
            180                 185                 190         


Gly Gly Pro Tyr Pro Ala Thr Thr Ser Ser Gln Tyr Pro Ser Gln Pro 
        195                 200                 205             


Pro Val Thr Thr Val Gly Pro Ser Arg Asp Gly Thr Ile Ser Glu Asp 
    210                 215                 220                 


Thr Ile Arg Ala Ser Leu Ile Ser Ala Val Ser Asp Lys Leu Arg Trp 
225                 230                 235                 240 


Arg Met Lys Glu Glu Met Asp Arg Ala Gln Ala Glu Leu Asn Ala Leu 
                245                 250                 255     


Lys Arg Thr Glu Glu Asp Leu Lys Lys Gly His Gln Lys Leu Glu Glu 
            260                 265                 270         


Met Val Thr Arg Leu Asp Gln Glu Val Ala Glu Val Asp Lys Asn Ile 
        275                 280                 285             


Glu Leu Leu Lys Lys Lys Asp Glu Glu Leu Ser Ser Ala Leu Glu Lys 
    290                 295                 300                 


Met Glu Asn Gln Ser Glu Asn Asn Asp Ile Asp Glu Val Ile Ile Pro 
305                 310                 315                 320 


Thr Ala Pro Leu Tyr Lys Gln Ile Leu Asn Leu Tyr Ala Glu Glu Asn 
                325                 330                 335     


Ala Ile Glu Asp Thr Ile Leu Tyr Leu Gly Glu Ala Leu Arg Arg Gly 
            340                 345                 350         


Val Ile Asp Leu Asp Val Phe Leu Lys His Val Arg Leu Leu Ser Arg 
        355                 360                 365             


Lys Gln Phe Gln Leu Arg Ala Leu Met Gln Lys Ala Arg Lys Thr Ala 
    370                 375                 380                 


Gly Leu Ser Asp Leu Tyr 
385                 390 


<210>  33
<211>  11325
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Plsmido pLexA(1-200)PL-Tsg101

<400>  33
agctgcatgt gtcagaggtt ttcaccgtca tcaccgaaac gcgcgaggca ggatgatccg       60

ggatcgaaga aatgatggta aatgaaatag gaaatcaagg agcatgaagg caaaagacaa      120

atataagggt cgaacgaaaa ataaagtgaa aagtgttgat atgatgtatt tggctttgcg      180

gcgccgaaaa aacgagttta cgcaattgca caatcatgct gactctgtgg cggacccgcg      240

ctcttgccgg cccggcgata acgctgggcg tgaggctgtg cccggcggag ttttttgcgc      300

ctgcattttc caaggtttac cctgcgctaa ggggcgagat tggagaagca ataagaatgc      360

cggttggggt tgcgatgatg acgaccacga caactggtgt cattatttaa gttgccgaaa      420

gaacctgagt gcatttgcaa catgagtata ctagaagaat gagccaagac ttgcgagacg      480

cgagtttgcc ggtggtgcga acaatagagc gaccatgacc ttgaaggtga gacgcgcata      540

accgctagag tactttgaag aggaaacagc aatagggttg ctaccagtat aaatagacag      600

gtacatacaa cactggaaat ggttgtctgt ttgagtacgc tttcaattca tttgggtgtg      660

cactttatta tgttacaata tggaagggaa ctttacactt ctcctatgca catatattaa      720

ttaaagtcca atgctagtag agaagggggg taacacccct ccgcgctctt ttccgatttt      780

tttctaaacc gtggaatatt tcggatatcc ttttgttgtt tccgggtgta caatatggac      840

ttcctctttt ctggcaacca aacccataca tcgggattcc tataatacct tcgttggtct      900

ccctaacatg taggtggcgg aggggagata tacaatagaa cagataccag acaagacata      960

atgggctaaa caagactaca ccaattacac tgcctcattg atggtggtac ataacgaact     1020

aatactgtag ccctagactt gatagccatc atcatatcga agtttcacta ccctttttcc     1080

atttgccatc tattgaagta ataataggcg catgcaactt cttttctttt tttttctttt     1140

ctctctcccc cgttgttgtc tcaccatatc cgcaatgaca aaaaaaatga tggaagacac     1200

taaaggaaaa aattaacgac aaagacagca ccaacagatg tcgttgttcc agagctgatg     1260

aggggtatct tcgaacacac gaaacttttt ccttccttca ttcacgcaca ctactctcta     1320

atgagcaacg gtatacggcc ttccttccag ttacttgaat ttgaaataaa aaaagtttgc     1380

cgctttgcta tcaagtataa atagacctgc aattattaat cttttgtttc ctcgtcattg     1440

ttctcgttcc ctttcttcct tgtttctttt tctgcacaat atttcaagct ataccaagca     1500

tacaatcaac tccaagcttg aattaattcc gggcggaatg aaagcgttaa cggccaggca     1560

acaagaggtg tttgatctca tccgtgatca catcagccag acaggtatgc cgccgacgcg     1620

tgcggaaatc gcgcagcgtt tggggttccg ttccccaaac gcggctgaag aacatctgaa     1680

ggcgctggca cgcaaaggcg ttattgaaat tgtttccggc gcatcacgcg ggattcgtct     1740

gttgcaggaa gaggaagaag ggttgccgct ggtaggtcgt gtggctgccg gtgaaccact     1800

tctggcgcaa cagcatattg aaggtcatta tcaggtcgat ccttccttat tcaagccgaa     1860

tgctgatttc ctgctgcgcg tcagcgggat gtcgatgaaa gatatcggca ttatggatgg     1920

tgacttgctg gcagtgcata aaactcagga tgtacgtaac ggtcaggtcg ttgtcgcacg     1980

tattgatgac gaagttaccg ttaagcgcct gaaaaaacag ggcaataaag tcgaactgtt     2040

gccagaaaat agcgagttta aaccaattgt cgtagatctt cgtcagcaga gcttcaccat     2100

tgaagggctg gcggttgggg ttattcgcaa cggcgactgg ctggaattcc cggggatcct     2160

catggcggtg tcggagagcc agctcaagaa aatggtgtcc aagtacaaat acagagacct     2220

aactgtacgt gaaactgtca atgttattac tctatacaaa gatctcaaac ctgttttgga     2280

ttcatatgtt tttaacgatg gcagttccag ggaactaatg aacctcactg gaacaatccc     2340

tgtgccttat agaggtaata catacaatat tccaatatgc ctatggctac tggacacata     2400

cccatataat ccccctatct gttttgttaa gcctactagt tcaatgacta ttaaaacagg     2460

aaagcatgtt gatgcaaatg ggaagatata tcttccttat ctacatgaat ggaaacaccc     2520

acagtcagac ttgttggggc ttattcaggt catgattgtg gtatttggag atgaacctcc     2580

agtcttctct cgtcctattt cggcatccta tccgccatac caggcaacgg ggccaccaaa     2640

tacttcctac atgccaggca tgccaggtgg aatctctcca tacccatccg gataccctcc     2700

caatcccagt ggttacccag gctgtcctta cccacctggt ggtccatatc ctgccacaac     2760

aagttctcag tacccttctc agcctcctgt gaccactgtt ggtcccagta gggatggcac     2820

aatcagcgag gacaccatcc gagcctctct catctctgcg gtcagtgaca aactgagatg     2880

gcggatgaag gaggaaatgg atcgtgccca ggcagagctc aatgccttga aacgaacaga     2940

agaagacctg aaaaagggtc accagaaact ggaagagatg gttacccgtt tagatcaaga     3000

agtagccgag gttgataaaa acatagaact tttgaaaaag aaggatgaag aactcagttc     3060

tgctctggaa aaaatggaaa atcagtctga aaacaatgat atcgatgaag ttatcattcc     3120

cacagctccc ttatacaaac agatcctgaa tctgtatgca gaagaaaacg ctattgaaga     3180

cactatcctt tacttgggag aagccttgag aaggggcgtg atagacctgg atgtcttcct     3240

gaagcatgta cgtcttctgt cccgtaaaca gttccagctg agggcactaa tgcaaaaagc     3300

aagaaagact gccggtctca gtgacctcta ctgaggatcc gtcgacctgc agccaagcta     3360

attccgggcg aatttcttat gatttatgat ttttattatt aaataagtta taaaaaaaat     3420

aagtgtatac aaattttaaa gtgactctta ggttttaaaa cgaaaattct tgttcttgag     3480

taactctttc ctgtaggtca ggttgctttc tcaggtatag catgaggtcg ctcttattga     3540

ccacacctct accggcatgc cgagcaaatg cctgcaaatc gctccccatt tcacccaatt     3600

gtagatatgc taactccagc aatgagttga tgaatctcgg tgtgtatttt atgtcctcag     3660

aggacaacac ctgttgtaat cgttcttcca cacggatcga tccacaggac gggtgtggtc     3720

gccatgatcg cgtagtcgat agtggctcca agtagcgaag cgagcaggac tgggcggcgg     3780

ccaaagcggt cggacagtgc tccgagaacg ggtgcgcata gaaattgcat caacgcatat     3840

agcgctagca gcacgccata gtgactggcg atgctgtcgg aatggacgat atcccgcaag     3900

aggcccggca gtaccggcat aaccaagcct atgcctacag catccagggt gacggtgccg     3960

aggatgacga tgagcgcatt gttagatttc atacacggtg cctgactgcg ttagcaattt     4020

aactgtgata aactaccgca ttaaagctag ctttgaagaa aaatgcgcct tattcaatct     4080

ttgctataaa aaatggccca aaatctcaca ttggaagaca tttgatgacc tcatttcttt     4140

caatgaaggg cctaacggag ttgactaatg ttgtgggaaa ttggagcgat aagcgtgctt     4200

ctgccgtggc caggacaacg tatactcatc agataacagc aatacctgat cactacttcg     4260

cactagtttc tcggtactat gcatatgatc caatatcaaa ggaaatgata gcattgaagg     4320

atgagactaa tccaattgag gagtggcagc atatagaaca gctaaagggt agtgctgaag     4380

gaagcatacg ataccccgca tggaatggga taatatcaca ggaggtacta gactaccttt     4440

catcctacat aaatagacgc atataagtac gcatttaagc ataaacacgc actatgccgt     4500

tcttctcatg tatatatata tacaggcaac acgcagatat aggtgcgacg tgaacagtga     4560

gctgtatgtg cgcagctcgc gttgcatttt cggaagcgct cgttttcgga aacgctttga     4620

agttcctatt ccgaagttcc tattctctag aaagtatagg aacttcagag cgcttttgaa     4680

aaccaaaagc gctctgaaga cgcactttca aaaaaccaaa aacgcaccgg actgtaacga     4740

gctactaaaa tattgcgaat accgcttcca caaacattgc tcaaaagtat ctctttgcta     4800

tatatctctg tgctatatcc ctatataacc tacccatcca cctttcgctc cttgaacttg     4860

catctaaact cgacctctac attttttatg tttatctcta gtattactct ttagacaaaa     4920

aaattgtagt aagaactatt catagagtga atcgaaaaca atacgaaaat gtaaacattt     4980

cctatacgta gtatatagag acaaaataga agaaaccgtt cataattttc tgaccaatga     5040

agaatcatca acgctatcac tttctgttca caaagtatgc gcaatccaca tcggtataga     5100

atataatcgg ggatgccttt atcttgaaaa aatgcacccg cagcttcgct agtaatcagt     5160

aaacgcggga agtggagtca ggcttttttt atggaagaga aaatagacac caaagtagcc     5220

ttcttctaac cttaacggac ctacagtgca aaaagttatc aagagactgc attatagagc     5280

gcacaaagga gaaaaaaagt aatctaagat gctttgttag aaaaatagcg ctctcgggat     5340

gcatttttgt agaacaaaaa agaagtatag attctttgtt ggtaaaatag cgctctcgcg     5400

ttgcatttct gttctgtaaa aatgcagctc agattctttg tttgaaaaat tagcgctctc     5460

gcgttgcatt tttgttttac aaaaatgaag cacagattct tcgttggtaa aatagcgctt     5520

tcgcgttgca tttctgttct gtaaaaatgc agctcagatt ctttgtttga aaaattagcg     5580

ctctcgcgtt gcatttttgt tctacaaaat gaagcacaga tgcttcgtta acaaagatat     5640

gctattgaag tgcaagatgg aaacgcagaa aatgaaccgg ggatgcgacg tgcaagatta     5700

cctatgcaat agatgcaata gtttctccag gaaccgaaat acatacattg tcttccgtaa     5760

agcgctagac tatatattat tatacaggtt caaatatact atctgtttca gggaaaactc     5820

ccaggttcgg atgttcaaaa ttcaatgatg ggtaacaagt acgatcgtaa atctgtaaaa     5880

cagtttgtcg gatattaggc tgtatctcct caaagcgtat tcgaatatca ttgagaagct     5940

gcagcaggcg tgaagttaga cgacaacttc tctctggaaa cgcataccga tattcaggct     6000

gctgcaaagg cacaggctag tgcccgtgcg agtgcatccg gtaccacccc agatgctgta     6060

gtagcttctg gtagcactgc aatgagccat gcttatcaag aaaacacagg ttttggtact     6120

cgtcccatat atcttgacat gcaagccact acaccaacag accctagggt tttggatacg     6180

atgttgaagt tttatacggg actttatggt aatcctcatt ccaacactca ctcttacggt     6240

tgggaaacaa atactgctgt ggaaaatgct agagctcacg tagcaaagat gatcaatgcc     6300

gaccccaagg aaataatatt cacttcggga gcgaccgaat ctaataatat ggttcttaag     6360

ggtgtcccaa gattttataa gaagactaag aaacacatca tcaccactag aacggaacac     6420

aagtgtgtct tggaagccgc acgggccatg atgaaggagg gatttgaagt cactttccta     6480

aatgtggacg atcaaggtct tatcgatttg aaggaattgg aagatgccat tagaccagat     6540

acctgtctcg tctctgtgat ggctgtcaat aatgaaatcg gtgtcattca acctattaaa     6600

gaaattggag caatttgtag aaagaataag atcctcgggg acaccaaata tggcgatctc     6660

ggccttttcg tttcttggag ctgggacatg tttgccatcg atccatctac caccagaacg     6720

gccgttagat ctgctgccac cgttgtttcc accgaagaaa ccaccgttgc cgtaaccacc     6780

acgacggttg ttgctaaaga agctgccacc gccacggcca ccgttgtagc cgccgttgtt     6840

gttattgtag ttgctactgt tatttctggc acttcttggt tttcctctta agtgaggagg     6900

aacataacca ttctcgttgt tgtcgttgat gcttaaattt tgcacttgtt cgctcagttc     6960

agccataata tgaaatgctt ttcttgttgt tcttacggaa taccacttgc cacctatcac     7020

cacaactaac tttttcccgt tcctccatct cttttatatt ttttttctcg atcgagttca     7080

agagaaaaaa aaagaaaaag caaaaagaaa aaaggaaagc gcgcctcgtt cagaatgaca     7140

cgtatagaat gatgcattac cttgtcatct tcagtatcat actgttcgta tacatactta     7200

ctgacattca taggtataca tatatacaca tgtatatata tcgtatgctg cagctttaaa     7260

taatcggtgt cactacataa gaacaccttt ggtggaggga acatcgttgg taccattggg     7320

cgaggtggct tctcttatgg caaccgcaag agccttgaac gcactctcac tacggtgatg     7380

atcattcttg cctcgcagac aatcaacgtg gagggtaatt ctgctagcct ctgcaaagct     7440

ttcaagaaaa tgcgggatca tctcgcaaga gagatctcct actttctccc tttgcaaacc     7500

aagttcgaca actgcgtacg gcctgttcga aagatctacc accgctctgg aaagtgcctc     7560

atccaaaggc gcaaatcctg atccaaacct ttttactcca cgcgccagta gggcctcttt     7620

aaaagcttga ccgagagcaa tcccgcagtc ttcagtggtg tgatggtcgt ctatgtgtaa     7680

gtcaccaatg cactcaacga ttagcgacca gccggaatgc ttggccagag catgtatcat     7740

atggtccaga aaccctatac ctgtgtggac gttaatcact tgcgattgtg tggcctgttc     7800

tgctactgct tctgcctctt tttctgggaa gatcgagtgc tctatcgcta ggggaccacc     7860

ctttaaagag atcgcaatct gaatcttggt ttcatttgta atacgcttta ctagggcttt     7920

ctgctctgtc atctttgcct tcgtttatct tgcctgctca ttttttagta tattcttcga     7980

agaaatcaca ttactttata taatgtataa ttcattatgt gataatgcca atcgctaaga     8040

aaaaaaaaga gtcatccgct aggtggaaaa aaaaaaatga aaatcattac cgaggcataa     8100

aaaaatatag agtgtactag aggaggccaa gagtaataga aaaagaaaat tgcgggaaag     8160

gactgtgtta tgacttccct gactaatgcc gtgttcaaac gatacctggc agtgactcct     8220

agcgctcacc aagctcttaa aacgagaatt aagaaaaagt cgtcatcttt cgataagttt     8280

ttcccacagc aaagcaatag tagaaaaaca atgggaaacg ttgaatgaag acaaagcgtc     8340

gtggtttaaa aggaaatacg ctcacgtaca tgctagggaa caggaccgtg cagcggatct     8400

aatgaatcca tttgttagtt aatagtttaa atgtttttat cggaagaggt tttgtcatca     8460

catcagcaat gttcttcttg gtctcgatgt agtatacgta taaattatta cctgatactt     8520

catctctaag tctcattgcc tttgtgccaa aaaatctgtt tctaaatttc tcttcatttg     8580

tagacttaat tatactgatc gttgatctac tatcagtaag taagccttta aaaaaaaaaa     8640

aaaaaaaaaa aaaaaaaaaa cctgtaacaa tagcaatacc ccaaatacct aatgtagttc     8700

cagcaagcaa gctaaaaagt aaagcaacaa cataactcac ccctgcatct gcagcttttg     8760

cccgggcagc ctgctctgcc tgtgttttct ttaattgagc agtagaccat ttagcagttg     8820

catgaatagc tgcagcgtca catcggataa taatgatggc agccattgta gaagtgcctt     8880

ttgcatttct agtctctttc tcggtctagc tagttttact acatcgcgaa gatagaatct     8940

tagatcacac tgcctttgct gagctggatc aatagagtaa caaaagagtg gtaaggcctc     9000

gttaaaggac aaggacctga gcggaagtgt atcgtacagt agacggagta tactagtata     9060

gtctatagtc cgtggaatta attcttgaag acgaaagggc ctcgtgatac gcctattttt     9120

ataggttaat gtcatgataa taatggtttc ttagacgtca ggtggcactt ttcggggaaa     9180

tgtgcgcgga acccctattt gtttattttt ctaaatacat tcaaatatgt atccgctcat     9240

gagacaataa ccctgataaa tgcttcaata atattgaaaa aggaagagta tgagtattca     9300

acatttccgt gtcgccctta ttcccttttt tgcggcattt tgccttcctg tttttgctca     9360

cccagaaacg ctggtgaaag taaaagatgc tgaagatcag ttgggtgcac gagtgggtta     9420

catcgaactg gatctcaaca gcggtaagat ccttgagagt tttcgccccg aagaacgttt     9480

tccaatgatg agcactttta aagttctgct atgtggcgcg gtattatccc gtgttgacgc     9540

cgggcaagag caactcggtc gccgcataca ctattctcag aatgacttgg ttgagtactc     9600

accagtcaca gaaaagcatc ttacggatgg catgacagta agagaattat gcagtgctgc     9660

cataaccatg agtgataaca ctgcggccaa cttacttctg acaacgatcg gaggaccgaa     9720

ggagctaacc gcttttttgc acaacatggg ggatcatgta actcgccttg atcgttggga     9780

accggagctg aatgaagcca taccaaacga cgagcgtgac accacgatgc ctgcagcaat     9840

ggcaacaacg ttgcgcaaac tattaactgg cgaactactt actctagctt cccggcaaca     9900

attaatagac tggatggagg cggataaagt tgcaggacca cttctgcgct cggcccttcc     9960

ggctggctgg tttattgctg ataaatctgg agccggtgag cgtgggtctc gcggtatcat    10020

tgcagcactg gggccagatg gtaagccctc ccgtatcgta gttatctaca cgacggggag    10080

tcaggcaact atggatgaac gaaatagaca gatcgctgag ataggtgcct cactgattaa    10140

gcattggtaa ctgtcagacc aagtttactc atatatactt tagattgatt taaaacttca    10200

tttttaattt aaaaggatct aggtgaagat cctttttgat aatctcatga ccaaaatccc    10260

ttaacgtgag ttttcgttcc actgagcgtc agaccccgta gaaaagatca aaggatcttc    10320

ttgagatcct ttttttctgc gcgtaatctg ctgcttgcaa acaaaaaaac caccgctacc    10380

agcggtggtt tgtttgccgg atcaagagct accaactctt tttccgaagg taactggctt    10440

cagcagagcg cagataccaa atactgtcct tctagtgtag ccgtagttag gccaccactt    10500

caagaactct gtagcaccgc ctacatacct cgctctgcta atcctgttac cagtggctgc    10560

tgccagtggc gataagtcgt gtcttaccgg gttggactca agacgatagt taccggataa    10620

ggcgcagcgg tcgggctgaa cggggggttc gtgcacacag cccagcttgg agcgaacgac    10680

ctacaccgaa ctgagatacc tacagcgtga gctatgagaa agcgccacgc ttcccgaagg    10740

gagaaaggcg gacaggtatc cggtaagcgg cagggtcgga acaggagagc gcacgaggga    10800

gcttccaggg ggaaacgcct ggtatcttta tagtcctgtc gggtttcgcc acctctgact    10860

tgagcgtcga tttttgtgat gctcgtcagg ggggcggagc ctatggaaaa acgccagcaa    10920

cgcggccttt ttacggttcc tggccttttg ctggcctttt gctcacatgt tctttcctgc    10980

gttatcccct gattctgtgg ataaccgtat taccgccttt gagtgagctg ataccgctcg    11040

ccgcagccga acgaccgagc gcagcgagtc agtgagcgag gaagcggaag agcgcctgat    11100

gcggtatttt ctccttacgc atctgtgcgg tatttcacac cgcatatggt gcactctcag    11160

tacaatctgc tctgatgccg catagttaag ccagtataca ctccgctatc gctacgtgac    11220

tgggtcatgg ctgcgccccg acacccgcca acacccgctg acgcgccctg acgggcttgt    11280

ctgctcccgg catccgctta cagacaagct gtgaccgtct ccggg                    11325


<210>  34
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Cebador OV310

<400>  34
gggatcctca tggcggtgtc ggagagccag c                                      31


<210>  35
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Cebador OV311

<400>  35
gggatcctca gtagaggtca ctgagaccgg c                                      31


<210>  36
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Cebador OV713

<400>  36
gcgaggcata tttatggtga agg                                               23


<210>  37
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Cebador OV714

<400>  37
catttccgtg caaaggtact aac                                               23


<210>  38
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Cebador OV731

<400>  38
ctgtatataa aaccagtggt tatatgtac                                         29


<210>  39
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Cebador OV732

<400>  39
tcgagtgctc tatcgctagg g                                                 21


<210>  40
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Cebador OV715

<400>  40
ccataggatg ataatgcgat tag                                               23


<210>  41
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Cebador OV741

<400>  41
cgcttctggt gccggaaacc                                                   20


<210>  42
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Cebador OV508

<400>  42
cagattgtac tgagagtgca cc                                                22


<210>  43
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Cebador OV747

<400>  43
attccttgct tcttgttact gg                                                22


<210>  44
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Cebador OV621

<400>  44
cactgtcacc tggttggacg g                                                 21


<210>  45
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Cebador OV622

<400>  45
ctatagatca gaggttacat ggc                                               23


<210>  46
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Cebador OV284

<400>  46
cgatgatgaa gataccccac c                                                 21


<210>  47
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Cebador OV285

<400>  47
gagatggtgc acgatgcaca g                                                 21


<210>  48
<211>  1797
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Secuencia nucleotdica que codifica para la protena de fusin 
       LexA-TSG101


<220>
<221>  CDS
<222>  (1)..(1797)

<400>  48
atg aaa gcg tta acg gcc agg caa caa gag gtg ttt gat ctc atc cgt         48
Met Lys Ala Leu Thr Ala Arg Gln Gln Glu Val Phe Asp Leu Ile Arg           
1               5                   10                  15                

gat cac atc agc cag aca ggt atg ccg ccg acg cgt gcg gaa atc gcg         96
Asp His Ile Ser Gln Thr Gly Met Pro Pro Thr Arg Ala Glu Ile Ala           
            20                  25                  30                    

cag cgt ttg ggg ttc cgt tcc cca aac gcg gct gaa gaa cat ctg aag        144
Gln Arg Leu Gly Phe Arg Ser Pro Asn Ala Ala Glu Glu His Leu Lys           
        35                  40                  45                        

gcg ctg gca cgc aaa ggc gtt att gaa att gtt tcc ggc gca tca cgc        192
Ala Leu Ala Arg Lys Gly Val Ile Glu Ile Val Ser Gly Ala Ser Arg           
    50                  55                  60                            

ggg att cgt ctg ttg cag gaa gag gaa gaa ggg ttg ccg ctg gta ggt        240
Gly Ile Arg Leu Leu Gln Glu Glu Glu Glu Gly Leu Pro Leu Val Gly           
65                  70                  75                  80            

cgt gtg gct gcc ggt gaa cca ctt ctg gcg caa cag cat att gaa ggt        288
Arg Val Ala Ala Gly Glu Pro Leu Leu Ala Gln Gln His Ile Glu Gly           
                85                  90                  95                

cat tat cag gtc gat cct tcc tta ttc aag ccg aat gct gat ttc ctg        336
His Tyr Gln Val Asp Pro Ser Leu Phe Lys Pro Asn Ala Asp Phe Leu           
            100                 105                 110                   

ctg cgc gtc agc ggg atg tcg atg aaa gat atc ggc att atg gat ggt        384
Leu Arg Val Ser Gly Met Ser Met Lys Asp Ile Gly Ile Met Asp Gly           
        115                 120                 125                       

gac ttg ctg gca gtg cat aaa act cag gat gta cgt aac ggt cag gtc        432
Asp Leu Leu Ala Val His Lys Thr Gln Asp Val Arg Asn Gly Gln Val           
    130                 135                 140                           

gtt gtc gca cgt att gat gac gaa gtt acc gtt aag cgc ctg aaa aaa        480
Val Val Ala Arg Ile Asp Asp Glu Val Thr Val Lys Arg Leu Lys Lys           
145                 150                 155                 160           

cag ggc aat aaa gtc gaa ctg ttg cca gaa aat agc gag ttt aaa cca        528
Gln Gly Asn Lys Val Glu Leu Leu Pro Glu Asn Ser Glu Phe Lys Pro           
                165                 170                 175               

att gtc gta gat ctt cgt cag cag agc ttc acc att gaa ggg ctg gcg        576
Ile Val Val Asp Leu Arg Gln Gln Ser Phe Thr Ile Glu Gly Leu Ala           
            180                 185                 190                   

gtt ggg gtt att cgc aac ggc gac tgg ctg gaa ttc ccg ggg atc ctc        624
Val Gly Val Ile Arg Asn Gly Asp Trp Leu Glu Phe Pro Gly Ile Leu           
        195                 200                 205                       

atg gcg gtg tcg gag agc cag ctc aag aaa atg gtg tcc aag tac aaa        672
Met Ala Val Ser Glu Ser Gln Leu Lys Lys Met Val Ser Lys Tyr Lys           
    210                 215                 220                           

tac aga gac cta act gta cgt gaa act gtc aat gtt att act cta tac        720
Tyr Arg Asp Leu Thr Val Arg Glu Thr Val Asn Val Ile Thr Leu Tyr           
225                 230                 235                 240           

aaa gat ctc aaa cct gtt ttg gat tca tat gtt ttt aac gat ggc agt        768
Lys Asp Leu Lys Pro Val Leu Asp Ser Tyr Val Phe Asn Asp Gly Ser           
                245                 250                 255               

tcc agg gaa cta atg aac ctc act gga aca atc cct gtg cct tat aga        816
Ser Arg Glu Leu Met Asn Leu Thr Gly Thr Ile Pro Val Pro Tyr Arg           
            260                 265                 270                   

ggt aat aca tac aat att cca ata tgc cta tgg cta ctg gac aca tac        864
Gly Asn Thr Tyr Asn Ile Pro Ile Cys Leu Trp Leu Leu Asp Thr Tyr           
        275                 280                 285                       

cca tat aat ccc cct atc tgt ttt gtt aag cct act agt tca atg act        912
Pro Tyr Asn Pro Pro Ile Cys Phe Val Lys Pro Thr Ser Ser Met Thr           
    290                 295                 300                           

att aaa aca gga aag cat gtt gat gca aat ggg aag ata tat ctt cct        960
Ile Lys Thr Gly Lys His Val Asp Ala Asn Gly Lys Ile Tyr Leu Pro           
305                 310                 315                 320           

tat cta cat gaa tgg aaa cac cca cag tca gac ttg ttg ggg ctt att       1008
Tyr Leu His Glu Trp Lys His Pro Gln Ser Asp Leu Leu Gly Leu Ile           
                325                 330                 335               

cag gtc atg att gtg gta ttt gga gat gaa cct cca gtc ttc tct cgt       1056
Gln Val Met Ile Val Val Phe Gly Asp Glu Pro Pro Val Phe Ser Arg           
            340                 345                 350                   

cct att tcg gca tcc tat ccg cca tac cag gca acg ggg cca cca aat       1104
Pro Ile Ser Ala Ser Tyr Pro Pro Tyr Gln Ala Thr Gly Pro Pro Asn           
        355                 360                 365                       

act tcc tac atg cca ggc atg cca ggt gga atc tct cca tac cca tcc       1152
Thr Ser Tyr Met Pro Gly Met Pro Gly Gly Ile Ser Pro Tyr Pro Ser           
    370                 375                 380                           

gga tac cct ccc aat ccc agt ggt tac cca ggc tgt cct tac cca cct       1200
Gly Tyr Pro Pro Asn Pro Ser Gly Tyr Pro Gly Cys Pro Tyr Pro Pro           
385                 390                 395                 400           

ggt ggt cca tat cct gcc aca aca agt tct cag tac cct tct cag cct       1248
Gly Gly Pro Tyr Pro Ala Thr Thr Ser Ser Gln Tyr Pro Ser Gln Pro           
                405                 410                 415               

cct gtg acc act gtt ggt ccc agt agg gat ggc aca atc agc gag gac       1296
Pro Val Thr Thr Val Gly Pro Ser Arg Asp Gly Thr Ile Ser Glu Asp           
            420                 425                 430                   

acc atc cga gcc tct ctc atc tct gcg gtc agt gac aaa ctg aga tgg       1344
Thr Ile Arg Ala Ser Leu Ile Ser Ala Val Ser Asp Lys Leu Arg Trp           
        435                 440                 445                       

cgg atg aag gag gaa atg gat cgt gcc cag gca gag ctc aat gcc ttg       1392
Arg Met Lys Glu Glu Met Asp Arg Ala Gln Ala Glu Leu Asn Ala Leu           
    450                 455                 460                           

aaa cga aca gaa gaa gac ctg aaa aag ggt cac cag aaa ctg gaa gag       1440
Lys Arg Thr Glu Glu Asp Leu Lys Lys Gly His Gln Lys Leu Glu Glu           
465                 470                 475                 480           

atg gtt acc cgt tta gat caa gaa gta gcc gag gtt gat aaa aac ata       1488
Met Val Thr Arg Leu Asp Gln Glu Val Ala Glu Val Asp Lys Asn Ile           
                485                 490                 495               

gaa ctt ttg aaa aag aag gat gaa gaa ctc agt tct gct ctg gaa aaa       1536
Glu Leu Leu Lys Lys Lys Asp Glu Glu Leu Ser Ser Ala Leu Glu Lys           
            500                 505                 510                   

atg gaa aat cag tct gaa aac aat gat atc gat gaa gtt atc att ccc       1584
Met Glu Asn Gln Ser Glu Asn Asn Asp Ile Asp Glu Val Ile Ile Pro           
        515                 520                 525                       

aca gct ccc tta tac aaa cag atc ctg aat ctg tat gca gaa gaa aac       1632
Thr Ala Pro Leu Tyr Lys Gln Ile Leu Asn Leu Tyr Ala Glu Glu Asn           
    530                 535                 540                           

gct att gaa gac act atc ctt tac ttg gga gaa gcc ttg aga agg ggc       1680
Ala Ile Glu Asp Thr Ile Leu Tyr Leu Gly Glu Ala Leu Arg Arg Gly           
545                 550                 555                 560           

gtg ata gac ctg gat gtc ttc ctg aag cat gta cgt ctt ctg tcc cgt       1728
Val Ile Asp Leu Asp Val Phe Leu Lys His Val Arg Leu Leu Ser Arg           
                565                 570                 575               

aaa cag ttc cag ctg agg gca cta atg caa aaa gca aga aag act gcc       1776
Lys Gln Phe Gln Leu Arg Ala Leu Met Gln Lys Ala Arg Lys Thr Ala           
            580                 585                 590                   

ggt ctc agt gac ctc tac tga                                           1797
Gly Leu Ser Asp Leu Tyr                                                   
        595                                                               


<210>  49
<211>  598
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  49

Met Lys Ala Leu Thr Ala Arg Gln Gln Glu Val Phe Asp Leu Ile Arg 
1               5                   10                  15      


Asp His Ile Ser Gln Thr Gly Met Pro Pro Thr Arg Ala Glu Ile Ala 
            20                  25                  30          


Gln Arg Leu Gly Phe Arg Ser Pro Asn Ala Ala Glu Glu His Leu Lys 
        35                  40                  45              


Ala Leu Ala Arg Lys Gly Val Ile Glu Ile Val Ser Gly Ala Ser Arg 
    50                  55                  60                  


Gly Ile Arg Leu Leu Gln Glu Glu Glu Glu Gly Leu Pro Leu Val Gly 
65                  70                  75                  80  


Arg Val Ala Ala Gly Glu Pro Leu Leu Ala Gln Gln His Ile Glu Gly 
                85                  90                  95      


His Tyr Gln Val Asp Pro Ser Leu Phe Lys Pro Asn Ala Asp Phe Leu 
            100                 105                 110         


Leu Arg Val Ser Gly Met Ser Met Lys Asp Ile Gly Ile Met Asp Gly 
        115                 120                 125             


Asp Leu Leu Ala Val His Lys Thr Gln Asp Val Arg Asn Gly Gln Val 
    130                 135                 140                 


Val Val Ala Arg Ile Asp Asp Glu Val Thr Val Lys Arg Leu Lys Lys 
145                 150                 155                 160 


Gln Gly Asn Lys Val Glu Leu Leu Pro Glu Asn Ser Glu Phe Lys Pro 
                165                 170                 175     


Ile Val Val Asp Leu Arg Gln Gln Ser Phe Thr Ile Glu Gly Leu Ala 
            180                 185                 190         


Val Gly Val Ile Arg Asn Gly Asp Trp Leu Glu Phe Pro Gly Ile Leu 
        195                 200                 205             


Met Ala Val Ser Glu Ser Gln Leu Lys Lys Met Val Ser Lys Tyr Lys 
    210                 215                 220                 


Tyr Arg Asp Leu Thr Val Arg Glu Thr Val Asn Val Ile Thr Leu Tyr 
225                 230                 235                 240 


Lys Asp Leu Lys Pro Val Leu Asp Ser Tyr Val Phe Asn Asp Gly Ser 
                245                 250                 255     


Ser Arg Glu Leu Met Asn Leu Thr Gly Thr Ile Pro Val Pro Tyr Arg 
            260                 265                 270         


Gly Asn Thr Tyr Asn Ile Pro Ile Cys Leu Trp Leu Leu Asp Thr Tyr 
        275                 280                 285             


Pro Tyr Asn Pro Pro Ile Cys Phe Val Lys Pro Thr Ser Ser Met Thr 
    290                 295                 300                 


Ile Lys Thr Gly Lys His Val Asp Ala Asn Gly Lys Ile Tyr Leu Pro 
305                 310                 315                 320 


Tyr Leu His Glu Trp Lys His Pro Gln Ser Asp Leu Leu Gly Leu Ile 
                325                 330                 335     


Gln Val Met Ile Val Val Phe Gly Asp Glu Pro Pro Val Phe Ser Arg 
            340                 345                 350         


Pro Ile Ser Ala Ser Tyr Pro Pro Tyr Gln Ala Thr Gly Pro Pro Asn 
        355                 360                 365             


Thr Ser Tyr Met Pro Gly Met Pro Gly Gly Ile Ser Pro Tyr Pro Ser 
    370                 375                 380                 


Gly Tyr Pro Pro Asn Pro Ser Gly Tyr Pro Gly Cys Pro Tyr Pro Pro 
385                 390                 395                 400 


Gly Gly Pro Tyr Pro Ala Thr Thr Ser Ser Gln Tyr Pro Ser Gln Pro 
                405                 410                 415     


Pro Val Thr Thr Val Gly Pro Ser Arg Asp Gly Thr Ile Ser Glu Asp 
            420                 425                 430         


Thr Ile Arg Ala Ser Leu Ile Ser Ala Val Ser Asp Lys Leu Arg Trp 
        435                 440                 445             


Arg Met Lys Glu Glu Met Asp Arg Ala Gln Ala Glu Leu Asn Ala Leu 
    450                 455                 460                 


Lys Arg Thr Glu Glu Asp Leu Lys Lys Gly His Gln Lys Leu Glu Glu 
465                 470                 475                 480 


Met Val Thr Arg Leu Asp Gln Glu Val Ala Glu Val Asp Lys Asn Ile 
                485                 490                 495     


Glu Leu Leu Lys Lys Lys Asp Glu Glu Leu Ser Ser Ala Leu Glu Lys 
            500                 505                 510         


Met Glu Asn Gln Ser Glu Asn Asn Asp Ile Asp Glu Val Ile Ile Pro 
        515                 520                 525             


Thr Ala Pro Leu Tyr Lys Gln Ile Leu Asn Leu Tyr Ala Glu Glu Asn 
    530                 535                 540                 


Ala Ile Glu Asp Thr Ile Leu Tyr Leu Gly Glu Ala Leu Arg Arg Gly 
545                 550                 555                 560 


Val Ile Asp Leu Asp Val Phe Leu Lys His Val Arg Leu Leu Ser Arg 
                565                 570                 575     


Lys Gln Phe Gln Leu Arg Ala Leu Met Gln Lys Ala Arg Lys Thr Ala 
            580                 585                 590         


Gly Leu Ser Asp Leu Tyr 
        595             


<210>  50
<211>  2421
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Secuencia nucleotdica que codifica GBD-GKRP


<220>
<221>  CDS
<222>  (1)..(2421)

<400>  50
atg aag cta ctg tct tct atc gaa caa gca tgc gat att tgc cga ctt         48
Met Lys Leu Leu Ser Ser Ile Glu Gln Ala Cys Asp Ile Cys Arg Leu           
1               5                   10                  15                

aaa aag ctc aag tgc tcc aaa gaa aaa ccg aag tgc gcc aag tgt ctg         96
Lys Lys Leu Lys Cys Ser Lys Glu Lys Pro Lys Cys Ala Lys Cys Leu           
            20                  25                  30                    

aag aac aac tgg gag tgt cgc tac tct ccc aaa acc aaa agg tct ccg        144
Lys Asn Asn Trp Glu Cys Arg Tyr Ser Pro Lys Thr Lys Arg Ser Pro           
        35                  40                  45                        

ctg act agg gca cat ctg aca gaa gtg gaa tca agg cta gaa aga ctg        192
Leu Thr Arg Ala His Leu Thr Glu Val Glu Ser Arg Leu Glu Arg Leu           
    50                  55                  60                            

gaa cag cta ttt cta ctg att ttt cct cga gaa gac ctt gac atg att        240
Glu Gln Leu Phe Leu Leu Ile Phe Pro Arg Glu Asp Leu Asp Met Ile           
65                  70                  75                  80            

ttg aaa atg gat tct tta cag gat ata aaa gca ttg tta aca gga tta        288
Leu Lys Met Asp Ser Leu Gln Asp Ile Lys Ala Leu Leu Thr Gly Leu           
                85                  90                  95                

ttt gta caa gat aat gtg aat aaa gat gcc gtc aca gat aga ttg gct        336
Phe Val Gln Asp Asn Val Asn Lys Asp Ala Val Thr Asp Arg Leu Ala           
            100                 105                 110                   

tca gtg gag act gat atg cct cta aca ttg aga cag cat aga ata agt        384
Ser Val Glu Thr Asp Met Pro Leu Thr Leu Arg Gln His Arg Ile Ser           
        115                 120                 125                       

gcg aca tca tca tcg gaa gag agt agt aac aaa ggt caa aga cag ttg        432
Ala Thr Ser Ser Ser Glu Glu Ser Ser Asn Lys Gly Gln Arg Gln Leu           
    130                 135                 140                           

act gta tcg ccg gaa ttt gta ata cga ctc act ata ggg cga gcc gcc        480
Thr Val Ser Pro Glu Phe Val Ile Arg Leu Thr Ile Gly Arg Ala Ala           
145                 150                 155                 160           

atc atg gag gag cag aag ctg atc tca gag gag gac ctg cat atg gcc        528
Ile Met Glu Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu His Met Ala           
                165                 170                 175               

atg gag gcc gaa ttc atg cca ggc aca aaa cgg ttt caa cat gtc att        576
Met Glu Ala Glu Phe Met Pro Gly Thr Lys Arg Phe Gln His Val Ile           
            180                 185                 190                   

gag acc ccg gag cct ggc aag tgg gag ttg tct ggg tac gag gca gct        624
Glu Thr Pro Glu Pro Gly Lys Trp Glu Leu Ser Gly Tyr Glu Ala Ala           
        195                 200                 205                       

gtg cca atc acg gag aag tca aac cca ctg acc cag gat cta gac aaa        672
Val Pro Ile Thr Glu Lys Ser Asn Pro Leu Thr Gln Asp Leu Asp Lys           
    210                 215                 220                           

gca gat gct gag aac att gtt cga ctg cta ggg caa tgt gat gct gag        720
Ala Asp Ala Glu Asn Ile Val Arg Leu Leu Gly Gln Cys Asp Ala Glu           
225                 230                 235                 240           

atc ttc cag gag gag ggg caa gcc ctg tcc aca tac cag aga ctc tac        768
Ile Phe Gln Glu Glu Gly Gln Ala Leu Ser Thr Tyr Gln Arg Leu Tyr           
                245                 250                 255               

agc gaa tcc att ctg acc acc atg gta cag gtg gct ggg aaa gtt cag        816
Ser Glu Ser Ile Leu Thr Thr Met Val Gln Val Ala Gly Lys Val Gln           
            260                 265                 270                   

gaa gtg ctg aag gag cca gat ggg ggg ctg gtt gtg ctg agt gga ggg        864
Glu Val Leu Lys Glu Pro Asp Gly Gly Leu Val Val Leu Ser Gly Gly           
        275                 280                 285                       

ggc acc tct ggc cgg atg gca ttc ctc atg tcg gtg tcc ttt aat cag        912
Gly Thr Ser Gly Arg Met Ala Phe Leu Met Ser Val Ser Phe Asn Gln           
    290                 295                 300                           

ctg atg aaa ggt ctg gga cag aaa cct ctt tac acc tac ctc att gca        960
Leu Met Lys Gly Leu Gly Gln Lys Pro Leu Tyr Thr Tyr Leu Ile Ala           
305                 310                 315                 320           

ggt ggt gac agg tct gtg gtg gcc tct agg gag ggg aca gaa gat agt       1008
Gly Gly Asp Arg Ser Val Val Ala Ser Arg Glu Gly Thr Glu Asp Ser           
                325                 330                 335               

gcc ttg cac ggg att gag gaa ctg aag aag gtg gct gcc ggg aag aag       1056
Ala Leu His Gly Ile Glu Glu Leu Lys Lys Val Ala Ala Gly Lys Lys           
            340                 345                 350                   

aga gtg att gtc att ggc att tct gtg gga ctc tct gct ccc ttt gtg       1104
Arg Val Ile Val Ile Gly Ile Ser Val Gly Leu Ser Ala Pro Phe Val           
        355                 360                 365                       

gca ggc cag atg gac tgc tgc atg aac aac aca gct gtc ttc ttg cca       1152
Ala Gly Gln Met Asp Cys Cys Met Asn Asn Thr Ala Val Phe Leu Pro           
    370                 375                 380                           

gtc ctg gtt ggc ttc aat cca gtg agc atg gcc aga aat gac ccc att       1200
Val Leu Val Gly Phe Asn Pro Val Ser Met Ala Arg Asn Asp Pro Ile           
385                 390                 395                 400           

gaa gac tgg agt tca aca ttc cga caa gta gca gag cgg atg cag aaa       1248
Glu Asp Trp Ser Ser Thr Phe Arg Gln Val Ala Glu Arg Met Gln Lys           
                405                 410                 415               

atg cag gag aaa cag aaa gct ttt gtg ctc aat cct gcc atc ggg ccc       1296
Met Gln Glu Lys Gln Lys Ala Phe Val Leu Asn Pro Ala Ile Gly Pro           
            420                 425                 430                   

gag ggt ctc agc ggc tcc tcc cgg atg aaa ggt gga agt gcc acc aag       1344
Glu Gly Leu Ser Gly Ser Ser Arg Met Lys Gly Gly Ser Ala Thr Lys           
        435                 440                 445                       

att ctg ctg gaa acc ctg tta tta gca gcc cat aag act gtg gac cag       1392
Ile Leu Leu Glu Thr Leu Leu Leu Ala Ala His Lys Thr Val Asp Gln           
    450                 455                 460                           

ggc att gca gca tct caa aga tgc ctc ctg gaa atc ttg cgg aca ttt       1440
Gly Ile Ala Ala Ser Gln Arg Cys Leu Leu Glu Ile Leu Arg Thr Phe           
465                 470                 475                 480           

gag cga gct cat cag gtg acc tac agc caa agc ccc aag att gcc acc       1488
Glu Arg Ala His Gln Val Thr Tyr Ser Gln Ser Pro Lys Ile Ala Thr           
                485                 490                 495               

ctg atg aag agt gtc agc acc agt ctg gag aag aaa ggc cac gtg tac       1536
Leu Met Lys Ser Val Ser Thr Ser Leu Glu Lys Lys Gly His Val Tyr           
            500                 505                 510                   

ctg gtt ggc tgg cag acc ctg ggt atc att gcc atc atg gat gga gta       1584
Leu Val Gly Trp Gln Thr Leu Gly Ile Ile Ala Ile Met Asp Gly Val           
        515                 520                 525                       

gag tgc atc cac acc ttt ggt gct gat ttc cga gat gtc cgt ggc ttt       1632
Glu Cys Ile His Thr Phe Gly Ala Asp Phe Arg Asp Val Arg Gly Phe           
    530                 535                 540                           

ctc att ggt gat cac agt gac atg ttt aac cag aag gct gag ctc acc       1680
Leu Ile Gly Asp His Ser Asp Met Phe Asn Gln Lys Ala Glu Leu Thr           
545                 550                 555                 560           

aac cag ggt ccc cag ttc acc ttc tcc cag gag gac ttc ccg act tcc       1728
Asn Gln Gly Pro Gln Phe Thr Phe Ser Gln Glu Asp Phe Pro Thr Ser           
                565                 570                 575               

atc ctt ccc tct ctc acg gaa atc gat act gtg gtc ttc att ttc acc       1776
Ile Leu Pro Ser Leu Thr Glu Ile Asp Thr Val Val Phe Ile Phe Thr           
            580                 585                 590                   

ctg gat gac aac ctc acg gag gtg cag act ata gtg gag cag gtg aaa       1824
Leu Asp Asp Asn Leu Thr Glu Val Gln Thr Ile Val Glu Gln Val Lys           
        595                 600                 605                       

gag aag acc aac cac atc cag gcc ctg gca cac agc acc gtg ggt cag       1872
Glu Lys Thr Asn His Ile Gln Ala Leu Ala His Ser Thr Val Gly Gln           
    610                 615                 620                           

acc ttg ccg atc cct ctg aag aag ctc ttt ccc tcc atc atc agc atc       1920
Thr Leu Pro Ile Pro Leu Lys Lys Leu Phe Pro Ser Ile Ile Ser Ile           
625                 630                 635                 640           

aca tgg cca ctg ctt ttc ttt gaa tat gaa ggg aac ttc atc cag aag       1968
Thr Trp Pro Leu Leu Phe Phe Glu Tyr Glu Gly Asn Phe Ile Gln Lys           
                645                 650                 655               

ttc cag cgt gag cta agc acc aaa tgg gtg ctg aat aca gtg agt aca       2016
Phe Gln Arg Glu Leu Ser Thr Lys Trp Val Leu Asn Thr Val Ser Thr           
            660                 665                 670                   

ggt gct cat gtg ctt ctt ggt aag atc cta caa aac cac atg ttg gac       2064
Gly Ala His Val Leu Leu Gly Lys Ile Leu Gln Asn His Met Leu Asp           
        675                 680                 685                       

ctt cgg att agc aac tcc aag ctc ttc tgg cgg gcg ctg gcc atg ctg       2112
Leu Arg Ile Ser Asn Ser Lys Leu Phe Trp Arg Ala Leu Ala Met Leu           
    690                 695                 700                           

cag cgg ttc tct gga cag tcc aag gct cga tgc atc gag agc ctc ctc       2160
Gln Arg Phe Ser Gly Gln Ser Lys Ala Arg Cys Ile Glu Ser Leu Leu           
705                 710                 715                 720           

cga gcg atc cac ttt ccc cag cca ctg tca gat gat att cgg gct gct       2208
Arg Ala Ile His Phe Pro Gln Pro Leu Ser Asp Asp Ile Arg Ala Ala           
                725                 730                 735               

ccc atc tcc tgc cgt gtc cag gtt gca cat gag aag gaa cag gtg ata       2256
Pro Ile Ser Cys Arg Val Gln Val Ala His Glu Lys Glu Gln Val Ile           
            740                 745                 750                   

ccc atc gcc ttg ctg agc ctc cta ttc cgg tgc tcg atc act gag gct       2304
Pro Ile Ala Leu Leu Ser Leu Leu Phe Arg Cys Ser Ile Thr Glu Ala           
        755                 760                 765                       

cag gca cac ctg gct gca gct cct tct gtc tgt gag gct gtc agg agt       2352
Gln Ala His Leu Ala Ala Ala Pro Ser Val Cys Glu Ala Val Arg Ser           
    770                 775                 780                           

gct ctt gct ggg cca ggt cag aag cgc act gcg gac ccc ctc gag atc       2400
Ala Leu Ala Gly Pro Gly Gln Lys Arg Thr Ala Asp Pro Leu Glu Ile           
785                 790                 795                 800           

cta gag cct gac gtt cag tga                                           2421
Leu Glu Pro Asp Val Gln                                                   
                805                                                       


<210>  51
<211>  806
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  51

Met Lys Leu Leu Ser Ser Ile Glu Gln Ala Cys Asp Ile Cys Arg Leu 
1               5                   10                  15      


Lys Lys Leu Lys Cys Ser Lys Glu Lys Pro Lys Cys Ala Lys Cys Leu 
            20                  25                  30          


Lys Asn Asn Trp Glu Cys Arg Tyr Ser Pro Lys Thr Lys Arg Ser Pro 
        35                  40                  45              


Leu Thr Arg Ala His Leu Thr Glu Val Glu Ser Arg Leu Glu Arg Leu 
    50                  55                  60                  


Glu Gln Leu Phe Leu Leu Ile Phe Pro Arg Glu Asp Leu Asp Met Ile 
65                  70                  75                  80  


Leu Lys Met Asp Ser Leu Gln Asp Ile Lys Ala Leu Leu Thr Gly Leu 
                85                  90                  95      


Phe Val Gln Asp Asn Val Asn Lys Asp Ala Val Thr Asp Arg Leu Ala 
            100                 105                 110         


Ser Val Glu Thr Asp Met Pro Leu Thr Leu Arg Gln His Arg Ile Ser 
        115                 120                 125             


Ala Thr Ser Ser Ser Glu Glu Ser Ser Asn Lys Gly Gln Arg Gln Leu 
    130                 135                 140                 


Thr Val Ser Pro Glu Phe Val Ile Arg Leu Thr Ile Gly Arg Ala Ala 
145                 150                 155                 160 


Ile Met Glu Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu His Met Ala 
                165                 170                 175     


Met Glu Ala Glu Phe Met Pro Gly Thr Lys Arg Phe Gln His Val Ile 
            180                 185                 190         


Glu Thr Pro Glu Pro Gly Lys Trp Glu Leu Ser Gly Tyr Glu Ala Ala 
        195                 200                 205             


Val Pro Ile Thr Glu Lys Ser Asn Pro Leu Thr Gln Asp Leu Asp Lys 
    210                 215                 220                 


Ala Asp Ala Glu Asn Ile Val Arg Leu Leu Gly Gln Cys Asp Ala Glu 
225                 230                 235                 240 


Ile Phe Gln Glu Glu Gly Gln Ala Leu Ser Thr Tyr Gln Arg Leu Tyr 
                245                 250                 255     


Ser Glu Ser Ile Leu Thr Thr Met Val Gln Val Ala Gly Lys Val Gln 
            260                 265                 270         


Glu Val Leu Lys Glu Pro Asp Gly Gly Leu Val Val Leu Ser Gly Gly 
        275                 280                 285             


Gly Thr Ser Gly Arg Met Ala Phe Leu Met Ser Val Ser Phe Asn Gln 
    290                 295                 300                 


Leu Met Lys Gly Leu Gly Gln Lys Pro Leu Tyr Thr Tyr Leu Ile Ala 
305                 310                 315                 320 


Gly Gly Asp Arg Ser Val Val Ala Ser Arg Glu Gly Thr Glu Asp Ser 
                325                 330                 335     


Ala Leu His Gly Ile Glu Glu Leu Lys Lys Val Ala Ala Gly Lys Lys 
            340                 345                 350         


Arg Val Ile Val Ile Gly Ile Ser Val Gly Leu Ser Ala Pro Phe Val 
        355                 360                 365             


Ala Gly Gln Met Asp Cys Cys Met Asn Asn Thr Ala Val Phe Leu Pro 
    370                 375                 380                 


Val Leu Val Gly Phe Asn Pro Val Ser Met Ala Arg Asn Asp Pro Ile 
385                 390                 395                 400 


Glu Asp Trp Ser Ser Thr Phe Arg Gln Val Ala Glu Arg Met Gln Lys 
                405                 410                 415     


Met Gln Glu Lys Gln Lys Ala Phe Val Leu Asn Pro Ala Ile Gly Pro 
            420                 425                 430         


Glu Gly Leu Ser Gly Ser Ser Arg Met Lys Gly Gly Ser Ala Thr Lys 
        435                 440                 445             


Ile Leu Leu Glu Thr Leu Leu Leu Ala Ala His Lys Thr Val Asp Gln 
    450                 455                 460                 


Gly Ile Ala Ala Ser Gln Arg Cys Leu Leu Glu Ile Leu Arg Thr Phe 
465                 470                 475                 480 


Glu Arg Ala His Gln Val Thr Tyr Ser Gln Ser Pro Lys Ile Ala Thr 
                485                 490                 495     


Leu Met Lys Ser Val Ser Thr Ser Leu Glu Lys Lys Gly His Val Tyr 
            500                 505                 510         


Leu Val Gly Trp Gln Thr Leu Gly Ile Ile Ala Ile Met Asp Gly Val 
        515                 520                 525             


Glu Cys Ile His Thr Phe Gly Ala Asp Phe Arg Asp Val Arg Gly Phe 
    530                 535                 540                 


Leu Ile Gly Asp His Ser Asp Met Phe Asn Gln Lys Ala Glu Leu Thr 
545                 550                 555                 560 


Asn Gln Gly Pro Gln Phe Thr Phe Ser Gln Glu Asp Phe Pro Thr Ser 
                565                 570                 575     


Ile Leu Pro Ser Leu Thr Glu Ile Asp Thr Val Val Phe Ile Phe Thr 
            580                 585                 590         


Leu Asp Asp Asn Leu Thr Glu Val Gln Thr Ile Val Glu Gln Val Lys 
        595                 600                 605             


Glu Lys Thr Asn His Ile Gln Ala Leu Ala His Ser Thr Val Gly Gln 
    610                 615                 620                 


Thr Leu Pro Ile Pro Leu Lys Lys Leu Phe Pro Ser Ile Ile Ser Ile 
625                 630                 635                 640 


Thr Trp Pro Leu Leu Phe Phe Glu Tyr Glu Gly Asn Phe Ile Gln Lys 
                645                 650                 655     


Phe Gln Arg Glu Leu Ser Thr Lys Trp Val Leu Asn Thr Val Ser Thr 
            660                 665                 670         


Gly Ala His Val Leu Leu Gly Lys Ile Leu Gln Asn His Met Leu Asp 
        675                 680                 685             


Leu Arg Ile Ser Asn Ser Lys Leu Phe Trp Arg Ala Leu Ala Met Leu 
    690                 695                 700                 


Gln Arg Phe Ser Gly Gln Ser Lys Ala Arg Cys Ile Glu Ser Leu Leu 
705                 710                 715                 720 


Arg Ala Ile His Phe Pro Gln Pro Leu Ser Asp Asp Ile Arg Ala Ala 
                725                 730                 735     


Pro Ile Ser Cys Arg Val Gln Val Ala His Glu Lys Glu Gln Val Ile 
            740                 745                 750         


Pro Ile Ala Leu Leu Ser Leu Leu Phe Arg Cys Ser Ile Thr Glu Ala 
        755                 760                 765             


Gln Ala His Leu Ala Ala Ala Pro Ser Val Cys Glu Ala Val Arg Ser 
    770                 775                 780                 


Ala Leu Ala Gly Pro Gly Gln Lys Arg Thr Ala Asp Pro Leu Glu Ile 
785                 790                 795                 800 


Leu Glu Pro Asp Val Gln 
                805     


<210>  52
<211>  1974
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Secuencia nucleotdica que codifica para GAD-GK-3xPTAP


<220>
<221>  CDS
<222>  (1)..(1974)

<400>  52
atg gat aaa gcg gaa tta att ccc gag cct cca aaa aag aag aga aag         48
Met Asp Lys Ala Glu Leu Ile Pro Glu Pro Pro Lys Lys Lys Arg Lys           
1               5                   10                  15                

gtc gaa ttg ggt acc gcc gcc aat ttt aat caa agt ggg aat att gct         96
Val Glu Leu Gly Thr Ala Ala Asn Phe Asn Gln Ser Gly Asn Ile Ala           
            20                  25                  30                    

gat agc tca ttg tcc ttc act ttc act aac agt agc aac ggt ccg aac        144
Asp Ser Ser Leu Ser Phe Thr Phe Thr Asn Ser Ser Asn Gly Pro Asn           
        35                  40                  45                        

ctc ata aca act caa aca aat tct caa gcg ctt tca caa cca att gcc        192
Leu Ile Thr Thr Gln Thr Asn Ser Gln Ala Leu Ser Gln Pro Ile Ala           
    50                  55                  60                            

tcc tct aac gtt cat gat aac ttc atg aat aat gaa atc acg gct agt        240
Ser Ser Asn Val His Asp Asn Phe Met Asn Asn Glu Ile Thr Ala Ser           
65                  70                  75                  80            

aaa att gat gat ggt aat aat tca aaa cca ctg tca cct ggt tgg acg        288
Lys Ile Asp Asp Gly Asn Asn Ser Lys Pro Leu Ser Pro Gly Trp Thr           
                85                  90                  95                

gac caa act gcg tat aac gcg ttt gga atc act aca ggg atg ttt aat        336
Asp Gln Thr Ala Tyr Asn Ala Phe Gly Ile Thr Thr Gly Met Phe Asn           
            100                 105                 110                   

acc act aca atg gat gat gta tat aac tat cta ttc gat gat gaa gat        384
Thr Thr Thr Met Asp Asp Val Tyr Asn Tyr Leu Phe Asp Asp Glu Asp           
        115                 120                 125                       

acc cca cca aac cca aaa aaa gag atc tgt atg gct tac cca tac gat        432
Thr Pro Pro Asn Pro Lys Lys Glu Ile Cys Met Ala Tyr Pro Tyr Asp           
    130                 135                 140                           

gtt cca gat tac gct agc ttg ggt ggt cat atg gcc atg gag gcc ccg        480
Val Pro Asp Tyr Ala Ser Leu Gly Gly His Met Ala Met Glu Ala Pro           
145                 150                 155                 160           

ggg atc ctg atg ctg gac gac aga gcc agg atg gag gcc gcc aag aag        528
Gly Ile Leu Met Leu Asp Asp Arg Ala Arg Met Glu Ala Ala Lys Lys           
                165                 170                 175               

gag aag gta gag cag atc ctg gca gag ttc cag ctg cag gag gag gac        576
Glu Lys Val Glu Gln Ile Leu Ala Glu Phe Gln Leu Gln Glu Glu Asp           
            180                 185                 190                   

ctg aag aag gtg atg aga cgg atg cag aag gag atg gac cgc ggc ctg        624
Leu Lys Lys Val Met Arg Arg Met Gln Lys Glu Met Asp Arg Gly Leu           
        195                 200                 205                       

agg ctg gag acc cat gaa gag gcc agt gtg aag atg ctg ccc acc tac        672
Arg Leu Glu Thr His Glu Glu Ala Ser Val Lys Met Leu Pro Thr Tyr           
    210                 215                 220                           

gtg cgc tcc acc cca gaa ggc tca gaa gtc ggg gac ttc ctc tcc ctg        720
Val Arg Ser Thr Pro Glu Gly Ser Glu Val Gly Asp Phe Leu Ser Leu           
225                 230                 235                 240           

gac ctg ggt ggc act aac ttc agg gtg atg ctg gtg aag gtg gga gaa        768
Asp Leu Gly Gly Thr Asn Phe Arg Val Met Leu Val Lys Val Gly Glu           
                245                 250                 255               

ggt gag gag ggg cag tgg agc gtg aag acc aaa cac cag atg tac tcc        816
Gly Glu Glu Gly Gln Trp Ser Val Lys Thr Lys His Gln Met Tyr Ser           
            260                 265                 270                   

atc ccc gag gac gcc atg acc ggc act gct gag atg ctc ttc gac tac        864
Ile Pro Glu Asp Ala Met Thr Gly Thr Ala Glu Met Leu Phe Asp Tyr           
        275                 280                 285                       

atc tct gag tgc atc tcc gac ttc ctg gac aag cat cag atg aaa cac        912
Ile Ser Glu Cys Ile Ser Asp Phe Leu Asp Lys His Gln Met Lys His           
    290                 295                 300                           

aag aag ctg ccc ctg ggc ttc acc ttc tcc ttt cct gtg agg cac gaa        960
Lys Lys Leu Pro Leu Gly Phe Thr Phe Ser Phe Pro Val Arg His Glu           
305                 310                 315                 320           

gac atc gat aag ggc atc ctt ctc aac tgg acc aag ggc ttc aag gcc       1008
Asp Ile Asp Lys Gly Ile Leu Leu Asn Trp Thr Lys Gly Phe Lys Ala           
                325                 330                 335               

tca gga gca gaa ggg aac aat gtc gtg ggg ctt ctg cga gac gct atc       1056
Ser Gly Ala Glu Gly Asn Asn Val Val Gly Leu Leu Arg Asp Ala Ile           
            340                 345                 350                   

aaa cgg aga ggg gac ttt gaa atg gat gtg gtg gca atg gtg aat gac       1104
Lys Arg Arg Gly Asp Phe Glu Met Asp Val Val Ala Met Val Asn Asp           
        355                 360                 365                       

acg gtg gcc acg atg atc tcc tgc tac tac gaa gac cat cag tgc gag       1152
Thr Val Ala Thr Met Ile Ser Cys Tyr Tyr Glu Asp His Gln Cys Glu           
    370                 375                 380                           

gtc ggc atg atc gtg ggc acg ggc tgc aat gcc tgc tac atg gag gag       1200
Val Gly Met Ile Val Gly Thr Gly Cys Asn Ala Cys Tyr Met Glu Glu           
385                 390                 395                 400           

atg cag aat gtg gag ctg gtg gag ggg gac gag ggc cgc atg tgc gtc       1248
Met Gln Asn Val Glu Leu Val Glu Gly Asp Glu Gly Arg Met Cys Val           
                405                 410                 415               

aat acc gag tgg ggc gcc ttc ggg gac tcc ggc gag ctg gac gag ttc       1296
Asn Thr Glu Trp Gly Ala Phe Gly Asp Ser Gly Glu Leu Asp Glu Phe           
            420                 425                 430                   

ctg ctg gag tat gac cgc ctg gtg gac gag agc tct gca aac ccc ggt       1344
Leu Leu Glu Tyr Asp Arg Leu Val Asp Glu Ser Ser Ala Asn Pro Gly           
        435                 440                 445                       

cag cag ctg tat gag aag ctc ata ggt ggc aag tac atg ggc gag ctg       1392
Gln Gln Leu Tyr Glu Lys Leu Ile Gly Gly Lys Tyr Met Gly Glu Leu           
    450                 455                 460                           

gtg cgg ctt gtg ctg ctc agg ctc gtg gac gaa aac ctg ctc ttc cac       1440
Val Arg Leu Val Leu Leu Arg Leu Val Asp Glu Asn Leu Leu Phe His           
465                 470                 475                 480           

ggg gag gcc tcc gag cag ctg cgc aca cgc gga gcc ttc gag acg cgc       1488
Gly Glu Ala Ser Glu Gln Leu Arg Thr Arg Gly Ala Phe Glu Thr Arg           
                485                 490                 495               

ttc gtg tcg cag gtg gag agc gac acg ggc gac cgc aag cag atc tac       1536
Phe Val Ser Gln Val Glu Ser Asp Thr Gly Asp Arg Lys Gln Ile Tyr           
            500                 505                 510                   

aac atc ctg agc acg ctg ggg ctg cga ccc tcg acc acc gac tgc gac       1584
Asn Ile Leu Ser Thr Leu Gly Leu Arg Pro Ser Thr Thr Asp Cys Asp           
        515                 520                 525                       

atc gtg cgc cgc gcc tgc gag agc gtg tct acg cgc gct gcg cac atg       1632
Ile Val Arg Arg Ala Cys Glu Ser Val Ser Thr Arg Ala Ala His Met           
    530                 535                 540                           

tgc tcg gcg ggg ctg gcg ggc gtc atc aac cgc atg cgc gag agc cgc       1680
Cys Ser Ala Gly Leu Ala Gly Val Ile Asn Arg Met Arg Glu Ser Arg           
545                 550                 555                 560           

agc gag gac gta atg cgc atc act gtg ggc gtg gat ggc tcc gtg tac       1728
Ser Glu Asp Val Met Arg Ile Thr Val Gly Val Asp Gly Ser Val Tyr           
                565                 570                 575               

aag ctg cac ccc agc ttc aag gag cgg ttc cat gcc agc gtg cgc agg       1776
Lys Leu His Pro Ser Phe Lys Glu Arg Phe His Ala Ser Val Arg Arg           
            580                 585                 590                   

ctg acg ccc agc tgc gag atc acc ttc atc gag tcg gag gag ggc agt       1824
Leu Thr Pro Ser Cys Glu Ile Thr Phe Ile Glu Ser Glu Glu Gly Ser           
        595                 600                 605                       

ggc cgg ggc gcg gcc ctg gtc tcg gcg gtg gcc tgt aag aag gcc tgt       1872
Gly Arg Gly Ala Ala Leu Val Ser Ala Val Ala Cys Lys Lys Ala Cys           
    610                 615                 620                           

atg ctg ggc cag tgg atc cga att cga gct cga gag cca gaa ccc aca       1920
Met Leu Gly Gln Trp Ile Arg Ile Arg Ala Arg Glu Pro Glu Pro Thr           
625                 630                 635                 640           

gca ccg cct gag cct acc gcc cca ccc gaa ccg acg gcg cct cca gct       1968
Ala Pro Pro Glu Pro Thr Ala Pro Pro Glu Pro Thr Ala Pro Pro Ala           
                645                 650                 655               

gag taa                                                               1974
Glu                                                                       
                                                                          


<210>  53
<211>  657
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  53

Met Asp Lys Ala Glu Leu Ile Pro Glu Pro Pro Lys Lys Lys Arg Lys 
1               5                   10                  15      


Val Glu Leu Gly Thr Ala Ala Asn Phe Asn Gln Ser Gly Asn Ile Ala 
            20                  25                  30          


Asp Ser Ser Leu Ser Phe Thr Phe Thr Asn Ser Ser Asn Gly Pro Asn 
        35                  40                  45              


Leu Ile Thr Thr Gln Thr Asn Ser Gln Ala Leu Ser Gln Pro Ile Ala 
    50                  55                  60                  


Ser Ser Asn Val His Asp Asn Phe Met Asn Asn Glu Ile Thr Ala Ser 
65                  70                  75                  80  


Lys Ile Asp Asp Gly Asn Asn Ser Lys Pro Leu Ser Pro Gly Trp Thr 
                85                  90                  95      


Asp Gln Thr Ala Tyr Asn Ala Phe Gly Ile Thr Thr Gly Met Phe Asn 
            100                 105                 110         


Thr Thr Thr Met Asp Asp Val Tyr Asn Tyr Leu Phe Asp Asp Glu Asp 
        115                 120                 125             


Thr Pro Pro Asn Pro Lys Lys Glu Ile Cys Met Ala Tyr Pro Tyr Asp 
    130                 135                 140                 


Val Pro Asp Tyr Ala Ser Leu Gly Gly His Met Ala Met Glu Ala Pro 
145                 150                 155                 160 


Gly Ile Leu Met Leu Asp Asp Arg Ala Arg Met Glu Ala Ala Lys Lys 
                165                 170                 175     


Glu Lys Val Glu Gln Ile Leu Ala Glu Phe Gln Leu Gln Glu Glu Asp 
            180                 185                 190         


Leu Lys Lys Val Met Arg Arg Met Gln Lys Glu Met Asp Arg Gly Leu 
        195                 200                 205             


Arg Leu Glu Thr His Glu Glu Ala Ser Val Lys Met Leu Pro Thr Tyr 
    210                 215                 220                 


Val Arg Ser Thr Pro Glu Gly Ser Glu Val Gly Asp Phe Leu Ser Leu 
225                 230                 235                 240 


Asp Leu Gly Gly Thr Asn Phe Arg Val Met Leu Val Lys Val Gly Glu 
                245                 250                 255     


Gly Glu Glu Gly Gln Trp Ser Val Lys Thr Lys His Gln Met Tyr Ser 
            260                 265                 270         


Ile Pro Glu Asp Ala Met Thr Gly Thr Ala Glu Met Leu Phe Asp Tyr 
        275                 280                 285             


Ile Ser Glu Cys Ile Ser Asp Phe Leu Asp Lys His Gln Met Lys His 
    290                 295                 300                 


Lys Lys Leu Pro Leu Gly Phe Thr Phe Ser Phe Pro Val Arg His Glu 
305                 310                 315                 320 


Asp Ile Asp Lys Gly Ile Leu Leu Asn Trp Thr Lys Gly Phe Lys Ala 
                325                 330                 335     


Ser Gly Ala Glu Gly Asn Asn Val Val Gly Leu Leu Arg Asp Ala Ile 
            340                 345                 350         


Lys Arg Arg Gly Asp Phe Glu Met Asp Val Val Ala Met Val Asn Asp 
        355                 360                 365             


Thr Val Ala Thr Met Ile Ser Cys Tyr Tyr Glu Asp His Gln Cys Glu 
    370                 375                 380                 


Val Gly Met Ile Val Gly Thr Gly Cys Asn Ala Cys Tyr Met Glu Glu 
385                 390                 395                 400 


Met Gln Asn Val Glu Leu Val Glu Gly Asp Glu Gly Arg Met Cys Val 
                405                 410                 415     


Asn Thr Glu Trp Gly Ala Phe Gly Asp Ser Gly Glu Leu Asp Glu Phe 
            420                 425                 430         


Leu Leu Glu Tyr Asp Arg Leu Val Asp Glu Ser Ser Ala Asn Pro Gly 
        435                 440                 445             


Gln Gln Leu Tyr Glu Lys Leu Ile Gly Gly Lys Tyr Met Gly Glu Leu 
    450                 455                 460                 


Val Arg Leu Val Leu Leu Arg Leu Val Asp Glu Asn Leu Leu Phe His 
465                 470                 475                 480 


Gly Glu Ala Ser Glu Gln Leu Arg Thr Arg Gly Ala Phe Glu Thr Arg 
                485                 490                 495     


Phe Val Ser Gln Val Glu Ser Asp Thr Gly Asp Arg Lys Gln Ile Tyr 
            500                 505                 510         


Asn Ile Leu Ser Thr Leu Gly Leu Arg Pro Ser Thr Thr Asp Cys Asp 
        515                 520                 525             


Ile Val Arg Arg Ala Cys Glu Ser Val Ser Thr Arg Ala Ala His Met 
    530                 535                 540                 


Cys Ser Ala Gly Leu Ala Gly Val Ile Asn Arg Met Arg Glu Ser Arg 
545                 550                 555                 560 


Ser Glu Asp Val Met Arg Ile Thr Val Gly Val Asp Gly Ser Val Tyr 
                565                 570                 575     


Lys Leu His Pro Ser Phe Lys Glu Arg Phe His Ala Ser Val Arg Arg 
            580                 585                 590         


Leu Thr Pro Ser Cys Glu Ile Thr Phe Ile Glu Ser Glu Glu Gly Ser 
        595                 600                 605             


Gly Arg Gly Ala Ala Leu Val Ser Ala Val Ala Cys Lys Lys Ala Cys 
    610                 615                 620                 


Met Leu Gly Gln Trp Ile Arg Ile Arg Ala Arg Glu Pro Glu Pro Thr 
625                 630                 635                 640 


Ala Pro Pro Glu Pro Thr Ala Pro Pro Glu Pro Thr Ala Pro Pro Ala 
                645                 650                 655     


Glu 
    


