                         SEQUENCE LISTING

<110>  F. Hoffmann-La Roche AG
 
<120>  Antigen binding molecules comprising a TNF family ligand trimer 
       and a Tenascin binding moiety

<130>  P33586

<160>  220   

<170>  PatentIn version 3.5

<210>  1
<211>  3102
<212>  DNA
<213>  Artificial sequence

<220>
<223>  huTNC

<400>  1
atgtccccta tactaggtta ttggaaaatt aagggccttg tgcaacccac tcgacttctt       60

ttggaatatc ttgaagaaaa atatgaagag catttgtatg agcgcgatga aggtgataaa      120

tggcgaaaca aaaagtttga attgggtttg gagtttccca atcttcctta ttatattgat      180

ggtgatgtta aattaacaca gtctatggcc atcatacgtt atatagctga caagcacaac      240

atgttgggtg gttgtccaaa agagcgtgca gagatttcaa tgcttgaagg agcggttttg      300

gatattagat acggtgtttc gagaattgca tatagtaaag actttgaaac tctcaaagtt      360

gattttctta gcaagctacc tgaaatgctg aaaatgttcg aagatcgttt atgtcataaa      420

acatatttaa atggtgatca tgtaacccat cctgacttca tgttgtatga cgctcttgat      480

gttgttttat acatggaccc aatgtgcctg gatgcgttcc caaaattagt ttgttttaaa      540

aaacgtattg aagctatccc acaaattgat aagtacttga aatccagcaa gtatatagca      600

tggcctttgc agggctggca agccacgttt ggtggtggcg accatcctcc aaaatcggat      660

ggttcaacta gtggttctgg tcatcaccat caccatcact ccgcgggtct ggtgccacgc      720

ggtagtactg caattggtat gaaagaaacc gctgctgcta aattcgaacg ccagcacatg      780

gacagcccag atctgggtac cggtggtggc tccggtattg agggacgcgg gtccatggga      840

tatcggggat ccgagctgga cacccccaag gacctgcagg tgtccgagac agccgagaca      900

agcctgaccc tgctgtggaa aacccccctg gccaagttcg accggtacag actgaactac      960

agcctgccca ctggacagtg ggtcggcgtg cagctgcccc ggaacaccac ctcctacgtg     1020

ctgcggggcc tggaacccgg ccaggaatac aacgtcctgc tgacggccga gaagggccgg     1080

cacaagagca agcccgccag agtgaaggcc agcaccgagc aggcccccga gctggaaaac     1140

ctgaccgtga ccgaagtggg ctgggacggc ctgcggctga actggaccgc ggctgaccag     1200

gcctatgagc actttatcat tcaggtgcag gaggccaaca aggtggaggc agctcggaac     1260

ctcaccgtgc ctggcagcct tcgggctgtg gacataccgg gcctcaaggc tgctacgcct     1320

tatacagtct ccatctatgg ggtgatccag ggctatagaa caccagtgct ctctgctgag     1380

gcctccacag gcgaaacacc gaacctgggc gaagtggtgg tggcggaagt gggttgggat     1440

gcgctgaaac tgaactggac cgcgccggaa ggcgcgtatg aatatttttt catccaggtg     1500

caggaagcgg ataccgttga agcggcgcag aacctgaccg ttccgggcgg tctgcgtagc     1560

accgatctgc cgggcctgaa agcggcgacc cattatacca ttaccatccg tggggtgacc     1620

caggacttct ctaccacccc tctgagcgtg gaggtgctga ccgaggaggt acccgacatg     1680

ggcaacctga ccgtgaccga ggtgtcctgg gacgccctgc ggctgaactg gaccaccccc     1740

gacggcacct acgaccagtt cacaatccag gtgcaggaag ccgaccaggt ggaagaagca     1800

cataatctga ccgttccggg tagcctgcgt agcatggaaa ttccgggtct gcgtgcaggc     1860

accccgtata ccgttaccct gcatggtgaa gttcgtggtc atagcacccg tccgctggca     1920

gttgaagttg ttaccgaaga tctgccgcag ctgggtgatc tggcagttag cgaagttggt     1980

tgggatggtc tgcgtctgaa ttggaccgca gcagataatg catatgaaca ttttgtgatc     2040

caggtgcaag aggtgaataa agttgaagca gcccagaatc tgaccctgcc tggttcactg     2100

cgtgcagttg atattccggg actcgaggca gcaaccccgt atcgtgttag catttatggt     2160

gttattcgcg gttatcgtac accggttctg agcgcagaag caagcaccgc aaaagaaccg     2220

gaaattggta atctgaacgt gagcgatatt acaccggaat catttaatct gagctggatg     2280

gcaaccgatg gtatttttga aacctttacc atcgagatca tcgatagcaa tcgtctgctg     2340

gaaaccgtgg aatataatat tagcggtgca gaacgtaccg cacatattag cggtctgcct     2400

ccgagcaccg attttattgt ttatctgagc ggtctggcac cgagcattcg taccaaaacc     2460

attagcgcaa ccgcaaccac cgaagcactg ccgctgctgg aaaatctgac cattagcgat     2520

attaacccgt atggttttac cgtttcatgg atggcaagcg aaaatgcatt tgatagcttt     2580

ctggttacag ttgtggatag cggtaaactg ctggacccgc aagaatttac cctgagcggc     2640

acccagcgca aactggaact gcgtggtctg attaccggta ttggttatga agttatggtg     2700

agcggtttta cccagggtca tcagaccaaa ccgctgcgtg cagaaattgt taccgaagca     2760

atgggtagcc cgaaagaagt tattttttcc gatatcaccg agaattcggc aaccgttagc     2820

tggcgtgcac cgaccgcaca ggttgaaagc tttcgtatta cctatgttcc gattaccggt     2880

ggcaccccga gcatggttac agttgatggc accaaaaccc agacccgtct ggttaaactg     2940

attccgggtg ttgaatatct ggttagcatt attgccatga aaggctttga agaaagcgaa     3000

ccggttagcg gtagctttac cacagctagc ggcctgaacg acatcttcga ggctcagaaa     3060

atcgaatggc acgaaggtac ccatcaccat caccaccact aa                        3102


<210>  2
<211>  2566
<212>  DNA
<213>  Artificial sequence

<220>
<223>  muTNC

<400>  2
tatgtcccct atactaggtt attggaaaat taagggcctt gtgcaaccca ctcgacttct       60

tttggaatat cttgaagaaa aatatgaaga gcatttgtat gagcgcgatg aaggtgataa      120

atggcgaaac aaaaagtttg aattgggttt ggagtttccc aatcttcctt attatattga      180

tggtgatgtt aaattaacac agtctatggc catcatacgt tatatagctg acaagcacaa      240

catgttgggt ggttgtccaa aagagcgtgc agagatttca atgcttgaag gagcggtttt      300

ggatattaga tacggtgttt cgagaattgc atatagtaaa gactttgaaa ctctcaaagt      360

tgattttctt agcaagctac ctgaaatgct gaaaatgttc gaagatcgtt tatgtcataa      420

aacatattta aatggtgatc atgtaaccca tcctgacttc atgttgtatg acgctcttga      480

tgttgtttta tacatggacc caatgtgcct ggatgcgttc ccaaaattag tttgttttaa      540

aaaacgtatt gaagctatcc cacaaattga taagtacttg aaatccagca agtatatagc      600

atggcctttg cagggctggc aagccacgtt tggtggtggc gaccatcctc caaaatcgga      660

tggttcaact agtggttctg gtcatcacca tcaccatcac tccgcgggtc tggtgccacg      720

cggtagtact gcaattggta tgaaagaaac cgctgctgct aaattcgaac gccagcacat      780

ggacagccca gatctgggta ccggtggtgg ctccggtatt gagggacgcg ggtccatggg      840

atatcgggga tccgagctgg acacccccaa ggacctgcag gtgtccgaga cagccgagac      900

aagcctgacc ctgctgtgga aaacccccct ggccaagttc gaccggtaca gactgaacta      960

cagcctgccc actggacagt gggtcggcgt gcagctgccc cggaacacca cctcctacgt     1020

gctgcggggc ctggaacccg gccaggaata caacgtcctg ctgacggccg agaagggccg     1080

gcacaagagc aagcccgcca gagtgaaggc cagcaccgag gaagtgccca gcctggaaaa     1140

cctgaccgtg accgaggccg gctgggacgg cctgcggctg aactggaccg ccgacgacct     1200

ggcctacgag tacttcgtga tccaggtgca ggaagccaac aacgtcgaga cagcccacaa     1260

cttcaccgtg cccggcaacc tgagagccgc cgacatcccc ggcctgaagg tggccacatc     1320

ctaccgggtg tccatctacg gcgtggccag gggctaccgg acccccgtgc tgtccgccga     1380

gacaagcacc ggcaccacgc cgaacctggg cgaagtgacc gtggcggaag tgggttggga     1440

tgcgctgacc ctgaattgga ccgcaccgga aggcgcgtat aaaaactttt tcatccaggt     1500

gctggaagcg gataccaccc agaccgtgca gaacctgacc gtgccgggtg gtctgcgtag     1560

cgtagatctg cctggtctga aagcagcaac ccgctattac attaccctgc gtggtgttac     1620

ccaggatttt ggcaccgcac cgctgagcgt tgaagttctg accgaggatc tgccgcagct     1680

gggtggtctg agcgttaccg aagttagttg ggatggtctg accctgaatt ggaccaccga     1740

tgatctggca tataaacatt ttgtggtgca ggttcaagag gccaataatg ttgaagcagc     1800

acagaatctg accgttccgg gtagcctgcg tgcagttgat attccgggac tgaaagccga     1860

taccccgtat cgtgttagca tttatggtgt tattcagggt tatcgtaccc cgatgctgag     1920

caccgatgtt agcacagcac gtgaaccgga aattggtaat ctgaatgtta gtgatgtgac     1980

cccgaaatca tttaatctga gctggaccgc aaccgatggt atttttgata tgtttaccat     2040

tgaaattatt gatagcaatc gcctgctgca gaccgcagaa cataacatta gcggtgcaga     2100

acgtaccgca catattagcg gtctgcctcc gagcaccgat tttattgttt atctgagcgg     2160

tattgcaccg agcattcgta ccaaaaccat tagcaccacc gcaaccaccg aagcactgac     2220

cgcaatgggt agcccgaaag aagtgatttt tagcgatatt accgaaaata gcgccaccgt     2280

ttcatggcgt gcaccgaccg cacaggttga aagctttcgt attacctatg ttccgattac     2340

cggtggcacc ccgagcatgg ttaccgttga tggcaccaaa acccagaccc gtctggttaa     2400

actgattccg ggtgttgaat atctggttag cattattgcc atgaaaggct ttgaagaaag     2460

cgaaccggtt agcggtagct ttaccacagc tagcggcctg aacgacatct tcgaggctca     2520

gaaaatcgaa tggcacgaag gtacccatca ccatcaccac cactaa                    2566


<210>  3
<211>  2559
<212>  DNA
<213>  Artificial sequence

<220>
<223>  cynoTNC

<400>  3
atgtccccta tactaggtta ttggaaaatt aagggccttg tgcaacccac tcgacttctt       60

ttggaatatc ttgaagaaaa atatgaagag catttgtatg agcgcgatga aggtgataaa      120

tggcgaaaca aaaagtttga attgggtttg gagtttccca atcttcctta ttatattgat      180

ggtgatgtta aattaacaca gtctatggcc atcatacgtt atatagctga caagcacaac      240

atgttgggtg gttgtccaaa agagcgtgca gagatttcaa tgcttgaagg agcggttttg      300

gatattagat acggtgtttc gagaattgca tatagtaaag actttgaaac tctcaaagtt      360

gattttctta gcaagctacc tgaaatgctg aaaatgttcg aagatcgttt atgtcataaa      420

acatatttaa atggtgatca tgtaacccat cctgacttca tgttgtatga cgctcttgat      480

gttgttttat acatggaccc aatgtgcctg gatgcgttcc caaaattagt ttgttttaaa      540

aaacgtattg aagctatccc acaaattgat aagtacttga aatccagcaa gtatatagca      600

tggcctttgc agggctggca agccacgttt ggtggtggcg accatcctcc aaaatcggat      660

ggttcaacta gtggttctgg tcatcaccat caccatcact ccgcgggtct ggtgccacgc      720

ggtagtactg caattggtat gaaagaaacc gctgctgcta aattcgaacg ccagcacatg      780

gacagcccag atctgggtac cggtggtggc tccggtattg agggacgcgg gtccatggga      840

tatcggggat ccgaactgga taccccgaaa gatctgcgtg ttagcgaaac cgcagaaacc      900

agcctgaccc tgttttggaa aacaccgctg gcaaaatttg atcgttatcg tctgaattat      960

agcctgccga ccggtcagtg ggttggtgtt cagctgcctc gtaataccac cagttatgtt     1020

ctgcgtggtc tggaaccggg tcaagaatat aacgttctgc tgaccgcaga aaaaggtcgt     1080

cataaaagca aaccggcacg tgttaaagca agcaccgaac aggcaccgga actggaaaat     1140

ctgaccgtta ccgaagttgg ctgggatggc ctgcgcctga actggacggc tgcggaccag     1200

gcctacgaac acttcgttat ccaggtgcaa gaagccaaca aagtagaagc cgctcagaat     1260

ctgacggttc cgggaaatct gcgtgcagtt gatattccgg gtctgaaagc agcaaccccg     1320

tataccgtta gcatttatgg tgttattcag ggttatcgta caccggttct gagtgccgaa     1380

gccagcaccg gtgaaacccc gaatctgggt gaagttatgg ttagcgaagt gggctgggat     1440

gcactgaaac tgaattggac agttccggaa ggtgcctatg aatacttttt cattcaggtt     1500

caagaagcgg ataccgttga agccgctcag aatcataccg ttccgggtgg tctgcgtagc     1560

accgatctgc ctggcctgaa agccgctacc cattacacca ttaccattcg tggtgttacc     1620

caggatttta gcaccacacc gctgagcgtt gaagttctga cagaagaact gccgcagctg     1680

ggtgatctgg cagttagcga agttggttgg gatggtctgc gtctgaattg gaccgcagca     1740

gatcaggcat atgaacattt tgttatccag gtgcaagaag tgaacaaagt tgaagcagca     1800

cagaatctga ccgttccggg tagcctgcgt gcagttgata ttccgggtct gaaagcagca     1860

accccgtata ccgttagcat ttatggtgtt attcgcggtt atcgtacacc ggttctgagc     1920

gcagaagcaa gcaccgcaaa agaaccggaa attggtaatc tgaacgtgag cgatattaca     1980

ccggaaagtt ttagcctgag ctggaccgca accgatggta tttttgaaac ctttaccatc     2040

gagatcatcg atagcaatcg tctgctggaa atcgtggaat ataacattag cggtgcagaa     2100

cgtaccgcac atattagcgg tctgcctccg agcaccgatt ttattgttta tctgagcggt     2160

ctggcaccga gctttcgtac caaaaccatt agcgcaaccg caaccaccga agcactgacc     2220

gcaatgggta gcccgaaaga agtgattttt agcgatatta ccgaaaatag cgccaccgtt     2280

tcatggcgtg caccgaccgc acaggttgaa agctttcgta ttacctatgt tccgattacc     2340

ggtggcaccc cgagcatggt taccgtggat ggcaccaaaa cccagacccg tctggttaaa     2400

ctggttccgg gtgttgaata tctggtgaat atcattgcca tgaaaggctt tgaagaaagc     2460

gaaccggtta gcggtagctt taccaccgct agcggcctga acgacatctt cgaggctcag     2520

aaaatcgaat ggcacgaagg tacccatcac catcaccac                            2559


<210>  4
<211>  1033
<212>  PRT
<213>  Artificial sequence

<220>
<223>  huTNC

<400>  4

Met Ser Pro Ile Leu Gly Tyr Trp Lys Ile Lys Gly Leu Val Gln Pro 
1               5                   10                  15      


Thr Arg Leu Leu Leu Glu Tyr Leu Glu Glu Lys Tyr Glu Glu His Leu 
            20                  25                  30          


Tyr Glu Arg Asp Glu Gly Asp Lys Trp Arg Asn Lys Lys Phe Glu Leu 
        35                  40                  45              


Gly Leu Glu Phe Pro Asn Leu Pro Tyr Tyr Ile Asp Gly Asp Val Lys 
    50                  55                  60                  


Leu Thr Gln Ser Met Ala Ile Ile Arg Tyr Ile Ala Asp Lys His Asn 
65                  70                  75                  80  


Met Leu Gly Gly Cys Pro Lys Glu Arg Ala Glu Ile Ser Met Leu Glu 
                85                  90                  95      


Gly Ala Val Leu Asp Ile Arg Tyr Gly Val Ser Arg Ile Ala Tyr Ser 
            100                 105                 110         


Lys Asp Phe Glu Thr Leu Lys Val Asp Phe Leu Ser Lys Leu Pro Glu 
        115                 120                 125             


Met Leu Lys Met Phe Glu Asp Arg Leu Cys His Lys Thr Tyr Leu Asn 
    130                 135                 140                 


Gly Asp His Val Thr His Pro Asp Phe Met Leu Tyr Asp Ala Leu Asp 
145                 150                 155                 160 


Val Val Leu Tyr Met Asp Pro Met Cys Leu Asp Ala Phe Pro Lys Leu 
                165                 170                 175     


Val Cys Phe Lys Lys Arg Ile Glu Ala Ile Pro Gln Ile Asp Lys Tyr 
            180                 185                 190         


Leu Lys Ser Ser Lys Tyr Ile Ala Trp Pro Leu Gln Gly Trp Gln Ala 
        195                 200                 205             


Thr Phe Gly Gly Gly Asp His Pro Pro Lys Ser Asp Gly Ser Thr Ser 
    210                 215                 220                 


Gly Ser Gly His His His His His His Ser Ala Gly Leu Val Pro Arg 
225                 230                 235                 240 


Gly Ser Thr Ala Ile Gly Met Lys Glu Thr Ala Ala Ala Lys Phe Glu 
                245                 250                 255     


Arg Gln His Met Asp Ser Pro Asp Leu Gly Thr Gly Gly Gly Ser Gly 
            260                 265                 270         


Ile Glu Gly Arg Gly Ser Met Gly Tyr Arg Gly Ser Glu Leu Asp Thr 
        275                 280                 285             


Pro Lys Asp Leu Gln Val Ser Glu Thr Ala Glu Thr Ser Leu Thr Leu 
    290                 295                 300                 


Leu Trp Lys Thr Pro Leu Ala Lys Phe Asp Arg Tyr Arg Leu Asn Tyr 
305                 310                 315                 320 


Ser Leu Pro Thr Gly Gln Trp Val Gly Val Gln Leu Pro Arg Asn Thr 
                325                 330                 335     


Thr Ser Tyr Val Leu Arg Gly Leu Glu Pro Gly Gln Glu Tyr Asn Val 
            340                 345                 350         


Leu Leu Thr Ala Glu Lys Gly Arg His Lys Ser Lys Pro Ala Arg Val 
        355                 360                 365             


Lys Ala Ser Thr Glu Gln Ala Pro Glu Leu Glu Asn Leu Thr Val Thr 
    370                 375                 380                 


Glu Val Gly Trp Asp Gly Leu Arg Leu Asn Trp Thr Ala Ala Asp Gln 
385                 390                 395                 400 


Ala Tyr Glu His Phe Ile Ile Gln Val Gln Glu Ala Asn Lys Val Glu 
                405                 410                 415     


Ala Ala Arg Asn Leu Thr Val Pro Gly Ser Leu Arg Ala Val Asp Ile 
            420                 425                 430         


Pro Gly Leu Lys Ala Ala Thr Pro Tyr Thr Val Ser Ile Tyr Gly Val 
        435                 440                 445             


Ile Gln Gly Tyr Arg Thr Pro Val Leu Ser Ala Glu Ala Ser Thr Gly 
    450                 455                 460                 


Glu Thr Pro Asn Leu Gly Glu Val Val Val Ala Glu Val Gly Trp Asp 
465                 470                 475                 480 


Ala Leu Lys Leu Asn Trp Thr Ala Pro Glu Gly Ala Tyr Glu Tyr Phe 
                485                 490                 495     


Phe Ile Gln Val Gln Glu Ala Asp Thr Val Glu Ala Ala Gln Asn Leu 
            500                 505                 510         


Thr Val Pro Gly Gly Leu Arg Ser Thr Asp Leu Pro Gly Leu Lys Ala 
        515                 520                 525             


Ala Thr His Tyr Thr Ile Thr Ile Arg Gly Val Thr Gln Asp Phe Ser 
    530                 535                 540                 


Thr Thr Pro Leu Ser Val Glu Val Leu Thr Glu Glu Val Pro Asp Met 
545                 550                 555                 560 


Gly Asn Leu Thr Val Thr Glu Val Ser Trp Asp Ala Leu Arg Leu Asn 
                565                 570                 575     


Trp Thr Thr Pro Asp Gly Thr Tyr Asp Gln Phe Thr Ile Gln Val Gln 
            580                 585                 590         


Glu Ala Asp Gln Val Glu Glu Ala His Asn Leu Thr Val Pro Gly Ser 
        595                 600                 605             


Leu Arg Ser Met Glu Ile Pro Gly Leu Arg Ala Gly Thr Pro Tyr Thr 
    610                 615                 620                 


Val Thr Leu His Gly Glu Val Arg Gly His Ser Thr Arg Pro Leu Ala 
625                 630                 635                 640 


Val Glu Val Val Thr Glu Asp Leu Pro Gln Leu Gly Asp Leu Ala Val 
                645                 650                 655     


Ser Glu Val Gly Trp Asp Gly Leu Arg Leu Asn Trp Thr Ala Ala Asp 
            660                 665                 670         


Asn Ala Tyr Glu His Phe Val Ile Gln Val Gln Glu Val Asn Lys Val 
        675                 680                 685             


Glu Ala Ala Gln Asn Leu Thr Leu Pro Gly Ser Leu Arg Ala Val Asp 
    690                 695                 700                 


Ile Pro Gly Leu Glu Ala Ala Thr Pro Tyr Arg Val Ser Ile Tyr Gly 
705                 710                 715                 720 


Val Ile Arg Gly Tyr Arg Thr Pro Val Leu Ser Ala Glu Ala Ser Thr 
                725                 730                 735     


Ala Lys Glu Pro Glu Ile Gly Asn Leu Asn Val Ser Asp Ile Thr Pro 
            740                 745                 750         


Glu Ser Phe Asn Leu Ser Trp Met Ala Thr Asp Gly Ile Phe Glu Thr 
        755                 760                 765             


Phe Thr Ile Glu Ile Ile Asp Ser Asn Arg Leu Leu Glu Thr Val Glu 
    770                 775                 780                 


Tyr Asn Ile Ser Gly Ala Glu Arg Thr Ala His Ile Ser Gly Leu Pro 
785                 790                 795                 800 


Pro Ser Thr Asp Phe Ile Val Tyr Leu Ser Gly Leu Ala Pro Ser Ile 
                805                 810                 815     


Arg Thr Lys Thr Ile Ser Ala Thr Ala Thr Thr Glu Ala Leu Pro Leu 
            820                 825                 830         


Leu Glu Asn Leu Thr Ile Ser Asp Ile Asn Pro Tyr Gly Phe Thr Val 
        835                 840                 845             


Ser Trp Met Ala Ser Glu Asn Ala Phe Asp Ser Phe Leu Val Thr Val 
    850                 855                 860                 


Val Asp Ser Gly Lys Leu Leu Asp Pro Gln Glu Phe Thr Leu Ser Gly 
865                 870                 875                 880 


Thr Gln Arg Lys Leu Glu Leu Arg Gly Leu Ile Thr Gly Ile Gly Tyr 
                885                 890                 895     


Glu Val Met Val Ser Gly Phe Thr Gln Gly His Gln Thr Lys Pro Leu 
            900                 905                 910         


Arg Ala Glu Ile Val Thr Glu Ala Met Gly Ser Pro Lys Glu Val Ile 
        915                 920                 925             


Phe Ser Asp Ile Thr Glu Asn Ser Ala Thr Val Ser Trp Arg Ala Pro 
    930                 935                 940                 


Thr Ala Gln Val Glu Ser Phe Arg Ile Thr Tyr Val Pro Ile Thr Gly 
945                 950                 955                 960 


Gly Thr Pro Ser Met Val Thr Val Asp Gly Thr Lys Thr Gln Thr Arg 
                965                 970                 975     


Leu Val Lys Leu Ile Pro Gly Val Glu Tyr Leu Val Ser Ile Ile Ala 
            980                 985                 990         


Met Lys Gly Phe Glu Glu Ser Glu  Pro Val Ser Gly Ser  Phe Thr Thr 
        995                 1000                 1005             


Ala Ser  Gly Leu Asn Asp Ile  Phe Glu Ala Gln Lys  Ile Glu Trp 
    1010                 1015                 1020             


His Glu  Gly Thr His His His  His His His 
    1025                 1030             


<210>  5
<211>  854
<212>  PRT
<213>  Artificial sequence

<220>
<223>  muTNC

<400>  5

Met Ser Pro Ile Leu Gly Tyr Trp Lys Ile Lys Gly Leu Val Gln Pro 
1               5                   10                  15      


Thr Arg Leu Leu Leu Glu Tyr Leu Glu Glu Lys Tyr Glu Glu His Leu 
            20                  25                  30          


Tyr Glu Arg Asp Glu Gly Asp Lys Trp Arg Asn Lys Lys Phe Glu Leu 
        35                  40                  45              


Gly Leu Glu Phe Pro Asn Leu Pro Tyr Tyr Ile Asp Gly Asp Val Lys 
    50                  55                  60                  


Leu Thr Gln Ser Met Ala Ile Ile Arg Tyr Ile Ala Asp Lys His Asn 
65                  70                  75                  80  


Met Leu Gly Gly Cys Pro Lys Glu Arg Ala Glu Ile Ser Met Leu Glu 
                85                  90                  95      


Gly Ala Val Leu Asp Ile Arg Tyr Gly Val Ser Arg Ile Ala Tyr Ser 
            100                 105                 110         


Lys Asp Phe Glu Thr Leu Lys Val Asp Phe Leu Ser Lys Leu Pro Glu 
        115                 120                 125             


Met Leu Lys Met Phe Glu Asp Arg Leu Cys His Lys Thr Tyr Leu Asn 
    130                 135                 140                 


Gly Asp His Val Thr His Pro Asp Phe Met Leu Tyr Asp Ala Leu Asp 
145                 150                 155                 160 


Val Val Leu Tyr Met Asp Pro Met Cys Leu Asp Ala Phe Pro Lys Leu 
                165                 170                 175     


Val Cys Phe Lys Lys Arg Ile Glu Ala Ile Pro Gln Ile Asp Lys Tyr 
            180                 185                 190         


Leu Lys Ser Ser Lys Tyr Ile Ala Trp Pro Leu Gln Gly Trp Gln Ala 
        195                 200                 205             


Thr Phe Gly Gly Gly Asp His Pro Pro Lys Ser Asp Gly Ser Thr Ser 
    210                 215                 220                 


Gly Ser Gly His His His His His His Ser Ala Gly Leu Val Pro Arg 
225                 230                 235                 240 


Gly Ser Thr Ala Ile Gly Met Lys Glu Thr Ala Ala Ala Lys Phe Glu 
                245                 250                 255     


Arg Gln His Met Asp Ser Pro Asp Leu Gly Thr Gly Gly Gly Ser Gly 
            260                 265                 270         


Ile Glu Gly Arg Gly Ser Met Gly Tyr Arg Gly Ser Glu Leu Asp Thr 
        275                 280                 285             


Pro Lys Asp Leu Gln Val Ser Glu Thr Ala Glu Thr Ser Leu Thr Leu 
    290                 295                 300                 


Leu Trp Lys Thr Pro Leu Ala Lys Phe Asp Arg Tyr Arg Leu Asn Tyr 
305                 310                 315                 320 


Ser Leu Pro Thr Gly Gln Trp Val Gly Val Gln Leu Pro Arg Asn Thr 
                325                 330                 335     


Thr Ser Tyr Val Leu Arg Gly Leu Glu Pro Gly Gln Glu Tyr Asn Val 
            340                 345                 350         


Leu Leu Thr Ala Glu Lys Gly Arg His Lys Ser Lys Pro Ala Arg Val 
        355                 360                 365             


Lys Ala Ser Thr Glu Glu Val Pro Ser Leu Glu Asn Leu Thr Val Thr 
    370                 375                 380                 


Glu Ala Gly Trp Asp Gly Leu Arg Leu Asn Trp Thr Ala Asp Asp Leu 
385                 390                 395                 400 


Ala Tyr Glu Tyr Phe Val Ile Gln Val Gln Glu Ala Asn Asn Val Glu 
                405                 410                 415     


Thr Ala His Asn Phe Thr Val Pro Gly Asn Leu Arg Ala Ala Asp Ile 
            420                 425                 430         


Pro Gly Leu Lys Val Ala Thr Ser Tyr Arg Val Ser Ile Tyr Gly Val 
        435                 440                 445             


Ala Arg Gly Tyr Arg Thr Pro Val Leu Ser Ala Glu Thr Ser Thr Gly 
    450                 455                 460                 


Thr Thr Pro Asn Leu Gly Glu Val Thr Val Ala Glu Val Gly Trp Asp 
465                 470                 475                 480 


Ala Leu Thr Leu Asn Trp Thr Ala Pro Glu Gly Ala Tyr Lys Asn Phe 
                485                 490                 495     


Phe Ile Gln Val Leu Glu Ala Asp Thr Thr Gln Thr Val Gln Asn Leu 
            500                 505                 510         


Thr Val Pro Gly Gly Leu Arg Ser Val Asp Leu Pro Gly Leu Lys Ala 
        515                 520                 525             


Ala Thr Arg Tyr Tyr Ile Thr Leu Arg Gly Val Thr Gln Asp Phe Gly 
    530                 535                 540                 


Thr Ala Pro Leu Ser Val Glu Val Leu Thr Glu Asp Leu Pro Gln Leu 
545                 550                 555                 560 


Gly Gly Leu Ser Val Thr Glu Val Ser Trp Asp Gly Leu Thr Leu Asn 
                565                 570                 575     


Trp Thr Thr Asp Asp Leu Ala Tyr Lys His Phe Val Val Gln Val Gln 
            580                 585                 590         


Glu Ala Asn Asn Val Glu Ala Ala Gln Asn Leu Thr Val Pro Gly Ser 
        595                 600                 605             


Leu Arg Ala Val Asp Ile Pro Gly Leu Lys Ala Asp Thr Pro Tyr Arg 
    610                 615                 620                 


Val Ser Ile Tyr Gly Val Ile Gln Gly Tyr Arg Thr Pro Met Leu Ser 
625                 630                 635                 640 


Thr Asp Val Ser Thr Ala Arg Glu Pro Glu Ile Gly Asn Leu Asn Val 
                645                 650                 655     


Ser Asp Val Thr Pro Lys Ser Phe Asn Leu Ser Trp Thr Ala Thr Asp 
            660                 665                 670         


Gly Ile Phe Asp Met Phe Thr Ile Glu Ile Ile Asp Ser Asn Arg Leu 
        675                 680                 685             


Leu Gln Thr Ala Glu His Asn Ile Ser Gly Ala Glu Arg Thr Ala His 
    690                 695                 700                 


Ile Ser Gly Leu Pro Pro Ser Thr Asp Phe Ile Val Tyr Leu Ser Gly 
705                 710                 715                 720 


Ile Ala Pro Ser Ile Arg Thr Lys Thr Ile Ser Thr Thr Ala Thr Thr 
                725                 730                 735     


Glu Ala Leu Thr Ala Met Gly Ser Pro Lys Glu Val Ile Phe Ser Asp 
            740                 745                 750         


Ile Thr Glu Asn Ser Ala Thr Val Ser Trp Arg Ala Pro Thr Ala Gln 
        755                 760                 765             


Val Glu Ser Phe Arg Ile Thr Tyr Val Pro Ile Thr Gly Gly Thr Pro 
    770                 775                 780                 


Ser Met Val Thr Val Asp Gly Thr Lys Thr Gln Thr Arg Leu Val Lys 
785                 790                 795                 800 


Leu Ile Pro Gly Val Glu Tyr Leu Val Ser Ile Ile Ala Met Lys Gly 
                805                 810                 815     


Phe Glu Glu Ser Glu Pro Val Ser Gly Ser Phe Thr Thr Ala Ser Gly 
            820                 825                 830         


Leu Asn Asp Ile Phe Glu Ala Gln Lys Ile Glu Trp His Glu Gly Thr 
        835                 840                 845             


His His His His His His 
    850                 


<210>  6
<211>  854
<212>  PRT
<213>  Artificial sequence

<220>
<223>  cynoTNC

<400>  6

Met Ser Pro Ile Leu Gly Tyr Trp Lys Ile Lys Gly Leu Val Gln Pro 
1               5                   10                  15      


Thr Arg Leu Leu Leu Glu Tyr Leu Glu Glu Lys Tyr Glu Glu His Leu 
            20                  25                  30          


Tyr Glu Arg Asp Glu Gly Asp Lys Trp Arg Asn Lys Lys Phe Glu Leu 
        35                  40                  45              


Gly Leu Glu Phe Pro Asn Leu Pro Tyr Tyr Ile Asp Gly Asp Val Lys 
    50                  55                  60                  


Leu Thr Gln Ser Met Ala Ile Ile Arg Tyr Ile Ala Asp Lys His Asn 
65                  70                  75                  80  


Met Leu Gly Gly Cys Pro Lys Glu Arg Ala Glu Ile Ser Met Leu Glu 
                85                  90                  95      


Gly Ala Val Leu Asp Ile Arg Tyr Gly Val Ser Arg Ile Ala Tyr Ser 
            100                 105                 110         


Lys Asp Phe Glu Thr Leu Lys Val Asp Phe Leu Ser Lys Leu Pro Glu 
        115                 120                 125             


Met Leu Lys Met Phe Glu Asp Arg Leu Cys His Lys Thr Tyr Leu Asn 
    130                 135                 140                 


Gly Asp His Val Thr His Pro Asp Phe Met Leu Tyr Asp Ala Leu Asp 
145                 150                 155                 160 


Val Val Leu Tyr Met Asp Pro Met Cys Leu Asp Ala Phe Pro Lys Leu 
                165                 170                 175     


Val Cys Phe Lys Lys Arg Ile Glu Ala Ile Pro Gln Ile Asp Lys Tyr 
            180                 185                 190         


Leu Lys Ser Ser Lys Tyr Ile Ala Trp Pro Leu Gln Gly Trp Gln Ala 
        195                 200                 205             


Thr Phe Gly Gly Gly Asp His Pro Pro Lys Ser Asp Gly Ser Thr Ser 
    210                 215                 220                 


Gly Ser Gly His His His His His His Ser Ala Gly Leu Val Pro Arg 
225                 230                 235                 240 


Gly Ser Thr Ala Ile Gly Met Lys Glu Thr Ala Ala Ala Lys Phe Glu 
                245                 250                 255     


Arg Gln His Met Asp Ser Pro Asp Leu Gly Thr Gly Gly Gly Ser Gly 
            260                 265                 270         


Ile Glu Gly Arg Gly Ser Met Gly Tyr Arg Gly Ser Glu Leu Asp Thr 
        275                 280                 285             


Pro Lys Asp Leu Arg Val Ser Glu Thr Ala Glu Thr Ser Leu Thr Leu 
    290                 295                 300                 


Phe Trp Lys Thr Pro Leu Ala Lys Phe Asp Arg Tyr Arg Leu Asn Tyr 
305                 310                 315                 320 


Ser Leu Pro Thr Gly Gln Trp Val Gly Val Gln Leu Pro Arg Asn Thr 
                325                 330                 335     


Thr Ser Tyr Val Leu Arg Gly Leu Glu Pro Gly Gln Glu Tyr Asn Val 
            340                 345                 350         


Leu Leu Thr Ala Glu Lys Gly Arg His Lys Ser Lys Pro Ala Arg Val 
        355                 360                 365             


Lys Ala Ser Thr Glu Gln Ala Pro Glu Leu Glu Asn Leu Thr Val Thr 
    370                 375                 380                 


Glu Val Gly Trp Asp Gly Leu Arg Leu Asn Trp Thr Ala Ala Asp Gln 
385                 390                 395                 400 


Ala Tyr Glu His Phe Val Ile Gln Val Gln Glu Ala Asn Lys Val Glu 
                405                 410                 415     


Ala Ala Gln Asn Leu Thr Val Pro Gly Asn Leu Arg Ala Val Asp Ile 
            420                 425                 430         


Pro Gly Leu Lys Ala Ala Thr Pro Tyr Thr Val Ser Ile Tyr Gly Val 
        435                 440                 445             


Ile Gln Gly Tyr Arg Thr Pro Val Leu Ser Ala Glu Ala Ser Thr Gly 
    450                 455                 460                 


Glu Thr Pro Asn Leu Gly Glu Val Met Val Ser Glu Val Gly Trp Asp 
465                 470                 475                 480 


Ala Leu Lys Leu Asn Trp Thr Val Pro Glu Gly Ala Tyr Glu Tyr Phe 
                485                 490                 495     


Phe Ile Gln Val Gln Glu Ala Asp Thr Val Glu Ala Ala Gln Asn His 
            500                 505                 510         


Thr Val Pro Gly Gly Leu Arg Ser Thr Asp Leu Pro Gly Leu Lys Ala 
        515                 520                 525             


Ala Thr His Tyr Thr Ile Thr Ile Arg Gly Val Thr Gln Asp Phe Ser 
    530                 535                 540                 


Thr Thr Pro Leu Ser Val Glu Val Leu Thr Glu Glu Leu Pro Gln Leu 
545                 550                 555                 560 


Gly Asp Leu Ala Val Ser Glu Val Gly Trp Asp Gly Leu Arg Leu Asn 
                565                 570                 575     


Trp Thr Ala Ala Asp Gln Ala Tyr Glu His Phe Val Ile Gln Val Gln 
            580                 585                 590         


Glu Val Asn Lys Val Glu Ala Ala Gln Asn Leu Thr Val Pro Gly Ser 
        595                 600                 605             


Leu Arg Ala Val Asp Ile Pro Gly Leu Lys Ala Ala Thr Pro Tyr Thr 
    610                 615                 620                 


Val Ser Ile Tyr Gly Val Ile Arg Gly Tyr Arg Thr Pro Val Leu Ser 
625                 630                 635                 640 


Ala Glu Ala Ser Thr Ala Lys Glu Pro Glu Ile Gly Asn Leu Asn Val 
                645                 650                 655     


Ser Asp Ile Thr Pro Glu Ser Phe Ser Leu Ser Trp Thr Ala Thr Asp 
            660                 665                 670         


Gly Ile Phe Glu Thr Phe Thr Ile Glu Ile Ile Asp Ser Asn Arg Leu 
        675                 680                 685             


Leu Glu Ile Val Glu Tyr Asn Ile Ser Gly Ala Glu Arg Thr Ala His 
    690                 695                 700                 


Ile Ser Gly Leu Pro Pro Ser Thr Asp Phe Ile Val Tyr Leu Ser Gly 
705                 710                 715                 720 


Leu Ala Pro Ser Phe Arg Thr Lys Thr Ile Ser Ala Thr Ala Thr Thr 
                725                 730                 735     


Glu Ala Leu Thr Ala Met Gly Ser Pro Lys Glu Val Ile Phe Ser Asp 
            740                 745                 750         


Ile Thr Glu Asn Ser Ala Thr Val Ser Trp Arg Ala Pro Thr Ala Gln 
        755                 760                 765             


Val Glu Ser Phe Arg Ile Thr Tyr Val Pro Ile Thr Gly Gly Thr Pro 
    770                 775                 780                 


Ser Met Val Thr Val Asp Gly Thr Lys Thr Gln Thr Arg Leu Val Lys 
785                 790                 795                 800 


Leu Val Pro Gly Val Glu Tyr Leu Val Asn Ile Ile Ala Met Lys Gly 
                805                 810                 815     


Phe Glu Glu Ser Glu Pro Val Ser Gly Ser Phe Thr Thr Ala Ser Gly 
            820                 825                 830         


Leu Asn Asp Ile Phe Glu Ala Gln Lys Ile Glu Trp His Glu Gly Thr 
        835                 840                 845             


His His His His His His 
    850                 


<210>  7
<211>  1033
<212>  PRT
<213>  Artificial sequence

<220>
<223>  GST huTNC fn5 A1234 BC fn6 B

<400>  7

Met Ser Pro Ile Leu Gly Tyr Trp Lys Ile Lys Gly Leu Val Gln Pro 
1               5                   10                  15      


Thr Arg Leu Leu Leu Glu Tyr Leu Glu Glu Lys Tyr Glu Glu His Leu 
            20                  25                  30          


Tyr Glu Arg Asp Glu Gly Asp Lys Trp Arg Asn Lys Lys Phe Glu Leu 
        35                  40                  45              


Gly Leu Glu Phe Pro Asn Leu Pro Tyr Tyr Ile Asp Gly Asp Val Lys 
    50                  55                  60                  


Leu Thr Gln Ser Met Ala Ile Ile Arg Tyr Ile Ala Asp Lys His Asn 
65                  70                  75                  80  


Met Leu Gly Gly Cys Pro Lys Glu Arg Ala Glu Ile Ser Met Leu Glu 
                85                  90                  95      


Gly Ala Val Leu Asp Ile Arg Tyr Gly Val Ser Arg Ile Ala Tyr Ser 
            100                 105                 110         


Lys Asp Phe Glu Thr Leu Lys Val Asp Phe Leu Ser Lys Leu Pro Glu 
        115                 120                 125             


Met Leu Lys Met Phe Glu Asp Arg Leu Cys His Lys Thr Tyr Leu Asn 
    130                 135                 140                 


Gly Asp His Val Thr His Pro Asp Phe Met Leu Tyr Asp Ala Leu Asp 
145                 150                 155                 160 


Val Val Leu Tyr Met Asp Pro Met Cys Leu Asp Ala Phe Pro Lys Leu 
                165                 170                 175     


Val Cys Phe Lys Lys Arg Ile Glu Ala Ile Pro Gln Ile Asp Lys Tyr 
            180                 185                 190         


Leu Lys Ser Ser Lys Tyr Ile Ala Trp Pro Leu Gln Gly Trp Gln Ala 
        195                 200                 205             


Thr Phe Gly Gly Gly Asp His Pro Pro Lys Ser Asp Gly Ser Thr Ser 
    210                 215                 220                 


Gly Ser Gly His His His His His His Ser Ala Gly Leu Val Pro Arg 
225                 230                 235                 240 


Gly Ser Thr Ala Ile Gly Met Lys Glu Thr Ala Ala Ala Lys Phe Glu 
                245                 250                 255     


Arg Gln His Met Asp Ser Pro Asp Leu Gly Thr Gly Gly Gly Ser Gly 
            260                 265                 270         


Ile Glu Gly Arg Gly Ser Met Gly Tyr Arg Gly Ser Glu Leu Asp Thr 
        275                 280                 285             


Pro Lys Asp Leu Gln Val Ser Glu Thr Ala Glu Thr Ser Leu Thr Leu 
    290                 295                 300                 


Leu Trp Lys Thr Pro Leu Ala Lys Phe Asp Arg Tyr Arg Leu Asn Tyr 
305                 310                 315                 320 


Ser Leu Pro Thr Gly Gln Trp Val Gly Val Gln Leu Pro Arg Asn Thr 
                325                 330                 335     


Thr Ser Tyr Val Leu Arg Gly Leu Glu Pro Gly Gln Glu Tyr Asn Val 
            340                 345                 350         


Leu Leu Thr Ala Glu Lys Gly Arg His Lys Ser Lys Pro Ala Arg Val 
        355                 360                 365             


Lys Ala Ser Thr Glu Gln Ala Pro Glu Leu Glu Asn Leu Thr Val Thr 
    370                 375                 380                 


Glu Val Gly Trp Asp Gly Leu Arg Leu Asn Trp Thr Ala Ala Asp Gln 
385                 390                 395                 400 


Ala Tyr Glu His Phe Ile Ile Gln Val Gln Glu Ala Asn Lys Val Glu 
                405                 410                 415     


Ala Ala Arg Asn Leu Thr Val Pro Gly Ser Leu Arg Ala Val Asp Ile 
            420                 425                 430         


Pro Gly Leu Lys Ala Ala Thr Pro Tyr Thr Val Ser Ile Tyr Gly Val 
        435                 440                 445             


Ile Gln Gly Tyr Arg Thr Pro Val Leu Ser Ala Glu Ala Ser Thr Gly 
    450                 455                 460                 


Glu Thr Pro Asn Leu Gly Glu Val Val Val Ala Glu Val Gly Trp Asp 
465                 470                 475                 480 


Ala Leu Lys Leu Asn Trp Thr Ala Pro Glu Gly Ala Tyr Glu Tyr Phe 
                485                 490                 495     


Phe Ile Gln Val Gln Glu Ala Asp Thr Val Glu Ala Ala Gln Asn Leu 
            500                 505                 510         


Thr Val Pro Gly Gly Leu Arg Ser Thr Asp Leu Pro Gly Leu Lys Ala 
        515                 520                 525             


Ala Thr His Tyr Thr Ile Thr Ile Arg Gly Val Thr Gln Asp Phe Ser 
    530                 535                 540                 


Thr Thr Pro Leu Ser Val Glu Val Leu Thr Glu Glu Val Pro Asp Met 
545                 550                 555                 560 


Gly Asn Leu Thr Val Thr Glu Val Ser Trp Asp Ala Leu Arg Leu Asn 
                565                 570                 575     


Trp Thr Thr Pro Asp Gly Thr Tyr Asp Gln Phe Thr Ile Gln Val Gln 
            580                 585                 590         


Glu Ala Asp Gln Val Glu Glu Ala His Asn Leu Thr Val Pro Gly Ser 
        595                 600                 605             


Leu Arg Ser Met Glu Ile Pro Gly Leu Arg Ala Gly Thr Pro Tyr Thr 
    610                 615                 620                 


Val Thr Leu His Gly Glu Val Arg Gly His Ser Thr Arg Pro Leu Ala 
625                 630                 635                 640 


Val Glu Val Val Thr Glu Asp Leu Pro Gln Leu Gly Asp Leu Ala Val 
                645                 650                 655     


Ser Glu Val Gly Trp Asp Gly Leu Arg Leu Asn Trp Thr Ala Ala Asp 
            660                 665                 670         


Asn Ala Tyr Glu His Phe Val Ile Gln Val Gln Glu Val Asn Lys Val 
        675                 680                 685             


Glu Ala Ala Gln Asn Leu Thr Leu Pro Gly Ser Leu Arg Ala Val Asp 
    690                 695                 700                 


Ile Pro Gly Leu Glu Ala Ala Thr Pro Tyr Arg Val Ser Ile Tyr Gly 
705                 710                 715                 720 


Val Ile Arg Gly Tyr Arg Thr Pro Val Leu Ser Ala Glu Ala Ser Thr 
                725                 730                 735     


Ala Lys Glu Pro Glu Ile Gly Asn Leu Asn Val Ser Asp Ile Thr Pro 
            740                 745                 750         


Glu Ser Phe Asn Leu Ser Trp Met Ala Thr Asp Gly Ile Phe Glu Thr 
        755                 760                 765             


Phe Thr Ile Glu Ile Ile Asp Ser Asn Arg Leu Leu Glu Thr Val Glu 
    770                 775                 780                 


Tyr Asn Ile Ser Gly Ala Glu Arg Thr Ala His Ile Ser Gly Leu Pro 
785                 790                 795                 800 


Pro Ser Thr Asp Phe Ile Val Tyr Leu Ser Gly Leu Ala Pro Ser Ile 
                805                 810                 815     


Arg Thr Lys Thr Ile Ser Ala Thr Ala Thr Thr Glu Ala Leu Pro Leu 
            820                 825                 830         


Leu Glu Asn Leu Thr Ile Ser Asp Ile Asn Pro Tyr Gly Phe Thr Val 
        835                 840                 845             


Ser Trp Met Ala Ser Glu Asn Ala Phe Asp Ser Phe Leu Val Thr Val 
    850                 855                 860                 


Val Asp Ser Gly Lys Leu Leu Asp Pro Gln Glu Phe Thr Leu Ser Gly 
865                 870                 875                 880 


Thr Gln Arg Lys Leu Glu Leu Arg Gly Leu Ile Thr Gly Ile Gly Tyr 
                885                 890                 895     


Glu Val Met Val Ser Gly Phe Thr Gln Gly His Gln Thr Lys Pro Leu 
            900                 905                 910         


Arg Ala Glu Ile Val Thr Glu Ala Met Gly Ser Pro Lys Glu Val Ile 
        915                 920                 925             


Phe Ser Asp Ile Thr Glu Asn Ser Ala Thr Val Ser Trp Arg Ala Pro 
    930                 935                 940                 


Thr Ala Gln Val Glu Ser Phe Arg Ile Thr Tyr Val Pro Ile Thr Gly 
945                 950                 955                 960 


Gly Thr Pro Ser Met Val Thr Val Asp Gly Thr Lys Thr Gln Thr Arg 
                965                 970                 975     


Leu Val Lys Leu Ile Pro Gly Val Glu Tyr Leu Val Ser Ile Ile Ala 
            980                 985                 990         


Met Lys Gly Phe Glu Glu Ser Glu  Pro Val Ser Gly Ser  Phe Thr Thr 
        995                 1000                 1005             


Ala Ser  Gly Leu Asn Asp Ile  Phe Glu Ala Gln Lys  Ile Glu Trp 
    1010                 1015                 1020             


His Glu  Gly Thr His His His  His His His 
    1025                 1030             


<210>  8
<211>  941
<212>  PRT
<213>  Artificial sequence

<220>
<223>  GST huTNCfn5 mu A124 BC hu fn6 B

<400>  8

Met Ser Pro Ile Leu Gly Tyr Trp Lys Ile Lys Gly Leu Val Gln Pro 
1               5                   10                  15      


Thr Arg Leu Leu Leu Glu Tyr Leu Glu Glu Lys Tyr Glu Glu His Leu 
            20                  25                  30          


Tyr Glu Arg Asp Glu Gly Asp Lys Trp Arg Asn Lys Lys Phe Glu Leu 
        35                  40                  45              


Gly Leu Glu Phe Pro Asn Leu Pro Tyr Tyr Ile Asp Gly Asp Val Lys 
    50                  55                  60                  


Leu Thr Gln Ser Met Ala Ile Ile Arg Tyr Ile Ala Asp Lys His Asn 
65                  70                  75                  80  


Met Leu Gly Gly Cys Pro Lys Glu Arg Ala Glu Ile Ser Met Leu Glu 
                85                  90                  95      


Gly Ala Val Leu Asp Ile Arg Tyr Gly Val Ser Arg Ile Ala Tyr Ser 
            100                 105                 110         


Lys Asp Phe Glu Thr Leu Lys Val Asp Phe Leu Ser Lys Leu Pro Glu 
        115                 120                 125             


Met Leu Lys Met Phe Glu Asp Arg Leu Cys His Lys Thr Tyr Leu Asn 
    130                 135                 140                 


Gly Asp His Val Thr His Pro Asp Phe Met Leu Tyr Asp Ala Leu Asp 
145                 150                 155                 160 


Val Val Leu Tyr Met Asp Pro Met Cys Leu Asp Ala Phe Pro Lys Leu 
                165                 170                 175     


Val Cys Phe Lys Lys Arg Ile Glu Ala Ile Pro Gln Ile Asp Lys Tyr 
            180                 185                 190         


Leu Lys Ser Ser Lys Tyr Ile Ala Trp Pro Leu Gln Gly Trp Gln Ala 
        195                 200                 205             


Thr Phe Gly Gly Gly Asp His Pro Pro Lys Ser Asp Gly Ser Thr Ser 
    210                 215                 220                 


Gly Ser Gly His His His His His His Ser Ala Gly Leu Val Pro Arg 
225                 230                 235                 240 


Gly Ser Thr Ala Ile Gly Met Lys Glu Thr Ala Ala Ala Lys Phe Glu 
                245                 250                 255     


Arg Gln His Met Asp Ser Pro Asp Leu Gly Thr Gly Gly Gly Ser Gly 
            260                 265                 270         


Ile Glu Gly Arg Gly Ser Met Gly Tyr Arg Gly Ser Glu Leu Asp Thr 
        275                 280                 285             


Pro Lys Asp Leu Gln Val Ser Glu Thr Ala Glu Thr Ser Leu Thr Leu 
    290                 295                 300                 


Leu Trp Lys Thr Pro Leu Ala Lys Phe Asp Arg Tyr Arg Leu Asn Tyr 
305                 310                 315                 320 


Ser Leu Pro Thr Gly Gln Trp Val Gly Val Gln Leu Pro Arg Asn Thr 
                325                 330                 335     


Thr Ser Tyr Val Leu Arg Gly Leu Glu Pro Gly Gln Glu Tyr Asn Val 
            340                 345                 350         


Leu Leu Thr Ala Glu Lys Gly Arg His Lys Ser Lys Pro Ala Arg Val 
        355                 360                 365             


Lys Ala Ser Thr Glu Glu Val Pro Ser Leu Glu Asn Leu Thr Val Thr 
    370                 375                 380                 


Glu Ala Gly Trp Asp Gly Leu Arg Leu Asn Trp Thr Ala Asp Asp Leu 
385                 390                 395                 400 


Ala Tyr Glu Tyr Phe Val Ile Gln Val Gln Glu Ala Asn Asn Val Glu 
                405                 410                 415     


Thr Ala His Asn Phe Thr Val Pro Gly Asn Leu Arg Ala Ala Asp Ile 
            420                 425                 430         


Pro Gly Leu Lys Val Ala Thr Ser Tyr Arg Val Ser Ile Tyr Gly Val 
        435                 440                 445             


Ala Arg Gly Tyr Arg Thr Pro Val Leu Ser Ala Glu Thr Ser Thr Gly 
    450                 455                 460                 


Thr Thr Pro Asn Leu Gly Glu Val Thr Val Ala Glu Val Gly Trp Asp 
465                 470                 475                 480 


Ala Leu Thr Leu Asn Trp Thr Ala Pro Glu Gly Ala Tyr Lys Asn Phe 
                485                 490                 495     


Phe Ile Gln Val Leu Glu Ala Asp Thr Thr Gln Thr Val Gln Asn Leu 
            500                 505                 510         


Thr Val Pro Gly Gly Leu Arg Ser Val Asp Leu Pro Gly Leu Lys Ala 
        515                 520                 525             


Ala Thr Arg Tyr Tyr Ile Thr Leu Arg Gly Val Thr Gln Asp Phe Gly 
    530                 535                 540                 


Thr Ala Pro Leu Ser Val Glu Val Leu Thr Glu Asp Leu Pro Gln Leu 
545                 550                 555                 560 


Gly Gly Leu Ser Val Thr Glu Val Ser Trp Asp Gly Leu Thr Leu Asn 
                565                 570                 575     


Trp Thr Thr Asp Asp Leu Ala Tyr Lys His Phe Val Val Gln Val Gln 
            580                 585                 590         


Glu Ala Asn Asn Val Glu Ala Ala Gln Asn Leu Thr Val Pro Gly Ser 
        595                 600                 605             


Leu Arg Ala Val Asp Ile Pro Gly Leu Lys Ala Asp Thr Pro Tyr Arg 
    610                 615                 620                 


Val Ser Ile Tyr Gly Val Ile Gln Gly Tyr Arg Thr Pro Met Leu Ser 
625                 630                 635                 640 


Thr Asp Val Ser Thr Ala Arg Glu Pro Glu Ile Gly Asn Leu Asn Val 
                645                 650                 655     


Ser Asp Val Thr Pro Lys Ser Phe Asn Leu Ser Trp Thr Ala Thr Asp 
            660                 665                 670         


Gly Ile Phe Asp Met Phe Thr Ile Glu Ile Ile Asp Ser Asn Arg Leu 
        675                 680                 685             


Leu Gln Thr Ala Glu His Asn Ile Ser Gly Ala Glu Arg Thr Ala His 
    690                 695                 700                 


Ile Ser Gly Leu Pro Pro Ser Thr Asp Phe Ile Val Tyr Leu Ser Gly 
705                 710                 715                 720 


Ile Ala Pro Ser Ile Arg Thr Lys Thr Ile Ser Thr Thr Ala Thr Thr 
                725                 730                 735     


Glu Ala Leu Pro Leu Leu Glu Asn Leu Thr Ile Ser Asp Thr Asn Pro 
            740                 745                 750         


Tyr Gly Phe Thr Val Ser Trp Thr Ala Ser Glu Asn Ala Phe Asp Ser 
        755                 760                 765             


Phe Leu Val Thr Val Val Asp Ser Gly Lys Leu Leu Asp Pro Gln Glu 
    770                 775                 780                 


Phe Thr Leu Ser Gly Thr Gln Arg Lys Leu Glu Leu Arg Gly Leu Ile 
785                 790                 795                 800 


Thr Gly Ile Gly Tyr Glu Val Leu Val Ser Gly Phe Thr Gln Gly His 
                805                 810                 815     


Gln Thr Lys Pro Leu Arg Ala Glu Thr Ile Thr Ala Met Gly Ser Pro 
            820                 825                 830         


Lys Glu Val Ile Phe Ser Asp Ile Thr Glu Asn Ser Ala Thr Val Ser 
        835                 840                 845             


Trp Arg Ala Pro Thr Ala Gln Val Glu Ser Phe Arg Ile Thr Tyr Val 
    850                 855                 860                 


Pro Ile Thr Gly Gly Thr Pro Ser Met Val Thr Val Asp Gly Thr Lys 
865                 870                 875                 880 


Thr Gln Thr Arg Leu Val Lys Leu Ile Pro Gly Val Glu Tyr Leu Val 
                885                 890                 895     


Ser Ile Ile Ala Met Lys Gly Phe Glu Glu Ser Glu Pro Val Ser Gly 
            900                 905                 910         


Ser Phe Thr Thr Ala Ser Gly Leu Asn Asp Ile Phe Glu Ala Gln Lys 
        915                 920                 925             


Ile Glu Trp His Glu Gly Thr His His His His His His 
    930                 935                 940     


<210>  9
<211>  668
<212>  PRT
<213>  Artificial sequence

<220>
<223>  GST TNC hu fn5 B-C fn6 B

<400>  9

Met Ser Pro Ile Leu Gly Tyr Trp Lys Ile Lys Gly Leu Val Gln Pro 
1               5                   10                  15      


Thr Arg Leu Leu Leu Glu Tyr Leu Glu Glu Lys Tyr Glu Glu His Leu 
            20                  25                  30          


Tyr Glu Arg Asp Glu Gly Asp Lys Trp Arg Asn Lys Lys Phe Glu Leu 
        35                  40                  45              


Gly Leu Glu Phe Pro Asn Leu Pro Tyr Tyr Ile Asp Gly Asp Val Lys 
    50                  55                  60                  


Leu Thr Gln Ser Met Ala Ile Ile Arg Tyr Ile Ala Asp Lys His Asn 
65                  70                  75                  80  


Met Leu Gly Gly Cys Pro Lys Glu Arg Ala Glu Ile Ser Met Leu Glu 
                85                  90                  95      


Gly Ala Val Leu Asp Ile Arg Tyr Gly Val Ser Arg Ile Ala Tyr Ser 
            100                 105                 110         


Lys Asp Phe Glu Thr Leu Lys Val Asp Phe Leu Ser Lys Leu Pro Glu 
        115                 120                 125             


Met Leu Lys Met Phe Glu Asp Arg Leu Cys His Lys Thr Tyr Leu Asn 
    130                 135                 140                 


Gly Asp His Val Thr His Pro Asp Phe Met Leu Tyr Asp Ala Leu Asp 
145                 150                 155                 160 


Val Val Leu Tyr Met Asp Pro Met Cys Leu Asp Ala Phe Pro Lys Leu 
                165                 170                 175     


Val Cys Phe Lys Lys Arg Ile Glu Ala Ile Pro Gln Ile Asp Lys Tyr 
            180                 185                 190         


Leu Lys Ser Ser Lys Tyr Ile Ala Trp Pro Leu Gln Gly Trp Gln Ala 
        195                 200                 205             


Thr Phe Gly Gly Gly Asp His Pro Pro Lys Ser Asp Gly Ser Thr Ser 
    210                 215                 220                 


Gly Ser Gly His His His His His His Ser Ala Gly Leu Val Pro Arg 
225                 230                 235                 240 


Gly Ser Thr Ala Ile Gly Met Lys Glu Thr Ala Ala Ala Lys Phe Glu 
                245                 250                 255     


Arg Gln His Met Asp Ser Pro Asp Leu Gly Thr Gly Gly Gly Ser Gly 
            260                 265                 270         


Ile Glu Gly Arg Gly Ser Met Gly Tyr Arg Gly Ser Glu Leu Asp Thr 
        275                 280                 285             


Pro Lys Asp Leu Gln Val Ser Glu Thr Ala Glu Thr Ser Leu Thr Leu 
    290                 295                 300                 


Leu Trp Lys Thr Pro Leu Ala Lys Phe Asp Arg Tyr Arg Leu Asn Tyr 
305                 310                 315                 320 


Ser Leu Pro Thr Gly Gln Trp Val Gly Val Gln Leu Pro Arg Asn Thr 
                325                 330                 335     


Thr Ser Tyr Val Leu Arg Gly Leu Glu Pro Gly Gln Glu Tyr Asn Val 
            340                 345                 350         


Leu Leu Thr Ala Glu Lys Gly Arg His Lys Ser Lys Pro Ala Arg Val 
        355                 360                 365             


Lys Ala Ser Thr Ala Lys Glu Pro Glu Ile Gly Asn Leu Asn Val Ser 
    370                 375                 380                 


Asp Ile Thr Pro Glu Ser Phe Asn Leu Ser Trp Met Ala Thr Asp Gly 
385                 390                 395                 400 


Ile Phe Glu Thr Phe Thr Ile Glu Ile Ile Asp Ser Asn Arg Leu Leu 
                405                 410                 415     


Glu Thr Val Glu Tyr Asn Ile Ser Gly Ala Glu Arg Thr Ala His Ile 
            420                 425                 430         


Ser Gly Leu Pro Pro Ser Thr Asp Phe Ile Val Tyr Leu Ser Gly Leu 
        435                 440                 445             


Ala Pro Ser Ile Arg Thr Lys Thr Ile Ser Ala Thr Ala Thr Thr Glu 
    450                 455                 460                 


Ala Leu Pro Leu Leu Glu Asn Leu Thr Ile Ser Asp Ile Asn Pro Tyr 
465                 470                 475                 480 


Gly Phe Thr Val Ser Trp Met Ala Ser Glu Asn Ala Phe Asp Ser Phe 
                485                 490                 495     


Leu Val Thr Val Val Asp Ser Gly Lys Leu Leu Asp Pro Gln Glu Phe 
            500                 505                 510         


Thr Leu Ser Gly Thr Gln Arg Lys Leu Glu Leu Arg Gly Leu Ile Thr 
        515                 520                 525             


Gly Ile Gly Tyr Glu Val Met Val Ser Gly Phe Thr Gln Gly His Gln 
    530                 535                 540                 


Thr Lys Pro Leu Arg Ala Glu Ile Val Thr Ala Met Gly Ser Pro Lys 
545                 550                 555                 560 


Glu Val Ile Phe Ser Asp Ile Thr Glu Asn Ser Ala Thr Val Ser Trp 
                565                 570                 575     


Arg Ala Pro Thr Ala Gln Val Glu Ser Phe Arg Ile Thr Tyr Val Pro 
            580                 585                 590         


Ile Thr Gly Gly Thr Pro Ser Met Val Thr Val Asp Gly Thr Lys Thr 
        595                 600                 605             


Gln Thr Arg Leu Val Lys Leu Ile Pro Gly Val Glu Tyr Leu Val Ser 
    610                 615                 620                 


Ile Ile Ala Met Lys Gly Phe Glu Glu Ser Glu Pro Val Ser Gly Ser 
625                 630                 635                 640 


Phe Thr Thr Ala Ser Gly Leu Asn Asp Ile Phe Glu Ala Gln Lys Ile 
                645                 650                 655     


Glu Trp His Glu Gly Thr His His His His His His 
            660                 665             


<210>  10
<211>  853
<212>  PRT
<213>  Artificial sequence

<220>
<223>  GST huTNC fn5 A1234 fn6 B

<400>  10

Met Ser Pro Ile Leu Gly Tyr Trp Lys Ile Lys Gly Leu Val Gln Pro 
1               5                   10                  15      


Thr Arg Leu Leu Leu Glu Tyr Leu Glu Glu Lys Tyr Glu Glu His Leu 
            20                  25                  30          


Tyr Glu Arg Asp Glu Gly Asp Lys Trp Arg Asn Lys Lys Phe Glu Leu 
        35                  40                  45              


Gly Leu Glu Phe Pro Asn Leu Pro Tyr Tyr Ile Asp Gly Asp Val Lys 
    50                  55                  60                  


Leu Thr Gln Ser Met Ala Ile Ile Arg Tyr Ile Ala Asp Lys His Asn 
65                  70                  75                  80  


Met Leu Gly Gly Cys Pro Lys Glu Arg Ala Glu Ile Ser Met Leu Glu 
                85                  90                  95      


Gly Ala Val Leu Asp Ile Arg Tyr Gly Val Ser Arg Ile Ala Tyr Ser 
            100                 105                 110         


Lys Asp Phe Glu Thr Leu Lys Val Asp Phe Leu Ser Lys Leu Pro Glu 
        115                 120                 125             


Met Leu Lys Met Phe Glu Asp Arg Leu Cys His Lys Thr Tyr Leu Asn 
    130                 135                 140                 


Gly Asp His Val Thr His Pro Asp Phe Met Leu Tyr Asp Ala Leu Asp 
145                 150                 155                 160 


Val Val Leu Tyr Met Asp Pro Met Cys Leu Asp Ala Phe Pro Lys Leu 
                165                 170                 175     


Val Cys Phe Lys Lys Arg Ile Glu Ala Ile Pro Gln Ile Asp Lys Tyr 
            180                 185                 190         


Leu Lys Ser Ser Lys Tyr Ile Ala Trp Pro Leu Gln Gly Trp Gln Ala 
        195                 200                 205             


Thr Phe Gly Gly Gly Asp His Pro Pro Lys Ser Asp Gly Ser Thr Ser 
    210                 215                 220                 


Gly Ser Gly His His His His His His Ser Ala Gly Leu Val Pro Arg 
225                 230                 235                 240 


Gly Ser Thr Ala Ile Gly Met Lys Glu Thr Ala Ala Ala Lys Phe Glu 
                245                 250                 255     


Arg Gln His Met Asp Ser Pro Asp Leu Gly Thr Gly Gly Gly Ser Gly 
            260                 265                 270         


Ile Glu Gly Arg Gly Ser Met Gly Tyr Arg Gly Ser Glu Leu Asp Thr 
        275                 280                 285             


Pro Lys Asp Leu Gln Val Ser Glu Thr Ala Glu Thr Ser Leu Thr Leu 
    290                 295                 300                 


Leu Trp Lys Thr Pro Leu Ala Lys Phe Asp Arg Tyr Arg Leu Asn Tyr 
305                 310                 315                 320 


Ser Leu Pro Thr Gly Gln Trp Val Gly Val Gln Leu Pro Arg Asn Thr 
                325                 330                 335     


Thr Ser Tyr Val Leu Arg Gly Leu Glu Pro Gly Gln Glu Tyr Asn Val 
            340                 345                 350         


Leu Leu Thr Ala Glu Lys Gly Arg His Lys Ser Lys Pro Ala Arg Val 
        355                 360                 365             


Lys Ala Ser Thr Glu Gln Ala Pro Glu Leu Glu Asn Leu Thr Val Thr 
    370                 375                 380                 


Glu Val Gly Trp Asp Gly Leu Arg Leu Asn Trp Thr Ala Ala Asp Gln 
385                 390                 395                 400 


Ala Tyr Glu His Phe Ile Ile Gln Val Gln Glu Ala Asn Lys Val Glu 
                405                 410                 415     


Ala Ala Arg Asn Leu Thr Val Pro Gly Ser Leu Arg Ala Val Asp Ile 
            420                 425                 430         


Pro Gly Leu Lys Ala Ala Thr Pro Tyr Thr Val Ser Ile Tyr Gly Val 
        435                 440                 445             


Ile Gln Gly Tyr Arg Thr Pro Val Leu Ser Ala Glu Ala Ser Thr Gly 
    450                 455                 460                 


Glu Thr Pro Asn Leu Gly Glu Val Val Val Ala Glu Val Gly Trp Asp 
465                 470                 475                 480 


Ala Leu Lys Leu Asn Trp Thr Ala Pro Glu Gly Ala Tyr Glu Tyr Phe 
                485                 490                 495     


Phe Ile Gln Val Gln Glu Ala Asp Thr Val Glu Ala Ala Gln Asn Leu 
            500                 505                 510         


Thr Val Pro Gly Gly Leu Arg Ser Thr Asp Leu Pro Gly Leu Lys Ala 
        515                 520                 525             


Ala Thr His Tyr Thr Ile Thr Ile Arg Gly Val Thr Gln Asp Phe Ser 
    530                 535                 540                 


Thr Thr Pro Leu Ser Val Glu Val Leu Thr Glu Glu Val Pro Asp Met 
545                 550                 555                 560 


Gly Asn Leu Thr Val Thr Glu Val Ser Trp Asp Ala Leu Arg Leu Asn 
                565                 570                 575     


Trp Thr Thr Pro Asp Gly Thr Tyr Asp Gln Phe Thr Ile Gln Val Gln 
            580                 585                 590         


Glu Ala Asp Gln Val Glu Glu Ala His Asn Leu Thr Val Pro Gly Ser 
        595                 600                 605             


Leu Arg Ser Met Glu Ile Pro Gly Leu Arg Ala Gly Thr Pro Tyr Thr 
    610                 615                 620                 


Val Thr Leu His Gly Glu Val Arg Gly His Ser Thr Arg Pro Leu Ala 
625                 630                 635                 640 


Val Glu Val Val Thr Glu Asp Leu Pro Gln Leu Gly Asp Leu Ala Val 
                645                 650                 655     


Ser Glu Val Gly Trp Asp Gly Leu Arg Leu Asn Trp Thr Ala Ala Asp 
            660                 665                 670         


Asn Ala Tyr Glu His Phe Val Ile Gln Val Gln Glu Val Asn Lys Val 
        675                 680                 685             


Glu Ala Ala Gln Asn Leu Thr Leu Pro Gly Ser Leu Arg Ala Val Asp 
    690                 695                 700                 


Ile Pro Gly Leu Glu Ala Ala Thr Pro Tyr Arg Val Ser Ile Tyr Gly 
705                 710                 715                 720 


Val Ile Arg Gly Tyr Arg Thr Pro Val Leu Ser Ala Glu Ala Ser Thr 
                725                 730                 735     


Ala Lys Glu Ala Met Gly Ser Pro Lys Glu Val Ile Phe Ser Asp Ile 
            740                 745                 750         


Thr Glu Asn Ser Ala Thr Val Ser Trp Arg Ala Pro Thr Ala Gln Val 
        755                 760                 765             


Glu Ser Phe Arg Ile Thr Tyr Val Pro Ile Thr Gly Gly Thr Pro Ser 
    770                 775                 780                 


Met Val Thr Val Asp Gly Thr Lys Thr Gln Thr Arg Leu Val Lys Leu 
785                 790                 795                 800 


Ile Pro Gly Val Glu Tyr Leu Val Ser Ile Ile Ala Met Lys Gly Phe 
                805                 810                 815     


Glu Glu Ser Glu Pro Val Ser Gly Ser Phe Thr Thr Ala Ser Gly Leu 
            820                 825                 830         


Asn Asp Ile Phe Glu Ala Gln Lys Ile Glu Trp His Glu Gly Thr His 
        835                 840                 845             


His His His His His 
    850             


<210>  11
<211>  400
<212>  PRT
<213>  Artificial sequence

<220>
<223>  huTNC A4 B

<400>  11

Met Ser Pro Ile Leu Gly Tyr Trp Lys Ile Lys Gly Leu Val Gln Pro 
1               5                   10                  15      


Thr Arg Leu Leu Leu Glu Tyr Leu Glu Glu Lys Tyr Glu Glu His Leu 
            20                  25                  30          


Tyr Glu Arg Asp Glu Gly Asp Lys Trp Arg Asn Lys Lys Phe Glu Leu 
        35                  40                  45              


Gly Leu Glu Phe Pro Asn Leu Pro Tyr Tyr Ile Asp Gly Asp Val Lys 
    50                  55                  60                  


Leu Thr Gln Ser Met Ala Ile Ile Arg Tyr Ile Ala Asp Lys His Asn 
65                  70                  75                  80  


Met Leu Gly Gly Cys Pro Lys Glu Arg Ala Glu Ile Ser Met Leu Glu 
                85                  90                  95      


Gly Ala Val Leu Asp Ile Arg Tyr Gly Val Ser Arg Ile Ala Tyr Ser 
            100                 105                 110         


Lys Asp Phe Glu Thr Leu Lys Val Asp Phe Leu Ser Lys Leu Pro Glu 
        115                 120                 125             


Met Leu Lys Met Phe Glu Asp Arg Leu Cys His Lys Thr Tyr Leu Asn 
    130                 135                 140                 


Gly Asp His Val Thr His Pro Asp Phe Met Leu Tyr Asp Ala Leu Asp 
145                 150                 155                 160 


Val Val Leu Tyr Met Asp Pro Met Cys Leu Asp Ala Phe Pro Lys Leu 
                165                 170                 175     


Val Cys Phe Lys Lys Arg Ile Glu Ala Ile Pro Gln Ile Asp Lys Tyr 
            180                 185                 190         


Leu Lys Ser Ser Lys Tyr Ile Ala Trp Pro Leu Gln Gly Trp Gln Ala 
        195                 200                 205             


Thr Phe Gly Gly Gly Asp His Pro Pro Lys Ser Asp Gly Ser Thr Ser 
    210                 215                 220                 


Gly Ser Gly His His His His His His Ser Ala Gly Leu Val Pro Arg 
225                 230                 235                 240 


Gly Ser Thr Ala Ile Gly Met Lys Glu Thr Ala Ala Ala Lys Phe Glu 
                245                 250                 255     


Arg Gln His Met Asp Ser Pro Asp Leu Gly Thr Gly Gly Gly Ser Gly 
            260                 265                 270         


Ile Glu Gly Arg Gly Ser Met Gly Tyr Arg Gly Ser Glu Asp Leu Pro 
        275                 280                 285             


Gln Leu Gly Asp Leu Ala Val Ser Glu Val Gly Trp Asp Gly Leu Arg 
    290                 295                 300                 


Leu Asn Trp Thr Ala Ala Asp Asn Ala Tyr Glu His Phe Val Ile Gln 
305                 310                 315                 320 


Val Gln Glu Val Asn Lys Val Glu Ala Ala Gln Asn Leu Thr Leu Pro 
                325                 330                 335     


Gly Ser Leu Arg Ala Val Asp Ile Pro Gly Leu Glu Ala Ala Thr Pro 
            340                 345                 350         


Tyr Arg Val Ser Ile Tyr Gly Val Ile Arg Gly Tyr Arg Thr Pro Val 
        355                 360                 365             


Leu Ser Ala Glu Ala Ser Thr Ala Ser Gly Leu Asn Asp Ile Phe Glu 
    370                 375                 380                 


Ala Gln Lys Ile Glu Trp His Glu Gly Thr His His His His His His 
385                 390                 395                 400 


<210>  12
<211>  400
<212>  PRT
<213>  Artificial sequence

<220>
<223>  huTNC A1 B

<400>  12

Met Ser Pro Ile Leu Gly Tyr Trp Lys Ile Lys Gly Leu Val Gln Pro 
1               5                   10                  15      


Thr Arg Leu Leu Leu Glu Tyr Leu Glu Glu Lys Tyr Glu Glu His Leu 
            20                  25                  30          


Tyr Glu Arg Asp Glu Gly Asp Lys Trp Arg Asn Lys Lys Phe Glu Leu 
        35                  40                  45              


Gly Leu Glu Phe Pro Asn Leu Pro Tyr Tyr Ile Asp Gly Asp Val Lys 
    50                  55                  60                  


Leu Thr Gln Ser Met Ala Ile Ile Arg Tyr Ile Ala Asp Lys His Asn 
65                  70                  75                  80  


Met Leu Gly Gly Cys Pro Lys Glu Arg Ala Glu Ile Ser Met Leu Glu 
                85                  90                  95      


Gly Ala Val Leu Asp Ile Arg Tyr Gly Val Ser Arg Ile Ala Tyr Ser 
            100                 105                 110         


Lys Asp Phe Glu Thr Leu Lys Val Asp Phe Leu Ser Lys Leu Pro Glu 
        115                 120                 125             


Met Leu Lys Met Phe Glu Asp Arg Leu Cys His Lys Thr Tyr Leu Asn 
    130                 135                 140                 


Gly Asp His Val Thr His Pro Asp Phe Met Leu Tyr Asp Ala Leu Asp 
145                 150                 155                 160 


Val Val Leu Tyr Met Asp Pro Met Cys Leu Asp Ala Phe Pro Lys Leu 
                165                 170                 175     


Val Cys Phe Lys Lys Arg Ile Glu Ala Ile Pro Gln Ile Asp Lys Tyr 
            180                 185                 190         


Leu Lys Ser Ser Lys Tyr Ile Ala Trp Pro Leu Gln Gly Trp Gln Ala 
        195                 200                 205             


Thr Phe Gly Gly Gly Asp His Pro Pro Lys Ser Asp Gly Ser Thr Ser 
    210                 215                 220                 


Gly Ser Gly His His His His His His Ser Ala Gly Leu Val Pro Arg 
225                 230                 235                 240 


Gly Ser Thr Ala Ile Gly Met Lys Glu Thr Ala Ala Ala Lys Phe Glu 
                245                 250                 255     


Arg Gln His Met Asp Ser Pro Asp Leu Gly Thr Gly Gly Gly Ser Gly 
            260                 265                 270         


Ile Glu Gly Arg Gly Ser Met Gly Tyr Arg Gly Ser Glu Gln Ala Pro 
        275                 280                 285             


Glu Leu Glu Asn Leu Thr Val Thr Glu Val Gly Trp Asp Gly Leu Arg 
    290                 295                 300                 


Leu Asn Trp Thr Ala Ala Asp Gln Ala Tyr Glu His Phe Ile Ile Gln 
305                 310                 315                 320 


Val Gln Glu Ala Asn Lys Val Glu Ala Ala Arg Asn Leu Thr Val Pro 
                325                 330                 335     


Gly Ser Leu Arg Ala Val Asp Ile Pro Gly Leu Lys Ala Ala Thr Pro 
            340                 345                 350         


Tyr Thr Val Ser Ile Tyr Gly Val Ile Gln Gly Tyr Arg Thr Pro Val 
        355                 360                 365             


Leu Ser Ala Glu Ala Ser Thr Ala Ser Gly Leu Asn Asp Ile Phe Glu 
    370                 375                 380                 


Ala Gln Lys Ile Glu Trp His Glu Gly Thr His His His His His His 
385                 390                 395                 400 


<210>  13
<211>  1614
<212>  DNA
<213>  Artificial sequence

<220>
<223>  pRJH33 library template DP88-4 library; complete Fab coding 
       region comprising PelB leader sequence + Vk1_5 kappa V-domain + 
       CL constant domain for light chain and PelB + VH1_69 V-domain + 
       CH1 constant domain for heavy chain)

<400>  13
atgaaatacc tattgcctac ggcagccgct ggattgttat tactcgcggc ccagccggcc       60

atggccgaca tccagatgac ccagtctcct tccaccctgt ctgcatctgt aggagaccgt      120

gtcaccatca cttgccgtgc cagtcagagt attagtagct ggttggcctg gtatcagcag      180

aaaccaggga aagcccctaa gctcctgatc tatgatgcct ccagtttgga aagtggggtc      240

ccatcacgtt tcagcggcag tggatccggg acagaattca ctctcaccat cagcagcttg      300

cagcctgatg attttgcaac ttattactgc caacagtata atagttattc tacgtttggc      360

cagggcacca aagtcgagat caagcgtacg gtggctgcac catctgtctt catcttcccg      420

ccatctgatg agcagttgaa atctggaact gcctctgttg tgtgcctgct gaataacttc      480

tatcccagag aggccaaagt acagtggaag gtggataacg ccctccaatc gggtaactcc      540

caggagagtg tcacagagca ggacagcaag gacagcacct acagcctcag cagcaccctg      600

acgctgagca aagcagacta cgagaaacac aaagtctacg cctgcgaagt cacccatcag      660

ggcctgagct cgcccgtcac aaagagcttc aacaggggag agtgtggagc cgcagaacaa      720

aaactcatct cagaagagga tctgaatgga gccgcagact acaaggacga cgacgacaag      780

ggtgccgcat aataaggcgc gccaattcta tttcaaggag acagtcatat gaaatacctg      840

ctgccgaccg ctgctgctgg tctgctgctc ctcgctgccc agccggcgat ggcccaggtg      900

caattggtgc agtctggggc tgaggtgaag aagcctgggt cctcggtgaa ggtctcctgc      960

aaggcctccg gaggcacatt cagcagctac gctataagct gggtgcgaca ggcccctgga     1020

caagggctcg agtggatggg agggatcatc cctatctttg gtacagcaaa ctacgcacag     1080

aagttccagg gcagggtcac cattactgca gacaaatcca cgagcacagc ctacatggag     1140

ctgagcagcc tgagatctga ggacaccgcc gtgtattact gtgcgagact atccccaggc     1200

ggttactatg ttatggatgc ctggggccaa gggaccaccg tgaccgtctc ctcagctagc     1260

accaaaggcc catcggtctt ccccctggca ccctcctcca agagcacctc tgggggcaca     1320

gcggccctgg gctgcctggt caaggactac ttccccgaac cggtgacggt gtcgtggaac     1380

tcaggcgccc tgaccagcgg cgtgcacacc ttcccggctg tcctacagtc ctcaggactc     1440

tactccctca gcagcgtggt gaccgtgccc tccagcagct tgggcaccca gacctacatc     1500

tgcaacgtga atcacaagcc cagcaacacc aaagtggaca agaaagttga gcccaaatct     1560

tgtgacgcgg ccgcaagcac tagtgcccat caccatcacc atcacgccgc ggca           1614


<210>  14
<211>  723
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Fab light chain V1_5

<400>  14
gacatccaga tgacccagtc tccttccacc ctgtctgcat ctgtaggaga ccgtgtcacc       60

atcacttgcc gtgccagtca gagtattagt agctggttgg cctggtatca gcagaaacca      120

gggaaagccc ctaagctcct gatctatgat gcctccagtt tggaaagtgg ggtcccatca      180

cgtttcagcg gcagtggatc cgggacagaa ttcactctca ccatcagcag cttgcagcct      240

gatgattttg caacttatta ctgccaacag tataatagtt attctacgtt tggccagggc      300

accaaagtcg agatcaagcg tacggtggct gcaccatctg tcttcatctt cccgccatct      360

gatgagcagt tgaaatctgg aactgcctct gttgtgtgcc tgctgaataa cttctatccc      420

agagaggcca aagtacagtg gaaggtggat aacgccctcc aatcgggtaa ctcccaggag      480

agtgtcacag agcaggacag caaggacagc acctacagcc tcagcagcac cctgacgctg      540

agcaaagcag actacgagaa acacaaagtc tacgcctgcg aagtcaccca tcagggcctg      600

agctcgcccg tcacaaagag cttcaacagg ggagagtgtg gagccgcaga acaaaaactc      660

atctcagaag aggatctgaa tggagccgca gactacaagg acgacgacga caagggtgcc      720

gca                                                                    723


<210>  15
<211>  720
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Fab heavy chain VH1_69

<400>  15
caggtgcaat tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cctccggagg cacattcagc agctacgcta taagctgggt gcgacaggcc      120

cctggacaag ggctcgagtg gatgggaggg atcatcccta tctttggtac agcaaactac      180

gcacagaagt tccagggcag ggtcaccatt actgcagaca aatccacgag cacagcctac      240

atggagctga gcagcctgag atctgaggac accgccgtgt attactgtgc gagactatcc      300

ccaggcggtt actatgttat ggatgcctgg ggccaaggga ccaccgtgac cgtctcctca      360

gctagcacca aaggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg      420

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      480

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      540

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc      600

tacatctgca acgtgaatca caagcccagc aacaccaaag tggacaagaa agttgagccc      660

aaatcttgtg acgcggccgc aagcactagt gcccatcacc atcaccatca cgccgcggca      720


<210>  16
<211>  230
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Fab light chain Vk1_5

<400>  16

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Ser Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala Pro 
            100                 105                 110         


Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr 
        115                 120                 125             


Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys 
    130                 135                 140                 


Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu 
145                 150                 155                 160 


Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser 
                165                 170                 175     


Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala 
            180                 185                 190         


Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe 
        195                 200                 205             


Asn Arg Gly Glu Cys Gly Ala Ala Glu Gln Lys Leu Ile Ser Glu Glu 
    210                 215                 220                 


Asp Leu Asn Gly Ala Ala 
225                 230 


<210>  17
<211>  240
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Fab heavy chain VH1_69 (DP88)

<400>  17

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Ser Pro Gly Gly Tyr Tyr Val Met Asp Ala Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Ala Ala Ala Ser Thr Ser Ala His His His His His His Ala Ala Ala 
225                 230                 235                 240 


<210>  18
<211>  26
<212>  DNA
<213>  Artificial sequence

<220>
<223>  LMB3

<400>  18
caggaaacag ctatgaccat gattac                                            26


<210>  19
<211>  71
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Vk1_5_L3r_S


<220>
<221>  misc_feature
<222>  (28)..(28)
<223>  60% given sequence and 40% M

<220>
<221>  misc_feature
<222>  (29)..(30)
<223>  60% given sequence and 40% N

<220>
<221>  misc_feature
<222>  (31)..(31)
<223>  60% given sequence and 40% M

<220>
<221>  misc_feature
<222>  (32)..(33)
<223>  60% given sequence and 40% N

<220>
<221>  misc_feature
<222>  (34)..(34)
<223>  60% given sequence and 40% M

<220>
<221>  misc_feature
<222>  (35)..(36)
<223>  60% given sequence and 40% N

<220>
<221>  misc_feature
<222>  (37)..(37)
<223>  60% given sequence and 40% M

<220>
<221>  misc_feature
<222>  (38)..(39)
<223>  60% given sequence and 40% N

<220>
<221>  misc_feature
<222>  (40)..(40)
<223>  60% given sequence and 40% M

<220>
<221>  misc_feature
<222>  (41)..(42)
<223>  60% given sequence and 40% N

<400>  19
ctcgactttg gtgccctggc caaacgtsba atacgaatta tactgttggc agtaataagt       60

tgcaaaatca t                                                            71


<210>  20
<211>  74
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Vk1_5_L3r_SY


<220>
<221>  misc_feature
<222>  (28)..(28)
<223>  60% given sequence and 40% M

<220>
<221>  misc_feature
<222>  (29)..(30)
<223>  60% given sequence and 40% N

<220>
<221>  misc_feature
<222>  (31)..(31)
<223>  60% given sequence and 40% M

<220>
<221>  misc_feature
<222>  (32)..(33)
<223>  60% given sequence and 40% N

<220>
<221>  misc_feature
<222>  (34)..(34)
<223>  60% given sequence and 40% M

<220>
<221>  misc_feature
<222>  (35)..(36)
<223>  60% given sequence and 40% N

<220>
<221>  misc_feature
<222>  (37)..(37)
<223>  60% given sequence and 40% M

<220>
<221>  misc_feature
<222>  (38)..(39)
<223>  60% given sequence and 40% N

<220>
<221>  misc_feature
<222>  (40)..(40)
<223>  60% given sequence and 40% M

<220>
<221>  misc_feature
<222>  (41)..(42)
<223>  60% given sequence and 40% N

<220>
<221>  misc_feature
<222>  (43)..(43)
<223>  60% given sequence and 40% M

<220>
<221>  misc_feature
<222>  (44)..(45)
<223>  60% given sequence and 40% N

<400>  20
ctcgactttg gtgccctggc caaacgtmhr sgratacgaa ttatactgtt ggcagtaata       60

agttgcaaaa tcat                                                         74


<210>  21
<211>  77
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Vk1_5_L3r_SPY


<220>
<221>  misc_feature
<222>  (28)..(28)
<223>  60% given sequence and 40% M

<220>
<221>  misc_feature
<222>  (29)..(30)
<223>  60% given sequence and 40% N

<220>
<221>  misc_feature
<222>  (31)..(31)
<223>  60% given sequence and 40% M

<220>
<221>  misc_feature
<222>  (32)..(33)
<223>  60% given sequence and 40% N

<220>
<221>  misc_feature
<222>  (34)..(34)
<223>  60% given sequence and 40% M

<220>
<221>  misc_feature
<222>  (35)..(36)
<223>  60% given sequence and 40% N

<220>
<221>  misc_feature
<222>  (37)..(37)
<223>  60% given sequence and 40% M

<220>
<221>  misc_feature
<222>  (38)..(39)
<223>  60% given sequence and 40% N

<220>
<221>  misc_feature
<222>  (40)..(40)
<223>  60% given sequence and 40% M

<220>
<221>  misc_feature
<222>  (41)..(42)
<223>  60% given sequence and 40% N

<220>
<221>  misc_feature
<222>  (43)..(43)
<223>  60% given sequence and 40% M

<220>
<221>  misc_feature
<222>  (44)..(45)
<223>  60% given sequence and 40% N

<220>
<221>  misc_feature
<222>  (46)..(46)
<223>  60% given sequence and 40% M

<220>
<221>  misc_feature
<222>  (47)..(48)
<223>  60% given sequence and 40% N

<400>  21
ctcgactttg gtgccctggc caaacgtmhh msssgratac gaattatact gttggcagta       60

ataagttgca aaatcat                                                      77


<210>  22
<211>  27
<212>  DNA
<213>  Artificial sequence

<220>
<223>  RJH31

<400>  22
acgtttggcc agggcaccaa agtcgag                                           27


<210>  23
<211>  28
<212>  DNA
<213>  Artificial sequence

<220>
<223>  RJH32

<400>  23
tctcgcacag taatacacgg cggtgtcc                                          28


<210>  24
<211>  69
<212>  DNA
<213>  Artificial sequence

<220>
<223>  DP88-v4-4


<220>
<221>  misc_feature
<222>  (29)..(29)
<223>  G/D = 20%, E/V/S = 10%, A/P/R/L/T/Y=5%

<220>
<221>  misc_feature
<222>  (30)..(31)
<223>  G/Y/S=15%, A/D/T/R/P/L/V/N/W/F/I/E = 4,6%

<220>
<221>  misc_feature
<222>  (32)..(32)
<223>  G/A/Y = 20%, P/W/S/D/T = 8%

<220>
<221>  misc_feature
<222>  (33)..(33)
<223>  F = 46%, L/M = 15%, G/I/Y = 8%

<400>  24
ggacaccgcc gtgtattact gtgcgagann nnngactact ggggccaagg gaccaccgtg       60

accgtctcc                                                               69


<210>  25
<211>  71
<212>  DNA
<213>  Artificial sequence

<220>
<223>  DP88-v4-6


<220>
<221>  misc_feature
<222>  (29)..(29)
<223>  G/D = 20%, E/V/S = 10%, A/P/R/L/T/Y=5%

<220>
<221>  misc_feature
<222>  (30)..(33)
<223>  G/Y/S=15%, A/D/T/R/P/L/V/N/W/F/I/E = 4,6%

<220>
<221>  misc_feature
<222>  (34)..(34)
<223>  G/A/Y = 20%, P/W/S/D/T = 8%

<220>
<221>  misc_feature
<222>  (35)..(35)
<223>  F = 46%, L/M = 15%, G/I/Y = 8%

<400>  25
ggacaccgcc gtgtattact gtgcgagann nnnnngacta ctggggccaa gggaccaccg       60

tgaccgtctc c                                                            71


<210>  26
<211>  73
<212>  DNA
<213>  Artificial sequence

<220>
<223>  DP88-v4-8


<220>
<221>  misc_feature
<222>  (29)..(29)
<223>  G/D = 20%, E/V/S = 10%, A/P/R/L/T/Y=5%

<220>
<221>  misc_feature
<222>  (30)..(35)
<223>  G/Y/S=15%, A/D/T/R/P/L/V/N/W/F/I/E = 4,6%

<220>
<221>  misc_feature
<222>  (36)..(36)
<223>  G/A/Y = 20%, P/W/S/D/T = 8%

<220>
<221>  misc_feature
<222>  (37)..(37)
<223>  F = 46%, L/M = 15%, G/I/Y = 8%

<400>  26
ggacaccgcc gtgtattact gtgcgagann nnnnnnngac tactggggcc aagggaccac       60

cgtgaccgtc tcc                                                          73


<210>  27
<211>  30
<212>  DNA
<213>  Artificial sequence

<220>
<223>  fdseqlong

<400>  27
gacgttagta aatgaatttt ctgtatgagg                                        30


<210>  28
<211>  1605
<212>  DNA
<213>  Artificial sequence

<220>
<223>  pRJH53 library template of lambda-DP47 library Vl3_19/VH3_23

<400>  28
atgaaatacc tattgcctac ggcagccgct ggattgttat tactcgcggc ccagccggcc       60

atggcctcgt ctgagctgac tcaggaccct gctgtgtctg tggccttggg acagacagtc      120

aggatcacat gccaaggaga cagcctcaga agttattatg caagctggta ccagcagaag      180

ccaggacagg cccctgtact tgtcatctat ggtaaaaaca accggccctc agggatccca      240

gaccgattct ctggctccag ctcaggaaac acagcttcct tgaccatcac tggggctcag      300

gcggaagatg aggctgacta ttactgtaac tcccgtgata gtagcggtaa tcatgtggta      360

ttcggcggag ggaccaagct gaccgtccta ggacaaccca aggctgcccc cagcgtgacc      420

ctgttccccc ccagcagcga ggaattgcag gccaacaagg ccaccctggt ctgcctgatc      480

agcgacttct acccaggcgc cgtgaccgtg gcctggaagg ccgacagcag ccccgtgaag      540

gccggcgtgg agaccaccac ccccagcaag cagagcaaca acaagtacgc cgccagcagc      600

tacctgagcc tgacccccga gcagtggaag agccacaggt cctacagctg ccaggtgacc      660

cacgagggca gcaccgtgga gaaaaccgtg gcccccaccg agtgcagcgg agccgcagaa      720

caaaaactca tctcagaaga ggatctgaat ggagccgcag actacaagga cgacgacgac      780

aagggtgccg cataataagg cgcgccaatt ctatttcaag gagacagtca tatgaaatac      840

ctgctgccga ccgctgctgc tggtctgctg ctcctcgctg cccagccggc gatggccgag      900

gtgcaattgc tggagtctgg gggaggcttg gtacagcctg gggggtccct gagactctcc      960

tgtgcagcct ccggattcac ctttagcagt tatgccatga gctgggtccg ccaggctcca     1020

gggaaggggc tggagtgggt ctcagctatt agtggtagtg gtggtagcac atactacgca     1080

gactccgtga agggccggtt caccatctcc agagacaatt ccaagaacac gctgtatctg     1140

cagatgaaca gcctgagagc cgaggacacg gccgtatatt actgtgcgaa accgtttccg     1200

tattttgact actggggcca aggaaccctg gtcaccgtct cgagtgctag caccaaaggc     1260

ccatcggtct tccccctggc accctcctcc aagagcacct ctgggggcac agcggccctg     1320

ggctgcctgg tcaaggacta cttccccgaa ccggtgacgg tgtcgtggaa ctcaggcgcc     1380

ctgaccagcg gcgtgcacac cttcccggct gtcctacagt cctcaggact ctactccctc     1440

agcagcgtgg tgaccgtgcc ctccagcagc ttgggcaccc agacctacat ctgcaacgtg     1500

aatcacaagc ccagcaacac caaagtggac aagaaagttg agcccaaatc ttgtgacgcg     1560

gccgcaagca ctagtgccca tcaccatcac catcacgccg cggca                     1605


<210>  29
<211>  726
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Fab light chain Vl3_19

<400>  29
tcgtctgagc tgactcagga ccctgctgtg tctgtggcct tgggacagac agtcaggatc       60

acatgccaag gagacagcct cagaagttat tatgcaagct ggtaccagca gaagccagga      120

caggcccctg tacttgtcat ctatggtaaa aacaaccggc cctcagggat cccagaccga      180

ttctctggct ccagctcagg aaacacagct tccttgacca tcactggggc tcaggcggaa      240

gatgaggctg actattactg taactcccgt gatagtagcg gtaatcatgt ggtattcggc      300

ggagggacca agctgaccgt cctaggacaa cccaaggctg cccccagcgt gaccctgttc      360

ccccccagca gcgaggaatt gcaggccaac aaggccaccc tggtctgcct gatcagcgac      420

ttctacccag gcgccgtgac cgtggcctgg aaggccgaca gcagccccgt gaaggccggc      480

gtggagacca ccacccccag caagcagagc aacaacaagt acgccgccag cagctacctg      540

agcctgaccc ccgagcagtg gaagagccac aggtcctaca gctgccaggt gacccacgag      600

ggcagcaccg tggagaaaac cgtggccccc accgagtgca gcggagccgc agaacaaaaa      660

ctcatctcag aagaggatct gaatggagcc gcagactaca aggacgacga cgacaagggt      720

gccgca                                                                 726


<210>  30
<211>  708
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Fab heavy chain VH3_23

<400>  30
gaggtgcaat tgctggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctccggatt cacctttagc agttatgcca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcagct attagtggta gtggtggtag cacatactac      180

gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcagatga acagcctgag agccgaggac acggccgtat attactgtgc gaaaccgttt      300

ccgtattttg actactgggg ccaaggaacc ctggtcaccg tctcgagtgc tagcaccaaa      360

ggcccatcgg tcttccccct ggcaccctcc tccaagagca cctctggggg cacagcggcc      420

ctgggctgcc tggtcaagga ctacttcccc gaaccggtga cggtgtcgtg gaactcaggc      480

gccctgacca gcggcgtgca caccttcccg gctgtcctac agtcctcagg actctactcc      540

ctcagcagcg tggtgaccgt gccctccagc agcttgggca cccagaccta catctgcaac      600

gtgaatcaca agcccagcaa caccaaagtg gacaagaaag ttgagcccaa atcttgtgac      660

gcggccgcaa gcactagtgc ccatcaccat caccatcacg ccgcggca                   708


<210>  31
<211>  242
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Fab light chain Vl3_19

<400>  31

Ser Ser Glu Leu Thr Gln Asp Pro Ala Val Ser Val Ala Leu Gly Gln 
1               5                   10                  15      


Thr Val Arg Ile Thr Cys Gln Gly Asp Ser Leu Arg Ser Tyr Tyr Ala 
            20                  25                  30          


Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Gly Lys Asn Asn Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser 
    50                  55                  60                  


Ser Ser Gly Asn Thr Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His 
                85                  90                  95      


Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro Lys 
            100                 105                 110         


Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu Gln 
        115                 120                 125             


Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro Gly 
    130                 135                 140                 


Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala Gly 
145                 150                 155                 160 


Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala Ala 
                165                 170                 175     


Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg Ser 
            180                 185                 190         


Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr Val 
        195                 200                 205             


Ala Pro Thr Glu Cys Ser Gly Ala Ala Glu Gln Lys Leu Ile Ser Glu 
    210                 215                 220                 


Glu Asp Leu Asn Gly Ala Ala Asp Tyr Lys Asp Asp Asp Asp Lys Gly 
225                 230                 235                 240 


Ala Ala 
        


<210>  32
<211>  236
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Fab heavy chain VH3_23 (DP47)

<400>  32

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Pro Phe Pro Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
    130                 135                 140                 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
            180                 185                 190         


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
        195                 200                 205             


Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Ala Ala Ala Ser 
    210                 215                 220                 


Thr Ser Ala His His His His His His Ala Ala Ala 
225                 230                 235     


<210>  33
<211>  85
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Vl_3_19_L3r_V


<220>
<221>  misc_feature
<222>  (32)..(32)
<223>  60% original base and 40% randomization as M

<220>
<221>  misc_feature
<222>  (33)..(34)
<223>  60% original base and 40% randomization as N

<220>
<221>  misc_feature
<222>  (35)..(35)
<223>  60% original base and 40% randomization as M

<220>
<221>  misc_feature
<222>  (36)..(37)
<223>  60% original base and 40% randomization as N

<220>
<221>  misc_feature
<222>  (38)..(38)
<223>  60% original base and 40% randomization as M

<220>
<221>  misc_feature
<222>  (39)..(40)
<223>  60% original base and 40% randomization as N

<220>
<221>  misc_feature
<222>  (41)..(41)
<223>  60% original base and 40% randomization as M

<220>
<221>  misc_feature
<222>  (42)..(43)
<223>  60% original base and 40% randomization as N

<220>
<221>  misc_feature
<222>  (44)..(44)
<223>  60% original base and 40% randomization as M

<220>
<221>  misc_feature
<222>  (45)..(46)
<223>  60% original base and 40% randomization as N

<220>
<221>  misc_feature
<222>  (47)..(47)
<223>  60% original base and 40% randomization as M

<220>
<221>  misc_feature
<222>  (48)..(49)
<223>  60% original base and 40% randomization as N

<220>
<221>  misc_feature
<222>  (50)..(50)
<223>  60% original base and 40% randomization as M

<220>
<221>  misc_feature
<222>  (51)..(52)
<223>  60% original base and 40% randomization as N

<400>  33
ggacggtcag cttggtccct ccgccgaata cvhvattacc gctactatca cgggagttac       60

agtaatagtc agcctcatct tccgc                                             85


<210>  34
<211>  88
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Vl_3_19_L3r_HV


<220>
<221>  misc_feature
<222>  (32)..(32)
<223>  60% original base and 40% randomization as M

<220>
<221>  misc_feature
<222>  (33)..(34)
<223>  60% original base and 40% randomization as N

<220>
<221>  misc_feature
<222>  (35)..(35)
<223>  60% original base and 40% randomization as M

<220>
<221>  misc_feature
<222>  (36)..(37)
<223>  60% original base and 40% randomization as N

<220>
<221>  misc_feature
<222>  (38)..(38)
<223>  60% original base and 40% randomization as M

<220>
<221>  misc_feature
<222>  (39)..(40)
<223>  60% original base and 40% randomization as N

<220>
<221>  misc_feature
<222>  (41)..(41)
<223>  60% original base and 40% randomization as M

<220>
<221>  misc_feature
<222>  (42)..(43)
<223>  60% original base and 40% randomization as N

<220>
<221>  misc_feature
<222>  (44)..(44)
<223>  60% original base and 40% randomization as M

<220>
<221>  misc_feature
<222>  (45)..(46)
<223>  60% original base and 40% randomization as N

<220>
<221>  misc_feature
<222>  (47)..(47)
<223>  60% original base and 40% randomization as M

<220>
<221>  misc_feature
<222>  (48)..(49)
<223>  60% original base and 40% randomization as N

<220>
<221>  misc_feature
<222>  (50)..(50)
<223>  60% original base and 40% randomization as M

<220>
<221>  misc_feature
<222>  (51)..(52)
<223>  60% original base and 40% randomization as N

<220>
<221>  misc_feature
<222>  (53)..(53)
<223>  60% original base and 40% randomization as M

<220>
<221>  misc_feature
<222>  (54)..(55)
<223>  60% original base and 40% randomization as N

<400>  34
ggacggtcag cttggtccct ccgccgaata ccmmatgatt accgctacta tcacgggagt       60

tacagtaata gtcagcctca tcttccgc                                          88


<210>  35
<211>  91
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Vl_3_19_L3r_HLV


<220>
<221>  misc_feature
<222>  (32)..(32)
<223>  60% original base and 40% randomization as M

<220>
<221>  misc_feature
<222>  (33)..(34)
<223>  60% original base and 40% randomization as N

<220>
<221>  misc_feature
<222>  (35)..(35)
<223>  60% original base and 40% randomization as M

<220>
<221>  misc_feature
<222>  (36)..(37)
<223>  60% original base and 40% randomization as N

<220>
<221>  misc_feature
<222>  (38)..(38)
<223>  60% original base and 40% randomization as M

<220>
<221>  misc_feature
<222>  (39)..(40)
<223>  60% original base and 40% randomization as N

<220>
<221>  misc_feature
<222>  (41)..(41)
<223>  60% original base and 40% randomization as M

<220>
<221>  misc_feature
<222>  (42)..(43)
<223>  60% original base and 40% randomization as N

<220>
<221>  misc_feature
<222>  (44)..(44)
<223>  60% original base and 40% randomization as M

<220>
<221>  misc_feature
<222>  (45)..(46)
<223>  60% original base and 40% randomization as N

<220>
<221>  misc_feature
<222>  (47)..(47)
<223>  60% original base and 40% randomization as M

<220>
<221>  misc_feature
<222>  (48)..(49)
<223>  60% original base and 40% randomization as N

<220>
<221>  misc_feature
<222>  (50)..(50)
<223>  60% original base and 40% randomization as M

<220>
<221>  misc_feature
<222>  (51)..(52)
<223>  60% original base and 40% randomization as N

<220>
<221>  misc_feature
<222>  (53)..(53)
<223>  60% original base and 40% randomization as M

<220>
<221>  misc_feature
<222>  (54)..(55)
<223>  60% original base and 40% randomization as N

<220>
<221>  misc_feature
<222>  (56)..(56)
<223>  60% original base and 40% randomization as M

<220>
<221>  misc_feature
<222>  (57)..(58)
<223>  60% original base and 40% randomization as N

<400>  35
ggacggtcag cttggtccct ccgccgaata crhmvwgatg attaccgcta ctatcacggg       60

agttacagta atagtcagcc tcatcttccg c                                      91


<210>  36
<211>  28
<212>  DNA
<213>  Artificial sequence

<220>
<223>  RJH80

<400>  36
ttcggcggag ggaccaagct gaccgtcc                                          28


<210>  37
<211>  25
<212>  DNA
<213>  Artificial sequence

<220>
<223>  DP47CDR3_ba (mod.)

<400>  37
cgcacagtaa tatacggccg tgtcc                                             25


<210>  38
<211>  70
<212>  DNA
<213>  Artificial sequence

<220>
<223>  DP47-v4-4


<220>
<221>  misc_feature
<222>  (29)..(29)
<223>  K=70%, R=30%)

<220>
<221>  misc_feature
<222>  (30)..(30)
<223>  G/D=20%, E/V/S=10%, A/P/R/L/T/Y=5%

<220>
<221>  misc_feature
<222>  (31)..(32)
<223>  G/Y/S=15%, A/D/T/R/P/L/V/N/W/F/I/E=4,6%

<220>
<221>  misc_feature
<222>  (33)..(33)
<223>  G/A/Y=20, P/W/S/D/T=8%

<220>
<221>  misc_feature
<222>  (34)..(34)
<223>  F=46%, L/M=15%, G/I/Y=8%

<400>  38
cgaggacacg gccgtatatt actgtgcgnn nnnngactac tggggccaag gaaccctggt       60

caccgtctcg                                                              70


<210>  39
<211>  72
<212>  DNA
<213>  Artificial sequence

<220>
<223>  DP47-v4-6


<220>
<221>  misc_feature
<222>  (29)..(29)
<223>  K=70%, R=30%

<220>
<221>  misc_feature
<222>  (30)..(30)
<223>  G/D=20%, E/V/S=10%, A/P/R/L/T/Y=5%

<220>
<221>  misc_feature
<222>  (31)..(34)
<223>  G/Y/S=15%, A/D/T/R/P/L/V/N/W/F/I/E=4,6%

<220>
<221>  misc_feature
<222>  (35)..(35)
<223>  G/A/Y=20, P/W/S/D/T=8%

<220>
<221>  misc_feature
<222>  (36)..(36)
<223>  F=46%, L/M=15%, G/I/Y=8%

<400>  39
cgaggacacg gccgtatatt actgtgcgnn nnnnnngact actggggcca aggaaccctg       60

gtcaccgtct cg                                                           72


<210>  40
<211>  74
<212>  DNA
<213>  Artificial sequence

<220>
<223>  DP47-v4-8


<220>
<221>  misc_feature
<222>  (29)..(29)
<223>  K=70%, R=30%

<220>
<221>  misc_feature
<222>  (30)..(30)
<223>  G/D=20%, E/V/S=10%, A/P/R/L/T/Y=5%

<220>
<221>  misc_feature
<222>  (31)..(36)
<223>  G/Y/S=15%, A/D/T/R/P/L/V/N/W/F/I/E=4,6%

<220>
<221>  misc_feature
<222>  (37)..(37)
<223>  G/A/Y=20, P/W/S/D/T=8%

<220>
<221>  misc_feature
<222>  (38)..(38)
<223>  F=46%, L/M=15%, G/I/Y=8%

<400>  40
cgaggacacg gccgtatatt actgtgcgnn nnnnnnnnga ctactggggc caaggaaccc       60

tggtcaccgt ctcg                                                         74


<210>  41
<211>  324
<212>  DNA
<213>  Artificial sequence

<220>
<223>  18D4 VL

<400>  41
gacatccaga tgacccagtc tccatccacc ctgtctgcat ctgtaggaga ccgtgtcacc       60

atcacttgcc gtgccagtca gagtattagt agctggttgg cctggtatca gcagaaacca      120

gggaaagccc ctaagctcct gatctatgat gcctccagtt tggaaagtgg ggtcccatca      180

cgtttcagcg gcagtggatc cgggacagaa ttcactctca ccatcagcag cttgcagcct      240

gatgattttg caacttatta ctgccaacag aataagaagt ttccttcggg gacgtttggc      300

cagggcacca aagtcgagat caag                                             324


<210>  42
<211>  354
<212>  DNA
<213>  Artificial sequence

<220>
<223>  18D4 VH

<400>  42
caggtgcaat tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cctccggagg cacattcagc agctacgcta taagctgggt gcgacaggcc      120

cctggacaag ggctcgagtg gatgggaggg atcatcccta tctttggtac agcaaactac      180

gcacagaagt tccagggcag ggtcaccatt actgcagaca aatccacgag cacagcctac      240

atggagctga gcagcctgag atctgaggac accgccgtgt attactgtgc gaaaggtaac      300

ttctacggtg gtctggacta ctggggccaa gggaccaccg tgaccgtctc ctca            354


<210>  43
<211>  321
<212>  DNA
<213>  Artificial sequence

<220>
<223>  11C7 VL

<400>  43
tcgtctgagc tgactcagga ccctgctgtg tctgtggcct tgggacagac agtcagggtc       60

acatgccaag gagacagcct cagaagttat tatgcaagct ggtaccagca gaagccagga      120

caggcccctg tacttgtcat ctatggtaaa aacaaccggc cctcagggat cccagaccga      180

ttctctggct ccagctcagg aaacacagct tccttgacca tcactggggc tcaggcggaa      240

gatgaggctg actattactg taactccatt aatagtactc gtaatgaggt attcggcgga      300

gggaccaagc tgaccgtcct a                                                321


<210>  44
<211>  354
<212>  DNA
<213>  Artificial sequence

<220>
<223>  11C7 VH

<400>  44
gaggtgcaat tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctccggatt cacctttagc agttatgcca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcagct attagcggta gtggtggtag cacatactac      180

gcagactccg tgaagggccg gttcaccatc tccaaagaca attccaagaa cacgctgtat      240

ctgcagatga acagcctgag agccgaggac acggccgtat attactgtgc gaaaacttct      300

ccgcgtgttc cgctggacta ctggggccaa ggaaccctgg tcaccgtctc gagt            354


<210>  45
<211>  108
<212>  PRT
<213>  Artificial sequence

<220>
<223>  18D4 VL

<400>  45

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Asn Lys Lys Phe Pro Ser 
                85                  90                  95      


Gly Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  46
<211>  118
<212>  PRT
<213>  Artificial sequence

<220>
<223>  18D4 VH

<400>  46

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Asn Phe Tyr Gly Gly Leu Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser 
        115             


<210>  47
<211>  107
<212>  PRT
<213>  Artificial sequence

<220>
<223>  11C7 VL

<400>  47

Ser Ser Glu Leu Thr Gln Asp Pro Ala Val Ser Val Ala Leu Gly Gln 
1               5                   10                  15      


Thr Val Arg Val Thr Cys Gln Gly Asp Ser Leu Arg Ser Tyr Tyr Ala 
            20                  25                  30          


Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Gly Lys Asn Asn Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser 
    50                  55                  60                  


Ser Ser Gly Asn Thr Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Asn Ser Ile Asn Ser Thr Arg Asn Glu 
                85                  90                  95      


Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105         


<210>  48
<211>  118
<212>  PRT
<213>  Artificial sequence

<220>
<223>  11C7 VH

<400>  48

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Lys Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Thr Ser Pro Arg Val Pro Leu Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  49
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  18D4 LCDR1

<400>  49
cgtgccagtc agagtattag tagctggttg gcc                                    33


<210>  50
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  18D4 LCDR2

<400>  50
gatgcctcca gtttggaaag t                                                 21


<210>  51
<211>  30
<212>  DNA
<213>  Artificial sequence

<220>
<223>  18D4 LCDR3

<400>  51
caacagaata agaagtttcc ttcggggacg                                        30


<210>  52
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  11C7 LCDR1

<400>  52
caaggagaca gcctcagaag ttattatgca agc                                    33


<210>  53
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  11C7 LCDR2

<400>  53
ggtaaaaaca accggccctc a                                                 21


<210>  54
<211>  30
<212>  DNA
<213>  Artificial sequence

<220>
<223>  11C7 LCDR3

<400>  54
aactccatta atagtactcg taatgaggta                                        30


<210>  55
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  18D4 LCDR1

<400>  55

Arg Ala Ser Gln Ser Ile Ser Ser Trp Leu Ala 
1               5                   10      


<210>  56
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  18D4 LCDR2

<400>  56

Asp Ala Ser Ser Leu Glu Ser 
1               5           


<210>  57
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  18D4 LCDR3

<400>  57

Gln Gln Asn Lys Lys Phe Pro Ser Gly Thr 
1               5                   10  


<210>  58
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  11C7 LCDR1

<400>  58

Gln Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser 
1               5                   10      


<210>  59
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  11C7 LCDR2

<400>  59

Gly Lys Asn Asn Arg Pro Ser 
1               5           


<210>  60
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  11C7 LCDR3

<400>  60

Asn Ser Ile Asn Ser Thr Arg Asn Glu Val 
1               5                   10  


<210>  61
<211>  15
<212>  DNA
<213>  Artificial sequence

<220>
<223>  18D4 HCDR1

<400>  61
agctacgcta taagc                                                        15


<210>  62
<211>  51
<212>  DNA
<213>  Artificial sequence

<220>
<223>  18D4 HCDR2

<400>  62
gggatcatcc ctatctttgg tacagcaaac tacgcacaga agttccaggg c                51


<210>  63
<211>  27
<212>  DNA
<213>  Artificial sequence

<220>
<223>  18D4 HCDR3

<400>  63
ggtaacttct acggtggtct ggactac                                           27


<210>  64
<211>  30
<212>  DNA
<213>  Artificial sequence

<220>
<223>  11C7 HCDR1

<400>  64
ggattcacct ttagcagtta tgccatgagc                                        30


<210>  65
<211>  51
<212>  DNA
<213>  Artificial sequence

<220>
<223>  11C7 HCDR2

<400>  65
gctattagcg gtagtggtgg tagcacatac tacgcagact ccgtgaaggg c                51


<210>  66
<211>  27
<212>  DNA
<213>  Artificial sequence

<220>
<223>  11C7 HCDR3

<400>  66
acttctccgc gtgttccgct ggactac                                           27


<210>  67
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  18D4 HCDR1

<400>  67

Ser Tyr Ala Ile Ser 
1               5   


<210>  68
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  18D4 HCDR2

<400>  68

Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  69
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  18D4 HCDR3

<400>  69

Gly Asn Phe Tyr Gly Gly Leu Asp Tyr 
1               5                   


<210>  70
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  11C7 HCDR1

<400>  70

Gly Phe Thr Phe Ser Ser Tyr Ala Met Ser 
1               5                   10  


<210>  71
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  11C7 HCDR2

<400>  71

Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  72
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  11C7 HCDR3

<400>  72

Thr Ser Pro Arg Val Pro Leu Asp Tyr 
1               5                   


<210>  73
<211>  645
<212>  DNA
<213>  Artificial sequence

<220>
<223>  18D4 Light chain

<400>  73
gacatccaga tgacccagtc tccatccacc ctgtctgcat ctgtaggaga ccgtgtcacc       60

atcacttgcc gtgccagtca gagtattagt agctggttgg cctggtatca gcagaaacca      120

gggaaagccc ctaagctcct gatctatgat gcctccagtt tggaaagtgg ggtcccatca      180

cgtttcagcg gcagtggatc cgggacagaa ttcactctca ccatcagcag cttgcagcct      240

gatgattttg caacttatta ctgccaacag aataagaagt ttccttcggg gacgtttggc      300

cagggcacca aagtcgagat caagcgtacg gtggctgcac catctgtctt catcttcccg      360

ccatctgatg agcagttgaa atctggaact gcctctgttg tgtgcctgct gaataacttc      420

tatcccagag aggccaaagt acagtggaag gtggataacg ccctccaatc gggtaactcc      480

caggagagtg tcacagagca ggacagcaag gacagcacct acagcctcag cagcaccctg      540

acgctgagca aagcagacta cgagaaacac aaagtctacg cctgcgaagt cacccatcag      600

ggcctgagct cgcccgtcac aaagagcttc aacaggggag agtgt                      645


<210>  74
<211>  1344
<212>  DNA
<213>  Artificial sequence

<220>
<223>  18D4 Heavy chain

<400>  74
caggtgcaat tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cctccggagg cacattcagc agctacgcta taagctgggt gcgacaggcc      120

cctggacaag ggctcgagtg gatgggaggg atcatcccta tctttggtac agcaaactac      180

gcacagaagt tccagggcag ggtcaccatt actgcagaca aatccacgag cacagcctac      240

atggagctga gcagcctgag atctgaggac accgccgtgt attactgtgc gaaaggtaac      300

ttctacggtg gtctggacta ctggggccaa gggaccaccg tgaccgtctc ctcagctagc      360

accaagggcc catcggtctt ccccctggca ccctcctcca agagcacctc tgggggcaca      420

gcggccctgg gctgcctggt caaggactac ttccccgaac cggtgacggt gtcgtggaac      480

tcaggcgccc tgaccagcgg cgtgcacacc ttcccggctg tcctacagtc ctcaggactc      540

tactccctca gcagcgtggt gaccgtgccc tccagcagct tgggcaccca gacctacatc      600

tgcaacgtga atcacaagcc cagcaacacc aaggtggaca agaaagttga gcccaaatct      660

tgtgacaaaa ctcacacatg cccaccgtgc ccagcacctg aactcctggg gggaccgtca      720

gtcttcctct tccccccaaa acccaaggac accctcatga tctcccggac ccctgaggtc      780

acatgcgtgg tggtggacgt gagccacgaa gaccctgagg tcaagttcaa ctggtacgtg      840

gacggcgtgg aggtgcataa tgccaagaca aagccgcggg aggagcagta caacagcacg      900

taccgtgtgg tcagcgtcct caccgtcctg caccaggact ggctgaatgg caaggagtac      960

aagtgcaagg tctccaacaa agccctccca gcccccatcg agaaaaccat ctccaaagcc     1020

aaagggcagc cccgagaacc acaggtgtac accctgcccc catcccggga tgagctgacc     1080

aagaaccagg tcagcctgac ctgcctggtc aaaggcttct atcccagcga catcgccgtg     1140

gagtgggaga gcaatgggca gccggagaac aactacaaga ccacgcctcc cgtgctggac     1200

tccgacggct ccttcttcct ctacagcaag ctcaccgtgg acaagagcag gtggcagcag     1260

gggaacgtct tctcatgctc cgtgatgcat gaggctctgc acaaccacta cacgcagaag     1320

agcctctccc tgtctccggg taaa                                            1344


<210>  75
<211>  639
<212>  DNA
<213>  Artificial sequence

<220>
<223>  11C7 Light chain

<400>  75
tcgtctgagc tgactcagga ccctgctgtg tctgtggcct tgggacagac agtcagggtc       60

acatgccaag gagacagcct cagaagttat tatgcaagct ggtaccagca gaagccagga      120

caggcccctg tacttgtcat ctatggtaaa aacaaccggc cctcagggat cccagaccga      180

ttctctggct ccagctcagg aaacacagct tccttgacca tcactggggc tcaggcggaa      240

gatgaggctg actattactg taactccatt aatagtactc gtaatgaggt attcggcgga      300

gggaccaagc tgaccgtcct aggtcaaccc aaggctgccc ccagcgtgac cctgttcccc      360

cccagcagcg aggaactgca ggccaacaag gccaccctgg tctgcctgat cagcgacttc      420

tacccaggcg ccgtgaccgt ggcctggaag gccgacagca gccccgtgaa ggccggcgtg      480

gagaccacca cccccagcaa gcagagcaac aacaagtacg ccgccagcag ctacctgagc      540

ctgacccccg agcagtggaa gagccacagg tcctacagct gccaggtgac ccacgagggc      600

agcaccgtgg agaaaaccgt ggcccccacc gagtgcagc                             639


<210>  76
<211>  1344
<212>  DNA
<213>  Artificial sequence

<220>
<223>  11C7 Heavy chain

<400>  76
gaggtgcaat tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctccggatt cacctttagc agttatgcca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcagct attagcggta gtggtggtag cacatactac      180

gcagactccg tgaagggccg gttcaccatc tccaaagaca attccaagaa cacgctgtat      240

ctgcagatga acagcctgag agccgaggac acggccgtat attactgtgc gaaaacttct      300

ccgcgtgttc cgctggacta ctggggccaa ggaaccctgg tcaccgtctc gagtgctagc      360

accaagggcc catcggtctt ccccctggca ccctcctcca agagcacctc tgggggcaca      420

gcggccctgg gctgcctggt caaggactac ttccccgaac cggtgacggt gtcgtggaac      480

tcaggcgccc tgaccagcgg cgtgcacacc ttcccggctg tcctacagtc ctcaggactc      540

tactccctca gcagcgtggt gaccgtgccc tccagcagct tgggcaccca gacctacatc      600

tgcaacgtga atcacaagcc cagcaacacc aaggtggaca agaaagttga gcccaaatct      660

tgtgacaaaa ctcacacatg cccaccgtgc ccagcacctg aactcctggg gggaccgtca      720

gtcttcctct tccccccaaa acccaaggac accctcatga tctcccggac ccctgaggtc      780

acatgcgtgg tggtggacgt gagccacgaa gaccctgagg tcaagttcaa ctggtacgtg      840

gacggcgtgg aggtgcataa tgccaagaca aagccgcggg aggagcagta caacagcacg      900

taccgtgtgg tcagcgtcct caccgtcctg caccaggact ggctgaatgg caaggagtac      960

aagtgcaagg tctccaacaa agccctccca gcccccatcg agaaaaccat ctccaaagcc     1020

aaagggcagc cccgagaacc acaggtgtac accctgcccc catcccggga tgagctgacc     1080

aagaaccagg tcagcctgac ctgcctggtc aaaggcttct atcccagcga catcgccgtg     1140

gagtgggaga gcaatgggca gccggagaac aactacaaga ccacgcctcc cgtgctggac     1200

tccgacggct ccttcttcct ctacagcaag ctcaccgtgg acaagagcag gtggcagcag     1260

gggaacgtct tctcatgctc cgtgatgcat gaggctctgc acaaccacta cacgcagaag     1320

agcctctccc tgtctccggg taaa                                            1344


<210>  77
<211>  215
<212>  PRT
<213>  Artificial sequence

<220>
<223>  18D4 Light chain

<400>  77

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Asn Lys Lys Phe Pro Ser 
                85                  90                  95      


Gly Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala 
            100                 105                 110         


Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
        115                 120                 125             


Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
    130                 135                 140                 


Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
145                 150                 155                 160 


Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
                165                 170                 175     


Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
            180                 185                 190         


Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
        195                 200                 205             


Ser Phe Asn Arg Gly Glu Cys 
    210                 215 


<210>  78
<211>  448
<212>  PRT
<213>  Artificial sequence

<220>
<223>  18D4 Heavy chain

<400>  78

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Asn Phe Tyr Gly Gly Leu Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr 
    210                 215                 220                 


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
225                 230                 235                 240 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                245                 250                 255     


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
            260                 265                 270         


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        275                 280                 285             


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
    290                 295                 300                 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
305                 310                 315                 320 


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
                325                 330                 335     


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            340                 345                 350         


Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys 
        355                 360                 365             


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    370                 375                 380                 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
385                 390                 395                 400 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
                405                 410                 415     


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            420                 425                 430         


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445             


<210>  79
<211>  213
<212>  PRT
<213>  Artificial sequence

<220>
<223>  11C7 Light chain

<400>  79

Ser Ser Glu Leu Thr Gln Asp Pro Ala Val Ser Val Ala Leu Gly Gln 
1               5                   10                  15      


Thr Val Arg Val Thr Cys Gln Gly Asp Ser Leu Arg Ser Tyr Tyr Ala 
            20                  25                  30          


Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Gly Lys Asn Asn Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser 
    50                  55                  60                  


Ser Ser Gly Asn Thr Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Asn Ser Ile Asn Ser Thr Arg Asn Glu 
                85                  90                  95      


Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro Lys Ala 
            100                 105                 110         


Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu Gln Ala 
        115                 120                 125             


Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro Gly Ala 
    130                 135                 140                 


Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala Gly Val 
145                 150                 155                 160 


Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala Ala Ser 
                165                 170                 175     


Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg Ser Tyr 
            180                 185                 190         


Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr Val Ala 
        195                 200                 205             


Pro Thr Glu Cys Ser 
    210             


<210>  80
<211>  448
<212>  PRT
<213>  Artificial sequence

<220>
<223>  11C7 Heavy chain

<400>  80

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Lys Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Thr Ser Pro Arg Val Pro Leu Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr 
    210                 215                 220                 


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
225                 230                 235                 240 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                245                 250                 255     


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
            260                 265                 270         


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        275                 280                 285             


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
    290                 295                 300                 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
305                 310                 315                 320 


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
                325                 330                 335     


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            340                 345                 350         


Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys 
        355                 360                 365             


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    370                 375                 380                 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
385                 390                 395                 400 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
                405                 410                 415     


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            420                 425                 430         


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445             


<210>  81
<211>  1344
<212>  DNA
<213>  Artificial sequence

<220>
<223>  18D4 Heavy chain PGLALA

<400>  81
caggtgcaat tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cctccggagg cacattcagc agctacgcta taagctgggt gcgacaggcc      120

cctggacaag ggctcgagtg gatgggaggg atcatcccta tctttggtac agcaaactac      180

gcacagaagt tccagggcag ggtcaccatt actgcagaca aatccacgag cacagcctac      240

atggagctga gcagcctgag atctgaggac accgccgtgt attactgtgc gaaaggtaac      300

ttctacggtg gtctggacta ctggggccaa gggaccaccg tgaccgtctc ctcagctagc      360

accaagggcc catcggtctt ccccctggca ccctcctcca agagcacctc tgggggcaca      420

gcggccctgg gctgcctggt caaggactac ttccccgaac cggtgacggt gtcgtggaac      480

tcaggcgccc tgaccagcgg cgtgcacacc ttcccggctg tcctacagtc ctcaggactc      540

tactccctca gcagcgtggt gaccgtgccc tccagcagct tgggcaccca gacctacatc      600

tgcaacgtga atcacaagcc cagcaacacc aaggtggaca agaaagttga gcccaaatct      660

tgtgacaaaa ctcacacatg cccaccgtgc ccagcacctg aagctgcagg gggaccgtca      720

gtcttcctct tccccccaaa acccaaggac accctcatga tctcccggac ccctgaggtc      780

acatgcgtgg tggtggacgt gagccacgaa gaccctgagg tcaagttcaa ctggtacgtg      840

gacggcgtgg aggtgcataa tgccaagaca aagccgcggg aggagcagta caacagcacg      900

taccgtgtgg tcagcgtcct caccgtcctg caccaggact ggctgaatgg caaggagtac      960

aagtgcaagg tctccaacaa agccctcggc gcccccatcg agaaaaccat ctccaaagcc     1020

aaagggcagc cccgagaacc acaggtgtac accctgcccc catcccggga tgagctgacc     1080

aagaaccagg tcagcctgac ctgcctggtc aaaggcttct atcccagcga catcgccgtg     1140

gagtgggaga gcaatgggca gccggagaac aactacaaga ccacgcctcc cgtgctggac     1200

tccgacggct ccttcttcct ctacagcaag ctcaccgtgg acaagagcag gtggcagcag     1260

gggaacgtct tctcatgctc cgtgatgcat gaggctctgc acaaccacta cacgcagaag     1320

agcctctccc tgtctccggg taaa                                            1344


<210>  82
<211>  1344
<212>  DNA
<213>  Artificial sequence

<220>
<223>  11C7 Heavy chain PGLALA

<400>  82
gaggtgcaat tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctccggatt cacctttagc agttatgcca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcagct attagcggta gtggtggtag cacatactac      180

gcagactccg tgaagggccg gttcaccatc tccaaagaca attccaagaa cacgctgtat      240

ctgcagatga acagcctgag agccgaggac acggccgtat attactgtgc gaaaacttct      300

ccgcgtgttc cgctggacta ctggggccaa ggaaccctgg tcaccgtctc gagtgctagc      360

accaagggcc catcggtctt ccccctggca ccctcctcca agagcacctc tgggggcaca      420

gcggccctgg gctgcctggt caaggactac ttccccgaac cggtgacggt gtcgtggaac      480

tcaggcgccc tgaccagcgg cgtgcacacc ttcccggctg tcctacagtc ctcaggactc      540

tactccctca gcagcgtggt gaccgtgccc tccagcagct tgggcaccca gacctacatc      600

tgcaacgtga atcacaagcc cagcaacacc aaggtggaca agaaagttga gcccaaatct      660

tgtgacaaaa ctcacacatg cccaccgtgc ccagcacctg aagctgcagg gggaccgtca      720

gtcttcctct tccccccaaa acccaaggac accctcatga tctcccggac ccctgaggtc      780

acatgcgtgg tggtggacgt gagccacgaa gaccctgagg tcaagttcaa ctggtacgtg      840

gacggcgtgg aggtgcataa tgccaagaca aagccgcggg aggagcagta caacagcacg      900

taccgtgtgg tcagcgtcct caccgtcctg caccaggact ggctgaatgg caaggagtac      960

aagtgcaagg tctccaacaa agccctcggc gcccccatcg agaaaaccat ctccaaagcc     1020

aaagggcagc cccgagaacc acaggtgtac accctgcccc catcccggga tgagctgacc     1080

aagaaccagg tcagcctgac ctgcctggtc aaaggcttct atcccagcga catcgccgtg     1140

gagtgggaga gcaatgggca gccggagaac aactacaaga ccacgcctcc cgtgctggac     1200

tccgacggct ccttcttcct ctacagcaag ctcaccgtgg acaagagcag gtggcagcag     1260

gggaacgtct tctcatgctc cgtgatgcat gaggctctgc acaaccacta cacgcagaag     1320

agcctctccc tgtctccggg taaa                                            1344


<210>  83
<211>  448
<212>  PRT
<213>  Artificial sequence

<220>
<223>  18D4 Heavy chain PGLALA

<400>  83

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Asn Phe Tyr Gly Gly Leu Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr 
    210                 215                 220                 


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser 
225                 230                 235                 240 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                245                 250                 255     


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
            260                 265                 270         


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        275                 280                 285             


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
    290                 295                 300                 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
305                 310                 315                 320 


Lys Cys Lys Val Ser Asn Lys Ala Leu Gly Ala Pro Ile Glu Lys Thr 
                325                 330                 335     


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            340                 345                 350         


Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys 
        355                 360                 365             


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    370                 375                 380                 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
385                 390                 395                 400 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
                405                 410                 415     


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            420                 425                 430         


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445             


<210>  84
<211>  448
<212>  PRT
<213>  Artificial sequence

<220>
<223>  11C7 Heavy chain PGLALA

<400>  84

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Lys Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Thr Ser Pro Arg Val Pro Leu Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr 
    210                 215                 220                 


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser 
225                 230                 235                 240 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                245                 250                 255     


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
            260                 265                 270         


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        275                 280                 285             


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
    290                 295                 300                 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
305                 310                 315                 320 


Lys Cys Lys Val Ser Asn Lys Ala Leu Gly Ala Pro Ile Glu Lys Thr 
                325                 330                 335     


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            340                 345                 350         


Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys 
        355                 360                 365             


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    370                 375                 380                 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
385                 390                 395                 400 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
                405                 410                 415     


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            420                 425                 430         


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445             


<210>  85
<211>  163
<212>  PRT
<213>  Homo sapiens

<400>  85

Leu Gln Asp Pro Cys Ser Asn Cys Pro Ala Gly Thr Phe Cys Asp Asn 
1               5                   10                  15      


Asn Arg Asn Gln Ile Cys Ser Pro Cys Pro Pro Asn Ser Phe Ser Ser 
            20                  25                  30          


Ala Gly Gly Gln Arg Thr Cys Asp Ile Cys Arg Gln Cys Lys Gly Val 
        35                  40                  45              


Phe Arg Thr Arg Lys Glu Cys Ser Ser Thr Ser Asn Ala Glu Cys Asp 
    50                  55                  60                  


Cys Thr Pro Gly Phe His Cys Leu Gly Ala Gly Cys Ser Met Cys Glu 
65                  70                  75                  80  


Gln Asp Cys Lys Gln Gly Gln Glu Leu Thr Lys Lys Gly Cys Lys Asp 
                85                  90                  95      


Cys Cys Phe Gly Thr Phe Asn Asp Gln Lys Arg Gly Ile Cys Arg Pro 
            100                 105                 110         


Trp Thr Asn Cys Ser Leu Asp Gly Lys Ser Val Leu Val Asn Gly Thr 
        115                 120                 125             


Lys Glu Arg Asp Val Val Cys Gly Pro Ser Pro Ala Asp Leu Ser Pro 
    130                 135                 140                 


Gly Ala Ser Ser Val Thr Pro Pro Ala Pro Ala Arg Glu Pro Gly His 
145                 150                 155                 160 


Ser Pro Gln 
            


<210>  86
<211>  163
<212>  PRT
<213>  Cynomolgus

<400>  86

Leu Gln Asp Leu Cys Ser Asn Cys Pro Ala Gly Thr Phe Cys Asp Asn 
1               5                   10                  15      


Asn Arg Ser Gln Ile Cys Ser Pro Cys Pro Pro Asn Ser Phe Ser Ser 
            20                  25                  30          


Ala Gly Gly Gln Arg Thr Cys Asp Ile Cys Arg Gln Cys Lys Gly Val 
        35                  40                  45              


Phe Lys Thr Arg Lys Glu Cys Ser Ser Thr Ser Asn Ala Glu Cys Asp 
    50                  55                  60                  


Cys Ile Ser Gly Tyr His Cys Leu Gly Ala Glu Cys Ser Met Cys Glu 
65                  70                  75                  80  


Gln Asp Cys Lys Gln Gly Gln Glu Leu Thr Lys Lys Gly Cys Lys Asp 
                85                  90                  95      


Cys Cys Phe Gly Thr Phe Asn Asp Gln Lys Arg Gly Ile Cys Arg Pro 
            100                 105                 110         


Trp Thr Asn Cys Ser Leu Asp Gly Lys Ser Val Leu Val Asn Gly Thr 
        115                 120                 125             


Lys Glu Arg Asp Val Val Cys Gly Pro Ser Pro Ala Asp Leu Ser Pro 
    130                 135                 140                 


Gly Ala Ser Ser Ala Thr Pro Pro Ala Pro Ala Arg Glu Pro Gly His 
145                 150                 155                 160 


Ser Pro Gln 
            


<210>  87
<211>  164
<212>  PRT
<213>  Mus musculus

<400>  87

Val Gln Asn Ser Cys Asp Asn Cys Gln Pro Gly Thr Phe Cys Arg Lys 
1               5                   10                  15      


Tyr Asn Pro Val Cys Lys Ser Cys Pro Pro Ser Thr Phe Ser Ser Ile 
            20                  25                  30          


Gly Gly Gln Pro Asn Cys Asn Ile Cys Arg Val Cys Ala Gly Tyr Phe 
        35                  40                  45              


Arg Phe Lys Lys Phe Cys Ser Ser Thr His Asn Ala Glu Cys Glu Cys 
    50                  55                  60                  


Ile Glu Gly Phe His Cys Leu Gly Pro Gln Cys Thr Arg Cys Glu Lys 
65                  70                  75                  80  


Asp Cys Arg Pro Gly Gln Glu Leu Thr Lys Gln Gly Cys Lys Thr Cys 
                85                  90                  95      


Ser Leu Gly Thr Phe Asn Asp Gln Asn Gly Thr Gly Val Cys Arg Pro 
            100                 105                 110         


Trp Thr Asn Cys Ser Leu Asp Gly Arg Ser Val Leu Lys Thr Gly Thr 
        115                 120                 125             


Thr Glu Lys Asp Val Val Cys Gly Pro Pro Val Val Ser Phe Ser Pro 
    130                 135                 140                 


Ser Thr Thr Ile Ser Val Thr Pro Glu Gly Gly Pro Gly Gly His Ser 
145                 150                 155                 160 


Leu Gln Val Leu 
                


<210>  88
<211>  681
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Fc hole chain

<400>  88
gacaaaactc acacatgccc accgtgccca gcacctgaac tcctgggggg accgtcagtc       60

ttcctcttcc ccccaaaacc caaggacacc ctcatgatct cccggacccc tgaggtcaca      120

tgcgtggtgg tggacgtgag ccacgaagac cctgaggtca agttcaactg gtacgtggac      180

ggcgtggagg tgcataatgc caagacaaag ccgcgggagg agcagtacaa cagcacgtac      240

cgtgtggtca gcgtcctcac cgtcctgcac caggactggc tgaatggcaa ggagtacaag      300

tgcaaggtct ccaacaaagc cctcccagcc cccatcgaga aaaccatctc caaagccaaa      360

gggcagcccc gagaaccaca ggtgtgcacc ctgcccccat cccgggatga gctgaccaag      420

aaccaggtca gcctctcgtg cgcagtcaaa ggcttctatc ccagcgacat cgccgtggag      480

tgggagagca atgggcagcc ggagaacaac tacaagacca cgcctcccgt gctggactcc      540

gacggctcct tcttcctcgt gagcaagctc accgtggaca agagcaggtg gcagcagggg      600

aacgtcttct catgctccgt gatgcatgag gctctgcaca accactacac gcagaagagc      660

ctctccctgt ctccgggtaa a                                                681


<210>  89
<211>  1266
<212>  DNA
<213>  Artificial sequence

<220>
<223>  human 4-1BB antigen Fc knob chain

<400>  89
ctgcaggacc cctgcagcaa ctgccctgcc ggcaccttct gcgacaacaa ccggaaccag       60

atctgcagcc cctgcccccc caacagcttc agctctgccg gcggacagcg gacctgcgac      120

atctgcagac agtgcaaggg cgtgttcaga acccggaaag agtgcagcag caccagcaac      180

gccgagtgcg actgcacccc cggcttccat tgtctgggag ccggctgcag catgtgcgag      240

caggactgca agcagggcca ggaactgacc aagaagggct gcaaggactg ctgcttcggc      300

accttcaacg accagaagcg gggcatctgc cggccctgga ccaactgtag cctggacggc      360

aagagcgtgc tggtcaacgg caccaaagaa cgggacgtcg tgtgcggccc cagccctgct      420

gatctgtctc ctggggccag cagcgtgacc cctcctgccc ctgccagaga gcctggccac      480

tctcctcagg tcgacgaaca gttatatttt cagggcggct cacccaaatc tgcagacaaa      540

actcacacat gcccaccgtg cccagcacct gaactcctgg ggggaccgtc agtcttcctc      600

ttccccccaa aacccaagga caccctcatg atctcccgga cccctgaggt cacatgcgtg      660

gtggtggacg tgagccacga agaccctgag gtcaagttca actggtacgt ggacggcgtg      720

gaggtgcata atgccaagac aaagccgcgg gaggagcagt acaacagcac gtaccgtgtg      780

gtcagcgtcc tcaccgtcct gcaccaggac tggctgaatg gcaaggagta caagtgcaag      840

gtctccaaca aagccctccc agcccccatc gagaaaacca tctccaaagc caaagggcag      900

ccccgagaac cacaggtgta caccctgccc ccatgccggg atgagctgac caagaaccag      960

gtcagcctgt ggtgcctggt caaaggcttc tatcccagcg acatcgccgt ggagtgggag     1020

agcaatgggc agccggagaa caactacaag accacgcctc ccgtgctgga ctccgacggc     1080

tccttcttcc tctacagcaa gctcaccgtg gacaagagca ggtggcagca ggggaacgtc     1140

ttctcatgct ccgtgatgca tgaggctctg cacaaccact acacgcagaa gagcctctcc     1200

ctgtctccgg gtaaatccgg aggcctgaac gacatcttcg aggcccagaa gattgaatgg     1260

cacgag                                                                1266


<210>  90
<211>  1266
<212>  DNA
<213>  Artificial sequence

<220>
<223>  cynomolgus 4-1BB antigen

Fc knob chain

<400>  90
ttgcaggatc tgtgtagtaa ctgcccagct ggtacattct gtgataataa caggagtcag       60

atttgcagtc cctgtcctcc aaatagtttc tccagcgcag gtggacaaag gacctgtgac      120

atatgcaggc agtgtaaagg tgttttcaag accaggaagg agtgttcctc caccagcaat      180

gcagagtgtg actgcatttc agggtatcac tgcctggggg cagagtgcag catgtgtgaa      240

caggattgta aacaaggtca agaattgaca aaaaaaggtt gtaaagactg ttgctttggg      300

acatttaatg accagaaacg tggcatctgt cgcccctgga caaactgttc tttggatgga      360

aagtctgtgc ttgtgaatgg gacgaaggag agggacgtgg tctgcggacc atctccagcc      420

gacctctctc caggagcatc ctctgcgacc ccgcctgccc ctgcgagaga gccaggacac      480

tctccgcagg tcgacgaaca gttatatttt cagggcggct cacccaaatc tgcagacaaa      540

actcacacat gcccaccgtg cccagcacct gaactcctgg ggggaccgtc agtcttcctc      600

ttccccccaa aacccaagga caccctcatg atctcccgga cccctgaggt cacatgcgtg      660

gtggtggacg tgagccacga agaccctgag gtcaagttca actggtacgt ggacggcgtg      720

gaggtgcata atgccaagac aaagccgcgg gaggagcagt acaacagcac gtaccgtgtg      780

gtcagcgtcc tcaccgtcct gcaccaggac tggctgaatg gcaaggagta caagtgcaag      840

gtctccaaca aagccctccc agcccccatc gagaaaacca tctccaaagc caaagggcag      900

ccccgagaac cacaggtgta caccctgccc ccatgccggg atgagctgac caagaaccag      960

gtcagcctgt ggtgcctggt caaaggcttc tatcccagcg acatcgccgt ggagtgggag     1020

agcaatgggc agccggagaa caactacaag accacgcctc ccgtgctgga ctccgacggc     1080

tccttcttcc tctacagcaa gctcaccgtg gacaagagca ggtggcagca ggggaacgtc     1140

ttctcatgct ccgtgatgca tgaggctctg cacaaccact acacgcagaa gagcctctcc     1200

ctgtctccgg gtaaatccgg aggcctgaac gacatcttcg aggcccagaa gattgaatgg     1260

cacgag                                                                1266


<210>  91
<211>  1269
<212>  DNA
<213>  Artificial sequence

<220>
<223>  murine 4-1BB antigen Fc knob chain

<400>  91
gtgcagaaca gctgcgacaa ctgccagccc ggcaccttct gccggaagta caaccccgtg       60

tgcaagagct gcccccccag caccttcagc agcatcggcg gccagcccaa ctgcaacatc      120

tgcagagtgt gcgccggcta cttccggttc aagaagttct gcagcagcac ccacaacgcc      180

gagtgcgagt gcatcgaggg cttccactgc ctgggccccc agtgcaccag atgcgagaag      240

gactgcagac ccggccagga actgaccaag cagggctgta agacctgcag cctgggcacc      300

ttcaacgacc agaacgggac cggcgtgtgc cggccttgga ccaattgcag cctggacggg      360

agaagcgtgc tgaaaaccgg caccaccgag aaggacgtcg tgtgcggccc tcccgtggtg      420

tccttcagcc ctagcaccac catcagcgtg acccctgaag gcggccctgg cggacactct      480

ctgcaggtcc tggtcgacga acagttatat tttcagggcg gctcacccaa atctgcagac      540

aaaactcaca catgcccacc gtgcccagca cctgaactcc tggggggacc gtcagtcttc      600

ctcttccccc caaaacccaa ggacaccctc atgatctccc ggacccctga ggtcacatgc      660

gtggtggtgg acgtgagcca cgaagaccct gaggtcaagt tcaactggta cgtggacggc      720

gtggaggtgc ataatgccaa gacaaagccg cgggaggagc agtacaacag cacgtaccgt      780

gtggtcagcg tcctcaccgt cctgcaccag gactggctga atggcaagga gtacaagtgc      840

aaggtctcca acaaagccct cccagccccc atcgagaaaa ccatctccaa agccaaaggg      900

cagccccgag aaccacaggt gtacaccctg cccccatgcc gggatgagct gaccaagaac      960

caggtcagcc tgtggtgcct ggtcaaaggc ttctatccca gcgacatcgc cgtggagtgg     1020

gagagcaatg ggcagccgga gaacaactac aagaccacgc ctcccgtgct ggactccgac     1080

ggctccttct tcctctacag caagctcacc gtggacaaga gcaggtggca gcaggggaac     1140

gtcttctcat gctccgtgat gcatgaggct ctgcacaacc actacacgca gaagagcctc     1200

tccctgtctc cgggtaaatc cggaggcctg aacgacatct tcgaggccca gaagattgaa     1260

tggcacgag                                                             1269


<210>  92
<211>  227
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Fc hole chain

<400>  92

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Cys Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Val Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys 
225         


<210>  93
<211>  422
<212>  PRT
<213>  Artificial sequence

<220>
<223>  human 4-1BB antigen Fc knob chain

<400>  93

Leu Gln Asp Pro Cys Ser Asn Cys Pro Ala Gly Thr Phe Cys Asp Asn 
1               5                   10                  15      


Asn Arg Asn Gln Ile Cys Ser Pro Cys Pro Pro Asn Ser Phe Ser Ser 
            20                  25                  30          


Ala Gly Gly Gln Arg Thr Cys Asp Ile Cys Arg Gln Cys Lys Gly Val 
        35                  40                  45              


Phe Arg Thr Arg Lys Glu Cys Ser Ser Thr Ser Asn Ala Glu Cys Asp 
    50                  55                  60                  


Cys Thr Pro Gly Phe His Cys Leu Gly Ala Gly Cys Ser Met Cys Glu 
65                  70                  75                  80  


Gln Asp Cys Lys Gln Gly Gln Glu Leu Thr Lys Lys Gly Cys Lys Asp 
                85                  90                  95      


Cys Cys Phe Gly Thr Phe Asn Asp Gln Lys Arg Gly Ile Cys Arg Pro 
            100                 105                 110         


Trp Thr Asn Cys Ser Leu Asp Gly Lys Ser Val Leu Val Asn Gly Thr 
        115                 120                 125             


Lys Glu Arg Asp Val Val Cys Gly Pro Ser Pro Ala Asp Leu Ser Pro 
    130                 135                 140                 


Gly Ala Ser Ser Val Thr Pro Pro Ala Pro Ala Arg Glu Pro Gly His 
145                 150                 155                 160 


Ser Pro Gln Val Asp Glu Gln Leu Tyr Phe Gln Gly Gly Ser Pro Lys 
                165                 170                 175     


Ser Ala Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
            180                 185                 190         


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
        195                 200                 205             


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
    210                 215                 220                 


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
225                 230                 235                 240 


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
                245                 250                 255     


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
            260                 265                 270         


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
        275                 280                 285             


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
    290                 295                 300                 


Gln Val Tyr Thr Leu Pro Pro Cys Arg Asp Glu Leu Thr Lys Asn Gln 
305                 310                 315                 320 


Val Ser Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
                325                 330                 335     


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
            340                 345                 350         


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
        355                 360                 365             


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
    370                 375                 380                 


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
385                 390                 395                 400 


Leu Ser Pro Gly Lys Ser Gly Gly Leu Asn Asp Ile Phe Glu Ala Gln 
                405                 410                 415     


Lys Ile Glu Trp His Glu 
            420         


<210>  94
<211>  422
<212>  PRT
<213>  Artificial sequence

<220>
<223>  cynomolgus 4-1BB antigen Fc knob chain

<400>  94

Leu Gln Asp Leu Cys Ser Asn Cys Pro Ala Gly Thr Phe Cys Asp Asn 
1               5                   10                  15      


Asn Arg Ser Gln Ile Cys Ser Pro Cys Pro Pro Asn Ser Phe Ser Ser 
            20                  25                  30          


Ala Gly Gly Gln Arg Thr Cys Asp Ile Cys Arg Gln Cys Lys Gly Val 
        35                  40                  45              


Phe Lys Thr Arg Lys Glu Cys Ser Ser Thr Ser Asn Ala Glu Cys Asp 
    50                  55                  60                  


Cys Ile Ser Gly Tyr His Cys Leu Gly Ala Glu Cys Ser Met Cys Glu 
65                  70                  75                  80  


Gln Asp Cys Lys Gln Gly Gln Glu Leu Thr Lys Lys Gly Cys Lys Asp 
                85                  90                  95      


Cys Cys Phe Gly Thr Phe Asn Asp Gln Lys Arg Gly Ile Cys Arg Pro 
            100                 105                 110         


Trp Thr Asn Cys Ser Leu Asp Gly Lys Ser Val Leu Val Asn Gly Thr 
        115                 120                 125             


Lys Glu Arg Asp Val Val Cys Gly Pro Ser Pro Ala Asp Leu Ser Pro 
    130                 135                 140                 


Gly Ala Ser Ser Ala Thr Pro Pro Ala Pro Ala Arg Glu Pro Gly His 
145                 150                 155                 160 


Ser Pro Gln Val Asp Glu Gln Leu Tyr Phe Gln Gly Gly Ser Pro Lys 
                165                 170                 175     


Ser Ala Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
            180                 185                 190         


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
        195                 200                 205             


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
    210                 215                 220                 


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
225                 230                 235                 240 


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
                245                 250                 255     


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
            260                 265                 270         


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
        275                 280                 285             


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
    290                 295                 300                 


Gln Val Tyr Thr Leu Pro Pro Cys Arg Asp Glu Leu Thr Lys Asn Gln 
305                 310                 315                 320 


Val Ser Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
                325                 330                 335     


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
            340                 345                 350         


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
        355                 360                 365             


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
    370                 375                 380                 


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
385                 390                 395                 400 


Leu Ser Pro Gly Lys Ser Gly Gly Leu Asn Asp Ile Phe Glu Ala Gln 
                405                 410                 415     


Lys Ile Glu Trp His Glu 
            420         


<210>  95
<211>  423
<212>  PRT
<213>  Artificial sequence

<220>
<223>  murine 4-1BB antigen Fc knob chain

<400>  95

Val Gln Asn Ser Cys Asp Asn Cys Gln Pro Gly Thr Phe Cys Arg Lys 
1               5                   10                  15      


Tyr Asn Pro Val Cys Lys Ser Cys Pro Pro Ser Thr Phe Ser Ser Ile 
            20                  25                  30          


Gly Gly Gln Pro Asn Cys Asn Ile Cys Arg Val Cys Ala Gly Tyr Phe 
        35                  40                  45              


Arg Phe Lys Lys Phe Cys Ser Ser Thr His Asn Ala Glu Cys Glu Cys 
    50                  55                  60                  


Ile Glu Gly Phe His Cys Leu Gly Pro Gln Cys Thr Arg Cys Glu Lys 
65                  70                  75                  80  


Asp Cys Arg Pro Gly Gln Glu Leu Thr Lys Gln Gly Cys Lys Thr Cys 
                85                  90                  95      


Ser Leu Gly Thr Phe Asn Asp Gln Asn Gly Thr Gly Val Cys Arg Pro 
            100                 105                 110         


Trp Thr Asn Cys Ser Leu Asp Gly Arg Ser Val Leu Lys Thr Gly Thr 
        115                 120                 125             


Thr Glu Lys Asp Val Val Cys Gly Pro Pro Val Val Ser Phe Ser Pro 
    130                 135                 140                 


Ser Thr Thr Ile Ser Val Thr Pro Glu Gly Gly Pro Gly Gly His Ser 
145                 150                 155                 160 


Leu Gln Val Leu Val Asp Glu Gln Leu Tyr Phe Gln Gly Gly Ser Pro 
                165                 170                 175     


Lys Ser Ala Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
            180                 185                 190         


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
        195                 200                 205             


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
    210                 215                 220                 


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
225                 230                 235                 240 


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
                245                 250                 255     


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
            260                 265                 270         


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
        275                 280                 285             


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
    290                 295                 300                 


Pro Gln Val Tyr Thr Leu Pro Pro Cys Arg Asp Glu Leu Thr Lys Asn 
305                 310                 315                 320 


Gln Val Ser Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
                325                 330                 335     


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
            340                 345                 350         


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
        355                 360                 365             


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
    370                 375                 380                 


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
385                 390                 395                 400 


Ser Leu Ser Pro Gly Lys Ser Gly Gly Leu Asn Asp Ile Phe Glu Ala 
                405                 410                 415     


Gln Lys Ile Glu Trp His Glu 
            420             


<210>  96
<211>  594
<212>  DNA
<213>  Artificial sequence

<220>
<223>  human 4-1BB His

<400>  96
ctgcaggacc cctgcagcaa ctgccctgcc ggcaccttct gcgacaacaa ccggaaccag       60

atctgcagcc cctgcccccc caacagcttc agctctgccg gcggacagcg gacctgcgac      120

atctgcagac agtgcaaggg cgtgttcaga acccggaaag agtgcagcag caccagcaac      180

gccgagtgcg actgcacccc cggcttccat tgtctgggag ccggctgcag catgtgcgag      240

caggactgca agcagggcca ggaactgacc aagaagggct gcaaggactg ctgcttcggc      300

accttcaacg accagaagcg gggcatctgc cggccctgga ccaactgtag cctggacggc      360

aagagcgtgc tggtcaacgg caccaaagaa cgggacgtcg tgtgcggccc cagccctgct      420

gatctgtctc ctggggccag cagcgtgacc cctcctgccc ctgccagaga gcctggccac      480

tctcctcagg tcgacgaaca gttatatttt cagggcggct caggcctgaa cgacatcttc      540

gaggcccaga agatcgagtg gcacgaggct cgagctcacc accatcacca tcac            594


<210>  97
<211>  198
<212>  PRT
<213>  Artificial sequence

<220>
<223>  human 4-1BB His

<400>  97

Leu Gln Asp Pro Cys Ser Asn Cys Pro Ala Gly Thr Phe Cys Asp Asn 
1               5                   10                  15      


Asn Arg Asn Gln Ile Cys Ser Pro Cys Pro Pro Asn Ser Phe Ser Ser 
            20                  25                  30          


Ala Gly Gly Gln Arg Thr Cys Asp Ile Cys Arg Gln Cys Lys Gly Val 
        35                  40                  45              


Phe Arg Thr Arg Lys Glu Cys Ser Ser Thr Ser Asn Ala Glu Cys Asp 
    50                  55                  60                  


Cys Thr Pro Gly Phe His Cys Leu Gly Ala Gly Cys Ser Met Cys Glu 
65                  70                  75                  80  


Gln Asp Cys Lys Gln Gly Gln Glu Leu Thr Lys Lys Gly Cys Lys Asp 
                85                  90                  95      


Cys Cys Phe Gly Thr Phe Asn Asp Gln Lys Arg Gly Ile Cys Arg Pro 
            100                 105                 110         


Trp Thr Asn Cys Ser Leu Asp Gly Lys Ser Val Leu Val Asn Gly Thr 
        115                 120                 125             


Lys Glu Arg Asp Val Val Cys Gly Pro Ser Pro Ala Asp Leu Ser Pro 
    130                 135                 140                 


Gly Ala Ser Ser Val Thr Pro Pro Ala Pro Ala Arg Glu Pro Gly His 
145                 150                 155                 160 


Ser Pro Gln Val Asp Glu Gln Leu Tyr Phe Gln Gly Gly Ser Gly Leu 
                165                 170                 175     


Asn Asp Ile Phe Glu Ala Gln Lys Ile Glu Trp His Glu Ala Arg Ala 
            180                 185                 190         


His His His His His His 
        195             


<210>  98
<211>  2166
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Dimeric ligand (71-254)- CL* Fc knob chain

<400>  98
agagagggcc ctgagctgag ccccgatgat cctgctggac tgctggacct gcggcagggc       60

atgtttgctc agctggtggc ccagaacgtg ctgctgatcg atggccccct gtcctggtac      120

agcgatcctg gactggctgg cgtgtcactg acaggcggcc tgagctacaa agaggacacc      180

aaagaactgg tggtggccaa ggccggcgtg tactacgtgt tctttcagct ggaactgcgg      240

agagtggtgg ccggcgaagg atctggctct gtgtctctgg ccctgcatct gcagcctctg      300

agaagcgctg ctggcgctgc agctctggca ctgacagtgg atctgcctcc tgccagctcc      360

gaggcccgga atagcgcatt tgggtttcaa ggcaggctgc tgcacctgtc tgccggccag      420

aggctgggag tgcatctgca cacagaggcc agggctagac acgcctggca gctgacacag      480

ggcgctacag tgctgggcct gttcagagtg acccccgaga ttccagccgg cctgccttct      540

ccaagaagcg aaggcggagg cggatctggc ggcggaggat ctagagaggg acccgaactg      600

tcccctgacg atccagccgg gctgctggat ctgagacagg gaatgttcgc ccagctggtg      660

gctcagaatg tgctgctgat tgacggacct ctgagctggt actccgaccc agggctggca      720

ggggtgtccc tgactggggg actgtcctac aaagaagata caaaagaact ggtggtggct      780

aaagctgggg tgtactatgt gttttttcag ctggaactga ggcgggtggt ggctggggag      840

ggctcaggat ctgtgtccct ggctctgcat ctgcagccac tgcgctctgc tgctggcgca      900

gctgcactgg ctctgactgt ggacctgcca ccagcctcta gcgaggccag aaacagcgcc      960

ttcgggttcc aaggacgcct gctgcatctg agcgccggac agcgcctggg agtgcatctg     1020

catactgaag ccagagcccg gcatgcttgg cagctgactc agggggcaac tgtgctggga     1080

ctgtttcgcg tgacacctga gatccctgcc ggactgccaa gccctagatc agaagggggc     1140

ggaggttccg gagggggagg atctcgtacg gtggctgcac catctgtctt tatcttccca     1200

cccagcgacc ggaagctgaa gtctggcaca gccagcgtcg tgtgcctgct gaataacttc     1260

tacccccgcg aggccaaggt gcagtggaag gtggacaatg ccctgcagag cggcaacagc     1320

caggaaagcg tgaccgagca ggacagcaag gactccacct acagcctgag cagcaccctg     1380

accctgagca aggccgacta cgagaagcac aaggtgtacg cctgcgaagt gacccaccag     1440

ggcctgtcta gccccgtgac caagagcttc aaccggggcg agtgcgacaa gacccacacc     1500

tgtcctccat gccctgcccc tgaagctgct ggcggcccta gcgtgttcct gttcccccca     1560

aagcccaagg acaccctgat gatcagccgg acccctgaag tgacctgcgt ggtggtggat     1620

gtgtcccacg aggaccctga agtgaagttc aattggtacg tggacggcgt ggaagtgcac     1680

aatgccaaga ccaagccgcg ggaggagcag tacaacagca cgtaccgtgt ggtcagcgtc     1740

ctcaccgtcc tgcaccagga ctggctgaat ggcaaggagt acaagtgcaa ggtctccaac     1800

aaagccctcg gcgcccccat cgagaaaacc atctccaaag ccaaagggca gccccgagaa     1860

ccacaggtgt acaccctgcc cccatgccgg gatgagctga ccaagaacca ggtcagcctg     1920

tggtgcctgg tcaaaggctt ctatcccagc gacatcgccg tggagtggga gagcaatggg     1980

cagccggaga acaactacaa gaccacgcct cccgtgctgg actccgacgg ctccttcttc     2040

ctctacagca agctcaccgt ggacaagagc aggtggcagc aggggaacgt cttctcatgc     2100

tccgtgatgc atgaggctct gcacaaccac tacacgcaga agagcctctc cctgtctccg     2160

ggtaaa                                                                2166


<210>  99
<211>  891
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Monomeric ligand (71-254)-CH1*

<400>  99
agagagggcc ctgagctgag ccccgatgat cctgctggac tgctggacct gcggcagggc       60

atgtttgctc agctggtggc ccagaacgtg ctgctgatcg atggccccct gtcctggtac      120

agcgatcctg gactggctgg cgtgtcactg acaggcggcc tgagctacaa agaggacacc      180

aaagaactgg tggtggccaa ggccggcgtg tactacgtgt tctttcagct ggaactgcgg      240

agagtggtgg ccggcgaagg atctggctct gtgtctctgg ccctgcatct gcagcctctg      300

agaagcgctg ctggcgctgc agctctggct ctgacagtgg atctgcctcc tgccagctcc      360

gaggcccgga atagcgcatt tgggtttcaa ggccggctgc tgcacctgtc tgccggccag      420

agactgggag tgcatctgca cacagaggcc agagccaggc acgcctggca gctgacacag      480

ggcgctacag tgctgggcct gttcagagtg acccccgaga ttcctgccgg cctgcctagc      540

cctagatctg aaggcggcgg aggttccgga ggcggaggat ctgctagcac aaagggcccc      600

agcgtgttcc ctctggcccc tagcagcaag agcacatctg gcggaacagc cgccctgggc      660

tgcctggtgg aagattactt ccccgagccc gtgaccgtgt cctggaattc tggcgccctg      720

acaagcggcg tgcacacctt tccagccgtg ctgcagagca gcggcctgta ctctctgagc      780

agcgtcgtga cagtgcccag cagctctctg ggcacccaga cctacatctg caacgtgaac      840

cacaagccca gcaacaccaa ggtggacgag aaggtggaac ccaagtcctg c               891


<210>  100
<211>  1344
<212>  DNA
<213>  Artificial sequence

<220>
<223>  anti-TnC(18D4) Fc hole chain

<400>  100
caggtgcaat tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cctccggagg cacattcagc agctacgcta taagctgggt gcgacaggcc      120

cctggacaag ggctcgagtg gatgggaggg atcatcccta tctttggtac agcaaactac      180

gcacagaagt tccagggcag ggtcaccatt actgcagaca aatccacgag cacagcctac      240

atggagctga gcagcctgag atctgaggac accgccgtgt attactgtgc gaaaggtaac      300

ttctacggtg gtctggacta ctggggccaa gggaccaccg tgaccgtctc ctcagctagc      360

accaagggcc cctccgtgtt ccccctggcc cccagcagca agagcaccag cggcggcaca      420

gccgctctgg gctgcctggt caaggactac ttccccgagc ccgtgaccgt gtcctggaac      480

agcggagccc tgacctccgg cgtgcacacc ttccccgccg tgctgcagag ttctggcctg      540

tatagcctga gcagcgtggt caccgtgcct tctagcagcc tgggcaccca gacctacatc      600

tgcaacgtga accacaagcc cagcaacacc aaggtggaca agaaggtgga gcccaagagc      660

tgcgacaaaa ctcacacatg cccaccgtgc ccagcacctg aagctgcagg gggaccgtca      720

gtcttcctct tccccccaaa acccaaggac accctcatga tctcccggac ccctgaggtc      780

acatgcgtgg tggtggacgt gagccacgaa gaccctgagg tcaagttcaa ctggtacgtg      840

gacggcgtgg aggtgcataa tgccaagaca aagccgcggg aggagcagta caacagcacg      900

taccgtgtgg tcagcgtcct caccgtcctg caccaggact ggctgaatgg caaggagtac      960

aagtgcaagg tctccaacaa agccctcggc gcccccatcg agaaaaccat ctccaaagcc     1020

aaagggcagc cccgagaacc acaggtgtgc accctgcccc catcccggga tgagctgacc     1080

aagaaccagg tcagcctctc gtgcgcagtc aaaggcttct atcccagcga catcgccgtg     1140

gagtgggaga gcaatgggca gccggagaac aactacaaga ccacgcctcc cgtgctggac     1200

tccgacggct ccttcttcct cgtgagcaag ctcaccgtgg acaagagcag gtggcagcag     1260

gggaacgtct tctcatgctc cgtgatgcat gaggctctgc acaaccacta cacgcagaag     1320

agcctctccc tgtctccggg taaa                                            1344


<210>  101
<211>  10
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Randomized sequence 1


<220>
<221>  misc_feature
<222>  (1)..(10)
<223>  n is a, c, g, or t

<400>  101
nnnnnnnnnn                                                              10


<210>  102
<211>  722
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Dimeric ligand (71-254) - CL* Fc knob chain

<400>  102

Arg Glu Gly Pro Glu Leu Ser Pro Asp Asp Pro Ala Gly Leu Leu Asp 
1               5                   10                  15      


Leu Arg Gln Gly Met Phe Ala Gln Leu Val Ala Gln Asn Val Leu Leu 
            20                  25                  30          


Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala Gly Val 
        35                  40                  45              


Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu Asp Thr Lys Glu Leu Val 
    50                  55                  60                  


Val Ala Lys Ala Gly Val Tyr Tyr Val Phe Phe Gln Leu Glu Leu Arg 
65                  70                  75                  80  


Arg Val Val Ala Gly Glu Gly Ser Gly Ser Val Ser Leu Ala Leu His 
                85                  90                  95      


Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala Leu Thr 
            100                 105                 110         


Val Asp Leu Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala Phe Gly 
        115                 120                 125             


Phe Gln Gly Arg Leu Leu His Leu Ser Ala Gly Gln Arg Leu Gly Val 
    130                 135                 140                 


His Leu His Thr Glu Ala Arg Ala Arg His Ala Trp Gln Leu Thr Gln 
145                 150                 155                 160 


Gly Ala Thr Val Leu Gly Leu Phe Arg Val Thr Pro Glu Ile Pro Ala 
                165                 170                 175     


Gly Leu Pro Ser Pro Arg Ser Glu Gly Gly Gly Gly Ser Gly Gly Gly 
            180                 185                 190         


Gly Ser Arg Glu Gly Pro Glu Leu Ser Pro Asp Asp Pro Ala Gly Leu 
        195                 200                 205             


Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu Val Ala Gln Asn Val 
    210                 215                 220                 


Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala 
225                 230                 235                 240 


Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu Asp Thr Lys Glu 
                245                 250                 255     


Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe Phe Gln Leu Glu 
            260                 265                 270         


Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser Val Ser Leu Ala 
        275                 280                 285             


Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala 
    290                 295                 300                 


Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala 
305                 310                 315                 320 


Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala Gly Gln Arg Leu 
                325                 330                 335     


Gly Val His Leu His Thr Glu Ala Arg Ala Arg His Ala Trp Gln Leu 
            340                 345                 350         


Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val Thr Pro Glu Ile 
        355                 360                 365             


Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu Gly Gly Gly Gly Ser Gly 
    370                 375                 380                 


Gly Gly Gly Ser Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro 
385                 390                 395                 400 


Pro Ser Asp Arg Lys Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu 
                405                 410                 415     


Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp 
            420                 425                 430         


Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp 
        435                 440                 445             


Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys 
    450                 455                 460                 


Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln 
465                 470                 475                 480 


Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys Asp 
                485                 490                 495     


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly 
            500                 505                 510         


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
        515                 520                 525             


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
    530                 535                 540                 


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
545                 550                 555                 560 


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
                565                 570                 575     


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
            580                 585                 590         


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Gly Ala Pro Ile Glu 
        595                 600                 605             


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
    610                 615                 620                 


Thr Leu Pro Pro Cys Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
625                 630                 635                 640 


Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
                645                 650                 655     


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
            660                 665                 670         


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
        675                 680                 685             


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
    690                 695                 700                 


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
705                 710                 715                 720 


Gly Lys 
        


<210>  103
<211>  297
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Monomeric ligand (71-254)-CH1*

<400>  103

Arg Glu Gly Pro Glu Leu Ser Pro Asp Asp Pro Ala Gly Leu Leu Asp 
1               5                   10                  15      


Leu Arg Gln Gly Met Phe Ala Gln Leu Val Ala Gln Asn Val Leu Leu 
            20                  25                  30          


Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala Gly Val 
        35                  40                  45              


Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu Asp Thr Lys Glu Leu Val 
    50                  55                  60                  


Val Ala Lys Ala Gly Val Tyr Tyr Val Phe Phe Gln Leu Glu Leu Arg 
65                  70                  75                  80  


Arg Val Val Ala Gly Glu Gly Ser Gly Ser Val Ser Leu Ala Leu His 
                85                  90                  95      


Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala Leu Thr 
            100                 105                 110         


Val Asp Leu Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala Phe Gly 
        115                 120                 125             


Phe Gln Gly Arg Leu Leu His Leu Ser Ala Gly Gln Arg Leu Gly Val 
    130                 135                 140                 


His Leu His Thr Glu Ala Arg Ala Arg His Ala Trp Gln Leu Thr Gln 
145                 150                 155                 160 


Gly Ala Thr Val Leu Gly Leu Phe Arg Val Thr Pro Glu Ile Pro Ala 
                165                 170                 175     


Gly Leu Pro Ser Pro Arg Ser Glu Gly Gly Gly Gly Ser Gly Gly Gly 
            180                 185                 190         


Gly Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser 
        195                 200                 205             


Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Glu 
    210                 215                 220                 


Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu 
225                 230                 235                 240 


Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu 
                245                 250                 255     


Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr 
            260                 265                 270         


Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val 
        275                 280                 285             


Asp Glu Lys Val Glu Pro Lys Ser Cys 
    290                 295         


<210>  104
<211>  448
<212>  PRT
<213>  Artificial sequence

<220>
<223>  anti-TnC(18D4) Fc hole chain

<400>  104

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Asn Phe Tyr Gly Gly Leu Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr 
    210                 215                 220                 


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser 
225                 230                 235                 240 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                245                 250                 255     


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
            260                 265                 270         


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        275                 280                 285             


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
    290                 295                 300                 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
305                 310                 315                 320 


Lys Cys Lys Val Ser Asn Lys Ala Leu Gly Ala Pro Ile Glu Lys Thr 
                325                 330                 335     


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Cys Thr Leu 
            340                 345                 350         


Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Ser Cys 
        355                 360                 365             


Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    370                 375                 380                 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
385                 390                 395                 400 


Ser Asp Gly Ser Phe Phe Leu Val Ser Lys Leu Thr Val Asp Lys Ser 
                405                 410                 415     


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            420                 425                 430         


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445             


<210>  105
<211>  11
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Randomized sequence 2


<220>
<221>  misc_feature
<222>  (1)..(11)
<223>  n is a, c, g, or t

<400>  105
nnnnnnnnnn n                                                            11


<210>  106
<211>  2166
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Dimeric ligand (71-254)- CL Fc knob chain

<400>  106
agagagggcc ctgagctgag ccccgatgat cctgctggac tgctggacct gcggcagggc       60

atgtttgctc agctggtggc ccagaacgtg ctgctgatcg atggccccct gtcctggtac      120

agcgatcctg gactggctgg cgtgtcactg acaggcggcc tgagctacaa agaggacacc      180

aaagaactgg tggtggccaa ggccggcgtg tactacgtgt tctttcagct ggaactgcgg      240

agagtggtgg ccggcgaagg atctggctct gtgtctctgg ccctgcatct gcagcctctg      300

agaagcgctg ctggcgctgc agctctggca ctgacagtgg atctgcctcc tgccagctcc      360

gaggcccgga atagcgcatt tgggtttcaa ggcaggctgc tgcacctgtc tgccggccag      420

aggctgggag tgcatctgca cacagaggcc agggctagac acgcctggca gctgacacag      480

ggcgctacag tgctgggcct gttcagagtg acccccgaga ttccagccgg cctgccttct      540

ccaagaagcg aaggcggagg cggatctggc ggcggaggat ctagagaggg acccgaactg      600

tcccctgacg atccagccgg gctgctggat ctgagacagg gaatgttcgc ccagctggtg      660

gctcagaatg tgctgctgat tgacggacct ctgagctggt actccgaccc agggctggca      720

ggggtgtccc tgactggggg actgtcctac aaagaagata caaaagaact ggtggtggct      780

aaagctgggg tgtactatgt gttttttcag ctggaactga ggcgggtggt ggctggggag      840

ggctcaggat ctgtgtccct ggctctgcat ctgcagccac tgcgctctgc tgctggcgca      900

gctgcactgg ctctgactgt ggacctgcca ccagcctcta gcgaggccag aaacagcgcc      960

ttcgggttcc aaggacgcct gctgcatctg agcgccggac agcgcctggg agtgcatctg     1020

catactgaag ccagagcccg gcatgcttgg cagctgactc agggggcaac tgtgctggga     1080

ctgtttcgcg tgacacctga gatccctgcc ggactgccaa gccctagatc agaagggggc     1140

ggaggttccg gagggggagg atctcgtacg gtggccgctc cctccgtgtt tatctttccc     1200

ccatccgatg aacagctgaa aagcggcacc gcctccgtcg tgtgtctgct gaacaatttt     1260

taccctaggg aagctaaagt gcagtggaaa gtggataacg cactgcagtc cggcaactcc     1320

caggaatctg tgacagaaca ggactccaag gacagcacct actccctgtc ctccaccctg     1380

acactgtcta aggctgatta tgagaaacac aaagtctacg cctgcgaagt cacccatcag     1440

ggcctgagct cgcccgtcac aaagagcttc aacaggggag agtgtgacaa gacccacacc     1500

tgtccccctt gtcctgcccc tgaagctgct ggcggccctt ctgtgttcct gttcccccca     1560

aagcccaagg acaccctgat gatcagccgg acccccgaag tgacctgcgt ggtggtggat     1620

gtgtcccacg aggaccctga agtgaagttc aattggtacg tggacggcgt ggaagtgcac     1680

aatgccaaga ccaagccgcg ggaggagcag tacaacagca cgtaccgtgt ggtcagcgtc     1740

ctcaccgtcc tgcaccagga ctggctgaat ggcaaggagt acaagtgcaa ggtctccaac     1800

aaagccctcg gcgcccccat cgagaaaacc atctccaaag ccaaagggca gccccgagaa     1860

ccacaggtgt acaccctgcc cccatgccgg gatgagctga ccaagaacca ggtcagcctg     1920

tggtgcctgg tcaaaggctt ctatcccagc gacatcgccg tggagtggga gagcaatggg     1980

cagccggaga acaactacaa gaccacgcct cccgtgctgg actccgacgg ctccttcttc     2040

ctctacagca agctcaccgt ggacaagagc aggtggcagc aggggaacgt cttctcatgc     2100

tccgtgatgc atgaggctct gcacaaccac tacacgcaga agagcctctc cctgtctccg     2160

ggtaaa                                                                2166


<210>  107
<211>  891
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Monomeric ligand (71-254)-CH1

<400>  107
agagagggcc ctgagctgag ccccgatgat cctgctggac tgctggacct gcggcagggc       60

atgtttgctc agctggtggc ccagaacgtg ctgctgatcg atggccccct gtcctggtac      120

agcgatcctg gactggctgg cgtgtcactg acaggcggcc tgagctacaa agaggacacc      180

aaagaactgg tggtggccaa ggccggcgtg tactacgtgt tctttcagct ggaactgcgg      240

agagtggtgg ccggcgaagg atctggctct gtgtctctgg ccctgcatct gcagcctctg      300

agaagcgctg ctggcgctgc agctctggct ctgacagtgg atctgcctcc tgccagctcc      360

gaggcccgga atagcgcatt tgggtttcaa ggccggctgc tgcacctgtc tgccggccag      420

agactgggag tgcatctgca cacagaggcc agagccaggc acgcctggca gctgacacag      480

ggcgctacag tgctgggcct gttcagagtg acccccgaga ttcctgccgg cctgcctagc      540

cctagatctg aaggcggcgg aggttccgga ggcggaggat ctgctagcac caaaggccct      600

tccgtgtttc ctctggctcc tagctccaag tccacctctg gaggcaccgc tgctctcgga      660

tgcctcgtga aggattattt tcctgagcct gtgacagtgt cctggaatag cggagcactg      720

acctctggag tgcatacttt ccccgctgtg ctgcagtcct ctggactgta cagcctgagc      780

agcgtggtga cagtgcccag cagcagcctg ggcacccaga cctacatctg caacgtgaac      840

cacaagccca gcaacaccaa ggtggacaag aaggtggaac ccaagtcttg t               891


<210>  108
<211>  722
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Dimeric ligand (71-254) - CL Fc knob chain

<400>  108

Arg Glu Gly Pro Glu Leu Ser Pro Asp Asp Pro Ala Gly Leu Leu Asp 
1               5                   10                  15      


Leu Arg Gln Gly Met Phe Ala Gln Leu Val Ala Gln Asn Val Leu Leu 
            20                  25                  30          


Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala Gly Val 
        35                  40                  45              


Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu Asp Thr Lys Glu Leu Val 
    50                  55                  60                  


Val Ala Lys Ala Gly Val Tyr Tyr Val Phe Phe Gln Leu Glu Leu Arg 
65                  70                  75                  80  


Arg Val Val Ala Gly Glu Gly Ser Gly Ser Val Ser Leu Ala Leu His 
                85                  90                  95      


Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala Leu Thr 
            100                 105                 110         


Val Asp Leu Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala Phe Gly 
        115                 120                 125             


Phe Gln Gly Arg Leu Leu His Leu Ser Ala Gly Gln Arg Leu Gly Val 
    130                 135                 140                 


His Leu His Thr Glu Ala Arg Ala Arg His Ala Trp Gln Leu Thr Gln 
145                 150                 155                 160 


Gly Ala Thr Val Leu Gly Leu Phe Arg Val Thr Pro Glu Ile Pro Ala 
                165                 170                 175     


Gly Leu Pro Ser Pro Arg Ser Glu Gly Gly Gly Gly Ser Gly Gly Gly 
            180                 185                 190         


Gly Ser Arg Glu Gly Pro Glu Leu Ser Pro Asp Asp Pro Ala Gly Leu 
        195                 200                 205             


Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu Val Ala Gln Asn Val 
    210                 215                 220                 


Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala 
225                 230                 235                 240 


Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu Asp Thr Lys Glu 
                245                 250                 255     


Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe Phe Gln Leu Glu 
            260                 265                 270         


Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser Val Ser Leu Ala 
        275                 280                 285             


Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala 
    290                 295                 300                 


Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala 
305                 310                 315                 320 


Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala Gly Gln Arg Leu 
                325                 330                 335     


Gly Val His Leu His Thr Glu Ala Arg Ala Arg His Ala Trp Gln Leu 
            340                 345                 350         


Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val Thr Pro Glu Ile 
        355                 360                 365             


Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu Gly Gly Gly Gly Ser Gly 
    370                 375                 380                 


Gly Gly Gly Ser Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro 
385                 390                 395                 400 


Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu 
                405                 410                 415     


Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp 
            420                 425                 430         


Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp 
        435                 440                 445             


Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys 
    450                 455                 460                 


Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln 
465                 470                 475                 480 


Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys Asp 
                485                 490                 495     


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly 
            500                 505                 510         


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
        515                 520                 525             


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
    530                 535                 540                 


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
545                 550                 555                 560 


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
                565                 570                 575     


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
            580                 585                 590         


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Gly Ala Pro Ile Glu 
        595                 600                 605             


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
    610                 615                 620                 


Thr Leu Pro Pro Cys Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
625                 630                 635                 640 


Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
                645                 650                 655     


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
            660                 665                 670         


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
        675                 680                 685             


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
    690                 695                 700                 


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
705                 710                 715                 720 


Gly Lys 
        


<210>  109
<211>  297
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Monomeric ligand (71-254) -CH1

<400>  109

Arg Glu Gly Pro Glu Leu Ser Pro Asp Asp Pro Ala Gly Leu Leu Asp 
1               5                   10                  15      


Leu Arg Gln Gly Met Phe Ala Gln Leu Val Ala Gln Asn Val Leu Leu 
            20                  25                  30          


Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala Gly Val 
        35                  40                  45              


Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu Asp Thr Lys Glu Leu Val 
    50                  55                  60                  


Val Ala Lys Ala Gly Val Tyr Tyr Val Phe Phe Gln Leu Glu Leu Arg 
65                  70                  75                  80  


Arg Val Val Ala Gly Glu Gly Ser Gly Ser Val Ser Leu Ala Leu His 
                85                  90                  95      


Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala Leu Thr 
            100                 105                 110         


Val Asp Leu Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala Phe Gly 
        115                 120                 125             


Phe Gln Gly Arg Leu Leu His Leu Ser Ala Gly Gln Arg Leu Gly Val 
    130                 135                 140                 


His Leu His Thr Glu Ala Arg Ala Arg His Ala Trp Gln Leu Thr Gln 
145                 150                 155                 160 


Gly Ala Thr Val Leu Gly Leu Phe Arg Val Thr Pro Glu Ile Pro Ala 
                165                 170                 175     


Gly Leu Pro Ser Pro Arg Ser Glu Gly Gly Gly Gly Ser Gly Gly Gly 
            180                 185                 190         


Gly Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser 
        195                 200                 205             


Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys 
    210                 215                 220                 


Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu 
225                 230                 235                 240 


Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu 
                245                 250                 255     


Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr 
            260                 265                 270         


Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val 
        275                 280                 285             


Asp Lys Lys Val Glu Pro Lys Ser Cys 
    290                 295         


<210>  110
<211>  2505
<212>  DNA
<213>  Artificial sequence

<220>
<223>  anti-TnC(18D4) Fc hole dimeric ligand (71-254) chain

<400>  110
caggtgcaat tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cctccggagg cacattcagc agctacgcta taagctgggt gcgacaggcc      120

cctggacaag ggctcgagtg gatgggaggg atcatcccta tctttggtac agcaaactac      180

gcacagaagt tccagggcag ggtcaccatt actgcagaca aatccacgag cacagcctac      240

atggagctga gcagcctgag atctgaggac accgccgtgt attactgtgc gaaaggtaac      300

ttctacggtg gtctggacta ctggggccaa gggaccaccg tgaccgtctc ctcagctagc      360

accaagggcc cctccgtgtt ccccctggcc cccagcagca agagcaccag cggcggcaca      420

gccgctctgg gctgcctggt caaggactac ttccccgagc ccgtgaccgt gtcctggaac      480

agcggagccc tgacctccgg cgtgcacacc ttccccgccg tgctgcagag ttctggcctg      540

tatagcctga gcagcgtggt caccgtgcct tctagcagcc tgggcaccca gacctacatc      600

tgcaacgtga accacaagcc cagcaacacc aaggtggaca agaaggtgga gcccaagagc      660

tgcgacaaaa ctcacacatg cccaccgtgc ccagcacctg aagctgcagg gggaccgtca      720

gtcttcctct tccccccaaa acccaaggac accctcatga tctcccggac ccctgaggtc      780

acatgcgtgg tggtggacgt gagccacgaa gaccctgagg tcaagttcaa ctggtacgtg      840

gacggcgtgg aggtgcataa tgccaagaca aagccgcggg aggagcagta caacagcacg      900

taccgtgtgg tcagcgtcct caccgtcctg caccaggact ggctgaatgg caaggagtac      960

aagtgcaagg tctccaacaa agccctcggc gcccccatcg agaaaaccat ctccaaagcc     1020

aaagggcagc cccgagaacc acaggtgtgc accctgcccc catcccggga tgagctgacc     1080

aagaaccagg tcagcctctc gtgcgcagtc aaaggcttct atcccagcga catcgccgtg     1140

gagtgggaga gcaatgggca gccggagaac aactacaaga ccacgcctcc cgtgctggac     1200

tccgacggct ccttcttcct cgtgagcaag ctcaccgtgg acaagagcag gtggcagcag     1260

gggaacgtct tctcatgctc cgtgatgcat gaggctctgc acaaccacta cacgcagaag     1320

agcctctccc tgtctccggg tggaggcggc ggaagcggag gaggaggatc cagagagggc     1380

cctgagctga gccccgatga tcctgctgga ctgctggacc tgcggcaggg catgtttgct     1440

cagctggtgg cccagaacgt gctgctgatc gatggccccc tgtcctggta cagcgatcct     1500

ggactggctg gcgtgtcact gacaggcggc ctgagctaca aagaggacac caaagaactg     1560

gtggtggcca aggccggcgt gtactacgtg ttctttcagc tggaactgcg gagagtggtg     1620

gccggcgaag gatctggctc tgtgtctctg gccctgcatc tgcagcctct gagaagcgct     1680

gctggcgctg cagctctggc actgacagtg gatctgcctc ctgccagctc cgaggcccgg     1740

aatagcgcat ttgggtttca aggcaggctg ctgcacctgt ctgccggcca gaggctggga     1800

gtgcatctgc acacagaggc cagggctaga cacgcctggc agctgacaca gggcgctaca     1860

gtgctgggcc tgttcagagt gacccccgag attccagccg gcctgccttc tccaagaagc     1920

gaaggcggag gcggatctgg cggcggagga tctagagagg gacccgaact gtcccctgac     1980

gatccagccg ggctgctgga tctgagacag ggaatgttcg cccagctggt ggctcagaat     2040

gtgctgctga ttgacggacc tctgagctgg tactccgacc cagggctggc aggggtgtcc     2100

ctgactgggg gactgtccta caaagaagat acaaaagaac tggtggtggc taaagctggg     2160

gtgtactatg tgttttttca gctggaactg aggcgggtgg tggctgggga gggctcagga     2220

tctgtgtccc tggctctgca tctgcagcca ctgcgctctg ctgctggcgc agctgcactg     2280

gctctgactg tggacctgcc accagcctct agcgaggcca gaaacagcgc cttcgggttc     2340

caaggacgcc tgctgcatct gagcgccgga cagcgcctgg gagtgcatct gcatactgaa     2400

gccagagccc ggcatgcttg gcagctgact cagggggcaa ctgtgctggg actgtttcgc     2460

gtgacacctg agatccctgc cggactgcca agccctagat cagaa                     2505


<210>  111
<211>  1923
<212>  DNA
<213>  Artificial sequence

<220>
<223>  anti-TnC(18D4) Fc knob monomeric ligand (71-254) chain

<400>  111
caggtgcaat tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cctccggagg cacattcagc agctacgcta taagctgggt gcgacaggcc      120

cctggacaag ggctcgagtg gatgggaggg atcatcccta tctttggtac agcaaactac      180

gcacagaagt tccagggcag ggtcaccatt actgcagaca aatccacgag cacagcctac      240

atggagctga gcagcctgag atctgaggac accgccgtgt attactgtgc gaaaggtaac      300

ttctacggtg gtctggacta ctggggccaa gggaccaccg tgaccgtctc ctcagctagc      360

accaagggcc catcggtctt ccccctggca ccctcctcca agagcacctc tgggggcaca      420

gcggccctgg gctgcctggt caaggactac ttccccgaac cggtgacggt gtcgtggaac      480

tcaggcgccc tgaccagcgg cgtgcacacc ttcccggctg tcctacagtc ctcaggactc      540

tactccctca gcagcgtggt gaccgtgccc tccagcagct tgggcaccca gacctacatc      600

tgcaacgtga atcacaagcc cagcaacacc aaggtggaca agaaagttga gcccaaatct      660

tgtgacaaaa ctcacacatg cccaccgtgc ccagcacctg aagctgcagg gggaccgtca      720

gtcttcctct tccccccaaa acccaaggac accctcatga tctcccggac ccctgaggtc      780

acatgcgtgg tggtggacgt gagccacgaa gaccctgagg tcaagttcaa ctggtacgtg      840

gacggcgtgg aggtgcataa tgccaagaca aagccgcggg aggagcagta caacagcacg      900

taccgtgtgg tcagcgtcct caccgtcctg caccaggact ggctgaatgg caaggagtac      960

aagtgcaagg tctccaacaa agccctcggc gcccccatcg agaaaaccat ctccaaagcc     1020

aaagggcagc cccgagaacc acaggtgtac accctgcccc cctgcagaga tgagctgacc     1080

aagaaccagg tgtccctgtg gtgtctggtc aagggcttct accccagcga tatcgccgtg     1140

gagtgggaga gcaacggcca gcctgagaac aactacaaga ccaccccccc tgtgctggac     1200

agcgacggca gcttcttcct gtactccaaa ctgaccgtgg acaagagccg gtggcagcag     1260

ggcaacgtgt tcagctgcag cgtgatgcac gaggccctgc acaaccacta cacccagaag     1320

tccctgagcc tgagccccgg cggaggcggc ggaagcggag gaggaggatc cagagagggc     1380

cctgagctga gccccgatga tcctgctgga ctgctggacc tgcggcaggg catgtttgct     1440

cagctggtgg cccagaacgt gctgctgatc gatggccccc tgtcctggta cagcgatcct     1500

ggactggctg gcgtgtcact gacaggcggc ctgagctaca aagaggacac caaagaactg     1560

gtggtggcca aggccggcgt gtactacgtg ttctttcagc tggaactgcg gagagtggtg     1620

gccggcgaag gatctggctc tgtgtctctg gccctgcatc tgcagcctct gagaagcgct     1680

gctggcgctg cagctctggc actgacagtg gatctgcctc ctgccagctc cgaggcccgg     1740

aatagcgcat ttgggtttca aggcaggctg ctgcacctgt ctgccggcca gaggctggga     1800

gtgcatctgc acacagaggc cagggctaga cacgcctggc agctgacaca gggcgctaca     1860

gtgctgggcc tgttcagagt gacccccgag attccagccg gcctgccttc tccaagaagc     1920

gaa                                                                   1923


<210>  112
<211>  835
<212>  PRT
<213>  Artificial sequence

<220>
<223>  anti-TnC(18D4) Fc hole dimeric ligand (71-254)  chain

<400>  112

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Asn Phe Tyr Gly Gly Leu Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr 
    210                 215                 220                 


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser 
225                 230                 235                 240 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                245                 250                 255     


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
            260                 265                 270         


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        275                 280                 285             


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
    290                 295                 300                 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
305                 310                 315                 320 


Lys Cys Lys Val Ser Asn Lys Ala Leu Gly Ala Pro Ile Glu Lys Thr 
                325                 330                 335     


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Cys Thr Leu 
            340                 345                 350         


Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Ser Cys 
        355                 360                 365             


Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    370                 375                 380                 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
385                 390                 395                 400 


Ser Asp Gly Ser Phe Phe Leu Val Ser Lys Leu Thr Val Asp Lys Ser 
                405                 410                 415     


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            420                 425                 430         


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Gly 
        435                 440                 445             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Arg Glu Gly Pro Glu Leu Ser 
    450                 455                 460                 


Pro Asp Asp Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala 
465                 470                 475                 480 


Gln Leu Val Ala Gln Asn Val Leu Leu Ile Asp Gly Pro Leu Ser Trp 
                485                 490                 495     


Tyr Ser Asp Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser 
            500                 505                 510         


Tyr Lys Glu Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr 
        515                 520                 525             


Tyr Val Phe Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly 
    530                 535                 540                 


Ser Gly Ser Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala 
545                 550                 555                 560 


Ala Gly Ala Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser 
                565                 570                 575     


Ser Glu Ala Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His 
            580                 585                 590         


Leu Ser Ala Gly Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg 
        595                 600                 605             


Ala Arg His Ala Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu 
    610                 615                 620                 


Phe Arg Val Thr Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser 
625                 630                 635                 640 


Glu Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Arg Glu Gly Pro Glu 
                645                 650                 655     


Leu Ser Pro Asp Asp Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met 
            660                 665                 670         


Phe Ala Gln Leu Val Ala Gln Asn Val Leu Leu Ile Asp Gly Pro Leu 
        675                 680                 685             


Ser Trp Tyr Ser Asp Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly 
    690                 695                 700                 


Leu Ser Tyr Lys Glu Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly 
705                 710                 715                 720 


Val Tyr Tyr Val Phe Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly 
                725                 730                 735     


Glu Gly Ser Gly Ser Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg 
            740                 745                 750         


Ser Ala Ala Gly Ala Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro 
        755                 760                 765             


Ala Ser Ser Glu Ala Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu 
    770                 775                 780                 


Leu His Leu Ser Ala Gly Gln Arg Leu Gly Val His Leu His Thr Glu 
785                 790                 795                 800 


Ala Arg Ala Arg His Ala Trp Gln Leu Thr Gln Gly Ala Thr Val Leu 
                805                 810                 815     


Gly Leu Phe Arg Val Thr Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro 
            820                 825                 830         


Arg Ser Glu 
        835 


<210>  113
<211>  641
<212>  PRT
<213>  Artificial sequence

<220>
<223>  anti-TnC(18D4) Fc knob monomeric ligand (71-254) chain

<400>  113

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Asn Phe Tyr Gly Gly Leu Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr 
    210                 215                 220                 


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser 
225                 230                 235                 240 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                245                 250                 255     


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
            260                 265                 270         


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        275                 280                 285             


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
    290                 295                 300                 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
305                 310                 315                 320 


Lys Cys Lys Val Ser Asn Lys Ala Leu Gly Ala Pro Ile Glu Lys Thr 
                325                 330                 335     


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            340                 345                 350         


Pro Pro Cys Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Trp Cys 
        355                 360                 365             


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    370                 375                 380                 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
385                 390                 395                 400 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
                405                 410                 415     


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            420                 425                 430         


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Gly 
        435                 440                 445             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Arg Glu Gly Pro Glu Leu Ser 
    450                 455                 460                 


Pro Asp Asp Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala 
465                 470                 475                 480 


Gln Leu Val Ala Gln Asn Val Leu Leu Ile Asp Gly Pro Leu Ser Trp 
                485                 490                 495     


Tyr Ser Asp Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser 
            500                 505                 510         


Tyr Lys Glu Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr 
        515                 520                 525             


Tyr Val Phe Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly 
    530                 535                 540                 


Ser Gly Ser Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala 
545                 550                 555                 560 


Ala Gly Ala Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser 
                565                 570                 575     


Ser Glu Ala Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His 
            580                 585                 590         


Leu Ser Ala Gly Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg 
        595                 600                 605             


Ala Arg His Ala Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu 
    610                 615                 620                 


Phe Arg Val Thr Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser 
625                 630                 635                 640 


Glu 
    


<210>  114
<211>  2130
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Dimeric ligand (71-248) - CL* Fc knob chain

<400>  114
agagagggcc ctgagctgag ccccgatgat cctgctggac tgctggacct gcggcagggc       60

atgtttgctc agctggtggc ccagaacgtg ctgctgatcg atggccccct gtcctggtac      120

agcgatcctg gactggctgg cgtgtcactg acaggcggcc tgagctacaa agaggacacc      180

aaagaactgg tggtggccaa ggccggcgtg tactacgtgt tctttcagct ggaactgcgg      240

agagtggtgg ccggcgaagg atctggctct gtgtctctgg ccctgcatct gcagcctctg      300

agatctgctg ctggcgccgc tgctctggca ctgacagtgg atctgcctcc tgccagcagc      360

gaggcccgga atagcgcatt tgggtttcaa ggcaggctgc tgcacctgtc tgccggccag      420

aggctgggag tgcatctgca cacagaggcc agggctagac acgcctggca gctgacacag      480

ggcgctacag tgctgggcct gttcagagtg acccccgaga ttccagccgg actgggaggc      540

ggcggatctg gcggcggagg atctagagaa ggacccgagc tgtcccctga cgatccagcc      600

gggctgctgg atctgagaca gggaatgttc gcccagctgg tggctcagaa tgtgctgctg      660

attgacggac ctctgagctg gtactccgac ccagggctgg caggggtgtc cctgactggg      720

ggactgtcct acaaagaaga tacaaaagaa ctggtggtgg ctaaagctgg ggtgtactat      780

gtgttttttc agctggaact gaggcgggtg gtggctgggg agggctcagg atctgtgtcc      840

ctggctctgc atctgcagcc actgcgctct gcagcagggg ctgcagcact ggccctgact      900

gtggacctgc ccccagcttc ttccgaggcc agaaacagcg ccttcgggtt ccaaggacgc      960

ctgctgcatc tgagcgccgg acagcgcctg ggagtgcatc tgcatactga agccagagcc     1020

cggcatgctt ggcagctgac tcagggggca actgtgctgg gactgtttcg cgtgacacct     1080

gagatccccg ctggactggg cggaggcggt tccggagggg gaggatctcg tacggtggct     1140

gcaccatctg tctttatctt cccacccagc gaccggaagc tgaagtctgg cacagccagc     1200

gtcgtgtgcc tgctgaataa cttctacccc cgcgaggcca aggtgcagtg gaaggtggac     1260

aatgccctgc agagcggcaa cagccaggaa agcgtgaccg agcaggacag caaggactcc     1320

acctacagcc tgagcagcac cctgaccctg agcaaggccg actacgagaa gcacaaggtg     1380

tacgcctgcg aagtgaccca ccagggcctg tctagccccg tgaccaagag cttcaaccgg     1440

ggcgagtgcg acaagaccca cacctgtcct ccatgccctg cccctgaagc tgctggcggc     1500

cctagcgtgt tcctgttccc cccaaagccc aaggacaccc tgatgatcag ccggacccct     1560

gaagtgacct gcgtggtggt ggatgtgtcc cacgaggacc ctgaagtgaa gttcaattgg     1620

tacgtggacg gcgtggaagt gcacaatgcc aagaccaagc cgcgggagga gcagtacaac     1680

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag     1740

gagtacaagt gcaaggtctc caacaaagcc ctcggcgccc ccatcgagaa aaccatctcc     1800

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatg ccgggatgag     1860

ctgaccaaga accaggtcag cctgtggtgc ctggtcaaag gcttctatcc cagcgacatc     1920

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg     1980

ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg     2040

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg     2100

cagaagagcc tctccctgtc tccgggtaaa                                      2130


<210>  115
<211>  873
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Monomeric ligand (71-248)-CH1*

<400>  115
agagagggcc ctgagctgag ccccgatgat cctgctggac tgctggacct gcggcagggc       60

atgtttgctc agctggtggc ccagaacgtg ctgctgatcg atggccccct gtcctggtac      120

agcgatcctg gactggctgg cgtgtcactg acaggcggcc tgagctacaa agaggacacc      180

aaagaactgg tggtggccaa ggccggcgtg tactacgtgt tctttcagct ggaactgcgg      240

agagtggtgg ccggcgaagg atctggctct gtgtctctgg ccctgcatct gcagcctctg      300

agatctgctg ctggcgccgc tgctctggca ctgacagtgg atctgcctcc tgccagcagc      360

gaggcccgga atagcgcatt tgggtttcaa ggcaggctgc tgcacctgtc tgccggccag      420

aggctgggag tgcatctgca cacagaggcc agggctagac acgcctggca gctgacacag      480

ggcgctacag tgctgggcct gttcagagtg acccccgaga ttccagccgg actgggaggc      540

ggaggttccg gaggcggagg atctgctagc acaaagggcc ccagcgtgtt ccctctggcc      600

cctagcagca agagcacatc tggcggaaca gccgccctgg gctgcctggt ggaagattac      660

ttccccgagc ccgtgaccgt gtcctggaat tctggcgccc tgacaagcgg cgtgcacacc      720

tttccagccg tgctgcagag cagcggcctg tactctctga gcagcgtcgt gacagtgccc      780

agcagctctc tgggcaccca gacctacatc tgcaacgtga accacaagcc cagcaacacc      840

aaggtggacg agaaggtgga acccaagtcc tgc                                   873


<210>  116
<211>  710
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Dimeric ligand (71-248) - CL* Fc knob chain

<400>  116

Arg Glu Gly Pro Glu Leu Ser Pro Asp Asp Pro Ala Gly Leu Leu Asp 
1               5                   10                  15      


Leu Arg Gln Gly Met Phe Ala Gln Leu Val Ala Gln Asn Val Leu Leu 
            20                  25                  30          


Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala Gly Val 
        35                  40                  45              


Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu Asp Thr Lys Glu Leu Val 
    50                  55                  60                  


Val Ala Lys Ala Gly Val Tyr Tyr Val Phe Phe Gln Leu Glu Leu Arg 
65                  70                  75                  80  


Arg Val Val Ala Gly Glu Gly Ser Gly Ser Val Ser Leu Ala Leu His 
                85                  90                  95      


Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala Leu Thr 
            100                 105                 110         


Val Asp Leu Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala Phe Gly 
        115                 120                 125             


Phe Gln Gly Arg Leu Leu His Leu Ser Ala Gly Gln Arg Leu Gly Val 
    130                 135                 140                 


His Leu His Thr Glu Ala Arg Ala Arg His Ala Trp Gln Leu Thr Gln 
145                 150                 155                 160 


Gly Ala Thr Val Leu Gly Leu Phe Arg Val Thr Pro Glu Ile Pro Ala 
                165                 170                 175     


Gly Leu Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Arg Glu Gly Pro 
            180                 185                 190         


Glu Leu Ser Pro Asp Asp Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly 
        195                 200                 205             


Met Phe Ala Gln Leu Val Ala Gln Asn Val Leu Leu Ile Asp Gly Pro 
    210                 215                 220                 


Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala Gly Val Ser Leu Thr Gly 
225                 230                 235                 240 


Gly Leu Ser Tyr Lys Glu Asp Thr Lys Glu Leu Val Val Ala Lys Ala 
                245                 250                 255     


Gly Val Tyr Tyr Val Phe Phe Gln Leu Glu Leu Arg Arg Val Val Ala 
            260                 265                 270         


Gly Glu Gly Ser Gly Ser Val Ser Leu Ala Leu His Leu Gln Pro Leu 
        275                 280                 285             


Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala Leu Thr Val Asp Leu Pro 
    290                 295                 300                 


Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg 
305                 310                 315                 320 


Leu Leu His Leu Ser Ala Gly Gln Arg Leu Gly Val His Leu His Thr 
                325                 330                 335     


Glu Ala Arg Ala Arg His Ala Trp Gln Leu Thr Gln Gly Ala Thr Val 
            340                 345                 350         


Leu Gly Leu Phe Arg Val Thr Pro Glu Ile Pro Ala Gly Leu Gly Gly 
        355                 360                 365             


Gly Gly Ser Gly Gly Gly Gly Ser Arg Thr Val Ala Ala Pro Ser Val 
    370                 375                 380                 


Phe Ile Phe Pro Pro Ser Asp Arg Lys Leu Lys Ser Gly Thr Ala Ser 
385                 390                 395                 400 


Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln 
                405                 410                 415     


Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val 
            420                 425                 430         


Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu 
        435                 440                 445             


Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu 
    450                 455                 460                 


Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg 
465                 470                 475                 480 


Gly Glu Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
                485                 490                 495     


Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
            500                 505                 510         


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
        515                 520                 525             


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
    530                 535                 540                 


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
545                 550                 555                 560 


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
                565                 570                 575     


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Gly 
            580                 585                 590         


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
        595                 600                 605             


Pro Gln Val Tyr Thr Leu Pro Pro Cys Arg Asp Glu Leu Thr Lys Asn 
    610                 615                 620                 


Gln Val Ser Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
625                 630                 635                 640 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
                645                 650                 655     


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
            660                 665                 670         


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
        675                 680                 685             


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
    690                 695                 700                 


Ser Leu Ser Pro Gly Lys 
705                 710 


<210>  117
<211>  291
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Monomeric ligand (71-248)-CH1*

<400>  117

Arg Glu Gly Pro Glu Leu Ser Pro Asp Asp Pro Ala Gly Leu Leu Asp 
1               5                   10                  15      


Leu Arg Gln Gly Met Phe Ala Gln Leu Val Ala Gln Asn Val Leu Leu 
            20                  25                  30          


Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala Gly Val 
        35                  40                  45              


Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu Asp Thr Lys Glu Leu Val 
    50                  55                  60                  


Val Ala Lys Ala Gly Val Tyr Tyr Val Phe Phe Gln Leu Glu Leu Arg 
65                  70                  75                  80  


Arg Val Val Ala Gly Glu Gly Ser Gly Ser Val Ser Leu Ala Leu His 
                85                  90                  95      


Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala Leu Thr 
            100                 105                 110         


Val Asp Leu Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala Phe Gly 
        115                 120                 125             


Phe Gln Gly Arg Leu Leu His Leu Ser Ala Gly Gln Arg Leu Gly Val 
    130                 135                 140                 


His Leu His Thr Glu Ala Arg Ala Arg His Ala Trp Gln Leu Thr Gln 
145                 150                 155                 160 


Gly Ala Thr Val Leu Gly Leu Phe Arg Val Thr Pro Glu Ile Pro Ala 
                165                 170                 175     


Gly Leu Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Ser Thr Lys 
            180                 185                 190         


Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly 
        195                 200                 205             


Gly Thr Ala Ala Leu Gly Cys Leu Val Glu Asp Tyr Phe Pro Glu Pro 
    210                 215                 220                 


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
225                 230                 235                 240 


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
                245                 250                 255     


Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn 
            260                 265                 270         


Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Glu Lys Val Glu Pro 
        275                 280                 285             


Lys Ser Cys 
    290     


<210>  118
<211>  2130
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Dimeric ligand (71-248) - CL Fc knob chain

<400>  118
agagagggcc ctgagctgag ccccgatgat cctgctggac tgctggacct gcggcagggc       60

atgtttgctc agctggtggc ccagaacgtg ctgctgatcg atggccccct gtcctggtac      120

agcgatcctg gactggctgg cgtgtcactg acaggcggcc tgagctacaa agaggacacc      180

aaagaactgg tggtggccaa ggccggcgtg tactacgtgt tctttcagct ggaactgcgg      240

agagtggtgg ccggcgaagg atctggctct gtgtctctgg ccctgcatct gcagcctctg      300

agatctgctg ctggcgccgc tgctctggca ctgacagtgg atctgcctcc tgccagcagc      360

gaggcccgga atagcgcatt tgggtttcaa ggcaggctgc tgcacctgtc tgccggccag      420

aggctgggag tgcatctgca cacagaggcc agggctagac acgcctggca gctgacacag      480

ggcgctacag tgctgggcct gttcagagtg acccccgaga ttccagccgg actgggaggc      540

ggcggatctg gcggcggagg atctagagaa ggacccgagc tgtcccctga cgatccagcc      600

gggctgctgg atctgagaca gggaatgttc gcccagctgg tggctcagaa tgtgctgctg      660

attgacggac ctctgagctg gtactccgac ccagggctgg caggggtgtc cctgactggg      720

ggactgtcct acaaagaaga tacaaaagaa ctggtggtgg ctaaagctgg ggtgtactat      780

gtgttttttc agctggaact gaggcgggtg gtggctgggg agggctcagg atctgtgtcc      840

ctggctctgc atctgcagcc actgcgctct gcagcagggg ctgcagcact ggccctgact      900

gtggacctgc ccccagcttc ttccgaggcc agaaacagcg ccttcgggtt ccaaggacgc      960

ctgctgcatc tgagcgccgg acagcgcctg ggagtgcatc tgcatactga agccagagcc     1020

cggcatgctt ggcagctgac tcagggggca actgtgctgg gactgtttcg cgtgacacct     1080

gagatccccg ctggactggg cggaggcggt tccggagggg gaggatctcg tacggtggcc     1140

gctccctccg tgtttatctt tcccccatcc gatgaacagc tgaaaagcgg caccgcctcc     1200

gtcgtgtgtc tgctgaacaa tttttaccct agggaagcta aagtgcagtg gaaagtggat     1260

aacgcactgc agtccggcaa ctcccaggaa tctgtgacag aacaggactc caaggacagc     1320

acctactccc tgtcctccac cctgacactg tctaaggctg attatgagaa acacaaagtc     1380

tacgcctgcg aagtcaccca tcagggcctg agctcgcccg tcacaaagag cttcaacagg     1440

ggagagtgtg acaagaccca cacctgtccc ccttgtcctg cccctgaagc tgctggcggc     1500

ccttctgtgt tcctgttccc cccaaagccc aaggacaccc tgatgatcag ccggaccccc     1560

gaagtgacct gcgtggtggt ggatgtgtcc cacgaggacc ctgaagtgaa gttcaattgg     1620

tacgtggacg gcgtggaagt gcacaatgcc aagaccaagc cgcgggagga gcagtacaac     1680

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag     1740

gagtacaagt gcaaggtctc caacaaagcc ctcggcgccc ccatcgagaa aaccatctcc     1800

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatg ccgggatgag     1860

ctgaccaaga accaggtcag cctgtggtgc ctggtcaaag gcttctatcc cagcgacatc     1920

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg     1980

ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg     2040

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg     2100

cagaagagcc tctccctgtc tccgggtaaa                                      2130


<210>  119
<211>  873
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Monomeric ligand (71-248)-CH1

<400>  119
agagagggcc ctgagctgag ccccgatgat cctgctggac tgctggacct gcggcagggc       60

atgtttgctc agctggtggc ccagaacgtg ctgctgatcg atggccccct gtcctggtac      120

agcgatcctg gactggctgg cgtgtcactg acaggcggcc tgagctacaa agaggacacc      180

aaagaactgg tggtggccaa ggccggcgtg tactacgtgt tctttcagct ggaactgcgg      240

agagtggtgg ccggcgaagg atctggctct gtgtctctgg ccctgcatct gcagcctctg      300

agatctgctg ctggcgccgc tgctctggca ctgacagtgg atctgcctcc tgccagcagc      360

gaggcccgga atagcgcatt tgggtttcaa ggcaggctgc tgcacctgtc tgccggccag      420

aggctgggag tgcatctgca cacagaggcc agggctagac acgcctggca gctgacacag      480

ggcgctacag tgctgggcct gttcagagtg acccccgaga ttccagccgg actgggaggc      540

ggaggttccg gaggcggagg atctgctagc accaaaggcc cttccgtgtt tcctctggct      600

cctagctcca agtccacctc tggaggcacc gctgctctcg gatgcctcgt gaaggattat      660

tttcctgagc ctgtgacagt gtcctggaat agcggagcac tgacctctgg agtgcatact      720

ttccccgctg tgctgcagtc ctctggactg tacagcctga gcagcgtggt gacagtgccc      780

agcagcagcc tgggcaccca gacctacatc tgcaacgtga accacaagcc cagcaacacc      840

aaggtggaca agaaggtgga acccaagtct tgt                                   873


<210>  120
<211>  710
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Dimeric ligand (71-248) - CL Fc knob chain

<400>  120

Arg Glu Gly Pro Glu Leu Ser Pro Asp Asp Pro Ala Gly Leu Leu Asp 
1               5                   10                  15      


Leu Arg Gln Gly Met Phe Ala Gln Leu Val Ala Gln Asn Val Leu Leu 
            20                  25                  30          


Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala Gly Val 
        35                  40                  45              


Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu Asp Thr Lys Glu Leu Val 
    50                  55                  60                  


Val Ala Lys Ala Gly Val Tyr Tyr Val Phe Phe Gln Leu Glu Leu Arg 
65                  70                  75                  80  


Arg Val Val Ala Gly Glu Gly Ser Gly Ser Val Ser Leu Ala Leu His 
                85                  90                  95      


Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala Leu Thr 
            100                 105                 110         


Val Asp Leu Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala Phe Gly 
        115                 120                 125             


Phe Gln Gly Arg Leu Leu His Leu Ser Ala Gly Gln Arg Leu Gly Val 
    130                 135                 140                 


His Leu His Thr Glu Ala Arg Ala Arg His Ala Trp Gln Leu Thr Gln 
145                 150                 155                 160 


Gly Ala Thr Val Leu Gly Leu Phe Arg Val Thr Pro Glu Ile Pro Ala 
                165                 170                 175     


Gly Leu Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Arg Glu Gly Pro 
            180                 185                 190         


Glu Leu Ser Pro Asp Asp Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly 
        195                 200                 205             


Met Phe Ala Gln Leu Val Ala Gln Asn Val Leu Leu Ile Asp Gly Pro 
    210                 215                 220                 


Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala Gly Val Ser Leu Thr Gly 
225                 230                 235                 240 


Gly Leu Ser Tyr Lys Glu Asp Thr Lys Glu Leu Val Val Ala Lys Ala 
                245                 250                 255     


Gly Val Tyr Tyr Val Phe Phe Gln Leu Glu Leu Arg Arg Val Val Ala 
            260                 265                 270         


Gly Glu Gly Ser Gly Ser Val Ser Leu Ala Leu His Leu Gln Pro Leu 
        275                 280                 285             


Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala Leu Thr Val Asp Leu Pro 
    290                 295                 300                 


Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg 
305                 310                 315                 320 


Leu Leu His Leu Ser Ala Gly Gln Arg Leu Gly Val His Leu His Thr 
                325                 330                 335     


Glu Ala Arg Ala Arg His Ala Trp Gln Leu Thr Gln Gly Ala Thr Val 
            340                 345                 350         


Leu Gly Leu Phe Arg Val Thr Pro Glu Ile Pro Ala Gly Leu Gly Gly 
        355                 360                 365             


Gly Gly Ser Gly Gly Gly Gly Ser Arg Thr Val Ala Ala Pro Ser Val 
    370                 375                 380                 


Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser 
385                 390                 395                 400 


Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln 
                405                 410                 415     


Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val 
            420                 425                 430         


Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu 
        435                 440                 445             


Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu 
    450                 455                 460                 


Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg 
465                 470                 475                 480 


Gly Glu Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
                485                 490                 495     


Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
            500                 505                 510         


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
        515                 520                 525             


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
    530                 535                 540                 


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
545                 550                 555                 560 


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
                565                 570                 575     


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Gly 
            580                 585                 590         


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
        595                 600                 605             


Pro Gln Val Tyr Thr Leu Pro Pro Cys Arg Asp Glu Leu Thr Lys Asn 
    610                 615                 620                 


Gln Val Ser Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
625                 630                 635                 640 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
                645                 650                 655     


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
            660                 665                 670         


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
        675                 680                 685             


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
    690                 695                 700                 


Ser Leu Ser Pro Gly Lys 
705                 710 


<210>  121
<211>  291
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Monomeric ligand (71-248)-CH1

<400>  121

Arg Glu Gly Pro Glu Leu Ser Pro Asp Asp Pro Ala Gly Leu Leu Asp 
1               5                   10                  15      


Leu Arg Gln Gly Met Phe Ala Gln Leu Val Ala Gln Asn Val Leu Leu 
            20                  25                  30          


Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala Gly Val 
        35                  40                  45              


Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu Asp Thr Lys Glu Leu Val 
    50                  55                  60                  


Val Ala Lys Ala Gly Val Tyr Tyr Val Phe Phe Gln Leu Glu Leu Arg 
65                  70                  75                  80  


Arg Val Val Ala Gly Glu Gly Ser Gly Ser Val Ser Leu Ala Leu His 
                85                  90                  95      


Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala Leu Thr 
            100                 105                 110         


Val Asp Leu Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala Phe Gly 
        115                 120                 125             


Phe Gln Gly Arg Leu Leu His Leu Ser Ala Gly Gln Arg Leu Gly Val 
    130                 135                 140                 


His Leu His Thr Glu Ala Arg Ala Arg His Ala Trp Gln Leu Thr Gln 
145                 150                 155                 160 


Gly Ala Thr Val Leu Gly Leu Phe Arg Val Thr Pro Glu Ile Pro Ala 
                165                 170                 175     


Gly Leu Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Ser Thr Lys 
            180                 185                 190         


Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly 
        195                 200                 205             


Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
    210                 215                 220                 


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
225                 230                 235                 240 


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
                245                 250                 255     


Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn 
            260                 265                 270         


Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro 
        275                 280                 285             


Lys Ser Cys 
    290     


<210>  122
<211>  2469
<212>  DNA
<213>  Artificial sequence

<220>
<223>  anti-TnC(18D4) Fc hole dimeric ligand (71-248) chain

<400>  122
caggtgcaat tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cctccggagg cacattcagc agctacgcta taagctgggt gcgacaggcc      120

cctggacaag ggctcgagtg gatgggaggg atcatcccta tctttggtac agcaaactac      180

gcacagaagt tccagggcag ggtcaccatt actgcagaca aatccacgag cacagcctac      240

atggagctga gcagcctgag atctgaggac accgccgtgt attactgtgc gaaaggtaac      300

ttctacggtg gtctggacta ctggggccaa gggaccaccg tgaccgtctc ctcagctagc      360

accaagggcc cctccgtgtt ccccctggcc cccagcagca agagcaccag cggcggcaca      420

gccgctctgg gctgcctggt caaggactac ttccccgagc ccgtgaccgt gtcctggaac      480

agcggagccc tgacctccgg cgtgcacacc ttccccgccg tgctgcagag ttctggcctg      540

tatagcctga gcagcgtggt caccgtgcct tctagcagcc tgggcaccca gacctacatc      600

tgcaacgtga accacaagcc cagcaacacc aaggtggaca agaaggtgga gcccaagagc      660

tgcgacaaaa ctcacacatg cccaccgtgc ccagcacctg aagctgcagg gggaccgtca      720

gtcttcctct tccccccaaa acccaaggac accctcatga tctcccggac ccctgaggtc      780

acatgcgtgg tggtggacgt gagccacgaa gaccctgagg tcaagttcaa ctggtacgtg      840

gacggcgtgg aggtgcataa tgccaagaca aagccgcggg aggagcagta caacagcacg      900

taccgtgtgg tcagcgtcct caccgtcctg caccaggact ggctgaatgg caaggagtac      960

aagtgcaagg tctccaacaa agccctcggc gcccccatcg agaaaaccat ctccaaagcc     1020

aaagggcagc cccgagaacc acaggtgtgc accctgcccc catcccggga tgagctgacc     1080

aagaaccagg tcagcctctc gtgcgcagtc aaaggcttct atcccagcga catcgccgtg     1140

gagtgggaga gcaatgggca gccggagaac aactacaaga ccacgcctcc cgtgctggac     1200

tccgacggct ccttcttcct cgtgagcaag ctcaccgtgg acaagagcag gtggcagcag     1260

gggaacgtct tctcatgctc cgtgatgcat gaggctctgc acaaccacta cacgcagaag     1320

agcctctccc tgtctccggg tggaggcggc ggaagcggag gaggaggatc cagagagggc     1380

cctgagctga gccctgatga tcctgccgga ctgctggacc tgcggcaggg aatgtttgcc     1440

cagctggtgg cccagaacgt gctgctgatc gatggccccc tgtcctggta cagcgatcct     1500

ggactggctg gcgtgtcact gacaggcggc ctgagctaca aagaggacac caaagaactg     1560

gtggtggcca aggccggcgt gtactacgtg ttctttcagc tggaactgcg gagagtggtg     1620

gccggcgaag gatctggctc tgtgtctctg gccctgcatc tgcagcctct gagatctgct     1680

gctggcgccg ctgctctggc actgacagtg gatctgcctc ctgccagcag cgaggcccgg     1740

aatagcgcat ttgggtttca aggcaggctg ctgcacctgt ctgccggcca gaggctggga     1800

gtgcatctgc acacagaggc cagggctaga cacgcctggc agctgacaca gggcgctaca     1860

gtgctgggcc tgttcagagt gacccccgag attccagcag gcctgggagg cggcggatct     1920

ggcggcggag gatctagaga aggacccgag ctgtcccccg acgatcccgc tgggctgctg     1980

gatctgagac agggcatgtt cgctcagctg gtggctcaga atgtgctgct gattgacgga     2040

cctctgagct ggtactccga cccagggctg gcaggggtgt ccctgactgg gggactgtcc     2100

tacaaagaag atacaaaaga actggtggtg gctaaagctg gggtgtacta tgtgtttttt     2160

cagctggaac tgaggcgggt ggtggctggg gagggctcag gatctgtgtc cctggctctg     2220

catctgcagc cactgcgctc tgcagcaggg gctgcagcac tggccctgac tgtggacctg     2280

cccccagctt cttccgaggc cagaaacagc gccttcgggt tccaaggacg cctgctgcat     2340

ctgagcgccg gacagcgcct gggagtgcat ctgcatactg aagccagagc ccggcatgct     2400

tggcagctga ctcagggggc aactgtgctg ggactgtttc gcgtgacacc tgagatccca     2460

gccgggctc                                                             2469


<210>  123
<211>  1905
<212>  DNA
<213>  Artificial sequence

<220>
<223>  anti-TnC(18D4) Fc knob monomeric (71-248) ligand

<400>  123
caggtgcaat tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cctccggagg cacattcagc agctacgcta taagctgggt gcgacaggcc      120

cctggacaag ggctcgagtg gatgggaggg atcatcccta tctttggtac agcaaactac      180

gcacagaagt tccagggcag ggtcaccatt actgcagaca aatccacgag cacagcctac      240

atggagctga gcagcctgag atctgaggac accgccgtgt attactgtgc gaaaggtaac      300

ttctacggtg gtctggacta ctggggccaa gggaccaccg tgaccgtctc ctcagctagc      360

accaagggcc catcggtctt ccccctggca ccctcctcca agagcacctc tgggggcaca      420

gcggccctgg gctgcctggt caaggactac ttccccgaac cggtgacggt gtcgtggaac      480

tcaggcgccc tgaccagcgg cgtgcacacc ttcccggctg tcctacagtc ctcaggactc      540

tactccctca gcagcgtggt gaccgtgccc tccagcagct tgggcaccca gacctacatc      600

tgcaacgtga atcacaagcc cagcaacacc aaggtggaca agaaagttga gcccaaatct      660

tgtgacaaaa ctcacacatg cccaccgtgc ccagcacctg aagctgcagg gggaccgtca      720

gtcttcctct tccccccaaa acccaaggac accctcatga tctcccggac ccctgaggtc      780

acatgcgtgg tggtggacgt gagccacgaa gaccctgagg tcaagttcaa ctggtacgtg      840

gacggcgtgg aggtgcataa tgccaagaca aagccgcggg aggagcagta caacagcacg      900

taccgtgtgg tcagcgtcct caccgtcctg caccaggact ggctgaatgg caaggagtac      960

aagtgcaagg tctccaacaa agccctcggc gcccccatcg agaaaaccat ctccaaagcc     1020

aaagggcagc cccgagaacc acaggtgtac accctgcccc cctgcagaga tgagctgacc     1080

aagaaccagg tgtccctgtg gtgtctggtc aagggcttct accccagcga tatcgccgtg     1140

gagtgggaga gcaacggcca gcctgagaac aactacaaga ccaccccccc tgtgctggac     1200

agcgacggca gcttcttcct gtactccaaa ctgaccgtgg acaagagccg gtggcagcag     1260

ggcaacgtgt tcagctgcag cgtgatgcac gaggccctgc acaaccacta cacccagaag     1320

tccctgagcc tgagccccgg cggaggcggc ggaagcggag gaggaggatc cagagagggc     1380

cctgagctga gccctgatga tcctgccgga ctgctggacc tgcggcaggg aatgtttgcc     1440

cagctggtgg cccagaacgt gctgctgatc gatggccccc tgtcctggta cagcgatcct     1500

ggactggctg gcgtgtcact gacaggcggc ctgagctaca aagaggacac caaagaactg     1560

gtggtggcca aggccggcgt gtactacgtg ttctttcagc tggaactgcg gagagtggtg     1620

gccggcgaag gatctggctc tgtgtctctg gccctgcatc tgcagcctct gagatctgct     1680

gctggcgccg ctgctctggc actgacagtg gatctgcctc ctgccagcag cgaggcccgg     1740

aatagcgcat ttgggtttca aggcaggctg ctgcacctgt ctgccggcca gaggctggga     1800

gtgcatctgc acacagaggc cagggctaga cacgcctggc agctgacaca gggcgctaca     1860

gtgctgggcc tgttcagagt gacccccgag attcctgccg ggctc                     1905


<210>  124
<211>  823
<212>  PRT
<213>  Artificial sequence

<220>
<223>  anti-TnC(18D4) Fc hole dimeric ligand (71-248) chain

<400>  124

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Asn Phe Tyr Gly Gly Leu Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr 
    210                 215                 220                 


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser 
225                 230                 235                 240 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                245                 250                 255     


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
            260                 265                 270         


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        275                 280                 285             


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
    290                 295                 300                 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
305                 310                 315                 320 


Lys Cys Lys Val Ser Asn Lys Ala Leu Gly Ala Pro Ile Glu Lys Thr 
                325                 330                 335     


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Cys Thr Leu 
            340                 345                 350         


Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Ser Cys 
        355                 360                 365             


Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    370                 375                 380                 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
385                 390                 395                 400 


Ser Asp Gly Ser Phe Phe Leu Val Ser Lys Leu Thr Val Asp Lys Ser 
                405                 410                 415     


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            420                 425                 430         


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Gly 
        435                 440                 445             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Arg Glu Gly Pro Glu Leu Ser 
    450                 455                 460                 


Pro Asp Asp Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala 
465                 470                 475                 480 


Gln Leu Val Ala Gln Asn Val Leu Leu Ile Asp Gly Pro Leu Ser Trp 
                485                 490                 495     


Tyr Ser Asp Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser 
            500                 505                 510         


Tyr Lys Glu Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr 
        515                 520                 525             


Tyr Val Phe Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly 
    530                 535                 540                 


Ser Gly Ser Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala 
545                 550                 555                 560 


Ala Gly Ala Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser 
                565                 570                 575     


Ser Glu Ala Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His 
            580                 585                 590         


Leu Ser Ala Gly Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg 
        595                 600                 605             


Ala Arg His Ala Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu 
    610                 615                 620                 


Phe Arg Val Thr Pro Glu Ile Pro Ala Gly Leu Gly Gly Gly Gly Ser 
625                 630                 635                 640 


Gly Gly Gly Gly Ser Arg Glu Gly Pro Glu Leu Ser Pro Asp Asp Pro 
                645                 650                 655     


Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu Val Ala 
            660                 665                 670         


Gln Asn Val Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp Pro 
        675                 680                 685             


Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu Asp 
    690                 695                 700                 


Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe Phe 
705                 710                 715                 720 


Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser Val 
                725                 730                 735     


Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala Ala 
            740                 745                 750         


Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala Arg 
        755                 760                 765             


Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala Gly 
    770                 775                 780                 


Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg His Ala 
785                 790                 795                 800 


Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val Thr 
                805                 810                 815     


Pro Glu Ile Pro Ala Gly Leu 
            820             


<210>  125
<211>  635
<212>  PRT
<213>  Artificial sequence

<220>
<223>  anti- TnC(18D4) Fc knob monomeric (71-248) ligand

<400>  125

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Asn Phe Tyr Gly Gly Leu Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr 
    210                 215                 220                 


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser 
225                 230                 235                 240 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                245                 250                 255     


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
            260                 265                 270         


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        275                 280                 285             


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
    290                 295                 300                 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
305                 310                 315                 320 


Lys Cys Lys Val Ser Asn Lys Ala Leu Gly Ala Pro Ile Glu Lys Thr 
                325                 330                 335     


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            340                 345                 350         


Pro Pro Cys Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Trp Cys 
        355                 360                 365             


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    370                 375                 380                 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
385                 390                 395                 400 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
                405                 410                 415     


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            420                 425                 430         


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Gly 
        435                 440                 445             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Arg Glu Gly Pro Glu Leu Ser 
    450                 455                 460                 


Pro Asp Asp Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala 
465                 470                 475                 480 


Gln Leu Val Ala Gln Asn Val Leu Leu Ile Asp Gly Pro Leu Ser Trp 
                485                 490                 495     


Tyr Ser Asp Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser 
            500                 505                 510         


Tyr Lys Glu Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr 
        515                 520                 525             


Tyr Val Phe Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly 
    530                 535                 540                 


Ser Gly Ser Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala 
545                 550                 555                 560 


Ala Gly Ala Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser 
                565                 570                 575     


Ser Glu Ala Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His 
            580                 585                 590         


Leu Ser Ala Gly Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg 
        595                 600                 605             


Ala Arg His Ala Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu 
    610                 615                 620                 


Phe Arg Val Thr Pro Glu Ile Pro Ala Gly Leu 
625                 630                 635 


<210>  126
<211>  1806
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Fc hole dimeric ligand (71-248) chain

<400>  126
gacaaaactc acacatgccc accgtgccca gcacctgaag ctgcaggggg accgtcagtc       60

ttcctcttcc ccccaaaacc caaggacacc ctcatgatct cccggacccc tgaggtcaca      120

tgcgtggtgg tggacgtgag ccacgaagac cctgaggtca agttcaactg gtacgtggac      180

ggcgtggagg tgcataatgc caagacaaag ccgcgggagg agcagtacaa cagcacgtac      240

cgtgtggtca gcgtcctcac cgtcctgcac caggactggc tgaatggcaa ggagtacaag      300

tgcaaggtct ccaacaaagc cctcggcgcc cccatcgaga aaaccatctc caaagccaaa      360

gggcagcccc gagaaccaca ggtgtgcacc ctgcccccat cccgggatga gctgaccaag      420

aaccaggtca gcctctcgtg cgcagtcaaa ggcttctatc ccagcgacat cgccgtggag      480

tgggagagca atgggcagcc ggagaacaac tacaagacca cgcctcccgt gctggactcc      540

gacggctcct tcttcctcgt gagcaagctc accgtggaca agagcaggtg gcagcagggg      600

aacgtcttct catgctccgt gatgcatgag gctctgcaca accactacac gcagaagagc      660

ctctccctgt ctccgggtgg aggcggcgga agcggaggag gaggatccag agagggccct      720

gagctgagcc ctgatgatcc tgccggactg ctggacctgc ggcagggaat gtttgcccag      780

ctggtggccc agaacgtgct gctgatcgat ggccccctgt cctggtacag cgatcctgga      840

ctggctggcg tgtcactgac aggcggcctg agctacaaag aggacaccaa agaactggtg      900

gtggccaagg ccggcgtgta ctacgtgttc tttcagctgg aactgcggag agtggtggcc      960

ggcgaaggat ctggctctgt gtctctggcc ctgcatctgc agcctctgag atctgctgct     1020

ggcgccgctg ctctggcact gacagtggat ctgcctcctg ccagcagcga ggcccggaat     1080

agcgcatttg ggtttcaagg caggctgctg cacctgtctg ccggccagag gctgggagtg     1140

catctgcaca cagaggccag ggctagacac gcctggcagc tgacacaggg cgctacagtg     1200

ctgggcctgt tcagagtgac ccccgagatt ccagcaggcc tgggaggcgg cggatctggc     1260

ggcggaggat ctagagaagg acccgagctg tcccccgacg atcccgctgg gctgctggat     1320

ctgagacagg gcatgttcgc tcagctggtg gctcagaatg tgctgctgat tgacggacct     1380

ctgagctggt actccgaccc agggctggca ggggtgtccc tgactggggg actgtcctac     1440

aaagaagata caaaagaact ggtggtggct aaagctgggg tgtactatgt gttttttcag     1500

ctggaactga ggcgggtggt ggctggggag ggctcaggat ctgtgtccct ggctctgcat     1560

ctgcagccac tgcgctctgc agcaggggct gcagcactgg ccctgactgt ggacctgccc     1620

ccagcttctt ccgaggccag aaacagcgcc ttcgggttcc aaggacgcct gctgcatctg     1680

agcgccggac agcgcctggg agtgcatctg catactgaag ccagagcccg gcatgcttgg     1740

cagctgactc agggggcaac tgtgctggga ctgtttcgcg tgacacctga gatcccagcc     1800

gggctc                                                                1806


<210>  127
<211>  602
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Fc hole dimeric ligand (71-248) chain

<400>  127

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Gly Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Cys Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Val Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Arg Glu Gly Pro 
225                 230                 235                 240 


Glu Leu Ser Pro Asp Asp Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly 
                245                 250                 255     


Met Phe Ala Gln Leu Val Ala Gln Asn Val Leu Leu Ile Asp Gly Pro 
            260                 265                 270         


Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala Gly Val Ser Leu Thr Gly 
        275                 280                 285             


Gly Leu Ser Tyr Lys Glu Asp Thr Lys Glu Leu Val Val Ala Lys Ala 
    290                 295                 300                 


Gly Val Tyr Tyr Val Phe Phe Gln Leu Glu Leu Arg Arg Val Val Ala 
305                 310                 315                 320 


Gly Glu Gly Ser Gly Ser Val Ser Leu Ala Leu His Leu Gln Pro Leu 
                325                 330                 335     


Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala Leu Thr Val Asp Leu Pro 
            340                 345                 350         


Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg 
        355                 360                 365             


Leu Leu His Leu Ser Ala Gly Gln Arg Leu Gly Val His Leu His Thr 
    370                 375                 380                 


Glu Ala Arg Ala Arg His Ala Trp Gln Leu Thr Gln Gly Ala Thr Val 
385                 390                 395                 400 


Leu Gly Leu Phe Arg Val Thr Pro Glu Ile Pro Ala Gly Leu Gly Gly 
                405                 410                 415     


Gly Gly Ser Gly Gly Gly Gly Ser Arg Glu Gly Pro Glu Leu Ser Pro 
            420                 425                 430         


Asp Asp Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln 
        435                 440                 445             


Leu Val Ala Gln Asn Val Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr 
    450                 455                 460                 


Ser Asp Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr 
465                 470                 475                 480 


Lys Glu Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr 
                485                 490                 495     


Val Phe Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser 
            500                 505                 510         


Gly Ser Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala 
        515                 520                 525             


Gly Ala Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser 
    530                 535                 540                 


Glu Ala Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu 
545                 550                 555                 560 


Ser Ala Gly Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala 
                565                 570                 575     


Arg His Ala Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe 
            580                 585                 590         


Arg Val Thr Pro Glu Ile Pro Ala Gly Leu 
        595                 600         


<210>  128
<211>  1212
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Fc hole monomeric ligand (71-248) chain

<400>  128
gacaaaactc acacatgccc accgtgccca gcacctgaag ctgcaggggg accgtcagtc       60

ttcctcttcc ccccaaaacc caaggacacc ctcatgatct cccggacccc tgaggtcaca      120

tgcgtggtgg tggacgtgag ccacgaagac cctgaggtca agttcaactg gtacgtggac      180

ggcgtggagg tgcataatgc caagacaaag ccgcgggagg agcagtacaa cagcacgtac      240

cgtgtggtca gcgtcctcac cgtcctgcac caggactggc tgaatggcaa ggagtacaag      300

tgcaaggtct ccaacaaagc cctcggcgcc cccatcgaga aaaccatctc caaagccaaa      360

gggcagcccc gagaaccaca ggtgtgcacc ctgcccccat cccgggatga gctgaccaag      420

aaccaggtca gcctctcgtg cgcagtcaaa ggcttctatc ccagcgacat cgccgtggag      480

tgggagagca atgggcagcc ggagaacaac tacaagacca cgcctcccgt gctggactcc      540

gacggctcct tcttcctcgt gagcaagctc accgtggaca agagcaggtg gcagcagggg      600

aacgtcttct catgctccgt gatgcatgag gctctgcaca accactacac gcagaagagc      660

ctctccctgt ctccgggtag agagggccct gagctgagcc ctgatgatcc tgccggactg      720

ctggacctgc ggcagggaat gtttgcccag ctggtggccc agaacgtgct gctgatcgat      780

ggccccctgt cctggtacag cgatcctgga ctggctggcg tgtcactgac aggcggcctg      840

agctacaaag aggacaccaa agaactggtg gtggccaagg ccggcgtgta ctacgtgttc      900

tttcagctgg aactgcggag agtggtggcc ggcgaaggat ctggctctgt gtctctggcc      960

ctgcatctgc agcctctgag atctgctgct ggcgccgctg ctctggcact gacagtggat     1020

ctgcctcctg ccagcagcga ggcccggaat agcgcatttg ggtttcaagg caggctgctg     1080

cacctgtctg ccggccagag gctgggagtg catctgcaca cagaggccag ggctagacac     1140

gcctggcagc tgacacaggg cgctacagtg ctgggcctgt tcagagtgac ccccgagatt     1200

cctgccgggc tc                                                         1212


<210>  129
<211>  2439
<212>  DNA
<213>  Artificial sequence

<220>
<223>  anti-TnC(18D4) Fc knob dimeric ligand (71-248) chain

<400>  129
caggtgcaat tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cctccggagg cacattcagc agctacgcta taagctgggt gcgacaggcc      120

cctggacaag ggctcgagtg gatgggaggg atcatcccta tctttggtac agcaaactac      180

gcacagaagt tccagggcag ggtcaccatt actgcagaca aatccacgag cacagcctac      240

atggagctga gcagcctgag atctgaggac accgccgtgt attactgtgc gaaaggtaac      300

ttctacggtg gtctggacta ctggggccaa gggaccaccg tgaccgtctc ctcagctagc      360

accaagggcc catcggtctt ccccctggca ccctcctcca agagcacctc tgggggcaca      420

gcggccctgg gctgcctggt caaggactac ttccccgaac cggtgacggt gtcgtggaac      480

tcaggcgccc tgaccagcgg cgtgcacacc ttcccggctg tcctacagtc ctcaggactc      540

tactccctca gcagcgtggt gaccgtgccc tccagcagct tgggcaccca gacctacatc      600

tgcaacgtga atcacaagcc cagcaacacc aaggtggaca agaaagttga gcccaaatct      660

tgtgacaaaa ctcacacatg cccaccgtgc ccagcacctg aagctgcagg gggaccgtca      720

gtcttcctct tccccccaaa acccaaggac accctcatga tctcccggac ccctgaggtc      780

acatgcgtgg tggtggacgt gagccacgaa gaccctgagg tcaagttcaa ctggtacgtg      840

gacggcgtgg aggtgcataa tgccaagaca aagccgcggg aggagcagta caacagcacg      900

taccgtgtgg tcagcgtcct caccgtcctg caccaggact ggctgaatgg caaggagtac      960

aagtgcaagg tctccaacaa agccctcggc gcccccatcg agaaaaccat ctccaaagcc     1020

aaagggcagc cccgagaacc acaggtgtac accctgcccc cctgcagaga tgagctgacc     1080

aagaaccagg tgtccctgtg gtgtctggtc aagggcttct accccagcga tatcgccgtg     1140

gagtgggaga gcaacggcca gcctgagaac aactacaaga ccaccccccc tgtgctggac     1200

agcgacggca gcttcttcct gtactccaaa ctgaccgtgg acaagagccg gtggcagcag     1260

ggcaacgtgt tcagctgcag cgtgatgcac gaggccctgc acaaccacta cacccagaag     1320

tccctgagcc tgagccccgg cagagagggc cctgagctga gccctgatga tcctgccgga     1380

ctgctggacc tgcggcaggg aatgtttgcc cagctggtgg cccagaacgt gctgctgatc     1440

gatggccccc tgtcctggta cagcgatcct ggactggctg gcgtgtcact gacaggcggc     1500

ctgagctaca aagaggacac caaagaactg gtggtggcca aggccggcgt gtactacgtg     1560

ttctttcagc tggaactgcg gagagtggtg gccggcgaag gatctggctc tgtgtctctg     1620

gccctgcatc tgcagcctct gagatctgct gctggcgccg ctgctctggc actgacagtg     1680

gatctgcctc ctgccagcag cgaggcccgg aatagcgcat ttgggtttca aggcaggctg     1740

ctgcacctgt ctgccggcca gaggctggga gtgcatctgc acacagaggc cagggctaga     1800

cacgcctggc agctgacaca gggcgctaca gtgctgggcc tgttcagagt gacccccgag     1860

attccagcag gcctgggagg cggcggatct ggcggcggag gatctagaga aggacccgag     1920

ctgtcccccg acgatcccgc tgggctgctg gatctgagac agggcatgtt cgctcagctg     1980

gtggctcaga atgtgctgct gattgacgga cctctgagct ggtactccga cccagggctg     2040

gcaggggtgt ccctgactgg gggactgtcc tacaaagaag atacaaaaga actggtggtg     2100

gctaaagctg gggtgtacta tgtgtttttt cagctggaac tgaggcgggt ggtggctggg     2160

gagggctcag gatctgtgtc cctggctctg catctgcagc cactgcgctc tgcagcaggg     2220

gctgcagcac tggccctgac tgtggacctg cccccagctt cttccgaggc cagaaacagc     2280

gccttcgggt tccaaggacg cctgctgcat ctgagcgccg gacagcgcct gggagtgcat     2340

ctgcatactg aagccagagc ccggcatgct tggcagctga ctcagggggc aactgtgctg     2400

ggactgtttc gcgtgacacc tgagatccca gccgggctc                            2439


<210>  130
<211>  404
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Fc hole monomeric ligand (71-248) chain

<400>  130

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Gly Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Cys Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Val Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Arg Glu Gly Pro Glu Leu Ser Pro Asp Asp Pro Ala Gly Leu 
225                 230                 235                 240 


Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu Val Ala Gln Asn Val 
                245                 250                 255     


Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala 
            260                 265                 270         


Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu Asp Thr Lys Glu 
        275                 280                 285             


Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe Phe Gln Leu Glu 
    290                 295                 300                 


Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser Val Ser Leu Ala 
305                 310                 315                 320 


Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala 
                325                 330                 335     


Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala 
            340                 345                 350         


Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala Gly Gln Arg Leu 
        355                 360                 365             


Gly Val His Leu His Thr Glu Ala Arg Ala Arg His Ala Trp Gln Leu 
    370                 375                 380                 


Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val Thr Pro Glu Ile 
385                 390                 395                 400 


Pro Ala Gly Leu 
                


<210>  131
<211>  813
<212>  PRT
<213>  Artificial sequence

<220>
<223>  anti-TnC(18D4) Fc knob dimeric ligand (71-248) chain

<400>  131

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Asn Phe Tyr Gly Gly Leu Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr 
    210                 215                 220                 


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser 
225                 230                 235                 240 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                245                 250                 255     


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
            260                 265                 270         


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        275                 280                 285             


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
    290                 295                 300                 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
305                 310                 315                 320 


Lys Cys Lys Val Ser Asn Lys Ala Leu Gly Ala Pro Ile Glu Lys Thr 
                325                 330                 335     


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            340                 345                 350         


Pro Pro Cys Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Trp Cys 
        355                 360                 365             


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    370                 375                 380                 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
385                 390                 395                 400 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
                405                 410                 415     


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            420                 425                 430         


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Arg 
        435                 440                 445             


Glu Gly Pro Glu Leu Ser Pro Asp Asp Pro Ala Gly Leu Leu Asp Leu 
    450                 455                 460                 


Arg Gln Gly Met Phe Ala Gln Leu Val Ala Gln Asn Val Leu Leu Ile 
465                 470                 475                 480 


Asp Gly Pro Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala Gly Val Ser 
                485                 490                 495     


Leu Thr Gly Gly Leu Ser Tyr Lys Glu Asp Thr Lys Glu Leu Val Val 
            500                 505                 510         


Ala Lys Ala Gly Val Tyr Tyr Val Phe Phe Gln Leu Glu Leu Arg Arg 
        515                 520                 525             


Val Val Ala Gly Glu Gly Ser Gly Ser Val Ser Leu Ala Leu His Leu 
    530                 535                 540                 


Gln Pro Leu Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala Leu Thr Val 
545                 550                 555                 560 


Asp Leu Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala Phe Gly Phe 
                565                 570                 575     


Gln Gly Arg Leu Leu His Leu Ser Ala Gly Gln Arg Leu Gly Val His 
            580                 585                 590         


Leu His Thr Glu Ala Arg Ala Arg His Ala Trp Gln Leu Thr Gln Gly 
        595                 600                 605             


Ala Thr Val Leu Gly Leu Phe Arg Val Thr Pro Glu Ile Pro Ala Gly 
    610                 615                 620                 


Leu Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Arg Glu Gly Pro Glu 
625                 630                 635                 640 


Leu Ser Pro Asp Asp Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met 
                645                 650                 655     


Phe Ala Gln Leu Val Ala Gln Asn Val Leu Leu Ile Asp Gly Pro Leu 
            660                 665                 670         


Ser Trp Tyr Ser Asp Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly 
        675                 680                 685             


Leu Ser Tyr Lys Glu Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly 
    690                 695                 700                 


Val Tyr Tyr Val Phe Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly 
705                 710                 715                 720 


Glu Gly Ser Gly Ser Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg 
                725                 730                 735     


Ser Ala Ala Gly Ala Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro 
            740                 745                 750         


Ala Ser Ser Glu Ala Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu 
        755                 760                 765             


Leu His Leu Ser Ala Gly Gln Arg Leu Gly Val His Leu His Thr Glu 
    770                 775                 780                 


Ala Arg Ala Arg His Ala Trp Gln Leu Thr Gln Gly Ala Thr Val Leu 
785                 790                 795                 800 


Gly Leu Phe Arg Val Thr Pro Glu Ile Pro Ala Gly Leu 
                805                 810             


<210>  132
<211>  1242
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Fc knob monomeric ligand (71-248) chain

<400>  132
gacaaaactc acacatgccc accgtgccca gcacctgaag ctgcaggggg accgtcagtc       60

ttcctcttcc ccccaaaacc caaggacacc ctcatgatct cccggacccc tgaggtcaca      120

tgcgtggtgg tggacgtgag ccacgaagac cctgaggtca agttcaactg gtacgtggac      180

ggcgtggagg tgcataatgc caagacaaag ccgcgggagg agcagtacaa cagcacgtac      240

cgtgtggtca gcgtcctcac cgtcctgcac caggactggc tgaatggcaa ggagtacaag      300

tgcaaggtct ccaacaaagc cctcggcgcc cccatcgaga aaaccatctc caaagccaaa      360

gggcagcccc gagaaccaca ggtgtacacc ctgcccccct gcagagatga gctgaccaag      420

aaccaggtgt ccctgtggtg tctggtcaag ggcttctacc ccagcgatat cgccgtggag      480

tgggagagca acggccagcc tgagaacaac tacaagacca ccccccctgt gctggacagc      540

gacggcagct tcttcctgta ctccaaactg accgtggaca agagccggtg gcagcagggc      600

aacgtgttca gctgcagcgt gatgcacgag gccctgcaca accactacac ccagaagtcc      660

ctgagcctga gccccggcgg aggcggcgga agcggaggag gaggatccag agagggccct      720

gagctgagcc ctgatgatcc tgccggactg ctggacctgc ggcagggaat gtttgcccag      780

ctggtggccc agaacgtgct gctgatcgat ggccccctgt cctggtacag cgatcctgga      840

ctggctggcg tgtcactgac aggcggcctg agctacaaag aggacaccaa agaactggtg      900

gtggccaagg ccggcgtgta ctacgtgttc tttcagctgg aactgcggag agtggtggcc      960

ggcgaaggat ctggctctgt gtctctggcc ctgcatctgc agcctctgag atctgctgct     1020

ggcgccgctg ctctggcact gacagtggat ctgcctcctg ccagcagcga ggcccggaat     1080

agcgcatttg ggtttcaagg caggctgctg cacctgtctg ccggccagag gctgggagtg     1140

catctgcaca cagaggccag ggctagacac gcctggcagc tgacacaggg cgctacagtg     1200

ctgggcctgt tcagagtgac ccccgagatt cctgccgggc tc                        1242


<210>  133
<211>  414
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Fc knob monomeric ligand (71-248) chain

<400>  133

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Gly Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Cys Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Arg Glu Gly Pro 
225                 230                 235                 240 


Glu Leu Ser Pro Asp Asp Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly 
                245                 250                 255     


Met Phe Ala Gln Leu Val Ala Gln Asn Val Leu Leu Ile Asp Gly Pro 
            260                 265                 270         


Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala Gly Val Ser Leu Thr Gly 
        275                 280                 285             


Gly Leu Ser Tyr Lys Glu Asp Thr Lys Glu Leu Val Val Ala Lys Ala 
    290                 295                 300                 


Gly Val Tyr Tyr Val Phe Phe Gln Leu Glu Leu Arg Arg Val Val Ala 
305                 310                 315                 320 


Gly Glu Gly Ser Gly Ser Val Ser Leu Ala Leu His Leu Gln Pro Leu 
                325                 330                 335     


Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala Leu Thr Val Asp Leu Pro 
            340                 345                 350         


Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg 
        355                 360                 365             


Leu Leu His Leu Ser Ala Gly Gln Arg Leu Gly Val His Leu His Thr 
    370                 375                 380                 


Glu Ala Arg Ala Arg His Ala Trp Gln Leu Thr Gln Gly Ala Thr Val 
385                 390                 395                 400 


Leu Gly Leu Phe Arg Val Thr Pro Glu Ile Pro Ala Gly Leu 
                405                 410                 


<210>  134
<211>  1905
<212>  DNA
<213>  Artificial sequence

<220>
<223>  anti-TnC(18D4) Fc hole monomeric ligand (71-248)  chain

<400>  134
caggtgcaat tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cctccggagg cacattcagc agctacgcta taagctgggt gcgacaggcc      120

cctggacaag ggctcgagtg gatgggaggg atcatcccta tctttggtac agcaaactac      180

gcacagaagt tccagggcag ggtcaccatt actgcagaca aatccacgag cacagcctac      240

atggagctga gcagcctgag atctgaggac accgccgtgt attactgtgc gaaaggtaac      300

ttctacggtg gtctggacta ctggggccaa gggaccaccg tgaccgtctc ctcagctagc      360

accaagggcc cctccgtgtt ccccctggcc cccagcagca agagcaccag cggcggcaca      420

gccgctctgg gctgcctggt caaggactac ttccccgagc ccgtgaccgt gtcctggaac      480

agcggagccc tgacctccgg cgtgcacacc ttccccgccg tgctgcagag ttctggcctg      540

tatagcctga gcagcgtggt caccgtgcct tctagcagcc tgggcaccca gacctacatc      600

tgcaacgtga accacaagcc cagcaacacc aaggtggaca agaaggtgga gcccaagagc      660

tgcgacaaaa ctcacacatg cccaccgtgc ccagcacctg aagctgcagg gggaccgtca      720

gtcttcctct tccccccaaa acccaaggac accctcatga tctcccggac ccctgaggtc      780

acatgcgtgg tggtggacgt gagccacgaa gaccctgagg tcaagttcaa ctggtacgtg      840

gacggcgtgg aggtgcataa tgccaagaca aagccgcggg aggagcagta caacagcacg      900

taccgtgtgg tcagcgtcct caccgtcctg caccaggact ggctgaatgg caaggagtac      960

aagtgcaagg tctccaacaa agccctcggc gcccccatcg agaaaaccat ctccaaagcc     1020

aaagggcagc cccgagaacc acaggtgtgc accctgcccc catcccggga tgagctgacc     1080

aagaaccagg tcagcctctc gtgcgcagtc aaaggcttct atcccagcga catcgccgtg     1140

gagtgggaga gcaatgggca gccggagaac aactacaaga ccacgcctcc cgtgctggac     1200

tccgacggct ccttcttcct cgtgagcaag ctcaccgtgg acaagagcag gtggcagcag     1260

gggaacgtct tctcatgctc cgtgatgcat gaggctctgc acaaccacta cacgcagaag     1320

agcctctccc tgtctccggg tggaggcggc ggaagcggag gaggaggatc cagagagggc     1380

cctgagctga gccctgatga tcctgccgga ctgctggacc tgcggcaggg aatgtttgcc     1440

cagctggtgg cccagaacgt gctgctgatc gatggccccc tgtcctggta cagcgatcct     1500

ggactggctg gcgtgtcact gacaggcggc ctgagctaca aagaggacac caaagaactg     1560

gtggtggcca aggccggcgt gtactacgtg ttctttcagc tggaactgcg gagagtggtg     1620

gccggcgaag gatctggctc tgtgtctctg gccctgcatc tgcagcctct gagatctgct     1680

gctggcgccg ctgctctggc actgacagtg gatctgcctc ctgccagcag cgaggcccgg     1740

aatagcgcat ttgggtttca aggcaggctg ctgcacctgt ctgccggcca gaggctggga     1800

gtgcatctgc acacagaggc cagggctaga cacgcctggc agctgacaca gggcgctaca     1860

gtgctgggcc tgttcagagt gacccccgag attcctgccg ggctc                     1905


<210>  135
<211>  1806
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Fc knob dimeric ligand (71-248) chain

<400>  135
gacaaaactc acacatgccc accgtgccca gcacctgaag ctgcaggggg accgtcagtc       60

ttcctcttcc ccccaaaacc caaggacacc ctcatgatct cccggacccc tgaggtcaca      120

tgcgtggtgg tggacgtgag ccacgaagac cctgaggtca agttcaactg gtacgtggac      180

ggcgtggagg tgcataatgc caagacaaag ccgcgggagg agcagtacaa cagcacgtac      240

cgtgtggtca gcgtcctcac cgtcctgcac caggactggc tgaatggcaa ggagtacaag      300

tgcaaggtct ccaacaaagc cctcggcgcc cccatcgaga aaaccatctc caaagccaaa      360

gggcagcccc gagaaccaca ggtgtacacc ctgcccccct gcagagatga gctgaccaag      420

aaccaggtgt ccctgtggtg tctggtcaag ggcttctacc ccagcgatat cgccgtggag      480

tgggagagca acggccagcc tgagaacaac tacaagacca ccccccctgt gctggacagc      540

gacggcagct tcttcctgta ctccaaactg accgtggaca agagccggtg gcagcagggc      600

aacgtgttca gctgcagcgt gatgcacgag gccctgcaca accactacac ccagaagtcc      660

ctgagcctga gccccggcgg aggcggcgga agcggaggag gaggatccag agagggccct      720

gagctgagcc ctgatgatcc tgccggactg ctggacctgc ggcagggaat gtttgcccag      780

ctggtggccc agaacgtgct gctgatcgat ggccccctgt cctggtacag cgatcctgga      840

ctggctggcg tgtcactgac aggcggcctg agctacaaag aggacaccaa agaactggtg      900

gtggccaagg ccggcgtgta ctacgtgttc tttcagctgg aactgcggag agtggtggcc      960

ggcgaaggat ctggctctgt gtctctggcc ctgcatctgc agcctctgag atctgctgct     1020

ggcgccgctg ctctggcact gacagtggat ctgcctcctg ccagcagcga ggcccggaat     1080

agcgcatttg ggtttcaagg caggctgctg cacctgtctg ccggccagag gctgggagtg     1140

catctgcaca cagaggccag ggctagacac gcctggcagc tgacacaggg cgctacagtg     1200

ctgggcctgt tcagagtgac ccccgagatt ccagcaggcc tgggaggcgg cggatctggc     1260

ggcggaggat ctagagaagg acccgagctg tcccccgacg atcccgctgg gctgctggat     1320

ctgagacagg gcatgttcgc tcagctggtg gctcagaatg tgctgctgat tgacggacct     1380

ctgagctggt actccgaccc agggctggca ggggtgtccc tgactggggg actgtcctac     1440

aaagaagata caaaagaact ggtggtggct aaagctgggg tgtactatgt gttttttcag     1500

ctggaactga ggcgggtggt ggctggggag ggctcaggat ctgtgtccct ggctctgcat     1560

ctgcagccac tgcgctctgc agcaggggct gcagcactgg ccctgactgt ggacctgccc     1620

ccagcttctt ccgaggccag aaacagcgcc ttcgggttcc aaggacgcct gctgcatctg     1680

agcgccggac agcgcctggg agtgcatctg catactgaag ccagagcccg gcatgcttgg     1740

cagctgactc agggggcaac tgtgctggga ctgtttcgcg tgacacctga gatcccagcc     1800

gggctc                                                                1806


<210>  136
<211>  635
<212>  PRT
<213>  Artificial sequence

<220>
<223>  anti-TnC(18D4) Fc hole monomeric ligand (71-248) chain

<400>  136

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Asn Phe Tyr Gly Gly Leu Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr 
    210                 215                 220                 


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser 
225                 230                 235                 240 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                245                 250                 255     


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
            260                 265                 270         


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        275                 280                 285             


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
    290                 295                 300                 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
305                 310                 315                 320 


Lys Cys Lys Val Ser Asn Lys Ala Leu Gly Ala Pro Ile Glu Lys Thr 
                325                 330                 335     


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Cys Thr Leu 
            340                 345                 350         


Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Ser Cys 
        355                 360                 365             


Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    370                 375                 380                 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
385                 390                 395                 400 


Ser Asp Gly Ser Phe Phe Leu Val Ser Lys Leu Thr Val Asp Lys Ser 
                405                 410                 415     


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            420                 425                 430         


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Gly 
        435                 440                 445             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Arg Glu Gly Pro Glu Leu Ser 
    450                 455                 460                 


Pro Asp Asp Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala 
465                 470                 475                 480 


Gln Leu Val Ala Gln Asn Val Leu Leu Ile Asp Gly Pro Leu Ser Trp 
                485                 490                 495     


Tyr Ser Asp Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser 
            500                 505                 510         


Tyr Lys Glu Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr 
        515                 520                 525             


Tyr Val Phe Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly 
    530                 535                 540                 


Ser Gly Ser Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala 
545                 550                 555                 560 


Ala Gly Ala Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser 
                565                 570                 575     


Ser Glu Ala Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His 
            580                 585                 590         


Leu Ser Ala Gly Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg 
        595                 600                 605             


Ala Arg His Ala Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu 
    610                 615                 620                 


Phe Arg Val Thr Pro Glu Ile Pro Ala Gly Leu 
625                 630                 635 


<210>  137
<211>  602
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Fc knob dimeric ligand (71-248) chain

<400>  137

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Gly Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Cys Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Arg Glu Gly Pro 
225                 230                 235                 240 


Glu Leu Ser Pro Asp Asp Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly 
                245                 250                 255     


Met Phe Ala Gln Leu Val Ala Gln Asn Val Leu Leu Ile Asp Gly Pro 
            260                 265                 270         


Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala Gly Val Ser Leu Thr Gly 
        275                 280                 285             


Gly Leu Ser Tyr Lys Glu Asp Thr Lys Glu Leu Val Val Ala Lys Ala 
    290                 295                 300                 


Gly Val Tyr Tyr Val Phe Phe Gln Leu Glu Leu Arg Arg Val Val Ala 
305                 310                 315                 320 


Gly Glu Gly Ser Gly Ser Val Ser Leu Ala Leu His Leu Gln Pro Leu 
                325                 330                 335     


Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala Leu Thr Val Asp Leu Pro 
            340                 345                 350         


Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg 
        355                 360                 365             


Leu Leu His Leu Ser Ala Gly Gln Arg Leu Gly Val His Leu His Thr 
    370                 375                 380                 


Glu Ala Arg Ala Arg His Ala Trp Gln Leu Thr Gln Gly Ala Thr Val 
385                 390                 395                 400 


Leu Gly Leu Phe Arg Val Thr Pro Glu Ile Pro Ala Gly Leu Gly Gly 
                405                 410                 415     


Gly Gly Ser Gly Gly Gly Gly Ser Arg Glu Gly Pro Glu Leu Ser Pro 
            420                 425                 430         


Asp Asp Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln 
        435                 440                 445             


Leu Val Ala Gln Asn Val Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr 
    450                 455                 460                 


Ser Asp Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr 
465                 470                 475                 480 


Lys Glu Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr 
                485                 490                 495     


Val Phe Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser 
            500                 505                 510         


Gly Ser Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala 
        515                 520                 525             


Gly Ala Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser 
    530                 535                 540                 


Glu Ala Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu 
545                 550                 555                 560 


Ser Ala Gly Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala 
                565                 570                 575     


Arg His Ala Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe 
            580                 585                 590         


Arg Val Thr Pro Glu Ile Pro Ala Gly Leu 
        595                 600         


<210>  138
<211>  1335
<212>  DNA
<213>  Artificial sequence

<220>
<223>  DP47 Fc hole chain

<400>  138
gaggtgcaat tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctccggatt cacctttagc agttatgcca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcagct attagtggta gtggtggtag cacatactac      180

gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcagatga acagcctgag agccgaggac acggccgtat attactgtgc gaaaggcagc      300

ggatttgact actggggcca aggaaccctg gtcaccgtct cgagtgctag caccaagggc      360

ccatcggtct tccccctggc accctcctcc aagagcacct ctgggggcac agcggccctg      420

ggctgcctgg tcaaggacta cttccccgaa ccggtgacgg tgtcgtggaa ctcaggcgcc      480

ctgaccagcg gcgtgcacac cttcccggct gtcctacagt cctcaggact ctactccctc      540

agcagcgtgg tgaccgtgcc ctccagcagc ttgggcaccc agacctacat ctgcaacgtg      600

aatcacaagc ccagcaacac caaggtggac aagaaagttg agcccaaatc ttgtgacaaa      660

actcacacat gcccaccgtg cccagcacct gaagctgcag ggggaccgtc agtcttcctc      720

ttccccccaa aacccaagga caccctcatg atctcccgga cccctgaggt cacatgcgtg      780

gtggtggacg tgagccacga agaccctgag gtcaagttca actggtacgt ggacggcgtg      840

gaggtgcata atgccaagac aaagccgcgg gaggagcagt acaacagcac gtaccgtgtg      900

gtcagcgtcc tcaccgtcct gcaccaggac tggctgaatg gcaaggagta caagtgcaag      960

gtctccaaca aagccctcgg cgcccccatc gagaaaacca tctccaaagc caaagggcag     1020

ccccgagaac cacaggtgtg caccctgccc ccatcccggg atgagctgac caagaaccag     1080

gtcagcctct cgtgcgcagt caaaggcttc tatcccagcg acatcgccgt ggagtgggag     1140

agcaatgggc agccggagaa caactacaag accacgcctc ccgtgctgga ctccgacggc     1200

tccttcttcc tcgtgagcaa gctcaccgtg gacaagagca ggtggcagca ggggaacgtc     1260

ttctcatgct ccgtgatgca tgaggctctg cacaaccact acacgcagaa gagcctctcc     1320

ctgtctccgg gtaaa                                                      1335


<210>  139
<211>  645
<212>  DNA
<213>  Artificial sequence

<220>
<223>  DP47 light chain

<400>  139
gaaatcgtgt taacgcagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc       60

ctctcttgca gggccagtca gagtgttagc agcagctact tagcctggta ccagcagaaa      120

cctggccagg ctcccaggct cctcatctat ggagcatcca gcagggccac tggcatccca      180

gacaggttca gtggcagtgg atccgggaca gacttcactc tcaccatcag cagactggag      240

cctgaagatt ttgcagtgta ttactgtcag cagtatggta gctcaccgct gacgttcggc      300

caggggacca aagtggaaat caaacgtacg gtggctgcac catctgtctt catcttcccg      360

ccatctgatg agcagttgaa atctggaact gcctctgttg tgtgcctgct gaataacttc      420

tatcccagag aggccaaagt acagtggaag gtggataacg ccctccaatc gggtaactcc      480

caggagagtg tcacagagca ggacagcaag gacagcacct acagcctcag cagcaccctg      540

acgctgagca aagcagacta cgagaaacac aaagtctacg cctgcgaagt cacccatcag      600

ggcctgagct cgcccgtcac aaagagcttc aacaggggag agtgt                      645


<210>  140
<211>  445
<212>  PRT
<213>  Artificial sequence

<220>
<223>  DP47 Fc hole chain

<400>  140

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Ser Gly Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro 
        115                 120                 125             


Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val 
    130                 135                 140                 


Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala 
145                 150                 155                 160 


Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly 
                165                 170                 175     


Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly 
            180                 185                 190         


Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys 
        195                 200                 205             


Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys 
    210                 215                 220                 


Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu 
225                 230                 235                 240 


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
                245                 250                 255     


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
            260                 265                 270         


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        275                 280                 285             


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
    290                 295                 300                 


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
305                 310                 315                 320 


Val Ser Asn Lys Ala Leu Gly Ala Pro Ile Glu Lys Thr Ile Ser Lys 
                325                 330                 335     


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Cys Thr Leu Pro Pro Ser 
            340                 345                 350         


Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Ser Cys Ala Val Lys 
        355                 360                 365             


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    370                 375                 380                 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
385                 390                 395                 400 


Ser Phe Phe Leu Val Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
                405                 410                 415     


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            420                 425                 430         


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445 


<210>  141
<211>  215
<212>  PRT
<213>  Artificial sequence

<220>
<223>  DP47 light chain

<400>  141

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 
                85                  90                  95      


Leu Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala 
            100                 105                 110         


Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
        115                 120                 125             


Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
    130                 135                 140                 


Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
145                 150                 155                 160 


Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
                165                 170                 175     


Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
            180                 185                 190         


Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
        195                 200                 205             


Ser Phe Asn Arg Gly Glu Cys 
    210                 215 


<210>  142
<211>  2496
<212>  DNA
<213>  Artificial sequence

<220>
<223>  DP47 Fc hole chain fused to dimeric hu 4-1BBL (71-254)

<400>  142
gaggtgcaat tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctccggatt cacctttagc agttatgcca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcagct attagtggta gtggtggtag cacatactac      180

gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcagatga acagcctgag agccgaggac acggccgtat attactgtgc gaaaggcagc      300

ggatttgact actggggcca aggaaccctg gtcaccgtct cgagtgctag caccaagggc      360

ccctccgtgt tccccctggc ccccagcagc aagagcacca gcggcggcac agccgctctg      420

ggctgcctgg tcaaggacta cttccccgag cccgtgaccg tgtcctggaa cagcggagcc      480

ctgacctccg gcgtgcacac cttccccgcc gtgctgcaga gttctggcct gtatagcctg      540

agcagcgtgg tcaccgtgcc ttctagcagc ctgggcaccc agacctacat ctgcaacgtg      600

aaccacaagc ccagcaacac caaggtggac aagaaggtgg agcccaagag ctgcgacaaa      660

actcacacat gcccaccgtg cccagcacct gaagctgcag ggggaccgtc agtcttcctc      720

ttccccccaa aacccaagga caccctcatg atctcccgga cccctgaggt cacatgcgtg      780

gtggtggacg tgagccacga agaccctgag gtcaagttca actggtacgt ggacggcgtg      840

gaggtgcata atgccaagac aaagccgcgg gaggagcagt acaacagcac gtaccgtgtg      900

gtcagcgtcc tcaccgtcct gcaccaggac tggctgaatg gcaaggagta caagtgcaag      960

gtctccaaca aagccctcgg cgcccccatc gagaaaacca tctccaaagc caaagggcag     1020

ccccgagaac cacaggtgtg caccctgccc ccatcccggg atgagctgac caagaaccag     1080

gtcagcctct cgtgcgcagt caaaggcttc tatcccagcg acatcgccgt ggagtgggag     1140

agcaatgggc agccggagaa caactacaag accacgcctc ccgtgctgga ctccgacggc     1200

tccttcttcc tcgtgagcaa gctcaccgtg gacaagagca ggtggcagca ggggaacgtc     1260

ttctcatgct ccgtgatgca tgaggctctg cacaaccact acacgcagaa gagcctctcc     1320

ctgtctccgg gtggaggcgg cggaagcgga ggaggaggat ccagagaggg ccctgagctg     1380

agccccgatg atcctgctgg actgctggac ctgcggcagg gcatgtttgc tcagctggtg     1440

gcccagaacg tgctgctgat cgatggcccc ctgtcctggt acagcgatcc tggactggct     1500

ggcgtgtcac tgacaggcgg cctgagctac aaagaggaca ccaaagaact ggtggtggcc     1560

aaggccggcg tgtactacgt gttctttcag ctggaactgc ggagagtggt ggccggcgaa     1620

ggatctggct ctgtgtctct ggccctgcat ctgcagcctc tgagaagcgc tgctggcgct     1680

gcagctctgg cactgacagt ggatctgcct cctgccagct ccgaggcccg gaatagcgca     1740

tttgggtttc aaggcaggct gctgcacctg tctgccggcc agaggctggg agtgcatctg     1800

cacacagagg ccagggctag acacgcctgg cagctgacac agggcgctac agtgctgggc     1860

ctgttcagag tgacccccga gattccagcc ggcctgcctt ctccaagaag cgaaggcgga     1920

ggcggatctg gcggcggagg atctagagag ggacccgaac tgtcccctga cgatccagcc     1980

gggctgctgg atctgagaca gggaatgttc gcccagctgg tggctcagaa tgtgctgctg     2040

attgacggac ctctgagctg gtactccgac ccagggctgg caggggtgtc cctgactggg     2100

ggactgtcct acaaagaaga tacaaaagaa ctggtggtgg ctaaagctgg ggtgtactat     2160

gtgttttttc agctggaact gaggcgggtg gtggctgggg agggctcagg atctgtgtcc     2220

ctggctctgc atctgcagcc actgcgctct gctgctggcg cagctgcact ggctctgact     2280

gtggacctgc caccagcctc tagcgaggcc agaaacagcg ccttcgggtt ccaaggacgc     2340

ctgctgcatc tgagcgccgg acagcgcctg ggagtgcatc tgcatactga agccagagcc     2400

cggcatgctt ggcagctgac tcagggggca actgtgctgg gactgtttcg cgtgacacct     2460

gagatccctg ccggactgcc aagccctaga tcagaa                               2496


<210>  143
<211>  1914
<212>  DNA
<213>  Artificial sequence

<220>
<223>  DP47 Fc knob chain fused to monomeric hu 4-1BBL (71-254)

<400>  143
gaggtgcaat tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctccggatt cacctttagc agttatgcca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcagct attagtggta gtggtggtag cacatactac      180

gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcagatga acagcctgag agccgaggac acggccgtat attactgtgc gaaaggcagc      300

ggatttgact actggggcca aggaaccctg gtcaccgtct cgagtgctag caccaagggc      360

ccatcggtct tccccctggc accctcctcc aagagcacct ctgggggcac agcggccctg      420

ggctgcctgg tcaaggacta cttccccgaa ccggtgacgg tgtcgtggaa ctcaggcgcc      480

ctgaccagcg gcgtgcacac cttcccggct gtcctacagt cctcaggact ctactccctc      540

agcagcgtgg tgaccgtgcc ctccagcagc ttgggcaccc agacctacat ctgcaacgtg      600

aatcacaagc ccagcaacac caaggtggac aagaaagttg agcccaaatc ttgtgacaaa      660

actcacacat gcccaccgtg cccagcacct gaagctgcag ggggaccgtc agtcttcctc      720

ttccccccaa aacccaagga caccctcatg atctcccgga cccctgaggt cacatgcgtg      780

gtggtggacg tgagccacga agaccctgag gtcaagttca actggtacgt ggacggcgtg      840

gaggtgcata atgccaagac aaagccgcgg gaggagcagt acaacagcac gtaccgtgtg      900

gtcagcgtcc tcaccgtcct gcaccaggac tggctgaatg gcaaggagta caagtgcaag      960

gtctccaaca aagccctcgg cgcccccatc gagaaaacca tctccaaagc caaagggcag     1020

ccccgagaac cacaggtgta caccctgccc ccctgcagag atgagctgac caagaaccag     1080

gtgtccctgt ggtgtctggt caagggcttc taccccagcg atatcgccgt ggagtgggag     1140

agcaacggcc agcctgagaa caactacaag accacccccc ctgtgctgga cagcgacggc     1200

agcttcttcc tgtactccaa actgaccgtg gacaagagcc ggtggcagca gggcaacgtg     1260

ttcagctgca gcgtgatgca cgaggccctg cacaaccact acacccagaa gtccctgagc     1320

ctgagccccg gcggaggcgg cggaagcgga ggaggaggat ccagagaggg ccctgagctg     1380

agccccgatg atcctgctgg actgctggac ctgcggcagg gcatgtttgc tcagctggtg     1440

gcccagaacg tgctgctgat cgatggcccc ctgtcctggt acagcgatcc tggactggct     1500

ggcgtgtcac tgacaggcgg cctgagctac aaagaggaca ccaaagaact ggtggtggcc     1560

aaggccggcg tgtactacgt gttctttcag ctggaactgc ggagagtggt ggccggcgaa     1620

ggatctggct ctgtgtctct ggccctgcat ctgcagcctc tgagaagcgc tgctggcgct     1680

gcagctctgg cactgacagt ggatctgcct cctgccagct ccgaggcccg gaatagcgca     1740

tttgggtttc aaggcaggct gctgcacctg tctgccggcc agaggctggg agtgcatctg     1800

cacacagagg ccagggctag acacgcctgg cagctgacac agggcgctac agtgctgggc     1860

ctgttcagag tgacccccga gattccagcc ggcctgcctt ctccaagaag cgaa           1914


<210>  144
<211>  832
<212>  PRT
<213>  Artificial sequence

<220>
<223>  DP47 Fc hole chain fused to dimeric hu 4-1BBL (71-254)

<400>  144

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Ser Gly Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro 
        115                 120                 125             


Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val 
    130                 135                 140                 


Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala 
145                 150                 155                 160 


Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly 
                165                 170                 175     


Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly 
            180                 185                 190         


Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys 
        195                 200                 205             


Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys 
    210                 215                 220                 


Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu 
225                 230                 235                 240 


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
                245                 250                 255     


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
            260                 265                 270         


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        275                 280                 285             


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
    290                 295                 300                 


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
305                 310                 315                 320 


Val Ser Asn Lys Ala Leu Gly Ala Pro Ile Glu Lys Thr Ile Ser Lys 
                325                 330                 335     


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Cys Thr Leu Pro Pro Ser 
            340                 345                 350         


Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Ser Cys Ala Val Lys 
        355                 360                 365             


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    370                 375                 380                 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
385                 390                 395                 400 


Ser Phe Phe Leu Val Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
                405                 410                 415     


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            420                 425                 430         


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Gly Gly Gly Gly 
        435                 440                 445             


Ser Gly Gly Gly Gly Ser Arg Glu Gly Pro Glu Leu Ser Pro Asp Asp 
    450                 455                 460                 


Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu Val 
465                 470                 475                 480 


Ala Gln Asn Val Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp 
                485                 490                 495     


Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu 
            500                 505                 510         


Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe 
        515                 520                 525             


Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser 
    530                 535                 540                 


Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala 
545                 550                 555                 560 


Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala 
                565                 570                 575     


Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala 
            580                 585                 590         


Gly Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg His 
        595                 600                 605             


Ala Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val 
    610                 615                 620                 


Thr Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu Gly Gly 
625                 630                 635                 640 


Gly Gly Ser Gly Gly Gly Gly Ser Arg Glu Gly Pro Glu Leu Ser Pro 
                645                 650                 655     


Asp Asp Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln 
            660                 665                 670         


Leu Val Ala Gln Asn Val Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr 
        675                 680                 685             


Ser Asp Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr 
    690                 695                 700                 


Lys Glu Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr 
705                 710                 715                 720 


Val Phe Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser 
                725                 730                 735     


Gly Ser Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala 
            740                 745                 750         


Gly Ala Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser 
        755                 760                 765             


Glu Ala Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu 
    770                 775                 780                 


Ser Ala Gly Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala 
785                 790                 795                 800 


Arg His Ala Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe 
                805                 810                 815     


Arg Val Thr Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu 
            820                 825                 830         


<210>  145
<211>  640
<212>  PRT
<213>  Artificial sequence

<220>
<223>  DP47 Fc knob chain fused to monomeric hu 4-1BBL (71-254)

<400>  145

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ile Gly Ser Gly Ala Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Trp Phe Gly Gly Phe Asn Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His 
    210                 215                 220                 


Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
            260                 265                 270         


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Ala Leu Gly Ala Pro Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Cys Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Trp Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Gly Gly 
        435                 440                 445             


Gly Gly Ser Gly Gly Gly Gly Ser Arg Glu Gly Pro Glu Leu Ser Pro 
    450                 455                 460                 


Asp Asp Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln 
465                 470                 475                 480 


Leu Val Ala Gln Asn Val Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr 
                485                 490                 495     


Ser Asp Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr 
            500                 505                 510         


Lys Glu Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr 
        515                 520                 525             


Val Phe Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser 
    530                 535                 540                 


Gly Ser Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala 
545                 550                 555                 560 


Gly Ala Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser 
                565                 570                 575     


Glu Ala Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu 
            580                 585                 590         


Ser Ala Gly Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala 
        595                 600                 605             


Arg His Ala Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe 
    610                 615                 620                 


Arg Val Thr Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu 
625                 630                 635                 640 


<210>  146
<211>  1335
<212>  DNA
<213>  Artificial sequence

<220>
<223>  DP47 heavy chain (hu IgG1 PGLALA)

<400>  146
gaggtgcaat tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctccggatt cacctttagc agttatgcca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcagct attagtggta gtggtggtag cacatactac      180

gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcagatga acagcctgag agccgaggac acggccgtat attactgtgc gaaaggcagc      300

ggatttgact actggggcca aggaaccctg gtcaccgtct cgagtgctag caccaagggc      360

ccatcggtct tccccctggc accctcctcc aagagcacct ctgggggcac agcggccctg      420

ggctgcctgg tcaaggacta cttccccgaa ccggtgacgg tgtcgtggaa ctcaggcgcc      480

ctgaccagcg gcgtgcacac cttcccggct gtcctacagt cctcaggact ctactccctc      540

agcagcgtgg tgaccgtgcc ctccagcagc ttgggcaccc agacctacat ctgcaacgtg      600

aatcacaagc ccagcaacac caaggtggac aagaaagttg agcccaaatc ttgtgacaaa      660

actcacacat gcccaccgtg cccagcacct gaagctgcag ggggaccgtc agtcttcctc      720

ttccccccaa aacccaagga caccctcatg atctcccgga cccctgaggt cacatgcgtg      780

gtggtggacg tgagccacga agaccctgag gtcaagttca actggtacgt ggacggcgtg      840

gaggtgcata atgccaagac aaagccgcgg gaggagcagt acaacagcac gtaccgtgtg      900

gtcagcgtcc tcaccgtcct gcaccaggac tggctgaatg gcaaggagta caagtgcaag      960

gtctccaaca aagccctcgg cgcccccatc gagaaaacca tctccaaagc caaagggcag     1020

ccccgagaac cacaggtgta caccctgccc ccatcccggg atgagctgac caagaaccag     1080

gtcagcctga cctgcctggt caaaggcttc tatcccagcg acatcgccgt ggagtgggag     1140

agcaatgggc agccggagaa caactacaag accacgcctc ccgtgctgga ctccgacggc     1200

tccttcttcc tctacagcaa gctcaccgtg gacaagagca ggtggcagca ggggaacgtc     1260

ttctcatgct ccgtgatgca tgaggctctg cacaaccact acacgcagaa gagcctctcc     1320

ctgtctccgg gtaaa                                                      1335


<210>  147
<211>  445
<212>  PRT
<213>  Artificial sequence

<220>
<223>  DP47 heavy chain (hu IgG1 PGLALA)

<400>  147

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Ser Gly Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro 
        115                 120                 125             


Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val 
    130                 135                 140                 


Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala 
145                 150                 155                 160 


Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly 
                165                 170                 175     


Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly 
            180                 185                 190         


Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys 
        195                 200                 205             


Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys 
    210                 215                 220                 


Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu 
225                 230                 235                 240 


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
                245                 250                 255     


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
            260                 265                 270         


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        275                 280                 285             


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
    290                 295                 300                 


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
305                 310                 315                 320 


Val Ser Asn Lys Ala Leu Gly Ala Pro Ile Glu Lys Thr Ile Ser Lys 
                325                 330                 335     


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
            340                 345                 350         


Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
        355                 360                 365             


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    370                 375                 380                 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
385                 390                 395                 400 


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
                405                 410                 415     


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            420                 425                 430         


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445 


<210>  148
<211>  1344
<212>  DNA
<213>  Artificial sequence

<220>
<223>  anti-TnC(18D4) heavy chain (huIgG1 PGLALA)

<400>  148
caggtgcaat tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cctccggagg cacattcagc agctacgcta taagctgggt gcgacaggcc      120

cctggacaag ggctcgagtg gatgggaggg atcatcccta tctttggtac agcaaactac      180

gcacagaagt tccagggcag ggtcaccatt actgcagaca aatccacgag cacagcctac      240

atggagctga gcagcctgag atctgaggac accgccgtgt attactgtgc gaaaggtaac      300

ttctacggtg gtctggacta ctggggccaa gggaccaccg tgaccgtctc ctcagctagc      360

accaagggcc catcggtctt ccccctggca ccctcctcca agagcacctc tgggggcaca      420

gcggccctgg gctgcctggt caaggactac ttccccgaac cggtgacggt gtcgtggaac      480

tcaggcgccc tgaccagcgg cgtgcacacc ttcccggctg tcctacagtc ctcaggactc      540

tactccctca gcagcgtggt gaccgtgccc tccagcagct tgggcaccca gacctacatc      600

tgcaacgtga atcacaagcc cagcaacacc aaggtggaca agaaagttga gcccaaatct      660

tgtgacaaaa ctcacacatg cccaccgtgc ccagcacctg aagctgcagg gggaccgtca      720

gtcttcctct tccccccaaa acccaaggac accctcatga tctcccggac ccctgaggtc      780

acatgcgtgg tggtggacgt gagccacgaa gaccctgagg tcaagttcaa ctggtacgtg      840

gacggcgtgg aggtgcataa tgccaagaca aagccgcggg aggagcagta caacagcacg      900

taccgtgtgg tcagcgtcct caccgtcctg caccaggact ggctgaatgg caaggagtac      960

aagtgcaagg tctccaacaa agccctcggc gcccccatcg agaaaaccat ctccaaagcc     1020

aaagggcagc cccgagaacc acaggtgtac accctgcccc catcccggga tgagctgacc     1080

aagaaccagg tcagcctgac ctgcctggtc aaaggcttct atcccagcga catcgccgtg     1140

gagtgggaga gcaatgggca gccggagaac aactacaaga ccacgcctcc cgtgctggac     1200

tccgacggct ccttcttcct ctacagcaag ctcaccgtgg acaagagcag gtggcagcag     1260

gggaacgtct tctcatgctc cgtgatgcat gaggctctgc acaaccacta cacgcagaag     1320

agcctctccc tgtctccggg taaa                                            1344


<210>  149
<211>  448
<212>  PRT
<213>  Artificial sequence

<220>
<223>  anti-TnC(18D4) heavy chain (huIgG1 PGLALA)

<400>  149

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Asn Phe Tyr Gly Gly Leu Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr 
    210                 215                 220                 


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser 
225                 230                 235                 240 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                245                 250                 255     


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
            260                 265                 270         


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        275                 280                 285             


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
    290                 295                 300                 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
305                 310                 315                 320 


Lys Cys Lys Val Ser Asn Lys Ala Leu Gly Ala Pro Ile Glu Lys Thr 
                325                 330                 335     


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            340                 345                 350         


Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys 
        355                 360                 365             


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    370                 375                 380                 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
385                 390                 395                 400 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
                405                 410                 415     


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            420                 425                 430         


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445             


<210>  150
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Peptide linker (G4S)2

<400>  150

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10  


<210>  151
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Peptide linker (SG4)2

<400>  151

Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
1               5                   10  


<210>  152
<211>  14
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Peptide linker G4(SG4)2

<400>  152

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
1               5                   10                  


<210>  153
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Peptide linker

<400>  153

Gly Ser Pro Gly Ser Ser Ser Ser Gly Ser 
1               5                   10  


<210>  154
<211>  20
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Peptide linker (G4S)4

<400>  154

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser 
            20  


<210>  155
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Peptide linker

<400>  155

Gly Ser Gly Ser Gly Asn Gly Ser 
1               5               


<210>  156
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Peptide linker

<400>  156

Gly Gly Ser Gly Ser Gly Ser Gly 
1               5               


<210>  157
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Peptide linker

<400>  157

Gly Gly Ser Gly Ser Gly 
1               5       


<210>  158
<211>  4
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Peptide linker

<400>  158

Gly Gly Ser Gly 
1               


<210>  159
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Peptide linker

<400>  159

Gly Gly Ser Gly Asn Gly Ser Gly 
1               5               


<210>  160
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Peptide linker

<400>  160

Gly Gly Asn Gly Ser Gly Ser Gly 
1               5               


<210>  161
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Peptide linker

<400>  161

Gly Gly Asn Gly Ser Gly 
1               5       


<210>  162
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Peptide linker

<400>  162

Gly Gly Gly Gly Ser 
1               5   


<210>  163
<211>  19
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Leader Sequence 1

<400>  163

Met Asp Trp Thr Trp Arg Ile Leu Phe Leu Val Ala Ala Ala Thr Gly 
1               5                   10                  15      


Ala His Ser 
            


<210>  164
<211>  57
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Leader Sequence 1 (DNA1)

<400>  164
atggactgga cctggagaat cctcttcttg gtggcagcag ccacaggagc ccactcc          57


<210>  165
<211>  57
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Leader Sequence 1 (DNA 2)

<400>  165
atggactgga cctggaggat cctcttcttg gtggcagcag ccacaggagc ccactcc          57


<210>  166
<211>  20
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Leader Sequence 2

<400>  166

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Phe Pro Gly Ala 
            20  


<210>  167
<211>  66
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Leader Sequence 2 (DNA)

<400>  167
atggacatga gggtccccgc tcagctcctg ggcctcctgc tgctctggtt cccaggtgcc       60

aggtgt                                                                  66


<210>  168
<211>  19
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Leader Sequence 3

<400>  168

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser 
            


<210>  169
<211>  57
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Leader Sequence 3 (DNA 1)

<400>  169
atgggatgga gctgtatcat cctcttcttg gtagcaacag ctaccggtgt gcattcg          57


<210>  170
<211>  57
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Leader Sequence 3 (DNA 2)

<400>  170
atgggctggt cctgcatcat cctgtttctg gtggctaccg ccactggagt gcattcc          57


<210>  171
<211>  57
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Leader Sequence 3 (DNA 3)

<400>  171
atgggctggt cctgcatcat cctgtttctg gtcgccacag ccaccggcgt gcactct          57


<210>  172
<211>  184
<212>  PRT
<213>  Homo sapiens

<400>  172

Arg Glu Gly Pro Glu Leu Ser Pro Asp Asp Pro Ala Gly Leu Leu Asp 
1               5                   10                  15      


Leu Arg Gln Gly Met Phe Ala Gln Leu Val Ala Gln Asn Val Leu Leu 
            20                  25                  30          


Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala Gly Val 
        35                  40                  45              


Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu Asp Thr Lys Glu Leu Val 
    50                  55                  60                  


Val Ala Lys Ala Gly Val Tyr Tyr Val Phe Phe Gln Leu Glu Leu Arg 
65                  70                  75                  80  


Arg Val Val Ala Gly Glu Gly Ser Gly Ser Val Ser Leu Ala Leu His 
                85                  90                  95      


Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala Leu Thr 
            100                 105                 110         


Val Asp Leu Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala Phe Gly 
        115                 120                 125             


Phe Gln Gly Arg Leu Leu His Leu Ser Ala Gly Gln Arg Leu Gly Val 
    130                 135                 140                 


His Leu His Thr Glu Ala Arg Ala Arg His Ala Trp Gln Leu Thr Gln 
145                 150                 155                 160 


Gly Ala Thr Val Leu Gly Leu Phe Arg Val Thr Pro Glu Ile Pro Ala 
                165                 170                 175     


Gly Leu Pro Ser Pro Arg Ser Glu 
            180                 


<210>  173
<211>  170
<212>  PRT
<213>  Homo sapiens

<400>  173

Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu Val Ala Gln Asn Val 
1               5                   10                  15      


Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala 
            20                  25                  30          


Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu Asp Thr Lys Glu 
        35                  40                  45              


Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe Phe Gln Leu Glu 
    50                  55                  60                  


Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser Val Ser Leu Ala 
65                  70                  75                  80  


Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala 
                85                  90                  95      


Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala 
            100                 105                 110         


Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala Gly Gln Arg Leu 
        115                 120                 125             


Gly Val His Leu His Thr Glu Ala Arg Ala Arg His Ala Trp Gln Leu 
    130                 135                 140                 


Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val Thr Pro Glu Ile 
145                 150                 155                 160 


Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu 
                165                 170 


<210>  174
<211>  175
<212>  PRT
<213>  Homo sapiens

<400>  174

Asp Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu 
1               5                   10                  15      


Val Ala Gln Asn Val Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser 
            20                  25                  30          


Asp Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys 
        35                  40                  45              


Glu Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val 
    50                  55                  60                  


Phe Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly 
65                  70                  75                  80  


Ser Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly 
                85                  90                  95      


Ala Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu 
            100                 105                 110         


Ala Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser 
        115                 120                 125             


Ala Gly Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg 
    130                 135                 140                 


His Ala Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg 
145                 150                 155                 160 


Val Thr Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu 
                165                 170                 175 


<210>  175
<211>  203
<212>  PRT
<213>  Homo sapiens

<400>  175

Pro Trp Ala Val Ser Gly Ala Arg Ala Ser Pro Gly Ser Ala Ala Ser 
1               5                   10                  15      


Pro Arg Leu Arg Glu Gly Pro Glu Leu Ser Pro Asp Asp Pro Ala Gly 
            20                  25                  30          


Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu Val Ala Gln Asn 
        35                  40                  45              


Val Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp Pro Gly Leu 
    50                  55                  60                  


Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu Asp Thr Lys 
65                  70                  75                  80  


Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe Phe Gln Leu 
                85                  90                  95      


Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser Val Ser Leu 
            100                 105                 110         


Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala Ala Ala Leu 
        115                 120                 125             


Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser 
    130                 135                 140                 


Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala Gly Gln Arg 
145                 150                 155                 160 


Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg His Ala Trp Gln 
                165                 170                 175     


Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val Thr Pro Glu 
            180                 185                 190         


Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu 
        195                 200             


<210>  176
<211>  378
<212>  PRT
<213>  Artificial sequence

<220>
<223>  dimeric hu 4-1BBL (71-254) connected by (G4S)2 linker

<400>  176

Arg Glu Gly Pro Glu Leu Ser Pro Asp Asp Pro Ala Gly Leu Leu Asp 
1               5                   10                  15      


Leu Arg Gln Gly Met Phe Ala Gln Leu Val Ala Gln Asn Val Leu Leu 
            20                  25                  30          


Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala Gly Val 
        35                  40                  45              


Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu Asp Thr Lys Glu Leu Val 
    50                  55                  60                  


Val Ala Lys Ala Gly Val Tyr Tyr Val Phe Phe Gln Leu Glu Leu Arg 
65                  70                  75                  80  


Arg Val Val Ala Gly Glu Gly Ser Gly Ser Val Ser Leu Ala Leu His 
                85                  90                  95      


Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala Leu Thr 
            100                 105                 110         


Val Asp Leu Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala Phe Gly 
        115                 120                 125             


Phe Gln Gly Arg Leu Leu His Leu Ser Ala Gly Gln Arg Leu Gly Val 
    130                 135                 140                 


His Leu His Thr Glu Ala Arg Ala Arg His Ala Trp Gln Leu Thr Gln 
145                 150                 155                 160 


Gly Ala Thr Val Leu Gly Leu Phe Arg Val Thr Pro Glu Ile Pro Ala 
                165                 170                 175     


Gly Leu Pro Ser Pro Arg Ser Glu Gly Gly Gly Gly Ser Gly Gly Gly 
            180                 185                 190         


Gly Ser Arg Glu Gly Pro Glu Leu Ser Pro Asp Asp Pro Ala Gly Leu 
        195                 200                 205             


Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu Val Ala Gln Asn Val 
    210                 215                 220                 


Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala 
225                 230                 235                 240 


Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu Asp Thr Lys Glu 
                245                 250                 255     


Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe Phe Gln Leu Glu 
            260                 265                 270         


Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser Val Ser Leu Ala 
        275                 280                 285             


Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala 
    290                 295                 300                 


Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala 
305                 310                 315                 320 


Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala Gly Gln Arg Leu 
                325                 330                 335     


Gly Val His Leu His Thr Glu Ala Arg Ala Arg His Ala Trp Gln Leu 
            340                 345                 350         


Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val Thr Pro Glu Ile 
        355                 360                 365             


Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu 
    370                 375             


<210>  177
<211>  194
<212>  PRT
<213>  Artificial sequence

<220>
<223>  monomeric hu 4-1BBL (71-254) plus (G4S)2 linker

<400>  177

Arg Glu Gly Pro Glu Leu Ser Pro Asp Asp Pro Ala Gly Leu Leu Asp 
1               5                   10                  15      


Leu Arg Gln Gly Met Phe Ala Gln Leu Val Ala Gln Asn Val Leu Leu 
            20                  25                  30          


Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala Gly Val 
        35                  40                  45              


Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu Asp Thr Lys Glu Leu Val 
    50                  55                  60                  


Val Ala Lys Ala Gly Val Tyr Tyr Val Phe Phe Gln Leu Glu Leu Arg 
65                  70                  75                  80  


Arg Val Val Ala Gly Glu Gly Ser Gly Ser Val Ser Leu Ala Leu His 
                85                  90                  95      


Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala Leu Thr 
            100                 105                 110         


Val Asp Leu Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala Phe Gly 
        115                 120                 125             


Phe Gln Gly Arg Leu Leu His Leu Ser Ala Gly Gln Arg Leu Gly Val 
    130                 135                 140                 


His Leu His Thr Glu Ala Arg Ala Arg His Ala Trp Gln Leu Thr Gln 
145                 150                 155                 160 


Gly Ala Thr Val Leu Gly Leu Phe Arg Val Thr Pro Glu Ile Pro Ala 
                165                 170                 175     


Gly Leu Pro Ser Pro Arg Ser Glu Gly Gly Gly Gly Ser Gly Gly Gly 
            180                 185                 190         


Gly Ser 
        


<210>  178
<211>  718
<212>  PRT
<213>  Artificial sequence

<220>
<223>  dimeric hu 4-1BBL (71-254)-CH1 Fc knob chain

<400>  178

Arg Glu Gly Pro Glu Leu Ser Pro Asp Asp Pro Ala Gly Leu Leu Asp 
1               5                   10                  15      


Leu Arg Gln Gly Met Phe Ala Gln Leu Val Ala Gln Asn Val Leu Leu 
            20                  25                  30          


Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala Gly Val 
        35                  40                  45              


Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu Asp Thr Lys Glu Leu Val 
    50                  55                  60                  


Val Ala Lys Ala Gly Val Tyr Tyr Val Phe Phe Gln Leu Glu Leu Arg 
65                  70                  75                  80  


Arg Val Val Ala Gly Glu Gly Ser Gly Ser Val Ser Leu Ala Leu His 
                85                  90                  95      


Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala Leu Thr 
            100                 105                 110         


Val Asp Leu Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala Phe Gly 
        115                 120                 125             


Phe Gln Gly Arg Leu Leu His Leu Ser Ala Gly Gln Arg Leu Gly Val 
    130                 135                 140                 


His Leu His Thr Glu Ala Arg Ala Arg His Ala Trp Gln Leu Thr Gln 
145                 150                 155                 160 


Gly Ala Thr Val Leu Gly Leu Phe Arg Val Thr Pro Glu Ile Pro Ala 
                165                 170                 175     


Gly Leu Pro Ser Pro Arg Ser Glu Gly Gly Gly Gly Ser Gly Gly Gly 
            180                 185                 190         


Gly Ser Arg Glu Gly Pro Glu Leu Ser Pro Asp Asp Pro Ala Gly Leu 
        195                 200                 205             


Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu Val Ala Gln Asn Val 
    210                 215                 220                 


Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala 
225                 230                 235                 240 


Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu Asp Thr Lys Glu 
                245                 250                 255     


Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe Phe Gln Leu Glu 
            260                 265                 270         


Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser Val Ser Leu Ala 
        275                 280                 285             


Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala 
    290                 295                 300                 


Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala 
305                 310                 315                 320 


Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala Gly Gln Arg Leu 
                325                 330                 335     


Gly Val His Leu His Thr Glu Ala Arg Ala Arg His Ala Trp Gln Leu 
            340                 345                 350         


Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val Thr Pro Glu Ile 
        355                 360                 365             


Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu Gly Gly Gly Gly Ser Gly 
    370                 375                 380                 


Gly Gly Gly Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
385                 390                 395                 400 


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
                405                 410                 415     


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
            420                 425                 430         


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
        435                 440                 445             


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
    450                 455                 460                 


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
465                 470                 475                 480 


Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
                485                 490                 495     


Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe 
            500                 505                 510         


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
        515                 520                 525             


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
    530                 535                 540                 


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
545                 550                 555                 560 


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
                565                 570                 575     


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
            580                 585                 590         


Lys Val Ser Asn Lys Ala Leu Gly Ala Pro Ile Glu Lys Thr Ile Ser 
        595                 600                 605             


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
    610                 615                 620                 


Cys Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Trp Cys Leu Val 
625                 630                 635                 640 


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
                645                 650                 655     


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
            660                 665                 670         


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
        675                 680                 685             


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
    690                 695                 700                 


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
705                 710                 715             


<210>  179
<211>  301
<212>  PRT
<213>  Artificial sequence

<220>
<223>  monomeric hu 4-1BBL (71-254)-CL

<400>  179

Arg Glu Gly Pro Glu Leu Ser Pro Asp Asp Pro Ala Gly Leu Leu Asp 
1               5                   10                  15      


Leu Arg Gln Gly Met Phe Ala Gln Leu Val Ala Gln Asn Val Leu Leu 
            20                  25                  30          


Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala Gly Val 
        35                  40                  45              


Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu Asp Thr Lys Glu Leu Val 
    50                  55                  60                  


Val Ala Lys Ala Gly Val Tyr Tyr Val Phe Phe Gln Leu Glu Leu Arg 
65                  70                  75                  80  


Arg Val Val Ala Gly Glu Gly Ser Gly Ser Val Ser Leu Ala Leu His 
                85                  90                  95      


Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala Leu Thr 
            100                 105                 110         


Val Asp Leu Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala Phe Gly 
        115                 120                 125             


Phe Gln Gly Arg Leu Leu His Leu Ser Ala Gly Gln Arg Leu Gly Val 
    130                 135                 140                 


His Leu His Thr Glu Ala Arg Ala Arg His Ala Trp Gln Leu Thr Gln 
145                 150                 155                 160 


Gly Ala Thr Val Leu Gly Leu Phe Arg Val Thr Pro Glu Ile Pro Ala 
                165                 170                 175     


Gly Leu Pro Ser Pro Arg Ser Glu Gly Gly Gly Gly Ser Gly Gly Gly 
            180                 185                 190         


Gly Ser Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser 
        195                 200                 205             


Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn 
    210                 215                 220                 


Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala 
225                 230                 235                 240 


Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys 
                245                 250                 255     


Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp 
            260                 265                 270         


Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu 
        275                 280                 285             


Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    290                 295                 300     


<210>  180
<211>  205
<212>  PRT
<213>  Homo sapiens

<400>  180

Ala Cys Pro Trp Ala Val Ser Gly Ala Arg Ala Ser Pro Gly Ser Ala 
1               5                   10                  15      


Ala Ser Pro Arg Leu Arg Glu Gly Pro Glu Leu Ser Pro Asp Asp Pro 
            20                  25                  30          


Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu Val Ala 
        35                  40                  45              


Gln Asn Val Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp Pro 
    50                  55                  60                  


Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu Asp 
65                  70                  75                  80  


Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe Phe 
                85                  90                  95      


Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser Val 
            100                 105                 110         


Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala Ala 
        115                 120                 125             


Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala Arg 
    130                 135                 140                 


Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala Gly 
145                 150                 155                 160 


Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg His Ala 
                165                 170                 175     


Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val Thr 
            180                 185                 190         


Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu 
        195                 200                 205 


<210>  181
<211>  133
<212>  PRT
<213>  Homo sapiens

<400>  181

Gln Val Ser His Arg Tyr Pro Arg Ile Gln Ser Ile Lys Val Gln Phe 
1               5                   10                  15      


Thr Glu Tyr Lys Lys Glu Lys Gly Phe Ile Leu Thr Ser Gln Lys Glu 
            20                  25                  30          


Asp Glu Ile Met Lys Val Gln Asn Asn Ser Val Ile Ile Asn Cys Asp 
        35                  40                  45              


Gly Phe Tyr Leu Ile Ser Leu Lys Gly Tyr Phe Ser Gln Glu Val Asn 
    50                  55                  60                  


Ile Ser Leu His Tyr Gln Lys Asp Glu Glu Pro Leu Phe Gln Leu Lys 
65                  70                  75                  80  


Lys Val Arg Ser Val Asn Ser Leu Met Val Ala Ser Leu Thr Tyr Lys 
                85                  90                  95      


Asp Lys Val Tyr Leu Asn Val Thr Thr Asp Asn Thr Ser Leu Asp Asp 
            100                 105                 110         


Phe His Val Asn Gly Gly Glu Leu Ile Leu Ile His Gln Asn Pro Gly 
        115                 120                 125             


Glu Phe Cys Val Leu 
    130             


<210>  182
<211>  132
<212>  PRT
<213>  Homo sapiens

<400>  182

Val Ser His Arg Tyr Pro Arg Ile Gln Ser Ile Lys Val Gln Phe Thr 
1               5                   10                  15      


Glu Tyr Lys Lys Glu Lys Gly Phe Ile Leu Thr Ser Gln Lys Glu Asp 
            20                  25                  30          


Glu Ile Met Lys Val Gln Asn Asn Ser Val Ile Ile Asn Cys Asp Gly 
        35                  40                  45              


Phe Tyr Leu Ile Ser Leu Lys Gly Tyr Phe Ser Gln Glu Val Asn Ile 
    50                  55                  60                  


Ser Leu His Tyr Gln Lys Asp Glu Glu Pro Leu Phe Gln Leu Lys Lys 
65                  70                  75                  80  


Val Arg Ser Val Asn Ser Leu Met Val Ala Ser Leu Thr Tyr Lys Asp 
                85                  90                  95      


Lys Val Tyr Leu Asn Val Thr Thr Asp Asn Thr Ser Leu Asp Asp Phe 
            100                 105                 110         


His Val Asn Gly Gly Glu Leu Ile Leu Ile His Gln Asn Pro Gly Glu 
        115                 120                 125             


Phe Cys Val Leu 
    130         


<210>  183
<211>  178
<212>  PRT
<213>  Homo sapiens

<400>  183

Arg Glu Gly Pro Glu Leu Ser Pro Asp Asp Pro Ala Gly Leu Leu Asp 
1               5                   10                  15      


Leu Arg Gln Gly Met Phe Ala Gln Leu Val Ala Gln Asn Val Leu Leu 
            20                  25                  30          


Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala Gly Val 
        35                  40                  45              


Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu Asp Thr Lys Glu Leu Val 
    50                  55                  60                  


Val Ala Lys Ala Gly Val Tyr Tyr Val Phe Phe Gln Leu Glu Leu Arg 
65                  70                  75                  80  


Arg Val Val Ala Gly Glu Gly Ser Gly Ser Val Ser Leu Ala Leu His 
                85                  90                  95      


Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala Leu Thr 
            100                 105                 110         


Val Asp Leu Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala Phe Gly 
        115                 120                 125             


Phe Gln Gly Arg Leu Leu His Leu Ser Ala Gly Gln Arg Leu Gly Val 
    130                 135                 140                 


His Leu His Thr Glu Ala Arg Ala Arg His Ala Trp Gln Leu Thr Gln 
145                 150                 155                 160 


Gly Ala Thr Val Leu Gly Leu Phe Arg Val Thr Pro Glu Ile Pro Ala 
                165                 170                 175     


Gly Leu 
        


<210>  184
<211>  366
<212>  PRT
<213>  Artificial sequence

<220>
<223>  dimeric hu 4-1BBL (71-248) connected by (G4S)2 linker

<400>  184

Arg Glu Gly Pro Glu Leu Ser Pro Asp Asp Pro Ala Gly Leu Leu Asp 
1               5                   10                  15      


Leu Arg Gln Gly Met Phe Ala Gln Leu Val Ala Gln Asn Val Leu Leu 
            20                  25                  30          


Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala Gly Val 
        35                  40                  45              


Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu Asp Thr Lys Glu Leu Val 
    50                  55                  60                  


Val Ala Lys Ala Gly Val Tyr Tyr Val Phe Phe Gln Leu Glu Leu Arg 
65                  70                  75                  80  


Arg Val Val Ala Gly Glu Gly Ser Gly Ser Val Ser Leu Ala Leu His 
                85                  90                  95      


Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala Leu Thr 
            100                 105                 110         


Val Asp Leu Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala Phe Gly 
        115                 120                 125             


Phe Gln Gly Arg Leu Leu His Leu Ser Ala Gly Gln Arg Leu Gly Val 
    130                 135                 140                 


His Leu His Thr Glu Ala Arg Ala Arg His Ala Trp Gln Leu Thr Gln 
145                 150                 155                 160 


Gly Ala Thr Val Leu Gly Leu Phe Arg Val Thr Pro Glu Ile Pro Ala 
                165                 170                 175     


Gly Leu Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Arg Glu Gly Pro 
            180                 185                 190         


Glu Leu Ser Pro Asp Asp Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly 
        195                 200                 205             


Met Phe Ala Gln Leu Val Ala Gln Asn Val Leu Leu Ile Asp Gly Pro 
    210                 215                 220                 


Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala Gly Val Ser Leu Thr Gly 
225                 230                 235                 240 


Gly Leu Ser Tyr Lys Glu Asp Thr Lys Glu Leu Val Val Ala Lys Ala 
                245                 250                 255     


Gly Val Tyr Tyr Val Phe Phe Gln Leu Glu Leu Arg Arg Val Val Ala 
            260                 265                 270         


Gly Glu Gly Ser Gly Ser Val Ser Leu Ala Leu His Leu Gln Pro Leu 
        275                 280                 285             


Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala Leu Thr Val Asp Leu Pro 
    290                 295                 300                 


Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg 
305                 310                 315                 320 


Leu Leu His Leu Ser Ala Gly Gln Arg Leu Gly Val His Leu His Thr 
                325                 330                 335     


Glu Ala Arg Ala Arg His Ala Trp Gln Leu Thr Gln Gly Ala Thr Val 
            340                 345                 350         


Leu Gly Leu Phe Arg Val Thr Pro Glu Ile Pro Ala Gly Leu 
        355                 360                 365     


<210>  185
<211>  360
<212>  PRT
<213>  Artificial sequence

<220>
<223>  dimeric hu 4-1BBL (80-254) connected by (G4S)2 linker

<400>  185

Asp Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu 
1               5                   10                  15      


Val Ala Gln Asn Val Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser 
            20                  25                  30          


Asp Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys 
        35                  40                  45              


Glu Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val 
    50                  55                  60                  


Phe Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly 
65                  70                  75                  80  


Ser Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly 
                85                  90                  95      


Ala Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu 
            100                 105                 110         


Ala Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser 
        115                 120                 125             


Ala Gly Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg 
    130                 135                 140                 


His Ala Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg 
145                 150                 155                 160 


Val Thr Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu Gly 
                165                 170                 175     


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Pro Ala Gly Leu Leu Asp 
            180                 185                 190         


Leu Arg Gln Gly Met Phe Ala Gln Leu Val Ala Gln Asn Val Leu Leu 
        195                 200                 205             


Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala Gly Val 
    210                 215                 220                 


Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu Asp Thr Lys Glu Leu Val 
225                 230                 235                 240 


Val Ala Lys Ala Gly Val Tyr Tyr Val Phe Phe Gln Leu Glu Leu Arg 
                245                 250                 255     


Arg Val Val Ala Gly Glu Gly Ser Gly Ser Val Ser Leu Ala Leu His 
            260                 265                 270         


Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala Leu Thr 
        275                 280                 285             


Val Asp Leu Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala Phe Gly 
    290                 295                 300                 


Phe Gln Gly Arg Leu Leu His Leu Ser Ala Gly Gln Arg Leu Gly Val 
305                 310                 315                 320 


His Leu His Thr Glu Ala Arg Ala Arg His Ala Trp Gln Leu Thr Gln 
                325                 330                 335     


Gly Ala Thr Val Leu Gly Leu Phe Arg Val Thr Pro Glu Ile Pro Ala 
            340                 345                 350         


Gly Leu Pro Ser Pro Arg Ser Glu 
        355                 360 


<210>  186
<211>  416
<212>  PRT
<213>  Artificial sequence

<220>
<223>  dimeric hu 4-1BBL (52-254) connected by (G4S)2 linker

<400>  186

Pro Trp Ala Val Ser Gly Ala Arg Ala Ser Pro Gly Ser Ala Ala Ser 
1               5                   10                  15      


Pro Arg Leu Arg Glu Gly Pro Glu Leu Ser Pro Asp Asp Pro Ala Gly 
            20                  25                  30          


Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu Val Ala Gln Asn 
        35                  40                  45              


Val Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp Pro Gly Leu 
    50                  55                  60                  


Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu Asp Thr Lys 
65                  70                  75                  80  


Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe Phe Gln Leu 
                85                  90                  95      


Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser Val Ser Leu 
            100                 105                 110         


Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala Ala Ala Leu 
        115                 120                 125             


Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser 
    130                 135                 140                 


Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala Gly Gln Arg 
145                 150                 155                 160 


Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg His Ala Trp Gln 
                165                 170                 175     


Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val Thr Pro Glu 
            180                 185                 190         


Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu Gly Gly Gly Gly Ser 
        195                 200                 205             


Gly Gly Gly Gly Ser Pro Trp Ala Val Ser Gly Ala Arg Ala Ser Pro 
    210                 215                 220                 


Gly Ser Ala Ala Ser Pro Arg Leu Arg Glu Gly Pro Glu Leu Ser Pro 
225                 230                 235                 240 


Asp Asp Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln 
                245                 250                 255     


Leu Val Ala Gln Asn Val Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr 
            260                 265                 270         


Ser Asp Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr 
        275                 280                 285             


Lys Glu Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr 
    290                 295                 300                 


Val Phe Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser 
305                 310                 315                 320 


Gly Ser Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala 
                325                 330                 335     


Gly Ala Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser 
            340                 345                 350         


Glu Ala Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu 
        355                 360                 365             


Ser Ala Gly Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala 
    370                 375                 380                 


Arg His Ala Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe 
385                 390                 395                 400 


Arg Val Thr Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu 
                405                 410                 415     


<210>  187
<211>  189
<212>  PRT
<213>  Artificial sequence

<220>
<223>  monomeric hu 4-1BBL (71-254) plus (G4S)1 linker

<400>  187

Arg Glu Gly Pro Glu Leu Ser Pro Asp Asp Pro Ala Gly Leu Leu Asp 
1               5                   10                  15      


Leu Arg Gln Gly Met Phe Ala Gln Leu Val Ala Gln Asn Val Leu Leu 
            20                  25                  30          


Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala Gly Val 
        35                  40                  45              


Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu Asp Thr Lys Glu Leu Val 
    50                  55                  60                  


Val Ala Lys Ala Gly Val Tyr Tyr Val Phe Phe Gln Leu Glu Leu Arg 
65                  70                  75                  80  


Arg Val Val Ala Gly Glu Gly Ser Gly Ser Val Ser Leu Ala Leu His 
                85                  90                  95      


Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala Leu Thr 
            100                 105                 110         


Val Asp Leu Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala Phe Gly 
        115                 120                 125             


Phe Gln Gly Arg Leu Leu His Leu Ser Ala Gly Gln Arg Leu Gly Val 
    130                 135                 140                 


His Leu His Thr Glu Ala Arg Ala Arg His Ala Trp Gln Leu Thr Gln 
145                 150                 155                 160 


Gly Ala Thr Val Leu Gly Leu Phe Arg Val Thr Pro Glu Ile Pro Ala 
                165                 170                 175     


Gly Leu Pro Ser Pro Arg Ser Glu Gly Gly Gly Gly Ser 
            180                 185                 


<210>  188
<211>  188
<212>  PRT
<213>  Artificial sequence

<220>
<223>  monomeric hu 4-1BBL (71-248) plus (G4S)2 linker

<400>  188

Arg Glu Gly Pro Glu Leu Ser Pro Asp Asp Pro Ala Gly Leu Leu Asp 
1               5                   10                  15      


Leu Arg Gln Gly Met Phe Ala Gln Leu Val Ala Gln Asn Val Leu Leu 
            20                  25                  30          


Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala Gly Val 
        35                  40                  45              


Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu Asp Thr Lys Glu Leu Val 
    50                  55                  60                  


Val Ala Lys Ala Gly Val Tyr Tyr Val Phe Phe Gln Leu Glu Leu Arg 
65                  70                  75                  80  


Arg Val Val Ala Gly Glu Gly Ser Gly Ser Val Ser Leu Ala Leu His 
                85                  90                  95      


Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala Leu Thr 
            100                 105                 110         


Val Asp Leu Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala Phe Gly 
        115                 120                 125             


Phe Gln Gly Arg Leu Leu His Leu Ser Ala Gly Gln Arg Leu Gly Val 
    130                 135                 140                 


His Leu His Thr Glu Ala Arg Ala Arg His Ala Trp Gln Leu Thr Gln 
145                 150                 155                 160 


Gly Ala Thr Val Leu Gly Leu Phe Arg Val Thr Pro Glu Ile Pro Ala 
                165                 170                 175     


Gly Leu Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            180                 185             


<210>  189
<211>  183
<212>  PRT
<213>  Artificial sequence

<220>
<223>  monomeric hu 4-1BBL (71-248) plus (G4S)1 linker

<400>  189

Arg Glu Gly Pro Glu Leu Ser Pro Asp Asp Pro Ala Gly Leu Leu Asp 
1               5                   10                  15      


Leu Arg Gln Gly Met Phe Ala Gln Leu Val Ala Gln Asn Val Leu Leu 
            20                  25                  30          


Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala Gly Val 
        35                  40                  45              


Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu Asp Thr Lys Glu Leu Val 
    50                  55                  60                  


Val Ala Lys Ala Gly Val Tyr Tyr Val Phe Phe Gln Leu Glu Leu Arg 
65                  70                  75                  80  


Arg Val Val Ala Gly Glu Gly Ser Gly Ser Val Ser Leu Ala Leu His 
                85                  90                  95      


Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala Leu Thr 
            100                 105                 110         


Val Asp Leu Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala Phe Gly 
        115                 120                 125             


Phe Gln Gly Arg Leu Leu His Leu Ser Ala Gly Gln Arg Leu Gly Val 
    130                 135                 140                 


His Leu His Thr Glu Ala Arg Ala Arg His Ala Trp Gln Leu Thr Gln 
145                 150                 155                 160 


Gly Ala Thr Val Leu Gly Leu Phe Arg Val Thr Pro Glu Ile Pro Ala 
                165                 170                 175     


Gly Leu Gly Gly Gly Gly Ser 
            180             


<210>  190
<211>  276
<212>  PRT
<213>  Artificial sequence

<220>
<223>  dimeric huOX40L (51-183) connected by (G4S)2 linker

<400>  190

Gln Val Ser His Arg Tyr Pro Arg Ile Gln Ser Ile Lys Val Gln Phe 
1               5                   10                  15      


Thr Glu Tyr Lys Lys Glu Lys Gly Phe Ile Leu Thr Ser Gln Lys Glu 
            20                  25                  30          


Asp Glu Ile Met Lys Val Gln Asn Asn Ser Val Ile Ile Asn Cys Asp 
        35                  40                  45              


Gly Phe Tyr Leu Ile Ser Leu Lys Gly Tyr Phe Ser Gln Glu Val Asn 
    50                  55                  60                  


Ile Ser Leu His Tyr Gln Lys Asp Glu Glu Pro Leu Phe Gln Leu Lys 
65                  70                  75                  80  


Lys Val Arg Ser Val Asn Ser Leu Met Val Ala Ser Leu Thr Tyr Lys 
                85                  90                  95      


Asp Lys Val Tyr Leu Asn Val Thr Thr Asp Asn Thr Ser Leu Asp Asp 
            100                 105                 110         


Phe His Val Asn Gly Gly Glu Leu Ile Leu Ile His Gln Asn Pro Gly 
        115                 120                 125             


Glu Phe Cys Val Leu Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln 
    130                 135                 140                 


Val Ser His Arg Tyr Pro Arg Ile Gln Ser Ile Lys Val Gln Phe Thr 
145                 150                 155                 160 


Glu Tyr Lys Lys Glu Lys Gly Phe Ile Leu Thr Ser Gln Lys Glu Asp 
                165                 170                 175     


Glu Ile Met Lys Val Gln Asn Asn Ser Val Ile Ile Asn Cys Asp Gly 
            180                 185                 190         


Phe Tyr Leu Ile Ser Leu Lys Gly Tyr Phe Ser Gln Glu Val Asn Ile 
        195                 200                 205             


Ser Leu His Tyr Gln Lys Asp Glu Glu Pro Leu Phe Gln Leu Lys Lys 
    210                 215                 220                 


Val Arg Ser Val Asn Ser Leu Met Val Ala Ser Leu Thr Tyr Lys Asp 
225                 230                 235                 240 


Lys Val Tyr Leu Asn Val Thr Thr Asp Asn Thr Ser Leu Asp Asp Phe 
                245                 250                 255     


His Val Asn Gly Gly Glu Leu Ile Leu Ile His Gln Asn Pro Gly Glu 
            260                 265                 270         


Phe Cys Val Leu 
        275     


<210>  191
<211>  274
<212>  PRT
<213>  Artificial sequence

<220>
<223>  dimeric huOX40L (52-183) connected by (G4S)2 linker

<400>  191

Val Ser His Arg Tyr Pro Arg Ile Gln Ser Ile Lys Val Gln Phe Thr 
1               5                   10                  15      


Glu Tyr Lys Lys Glu Lys Gly Phe Ile Leu Thr Ser Gln Lys Glu Asp 
            20                  25                  30          


Glu Ile Met Lys Val Gln Asn Asn Ser Val Ile Ile Asn Cys Asp Gly 
        35                  40                  45              


Phe Tyr Leu Ile Ser Leu Lys Gly Tyr Phe Ser Gln Glu Val Asn Ile 
    50                  55                  60                  


Ser Leu His Tyr Gln Lys Asp Glu Glu Pro Leu Phe Gln Leu Lys Lys 
65                  70                  75                  80  


Val Arg Ser Val Asn Ser Leu Met Val Ala Ser Leu Thr Tyr Lys Asp 
                85                  90                  95      


Lys Val Tyr Leu Asn Val Thr Thr Asp Asn Thr Ser Leu Asp Asp Phe 
            100                 105                 110         


His Val Asn Gly Gly Glu Leu Ile Leu Ile His Gln Asn Pro Gly Glu 
        115                 120                 125             


Phe Cys Val Leu Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Val Ser 
    130                 135                 140                 


His Arg Tyr Pro Arg Ile Gln Ser Ile Lys Val Gln Phe Thr Glu Tyr 
145                 150                 155                 160 


Lys Lys Glu Lys Gly Phe Ile Leu Thr Ser Gln Lys Glu Asp Glu Ile 
                165                 170                 175     


Met Lys Val Gln Asn Asn Ser Val Ile Ile Asn Cys Asp Gly Phe Tyr 
            180                 185                 190         


Leu Ile Ser Leu Lys Gly Tyr Phe Ser Gln Glu Val Asn Ile Ser Leu 
        195                 200                 205             


His Tyr Gln Lys Asp Glu Glu Pro Leu Phe Gln Leu Lys Lys Val Arg 
    210                 215                 220                 


Ser Val Asn Ser Leu Met Val Ala Ser Leu Thr Tyr Lys Asp Lys Val 
225                 230                 235                 240 


Tyr Leu Asn Val Thr Thr Asp Asn Thr Ser Leu Asp Asp Phe His Val 
                245                 250                 255     


Asn Gly Gly Glu Leu Ile Leu Ile His Gln Asn Pro Gly Glu Phe Cys 
            260                 265                 270         


Val Leu 
        


<210>  192
<211>  164
<212>  PRT
<213>  Homo sapiens

<400>  192

Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu Val Ala Gln Asn Val 
1               5                   10                  15      


Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala 
            20                  25                  30          


Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu Asp Thr Lys Glu 
        35                  40                  45              


Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe Phe Gln Leu Glu 
    50                  55                  60                  


Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser Val Ser Leu Ala 
65                  70                  75                  80  


Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala 
                85                  90                  95      


Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala 
            100                 105                 110         


Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala Gly Gln Arg Leu 
        115                 120                 125             


Gly Val His Leu His Thr Glu Ala Arg Ala Arg His Ala Trp Gln Leu 
    130                 135                 140                 


Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val Thr Pro Glu Ile 
145                 150                 155                 160 


Pro Ala Gly Leu 
                


<210>  193
<211>  169
<212>  PRT
<213>  Homo sapiens

<400>  193

Asp Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu 
1               5                   10                  15      


Val Ala Gln Asn Val Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser 
            20                  25                  30          


Asp Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys 
        35                  40                  45              


Glu Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val 
    50                  55                  60                  


Phe Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly 
65                  70                  75                  80  


Ser Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly 
                85                  90                  95      


Ala Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu 
            100                 105                 110         


Ala Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser 
        115                 120                 125             


Ala Gly Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg 
    130                 135                 140                 


His Ala Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg 
145                 150                 155                 160 


Val Thr Pro Glu Ile Pro Ala Gly Leu 
                165                 


<210>  194
<211>  197
<212>  PRT
<213>  Homo sapiens

<400>  194

Pro Trp Ala Val Ser Gly Ala Arg Ala Ser Pro Gly Ser Ala Ala Ser 
1               5                   10                  15      


Pro Arg Leu Arg Glu Gly Pro Glu Leu Ser Pro Asp Asp Pro Ala Gly 
            20                  25                  30          


Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu Val Ala Gln Asn 
        35                  40                  45              


Val Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp Pro Gly Leu 
    50                  55                  60                  


Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu Asp Thr Lys 
65                  70                  75                  80  


Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe Phe Gln Leu 
                85                  90                  95      


Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser Val Ser Leu 
            100                 105                 110         


Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala Ala Ala Leu 
        115                 120                 125             


Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser 
    130                 135                 140                 


Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala Gly Gln Arg 
145                 150                 155                 160 


Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg His Ala Trp Gln 
                165                 170                 175     


Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val Thr Pro Glu 
            180                 185                 190         


Ile Pro Ala Gly Leu 
        195         


<210>  195
<211>  620
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Dimeric hu OX40L (51-183)  - CL* Fc knob chain

<400>  195

Gln Val Ser His Arg Tyr Pro Arg Ile Gln Ser Ile Lys Val Gln Phe 
1               5                   10                  15      


Thr Glu Tyr Lys Lys Glu Lys Gly Phe Ile Leu Thr Ser Gln Lys Glu 
            20                  25                  30          


Asp Glu Ile Met Lys Val Gln Asp Asn Ser Val Ile Ile Asn Cys Asp 
        35                  40                  45              


Gly Phe Tyr Leu Ile Ser Leu Lys Gly Tyr Phe Ser Gln Glu Val Asp 
    50                  55                  60                  


Ile Ser Leu His Tyr Gln Lys Asp Glu Glu Pro Leu Phe Gln Leu Lys 
65                  70                  75                  80  


Lys Val Arg Ser Val Asn Ser Leu Met Val Ala Ser Leu Thr Tyr Lys 
                85                  90                  95      


Asp Lys Val Tyr Leu Asn Val Thr Thr Asp Asn Thr Ser Leu Asp Asp 
            100                 105                 110         


Phe His Val Asn Gly Gly Glu Leu Ile Leu Ile His Gln Asn Pro Gly 
        115                 120                 125             


Glu Phe Cys Val Leu Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln 
    130                 135                 140                 


Val Ser His Arg Tyr Pro Arg Ile Gln Ser Ile Lys Val Gln Phe Thr 
145                 150                 155                 160 


Glu Tyr Lys Lys Glu Lys Gly Phe Ile Leu Thr Ser Gln Lys Glu Asp 
                165                 170                 175     


Glu Ile Met Lys Val Gln Asp Asn Ser Val Ile Ile Asn Cys Asp Gly 
            180                 185                 190         


Phe Tyr Leu Ile Ser Leu Lys Gly Tyr Phe Ser Gln Glu Val Asp Ile 
        195                 200                 205             


Ser Leu His Tyr Gln Lys Asp Glu Glu Pro Leu Phe Gln Leu Lys Lys 
    210                 215                 220                 


Val Arg Ser Val Asn Ser Leu Met Val Ala Ser Leu Thr Tyr Lys Asp 
225                 230                 235                 240 


Lys Val Tyr Leu Asn Val Thr Thr Asp Asn Thr Ser Leu Asp Asp Phe 
                245                 250                 255     


His Val Asn Gly Gly Glu Leu Ile Leu Ile His Gln Asn Pro Gly Glu 
            260                 265                 270         


Phe Cys Val Leu Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Arg Thr 
        275                 280                 285             


Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Arg Lys Leu 
    290                 295                 300                 


Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro 
305                 310                 315                 320 


Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly 
                325                 330                 335     


Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr 
            340                 345                 350         


Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His 
        355                 360                 365             


Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val 
    370                 375                 380                 


Thr Lys Ser Phe Asn Arg Gly Glu Cys Asp Lys Thr His Thr Cys Pro 
385                 390                 395                 400 


Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe 
                405                 410                 415     


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
            420                 425                 430         


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
        435                 440                 445             


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
    450                 455                 460                 


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
465                 470                 475                 480 


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
                485                 490                 495     


Ser Asn Lys Ala Leu Gly Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
            500                 505                 510         


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Cys Arg 
        515                 520                 525             


Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly 
    530                 535                 540                 


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
545                 550                 555                 560 


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
                565                 570                 575     


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
            580                 585                 590         


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
        595                 600                 605             


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    610                 615                 620 


<210>  196
<211>  246
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Monomeric hu OX40L (51-183) - CH1*

<400>  196

Gln Val Ser His Arg Tyr Pro Arg Ile Gln Ser Ile Lys Val Gln Phe 
1               5                   10                  15      


Thr Glu Tyr Lys Lys Glu Lys Gly Phe Ile Leu Thr Ser Gln Lys Glu 
            20                  25                  30          


Asp Glu Ile Met Lys Val Gln Asp Asn Ser Val Ile Ile Asn Cys Asp 
        35                  40                  45              


Gly Phe Tyr Leu Ile Ser Leu Lys Gly Tyr Phe Ser Gln Glu Val Asp 
    50                  55                  60                  


Ile Ser Leu His Tyr Gln Lys Asp Glu Glu Pro Leu Phe Gln Leu Lys 
65                  70                  75                  80  


Lys Val Arg Ser Val Asn Ser Leu Met Val Ala Ser Leu Thr Tyr Lys 
                85                  90                  95      


Asp Lys Val Tyr Leu Asn Val Thr Thr Asp Asn Thr Ser Leu Asp Asp 
            100                 105                 110         


Phe His Val Asn Gly Gly Glu Leu Ile Leu Ile His Gln Asn Pro Gly 
        115                 120                 125             


Glu Phe Cys Val Leu Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala 
    130                 135                 140                 


Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser 
145                 150                 155                 160 


Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Glu Asp Tyr Phe 
                165                 170                 175     


Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
            180                 185                 190         


Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
        195                 200                 205             


Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr 
    210                 215                 220                 


Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Glu Lys 
225                 230                 235                 240 


Val Glu Pro Lys Ser Cys 
                245     


<210>  197
<211>  2201
<212>  PRT
<213>  Homo sapiens

<400>  197

Met Gly Ala Met Thr Gln Leu Leu Ala Gly Val Phe Leu Ala Phe Leu 
1               5                   10                  15      


Ala Leu Ala Thr Glu Gly Gly Val Leu Lys Lys Val Ile Arg His Lys 
            20                  25                  30          


Arg Gln Ser Gly Val Asn Ala Thr Leu Pro Glu Glu Asn Gln Pro Val 
        35                  40                  45              


Val Phe Asn His Val Tyr Asn Ile Lys Leu Pro Val Gly Ser Gln Cys 
    50                  55                  60                  


Ser Val Asp Leu Glu Ser Ala Ser Gly Glu Lys Asp Leu Ala Pro Pro 
65                  70                  75                  80  


Ser Glu Pro Ser Glu Ser Phe Gln Glu His Thr Val Asp Gly Glu Asn 
                85                  90                  95      


Gln Ile Val Phe Thr His Arg Ile Asn Ile Pro Arg Arg Ala Cys Gly 
            100                 105                 110         


Cys Ala Ala Ala Pro Asp Val Lys Glu Leu Leu Ser Arg Leu Glu Glu 
        115                 120                 125             


Leu Glu Asn Leu Val Ser Ser Leu Arg Glu Gln Cys Thr Ala Gly Ala 
    130                 135                 140                 


Gly Cys Cys Leu Gln Pro Ala Thr Gly Arg Leu Asp Thr Arg Pro Phe 
145                 150                 155                 160 


Cys Ser Gly Arg Gly Asn Phe Ser Thr Glu Gly Cys Gly Cys Val Cys 
                165                 170                 175     


Glu Pro Gly Trp Lys Gly Pro Asn Cys Ser Glu Pro Glu Cys Pro Gly 
            180                 185                 190         


Asn Cys His Leu Arg Gly Arg Cys Ile Asp Gly Gln Cys Ile Cys Asp 
        195                 200                 205             


Asp Gly Phe Thr Gly Glu Asp Cys Ser Gln Leu Ala Cys Pro Ser Asp 
    210                 215                 220                 


Cys Asn Asp Gln Gly Lys Cys Val Asn Gly Val Cys Ile Cys Phe Glu 
225                 230                 235                 240 


Gly Tyr Ala Gly Ala Asp Cys Ser Arg Glu Ile Cys Pro Val Pro Cys 
                245                 250                 255     


Ser Glu Glu His Gly Thr Cys Val Asp Gly Leu Cys Val Cys His Asp 
            260                 265                 270         


Gly Phe Ala Gly Asp Asp Cys Asn Lys Pro Leu Cys Leu Asn Asn Cys 
        275                 280                 285             


Tyr Asn Arg Gly Arg Cys Val Glu Asn Glu Cys Val Cys Asp Glu Gly 
    290                 295                 300                 


Phe Thr Gly Glu Asp Cys Ser Glu Leu Ile Cys Pro Asn Asp Cys Phe 
305                 310                 315                 320 


Asp Arg Gly Arg Cys Ile Asn Gly Thr Cys Tyr Cys Glu Glu Gly Phe 
                325                 330                 335     


Thr Gly Glu Asp Cys Gly Lys Pro Thr Cys Pro His Ala Cys His Thr 
            340                 345                 350         


Gln Gly Arg Cys Glu Glu Gly Gln Cys Val Cys Asp Glu Gly Phe Ala 
        355                 360                 365             


Gly Val Asp Cys Ser Glu Lys Arg Cys Pro Ala Asp Cys His Asn Arg 
    370                 375                 380                 


Gly Arg Cys Val Asp Gly Arg Cys Glu Cys Asp Asp Gly Phe Thr Gly 
385                 390                 395                 400 


Ala Asp Cys Gly Glu Leu Lys Cys Pro Asn Gly Cys Ser Gly His Gly 
                405                 410                 415     


Arg Cys Val Asn Gly Gln Cys Val Cys Asp Glu Gly Tyr Thr Gly Glu 
            420                 425                 430         


Asp Cys Ser Gln Leu Arg Cys Pro Asn Asp Cys His Ser Arg Gly Arg 
        435                 440                 445             


Cys Val Glu Gly Lys Cys Val Cys Glu Gln Gly Phe Lys Gly Tyr Asp 
    450                 455                 460                 


Cys Ser Asp Met Ser Cys Pro Asn Asp Cys His Gln His Gly Arg Cys 
465                 470                 475                 480 


Val Asn Gly Met Cys Val Cys Asp Asp Gly Tyr Thr Gly Glu Asp Cys 
                485                 490                 495     


Arg Asp Arg Gln Cys Pro Arg Asp Cys Ser Asn Arg Gly Leu Cys Val 
            500                 505                 510         


Asp Gly Gln Cys Val Cys Glu Asp Gly Phe Thr Gly Pro Asp Cys Ala 
        515                 520                 525             


Glu Leu Ser Cys Pro Asn Asp Cys His Gly Gln Gly Arg Cys Val Asn 
    530                 535                 540                 


Gly Gln Cys Val Cys His Glu Gly Phe Met Gly Lys Asp Cys Lys Glu 
545                 550                 555                 560 


Gln Arg Cys Pro Ser Asp Cys His Gly Gln Gly Arg Cys Val Asp Gly 
                565                 570                 575     


Gln Cys Ile Cys His Glu Gly Phe Thr Gly Leu Asp Cys Gly Gln His 
            580                 585                 590         


Ser Cys Pro Ser Asp Cys Asn Asn Leu Gly Gln Cys Val Ser Gly Arg 
        595                 600                 605             


Cys Ile Cys Asn Glu Gly Tyr Ser Gly Glu Asp Cys Ser Glu Val Ser 
    610                 615                 620                 


Pro Pro Lys Asp Leu Val Val Thr Glu Val Thr Glu Glu Thr Val Asn 
625                 630                 635                 640 


Leu Ala Trp Asp Asn Glu Met Arg Val Thr Glu Tyr Leu Val Val Tyr 
                645                 650                 655     


Thr Pro Thr His Glu Gly Gly Leu Glu Met Gln Phe Arg Val Pro Gly 
            660                 665                 670         


Asp Gln Thr Ser Thr Ile Ile Gln Glu Leu Glu Pro Gly Val Glu Tyr 
        675                 680                 685             


Phe Ile Arg Val Phe Ala Ile Leu Glu Asn Lys Lys Ser Ile Pro Val 
    690                 695                 700                 


Ser Ala Arg Val Ala Thr Tyr Leu Pro Ala Pro Glu Gly Leu Lys Phe 
705                 710                 715                 720 


Lys Ser Ile Lys Glu Thr Ser Val Glu Val Glu Trp Asp Pro Leu Asp 
                725                 730                 735     


Ile Ala Phe Glu Thr Trp Glu Ile Ile Phe Arg Asn Met Asn Lys Glu 
            740                 745                 750         


Asp Glu Gly Glu Ile Thr Lys Ser Leu Arg Arg Pro Glu Thr Ser Tyr 
        755                 760                 765             


Arg Gln Thr Gly Leu Ala Pro Gly Gln Glu Tyr Glu Ile Ser Leu His 
    770                 775                 780                 


Ile Val Lys Asn Asn Thr Arg Gly Pro Gly Leu Lys Arg Val Thr Thr 
785                 790                 795                 800 


Thr Arg Leu Asp Ala Pro Ser Gln Ile Glu Val Lys Asp Val Thr Asp 
                805                 810                 815     


Thr Thr Ala Leu Ile Thr Trp Phe Lys Pro Leu Ala Glu Ile Asp Gly 
            820                 825                 830         


Ile Glu Leu Thr Tyr Gly Ile Lys Asp Val Pro Gly Asp Arg Thr Thr 
        835                 840                 845             


Ile Asp Leu Thr Glu Asp Glu Asn Gln Tyr Ser Ile Gly Asn Leu Lys 
    850                 855                 860                 


Pro Asp Thr Glu Tyr Glu Val Ser Leu Ile Ser Arg Arg Gly Asp Met 
865                 870                 875                 880 


Ser Ser Asn Pro Ala Lys Glu Thr Phe Thr Thr Gly Leu Asp Ala Pro 
                885                 890                 895     


Arg Asn Leu Arg Arg Val Ser Gln Thr Asp Asn Ser Ile Thr Leu Glu 
            900                 905                 910         


Trp Arg Asn Gly Lys Ala Ala Ile Asp Ser Tyr Arg Ile Lys Tyr Ala 
        915                 920                 925             


Pro Ile Ser Gly Gly Asp His Ala Glu Val Asp Val Pro Lys Ser Gln 
    930                 935                 940                 


Gln Ala Thr Thr Lys Thr Thr Leu Thr Gly Leu Arg Pro Gly Thr Glu 
945                 950                 955                 960 


Tyr Gly Ile Gly Val Ser Ala Val Lys Glu Asp Lys Glu Ser Asn Pro 
                965                 970                 975     


Ala Thr Ile Asn Ala Ala Thr Glu Leu Asp Thr Pro Lys Asp Leu Gln 
            980                 985                 990         


Val Ser Glu Thr Ala Glu Thr Ser  Leu Thr Leu Leu Trp  Lys Thr Pro 
        995                 1000                 1005             


Leu Ala  Lys Phe Asp Arg Tyr  Arg Leu Asn Tyr Ser  Leu Pro Thr 
    1010                 1015                 1020             


Gly Gln  Trp Val Gly Val Gln  Leu Pro Arg Asn Thr  Thr Ser Tyr 
    1025                 1030                 1035             


Val Leu  Arg Gly Leu Glu Pro  Gly Gln Glu Tyr Asn  Val Leu Leu 
    1040                 1045                 1050             


Thr Ala  Glu Lys Gly Arg His  Lys Ser Lys Pro Ala  Arg Val Lys 
    1055                 1060                 1065             


Ala Ser  Thr Glu Gln Ala Pro  Glu Leu Glu Asn Leu  Thr Val Thr 
    1070                 1075                 1080             


Glu Val  Gly Trp Asp Gly Leu  Arg Leu Asn Trp Thr  Ala Ala Asp 
    1085                 1090                 1095             


Gln Ala  Tyr Glu His Phe Ile  Ile Gln Val Gln Glu  Ala Asn Lys 
    1100                 1105                 1110             


Val Glu  Ala Ala Arg Asn Leu  Thr Val Pro Gly Ser  Leu Arg Ala 
    1115                 1120                 1125             


Val Asp  Ile Pro Gly Leu Lys  Ala Ala Thr Pro Tyr  Thr Val Ser 
    1130                 1135                 1140             


Ile Tyr  Gly Val Ile Gln Gly  Tyr Arg Thr Pro Val  Leu Ser Ala 
    1145                 1150                 1155             


Glu Ala  Ser Thr Gly Glu Thr  Pro Asn Leu Gly Glu  Val Val Val 
    1160                 1165                 1170             


Ala Glu  Val Gly Trp Asp Ala  Leu Lys Leu Asn Trp  Thr Ala Pro 
    1175                 1180                 1185             


Glu Gly  Ala Tyr Glu Tyr Phe  Phe Ile Gln Val Gln  Glu Ala Asp 
    1190                 1195                 1200             


Thr Val  Glu Ala Ala Gln Asn  Leu Thr Val Pro Gly  Gly Leu Arg 
    1205                 1210                 1215             


Ser Thr  Asp Leu Pro Gly Leu  Lys Ala Ala Thr His  Tyr Thr Ile 
    1220                 1225                 1230             


Thr Ile  Arg Gly Val Thr Gln  Asp Phe Ser Thr Thr  Pro Leu Ser 
    1235                 1240                 1245             


Val Glu  Val Leu Thr Glu Glu  Val Pro Asp Met Gly  Asn Leu Thr 
    1250                 1255                 1260             


Val Thr  Glu Val Ser Trp Asp  Ala Leu Arg Leu Asn  Trp Thr Thr 
    1265                 1270                 1275             


Pro Asp  Gly Thr Tyr Asp Gln  Phe Thr Ile Gln Val  Gln Glu Ala 
    1280                 1285                 1290             


Asp Gln  Val Glu Glu Ala His  Asn Leu Thr Val Pro  Gly Ser Leu 
    1295                 1300                 1305             


Arg Ser  Met Glu Ile Pro Gly  Leu Arg Ala Gly Thr  Pro Tyr Thr 
    1310                 1315                 1320             


Val Thr  Leu His Gly Glu Val  Arg Gly His Ser Thr  Arg Pro Leu 
    1325                 1330                 1335             


Ala Val  Glu Val Val Thr Glu  Asp Leu Pro Gln Leu  Gly Asp Leu 
    1340                 1345                 1350             


Ala Val  Ser Glu Val Gly Trp  Asp Gly Leu Arg Leu  Asn Trp Thr 
    1355                 1360                 1365             


Ala Ala  Asp Asn Ala Tyr Glu  His Phe Val Ile Gln  Val Gln Glu 
    1370                 1375                 1380             


Val Asn  Lys Val Glu Ala Ala  Gln Asn Leu Thr Leu  Pro Gly Ser 
    1385                 1390                 1395             


Leu Arg  Ala Val Asp Ile Pro  Gly Leu Glu Ala Ala  Thr Pro Tyr 
    1400                 1405                 1410             


Arg Val  Ser Ile Tyr Gly Val  Ile Arg Gly Tyr Arg  Thr Pro Val 
    1415                 1420                 1425             


Leu Ser  Ala Glu Ala Ser Thr  Ala Lys Glu Pro Glu  Ile Gly Asn 
    1430                 1435                 1440             


Leu Asn  Val Ser Asp Ile Thr  Pro Glu Ser Phe Asn  Leu Ser Trp 
    1445                 1450                 1455             


Met Ala  Thr Asp Gly Ile Phe  Glu Thr Phe Thr Ile  Glu Ile Ile 
    1460                 1465                 1470             


Asp Ser  Asn Arg Leu Leu Glu  Thr Val Glu Tyr Asn  Ile Ser Gly 
    1475                 1480                 1485             


Ala Glu  Arg Thr Ala His Ile  Ser Gly Leu Pro Pro  Ser Thr Asp 
    1490                 1495                 1500             


Phe Ile  Val Tyr Leu Ser Gly  Leu Ala Pro Ser Ile  Arg Thr Lys 
    1505                 1510                 1515             


Thr Ile  Ser Ala Thr Ala Thr  Thr Glu Ala Leu Pro  Leu Leu Glu 
    1520                 1525                 1530             


Asn Leu  Thr Ile Ser Asp Ile  Asn Pro Tyr Gly Phe  Thr Val Ser 
    1535                 1540                 1545             


Trp Met  Ala Ser Glu Asn Ala  Phe Asp Ser Phe Leu  Val Thr Val 
    1550                 1555                 1560             


Val Asp  Ser Gly Lys Leu Leu  Asp Pro Gln Glu Phe  Thr Leu Ser 
    1565                 1570                 1575             


Gly Thr  Gln Arg Lys Leu Glu  Leu Arg Gly Leu Ile  Thr Gly Ile 
    1580                 1585                 1590             


Gly Tyr  Glu Val Met Val Ser  Gly Phe Thr Gln Gly  His Gln Thr 
    1595                 1600                 1605             


Lys Pro  Leu Arg Ala Glu Ile  Val Thr Glu Ala Glu  Pro Glu Val 
    1610                 1615                 1620             


Asp Asn  Leu Leu Val Ser Asp  Ala Thr Pro Asp Gly  Phe Arg Leu 
    1625                 1630                 1635             


Ser Trp  Thr Ala Asp Glu Gly  Val Phe Asp Asn Phe  Val Leu Lys 
    1640                 1645                 1650             


Ile Arg  Asp Thr Lys Lys Gln  Ser Glu Pro Leu Glu  Ile Thr Leu 
    1655                 1660                 1665             


Leu Ala  Pro Glu Arg Thr Arg  Asp Ile Thr Gly Leu  Arg Glu Ala 
    1670                 1675                 1680             


Thr Glu  Tyr Glu Ile Glu Leu  Tyr Gly Ile Ser Lys  Gly Arg Arg 
    1685                 1690                 1695             


Ser Gln  Thr Val Ser Ala Ile  Ala Thr Thr Ala Met  Gly Ser Pro 
    1700                 1705                 1710             


Lys Glu  Val Ile Phe Ser Asp  Ile Thr Glu Asn Ser  Ala Thr Val 
    1715                 1720                 1725             


Ser Trp  Arg Ala Pro Thr Ala  Gln Val Glu Ser Phe  Arg Ile Thr 
    1730                 1735                 1740             


Tyr Val  Pro Ile Thr Gly Gly  Thr Pro Ser Met Val  Thr Val Asp 
    1745                 1750                 1755             


Gly Thr  Lys Thr Gln Thr Arg  Leu Val Lys Leu Ile  Pro Gly Val 
    1760                 1765                 1770             


Glu Tyr  Leu Val Ser Ile Ile  Ala Met Lys Gly Phe  Glu Glu Ser 
    1775                 1780                 1785             


Glu Pro  Val Ser Gly Ser Phe  Thr Thr Ala Leu Asp  Gly Pro Ser 
    1790                 1795                 1800             


Gly Leu  Val Thr Ala Asn Ile  Thr Asp Ser Glu Ala  Leu Ala Arg 
    1805                 1810                 1815             


Trp Gln  Pro Ala Ile Ala Thr  Val Asp Ser Tyr Val  Ile Ser Tyr 
    1820                 1825                 1830             


Thr Gly  Glu Lys Val Pro Glu  Ile Thr Arg Thr Val  Ser Gly Asn 
    1835                 1840                 1845             


Thr Val  Glu Tyr Ala Leu Thr  Asp Leu Glu Pro Ala  Thr Glu Tyr 
    1850                 1855                 1860             


Thr Leu  Arg Ile Phe Ala Glu  Lys Gly Pro Gln Lys  Ser Ser Thr 
    1865                 1870                 1875             


Ile Thr  Ala Lys Phe Thr Thr  Asp Leu Asp Ser Pro  Arg Asp Leu 
    1880                 1885                 1890             


Thr Ala  Thr Glu Val Gln Ser  Glu Thr Ala Leu Leu  Thr Trp Arg 
    1895                 1900                 1905             


Pro Pro  Arg Ala Ser Val Thr  Gly Tyr Leu Leu Val  Tyr Glu Ser 
    1910                 1915                 1920             


Val Asp  Gly Thr Val Lys Glu  Val Ile Val Gly Pro  Asp Thr Thr 
    1925                 1930                 1935             


Ser Tyr  Ser Leu Ala Asp Leu  Ser Pro Ser Thr His  Tyr Thr Ala 
    1940                 1945                 1950             


Lys Ile  Gln Ala Leu Asn Gly  Pro Leu Arg Ser Asn  Met Ile Gln 
    1955                 1960                 1965             


Thr Ile  Phe Thr Thr Ile Gly  Leu Leu Tyr Pro Phe  Pro Lys Asp 
    1970                 1975                 1980             


Cys Ser  Gln Ala Met Leu Asn  Gly Asp Thr Thr Ser  Gly Leu Tyr 
    1985                 1990                 1995             


Thr Ile  Tyr Leu Asn Gly Asp  Lys Ala Glu Ala Leu  Glu Val Phe 
    2000                 2005                 2010             


Cys Asp  Met Thr Ser Asp Gly  Gly Gly Trp Ile Val  Phe Leu Arg 
    2015                 2020                 2025             


Arg Lys  Asn Gly Arg Glu Asn  Phe Tyr Gln Asn Trp  Lys Ala Tyr 
    2030                 2035                 2040             


Ala Ala  Gly Phe Gly Asp Arg  Arg Glu Glu Phe Trp  Leu Gly Leu 
    2045                 2050                 2055             


Asp Asn  Leu Asn Lys Ile Thr  Ala Gln Gly Gln Tyr  Glu Leu Arg 
    2060                 2065                 2070             


Val Asp  Leu Arg Asp His Gly  Glu Thr Ala Phe Ala  Val Tyr Asp 
    2075                 2080                 2085             


Lys Phe  Ser Val Gly Asp Ala  Lys Thr Arg Tyr Lys  Leu Lys Val 
    2090                 2095                 2100             


Glu Gly  Tyr Ser Gly Thr Ala  Gly Asp Ser Met Ala  Tyr His Asn 
    2105                 2110                 2115             


Gly Arg  Ser Phe Ser Thr Phe  Asp Lys Asp Thr Asp  Ser Ala Ile 
    2120                 2125                 2130             


Thr Asn  Cys Ala Leu Ser Tyr  Lys Gly Ala Phe Trp  Tyr Arg Asn 
    2135                 2140                 2145             


Cys His  Arg Val Asn Leu Met  Gly Arg Tyr Gly Asp  Asn Asn His 
    2150                 2155                 2160             


Ser Gln  Gly Val Asn Trp Phe  His Trp Lys Gly His  Glu His Ser 
    2165                 2170                 2175             


Ile Gln  Phe Ala Glu Met Lys  Leu Arg Pro Ser Asn  Phe Arg Asn 
    2180                 2185                 2190             


Leu Glu  Gly Arg Arg Lys Arg  Ala 
    2195                 2200     


<210>  198
<211>  2322
<212>  PRT
<213>  Homo sapiens

<400>  198

Met Gln Ser Gly Pro Arg Pro Pro Leu Pro Ala Pro Gly Leu Ala Leu 
1               5                   10                  15      


Ala Leu Thr Leu Thr Met Leu Ala Arg Leu Ala Ser Ala Ala Ser Phe 
            20                  25                  30          


Phe Gly Glu Asn His Leu Glu Val Pro Val Ala Thr Ala Leu Thr Asp 
        35                  40                  45              


Ile Asp Leu Gln Leu Gln Phe Ser Thr Ser Gln Pro Glu Ala Leu Leu 
    50                  55                  60                  


Leu Leu Ala Ala Gly Pro Ala Asp His Leu Leu Leu Gln Leu Tyr Ser 
65                  70                  75                  80  


Gly Arg Leu Gln Val Arg Leu Val Leu Gly Gln Glu Glu Leu Arg Leu 
                85                  90                  95      


Gln Thr Pro Ala Glu Thr Leu Leu Ser Asp Ser Ile Pro His Thr Val 
            100                 105                 110         


Val Leu Thr Val Val Glu Gly Trp Ala Thr Leu Ser Val Asp Gly Phe 
        115                 120                 125             


Leu Asn Ala Ser Ser Ala Val Pro Gly Ala Pro Leu Glu Val Pro Tyr 
    130                 135                 140                 


Gly Leu Phe Val Gly Gly Thr Gly Thr Leu Gly Leu Pro Tyr Leu Arg 
145                 150                 155                 160 


Gly Thr Ser Arg Pro Leu Arg Gly Cys Leu His Ala Ala Thr Leu Asn 
                165                 170                 175     


Gly Arg Ser Leu Leu Arg Pro Leu Thr Pro Asp Val His Glu Gly Cys 
            180                 185                 190         


Ala Glu Glu Phe Ser Ala Ser Asp Asp Val Ala Leu Gly Phe Ser Gly 
        195                 200                 205             


Pro His Ser Leu Ala Ala Phe Pro Ala Trp Gly Thr Gln Asp Glu Gly 
    210                 215                 220                 


Thr Leu Glu Phe Thr Leu Thr Thr Gln Ser Arg Gln Ala Pro Leu Ala 
225                 230                 235                 240 


Phe Gln Ala Gly Gly Arg Arg Gly Asp Phe Ile Tyr Val Asp Ile Phe 
                245                 250                 255     


Glu Gly His Leu Arg Ala Val Val Glu Lys Gly Gln Gly Thr Val Leu 
            260                 265                 270         


Leu His Asn Ser Val Pro Val Ala Asp Gly Gln Pro His Glu Val Ser 
        275                 280                 285             


Val His Ile Asn Ala His Arg Leu Glu Ile Ser Val Asp Gln Tyr Pro 
    290                 295                 300                 


Thr His Thr Ser Asn Arg Gly Val Leu Ser Tyr Leu Glu Pro Arg Gly 
305                 310                 315                 320 


Ser Leu Leu Leu Gly Gly Leu Asp Ala Glu Ala Ser Arg His Leu Gln 
                325                 330                 335     


Glu His Arg Leu Gly Leu Thr Pro Glu Ala Thr Asn Ala Ser Leu Leu 
            340                 345                 350         


Gly Cys Met Glu Asp Leu Ser Val Asn Gly Gln Arg Arg Gly Leu Arg 
        355                 360                 365             


Glu Ala Leu Leu Thr Arg Asn Met Ala Ala Gly Cys Arg Leu Glu Glu 
    370                 375                 380                 


Glu Glu Tyr Glu Asp Asp Ala Tyr Gly His Tyr Glu Ala Phe Ser Thr 
385                 390                 395                 400 


Leu Ala Pro Glu Ala Trp Pro Ala Met Glu Leu Pro Glu Pro Cys Val 
                405                 410                 415     


Pro Glu Pro Gly Leu Pro Pro Val Phe Ala Asn Phe Thr Gln Leu Leu 
            420                 425                 430         


Thr Ile Ser Pro Leu Val Val Ala Glu Gly Gly Thr Ala Trp Leu Glu 
        435                 440                 445             


Trp Arg His Val Gln Pro Thr Leu Asp Leu Met Glu Ala Glu Leu Arg 
    450                 455                 460                 


Lys Ser Gln Val Leu Phe Ser Val Thr Arg Gly Ala Arg His Gly Glu 
465                 470                 475                 480 


Leu Glu Leu Asp Ile Pro Gly Ala Gln Ala Arg Lys Met Phe Thr Leu 
                485                 490                 495     


Leu Asp Val Val Asn Arg Lys Ala Arg Phe Ile His Asp Gly Ser Glu 
            500                 505                 510         


Asp Thr Ser Asp Gln Leu Val Leu Glu Val Ser Val Thr Ala Arg Val 
        515                 520                 525             


Pro Met Pro Ser Cys Leu Arg Arg Gly Gln Thr Tyr Leu Leu Pro Ile 
    530                 535                 540                 


Gln Val Asn Pro Val Asn Asp Pro Pro His Ile Ile Phe Pro His Gly 
545                 550                 555                 560 


Ser Leu Met Val Ile Leu Glu His Thr Gln Lys Pro Leu Gly Pro Glu 
                565                 570                 575     


Val Phe Gln Ala Tyr Asp Pro Asp Ser Ala Cys Glu Gly Leu Thr Phe 
            580                 585                 590         


Gln Val Leu Gly Thr Ser Ser Gly Leu Pro Val Glu Arg Arg Asp Gln 
        595                 600                 605             


Pro Gly Glu Pro Ala Thr Glu Phe Ser Cys Arg Glu Leu Glu Ala Gly 
    610                 615                 620                 


Ser Leu Val Tyr Val His Arg Gly Gly Pro Ala Gln Asp Leu Thr Phe 
625                 630                 635                 640 


Arg Val Ser Asp Gly Leu Gln Ala Ser Pro Pro Ala Thr Leu Lys Val 
                645                 650                 655     


Val Ala Ile Arg Pro Ala Ile Gln Ile His Arg Ser Thr Gly Leu Arg 
            660                 665                 670         


Leu Ala Gln Gly Ser Ala Met Pro Ile Leu Pro Ala Asn Leu Ser Val 
        675                 680                 685             


Glu Thr Asn Ala Val Gly Gln Asp Val Ser Val Leu Phe Arg Val Thr 
    690                 695                 700                 


Gly Ala Leu Gln Phe Gly Glu Leu Gln Lys Gln Gly Ala Gly Gly Val 
705                 710                 715                 720 


Glu Gly Ala Glu Trp Trp Ala Thr Gln Ala Phe His Gln Arg Asp Val 
                725                 730                 735     


Glu Gln Gly Arg Val Arg Tyr Leu Ser Thr Asp Pro Gln His His Ala 
            740                 745                 750         


Tyr Asp Thr Val Glu Asn Leu Ala Leu Glu Val Gln Val Gly Gln Glu 
        755                 760                 765             


Ile Leu Ser Asn Leu Ser Phe Pro Val Thr Ile Gln Arg Ala Thr Val 
    770                 775                 780                 


Trp Met Leu Arg Leu Glu Pro Leu His Thr Gln Asn Thr Gln Gln Glu 
785                 790                 795                 800 


Thr Leu Thr Thr Ala His Leu Glu Ala Thr Leu Glu Glu Ala Gly Pro 
                805                 810                 815     


Ser Pro Pro Thr Phe His Tyr Glu Val Val Gln Ala Pro Arg Lys Gly 
            820                 825                 830         


Asn Leu Gln Leu Gln Gly Thr Arg Leu Ser Asp Gly Gln Gly Phe Thr 
        835                 840                 845             


Gln Asp Asp Ile Gln Ala Gly Arg Val Thr Tyr Gly Ala Thr Ala Arg 
    850                 855                 860                 


Ala Ser Glu Ala Val Glu Asp Thr Phe Arg Phe Arg Val Thr Ala Pro 
865                 870                 875                 880 


Pro Tyr Phe Ser Pro Leu Tyr Thr Phe Pro Ile His Ile Gly Gly Asp 
                885                 890                 895     


Pro Asp Ala Pro Val Leu Thr Asn Val Leu Leu Val Val Pro Glu Gly 
            900                 905                 910         


Gly Glu Gly Val Leu Ser Ala Asp His Leu Phe Val Lys Ser Leu Asn 
        915                 920                 925             


Ser Ala Ser Tyr Leu Tyr Glu Val Met Glu Arg Pro Arg His Gly Arg 
    930                 935                 940                 


Leu Ala Trp Arg Gly Thr Gln Asp Lys Thr Thr Met Val Thr Ser Phe 
945                 950                 955                 960 


Thr Asn Glu Asp Leu Leu Arg Gly Arg Leu Val Tyr Gln His Asp Asp 
                965                 970                 975     


Ser Glu Thr Thr Glu Asp Asp Ile Pro Phe Val Ala Thr Arg Gln Gly 
            980                 985                 990         


Glu Ser Ser Gly Asp Met Ala Trp  Glu Glu Val Arg Gly  Val Phe Arg 
        995                 1000                 1005             


Val Ala  Ile Gln Pro Val Asn  Asp His Ala Pro Val  Gln Thr Ile 
    1010                 1015                 1020             


Ser Arg  Ile Phe His Val Ala  Arg Gly Gly Arg Arg  Leu Leu Thr 
    1025                 1030                 1035             


Thr Asp  Asp Val Ala Phe Ser  Asp Ala Asp Ser Gly  Phe Ala Asp 
    1040                 1045                 1050             


Ala Gln  Leu Val Leu Thr Arg  Lys Asp Leu Leu Phe  Gly Ser Ile 
    1055                 1060                 1065             


Val Ala  Val Asp Glu Pro Thr  Arg Pro Ile Tyr Arg  Phe Thr Gln 
    1070                 1075                 1080             


Glu Asp  Leu Arg Lys Arg Arg  Val Leu Phe Val His  Ser Gly Ala 
    1085                 1090                 1095             


Asp Arg  Gly Trp Ile Gln Leu  Gln Val Ser Asp Gly  Gln His Gln 
    1100                 1105                 1110             


Ala Thr  Ala Leu Leu Glu Val  Gln Ala Ser Glu Pro  Tyr Leu Arg 
    1115                 1120                 1125             


Val Ala  Asn Gly Ser Ser Leu  Val Val Pro Gln Gly  Gly Gln Gly 
    1130                 1135                 1140             


Thr Ile  Asp Thr Ala Val Leu  His Leu Asp Thr Asn  Leu Asp Ile 
    1145                 1150                 1155             


Arg Ser  Gly Asp Glu Val His  Tyr His Val Thr Ala  Gly Pro Arg 
    1160                 1165                 1170             


Trp Gly  Gln Leu Val Arg Ala  Gly Gln Pro Ala Thr  Ala Phe Ser 
    1175                 1180                 1185             


Gln Gln  Asp Leu Leu Asp Gly  Ala Val Leu Tyr Ser  His Asn Gly 
    1190                 1195                 1200             


Ser Leu  Ser Pro Arg Asp Thr  Met Ala Phe Ser Val  Glu Ala Gly 
    1205                 1210                 1215             


Pro Val  His Thr Asp Ala Thr  Leu Gln Val Thr Ile  Ala Leu Glu 
    1220                 1225                 1230             


Gly Pro  Leu Ala Pro Leu Lys  Leu Val Arg His Lys  Lys Ile Tyr 
    1235                 1240                 1245             


Val Phe  Gln Gly Glu Ala Ala  Glu Ile Arg Arg Asp  Gln Leu Glu 
    1250                 1255                 1260             


Ala Ala  Gln Glu Ala Val Pro  Pro Ala Asp Ile Val  Phe Ser Val 
    1265                 1270                 1275             


Lys Ser  Pro Pro Ser Ala Gly  Tyr Leu Val Met Val  Ser Arg Gly 
    1280                 1285                 1290             


Ala Leu  Ala Asp Glu Pro Pro  Ser Leu Asp Pro Val  Gln Ser Phe 
    1295                 1300                 1305             


Ser Gln  Glu Ala Val Asp Thr  Gly Arg Val Leu Tyr  Leu His Ser 
    1310                 1315                 1320             


Arg Pro  Glu Ala Trp Ser Asp  Ala Phe Ser Leu Asp  Val Ala Ser 
    1325                 1330                 1335             


Gly Leu  Gly Ala Pro Leu Glu  Gly Val Leu Val Glu  Leu Glu Val 
    1340                 1345                 1350             


Leu Pro  Ala Ala Ile Pro Leu  Glu Ala Gln Asn Phe  Ser Val Pro 
    1355                 1360                 1365             


Glu Gly  Gly Ser Leu Thr Leu  Ala Pro Pro Leu Leu  Arg Val Ser 
    1370                 1375                 1380             


Gly Pro  Tyr Phe Pro Thr Leu  Leu Gly Leu Ser Leu  Gln Val Leu 
    1385                 1390                 1395             


Glu Pro  Pro Gln His Gly Ala  Leu Gln Lys Glu Asp  Gly Pro Gln 
    1400                 1405                 1410             


Ala Arg  Thr Leu Ser Ala Phe  Ser Trp Arg Met Val  Glu Glu Gln 
    1415                 1420                 1425             


Leu Ile  Arg Tyr Val His Asp  Gly Ser Glu Thr Leu  Thr Asp Ser 
    1430                 1435                 1440             


Phe Val  Leu Met Ala Asn Ala  Ser Glu Met Asp Arg  Gln Ser His 
    1445                 1450                 1455             


Pro Val  Ala Phe Thr Val Thr  Val Leu Pro Val Asn  Asp Gln Pro 
    1460                 1465                 1470             


Pro Ile  Leu Thr Thr Asn Thr  Gly Leu Gln Met Trp  Glu Gly Ala 
    1475                 1480                 1485             


Thr Ala  Pro Ile Pro Ala Glu  Ala Leu Arg Ser Thr  Asp Gly Asp 
    1490                 1495                 1500             


Ser Gly  Ser Glu Asp Leu Val  Tyr Thr Ile Glu Gln  Pro Ser Asn 
    1505                 1510                 1515             


Gly Arg  Val Val Leu Arg Gly  Ala Pro Gly Thr Glu  Val Arg Ser 
    1520                 1525                 1530             


Phe Thr  Gln Ala Gln Leu Asp  Gly Gly Leu Val Leu  Phe Ser His 
    1535                 1540                 1545             


Arg Gly  Thr Leu Asp Gly Gly  Phe Arg Phe Arg Leu  Ser Asp Gly 
    1550                 1555                 1560             


Glu His  Thr Ser Pro Gly His  Phe Phe Arg Val Thr  Ala Gln Lys 
    1565                 1570                 1575             


Gln Val  Leu Leu Ser Leu Lys  Gly Ser Gln Thr Leu  Thr Val Cys 
    1580                 1585                 1590             


Pro Gly  Ser Val Gln Pro Leu  Ser Ser Gln Thr Leu  Arg Ala Ser 
    1595                 1600                 1605             


Ser Ser  Ala Gly Thr Asp Pro  Gln Leu Leu Leu Tyr  Arg Val Val 
    1610                 1615                 1620             


Arg Gly  Pro Gln Leu Gly Arg  Leu Phe His Ala Gln  Gln Asp Ser 
    1625                 1630                 1635             


Thr Gly  Glu Ala Leu Val Asn  Phe Thr Gln Ala Glu  Val Tyr Ala 
    1640                 1645                 1650             


Gly Asn  Ile Leu Tyr Glu His  Glu Met Pro Pro Glu  Pro Phe Trp 
    1655                 1660                 1665             


Glu Ala  His Asp Thr Leu Glu  Leu Gln Leu Ser Ser  Pro Pro Ala 
    1670                 1675                 1680             


Arg Asp  Val Ala Ala Thr Leu  Ala Val Ala Val Ser  Phe Glu Ala 
    1685                 1690                 1695             


Ala Cys  Pro Gln Arg Pro Ser  His Leu Trp Lys Asn  Lys Gly Leu 
    1700                 1705                 1710             


Trp Val  Pro Glu Gly Gln Arg  Ala Arg Ile Thr Val  Ala Ala Leu 
    1715                 1720                 1725             


Asp Ala  Ser Asn Leu Leu Ala  Ser Val Pro Ser Pro  Gln Arg Ser 
    1730                 1735                 1740             


Glu His  Asp Val Leu Phe Gln  Val Thr Gln Phe Pro  Ser Arg Gly 
    1745                 1750                 1755             


Gln Leu  Leu Val Ser Glu Glu  Pro Leu His Ala Gly  Gln Pro His 
    1760                 1765                 1770             


Phe Leu  Gln Ser Gln Leu Ala  Ala Gly Gln Leu Val  Tyr Ala His 
    1775                 1780                 1785             


Gly Gly  Gly Gly Thr Gln Gln  Asp Gly Phe His Phe  Arg Ala His 
    1790                 1795                 1800             


Leu Gln  Gly Pro Ala Gly Ala  Ser Val Ala Gly Pro  Gln Thr Ser 
    1805                 1810                 1815             


Glu Ala  Phe Ala Ile Thr Val  Arg Asp Val Asn Glu  Arg Pro Pro 
    1820                 1825                 1830             


Gln Pro  Gln Ala Ser Val Pro  Leu Arg Leu Thr Arg  Gly Ser Arg 
    1835                 1840                 1845             


Ala Pro  Ile Ser Arg Ala Gln  Leu Ser Val Val Asp  Pro Asp Ser 
    1850                 1855                 1860             


Ala Pro  Gly Glu Ile Glu Tyr  Glu Val Gln Arg Ala  Pro His Asn 
    1865                 1870                 1875             


Gly Phe  Leu Ser Leu Val Gly  Gly Gly Leu Gly Pro  Val Thr Arg 
    1880                 1885                 1890             


Phe Thr  Gln Ala Asp Val Asp  Ser Gly Arg Leu Ala  Phe Val Ala 
    1895                 1900                 1905             


Asn Gly  Ser Ser Val Ala Gly  Ile Phe Gln Leu Ser  Met Ser Asp 
    1910                 1915                 1920             


Gly Ala  Ser Pro Pro Leu Pro  Met Ser Leu Ala Val  Asp Ile Leu 
    1925                 1930                 1935             


Pro Ser  Ala Ile Glu Val Gln  Leu Arg Ala Pro Leu  Glu Val Pro 
    1940                 1945                 1950             


Gln Ala  Leu Gly Arg Ser Ser  Leu Ser Gln Gln Gln  Leu Arg Val 
    1955                 1960                 1965             


Val Ser  Asp Arg Glu Glu Pro  Glu Ala Ala Tyr Arg  Leu Ile Gln 
    1970                 1975                 1980             


Gly Pro  Gln Tyr Gly His Leu  Leu Val Gly Gly Arg  Pro Thr Ser 
    1985                 1990                 1995             


Ala Phe  Ser Gln Phe Gln Ile  Asp Gln Gly Glu Val  Val Phe Ala 
    2000                 2005                 2010             


Phe Thr  Asn Phe Ser Ser Ser  His Asp His Phe Arg  Val Leu Ala 
    2015                 2020                 2025             


Leu Ala  Arg Gly Val Asn Ala  Ser Ala Val Val Asn  Val Thr Val 
    2030                 2035                 2040             


Arg Ala  Leu Leu His Val Trp  Ala Gly Gly Pro Trp  Pro Gln Gly 
    2045                 2050                 2055             


Ala Thr  Leu Arg Leu Asp Pro  Thr Val Leu Asp Ala  Gly Glu Leu 
    2060                 2065                 2070             


Ala Asn  Arg Thr Gly Ser Val  Pro Arg Phe Arg Leu  Leu Glu Gly 
    2075                 2080                 2085             


Pro Arg  His Gly Arg Val Val  Arg Val Pro Arg Ala  Arg Thr Glu 
    2090                 2095                 2100             


Pro Gly  Gly Ser Gln Leu Val  Glu Gln Phe Thr Gln  Gln Asp Leu 
    2105                 2110                 2115             


Glu Asp  Gly Arg Leu Gly Leu  Glu Val Gly Arg Pro  Glu Gly Arg 
    2120                 2125                 2130             


Ala Pro  Gly Pro Ala Gly Asp  Ser Leu Thr Leu Glu  Leu Trp Ala 
    2135                 2140                 2145             


Gln Gly  Val Pro Pro Ala Val  Ala Ser Leu Asp Phe  Ala Thr Glu 
    2150                 2155                 2160             


Pro Tyr  Asn Ala Ala Arg Pro  Tyr Ser Val Ala Leu  Leu Ser Val 
    2165                 2170                 2175             


Pro Glu  Ala Ala Arg Thr Glu  Ala Gly Lys Pro Glu  Ser Ser Thr 
    2180                 2185                 2190             


Pro Thr  Gly Glu Pro Gly Pro  Met Ala Ser Ser Pro  Glu Pro Ala 
    2195                 2200                 2205             


Val Ala  Lys Gly Gly Phe Leu  Ser Phe Leu Glu Ala  Asn Met Phe 
    2210                 2215                 2220             


Ser Val  Ile Ile Pro Met Cys  Leu Val Leu Leu Leu  Leu Ala Leu 
    2225                 2230                 2235             


Ile Leu  Pro Leu Leu Phe Tyr  Leu Arg Lys Arg Asn  Lys Thr Gly 
    2240                 2245                 2250             


Lys His  Asp Val Gln Val Leu  Thr Ala Lys Pro Arg  Asn Gly Leu 
    2255                 2260                 2265             


Ala Gly  Asp Thr Glu Thr Phe  Arg Lys Val Glu Pro  Gly Gln Ala 
    2270                 2275                 2280             


Ile Pro  Leu Thr Ala Val Pro  Gly Gln Gly Pro Pro  Pro Gly Gly 
    2285                 2290                 2295             


Gln Pro  Asp Pro Glu Leu Leu  Gln Phe Cys Arg Thr  Pro Asn Pro 
    2300                 2305                 2310             


Ala Leu  Lys Asn Gly Gln Tyr  Trp Val 
    2315                 2320         


<210>  199
<211>  1210
<212>  PRT
<213>  Homo sapiens

<400>  199

Met Arg Pro Ser Gly Thr Ala Gly Ala Ala Leu Leu Ala Leu Leu Ala 
1               5                   10                  15      


Ala Leu Cys Pro Ala Ser Arg Ala Leu Glu Glu Lys Lys Val Cys Gln 
            20                  25                  30          


Gly Thr Ser Asn Lys Leu Thr Gln Leu Gly Thr Phe Glu Asp His Phe 
        35                  40                  45              


Leu Ser Leu Gln Arg Met Phe Asn Asn Cys Glu Val Val Leu Gly Asn 
    50                  55                  60                  


Leu Glu Ile Thr Tyr Val Gln Arg Asn Tyr Asp Leu Ser Phe Leu Lys 
65                  70                  75                  80  


Thr Ile Gln Glu Val Ala Gly Tyr Val Leu Ile Ala Leu Asn Thr Val 
                85                  90                  95      


Glu Arg Ile Pro Leu Glu Asn Leu Gln Ile Ile Arg Gly Asn Met Tyr 
            100                 105                 110         


Tyr Glu Asn Ser Tyr Ala Leu Ala Val Leu Ser Asn Tyr Asp Ala Asn 
        115                 120                 125             


Lys Thr Gly Leu Lys Glu Leu Pro Met Arg Asn Leu Gln Glu Ile Leu 
    130                 135                 140                 


His Gly Ala Val Arg Phe Ser Asn Asn Pro Ala Leu Cys Asn Val Glu 
145                 150                 155                 160 


Ser Ile Gln Trp Arg Asp Ile Val Ser Ser Asp Phe Leu Ser Asn Met 
                165                 170                 175     


Ser Met Asp Phe Gln Asn His Leu Gly Ser Cys Gln Lys Cys Asp Pro 
            180                 185                 190         


Ser Cys Pro Asn Gly Ser Cys Trp Gly Ala Gly Glu Glu Asn Cys Gln 
        195                 200                 205             


Lys Leu Thr Lys Ile Ile Cys Ala Gln Gln Cys Ser Gly Arg Cys Arg 
    210                 215                 220                 


Gly Lys Ser Pro Ser Asp Cys Cys His Asn Gln Cys Ala Ala Gly Cys 
225                 230                 235                 240 


Thr Gly Pro Arg Glu Ser Asp Cys Leu Val Cys Arg Lys Phe Arg Asp 
                245                 250                 255     


Glu Ala Thr Cys Lys Asp Thr Cys Pro Pro Leu Met Leu Tyr Asn Pro 
            260                 265                 270         


Thr Thr Tyr Gln Met Asp Val Asn Pro Glu Gly Lys Tyr Ser Phe Gly 
        275                 280                 285             


Ala Thr Cys Val Lys Lys Cys Pro Arg Asn Tyr Val Val Thr Asp His 
    290                 295                 300                 


Gly Ser Cys Val Arg Ala Cys Gly Ala Asp Ser Tyr Glu Met Glu Glu 
305                 310                 315                 320 


Asp Gly Val Arg Lys Cys Lys Lys Cys Glu Gly Pro Cys Arg Lys Val 
                325                 330                 335     


Cys Asn Gly Ile Gly Ile Gly Glu Phe Lys Asp Ser Leu Ser Ile Asn 
            340                 345                 350         


Ala Thr Asn Ile Lys His Phe Lys Asn Cys Thr Ser Ile Ser Gly Asp 
        355                 360                 365             


Leu His Ile Leu Pro Val Ala Phe Arg Gly Asp Ser Phe Thr His Thr 
    370                 375                 380                 


Pro Pro Leu Asp Pro Gln Glu Leu Asp Ile Leu Lys Thr Val Lys Glu 
385                 390                 395                 400 


Ile Thr Gly Phe Leu Leu Ile Gln Ala Trp Pro Glu Asn Arg Thr Asp 
                405                 410                 415     


Leu His Ala Phe Glu Asn Leu Glu Ile Ile Arg Gly Arg Thr Lys Gln 
            420                 425                 430         


His Gly Gln Phe Ser Leu Ala Val Val Ser Leu Asn Ile Thr Ser Leu 
        435                 440                 445             


Gly Leu Arg Ser Leu Lys Glu Ile Ser Asp Gly Asp Val Ile Ile Ser 
    450                 455                 460                 


Gly Asn Lys Asn Leu Cys Tyr Ala Asn Thr Ile Asn Trp Lys Lys Leu 
465                 470                 475                 480 


Phe Gly Thr Ser Gly Gln Lys Thr Lys Ile Ile Ser Asn Arg Gly Glu 
                485                 490                 495     


Asn Ser Cys Lys Ala Thr Gly Gln Val Cys His Ala Leu Cys Ser Pro 
            500                 505                 510         


Glu Gly Cys Trp Gly Pro Glu Pro Arg Asp Cys Val Ser Cys Arg Asn 
        515                 520                 525             


Val Ser Arg Gly Arg Glu Cys Val Asp Lys Cys Asn Leu Leu Glu Gly 
    530                 535                 540                 


Glu Pro Arg Glu Phe Val Glu Asn Ser Glu Cys Ile Gln Cys His Pro 
545                 550                 555                 560 


Glu Cys Leu Pro Gln Ala Met Asn Ile Thr Cys Thr Gly Arg Gly Pro 
                565                 570                 575     


Asp Asn Cys Ile Gln Cys Ala His Tyr Ile Asp Gly Pro His Cys Val 
            580                 585                 590         


Lys Thr Cys Pro Ala Gly Val Met Gly Glu Asn Asn Thr Leu Val Trp 
        595                 600                 605             


Lys Tyr Ala Asp Ala Gly His Val Cys His Leu Cys His Pro Asn Cys 
    610                 615                 620                 


Thr Tyr Gly Cys Thr Gly Pro Gly Leu Glu Gly Cys Pro Thr Asn Gly 
625                 630                 635                 640 


Pro Lys Ile Pro Ser Ile Ala Thr Gly Met Val Gly Ala Leu Leu Leu 
                645                 650                 655     


Leu Leu Val Val Ala Leu Gly Ile Gly Leu Phe Met Arg Arg Arg His 
            660                 665                 670         


Ile Val Arg Lys Arg Thr Leu Arg Arg Leu Leu Gln Glu Arg Glu Leu 
        675                 680                 685             


Val Glu Pro Leu Thr Pro Ser Gly Glu Ala Pro Asn Gln Ala Leu Leu 
    690                 695                 700                 


Arg Ile Leu Lys Glu Thr Glu Phe Lys Lys Ile Lys Val Leu Gly Ser 
705                 710                 715                 720 


Gly Ala Phe Gly Thr Val Tyr Lys Gly Leu Trp Ile Pro Glu Gly Glu 
                725                 730                 735     


Lys Val Lys Ile Pro Val Ala Ile Lys Glu Leu Arg Glu Ala Thr Ser 
            740                 745                 750         


Pro Lys Ala Asn Lys Glu Ile Leu Asp Glu Ala Tyr Val Met Ala Ser 
        755                 760                 765             


Val Asp Asn Pro His Val Cys Arg Leu Leu Gly Ile Cys Leu Thr Ser 
    770                 775                 780                 


Thr Val Gln Leu Ile Thr Gln Leu Met Pro Phe Gly Cys Leu Leu Asp 
785                 790                 795                 800 


Tyr Val Arg Glu His Lys Asp Asn Ile Gly Ser Gln Tyr Leu Leu Asn 
                805                 810                 815     


Trp Cys Val Gln Ile Ala Lys Gly Met Asn Tyr Leu Glu Asp Arg Arg 
            820                 825                 830         


Leu Val His Arg Asp Leu Ala Ala Arg Asn Val Leu Val Lys Thr Pro 
        835                 840                 845             


Gln His Val Lys Ile Thr Asp Phe Gly Leu Ala Lys Leu Leu Gly Ala 
    850                 855                 860                 


Glu Glu Lys Glu Tyr His Ala Glu Gly Gly Lys Val Pro Ile Lys Trp 
865                 870                 875                 880 


Met Ala Leu Glu Ser Ile Leu His Arg Ile Tyr Thr His Gln Ser Asp 
                885                 890                 895     


Val Trp Ser Tyr Gly Val Thr Val Trp Glu Leu Met Thr Phe Gly Ser 
            900                 905                 910         


Lys Pro Tyr Asp Gly Ile Pro Ala Ser Glu Ile Ser Ser Ile Leu Glu 
        915                 920                 925             


Lys Gly Glu Arg Leu Pro Gln Pro Pro Ile Cys Thr Ile Asp Val Tyr 
    930                 935                 940                 


Met Ile Met Val Lys Cys Trp Met Ile Asp Ala Asp Ser Arg Pro Lys 
945                 950                 955                 960 


Phe Arg Glu Leu Ile Ile Glu Phe Ser Lys Met Ala Arg Asp Pro Gln 
                965                 970                 975     


Arg Tyr Leu Val Ile Gln Gly Asp Glu Arg Met His Leu Pro Ser Pro 
            980                 985                 990         


Thr Asp Ser Asn Phe Tyr Arg Ala  Leu Met Asp Glu Glu  Asp Met Asp 
        995                 1000                 1005             


Asp Val  Val Asp Ala Asp Glu  Tyr Leu Ile Pro Gln  Gln Gly Phe 
    1010                 1015                 1020             


Phe Ser  Ser Pro Ser Thr Ser  Arg Thr Pro Leu Leu  Ser Ser Leu 
    1025                 1030                 1035             


Ser Ala  Thr Ser Asn Asn Ser  Thr Val Ala Cys Ile  Asp Arg Asn 
    1040                 1045                 1050             


Gly Leu  Gln Ser Cys Pro Ile  Lys Glu Asp Ser Phe  Leu Gln Arg 
    1055                 1060                 1065             


Tyr Ser  Ser Asp Pro Thr Gly  Ala Leu Thr Glu Asp  Ser Ile Asp 
    1070                 1075                 1080             


Asp Thr  Phe Leu Pro Val Pro  Glu Tyr Ile Asn Gln  Ser Val Pro 
    1085                 1090                 1095             


Lys Arg  Pro Ala Gly Ser Val  Gln Asn Pro Val Tyr  His Asn Gln 
    1100                 1105                 1110             


Pro Leu  Asn Pro Ala Pro Ser  Arg Asp Pro His Tyr  Gln Asp Pro 
    1115                 1120                 1125             


His Ser  Thr Ala Val Gly Asn  Pro Glu Tyr Leu Asn  Thr Val Gln 
    1130                 1135                 1140             


Pro Thr  Cys Val Asn Ser Thr  Phe Asp Ser Pro Ala  His Trp Ala 
    1145                 1150                 1155             


Gln Lys  Gly Ser His Gln Ile  Ser Leu Asp Asn Pro  Asp Tyr Gln 
    1160                 1165                 1170             


Gln Asp  Phe Phe Pro Lys Glu  Ala Lys Pro Asn Gly  Ile Phe Lys 
    1175                 1180                 1185             


Gly Ser  Thr Ala Glu Asn Ala  Glu Tyr Leu Arg Val  Ala Pro Gln 
    1190                 1195                 1200             


Ser Ser  Glu Phe Ile Gly Ala  
    1205                 1210 


<210>  200
<211>  556
<212>  PRT
<213>  Homo sapiens

<400>  200

Met Pro Pro Pro Arg Leu Leu Phe Phe Leu Leu Phe Leu Thr Pro Met 
1               5                   10                  15      


Glu Val Arg Pro Glu Glu Pro Leu Val Val Lys Val Glu Glu Gly Asp 
            20                  25                  30          


Asn Ala Val Leu Gln Cys Leu Lys Gly Thr Ser Asp Gly Pro Thr Gln 
        35                  40                  45              


Gln Leu Thr Trp Ser Arg Glu Ser Pro Leu Lys Pro Phe Leu Lys Leu 
    50                  55                  60                  


Ser Leu Gly Leu Pro Gly Leu Gly Ile His Met Arg Pro Leu Ala Ile 
65                  70                  75                  80  


Trp Leu Phe Ile Phe Asn Val Ser Gln Gln Met Gly Gly Phe Tyr Leu 
                85                  90                  95      


Cys Gln Pro Gly Pro Pro Ser Glu Lys Ala Trp Gln Pro Gly Trp Thr 
            100                 105                 110         


Val Asn Val Glu Gly Ser Gly Glu Leu Phe Arg Trp Asn Val Ser Asp 
        115                 120                 125             


Leu Gly Gly Leu Gly Cys Gly Leu Lys Asn Arg Ser Ser Glu Gly Pro 
    130                 135                 140                 


Ser Ser Pro Ser Gly Lys Leu Met Ser Pro Lys Leu Tyr Val Trp Ala 
145                 150                 155                 160 


Lys Asp Arg Pro Glu Ile Trp Glu Gly Glu Pro Pro Cys Leu Pro Pro 
                165                 170                 175     


Arg Asp Ser Leu Asn Gln Ser Leu Ser Gln Asp Leu Thr Met Ala Pro 
            180                 185                 190         


Gly Ser Thr Leu Trp Leu Ser Cys Gly Val Pro Pro Asp Ser Val Ser 
        195                 200                 205             


Arg Gly Pro Leu Ser Trp Thr His Val His Pro Lys Gly Pro Lys Ser 
    210                 215                 220                 


Leu Leu Ser Leu Glu Leu Lys Asp Asp Arg Pro Ala Arg Asp Met Trp 
225                 230                 235                 240 


Val Met Glu Thr Gly Leu Leu Leu Pro Arg Ala Thr Ala Gln Asp Ala 
                245                 250                 255     


Gly Lys Tyr Tyr Cys His Arg Gly Asn Leu Thr Met Ser Phe His Leu 
            260                 265                 270         


Glu Ile Thr Ala Arg Pro Val Leu Trp His Trp Leu Leu Arg Thr Gly 
        275                 280                 285             


Gly Trp Lys Val Ser Ala Val Thr Leu Ala Tyr Leu Ile Phe Cys Leu 
    290                 295                 300                 


Cys Ser Leu Val Gly Ile Leu His Leu Gln Arg Ala Leu Val Leu Arg 
305                 310                 315                 320 


Arg Lys Arg Lys Arg Met Thr Asp Pro Thr Arg Arg Phe Phe Lys Val 
                325                 330                 335     


Thr Pro Pro Pro Gly Ser Gly Pro Gln Asn Gln Tyr Gly Asn Val Leu 
            340                 345                 350         


Ser Leu Pro Thr Pro Thr Ser Gly Leu Gly Arg Ala Gln Arg Trp Ala 
        355                 360                 365             


Ala Gly Leu Gly Gly Thr Ala Pro Ser Tyr Gly Asn Pro Ser Ser Asp 
    370                 375                 380                 


Val Gln Ala Asp Gly Ala Leu Gly Ser Arg Ser Pro Pro Gly Val Gly 
385                 390                 395                 400 


Pro Glu Glu Glu Glu Gly Glu Gly Tyr Glu Glu Pro Asp Ser Glu Glu 
                405                 410                 415     


Asp Ser Glu Phe Tyr Glu Asn Asp Ser Asn Leu Gly Gln Asp Gln Leu 
            420                 425                 430         


Ser Gln Asp Gly Ser Gly Tyr Glu Asn Pro Glu Asp Glu Pro Leu Gly 
        435                 440                 445             


Pro Glu Asp Glu Asp Ser Phe Ser Asn Ala Glu Ser Tyr Glu Asn Glu 
    450                 455                 460                 


Asp Glu Glu Leu Thr Gln Pro Val Ala Arg Thr Met Asp Phe Leu Ser 
465                 470                 475                 480 


Pro His Gly Ser Ala Trp Asp Pro Ser Arg Glu Ala Thr Ser Leu Gly 
                485                 490                 495     


Ser Gln Ser Tyr Glu Asp Met Arg Gly Ile Leu Tyr Ala Ala Pro Gln 
            500                 505                 510         


Leu Arg Ser Ile Arg Gly Gln Pro Gly Pro Asn His Glu Glu Asp Ala 
        515                 520                 525             


Asp Ser Tyr Glu Asn Met Asp Asn Pro Asp Gly Pro Asp Pro Ala Trp 
    530                 535                 540                 


Gly Gly Gly Gly Arg Met Gly Thr Trp Ser Thr Arg 
545                 550                 555     


<210>  201
<211>  297
<212>  PRT
<213>  Homo sapiens

<400>  201

Met Thr Thr Pro Arg Asn Ser Val Asn Gly Thr Phe Pro Ala Glu Pro 
1               5                   10                  15      


Met Lys Gly Pro Ile Ala Met Gln Ser Gly Pro Lys Pro Leu Phe Arg 
            20                  25                  30          


Arg Met Ser Ser Leu Val Gly Pro Thr Gln Ser Phe Phe Met Arg Glu 
        35                  40                  45              


Ser Lys Thr Leu Gly Ala Val Gln Ile Met Asn Gly Leu Phe His Ile 
    50                  55                  60                  


Ala Leu Gly Gly Leu Leu Met Ile Pro Ala Gly Ile Tyr Ala Pro Ile 
65                  70                  75                  80  


Cys Val Thr Val Trp Tyr Pro Leu Trp Gly Gly Ile Met Tyr Ile Ile 
                85                  90                  95      


Ser Gly Ser Leu Leu Ala Ala Thr Glu Lys Asn Ser Arg Lys Cys Leu 
            100                 105                 110         


Val Lys Gly Lys Met Ile Met Asn Ser Leu Ser Leu Phe Ala Ala Ile 
        115                 120                 125             


Ser Gly Met Ile Leu Ser Ile Met Asp Ile Leu Asn Ile Lys Ile Ser 
    130                 135                 140                 


His Phe Leu Lys Met Glu Ser Leu Asn Phe Ile Arg Ala His Thr Pro 
145                 150                 155                 160 


Tyr Ile Asn Ile Tyr Asn Cys Glu Pro Ala Asn Pro Ser Glu Lys Asn 
                165                 170                 175     


Ser Pro Ser Thr Gln Tyr Cys Tyr Ser Ile Gln Ser Leu Phe Leu Gly 
            180                 185                 190         


Ile Leu Ser Val Met Leu Ile Phe Ala Phe Phe Gln Glu Leu Val Ile 
        195                 200                 205             


Ala Gly Ile Val Glu Asn Glu Trp Lys Arg Thr Cys Ser Arg Pro Lys 
    210                 215                 220                 


Ser Asn Ile Val Leu Leu Ser Ala Glu Glu Lys Lys Glu Gln Thr Ile 
225                 230                 235                 240 


Glu Ile Lys Glu Glu Val Val Gly Leu Thr Glu Thr Ser Ser Gln Pro 
                245                 250                 255     


Lys Asn Glu Glu Asp Ile Glu Ile Ile Pro Ile Gln Glu Glu Glu Glu 
            260                 265                 270         


Glu Glu Thr Glu Thr Asn Phe Pro Glu Pro Pro Gln Asp Gln Glu Ser 
        275                 280                 285             


Ser Pro Ile Glu Asn Asp Ser Ser Pro 
    290                 295         


<210>  202
<211>  364
<212>  PRT
<213>  Homo sapiens

<400>  202

Met Pro Leu Leu Leu Leu Leu Pro Leu Leu Trp Ala Gly Ala Leu Ala 
1               5                   10                  15      


Met Asp Pro Asn Phe Trp Leu Gln Val Gln Glu Ser Val Thr Val Gln 
            20                  25                  30          


Glu Gly Leu Cys Val Leu Val Pro Cys Thr Phe Phe His Pro Ile Pro 
        35                  40                  45              


Tyr Tyr Asp Lys Asn Ser Pro Val His Gly Tyr Trp Phe Arg Glu Gly 
    50                  55                  60                  


Ala Ile Ile Ser Arg Asp Ser Pro Val Ala Thr Asn Lys Leu Asp Gln 
65                  70                  75                  80  


Glu Val Gln Glu Glu Thr Gln Gly Arg Phe Arg Leu Leu Gly Asp Pro 
                85                  90                  95      


Ser Arg Asn Asn Cys Ser Leu Ser Ile Val Asp Ala Arg Arg Arg Asp 
            100                 105                 110         


Asn Gly Ser Tyr Phe Phe Arg Met Glu Arg Gly Ser Thr Lys Tyr Ser 
        115                 120                 125             


Tyr Lys Ser Pro Gln Leu Ser Val His Val Thr Asp Leu Thr His Arg 
    130                 135                 140                 


Pro Lys Ile Leu Ile Pro Gly Thr Leu Glu Pro Gly His Ser Lys Asn 
145                 150                 155                 160 


Leu Thr Cys Ser Val Ser Trp Ala Cys Glu Gln Gly Thr Pro Pro Ile 
                165                 170                 175     


Phe Ser Trp Leu Ser Ala Ala Pro Thr Ser Leu Gly Pro Arg Thr Thr 
            180                 185                 190         


His Ser Ser Val Leu Ile Ile Thr Pro Arg Pro Gln Asp His Gly Thr 
        195                 200                 205             


Asn Leu Thr Cys Gln Val Lys Phe Ala Gly Ala Gly Val Thr Thr Glu 
    210                 215                 220                 


Arg Thr Ile Gln Leu Asn Val Thr Tyr Val Pro Gln Asn Pro Thr Thr 
225                 230                 235                 240 


Gly Ile Phe Pro Gly Asp Gly Ser Gly Lys Gln Glu Thr Arg Ala Gly 
                245                 250                 255     


Val Val His Gly Ala Ile Gly Gly Ala Gly Val Thr Ala Leu Leu Ala 
            260                 265                 270         


Leu Cys Leu Cys Leu Ile Phe Phe Ile Val Lys Thr His Arg Arg Lys 
        275                 280                 285             


Ala Ala Arg Thr Ala Val Gly Arg Asn Asp Thr His Pro Thr Thr Gly 
    290                 295                 300                 


Ser Ala Ser Pro Lys His Gln Lys Lys Ser Lys Leu His Gly Pro Thr 
305                 310                 315                 320 


Glu Thr Ser Ser Cys Ser Gly Ala Ala Pro Thr Val Glu Met Asp Glu 
                325                 330                 335     


Glu Leu His Tyr Ala Ser Leu Asn Phe His Gly Met Asn Pro Ser Lys 
            340                 345                 350         


Asp Thr Ser Thr Glu Tyr Ser Glu Val Arg Thr Gln 
        355                 360                 


<210>  203
<211>  205
<212>  PRT
<213>  Homo sapiens

<400>  203

Met Thr Pro Pro Glu Arg Leu Phe Leu Pro Arg Val Cys Gly Thr Thr 
1               5                   10                  15      


Leu His Leu Leu Leu Leu Gly Leu Leu Leu Val Leu Leu Pro Gly Ala 
            20                  25                  30          


Gln Gly Leu Pro Gly Val Gly Leu Thr Pro Ser Ala Ala Gln Thr Ala 
        35                  40                  45              


Arg Gln His Pro Lys Met His Leu Ala His Ser Thr Leu Lys Pro Ala 
    50                  55                  60                  


Ala His Leu Ile Gly Asp Pro Ser Lys Gln Asn Ser Leu Leu Trp Arg 
65                  70                  75                  80  


Ala Asn Thr Asp Arg Ala Phe Leu Gln Asp Gly Phe Ser Leu Ser Asn 
                85                  90                  95      


Asn Ser Leu Leu Val Pro Thr Ser Gly Ile Tyr Phe Val Tyr Ser Gln 
            100                 105                 110         


Val Val Phe Ser Gly Lys Ala Tyr Ser Pro Lys Ala Thr Ser Ser Pro 
        115                 120                 125             


Leu Tyr Leu Ala His Glu Val Gln Leu Phe Ser Ser Gln Tyr Pro Phe 
    130                 135                 140                 


His Val Pro Leu Leu Ser Ser Gln Lys Met Val Tyr Pro Gly Leu Gln 
145                 150                 155                 160 


Glu Pro Trp Leu His Ser Met Tyr His Gly Ala Ala Phe Gln Leu Thr 
                165                 170                 175     


Gln Gly Asp Gln Leu Ser Thr His Thr Asp Gly Ile Pro His Leu Val 
            180                 185                 190         


Leu Ser Pro Ser Thr Val Phe Phe Gly Ala Phe Ala Leu 
        195                 200                 205 


<210>  204
<211>  233
<212>  PRT
<213>  Homo sapiens

<400>  204

Met Ser Thr Glu Ser Met Ile Arg Asp Val Glu Leu Ala Glu Glu Ala 
1               5                   10                  15      


Leu Pro Lys Lys Thr Gly Gly Pro Gln Gly Ser Arg Arg Cys Leu Phe 
            20                  25                  30          


Leu Ser Leu Phe Ser Phe Leu Ile Val Ala Gly Ala Thr Thr Leu Phe 
        35                  40                  45              


Cys Leu Leu His Phe Gly Val Ile Gly Pro Gln Arg Glu Glu Phe Pro 
    50                  55                  60                  


Arg Asp Leu Ser Leu Ile Ser Pro Leu Ala Gln Ala Val Arg Ser Ser 
65                  70                  75                  80  


Ser Arg Thr Pro Ser Asp Lys Pro Val Ala His Val Val Ala Asn Pro 
                85                  90                  95      


Gln Ala Glu Gly Gln Leu Gln Trp Leu Asn Arg Arg Ala Asn Ala Leu 
            100                 105                 110         


Leu Ala Asn Gly Val Glu Leu Arg Asp Asn Gln Leu Val Val Pro Ser 
        115                 120                 125             


Glu Gly Leu Tyr Leu Ile Tyr Ser Gln Val Leu Phe Lys Gly Gln Gly 
    130                 135                 140                 


Cys Pro Ser Thr His Val Leu Leu Thr His Thr Ile Ser Arg Ile Ala 
145                 150                 155                 160 


Val Ser Tyr Gln Thr Lys Val Asn Leu Leu Ser Ala Ile Lys Ser Pro 
                165                 170                 175     


Cys Gln Arg Glu Thr Pro Glu Gly Ala Glu Ala Lys Pro Trp Tyr Glu 
            180                 185                 190         


Pro Ile Tyr Leu Gly Gly Val Phe Gln Leu Glu Lys Gly Asp Arg Leu 
        195                 200                 205             


Ser Ala Glu Ile Asn Arg Pro Asp Tyr Leu Asp Phe Ala Glu Ser Gly 
    210                 215                 220                 


Gln Val Tyr Phe Gly Ile Ile Ala Leu 
225                 230             


<210>  205
<211>  244
<212>  PRT
<213>  Homo sapiens

<400>  205

Met Gly Ala Leu Gly Leu Glu Gly Arg Gly Gly Arg Leu Gln Gly Arg 
1               5                   10                  15      


Gly Ser Leu Leu Leu Ala Val Ala Gly Ala Thr Ser Leu Val Thr Leu 
            20                  25                  30          


Leu Leu Ala Val Pro Ile Thr Val Leu Ala Val Leu Ala Leu Val Pro 
        35                  40                  45              


Gln Asp Gln Gly Gly Leu Val Thr Glu Thr Ala Asp Pro Gly Ala Gln 
    50                  55                  60                  


Ala Gln Gln Gly Leu Gly Phe Gln Lys Leu Pro Glu Glu Glu Pro Glu 
65                  70                  75                  80  


Thr Asp Leu Ser Pro Gly Leu Pro Ala Ala His Leu Ile Gly Ala Pro 
                85                  90                  95      


Leu Lys Gly Gln Gly Leu Gly Trp Glu Thr Thr Lys Glu Gln Ala Phe 
            100                 105                 110         


Leu Thr Ser Gly Thr Gln Phe Ser Asp Ala Glu Gly Leu Ala Leu Pro 
        115                 120                 125             


Gln Asp Gly Leu Tyr Tyr Leu Tyr Cys Leu Val Gly Tyr Arg Gly Arg 
    130                 135                 140                 


Ala Pro Pro Gly Gly Gly Asp Pro Gln Gly Arg Ser Val Thr Leu Arg 
145                 150                 155                 160 


Ser Ser Leu Tyr Arg Ala Gly Gly Ala Tyr Gly Pro Gly Thr Pro Glu 
                165                 170                 175     


Leu Leu Leu Glu Gly Ala Glu Thr Val Thr Pro Val Leu Asp Pro Ala 
            180                 185                 190         


Arg Arg Gln Gly Tyr Gly Pro Leu Trp Tyr Thr Ser Val Gly Phe Gly 
        195                 200                 205             


Gly Leu Val Gln Leu Arg Arg Gly Glu Arg Val Tyr Val Asn Ile Ser 
    210                 215                 220                 


His Pro Asp Met Val Asp Phe Ala Arg Gly Lys Thr Phe Phe Gly Ala 
225                 230                 235                 240 


Val Met Val Gly 
                


<210>  206
<211>  183
<212>  PRT
<213>  Homo sapiens

<400>  206

Met Glu Arg Val Gln Pro Leu Glu Glu Asn Val Gly Asn Ala Ala Arg 
1               5                   10                  15      


Pro Arg Phe Glu Arg Asn Lys Leu Leu Leu Val Ala Ser Val Ile Gln 
            20                  25                  30          


Gly Leu Gly Leu Leu Leu Cys Phe Thr Tyr Ile Cys Leu His Phe Ser 
        35                  40                  45              


Ala Leu Gln Val Ser His Arg Tyr Pro Arg Ile Gln Ser Ile Lys Val 
    50                  55                  60                  


Gln Phe Thr Glu Tyr Lys Lys Glu Lys Gly Phe Ile Leu Thr Ser Gln 
65                  70                  75                  80  


Lys Glu Asp Glu Ile Met Lys Val Gln Asn Asn Ser Val Ile Ile Asn 
                85                  90                  95      


Cys Asp Gly Phe Tyr Leu Ile Ser Leu Lys Gly Tyr Phe Ser Gln Glu 
            100                 105                 110         


Val Asn Ile Ser Leu His Tyr Gln Lys Asp Glu Glu Pro Leu Phe Gln 
        115                 120                 125             


Leu Lys Lys Val Arg Ser Val Asn Ser Leu Met Val Ala Ser Leu Thr 
    130                 135                 140                 


Tyr Lys Asp Lys Val Tyr Leu Asn Val Thr Thr Asp Asn Thr Ser Leu 
145                 150                 155                 160 


Asp Asp Phe His Val Asn Gly Gly Glu Leu Ile Leu Ile His Gln Asn 
                165                 170                 175     


Pro Gly Glu Phe Cys Val Leu 
            180             


<210>  207
<211>  261
<212>  PRT
<213>  Homo sapiens

<400>  207

Met Ile Glu Thr Tyr Asn Gln Thr Ser Pro Arg Ser Ala Ala Thr Gly 
1               5                   10                  15      


Leu Pro Ile Ser Met Lys Ile Phe Met Tyr Leu Leu Thr Val Phe Leu 
            20                  25                  30          


Ile Thr Gln Met Ile Gly Ser Ala Leu Phe Ala Val Tyr Leu His Arg 
        35                  40                  45              


Arg Leu Asp Lys Ile Glu Asp Glu Arg Asn Leu His Glu Asp Phe Val 
    50                  55                  60                  


Phe Met Lys Thr Ile Gln Arg Cys Asn Thr Gly Glu Arg Ser Leu Ser 
65                  70                  75                  80  


Leu Leu Asn Cys Glu Glu Ile Lys Ser Gln Phe Glu Gly Phe Val Lys 
                85                  90                  95      


Asp Ile Met Leu Asn Lys Glu Glu Thr Lys Lys Glu Asn Ser Phe Glu 
            100                 105                 110         


Met Gln Lys Gly Asp Gln Asn Pro Gln Ile Ala Ala His Val Ile Ser 
        115                 120                 125             


Glu Ala Ser Ser Lys Thr Thr Ser Val Leu Gln Trp Ala Glu Lys Gly 
    130                 135                 140                 


Tyr Tyr Thr Met Ser Asn Asn Leu Val Thr Leu Glu Asn Gly Lys Gln 
145                 150                 155                 160 


Leu Thr Val Lys Arg Gln Gly Leu Tyr Tyr Ile Tyr Ala Gln Val Thr 
                165                 170                 175     


Phe Cys Ser Asn Arg Glu Ala Ser Ser Gln Ala Pro Phe Ile Ala Ser 
            180                 185                 190         


Leu Cys Leu Lys Ser Pro Gly Arg Phe Glu Arg Ile Leu Leu Arg Ala 
        195                 200                 205             


Ala Asn Thr His Ser Ser Ala Lys Pro Cys Gly Gln Gln Ser Ile His 
    210                 215                 220                 


Leu Gly Gly Val Phe Glu Leu Gln Pro Gly Ala Ser Val Phe Val Asn 
225                 230                 235                 240 


Val Thr Asp Pro Ser Gln Val Ser His Gly Thr Gly Phe Thr Ser Phe 
                245                 250                 255     


Gly Leu Leu Lys Leu 
            260     


<210>  208
<211>  281
<212>  PRT
<213>  Homo sapiens

<400>  208

Met Gln Gln Pro Phe Asn Tyr Pro Tyr Pro Gln Ile Tyr Trp Val Asp 
1               5                   10                  15      


Ser Ser Ala Ser Ser Pro Trp Ala Pro Pro Gly Thr Val Leu Pro Cys 
            20                  25                  30          


Pro Thr Ser Val Pro Arg Arg Pro Gly Gln Arg Arg Pro Pro Pro Pro 
        35                  40                  45              


Pro Pro Pro Pro Pro Leu Pro Pro Pro Pro Pro Pro Pro Pro Leu Pro 
    50                  55                  60                  


Pro Leu Pro Leu Pro Pro Leu Lys Lys Arg Gly Asn His Ser Thr Gly 
65                  70                  75                  80  


Leu Cys Leu Leu Val Met Phe Phe Met Val Leu Val Ala Leu Val Gly 
                85                  90                  95      


Leu Gly Leu Gly Met Phe Gln Leu Phe His Leu Gln Lys Glu Leu Ala 
            100                 105                 110         


Glu Leu Arg Glu Ser Thr Ser Gln Met His Thr Ala Ser Ser Leu Glu 
        115                 120                 125             


Lys Gln Ile Gly His Pro Ser Pro Pro Pro Glu Lys Lys Glu Leu Arg 
    130                 135                 140                 


Lys Val Ala His Leu Thr Gly Lys Ser Asn Ser Arg Ser Met Pro Leu 
145                 150                 155                 160 


Glu Trp Glu Asp Thr Tyr Gly Ile Val Leu Leu Ser Gly Val Lys Tyr 
                165                 170                 175     


Lys Lys Gly Gly Leu Val Ile Asn Glu Thr Gly Leu Tyr Phe Val Tyr 
            180                 185                 190         


Ser Lys Val Tyr Phe Arg Gly Gln Ser Cys Asn Asn Leu Pro Leu Ser 
        195                 200                 205             


His Lys Val Tyr Met Arg Asn Ser Lys Tyr Pro Gln Asp Leu Val Met 
    210                 215                 220                 


Met Glu Gly Lys Met Met Ser Tyr Cys Thr Thr Gly Gln Met Trp Ala 
225                 230                 235                 240 


Arg Ser Ser Tyr Leu Gly Ala Val Phe Asn Leu Thr Ser Ala Asp His 
                245                 250                 255     


Leu Tyr Val Asn Val Ser Glu Leu Ser Leu Val Asn Phe Glu Glu Ser 
            260                 265                 270         


Gln Thr Phe Phe Gly Leu Tyr Lys Leu 
        275                 280     


<210>  209
<211>  193
<212>  PRT
<213>  Homo sapiens

<400>  209

Met Pro Glu Glu Gly Ser Gly Cys Ser Val Arg Arg Arg Pro Tyr Gly 
1               5                   10                  15      


Cys Val Leu Arg Ala Ala Leu Val Pro Leu Val Ala Gly Leu Val Ile 
            20                  25                  30          


Cys Leu Val Val Cys Ile Gln Arg Phe Ala Gln Ala Gln Gln Gln Leu 
        35                  40                  45              


Pro Leu Glu Ser Leu Gly Trp Asp Val Ala Glu Leu Gln Leu Asn His 
    50                  55                  60                  


Thr Gly Pro Gln Gln Asp Pro Arg Leu Tyr Trp Gln Gly Gly Pro Ala 
65                  70                  75                  80  


Leu Gly Arg Ser Phe Leu His Gly Pro Glu Leu Asp Lys Gly Gln Leu 
                85                  90                  95      


Arg Ile His Arg Asp Gly Ile Tyr Met Val His Ile Gln Val Thr Leu 
            100                 105                 110         


Ala Ile Cys Ser Ser Thr Thr Ala Ser Arg His His Pro Thr Thr Leu 
        115                 120                 125             


Ala Val Gly Ile Cys Ser Pro Ala Ser Arg Ser Ile Ser Leu Leu Arg 
    130                 135                 140                 


Leu Ser Phe His Gln Gly Cys Thr Ile Ala Ser Gln Arg Leu Thr Pro 
145                 150                 155                 160 


Leu Ala Arg Gly Asp Thr Leu Cys Thr Asn Leu Thr Gly Thr Leu Leu 
                165                 170                 175     


Pro Ser Arg Asn Thr Asp Glu Thr Phe Phe Gly Val Gln Trp Val Arg 
            180                 185                 190         


Pro 
    


<210>  210
<211>  234
<212>  PRT
<213>  Homo sapiens

<400>  210

Met Asp Pro Gly Leu Gln Gln Ala Leu Asn Gly Met Ala Pro Pro Gly 
1               5                   10                  15      


Asp Thr Ala Met His Val Pro Ala Gly Ser Val Ala Ser His Leu Gly 
            20                  25                  30          


Thr Thr Ser Arg Ser Tyr Phe Tyr Leu Thr Thr Ala Thr Leu Ala Leu 
        35                  40                  45              


Cys Leu Val Phe Thr Val Ala Thr Ile Met Val Leu Val Val Gln Arg 
    50                  55                  60                  


Thr Asp Ser Ile Pro Asn Ser Pro Asp Asn Val Pro Leu Lys Gly Gly 
65                  70                  75                  80  


Asn Cys Ser Glu Asp Leu Leu Cys Ile Leu Lys Arg Ala Pro Phe Lys 
                85                  90                  95      


Lys Ser Trp Ala Tyr Leu Gln Val Ala Lys His Leu Asn Lys Thr Lys 
            100                 105                 110         


Leu Ser Trp Asn Lys Asp Gly Ile Leu His Gly Val Arg Tyr Gln Asp 
        115                 120                 125             


Gly Asn Leu Val Ile Gln Phe Pro Gly Leu Tyr Phe Ile Ile Cys Gln 
    130                 135                 140                 


Leu Gln Phe Leu Val Gln Cys Pro Asn Asn Ser Val Asp Leu Lys Leu 
145                 150                 155                 160 


Glu Leu Leu Ile Asn Lys His Ile Lys Lys Gln Ala Leu Val Thr Val 
                165                 170                 175     


Cys Glu Ser Gly Met Gln Thr Lys His Val Tyr Gln Asn Leu Ser Gln 
            180                 185                 190         


Phe Leu Leu Asp Tyr Leu Gln Val Asn Thr Thr Ile Ser Val Asn Val 
        195                 200                 205             


Asp Thr Phe Gln Tyr Ile Asp Thr Ser Thr Phe Pro Leu Glu Asn Val 
    210                 215                 220                 


Leu Ser Ile Phe Leu Tyr Ser Asn Ser Asp 
225                 230                 


<210>  211
<211>  254
<212>  PRT
<213>  Homo sapiens

<400>  211

Met Glu Tyr Ala Ser Asp Ala Ser Leu Asp Pro Glu Ala Pro Trp Pro 
1               5                   10                  15      


Pro Ala Pro Arg Ala Arg Ala Cys Arg Val Leu Pro Trp Ala Leu Val 
            20                  25                  30          


Ala Gly Leu Leu Leu Leu Leu Leu Leu Ala Ala Ala Cys Ala Val Phe 
        35                  40                  45              


Leu Ala Cys Pro Trp Ala Val Ser Gly Ala Arg Ala Ser Pro Gly Ser 
    50                  55                  60                  


Ala Ala Ser Pro Arg Leu Arg Glu Gly Pro Glu Leu Ser Pro Asp Asp 
65                  70                  75                  80  


Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu Val 
                85                  90                  95      


Ala Gln Asn Val Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp 
            100                 105                 110         


Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu 
        115                 120                 125             


Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe 
    130                 135                 140                 


Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser 
145                 150                 155                 160 


Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala 
                165                 170                 175     


Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala 
            180                 185                 190         


Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala 
        195                 200                 205             


Gly Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg His 
    210                 215                 220                 


Ala Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val 
225                 230                 235                 240 


Thr Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu 
                245                 250                 


<210>  212
<211>  281
<212>  PRT
<213>  Homo sapiens

<400>  212

Met Ala Met Met Glu Val Gln Gly Gly Pro Ser Leu Gly Gln Thr Cys 
1               5                   10                  15      


Val Leu Ile Val Ile Phe Thr Val Leu Leu Gln Ser Leu Cys Val Ala 
            20                  25                  30          


Val Thr Tyr Val Tyr Phe Thr Asn Glu Leu Lys Gln Met Gln Asp Lys 
        35                  40                  45              


Tyr Ser Lys Ser Gly Ile Ala Cys Phe Leu Lys Glu Asp Asp Ser Tyr 
    50                  55                  60                  


Trp Asp Pro Asn Asp Glu Glu Ser Met Asn Ser Pro Cys Trp Gln Val 
65                  70                  75                  80  


Lys Trp Gln Leu Arg Gln Leu Val Arg Lys Met Ile Leu Arg Thr Ser 
                85                  90                  95      


Glu Glu Thr Ile Ser Thr Val Gln Glu Lys Gln Gln Asn Ile Ser Pro 
            100                 105                 110         


Leu Val Arg Glu Arg Gly Pro Gln Arg Val Ala Ala His Ile Thr Gly 
        115                 120                 125             


Thr Arg Gly Arg Ser Asn Thr Leu Ser Ser Pro Asn Ser Lys Asn Glu 
    130                 135                 140                 


Lys Ala Leu Gly Arg Lys Ile Asn Ser Trp Glu Ser Ser Arg Ser Gly 
145                 150                 155                 160 


His Ser Phe Leu Ser Asn Leu His Leu Arg Asn Gly Glu Leu Val Ile 
                165                 170                 175     


His Glu Lys Gly Phe Tyr Tyr Ile Tyr Ser Gln Thr Tyr Phe Arg Phe 
            180                 185                 190         


Gln Glu Glu Ile Lys Glu Asn Thr Lys Asn Asp Lys Gln Met Val Gln 
        195                 200                 205             


Tyr Ile Tyr Lys Tyr Thr Ser Tyr Pro Asp Pro Ile Leu Leu Met Lys 
    210                 215                 220                 


Ser Ala Arg Asn Ser Cys Trp Ser Lys Asp Ala Glu Tyr Gly Leu Tyr 
225                 230                 235                 240 


Ser Ile Tyr Gln Gly Gly Ile Phe Glu Leu Lys Glu Asn Asp Arg Ile 
                245                 250                 255     


Phe Val Ser Val Thr Asn Glu His Leu Ile Asp Met Asp His Glu Ala 
            260                 265                 270         


Ser Phe Phe Gly Ala Phe Leu Val Gly 
        275                 280     


<210>  213
<211>  317
<212>  PRT
<213>  Homo sapiens

<400>  213

Met Arg Arg Ala Ser Arg Asp Tyr Thr Lys Tyr Leu Arg Gly Ser Glu 
1               5                   10                  15      


Glu Met Gly Gly Gly Pro Gly Ala Pro His Glu Gly Pro Leu His Ala 
            20                  25                  30          


Pro Pro Pro Pro Ala Pro His Gln Pro Pro Ala Ala Ser Arg Ser Met 
        35                  40                  45              


Phe Val Ala Leu Leu Gly Leu Gly Leu Gly Gln Val Val Cys Ser Val 
    50                  55                  60                  


Ala Leu Phe Phe Tyr Phe Arg Ala Gln Met Asp Pro Asn Arg Ile Ser 
65                  70                  75                  80  


Glu Asp Gly Thr His Cys Ile Tyr Arg Ile Leu Arg Leu His Glu Asn 
                85                  90                  95      


Ala Asp Phe Gln Asp Thr Thr Leu Glu Ser Gln Asp Thr Lys Leu Ile 
            100                 105                 110         


Pro Asp Ser Cys Arg Arg Ile Lys Gln Ala Phe Gln Gly Ala Val Gln 
        115                 120                 125             


Lys Glu Leu Gln His Ile Val Gly Ser Gln His Ile Arg Ala Glu Lys 
    130                 135                 140                 


Ala Met Val Asp Gly Ser Trp Leu Asp Leu Ala Lys Arg Ser Lys Leu 
145                 150                 155                 160 


Glu Ala Gln Pro Phe Ala His Leu Thr Ile Asn Ala Thr Asp Ile Pro 
                165                 170                 175     


Ser Gly Ser His Lys Val Ser Leu Ser Ser Trp Tyr His Asp Arg Gly 
            180                 185                 190         


Trp Ala Lys Ile Ser Asn Met Thr Phe Ser Asn Gly Lys Leu Ile Val 
        195                 200                 205             


Asn Gln Asp Gly Phe Tyr Tyr Leu Tyr Ala Asn Ile Cys Phe Arg His 
    210                 215                 220                 


His Glu Thr Ser Gly Asp Leu Ala Thr Glu Tyr Leu Gln Leu Met Val 
225                 230                 235                 240 


Tyr Val Thr Lys Thr Ser Ile Lys Ile Pro Ser Ser His Thr Leu Met 
                245                 250                 255     


Lys Gly Gly Ser Thr Lys Tyr Trp Ser Gly Asn Ser Glu Phe His Phe 
            260                 265                 270         


Tyr Ser Ile Asn Val Gly Gly Phe Phe Lys Leu Arg Ser Gly Glu Glu 
        275                 280                 285             


Ile Ser Ile Glu Val Ser Asn Pro Ser Leu Leu Asp Pro Asp Gln Asp 
    290                 295                 300                 


Ala Thr Tyr Phe Gly Ala Phe Lys Val Arg Asp Ile Asp 
305                 310                 315         


<210>  214
<211>  249
<212>  PRT
<213>  Homo sapiens

<400>  214

Met Ala Ala Arg Arg Ser Gln Arg Arg Arg Gly Arg Arg Gly Glu Pro 
1               5                   10                  15      


Gly Thr Ala Leu Leu Val Pro Leu Ala Leu Gly Leu Gly Leu Ala Leu 
            20                  25                  30          


Ala Cys Leu Gly Leu Leu Leu Ala Val Val Ser Leu Gly Ser Arg Ala 
        35                  40                  45              


Ser Leu Ser Ala Gln Glu Pro Ala Gln Glu Glu Leu Val Ala Glu Glu 
    50                  55                  60                  


Asp Gln Asp Pro Ser Glu Leu Asn Pro Gln Thr Glu Glu Ser Gln Asp 
65                  70                  75                  80  


Pro Ala Pro Phe Leu Asn Arg Leu Val Arg Pro Arg Arg Ser Ala Pro 
                85                  90                  95      


Lys Gly Arg Lys Thr Arg Ala Arg Arg Ala Ile Ala Ala His Tyr Glu 
            100                 105                 110         


Val His Pro Arg Pro Gly Gln Asp Gly Ala Gln Ala Gly Val Asp Gly 
        115                 120                 125             


Thr Val Ser Gly Trp Glu Glu Ala Arg Ile Asn Ser Ser Ser Pro Leu 
    130                 135                 140                 


Arg Tyr Asn Arg Gln Ile Gly Glu Phe Ile Val Thr Arg Ala Gly Leu 
145                 150                 155                 160 


Tyr Tyr Leu Tyr Cys Gln Val His Phe Asp Glu Gly Lys Ala Val Tyr 
                165                 170                 175     


Leu Lys Leu Asp Leu Leu Val Asp Gly Val Leu Ala Leu Arg Cys Leu 
            180                 185                 190         


Glu Glu Phe Ser Ala Thr Ala Ala Ser Ser Leu Gly Pro Gln Leu Arg 
        195                 200                 205             


Leu Cys Gln Val Ser Gly Leu Leu Ala Leu Arg Pro Gly Ser Ser Leu 
    210                 215                 220                 


Arg Ile Arg Thr Leu Pro Trp Ala His Leu Lys Ala Ala Pro Phe Leu 
225                 230                 235                 240 


Thr Tyr Phe Gly Leu Phe Gln Val His 
                245                 


<210>  215
<211>  250
<212>  PRT
<213>  Homo sapiens

<400>  215

Met Pro Ala Ser Ser Pro Phe Leu Leu Ala Pro Lys Gly Pro Pro Gly 
1               5                   10                  15      


Asn Met Gly Gly Pro Val Arg Glu Pro Ala Leu Ser Val Ala Leu Trp 
            20                  25                  30          


Leu Ser Trp Gly Ala Ala Leu Gly Ala Val Ala Cys Ala Met Ala Leu 
        35                  40                  45              


Leu Thr Gln Gln Thr Glu Leu Gln Ser Leu Arg Arg Glu Val Ser Arg 
    50                  55                  60                  


Leu Gln Gly Thr Gly Gly Pro Ser Gln Asn Gly Glu Gly Tyr Pro Trp 
65                  70                  75                  80  


Gln Ser Leu Pro Glu Gln Ser Ser Asp Ala Leu Glu Ala Trp Glu Asn 
                85                  90                  95      


Gly Glu Arg Ser Arg Lys Arg Arg Ala Val Leu Thr Gln Lys Gln Lys 
            100                 105                 110         


Lys Gln His Ser Val Leu His Leu Val Pro Ile Asn Ala Thr Ser Lys 
        115                 120                 125             


Asp Asp Ser Asp Val Thr Glu Val Met Trp Gln Pro Ala Leu Arg Arg 
    130                 135                 140                 


Gly Arg Gly Leu Gln Ala Gln Gly Tyr Gly Val Arg Ile Gln Asp Ala 
145                 150                 155                 160 


Gly Val Tyr Leu Leu Tyr Ser Gln Val Leu Phe Gln Asp Val Thr Phe 
                165                 170                 175     


Thr Met Gly Gln Val Val Ser Arg Glu Gly Gln Gly Arg Gln Glu Thr 
            180                 185                 190         


Leu Phe Arg Cys Ile Arg Ser Met Pro Ser His Pro Asp Arg Ala Tyr 
        195                 200                 205             


Asn Ser Cys Tyr Ser Ala Gly Val Phe His Leu His Gln Gly Asp Ile 
    210                 215                 220                 


Leu Ser Val Ile Ile Pro Arg Ala Arg Ala Lys Leu Asn Leu Ser Pro 
225                 230                 235                 240 


His Gly Thr Phe Leu Gly Phe Val Lys Leu 
                245                 250 


<210>  216
<211>  285
<212>  PRT
<213>  Homo sapiens

<400>  216

Met Asp Asp Ser Thr Glu Arg Glu Gln Ser Arg Leu Thr Ser Cys Leu 
1               5                   10                  15      


Lys Lys Arg Glu Glu Met Lys Leu Lys Glu Cys Val Ser Ile Leu Pro 
            20                  25                  30          


Arg Lys Glu Ser Pro Ser Val Arg Ser Ser Lys Asp Gly Lys Leu Leu 
        35                  40                  45              


Ala Ala Thr Leu Leu Leu Ala Leu Leu Ser Cys Cys Leu Thr Val Val 
    50                  55                  60                  


Ser Phe Tyr Gln Val Ala Ala Leu Gln Gly Asp Leu Ala Ser Leu Arg 
65                  70                  75                  80  


Ala Glu Leu Gln Gly His His Ala Glu Lys Leu Pro Ala Gly Ala Gly 
                85                  90                  95      


Ala Pro Lys Ala Gly Leu Glu Glu Ala Pro Ala Val Thr Ala Gly Leu 
            100                 105                 110         


Lys Ile Phe Glu Pro Pro Ala Pro Gly Glu Gly Asn Ser Ser Gln Asn 
        115                 120                 125             


Ser Arg Asn Lys Arg Ala Val Gln Gly Pro Glu Glu Thr Val Thr Gln 
    130                 135                 140                 


Asp Cys Leu Gln Leu Ile Ala Asp Ser Glu Thr Pro Thr Ile Gln Lys 
145                 150                 155                 160 


Gly Ser Tyr Thr Phe Val Pro Trp Leu Leu Ser Phe Lys Arg Gly Ser 
                165                 170                 175     


Ala Leu Glu Glu Lys Glu Asn Lys Ile Leu Val Lys Glu Thr Gly Tyr 
            180                 185                 190         


Phe Phe Ile Tyr Gly Gln Val Leu Tyr Thr Asp Lys Thr Tyr Ala Met 
        195                 200                 205             


Gly His Leu Ile Gln Arg Lys Lys Val His Val Phe Gly Asp Glu Leu 
    210                 215                 220                 


Ser Leu Val Thr Leu Phe Arg Cys Ile Gln Asn Met Pro Glu Thr Leu 
225                 230                 235                 240 


Pro Asn Asn Ser Cys Tyr Ser Ala Gly Ile Ala Lys Leu Glu Glu Gly 
                245                 250                 255     


Asp Glu Leu Gln Leu Ala Ile Pro Arg Glu Asn Ala Gln Ile Ser Leu 
            260                 265                 270         


Asp Gly Asp Val Thr Phe Phe Gly Ala Leu Lys Leu Leu 
        275                 280                 285 


<210>  217
<211>  240
<212>  PRT
<213>  Homo sapiens

<400>  217

Met Glu Glu Ser Val Val Arg Pro Ser Val Phe Val Val Asp Gly Gln 
1               5                   10                  15      


Thr Asp Ile Pro Phe Thr Arg Leu Gly Arg Ser His Arg Arg Gln Ser 
            20                  25                  30          


Cys Ser Val Ala Arg Val Gly Leu Gly Leu Leu Leu Leu Leu Met Gly 
        35                  40                  45              


Ala Gly Leu Ala Val Gln Gly Trp Phe Leu Leu Gln Leu His Trp Arg 
    50                  55                  60                  


Leu Gly Glu Met Val Thr Arg Leu Pro Asp Gly Pro Ala Gly Ser Trp 
65                  70                  75                  80  


Glu Gln Leu Ile Gln Glu Arg Arg Ser His Glu Val Asn Pro Ala Ala 
                85                  90                  95      


His Leu Thr Gly Ala Asn Ser Ser Leu Thr Gly Ser Gly Gly Pro Leu 
            100                 105                 110         


Leu Trp Glu Thr Gln Leu Gly Leu Ala Phe Leu Arg Gly Leu Ser Tyr 
        115                 120                 125             


His Asp Gly Ala Leu Val Val Thr Lys Ala Gly Tyr Tyr Tyr Ile Tyr 
    130                 135                 140                 


Ser Lys Val Gln Leu Gly Gly Val Gly Cys Pro Leu Gly Leu Ala Ser 
145                 150                 155                 160 


Thr Ile Thr His Gly Leu Tyr Lys Arg Thr Pro Arg Tyr Pro Glu Glu 
                165                 170                 175     


Leu Glu Leu Leu Val Ser Gln Gln Ser Pro Cys Gly Arg Ala Thr Ser 
            180                 185                 190         


Ser Ser Arg Val Trp Trp Asp Ser Ser Phe Leu Gly Gly Val Val His 
        195                 200                 205             


Leu Glu Ala Gly Glu Lys Val Val Val Arg Val Leu Asp Glu Arg Leu 
    210                 215                 220                 


Val Arg Leu Arg Asp Gly Thr Arg Ser Tyr Phe Gly Ala Phe Met Val 
225                 230                 235                 240 


<210>  218
<211>  251
<212>  PRT
<213>  Homo sapiens

<400>  218

Met Ala Glu Asp Leu Gly Leu Ser Phe Gly Glu Thr Ala Ser Val Glu 
1               5                   10                  15      


Met Leu Pro Glu His Gly Ser Cys Arg Pro Lys Ala Arg Ser Ser Ser 
            20                  25                  30          


Ala Arg Trp Ala Leu Thr Cys Cys Leu Val Leu Leu Pro Phe Leu Ala 
        35                  40                  45              


Gly Leu Thr Thr Tyr Leu Leu Val Ser Gln Leu Arg Ala Gln Gly Glu 
    50                  55                  60                  


Ala Cys Val Gln Phe Gln Ala Leu Lys Gly Gln Glu Phe Ala Pro Ser 
65                  70                  75                  80  


His Gln Gln Val Tyr Ala Pro Leu Arg Ala Asp Gly Asp Lys Pro Arg 
                85                  90                  95      


Ala His Leu Thr Val Val Arg Gln Thr Pro Thr Gln His Phe Lys Asn 
            100                 105                 110         


Gln Phe Pro Ala Leu His Trp Glu His Glu Leu Gly Leu Ala Phe Thr 
        115                 120                 125             


Lys Asn Arg Met Asn Tyr Thr Asn Lys Phe Leu Leu Ile Pro Glu Ser 
    130                 135                 140                 


Gly Asp Tyr Phe Ile Tyr Ser Gln Val Thr Phe Arg Gly Met Thr Ser 
145                 150                 155                 160 


Glu Cys Ser Glu Ile Arg Gln Ala Gly Arg Pro Asn Lys Pro Asp Ser 
                165                 170                 175     


Ile Thr Val Val Ile Thr Lys Val Thr Asp Ser Tyr Pro Glu Pro Thr 
            180                 185                 190         


Gln Leu Leu Met Gly Thr Lys Ser Val Cys Glu Val Gly Ser Asn Trp 
        195                 200                 205             


Phe Gln Pro Ile Tyr Leu Gly Ala Met Phe Ser Leu Gln Glu Gly Asp 
    210                 215                 220                 


Lys Leu Met Val Asn Val Ser Asp Ile Ser Leu Val Asp Tyr Thr Lys 
225                 230                 235                 240 


Glu Asp Lys Thr Phe Phe Gly Ala Phe Leu Leu 
                245                 250     


<210>  219
<211>  199
<212>  PRT
<213>  Homo sapiens

<400>  219

Met Thr Leu His Pro Ser Pro Ile Thr Cys Glu Phe Leu Phe Ser Thr 
1               5                   10                  15      


Ala Leu Ile Ser Pro Lys Met Cys Leu Ser His Leu Glu Asn Met Pro 
            20                  25                  30          


Leu Ser His Ser Arg Thr Gln Gly Ala Gln Arg Ser Ser Trp Lys Leu 
        35                  40                  45              


Trp Leu Phe Cys Ser Ile Val Met Leu Leu Phe Leu Cys Ser Phe Ser 
    50                  55                  60                  


Trp Leu Ile Phe Ile Phe Leu Gln Leu Glu Thr Ala Lys Glu Pro Cys 
65                  70                  75                  80  


Met Ala Lys Phe Gly Pro Leu Pro Ser Lys Trp Gln Met Ala Ser Ser 
                85                  90                  95      


Glu Pro Pro Cys Val Asn Lys Val Ser Asp Trp Lys Leu Glu Ile Leu 
            100                 105                 110         


Gln Asn Gly Leu Tyr Leu Ile Tyr Gly Gln Val Ala Pro Asn Ala Asn 
        115                 120                 125             


Tyr Asn Asp Val Ala Pro Phe Glu Val Arg Leu Tyr Lys Asn Lys Asp 
    130                 135                 140                 


Met Ile Gln Thr Leu Thr Asn Lys Ser Lys Ile Gln Asn Val Gly Gly 
145                 150                 155                 160 


Thr Tyr Glu Leu His Val Gly Asp Thr Ile Asp Leu Ile Phe Asn Ser 
                165                 170                 175     


Glu His Gln Val Leu Lys Asn Asn Thr Tyr Trp Gly Ile Ile Leu Leu 
            180                 185                 190         


Ala Asn Pro Gln Phe Ile Ser 
        195                 


<210>  220
<211>  391
<212>  PRT
<213>  Homo sapiens

<400>  220

Met Gly Tyr Pro Glu Val Glu Arg Arg Glu Leu Leu Pro Ala Ala Ala 
1               5                   10                  15      


Pro Arg Glu Arg Gly Ser Gln Gly Cys Gly Cys Gly Gly Ala Pro Ala 
            20                  25                  30          


Arg Ala Gly Glu Gly Asn Ser Cys Leu Leu Phe Leu Gly Phe Phe Gly 
        35                  40                  45              


Leu Ser Leu Ala Leu His Leu Leu Thr Leu Cys Cys Tyr Leu Glu Leu 
    50                  55                  60                  


Arg Ser Glu Leu Arg Arg Glu Arg Gly Ala Glu Ser Arg Leu Gly Gly 
65                  70                  75                  80  


Ser Gly Thr Pro Gly Thr Ser Gly Thr Leu Ser Ser Leu Gly Gly Leu 
                85                  90                  95      


Asp Pro Asp Ser Pro Ile Thr Ser His Leu Gly Gln Pro Ser Pro Lys 
            100                 105                 110         


Gln Gln Pro Leu Glu Pro Gly Glu Ala Ala Leu His Ser Asp Ser Gln 
        115                 120                 125             


Asp Gly His Gln Met Ala Leu Leu Asn Phe Phe Phe Pro Asp Glu Lys 
    130                 135                 140                 


Pro Tyr Ser Glu Glu Glu Ser Arg Arg Val Arg Arg Asn Lys Arg Ser 
145                 150                 155                 160 


Lys Ser Asn Glu Gly Ala Asp Gly Pro Val Lys Asn Lys Lys Lys Gly 
                165                 170                 175     


Lys Lys Ala Gly Pro Pro Gly Pro Asn Gly Pro Pro Gly Pro Pro Gly 
            180                 185                 190         


Pro Pro Gly Pro Gln Gly Pro Pro Gly Ile Pro Gly Ile Pro Gly Ile 
        195                 200                 205             


Pro Gly Thr Thr Val Met Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly 
    210                 215                 220                 


Pro Gln Gly Pro Pro Gly Leu Gln Gly Pro Ser Gly Ala Ala Asp Lys 
225                 230                 235                 240 


Ala Gly Thr Arg Glu Asn Gln Pro Ala Val Val His Leu Gln Gly Gln 
                245                 250                 255     


Gly Ser Ala Ile Gln Val Lys Asn Asp Leu Ser Gly Gly Val Leu Asn 
            260                 265                 270         


Asp Trp Ser Arg Ile Thr Met Asn Pro Lys Val Phe Lys Leu His Pro 
        275                 280                 285             


Arg Ser Gly Glu Leu Glu Val Leu Val Asp Gly Thr Tyr Phe Ile Tyr 
    290                 295                 300                 


Ser Gln Val Glu Val Tyr Tyr Ile Asn Phe Thr Asp Phe Ala Ser Tyr 
305                 310                 315                 320 


Glu Val Val Val Asp Glu Lys Pro Phe Leu Gln Cys Thr Arg Ser Ile 
                325                 330                 335     


Glu Thr Gly Lys Thr Asn Tyr Asn Thr Cys Tyr Thr Ala Gly Val Cys 
            340                 345                 350         


Leu Leu Lys Ala Arg Gln Lys Ile Ala Val Lys Met Val His Ala Asp 
        355                 360                 365             


Ile Ser Ile Asn Met Ser Lys His Thr Thr Phe Phe Gly Ala Ile Arg 
    370                 375                 380                 


Leu Gly Glu Ala Pro Ala Ser 
385                 390     


