                               SEQUENCE LISTING

<110> UNIVERSITY OF AUCKLAND
      OCUNEXUS THERAPEUTICS, INC.
 
<120> NOVEL PEPTIDES AND PEPTIDOMIMETICS

<130> E3697-00488

<140> PCT/US2017/030688
<141> 2017-05-02

<150> 62/331,416
<151> 2016-05-03

<160> 98    

<170> PatentIn version 3.5

<210> 1
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 1
Ala Asp Cys Phe Leu Ser Arg Pro Thr Glu Lys Thr 
1               5                   10          


<210> 2
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 2
Val Asp Cys Ala Leu Ser Arg Pro Thr Glu Lys Thr 
1               5                   10          


<210> 3
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 3
Val Asp Cys Phe Leu Ala Arg Pro Thr Glu Lys Thr 
1               5                   10          


<210> 4
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 4
Val Asp Cys Phe Leu Ser Arg Pro Ala Glu Lys Thr 
1               5                   10          


<210> 5
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 5
Val Asp Cys Phe Leu Ser Arg Pro Thr Glu Lys Ala 
1               5                   10          


<210> 6
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 6
Cys Phe Leu Ser Arg Pro Thr Ala Lys Thr 
1               5                   10  


<210> 7
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 7
Cys Ala Leu Ser Arg Pro Thr Glu Lys Thr 
1               5                   10  


<210> 8
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 8
Cys Phe Leu Ala Arg Pro Thr Glu Lys Thr 
1               5                   10  


<210> 9
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 9
Cys Phe Leu Ser Arg Pro Ala Glu Lys Thr 
1               5                   10  


<210> 10
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 10
Cys Phe Leu Ser Arg Pro Thr Glu Lys Ala 
1               5                   10  


<210> 11
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 11
Val Asp Cys Phe Ile Ser Arg Pro Thr Glu Lys Thr 
1               5                   10          


<210> 12
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 12
Val Asp Cys Phe Val Ser Arg Pro Thr Glu Lys Thr 
1               5                   10          


<210> 13
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 13
Val Asn Cys Tyr Val Ser Arg Pro Thr Glu Lys Asn 
1               5                   10          


<210> 14
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 14
Ile Asp Cys Phe Val Ser Arg Pro Thr Glu Lys Thr 
1               5                   10          


<210> 15
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 15
Val Asp Cys Phe Val Ser Arg Pro Thr Glu Lys Thr 
1               5                   10          


<210> 16
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 16
Val Asp Cys Phe Val Ser Arg Pro Thr Glu Lys Thr 
1               5                   10          


<210> 17
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 17
Val Asp Cys Phe Val Ser Arg Pro Thr Glu Lys Thr 
1               5                   10          


<210> 18
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 18
Val Asp Cys Tyr Ile Ser Arg Pro Thr Glu Lys Lys 
1               5                   10          


<210> 19
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 19
Val Asp Cys Phe Ile Ser Lys Pro Ser Glu Lys Asn 
1               5                   10          


<210> 20
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 20
Val Asp Cys Tyr Ile Ala Arg Pro Thr Glu Lys Lys 
1               5                   10          


<210> 21
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 21
Val Asp Cys Phe Ile Ser Lys Pro Thr Glu Lys Thr 
1               5                   10          


<210> 22
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 22
Val Asp Cys Phe Val Ser Arg Pro Thr Glu Lys Thr 
1               5                   10          


<210> 23
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 23
Val Asp Cys Phe Ile Ser Arg Pro Thr Glu Lys Thr 
1               5                   10          


<210> 24
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 24
Val Asp Cys Phe Val Ser Arg Pro Thr Glu Lys Thr 
1               5                   10          


<210> 25
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 25
Val Glu Cys Tyr Val Ser Arg Pro Thr Glu Lys Thr 
1               5                   10          


<210> 26
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 26
Val Asp Cys Phe Val Ser Arg Pro Thr Glu Lys Thr 
1               5                   10          


<210> 27
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 27
Val Asp Cys Tyr Val Ser Arg Pro Thr Glu Lys Ser 
1               5                   10          


<210> 28
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 28
Ile Thr Cys Asn Leu Ser Arg Pro Ser Glu Lys Thr 
1               5                   10          


<210> 29
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 29
Ile Thr Cys Asn Leu Ser Arg Pro Ser Glu Lys Thr 
1               5                   10          


<210> 30
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 30
Ile Asp Cys Phe Val Ser Arg Pro Thr Glu Lys Thr 
1               5                   10          


<210> 31
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 31
Val Asp Cys Phe Val Ser Arg Pro Thr Glu Lys Thr 
1               5                   10          


<210> 32
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 32
Val Asp Cys Phe Ile Ser Arg Pro Thr Glu Lys Thr 
1               5                   10          


<210> 33
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 33
Ile Thr Cys Asn Leu Ser Arg Pro Ser Glu Lys Thr 
1               5                   10          


<210> 34
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 34
Val Asp Cys Tyr Val Ser Arg Pro Thr Glu Lys Ser 
1               5                   10          


<210> 35
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 35
Val Glu Cys Tyr Val Ser Arg Pro Thr Glu Lys Thr 
1               5                   10          


<210> 36
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 36
Ile Asp Cys Phe Val Ser Arg Pro Thr Glu Lys Thr 
1               5                   10          


<210> 37
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 37
Val Asp Cys Tyr Ile Ser Arg Pro Thr Glu Lys Lys 
1               5                   10          


<210> 38
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 38
Val Asp Cys Phe Ile Ser Lys Pro Ser Glu Lys Asn 
1               5                   10          


<210> 39
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 39
Val Asp Cys Tyr Ile Ala Arg Pro Thr Glu Lys Lys 
1               5                   10          


<210> 40
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 40
Val Asp Cys Phe Ile Ser Lys Pro Thr Glu Lys Thr 
1               5                   10          


<210> 41
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 41
Ile Asp Cys Phe Val Ser Arg Pro Thr Glu Lys Thr 
1               5                   10          


<210> 42
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 42
Val Asn Cys Tyr Val Ser Arg Pro Thr Glu Lys Asn 
1               5                   10          


<210> 43
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 43
Ile Asp Cys Phe Ile Ser Arg Pro Thr Glu Lys Thr 
1               5                   10          


<210> 44
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 44
Val Cys Tyr Asp Lys Ser Phe Pro Ile Ser His Val Arg 
1               5                   10              


<210> 45
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 45
Val Asp Cys Phe Leu Ser Arg Pro Thr Glu Lys Thr 
1               5                   10          


<210> 46
<211> 26
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 46
Val Asp Cys Phe Leu Ser Arg Pro Thr Glu Lys Thr Gly Val Cys Tyr 
1               5                   10                  15      


Asp Lys Ser Phe Pro Ile Ser His Val Arg 
            20                  25      


<210> 47
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 47
Val Asp Cys Phe Leu Ser Arg Pro Thr Glu Lys Thr 
1               5                   10          


<210> 48
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 48
Val Asn Cys Tyr Val Ser Arg Pro Thr Glu Lys Asn 
1               5                   10          


<210> 49
<211> 25
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 49
Val Asp Cys Phe Leu Ser Arg Pro Thr Glu Lys Thr Gly Val Asn Cys 
1               5                   10                  15      


Tyr Val Ser Arg Pro Thr Glu Lys Asn 
            20                  25  


<210> 50
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 50
Val Asp Cys Phe Val Ser Arg Pro Thr Glu Lys Asn 
1               5                   10          


<210> 51
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 51
Val Asp Cys Phe Leu Ser Arg Pro Thr Glu Lys Asn 
1               5                   10          


<210> 52
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 52
Val Asp Cys Phe Val Ser Arg Pro Thr Glu Lys Thr 
1               5                   10          


<210> 53

<400> 53
000


<210> 54
<211> 16
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: ANTP
      peptide

<400> 54
Arg Gln Pro Lys Ile Trp Phe Pro Asn Arg Arg Lys Pro Trp Lys Lys 
1               5                   10                  15      


<210> 55
<211> 11
<212> PRT
<213> Human immunodeficiency virus

<400> 55
Gly Arg Lys Lys Arg Arg Gln Arg Pro Pro Gln 
1               5                   10      


<210> 56
<211> 26
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: Transportan 
      peptide

<400> 56
Gly Trp Thr Leu Asn Ser Ala Gly Tyr Leu Leu Gly Lys Ile Asn Lys 
1               5                   10                  15      


Ala Leu Ala Ala Leu Ala Lys Lys Ile Leu 
            20                  25      


<210> 57
<211> 21
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: Buforin II 
      peptide

<400> 57
Thr Arg Ser Ser Arg Ala Gly Leu Gln Phe Pro Val Gly Arg Val His 
1               5                   10                  15      


Arg Leu Leu Arg Lys 
            20      


<210> 58
<211> 9
<212> PRT
<213> Human immunodeficiency virus

<400> 58
Arg Lys Lys Arg Arg Gln Arg Arg Arg 
1               5                   


<210> 59
<211> 16
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: Penetratin 
      peptide

<400> 59
Arg Gln Ile Lys Ile Trp Phe Gln Asn Arg Arg Met Lys Trp Lys Lys 
1               5                   10                  15      


<210> 60
<211> 18
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: MAP 
      peptide

<400> 60
Lys Leu Ala Leu Lys Leu Ala Leu Lys Ala Leu Lys Ala Ala Leu Lys 
1               5                   10                  15      


Leu Ala 
        


<210> 61
<211> 16
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: K-FGF 
      peptide

<400> 61
Ala Ala Val Ala Leu Leu Pro Ala Val Leu Leu Ala Leu Leu Ala Pro 
1               5                   10                  15      


<210> 62
<211> 10
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: Ku70 
      peptide

<400> 62
Val Pro Met Leu Lys Pro Met Leu Lys Glu 
1               5                   10  


<210> 63
<211> 28
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: Prion 
      peptide

<400> 63
Met Ala Asn Leu Gly Tyr Trp Leu Leu Ala Leu Phe Val Thr Met Trp 
1               5                   10                  15      


Thr Asp Val Gly Leu Cys Lys Lys Arg Pro Lys Pro 
            20                  25              


<210> 64
<211> 18
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: pVEC 
      peptide

<400> 64
Leu Leu Ile Ile Leu Arg Arg Arg Ile Arg Lys Gln Ala His Ala His 
1               5                   10                  15      


Ser Lys 
        


<210> 65
<211> 21
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: Pep-1 
      peptide

<400> 65
Lys Glu Thr Trp Trp Glu Thr Trp Trp Thr Glu Trp Ser Gln Pro Lys 
1               5                   10                  15      


Lys Lys Arg Arg Val 
            20      


<210> 66
<211> 18
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: SynB1 
      peptide

<400> 66
Arg Gly Gly Arg Leu Ser Tyr Ser Arg Arg Arg Phe Ser Thr Ser Thr 
1               5                   10                  15      


Gly Arg 
        


<210> 67
<211> 15
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: Pep-7 
      peptide

<400> 67
Ser Asp Leu Trp Glu Met Met Met Val Ser Leu Ala Cys Gln Tyr 
1               5                   10                  15  


<210> 68
<211> 12
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: HN-1 
      peptide

<400> 68
Thr Ser Pro Leu Asn Ile His Asn Gly Gln Lys Leu 
1               5                   10          


<210> 69
<211> 16
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: plsl 
      peptide

<400> 69
Arg Val Ile Arg Val Trp Phe Gln Asn Lys Arg Cys Lys Asp Lys Lys 
1               5                   10                  15      


<210> 70
<211> 27
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: MGB Peptide P-beta 
      peptide

<400> 70
Gly Ala Leu Phe Leu Gly Phe Leu Gly Ala Ala Gly Ser Thr Met Gly 
1               5                   10                  15      


Ala Trp Ser Gln Pro Lys Lys Lys Arg Lys Val 
            20                  25          


<210> 71
<211> 27
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: MGB Peptide P-alpha 
      peptide

<400> 71
Gly Ala Leu Phe Leu Ala Phe Leu Ala Ala Ala Leu Ser Leu Met Gly 
1               5                   10                  15      


Leu Trp Ser Gln Pro Lys Lys Lys Arg Arg Val 
            20                  25          


<210> 72
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 72
Val Asp Cys Leu Ser Arg Pro Thr Glu Lys Thr 
1               5                   10      


<210> 73
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Phe, or an amino acid selected from the group consisting of Ala,
      Ile, Leu, Val, dehydroalanine, aminoisobutyric acid, and/or Trp,
      Tyr, Met, Ile, Leu, and/or Ser, Asn, Cys, Gln, Thr, Asp, Glu, 
      Arg, His, Lys, Pro, and/or Nva or Nle, and/or tert-butylglycine,

<220>
<221> MOD_RES
<222> (4)..(4)
<223> continued from above; phenylglycine, 7-azatryptophan, 
      4-fluorophenylalanine, N-methyl-methionine, N-methyl-valine, 
      N-methyl-alanine, sarcosine, N-methyl-tert-butylglycine, 
      N-methyl-leucine, N-methyl-phenylglycine, N-methyl-isoleucine,

<220>
<221> MOD_RES
<222> (4)..(4)
<223> continued from above; N-methyl-tryptophan, N-methyl-7-
      azatryptophan, N-methyl-phenylalanine, N-methyl-4-
      fluorophenylalanine, N-methyl-threonine, N-methyl-tyrosine, 
      N-methyl-valine, and N-methyl-lysine, 

<220>
<221> MOD_RES
<222> (4)..(4)
<223> continued from above; and/or a D-enantiomer of any of the 
      foregoing

<220>
<221> MOD_RES
<222> (9)..(9)
<223> Thr, or an amino acid selected from the group consisting of 
      Ser, Asn, Ala, Ile, Leu, Val, dehydroalanine, aminoisobutyric 
      acid, Asp, Glu, Lys, Met, His, Pro, Gln, Arg, Ser, Nva or Nle 

<220>
<221> MOD_RES
<222> (10)..(10)
<223> Glu, Ala, dehydroalanine, aminoisobutyric acid, Asp, Lys, Gln,
      Gly, His, Arg, Asn, Met, Pro, Ser, Thr, Nva or Nle 

<220>
<221> MOD_RES
<222> (12)..(12)
<223> Thr, or an amino acid selected from the group consisting of Ser,
      Asn, Ala, Ile, Leu, Val, dehydroalanine, aminoisobutyric acid,
      Asp, Glu, Lys, Met, His, Pro, Gln, Arg, Ser, Nva or Nle 

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 73
Val Asp Cys Xaa Leu Ser Arg Pro Xaa Xaa Lys Xaa 
1               5                   10              


<210> 74
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Val, Ala or an amino acid selected from the group consisting of 
      Ile, Leu, Met, Phe, Thr, Cys, Tyr, dehydroalanine, 
      aminoisobutyric acid, Nva, Nle, tert-butylglycine, phenylglycine,
      7-azatryptophan, 4-fluorophenylalanine, N-methyl-methionine, 

<220>
<221> MOD_RES
<222> (1)..(1)
<223> continued from above; N-methyl-valine, N-methyl-alanine, sarcosine,
      N-methyl-tert-butylglycine, N-methyl-leucine, N-methyl-
      phenylglycine, N-methyl-isoleucine, N-methyl-tryptophan, N-methyl-
      7-azatryptophan, N-methyl-phenylalanine, 

<220>
<221> MOD_RES
<222> (1)..(1)
<223> continued from above; N-methyl-4-fluorophenylalanine, N-methyl-
      threonine, N-methyl-tyrosine, N-methyl-valine, and N-methyl-lysine,
      and/or a D-enantiomer of any of the foregoing

<220>
<221> MOD_RES
<222> (4)..(4)
<223> Phe, or an amino acid selected from the group consisting of Ala,
      Ile, Leu, Val, dehydroalanine, aminoisobutyric acid, and/or Trp,
      Tyr, Met, Ile, Leu, and/or Ser, Asn, Cys, Gln, Thr, Asp, Glu, 
      Arg, His, Lys, Pro, and/or Nva or Nle, and/or tert-butylglycine,

<220>
<221> MOD_RES
<222> (4)..(4)
<223> continued from above; phenylglycine, 7-azatryptophan, 
      4-fluorophenylalanine, N-methyl-methionine, N-methyl-valine, 
      N-methyl-alanine, sarcosine, N-methyl-tert-butylglycine, 
      N-methyl-leucine, N-methyl-phenylglycine, N-methyl-isoleucine,

<220>
<221> MOD_RES
<222> (4)..(4)
<223> continued from above; N-methyl-tryptophan, N-methyl-7-
      azatryptophan, N-methyl-phenylalanine, N-methyl-4-
      fluorophenylalanine, N-methyl-threonine, N-methyl-tyrosine, 
      N-methyl-valine, and N-methyl-lysine, 

<220>
<221> MOD_RES
<222> (4)..(4)
<223> continued from above; and/or a D-enantiomer of any of the 
      foregoing

<220>
<221> MOD_RES
<222> (6)..(6)
<223> Ser, Ala or an amino acid selected from the group consisting 
      of Asn, Thr, Cys, Gly, Asp, Glu, Lys, Gln, Gly, Pro, His
      or Arg 

<220>
<221> MOD_RES
<222> (9)..(9)
<223> Thr, or an amino acid selected from the group consisting of Ser,
      Asn, Ala, Ile, Leu, Val, dehydroalanine, aminoisobutyric acid, 
      Asp, Glu, Lys, Met, His, Pro, Gln, Arg, Ser, Nva or Nle 

<220>
<221> MOD_RES
<222> (10)..(10)
<223> Glu, Ala, dehydroalanine, aminoisobutyric acid, Asp, Lys, Gln,
      Gly, His, Arg, Asn, Met, Pro, Ser, Thr, Nva or Nle 

<220>
<221> MOD_RES
<222> (12)..(12)
<223> Thr, or an amino acid selected from the group consisting of Ser,
      Asn, Ala, Ile, Leu, Val, dehydroalanine, aminoisobutyric acid,
      Asp, Glu, Lys, Met, His, Pro, Gln, Arg, Ser, Nva or Nle 

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 74
Xaa Asp Cys Xaa Leu Xaa Arg Pro Xaa Xaa Lys Xaa 
1               5                   10              


<210> 75
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Phe, or an amino acid selected from the group consisting of Ala,
      Ile, Leu, Val, dehydroalanine, aminoisobutyric acid, and/or Trp,
      Tyr, Met, Ile, Leu, and/or Ser, Asn, Cys, Gln, Thr, Asp, Glu, 
      Arg, His, Lys, Pro, and/or Nva or Nle, and/or tert-butylglycine,

<220>
<221> MOD_RES
<222> (4)..(4)
<223> continued from above; phenylglycine, 7-azatryptophan, 
      4-fluorophenylalanine, N-methyl-methionine, N-methyl-valine, 
      N-methyl-alanine, sarcosine, N-methyl-tert-butylglycine, 
      N-methyl-leucine, N-methyl-phenylglycine, N-methyl-isoleucine, 

<220>
<221> MOD_RES
<222> (4)..(4)
<223> continued from above; N-methyl-tryptophan, N-methyl-7-
      azatryptophan, N-methyl-phenylalanine, N-methyl-4-
      fluorophenylalanine, N-methyl-threonine, N-methyl-tyrosine, 
      N-methyl-valine, and N-methyl-lysine, 

<220>
<221> MOD_RES
<222> (4)..(4)
<223> continued from above; and/or a D-enantiomer of any of the 
      foregoing

<220>
<221> MOD_RES
<222> (9)..(9)
<223> Thr, or an amino acid selected from the group consisting of Ser,
      Asn, Ala, Ile, Leu, Val, dehydroalanine, aminoisobutyric acid,
      Asp, Glu, Lys, Met, His, Pro, Gln, Arg, Ser, Nva or Nle 

<220>
<221> MOD_RES
<222> (10)..(10)
<223> Glu, Ala, dehydroalanine, aminoisobutyric acid, Asp, Lys, 
      Gln, Gly, His, Arg, Asn, Met, Pro, Ser, Thr, Nva or Nle 

<220>
<221> MOD_RES
<222> (12)..(12)
<223> Thr, or an amino acid selected from the group consisting of Ser,
      Asn, Ala, Ile, Leu, Val, dehydroalanine, aminoisobutyric acid,
      Asp, Glu, Lys, Met, His, Pro, Gln, Arg, Ser, Nva or Nle 

<400> 75
Ile Asp Cys Xaa Ile Ser Arg Pro Xaa Xaa Lys Xaa 
1               5                   10              


<210> 76
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Ile, Val, Leu, Ala, Met, and/or Phe or an amino acid selected
      from the group consisting of Ile, Leu, Met, Phe, Thr, Cys, Tyr,
      dehydroalanine, aminoisobutyric acid, Nva, Nle, 
      tert-butylglycine, phenylglycine, 7-azatryptophan, 

<220>
<221> MOD_RES
<222> (1)..(1)
<223> continued from above; 4-fluorophenylalanine, N-methyl-methionine, 
      N-methyl-valine, N-methyl-alanine, sarcosine, N-methyl-tert-
      butylglycine, N-methyl-leucine, N-methyl-phenylglycine, N-methyl-
      isoleucine, N-methyl-tryptophan, N-methyl-7-azatryptophan, 

<220>
<221> MOD_RES
<222> (1)..(1)
<223> continued from above; N-methyl-phenylalanine, N-methyl-4-
      fluorophenylalanine, N-methyl-threonine, N-methyl-tyrosine, 
      N-methyl-valine, and N-methyl-lysine, and/or a D-enantiomer of 
      any of the foregoing

<220>
<221> MOD_RES
<222> (4)..(4)
<223> Phe, or an amino acid selected from the group consisting of Ala,
      Ile, Leu, Val, dehydroalanine, aminoisobutyric acid, and/or Trp,
      Tyr, Met, Ile, Leu, and/or Ser, Asn, Cys, Gln, Thr, Asp, Glu, 
      Arg, His, Lys, Pro, and/or Nva or Nle, and/or tert-butylglycine,

<220>
<221> MOD_RES
<222> (4)..(4)
<223> continued from above; phenylglycine, 7-azatryptophan, 
      4-fluorophenylalanine, N-methyl-methionine, N-methyl-valine, 
      N-methyl-alanine, sarcosine, N-methyl-tert-butylglycine, 
      N-methyl-leucine, N-methyl-phenylglycine, N-methyl-isoleucine, 

<220>
<221> MOD_RES
<222> (4)..(4)
<223> continued from above; N-methyl-tryptophan, N-methyl-7-
      azatryptophan, N-methyl-phenylalanine, N-methyl-4-
      fluorophenylalanine, N-methyl-threonine, N-methyl-tyrosine, 
      N-methyl-valine, and N-methyl-lysine, 

<220>
<221> MOD_RES
<222> (4)..(4)
<223> continued from above; and/or a D-enantiomer of any of the 
      foregoing

<220>
<221> MOD_RES
<222> (6)..(6)
<223> Ser, Ala or an amino acid selected from the group consisting
      of Asn, Thr, Cys, Gly, Asp, Glu, Lys, Gln, Gly, Pro, His or
      Arg 

<220>
<221> MOD_RES
<222> (9)..(9)
<223> Thr, or an amino acid selected from the group consisting of Ser,
      Asn, Ala, Ile, Leu, Val, dehydroalanine, aminoisobutyric acid,
      Asp, Glu, Lys, Met, His, Pro, Gln, Arg, Ser, Nva or Nle 

<220>
<221> MOD_RES
<222> (10)..(10)
<223> Glu, Ala, dehydroalanine, aminoisobutyric acid, Asp, Lys, 
      Gln, Gly, His, Arg, Asn, Met, Pro, Ser, Thr, Nva or Nle 

<220>
<221> MOD_RES
<222> (12)..(12)
<223> Thr, or an amino acid selected from the group consisting of Ser,
      Asn, Ala, Ile, Leu, Val, dehydroalanine, aminoisobutyric acid,
      Asp, Glu, Lys, Met, His, Pro, Gln, Arg, Ser, Nva or Nle 

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 76
Xaa Asp Cys Xaa Ile Xaa Arg Pro Xaa Xaa Lys Xaa 
1               5                   10              


<210> 77
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 77
Ser Arg Pro Thr Glu Lys Thr 
1               5           


<210> 78
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 78
Val Ala Cys Phe Leu Ser Arg Pro Thr Glu Lys Thr 
1               5                   10          


<210> 79
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 79
Val Asp Ala Phe Leu Ser Arg Pro Thr Glu Lys Thr 
1               5                   10          


<210> 80
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 80
Val Asp Cys Phe Ala Ser Arg Pro Thr Glu Lys Thr 
1               5                   10          


<210> 81
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 81
Val Asp Cys Phe Leu Ser Ala Pro Thr Glu Lys Thr 
1               5                   10          


<210> 82
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 82
Val Asp Cys Phe Leu Ser Arg Ala Thr Glu Lys Thr 
1               5                   10          


<210> 83
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 83
Val Asp Cys Phe Leu Ser Arg Pro Thr Ala Lys Thr 
1               5                   10          


<210> 84
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 84
Val Asp Cys Phe Leu Ser Arg Pro Thr Glu Ala Thr 
1               5                   10          


<210> 85
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 85
Cys Phe Leu Ser Arg Pro Thr Glu Lys Thr 
1               5                   10  


<210> 86
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 86
Leu Ser Arg Pro Thr Glu Lys Thr 
1               5               


<210> 87
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 87
Val Asp Cys Phe Leu Ser Arg Pro Thr Glu 
1               5                   10  


<210> 88
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 88
Val Asp Cys Phe Leu Ser Arg Pro 
1               5               


<210> 89
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 89
Val Asp Cys Phe Leu Ser 
1               5       


<210> 90
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 90
Arg Phe Lys Pro Ser Leu Cys Thr Thr Asp Glu Val 
1               5                   10          


<210> 91
<211> 35
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 91
Glu Ser Ala Trp Gly Asp Glu Gln Ser Ala Phe Arg Cys Asn Thr Gln 
1               5                   10                  15      


Gln Pro Gly Cys Glu Asn Val Cys Tyr Asp Lys Ser Phe Pro Ile Ser 
            20                  25                  30          


His Val Arg 
        35  


<210> 92
<211> 34
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 92
Gln Trp Tyr Ile Tyr Gly Phe Ser Leu Ser Ala Val Tyr Thr Cys Lys 
1               5                   10                  15      


Arg Asp Pro Cys Pro His Gln Val Asp Cys Phe Leu Ser Arg Pro Thr 
            20                  25                  30          


Glu Lys 
        


<210> 93
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 93
Glu Ser Ala Trp Gly Asp Glu Gln Ser Ala Phe Arg Cys Asn Thr Gln 
1               5                   10                  15      


Gln 
    


<210> 94
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 94
Pro Gly Cys Glu Asn Val Cys Tyr Asp Lys Ser Phe Pro Ile Ser His 
1               5                   10                  15      


Val Arg 
        


<210> 95
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 95
Ala Phe Arg Cys Asn Thr Gln Gln Pro Gly Cys Glu Asn Val Cys Tyr 
1               5                   10                  15      


Asp 
    


<210> 96
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 96
Phe Leu Leu Ile Gln Trp Tyr Ile Tyr Gly Phe Ser Leu Ser Ala Val 
1               5                   10                  15      


Tyr Thr Cys 
            


<210> 97
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 97
Lys Arg Asp Pro Cys Pro His Gln Val Asp Cys Phe Leu Ser Arg Pro 
1               5                   10                  15      


Thr Glu Lys Thr 
            20  


<210> 98
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 98
Gly Phe Ser Leu Ser Ala Val Tyr Thr Cys Lys Arg Asp Pro Cys Pro 
1               5                   10                  15      


His Gln Val Asp 
            20  



