                         SEQUENCE LISTING

<110>  Pioneer Hi-Bred International, Inc.
       E I du Pont de Nemours and Company
       Barry, Jennifer Kara
       Bartholomay, Christian
       D'Lima, Louisa
       English, James J
       Hayes, Kevin Robert
       Lum, Amy
       Liu, Lu
       Poland, Brad
       Scheppers, Eric Jude
       Xie, Weiping
       Yalpani, Nasser
       Zhu, Genhai
 
<120>  INSECTICIDAL PROTEINS AND METHODS FOR THEIR USE

<130>  6441-WO-PCT

<150>  62/331708
<151>  2016-05-04

<160>  388   

<170>  PatentIn version 3.5

<210>  1
<211>  1449
<212>  DNA
<213>  Pseudomonas sp

<400>  1
atggaaaaca tagacttgcc acaaggactt gtaaactttt ccacgcaaca cctgcaactt       60
attcgtttta aagcaggttt gaatgaaacc gtactacctg gcgtcgaagc cattggactt      120
ggctataacc cattcatcag ttatgccagt gtcaacagcg gcgcggtgca attgttcgac      180
tgggccacgg ccaagaaacg cgaagtgcct ttcaaagccg gctacttcgt acccgagatc      240
gtcgacgtgc aacagaacga cagcgcaacc tacaccaacg tcagcggcaa cacgatcagc      300
gagtaccagc gcagtctggc taccagcgtc gccatcgaag gccgttacaa cttcttcagt      360
ggctcgctgt ccacggattt cgacagtaat tcactgcgca acgcggaaaa cgagttcact      420
cgcattcagc aatcgatcaa cctctggtcg ttgcgcttgc cttcggtgaa gtcattgcgc      480
gaactgatgc tgccacacat gcgccaacaa ctagatgaat tgaacgtcaa cgacccgaag      540
gccataagcc gctatttcga tagagttggc agccatttcc ttaccggcat cgtaatgggt      600
ggacgggcca tcctcgcctc ctcgaccaac aagctcaggg tcaagcgtga ctactcggtg      660
tcggtggtcg ccaaggcgag ctacgaaggg cttaccggcc agttgagcgc agaagccaaa      720
gccaagtatg gcgagtcgat cagcagcttc actcagtact ccaataccca ccaggaagtg      780
cgcggcggcg acggtgccaa ggcacatggg gtgttcagcg gcaaaaaaga agatttccag      840
gcctgggtag acagtgtgag cgcctcgccg gacttcgtcg atttcgtccc caccatcccc      900
atgcaggaaa tctggaccct gtgcagcagc gaggcgcagg ccgaggccat gcgcaagcat      960
tacgatgacg tctgggcgcc ggcgcaatcg gaaaagtacc gggtcaaggc taactacatc     1020
gaccaactgg tggtcatcac cggcggtagt tcaaccatcg aaccaccggt cggctacagc     1080
aagatcgagt acgacctcaa tgccggtgcc ggcggtgact tcatctactt gtgctatcac     1140
gaacaaacct ggcaggccga caggcctaaa gatgctgtga cggatatcag gatcattttc     1200
aacaaggagc ctaccccacc tggctatacc aagctgcccc aggacctgaa caagggcgcg     1260
ggcggtgatg atgtattcct ctgctacaag accgaggctt acaacaccga caccgcaatc     1320
aacaaggtca cggtcatcgg cggcaacaat gcggatatca acgctcccta tggttatctg     1380
aaggtccccg gtgacctcaa cagaggtgct ggcggcaact tcatctatgc ctgtaccttc     1440
gtaggcaag                                                             1449

<210>  2
<211>  483
<212>  PRT
<213>  Pseudomonas sp

<400>  2
Met Glu Asn Ile Asp Leu Pro Gln Gly Leu Val Asn Phe Ser Thr Gln 
1               5                   10                  15      
His Leu Gln Leu Ile Arg Phe Lys Ala Gly Leu Asn Glu Thr Val Leu 
            20                  25                  30          
Pro Gly Val Glu Ala Ile Gly Leu Gly Tyr Asn Pro Phe Ile Ser Tyr 
        35                  40                  45              
Ala Ser Val Asn Ser Gly Ala Val Gln Leu Phe Asp Trp Ala Thr Ala 
    50                  55                  60                  
Lys Lys Arg Glu Val Pro Phe Lys Ala Gly Tyr Phe Val Pro Glu Ile 
65                  70                  75                  80  
Val Asp Val Gln Gln Asn Asp Ser Ala Thr Tyr Thr Asn Val Ser Gly 
                85                  90                  95      
Asn Thr Ile Ser Glu Tyr Gln Arg Ser Leu Ala Thr Ser Val Ala Ile 
            100                 105                 110         
Glu Gly Arg Tyr Asn Phe Phe Ser Gly Ser Leu Ser Thr Asp Phe Asp 
        115                 120                 125             
Ser Asn Ser Leu Arg Asn Ala Glu Asn Glu Phe Thr Arg Ile Gln Gln 
    130                 135                 140                 
Ser Ile Asn Leu Trp Ser Leu Arg Leu Pro Ser Val Lys Ser Leu Arg 
145                 150                 155                 160 
Glu Leu Met Leu Pro His Met Arg Gln Gln Leu Asp Glu Leu Asn Val 
                165                 170                 175     
Asn Asp Pro Lys Ala Ile Ser Arg Tyr Phe Asp Arg Val Gly Ser His 
            180                 185                 190         
Phe Leu Thr Gly Ile Val Met Gly Gly Arg Ala Ile Leu Ala Ser Ser 
        195                 200                 205             
Thr Asn Lys Leu Arg Val Lys Arg Asp Tyr Ser Val Ser Val Val Ala 
    210                 215                 220                 
Lys Ala Ser Tyr Glu Gly Leu Thr Gly Gln Leu Ser Ala Glu Ala Lys 
225                 230                 235                 240 
Ala Lys Tyr Gly Glu Ser Ile Ser Ser Phe Thr Gln Tyr Ser Asn Thr 
                245                 250                 255     
His Gln Glu Val Arg Gly Gly Asp Gly Ala Lys Ala His Gly Val Phe 
            260                 265                 270         
Ser Gly Lys Lys Glu Asp Phe Gln Ala Trp Val Asp Ser Val Ser Ala 
        275                 280                 285             
Ser Pro Asp Phe Val Asp Phe Val Pro Thr Ile Pro Met Gln Glu Ile 
    290                 295                 300                 
Trp Thr Leu Cys Ser Ser Glu Ala Gln Ala Glu Ala Met Arg Lys His 
305                 310                 315                 320 
Tyr Asp Asp Val Trp Ala Pro Ala Gln Ser Glu Lys Tyr Arg Val Lys 
                325                 330                 335     
Ala Asn Tyr Ile Asp Gln Leu Val Val Ile Thr Gly Gly Ser Ser Thr 
            340                 345                 350         
Ile Glu Pro Pro Val Gly Tyr Ser Lys Ile Glu Tyr Asp Leu Asn Ala 
        355                 360                 365             
Gly Ala Gly Gly Asp Phe Ile Tyr Leu Cys Tyr His Glu Gln Thr Trp 
    370                 375                 380                 
Gln Ala Asp Arg Pro Lys Asp Ala Val Thr Asp Ile Arg Ile Ile Phe 
385                 390                 395                 400 
Asn Lys Glu Pro Thr Pro Pro Gly Tyr Thr Lys Leu Pro Gln Asp Leu 
                405                 410                 415     
Asn Lys Gly Ala Gly Gly Asp Asp Val Phe Leu Cys Tyr Lys Thr Glu 
            420                 425                 430         
Ala Tyr Asn Thr Asp Thr Ala Ile Asn Lys Val Thr Val Ile Gly Gly 
        435                 440                 445             
Asn Asn Ala Asp Ile Asn Ala Pro Tyr Gly Tyr Leu Lys Val Pro Gly 
    450                 455                 460                 
Asp Leu Asn Arg Gly Ala Gly Gly Asn Phe Ile Tyr Ala Cys Thr Phe 
465                 470                 475                 480 
Val Gly Lys 
            

<210>  3
<211>  1449
<212>  DNA
<213>  Pseudomonas monteilii

<400>  3
atggaaaaca tagacttgcc acaaggactt gtaaactttt ccacgcaaca cctgcaactt       60
attcgtttta aagcaggttt gaatgaaacc gtactacctg gcgtcgaagc cattggactt      120
ggctataacc cattcatcag ttatgccagt gtcaacagcg gcgcggtgca attgttcgac      180
tgggccacgg ccaagaaacg cgaagtgcct ttcaaagccg gctacttcgt acccgagatc      240
gtcgacgtgc aacagaacga cagcgcaacc tacaccaacg tcagcggcaa cacgatcagc      300
gagtaccagc gcagtctggc taccagcgtc gccatcgaag gccgttacaa cttcttcagt      360
ggctcgctgt ccacggattt cgacagtaat tcactgcgca acgcggaaaa cgagttcact      420
cgcattcagc aatcgatcaa cctctggtcg ttgcgcttgc cttcggtgaa gtcattgcgc      480
gaactgatgc tgccacacat gcgccaacaa ctagatgaat tgaacgtcaa cgacccgaag      540
gccataagcc gctatttcga tagagttggc agccatttcc ttaccggcat cgtaatgggt      600
ggacgggcca tcctcgcctc ctcgaccaac aagctcaggg tcaagcgtga ctactcggtg      660
tcggtggtcg ccaaggcgag ctacgaaggg cttaccggcc agttgagcgc agaagccaaa      720
gccaagtatg gcgagtcgat cagcagcttc actcagtact ccaataccca ccaggaagtg      780
cgcggcggcg acggtgccaa ggcacatggg gtgttcagcg gcaaaaaaga agatttccag      840
gcctgggtag acagtgtgag cgcctcgccg gacttcgtcg atttcgtccc caccatcccc      900
atgcaggaaa tctggaccct gtgcagcagc gaggcgcagg ccgaggccat gcgcaagcat      960
tacgatgacg tctgggcgcc ggcgcaatcg gaaaagtacc gggtcaaggc taactacatc     1020
gaccaactgg tggtcatcac cggcggtagt tcaaccatcg aaccaccggt cggctacagc     1080
aagatcgagt acgacctcaa tgccggtgcc ggcggtgact tcatctactt gtgctatcac     1140
gaacaaacct ggcaggccga caggcctaaa gatgctgtga cggatatcag gatcattttc     1200
aacaaggagc ctaccccacc tggctatacc aagctgcccc aggacctgaa caagagcgcg     1260
ggcggtgatg atgtattcct ctgctacaag accgaggctt acaacaccga caccgcaatc     1320
aacaaggtca cggtcatcgg cggcaacaat gcggatatca acgctcccta tggttatctg     1380
aaggtccccg gtgacctcaa cagaggtgct ggcggcaact tcatctatgc ctgtaccttc     1440
gtaggcaag                                                             1449

<210>  4
<211>  483
<212>  PRT
<213>  Pseudomonas monteilii

<400>  4
Met Glu Asn Ile Asp Leu Pro Gln Gly Leu Val Asn Phe Ser Thr Gln 
1               5                   10                  15      
His Leu Gln Leu Ile Arg Phe Lys Ala Gly Leu Asn Glu Thr Val Leu 
            20                  25                  30          
Pro Gly Val Glu Ala Ile Gly Leu Gly Tyr Asn Pro Phe Ile Ser Tyr 
        35                  40                  45              
Ala Ser Val Asn Ser Gly Ala Val Gln Leu Phe Asp Trp Ala Thr Ala 
    50                  55                  60                  
Lys Lys Arg Glu Val Pro Phe Lys Ala Gly Tyr Phe Val Pro Glu Ile 
65                  70                  75                  80  
Val Asp Val Gln Gln Asn Asp Ser Ala Thr Tyr Thr Asn Val Ser Gly 
                85                  90                  95      
Asn Thr Ile Ser Glu Tyr Gln Arg Ser Leu Ala Thr Ser Val Ala Ile 
            100                 105                 110         
Glu Gly Arg Tyr Asn Phe Phe Ser Gly Ser Leu Ser Thr Asp Phe Asp 
        115                 120                 125             
Ser Asn Ser Leu Arg Asn Ala Glu Asn Glu Phe Thr Arg Ile Gln Gln 
    130                 135                 140                 
Ser Ile Asn Leu Trp Ser Leu Arg Leu Pro Ser Val Lys Ser Leu Arg 
145                 150                 155                 160 
Glu Leu Met Leu Pro His Met Arg Gln Gln Leu Asp Glu Leu Asn Val 
                165                 170                 175     
Asn Asp Pro Lys Ala Ile Ser Arg Tyr Phe Asp Arg Val Gly Ser His 
            180                 185                 190         
Phe Leu Thr Gly Ile Val Met Gly Gly Arg Ala Ile Leu Ala Ser Ser 
        195                 200                 205             
Thr Asn Lys Leu Arg Val Lys Arg Asp Tyr Ser Val Ser Val Val Ala 
    210                 215                 220                 
Lys Ala Ser Tyr Glu Gly Leu Thr Gly Gln Leu Ser Ala Glu Ala Lys 
225                 230                 235                 240 
Ala Lys Tyr Gly Glu Ser Ile Ser Ser Phe Thr Gln Tyr Ser Asn Thr 
                245                 250                 255     
His Gln Glu Val Arg Gly Gly Asp Gly Ala Lys Ala His Gly Val Phe 
            260                 265                 270         
Ser Gly Lys Lys Glu Asp Phe Gln Ala Trp Val Asp Ser Val Ser Ala 
        275                 280                 285             
Ser Pro Asp Phe Val Asp Phe Val Pro Thr Ile Pro Met Gln Glu Ile 
    290                 295                 300                 
Trp Thr Leu Cys Ser Ser Glu Ala Gln Ala Glu Ala Met Arg Lys His 
305                 310                 315                 320 
Tyr Asp Asp Val Trp Ala Pro Ala Gln Ser Glu Lys Tyr Arg Val Lys 
                325                 330                 335     
Ala Asn Tyr Ile Asp Gln Leu Val Val Ile Thr Gly Gly Ser Ser Thr 
            340                 345                 350         
Ile Glu Pro Pro Val Gly Tyr Ser Lys Ile Glu Tyr Asp Leu Asn Ala 
        355                 360                 365             
Gly Ala Gly Gly Asp Phe Ile Tyr Leu Cys Tyr His Glu Gln Thr Trp 
    370                 375                 380                 
Gln Ala Asp Arg Pro Lys Asp Ala Val Thr Asp Ile Arg Ile Ile Phe 
385                 390                 395                 400 
Asn Lys Glu Pro Thr Pro Pro Gly Tyr Thr Lys Leu Pro Gln Asp Leu 
                405                 410                 415     
Asn Lys Ser Ala Gly Gly Asp Asp Val Phe Leu Cys Tyr Lys Thr Glu 
            420                 425                 430         
Ala Tyr Asn Thr Asp Thr Ala Ile Asn Lys Val Thr Val Ile Gly Gly 
        435                 440                 445             
Asn Asn Ala Asp Ile Asn Ala Pro Tyr Gly Tyr Leu Lys Val Pro Gly 
    450                 455                 460                 
Asp Leu Asn Arg Gly Ala Gly Gly Asn Phe Ile Tyr Ala Cys Thr Phe 
465                 470                 475                 480 
Val Gly Lys 
            

<210>  5
<211>  1449
<212>  DNA
<213>  Pseudomonas entomophila

<400>  5
atggaacacg tcgacctgcc gacgggactc gtcaaatttt ccagcaatca ccatctgcaa       60
ttgctgcgcg acaccgccga cctcagtgaa tcagtgcttc cgggcgtaga ggccattggc      120
ttgggataca acccattcct cggctacgcc ggtgtgggaa gcggcaccgt ccagcttttc      180
gactggaaca acgcaaaaaa gaaaaaagtg tcattcaaac ccgagttcgt cgtgccggag      240
atcgtcgacg tccagcagaa tgacagcgcc agctacacca acatcagtgg caacaccgtc      300
accgagtatc aacgcagcct ggccgtcagc gtggccatcg aaggcaaata caacttcttc      360
agtggttcgc tttcaaccga ctacgacgaa aactcgctgc gtaatgccga gaacgagttc      420
acccgtatcc agcaatcgat caacctctgg tcgctgcgcc tgccttcggt caaatcactg      480
cgcgacctga tgctgccgca catgcgtgag caactggatg agctggacgt gaaaaacccg      540
agtgccatca gccggttctt cgaccgggtg ggcagccact tcctcaccgg catcgtgatg      600
ggcggccgag ccatactcgc cgcctcgacc aacaaactga aggtcaagcg cgactactcc      660
gtgtcggtca tcgccaaggc gagctacgaa ggcttgaccg gccagctgag cgccgaggcc      720
aggaccaagt acggcgaatc catgagcagt ttcacccagt actccagcac ccaccaggaa      780
gtccgtggcg gcgatggcac caaggcccat ggtgtgttcg agggcaaggc cgggttccag      840
gcctgggtcg acagcgtggg gacctcgccc gatttcgtcg acttcgtgcc caccatcccg      900
atgctggaga tctggagcct gtgcaagacc gattcacagg ctgaagccat gaagcgccat      960
ttcgacacgg tctgggcccg cgaacaatcg gacaagtacc ggataaaggc gaactacatc     1020
gatcagctgg tggtaatcac cggtgacagt tcgaccatcg aacctccggc tggctatacc     1080
aagattccct acgacctcaa tgccggggcc aagggcgact tcatctattt gtgctaccac     1140
gaacaagcgt ggtatcccga caacaccaaa cctgccgtca ccgcgatcaa gatcatctac     1200
gaccgggaac cggtacccac cgggtatatc aagctgccgc aagacctcaa caaaggcgca     1260
ggtggcgcgg acatctacct ttgctacaag ctcgagggct acaacaccga taccgcgatc     1320
aacaagatca ccgtgatcag cgggaacaac cccgacatta acgcccccta tggctatgag     1380
aaagtgccgg gcgacctgaa caagggcgca aaaggcaact tcatctatgc ctgcactttc     1440
gtcggcaag                                                             1449

<210>  6
<211>  483
<212>  PRT
<213>  Pseudomonas entomophila

<400>  6
Met Glu His Val Asp Leu Pro Thr Gly Leu Val Lys Phe Ser Ser Asn 
1               5                   10                  15      
His His Leu Gln Leu Leu Arg Asp Thr Ala Asp Leu Ser Glu Ser Val 
            20                  25                  30          
Leu Pro Gly Val Glu Ala Ile Gly Leu Gly Tyr Asn Pro Phe Leu Gly 
        35                  40                  45              
Tyr Ala Gly Val Gly Ser Gly Thr Val Gln Leu Phe Asp Trp Asn Asn 
    50                  55                  60                  
Ala Lys Lys Lys Lys Val Ser Phe Lys Pro Glu Phe Val Val Pro Glu 
65                  70                  75                  80  
Ile Val Asp Val Gln Gln Asn Asp Ser Ala Ser Tyr Thr Asn Ile Ser 
                85                  90                  95      
Gly Asn Thr Val Thr Glu Tyr Gln Arg Ser Leu Ala Val Ser Val Ala 
            100                 105                 110         
Ile Glu Gly Lys Tyr Asn Phe Phe Ser Gly Ser Leu Ser Thr Asp Tyr 
        115                 120                 125             
Asp Glu Asn Ser Leu Arg Asn Ala Glu Asn Glu Phe Thr Arg Ile Gln 
    130                 135                 140                 
Gln Ser Ile Asn Leu Trp Ser Leu Arg Leu Pro Ser Val Lys Ser Leu 
145                 150                 155                 160 
Arg Asp Leu Met Leu Pro His Met Arg Glu Gln Leu Asp Glu Leu Asp 
                165                 170                 175     
Val Lys Asn Pro Ser Ala Ile Ser Arg Phe Phe Asp Arg Val Gly Ser 
            180                 185                 190         
His Phe Leu Thr Gly Ile Val Met Gly Gly Arg Ala Ile Leu Ala Ala 
        195                 200                 205             
Ser Thr Asn Lys Leu Lys Val Lys Arg Asp Tyr Ser Val Ser Val Ile 
    210                 215                 220                 
Ala Lys Ala Ser Tyr Glu Gly Leu Thr Gly Gln Leu Ser Ala Glu Ala 
225                 230                 235                 240 
Arg Thr Lys Tyr Gly Glu Ser Met Ser Ser Phe Thr Gln Tyr Ser Ser 
                245                 250                 255     
Thr His Gln Glu Val Arg Gly Gly Asp Gly Thr Lys Ala His Gly Val 
            260                 265                 270         
Phe Glu Gly Lys Ala Gly Phe Gln Ala Trp Val Asp Ser Val Gly Thr 
        275                 280                 285             
Ser Pro Asp Phe Val Asp Phe Val Pro Thr Ile Pro Met Leu Glu Ile 
    290                 295                 300                 
Trp Ser Leu Cys Lys Thr Asp Ser Gln Ala Glu Ala Met Lys Arg His 
305                 310                 315                 320 
Phe Asp Thr Val Trp Ala Arg Glu Gln Ser Asp Lys Tyr Arg Ile Lys 
                325                 330                 335     
Ala Asn Tyr Ile Asp Gln Leu Val Val Ile Thr Gly Asp Ser Ser Thr 
            340                 345                 350         
Ile Glu Pro Pro Ala Gly Tyr Thr Lys Ile Pro Tyr Asp Leu Asn Ala 
        355                 360                 365             
Gly Ala Lys Gly Asp Phe Ile Tyr Leu Cys Tyr His Glu Gln Ala Trp 
    370                 375                 380                 
Tyr Pro Asp Asn Thr Lys Pro Ala Val Thr Ala Ile Lys Ile Ile Tyr 
385                 390                 395                 400 
Asp Arg Glu Pro Val Pro Thr Gly Tyr Ile Lys Leu Pro Gln Asp Leu 
                405                 410                 415     
Asn Lys Gly Ala Gly Gly Ala Asp Ile Tyr Leu Cys Tyr Lys Leu Glu 
            420                 425                 430         
Gly Tyr Asn Thr Asp Thr Ala Ile Asn Lys Ile Thr Val Ile Ser Gly 
        435                 440                 445             
Asn Asn Pro Asp Ile Asn Ala Pro Tyr Gly Tyr Glu Lys Val Pro Gly 
    450                 455                 460                 
Asp Leu Asn Lys Gly Ala Lys Gly Asn Phe Ile Tyr Ala Cys Thr Phe 
465                 470                 475                 480 
Val Gly Lys 
            

<210>  7
<211>  1470
<212>  DNA
<213>  Woodshole amaritima

<400>  7
atgaaaagcc tggaccatgt ggcacaccag aacctgctga atgaaccgac ccatcataag       60
agcaacacca aagcggcgct gatgcgccac caggaaaacc tggtggaacg ctatctgcct      120
ggtgttgaag tgatcggcgc cggttacaac ccgttcggtg tctacgctag cacggattcc      180
gtaactgtac agctgttcga ctggcagtct gcgccgtctg aaccggttat cttcaacccg      240
gactacatcg caccaaaagc ggtgtctgtg cagcagaacg acgaagcccg ttacactaac      300
gtctccggta agactatcaa cacgtttcag aaaaacttca gcctgaaagt gacggtggct      360
ggttcttaca acctgttcag cggttctgtg agcaacgaat tcagctcttc tgaaactcgt      420
aacgctgaga acgaattctc ccgtatccag cagagcatcc gtgtttggtc cctgcgtctg      480
gcgtatactg acagcctgcg cgaatacctg aaagcggacg tacgtgacta catcgacagc      540
attcaatccg atgcgcagat cgaaatcctg ttcgatcgtt acggctctca tttcctgacc      600
ggtgtagtta tgggcggtgc agctatcatg gcgagctcca ccaacaaagt gcaggtggac      660
cacacttatg aaaacgaaac catcgccaaa gcgtcttacg aagctctgac cggtcagatc      720
agcgctgaaa ccgctgcgaa ataccgtcag tctatgagct ctttctctca aaactccgac      780
atccacaaga tcgttgttgg tggcgatggt gttgctggtg ctaaagtgta ctctggtgat      840
aaagctgatt ttgatgcgtg ggccgatacc gtcggtacca gcccggattt tgtagatttt      900
gtttcctccg tgccgatgct gggtatctgg gagctgtgta aagatgatgc ccaggcaaag      960
aaaatggagg actattacaa caacacctgg gcgccacgca agagcaaaga agcgcaaatc     1020
tacgcggact acatcgatgc agtcgaagtg atccagtcca attccagcgg tgttcgccca     1080
ccgagcggct acacgaaaat cgattacgat ctgaacaaag gtgcaggcgg cgactacatc     1140
tacctgtgct accataaagc tcgctactct gcttactctg aaaacaaaga ttgcgtttct     1200
gacctgatca tcatcaaagg taacggtgcg cgcgctccaa gcggttacac taaaattgat     1260
gtggacctga acgaagatgc cggcggcaag tatctgtatc tgtgttataa aaaacagtct     1320
tacgataacg ttgaagcgat taaaggcctg gctgtggtag gcggcgacaa ctctcacact     1380
ccggctccgt acggctaccg ccgtattgac accgatgtaa acgagggtgc tggtggcgaa     1440
tatatttata tttgctattc caaaggcgcc                                      1470

<210>  8
<211>  490
<212>  PRT
<213>  Woodshole amaritima

<400>  8
Met Lys Ser Leu Asp His Val Ala His Gln Asn Leu Leu Asn Glu Pro 
1               5                   10                  15      
Thr His His Lys Ser Asn Thr Lys Ala Ala Leu Met Arg His Gln Glu 
            20                  25                  30          
Asn Leu Val Glu Arg Tyr Leu Pro Gly Val Glu Val Ile Gly Ala Gly 
        35                  40                  45              
Tyr Asn Pro Phe Gly Val Tyr Ala Ser Thr Asp Ser Val Thr Val Gln 
    50                  55                  60                  
Leu Phe Asp Trp Gln Ser Ala Pro Ser Glu Pro Val Ile Phe Asn Pro 
65                  70                  75                  80  
Asp Tyr Ile Ala Pro Lys Ala Val Ser Val Gln Gln Asn Asp Glu Ala 
                85                  90                  95      
Arg Tyr Thr Asn Val Ser Gly Lys Thr Ile Asn Thr Phe Gln Lys Asn 
            100                 105                 110         
Phe Ser Leu Lys Val Thr Val Ala Gly Ser Tyr Asn Leu Phe Ser Gly 
        115                 120                 125             
Ser Val Ser Asn Glu Phe Ser Ser Ser Glu Thr Arg Asn Ala Glu Asn 
    130                 135                 140                 
Glu Phe Ser Arg Ile Gln Gln Ser Ile Arg Val Trp Ser Leu Arg Leu 
145                 150                 155                 160 
Ala Tyr Thr Asp Ser Leu Arg Glu Tyr Leu Lys Ala Asp Val Arg Asp 
                165                 170                 175     
Tyr Ile Asp Ser Ile Gln Ser Asp Ala Gln Ile Glu Ile Leu Phe Asp 
            180                 185                 190         
Arg Tyr Gly Ser His Phe Leu Thr Gly Val Val Met Gly Gly Ala Ala 
        195                 200                 205             
Ile Met Ala Ser Ser Thr Asn Lys Val Gln Val Asp His Thr Tyr Glu 
    210                 215                 220                 
Asn Glu Thr Ile Ala Lys Ala Ser Tyr Glu Ala Leu Thr Gly Gln Ile 
225                 230                 235                 240 
Ser Ala Glu Thr Ala Ala Lys Tyr Arg Gln Ser Met Ser Ser Phe Ser 
                245                 250                 255     
Gln Asn Ser Asp Ile His Lys Ile Val Val Gly Gly Asp Gly Val Ala 
            260                 265                 270         
Gly Ala Lys Val Tyr Ser Gly Asp Lys Ala Asp Phe Asp Ala Trp Ala 
        275                 280                 285             
Asp Thr Val Gly Thr Ser Pro Asp Phe Val Asp Phe Val Ser Ser Val 
    290                 295                 300                 
Pro Met Leu Gly Ile Trp Glu Leu Cys Lys Asp Asp Ala Gln Ala Lys 
305                 310                 315                 320 
Lys Met Glu Asp Tyr Tyr Asn Asn Thr Trp Ala Pro Arg Lys Ser Lys 
                325                 330                 335     
Glu Ala Gln Ile Tyr Ala Asp Tyr Ile Asp Ala Val Glu Val Ile Gln 
            340                 345                 350         
Ser Asn Ser Ser Gly Val Arg Pro Pro Ser Gly Tyr Thr Lys Ile Asp 
        355                 360                 365             
Tyr Asp Leu Asn Lys Gly Ala Gly Gly Asp Tyr Ile Tyr Leu Cys Tyr 
    370                 375                 380                 
His Lys Ala Arg Tyr Ser Ala Tyr Ser Glu Asn Lys Asp Cys Val Ser 
385                 390                 395                 400 
Asp Leu Ile Ile Ile Lys Gly Asn Gly Ala Arg Ala Pro Ser Gly Tyr 
                405                 410                 415     
Thr Lys Ile Asp Val Asp Leu Asn Glu Asp Ala Gly Gly Lys Tyr Leu 
            420                 425                 430         
Tyr Leu Cys Tyr Lys Lys Gln Ser Tyr Asp Asn Val Glu Ala Ile Lys 
        435                 440                 445             
Gly Leu Ala Val Val Gly Gly Asp Asn Ser His Thr Pro Ala Pro Tyr 
    450                 455                 460                 
Gly Tyr Arg Arg Ile Asp Thr Asp Val Asn Glu Gly Ala Gly Gly Glu 
465                 470                 475                 480 
Tyr Ile Tyr Ile Cys Tyr Ser Lys Gly Ala 
                485                 490 

<210>  9
<211>  1380
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  9
atggcaggtt tgaatgaaac cgtactacct ggcgtcgaag ccattggact tggctataac       60
ccattcatca gttatgccag tgtcaacagc ggcgcggtgc aattgttcga ctgggccacg      120
gccaagaaac gcgaagtgcc tttcaaagcc ggctacttcg tacccgagat cgtcgacgtg      180
caacagaacg acagcgcaac ctacaccaac gtcagcggca acacgatcag cgagtaccag      240
cgcagtctgg ctaccagcgt cgccatcgaa ggccgttaca acttcttcag tggctcgctg      300
tccacggatt tcgacagtaa ttcactgcgc aacgcggaaa acgagttcac tcgcattcag      360
caatcgatca acctctggtc gttgcgcttg ccttcggtga agtcattgcg cgaactgatg      420
ctgccacaca tgcgccaaca actagatgaa ttgaacgtca acgacccgaa ggccataagc      480
cgctatttcg atagagttgg cagccatttc cttaccggca tcgtaatggg tggacgggcc      540
atcctcgcct cctcgaccaa caagctcagg gtcaagcgtg actactcggt gtcggtggtc      600
gccaaggcga gctacgaagg gcttaccggc cagttgagcg cagaagccaa agccaagtat      660
ggcgagtcga tcagcagctt cactcagtac tccaataccc accaggaagt gcgcggcggc      720
gacggtgcca aggcacatgg ggtgttcagc ggcaaaaaag aagatttcca ggcctgggta      780
gacagtgtga gcgcctcgcc ggacttcgtc gatttcgtcc ccaccatccc catgcaggaa      840
atctggaccc tgtgcagcag cgaggcgcag gccgaggcca tgcgcaagca ttacgatgac      900
gtctgggcgc cggcgcaatc ggaaaagtac cgggtcaagg ctaactacat cgaccaactg      960
gtggtcatca ccggcggtag ttcaaccatc gaaccaccgg tcggctacag caagatcgag     1020
tacgacctca atgccggtgc cggcggtgac ttcatctact tgtgctatca cgaacaaacc     1080
tggcaggccg acaggcctaa agatgctgtg acggatatca ggatcatttt caacaaggag     1140
cctaccccac ctggctatac caagctgccc caggacctga acaagggcgc gggcggtgat     1200
gatgtattcc tctgctacaa gaccgaggct tacaacaccg acaccgcaat caacaaggtc     1260
acggtcatcg gcggcaacaa tgcggatatc aacgctccct atggttatct gaaggtcccc     1320
ggtgacctca acagaggtgc tggcggcaac ttcatctatg cctgtacctt cgtaggcaag     1380

<210>  10
<211>  460
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  10
Met Ala Gly Leu Asn Glu Thr Val Leu Pro Gly Val Glu Ala Ile Gly 
1               5                   10                  15      
Leu Gly Tyr Asn Pro Phe Ile Ser Tyr Ala Ser Val Asn Ser Gly Ala 
            20                  25                  30          
Val Gln Leu Phe Asp Trp Ala Thr Ala Lys Lys Arg Glu Val Pro Phe 
        35                  40                  45              
Lys Ala Gly Tyr Phe Val Pro Glu Ile Val Asp Val Gln Gln Asn Asp 
    50                  55                  60                  
Ser Ala Thr Tyr Thr Asn Val Ser Gly Asn Thr Ile Ser Glu Tyr Gln 
65                  70                  75                  80  
Arg Ser Leu Ala Thr Ser Val Ala Ile Glu Gly Arg Tyr Asn Phe Phe 
                85                  90                  95      
Ser Gly Ser Leu Ser Thr Asp Phe Asp Ser Asn Ser Leu Arg Asn Ala 
            100                 105                 110         
Glu Asn Glu Phe Thr Arg Ile Gln Gln Ser Ile Asn Leu Trp Ser Leu 
        115                 120                 125             
Arg Leu Pro Ser Val Lys Ser Leu Arg Glu Leu Met Leu Pro His Met 
    130                 135                 140                 
Arg Gln Gln Leu Asp Glu Leu Asn Val Asn Asp Pro Lys Ala Ile Ser 
145                 150                 155                 160 
Arg Tyr Phe Asp Arg Val Gly Ser His Phe Leu Thr Gly Ile Val Met 
                165                 170                 175     
Gly Gly Arg Ala Ile Leu Ala Ser Ser Thr Asn Lys Leu Arg Val Lys 
            180                 185                 190         
Arg Asp Tyr Ser Val Ser Val Val Ala Lys Ala Ser Tyr Glu Gly Leu 
        195                 200                 205             
Thr Gly Gln Leu Ser Ala Glu Ala Lys Ala Lys Tyr Gly Glu Ser Ile 
    210                 215                 220                 
Ser Ser Phe Thr Gln Tyr Ser Asn Thr His Gln Glu Val Arg Gly Gly 
225                 230                 235                 240 
Asp Gly Ala Lys Ala His Gly Val Phe Ser Gly Lys Lys Glu Asp Phe 
                245                 250                 255     
Gln Ala Trp Val Asp Ser Val Ser Ala Ser Pro Asp Phe Val Asp Phe 
            260                 265                 270         
Val Pro Thr Ile Pro Met Gln Glu Ile Trp Thr Leu Cys Ser Ser Glu 
        275                 280                 285             
Ala Gln Ala Glu Ala Met Arg Lys His Tyr Asp Asp Val Trp Ala Pro 
    290                 295                 300                 
Ala Gln Ser Glu Lys Tyr Arg Val Lys Ala Asn Tyr Ile Asp Gln Leu 
305                 310                 315                 320 
Val Val Ile Thr Gly Gly Ser Ser Thr Ile Glu Pro Pro Val Gly Tyr 
                325                 330                 335     
Ser Lys Ile Glu Tyr Asp Leu Asn Ala Gly Ala Gly Gly Asp Phe Ile 
            340                 345                 350         
Tyr Leu Cys Tyr His Glu Gln Thr Trp Gln Ala Asp Arg Pro Lys Asp 
        355                 360                 365             
Ala Val Thr Asp Ile Arg Ile Ile Phe Asn Lys Glu Pro Thr Pro Pro 
    370                 375                 380                 
Gly Tyr Thr Lys Leu Pro Gln Asp Leu Asn Lys Gly Ala Gly Gly Asp 
385                 390                 395                 400 
Asp Val Phe Leu Cys Tyr Lys Thr Glu Ala Tyr Asn Thr Asp Thr Ala 
                405                 410                 415     
Ile Asn Lys Val Thr Val Ile Gly Gly Asn Asn Ala Asp Ile Asn Ala 
            420                 425                 430         
Pro Tyr Gly Tyr Leu Lys Val Pro Gly Asp Leu Asn Arg Gly Ala Gly 
        435                 440                 445             
Gly Asn Phe Ile Tyr Ala Cys Thr Phe Val Gly Lys 
    450                 455                 460 

<210>  11
<211>  1446
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  11
atggaaaaca tagacttgcc acaaggactt gtaaactttt ccacgcaaca cctgcaactt       60
attcgtttta aagcaggttt gaatgaaacc gtactacctg gcgtcgaagc cattggactt      120
ggctataacc cattcatcag ttatgccagt gtcaacagcg gcgcggtgca attgttcgac      180
tgggccacgg ccaagaaacg cgaagtgcct ttcaaagccg gctacttcgt acccgagatc      240
gtcgacgtgc aacagaacga cagcgcaacc tacaccaacg tcagcggcaa cacgatcagc      300
gagtaccagc gcagtctggc taccagcgtc gccatcgaag gccgttacaa cttcttcagt      360
ggctcgctgt ccacggattt cgacagtaat tcactgcgca acgcggaaaa cgagttcact      420
cgcattcagc aatcgatcaa cctctggtcg ttgcgcttgc cttcggtgaa gtcattgcgc      480
gaactgatgc tgccacacat gcgccaacaa ctagatgaat tgaacgtcaa cgacccgaag      540
gccataagcc gctatttcga tagagttggc agccatttcc ttaccggcat cgtaatgggt      600
ggacgggcca tcctcgcctc ctcgaccaac aagctcaggg tcaagcgtga ctactcggtg      660
tcggtggtcg ccaaggcgag ctacgaaggg cttaccggcc agttgagcgc agaagcccgt      720
accaagtatg gcgagtctat gagcagcttc actcagtact ccagcaccca ccaggaagtg      780
cgcggcggcg acggtaccaa ggcacatggt gtgttcgaag gcaaagcagg tttccaggcc      840
tgggtagaca gcgtgggcac ctctccggac ttcgtcgatt tcgtccctac catccctatg      900
ctggaaatct ggtccctgtg caaaaccgac tctcaggccg aggccatgaa acgtcatttc      960
gataccgtct gggcgcgtga gcaatctgac aagtaccgta tcaaggctaa ctacatcgac     1020
caactggtgg tcatcaccgg cgatagctct accatcgaac caccggccgg ctacaccaag     1080
atcccgtacg acctgaatgc cggtgccaaa ggtgacttca tctacctgtg ctatcacgaa     1140
caagcctggt accctgacaa cactaaacct gctgtgacgg ctatcaagat catttacgac     1200
cgtgagcctg tcccaactgg ctatatcaag ctgcctcagg acctgaacaa gggcgcgggc     1260
ggtgctgata tctacctgtg ctacaagctg gagggttaca acaccgacac cgcaatcaac     1320
aagatcacgg tcatcagcgg caacaatccg gatatcaacg ctccttatgg ttatgagaag     1380
gtccctggtg acctgaacaa aggtgctaaa ggcaacttca tctatgcctg taccttcgta     1440
ggcaag                                                                1446

<210>  12
<211>  482
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  12
Met Glu Asn Ile Asp Leu Pro Gln Gly Leu Val Asn Phe Ser Thr Gln 
1               5                   10                  15      
His Leu Gln Leu Ile Arg Phe Lys Ala Gly Leu Asn Glu Thr Val Leu 
            20                  25                  30          
Pro Gly Val Glu Ala Ile Gly Leu Gly Tyr Asn Pro Phe Ile Ser Tyr 
        35                  40                  45              
Ala Ser Val Asn Ser Gly Ala Val Gln Leu Phe Asp Trp Ala Thr Ala 
    50                  55                  60                  
Lys Lys Arg Glu Val Pro Phe Lys Ala Gly Tyr Phe Val Pro Glu Ile 
65                  70                  75                  80  
Val Asp Val Gln Gln Asn Asp Ser Ala Thr Tyr Thr Asn Val Ser Gly 
                85                  90                  95      
Asn Thr Ile Ser Glu Tyr Gln Arg Ser Leu Ala Thr Ser Val Ala Ile 
            100                 105                 110         
Glu Gly Arg Tyr Asn Phe Phe Ser Gly Ser Leu Ser Thr Asp Phe Asp 
        115                 120                 125             
Ser Asn Ser Leu Arg Asn Ala Glu Asn Glu Phe Thr Arg Ile Gln Gln 
    130                 135                 140                 
Ser Ile Asn Leu Trp Ser Leu Arg Leu Pro Ser Val Lys Ser Leu Arg 
145                 150                 155                 160 
Glu Leu Met Leu Pro His Met Arg Gln Gln Leu Asp Glu Leu Asn Val 
                165                 170                 175     
Asn Asp Pro Lys Ala Ile Ser Arg Tyr Phe Asp Arg Val Gly Ser His 
            180                 185                 190         
Phe Leu Thr Gly Ile Val Met Gly Gly Arg Ala Ile Leu Ala Ser Ser 
        195                 200                 205             
Thr Asn Lys Leu Arg Val Lys Arg Asp Tyr Ser Val Ser Val Val Ala 
    210                 215                 220                 
Lys Ala Ser Tyr Glu Gly Leu Thr Gly Gln Leu Ser Ala Glu Ala Arg 
225                 230                 235                 240 
Thr Lys Tyr Gly Glu Ser Met Ser Ser Phe Thr Gln Tyr Ser Ser Thr 
                245                 250                 255     
His Gln Glu Val Arg Gly Gly Asp Gly Thr Lys Ala His Gly Val Phe 
            260                 265                 270         
Glu Gly Lys Ala Gly Phe Gln Ala Trp Val Asp Ser Val Gly Thr Ser 
        275                 280                 285             
Pro Asp Phe Val Asp Phe Val Pro Thr Ile Pro Met Leu Glu Ile Trp 
    290                 295                 300                 
Ser Leu Cys Lys Thr Asp Ser Gln Ala Glu Ala Met Lys Arg His Phe 
305                 310                 315                 320 
Asp Thr Val Trp Ala Arg Glu Gln Ser Asp Lys Tyr Arg Ile Lys Ala 
                325                 330                 335     
Asn Tyr Ile Asp Gln Leu Val Val Ile Thr Gly Asp Ser Ser Thr Ile 
            340                 345                 350         
Glu Pro Pro Ala Gly Tyr Thr Lys Ile Pro Tyr Asp Leu Asn Ala Gly 
        355                 360                 365             
Ala Lys Gly Asp Phe Ile Tyr Leu Cys Tyr His Glu Gln Ala Trp Tyr 
    370                 375                 380                 
Pro Asp Asn Thr Lys Pro Ala Val Thr Ala Ile Lys Ile Ile Tyr Asp 
385                 390                 395                 400 
Arg Glu Pro Val Pro Thr Gly Tyr Ile Lys Leu Pro Gln Asp Leu Asn 
                405                 410                 415     
Lys Gly Ala Gly Gly Ala Asp Ile Tyr Leu Cys Tyr Lys Leu Glu Gly 
            420                 425                 430         
Tyr Asn Thr Asp Thr Ala Ile Asn Lys Ile Thr Val Ile Ser Gly Asn 
        435                 440                 445             
Asn Pro Asp Ile Asn Ala Pro Tyr Gly Tyr Glu Lys Val Pro Gly Asp 
    450                 455                 460                 
Leu Asn Lys Gly Ala Lys Gly Asn Phe Ile Tyr Ala Cys Thr Phe Val 
465                 470                 475                 480 
Gly Lys 
        

<210>  13
<211>  1449
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  13
atggaaaaca tagacttgcc acaaggactt gtaaactttt ccacgcaaca cctgcaactt       60
attcgtttta aagcaggttt gaatgaaacc gtactacctg gcgtcgaagc cattggactt      120
ggctataacc cattcatcag ttatgccagt gtcaacagcg gcgcggtgca attgttcgac      180
tgggccacgg ccaagaaacg cgaagtgcct ttcaaagccg gctacttcgt acccgagatc      240
gtcgacgtgc aacagaacga cagcgcaacc tacaccaacg tcagcggcaa cacgatcagc      300
gagtaccagc gcagtctggc taccagcgtc gccatcgaag gccgttacaa cttcttcagt      360
ggctcgctgt ccacggattt cgacagtaat tcactgcgca acgcggaaaa cgagttcact      420
cgcattcagc aatcgatcaa cctctggtcg ttgcgcttgc cttcggtgaa gtcattgcgc      480
gaactgatgc tgccacacat gcgccaacaa ctagatgaat tgaacgtcaa cgacccgaag      540
gccataagcc gctatttcga tagagttggc agccatttcc ttaccggcat cgtaatgggt      600
ggacgggcca tcctcgcctc ctcgaccaac aagctcaggg tcaagcgtga ctactcggtg      660
tcggtggtcg ccaaggcgag ctacgaaggg cttaccggcc agttgagcgc agaagccaaa      720
gccaagtatg gcgagtcgat cagcagcttc actcagtact ccaataccca ccaggaagtg      780
cgcggcggcg acggtgccaa ggcacatggg gtgttcagcg gcaaaaaaga agatttccag      840
gcctgggtag acagtgtgag cgcctcgccg gacttcgtcg atttcgtccc taccatccct      900
atgctggaaa tctggtccct gtgcaaaacc gactctcagg ccgaggccat gaaacgtcat      960
ttcgataccg tctgggcgcg tgagcaatct gacaagtacc gtatcaaggc taactacatc     1020
gaccaactgg tggtcatcac cggcgatagc tctaccatcg aaccaccggc cggctacacc     1080
aagatcccgt acgacctgaa tgccggtgcc aaaggtgact tcatctacct gtgctatcac     1140
gaacaagcct ggtaccctga caacactaaa cctgctgtga cggctatcaa gatcatttac     1200
gaccgtgagc ctgtcccaac tggctatatc aagctgcctc aggacctgaa caagggcgcg     1260
ggcggtgctg atatctacct gtgctacaag ctggagggtt acaacaccga caccgcaatc     1320
aacaagatca cggtcatcag cggcaacaat ccggatatca acgctcctta tggttatgag     1380
aaggtccctg gtgacctgaa caaaggtgct aaaggcaact tcatctatgc ctgtaccttc     1440
gtaggcaag                                                             1449

<210>  14
<211>  483
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  14
Met Glu Asn Ile Asp Leu Pro Gln Gly Leu Val Asn Phe Ser Thr Gln 
1               5                   10                  15      
His Leu Gln Leu Ile Arg Phe Lys Ala Gly Leu Asn Glu Thr Val Leu 
            20                  25                  30          
Pro Gly Val Glu Ala Ile Gly Leu Gly Tyr Asn Pro Phe Ile Ser Tyr 
        35                  40                  45              
Ala Ser Val Asn Ser Gly Ala Val Gln Leu Phe Asp Trp Ala Thr Ala 
    50                  55                  60                  
Lys Lys Arg Glu Val Pro Phe Lys Ala Gly Tyr Phe Val Pro Glu Ile 
65                  70                  75                  80  
Val Asp Val Gln Gln Asn Asp Ser Ala Thr Tyr Thr Asn Val Ser Gly 
                85                  90                  95      
Asn Thr Ile Ser Glu Tyr Gln Arg Ser Leu Ala Thr Ser Val Ala Ile 
            100                 105                 110         
Glu Gly Arg Tyr Asn Phe Phe Ser Gly Ser Leu Ser Thr Asp Phe Asp 
        115                 120                 125             
Ser Asn Ser Leu Arg Asn Ala Glu Asn Glu Phe Thr Arg Ile Gln Gln 
    130                 135                 140                 
Ser Ile Asn Leu Trp Ser Leu Arg Leu Pro Ser Val Lys Ser Leu Arg 
145                 150                 155                 160 
Glu Leu Met Leu Pro His Met Arg Gln Gln Leu Asp Glu Leu Asn Val 
                165                 170                 175     
Asn Asp Pro Lys Ala Ile Ser Arg Tyr Phe Asp Arg Val Gly Ser His 
            180                 185                 190         
Phe Leu Thr Gly Ile Val Met Gly Gly Arg Ala Ile Leu Ala Ser Ser 
        195                 200                 205             
Thr Asn Lys Leu Arg Val Lys Arg Asp Tyr Ser Val Ser Val Val Ala 
    210                 215                 220                 
Lys Ala Ser Tyr Glu Gly Leu Thr Gly Gln Leu Ser Ala Glu Ala Lys 
225                 230                 235                 240 
Ala Lys Tyr Gly Glu Ser Ile Ser Ser Phe Thr Gln Tyr Ser Asn Thr 
                245                 250                 255     
His Gln Glu Val Arg Gly Gly Asp Gly Ala Lys Ala His Gly Val Phe 
            260                 265                 270         
Ser Gly Lys Lys Glu Asp Phe Gln Ala Trp Val Asp Ser Val Ser Ala 
        275                 280                 285             
Ser Pro Asp Phe Val Asp Phe Val Pro Thr Ile Pro Met Leu Glu Ile 
    290                 295                 300                 
Trp Ser Leu Cys Lys Thr Asp Ser Gln Ala Glu Ala Met Lys Arg His 
305                 310                 315                 320 
Phe Asp Thr Val Trp Ala Arg Glu Gln Ser Asp Lys Tyr Arg Ile Lys 
                325                 330                 335     
Ala Asn Tyr Ile Asp Gln Leu Val Val Ile Thr Gly Asp Ser Ser Thr 
            340                 345                 350         
Ile Glu Pro Pro Ala Gly Tyr Thr Lys Ile Pro Tyr Asp Leu Asn Ala 
        355                 360                 365             
Gly Ala Lys Gly Asp Phe Ile Tyr Leu Cys Tyr His Glu Gln Ala Trp 
    370                 375                 380                 
Tyr Pro Asp Asn Thr Lys Pro Ala Val Thr Ala Ile Lys Ile Ile Tyr 
385                 390                 395                 400 
Asp Arg Glu Pro Val Pro Thr Gly Tyr Ile Lys Leu Pro Gln Asp Leu 
                405                 410                 415     
Asn Lys Gly Ala Gly Gly Ala Asp Ile Tyr Leu Cys Tyr Lys Leu Glu 
            420                 425                 430         
Gly Tyr Asn Thr Asp Thr Ala Ile Asn Lys Ile Thr Val Ile Ser Gly 
        435                 440                 445             
Asn Asn Pro Asp Ile Asn Ala Pro Tyr Gly Tyr Glu Lys Val Pro Gly 
    450                 455                 460                 
Asp Leu Asn Lys Gly Ala Lys Gly Asn Phe Ile Tyr Ala Cys Thr Phe 
465                 470                 475                 480 
Val Gly Lys 
            

<210>  15
<211>  1449
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  15
atggaaaaca tagacttgcc acaaggactt gtaaactttt ccacgcaaca cctgcaactt       60
attcgtttta aagcaggttt gaatgaaacc gtactacctg gcgtcgaagc cattggactt      120
ggctataacc cattcatcag ttatgccagt gtcaacagcg gcgcggtgca attgttcgac      180
tgggccacgg ccaagaaacg cgaagtgcct ttcaaagccg gctacttcgt acccgagatc      240
gtcgacgtgc aacagaacga cagcgcaacc tacaccaacg tcagcggcaa cacgatcagc      300
gagtaccagc gcagtctggc taccagcgtc gccatcgaag gccgttacaa cttcttcagt      360
ggctcgctgt ccacggattt cgacagtaat tcactgcgca acgcggaaaa cgagttcact      420
cgcattcagc aatcgatcaa cctctggtcg ttgcgcttgc cttcggtgaa gtcattgcgc      480
gaactgatgc tgccacacat gcgccaacaa ctagatgaat tgaacgtcaa cgacccgaag      540
gccataagcc gctatttcga tagagttggc agccatttcc ttaccggcat cgtaatgggt      600
ggacgggcca tcctcgcctc ctcgaccaac aagctcaggg tcaagcgtga ctactcggtg      660
tcggtggtcg ccaaggcgag ctacgaaggg cttaccggcc agttgagcgc agaagccaaa      720
gccaagtatg gcgagtcgat cagcagcttc actcagtact ccaataccca ccaggaagtg      780
cgcggcggcg acggtgccaa ggcacatggg gtgttcagcg gcaaaaaaga agatttccag      840
gcctgggtag acagtgtgag cgcctcgccg gacttcgtcg atttcgtccc caccatcccc      900
atgcaggaaa tctggaccct gtgcagcagc gaggcgcagg ccgaggccat gcgcaagcat      960
tacgatgacg tctgggcgcc ggcgcaatcg gaaaagtacc gggtcaaggc taactacatc     1020
gaccaactgg tggtcatcac cggcgatagc tctaccatcg aaccaccggc cggctacacc     1080
aagatcccgt acgacctgaa tgccggtgcc aaaggtgact tcatctacct gtgctatcac     1140
gaacaagcct ggtaccctga caacactaaa cctgctgtga cggctatcaa gatcatttac     1200
gaccgtgagc ctgtcccaac tggctatatc aagctgcctc aggacctgaa caagggcgcg     1260
ggcggtgctg atatctacct gtgctacaag ctggagggtt acaacaccga caccgcaatc     1320
aacaagatca cggtcatcag cggcaacaat ccggatatca acgctcctta tggttatgag     1380
aaggtccctg gtgacctgaa caaaggtgct aaaggcaact tcatctatgc ctgtaccttc     1440
gtaggcaag                                                             1449

<210>  16
<211>  483
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  16
Met Glu Asn Ile Asp Leu Pro Gln Gly Leu Val Asn Phe Ser Thr Gln 
1               5                   10                  15      
His Leu Gln Leu Ile Arg Phe Lys Ala Gly Leu Asn Glu Thr Val Leu 
            20                  25                  30          
Pro Gly Val Glu Ala Ile Gly Leu Gly Tyr Asn Pro Phe Ile Ser Tyr 
        35                  40                  45              
Ala Ser Val Asn Ser Gly Ala Val Gln Leu Phe Asp Trp Ala Thr Ala 
    50                  55                  60                  
Lys Lys Arg Glu Val Pro Phe Lys Ala Gly Tyr Phe Val Pro Glu Ile 
65                  70                  75                  80  
Val Asp Val Gln Gln Asn Asp Ser Ala Thr Tyr Thr Asn Val Ser Gly 
                85                  90                  95      
Asn Thr Ile Ser Glu Tyr Gln Arg Ser Leu Ala Thr Ser Val Ala Ile 
            100                 105                 110         
Glu Gly Arg Tyr Asn Phe Phe Ser Gly Ser Leu Ser Thr Asp Phe Asp 
        115                 120                 125             
Ser Asn Ser Leu Arg Asn Ala Glu Asn Glu Phe Thr Arg Ile Gln Gln 
    130                 135                 140                 
Ser Ile Asn Leu Trp Ser Leu Arg Leu Pro Ser Val Lys Ser Leu Arg 
145                 150                 155                 160 
Glu Leu Met Leu Pro His Met Arg Gln Gln Leu Asp Glu Leu Asn Val 
                165                 170                 175     
Asn Asp Pro Lys Ala Ile Ser Arg Tyr Phe Asp Arg Val Gly Ser His 
            180                 185                 190         
Phe Leu Thr Gly Ile Val Met Gly Gly Arg Ala Ile Leu Ala Ser Ser 
        195                 200                 205             
Thr Asn Lys Leu Arg Val Lys Arg Asp Tyr Ser Val Ser Val Val Ala 
    210                 215                 220                 
Lys Ala Ser Tyr Glu Gly Leu Thr Gly Gln Leu Ser Ala Glu Ala Lys 
225                 230                 235                 240 
Ala Lys Tyr Gly Glu Ser Ile Ser Ser Phe Thr Gln Tyr Ser Asn Thr 
                245                 250                 255     
His Gln Glu Val Arg Gly Gly Asp Gly Ala Lys Ala His Gly Val Phe 
            260                 265                 270         
Ser Gly Lys Lys Glu Asp Phe Gln Ala Trp Val Asp Ser Val Ser Ala 
        275                 280                 285             
Ser Pro Asp Phe Val Asp Phe Val Pro Thr Ile Pro Met Gln Glu Ile 
    290                 295                 300                 
Trp Thr Leu Cys Ser Ser Glu Ala Gln Ala Glu Ala Met Arg Lys His 
305                 310                 315                 320 
Tyr Asp Asp Val Trp Ala Pro Ala Gln Ser Glu Lys Tyr Arg Val Lys 
                325                 330                 335     
Ala Asn Tyr Ile Asp Gln Leu Val Val Ile Thr Gly Asp Ser Ser Thr 
            340                 345                 350         
Ile Glu Pro Pro Ala Gly Tyr Thr Lys Ile Pro Tyr Asp Leu Asn Ala 
        355                 360                 365             
Gly Ala Lys Gly Asp Phe Ile Tyr Leu Cys Tyr His Glu Gln Ala Trp 
    370                 375                 380                 
Tyr Pro Asp Asn Thr Lys Pro Ala Val Thr Ala Ile Lys Ile Ile Tyr 
385                 390                 395                 400 
Asp Arg Glu Pro Val Pro Thr Gly Tyr Ile Lys Leu Pro Gln Asp Leu 
                405                 410                 415     
Asn Lys Gly Ala Gly Gly Ala Asp Ile Tyr Leu Cys Tyr Lys Leu Glu 
            420                 425                 430         
Gly Tyr Asn Thr Asp Thr Ala Ile Asn Lys Ile Thr Val Ile Ser Gly 
        435                 440                 445             
Asn Asn Pro Asp Ile Asn Ala Pro Tyr Gly Tyr Glu Lys Val Pro Gly 
    450                 455                 460                 
Asp Leu Asn Lys Gly Ala Lys Gly Asn Phe Ile Tyr Ala Cys Thr Phe 
465                 470                 475                 480 
Val Gly Lys 
            

<210>  17
<211>  1449
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  17
atggaaaaca tagacttgcc acaaggactt gtaaactttt ccacgcaaca cctgcaactt       60
attcgtttta aagcaggttt gaatgaaacc gtactacctg gcgtcgaagc cattggactt      120
ggctataacc cattcatcag ttatgccagt gtcaacagcg gcgcggtgca attgttcgac      180
tgggccacgg ccaagaaacg cgaagtgcct ttcaaagccg gctacttcgt acccgagatc      240
gtcgacgtgc aacagaacga cagcgcaacc tacaccaacg tcagcggcaa cacgatcagc      300
gagtaccagc gcagtctggc taccagcgtc gccatcgaag gccgttacaa cttcttcagt      360
ggctcgctgt ccacggattt cgacagtaat tcactgcgca acgcggaaaa cgagttcact      420
cgcattcagc aatcgatcaa cctctggtcg ttgcgcttgc cttcggtgaa gtcattgcgc      480
gaactgatgc tgccacacat gcgccaacaa ctagatgaat tgaacgtcaa cgacccgaag      540
gccataagcc gctatttcga tagagttggc agccatttcc ttaccggcat cgtaatgggt      600
ggacgggcca tcctcgcctc ctcgaccaac aagctcaggg tcaagcgtga ctactcggtg      660
tcggtggtcg ccaaggcgag ctacgaaggg cttaccggcc agttgagcgc agaagccaaa      720
gccaagtatg gcgagtcgat cagcagcttc actcagtact ccaataccca ccaggaagtg      780
cgcggcggcg acggtgccaa ggcacatggg gtgttcagcg gcaaaaaaga agatttccag      840
gcctgggtag acagtgtgag cgcctcgccg gacttcgtcg atttcgtccc caccatcccc      900
atgcaggaaa tctggaccct gtgcagcagc gaggcgcagg ccgaggccat gcgcaagcat      960
tacgatgacg tctgggcgcc ggcgcaatcg gaaaagtacc gggtcaaggc taactacatc     1020
gaccaactgg tggtcatcac cggcggtagt tcaaccatcg aaccaccggt cggctacagc     1080
aagatcgagt acgacctcaa tgccggtgcc ggcggtgact tcatctactt gtgctatcac     1140
gaacaagcct ggtaccctga caacactaaa cctgctgtga cggctatcaa gatcatttac     1200
gaccgtgagc ctgtcccaac tggctatatc aagctgcctc aggacctgaa caagggcgcg     1260
ggcggtgctg atatctacct gtgctacaag ctggagggtt acaacaccga caccgcaatc     1320
aacaagatca cggtcatcag cggcaacaat ccggatatca acgctcctta tggttatgag     1380
aaggtccctg gtgacctgaa caaaggtgct aaaggcaact tcatctatgc ctgtaccttc     1440
gtaggcaag                                                             1449

<210>  18
<211>  483
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  18
Met Glu Asn Ile Asp Leu Pro Gln Gly Leu Val Asn Phe Ser Thr Gln 
1               5                   10                  15      
His Leu Gln Leu Ile Arg Phe Lys Ala Gly Leu Asn Glu Thr Val Leu 
            20                  25                  30          
Pro Gly Val Glu Ala Ile Gly Leu Gly Tyr Asn Pro Phe Ile Ser Tyr 
        35                  40                  45              
Ala Ser Val Asn Ser Gly Ala Val Gln Leu Phe Asp Trp Ala Thr Ala 
    50                  55                  60                  
Lys Lys Arg Glu Val Pro Phe Lys Ala Gly Tyr Phe Val Pro Glu Ile 
65                  70                  75                  80  
Val Asp Val Gln Gln Asn Asp Ser Ala Thr Tyr Thr Asn Val Ser Gly 
                85                  90                  95      
Asn Thr Ile Ser Glu Tyr Gln Arg Ser Leu Ala Thr Ser Val Ala Ile 
            100                 105                 110         
Glu Gly Arg Tyr Asn Phe Phe Ser Gly Ser Leu Ser Thr Asp Phe Asp 
        115                 120                 125             
Ser Asn Ser Leu Arg Asn Ala Glu Asn Glu Phe Thr Arg Ile Gln Gln 
    130                 135                 140                 
Ser Ile Asn Leu Trp Ser Leu Arg Leu Pro Ser Val Lys Ser Leu Arg 
145                 150                 155                 160 
Glu Leu Met Leu Pro His Met Arg Gln Gln Leu Asp Glu Leu Asn Val 
                165                 170                 175     
Asn Asp Pro Lys Ala Ile Ser Arg Tyr Phe Asp Arg Val Gly Ser His 
            180                 185                 190         
Phe Leu Thr Gly Ile Val Met Gly Gly Arg Ala Ile Leu Ala Ser Ser 
        195                 200                 205             
Thr Asn Lys Leu Arg Val Lys Arg Asp Tyr Ser Val Ser Val Val Ala 
    210                 215                 220                 
Lys Ala Ser Tyr Glu Gly Leu Thr Gly Gln Leu Ser Ala Glu Ala Lys 
225                 230                 235                 240 
Ala Lys Tyr Gly Glu Ser Ile Ser Ser Phe Thr Gln Tyr Ser Asn Thr 
                245                 250                 255     
His Gln Glu Val Arg Gly Gly Asp Gly Ala Lys Ala His Gly Val Phe 
            260                 265                 270         
Ser Gly Lys Lys Glu Asp Phe Gln Ala Trp Val Asp Ser Val Ser Ala 
        275                 280                 285             
Ser Pro Asp Phe Val Asp Phe Val Pro Thr Ile Pro Met Gln Glu Ile 
    290                 295                 300                 
Trp Thr Leu Cys Ser Ser Glu Ala Gln Ala Glu Ala Met Arg Lys His 
305                 310                 315                 320 
Tyr Asp Asp Val Trp Ala Pro Ala Gln Ser Glu Lys Tyr Arg Val Lys 
                325                 330                 335     
Ala Asn Tyr Ile Asp Gln Leu Val Val Ile Thr Gly Gly Ser Ser Thr 
            340                 345                 350         
Ile Glu Pro Pro Val Gly Tyr Ser Lys Ile Glu Tyr Asp Leu Asn Ala 
        355                 360                 365             
Gly Ala Gly Gly Asp Phe Ile Tyr Leu Cys Tyr His Glu Gln Ala Trp 
    370                 375                 380                 
Tyr Pro Asp Asn Thr Lys Pro Ala Val Thr Ala Ile Lys Ile Ile Tyr 
385                 390                 395                 400 
Asp Arg Glu Pro Val Pro Thr Gly Tyr Ile Lys Leu Pro Gln Asp Leu 
                405                 410                 415     
Asn Lys Gly Ala Gly Gly Ala Asp Ile Tyr Leu Cys Tyr Lys Leu Glu 
            420                 425                 430         
Gly Tyr Asn Thr Asp Thr Ala Ile Asn Lys Ile Thr Val Ile Ser Gly 
        435                 440                 445             
Asn Asn Pro Asp Ile Asn Ala Pro Tyr Gly Tyr Glu Lys Val Pro Gly 
    450                 455                 460                 
Asp Leu Asn Lys Gly Ala Lys Gly Asn Phe Ile Tyr Ala Cys Thr Phe 
465                 470                 475                 480 
Val Gly Lys 
            

<210>  19
<211>  1449
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  19
atggaaaaca tagacttgcc acaaggactt gtaaactttt ccacgcaaca cctgcaactt       60
attcgtttta aagcaggttt gaatgaaacc gtactacctg gcgtcgaagc cattggactt      120
ggctataacc cattcatcag ttatgccagt gtcaacagcg gcgcggtgca attgttcgac      180
tgggccacgg ccaagaaacg cgaagtgcct ttcaaagccg gctacttcgt acccgagatc      240
gtcgacgtgc aacagaacga cagcgcaacc tacaccaacg tcagcggcaa cacgatcagc      300
gagtaccagc gcagtctggc taccagcgtc gccatcgaag gccgttacaa cttcttcagt      360
ggctcgctgt ccacggattt cgacagtaat tcactgcgca acgcggaaaa cgagttcact      420
cgcattcagc aatcgatcaa cctctggtcg ttgcgcttgc cttcggtgaa gtcattgcgc      480
gaactgatgc tgccacacat gcgccaacaa ctagatgaat tgaacgtcaa cgacccgaag      540
gccataagcc gctatttcga tagagttggc agccatttcc ttaccggcat cgtaatgggt      600
ggacgggcca tcctcgcctc ctcgaccaac aagctcaggg tcaagcgtga ctactcggtg      660
tcggtggtcg ccaaggcgag ctacgaaggg cttaccggcc agttgagcgc agaagccaaa      720
gccaagtatg gcgagtcgat cagcagcttc actcagtact ccaataccca ccaggaagtg      780
cgcggcggcg acggtgccaa ggcacatggg gtgttcagcg gcaaaaaaga agatttccag      840
gcctgggtag acagtgtgag cgcctcgccg gacttcgtcg atttcgtccc caccatcccc      900
atgcaggaaa tctggaccct gtgcagcagc gaggcgcagg ccgaggccat gcgcaagcat      960
tacgatgacg tctgggcgcc ggcgcaatcg gaaaagtacc gggtcaaggc taactacatc     1020
gaccaactgg tggtcatcac cggcggtagt tcaaccatcg aaccaccggt cggctacagc     1080
aagatcgagt acgacctcaa tgccggtgcc ggcggtgact tcatctactt gtgctatcac     1140
gaacaaacct ggcaggccga caggcctaaa gatgctgtga cggatatcag gatcattttc     1200
aacaaggagc ctaccccacc tggctatacc aagctgcccc aggacctgaa caagggcgcg     1260
ggcggtgctg atatctacct gtgctacaag ctggagggtt acaacaccga caccgcaatc     1320
aacaagatca cggtcatcag cggcaacaat ccggatatca acgctcctta tggttatgag     1380
aaggtccctg gtgacctgaa caaaggtgct aaaggcaact tcatctatgc ctgtaccttc     1440
gtaggcaag                                                             1449

<210>  20
<211>  483
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  20
Met Glu Asn Ile Asp Leu Pro Gln Gly Leu Val Asn Phe Ser Thr Gln 
1               5                   10                  15      
His Leu Gln Leu Ile Arg Phe Lys Ala Gly Leu Asn Glu Thr Val Leu 
            20                  25                  30          
Pro Gly Val Glu Ala Ile Gly Leu Gly Tyr Asn Pro Phe Ile Ser Tyr 
        35                  40                  45              
Ala Ser Val Asn Ser Gly Ala Val Gln Leu Phe Asp Trp Ala Thr Ala 
    50                  55                  60                  
Lys Lys Arg Glu Val Pro Phe Lys Ala Gly Tyr Phe Val Pro Glu Ile 
65                  70                  75                  80  
Val Asp Val Gln Gln Asn Asp Ser Ala Thr Tyr Thr Asn Val Ser Gly 
                85                  90                  95      
Asn Thr Ile Ser Glu Tyr Gln Arg Ser Leu Ala Thr Ser Val Ala Ile 
            100                 105                 110         
Glu Gly Arg Tyr Asn Phe Phe Ser Gly Ser Leu Ser Thr Asp Phe Asp 
        115                 120                 125             
Ser Asn Ser Leu Arg Asn Ala Glu Asn Glu Phe Thr Arg Ile Gln Gln 
    130                 135                 140                 
Ser Ile Asn Leu Trp Ser Leu Arg Leu Pro Ser Val Lys Ser Leu Arg 
145                 150                 155                 160 
Glu Leu Met Leu Pro His Met Arg Gln Gln Leu Asp Glu Leu Asn Val 
                165                 170                 175     
Asn Asp Pro Lys Ala Ile Ser Arg Tyr Phe Asp Arg Val Gly Ser His 
            180                 185                 190         
Phe Leu Thr Gly Ile Val Met Gly Gly Arg Ala Ile Leu Ala Ser Ser 
        195                 200                 205             
Thr Asn Lys Leu Arg Val Lys Arg Asp Tyr Ser Val Ser Val Val Ala 
    210                 215                 220                 
Lys Ala Ser Tyr Glu Gly Leu Thr Gly Gln Leu Ser Ala Glu Ala Lys 
225                 230                 235                 240 
Ala Lys Tyr Gly Glu Ser Ile Ser Ser Phe Thr Gln Tyr Ser Asn Thr 
                245                 250                 255     
His Gln Glu Val Arg Gly Gly Asp Gly Ala Lys Ala His Gly Val Phe 
            260                 265                 270         
Ser Gly Lys Lys Glu Asp Phe Gln Ala Trp Val Asp Ser Val Ser Ala 
        275                 280                 285             
Ser Pro Asp Phe Val Asp Phe Val Pro Thr Ile Pro Met Gln Glu Ile 
    290                 295                 300                 
Trp Thr Leu Cys Ser Ser Glu Ala Gln Ala Glu Ala Met Arg Lys His 
305                 310                 315                 320 
Tyr Asp Asp Val Trp Ala Pro Ala Gln Ser Glu Lys Tyr Arg Val Lys 
                325                 330                 335     
Ala Asn Tyr Ile Asp Gln Leu Val Val Ile Thr Gly Gly Ser Ser Thr 
            340                 345                 350         
Ile Glu Pro Pro Val Gly Tyr Ser Lys Ile Glu Tyr Asp Leu Asn Ala 
        355                 360                 365             
Gly Ala Gly Gly Asp Phe Ile Tyr Leu Cys Tyr His Glu Gln Thr Trp 
    370                 375                 380                 
Gln Ala Asp Arg Pro Lys Asp Ala Val Thr Asp Ile Arg Ile Ile Phe 
385                 390                 395                 400 
Asn Lys Glu Pro Thr Pro Pro Gly Tyr Thr Lys Leu Pro Gln Asp Leu 
                405                 410                 415     
Asn Lys Gly Ala Gly Gly Ala Asp Ile Tyr Leu Cys Tyr Lys Leu Glu 
            420                 425                 430         
Gly Tyr Asn Thr Asp Thr Ala Ile Asn Lys Ile Thr Val Ile Ser Gly 
        435                 440                 445             
Asn Asn Pro Asp Ile Asn Ala Pro Tyr Gly Tyr Glu Lys Val Pro Gly 
    450                 455                 460                 
Asp Leu Asn Lys Gly Ala Lys Gly Asn Phe Ile Tyr Ala Cys Thr Phe 
465                 470                 475                 480 
Val Gly Lys 
            

<210>  21
<211>  1449
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  21
atggaaaaca tagacttgcc acaaggactt gtaaactttt ccacgcaaca cctgcaactt       60
attcgtttta aagcaggttt gaatgaaacc gtactacctg gcgtcgaagc cattggactt      120
ggctataacc cattcatcag ttatgccagt gtcaacagcg gcgcggtgca attgttcgac      180
tgggccacgg ccaagaaacg cgaagtgcct ttcaaagccg gctacttcgt acccgagatc      240
gtcgacgtgc aacagaacga cagcgcaacc tacaccaacg tcagcggcaa cacgatcagc      300
gagtaccagc gcagtctggc taccagcgtc gccatcgaag gccgttacaa cttcttcagt      360
ggctcgctgt ccacggattt cgacagtaat tcactgcgca acgcggaaaa cgagttcact      420
cgcattcagc aatcgatcaa cctctggtcg ttgcgcttgc cttcggtgaa gtcattgcgc      480
gaactgatgc tgccacacat gcgccaacaa ctagatgaat tgaacgtcaa cgacccgaag      540
gccataagcc gctatttcga tagagttggc agccatttcc ttaccggcat cgtaatgggt      600
ggacgggcca tcctcgcctc ctcgaccaac aagctcaggg tcaagcgtga ctactcggtg      660
tcggtggtcg ccaaggcgag ctacgaaggg cttaccggcc agttgagcgc agaagccaaa      720
gccaagtatg gcgagtcgat cagcagcttc actcagtact ccaataccca ccaggaagtg      780
cgcggcggcg acggtgccaa ggcacatggg gtgttcagcg gcaaaaaaga agatttccag      840
gcctgggtag acagtgtgag cgcctcgccg gacttcgtcg atttcgtccc caccatcccc      900
atgcaggaaa tctggaccct gtgcagcagc gaggcgcagg ccgaggccat gcgcaagcat      960
tacgatgacg tctgggcgcc ggcgcaatcg gaaaagtacc gggtcaaggc taactacatc     1020
gaccaactgg tggtcatcac cggcggtagt tcaaccatcg aaccaccggt cggctacagc     1080
aagatcgagt acgacctcaa tgccggtgcc ggcggtgact tcatctactt gtgctatcac     1140
gaacaaacct ggcaggccga caggcctaaa gatgctgtga cggatatcag gatcattttc     1200
aacaaggagc ctaccccacc tggctatacc aagctgcccc aggacctgaa caagggcgcg     1260
ggcggtgatg atgtattcct ctgctacaag accgaggctt acaacaccga caccgcaatc     1320
aacaagatca cggtcatcag cggcaacaat ccggatatca acgctcctta tggttatgag     1380
aaggtccctg gtgacctgaa caaaggtgct aaaggcaact tcatctatgc ctgtaccttc     1440
gtaggcaag                                                             1449

<210>  22
<211>  483
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  22
Met Glu Asn Ile Asp Leu Pro Gln Gly Leu Val Asn Phe Ser Thr Gln 
1               5                   10                  15      
His Leu Gln Leu Ile Arg Phe Lys Ala Gly Leu Asn Glu Thr Val Leu 
            20                  25                  30          
Pro Gly Val Glu Ala Ile Gly Leu Gly Tyr Asn Pro Phe Ile Ser Tyr 
        35                  40                  45              
Ala Ser Val Asn Ser Gly Ala Val Gln Leu Phe Asp Trp Ala Thr Ala 
    50                  55                  60                  
Lys Lys Arg Glu Val Pro Phe Lys Ala Gly Tyr Phe Val Pro Glu Ile 
65                  70                  75                  80  
Val Asp Val Gln Gln Asn Asp Ser Ala Thr Tyr Thr Asn Val Ser Gly 
                85                  90                  95      
Asn Thr Ile Ser Glu Tyr Gln Arg Ser Leu Ala Thr Ser Val Ala Ile 
            100                 105                 110         
Glu Gly Arg Tyr Asn Phe Phe Ser Gly Ser Leu Ser Thr Asp Phe Asp 
        115                 120                 125             
Ser Asn Ser Leu Arg Asn Ala Glu Asn Glu Phe Thr Arg Ile Gln Gln 
    130                 135                 140                 
Ser Ile Asn Leu Trp Ser Leu Arg Leu Pro Ser Val Lys Ser Leu Arg 
145                 150                 155                 160 
Glu Leu Met Leu Pro His Met Arg Gln Gln Leu Asp Glu Leu Asn Val 
                165                 170                 175     
Asn Asp Pro Lys Ala Ile Ser Arg Tyr Phe Asp Arg Val Gly Ser His 
            180                 185                 190         
Phe Leu Thr Gly Ile Val Met Gly Gly Arg Ala Ile Leu Ala Ser Ser 
        195                 200                 205             
Thr Asn Lys Leu Arg Val Lys Arg Asp Tyr Ser Val Ser Val Val Ala 
    210                 215                 220                 
Lys Ala Ser Tyr Glu Gly Leu Thr Gly Gln Leu Ser Ala Glu Ala Lys 
225                 230                 235                 240 
Ala Lys Tyr Gly Glu Ser Ile Ser Ser Phe Thr Gln Tyr Ser Asn Thr 
                245                 250                 255     
His Gln Glu Val Arg Gly Gly Asp Gly Ala Lys Ala His Gly Val Phe 
            260                 265                 270         
Ser Gly Lys Lys Glu Asp Phe Gln Ala Trp Val Asp Ser Val Ser Ala 
        275                 280                 285             
Ser Pro Asp Phe Val Asp Phe Val Pro Thr Ile Pro Met Gln Glu Ile 
    290                 295                 300                 
Trp Thr Leu Cys Ser Ser Glu Ala Gln Ala Glu Ala Met Arg Lys His 
305                 310                 315                 320 
Tyr Asp Asp Val Trp Ala Pro Ala Gln Ser Glu Lys Tyr Arg Val Lys 
                325                 330                 335     
Ala Asn Tyr Ile Asp Gln Leu Val Val Ile Thr Gly Gly Ser Ser Thr 
            340                 345                 350         
Ile Glu Pro Pro Val Gly Tyr Ser Lys Ile Glu Tyr Asp Leu Asn Ala 
        355                 360                 365             
Gly Ala Gly Gly Asp Phe Ile Tyr Leu Cys Tyr His Glu Gln Thr Trp 
    370                 375                 380                 
Gln Ala Asp Arg Pro Lys Asp Ala Val Thr Asp Ile Arg Ile Ile Phe 
385                 390                 395                 400 
Asn Lys Glu Pro Thr Pro Pro Gly Tyr Thr Lys Leu Pro Gln Asp Leu 
                405                 410                 415     
Asn Lys Gly Ala Gly Gly Asp Asp Val Phe Leu Cys Tyr Lys Thr Glu 
            420                 425                 430         
Ala Tyr Asn Thr Asp Thr Ala Ile Asn Lys Ile Thr Val Ile Ser Gly 
        435                 440                 445             
Asn Asn Pro Asp Ile Asn Ala Pro Tyr Gly Tyr Glu Lys Val Pro Gly 
    450                 455                 460                 
Asp Leu Asn Lys Gly Ala Lys Gly Asn Phe Ile Tyr Ala Cys Thr Phe 
465                 470                 475                 480 
Val Gly Lys 
            

<210>  23
<211>  1446
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  23
atggaaaaca tagacttgcc acaaggactt gtaaactttt ccacgcaaca cctgcaactt       60
attcgtttta aagcaggttt gaatgaaacc gtactacctg gcgtcgaagc cattggactt      120
ggctataacc cattcatcag ttatgccagt gtcaacagcg gcgcggtgca attgttcgac      180
tgggccacgg ccaagaaacg cgaagtgcct ttcaaagccg gctacttcgt acccgagatc      240
gtcgacgtgc aacagaacga cagcgcaacc tacaccaacg tcagcggcaa cacgatcagc      300
gagtaccagc gcagtctggc taccagcgtc gccatcgaag gccgttacaa cttcttcagt      360
ggctcgctgt ccacggattt cgacagtaat tcactgcgca acgcggaaaa cgagttcact      420
cgcattcagc aatctatcaa cctgtggtct ctgcgcctgc cttctgtgaa gtctctgcgc      480
gacctgatgc tgccacacat gcgcgaacaa ctggatgaac tggacgtcaa aaacccgagc      540
gccatcagcc gctttttcga tcgtgttggc agccatttcc tgaccggcat cgtaatgggt      600
ggtcgtgcca tcctggccgc ctctaccaac aagctgaagg tcaagcgtga ctactctgtg      660
tctgtgatcg ccaaggcgag ctacgaaggt ctgaccggcc agctgagcgc agaagcccgt      720
accaagtatg gcgagtctat gagcagcttc actcagtact ccagcaccca ccaggaagtg      780
cgcggcggcg acggtaccaa ggcacatggt gtgttcgaag gcaaagcagg tttccaggcc      840
tgggtagaca gcgtgggcac ctctccggac ttcgtcgatt tcgtccctac catccctatg      900
ctggaaatct ggtccctgtg caaaaccgac tctcaggccg aggccatgaa acgtcatttc      960
gataccgtct gggcgcgtga gcaatctgac aagtaccgta tcaaggctaa ctacatcgac     1020
caactggtgg tcatcaccgg cgatagctct accatcgaac caccggccgg ctacaccaag     1080
atcccgtacg acctgaatgc cggtgccaaa ggtgacttca tctacctgtg ctatcacgaa     1140
caagcctggt accctgacaa cactaaacct gctgtgacgg ctatcaagat catttacgac     1200
cgtgagcctg tcccaactgg ctatatcaag ctgcctcagg acctgaacaa gggcgcgggc     1260
ggtgctgata tctacctgtg ctacaagctg gagggttaca acaccgacac cgcaatcaac     1320
aagatcacgg tcatcagcgg caacaatccg gatatcaacg ctccttatgg ttatgagaag     1380
gtccctggtg acctgaacaa aggtgctaaa ggcaacttca tctatgcctg taccttcgta     1440
ggcaag                                                                1446

<210>  24
<211>  482
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  24
Met Glu Asn Ile Asp Leu Pro Gln Gly Leu Val Asn Phe Ser Thr Gln 
1               5                   10                  15      
His Leu Gln Leu Ile Arg Phe Lys Ala Gly Leu Asn Glu Thr Val Leu 
            20                  25                  30          
Pro Gly Val Glu Ala Ile Gly Leu Gly Tyr Asn Pro Phe Ile Ser Tyr 
        35                  40                  45              
Ala Ser Val Asn Ser Gly Ala Val Gln Leu Phe Asp Trp Ala Thr Ala 
    50                  55                  60                  
Lys Lys Arg Glu Val Pro Phe Lys Ala Gly Tyr Phe Val Pro Glu Ile 
65                  70                  75                  80  
Val Asp Val Gln Gln Asn Asp Ser Ala Thr Tyr Thr Asn Val Ser Gly 
                85                  90                  95      
Asn Thr Ile Ser Glu Tyr Gln Arg Ser Leu Ala Thr Ser Val Ala Ile 
            100                 105                 110         
Glu Gly Arg Tyr Asn Phe Phe Ser Gly Ser Leu Ser Thr Asp Phe Asp 
        115                 120                 125             
Ser Asn Ser Leu Arg Asn Ala Glu Asn Glu Phe Thr Arg Ile Gln Gln 
    130                 135                 140                 
Ser Ile Asn Leu Trp Ser Leu Arg Leu Pro Ser Val Lys Ser Leu Arg 
145                 150                 155                 160 
Asp Leu Met Leu Pro His Met Arg Glu Gln Leu Asp Glu Leu Asp Val 
                165                 170                 175     
Lys Asn Pro Ser Ala Ile Ser Arg Phe Phe Asp Arg Val Gly Ser His 
            180                 185                 190         
Phe Leu Thr Gly Ile Val Met Gly Gly Arg Ala Ile Leu Ala Ala Ser 
        195                 200                 205             
Thr Asn Lys Leu Lys Val Lys Arg Asp Tyr Ser Val Ser Val Ile Ala 
    210                 215                 220                 
Lys Ala Ser Tyr Glu Gly Leu Thr Gly Gln Leu Ser Ala Glu Ala Arg 
225                 230                 235                 240 
Thr Lys Tyr Gly Glu Ser Met Ser Ser Phe Thr Gln Tyr Ser Ser Thr 
                245                 250                 255     
His Gln Glu Val Arg Gly Gly Asp Gly Thr Lys Ala His Gly Val Phe 
            260                 265                 270         
Glu Gly Lys Ala Gly Phe Gln Ala Trp Val Asp Ser Val Gly Thr Ser 
        275                 280                 285             
Pro Asp Phe Val Asp Phe Val Pro Thr Ile Pro Met Leu Glu Ile Trp 
    290                 295                 300                 
Ser Leu Cys Lys Thr Asp Ser Gln Ala Glu Ala Met Lys Arg His Phe 
305                 310                 315                 320 
Asp Thr Val Trp Ala Arg Glu Gln Ser Asp Lys Tyr Arg Ile Lys Ala 
                325                 330                 335     
Asn Tyr Ile Asp Gln Leu Val Val Ile Thr Gly Asp Ser Ser Thr Ile 
            340                 345                 350         
Glu Pro Pro Ala Gly Tyr Thr Lys Ile Pro Tyr Asp Leu Asn Ala Gly 
        355                 360                 365             
Ala Lys Gly Asp Phe Ile Tyr Leu Cys Tyr His Glu Gln Ala Trp Tyr 
    370                 375                 380                 
Pro Asp Asn Thr Lys Pro Ala Val Thr Ala Ile Lys Ile Ile Tyr Asp 
385                 390                 395                 400 
Arg Glu Pro Val Pro Thr Gly Tyr Ile Lys Leu Pro Gln Asp Leu Asn 
                405                 410                 415     
Lys Gly Ala Gly Gly Ala Asp Ile Tyr Leu Cys Tyr Lys Leu Glu Gly 
            420                 425                 430         
Tyr Asn Thr Asp Thr Ala Ile Asn Lys Ile Thr Val Ile Ser Gly Asn 
        435                 440                 445             
Asn Pro Asp Ile Asn Ala Pro Tyr Gly Tyr Glu Lys Val Pro Gly Asp 
    450                 455                 460                 
Leu Asn Lys Gly Ala Lys Gly Asn Phe Ile Tyr Ala Cys Thr Phe Val 
465                 470                 475                 480 
Gly Lys 
        

<210>  25
<211>  1452
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  25
atggaacacg tcgacctgcc gacgggactc gtcaaatttt ccagcaatca ccatctgcaa       60
ttgctgcgcg acaccgccga cctcagtgaa tcagtgcttc cgggcgtaga ggccattggc      120
ttgggataca acccattcct cggctacgcc ggtgtgggaa gcggcaccgt ccagcttttc      180
gactggaaca acgcaaaaaa gaaaaaagtg tcattcaaac ccgagttcgt cgtgccggag      240
atcgtcgacg tccagcagaa tgacagcgcc agctacacca acatcagtgg caacaccgtc      300
accgagtatc aacgcagcct ggccgtcagc gtggccatcg aaggcaaata caacttcttc      360
agtggttcgc tttcaaccga ctacgacgaa aactcgctgc gtaatgccga gaacgagttc      420
acccgtatcc agcaatcgat caacctctgg tcgctgcgcc tgccttcggt caaatcactg      480
cgcgacctga tgctgccgca catgcgtgag caactggatg agctggacgt gaaaaacccg      540
agtgccatca gccggttctt cgaccgggtg ggcagccact tcctcaccgg catcgtgatg      600
ggcggccgag ccatactcgc cgcctcgacc aacaaactga aggtcaagcg cgactactcc      660
gtgtcggtca tcgccaaggc gagctacgaa gggcttaccg gccagttgag cgcagaagcc      720
aaagccaagt atggcgagtc gatcagcagc ttcactcagt actccaatac ccaccaggaa      780
gtgcgcggcg gcgacggtgc caaggcacat ggggtgttca gcggcaaaaa agaagatttc      840
caggcctggg tagacagtgt gagcgcctcg ccggacttcg tcgatttcgt ccccaccatc      900
cccatgcagg aaatctggac cctgtgcagc agcgaggcgc aggccgaggc catgcgcaag      960
cattacgatg acgtctgggc gccggcgcaa tcggaaaagt accgggtcaa ggctaactac     1020
atcgaccaac tggtggtcat caccggcggt agttcaacca tcgaaccacc ggtcggctac     1080
agcaagatcg agtacgacct caatgccggt gccggcggtg acttcatcta cttgtgctat     1140
cacgaacaaa cctggcaggc cgacaggcct aaagatgctg tgacggatat caggatcatt     1200
ttcaacaagg agcctacccc acctggctat accaagctgc cccaggacct gaacaagggc     1260
gcgggcggtg atgatgtatt cctctgctac aagaccgagg cttacaacac cgacaccgca     1320
atcaacaagg tcacggtcat cggcggcaac aatgcggata tcaacgctcc ctatggttat     1380
ctgaaggtcc ccgatgacct caacagaggt gctggcggca acttcatcta tgcctgtacc     1440
ttcgtaggca ag                                                         1452

<210>  26
<211>  1449
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  26
atggaacacg tcgacctgcc gacgggactc gtcaaatttt ccagcaatca ccatctgcaa       60
ttgctgcgcg acaccgccga cctcagtgaa tcagtgcttc cgggcgtaga ggccattggc      120
ttgggataca acccattcct cggctacgcc ggtgtgggaa gcggcaccgt ccagcttttc      180
gactggaaca acgcaaaaaa gaaaaaagtg tcattcaaac ccgagttcgt cgtgccggag      240
atcgtcgacg tccagcagaa tgacagcgcc agctacacca acatcagtgg caacaccgtc      300
accgagtatc aacgcagcct ggccgtcagc gtggccatcg aaggcaaata caacttcttc      360
agtggttcgc tttcaaccga ctacgacgaa aactcgctgc gtaatgccga gaacgagttc      420
acccgtatcc agcaatcgat caacctctgg tcgctgcgcc tgccttcggt caaatcactg      480
cgcgacctga tgctgccgca catgcgtgag caactggatg agctggacgt gaaaaacccg      540
agtgccatca gccggttctt cgaccgggtg ggcagccact tcctcaccgg catcgtgatg      600
ggcggccgag ccatactcgc cgcctcgacc aacaaactga aggtcaagct cgactactcc      660
gtgtcggtca tcgccaaggc gagctacgaa ggcttgaccg gccagctgag cgccgaggcc      720
aggaccaagt acggcgaatc catgagcagt ttcacccatt actccagcac ccaccaggaa      780
gtccgtggcg gcgatggcac caaggcccat ggtgtgttcg agggcaaggc cgggttccag      840
gcctgggtcg acagcgtggg gacctcgccc gatttcgtcg acttcgtgcc caccatcccg      900
atgctggaga tctggagcct gtgcaagacc gattcacagg ctgaagccat gaagcgccat      960
ttcgacacgg tctgggcccg cgaacaatcg gacaagtacc ggataaaggc gaactacatc     1020
gatcagctgg tggtaatcac cggtgacagt tcgaccatcg aacctccggc tggctatacc     1080
aagattccct acgacctcaa tgccggggcc aagggcgact tcatctattt gtgctaccac     1140
gaacaaacct ggcaggccga caggcctaaa gatgctgtga cggatatcag gatcattttc     1200
aacaaggagc ctaccccacc tggctatacc aagctgcccc aggacctgaa caagggcgcg     1260
ggcggtgatg atgtattcct ctgctacaag accgaggctt acaacaccga caccgcaatc     1320
aacaaggtca cggtcatcgg cggcaacaat gcggatatca acgctcccta tggttatctg     1380
aaggtccccg gtgacctcaa cagaggtgct ggcggcaact tcatctatgc ctgtaccttc     1440
gtaggcaag                                                             1449

<210>  27
<211>  1452
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  27
atggaacacg tcgacctgcc gacgggactc gtcaaatttt ccagcaatca ccatctgcaa       60
ttgctgcgcg acaccgccga cctcagtgaa tcagtgcttc cgggcgtaga ggccattggc      120
ttgggataca acccattcct cggctacgcc ggtgtgggaa gcggcaccgt ccagcttttc      180
gactggaaca acgcaaaaaa gaaaaaagtg tcattcaaac ccgagttcgt cgtgccggag      240
atcgtcgacg tccagcagaa tgacagcgcc agctacacca acatcagtgg caacaccttc      300
accgagtatc aacgcagcct ggccgtcagc gtggccatcg aaggcaaata caacttcttc      360
agtggttcgc tttcaaccga ctacgacgaa aactcgctgc gtaatgccga gaacgagttc      420
acccgtatcc agcaatcgat caacctctgg tcgctgcgcc tgccttcggt caaatcactg      480
cgcgacctga tgctgccgca catgcgtgag caactggatg agctggacgt gaaaaacccg      540
agtgccatca gccggttctt cgaccgggtg ggcagccact tcctcaccgg catcgtgatg      600
ggcggccgag ccatactcgc cgcctcgacc aacaaactga aggtcaagcg cgactactcc      660
gtgtcggtca tcgccaaggc gagctacgaa ggcttgaccg gccagctgag cgccgaggcc      720
aggaacaagt acggcgaatc catgagcagt ttcacacagt actccagcac ccaccaggaa      780
gtccgtggcg gcgacggtgc caaggcacat ggggtgttca gcggcaaaaa agaagatttc      840
caggcctggg tagacagtgt gagcgcctcg ccggacttcg tcgatttcgt ccccaccatc      900
cccatgcagg aaatctggac cctgtgcagc agcgaggcgc aggccgaggc catgcgcaag      960
cattacgatg acgtctgggc gccggcgcaa tcggaaaagt accgggtcaa ggctaactac     1020
atcgaccaac tggtggtcat caccggcggt agttcaacca tcgaaccacc ggtcggctac     1080
agcaagatcg agtacgacct caatgccggt gccggcggtg acttcatcta cttgtgctat     1140
cacgaacaaa cctggcaggc cgacaggcct aaagatgctg tgacggatat caggatcatt     1200
ttcaacaagg agcctacccc acctggctat accaagctgc cccaggacct gaacaagggc     1260
gcgggcggtg atgatgtatt cctctgctac aagaccgagg cttacaacac cgacaccgca     1320
atcaacaagg tcacggtcat cggcggcaac aatgcggata tcaacgctcc ctatggttat     1380
ctgaaggtcc ccggtgacct caacagaggt gctggcggca acttcatcta tgcctgtacc     1440
ttcgtaggca ag                                                         1452

<210>  28
<211>  1449
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  28
atggaacacg tcgacctgcc gacgggactc gtcaaatttt ccagcaatca ccatctgcaa       60
ttgctgcgcg acaccgccga cctcagtgaa tcagtgcttc cgggcgtaga ggccattggc      120
ttgggataca acccattcct cggctacgcc ggtgtgggaa gcggcaccgt ccagcttttc      180
gactggaaca acgcaaaaaa gaaaaaagtg tcattcaaac ccgagttcgt cgtgccggag      240
atcgtcgacg tccagcagaa tgacagcgcc agctacacca acatcagtgg caacaccgtc      300
accgagtatc aacgcagcct ggccgtcagc gtggccatcg aaggcaaata caacttcttc      360
agtggttcgc tttcaaccga ctacgacgaa aactcgctgc gtaatgccga gaacgagttc      420
acccgtatcc agcaatcgat caacctctgg tcgctgcgcc tgccttcggt gaagtcattg      480
cgcgaactga tgctgccgca catgcgtgag caactggatg agctggacgt gaaaaacccg      540
agtgccatca gccggttctt cgaccgggtg ggcagccact tcctcaccgg catcgtgatg      600
ggcggccgag ccatactcgc cgcctcgacc aacaagctca gggtcaagcg tgactactcg      660
gtgtcggtca tcgccaaggc gagctacgaa gggcttaccg gccagttgag cgcagaagcc      720
aaagccaagt atggcgaatc catgagcagt ttcacccagt actccagcac ccaccaggaa      780
gtccgtggcg gcgatggcac caaggcccat ggtgtgttcg agggcaaggc cgggttccag      840
gcctgggtcg acagcgtggg gacctcgccc gatttcgtcg acttcgtgcc caccatcccg      900
atgctggaga tctggagcct gtgcaagacc gattcacagg ctgaagccat gaagcgccat      960
ttcgacacgg tctgggcccg cgaacaatcg gacaagtacc ggataaaggc gaactacatc     1020
gatcagctgg tggtaatcac cggtgacagt tcgaccatag aacctccggc tggctatacc     1080
aagattccct acgacctcaa tgccggggcc aagggcgact tcatctattt gtgctaccac     1140
gaacaagcgt ggtatcccga caacaccaaa cctgccgtca ccgcgatcaa gatcatctac     1200
gaccgggaac cggtacccac cgggtatatc aagctgccgc aagacctcaa caaaggcgca     1260
ggtggcgcgg acatctacct ttgctacaag ctcgagggct acaacaccga taccgcgatc     1320
aacaagatca ccgtgatcag cgggaacaac cccgacatta acgcccccta tggctatgag     1380
aaagtgccgg gcgacctgaa caagggcgca aaaggcaact tcatctatgc ctgcactttc     1440
gtcggcaag                                                             1449

<210>  29
<211>  1449
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  29
atggaacacg tcgacctgcc gacgggactc gtcaaatttt ccagcaatca ccatctgcaa       60
ttgctgcgcg acaccgccga cctcagtgaa tcagtgcttc cgggcgtaga ggccattggc      120
ttgggataca acccattcct cggctacgcc ggtgtgggaa gcggcaccgt ccagcttttc      180
gactggaaca acgcaaaaaa gaaaaaagtg tcattcaaac ccgagttcgt cgtgccggag      240
atcgtcgacg tccagcagaa tgacagcgcc agctacacca acatcagtgg caacaccgtc      300
accgagtatc aacgcagcct ggccgtcagc gtggccatcg aaggcaaata caacttcttc      360
agtggttcgc tttcaaccga ctacgacgaa aactcgctgc gtaatgccga gaacgagttc      420
acccgtatcc agcaatcgat caacctctgg tcgctgcgcc tgccttcggt caaatcactg      480
cgcgacctga tgctgccgca catgcgtgag caactggatg agctggacgt gaaaaacccg      540
agtgccatca gccggttctt cgaccgggtg ggcagccact tcctcaccgg catcgtgatg      600
ggcggccgag ccatactcgc cgcctcgacc aacaaactga aggtcaagcg cgactactcc      660
gtgtcggtca tcgccaaggc gagctacgaa ggcttgaccg gccagctgag cgccgaggcc      720
aggaccaagt acggcgaatc catgagcagt ttcacccagt actccagcac ccaccaggaa      780
gtccgtggcg gcgatggcac caaggcccat ggtgtgttcg agggcaaggc cgggttccag      840
gcctgggtcg acagcgtggg gacctcgccc gatttcgtcg acttcgtgcc caccatcccg      900
atgctggaga tctggagcct gtgcaagacc gattcacagg ctgaagccat gaagcgccat      960
ttcgacacgg tctgggccag cgaacaatcg gacaagtacc ggataaaggc gaactacatc     1020
gatcagctgg tggtaatcac cggtgacagt tcgaccatcg aacctccggc tggctatacc     1080
aagattccct acgacctcaa tgccggggcc aagggcgact tcatctattt gtgctaccac     1140
gaacaagcgt ggtatcccga caacaccaaa cctgccgtca ccgcgatcaa gatcatctac     1200
gaccgggaac cggtacccac cgggtatatc aagctgccgc aggacctgaa caagggcgcg     1260
ggcggtgatg atgtattcct ctgctacaag accgaggctt acaacaccga caccgcaatc     1320
aacaaggtca cggtcatcgg cggcaacaat gcggatatca acgctcccta tggttatctg     1380
aaggtccccg gtgacctaaa cagaggtgct ggcggcaact tcatctatgc ctgtaccttc     1440
gtaggcaag                                                             1449

<210>  30
<211>  1452
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  30
atggaacacg tcgacctgcc gacgggactc gtcaaatttt ccagcaatca ccatctgcaa       60
ttgctgcgcg acaccgccga cctcagtgaa tcagtgcttc cgggcgtaga ggccattggc      120
ttgggataca acccattcct cggctacgcc ggtgtgggaa gcggcaccgt ccagcttttc      180
gactggaaca acgcaaaaaa gaaaaaagtg tcattcaaac ccgagttcgt cgtgccggag      240
atcgtcgacg tccagcagaa tgacagcgcc agctacacca acatcagtgg caacaccgtc      300
accgagtatc aacgcagcct ggccgtcagc gtggccatcg aaggcaaata caacttcttc      360
agtggttcgc tttcaaccga ctactacgaa aactcgctgc gtaatgccga gaacgagttc      420
acccgtatcc agcaatcgat caacctctgg tcgctgcgcc tgccttcggt caaatcactg      480
cgcgacctga tgctgccgca catgcgtgag caactggatg agctggacgt gaaaaacccg      540
agtgccatca gccggttctt cgaccgggtg ggcagccact tccttaccgg catcgtaatg      600
ggtggacggg ccatcatcgc ctcctcgacc aacaagctca gggtcaagcg tgactactcg      660
gtgtcggtgg tcgccaaggc gagctacgaa gggcttaccg gccagttgag cgcagaagcc      720
aaagccaagt atggcgagtc gatcagcagc ttcactcagt actccaatac ccaccaggaa      780
gtgcgcggcg gcgacggtgc caaggcacat ggggtgttca gcggcaaaaa agaagatttc      840
caggcctggg tagacagtgt gagcgcctcg ccggacttcg tcgatttcgt ccccaccatc      900
cccatgcagg aaatctggac cctgtgcaag accgattcac aggctgaagc catgaagcgc      960
catttcgaca cggtctgggc ccgcgaacaa tcggacaagt accggataaa ggcgaactac     1020
atcgatcagc tggtggtaat caccggtgac agttcgacca tcgaacctcc ggctggctat     1080
accaagattc cctacgacct caatgccggg gccaagggcg acttcatcta tttgtgctac     1140
cacgaacaag cgtggtatcc cgacaacacc aaacctgccg tcaccgcgat aaagatcatc     1200
tacgaccggg aaccggtacc caccgggtat atcaagctgc cgcaagacct caacaaaggc     1260
gcaggtggcg cggacatcta cctttgctac aagctcgagg gctacaacac cgataccgcg     1320
atcaacaaga tcaccgtgat cagcgggaac aaccccgaca ttaacgcccc ctatggctat     1380
gagaaagtgc cgggcgacct gaacaagggc gcaaaaggca acttcatcta tgcctgcact     1440
ttcgtcggca ag                                                         1452

<210>  31
<211>  1449
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  31
atggaacacg tcgacctgcc gacgggactc gtcaaatttt ccagcaatca ccatctgcaa       60
ttgctgcgcg acaccgccga cctcagtgaa tcagtgcttc cgggcgtaga ggccattggc      120
ttgggataca acccattcct cggctacgcc ggtgtgggaa gcggcaccgt ccagcttttc      180
gactggaaca acgcaaaaaa gaaaaaagtg tcattcaaac ccgagttcgt cgtgccggag      240
atcgtcgacg tccagcagaa tgacagcgcc agctacacca acatcagtgg caacaccgtc      300
accgagtatc aacgcagcct ggccgtcagc gtggccatcg aaggcaaata caacttcttc      360
agtggttcgc tttcaaccga ctacgacgaa aactcgctga gtaatgccga gaacgagttc      420
acccgtatcc agcaatcgat caacctctgg tcgctgcgcc tgccttcggt caaatcactg      480
cgcgacctga tgctgccgca catgcgtgag caactggatg agctggacgt gaaaaacccg      540
agtgccatca gccggttctt cgaccgggtg ggcagccact tcctcaccgg catcgtgatg      600
ggcggccgag ccatactcgc cgcctcgacc aacaaactga aggtcaagcg cgactactcc      660
gtgtcggtca tcgccaaggc gagctacgaa ggcttgaccg gccagctgag cgccgaggcc      720
aggaccaagt acggcgaatc catgagcagt ttcacccagt actccagcac ccaccaggaa      780
gtccgtggcg gcgatggcac caaggcccat ggtgtgttcg agggcaaggc cgggttccag      840
gcctgggtcg acagcgtggg gacctcgccc gatttcgtcg acttcgtgcc caccatcccg      900
atgctggaga tctggagcct gtgcaagacc gattcacagg ctgaagccat gaagcgccat      960
ttcgacacgg tctgggcccg cgaacaatcg gacaagtacc ggataaaggc gaactacatc     1020
gatcagctgg tggtaatcac cggtgacagt tcgaccatcg aaccaccggt cggctacagc     1080
aagatcgagt acgacctcaa tgccggggcc aagggcgact tcatctattt gtgctaccac     1140
gaacaagcgt ggtatcccga caacaccaaa cctgccgtca ccgagatcaa gatcatctac     1200
gaccgggaac cggtacccac cgggtatatc aagctgccgc aagacctcaa caaaggcgca     1260
ggtggcgcgg acatctacct ttgctacaag ctcgagggct acaacaccga taccgcgatc     1320
aacaagatca ccgtgatcag cgggaacaac cccgacatta acgcccccta tggctatgag     1380
aaagtgccgg gcgacctgaa caagggcgca aaaggcaact tcatctatgc ctgtaccttc     1440
gtaggcaag                                                             1449

<210>  32
<211>  1449
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  32
atggaacacg tcgacctgcc gacgggactc gtcaaatttt ccagcaatca ccatctgcaa       60
ttgctgcgcg acaccgccga cctcagtgaa tcagtgcttc cgggcgtaga ggccattggc      120
ttgggataca acccattcct cggctacgcc ggtgtgggaa gcggcaccgt ccagcttttc      180
gactggaaca acgcaaaaaa gaaaaaagtg tcattcaaac ccgagttcgt cgtgccggag      240
atcgtcgacg tccagcagaa tgacagcgcc agctacacca acatcagtgg caacaccgtc      300
accgagtatc aacgcagcct ggccgtcagc gtggccatcg aaggcaaata caacttcttc      360
agtggttcgc tttcaaccga ctacgacgaa aactcgctgc gtaatgccga gaacgagttc      420
acccgtatcc agcaatcgat caacctctgg tcgctgcgcc tgccttcggt caaatcactg      480
cgcgacctga tgctgccgca catgcgtgag caactggatg agctggacgt gaaaaacccg      540
agtgccatca gccggttctt cgaccgggtg ggcagccact tcctcaccgg catcgtgatg      600
ggcggccgag ccatactcgc cgcctcgacc aacaaactga aggtcaagcg cgactactcc      660
gtgtcggtgg tcgccaaggc gagctacgaa ggcttgaccg gccagctgag cgccgaggcc      720
aggaccaagt acggcgaatc catgagcagt ttcacccagt actccagcac ccaccaggaa      780
gtccgtggcg gcgatggcac caaggcccat ggtgtgttcg agggcaaggc cgggttccag      840
gcctgggtcg acagcgtggg gacctcgccc gatttcgtcg acttcgtgcc caccatcccg      900
atgctggaga tctggagcct gtgcaagacc gattcacagg ctgaagccat gaagcgccat      960
ttcgacacgg tctgggcccg cgaacaatcg gacaagtacc gggtcaaggc taactacatc     1020
gaccaactgg tggtcatcac cggcggtagt tcaaccatcg aaccaccggt cggctacagc     1080
aagatcgagt acgacctcaa tgccggggcc aagggcgact tcatctattt gtgctaccac     1140
gaacaagcgt ggtatcccga caacaccaaa cctgccgtca ccgcgatcaa gatcatctac     1200
gaccgggaac cggtacccac cgggtatatc aagctgccgc aagacctcaa caaaggcgca     1260
ggtggcgcgg acatctacct ttgctacaag ctcgagggct acaacaccga taccgcgatc     1320
aacaaggtca cggtcatcgg cggcaacaat gcggatatca acgctcccta tggttatctg     1380
aaggtccccg gtgacctcaa cagaggtgct ggcggcaact tcatctatgc ctgcactttc     1440
gtcggcaag                                                             1449

<210>  33
<211>  1452
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  33
atggaacacg tcgacctgcc gacgggactc gtcaaatttt ccagcaatca ccatctgcaa       60
ttgctgcgcg acaccgccga cctcagtgaa tcagtgcttc cgggcgtaga ggccattggc      120
ttgggataca accaattcct cggctacgcc ggtgtgggaa gcggcaccgt ccagcttttc      180
gactggaaca acgcaaaaaa gaaaaaagtg tcattcaaac ccgagttcgt cgtgccggag      240
atcgtcgacg tgcaacagaa cgacagcgca acctacacca acgtcagcgg caacacgatc      300
agcgagtacc agcgcagtct ggctaccagc gtcgccatcg aaggccgtta caacttcttc      360
agtggctcgc tgtccacgga tttcgacagt aattcactgc gcaacgcgga aaacgagttc      420
actcgcattc agcaatcgat caacctctgg tcgttgcgct tgccttcggt gaagtcattg      480
cgcgaactga tgctgccaca catgcgccaa caactagatg aattgaatgt caacgacccg      540
aaggccataa gccgctattt cgatagagtt ggcagccatt tccttaccgg catcgtaatg      600
ggtggacggg ccatcctcgc ctcctcgacc aacaagctca gggtcaagcg tgactactcg      660
gtgtcggtgg tcgccaaggc gagctacgaa gggcttaccg gccagttgag cgcagaagcc      720
aaagccaagt atggcgagtc gatcagcagc ttcactcagt actccaatac ccaccaggaa      780
gtgcgcggcg gcgacggtgc caaggcacat ggggtgttca gcggcaaaaa agaagatttc      840
caggcctggg tagacagtgt gagcgcctcg ccggacttcg tcgatttcgt ccccaccatc      900
cccatgcagg aaatctggac cctgtgcagc agcgaggcgc aggccgaggc catgcgcaag      960
cattacgatg acgtctgggc gccggcgcaa tcggaaaagt accgggtcaa ggctaactac     1020
atcgaccaac tggtggtcat caccggcggt agttcaacca tcgaaccacc ggtcggctac     1080
agcaagatcg agtacgacct caatgccggt gccggcggtg acttcatcta cttgtgctat     1140
cacgaacaaa cctggcaggc cgacaggcct aaagatgctg tgacggatat caggatcatt     1200
ttcaacaagg agcctacccc acctggctat accaagctgc cccaggacct gaacaagggc     1260
gcgggcggtg atgatgtatt cctctgctac aagaccgagg cttacaacac cgacaccgca     1320
atcaacaagg tcacggtcat cggcggcaac aatgcggata tcaacgctcc ctatggttat     1380
ctgaaggtcc ccggtgacct caacagaggt gctggcggca acttcatcta tgcctgcact     1440
ttcgtcggca ag                                                         1452

<210>  34
<211>  1452
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  34
atggaacacg tcgacctgcc gacgggactc gtcaaatttt ccagcaatca ccatctgcaa       60
ttgctgcgcg acaccgccga cctcagtgaa tcagtgcttc cgggcgtaga ggccattggc      120
ttgggataca acccattcct cggctacgcc ggtgtgggaa gcggcaccgt ccagcttttc      180
gactggaaca acgcaaaaaa gaaaaaagtg tcattcaaac ccgagttcgt cgtgccggag      240
atcgtcgacg tccagcagaa tgacagcgcc agctacacca acatcagtgg caacaccgtc      300
accgagtatc aacgcagcct ggccgtcagc gtggccatcg aaggcaaata caacttcttc      360
agtggttcgc tttcaaccga ctacgacgaa aactcgctgc gtaatgccga gaacgagttc      420
acccgtatcc agcaatcgat caacctctgg tcgctgcgcc tgccttcggt caaatcactg      480
cgcgacctga tgctgccgca catgcgtgag caactggatg agctggacgt gaaaaacccg      540
agtgccatca gccggttctt cgaccgggtg ggcagccact tcctcaccgg catcgtgatg      600
ggcggccgag ccatactcgc cgcctcgacc aacaaactga aggtcaagcg cgactactcc      660
gtgtcggtca ttgccaaggc gagctacgaa ggcttgaccg gccagctgag cgccgaggcc      720
aggaccaagt acggcgaatc catgagcagt ttcacccagt actccagcac ccaccaggaa      780
gtgcgcggcg gcgacggtgc caaggcacat ggggtgttca gcggcaaaaa agaagatttc      840
caggcctggg tagacagtgt gagcgcctcg ccggacttcg tcgatttcgt ccccaccatc      900
ccgatgctgg agatctggag cctgtgcaag accgattcac aggctgaagc catgaagcgc      960
catttcgaca cggtctgggc ccgcgaacaa tcggacaagt accggataaa ggcgaactac     1020
atcgatcagc tggtggtaat caccggtgac agttcgacca tcgaacctcc ggctggctat     1080
accaagattc cctacgacct caatgccggg gccaagggcg acttcatcta tttgtgctac     1140
cacgaacaag cgtggtatcc cgacaacacc aaacctgccg tcaccgcgat caagatcatc     1200
tacgaccggg aaccggtacc caccgggtat atcaagctgc cgcaagacct caacaaaggc     1260
gcaggtggcg cggacatcta cctttgctac aagctcgagg gctacaacac cgataccgcg     1320
atcaacaaga tcaccgtgat cagagggaac aaccccgaca ttaacgcccc ctatggctat     1380
gagaaagtgc cgggcgacct gaacaagggc gcaaaaggca acttcatcta tgcctgcact     1440
ttcgtcggca ag                                                         1452

<210>  35
<211>  1449
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  35
atggaacacg tcgacctgcc gacgggactc gtcaaatttt ccagcaatca ccatctgcaa       60
ttgctgcgcg acaccgccga cctcagtgaa tcagtgcttc cgggcgtaga ggccattggc      120
ttgggataca acccattcct cggctacgcc ggtgtgggaa gcggcaccgt ccagcttttc      180
gactggaaca acgcaaaaaa gaaaaaagtg tcattcaaac ccgagttagt cgtgccggag      240
atcgtcgacg tccagcagaa tgacagcgcc agctacacca acatcagtgg caacaccgtc      300
accgagtatc aacgcagcct ggccgtcagc gtcgccatcg aaggccgtta caacttcttc      360
agtggctcgc tgtccacgga tttcgacagt aattcactgc gcaacgcgga aaacgagttc      420
acccgtatcc agcaatcgat caacctctgg tcgctgcgcc tgccttcggt caaatcactg      480
cgcgacctga tgctgccgca catgcgtgag caactggatg agctggacgt gaaaaacccg      540
agtgccatca gccggttctt cgaccgggtg ggcagccact tcctcaccgg catcgtgatg      600
ggcggccgag ccatactcgc cgcctcgacc aacaaactga aggtcaagcg cgactactcc      660
gtgtcggtca tcgccaaggc gagctacgaa ggcttgaccg gccagctgag cgccgaggcc      720
aggaccaagt acggcgaatc catgagcagt ttcacccagt actccagcac ccaccaggaa      780
gtccgtggcg gcgatggcac caaggcccat ggtgtgttcg agggcaaggc cgggttccag      840
gcctgggtcg acagcgtggg gacctcgccc gatttcgtcg acttcgtgcc caccatcccg      900
atgctggaga tctggagcct gtgcaagacc gattcacagg ctgaagccat gaagcgccat      960
ttcgacacgg tctgggcccg cgaacaatcg gacaagtacc ggataaaggc gaactacatc     1020
gatcagctgg tggtaatcac cggtgacagt tcgaccatcg aacctccggc tggctatacc     1080
aagattccct acgacctcaa tgccggggcc aagggcgact tcatctattt gtgctaccac     1140
gaacaagcgt ggtatcccga caacaccaaa cctgccgtca ccgcgatcaa gatcatctac     1200
gaccgggaac cggtacccac cgggtatatc aagctgccgc aagacctcaa caaaggcgca     1260
ggtggcgcgg acatctacct ttgctacaag ctcgagggct acaacaccga taccgcgata     1320
aacaagatca ccgtgatcag cgggaacaac cccgacatta acgcccccta tggctatgag     1380
aaagtgccgg gcgacctgaa caagggcgca aaaggcaact tcatctatgc ctgcactttc     1440
gtcggcaag                                                             1449

<210>  36
<211>  1449
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  36
atggaacacg tagacttgcc acagggactt gtaaactttt ccacgcaaca cctgcaactt       60
attcgtttta aagcaggttt gaatgaaacc gtactacctg gcgtcgaagc cattggactt      120
ggctataacc cattcatcag ttatgccagt gtcaacagcg gcgcggtgca attgttcgac      180
tgggccacgg ccaagaaacg cgaagtgcct ttcagagccg gctacttcgt acccgagatc      240
gtcgacgtcc agcagaacga cagcgcaacc tacaccaacg tcagcggcaa cacgatcagc      300
gagtaccagc gcagtctggc taccagcgtc gccatcgaag gccgttacaa cttcttcagt      360
ggttcgcttt caaccgacta cgacgaaaac tcgctgcgta atgccgagaa cgagttcacc      420
cgtatccagc aatcgatcaa cctctggtcg ctgcgcctgc cttcggtgaa gtcattgcgc      480
gacctgatgc tgccgcacat gcgtgagcaa ctggatgagc tggacgtgaa aaacccgagt      540
gccatcagcc ggttcttcga ccgggtgggc agccacttcc tcaccggcat cgtaatgggt      600
ggacgggcca tactcgccgc ctcgaccaac aagctcaggg tcaagcgtga ctactcggtg      660
tcggtggtcg ccaaggcgag ctacgaaggg cttaccggcc agttgagcgc agaagccaaa      720
gccaagtatg gcgagtcgat cagcagcttc actcagtact ccaataccca ccaggaagtg      780
cgcggcggcg acggtgccaa ggcacatggg gtgttcagcg gcaaaaaaga agatttccag      840
gcctgggtcg acagtgtggg cgcctcgccc gatttcgtcg acttcgttcc caccatcccg      900
atgctggaga tctggagcct gtgcaagacc gattcacagg ctgaagccat gaagcgccat      960
ttcgacacgg tctgggcccg cgaacaatcg gacaagtacc ggataaaggc gaactacatc     1020
gatcagctgg tggtaatcac cggtgacagt tcgaccatcg aacctccggc tggctatacc     1080
aagattccct acgacctcaa tgccggtgcc ggcggtgact tcatctactt gtgctatcac     1140
gaacaaacct ggcaggccga caggcctaaa gatgctgtga cggatatcag gatcattttc     1200
aacaaggagc ctaccccacc tggctatacc aagctgcccc aggacctgaa caagggcgcg     1260
ggcggtgatg atgtattcct ctgctacaag accgaggctt acaacaccga taccgcgatc     1320
aacaagatca ccgtgatcag cgggaacaac cccgacatta acgcccccta tggctatgag     1380
aaagtgccgg gcgacctgaa caagggcgca aaaggcaact tcatctatgc ctgcactttc     1440
gtcggcaag                                                             1449

<210>  37
<211>  1452
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  37
atggaacacg tcgacctgcc gacaggactc gtcaaatttt ccagcaatca ccatctgcaa       60
ttgctgcgcg acaccgccga cctcagtgaa tcagtgcttc cgggcgtaga ggccattggc      120
ttgggataca acccattcct cggctacgcc ggtgtgggaa gcggcaccgt ccagcttttc      180
gactggaaca acgcaaaaaa gaaaaaagtg tcattcaaac ccgagttcgt cgtgcccgag      240
atcgtcgacg tccagcagaa tgacagcgca acctacacca acatcagtgg caacaccgtc      300
accgagtatc aacgcagcct ggccgtcagc gtggccatcg aaggcaaata caacttcttc      360
agtggttcgc tttcaaccga ctacgacgaa aactcgctgc gtaatgccga gaacgagttc      420
acccgtatcc agcaatcgat caacctctgg tcgctgcgcc tgccttcggt gaagtcattg      480
cgcgaactga tgctgccaca catgcgccaa caactagatg aattgaacgt caacgacccg      540
aaggccataa gccgctattt cgatagagtt ggcagccatt tccttaccgg catcgtaatg      600
ggtggccggg ccatcctcgc cgcctcgacc aacaagctca gggtcaagcg tgactactcg      660
gtgtcggtgg tcgccaaggc gagctacgaa ggcttgaccg gccagctgag cgccgaggcc      720
aggaccaagt acggcgaatc catgagcagt ttcacccagt actccaatac ccaccaggaa      780
gtgcgcggcg gcgacggtgc caaggcacat ggggtgttca gcggcaaaaa agaagatttc      840
caggcctggg tagacagcgt gagcacctcg cccgatttcg tcgacttcgt tcccaccatc      900
ccgatgctgg agatctggag cctgtgcaag accgattcac aggctgaagc catgaagcgc      960
catttcgaca cggtctgggc ccgcgaacaa tcggacaagt accggataaa ggcgaactac     1020
atcgatcagc tggtggtaat caccggtgac agttcgacca tcgaacctcc ggctggctat     1080
accaagattc cctacgacct caatgccggg gccaagggcg acttcatcta tttgtgctac     1140
cacgaacaag cgtggtatcc cgacaacacc aaacctgccg tcaccgcgat caagatcatc     1200
tacgaccggg aaccggtacc caccgggtat atcaagctgc cgcaagacct caacaaaggc     1260
gcaggtggcg cggacatcta cctttgctac aagctcgagg gctacaacac cgataccgcg     1320
atcaacaagg tcacggtcat cggcggcaac aatgcggata tcaacgctcc ctatggttat     1380
ctgaaggtcc ccggtgacct caacagaggt gctggcggca acttcatcta tgcctgtacc     1440
ttcgtaggca ag                                                         1452

<210>  38
<211>  1449
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  38
atggaaaacg tcgacctgcc gacgggactc gtcaaatttt ccagcaatca ccatctgcaa       60
ttgctgcgcg acaccgccga cctcagtgaa tcagtgcttc cgggcgtaga ggccattggc      120
ttgggataca acccattcct cggctacgcc ggtgtgggaa gcggcaccgt ccagcttttc      180
gactggaaca acgcaaaaaa gaaaaaagtg tcattcaaac ccgagttcgt cgtaccggag      240
atcgtcgacg tgcaacagaa cgacagcgcc acctacacca acatcagtgg caacaccgtc      300
accgagtatc aacgcagcct ggccgtcagc gtggccatcg aaggcaaata caacttcttc      360
agtggttcgc tttcaaccga ctacgacgaa aactcgctgc gtaatgccga gaacgagttc      420
acccgtatcc agcaatcgat caacctctgg tcgttgcgcc tgccttcggt caaatcactg      480
cgcgacctga tgctgccgca catgcgtgag caactggatg agctggacgt gaaaaacccg      540
agtgccatca gccggttctt cgaccgggtg ggcagccact tccttaccgg catcgtgatg      600
ggtggccgag ccatactcgc ctcctcgacc aacaaactga aggtcaagcg cgactactcc      660
gtgtcggtca tcgccaaggc gagctacgaa ggcttgaccg gccagctgag cgccgaggcc      720
aggaccaagt acggcgaatc catgagcagt ttcacccagt actccagcac ccaccaggaa      780
gtccgtggcg gcgatggcac caaggcccat ggtgtgttcg agggcaaggc cgggttccag      840
gcctgggtag acagtgtggg cacctcgccg gatttcgtcg atttcgttcc caccatcccc      900
atgcaggaaa tctggaccct gtgcagcagc gaggcgcagg ccgaggccat gcgcaagcat      960
tacgatgacg tctgggcgcc ggcgcaatcg gaaaagtacc gggtcaaggc taactacatc     1020
gatcagctgg tggtaatcac cggtgacagt tcgaccatcg aacctccggc tggctatacc     1080
aagattccct acgacctcaa tgccggggcc aagggcgact tcatctattt gtgctacaac     1140
gaacaagcgt ggtatcccga caacaccaaa cctgccgtca ccgcgatcaa gatcatctac     1200
gaccgggaac cggtacccac cgggtatatc aagctgccgc aagacctcaa caaaggcgca     1260
ggtggcgcgg acatctacct ttgctacaag ctcgagggct acaacaccga taccgcaatc     1320
aacaaggtca cggtcatcgg cggcaacaat gcggatatca acgctcccta tggttatctg     1380
aaggtccccg gtgacctcaa cagaggtgct ggcggcaact tcatctatgc ctgtaccttc     1440
gtaggcaag                                                             1449

<210>  39
<211>  1452
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  39
atggaacaca tcgacctgcc gacaggactc gtcaaatttt ccagcaatca ccatctgcaa       60
ttgctgcgcg acaccgccga cctcagtgaa tcagtgcttc cgggcgtaga ggccattggc      120
ttgggataca acccattcct cggctacgcc ggtgtgggaa gcggcaccgt ccagcttttc      180
gactggaaca acgcaaaaaa gaaaaaagtg tcattcaaac ccgagttcgt cgtgccggag      240
atcgtcgacg tgcagcagaa tgacagcgca agctacacca acgtcagcgg caacacgatc      300
agcgagtacc agcgcagtct ggctaccagc gtcgccatcg aaggccgtta caacttcttc      360
agtggctcgc tgtccacgga tttcgacagt aattcactgc gcaacgcgga aaacgagttc      420
actcgcattc agcaatcgat caacctctgg tcgttgcgcc tgccttcggt gaagtcattg      480
cgcgaactga tgctgccaca catgcgccaa caactagatg aattgaacgt caacgacccg      540
aaggccataa gccgctattt cgatagagtt ggcagccatt tccttaccgg catcgtgatg      600
ggcggacgag ccatactcgc ctcctcgacc aacaaactga aggtcaagcg cgactactcc      660
gtgtcggtca tcgccaaggc gagctacgaa ggcttgaccg gccagctgag cgccgaggcc      720
aggaccaagt acggcgagtc gatcagcagc ttcactcagt actccaatac ccaccaggaa      780
gtgcgcggcg gcgacggtgc caaggcacat ggggtgttca gcggcaaaaa agaagatttc      840
caggcctggg tagacagcgt gggcgcctcg ccggatttcg tcgatttcgt ccccaccatc      900
cccatgcagg aaatctggac cctgtgcagc agcgaggcgc aggccgaggc catgcgcaag      960
cattacgatg acgtctgggc gccggcgcaa tcggaaaagt accgggtcaa ggctaactac     1020
atcgaccaac tggtggtcat caccggcggt agttcaacca tcgaaccacc ggtcggctac     1080
agcaagatcg agtacgacct caatgccggt gccggaggtg acttcatcta cttgtgctat     1140
cacgaacaaa cctggcaggc cgacaggcct aaagatgctg tgacggatat caggatcatt     1200
ttcaacaagg agcctacccc acctggctat accaagctgc cccaggacct gaacaagggc     1260
gcgggcggtg atgatgtatt cctctgctac aagaccgagg cttacaacac cgataccgca     1320
atcaacaagg tcacggtcat cggcggcaac aatgcggata tcaacgctcc ctatggttat     1380
ctgaaggtcc ccggtgacct caacagaggt gctggcggca acttcatcta tgcctgtacc     1440
ttcgtaggca ag                                                         1452

<210>  40
<211>  1446
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  40
atggaacacg tagacttgcc acaaggactt gtaaactttt ccacgcaaca cctgcaactt       60
attcgtttta aagcaggttt gaatgaaacc gtactacctg gcgtcgaagc cattggactt      120
ggctataacc cattcatcag ttatgccagt gtcaacagcg gcgcggtgca attgttcgac      180
tgggccacgg ccaagaaacg cgaagtgcct ttcaaagccg gctacttcgt acccgagatc      240
gtcgacgtgc agcagaacga cagcgccagc tacaccaacg tcagcggcaa cacgatcagc      300
gagtaccagc gcagtctggc taccagcgtc gccatcgaag gccgttacaa cttcttcagt      360
ggctcgctgt ccacggattt cgacagtaat tcactgcgca acgcggaaaa cgagttcact      420
cgcattcagc aatcgatcaa cctctggtcg ttgcgcctgc cttcggtcaa atcactgcgc      480
gacctgatgc tgccgcacat gcgtgagcaa ctggatgagc tggacgtgaa aaacccgagt      540
gccatcagcc ggttcttcga ccgggtgggc agccacttcc tcaccggcat cgtaatgggt      600
ggccgggcca tcctcgcctc ctcgaccaac aaactgaagg tcaagcgcga ctactccgtg      660
tcggtcatcg ccaaggcgag ctacgaaggc ttgaccggcc agctgagcgc cgaggccagg      720
accaagtacg gcgaatccat gagcagtttc acccagtact ccagcaccca ccaggaagtc      780
cgtggcggcg atggcaccaa ggcccatggt gtgttcgagg gcaaggccgg gttccaggcc      840
tgggtagaca gcgtgggcac ctcgcccgac ttcgtcgact tcgttcccac catcccgatg      900
ctggagatct ggagcctgtg caagaccgat tcacaggctg aagccatgaa gcgccatttc      960
gacacggtct gggcccgcga acaatcggac aagtaccgga taaaggcgaa ctacatcgat     1020
cagctggtgg taatcaccgg tgacagttcg accatcgaac ctccggctgg ctataccaag     1080
attccctacg acctcaatgc cggtgccaag ggcgacttca tctatttgtg ctaccacgaa     1140
caagcgtggt atcccgacaa caccaaacct gccgtcaccg cgatcaagat catctacgac     1200
cgggaaccgg tacccaccgg gtatatcaag ctgccgcaag acctcaacaa aggcgcaggt     1260
ggcgcggaca tctacctttg ctacaagacc gaggcttaca acaccgacac cgcgatcaac     1320
aaggtcacgg tcatcggcgg caacaatgcg gatatcaacg ctccctatgg ttatctgaag     1380
gtccccggtg acctcaacag aggtgctggc ggcaacttca tctatgcctg taccttcgta     1440
ggcaag                                                                1446

<210>  41
<211>  1449
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  41
atggaacacg tcgacctgcc gacaggactc gtcaaatttt ccagcaatca ccatctgcaa       60
ttgctgcgcg acaccgccga cctcagtgaa tcagtgcttc cgggcgtaga ggccattggc      120
ttgggataca acccattcct cggctacgcc ggtgtgggaa gcggcaccgt ccagcttttc      180
gactggaaca acgcaaaaaa gaaaaaagtg tcattcaaac ccgagttcgt cgtgccggag      240
atcgtcgacg tccagcagaa cgacagcgca acctacacca acatcagtgg caacaccgtc      300
accgagtatc aacgcagcct ggccgtcagc gtggccatcg aaggcaaata caacttcttc      360
agtggttcgc tttcaaccga ctacgacgaa aactcgctgc gtaatgccga gaacgagttc      420
acccgtatcc agcaatcgat caacctctgg tcgttgcgcc tgccttcggt caaatcactg      480
cgcgacctga tgctgccgca catgcgtgag caactggatg agctggacgt gaaaaacccg      540
agtgccatca gccggttctt cgaccgggtg ggcagccact tcctcaccgg catcgtgatg      600
ggcggccgag ccatcctcgc ctcctcgacc aacaaactga aggtcaagcg cgactactcc      660
gtgtcggtca tcgccaaggc gagctacgaa ggcttgaccg gccagctgag cgccgaggcc      720
aggaccaagt acggcgaatc catgagcagt ttcacccagt actccagcac ccaccaggaa      780
gtccgtggcg gcgatggcac caaggcccat ggtgtgttcg agggcaaggc cgggttccag      840
gcctgggtcg acagcgtgag cacctcgccc gatttcgtcg acttcgtccc caccatcccc      900
atgcaggaaa tctggaccct gtgcagcagc gaggcgcagg ccgaggccat gcgcaagcat      960
tacgatgacg tctgggcccg cgaacaatcg gacaagtacc ggataaaggc gaactacatc     1020
gatcagctgg tggtaatcac cggtgacagt tcaaccatcg aaccaccggt cggctacagc     1080
aagatcgagt acgacctcaa tgccggggcc aagggcgact tcatctattt gtgctaccac     1140
gaacaagcgt ggtatcccga caacaccaaa cctgccgtca ccgcgatcaa gatcatctac     1200
gaccgggaac cggtacccac cgggtatatc aagctgccgc aagacctcaa caaaggcgca     1260
ggtggcgcgg acatctacct ttgctacaag ctcgagggct acaacaccga caccgcaatc     1320
aacaaggtca cggtcatcgg cggcaacaat gcggatatca acgctcccta tggttatctg     1380
aaggtccccg gtgacctcaa cagaggtgct ggcggcaact tcatctatgc ctgcactttc     1440
gtcggcaag                                                             1449

<210>  42
<211>  1449
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  42
atggaaaacg tagacttgcc acagggactt gtaaactttt ccacgcaaca cctgcaactt       60
attcgtttta aagcaggttt gaatgaaacc gtactacctg gcgtcgaagc cattggactt      120
ggctataacc caatcatcag ttatgccagt gtcaacagcg gcgcggtgca attgttcgac      180
tgggccacgg ccaagaaacg cgaagtgcct ttcaaacccg agttcgtcgt gccggagatc      240
gtcgacgtcc aacagaatga cagcgccacc tacaccaacg tcagcggcaa cacgatcagc      300
gagtaccagc gcagtctggc taccagcgtc gccatcgaag gccgttacaa cttcttcagt      360
ggctcgctgt ccacggattt cgacagtaat tcactgcgca acgcggaaaa cgagttcact      420
cgcattcagc aatcgatcaa cctctggtcg ttgcgcttgc cttcggtgaa gtcattgcgc      480
gaactgatgc tgccacacat gcgccaacaa ctagatgaat tgaacgtcaa cgacccgaag      540
gccataagcc gctatttcga tagagttggc agccatttcc ttaccggcat cgtgatgggc      600
ggccgagcca tcctcgccgc ctcgaccaac aaactgaatg tcaagcgtga ctactcggtg      660
tcggtggtcg ccaaggcgag ctacgaaggg cttaccggcc agttgagcgc agaagccaaa      720
gccaagtatg gcgagtcgat cagcagcttc actcagtact ccaataccca ccaggaagtg      780
cgcggcggcg acggtgccaa ggcacatggg gtgttcagcg gcaaaaaaga agatttccag      840
gcctgggtcg acagtgtggg cgcctcgccc gatttcgtcg atttcgttcc caccatcccg      900
atgctggaga tctggagcct gtgcaagacc gattcacagg ctgaagccat gaagcgccat      960
ttcgacacgg tctgggcccg cgaacaatcg gacaagtacc ggataaaggc gaactacatc     1020
gatcagctgg tggtaatcac cggtgacagt tcgaccatcg aacctccggc tggctatacc     1080
aagattccct acgacctcaa tgccggggcc aagggcgact tcatctattt gtgctaccac     1140
gaacaagcgt ggtatcccga caacaccaaa cctgccgtca ccgcgatcaa gatcatctac     1200
gaccgggaac cggtacccac cgggtatatc aagctgccgc aagacctcaa caaaggcgca     1260
ggtggcgcgg acatctacct ttgctacaag ctcgagggct acaacaccga caccgcgatc     1320
aacaagatca ccgtgatcag cgggaacaac cccgacatta acgcccccta tggctatgag     1380
aaagtgccgg gcgacctgaa caagggcgca aaaggcaact tcatctatgc ctgcactttc     1440
gtcggcaag                                                             1449

<210>  43
<211>  1449
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  43
atggaacacg tagacttgcc acagggactt gtaaactttt ccacgcaaca cctgcaactt       60
attcgtttta aagcaggttt gaatgaaacc gtactacctg gcgtcgaagc cattggactt      120
ggctataacc cattcatcag ttatgccagt gtcaacagcg gcgcggtgca attgttcgac      180
tgggccacgg ccaagaaacg cgaagtgcct ttcaaagccg gctacttcgt acccgagatc      240
gtcgacgtgc aacagaacga cagcgccagc tacaccaacg tcagcggcaa cacgatcagc      300
gagtaccagc gcagtctggc taccagcgtc gccatcgaag gccgttacaa cttcttcagt      360
ggctcgctgt ccacggattt cgacagtaat tcactgcgca acgcggaaaa cgagttcact      420
cgcattcagc aatcgatcaa cctctggtcg ctgcgcctgc cttcggtcaa atcactgcgc      480
gacctgatgc tgccgcacat gcgtgagcaa ctggatgagc tggacgtgaa aaacccgagt      540
gccatcagcc ggttcttcga ccgggtgggc agccacttcc tcaccggcat cgtgatgggt      600
ggccgggcca tcctcgccgc ctcgaccaac aaactgaagg tcaagcgtga ctactcggtg      660
tcggtggtcg ccaaggcgag ctacgaaggg cttaccggcc agctgagcgc cgaggccagg      720
accaagtacg gcgaatccat gagcagtttc acccagtact ccagcaccca ccaggaagtc      780
cgtggcggcg acggtgccaa ggcacatggg gtgttcagcg gcaaaaaaga agatttccag      840
gcctgggtag acagtgtgag cgcctcgccg gatttcgtcg acttcgttcc caccatcccc      900
atgcaggaaa tctggaccct gtgcagcagc gaggcgcagg ccgaggccat gcgcaagcat      960
tacgatgacg tctgggcgcc ggcgcaatcg gaaaagtacc gggtcaaggc taactacatc     1020
gaccaactgg tggtcatcac cggcggtagt tcaactatcg aaccaccggt cggctacagc     1080
aagatcgagt acgacctcaa tgccggtgcc ggcggtgact tcatctactt gtgctatcac     1140
gaacaaacct ggcaggccga caggcctaaa gatgctgtga cggatatcag gatcattttc     1200
aacaaggagc ctaccccacc tggctatacc aagctgcccc aggacctgaa caagggcgcg     1260
ggcggtgatg atgtattcct ctgctacaag accgaggctt acaacaccga taccgcgatc     1320
aacaaggtca cggtcatcgg cggcaacaat gcggatatca acgctcccta tggttatctg     1380
aaggtccccg gtgacctcaa cagaggtgct ggcggcaact tcatctatgc ctgcactttc     1440
gtcggcaag                                                             1449

<210>  44
<211>  1446
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  44
atggaacacg tagacttgcc acagggactt gtaaactttt ccacgcaaca cctgcaactt       60
attcgtctta aagcaggttt gaatgaaacc gtactacctg gcgtcgaagc cattggactt      120
ggctataacc cattcatcag ttatgccagt gtcaacagcg gcgcggtgca attgttcgac      180
tgggccacgg ccaagaaacg cgaagtgcct ttcaaagccg gctacttcgt acccgagatc      240
gtcgacgtgc aacagaatga cagcgcaacc tacaccaaca tcagtggcaa caccgtcacc      300
gagtatcaac gcagcctggc cgtcagcgtg gccatcgaag gcaaatacaa cttcttcagt      360
ggttcgcttt caaccgacta cgacgaaaac tcgctgcgta atgccgagaa cgagttcacc      420
cgtatccagc aatcgatcaa cctctggtcg ctgcgcttgc cttcggtgaa gtcattgcgc      480
gaactgatgc tgccacacat gcgccaacaa ctagatgaat tgaacgtcaa cgacccgaag      540
gccataagcc gctatttcga tagagttggc agccatttcc ttaccggcat cgtgatgggc      600
ggccgggcca tactcgcctc ctcgaccaac aaactgaagg tcaagcgcga ctactccgtg      660
tcggtcatcg ccaaggcgag ctacgaaggc ttgaccggcc agctgagcgc cgaggccagg      720
accaagtacg gcgaatccat gagcagtttc acccagtact ccagcaccca ccaggaagtc      780
cgtggcggcg atggcaccaa ggcccatggt gtgttcgagg gcaaggccgg gttccaggcc      840
tgggtagaca gcgtgagcgc ctcgcccgat ttcgtcgact tcgttcccac catccccatg      900
caggaaatct ggaccctgtg cagctgcgag gcgcaggccg aggccatgcg caagcattac      960
gatgacgtct gggcgccggc gcaatcggaa aagtaccggg tcaaggctaa ctacatcgac     1020
caactggtgg tcatcaccgg cggtagttca accatcgaac caccggtcgg ctacagcaag     1080
atcgagtacg acctcaatgc cggtgccggc ggtgacttca tctacttgtg ctatcacgaa     1140
caaacctggc aggccgacag gcctaaagat gctgtgacgg atatcaggat cattttcaac     1200
aaggagccta ccccacctgg ctataccaag ctgccccagg acctgaacaa gggcgcgggc     1260
ggtgatgatg tattcctctg ctacaagacc gaggcttaca acaccgatac cgcaatcaac     1320
aagatcaccg tgatcagcgg gaacaacccc gacattaacg ccccctatgg ctatgagaaa     1380
gtgccgggcg acctgaacaa gggcgcaaaa ggcaacttca tctatgcctg cactttcgtc     1440
ggcaag                                                                1446

<210>  45
<211>  1449
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  45
atggaaaaca tcgacctgcc gacaggactc gtcaaatttt ccagcaatca ccatctgcaa       60
ttgctgcgcg acaccgccga cctcagtgaa tcagtgcttc cgggcgtaga ggccattggc      120
ttgggataca acccattcct cggctacgcc ggtgtgggaa gcggcaccgt ccagcttttc      180
gactggaaca acgcaaaaaa gaaaaaagtg tcattcaaac ccgagttcgt cgtacccgag      240
atcgtcgacg tccaacagaa tgacagcgcc acctacacca acgtcagcgg caacacgatc      300
agcgagtacc agcgcagtct ggctaccagc gtcgccatcg aaggccgtta caacttcttc      360
agtggctcgc tgtccacgga tttcgacagt aattcactgc gcaacgcgga aaacgagttc      420
actcgcattc agcaatcgat caacctctgg tcgttgcgcc tgccttcggt caaatcactg      480
cgcgacctga tgctgccaca catgcgtgag caactggatg agctggacgt gaaaaacccg      540
agtgccatca gccggttctt cgaccgggtg ggcagccact tcctcaccgg catcgtgatg      600
ggtggacgag ccatcctcgc cgcctcgacc aacaaactga aggtcaagcg cgactactcc      660
gtgtcggtca tcgccaaggc gagctacgaa ggcttgaccg gccagctgag cgccgaggcc      720
aggaccaagt acggcgaatc catgagcagt ttcacccagt actccagaac ccaccaggag      780
gtccgtggcg gcgatggcac caaggcccat ggtgtgttcg agggcaaggc cgggttccag      840
gcctgggtag acagtgtgag cgcctcgccg gatttcgtcg atttcgtccc caccatcccg      900
atgctggaga tctggagcct gtgcaagacc gattcacagg ctgaagccat gaagcgccat      960
ttcgacacgg tctgggcccg cgaacaatcg gacaagtacc ggataaaggc gaactacatc     1020
gatcagctgg tggtcatcac cggtgacagt tcgaccatcg aacctccggc tggttatacc     1080
aagattccct acgacctcaa tgccggtgcc ggcggtgact tcatctattt gtgctaccac     1140
gaacaagcgt ggtatcccga caacaccaaa cctgccgtca ccgcgatcaa gatcatctac     1200
gaccgggaac cggtacccac cgggtatatc aagctgccgc aagacctcaa caaaggcgca     1260
ggtggcgcgg acatctacct ttgctacaag ctcgagggct acaacaccga caccgcaatc     1320
aacaaggtca cggtcatcgg cggcaacaat gcggatatca acgctcccta tggttatctg     1380
aaggtccccg gtgacctcaa cagaggtgct ggcggcaact tcatctatgc ctgtaccttc     1440
gtaggcaag                                                             1449

<210>  46
<211>  1449
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  46
atggaaaaca tagacttgcc acaaggactt gtaaactttt ccacgcaaca cctgcaactt       60
attcgtttta aagcaggttt gaatgaaacc gtactacctg gcgtcgaagc cattggactt      120
ggctataacc cattcatcag ttatgccagt gtcaacagcg gcgcggtgca attgttcgac      180
tgggccacgg ccaagaaacg cgaagtgcct ttcaaagccg gctacttcgt acccgagatc      240
gtcgacgtgc aacagaacga cagcgcaacc tacaccaacg tcagcggcaa cacgatcagc      300
gagtaccagc gcagtctggc taccagcgtc gccatcgaag gccgttacaa cttcttcagt      360
ggctcgctgt ccacggattt cgacagtaat tcactgcgca acgcggaaaa cgagttcact      420
cgcattcagc aatcgatcaa cctctggtcg ttgcgcttgc cttcggtgaa gtcattgcgc      480
gaactgatgc tgccacacat gcgccaacaa ctagatgaat tgaacgtcaa cgacccgaag      540
gccataagcc gctatttcga tagagttggc agccatttcc ttaccggcat cgtaatgggt      600
ggacgggcca tcctcgcctc ctcgaccaac aagctcaggg tcaagcgtga ctactcggtg      660
tcggtggtcg ccaaggcgag ctacgaaggt ctgaccggcc agctgagcgc agaagcccgt      720
accaagtatg gcgagtctat gagcagcttc actcagtact ccaataccca ccaggaagtg      780
cgcggcggcg acggtgccaa ggcacatggg gtgttcagcg gcaaaaaaga agatttccag      840
gcctgggtag acagtgtgag cgcctcgccg gacttcgtcg atttcgtccc caccatcccc      900
atgcaggaaa tctggaccct gtgcagcagc gaggcgcagg ccgaggccat gcgcaagcat      960
tacgatgacg tctgggcgcc ggcgcaatcg gaaaagtacc gggtcaaggc taactacatc     1020
gaccaactgg tggtcatcac cggcgatagc tctaccatcg aaccaccggc cggctacacc     1080
aagatcccgt acgacctgaa tgccggtgcc aaaggtgact tcatctacct gtgctatcac     1140
gaacaagcct ggtaccctga caacactaaa cctgctgtga cggatatcag gatcattttc     1200
aacaaggagc ctaccccacc tggctatacc aagctgcccc aggacctgaa caagggcgcg     1260
ggcggtgatg atgtattcct ctgctacaag accgaggctt acaacaccga caccgcaatc     1320
aacaaggtca cggtcatcgg cggcaacaat gcggatatca acgctcctta tggttatgag     1380
aaggtccctg gtgacctcaa cagaggtgct ggcggcaact tcatctatgc ctgtaccttc     1440
gtaggcaag                                                             1449

<210>  47
<211>  1449
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  47
atggaaaaca tagacttgcc acaaggactt gtaaactttt ccacgcaaca cctgcaactt       60
attcgtttta aagcaggttt gaatgaaacc gtactacctg gcgtcgaagc cattggactt      120
ggctataacc cattcatcag ttatgccagt gtcaacagcg gcgcggtgca attgttcgac      180
tgggccacgg ccaagaaacg cgaagtgcct ttcaaagccg gctacttcgt acccgagatc      240
gtcgacgtgc aacagaacga cagcgcatcc tacaccaaca tcagcggcaa cacggtcacc      300
gagtaccagc gcagcctggc tgtcagcgtc gccatcgaag gcaaatacaa cttcttcagc      360
ggctctctgt ccacggatta cgacgaaaat tctctgcgca acgcggaaaa cgagttcact      420
cgcattcagc aatctatcaa cctgtggtct ctgcgcctgc cttctgtgaa gtctctgcgc      480
gacctgatgc tgccacacat gcgcgaacaa ctggatgaac tggacgtcaa aaacccgagc      540
gccatcagcc gctttttcga tcgtgttggc agccatttcc tgaccggcat cgtaatgggt      600
ggacgggcca tcctcgcctc ctcgaccaac aagctcaggg tcaagcgtga ctactcggtg      660
tcggtggtcg ccaaggcgag ctacgaaggg cttaccggcc agttgagcgc agaagccaaa      720
gccaagtatg gcgagtcgat cagcagcttc actcagtact ccaataccca ccaggaagtg      780
cgcggcggcg acggtgccaa ggcacatggg gtgttcagcg gcaaaaaaga agatttccag      840
gcctgggtag acagtgtgag cgcctcgccg gacttcgtcg atttcgtccc taccatccct      900
atgctggaaa tctggtccct gtgcaaaacc gactctcagg ccgaggccat gaaacgtcat      960
ttcgataccg tctgggcgcg tgagcaatct gacaagtacc gtatcaaggc taactacatc     1020
gaccaactgg tggtcatcac cggcggtagt tcaaccatcg aaccaccggt cggctacacc     1080
aagatcccgt acgacctgaa tgccggtgcc aaaggtgact tcatctacct gtgctatcac     1140
gaacaagcct ggtaccctga caacactaaa cctgctgtga cggctatcaa gatcatttac     1200
gaccgtgagc ctgtcccaac tggctatacc aagctgcccc aggacctgaa caagggcgcg     1260
ggcggtgatg atgtattcct ctgctacaag accgaggctt acaacaccga caccgcaatc     1320
aacaaggtca cggtcatcgg cggcaacaat gcggatatca acgctcccta tggttatctg     1380
aaggtccccg gtgacctcaa cagaggtgct ggcggcaact tcatctatgc ctgtaccttc     1440
gtaggcaag                                                             1449

<210>  48
<211>  1446
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  48
atggaaaaca tagacttgcc acaaggactt gtaaactttt ccacgcaaca cctgcaactt       60
attcgtttta aagcaggttt gaatgaaacc gtactacctg gcgtcgaagc cattggactt      120
ggctataacc cattcatcag ttatgccagt gtcaacagcg gcgcggtgca attgttcgac      180
tgggccacgg ccaagaaacg cgaagtgcct ttcaaagccg gctacttcgt acccgagatc      240
gtcgacgtgc aacagaacga cagcgcatcc tacaccaaca tcagcggcaa cacggtcacc      300
gagtaccagc gcagcctggc tgtcagcgtc gccatcgaag gcaaatacaa cttcttcagc      360
ggctctctgt ccacggatta cgacgaaaat tctctgcgca acgcggaaaa cgagttcact      420
cgcattcagc aatctatcaa cctgtggtct ctgcgcctgc cttctgtgaa gtctctgcgc      480
gacctgatgc tgccacacat gcgcgaacaa ctggatgaac tggacgtcaa aaacccgagc      540
gccatcagcc gctttttcga tcgtgttggc agccatttcc ttaccggcat cgtaatgggt      600
ggacgggcca tcctcgcctc ctcgaccaac aagctcaggg tcaagcgtga ctactctgtg      660
tcggtggtcg ccaaggcgag ctacgaaggg cttaccggcc agctgagcgc agaagcccgt      720
accaagtatg gcgagtctat gagcagcttc actcagtact ccagcaccca ccaggaagtg      780
cgcggcggcg acggtaccaa ggcacatggt gtgttcgaag gcaaagcagg tttccaggcc      840
tgggtagaca gcgtgggcac ctctccggac ttcgtcgatt tcgtccccac catccccatg      900
caggaaatct ggaccctgtg caaaaccgac tctcaggccg aggccatgaa acgtcatttc      960
gataccgtct gggcgcgtga gcaatctgac aagtaccgta tcaaggctaa ctacatcgac     1020
caactggtgg tcatcaccgg cgatagctct accatcgaac caccggccgg ctacaccaag     1080
atcgagtacg acctgaatgc cggtgccaaa ggtgacttca tctacctgtg ctatcacgaa     1140
caagcctggt accctgacaa cactaaacct gctgtgacgg ctatcaagat cattttcaac     1200
aaggagccta ccccacctgg ctataccaag ctgcctcagg acctgaacaa gggcgcgggc     1260
ggtgatgatg tattcctctg ctacaagacc gaggcttaca acaccgacac cgcaatcaac     1320
aaggtcacgg tcatcggcgg caacaatgcg gatatcaacg ctccctatgg ttatctgaag     1380
gtccccggtg acctcaacag aggtgctggc ggcaacttca tctatgcctg taccttcgta     1440
ggcaag                                                                1446

<210>  49
<211>  1452
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  49
atggaacacg tagacctgcc aacgggtctg gtaaaatttt cctctaatca ccacctgcaa       60
ctgctgcgtg atacggcaga tctgagcgaa tccgtactgc ctggcgtcga agccattggt      120
ctgggctata acccattcct gggttatgcc ggtgtcggca gcggcacggt gcaactgttc      180
gactggaaca acgccaagaa aaaaaaagtg tctttcaaac ctgaattcgt cgtacctgag      240
atcgtcgacg tgcaacagaa cgacagcgca tcctacacca acatcagcgg caacacggtc      300
accgagtacc agcgcagcct ggctgtcagc gtcgccatcg aaggcaaata caacttcttc      360
agcggctctc tgtccacgga ttacgacgaa aattctctgc gcaacgcgga aaacgagttc      420
actcgcattc agcaatcgat caacctctgg tcgttgcgct tgccttcggt gaagtcattg      480
cgcgaactga tgctgccaca catgcgccaa caactagatg aattgaacgt caacgacccg      540
aaggccataa gccgctattt cgatcgtgtt ggcagccatt tcctgaccgg catcgtaatg      600
ggtggtcgtg ccatcctggc cgcctctacc aacaagctca gggtcaagcg tgactactcg      660
gtgtcggtgg tcgccaaggc gagctacgaa ggtctgaccg gccagctgag cgcagaagcc      720
cgtaccaagt atggcgagtc tatgagcagc ttcactcagt actccagcac ccaccaggaa      780
gtgcgcggcg gcgacggtgc caaggcacat ggggtgttca gcggcaaaaa agaagatttc      840
caggcctggg tagacagcgt gggcacctct tcggacttcg tcgatttcgt ccctaccatc      900
cctatgctga aaatctggtc cctgtgcaaa accgactctc aggccgaggc catgaaacgt      960
catttcgata ccgtctgggc gcgtgagcaa tctgacaagt accgtatcaa ggctaactac     1020
atcgaccaac tggtggtcat caccggcggt agttcaacca tcgaaccacc ggtcggctac     1080
agcaagatcg agtacgacct gaatgccggt gccggcggtg acttcatcta cttgtgctat     1140
cacgaacaaa cctggcaggc cgacaggcct aaagatgctg tgacggatat caggatcatt     1200
ttcaacaagg agcctacccc acctggctat accaagctgc cccaggacct gaacaagggc     1260
gcgggcggtg atgatgtatt cctctgctac aagaccgagg cttacaacac cgacaccgca     1320
atcaacaagg tcacggtcat cggcggcaac aatgcggata tcaacgctcc ctatggttat     1380
ctgaaggtcc ccggtgacct caacagaggt gctggcggca acttcatcta tgcctgtacc     1440
ttcgtaggca ag                                                         1452

<210>  50
<211>  1449
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  50
atggaacacg tagacctgcc aacgggtctg gtaaaatttt cctctaatca ccacctgcaa       60
ctgctgcgtg atacggcaga tctgagcgaa tccgtactgc ctggcgtcga agccattggt      120
ctgggctata acccattcct gggttatgcc ggtgtcggca gcggcacggt gcaactgttc      180
gactggaaca acgccaagaa aaaaaaagtg tctttcaaac ctgaattcgt cgtacctgag      240
atcgtcgacg tgcaacagaa cgacagcgca tcctacacca acatcagcgg caacacgatc      300
agcgagtacc agcgcagtct ggctaccagc gtcgccatcg aaggccgtta caacttcttc      360
agtggctcgc tgtccacgga tttcgacagt aattcactgc gcaacgcgga aaacgagttc      420
actcgcattc agcaatcgat caacctctgg tcgttgcgct tgccttcggt gaagtcattg      480
cgcgaactga tgctgccaca catgcgccaa caactagatg aattgaacgt caacgacccg      540
aaggccataa gccgctattt cgatagagtt ggcagccatt tccttaccgg catcgtaatg      600
ggtggacggg ccatcctcgc ctcctcgacc aacaagctca gggtcaagcg tgactactcg      660
gtgtcggtgg tcgccaaggc gagctacgaa gggcttaccg gccagctgag cgcagaagcc      720
cgtaccaagt atggcgagtc tatgagcagc ttcactcagt actccagcac ccaccaggaa      780
gtgcgcggcg gcgacggtac caaggcacat ggtgtgttcg aaggcaaagc aggtttccag      840
gcctgggtag acagcgtggg cacctctccg gacttcgtcg atttcgtccc taccatccct      900
atgctggaaa tctggtccct gtgcaaaacc gactctcagg ccgaggccat gaaacgtcat      960
ttcgataccg tctgggcgcg tgagcaatct gacaagtacc gtatcaaggc taactacatc     1020
gaccaactgg tggtcatcac cggcggtagt tcaaccatcg aaccaccggt cggctacagc     1080
aagatcgagt acgacctcaa tgccggtgcc ggcggtgact tcatctactt gtgctatcac     1140
gaacaaacct ggcaggccga caggcctaaa gatgctgtga cggatatcag gatcattttc     1200
aacaaggagc ctaccccacc tggctatacc aagctgcccc aggacctgaa caagggcgcg     1260
ggcggtgatg atgtattcct ctgctacaag accgaggctt acaacaccga caccgcaatc     1320
aacaaggtca cggtcatcgg cggcaacaat gcggatatca acgctcccta tggttatctg     1380
aaggtccctg gtgacctgaa caaaggtgct aaaggcaact tcatctatgc ctgtaccttc     1440
gtaggcaag                                                             1449

<210>  51
<211>  1446
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  51
atggaaaaca tagacttgcc acaaggactt gtaaactttt ccacgcaaca cctgcaactt       60
attcgtttta aagcaggttt gaatgaaacc gtactacctg gcgtcgaagc cattggactt      120
ggctataacc cattcatcag ttatgccagt gtcaacagcg gcacggtgca actgttcgac      180
tgggccacgg ccaagaaacg cgaagtgcct ttcaaagccg gctacttcgt acccgagatc      240
gtcgacgtgc aacagaacga cagcgcaacc tacaccaacg tcagcggcaa cacgatcagc      300
gagtaccagc gcagtctggc taccagcgtc gccatcgaag gccgttacaa cttcttcagc      360
ggctctctgt ccacggattt cgacagtaat tcactgcgca acgcggaaaa cgagttcact      420
cgcattcagc aatctatcaa cctgtggtct ctgcgcctgc cttctgtgaa gtctctgcgc      480
gacctgatgc tgccacacat gcgcgaacaa ctggatgaac tggacgtcaa aaacccgagc      540
gccatcagcc gctttttcga tcgtgttggc agccatttcc ttaccggcat cgtaatgggt      600
ggacgggcca tcctcgcctc ctcgaccaac aagctcaggg tcaagcgtga ctactcggtg      660
tcggtggtcg ccaaggcgag ctacgaaggg cttaccggcc agctgagcgc agaagcccgt      720
accaagtatg gcgagtctat gagcagcttc actcagtact ccagcaccca ccaggaagtg      780
cgcggcggcg acggtaccaa ggcacatggt gtgttcgaag gcaaagcagg tttccaggcc      840
tgggtagaca gcgtgggcac ctctccggac ttcgtcgatt tcgtccctac catccctatg      900
ctggaaatct ggtccctgtg caaaaccgac tctcaggccg aggccatgaa acgtcatttc      960
gataccgtct gggcgcgtga gcaatctgac aagtaccgta tcaaggctaa ctacatcgac     1020
caactggtgg tcatcaccgg cgatagctct accatcgaac caccggccgg ctacaccaag     1080
atcccgtacg acctgaatgc cggtgccggc ggtgacttca tctacttgtg ctatcacgaa     1140
caaacctggc aggccgacag gcctaaagat gctgtgacgg atatcaagat catttacgac     1200
cgtgagcctg tcccaactgg ctatatcaag ctgcctcagg acctgaacaa gggcgcgggc     1260
ggtgctgata tctacctgtg ctacaagctg gagggttaca acaccgacac cgcaatcaac     1320
aaggtcacgg tcatcggcgg caacaatgcg gatatcaacg ctccctatgg ttatctgaag     1380
gtccccggtg acctcaacag aggtgctggc ggcaacttca tctatgcctg taccttcgta     1440
ggcaag                                                                1446

<210>  52
<211>  1449
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  52
atggaaaaca tagacttgcc acaaggactt gtaaactttt ccacgcaaca cctgcaactt       60
attcgtttta aagcaggttt gaatgaaacc gtactacctg gcgtcgaagc cattggactt      120
ggctataacc cattcatcag ttatgccagt gtcaacagcg gcgcggtgca attgttcgac      180
tgggccacgg ccaagaaacg cgaagtgcct ttcaaagccg gctacttcgt acccgagatc      240
gtcgacgtgc aacagaacga cagcgcaacc tacaccaacg tcagcggcaa cacgatcagc      300
gagtaccagc gcagtctggc taccagcgtc gccatcgaag gccgttacaa cttcttcagt      360
ggctcgctgt ccacggattt cgacagtaat tcactgcgca acgcggaaaa cgagttcact      420
cgcattcagc aatcgatcaa cctctggtcg ttgcgcctgc cttctgtgaa gtctctgcgc      480
gacctgatgc tgccacacat gcgcgaacaa ctggatgaac tggacgtcaa aaacccgagc      540
gccatcagcc gctttttcga tcgtgttggc agccatttcc tgaccggcat cgtaatgggt      600
ggacgggcca tcctcgcctc ctcgaccaac aagctcaggg tcaagcgtga ctactctgtg      660
tctgtgatcg ccaaggcgag ctacgaaggt ctgaccggcc agctgagcgc agaagcccgt      720
accaagtatg gcgagtctat gagcagcttc actcagtact ccaataccca ccaggaagtg      780
cgcggcggcg acggtgccaa ggcacatggg gtgttcagcg gcaaaaaaga agatttccag      840
gcctgggtag acagtgtgag cgcctcgccg gacttcgtcg atttcgtccc caccatcccc      900
atgcaggaaa tctggaccct gtgcagcagc gaggcgcagg ccgaggccat gcgcaagcat      960
tacgatgacg tctgggcgcc ggcgcaatcg gaaaagtacc gggtcaaggc taactacatc     1020
gaccaactgg tggtcatcac cggcggtagt tcaaccatcg aaccaccggt cggctacagc     1080
aagatcgagt acgacctcaa tgccggtgcc ggcggtgact tcatctactt gtgctatcac     1140
gaacaagcct ggtaccctga caacactaaa cctgctgtga cggctatcaa gatcatttac     1200
gaccgtgagc ctgtcccaac tggctatatc aagctgcctc aggacctgaa caagggcgcg     1260
ggcggtgctg atatctacct gtgctacaag ctggagggtt acaacaccga caccgcaatc     1320
aacaaggtca cggtcatcgg cggcaacaat ccggatatca acgctcctta tggttatgag     1380
aaggtccctg gtgacctgaa caaaggtgct aaaggcaact tcatctatgc ctgtaccttc     1440
gtaggcaag                                                             1449

<210>  53
<211>  1452
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  53
atggaacacg tagacctgcc aacgggtctg gtaaaatttt cctctaatca ccacctgcaa       60
ctgctgcgtg atacggcaga tctgagcgaa tccgtactgc ctggcgtcga agccattggt      120
ctgggctata acccattcct gggttatgcc ggtgtcggca gcggcacggt gcaactgttc      180
gactggaaca acgccaagaa aaaaaaagtg tctttcaaac ctgaattcgt cgtacctgag      240
atcgtcgacg tgcaacagaa cgacagcgca tcctacacca acatcagcgg caacacggtc      300
accgagtacc agcgcagcct ggctgtcagc gtcgccatcg aaggccgtta caacttcttc      360
agtggctcgc tgtccacgga tttcgacagt aattcactgc gcaacgcgga aaacgagttt      420
actcgcattc agcaatcgat caacctctgg tcgttgcgct tgccttcggt gaagtcattg      480
cgcgaactga tgctgccaca catgcgccaa caactagatg aattgaacgt caacgacccg      540
aaggccataa gccgctattt cgatagagtt ggcagccatt tcctgaccgg catcgtaatg      600
ggtggtcgtg ccatcctggc cgcctctacc aacaagctga aggtcaagcg tgactactct      660
gtgtctgtga tcgccaaggc gagctacgaa ggtctgaccg gccagttgag cgcagaagcc      720
aaagccaagt atggcgagtc gatcagcagc ttcactcagt actccaatac ccaccaggaa      780
gtgcgcggcg gcgacggtgc caaggcacat ggggtgttca gcggcaaaaa agaagatttc      840
caggcctggg tagacagtgt gagcgcctcg ccggacttcg tcgatttcgt ccccaccatc      900
cccatgcagg aaatctggac cctgtgcagc agcgaggcgc aggccgaggc catgcgcaag      960
cattacgatg acgtctgggc gccggcgcaa tcggaaaagt accgggtcaa ggctaactac     1020
atcgaccaac tggtggtcat caccggcggt agttcaacca tcgaaccacc ggtcggctac     1080
agcaagatcg agtacgacct caatgccggt gccggcggtg acttcatcta cttgtgctat     1140
cacgaacaaa cctggcaggc cgacaggcct aaagatgctg tgacggatat caggatcatt     1200
ttcaacaagg agcctacccc acctggctat atcaagctgc cccaggacct gaacaagggc     1260
gcgggcggtg atgatgtatt cctctgctac aagaccgagg cttacaacac cgacaccgca     1320
atcaacaagg tcacggtcat cggcggcaac aatccggata tcaacgctcc ttatggttat     1380
ctgaaggtcc ccggtgacct caacagaggt gctggcggca acttcatcta tgcctgtacc     1440
ttcgtaggca ag                                                         1452

<210>  54
<211>  1446
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  54
atggaaaaca tagacttgcc acaaggactt gtaaactttt ccacgcaaca cctgcaactt       60
attcgtttta aagcaggttt gaatgaaacc gtactacctg gcgtcgaagc cattggactt      120
ggctataacc cattcatcag ttatgccagt gtcaacagcg gcgcggtgca attgttcgac      180
tgggccacgg ccaagaaacg cgaagtgtct ttcaaacctg aattcgtcgt acctgagatc      240
gtcgacgtgc aacagaacga cagcgcatcc tacaccaaca tcagcggcaa cacggtcacc      300
gagtaccagc gcagtctggc taccagcgtc gccatcgaag gccgttacaa cttcttcagt      360
ggctcgctgt ccacggattt cgacagtaat tcactgcgca acgcggaaaa cgagttcact      420
cgcattcagc aatcgatcaa cctctggtcg ttgcgcttgc cttcggtgaa gtcattgcgc      480
gaactgatgc tgccacacat gcgccaacaa ctagatgaat tgaacgtcaa cgacccgaag      540
gccataagcc gctatttcga tagagttggc agccatttcc ttaccggcat cgtaatgggt      600
ggacgggcca tcctcgcctc ctcgaccaac aagctcaggg tcaagcgtga ctactcggtg      660
tcggtggtcg ccaaggcgag ctacgaaggg cttaccggcc agttgagcgc agaagccaaa      720
gccaagtatg gcgagtcgat cagcagcttc actcagtact ccagcaccca ccaggaagtg      780
cgcggcggcg acggtaccaa ggcacatggt gtgttcgaag gcaaagcagg tttccaggcc      840
tgggtagaca gcgtgggcac ctctccggac ttcgtcgatt tcgtccctac catccctatg      900
ctggaaatct ggtccctgtg cagcagcgag gcgcaggccg aggccatgcg caagcattac      960
gatgacgtct gggcgccggc gcaatcggaa aagtaccggg tcaaggctaa ctacatcgac     1020
caactggtgg tcatcaccgg cggtagttca accatcgaac caccggtcgg ctacagcaag     1080
atcgagtacg acctcaatgc cggtgccggc ggtgacttca tctacttgtg ctatcacgaa     1140
caaacctggc aggccgacag gcctaaagat gctgtgacgg atatcaggat cattttcaac     1200
aaggagccta ccccacctgg ctataccaag ctgccccagg acctgaacaa gggcgcgggc     1260
ggtgatgatg tattcctctg ctacaagacc gaggcttaca acaccgacac cgcaatcaac     1320
aaggtcacgg tcatcggcgg caacaatgcg gatatcaacg ctccctatgg ttatctgaag     1380
gtccccggtg acctcaacag aggtgctggc ggcaacttca tctatgcctg taccttcgta     1440
ggcaag                                                                1446

<210>  55
<211>  1446
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  55
atggaaaaca tagacttgcc acaaggactt gtaaactttt ccacgcaaca cctgcaactt       60
attcgtttta aagcaggttt gaatgaaacc gtactacctg gcgtcgaagc cattggactt      120
ggctataacc cattcatcag ttatgccagt gtcaacagcg gcgcggtgca attgttcgac      180
tgggccacgg ccaagaaacg cgaagtgcct ttcaaagccg gctacttcgt acccgagatc      240
gtcgacgtgc aacagaacga cagcgcatcc tacaccaaca tcagcggcaa cacggtcacc      300
gagtaccagc gcagcctggc tgtcagcgtc gccatcgaag gcaaatacaa cttcttcagc      360
ggctctctgt ccacggatta cgacgaaaat tctctgcgca acgcggaaaa cgagttcact      420
cgcattcagc aatctatcaa cctgtggtct ctgcgcctgc cttctgtgaa gtctctgcgc      480
gacctgatgc tgccacacat gcgcgaacaa ctggatgaac tggacgtcaa aaacccgagc      540
gccatcagcc gctttttcga tcgtgttggc agccatttcc tgaccggcat cgtaatgggt      600
ggtcgtgcca tcctggccgc ctctaccaac aagctgaagg tcaagcgtga ctactctgtg      660
tctgtgatcg ccaaggcgag ctacgaaggt ctgaccggcc agctgagcgc agaagcccgt      720
accaagtatg gcgagtctat gagcagcttc actcagtact ccagcaccca ccaggaagtg      780
cgcggcggcg acggtaccaa ggcacatggt gtgttcgaag gcaaagcagg tttccaggcc      840
tgggtagaca gcgtgggcac ctctccggac ttcgtcgatt tcgtccctac catccctatg      900
ctggaaatct ggtccctgtg cagcagcgag gcgcaggccg aggccatgcg caagcattac      960
gatgacgtct gggcgccggc gcaatcggaa aagtaccggg tcaaggctaa ctacatcgac     1020
caactggtgg tcatcaccgg cggtagttca accatcgaac caccggtcgg ctacagcaag     1080
atcgagtacg acctcaatgc cggtgccggc ggtgacttca tctacttgtg ctatcacgaa     1140
caaacctggc aggccgacag gcctaaagat gctgtgacgg atatcaggat cattttcaac     1200
aaggagccta ccccacctgg ctataccaag ctgccccagg acctgaacaa gggcgcgggc     1260
ggtgatgatg tattcctctg ctacaagacc gaggcttaca acaccgacac cgcaatcaac     1320
aaggtcacgg tcatcggcgg caacaatgcg gatatcaacg ctccctatgg ttatctgaag     1380
gtccccggtg acctcaacag aggtgctggc ggcaacttca tctatgcctg taccttcgta     1440
ggcaag                                                                1446

<210>  56
<211>  1446
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  56
atggaaaaca tagacttgcc acaaggactt gtaaactttt ccacgcaaca cctgcaactt       60
attcgtttta aagcaggttt gaatgaaacc gtactacctg gcgtcgaagc cattggactt      120
ggctataacc cattcatcag ttatgccagt gtcaacagcg gcgcggtgca attgttcgac      180
tgggccacgg ccaagaaacg cgaagtgcct ttcaaagccg gctacttcgt acccgagatc      240
gtcgacgtgc aacagaacga cagcgcaacc tacaccaacg tcagcggcaa cacgatcagc      300
gagtaccagc gcagtctggc taccagcgtc gccatcgaag gccgttacaa cttcttcagt      360
ggctcgctgt ccacggattt cgacgaaaat tctctgcgca acgcggaaaa cgagttcact      420
cgcattcagc aatcgatcaa cctctggtcg ttgcgcctgc cttctgtgaa gtctctgcgc      480
gacctgatgc tgccacacat gcgccaacaa ctagatgaat tgaacgtcaa cgacccgaag      540
gccataagcc gctatttcga tagagttggc agccatttcc ttaccggcat cgtaatgggt      600
ggacgggcca tcctcgcctc ctcgaccaac aagctcaggg tcaagcgtga ctactcggtg      660
tcggtggtcg ccaaggcgag ctacgaaggg cttaccggcc agttgagcgc agaagccaaa      720
gccaagtatg gcgagtctat gagcagcttc actcagtact ccagcaccca ccaggaagtg      780
cgcggcggcg acggtaccaa ggcacatggt gtgttcgaag gcaaagcagg tttmcaggcc      840
tgggtagaca gcgtgggcac ctstccggay ttcgtcgatt tcgtccccac catccccatg      900
caggaaatct ggtccctgtg caaaaccgac tctcaggccg aggccatgaa acgtcatttc      960
gataccgtct gggcgcgtga gcaatctgac aagtaccgta tcaaggctaa ctacatcgac     1020
caactggtgg tcatcaccgg cgatagctct accatcgaac caccggtcgg ctacagcaag     1080
atcgagtacg acctcaatgc cggtgccggc ggtgacttca tctacttgtg ctatcacgaa     1140
caaacctggc aggccgacag gcctaaagat gctgtgacgg atatcaggat cattttcaac     1200
aaggagccta ccccacctgg ctataccaag ctgccccagg acctgaacaa gggcgcgggc     1260
ggtgctgata tctacctgtg cttcaagctg gagggttaca acaccgacac cgcaatcaac     1320
aagatcacgg tcatcagcgg caacaatccg gatatcaacg ctccttatgg ttatgagaag     1380
gtccctggtg acctgaacaa aggtgataaa ggcaacttca tctatgcctg taccttcgta     1440
ggcaag                                                                1446

<210>  57
<211>  1449
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  57
atggaaaaca tagacttgcc acaaggactt gtaaactttt ccacgcaaca cctgcaactt       60
attcgtttta aagcaggttt gaatgaaacc gtactacctg gcgtcgaagc cattggactt      120
ggctataacc cattcatcag ttatgccagt gtcaacagcg gcgcggtgca attgttcgac      180
tgggccacgg ccaagaaacg cgaagtgcct ttcaaagccg gctacttcgt acccgagatc      240
gtcgacgtgc aacagaacga cagcgcaacc tacaccaacg tcagcggcaa cacgatcagc      300
gagtaccagc gcagtctggc taccagcgtc gccatcgaag gccgttacaa cttcttcagt      360
ggctcgctgt ccacggattt cgacagtaat tcactgcgca acgcggaaaa cgagttcact      420
cgcattcagc aatcgatcaa cctctggtcg ttgcgcttgc cttcggtgaa gtcattgcgc      480
gacctgatgc tgccacacat gcgcgaacaa ctggatgaac tggacgtcaa aaacccgagc      540
gccatcagcc gctttttcga tcgtgttggc agccatttcc tgaccggcat cgtaatgggt      600
ggtcgtgcca tcctggccgc ctctaccaac aagctgaagg tcaagcgtga ctactcggtg      660
tcggtggtcg ccaaggcgag ctacgaaggg ctgaccggcc agctgagcgc agaaacccgt      720
accaagtatg gcgagtctat gagcagcttc actcagtact ccaataccca ccaggaagtg      780
cgcggcggcg acggtgccaa ggcacatggg gtgttcagcg gcaaaaaaga agatttccag      840
gcctgggtag acagtgtgag cgcctcgccg gacttcgtcg atttcgtccc taccatccct      900
atgctggaaa tctggtccct gtgcaaaacc gactctcagg ccgaggccat gaaacgtcat      960
ttcgataccg tctgggcgcg tgagcaatct gacaagtacc gtatcaaggc taactacatc     1020
gaccaactgg tggtcatcac cggcggtagt tcaaccatcg aaccaccggt cggctacagc     1080
aagatcgagt acgacctcaa tgccggtgcc ggcggtgact tcatctactt gtgctatcac     1140
gaacaaacct ggcaggccga caggcctaaa gatgctgtga cggatatcag gatcattttc     1200
aacaaggagc ctaccccacc tggctatacc aagctgcccc aggacctgaa caagggcgcg     1260
ggcggtgatg atatctacct gtgctacaag ctggagggtt acaacaccga caccgcaatc     1320
aacaaggtca cggtcatcgg cggcaacaat gcggatatca acgctcccta tggttatctg     1380
aaggtccccg gtgacctcaa cagaggtgct ggcggcaact tcatctatgc ctgtaccttc     1440
gtaggcaag                                                             1449

<210>  58
<211>  1449
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  58
atggaaaaca tagacttgcc acaaggactt gtaaactttt ccaagcaaca cctgcaactt       60
attcgtttta aagcaggttt gaatgaaacc gtactacctg gcgtcgaagc cattggactt      120
ggctataacc cattcatcag ttatgccagt gtcaacagcg gcgcggtgca attgttcgac      180
tgggccacgg ccaagaaacg cgaagtgcct ttcaaagccg gctacttcgt acccgagatc      240
gtcgacgtgc aacagaacga cagcgcatcc tacaccaaca tcagcggcaa cacggtcacc      300
gagtaccagc gcagcctggc taccagcgtc gccatcgaag gccgttacaa cttcttcagc      360
ggctctctgt ccacggatta cgacgaaaat tctctgcgca acgcggaaaa cgagttcact      420
cgcattcagc aatctatcaa cctgtggtct ctgcgcctgc cttctgtgaa gtctctgcgc      480
gacctgatgc tgccacacat gcgcgaacaa ctggatgaac tggacgtcaa aaacccgagc      540
gccatcagcc gctttttcga tcgtgttggc agccatttcc tgaccggcat cgtaatgggt      600
ggtcgtgcca tcctggccgc ctctaccaac aagctgaagg tcaagcgtga ctactctgtg      660
tcggtggtcg ccaaggcgag ctacgaaggg cttaccggcc agttgagcgc agaagccaaa      720
gccaagtatg gcgagtcgat cagcagcttc actcagtact ccagcaccca ccaggaagtg      780
cgcggcggcg acggtaccaa ggcacatggg gtgttcagcg gcaaaaaaga agatttccag      840
gcctgggtag acagtgtgag cgcctcgccg gacttcgtcg atttcgtccc caccatcccc      900
atgcaggaaa tctggaccct gtgcagcagc gaggcgcagg ccgaggccat gcgcaagcat      960
tacgatgacg tctgggcgcc ggcgcaatcg gaaaagtacc gggtcaaggc taactacatc     1020
gaccaactgg tggtcatcac cggcgatagc tctaccatcg aaccaccggc cggctacacc     1080
aagatcccgt acgacctgaa tgccggtgcc ggcggtgact tcatctactt gtgctatcac     1140
gaacaaacct ggcaggccga caggcctaaa gatgctgtga cggatatcag gatcattttc     1200
aacaaggagc ctaccccacc tggctatacc aagctgcccc aggacctgaa caagggcgcg     1260
ggcggtgatg atgtattcct ctgctacaag accgaggctt acaacaccga caccgcaatc     1320
aacaaggtca cggtcatcgg cggcaacaat gcggatatca acgctcccta tggttatctg     1380
aaggtccccg gtgacctcaa cagaggtgct ggcggcaact tcatctatgc ctgtaccttc     1440
gtaggcaag                                                             1449

<210>  59
<211>  1449
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  59
atggaaaaca tagacttgcc acaaggactt gtaaactttt ccacgcaaca cctgcaactt       60
attcgtttta aagcaggttt gaatgaaacc gtactacctg gcgtcgaagc cattggactt      120
ggctataacc cattcatcag ttatgccagt gtcaacagcg gcgcggtgca attgttcgac      180
tgggccacgg ccaagaaacg cgaagtgcct ttcaaagccg gctacttcgt acccgagatc      240
gtcgacgtgc aacagaacga cagcgcaacc tacaccaaca tcagcggcaa cacgatcagc      300
gagtaccagc gcagtctggc taccagcgtc gccatcgaag gccgttacaa cttcttcagc      360
ggctctctgt ccacggatta cgacgaaaat tctctgcgca acgcggaaaa cgagttcact      420
cgcattcagc aatctatcaa cctgtggtct ctgcgcctgc cttctgtgaa gtctctgcgc      480
gacctgatgc tgccacacat gcgcgaacaa ctggatgaac tggacgtcaa aaacccgaag      540
gccataagcc gctatttcga tagagttggc agccatttcc tgaccggcat cgtaatgggt      600
ggtcgtgcca tcctggccgc ctctaccaac aagctgaagg tcaagcgtga ctactctgtg      660
tctgtgatcg ccaaggcgag ctacgaaggt ctgaccggcc agttgagcgc agaagccaaa      720
gccaagtatg gcgagtcgat cagcagcttc actcagtact ccaataccca ccaggaagtg      780
cgcggcggcg acggtgccaa ggcacatggg gtgttcagcg gcaaaaaaga agatttccag      840
gcctgggtag acagtgtgag cgcctcgccg gacttcgtcg atttcgtccc caccatcccc      900
atgcaggaaa tctggaccct gtgcagcagc gaggcgcagg ccgaggccat gcgcaagcat      960
tacgatgacg tctgggcgcc ggcgcaatcg gaaaagtacc gggtcaaggc taactacatc     1020
gaccaactgg tggtcatcac cggcgatagc tctaccatcg aaccaccggc cggctacagc     1080
aagatcgagt acgacctcaa tgccggtgcc ggcggtgact tcatctactt gtgctatcac     1140
gaacaaacct ggcaggccga caggcctaaa gatgctgtga cggatatcag gatcattttc     1200
aacaaggagc ctaccccacc tggctatacc aagctgcccc aggacctgaa caagggcgcg     1260
ggcggtgatg atgtattcct ctgctacaag accgaggctt acaacaccga caccgcaatc     1320
aacaagatca cggtcatcag cggcaacaat ccggatatca acgctcccta tggttatctg     1380
aaggtccccg gtgacctgaa caaaggtgct aaaggcaact tcatctatgc ctgtaccttc     1440
gtaggcaag                                                             1449

<210>  60
<211>  1449
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  60
atggaaaaca tagacttgcc acaaggactt gtaaactttt ccacgcaaca cctgcaactt       60
attcgtttta aagcaggttt gaatgaaacc gtactacctg gcgtcgaagc cattggactt      120
ggctataacc cattcatcag ttatgccagt gtcaacagcg gcgcggtgca attgttcgac      180
tgggccacgg ccaagaaacg cgaagtgcct ttcaaagccg gctacttcgt acccgagatc      240
gtcgacgtgc aacagaacga cagcgcaacc tacaccaacg tcagcggcaa cacgatcagc      300
gagtaccagc gcagtctggc taccagcgtc gccatcgaag gccgttacaa cttcttcagt      360
ggctcgctgt ccacggattt cgacagtaat tcactgcgca acgcggaaaa cgagttcact      420
cgcattcagc aatcgatcaa cctctggtcg ttgcgcttgc cttcggtgaa gtcattgcgc      480
gaactgatgc tgccacacat gcgccaacaa ctagatgaat tgaacgtcaa cgacccgaag      540
gccataagcc gctatttcga tagagttggc agccatttcc ttaccggcat cgtaatgggt      600
ggacgggcca tcctcgcctc ctcgaccaac aagctcaggg tcaagcgtga ctactcggtg      660
tcggtggtcg ccaaggcgag ctacgaaggg cttaccggcc agttgagcgc agaagccaaa      720
gccaagtatg gcgagtcgat cagcagcttc actcagtact ccaataccca ccaggaagtg      780
cgcggcggcg acggtgccaa ggcacatggg gtgttcagcg gcaaaaaaga agatttccag      840
gcctgggtag acagtgtgag cgcctcgccg gacttcgtcg atttcgtccc caccatcccc      900
atgcaggaaa tctggaccct gtgcagcagc gaggcgcagg ccgaggccat gaaacgtcat      960
ttcgataccg tctgggcgcg tgagcaatct gacaagtacc gtatcaaggc taactacatc     1020
gaccaactgg tggtcatcac cggcgatagc tctaccatcg aaccaccggc cggctacacc     1080
aagatcccgt acgacctgaa tgccggtgcc aaaggtgact tcatctacct gtgctatcac     1140
gaacaagcct ggtaccctga caacactaaa cctgctgtga cggctatcaa gatcatttac     1200
gaccgtgagc ctgtcccacc tggctatacc aagctgcccc aggacctgaa caagggcgcg     1260
ggcggtgatg atgtattcct ctgctacaag accgaggctt acaacaccga caccgcaatc     1320
aacaaggtca cggtcatcgg cggcaacaat gcggatatca acgctcccta tggttatctg     1380
aaggtccccg gtgacctcaa cagaggtgct ggcggcaact tcatctatgc ctgtaccttc     1440
gtaggcaag                                                             1449

<210>  61
<211>  1452
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  61
atggaacacg tagacctgcc aacgggtctg gtaaaatttt cctctaatca ccacctgcaa       60
ctgctgcgtg atacggcaga tctgagcgaa tccgtactgc ctggcgtcga agccattggt      120
ctgggctata acccattcct gggttatgcc ggtgtcggca gcggcacggt gcaactgttc      180
gactgggcca cggccaagaa acgcgaagtg cctttcaaag ccggctactt cgtacccgag      240
atcgtcgacg tgcaacagaa cgacagcgca tcctacacca acatcagcgg caacacggtc      300
accgagtacc agcgcagtct ggctaccagc gtcgccatcg aaggccgtta caacttcttc      360
agtggctcgc tgtccacgga tttcgacagt aattcactgc gcaacgcgga aaacgagttc      420
actcgcattc agcaatcgat caacctctgg tcgttgcgct tgccttcggt gaagtcattg      480
cgcgaactga tgctgccaca catgcgccaa caactagatg aattgaacgt caacgacccg      540
aaggccataa gccgctattt cgatagagtt ggcagccatt tccttaccgg catcgtaatg      600
ggtggacggg ccatcctcgc ctcctcgacc aacaagctca gggtcaagcg tgactactct      660
gtgtctgtga tcgccaaggc gagctacgaa ggtctgaccg gccagctgag cgcagaagcc      720
cgtaccaagt atggcgagtc tatgagcagc ttcactcagt actccaatac ccaccaggaa      780
gtgcgcggcg gcgacggtac caaggcacat ggggtgttca gcggcaaaaa agaagatttc      840
caggcctggg tagacagtgt gagcgcctcg ccggacttcg tcgatttcgt ccctaccatc      900
cctatgctgg aaatctggtc cctgtgcagc agcgaggcgc aggccgaggc catgcgcaag      960
cattacgatg acgtctgggc gccggcgcaa tcggaaaagt accgggtcaa ggctaactac     1020
atcgaccaac tggtggtcat caccggcgat agctctacca tcgaaccacc ggccggctac     1080
accaagatcc cgtacgacct gaatgccggt gccaaaggtg acttcatcta cctgtgctat     1140
cacgaacaag cctggtaccc tgacaacact aaacctgctg tgatggctat caagatcatt     1200
tacgaccgtg agcctgtccc aactggctat atcaagctgc ctcaggacct gaacaagggc     1260
gcgggcggtg atgatgtatt cctctgctac aagaccgagg cttacaacac cgacaccgca     1320
atcaacaagg tcacggtcat cggcggcaac aatgcggata tcaacgctcc ctatggttat     1380
ctgaaggtcc ccggtgacct caacagaggt gctggcggca acttcatcta tgcctgtacc     1440
ttcgtaggca ag                                                         1452

<210>  62
<211>  1446
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  62
atggaaaaca tagacttgcc acaaggactt gtaaactttt ccacgcaaca cctgcaactt       60
attcgtttta aagcaggttt gaatgaaacc gtactacctg gcgtcgaagc cattggactt      120
ggctataacc cattcatcag ttatgccagt gtcaacagcg gcgcggtgca attgttcgac      180
tgggccacgg ccaagaaacg cgaagtgcct ttcaaagccg gctacttcgt acccgagatc      240
gtcgacgtgc aacagaacga cagcgcatcc tacaccaaca tcagcggcaa cacgatcagc      300
gagtaccagc gcagtctggc tgtcagcgtc gccatcgaag gcaaatacaa cttcttcagc      360
ggctctctgt ccacggatta cgacgaaaat tctctgcgca acgcggaaaa cgagttcact      420
cgcattcagc aatctatcaa cctgtggtct ctgcgcctgc cttctgtgaa gtctctgcgc      480
gacctgatgc tgccacacat gcgcgaacaa ctggatgaac tggacgtcaa aaacccgagc      540
gccatcagcc gctttttcga tcgtgttggc agccatttcc tgaccggcat cgtaatgggt      600
ggtcgtgcca tcctggccgc ctctaccaac aagctgaagg tcaagcgtga ctactctgtg      660
tctgtgatcg ccaaggcgag ctacgaaggt ctgaccggcc agctgagcgc agaagcccgt      720
accaagtatg gcgagtctat gagcagcttc actcagtact ccagcaccca ccaggaagtg      780
cgcggcggcg acggtaccaa ggcacatggt gtgttcgaag gcaaagcagg tttccaggcc      840
tgggtagaca gcgtgggcac ctctccggac ttcgtcgatt tcgtccccac catccccatg      900
caggaaatct ggaccctgtg cagcagcgag gcgcaggccg aggccatgcg caagcattac      960
gatgacgtct gggcgccggc gcaatcggaa aagtaccggg tcaaggctaa ctacatcgac     1020
caactggtgg tcatcaccgg cggtagttca accatcgaac caccggtcgg ctacagcaag     1080
atcgagtacg acctcaatgc cggtgccggc ggtgacttca tctacttgtg ctatcacgaa     1140
caagcctggt accctgacaa cactaaacct gctgtgacgg ctatcaagat catttacgac     1200
cgtgagcctg tcccaactgg ctatatcaag ctgcctcagg acctgaacaa gggcgcgggc     1260
ggtgctgata tctacctgtg ctacaagctg gagggttaca acaccgacac cgcaatcaac     1320
aagatcacgg tcatcagcgg caacaatccg gatatcaacg ctccttatgg ttatgagaag     1380
gtccctggtg acctgaacaa aggtgctaaa ggcaacttca tctatgcctg taccttcgta     1440
ggcaag                                                                1446

<210>  63
<211>  1449
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  63
atggaacacg tagacctgcc aacgggtctg gtaaaatttt cctctaatca ccacctgcaa       60
ctgctgcgtg atacggcaga tctgagcgaa tccgtactgc ctggcgtcga agccattggt      120
ctgggctata acccattcct gggttatgcc ggtgtcggca gcggcacggt gcaactgttc      180
gactggaaca acgccaagaa aaaaaaagtg tctttcaaac ctgaattcgt cgtacctgag      240
atcgtcgacg tgcaacagaa cgacagcgca tcctacacca acgtcagcgg caacacggtc      300
accgagtacc agcgcagcct ggctgtcagc gtcgccatcg aaggcaaata caacttcttc      360
agcggctctc tgtccacgga ttacgacgaa aattctctgc gcaacgcgga aaacgagttc      420
actcgcattc agcaatctat caacctgtgg tctctgcgcc tgccttctgt gaagtctctg      480
cgcgacctga tgctgccaca catgcgcgaa caactggatg aactggacgt caaaaacccg      540
agcgccatca gccgcttttt cgatcgtgtt ggcagccatt tcctgaccgg catcgtaatg      600
ggtggtcgtg ccatcctggc cgcctctacc aacaagctga aggtcaagcg tgactactct      660
gtgtctgtga tcgccaaggc gagctacgaa ggtctgaccg gccagctgag cgcagaagcc      720
cgtaccaagt atggcgagtc tatgagcagc ttcactcagt actccagcac ccaccaggaa      780
gtgcgcggcg gcgacggtac caaggcacat ggtgtgttcg aaggcaaagc aggtttccag      840
gcctgggtag acagtgtgag cgcctcgccg gacttcgtcg atttcgtccc taccatccct      900
atgctggaaa tctggtccct gtgcaaaacc gactctcagg ccgaggccat gaaacgtcat      960
ttcgataccg tctgggcgcg tgagcaatct gacaagtacc gtatcaaggc taactacatc     1020
gaccaactgg tggtcatcac cggcgatagc tctaccatcg aaccaccggt cggctacagc     1080
aagatcgagt acgacctcaa tgccggtgcc ggcggtgact tcatctactt gtgctatcac     1140
gaacaaacct ggcaggccga caggcctaaa gatgctgtga cggatatcag gatcattttc     1200
aacaaggagc ctaccccacc tggctatacc aagctgcccc aggacctgaa caagggcgcg     1260
ggcggtgatg atgtattcct ctgctacaag accgaggctt acaacaccga caccgcaatc     1320
aacaaggtca cggtcatcgg cggcaacaat gcggatatca acgctcccta tggttatctg     1380
aaggtccccg gtgacctcaa cagaggtgct ggcggcaact tcatctatgc ctgtaccttc     1440
gtaggcaag                                                             1449

<210>  64
<211>  1449
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  64
atggaaaaca tagacttgcc acaaggactt gtaaactttt ccacgcaaca cctgcaactt       60
attcgtttta aagcaggttt gaatgaaacc gtactacctg gcgtcgaagc cattggactt      120
ggctataacc cattcatcag ttatgccagt gtcaacagcg gcgcggtgca attgttcgac      180
tgggccacgg ccaagaaacg cgaagtgcct ttcaaagccg gctacttcgt acctgagatc      240
gtcgacgtgc aacagaacga cagcgcatcc tacaccaacg tcagcggcaa cacgatcagc      300
gagtaccagc gcagtctggc taccagcgtc gccatcgaag gccgttacaa cttcttcagt      360
ggctcgctgt ccacggattt cgacagtaat tcactgcgca acgcggaaaa cgagttcact      420
cgcattcagc aatcgatcaa cctctggtcg ttgcgcttgc cttcggtgaa gtcattgcgc      480
gaactgatgc tgccacacat gcgccaacaa ctagatgaat tgaacgtcaa cgacccgaag      540
gccataagcc gctatttcga tagagttggc agccatttcc ttaccggcat cgtaatgggt      600
ggacgggcca tcctcgcctc ctcgaccaac aagctcaggg tcaagcgtga ctactcggtg      660
tcggtggtcg ccaaggcgag ctacgaaggg cttaccggcc agttgagcgc agaagccaaa      720
gccaagtatg gcgagtcgat cagcagcttc actcagtact ccaataccca ccaggaagtg      780
cgcggcggcg acggtgccaa ggcacatggg gtgttcagcg gcaaaaaaga agatttccag      840
gcctgggtag acagcgtggg cacctctccg gacttcgtcg atttcgtccc caccatcccc      900
atgcaggaaa tctggaccct gtgcagcagc gaggcgcagg ccgaggccat gcgcaagcat      960
tacgatgacg tctgggcgcc ggcgcaatcg gaaaagtacc gggtcaaggc taactacatc     1020
gaccaactgg tggtcatcac cggcggtagt tcaaccatcg aaccaccggc cggctacacc     1080
aagatcccgt acgacctgaa tgccggtgcc aaaggtgact tcatctacct gtgctatcac     1140
gaacaagcct ggtaccctga caacactaaa cctgctgtga cggatatcag gatcattttc     1200
aacaaggagc ctaccccacc tggctatacc aagctgcccc aggacctgaa caagggcgcg     1260
ggcggtgatg atgtattcct ctgctacaag accgaggctt acaacaccga caccgcaatc     1320
aacaaggtca cggtcatcgg cggcaacaat gcggatatca acgctcccta tggttatctg     1380
aaggtccccg gtgacctcaa cagaggtgct ggcggcaact tcatctatgc ctgtaccttc     1440
gtaggcaag                                                             1449

<210>  65
<211>  1449
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  65
atggaacacg tagacctgcc aacgggtctg gtaaaatttt cctctaatca ccacctgcaa       60
ctgctgcgtg atacggcaga tctgagcgaa tccgtactgc ctggcgtcga agccattggt      120
ctgggctata acccattcct gggttatgcc ggtgtcggca gcggcacggt gcaactgttc      180
gactggaaca acgccaagaa aaaaaaagtg tctttcaaac ctgaattcgt cgtacctgag      240
atcgtcgacg tgcaacagaa cgacagcgca tcctacacca acatcagcgg caacacggtc      300
accgagtacc agcgcagtct ggctaccagc gtcgccatcg aaggccgtta caacttcttc      360
agtggctcgc tgtccacgga ttacgacgaa aattctctgc gcaacgcgga aaacgagttc      420
actcgcattc agcaatctat caacctgtgg tctctgcgcc tgccttctgt gaagtctctg      480
cgcgacctga tgctgccaca catgcgcgaa caactggatg aactggacgt caaaaacccg      540
agcgccatca gccgcttttt cgatcgtgtt ggcagccatt tcctgaccgg catcgtaatg      600
ggtggtcgtg ccatcctggc cgcctctacc aacaagctca gggtcaagcg tgactactcg      660
gtgtcggtgg tcgccaaggc gagctacgaa ggtctgaccg gccagctgag cgcagaagcc      720
aaagccaagt atggcgagtc gatcagcagc ttcactcagt actccaatac ccaccaggaa      780
gtgcgcggcg gcgacggtac caaggcacat ggtgtgttcg aaggcaaagc aggtttccag      840
gcctgggtag acagcgtggg cacctctccg gacttcgtcg atttcgtccc caccatcccc      900
atgcaggaaa tctggaccct gtgcagcagc gaggcgcagg ccgaggccat gcgcaagcat      960
tacgatgacg tctgggcgcc ggcgcaatcg gaaaagtacc gggtcaaggc taactacatc     1020
gaccaactgg tggtcatcac cggcgatagc tctaccatcg aaccaccggc cggctacacc     1080
aagatcccgt acgacctgaa tgccggtgcc aaaggtgact tcatctacct gtgctatcac     1140
gaacaagcct ggtaccctga caacactaaa cctgctgtga cggctatcaa gatcatttac     1200
gaccgtgagc ctgtcccaac tggctatacc aagctgcccc aggacctgaa caagggcgcg     1260
ggcggtgatg atgtattcct ctgctacaag accgaggctt acaacaccga caccgcaatc     1320
aacaagatca cggtcatcgg cggcaacaat gcggatatca acgctcccta tggttatctg     1380
aaggtccccg gtgacctcaa cagaggtgct ggcggcaact tcatctatgc ctgtaccttc     1440
gtaggcaag                                                             1449

<210>  66
<211>  1449
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  66
atggaacacg tagacctgcc aacgggtctg gtaaaatttt cctctaatca ccacctgcaa       60
ctgctgcgtg atacggcaga tctgagcgaa tccgtactgc ctggcgtcga agccattggt      120
ctgggctata acccattcct gggttatgcc ggtgtcggca gcggcacggt gcaactgttc      180
gactggaaca acgccaagaa aaaaaaagtg tctttcaaac ctgaattcgt cgtacctgag      240
atcgtcgacg tgcaacagaa cgacagcgca tcctacacca acatcagcgg caacacggtc      300
accgagtacc agcgcagcct ggctgtcagc gtcgccatcg aaggccgtta caacttcttc      360
agcggctctc tgtccacgga ttacgacgaa aattctctgc gcaacgcgga aaacgagttc      420
actcgcattc agcaatcgat caacctctgg tcgttgcgct tgccttcggt gaagtctctg      480
cgcgacctga tgctgccaca catgcgcgaa caactggatg aactggacgt caaaaacccg      540
agcgccatca gccgcttttt cgatcgtgtt ggcagccatt tcctgaccgg catcgtaatg      600
ggtggtcgtg ccatcctggc cgcctctacc aacaagctga aggtcaagcg tgactactct      660
gtgtctgtga tcgccaaggc gagctacgaa gggcttaccg gccagttgag cgcagaagcc      720
aaagccaagt atggcgagtc gatcagcagc ttcactcagt actccagcac ccaccaggaa      780
gtgcgcggcg gcgacggtac caaggcacat ggtgtgttcg aaggcaaagc aggtttccag      840
gcctgggtag acagcgtggg cacctctccg gacttcgtcg atttcgtccc taccatccct      900
atgctggaaa tctggaccct gtgcagcagc gaggcgcagg ccgaggccat gcgcaagcat      960
tacgatgacg tctgggcgcc ggcgcaatcg gaaaagtacc gggtcaaggc taactacatc     1020
gaccaactgg tggtcatcac cggcggtagt tcaaccatcg aaccaccggt cggctacagc     1080
aagatcgagt acgacctgaa tgccggtgcc aaaggtgact tcatctacct gtgctatcac     1140
gaacaaacct ggcaggccga caggcctaaa gatgctgtga cggatatcag gatcattttc     1200
aacaaggagc ctaccccacc tggctatacc aagctgcccc aggacctgaa caagggcgcg     1260
ggcggtgatg atgtattcct ctgctacaag accgaggctt acaacaccga caccgcaatc     1320
aacaaggtca cggtcatcgg cggcaacaat gcggatatca acgctcccta tggttatctg     1380
aaggtccccg gtgacctcaa cagaggtgct ggcggcaact tcatctatgc ctgtaccttc     1440
gtaggcaag                                                             1449

<210>  67
<211>  1449
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  67
atggaaaaca tagacttgcc acaaggactt gtaaactttt ccacgcaaca cctgcaactt       60
attcgtttta aagcaggttt gaatgaaacc gtactacctg gcgtcgaagc cattggactt      120
ggctataacc cattcatcag ttatgccagt gtcaacagcg gcgcggtgca attgttcgac      180
tgggccacgg ccaagaaacg cgaagtgcct ttcaaagccg gctacttcgt acccgagatc      240
gtcgacgtgc aacagaacga cagcgcaacc tacaccaacg tcagcggcaa cacgatcagc      300
gagtaccagc gcagtctggc taccagcgtc gccatcgaag gccgttacaa cttcttcagt      360
ggctcgctgt ccacggattt cgacagtaat tcactgcgca acgcggaaaa cgagttcact      420
cgcattcagc aatctatcaa cctgtggtct ctgcgcctgc cttcggtgaa gtcattgcgc      480
gaactgatgc tgccacacat gcgccaacaa ctagatgaat tgaacgtcaa cgacccgaag      540
gccataagcc gctatttcga tagagttggc agccatttcc tgaccggcat cgtaatgggt      600
ggtcgtgcca tcctgaccgc ctctaccaac aagctgaagg tcaagcgtga ctactctgtg      660
tcggtggtcg ccaaggcgag ctacgaaggg cttaccggcc agttgagcgc agaagccaaa      720
gccaagtatg gcgagtcgat cagcagcttc actcagtact ccagcaccca ccaggaagtg      780
cgcggcggcg acggtaccaa ggcacatggt gtgttcagcg gcaaaaaaga agatttccag      840
gcctgggtag acagcgtggg cacctctccg gacttcgtcg atttcgtccc caccatcccc      900
atgcaggaaa tctggtccct gtgcaaaacc gactctcagg ccgaggccat gaaacgtcat      960
ttcgataccg tctgggcgcg tgagcaatct gacaagtacc gtatcaaggc taactacatc     1020
gaccaactgg tggtcatcac cggcggtagt tcaaccatcg aaccaccggt cggctacagc     1080
aagatcgagt acgacctcaa tgccggtgcc ggcggtgact tcatctacct gtgctatcac     1140
gaacaaacct ggcaggccga caggcctaaa gatgctgtga cggatatcag gatcattttc     1200
aacaaggagc ctaccccacc tggctatacc aagctgcccc aggacctgaa caagggcgcg     1260
ggcggtgatg atgtattcct ctgctacaag accgaggctt acaacaccga caccgcaatc     1320
aacaaggtca cggtcatcgg cggcaacaat gcggatatca acgctcccta tggttatctg     1380
aaggtccccg gtgacctcaa cagaggtgct ggcggcaact tcatctatgc ctgtaccttc     1440
gtaggcaag                                                             1449

<210>  68
<211>  1452
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  68
atggaacacg tagacctgcc aacgggtctg gtaaaatttt cctctaatca ccacctgcaa       60
ctgctgcgtg atacggcaga tctgagcgaa tccgtactgc ctggcgtcga agccattggt      120
ctgggctata acccattcct gggttatgcc ggtgtcggca gcggcacggt gcaactgttc      180
gactggaaca acgccaagaa aaaaaaagtg tctttcaaac ctgaattcgt cgtacctgag      240
atcgtcgacg tgcaacagaa cgacagcgca tcctacacca acatcagcgg caacacggtc      300
accgagtacc agcgcagcct ggctgtcagc gtcgccatcg aaggccgtta caacttcttc      360
agtggctcgc tgtccacgga tttcgacagt aattcactgc gcaacgcgga aaacgagttc      420
actcgcattc agcaatcgat caacctctgg tcgttgcgct tgccttcggt gaagtcattg      480
cgcgaactga tgctgccaca catgcgccaa caactagatg aattgaacgt caacgacccg      540
aaggccataa gccgctattt cgatagagtt ggcagccatt tccttaccgg catcgtaatg      600
ggtggacggg ccatcctcgc ctcctcgacc aacaagctca gggtcaagcg tgactactcg      660
gtgtcggtgg tcgccaaggc gagctacgaa gggcttaccg gccagttgag cgcagaagcc      720
aaagccaagt atggcgagtc gatcagcagc ttcactcagt actccaatac ccaccaggaa      780
gtgcgcggcg gcgacggtgc caaggcacat ggggtgttca gcggcaaaaa agaagatttc      840
caggcctggg tagacagtgt gagcgcctcg ccggacttcg tcgatttcgt ccccaccatc      900
cctatgctgg aaatctggac cctgtgcaaa accgactctc aggccgaggc catgaaacgt      960
catttcgata ccgtctgggc gccggcgcaa tcggaaaagt accgggtcaa ggctaactac     1020
atcgaccaac tggtggtcat caccggcggt agttcaacca tcgaaccacc ggtcggctac     1080
accaagatcc cgtacgacct gaatgccggt gccaaaggtg acttcatcta cctgtgctat     1140
cacgaacaag cctggtaccc tgacaacact aaacctgctg tgacggctat caagatcatt     1200
tacgaccgtg agcctgtccc aactggctat atcaagctgc ctcaggacct gaacaagggc     1260
gcgggcggtg ctgatatcta cctgtgctac aagctggagg gttacaacac cgacaccgca     1320
atcaacaaga tcacggtcat cggcggcaac aatgcggata tcaacgctcc ctatggttat     1380
ctgaaggtcc ccggtgacct caacagaggt gctggcggca acttcatcta tgcctgtacc     1440
ttcgtaggca ag                                                         1452

<210>  69
<211>  1452
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  69
atggaacacg tagacctgcc aacgggtctg gtaaaatttt cctctaatca ccacctgcaa       60
ctgctgcgtg atacggcaga tctgagcgaa tccgtactgc ctggcgtcga agccattggt      120
ctgggctata acccattcct gggttatgcc ggtgtcggca gcggcacggt gcaactgttc      180
gactggaaca acgccaagaa aaaaaaagtg tctttcaaac ctgaattcgt cgtacctgag      240
atcgtcgacg tgcaacagaa cgacagcgca acctacacca acgtcagcgg caacacgatc      300
agcgagtacc agcgcagtct ggctgtcagc gtcgccatcg aaggcaaata caacttcttc      360
agcggctctc tgtccacgga ttacgacgaa aattctctgc gcaacgcgga aaacgagttc      420
actcgcattc agcaatctat caacctgtgg tctctgcgcc tgccttctgt gaagtctctg      480
cgcgacctga tgctgccaca catgcgcgaa caactggatg aactggacgt caaaaacccg      540
agcgccatca gccgcttttt cgatcgtgtt ggcagccatt tccttaccgg catcgtaatg      600
ggtggtcgtg ccatcctggc cgcctctacc aacaagctca gggtcaagcg tgactactcg      660
gtgtcggtgg tcgccaaggc gagctacgaa gggcttaccg gccagttgag cgcagaagcc      720
aaagccaagt atggcgagtc gatcagcagc ttcactcagt actccaatac ccaccaggaa      780
gtgcgcggcg gcgacggtgc caaggcacat ggggtgttca gcggcaaaaa agaagatttc      840
caggcctggg tagacagtgt gagcgcctcg ccggacttcg tcgatttcgt ccccaccatc      900
cccatgcagg aaatctggac cctgtgcaaa accgactctc aggccgaggc catgaaacgt      960
catttcgata ccgtctgggc gcgtgagcaa tctgacaagt accgtatcaa ggctaactac     1020
atcgaccaac tggtggtcat caccggcggt agttcgacca tcgaaccacc ggtcggctac     1080
agcaagatcg agtacgacct caatgccggt gccggcggtg acttcatcta cttgtgctat     1140
cacgaacaag cctggtaccc tgacaacact aaacctgctg tgacggatat caggatcatt     1200
ttcaacaagg agcctacccc acctggctat accaagctgc cccaggacct gaacaagggc     1260
gcgggcggtg atgatgtatt cctctgctac aagaccgagg cttacaacac cgacaccgca     1320
atcaacaagg tcacggtcat cggcggcaac aatccggata tcaacgctcc ctatggttat     1380
ctgaaggtcc ccggtgacct caacagaggt gctggcggca acttcatcta tgcctgtacc     1440
ttcgtaggca ag                                                         1452

<210>  70
<211>  1446
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  70
atggaaaaca tagacttgcc acaaggactt gtaaactttt ccacgcaaca cctgcaactt       60
attcgtttta aagcaggttt gaatgaaacc gtactacctg gcgtcgaagc cattggactt      120
ggctataacc cattcatcag ttatgccagt gtcaacagcg gcgcggtgca attgttcgac      180
tgggccacgg ccaagaaacg cgaagtgcct ttcaaagccg gctacttcgt acccgagatc      240
gtcgacgtgc aacagaacga cagcgcaacc tacaccaacg tcagcggcaa cacgatcagc      300
gagtaccagc gcagtctggc taccagcgtc gccatcgaag gccgttacaa cttcttcagc      360
ggctctctgt ccacggatta cgacgaaaat tctctgcgca acgcggaaaa cgagttcact      420
cgcattcagc aatctatcaa cctgtggtct ctgcgcttgc cttcggtgaa gtcattgcgc      480
gaactgatgc tgccacacat gcgccaacaa ctagatgaat tgaacgtcaa cgacccgaag      540
gccataagcc gctatttcga tagagttggc agccatttcc ttaccggcat cgtaatgggt      600
ggacgggcca tcctcgcctc ctcgaccaac aagctcaggg tcaagcgtga ctactcggtg      660
tcggtggtcg ccaaggcgag ctacgaaggt ctgaccggcc agttgagcgc agaagccaaa      720
gccaagtatg gcgagtcgat cagcagcttc actcagtact ccaataccca ccaggaagtg      780
cgcggcggcg acggtgccaa ggcacatggt gtgttcgaag gcaaagcagg tttccaggcc      840
tgggtagaca gcgtgggcac ctctccggac ttcgtcgatt tcgtccctac catccctatg      900
ctggaaatct ggtccctgtg caaaaccgac tctcaggccg aggccatgaa acgtcatttc      960
gataccgtct gggcgcgtga gcaatctgac aagtaccgta tcaaggctaa ctacatcgac     1020
caactggtgg tcatcaccgg cgatagctct accatcgaac caccggccgg ctacaccaag     1080
atcccgtacg acctgaatgc cggtgccaaa ggtgacttca tctacctgtg ctatcacgaa     1140
caagcctggt accctgacaa cactaaacct gctgtgacgg ctatcaagat catttacgac     1200
cgtgagcctg tcccaactgg ctatatcaag ctgccccagg acctgaacaa gggcgcgggc     1260
ggtgatgatg tattcctctg ctacaagctg gagggttaca acaccgacac cgcaatcaac     1320
aagatcacgg tcatcggcgg caacaatgcg gatatcaacg ctccttatgg ttatgagaag     1380
gtccctggtg acctcaacag aggtgctggc ggcaacttca tctatgcctg taccttcgta     1440
gacaag                                                                1446

<210>  71
<211>  1449
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  71
atggaaaaca tagacttgcc acaaggactt gtaaactttt ccacgcaaca cctgcaactt       60
attcgtttta aagcaggttt gaatgaaacc gtactacctg gcgtcgaagc cattggactt      120
ggctataacc cattcatcag ttatgccagt gtcaacagcg gcgcggtgca attgttcgac      180
tgggccacgg ccaagaaacg cgaagtgcct ttcaaagccg gctacttcgt acccgagatc      240
gtcgacgtgc aacagaacga cagcgcaacc tacaccaacg tcagcggcaa cacgatcagc      300
gagtaccagc gcagtctggc taccagcgtc gccatcgaag gccgttacaa cttcttcagt      360
ggctcgctgt ccacggattt cgacagtaat tcactgcgca acgcggaaaa cgagttcact      420
cgcattcagc aatcgatcaa cctctggtcg ttgcgcttgc cttcggtgaa gtcattgcgc      480
gaactgatgc tgccacacat gcgccaacaa ctagatgaat tgaacgtcaa cgacccgaag      540
gccataagcc gctatttcga tagagttggc agccatttcc ttaccggcat cgtaatgggt      600
ggacgggcca tcctcgcctc ctcgaccaac aagctcaggg tcaagcgtga ctactctgtg      660
tctgtgatcg ccaaggcgag ctacgaaggt ctgaccggcc agctgagcgc agaagcccgt      720
accaagtatg gcgagtctat gagcagcttc actcagtact ccagcaccca ccaggaagtg      780
cgcggcggcg acggtgccaa ggcacatggg gtgttcagcg gcaaaaaaga agatttccag      840
gcctgggtag acagtgtgag cgcctcgccg gacttcgtcg atttcgtccc caccatcccc      900
atgcaggaaa tctggaccct gtgcagcagc gaggcgcagg ccgaggccat gcgcaagcat      960
tacgatgacg tctgggcgcc ggcgcaatcg gaaaagtacc gggtcaaggc taactacatc     1020
gaccaactgg tggtcatcac cggcgatagc tctaccatcg aaccaccggt cggctacagc     1080
aagatcgagt acgacctcaa tgccggtgcc ggcggtgact tcatctactt gtgctatcac     1140
gaacaaacct ggcaggccga caggcctaaa gatgctgtga cggatatcag gatcattttc     1200
aacaaggagc ctaccccacc tggctatacc aagctgcctc aggacctgaa caagggcgcg     1260
ggcggtgctg atatctacct gtgctacaag ctggagggtt acaacaccga caccgcaatc     1320
aacaagatca cggtcatcag cggcaacaat gcggatatca acgctcccta tggttatctg     1380
aaggtccccg gtgacctcaa cagaggtgct ggcggcaact tcatctatgc ctgtaccttc     1440
gtaggcaag                                                             1449

<210>  72
<211>  1446
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  72
atggaaaaca tagacttgcc acaaggactt gtaaactttt ccacgcaaca cctgcaactt       60
attcgtttta aagcaggttt gaatgaaacc gtactacctg gcgtcgaagc cattggactt      120
ggctataacc cattcatcag ttatgccagt gtcaacagcg gcgcggtgca attgttcgac      180
tgggccacgg ccaagaaacg cgaagtgcct ttcaaagccg gctacttcgt acccgagatc      240
gtcgacgtgc aacagaacga cagcgcatcc tacaccaacg tcagcggcaa cacgatcagc      300
gagtaccagc gcagtctggc taccagcgtc gccatcgaag gccgttacaa cttcttcagt      360
ggctcgctgt ccacggattt cgacagtaat tcactgcgca acgcggaaaa cgagttcact      420
cgcattcagc aatctatcaa cctgtggtct ctgcgcctgc cttctgtgaa gtctctgcgc      480
gacctgatgc tgccacacat gcgccaacaa ctagatgaat tgaacgtcaa cgacccgaag      540
gccataagcc gctatttcga tagagttggc agccatttcc ttaccggcat cgtaatgggt      600
ggacgggcca tcctcgcctc ctcgaccaac aagctcaggg tcaagcgtga ctactcggtg      660
tctgtgatcg ccaaggcgag ctacgaaggt ctgaccggcc agctgagcgc agaagcccgt      720
accaagtatg gcgagtctat gagcagcttc actcagtact ccagcaccca ccaggaagtg      780
cgcggcggcg acggtaccaa ggcacatggt gtgttcgaag gcaaagcagg tttccaggcc      840
tgggtagaca gtgtgggcac ctctccggac ttcgtcgatt tcgtccctac catccctatg      900
ctggaaatct ggaccctgtg cagcagcgag gcgcaggccg aggccatgcg caagcattac      960
gatgacgtct gggcgccggc gcaatcggaa aagtaccggg tcaaggctaa ctgcatcgac     1020
caactggtgg tcatcaccgg cgatagctct accatcgaac caccggtcgg ctacagcaag     1080
atcgagtacg acctcaatgc cggtgccggc ggtgacttca tctacttgtg ctatcacgaa     1140
caaacctggc aggccgacag gcctaaagat gctgtgacgg atatcaggat cattttcaac     1200
aaggagccta ccccacctgg ctataccaag ctgccccagg acctgaacaa gggcgcgggc     1260
ggtgatgatg tattcctctg ctacaagacc gaggcttaca acaccgacac cgcaatcaac     1320
aaggtcacgg tcatcggcgg caacaatgcg gatatcaacg ctccctatgg ttatctgaag     1380
gtccccggtg acctcaacag aggtgctggc ggcaacttca tctatgcctg taccttcgta     1440
ggcaag                                                                1446

<210>  73
<211>  1449
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  73
atggaacacg tagacctgcc aacgggtctg gtaaaatttt cctctaatca ccacctgcaa       60
ctgctgcgtg atacggcaga tctgagcgaa tccgtactgc ctggcgtcga agccattggt      120
ctgggctata acccattcct gggttatgcc ggtgtcggca gcggcacggt gcaactgttc      180
gactggaaca acgccaagaa aaaaaaagtg tctttcaaac ctgaattcgt cgtacctgag      240
atcgtcgacg tgcaacagaa cgacagcgca tcctacacca acatcagcgg caacacggtc      300
accgagtacc agcgcagcct ggctgtcagc gtcgccatcg aaggccgtta caacttcttc      360
agcggctctc tgtccacgga ttacgacgaa aattctctgc gcaacgcgga aaacgagttc      420
actcgcattc agcaatctat caacctgtgg tctctgcgcc tgccttctgt gaagtctctg      480
cgcgacctga tgctgccaca catgcgcgaa caactggatg aactggacgt caaaaacccg      540
agcgccatca gccgcttttt cgatcgtgtt ggcagccatt tccttaccgg catcgtaatg      600
ggtggacgtg ccatcctggc cgcctctacc aacaagctga aggtcaagcg tgactactcg      660
gtgtcggtgg tcgccaaggc gagctacgaa gggcttaccg gccagttgag cgcagaagcc      720
aaagccaagt atggcgagtc gatcagcagc ttcactcagt actccaatac ccaccaggaa      780
gtgcgcggcg gcgacggtgc caaggcacat ggtgtgttcg aaggcaaagc aggtttccag      840
gcctgggtag acagtgtgag cgcctcgccg gacttcgtcg atttcgtccc taccatccct      900
atgctggaaa tctggtccct gtgcaaaacc gactctcggg ccgaggccat gaaacgtcat      960
ttcgataccg tctgggcgcg tgagcaatct gacaagtacc gtatcaaggc taactacatc     1020
gaccaactgg tggtcatcac cggcggtagt tcaaccatcg aaccaccggt cggctacagc     1080
aagatcgagt acgacctcaa tgccggtgcc ggcggtgact tcatctactt gtgctatcac     1140
gaacaaacct ggtaccctga caacactaaa cctgctgtga cggctatcaa gatcatttac     1200
gaccgtgagc ctgtcccaac tggctatacc aagctgcccc aggacctgaa caagggcgcg     1260
ggcggtgatg atgtattcct ctgctacaag accgaggctt acaacaccga caccgcaatc     1320
aacaaggtca cggtcatcgg cggcaacaat ccggatatca acgctcctta tggttatgag     1380
aaggtccctg gtgacctgaa caaaggtgct aaaggcaact tcatctatgc ctgtaccttc     1440
gtaggcaag                                                             1449

<210>  74
<211>  1449
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  74
atggaaaaca tagacttgcc acaaggactt gtaaactttt ccacgcaaca cctgcaactt       60
attcgtttta aagcaggttt gaatgaaacc gtactacctg gcgtcgaagc cattggactt      120
ggctataacc cattcatcag ttatgccagt gtcaacagcg gcgcggtgca attgttcgac      180
tgggccacgg ccaagaaacg cgaagtgcct ttcaaagccg gctacttcgt acccgagatc      240
gtcgacgtgc aacagaacga cagcgcaacc tacaccaacg tcagcggcaa cacgatcagc      300
gagtaccagc gcagtctggc taccagcgtc gccatcgaag gccgttacaa cttcttcagt      360
ggctcgctgt ccacggatta cgacgaaaat tctctgcgca acgcggaaaa cgagttcact      420
cgcattcagc aatctatcaa cctgtggtct ctgcgcctgc cttctgtgaa gtctctgcgc      480
gacctgatgc tgccacacat gcgcgaacaa ctagatgaat tgaacgtcaa cgacccgaag      540
gccataagcc gctatttcga tagagttggc agccatttcc ttaccggcat cgtaatgggt      600
ggacgggcca tcctcgcctc ctcgaccaac aagctcaggg tcaagcgtga ctactcggtg      660
tcggtggtcg ccaaggcgag ctacgaaggg cttaccggcc agttgagcgc agaagccaaa      720
gccaagtatg gcgagtcgat cagcagcttc actcagtact ccaataccca ccaggaagtg      780
cgcggcggcg acggtgccaa ggcacatggg gtgttcagcg gcaaaaaaga agatttccag      840
gcctgggtag acagtgtgag cgcctcgccg gacttcgtcg atttcgtccc caccatcccc      900
atgcaggaaa tctggaccct gtgcagcagc gaggcgcagg ccgaggccat gcgcaagcat      960
tacgatgacg tctgggcgcc ggcgcaatcg gaaaagtacc gggtcaaggc taactacatc     1020
gaccaactgg tggtcatcac cggcggtagt tcaaccatcg aaccaccggt cggctacagc     1080
aagatcgagt acgacctcaa tgccggtgcc ggcggtgact tcatctactt gtgctatcac     1140
gaacaaacct ggcaggccga caggcctaaa gatgctgtga cggctatcaa gatcatttac     1200
gaccgtgagc ctgtcccaac tggctatatc aagctgcctc aggacctgaa caagggcgcg     1260
ggcggtgctg atatctacct gtgctacaag ctggagggtt acaacaccga caccgcaatc     1320
aacaagatca cggtcatcag cggcaacaat ccggatatca acgctcctta tggttatgag     1380
aaggtccctg gtgacctgaa caaaggtgct aaaggcaact tcatctatgc ctgtaccttc     1440
gtaggcaag                                                             1449

<210>  75
<211>  1446
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  75
atggaaaaca tagacttgcc acaaggactt gtaaactttt ccacgcaaca cctgcaactt       60
attcgtttta aagcaggttt gaatgaaacc gtactacctg gcgtcgaagc cattggactt      120
ggctataacc cattcatcag ttatgccagt gtcaacagcg gcgcggtgca attgttcgac      180
tgggccacgg ccaagaaacg cgaagtgcct ttcaaagccg gctacttcgt acccgagatc      240
gtcgacgtgc aacagaacga cagcgcaacc tacaccaacg tcagcggcaa cacgatcagc      300
gagtaccagc gcagtctggc taccagcgtc gccatcgaag gccgttacaa cttcttcagc      360
ggctctctgt ccacggatta cgacgaaaat tctctgcgca acgcggaaaa cgagttcact      420
cgcattcagc aatctatcaa cctgtggtct ctgcgcctgc cttctgtgaa gtctctgcgc      480
gacctgatgc tgccacacat gcgccaacaa ctagatgaat tgaacgtcaa cgacccgaag      540
gccataagcc gctatttcga tcgtgttggc agccatttcc tgaccggcat cgtaatgggt      600
ggtcgtgcca tcctggccgc ctctaccaac aagctgaagg tcaagcgtga ctactctgtg      660
tctgtgatcg ccaaggcgag ctacgaaggt ctgaccggcc agctgagcgc agaagcccgt      720
accaagtatg gcgagtctat gagcagcttc actcagtact ccaataccca ccaggaagtg      780
cgcggcggcg acggtaccaa ggcacatggt gtgttcgaag gcaaagcagg tttccaggcc      840
tgggtagaca gtgtgagcgc ctcgccggac ttcgtcgatt tcgtccccac catccccatg      900
caggaaatct ggaccctgtg cagcagcgag gcgcaggccg aggccatgcg caagcattac      960
gatgacgtct gggcgccggc gcaatcggaa aagtaccggg tcaaggctaa ctacatcgac     1020
caactggtgg tcatcaccgg cggtagttca accatcgaac caccggtcgg ctacagcaag     1080
atcgagtacg acctcaatgc cggtgccggc ggtgacttca tctacttgtg ctatcacgaa     1140
caaacctggc aggccgacag gcctaaagat gctgtgacgg atatcaggat cattttcaac     1200
aaggagccta ccccacctgg ctataccaag ctgccccagg acctgaacaa gggcgcgggc     1260
ggtgatgatg tattcctctg ctacaagacc gaggcttaca acaccgacac cgcaatcaac     1320
aaggtcacgg tcatcggcgg caacaatgcg gatatcaacg ctccttatgg ttatgagaag     1380
gtccctggtg acctgaacaa aggtgctaaa ggcaacttca tctatgcctg taccttcgta     1440
ggcaag                                                                1446

<210>  76
<211>  1449
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  76
atggaacacg tagacctgcc aacgggtctg gtaaaatttt cctctaatca ccacctgcaa       60
ctgctgcgtg atacggcaga tctgagcgaa tccgtactgc ctggcgtcga agccattgga      120
cttggctata acccattcat cagttatgcc agtgtcaaca gcggcgcggt gcaattgttc      180
gactgggcca cggccaagaa acgcgaagtg cctttcaaag ccggctactt cgtacccgag      240
atcgtcgacg tgcaacagaa cgacagcgca acctacacca acgtcagcgg caacacggtc      300
accgagtacc agcgcagcct ggctgtcagc gtcgccatcg aaggccgtta caacttcttc      360
agtggctcgc tgtccacgga tttcgacagt aattcactgc gcaacgcgga aaacgagttc      420
actcgcattc agcaatcgat caacctctgg tcgttgcgct tgccttcggt gaagtcattg      480
cgcgaactga tgctgccaca catgcgcgaa caactagatg aactggacgt caaaaacccg      540
agcgccatca gccgcttttt cgatcgtgtt ggcagccatt tccttaccgg catcgtaatg      600
ggtggacggg ccatcctcgc ctcctcgacc aacaagctca gggtcaagcg tgactactct      660
gtgtctgtga tcgccaaggc gagctacgaa ggtctgaccg gccagctgag cgcagaagcc      720
cgtaccaagt atggcgagtc tatgagcagc ttcactcagt actccagcac ccaccaggaa      780
gtgcgcggcg gcgacggtac caaggcacat ggtgtgttcg aaggcaaagc aggtttccag      840
gcctgggtag acagcgtggg cacctctccg gacttcgtcg atttcgtccc taccatccct      900
atgctggaaa tctggtccct gtgcaaaacc gactctcagg ccgaggccat gaaacgtcat      960
ttcgataccg tctgggcgcg tgagcaatct gacaagtacc gtatcaaggc taactacatc     1020
gaccaactgg tggtcatcac cggcgatagc tctaccatcg aaccaccggc cggctacacc     1080
aagatcccgt acgacctgaa tgccggtgcc aaaggtgact tcatctacct gtgctatcac     1140
gaacaagcct ggtaccctga caacactaaa cctgctgtga cggctatcaa gatcatttac     1200
gaccgtgagc ctgtcccaac tggctatatc aagctgcctc aggacctgaa caagggcgcg     1260
ggcggtgatg atgtattcct ctgctacaag accgaggctt acaacaccga caccgcaatc     1320
aacaaggtca cggtcatcag cggcaacaat ccggatatca acgctcctta tggttatgag     1380
aaggtccctg gtgacctgaa caaaggtgct aaaggcaact tcatctatgc ctgtaccttc     1440
gtaggcaag                                                             1449

<210>  77
<211>  1449
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  77
atggaaaaca tagacttgcc acaaggactt gtaaactttt ccacgcaaca cctgcaactt       60
attcgtttta aagcaggttt gaatgaaacc gtactacctg gcgtcgaagc cattggactt      120
ggctataacc cattcatcag ttatgccagt gtcaacagcg gcgcggtgca attgttcgac      180
tgggccacgg ccaagaaacg cgaagtgcct ttcaaagccg gctacttcgt acccgagatc      240
gtcgacgtgc aacagaacga cagcgcaacc tacaccaacg tcagcggcaa cacgatcagc      300
gagtaccagc gcagtctggc taccagcgtc gccatcgaag gccgttacaa cttcttcagc      360
ggctctctgt ccacggatta cgacgaaaat tctctgcgca acgcggaaaa cgagttcact      420
cgcattcagc aatctatcaa cctgtggtct ctgcgcctgc cttctgtgaa gtctctgcgc      480
gacctgatgc tgccacacat gcgcgaacaa ctggatgaac tggacgtcaa aaacccgagc      540
gccatcagcc gctttttcga tcgtgttggc agccatttcc tgaccggcat cgtaatgggt      600
ggtcgtgcca tcctggccgc ctctaccaac aagctgaagg tcaagcgtga ctactcggtg      660
tcggtggtcg ccaaggcgag ctacgaaggg cttaccggcc agttgagcgc agaagccaaa      720
gccaagtatg gcgagtcgat cagcagcttc actcagtact ccaataccca ccaggaagtg      780
cgcggcggcg acggtgccaa ggcacatggg gtgttcagcg gcaaaaaaga agatttccag      840
gcctgggtag acagtgtgag cgcctcgccg gacttcgtcg atttcgtccc caccatcccc      900
atgcaggaaa tctggtccct gtgcaaaacc gactctcagg ccgaggccat gaaacgtcat      960
ttcgataccg tctgggcgcg tgagcaatct gacaagtacc gtatcaaggc taactacatc     1020
gaccaactgg tggtcatcac cggcgatagc tctaccatcg aaccaccggc cggctacacc     1080
aagatcccgt acgacctcaa tgccggtgcc ggcggtgact tcatctactt gtgctatcac     1140
gaacaaacct ggcaggccga caggcctaaa gatgctgtga cggatatcag gatcattttc     1200
aacaaggagc ctaccccacc tggctatacc aagctgcctc aggacctgaa caagggcgcg     1260
ggcggtgatg atgtattcct ctgctacaag accgaggctt acaacaccga caccgcaatc     1320
aacaaggtca cggtcatcgg cggcaacaat gcggatatca acgctcccta tggttatctg     1380
aaggtccccg gtgacctcaa cagaggtgct ggcggcaact tcatctatgc ctgtaccttc     1440
gtaggcaag                                                             1449

<210>  78
<211>  1449
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  78
atggaaaaca tagacttgcc acaaggactt gtaaactttt ccacgcaaca cctgcaactt       60
attcgtttta aagcaggttt gaatgaaacc gtactacctg gcgtcgaagc cattggactt      120
ggctataacc cattcatcag ttatgccggt gtcggcagcg gcacggtgca attgttcgac      180
tgggccacgg ccaagaaacg cgaagtgcct ttcaaagccg gctacttcgt acccgagatc      240
gtcgacgtgc aacagaacga cagcgcaacc tacaccaacg tcagcggcaa cacgatcacc      300
gagtaccagc gcagtctggc taccagcgtc gccatcgaag gccgttacaa cttcttcagt      360
ggctcgctgt ccacggattt cgacagtaat tcactgcgca acgcggaaaa cgagttcgct      420
cgcattcagc aatcgatcaa cctctggtcg ttgcgcttgc cttcggtgaa gtcattgcgc      480
gaactgatgc tgccacacat gcgcgaacaa ctggatgaac tggacgtcaa aaacccgagc      540
gccatcagcc gctttttcga tcgtgttggc agccatttcc tgaccggcat cgtaatgggt      600
ggacgggcca tcctcgcctc ctcgaccaac aagctcaggg tcaagcgtga ctactcggtg      660
tcggtggtcg ccaaggcgag ctacgaaggt ctgaccggcc agctgagcgc agaagcccgt      720
accaagtatg gcgagtctat gagcagcttc actcagtact ccaataccca ccaggaagtg      780
cgcggcggcg acggtgccaa ggcacatggg gtgttcagcg gcaaaaaaga agatttccag      840
gcctgggtag acagtgtgag cgcctcgccg gacttcgtcg atttcgtccc caccatcccc      900
atgcaggaaa tctggaccct gtgcagcagc gaggcgcagg ccgaggccat gcgcaagcat      960
tacgatgacg tctgggcgcc ggcgcaatcg gaaaagtacc gggtcaaggc taactacatc     1020
gaccaactgg tggtcatcac cggcgatagc tctaccatcg aaccaccggc cggctacacc     1080
aagatcccgt acgacctgaa tgccggtgcc aaaggtgact tcatctacct gtgctatcac     1140
gaacaagcct ggtaccctga caacactaaa cctgctgtga cggctatcaa gatcatttac     1200
gaccgtgagc ctgtcccaac tggctatatc aagctgcctc aggacctgaa caagggcgcg     1260
ggcggtgctg atatctacct gtgctacaag ctggagggtt acaacaccga caccgcaatc     1320
aacaaggtca cggtcatcgg cggcaacaat gcggatatca acgctcccta tggttatctg     1380
aaggtccccg gtgacctcaa cagaggtgct ggcggcaact tcatctatgc ctgtaccttc     1440
gtaggcaag                                                             1449

<210>  79
<211>  1446
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  79
atggaaaaca tagacttgcc acaaggactt gtaaactttt ccacgcaaca cctgcaactt       60
attcgtttta aagcaggttt gaatgaaacc gtactacctg gcgtcgaagc cattggactt      120
ggctataacc cattcatcag ttatgccagt gtcaacagcg gcgcggtgca attgttcgac      180
tgggccacgg ccaagaaacg cgaagtgcct ttcaaagccg gctacttcgt acccgagatc      240
gtcgacgtgc aacagaacga cagcgcaacc tacaccaacg tcagcggcaa cacgatcagc      300
gagtaccagc gcagtctggc taccagcgtc gccatcgaag gccgttacaa cttcttcagt      360
ggctcgctgt ccacggattt cgacagtaat tcactgcgca acgcggaaaa cgagttcact      420
cgcattcagc aatcgatcaa cctctggtcg ttgcgcttgc cttcggtgaa gtcattgcgc      480
gaactgatgc tgccacacat gcgccaacaa ctagatgaat tgaacgtcaa cgacccgaag      540
gccataagcc gctatttcga tagagttggc agccatttcc ttaccggcat cgtaatgggt      600
ggacgggcca tcctcgcctc ctcgaccaac aagctcaggg tcaagcgtga ctactcggtg      660
tctgtgatcg ccaaggcgag ctacgaaggt ctgaccggcc agctgagcgc agaagcccgt      720
accaagtatg gcgagtctat gagcagcttc actcagtact ccagcaccca ccaggaagtg      780
cgcggcggcg acggtaccaa ggcacatggt gtgttcgaag gcaaagcagg tttccaggcc      840
tgggtagaca gcgtgagcgc ctcgccggac ttcgtcgatt tcgtccccac catccccatg      900
caggaaatct ggaccctgtg cagcagcgag gcgcaggccg aggccatgcg caagcattac      960
gatgacgtct gggcgccggc gcaatcggaa aagtaccggg tcaaggctaa ctacatcgac     1020
caactggtgg tcatcaccgg cgatagctct accatcgaac caccggccgg ctacaccaag     1080
atcccgtacg acctgaatgc cggtgccaaa ggtgacttca tctacctgtg ctatcacgaa     1140
caagcctggt accctgacaa cactaaacct gctgtgacgg ctatcaagat catttacgac     1200
cgtgagcctg tcccaactgg ctatatcaag ctgcctcagg acctgaacaa gggcgcgggc     1260
ggtgatgatg tattcctctg ctacaagacc gaggcttaca acaccgacac cgcaatcaac     1320
aaggtcacgg tcatcggcgg caacaatgcg gatatcaacg ctccctatgg ttatctgaag     1380
gtccccggtg acctcaacag aggtgctggc ggcaacttca tctatgcctg taccttcgta     1440
ggcaag                                                                1446

<210>  80
<211>  1449
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  80
atggaacacg tagacctgcc aacgggtctg gtaaaatttt cctctaatca ccacctgcaa       60
ctgctgcgtg atacggcaga tctgagcgaa tccgtactgc ctggcgtcga agccattgga      120
cttggctata acccattcat cagttatgcc agtgtcaaca gcggcgcggt gcaattgttc      180
gactgggcca cggccaagaa acgcgaagtg cctttcaaag ccggctactt cgtacccgag      240
atcgtcgacg tgcaacagaa cgacagcgca tcctacacca acatcagcgg caacacgatc      300
agcgagtacc agcgcagtct ggctaccagc gtcgccatcg aaggccgtta caacttcttc      360
agtggctcgc tgtccacgga tttcgacagt aattcactgc gcaacgcgga aaacgagttc      420
actcgcattc agcaatcgat caacctctgg tcgttgcgct tgccttcggt gaagtcattg      480
cgcgaactga tgctgccaca catgcgccaa caactagatg aattgaacgt caacgacccg      540
aaggccataa gccgctattt cgatagagtt ggcagccatt tccttaccgg catcgtaatg      600
ggtggacggg ccatcctcgc ctcctcgacc aacaagctga aggtcaagcg tgactactcg      660
gtgtcggtgg tcgccaaggc gagctacgaa ggtctgaccg gccagctgag cgcagaagcc      720
cgtaccaagt atggcgagtc gatcagcagc ttcactcagt actccagcac ccaccaggaa      780
gtgcgcggcg gcgacggtac caaggcacat ggtgtgttcg aaggcaaagc aggtttccag      840
gcctgggtag acagcgtggg cacctctccg gacttcgtcg atttcgtccc taccatccct      900
atgctggaaa tctggtccct gtgcaaaacc gactctcagg ccgaggccat gaaacgtcat      960
ttcgataccg tctgggcgcg tgagcaatct gacaagtacc gtatcaaggc taactacatc     1020
gaccaactgg tggtcatcac cggcgatagc tctaccatcg aaccaccggc cggctacacc     1080
aagatcccgt acgacctgaa tgccggtgcc aaaggtgact tcatctacct gtgctatcac     1140
gaacaagcct ggtaccctga caacactaaa cctgctgtga cggctatcaa gatcatttac     1200
gaccgtgagt ctgtcccaac tggctatatc aagctgcctc aggacctgaa caagggcgcg     1260
ggcggtgctg atatctacct gtgctacaag ctggagggtt acaacaccga caccgcaatc     1320
aacaagatca cggtcatcag cggcaacaat ccggatatca acgctcctta tggttatctg     1380
aaggtccccg gtgacctcaa cagaggtgct ggcggcaact tcatctatgc ctgtaccttc     1440
gtaggcaag                                                             1449

<210>  81
<211>  1449
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  81
atggaacacg tagacctgcc aacgggtctg gtaaaatttt cctctaatca ccacctgcaa       60
ctgctgcgtg atacggcaga tctgagcgaa tccgtactgc ctggcgtcga agccattggt      120
ctgggctata acccattcct gggttatgcc ggtgtcggca gcggcacggt gcaactgttc      180
gactggaaca acgccaagaa aaaaaaagtg tctttcaaac ctgaattcgt cgtacccgag      240
atcgtcgacg tgcaacagaa cgacagcgca tcctacacca acatcagcgg caacacgatc      300
agcgagtacc agcgcagtct ggctaccagc gtcgccatcg aaggccgtta caacttcttc      360
agtggctcgc tgtccacgga tttcgacagt aattcactgc gcaacgcgga aaacgagttc      420
actcgcattc agcaatcgat caacctctgg tcgttgcgct tgccttcggt gaagtcattg      480
cgcgaactga tgctgccaca catgcgccaa caactagatg aattgaacgt caacgacccg      540
aaggccataa gccgctattt cgatagagtt ggcagccatt tccttaccgg catcgtaatg      600
ggtggtcgtg ccatcctggc cgcctctacc aacaagctga aggtcaagcg tgactactct      660
gtgtctgtga tcgccaaggc gagctacgaa gggcttaccg gccagttgag cgcagaagcc      720
aaagccaagt atggcgagtc gatcagcagc ttcactcagt actccagcac ccaccaggaa      780
gtgcgcggcg gcgacggtac caaggcacat ggtgtgttcg aaggcaaagc aggtttccag      840
gcctgggtag acagcgtggg cacctcgccg gacttcgtcg atttcgtccc caccatccct      900
atgctggaaa tctggtccct gtgcaaaacc gactctcagg ccgaggccat gaaacgtcat      960
ttcgataccg tctgggcgcg tgagcaatct gacaagtacc gtatcaaggc taactacatc     1020
gaccaactgg tggtcatcac cggcggtagt tcaaccatcg aaccaccggt cggctacacc     1080
aagatcccgt acgacctcaa tgccggtgcc ggcggtgact tcatctactt gtgctatcac     1140
gaacaaacct ggcaggccga caggcctaaa gatgctgtga cggatatcag gatcattttc     1200
aacaaggagc ctaccccacc tggctatacc aagctgcccc aggacctgaa caagggcgcg     1260
ggcggtgctg atatctacct gtgctacaag ctggagggtt acaacaccga caccgcaatc     1320
aacaagatca cggtcatcag cggcaacaat ccggatatca acgctcctta tggttatgag     1380
aaggtccctg gtgacctgaa caaaggtgct aaaggcaact tcatctatgc ctgtaccttc     1440
gtaggcaag                                                             1449

<210>  82
<211>  1452
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  82
atggaacacg tagacctgcc aacgggtctg gtaaaatttt cctctaatca ccacctgcaa       60
ctgctgcgtg atacggcaga tctgagcgaa tccgtactgc ctggcgtcga agccattggt      120
ctgggctata acccattcct gggttatgcc agtgtcaaca gcggcgcggt gcaattgttc      180
gactgggcca cggccaagaa acgcgaagtg cctttcaaag ccggctactt cgtacccgag      240
atcgtcgacg tgcaacagaa cgacagcgca acctacacca acgtcagcgg caacacgatc      300
agcgagtacc agcgcagtct ggctgtcagc gtcgccatcg aaggcaaata caacttcttc      360
agcggctctc tgtccacgga ttacgacgaa aattctctgc gcaacgcgga aaacgagttc      420
actcgcattc agcaatctat caacctgtgg tctctgcgcc tgccttctgt gaagtctctg      480
cgcgacctga tgctgccaca catgcgcgaa caactggatg aactggacgt caaaaacccg      540
agcgccatca gccgcttttt cgatcgtgtt ggcagccatt tcctgaccgg catcgtaatg      600
ggtggacggg ccatcctggc cgcctctacc aacaagctga aggtcaagcg tgactactct      660
gtgtctgtga tcgccaaggc gagctacgaa ggtctgaccg accagttgag cgcagaagcc      720
aaagccaagt atggcgagtc gatcagcagc ttcactcagt actccaatac ccaccaggaa      780
gtgcgcggcg gcgacggtgc caaggcacat ggggtgttca gcggcaaaaa agaagatttc      840
caggcctggg tagacagtgt gagcgcctcg ccggacttcg tcgatttcgt ccccaccatc      900
cccatgcagg aaatctggac cctgtgcagc agcgaggcgc aggccgaggc catgcgcaag      960
cattacgatg acgtctgggc gccggcgcaa tcggaaaagt accgggtcaa ggctaactac     1020
atcgaccaac tggtggtcat caccggcgat agctctacca tcgaaccacc ggtcggctac     1080
agcaagatcg agtacgacct caatgccggt gccggcggtg acttcatcta cttgtgctat     1140
cacgaacaaa cctggcaggc cgacaggcct aaagatgctg tgacggatat caggatcatt     1200
tacaacaagg agcctacccc acctggctat accaagctgc cccaggacct gaacaagggc     1260
gcgggcggtg atgatgtatt cctctgctac aagaccgagg cttacaacac cgacaccgca     1320
atcaacaagg tcacggtcat cggcggcaac aatccggata tcaacgctcc ttatggttat     1380
gagaaggtcc ctggtgacct gaacaaaggt gctggcggca acttcatcta tgcctgtacc     1440
ttcgtaggca ag                                                         1452

<210>  83
<211>  1449
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  83
atggaaaaca tagacttgcc acaaggactt gtaaactttt ccacgcaaca cctgcaactt       60
attcgtttta aagcaggttt gaatgaaacc gtactacctg gcgtcgaagc cattggactt      120
ggctataacc cattcatcag ttatgccagt gtcaacagcg gcgcggtgca attgttcgac      180
tgggccacgg ccaagaaacg cgaagtgcct ttcaaagccg gctacttcgt acccgagatc      240
gtcgacgtgc aacagaacga cagcgcaacc tacaccaacg tcagcggcaa cacgatcagc      300
gagtaccagc gcagtctggc taccagcgtc gccatcgaag gccgttacaa cttcttcagt      360
ggctcgctgt ccacggattt cgacgaaaat tctctgcgca acgcggaaaa cgagttcact      420
cgcattcagc aatctatcaa cctgtggtct ctgcgcctgc cttctgtgaa gtctctgcgc      480
gacctgatgc tgccacacat gcgccaacaa ctagatgaat tgaacgtcaa cgacccgaag      540
gccataagcc gctatttcga tagagttggc agccatttcc ttaccggcat cgtaatgggt      600
ggacgggcca tcctcgcctc ctcgaccaac aagctcaggg tcaagcgtga ctactcggtg      660
tctgtgatcg ccaaggcgag ctacgaaggt ctgaccggcc agctgagcgc aaaagcccgt      720
accaagtatg gcgagtctat gagcagcttc actcagtact ccagcaccca ccaggaagtg      780
cgcggcggcg acggtgccaa ggcacatggg gtgttcagcg gcaaaaaaga agatttccag      840
gcctgggtag acagtgtgag cgcctctccg gacttcgtcg atttcgtccc taccatccct      900
atgcaggaaa tctggaccct gtgcagcagc gaggcgcagg ccgaggccat gcgcaagcat      960
tacgatgacg tctgggcgcc ggcgcaatcg gaaaagtacc gtatcaaggc taactacatc     1020
gaccaactgg tggtcatcac cggcgatagc tctaccatcg aaccaccggc cggctacacc     1080
aagatcccgt acgacctgaa tgccggtgcc aaaggtgact tcatctacct gtgctatcac     1140
gaacaagcct ggtaccctga caacactaaa cctgctgtga cggctatcaa gatcatttac     1200
gaccgtgagc ctgtcccaac tggctatatc aagctgcctc aggacctgaa caagggcgcg     1260
ggcggtgatg atgtattcct ctgctacaag accgaggctt acaacaccga caccgcaatc     1320
aacaaggtca cggtcatcgg cggcaacaat gcggatatca acgctcccta tggttatctg     1380
aaggtccccg gtgacctcaa cagaggtgct ggcggcaact tcatctatgc ctgtaccttc     1440
gtaggcaag                                                             1449

<210>  84
<211>  1449
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  84
atggaacacg tagacctgcc aacgggtctg gtaaaatttt cctctaatca ccacctgcaa       60
ctgctgcgtg atacggcaga tctgagcgaa tccgtactgc ctggcgtcga agccattggt      120
ctgggctata acccattcct gggttatgcc agtgtcaaca gcggcgcggt gcaattgttc      180
gactgggcca cggccaagaa acgcgaagtg cctttcaaag ccggctactt cgtacccgag      240
atcgtcgacg tgcaacagaa cgacagcgca acctacacca acgtcagcgg caacacgatc      300
agcgagtacc agcgcagtct ggctaccagc gtcgccatcg aaggcaaata caacttcttc      360
agcggctctc tgtccacgga ttacgacgaa aattctctgc gcaacgcgga aaacgagttc      420
actcgcattc agcaatctat caacctgtgg tctctgcgcc tgccttctgt gaagtctctg      480
cgcgacctga tgctgccaca catgcgcgaa caactggatg aactggacgt caaaaacccg      540
agcgccatca gccgctattt cgatagagtt ggcagccatt tcctgaccgg catcgtaatg      600
ggtggtcgtg ccatcctggc cgcctctacc aacaagctga aggtcaagcg tgactactct      660
gtgtctgtga tcgccaaggc gagctacgaa ggtctgaccg gccagctgag cgcagaagcc      720
cgtaccaagt atggcgagtc tatgagcagc ttcactcagt actccagcac ccaccaggaa      780
gtgcgcggcg gcgacggtac caaggcacat ggtgtgttcg aaggcaaagc aggtttccag      840
gcctgggtag acagcgtggg cacctctccg gacttcgtcg atttcgtccc caccatcccc      900
atgcaggaaa tctggaccct gtgcagcagc gaggcgcagg ccgaggccat gcgcaagcat      960
tacgatgacg tctgggcgcc ggcgcaatcg gaaaagtacc gggtcaaggc taactacatc     1020
gaccaactgg tggtcatcac cggcggtagt tcaaccatcg aaccaccggt cggctacacc     1080
aagatcccgt acgacctgaa tgccggtgcc ggcggtgact tcatctactt gtgctatcac     1140
gaacaaacct ggcaggccga caggcctaaa gatgctgtga cggatatcag gatcattttc     1200
aacaaggagc ctaccccacc tggctatacc aagctgcccc aggacctgaa caagggcgcg     1260
ggcggtgatg atatctacct gtgctacaag ctggagggtt acaacaccga caccgcaatc     1320
aacaagatca cggtcatcag cggcaacaat ccggatatca acgctcccta tggttatctg     1380
aaggtccccg gtgacctcaa cagaggtgct ggcggcaact tcatctatgc ctgtaccttc     1440
gtaggcaag                                                             1449

<210>  85
<211>  1446
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  85
atggaaaaca tagacttgcc acaaggactt gtaaactttt ccacgcaaca cctgcaactt       60
attcgtttta aagcaggttt gaatgaaacc gtactacctg gcgtcgaagc cattggactt      120
ggctataacc cattcatcag ttatgccagt gtcaacagcg gcgcggtgca attgttcgac      180
tgggccacgg ccaagaaacg cgaagtgcct ttcaaacctg aattcgtcgt acccgagatc      240
gtcgacgtgc aacagaacga cagcgcaacc tacaccaacg tcagcggcaa cacgatcagc      300
gagtaccagc gcagtctggc taccagcgtc gccatcgaag gccgttacaa cttcttcagt      360
ggctctctgt ccacggatta cgacgaaaat tctctgcgca acgcggaaaa cgagttcact      420
cgcattcagc aatctatcaa cctgtggtct ctgcgcctgc cttctgtgaa gtctctgcgc      480
gacctgatgc tgccacacat gcgcgaacaa ctggatgaac tggacgtcaa aaacccgagc      540
gccatcagcc gctttttcga tcgtgttggc agccatttcc ttaccggcat cgtaatgggt      600
ggtcgtgcca tcctggccgc ctctaccaac aagctgaagg tcaagcgtga ctactctgtg      660
tctgtgatcg ccaaggcgag ctacgaaggt ctgaccggcc agctgagcgc agaagcccgt      720
accaagtatg gcgagtctat gagcagcttc actcagtact ccagcaccca ccaggaagtg      780
cgcggcggcg acggtaccaa ggcacatggt gtgttcgaag gcaaagcagg tttccaggcc      840
tgggtagaca gtgtgagcgc ctcgccggac ttcgtcgatt tcgtccccac catccccatg      900
caggaaatct ggaccctgtg cagcagcgag gcgcaggccg aggccatgcg caagcattac      960
gatgacgtct gggcgccggc gcaatcggaa aagtaccggg tcaaggctaa ctacatcgac     1020
caactggtgg tcatcaccgg cgatagctct accatcgaac caccggtcgg ctacagcaag     1080
atcgagtacg acctcaatgc cggtgccggc ggtgacttca tctacttgtg ctatcacgaa     1140
caaacctggc aggccgacag gcctaaagat gctgtgacgg atatcaggat cattttcaac     1200
aaggagccta ccccaactgg ctatatcaag ctgcctcagg acctgaacaa gggcgcgggc     1260
ggtgctgata tctacctgtg ctacaagctg gagggttaca acaccgacac cgcaatcaac     1320
aagatcacgg tcatcagcgg caacaatccg gatatcaacg ctccttatgg ttatgagaag     1380
gtccctggtg acctcaacag aggtgctggc ggcaacttca tctatgcctg taccttcgta     1440
ggcaag                                                                1446

<210>  86
<211>  1446
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  86
atggaaaaca tagacttgcc acaaggactt gtaaactttt ccacgcaaca cctgcaactt       60
attcgtttta aagcaggttt gaatgaaacc gtactacctg gcgtcgaagc cattggactt      120
ggctataacc cattcatcag ttatgccagt gtcaacagcg gcgcggtgca attgttcgac      180
tgggccacgg ccaagaaacg cgaagtgcct ttcaaagccg gctacttcgt acccgagatc      240
gtcgacgtgc aacagaacga cagcgcaacc tacaccaacg tcagcggcaa cacgatcagc      300
gagtaccagc gcagtctggc taccagcgtc gccatcgaag gccgttacaa cttcttcagt      360
ggctcgctgt ccacggattt cgacagtaat tcactgcgca acgcggaaaa cgagttcact      420
cgcattcagc aatcgatcaa cctgtggtct ctgcgcctgc cttctgtgaa gtctctgcgc      480
gacctgatgc tgccacacat gcgcgaacaa ctggatgaac tggacgtcaa cgacccgaag      540
gccataagcc gctatttcga tagagttggc agccatttcc ttaccggcat cgtaatgggt      600
ggacgggcca tcctcgcctc ctcgaccaac aagctcaggg tcaagcgtga ctactcggtg      660
tcggtggtcg ccaaggcgag ctacgaaggt ctgaccggcc agctgagcgc agaagcccgt      720
accaagtatg gcgagtctat gagcagcttc actcagtact ccagcaccca ccaggaagtg      780
cgcggcggcg acggtaccaa ggcacatggt gtgttcgaag gcaaagcagg tttccaggcc      840
tgggtagaca gcgtgggcac ctctccggac ttcgtcgatt tcgtccctac catccctatg      900
ctggaaatct ggtccctgtg caaaaccgac tctcaggccg aggccatgaa acgtcatttc      960
gataccgtct gggcgcgtga gcaatctgac aagtaccgta tcaaggctaa ctacatcgac     1020
caactggtgg tcatcaccgg cgatagctct accatcgaac caccggccgg ctacaccaag     1080
atcccgtacg acctgaatgc cggtgccaaa ggtgacttca tctacctgtg ctatcacgaa     1140
caagcctggt accctgacaa cactaaacct gctgtgacgg ctatcaagat catttacgac     1200
cgtgagcctg tcccaactgg ctatatcaag ctgcctcagg acctgaacaa gggcgcgggc     1260
ggtgatgatg tattcctctg ctacaagacc gaggcttaca acaccgacac cgcaatcaac     1320
aaggtcacgg tcatcggcgg caacaatgcg gatatcaacg ctccctatgg ttatctgaag     1380
gtccccggtg acctcaacag aggtgctggc ggcaacttca tctatgcctg taccttcgta     1440
ggcaag                                                                1446

<210>  87
<211>  1449
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  87
atggaaaaca tagacttgcc acaaggactt gtaaactttt ccacgcaaca cctgcaactt       60
attcgtttta aagcaggttt gaatgaaacc gtactacctg gcgtcgaagc cattggactt      120
ggctataacc cattcatcag ttatgccagt gtcaacagcg gcgcggtgca attgttcgac      180
tgggccacgg ccaagaaacg cgaagtgcct ttcaaagccg gctacttcgt acccgagatc      240
gtcgacgtgc aacagaacga cagcgcaacc tacaccaacg tcagcggcaa cacgatcagc      300
gagtaccagc gcagtctggc taccagcgtc gccatcgaag gccgttacaa cttcttcagt      360
ggctcgctgt ccacggattt cgacagtaat tcactgcgca acgcggaaaa cgagttcact      420
cgcattcagc aatcgatcaa cctctggtcg ttgcgcttgc cttcggtgaa gtcattgcgc      480
gaactgatgc tgccacacat gcgccaacaa ctagatgaat tgaacgtcaa cgacccgaag      540
gccataagcc gctatttcga tagagttggc agccatttcc ttaccggcat cgtaatgggt      600
ggtcgtgcca tcctggccgc ctctaccaac aagctgaagg tcaagcgtga ctactctgtg      660
tctgtgatcg ccaaggcgag ctacgaaggt ctgaccggcc agctgagcgc agaagccaaa      720
gccaagtatg gcgagtcgat cagcagcttc actcagtact ccaataccca ccaggaagtg      780
cgcggcggcg acggtgccaa ggcacatggg gtgttcagcg gcaaaaaaga agatttccag      840
gcctgggtag acagtgtgag cgcctcgccg gacttcgtcg atttcgtccc caccatcccc      900
atgcaggaaa tctggaccct gtgcagcagc gaggcgcagg ccgaggccat gcgcaagcat      960
tacgatgacg tctgggcgcc ggcgcaatcg gaaaagtacc gggtcaaggc taactacatc     1020
gaccaactgg tggtcatcac cggcggtagt tcaaccatcg aaccaccggc cggctacacc     1080
aagatcgagt acgacctcaa tgccggtgcc ggcggtgact tcatctactt gtgctatcac     1140
gaacaagcct ggtaccctga caacactaaa cctgctgtga cggctatcaa gatcatttac     1200
gaccgtgagc ctgtcccaac tggctatatc aagctgcctc aggacctgaa caagggcgcg     1260
ggcggtgctg atatctacct gtgctacaag ctggagggtt acaacaccga caccgcaatc     1320
aacaaggtca cggtcatcgg cggcaacaat gcggatatca acgctcccta tggttatctg     1380
aaggtccccg gtgacctcaa cagaggtgct ggcggcaact tcatctatgc ctgtaccttc     1440
gtaggcaag                                                             1449

<210>  88
<211>  1446
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  88
atggaaaaca tagacttgcc acaaggactt gtaaactttt ccacgcaaca cctgcaactt       60
attcgtttta aagcaggttt gaatgaaacc gtactacctg gcgtcgaagc cattggactt      120
ggctataacc cattcatcag ttatgccagt gtcaacagcg gcgcggtgca attgttcgac      180
tgggccacgg ccaagaaacg cgaagtgcct ttcaaagccg gctacttcgt acccgagatc      240
gtcgacgtgc aacagaacga cagcgcaacc tacaccaacg tcagcggcaa cacgatcagc      300
gagtaccagc gcagtctggc taccagcgtc gccatcgaag gccgttacaa cttcttcagt      360
ggctcgctgt ccacggattt cgacagtaat tcactgcgca acgcggaaaa cgagttcact      420
cgcattcagc aatcgatcaa cctctggtcg ttgcgcttgc cttcggtgaa gtcattgcgc      480
gaactgatgc tgccacacat gcgccaacaa ctagatgaat tgaacgtcaa cgacccgaag      540
gccataagcc gctatttcga tagagttggc agccatttcc ttaccggcat cgtaatgggt      600
ggacgggcca tcctcgcctc ctcgaccaac aagctcaggg tcaagcgtga ctactctgtg      660
tctgtgatcg ccaaggcgag ctacgaaggt ctgaccggcc agctgagcgc agaagcccgt      720
accaagtatg gcgagtctat gagcagcttc actcagtact ccagcaccca ccaggaagtg      780
cgcggcggcg acggtaccaa ggcacatggt gtgttcgaag gcaaagcagg tttccaggcc      840
tgggtagaca gcgtgggcac ctctccggac ttcgtcgatt tcgtccccac catccccatg      900
caggaaatct ggaccctgtg cagcagcgag gcgcaggccg aggccatgcg caagcattac      960
gatgacgtct gggcgccggc gcaatcggaa aagtaccggg tcaaggctaa ctacatcgac     1020
caactggtgg tcatcaccgg cggtagttca accatcgaac caccggtcgg ctacagcaag     1080
atcgagtacg acctcaatgc cggtgccggc ggtgacttca tctacttgtg ctatcacgaa     1140
caaacctggc aggccgacag gcctaaagat gctgtgacgg atatcaggat cattttcaac     1200
aaggagccta ccccacctgg ctataccaag ctgccccagg acctgaacaa gggcgcgggc     1260
ggtgatgatg tattcctctg ctacaagacc gaggcttaca acaccgacac cgcaatcaac     1320
aaggtcacgg tcatcggcgg caacaatgcg gatatcaacg ctccctatgg ttatctgaag     1380
gtccccggtg acctcaacag aggtgctggc ggcaacttca tctatgcctg taccttcgta     1440
ggcaag                                                                1446

<210>  89
<211>  1449
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  89
atggaaaaca tagacttgcc acaaggactt gtaaactttt ccacgcaaca cctgcaactt       60
attcttttta tagcatgttt gaatgaaacc gtactacctg gcgtcgaagc cattggactt      120
ggctataacc cattcatcag ttatgccagt gtcaacagcg gcgcggtgca attgttcgac      180
tgggccacgg ccaagaaacg cgaagtgcct ttcaaagccg gctacttcgt acccgagatc      240
gtcgacgtgc aacagaacga cagcgcaacc tacaccaacg tcagcggcaa cacgatcagc      300
gagtaccagc gcagtctggc taccagcgtc gccatcgaag gccgttacaa cttcttcagt      360
ggctcgctgt ccacggattt cgacagtaat tcactgcgca acgcggaaaa cgagttcact      420
cgcattcagc aatcgatcaa cctctggtcg ttgcgcttgc cttcggtgaa gtcattgcgc      480
gaactgatgc tgccacacat gcgccaacaa ctagatgaat tgaacgtcaa cgacccgaag      540
gccataagcc gctatttcga tagagttggc agccatttcc ttaccggcat cgtaatgggt      600
ggacgggcca tcctcgcctc ctcgaccaac aagctcaggg tcaagcgtga ctactcggtg      660
tcggtggtcg ccaaggcgag ctacgaaggg cttaccggcc agttgagcgc agaagccaaa      720
gccaagtatg gcgagtcgat cagcagcttc actcagtact ccaataccca ccaggaagtg      780
cgcggcggcg acggtgccaa ggcacatggg gtgttcagcg gcaaaaaaga agatttccag      840
gcctgggtag acagtgtgag cgcctcgccg gacttcgtcg atttcgtccc caccatcccc      900
atgcaggaaa tctggaccct gtgcagcagc gaggcgcagg ccgaggccat gcgcaagcat      960
tacgatgacg tctgggcgcc ggcgcaatcg gaaaagtacc gggtcaaggc taactacatc     1020
gaccaactgg tggtcatcac cggcggtagt tcaaccatcg aaccaccggt cggctacagc     1080
aagatcgagt acgacctcaa tgccggtgcc ggcggtgact tcatctactt gtgctatcac     1140
gaacaaacct ggcaggccga caggcctaaa gatgctgtga cggatatcag gatcattttc     1200
aacaaggagc ctaccccacc tggctatacc aagctgcccc aggacctgaa caagggcgcg     1260
ggcggtgatg atgtattcct ctgctacaag accgaggctt acaacaccga caccgcaatc     1320
aacaaggtca cggtcatcgg cggcaacaat gcggatatca acgctcccta tggttatctg     1380
aaggtccccg gtgacctcaa cagaggtgct ggcggcaact tcatctatgc ctgtaccttc     1440
gtaggcaag                                                             1449

<210>  90
<211>  1449
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  90
atggaaaaca tagacttgcc acaaggactt gtaaactttt ccacgcaaca cctgcaactt       60
attcgtttta aagcaggttt gaatgaaacc gtactacctg gcgtcgaagc cattggactt      120
ggctataacc cattcatcag ttatgccagt gtcaacagcg gcgcggtgca attgttcgac      180
tggaacaacg ccaagaaaaa aaaagtgtct ttcaaacctg aattcgtcgt acctgagatc      240
gtcgacgtgc aacagaacga cagcgcaacc tacaccaacg tcagcggcaa cacggtcacc      300
gagtaccagc gcagtctggc taccagcgtc gccatcgaag gccgttacaa cttcttcagt      360
ggctcgctgt ccacggatta cgacgaaaat tctctgcgca acgcggaaaa cgagttcact      420
cgcattcagc aatcgatcaa cctctggtcg ttgcgcctgc cttctgtgaa gtctctgcgc      480
gacctgatgc tgccacacat gcgcgaacaa ctggatgaac tggacgtcaa aaacccgagc      540
gccatcagcc gctttttcga tcgtgttggc agccatttcc tgaccggcat cgtaatgggt      600
ggtcgtgcca tcctggccgc ctctaccaac aagctgaagg tcaagcgtga ctactctgtg      660
tcggtggtcg ccaaggcgag ctacgaaggg cttaccggcc agttgagcgc agaagccaaa      720
gccaagtatg gcgagtcgat cagcagcttc actcagtact ccaataccca ccaggaagtg      780
cgcggcggcg acggtgccaa ggcacatggg gtgttcagcg gcaaaaaaga agatttccag      840
gcctgggtag acagtgtgag cgcctcgccg gacttcgtcg atttcgtccc caccatccct      900
atgctggaaa tctggaccct gtgcagcagc gaggcgcagg ccgaggccat gcgcaagcat      960
tacgatgacg tctgggcgcc ggcgcaatcg gaaaagtacc gggtcaaggc taactacatc     1020
gaccaactgg tggtcatcac cggcggtagt tcaaccatcg aaccaccggt cggctacagc     1080
aagatcgagt acgacctcaa tgccggtgcc ggcggtgact tcatctactt gtgctatcac     1140
gaacaaacct ggcaggccga caggcctaaa gatgctgtga cggatatcag gatcattttc     1200
aacaaggagc ctaccccacc tggctatacc aagctgcccc aggacctgaa caagggcgcg     1260
ggcggtgatg atgtattcct ctgctacaag accgaggctt acaacaccga caccgcaatc     1320
aacaaggtca cggtcatcgg cggcaacaat gcggatatca acgctcccta tggttatctg     1380
aaggtccccg gtgacctcaa cagaggtgct ggcggcaact tcatctatgc ctgtaccttc     1440
gtaggcaag                                                             1449

<210>  91
<211>  1446
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  91
atggaaaaca tagacttgcc acaaggactt gtaaactttt ccacgcaaca cctgcaactt       60
attcgtttta aagcaggttt gaatgaaacc gtactacctg gcgtcgaagc cattggtctg      120
ggctataacc cattcctggg ttatgccagt gtcaacagcg gcgcggtgca attgttcgac      180
tgggccacgg ccaagaaacg cgaagtgcct ttcaaagccg gctacttcgt acccgagatc      240
gtcgacgtgc aacagaacga cagcgcaacc tacaccaacg tcagcggcaa cacgatcagc      300
gagtaccagc gcagtctggc taccagcgtc gccatcgaag gccgttacaa cttcttcagc      360
ggctctctgt ccacggatta cgacgaaaat tctctgcgca acgcggaaaa cgagttcact      420
cgcattcagc aatctatcaa cctgtggtct ctgcgcctgc cttctgtgaa gtctctgcgc      480
gacctgatgc tgccacacat gcgccaacaa ctagatgaat tgaacgtcaa cgacccgaag      540
gccataagcc gctatttcga tagagttggc agccatttcc ttaccggcat cgtaatgggt      600
ggtcgtgcca tcctggccgc ctctaccaac aagctcaggg tcaagcgtga ctactcggtg      660
tctgtgatcg ccaaggcgag ctacgaaggt ctgaccggcc agctgagcgc agaagcccgt      720
accaagtatg gcgagtctat gagcagcttc actcagtact ccagcaccca ccaggaagtg      780
cgcggcggcg acggtaccaa ggcacatggt gtgttcgaag gcaaagcagg tttccaggcc      840
tgggtagaca gcgtgggcac ctctccggac ttcgtcgatt tcgtccctac catccctatg      900
ctggaaatct ggaccctgtg cagcagcgag gcgcaggccg aggccatgcg caagcattac      960
gatgacgtct gggcgccggc gcaatcggaa aagtaccggg tcaaggctaa ctacatcgac     1020
caactggtgg tcatcaccgg cggtagttca accatcgaac caccggtcgg ctacagcaag     1080
atcgagtacg acctcaatgt cggtgccggc ggtgacttca tctacttgtg ctatcacgaa     1140
caaacctggc aggccgacag gcctaaagat gctgtgacgg atatcaggat cattttcaac     1200
aaggagccta ccccacctgg ctataccaag ctgccccagg acctgaacaa gggcgcgggc     1260
ggtgatgatg tattcctctg ctacaagacc gaggcttaca acaccgacac cgcaatcaac     1320
aaggtcacgg tcatcggcgg caacaatgcg gatatcaacg ctccttatgg ttatgagaag     1380
gtccctggtg acctgaacaa aggtgctaaa ggcaacttca tctatgcctg taccttcgta     1440
ggcaag                                                                1446

<210>  92
<211>  1446
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  92
atggaaaaca tagacttgcc acaaggactt gtaaactttt ccacgcaaca cctgcaactt       60
attcgtttta aagcaggttt gaatgaaacc gtactacctg gcgtcgaagc cattggactt      120
ggctataacc cattcatcag ttatgccagt gtcaacagcg gcgcggtgca attgttcgac      180
tgggccacgg ccaagaaacg cgaagtgcct ttcaaagccg gctacttcgt acccgagatc      240
gtcgacgtgc aacagaacga cagcgcaacc tacaccaacg tcagcggcaa cacggtcagc      300
gagtaccagc gcagtctggc taccagcgtc gccatcgaag gccgttacaa cttcttcagc      360
ggctctctgt ccacggatta cgacgaaaat tctctgcgca acgcggaaaa cgagttcact      420
cgcattcagc aatctatcaa cctgtggtct ctgcgcctgc cttctgtgaa gtctctgcgc      480
gacctgatgc tgccacacat gcgcgaacaa ctggatgaac tggacgtcaa aaacccgagc      540
gccatcagcc gctttttcga tcgtgttggc agccatttcc ttaccggcat cgtaatgggt      600
ggacgggcca tcctcgcctc ctcgaccaac aagctcaggg tcaagcgtga ctactcggtg      660
tcggtggtcg ccaaggcgag ctacgaaggt ctgaccggcc agctgagcgc agaagcccgt      720
accaagtatg gcgagtctat gagcagcttc actcagtact ccagcaccca ccaggaagtg      780
cgcggcggcg acggtaccaa ggcacatggt gtgttcgaag gcaaagcagg tttccaggcc      840
tgggtagaca gtgtgagcgc ctcgccggac ttcgtcgatt tcgtccccac catccccatg      900
caggaaatct ggaccctgtg cagcagcgag gcgcaggccg aggccatgcg caagcattac      960
gatgacgtct gggcgccggc gcaatcggaa aagtaccggg tcaaggctaa ctacatcgac     1020
caactggtgg tcatcaccgg cgatagctct accatcgaac caccggccgg ctacaccaag     1080
atcccgtacg acctgaatgc cggtgccaaa ggtgacttca tctacctgtg ctatcacgaa     1140
caagcctggt accctgacaa cactaaacct gctgtgacgg ctatcaagat catttacgac     1200
cgtgagcctg tcccaactgg ctatatcaag ctgcctcagg acctgaacaa gggcgcgggc     1260
ggtgctgata tctacctgtg ctacaagctg gagggttaca acaccgacac cgcaatcaac     1320
aagatcacgg tcatcagcgg caacaatccg gatatcaacg ctccttatgg ttatctgaag     1380
gtccccggtg acctcaacag aggtgctaaa ggcaacttca tctatgcctg taccttcgta     1440
ggcaag                                                                1446

<210>  93
<211>  1446
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  93
atggaaaaca tagacttgcc acaaggactt gtaaactttt ccacgcaaca cctgcaactt       60
attcgtttta aagcaggttt gaatgaaacc gtactacctg gcgtcgaagc cattggactt      120
ggctataacc cattcatcag ttatgccagt gtcaacagcg gcgcggtgca attgttcgac      180
tgggccacgg ccaagaaacg cgaagtgcct ttcaaagccg gctacttcgt acccgagatc      240
gtcgacgtgc aacagaacga cagcgcatcc tacaccaacg tcagcggcaa cacgatcagc      300
gagtaccagc gcagtctggc taccagcgtc gccatcgaag gccgttacaa cttcttcagc      360
ggctctctgt ccacggatta cgacgaaaat tctctgcgca acgcggaaaa cgagttcact      420
cgcattcagc aatctatcaa cctgtggtct ctgcgcctgc cttctgtgaa gtctctgcgc      480
gacctgatgc tgccacacat gcgcgaacaa ctggatgaac tggacgtcaa aaacccgagc      540
gccatcagcc gctttttcga tcgtgttggc agccatttcc tgaccggcat cgtaatgggt      600
ggtcgtgcca tcctggccgc ctctaccaac aagctgaagg tcaagcgtga ctactctgtg      660
tctgtgatcg ccaaggcgag ctacgaaggg cttaccggcc agttgagcgc agaagccaaa      720
gccaagtatg gcgagtcgat cagcagcttc actcagtact ccaataccca ccaggaagtg      780
cgcggcggcg acggtaccaa ggcacatggt gtgttcgaag gcaaagcagg tttccaggcc      840
tgggtagaca gcgtgggcac ctctccggac ttcgtcgatt tcgtccctac catccctatg      900
ctggaaatct ggaccctgtg cagcagcgag gcgcaggccg aggccatgcg caagcattac      960
gatgacgtct gggcgccggc gcaatcggaa aagtaccggg tcaaggctaa ctacatcgac     1020
caactggtgg tcatcaccgg cgatagctct accatcgaac caccggccgg ctacaccaag     1080
atcccgtacg acctgaatgc cggtgccaaa ggtgacttca tctacctgtg ctatcacgaa     1140
caagcctggt accctgacaa cactaaacct gctgtgacgg ctatcaagat catttacgac     1200
cgtgagcctg tcccaactgg ctatatcaag ctgcctcagg acctgaacaa gggcgcgggc     1260
ggtgctgata tctacctgtg ctacaagacc gaggcttaca acaccgacac cgcaatcaac     1320
aaggtcacgg tcatcggcgg caacaatgcg gatatcaacg ctccctatgg ttatctgaag     1380
gtccccggtg acctcaacag aggtgctggc ggcaacttca tctatgcctg taccttcgta     1440
ggcaag                                                                1446

<210>  94
<211>  1449
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  94
atggaaaaca tagacttgcc acaaggactt gtaaactttt ccacgcaaca cctgcaactt       60
attcgtttta aagcaggttt gaatgaaacc gtactacctg gcgtcgaagc cattggactt      120
ggctataacc cattcatcag ttatgccagt gtcaacagcg gcgcggtgca attgttcgac      180
tgggccacgg ccaagaaacg cgaagtgcct ttcaaagccg gctacttcgt acccgagatc      240
gtcgacgtgc aacagaacga cagcgcaacc tacaccaacg tcagcggcaa cacgatcagc      300
gagtaccagc gcagtctggc taccagcgtc gccatcgaag gccgttacaa cttcttcagt      360
ggctcgctgt ccacggattt cgacagtaat tcactgcgca acgcggaaaa cgagttcact      420
cgcattcagc aatcgatcaa cctctggtcg ttgcgcttgc cttcggtgaa gtcattgcgc      480
gaactgatgc tgccacacat gcgcgaacaa ctggatgaac tggacgtcaa aaacccgagc      540
gccatcagcc gctttttcga tcgtgttggc agccatttcc tgaccggcat cgtaatgggt      600
ggtcgtgcca tcctcgcctc ctcgaccaac aagctcaggg tcaagcgtga ctactcggtg      660
tcggtggtcg ccaaggcgag ctacgaaggg cttaccggcc agttgagcgc agaagccaaa      720
gccaagtatg gcgagtcgat cagcagcttc actcagtact ccaataccca ccaggaagtg      780
cgcggcggcg acggtgccaa ggcacatggg gtgttcagcg gcaaaaaaga agatttccag      840
gcctgggtag acagtgtgag cgcctcgccg gacttcgtcg atttcgtccc caccatcccc      900
atgcaggaaa tctggaccct gtgcagcagc gaggcgcagg ccgaggccat gcgcaagcat      960
tacgatgacg tctgggcgcc ggcgcaatcg gaaaagtacc gggtcaaggc taactacatc     1020
gaccaactgg tggtcatcac cggcgatagc tctaccatcg aaccaccggc cggctacacc     1080
aagatcccgt acgacctgaa tgccggtgcc aaaggtgact tcatctacct gtgctatcac     1140
gaacaagcct ggtaccctga caacactaaa cctgctgtga cggctatcaa gatcatttac     1200
gaccgtgagc ctgtcccaac tggctatatc aagctgcctc aggacctgaa caagggcgcg     1260
ggcggtgctg atatctacct gtgctacaag accgaggctt acaacaccga caccgcaatc     1320
aacaaggtca cggtcatcgg cggcaacaat gcggatatca acgctcctta tggttatgag     1380
aaggtccctg gtgacctgaa caaaggtgct aaaggcaact tcatctatgc ctgtaccttc     1440
gtaggcaag                                                             1449

<210>  95
<211>  1449
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  95
atggaaaaca tagacttgcc acaaggactt gtaaactttt ccacgcaaca cccgcaactt       60
attcgtttta aagcaggttt gaatgaaacc gtactacctg gcgtcgaagc cattggactt      120
ggctataacc cattcatcag ttatgccagt gtcaacagcg gcgcggtgca attgttcgac      180
tgggccacgg ccaagaaacg cgaagtgcct ttcaaagccg gctacttcgt acccgagatc      240
gtcgacgtgc aacagaacga cagcgcaacc tacaccaacg tcagcgacaa cacggtcacc      300
gagtaccagc gcagcctggc tgtcagcgtc gccatcgaag gcaaatacaa cttcttcagc      360
ggctctctgt ccacggatta cgacgaaaat tctctgcgca acgcggaaaa cgagttcact      420
cgcattcagc aatctatcaa cctgtggtct ctgcgcctgc cttctgtgaa gtctctgcgc      480
gacctgatgc tgccacacat gcgcgaacaa ctggatgaac tggacgtcaa aaacccgagc      540
gccatcagcc gctttttcga tcgtgttggc agccatttcc tgaccggcat cgtaatgggt      600
ggtcgtgcca tcctggccgc ctctaccaac aagctcaggg tcaagcgtga ctactcggtg      660
tcggtggtcg ccaaggcgag ctacgaaggg cttaccggcc agttgagcgc agaagccaaa      720
gccaagtatg gcgagtcgat cagcagcttc actcagtact ccagcaccca ccaggaagtg      780
cgcggcggcg acggtaccaa ggcacatggt gtgttcagcg gcaaaaaaga agatttccag      840
gcctgggtag acagtgtgag cgcctcgccg gacttcgtcg atttcgtccc caccatcccc      900
atgcaggaaa tctggaccct gtgcagcagc gaggcgcagg ccgaggccat gcgcaagcat      960
tacgatgacg tctgggcgcc ggcgcaatcg gaaaagtacc gggtcaaggc taactacatc     1020
gaccaactgg tggtcatcac cggcggtagt tcaaccatcg aaccaccggc cggctacacc     1080
aagatcccgt acgacctgaa tgccggtgcc aaaggtgact tcatctacct gtgctatcac     1140
gaacaagcct ggtaccctga caacactaaa cctgctgtga cggctatcaa gatcatttac     1200
gaccgtgagc ctgtcccaac tggctatatc aagctgcctc aggacctgaa caagggcgcg     1260
ggcggtgctg atatctacct gtgctacaag ctggagggtt acaacaccga caccgcaatc     1320
aacaaggtca cggtcatcag cggcaacaat gcggatatca acgctcccta tggttatctg     1380
aaggtccccg gtgacctcaa cagaggtgct ggcggcaact tcatctatgc ctgtaccttc     1440
gtaggcaag                                                             1449

<210>  96
<211>  1446
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  96
atggaaaaca tagacttgcc acaaggactt gtaaactttt ccacgcaaca cctgcaactt       60
attcgtttta aagcaggttt gaatgaaacc gtactacctg gcgtcgaagc cattggactt      120
ggctataacc cattcatcag ttatgccagt gtcaacagcg gcgcggtgca attgttcgac      180
tgggccacgg ccaagaaacg cgaagtgcct ttcaaagccg gctacttcgt acccgagatc      240
gtcgacgtgc aacagaacga cagcgcaacc tacaccaacg tcagcggcaa cacggtcacc      300
gagtaccagc gcagcctggc tgtcagcgtc gccatcgaag gcaaatacaa cttcttcagc      360
ggctctctgt ccacggatta cgacgaaaat tctctgcgca acgcggaaaa cgagttcact      420
cgcattcagc aatctatcaa cctgtggtct ctgcgcctgc cttctgtgaa gtctctgcgc      480
gacctgatgc tgccacacat gcgcgaacaa ctggatgaac tggacgtcaa aaacccgagc      540
gccatcagcc gctttttcga tcgtgttggc agccatttcc tgaccggcat cgtaatgggt      600
ggtcgtgcca tcctggccgc ctctaccaac aagctgaagg tcaagcgtga ctactctgtg      660
tctgtgatcg ccaaggcgag ctacgaaggt ctgaccggcc agctgagcgc agaagcccgt      720
accaagtatg gcgagtcgat cagcagcttc actcagtact ccaataccca ccaggaagtg      780
cgcggcggcg acggtgccaa ggcacatggt gtgttcgaag gcaaagcagg tttccaggcc      840
tgggtagaca gcgtgggcac ctctccggac ttcgtcgatt tcgtccctac catccccatg      900
caggaaatct ggaccctgtg cagcagcgag gcgcaggccg aggccatgcg caagcattac      960
gatgacgtct gggcgccggc gcaatcggaa aagtaccggg tcaaggctaa ctacatcgac     1020
caactggtgg tcatcaccgg cggtagttca accatcgaac caccggtcgg ctacagcaag     1080
atcgagtacg acctcaatgc cggtgccggc ggtgacttca tctacttgtg ctatcacaaa     1140
caaacctggc aggccgacag gcctaaagat gctgtgacgg atatcaggat cattttcaac     1200
aaggagccta ccccacctgg ctataccaag ctgccccagg acctgaacaa gggcgcgggc     1260
ggtgatgatg tattcctctg ctacaagacc gaggcttaca acaccgacac cgcaatcaac     1320
aagatcacgg tcatcagcgg caacaatccg gatatcaacg ctccttatgg ttatgagaag     1380
gtccctggtg acctgaacaa aggtgctaaa ggcaacttca tctatgcctg taccttcgta     1440
ggcaag                                                                1446

<210>  97
<211>  1449
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  97
atggaaaaca tagacttgcc acaaggactt gtaaactttt ccacgcaaca cctgcaactt       60
attcgtttta aagcaggttt gaatgaaacc gtactacctg gcgtcgaagc cattggactt      120
ggctataacc cattcatcag ttatgccagt gtcaacagcg gcgcggtgca attgttcgac      180
tgggccacgg ccaagaaacg cgaagtgcct ttcaaagccg gctacttcgt acccgagatc      240
gtcgacgtgc aacagaacga cagcgcaacc tacaccaacg tcagcggcaa cacgatcagc      300
gagtaccagc gcagtctggc taccagcgtc gccatcgaag gcaaatacaa cttcttcagt      360
ggctcgctgt ccacggattt cgacagtaat tcactgcgca acgcggaaaa cgagttcact      420
cgcattcagc aatcgatcaa cctctggtcg ttgcgcttgc cttcggtgaa gtcattgcgc      480
gaactgatgc tgccacacat gcgccaacaa ctagatgaat tgaacgtcaa cgacccgaag      540
gccataagcc gctatttcga tagagttggc agccatttcc ttaccggcat cgtaatgggt      600
ggacgggcca tcctcgcctc ctcgaccaac aagctgaagg tcaagcgtga ctactctgtg      660
tctgtgatcg ccaaggcgag ctacgaaggg cttaccggcc agttgagcgc agaagccaaa      720
gccaagtatg gcgagtcgat cagcagcttc actcagtact ccaataccca ccaggaagtg      780
cgcggcggcg acggtgccaa ggcacatggg gtgttcagcg gcaaaaaaga agatttccag      840
gcctgggtag acagtgtgag cgcctcgccg gacttcgtcg atttcgtccc caccatcccc      900
atgcaggaaa tctggaccct gtgcagcagc gaggcgcagg ccgaggccat gcgcaagcat      960
tacgatgacg tctgggcgcc ggcgcaatct gacaagtacc gtatcaaggc taactacatc     1020
gaccaactgg tggtcatcac cggcggtagt tcaaccatcg aaccaccggc cggctacagc     1080
aagatcgagt acgacctcaa tgccggtgcc ggcggtgact tcatctactt gtgctatcac     1140
gaacaaacct ggcaggccga caggcctaaa gatgctgtga cggatatcag gatcattttc     1200
aacaaggagc ctaccccacc tggctatacc aagctgcccc aggacctgaa caagggcgcg     1260
ggcggtgatg atgtattcct ctgctacaag accgaggctt acaacaccga caccgcaatc     1320
aacaaggtca cggtcatcgg cggcaacaat gcggatatca acgctcccta tggttatctg     1380
aaggtccccg gtgacctgaa caaaggtgct aaaggcaact tcatctatgc ctgtaccttc     1440
gtaggcaag                                                             1449

<210>  98
<211>  1449
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  98
atggaaaaca tagacttgcc acaaggactt gtaaactttt ccacgcaaca cctgcaactt       60
attcgtttta aagcaggttt gaatgaaacc gtactacctg gcgtcgaagc cattggactt      120
ggctataacc cattcatcag ttatgccagt gtcaacagcg gcgcggtgca attgttcgac      180
tgggccacgg ccaagaaacg cgaagtgcct ttcaaagccg gctacttcgt acccgagatc      240
gtcgacgtgc aacagaacga cagcgcaacc tacaccaacg tcagcggcaa cacggtcacc      300
gagtaccagc gcagcctggc tgtcagcgtc gccatcgaag gcaaatacaa cttcttcagc      360
ggctctctgt ccacggatta cgacgaaaat tctctgcgca acgcggaaaa cgagttcact      420
cgcattcagc aatcgatcaa cctctggtcg ttgcgcttgc cttcggtgaa gtctctgcgc      480
gacctgatgc tgccacacat gcgccaacaa ctagatgaat tgaacgtcaa cgacccgaag      540
gccataagcc gctatttcga tagagttggc agccatttcc tgaccggcat cgtaatgggt      600
ggacgggcca tcctcgcctc ctcgaccaac aagctcaggg tcaagcgtga ctactcggtg      660
tcggtggtcg ccaaggcgag ctacgaaggg cttaccggcc agttgagcgc agaagccaaa      720
gccaagtatg gcgagtcgat cagcagcttc actcagtact ccaataccca ccaggaagtg      780
cgcggcggcg acggtgccaa ggcacatggg gtgttcagcg gcaaaaaaga agatttccag      840
gcctgggtag acagcgtggg cacctctccg gacttcgtcg atttcgtccc taccatccct      900
atgctggaaa tctggtccct gtgcaaaacc gactctcagg ccgaggccat gaaacgtcat      960
ttcgataccg tctgggcgcg tgagcaatct gacaagtacc gtatcaaggc taactacatc     1020
gaccaactgg tggtcatcac cggcgatagc tctaccatcg aaccaccggc cggctacacc     1080
aagatcccgt acgacctgaa tgccggtgcc aaaggtgact tcatctacct gtgctatcac     1140
gaacaagcct ggtaccctga caacactaaa cctgctgtga cggctatcaa gatcatttac     1200
gaccgtgagc ctgtcccaac tggctatatc aagctgcctc aggacctgaa caagggcgcg     1260
ggcggtgctg atatctacct gtgctacaag ctggagggtt acaacaccga caccgcaatc     1320
aacaagatca cggtcatcag cggcaacaat gcggatatca acgctcccta tggttatctg     1380
aaggtccccg gtgacctcaa cagaggtgct ggcggcaact tcatctatgc ctgtaccttc     1440
gtaggcaag                                                             1449

<210>  99
<211>  1446
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  99
atggaaaaca tagacttgcc acaaggactt gtaaactttt ccacgcaaca cctgcaactt       60
attcgtttta aagcaggttt gaatgaaacc gtactacctg gcgtcgaagc cattggactt      120
ggctataacc cattcatcag ttatgccagt gtcaacagcg gcgcggtgca attgttcgac      180
tgggccacgg ccaagaaacg cgaagtgcct ttcaaagccg gctacttcgt acccgagatc      240
gtcgacgtgc aacagaacga cagcgcaacc tacaccaacg tcagcggcaa cacgatcagc      300
gagtaccagc gcagtctggc taccagcgtc gccatcgaag gccgttacaa cttcttcagt      360
ggctcgctgt ccacggattt cgacagtaat tcactgcgca acgcggaaaa cgagttcact      420
cgcattcagc aatcgatcaa cctctggtcg ttgcgcttgc cttcggtgaa gtcattgcgc      480
gaactgatgc tgccacacat gcgccaacaa ctagatgaat tgaacgtcaa cgacccgaag      540
gccataagcc gctatttcga tagagttggc agccatttcc ttaccggcat cgtaatgggt      600
ggacgggcca tcctcgcctc ctcgaccaac aagctcaggg tcaagcgtga ctactctgtg      660
tctgtgatcg ccaaggcgag ctacgaaggt ctgaccggcc agctgagcgc agaagcccgt      720
accaagtatg gcgagtctat gagcagcttc actcagtact ccagcaccca ccaggaagtg      780
cgcggcggcg acggtaccaa ggcacatggt gtgttcgaag gcaaagcagg tttccaggcc      840
tgggtagaca gcgtgggcac ctctccggac ttcgtcgatt tcgtccctac catccccatg      900
caggaaatct ggaccctgtg cagcagcgag gcgcaggccg aggccatgcg caagcattac      960
gatgacgtct gggcgccggc gcaatcggaa aagtaccggg tcaaggctaa ctacatcgac     1020
caactggtgg tcatcaccgg cgatagctct accatcgaac caccggccgg ctacaccaag     1080
atcccgtacg acctgaatgc cggtgccggc ggtgacttca tctacctgtg ctatcacgaa     1140
caaacctggc aggccgacag gcctaaagat gctgtgacgg atatcaggat cattttcaac     1200
aaggagccta ccccacctgg ctataccaag ctgccccagg acctgaacaa gggcgcgggc     1260
ggtgatgatg tattcctctg ctacaagacc gaggcttaca acaccgacac cgcaatcaac     1320
aagatcacgg tcatcggcgg caacaatgcg gatatcaacg ctccctatgg ttatctgaag     1380
gtccccggtg acctcaacag aggtgctggc ggcaacttca tctatgcctg taccttcgta     1440
ggcaag                                                                1446

<210>  100
<211>  1449
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  100
atggaaaaca tagacttgcc acaaggactt gtaaactttt ccacgcaaca cctgcaactt       60
attcgtttta aagcaggttt gaatgaaacc gtactacctg gcgtcgaagc cattggactt      120
ggctataacc cattcatcag ttatgccagt gtcaacagcg gcgcggtgca attgttcgac      180
tgggccacgg ccaagaaacg cgaagtgcct ttcaaagccg gctacttcgt acctgagatc      240
gtcgacgtgc aacagaacga cagcgcatcc tacaccaacg tcagcggcaa cacgatcagc      300
gagtaccagc gcagcctggc tgtcagcgtc gccatcgaag gcaaatacaa cttcttcagc      360
ggctctctgt ccacggatta cgacgaaaat tctctgcgca acgcggaaaa cgagttcact      420
cgcattcagc aatctatcaa cctgtggtct ctgcgcctgc cttctgtgaa gtctctgcgc      480
gacctgatgc tgccacacat gcgccaacaa ctagatgaat tgaacgtcaa cgacccgaag      540
gccataagcc gctatttcga tagagttggc agccatttcc ttaccggcat cgtaatgggt      600
ggacgggcca tcctcgcctc ctcgaccaac aagctcaggg tcaagcgtga ctactcggtg      660
tcggtggtcg ccaaggcgag ctacgaaggg cttaccggcc agttgagcgc agaagccaaa      720
gccaagtatg gcgagtcgat cagcagcttc actcagtact ccaataccca ccaggaagtg      780
cgcggcggcg acggtgccaa ggcacatggg gtgttcagcg gcaaaaaaga agatttccag      840
gcctgggtag acagtgtgag cgcctcgccg gacttcgtcg atttcgtccc caccatcccc      900
atgcaggaaa tctggaccct gtgcagcagc gaggcgcagg ccgaggccat gcgcaagcat      960
tacgatgacg tctgggcgcc ggcgcaatcg gaaaagtacc gggtcaaggc taactacatc     1020
gaccaactgg tggtcatcac cggcgatagc tctaccatcg aaccaccggc cggctacacc     1080
aagatcccgt acgacctgaa tgccggtgcc aaaggtgact tcatctacct gtgctatcac     1140
gaacaaacct ggcaggccga caggcctaaa gatgctgtga cggatatcag gatcattttc     1200
aacaaggagc ctaccccacc tggctatacc aagctgcccc aggacctgaa caagggcgcg     1260
ggcggtgatg atgtattcct ctgctacaag accgaggctt acaacaccga caccgcaatc     1320
aacaaggtca cggtcatcgg cggcaacaat gcggatatca acgctcccta tggttatctg     1380
aaggtccccg gtgacctcaa cagaggtgct ggcggcaact tcatctatgc ctgtaccttc     1440
gtaggcaag                                                             1449

<210>  101
<211>  1446
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  101
atggaaaaca tagacttgcc acaaggactt gtaaactttt ccacgcaaca cctgcaactt       60
attcgtttta aagcaggttt gaatgaaacc gtactacctg gcgtcgaagc cattggactt      120
ggctataacc cattcatcag ttatgccagt gtcaacagcg gcgcggtgca attgttcgac      180
tgggccacgg ccaagaaacg cgaagtgcct ttcaaagccg gctacttcgt acccgagatc      240
gtcgacgtgc aacagaacga cagcgcaacc tacaccaacg tcagcggcaa cacgatcacc      300
gagtaccagc gcagcctggc tgtcagcgtc gccatcgaag gccgttacaa cttcttcagt      360
ggctcgctgt ccacggattt cgacagtaat tcactgcgca acgcggaaaa cgagttcact      420
cgcattcagc aatctatcaa cctgtggtct ctgcgcctgc cttctgtgaa gtctctgcgc      480
gacctgatgc tgccacacat gcgcgaacaa ctggatgaac tggacgtcaa aaacccgagc      540
gccatcagcc gctttttcga tcgtgttggc agccatttcc tgaccggcat cgtaatgggt      600
ggacgggcca tcctcgcctc ctcgaccaac aagctcaggg tcaagcgtga ctactcggtg      660
tcggtggtcg ccaaggcgag ctacgaaggg cttaccggcc agttgagcgc agaagccaaa      720
gccaagtatg gcgagtcgat cagcagcttc actcagtact ccaataccca ccaggaagtg      780
cgcggcggcg acggtaccaa ggcacatggt gtgttcgaag gcaaagcagg tttccaggcc      840
tgggtagaca gcgtgggcac ctctccggac ttcgtcgatt tcgtccctac catccctatg      900
ctggaaatct ggtccctgtg caaaaccgac tctcaggccg aggccatgaa acgtcatttc      960
gataccgtct gggcgcgtga gcaatctgac aagtaccgta tcaaggctaa ctacatcgac     1020
caactggtgg tcatcaccgg cgatagctct accatcgaac caccggccgg ctacaccaag     1080
atcccgtacg acctgaatgc cggtgccaaa ggtgacttca tctacctgtg ctatcacgaa     1140
caaacctggc aggccgacag gcctaaagat gctgtgacgg atatcaggat cattttcaac     1200
aaggagccta ccccacctgg ctataccaag ctgccccagg acctgaacaa gggcgcgggc     1260
ggtgatgatg tattcctctg ctacaagacc gaggcttaca acaccgacac cgcaatcaac     1320
aaggtcacgg tcatcggcgg caacaatgcg gatatcaacg ctccttatgg ttatgagaag     1380
gtccctggtg acctgaacaa aggtgctaaa ggcaacttca tctatgcctg taccttcgta     1440
ggcaag                                                                1446

<210>  102
<211>  1446
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  102
atggaaaaca tagacttgcc acaaggactt gtaaactttt ccacgcaaca cctgcaactt       60
attcgtttta aagcaggttt gaatgaaacc gtactacctg gcgtcgaagc cattggactt      120
ggctataacc cattcatcag ttatgccagt gtcaacagcg gcgcggtgca attgttcgac      180
tgggccacgg ccaagaaacg cgaagtgcct ttcaaagccg gctacttcgt acccgagatc      240
gtcgacgtgc aacagaacga cagcgcaacc tacaccaacg tcagcggcaa cacgatcagc      300
gagtaccagc gcagtctggc taccagcgtc gccatcgaag gccgttacaa cttcttcagc      360
ggctctctgt ccacggatta cgacgaaaat tctctgcgca acgcggaaaa cgagttcact      420
cgcattcagc aatctatcaa cctgtggtct ctgcgcctgc cttctgtgaa gtctctgcgc      480
gacctgatgc tgccacacat gcgcgaacaa ctggatgaac tggacgtcaa aaacccgagc      540
gccatcagtc gctttttcga tcgtgttggc agccatttcc tgaccggcat cgtaatgggt      600
ggtcgtgcca tcctggccgc ctctaccaac aagctgaagg tcaagcgtga ctactctgtg      660
tctgtgatcg ccaaggcgag ctacgaaggt ctgaccggcc agctgagcgc agaagcccgt      720
accaagtatg gcgagtctat gagcagcttc actcagtact ccagcaccca ccaggaagtg      780
cgcggcggcg acggtaccaa ggcacatggt gtgttcgaag gcaaagcagg tttccaggcc      840
tgggtagaca gcgtgggcac ctctccggac ttcgtcgatt tcgtccctac catccctatg      900
ctggaaatct ggtccctgtg caaaaccgac tctcaggccg aggccatgaa acgtcatttc      960
gataccgtct gggcgcgtga gcaatctgac aagtaccgta tcaaggctaa ctacatcgac     1020
caactggtgg tcatcaccgg cgatagctct accatcgaac caccggccgg ctacaccaag     1080
atcccgtacg acctgaatgc cagtgccggc ggtgacttca tctacttgtg ctatcacgaa     1140
caaacctggc aggccgacag gcctaaagat gctgtgacgg atatcaggat cattttcaac     1200
aaggagccta ccccacctgg ctataccaag ctgccccagg acctgaacaa gggcgcgggc     1260
ggtgatgatg tattcctctg ctacaagacc gaggcttaca acaccgacac cgcaatcaac     1320
aaggtcacgg tcatcggcgg caacaatgcg gatatcaacg ctccctatgg ttatctgaag     1380
gtccccggtg acctcaacag aggtgctggc ggcaacttca tctatgcctg taccttcgta     1440
ggcaag                                                                1446

<210>  103
<211>  1449
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  103
atggaaaaca tagacttgcc acaaggactt gtaaactttt ccacgcaaca cctgcaactt       60
attcgtttta aagcaggttt gaatgaaacc gtactacctg gcgtcgaagc cattggactt      120
ggctataacc cattcatcag ttatgccagt gtcaacagcg gcgcggtgca attgttcgac      180
tgggccacgg ccaagaaacg cgaagtgcct ttcaaagccg gctacttcgt acccgagatc      240
gtcgacgtgc aacagaacga cagcgcaacc tacaccaacg tcagcggcaa cacgatcagc      300
gagtaccagc gcagtctggc taccagcgtc gccatcgaag gccgttacaa cttcttcagt      360
ggctcgctgt ccacggattt cgacagtaat tcactgcgca acgcggaaaa cgagttcact      420
cgcattcagc aatcgatcaa cctctggtcg ttgcgcttgc cttcggtgaa gtcattgcgc      480
gaactgatgc tgccacacat gcgcgaacaa ctagatgaat tgaacgtcaa cgacccgaag      540
gccataagcc gctatttcga tcgtgttggc agccatttcc ttaccggcat cgtaatgggt      600
ggacgggcca tcctcgcctc ctctaccaac aagctgaagg tcaagcgtga ctactcggtg      660
tcggtggtcg ccaaggcgag ctacgaaggg cttaccggcc agttgagcgc agaagccaaa      720
gccaagtatg gcgagtcgat cagcagcttc actcagtact ccaataccca ccaggaagtg      780
cgcggcggcg acggtgccaa ggcacatggg gtgttcagcg gcaaaaaaga agatttccag      840
gcctgggtag acagtgtgag cgcctcgccg gacttcgtcg atttcgtccc caccatcccc      900
atgcaggaaa tctggaccct gtgcagcagc gaggcgcagg ccgaggccat gcgcaagcat      960
tacgatgacg tctgggcgcc ggcgcaatcg gaaaagtacc gggtcaaggc taactacatc     1020
gaccaactgg tggtcatcac cggcgatagc tctaccatcg aaccaccggc cggctacacc     1080
aagatcccgt acgacctgaa tgccggtgcc ggcggtgact tcatctactt gtgctatcac     1140
gaacaagcct ggtaccctga caacactaaa cctgctgtga cggctatcaa gatcatttac     1200
gaccgtgagc ctgtcccaac tggctatatc aagctgcctc aggacctgaa caagggcgcg     1260
ggcggtgctg atatctacct gtgctacaag ctggagggtt acaacaccga caccgcaatc     1320
aacaagatca cggtcatcag cggcaacaat ccggatatca acgctcctta tggttatgag     1380
aaggtccctg gtgacctgaa caaaggtgct ggcggcaact tcatctatgc ctgtaccttc     1440
gtaggcaag                                                             1449

<210>  104
<211>  1452
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  104
atggaacacg tagacctgcc aacgggtctg gtaaaatttt cctctaatca ccacctgcaa       60
ctgctgcgtg atacggcaga tctgagcgaa tccgtactgc ctggcgtcga agccattgga      120
cttggctata acccattcat cagttatgcc agtgtcaaca gcggcgcggt gcaattgttc      180
gactgggcca cggccaagaa acgcgaagtg cctttcaaag ccggctactt cgtacccgag      240
atcgtcgacg tgcaacagaa cgacagcgca tcctacacca acatcagcgg caacacgatc      300
agcgagtacc agcgcagcct ggctgtcagc gtcgccatcg aaggcaaata caacttcttc      360
agcggctctc tgtccacgga ttacgacgaa aattctctgc gcaacgcgga aaacgagttc      420
actcgcattc agcaatctat caacctgtgg tctctgcgcc tgccttctgt gaagtctctg      480
cgcgacctga tgctgccaca catgcgcgaa caactggatg aactggacgt caaaaacccg      540
agcgccatca gccgcttttt cgatcgtgtt ggcagccatt tcctgaccgg catcgtaatg      600
ggtggtcgtg ccatcctggc cgcctctacc aacaagctga aggtcaagcg tgactactct      660
gtgtctgtga tcgccaaggc gagctacgaa ggtctgaccg gccagctgag cgcagaagcc      720
cgtaccaagt atggcgagtc tatgagcagc ttcactcagt actccagcac ccaccaggaa      780
gtgcgcggcg gcgacggtgc caaggcacat ggggtgttca gcggcaaaaa agaagatttc      840
caggcctggg tagacagtgt gagcgcctcg ccggacttcg tcgatttcgt ccccaccatc      900
cctatgctgg aaatctggtc cctgtgcaaa accgactctc aggccgaggc catgaaacgt      960
catttcgata ccgtctgggc gcgtgagcaa tctgacaagt accgtatcaa ggctaactac     1020
atcgaccaac tggtggtcat caccggcgat agctctacca tcgaaccacc ggccggctac     1080
accaagatcc cgtacgacct gaatgccggt gccaaaggtg acttcatcta cctgtgctat     1140
cacgaacaaa cctggcaggc cgacaggcct aaagatgctg tgacggatat caggatcatt     1200
ttcaacaagg agcctacccc acctggctat accaagctgc cccaggacct gaacaagggc     1260
gcgggcggtg atgatgtatt cctctgctac aagaccgagg cttacaacac cgacaccgca     1320
atcaacaaga tcacggtcat cagcggcaac aatccggata tcaacgctcc ttatggttat     1380
gagaaggtcc ctggtgacct gaacaaaggt gctaaaggca acttcatcta tgcctgtacc     1440
ttcgtaggca ag                                                         1452

<210>  105
<211>  1449
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  105
atggaaaaca tagacttgcc acaaggactt gtaaactttt ccacgcaaca cctgcaactt       60
attcgtttta aagcaggttt gaatgaaacc gtactacctg gcgtcgaagc cattggactt      120
ggctataacc cattcatcag ttatgccagt gtcaacagcg gcgcggtgca attgttcgac      180
tgggccacgg ccaagaaacg cgaagtgcct ttcaaagccg gctacttcgt acccgagatc      240
gtcgacgtgc aacagaacga cagcgcaacc tacaccaacg tcagcggcaa cacgatcagc      300
gagtaccagc gcagtctggc taccagcgtc gccatcgaag gccgttacaa cttcttcagt      360
ggctcgctgt ccacggattt cgacagtaat tcactgcgca acgcggaaaa cgagttcact      420
cgcattcagc aatctatcaa cctgtggtct ctgcgcctgc cttctgtgaa gtctctgcgc      480
gacctgatgc tgccacacat gcgcgaacaa ctagatgaat tgaacgtcaa cgacccgaag      540
gccataagcc gctatttcga tagagttggc agccatttcc ttaccggcat cgtaatgggt      600
ggacgggcca tcctcgcctc ctcgaccaac aagctcaggg tcaagcgtga ctactcggtg      660
tcggtggtcg ccaaggcgag ctacgaaggg cttaccggcc agttgagcgc agaagccaaa      720
gccaagtatg gcgagtcgat cagcagcttc actcagtact ccaataccca ccaggaagtg      780
cgcggcggcg acggtgccaa ggcacatggg gtgttcagcg gcaaaaaaga agatttccag      840
gcctgggtag acagtgtgag cgcctcgccg gacttcgtcg atttcgtccc caccatcccc      900
atgcaggaaa tctggaccct gtgcagcagc gaggcgcagg ccgaggccat gcgcaagcat      960
tacgatgacg tctgggcgcc ggcgcaatcg gaaaagtacc gggtcaaggc taactacatc     1020
gaccaactgg tggtcatcac cggcggtagt tcaaccatcg aaccaccggc cggctacacc     1080
aagatcccgt acgacctgaa tgccggtgcc aaaggtgact tcatctacct gtgctatcac     1140
gaacaagcct ggtaccctga caacactaaa cctgctgtga cggctatcaa gatcatttac     1200
gaccgtgagc ctgtcccaac tggctatatc aagctgcctc aggacctgaa caagggcgcg     1260
ggcggtgctg atatctacct gtgctacaag ctggagggtt acaacaccga caccgcaatc     1320
aacaagatca cggtcatcag cggcaacaat ccggatatca acgctcctta tggttatgag     1380
aaggtccctg gtgacctgaa caaaggtgct aaaggcaact tcatctatgc ctgtaccttc     1440
gtaggcaag                                                             1449

<210>  106
<211>  1452
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  106
atggaacacg tagacctgcc aacgggtctg gtaaaatttt cctctaatca ccacctgcaa       60
ctgctgcgtg atacggcaga tctgagcgaa tccgtactgc ctggcgtcga agccattggt      120
ctgggctata acccattcct gggttatgcc ggtgtcggca gcggcacggt gcaactgttc      180
gactggaaca acgccaagaa aaaaaaagtg tctttcaaac ctgaattcgt cgtacctgag      240
atcgtcgacg tgcaacagaa cgacagcgca tcctacacca acatcagcgg caacacggtc      300
accgagtacc agcgcagcct ggctgtcagc gtcgccatcg aaggcaaata caacttcttc      360
agcggctctc tgtccacgga ttacgacgaa aattctctgc gcaacgcgga aaacgagttc      420
actcgcattc agcaatctat caacctgtgg tctctgcgcc tgccttctgt gaagtctctg      480
cgcgacctga tgctgccaca catgcgccaa caactagatg aattgaacgt caacgacccg      540
aaggccataa gccgctattt cgatagagtt ggcagccatt tccttaccgg catcgtaatg      600
ggtggacggg ccatcctcgc ctcctcgacc aacaagctca gggtcaagcg tgactactcg      660
gtgtcggtgg tcgccaaggc gagctacgaa gggcttaccg gccagttgag cgcagaagcc      720
aaagccaagt atggcgagtc gatcagcagc ttcactcagt actccaatac ccaccaggaa      780
gtgcgcggcg gcgacggtgc caaggcacat ggggtgttca gcggcaaaaa agaagatttc      840
caggcctggg tagacagtgt gagcgcctcg ccggacttcg tcgatttcgt ccctaccatc      900
cctatgctgg aaatctggac cctgtgcagc agcgaggcgc aggccgaggc catgcgcaag      960
cattacgatg acgtctgggc gccggcgcaa tcggaaaagt accgggtcaa ggctaactac     1020
atcgaccaac tggtggtcat caccggcggt agttcaacca tcgaaccacc ggtcggctac     1080
agcaagatcg agtacgacct caatgccggt gccggcggtg acttcatcta cctgtgctat     1140
cacgaacaag cctggtaccc tgacaacact aaacctgctg tgacggctat caagatcatt     1200
tacgaccgtg agcctgtccc aactggctat atcaagctgc ctcaggacct gaacaagggc     1260
gcgggcggtg ctgatatcta cctgtgctac aagctggagg gttacaacac cgacaccgca     1320
atcaacaaga tcatggtcat cagcggcaac aatccggata tcaacgctcc ttatggttat     1380
gagaaggtcc ctggtgacct gaacagaggt gctggcggca acttcatcta tgcctgtacc     1440
ttcgtaggca ag                                                         1452

<210>  107
<211>  1452
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  107
atggaacacg tagacctgcc aacgggtctg gtaaaatttt cctctaatca ccacctgcaa       60
ctgctgcgtg atacggcaga tctgagcgaa tccgtactgc ctggcgtcga agccattggt      120
ctgggctata acccattcct gggttatgcc ggtgtcggca gcggcacggt gcaactgttc      180
gactggaaca acgccaagaa aaaaaaagtg tctttcaaac ctgaattcgt cgtacctgag      240
atcgtcgacg tgcaacagaa cgacagcgca tcctacacca acatcagcgg caacacggtc      300
accgagtacc agcgcagcct ggctgtcagc gtcgccatcg aaggccgtta caacttcttc      360
agtggctcgc tgtccacgga tttcgacagt aattcactgc gcaacgcgga aaacgagttc      420
actcgcattc agcaatcgat caacctctgg tcgttgcgct tgccttcggt gaagtcattg      480
cgcgaactga tgctgccaca catgcgccaa caactagatg aattgaacgt caacgacccg      540
aaggccataa gccgctattt cgatagagtt ggcagccatt tccttaccgg catcgtaatg      600
ggtggacggg ccatcctcgc ctcctcgacc aacaagctga aggtcaagcg tgactactct      660
gtgtctgtga tcgccaaggc gagctacgaa gggcttaccg gccagttgag cgcagaagcc      720
aaagccaagt atggcgagtc gatcagcagc ttcactcagt actccaatac ccaccaggaa      780
gtgcgcggcg gcgacggtgc caaggcacat ggggtgttca gcggcaaaaa agaagatttc      840
caggcctggg tagacagtgt gagcgcctcg ccggacttcg tcgatttcgt ccccaccatc      900
cccatgcagg aaatctggac cctgtgcagc agcgaggcgc aggccgaggc catgcgcaag      960
cattacgatg acgtctgggc gccggcgcaa tcggaaaagt accgggtcaa ggctaactac     1020
atcgaccaac tggtggtcat caccggcgat agctctacca tcgaaccacc ggccggctac     1080
accaagatcc cgtacgacct gaatgccggt gccaaaggtg acttcatcta cctgtgctat     1140
cacgaacaag cctggtaccc tgacaacact aaacctgctg tgacggctat caagatcatt     1200
tacgaccgtg agcctgtccc aactggctat atcaagctgc ctcaggacct gaacaagggc     1260
gcgggcggtg ctgatatcta cctgtgctac aagctggagg gttacaacac cgacaccgca     1320
atcaacaaga tcacggtcat cagcggcaac aatccggata tcaacgctcc ctatggttat     1380
ctgaaggtcc ccggtgacct caacagaggt gctggcggca acttcatcta tgcctgtacc     1440
ttcgtaggca ag                                                         1452

<210>  108
<211>  1446
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  108
atggaaaaca tagacttgcc acaaggactt gtaaactttt ccacgcaaca cctgcaactt       60
attcgtttta aagcaggttt gaatgaaacc gtactacctg gcgtcgaagc cattggactt      120
ggctataacc cattcatcag ttatgccagt gtcaacagcg gcgcggtgca attgttcgac      180
tgggccacgg ccaagaaacg cgaagtgcct ttcaaagccg gctacttcgt acctgagatc      240
gtcgacgtgc aacagaacga cagcgcatcc tacaccaaca tcagcggcaa cacggtcacc      300
gagtaccagc gcagcctggc tgtcagcgtc gccatcgaag gcaaatacaa cttcttcagc      360
ggctctctgt ccacggatta cgacgaaaat tctctgcgca acgcggaaaa cgagttcact      420
cgcattcagc aatctatcaa cctgtggtct ctgcgcctgc cttctgtgaa gtctctgcgc      480
gacctgatgc tgccacacat gcgcgaacaa ctggatgaac tggacgtcaa aaacccgagc      540
gccatcagcc gctttttcga tcgtgttggc agccatttcc ttaccggcat cgtaatgggt      600
ggacgggcca tcctcgcctc ctcgaccaac aagctcaggg tcaagcgtga ctactcggtg      660
tcggtggtcg ccaaggcgag ctacgaaggt ctgaccggcc agctgagcgc agaagcccgt      720
accaagtatg gcgagtctat gagcagcttc actcagtact ccagcaccca ccaggaagtg      780
cgcggcggcg acggtaccaa ggcacatggt gtgttcgaag gcaaagcagg tttccaggcc      840
tgggtagaca gcgtgggcac ctctccggac ttcgtcgatt tcgtccccac catccccatg      900
caggaaatct ggaccctgtg cagcagcgag gcgcaggccg aggccatgcg caagcattac      960
gatgacgtct gggcgccggc gcaatcggaa aagtaccggg tcaaggctaa ctacatcgac     1020
caactggtgg tcatcaccgg cgatagttca accatcgaac caccggtcgg ctacagcaag     1080
atcccgtacg acctgaatgc cggtgccaaa ggtgacttca tctacctgtg ctatcacgaa     1140
caagcctggt accctgacaa cactaaacct gctgtgacgg ctatcaagat catttacgac     1200
cgtgagcctg tcccaactgg ctatatcaag ctgcctcagg acctgaacaa gggcgcgggc     1260
ggtgatgatg tattcctctg ctacaagacc gaggcttaca acaccgacac cgcaatcaac     1320
aaggtcacgg tcatcggcgg caacaatgcg gatatcaacg ctccctatgg ttatctgaag     1380
gtccccggtg acctcaacag aggtgctggc ggcaacttca tctatgcctg taccttcgta     1440
ggcaag                                                                1446

<210>  109
<211>  1449
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  109
atggaaaaca tagacttgcc acaaggactt gtaaactttt ccacgcaaca cctgcaactt       60
attcgtttta aagcaggttt gaatgaaacc gtactacctg gcgtcgaagc cattggactt      120
ggctataacc cattcatcag ttatgccagt gtcaacagcg gcgcggtgca attgttcgac      180
tgggccacgg ccaagaaacg cgaagtgcct ttcaaagccg gctacttcgt acccgagatc      240
gtcgacgtgc aacagaacga cagcgcaacc tacaccaacg tcagcggcaa cacgatcagc      300
gagtaccagc gcagtctggc taccagcgtc gccatcgaag gccgttacaa cttcttcagt      360
ggctcgctgt ccacggatta cgacgaaaat tctctgcgca acgcggaaaa cgagttcact      420
cgcattcagc aatcgatcaa cctctggtcg ttgcgcttgc cttcggtgaa gtcattgcgc      480
gaactgatgc tgccacacat gcgccaacaa ctagatgaat tgaacgtcaa cgacccgaag      540
gccataagcc gctatttcga tagagttggc agccatttcc ttaccggcat cgtaatgggt      600
ggacgggcca tcctcgcctc ctcgaccaac aagctcaggg tcaagcgtga ctactcggtg      660
tcggtggtcg ccaaggcgag ctacgaaggt ctgaccggcc agctgagcgc agaagcccgt      720
accaagtatg gcgagtctat gagcagcttc actcagtact ccagcaccca ccaggaagtg      780
cgcggcggcg acggtgccaa ggcacatggg gtgttcagcg gcaaaaaaga agatttccag      840
gcctgggtag acagcgtggg cacctctccg gacttcgtcg atttcgtccc taccatccct      900
atgctggaaa tctggtccct gtgcaaaacc gactctcagg ccgaggccat gaaacgtcat      960
ttcgataccg tctgggcgcg tgagcaatct gacaagtacc gtatcaaggc taactacatc     1020
gaccaactgg tggtcatcac cggcgatagc tctaccatcg aaccaccggc cggctacacc     1080
aagatcccgt acgacctgaa tgccggtgcc ggcggtgact tcatctacct gtgctatcac     1140
gaacaagcct ggtaccctga caacactaaa cctgctgtga cggctatcaa gatcatttac     1200
gaccgtgagc ctgtcccaac tggctatatc aagctgcctc aggacctgaa caagggcgcg     1260
ggcggtgctg atatctacct gtgctacaag ctggagggtt acaacaccga caccgcaatc     1320
aacaagatca cggtcatcag cggcaacaat ccggatatca acgctcctta tggttatgag     1380
aaggtccctg gtgacctgaa caaaggtgct aaaggcaact tcatctatgc ctgtaccttc     1440
gtaggcaag                                                             1449

<210>  110
<211>  1449
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  110
atggaacacg tagacctgcc aacgggtctg gtaaaatttt cctctaatca ccacctgcaa       60
ctgctgcgtg atacggcaga tctgagcgaa tccgtactgc ctggcgtcga agccattggt      120
ctgggctata acccattcct gggttatgcc ggtgtcggca gcggcacggt gcaactgttc      180
gactggaaca acgccaagaa aaaaaaagtg tctttcaaac ctgaattcgt cgtacctgag      240
atcgtcgacg tgcaacagaa cgacagcgca acctacacca acatcagcgg caacacggtc      300
accgagtacc agcgcagcct ggctgtcagc gtcgccatcg aaggccgtta caacttcttc      360
agcggctctc tgtccacgga ttacgacgaa aattctctgc gcaacgcgga aaacgagttc      420
actcgcattc agcaatcgat caacctctgg tcgttgcgct tgccttcggt gaagtcattg      480
cgcgaactga tgctgccaca catgcgccaa caactagatg aattgaacgt caacgacccg      540
aaggccataa gccgctattt cgatagagtt ggcagccatt tcctgaccgg catcgtaatg      600
ggtggtcgtg ccatcctggc cgcctctacc aacaagctga aggtcaagcg tgactactct      660
gtgtctgtga tcgccaaggc gagctacgaa ggtctgaccg gccagctgag cgcagaagcc      720
cgtaccaagt atggcgagtc tatgagcagc ttcactcagt actccagcac ccaccaggaa      780
gtgcgcggcg gcgacggtac caaggcacat ggtgtgttcg aaggcaaagc aggtttccag      840
gcctgggtag acagcgtgag cgcctcgccg gacttcgtcg atttcgtccc caccatcccc      900
atgcaggaaa tctggaccct gtgcagcagc gaggcgcagg ccgaggccat gcgcaagcat      960
tacgatgacg tctgggcgcc ggcgcaatcg gaaaagtacc gggtcaaggc taactacatc     1020
gaccaactgg tggtcatcac cggcggtagt tcaaccatcg aaccaccggc cggctacacc     1080
aagatcccgt acgacctgaa tgccggtgcc aaaggtgact tcatctacct gtgctatcac     1140
gaacaagcct ggtaccctga caacactaaa cctgctgtga cggctatcaa gatcatttac     1200
gaccgtgagc ctgtcccaac tggctatatc aagctgcctc aggacctgaa caagggcgcg     1260
ggcggtgatg atgtattcct ctgctacaag accgaggctt acaacaccga caccgcaatc     1320
aacaaggtca cggtcatcgg cggcaacaat gcggatatca acgctcccta tggttatctg     1380
aaggtccccg gtgacctcaa cagaggtgct ggcggcaact tcatctatgc ctgtaccttc     1440
gtaggcaag                                                             1449

<210>  111
<211>  1449
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  111
atggaaaaca tagacttgcc acaaggactt gtaaactttt ccacgcaaca cctgcaactt       60
attcgtttta aagcaggttt gaatgaaacc gtactacctg gcgtcgaagc cattggactt      120
ggctataacc cattcatcag ttatgccagt gtcaacagcg gcgcggtgca attgttcgac      180
tgggccacgg ccaagaaacg cgaagtgcct ttcaaagccg gctacttcgt acccgagatc      240
gtcgacgtgc aacagaacga cagcgcaacc tacaccaacg tcagcggcaa cacgatcagc      300
gagtaccagc gcagtctggc taccagcgtc gccatcgaag gccgttacaa cttcttcagt      360
ggctcgctgt ccacggattt cgacagtaat tcactgcgca acgcggaaaa cgagttcact      420
cgcattcagc aatctatcaa cctgtggtct ctgcgcctgc cttctgtgaa gtctctgcgc      480
gacctgatgc tgccacacat gcgcgaacaa ctggatgaac tggacgtcaa aaacccgagc      540
gccatcagcc gctttttcga tcgtgttggc agccatttcc tgaccggcat cgtaatgggt      600
ggtcgtgcca tcctggccgc ctctaccaac aagctgaagg tcaagcgtga ctactctgtg      660
tctgtgatcg ccaaggcgag ctacgaaggt ctgaccggcc agttgagcgc agaagccaaa      720
gccaagtatg gcgagtcgat cagcagcttc actcagtact ccagcaccca ccaggaagtg      780
cgcggcggcg acggtgccaa ggcacatggg gtgttcagcg gcaaaaaaga agatttccag      840
gcctgggtag acagtgtgag cgcctcgccg gacttcgtcg atttcgtccc caccatcccc      900
atgcaggaaa tctggaccct gtgcagcagc gaggcgcagg ccgaggccat gcgcaagcat      960
tacgatgacg tctgggcgcc gacgcaatcg gaaaagtacc gggtcaaggc taactacatc     1020
gaccaactgg tggtcatcac cggcggtagt tcaaccatcg aaccaccggt cggctacagc     1080
aagatcgagt acgacctgaa tgccggtgcc aaaggtgact tcatctacct gtgctatcac     1140
gaacaagcct ggtaccctga caacactaaa cctgctgtga cggctatcaa gatcatttac     1200
gaccgtgagc ctgtcccaac tggctatatc aagctgcctc aggacctgaa caagggcgcg     1260
ggcggtgctg atatctacct gtgctacaag ctggagggtt acaacaccga caccgcaatc     1320
aacaagatca cggtcatcag cggcaacaat ccggatatca acgctcctta tggttatgag     1380
aaggtccctg gtgacctgaa caaaggtgct aaaggcaact tcatctatgc ctgtaccttc     1440
gtaggcaag                                                             1449

<210>  112
<211>  1449
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  112
atggaaaaca tagacttgcc acaaggactt gtaaactttt ccacgcaaca cctgcaactt       60
attcgtttta aagcaggttt gaatgaaacc gtactacctg gcgtcgaagc cattggactt      120
ggctataacc cattcatcag ttatgccagt gtcaacagcg gcgcggtgca attgttcgac      180
tgggccacgg ccaagaaacg cgaagtgcct ttcaaagccg gctacttcgt acccgagatc      240
gtcgacgtgc aacagaacga cagcgcatcc tacaccaaca tcagcggcaa cacggtcacc      300
gagtaccagc gcagcctggc tgtcagcgtc gccatcgaag gcaaatacaa cttcttcagc      360
ggctctctgt ccacggatta cgacgaaaat tctctgcgca acgcggaaaa cgagttcact      420
cgcattcagc aatctatcaa cctgtggtct ctgcgcctgc cttctgtgaa gtctctgcgc      480
gacctgatgc tgccacacat gcgcgaacaa ctggatgaac tggacgtcaa aaacccgagc      540
gccatcagcc gctttttcga tcgtgttggc agccatttcc tgaccggcat cgtaatgggt      600
ggtcgtgcca tcctggccgc ctctaccaac aagctgaagg tcaagcgtga ctactctgtg      660
tctgtgatcg ccaaggcgag ctacgaaggt ctgaccgggc agctgagcgc agaagccaaa      720
gccaagtatg gcgagtcgat cagcagcttc actcagtact ccaataccca ccaggaagtg      780
cgcggcggcg acggtgccaa ggcacatggg gtgttcagcg gcaaaaaaga agatttccag      840
gcctgggtag acagtgtgag cgcctcgccg gacttcgtcg atttcgtccc caccatcccc      900
atgcaggaaa tctggaccct gtgcagcagc gaggcgcagg ccgaggccat gcgcaagcat      960
tacgatgacg tctgggcgcc ggcgcaatcg gaaaagtacc gggtcaaggc taactacatc     1020
gaccaactgg tggtcatcac cggcggtagt tcaaccatcg aaccaccggc cggctacacc     1080
aagatcccgt acgacctgaa tgccggtgcc aaaggtgact tcatctacct gtgctatcac     1140
gaacaaacct ggcaggccga caggcctaaa gatgttgtga cggatatcag gatcattttc     1200
aacaaggagc ctaccccacc tggctatacc aagctgcccc aggacctgaa caagggcgcg     1260
ggcggtgatg atgtattcct ctgctacaag accgaggctt acaacaccga caccgcaatc     1320
aacaaggtca cggtcatcgg cggcaacaat gcggatatca acgctcccta tggttatctg     1380
aaggtccccg gtgacctcaa cagaggtgct ggcggcaact tcatctatgc ctgtaccttc     1440
gtaggcaag                                                             1449

<210>  113
<211>  1449
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  113
atggaacacg tagacctgcc aacgggtctg gtaaaatttt cctctaatca ccacctgcaa       60
ctgctgcgtg atacggcaga tctgagcgaa tccgtactgc ctggcgtcga agccattggt      120
ctgggctata acccattcct gggttatgcc ggtgtcggca gcggcacggt gcaactgttc      180
gactggaaca acgccaagaa aaaaaaagtg tctttcaaac ctgaattcgt cgtacctgag      240
atcgtcgacg tgcaacagaa cgacagcgca tcctacacca acatcagcgg caacacggtc      300
accgagtacc agcgcagcct ggctgtcagc gtcgccatcg aaggcaaata caacttcttc      360
agcggctctc tgtccacgga ttacgacgaa aattctctgc gcaacgcgga aaacgagttc      420
actcgcattc agcaatctat caacctgtgg tctctgcgcc tgccttctgt gaagtctctg      480
cgcgacctga tgctgccaca catgcgcgaa caactggatg aactggacgt caaaaacccg      540
agcgccatca gccgcttttt cgatcgtgtt ggcagccatt tcctgaccgg catcgtaatg      600
ggtggtcgtg ccatcctggc cgcctctacc aacaagctga aggtcaagcg tgactactcg      660
gtgtcggtgg tcgccaaggc gagctacgaa ggtctgaccg gccagctgag cgcagaagcc      720
cgtaccaagt atggcgagtc tatgagcagc ttcactcagt actccagcac ccaccaggaa      780
gtgcgcggcg gcgacggtac caaggcacat ggtgtgttcg aaggcaaagc aggtttccag      840
gcctgggtag acagtgtgag cgcctcgccg gacttcgtcg atttcgtccc caccatcccc      900
atgcaggaaa tctggaccct gtgcaaaacc gactctcagg ccgaggccat gcgcaagcat      960
tacgatgacg tctgggcgcg tgagcaatct gacaagtacc gtatcaaggc taactacatc     1020
gaccaactgg tggtcatcac cggcggtagt tcaaccatcg aaccaccggt cggctacagc     1080
aagatcgagt acgacctcaa tgccggtgcc ggcggtgact tcatctactt gtgctatcac     1140
gaacaaacct ggcaggccga caggcctaaa gatgctgtga cggatatcag gatcattttc     1200
aacaaggagc ctaccccacc tggctatacc aagctgcccc aggacctgaa caagggcgcg     1260
ggcggtgatg atgtattcct ctgctacaag accgaggctt acaacaccga caccgcaatc     1320
aacaaggtca cggtcatcgg cggcaacaat gcggatatca acgctcccta tggttatctg     1380
aaggtccccg gtgacctcaa cagaggtgct ggcggcaact tcatctatgc ctgtaccttc     1440
gtaggcaag                                                             1449

<210>  114
<211>  484
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  114
Met Glu His Val Asp Leu Pro Thr Gly Leu Val Lys Phe Ser Ser Asn 
1               5                   10                  15      
His His Leu Gln Leu Leu Arg Asp Thr Ala Asp Leu Ser Glu Ser Val 
            20                  25                  30          
Leu Pro Gly Val Glu Ala Ile Gly Leu Gly Tyr Asn Pro Phe Leu Gly 
        35                  40                  45              
Tyr Ala Gly Val Gly Ser Gly Thr Val Gln Leu Phe Asp Trp Asn Asn 
    50                  55                  60                  
Ala Lys Lys Lys Lys Val Ser Phe Lys Pro Glu Phe Val Val Pro Glu 
65                  70                  75                  80  
Ile Val Asp Val Gln Gln Asn Asp Ser Ala Ser Tyr Thr Asn Ile Ser 
                85                  90                  95      
Gly Asn Thr Val Thr Glu Tyr Gln Arg Ser Leu Ala Val Ser Val Ala 
            100                 105                 110         
Ile Glu Gly Lys Tyr Asn Phe Phe Ser Gly Ser Leu Ser Thr Asp Tyr 
        115                 120                 125             
Asp Glu Asn Ser Leu Arg Asn Ala Glu Asn Glu Phe Thr Arg Ile Gln 
    130                 135                 140                 
Gln Ser Ile Asn Leu Trp Ser Leu Arg Leu Pro Ser Val Lys Ser Leu 
145                 150                 155                 160 
Arg Asp Leu Met Leu Pro His Met Arg Glu Gln Leu Asp Glu Leu Asp 
                165                 170                 175     
Val Lys Asn Pro Ser Ala Ile Ser Arg Phe Phe Asp Arg Val Gly Ser 
            180                 185                 190         
His Phe Leu Thr Gly Ile Val Met Gly Gly Arg Ala Ile Leu Ala Ala 
        195                 200                 205             
Ser Thr Asn Lys Leu Lys Val Lys Arg Asp Tyr Ser Val Ser Val Ile 
    210                 215                 220                 
Ala Lys Ala Ser Tyr Glu Gly Leu Thr Gly Gln Leu Ser Ala Glu Ala 
225                 230                 235                 240 
Lys Ala Lys Tyr Gly Glu Ser Ile Ser Ser Phe Thr Gln Tyr Ser Asn 
                245                 250                 255     
Thr His Gln Glu Val Arg Gly Gly Asp Gly Ala Lys Ala His Gly Val 
            260                 265                 270         
Phe Ser Gly Lys Lys Glu Asp Phe Gln Ala Trp Val Asp Ser Val Ser 
        275                 280                 285             
Ala Ser Pro Asp Phe Val Asp Phe Val Pro Thr Ile Pro Met Gln Glu 
    290                 295                 300                 
Ile Trp Thr Leu Cys Ser Ser Glu Ala Gln Ala Glu Ala Met Arg Lys 
305                 310                 315                 320 
His Tyr Asp Asp Val Trp Ala Pro Ala Gln Ser Glu Lys Tyr Arg Val 
                325                 330                 335     
Lys Ala Asn Tyr Ile Asp Gln Leu Val Val Ile Thr Gly Gly Ser Ser 
            340                 345                 350         
Thr Ile Glu Pro Pro Val Gly Tyr Ser Lys Ile Glu Tyr Asp Leu Asn 
        355                 360                 365             
Ala Gly Ala Gly Gly Asp Phe Ile Tyr Leu Cys Tyr His Glu Gln Thr 
    370                 375                 380                 
Trp Gln Ala Asp Arg Pro Lys Asp Ala Val Thr Asp Ile Arg Ile Ile 
385                 390                 395                 400 
Phe Asn Lys Glu Pro Thr Pro Pro Gly Tyr Thr Lys Leu Pro Gln Asp 
                405                 410                 415     
Leu Asn Lys Gly Ala Gly Gly Asp Asp Val Phe Leu Cys Tyr Lys Thr 
            420                 425                 430         
Glu Ala Tyr Asn Thr Asp Thr Ala Ile Asn Lys Val Thr Val Ile Gly 
        435                 440                 445             
Gly Asn Asn Ala Asp Ile Asn Ala Pro Tyr Gly Tyr Leu Lys Val Pro 
    450                 455                 460                 
Asp Asp Leu Asn Arg Gly Ala Gly Gly Asn Phe Ile Tyr Ala Cys Thr 
465                 470                 475                 480 
Phe Val Gly Lys 
                

<210>  115
<211>  483
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  115
Met Glu His Val Asp Leu Pro Thr Gly Leu Val Lys Phe Ser Ser Asn 
1               5                   10                  15      
His His Leu Gln Leu Leu Arg Asp Thr Ala Asp Leu Ser Glu Ser Val 
            20                  25                  30          
Leu Pro Gly Val Glu Ala Ile Gly Leu Gly Tyr Asn Pro Phe Leu Gly 
        35                  40                  45              
Tyr Ala Gly Val Gly Ser Gly Thr Val Gln Leu Phe Asp Trp Asn Asn 
    50                  55                  60                  
Ala Lys Lys Lys Lys Val Ser Phe Lys Pro Glu Phe Val Val Pro Glu 
65                  70                  75                  80  
Ile Val Asp Val Gln Gln Asn Asp Ser Ala Ser Tyr Thr Asn Ile Ser 
                85                  90                  95      
Gly Asn Thr Val Thr Glu Tyr Gln Arg Ser Leu Ala Val Ser Val Ala 
            100                 105                 110         
Ile Glu Gly Lys Tyr Asn Phe Phe Ser Gly Ser Leu Ser Thr Asp Tyr 
        115                 120                 125             
Asp Glu Asn Ser Leu Arg Asn Ala Glu Asn Glu Phe Thr Arg Ile Gln 
    130                 135                 140                 
Gln Ser Ile Asn Leu Trp Ser Leu Arg Leu Pro Ser Val Lys Ser Leu 
145                 150                 155                 160 
Arg Asp Leu Met Leu Pro His Met Arg Glu Gln Leu Asp Glu Leu Asp 
                165                 170                 175     
Val Lys Asn Pro Ser Ala Ile Ser Arg Phe Phe Asp Arg Val Gly Ser 
            180                 185                 190         
His Phe Leu Thr Gly Ile Val Met Gly Gly Arg Ala Ile Leu Ala Ala 
        195                 200                 205             
Ser Thr Asn Lys Leu Lys Val Lys Leu Asp Tyr Ser Val Ser Val Ile 
    210                 215                 220                 
Ala Lys Ala Ser Tyr Glu Gly Leu Thr Gly Gln Leu Ser Ala Glu Ala 
225                 230                 235                 240 
Arg Thr Lys Tyr Gly Glu Ser Met Ser Ser Phe Thr His Tyr Ser Ser 
                245                 250                 255     
Thr His Gln Glu Val Arg Gly Gly Asp Gly Thr Lys Ala His Gly Val 
            260                 265                 270         
Phe Glu Gly Lys Ala Gly Phe Gln Ala Trp Val Asp Ser Val Gly Thr 
        275                 280                 285             
Ser Pro Asp Phe Val Asp Phe Val Pro Thr Ile Pro Met Leu Glu Ile 
    290                 295                 300                 
Trp Ser Leu Cys Lys Thr Asp Ser Gln Ala Glu Ala Met Lys Arg His 
305                 310                 315                 320 
Phe Asp Thr Val Trp Ala Arg Glu Gln Ser Asp Lys Tyr Arg Ile Lys 
                325                 330                 335     
Ala Asn Tyr Ile Asp Gln Leu Val Val Ile Thr Gly Asp Ser Ser Thr 
            340                 345                 350         
Ile Glu Pro Pro Ala Gly Tyr Thr Lys Ile Pro Tyr Asp Leu Asn Ala 
        355                 360                 365             
Gly Ala Lys Gly Asp Phe Ile Tyr Leu Cys Tyr His Glu Gln Thr Trp 
    370                 375                 380                 
Gln Ala Asp Arg Pro Lys Asp Ala Val Thr Asp Ile Arg Ile Ile Phe 
385                 390                 395                 400 
Asn Lys Glu Pro Thr Pro Pro Gly Tyr Thr Lys Leu Pro Gln Asp Leu 
                405                 410                 415     
Asn Lys Gly Ala Gly Gly Asp Asp Val Phe Leu Cys Tyr Lys Thr Glu 
            420                 425                 430         
Ala Tyr Asn Thr Asp Thr Ala Ile Asn Lys Val Thr Val Ile Gly Gly 
        435                 440                 445             
Asn Asn Ala Asp Ile Asn Ala Pro Tyr Gly Tyr Leu Lys Val Pro Gly 
    450                 455                 460                 
Asp Leu Asn Arg Gly Ala Gly Gly Asn Phe Ile Tyr Ala Cys Thr Phe 
465                 470                 475                 480 
Val Gly Lys 
            

<210>  116
<211>  484
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  116
Met Glu His Val Asp Leu Pro Thr Gly Leu Val Lys Phe Ser Ser Asn 
1               5                   10                  15      
His His Leu Gln Leu Leu Arg Asp Thr Ala Asp Leu Ser Glu Ser Val 
            20                  25                  30          
Leu Pro Gly Val Glu Ala Ile Gly Leu Gly Tyr Asn Pro Phe Leu Gly 
        35                  40                  45              
Tyr Ala Gly Val Gly Ser Gly Thr Val Gln Leu Phe Asp Trp Asn Asn 
    50                  55                  60                  
Ala Lys Lys Lys Lys Val Ser Phe Lys Pro Glu Phe Val Val Pro Glu 
65                  70                  75                  80  
Ile Val Asp Val Gln Gln Asn Asp Ser Ala Ser Tyr Thr Asn Ile Ser 
                85                  90                  95      
Gly Asn Thr Phe Thr Glu Tyr Gln Arg Ser Leu Ala Val Ser Val Ala 
            100                 105                 110         
Ile Glu Gly Lys Tyr Asn Phe Phe Ser Gly Ser Leu Ser Thr Asp Tyr 
        115                 120                 125             
Asp Glu Asn Ser Leu Arg Asn Ala Glu Asn Glu Phe Thr Arg Ile Gln 
    130                 135                 140                 
Gln Ser Ile Asn Leu Trp Ser Leu Arg Leu Pro Ser Val Lys Ser Leu 
145                 150                 155                 160 
Arg Asp Leu Met Leu Pro His Met Arg Glu Gln Leu Asp Glu Leu Asp 
                165                 170                 175     
Val Lys Asn Pro Ser Ala Ile Ser Arg Phe Phe Asp Arg Val Gly Ser 
            180                 185                 190         
His Phe Leu Thr Gly Ile Val Met Gly Gly Arg Ala Ile Leu Ala Ala 
        195                 200                 205             
Ser Thr Asn Lys Leu Lys Val Lys Arg Asp Tyr Ser Val Ser Val Ile 
    210                 215                 220                 
Ala Lys Ala Ser Tyr Glu Gly Leu Thr Gly Gln Leu Ser Ala Glu Ala 
225                 230                 235                 240 
Arg Asn Lys Tyr Gly Glu Ser Met Ser Ser Phe Thr Gln Tyr Ser Ser 
                245                 250                 255     
Thr His Gln Glu Val Arg Gly Gly Asp Gly Ala Lys Ala His Gly Val 
            260                 265                 270         
Phe Ser Gly Lys Lys Glu Asp Phe Gln Ala Trp Val Asp Ser Val Ser 
        275                 280                 285             
Ala Ser Pro Asp Phe Val Asp Phe Val Pro Thr Ile Pro Met Gln Glu 
    290                 295                 300                 
Ile Trp Thr Leu Cys Ser Ser Glu Ala Gln Ala Glu Ala Met Arg Lys 
305                 310                 315                 320 
His Tyr Asp Asp Val Trp Ala Pro Ala Gln Ser Glu Lys Tyr Arg Val 
                325                 330                 335     
Lys Ala Asn Tyr Ile Asp Gln Leu Val Val Ile Thr Gly Gly Ser Ser 
            340                 345                 350         
Thr Ile Glu Pro Pro Val Gly Tyr Ser Lys Ile Glu Tyr Asp Leu Asn 
        355                 360                 365             
Ala Gly Ala Gly Gly Asp Phe Ile Tyr Leu Cys Tyr His Glu Gln Thr 
    370                 375                 380                 
Trp Gln Ala Asp Arg Pro Lys Asp Ala Val Thr Asp Ile Arg Ile Ile 
385                 390                 395                 400 
Phe Asn Lys Glu Pro Thr Pro Pro Gly Tyr Thr Lys Leu Pro Gln Asp 
                405                 410                 415     
Leu Asn Lys Gly Ala Gly Gly Asp Asp Val Phe Leu Cys Tyr Lys Thr 
            420                 425                 430         
Glu Ala Tyr Asn Thr Asp Thr Ala Ile Asn Lys Val Thr Val Ile Gly 
        435                 440                 445             
Gly Asn Asn Ala Asp Ile Asn Ala Pro Tyr Gly Tyr Leu Lys Val Pro 
    450                 455                 460                 
Gly Asp Leu Asn Arg Gly Ala Gly Gly Asn Phe Ile Tyr Ala Cys Thr 
465                 470                 475                 480 
Phe Val Gly Lys 
                

<210>  117
<211>  483
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  117
Met Glu His Val Asp Leu Pro Thr Gly Leu Val Lys Phe Ser Ser Asn 
1               5                   10                  15      
His His Leu Gln Leu Leu Arg Asp Thr Ala Asp Leu Ser Glu Ser Val 
            20                  25                  30          
Leu Pro Gly Val Glu Ala Ile Gly Leu Gly Tyr Asn Pro Phe Leu Gly 
        35                  40                  45              
Tyr Ala Gly Val Gly Ser Gly Thr Val Gln Leu Phe Asp Trp Asn Asn 
    50                  55                  60                  
Ala Lys Lys Lys Lys Val Ser Phe Lys Pro Glu Phe Val Val Pro Glu 
65                  70                  75                  80  
Ile Val Asp Val Gln Gln Asn Asp Ser Ala Ser Tyr Thr Asn Ile Ser 
                85                  90                  95      
Gly Asn Thr Val Thr Glu Tyr Gln Arg Ser Leu Ala Val Ser Val Ala 
            100                 105                 110         
Ile Glu Gly Lys Tyr Asn Phe Phe Ser Gly Ser Leu Ser Thr Asp Tyr 
        115                 120                 125             
Asp Glu Asn Ser Leu Arg Asn Ala Glu Asn Glu Phe Thr Arg Ile Gln 
    130                 135                 140                 
Gln Ser Ile Asn Leu Trp Ser Leu Arg Leu Pro Ser Val Lys Ser Leu 
145                 150                 155                 160 
Arg Glu Leu Met Leu Pro His Met Arg Glu Gln Leu Asp Glu Leu Asp 
                165                 170                 175     
Val Lys Asn Pro Ser Ala Ile Ser Arg Phe Phe Asp Arg Val Gly Ser 
            180                 185                 190         
His Phe Leu Thr Gly Ile Val Met Gly Gly Arg Ala Ile Leu Ala Ala 
        195                 200                 205             
Ser Thr Asn Lys Leu Arg Val Lys Arg Asp Tyr Ser Val Ser Val Ile 
    210                 215                 220                 
Ala Lys Ala Ser Tyr Glu Gly Leu Thr Gly Gln Leu Ser Ala Glu Ala 
225                 230                 235                 240 
Lys Ala Lys Tyr Gly Glu Ser Met Ser Ser Phe Thr Gln Tyr Ser Ser 
                245                 250                 255     
Thr His Gln Glu Val Arg Gly Gly Asp Gly Thr Lys Ala His Gly Val 
            260                 265                 270         
Phe Glu Gly Lys Ala Gly Phe Gln Ala Trp Val Asp Ser Val Gly Thr 
        275                 280                 285             
Ser Pro Asp Phe Val Asp Phe Val Pro Thr Ile Pro Met Leu Glu Ile 
    290                 295                 300                 
Trp Ser Leu Cys Lys Thr Asp Ser Gln Ala Glu Ala Met Lys Arg His 
305                 310                 315                 320 
Phe Asp Thr Val Trp Ala Arg Glu Gln Ser Asp Lys Tyr Arg Ile Lys 
                325                 330                 335     
Ala Asn Tyr Ile Asp Gln Leu Val Val Ile Thr Gly Asp Ser Ser Thr 
            340                 345                 350         
Ile Glu Pro Pro Ala Gly Tyr Thr Lys Ile Pro Tyr Asp Leu Asn Ala 
        355                 360                 365             
Gly Ala Lys Gly Asp Phe Ile Tyr Leu Cys Tyr His Glu Gln Ala Trp 
    370                 375                 380                 
Tyr Pro Asp Asn Thr Lys Pro Ala Val Thr Ala Ile Lys Ile Ile Tyr 
385                 390                 395                 400 
Asp Arg Glu Pro Val Pro Thr Gly Tyr Ile Lys Leu Pro Gln Asp Leu 
                405                 410                 415     
Asn Lys Gly Ala Gly Gly Ala Asp Ile Tyr Leu Cys Tyr Lys Leu Glu 
            420                 425                 430         
Gly Tyr Asn Thr Asp Thr Ala Ile Asn Lys Ile Thr Val Ile Ser Gly 
        435                 440                 445             
Asn Asn Pro Asp Ile Asn Ala Pro Tyr Gly Tyr Glu Lys Val Pro Gly 
    450                 455                 460                 
Asp Leu Asn Lys Gly Ala Lys Gly Asn Phe Ile Tyr Ala Cys Thr Phe 
465                 470                 475                 480 
Val Gly Lys 
            

<210>  118
<211>  483
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  118
Met Glu His Val Asp Leu Pro Thr Gly Leu Val Lys Phe Ser Ser Asn 
1               5                   10                  15      
His His Leu Gln Leu Leu Arg Asp Thr Ala Asp Leu Ser Glu Ser Val 
            20                  25                  30          
Leu Pro Gly Val Glu Ala Ile Gly Leu Gly Tyr Asn Pro Phe Leu Gly 
        35                  40                  45              
Tyr Ala Gly Val Gly Ser Gly Thr Val Gln Leu Phe Asp Trp Asn Asn 
    50                  55                  60                  
Ala Lys Lys Lys Lys Val Ser Phe Lys Pro Glu Phe Val Val Pro Glu 
65                  70                  75                  80  
Ile Val Asp Val Gln Gln Asn Asp Ser Ala Ser Tyr Thr Asn Ile Ser 
                85                  90                  95      
Gly Asn Thr Val Thr Glu Tyr Gln Arg Ser Leu Ala Val Ser Val Ala 
            100                 105                 110         
Ile Glu Gly Lys Tyr Asn Phe Phe Ser Gly Ser Leu Ser Thr Asp Tyr 
        115                 120                 125             
Asp Glu Asn Ser Leu Arg Asn Ala Glu Asn Glu Phe Thr Arg Ile Gln 
    130                 135                 140                 
Gln Ser Ile Asn Leu Trp Ser Leu Arg Leu Pro Ser Val Lys Ser Leu 
145                 150                 155                 160 
Arg Asp Leu Met Leu Pro His Met Arg Glu Gln Leu Asp Glu Leu Asp 
                165                 170                 175     
Val Lys Asn Pro Ser Ala Ile Ser Arg Phe Phe Asp Arg Val Gly Ser 
            180                 185                 190         
His Phe Leu Thr Gly Ile Val Met Gly Gly Arg Ala Ile Leu Ala Ala 
        195                 200                 205             
Ser Thr Asn Lys Leu Lys Val Lys Arg Asp Tyr Ser Val Ser Val Ile 
    210                 215                 220                 
Ala Lys Ala Ser Tyr Glu Gly Leu Thr Gly Gln Leu Ser Ala Glu Ala 
225                 230                 235                 240 
Arg Thr Lys Tyr Gly Glu Ser Met Ser Ser Phe Thr Gln Tyr Ser Ser 
                245                 250                 255     
Thr His Gln Glu Val Arg Gly Gly Asp Gly Thr Lys Ala His Gly Val 
            260                 265                 270         
Phe Glu Gly Lys Ala Gly Phe Gln Ala Trp Val Asp Ser Val Gly Thr 
        275                 280                 285             
Ser Pro Asp Phe Val Asp Phe Val Pro Thr Ile Pro Met Leu Glu Ile 
    290                 295                 300                 
Trp Ser Leu Cys Lys Thr Asp Ser Gln Ala Glu Ala Met Lys Arg His 
305                 310                 315                 320 
Phe Asp Thr Val Trp Ala Ser Glu Gln Ser Asp Lys Tyr Arg Ile Lys 
                325                 330                 335     
Ala Asn Tyr Ile Asp Gln Leu Val Val Ile Thr Gly Asp Ser Ser Thr 
            340                 345                 350         
Ile Glu Pro Pro Ala Gly Tyr Thr Lys Ile Pro Tyr Asp Leu Asn Ala 
        355                 360                 365             
Gly Ala Lys Gly Asp Phe Ile Tyr Leu Cys Tyr His Glu Gln Ala Trp 
    370                 375                 380                 
Tyr Pro Asp Asn Thr Lys Pro Ala Val Thr Ala Ile Lys Ile Ile Tyr 
385                 390                 395                 400 
Asp Arg Glu Pro Val Pro Thr Gly Tyr Ile Lys Leu Pro Gln Asp Leu 
                405                 410                 415     
Asn Lys Gly Ala Gly Gly Asp Asp Val Phe Leu Cys Tyr Lys Thr Glu 
            420                 425                 430         
Ala Tyr Asn Thr Asp Thr Ala Ile Asn Lys Val Thr Val Ile Gly Gly 
        435                 440                 445             
Asn Asn Ala Asp Ile Asn Ala Pro Tyr Gly Tyr Leu Lys Val Pro Gly 
    450                 455                 460                 
Asp Leu Asn Arg Gly Ala Gly Gly Asn Phe Ile Tyr Ala Cys Thr Phe 
465                 470                 475                 480 
Val Gly Lys 
            

<210>  119
<211>  484
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  119
Met Glu His Val Asp Leu Pro Thr Gly Leu Val Lys Phe Ser Ser Asn 
1               5                   10                  15      
His His Leu Gln Leu Leu Arg Asp Thr Ala Asp Leu Ser Glu Ser Val 
            20                  25                  30          
Leu Pro Gly Val Glu Ala Ile Gly Leu Gly Tyr Asn Pro Phe Leu Gly 
        35                  40                  45              
Tyr Ala Gly Val Gly Ser Gly Thr Val Gln Leu Phe Asp Trp Asn Asn 
    50                  55                  60                  
Ala Lys Lys Lys Lys Val Ser Phe Lys Pro Glu Phe Val Val Pro Glu 
65                  70                  75                  80  
Ile Val Asp Val Gln Gln Asn Asp Ser Ala Ser Tyr Thr Asn Ile Ser 
                85                  90                  95      
Gly Asn Thr Val Thr Glu Tyr Gln Arg Ser Leu Ala Val Ser Val Ala 
            100                 105                 110         
Ile Glu Gly Lys Tyr Asn Phe Phe Ser Gly Ser Leu Ser Thr Asp Tyr 
        115                 120                 125             
Tyr Glu Asn Ser Leu Arg Asn Ala Glu Asn Glu Phe Thr Arg Ile Gln 
    130                 135                 140                 
Gln Ser Ile Asn Leu Trp Ser Leu Arg Leu Pro Ser Val Lys Ser Leu 
145                 150                 155                 160 
Arg Asp Leu Met Leu Pro His Met Arg Glu Gln Leu Asp Glu Leu Asp 
                165                 170                 175     
Val Lys Asn Pro Ser Ala Ile Ser Arg Phe Phe Asp Arg Val Gly Ser 
            180                 185                 190         
His Phe Leu Thr Gly Ile Val Met Gly Gly Arg Ala Ile Ile Ala Ser 
        195                 200                 205             
Ser Thr Asn Lys Leu Arg Val Lys Arg Asp Tyr Ser Val Ser Val Val 
    210                 215                 220                 
Ala Lys Ala Ser Tyr Glu Gly Leu Thr Gly Gln Leu Ser Ala Glu Ala 
225                 230                 235                 240 
Lys Ala Lys Tyr Gly Glu Ser Ile Ser Ser Phe Thr Gln Tyr Ser Asn 
                245                 250                 255     
Thr His Gln Glu Val Arg Gly Gly Asp Gly Ala Lys Ala His Gly Val 
            260                 265                 270         
Phe Ser Gly Lys Lys Glu Asp Phe Gln Ala Trp Val Asp Ser Val Ser 
        275                 280                 285             
Ala Ser Pro Asp Phe Val Asp Phe Val Pro Thr Ile Pro Met Gln Glu 
    290                 295                 300                 
Ile Trp Thr Leu Cys Lys Thr Asp Ser Gln Ala Glu Ala Met Lys Arg 
305                 310                 315                 320 
His Phe Asp Thr Val Trp Ala Arg Glu Gln Ser Asp Lys Tyr Arg Ile 
                325                 330                 335     
Lys Ala Asn Tyr Ile Asp Gln Leu Val Val Ile Thr Gly Asp Ser Ser 
            340                 345                 350         
Thr Ile Glu Pro Pro Ala Gly Tyr Thr Lys Ile Pro Tyr Asp Leu Asn 
        355                 360                 365             
Ala Gly Ala Lys Gly Asp Phe Ile Tyr Leu Cys Tyr His Glu Gln Ala 
    370                 375                 380                 
Trp Tyr Pro Asp Asn Thr Lys Pro Ala Val Thr Ala Ile Lys Ile Ile 
385                 390                 395                 400 
Tyr Asp Arg Glu Pro Val Pro Thr Gly Tyr Ile Lys Leu Pro Gln Asp 
                405                 410                 415     
Leu Asn Lys Gly Ala Gly Gly Ala Asp Ile Tyr Leu Cys Tyr Lys Leu 
            420                 425                 430         
Glu Gly Tyr Asn Thr Asp Thr Ala Ile Asn Lys Ile Thr Val Ile Ser 
        435                 440                 445             
Gly Asn Asn Pro Asp Ile Asn Ala Pro Tyr Gly Tyr Glu Lys Val Pro 
    450                 455                 460                 
Gly Asp Leu Asn Lys Gly Ala Lys Gly Asn Phe Ile Tyr Ala Cys Thr 
465                 470                 475                 480 
Phe Val Gly Lys 
                

<210>  120
<211>  483
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  120
Met Glu His Val Asp Leu Pro Thr Gly Leu Val Lys Phe Ser Ser Asn 
1               5                   10                  15      
His His Leu Gln Leu Leu Arg Asp Thr Ala Asp Leu Ser Glu Ser Val 
            20                  25                  30          
Leu Pro Gly Val Glu Ala Ile Gly Leu Gly Tyr Asn Pro Phe Leu Gly 
        35                  40                  45              
Tyr Ala Gly Val Gly Ser Gly Thr Val Gln Leu Phe Asp Trp Asn Asn 
    50                  55                  60                  
Ala Lys Lys Lys Lys Val Ser Phe Lys Pro Glu Phe Val Val Pro Glu 
65                  70                  75                  80  
Ile Val Asp Val Gln Gln Asn Asp Ser Ala Ser Tyr Thr Asn Ile Ser 
                85                  90                  95      
Gly Asn Thr Val Thr Glu Tyr Gln Arg Ser Leu Ala Val Ser Val Ala 
            100                 105                 110         
Ile Glu Gly Lys Tyr Asn Phe Phe Ser Gly Ser Leu Ser Thr Asp Tyr 
        115                 120                 125             
Asp Glu Asn Ser Leu Ser Asn Ala Glu Asn Glu Phe Thr Arg Ile Gln 
    130                 135                 140                 
Gln Ser Ile Asn Leu Trp Ser Leu Arg Leu Pro Ser Val Lys Ser Leu 
145                 150                 155                 160 
Arg Asp Leu Met Leu Pro His Met Arg Glu Gln Leu Asp Glu Leu Asp 
                165                 170                 175     
Val Lys Asn Pro Ser Ala Ile Ser Arg Phe Phe Asp Arg Val Gly Ser 
            180                 185                 190         
His Phe Leu Thr Gly Ile Val Met Gly Gly Arg Ala Ile Leu Ala Ala 
        195                 200                 205             
Ser Thr Asn Lys Leu Lys Val Lys Arg Asp Tyr Ser Val Ser Val Ile 
    210                 215                 220                 
Ala Lys Ala Ser Tyr Glu Gly Leu Thr Gly Gln Leu Ser Ala Glu Ala 
225                 230                 235                 240 
Arg Thr Lys Tyr Gly Glu Ser Met Ser Ser Phe Thr Gln Tyr Ser Ser 
                245                 250                 255     
Thr His Gln Glu Val Arg Gly Gly Asp Gly Thr Lys Ala His Gly Val 
            260                 265                 270         
Phe Glu Gly Lys Ala Gly Phe Gln Ala Trp Val Asp Ser Val Gly Thr 
        275                 280                 285             
Ser Pro Asp Phe Val Asp Phe Val Pro Thr Ile Pro Met Leu Glu Ile 
    290                 295                 300                 
Trp Ser Leu Cys Lys Thr Asp Ser Gln Ala Glu Ala Met Lys Arg His 
305                 310                 315                 320 
Phe Asp Thr Val Trp Ala Arg Glu Gln Ser Asp Lys Tyr Arg Ile Lys 
                325                 330                 335     
Ala Asn Tyr Ile Asp Gln Leu Val Val Ile Thr Gly Asp Ser Ser Thr 
            340                 345                 350         
Ile Glu Pro Pro Val Gly Tyr Ser Lys Ile Glu Tyr Asp Leu Asn Ala 
        355                 360                 365             
Gly Ala Lys Gly Asp Phe Ile Tyr Leu Cys Tyr His Glu Gln Ala Trp 
    370                 375                 380                 
Tyr Pro Asp Asn Thr Lys Pro Ala Val Thr Glu Ile Lys Ile Ile Tyr 
385                 390                 395                 400 
Asp Arg Glu Pro Val Pro Thr Gly Tyr Ile Lys Leu Pro Gln Asp Leu 
                405                 410                 415     
Asn Lys Gly Ala Gly Gly Ala Asp Ile Tyr Leu Cys Tyr Lys Leu Glu 
            420                 425                 430         
Gly Tyr Asn Thr Asp Thr Ala Ile Asn Lys Ile Thr Val Ile Ser Gly 
        435                 440                 445             
Asn Asn Pro Asp Ile Asn Ala Pro Tyr Gly Tyr Glu Lys Val Pro Gly 
    450                 455                 460                 
Asp Leu Asn Lys Gly Ala Lys Gly Asn Phe Ile Tyr Ala Cys Thr Phe 
465                 470                 475                 480 
Val Gly Lys 
            

<210>  121
<211>  483
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  121
Met Glu His Val Asp Leu Pro Thr Gly Leu Val Lys Phe Ser Ser Asn 
1               5                   10                  15      
His His Leu Gln Leu Leu Arg Asp Thr Ala Asp Leu Ser Glu Ser Val 
            20                  25                  30          
Leu Pro Gly Val Glu Ala Ile Gly Leu Gly Tyr Asn Pro Phe Leu Gly 
        35                  40                  45              
Tyr Ala Gly Val Gly Ser Gly Thr Val Gln Leu Phe Asp Trp Asn Asn 
    50                  55                  60                  
Ala Lys Lys Lys Lys Val Ser Phe Lys Pro Glu Phe Val Val Pro Glu 
65                  70                  75                  80  
Ile Val Asp Val Gln Gln Asn Asp Ser Ala Ser Tyr Thr Asn Ile Ser 
                85                  90                  95      
Gly Asn Thr Val Thr Glu Tyr Gln Arg Ser Leu Ala Val Ser Val Ala 
            100                 105                 110         
Ile Glu Gly Lys Tyr Asn Phe Phe Ser Gly Ser Leu Ser Thr Asp Tyr 
        115                 120                 125             
Asp Glu Asn Ser Leu Arg Asn Ala Glu Asn Glu Phe Thr Arg Ile Gln 
    130                 135                 140                 
Gln Ser Ile Asn Leu Trp Ser Leu Arg Leu Pro Ser Val Lys Ser Leu 
145                 150                 155                 160 
Arg Asp Leu Met Leu Pro His Met Arg Glu Gln Leu Asp Glu Leu Asp 
                165                 170                 175     
Val Lys Asn Pro Ser Ala Ile Ser Arg Phe Phe Asp Arg Val Gly Ser 
            180                 185                 190         
His Phe Leu Thr Gly Ile Val Met Gly Gly Arg Ala Ile Leu Ala Ala 
        195                 200                 205             
Ser Thr Asn Lys Leu Lys Val Lys Arg Asp Tyr Ser Val Ser Val Val 
    210                 215                 220                 
Ala Lys Ala Ser Tyr Glu Gly Leu Thr Gly Gln Leu Ser Ala Glu Ala 
225                 230                 235                 240 
Arg Thr Lys Tyr Gly Glu Ser Met Ser Ser Phe Thr Gln Tyr Ser Ser 
                245                 250                 255     
Thr His Gln Glu Val Arg Gly Gly Asp Gly Thr Lys Ala His Gly Val 
            260                 265                 270         
Phe Glu Gly Lys Ala Gly Phe Gln Ala Trp Val Asp Ser Val Gly Thr 
        275                 280                 285             
Ser Pro Asp Phe Val Asp Phe Val Pro Thr Ile Pro Met Leu Glu Ile 
    290                 295                 300                 
Trp Ser Leu Cys Lys Thr Asp Ser Gln Ala Glu Ala Met Lys Arg His 
305                 310                 315                 320 
Phe Asp Thr Val Trp Ala Arg Glu Gln Ser Asp Lys Tyr Arg Val Lys 
                325                 330                 335     
Ala Asn Tyr Ile Asp Gln Leu Val Val Ile Thr Gly Gly Ser Ser Thr 
            340                 345                 350         
Ile Glu Pro Pro Val Gly Tyr Ser Lys Ile Glu Tyr Asp Leu Asn Ala 
        355                 360                 365             
Gly Ala Lys Gly Asp Phe Ile Tyr Leu Cys Tyr His Glu Gln Ala Trp 
    370                 375                 380                 
Tyr Pro Asp Asn Thr Lys Pro Ala Val Thr Ala Ile Lys Ile Ile Tyr 
385                 390                 395                 400 
Asp Arg Glu Pro Val Pro Thr Gly Tyr Ile Lys Leu Pro Gln Asp Leu 
                405                 410                 415     
Asn Lys Gly Ala Gly Gly Ala Asp Ile Tyr Leu Cys Tyr Lys Leu Glu 
            420                 425                 430         
Gly Tyr Asn Thr Asp Thr Ala Ile Asn Lys Val Thr Val Ile Gly Gly 
        435                 440                 445             
Asn Asn Ala Asp Ile Asn Ala Pro Tyr Gly Tyr Leu Lys Val Pro Gly 
    450                 455                 460                 
Asp Leu Asn Arg Gly Ala Gly Gly Asn Phe Ile Tyr Ala Cys Thr Phe 
465                 470                 475                 480 
Val Gly Lys 
            

<210>  122
<211>  484
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  122
Met Glu His Val Asp Leu Pro Thr Gly Leu Val Lys Phe Ser Ser Asn 
1               5                   10                  15      
His His Leu Gln Leu Leu Arg Asp Thr Ala Asp Leu Ser Glu Ser Val 
            20                  25                  30          
Leu Pro Gly Val Glu Ala Ile Gly Leu Gly Tyr Asn Gln Phe Leu Gly 
        35                  40                  45              
Tyr Ala Gly Val Gly Ser Gly Thr Val Gln Leu Phe Asp Trp Asn Asn 
    50                  55                  60                  
Ala Lys Lys Lys Lys Val Ser Phe Lys Pro Glu Phe Val Val Pro Glu 
65                  70                  75                  80  
Ile Val Asp Val Gln Gln Asn Asp Ser Ala Thr Tyr Thr Asn Val Ser 
                85                  90                  95      
Gly Asn Thr Ile Ser Glu Tyr Gln Arg Ser Leu Ala Thr Ser Val Ala 
            100                 105                 110         
Ile Glu Gly Arg Tyr Asn Phe Phe Ser Gly Ser Leu Ser Thr Asp Phe 
        115                 120                 125             
Asp Ser Asn Ser Leu Arg Asn Ala Glu Asn Glu Phe Thr Arg Ile Gln 
    130                 135                 140                 
Gln Ser Ile Asn Leu Trp Ser Leu Arg Leu Pro Ser Val Lys Ser Leu 
145                 150                 155                 160 
Arg Glu Leu Met Leu Pro His Met Arg Gln Gln Leu Asp Glu Leu Asn 
                165                 170                 175     
Val Asn Asp Pro Lys Ala Ile Ser Arg Tyr Phe Asp Arg Val Gly Ser 
            180                 185                 190         
His Phe Leu Thr Gly Ile Val Met Gly Gly Arg Ala Ile Leu Ala Ser 
        195                 200                 205             
Ser Thr Asn Lys Leu Arg Val Lys Arg Asp Tyr Ser Val Ser Val Val 
    210                 215                 220                 
Ala Lys Ala Ser Tyr Glu Gly Leu Thr Gly Gln Leu Ser Ala Glu Ala 
225                 230                 235                 240 
Lys Ala Lys Tyr Gly Glu Ser Ile Ser Ser Phe Thr Gln Tyr Ser Asn 
                245                 250                 255     
Thr His Gln Glu Val Arg Gly Gly Asp Gly Ala Lys Ala His Gly Val 
            260                 265                 270         
Phe Ser Gly Lys Lys Glu Asp Phe Gln Ala Trp Val Asp Ser Val Ser 
        275                 280                 285             
Ala Ser Pro Asp Phe Val Asp Phe Val Pro Thr Ile Pro Met Gln Glu 
    290                 295                 300                 
Ile Trp Thr Leu Cys Ser Ser Glu Ala Gln Ala Glu Ala Met Arg Lys 
305                 310                 315                 320 
His Tyr Asp Asp Val Trp Ala Pro Ala Gln Ser Glu Lys Tyr Arg Val 
                325                 330                 335     
Lys Ala Asn Tyr Ile Asp Gln Leu Val Val Ile Thr Gly Gly Ser Ser 
            340                 345                 350         
Thr Ile Glu Pro Pro Val Gly Tyr Ser Lys Ile Glu Tyr Asp Leu Asn 
        355                 360                 365             
Ala Gly Ala Gly Gly Asp Phe Ile Tyr Leu Cys Tyr His Glu Gln Thr 
    370                 375                 380                 
Trp Gln Ala Asp Arg Pro Lys Asp Ala Val Thr Asp Ile Arg Ile Ile 
385                 390                 395                 400 
Phe Asn Lys Glu Pro Thr Pro Pro Gly Tyr Thr Lys Leu Pro Gln Asp 
                405                 410                 415     
Leu Asn Lys Gly Ala Gly Gly Asp Asp Val Phe Leu Cys Tyr Lys Thr 
            420                 425                 430         
Glu Ala Tyr Asn Thr Asp Thr Ala Ile Asn Lys Val Thr Val Ile Gly 
        435                 440                 445             
Gly Asn Asn Ala Asp Ile Asn Ala Pro Tyr Gly Tyr Leu Lys Val Pro 
    450                 455                 460                 
Gly Asp Leu Asn Arg Gly Ala Gly Gly Asn Phe Ile Tyr Ala Cys Thr 
465                 470                 475                 480 
Phe Val Gly Lys 
                

<210>  123
<211>  484
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  123
Met Glu His Val Asp Leu Pro Thr Gly Leu Val Lys Phe Ser Ser Asn 
1               5                   10                  15      
His His Leu Gln Leu Leu Arg Asp Thr Ala Asp Leu Ser Glu Ser Val 
            20                  25                  30          
Leu Pro Gly Val Glu Ala Ile Gly Leu Gly Tyr Asn Pro Phe Leu Gly 
        35                  40                  45              
Tyr Ala Gly Val Gly Ser Gly Thr Val Gln Leu Phe Asp Trp Asn Asn 
    50                  55                  60                  
Ala Lys Lys Lys Lys Val Ser Phe Lys Pro Glu Phe Val Val Pro Glu 
65                  70                  75                  80  
Ile Val Asp Val Gln Gln Asn Asp Ser Ala Ser Tyr Thr Asn Ile Ser 
                85                  90                  95      
Gly Asn Thr Val Thr Glu Tyr Gln Arg Ser Leu Ala Val Ser Val Ala 
            100                 105                 110         
Ile Glu Gly Lys Tyr Asn Phe Phe Ser Gly Ser Leu Ser Thr Asp Tyr 
        115                 120                 125             
Asp Glu Asn Ser Leu Arg Asn Ala Glu Asn Glu Phe Thr Arg Ile Gln 
    130                 135                 140                 
Gln Ser Ile Asn Leu Trp Ser Leu Arg Leu Pro Ser Val Lys Ser Leu 
145                 150                 155                 160 
Arg Asp Leu Met Leu Pro His Met Arg Glu Gln Leu Asp Glu Leu Asp 
                165                 170                 175     
Val Lys Asn Pro Ser Ala Ile Ser Arg Phe Phe Asp Arg Val Gly Ser 
            180                 185                 190         
His Phe Leu Thr Gly Ile Val Met Gly Gly Arg Ala Ile Leu Ala Ala 
        195                 200                 205             
Ser Thr Asn Lys Leu Lys Val Lys Arg Asp Tyr Ser Val Ser Val Ile 
    210                 215                 220                 
Ala Lys Ala Ser Tyr Glu Gly Leu Thr Gly Gln Leu Ser Ala Glu Ala 
225                 230                 235                 240 
Arg Thr Lys Tyr Gly Glu Ser Met Ser Ser Phe Thr Gln Tyr Ser Ser 
                245                 250                 255     
Thr His Gln Glu Val Arg Gly Gly Asp Gly Ala Lys Ala His Gly Val 
            260                 265                 270         
Phe Ser Gly Lys Lys Glu Asp Phe Gln Ala Trp Val Asp Ser Val Ser 
        275                 280                 285             
Ala Ser Pro Asp Phe Val Asp Phe Val Pro Thr Ile Pro Met Leu Glu 
    290                 295                 300                 
Ile Trp Ser Leu Cys Lys Thr Asp Ser Gln Ala Glu Ala Met Lys Arg 
305                 310                 315                 320 
His Phe Asp Thr Val Trp Ala Arg Glu Gln Ser Asp Lys Tyr Arg Ile 
                325                 330                 335     
Lys Ala Asn Tyr Ile Asp Gln Leu Val Val Ile Thr Gly Asp Ser Ser 
            340                 345                 350         
Thr Ile Glu Pro Pro Ala Gly Tyr Thr Lys Ile Pro Tyr Asp Leu Asn 
        355                 360                 365             
Ala Gly Ala Lys Gly Asp Phe Ile Tyr Leu Cys Tyr His Glu Gln Ala 
    370                 375                 380                 
Trp Tyr Pro Asp Asn Thr Lys Pro Ala Val Thr Ala Ile Lys Ile Ile 
385                 390                 395                 400 
Tyr Asp Arg Glu Pro Val Pro Thr Gly Tyr Ile Lys Leu Pro Gln Asp 
                405                 410                 415     
Leu Asn Lys Gly Ala Gly Gly Ala Asp Ile Tyr Leu Cys Tyr Lys Leu 
            420                 425                 430         
Glu Gly Tyr Asn Thr Asp Thr Ala Ile Asn Lys Ile Thr Val Ile Arg 
        435                 440                 445             
Gly Asn Asn Pro Asp Ile Asn Ala Pro Tyr Gly Tyr Glu Lys Val Pro 
    450                 455                 460                 
Gly Asp Leu Asn Lys Gly Ala Lys Gly Asn Phe Ile Tyr Ala Cys Thr 
465                 470                 475                 480 
Phe Val Gly Lys 
                

<210>  124
<211>  483
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  124
Met Glu His Val Asp Leu Pro Thr Gly Leu Val Lys Phe Ser Ser Asn 
1               5                   10                  15      
His His Leu Gln Leu Leu Arg Asp Thr Ala Asp Leu Ser Glu Ser Val 
            20                  25                  30          
Leu Pro Gly Val Glu Ala Ile Gly Leu Gly Tyr Asn Pro Phe Leu Gly 
        35                  40                  45              
Tyr Ala Gly Val Gly Ser Gly Thr Val Gln Leu Phe Asp Trp Asn Asn 
    50                  55                  60                  
Ala Lys Lys Lys Lys Val Ser Phe Lys Pro Glu Leu Val Val Pro Glu 
65                  70                  75                  80  
Ile Val Asp Val Gln Gln Asn Asp Ser Ala Ser Tyr Thr Asn Ile Ser 
                85                  90                  95      
Gly Asn Thr Val Thr Glu Tyr Gln Arg Ser Leu Ala Val Ser Val Ala 
            100                 105                 110         
Ile Glu Gly Arg Tyr Asn Phe Phe Ser Gly Ser Leu Ser Thr Asp Phe 
        115                 120                 125             
Asp Ser Asn Ser Leu Arg Asn Ala Glu Asn Glu Phe Thr Arg Ile Gln 
    130                 135                 140                 
Gln Ser Ile Asn Leu Trp Ser Leu Arg Leu Pro Ser Val Lys Ser Leu 
145                 150                 155                 160 
Arg Asp Leu Met Leu Pro His Met Arg Glu Gln Leu Asp Glu Leu Asp 
                165                 170                 175     
Val Lys Asn Pro Ser Ala Ile Ser Arg Phe Phe Asp Arg Val Gly Ser 
            180                 185                 190         
His Phe Leu Thr Gly Ile Val Met Gly Gly Arg Ala Ile Leu Ala Ala 
        195                 200                 205             
Ser Thr Asn Lys Leu Lys Val Lys Arg Asp Tyr Ser Val Ser Val Ile 
    210                 215                 220                 
Ala Lys Ala Ser Tyr Glu Gly Leu Thr Gly Gln Leu Ser Ala Glu Ala 
225                 230                 235                 240 
Arg Thr Lys Tyr Gly Glu Ser Met Ser Ser Phe Thr Gln Tyr Ser Ser 
                245                 250                 255     
Thr His Gln Glu Val Arg Gly Gly Asp Gly Thr Lys Ala His Gly Val 
            260                 265                 270         
Phe Glu Gly Lys Ala Gly Phe Gln Ala Trp Val Asp Ser Val Gly Thr 
        275                 280                 285             
Ser Pro Asp Phe Val Asp Phe Val Pro Thr Ile Pro Met Leu Glu Ile 
    290                 295                 300                 
Trp Ser Leu Cys Lys Thr Asp Ser Gln Ala Glu Ala Met Lys Arg His 
305                 310                 315                 320 
Phe Asp Thr Val Trp Ala Arg Glu Gln Ser Asp Lys Tyr Arg Ile Lys 
                325                 330                 335     
Ala Asn Tyr Ile Asp Gln Leu Val Val Ile Thr Gly Asp Ser Ser Thr 
            340                 345                 350         
Ile Glu Pro Pro Ala Gly Tyr Thr Lys Ile Pro Tyr Asp Leu Asn Ala 
        355                 360                 365             
Gly Ala Lys Gly Asp Phe Ile Tyr Leu Cys Tyr His Glu Gln Ala Trp 
    370                 375                 380                 
Tyr Pro Asp Asn Thr Lys Pro Ala Val Thr Ala Ile Lys Ile Ile Tyr 
385                 390                 395                 400 
Asp Arg Glu Pro Val Pro Thr Gly Tyr Ile Lys Leu Pro Gln Asp Leu 
                405                 410                 415     
Asn Lys Gly Ala Gly Gly Ala Asp Ile Tyr Leu Cys Tyr Lys Leu Glu 
            420                 425                 430         
Gly Tyr Asn Thr Asp Thr Ala Ile Asn Lys Ile Thr Val Ile Ser Gly 
        435                 440                 445             
Asn Asn Pro Asp Ile Asn Ala Pro Tyr Gly Tyr Glu Lys Val Pro Gly 
    450                 455                 460                 
Asp Leu Asn Lys Gly Ala Lys Gly Asn Phe Ile Tyr Ala Cys Thr Phe 
465                 470                 475                 480 
Val Gly Lys 
            

<210>  125
<211>  483
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  125
Met Glu His Val Asp Leu Pro Gln Gly Leu Val Asn Phe Ser Thr Gln 
1               5                   10                  15      
His Leu Gln Leu Ile Arg Phe Lys Ala Gly Leu Asn Glu Thr Val Leu 
            20                  25                  30          
Pro Gly Val Glu Ala Ile Gly Leu Gly Tyr Asn Pro Phe Ile Ser Tyr 
        35                  40                  45              
Ala Ser Val Asn Ser Gly Ala Val Gln Leu Phe Asp Trp Ala Thr Ala 
    50                  55                  60                  
Lys Lys Arg Glu Val Pro Phe Arg Ala Gly Tyr Phe Val Pro Glu Ile 
65                  70                  75                  80  
Val Asp Val Gln Gln Asn Asp Ser Ala Thr Tyr Thr Asn Val Ser Gly 
                85                  90                  95      
Asn Thr Ile Ser Glu Tyr Gln Arg Ser Leu Ala Thr Ser Val Ala Ile 
            100                 105                 110         
Glu Gly Arg Tyr Asn Phe Phe Ser Gly Ser Leu Ser Thr Asp Tyr Asp 
        115                 120                 125             
Glu Asn Ser Leu Arg Asn Ala Glu Asn Glu Phe Thr Arg Ile Gln Gln 
    130                 135                 140                 
Ser Ile Asn Leu Trp Ser Leu Arg Leu Pro Ser Val Lys Ser Leu Arg 
145                 150                 155                 160 
Asp Leu Met Leu Pro His Met Arg Glu Gln Leu Asp Glu Leu Asp Val 
                165                 170                 175     
Lys Asn Pro Ser Ala Ile Ser Arg Phe Phe Asp Arg Val Gly Ser His 
            180                 185                 190         
Phe Leu Thr Gly Ile Val Met Gly Gly Arg Ala Ile Leu Ala Ala Ser 
        195                 200                 205             
Thr Asn Lys Leu Arg Val Lys Arg Asp Tyr Ser Val Ser Val Val Ala 
    210                 215                 220                 
Lys Ala Ser Tyr Glu Gly Leu Thr Gly Gln Leu Ser Ala Glu Ala Lys 
225                 230                 235                 240 
Ala Lys Tyr Gly Glu Ser Ile Ser Ser Phe Thr Gln Tyr Ser Asn Thr 
                245                 250                 255     
His Gln Glu Val Arg Gly Gly Asp Gly Ala Lys Ala His Gly Val Phe 
            260                 265                 270         
Ser Gly Lys Lys Glu Asp Phe Gln Ala Trp Val Asp Ser Val Gly Ala 
        275                 280                 285             
Ser Pro Asp Phe Val Asp Phe Val Pro Thr Ile Pro Met Leu Glu Ile 
    290                 295                 300                 
Trp Ser Leu Cys Lys Thr Asp Ser Gln Ala Glu Ala Met Lys Arg His 
305                 310                 315                 320 
Phe Asp Thr Val Trp Ala Arg Glu Gln Ser Asp Lys Tyr Arg Ile Lys 
                325                 330                 335     
Ala Asn Tyr Ile Asp Gln Leu Val Val Ile Thr Gly Asp Ser Ser Thr 
            340                 345                 350         
Ile Glu Pro Pro Ala Gly Tyr Thr Lys Ile Pro Tyr Asp Leu Asn Ala 
        355                 360                 365             
Gly Ala Gly Gly Asp Phe Ile Tyr Leu Cys Tyr His Glu Gln Thr Trp 
    370                 375                 380                 
Gln Ala Asp Arg Pro Lys Asp Ala Val Thr Asp Ile Arg Ile Ile Phe 
385                 390                 395                 400 
Asn Lys Glu Pro Thr Pro Pro Gly Tyr Thr Lys Leu Pro Gln Asp Leu 
                405                 410                 415     
Asn Lys Gly Ala Gly Gly Asp Asp Val Phe Leu Cys Tyr Lys Thr Glu 
            420                 425                 430         
Ala Tyr Asn Thr Asp Thr Ala Ile Asn Lys Ile Thr Val Ile Ser Gly 
        435                 440                 445             
Asn Asn Pro Asp Ile Asn Ala Pro Tyr Gly Tyr Glu Lys Val Pro Gly 
    450                 455                 460                 
Asp Leu Asn Lys Gly Ala Lys Gly Asn Phe Ile Tyr Ala Cys Thr Phe 
465                 470                 475                 480 
Val Gly Lys 
            

<210>  126
<211>  484
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  126
Met Glu His Val Asp Leu Pro Thr Gly Leu Val Lys Phe Ser Ser Asn 
1               5                   10                  15      
His His Leu Gln Leu Leu Arg Asp Thr Ala Asp Leu Ser Glu Ser Val 
            20                  25                  30          
Leu Pro Gly Val Glu Ala Ile Gly Leu Gly Tyr Asn Pro Phe Leu Gly 
        35                  40                  45              
Tyr Ala Gly Val Gly Ser Gly Thr Val Gln Leu Phe Asp Trp Asn Asn 
    50                  55                  60                  
Ala Lys Lys Lys Lys Val Ser Phe Lys Pro Glu Phe Val Val Pro Glu 
65                  70                  75                  80  
Ile Val Asp Val Gln Gln Asn Asp Ser Ala Thr Tyr Thr Asn Ile Ser 
                85                  90                  95      
Gly Asn Thr Val Thr Glu Tyr Gln Arg Ser Leu Ala Val Ser Val Ala 
            100                 105                 110         
Ile Glu Gly Lys Tyr Asn Phe Phe Ser Gly Ser Leu Ser Thr Asp Tyr 
        115                 120                 125             
Asp Glu Asn Ser Leu Arg Asn Ala Glu Asn Glu Phe Thr Arg Ile Gln 
    130                 135                 140                 
Gln Ser Ile Asn Leu Trp Ser Leu Arg Leu Pro Ser Val Lys Ser Leu 
145                 150                 155                 160 
Arg Glu Leu Met Leu Pro His Met Arg Gln Gln Leu Asp Glu Leu Asn 
                165                 170                 175     
Val Asn Asp Pro Lys Ala Ile Ser Arg Tyr Phe Asp Arg Val Gly Ser 
            180                 185                 190         
His Phe Leu Thr Gly Ile Val Met Gly Gly Arg Ala Ile Leu Ala Ala 
        195                 200                 205             
Ser Thr Asn Lys Leu Arg Val Lys Arg Asp Tyr Ser Val Ser Val Val 
    210                 215                 220                 
Ala Lys Ala Ser Tyr Glu Gly Leu Thr Gly Gln Leu Ser Ala Glu Ala 
225                 230                 235                 240 
Arg Thr Lys Tyr Gly Glu Ser Met Ser Ser Phe Thr Gln Tyr Ser Asn 
                245                 250                 255     
Thr His Gln Glu Val Arg Gly Gly Asp Gly Ala Lys Ala His Gly Val 
            260                 265                 270         
Phe Ser Gly Lys Lys Glu Asp Phe Gln Ala Trp Val Asp Ser Val Ser 
        275                 280                 285             
Thr Ser Pro Asp Phe Val Asp Phe Val Pro Thr Ile Pro Met Leu Glu 
    290                 295                 300                 
Ile Trp Ser Leu Cys Lys Thr Asp Ser Gln Ala Glu Ala Met Lys Arg 
305                 310                 315                 320 
His Phe Asp Thr Val Trp Ala Arg Glu Gln Ser Asp Lys Tyr Arg Ile 
                325                 330                 335     
Lys Ala Asn Tyr Ile Asp Gln Leu Val Val Ile Thr Gly Asp Ser Ser 
            340                 345                 350         
Thr Ile Glu Pro Pro Ala Gly Tyr Thr Lys Ile Pro Tyr Asp Leu Asn 
        355                 360                 365             
Ala Gly Ala Lys Gly Asp Phe Ile Tyr Leu Cys Tyr His Glu Gln Ala 
    370                 375                 380                 
Trp Tyr Pro Asp Asn Thr Lys Pro Ala Val Thr Ala Ile Lys Ile Ile 
385                 390                 395                 400 
Tyr Asp Arg Glu Pro Val Pro Thr Gly Tyr Ile Lys Leu Pro Gln Asp 
                405                 410                 415     
Leu Asn Lys Gly Ala Gly Gly Ala Asp Ile Tyr Leu Cys Tyr Lys Leu 
            420                 425                 430         
Glu Gly Tyr Asn Thr Asp Thr Ala Ile Asn Lys Val Thr Val Ile Gly 
        435                 440                 445             
Gly Asn Asn Ala Asp Ile Asn Ala Pro Tyr Gly Tyr Leu Lys Val Pro 
    450                 455                 460                 
Gly Asp Leu Asn Arg Gly Ala Gly Gly Asn Phe Ile Tyr Ala Cys Thr 
465                 470                 475                 480 
Phe Val Gly Lys 
                

<210>  127
<211>  483
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  127
Met Glu Asn Val Asp Leu Pro Thr Gly Leu Val Lys Phe Ser Ser Asn 
1               5                   10                  15      
His His Leu Gln Leu Leu Arg Asp Thr Ala Asp Leu Ser Glu Ser Val 
            20                  25                  30          
Leu Pro Gly Val Glu Ala Ile Gly Leu Gly Tyr Asn Pro Phe Leu Gly 
        35                  40                  45              
Tyr Ala Gly Val Gly Ser Gly Thr Val Gln Leu Phe Asp Trp Asn Asn 
    50                  55                  60                  
Ala Lys Lys Lys Lys Val Ser Phe Lys Pro Glu Phe Val Val Pro Glu 
65                  70                  75                  80  
Ile Val Asp Val Gln Gln Asn Asp Ser Ala Thr Tyr Thr Asn Ile Ser 
                85                  90                  95      
Gly Asn Thr Val Thr Glu Tyr Gln Arg Ser Leu Ala Val Ser Val Ala 
            100                 105                 110         
Ile Glu Gly Lys Tyr Asn Phe Phe Ser Gly Ser Leu Ser Thr Asp Tyr 
        115                 120                 125             
Asp Glu Asn Ser Leu Arg Asn Ala Glu Asn Glu Phe Thr Arg Ile Gln 
    130                 135                 140                 
Gln Ser Ile Asn Leu Trp Ser Leu Arg Leu Pro Ser Val Lys Ser Leu 
145                 150                 155                 160 
Arg Asp Leu Met Leu Pro His Met Arg Glu Gln Leu Asp Glu Leu Asp 
                165                 170                 175     
Val Lys Asn Pro Ser Ala Ile Ser Arg Phe Phe Asp Arg Val Gly Ser 
            180                 185                 190         
His Phe Leu Thr Gly Ile Val Met Gly Gly Arg Ala Ile Leu Ala Ser 
        195                 200                 205             
Ser Thr Asn Lys Leu Lys Val Lys Arg Asp Tyr Ser Val Ser Val Ile 
    210                 215                 220                 
Ala Lys Ala Ser Tyr Glu Gly Leu Thr Gly Gln Leu Ser Ala Glu Ala 
225                 230                 235                 240 
Arg Thr Lys Tyr Gly Glu Ser Met Ser Ser Phe Thr Gln Tyr Ser Ser 
                245                 250                 255     
Thr His Gln Glu Val Arg Gly Gly Asp Gly Thr Lys Ala His Gly Val 
            260                 265                 270         
Phe Glu Gly Lys Ala Gly Phe Gln Ala Trp Val Asp Ser Val Gly Thr 
        275                 280                 285             
Ser Pro Asp Phe Val Asp Phe Val Pro Thr Ile Pro Met Gln Glu Ile 
    290                 295                 300                 
Trp Thr Leu Cys Ser Ser Glu Ala Gln Ala Glu Ala Met Arg Lys His 
305                 310                 315                 320 
Tyr Asp Asp Val Trp Ala Pro Ala Gln Ser Glu Lys Tyr Arg Val Lys 
                325                 330                 335     
Ala Asn Tyr Ile Asp Gln Leu Val Val Ile Thr Gly Asp Ser Ser Thr 
            340                 345                 350         
Ile Glu Pro Pro Ala Gly Tyr Thr Lys Ile Pro Tyr Asp Leu Asn Ala 
        355                 360                 365             
Gly Ala Lys Gly Asp Phe Ile Tyr Leu Cys Tyr Asn Glu Gln Ala Trp 
    370                 375                 380                 
Tyr Pro Asp Asn Thr Lys Pro Ala Val Thr Ala Ile Lys Ile Ile Tyr 
385                 390                 395                 400 
Asp Arg Glu Pro Val Pro Thr Gly Tyr Ile Lys Leu Pro Gln Asp Leu 
                405                 410                 415     
Asn Lys Gly Ala Gly Gly Ala Asp Ile Tyr Leu Cys Tyr Lys Leu Glu 
            420                 425                 430         
Gly Tyr Asn Thr Asp Thr Ala Ile Asn Lys Val Thr Val Ile Gly Gly 
        435                 440                 445             
Asn Asn Ala Asp Ile Asn Ala Pro Tyr Gly Tyr Leu Lys Val Pro Gly 
    450                 455                 460                 
Asp Leu Asn Arg Gly Ala Gly Gly Asn Phe Ile Tyr Ala Cys Thr Phe 
465                 470                 475                 480 
Val Gly Lys 
            

<210>  128
<211>  484
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  128
Met Glu His Ile Asp Leu Pro Thr Gly Leu Val Lys Phe Ser Ser Asn 
1               5                   10                  15      
His His Leu Gln Leu Leu Arg Asp Thr Ala Asp Leu Ser Glu Ser Val 
            20                  25                  30          
Leu Pro Gly Val Glu Ala Ile Gly Leu Gly Tyr Asn Pro Phe Leu Gly 
        35                  40                  45              
Tyr Ala Gly Val Gly Ser Gly Thr Val Gln Leu Phe Asp Trp Asn Asn 
    50                  55                  60                  
Ala Lys Lys Lys Lys Val Ser Phe Lys Pro Glu Phe Val Val Pro Glu 
65                  70                  75                  80  
Ile Val Asp Val Gln Gln Asn Asp Ser Ala Ser Tyr Thr Asn Val Ser 
                85                  90                  95      
Gly Asn Thr Ile Ser Glu Tyr Gln Arg Ser Leu Ala Thr Ser Val Ala 
            100                 105                 110         
Ile Glu Gly Arg Tyr Asn Phe Phe Ser Gly Ser Leu Ser Thr Asp Phe 
        115                 120                 125             
Asp Ser Asn Ser Leu Arg Asn Ala Glu Asn Glu Phe Thr Arg Ile Gln 
    130                 135                 140                 
Gln Ser Ile Asn Leu Trp Ser Leu Arg Leu Pro Ser Val Lys Ser Leu 
145                 150                 155                 160 
Arg Glu Leu Met Leu Pro His Met Arg Gln Gln Leu Asp Glu Leu Asn 
                165                 170                 175     
Val Asn Asp Pro Lys Ala Ile Ser Arg Tyr Phe Asp Arg Val Gly Ser 
            180                 185                 190         
His Phe Leu Thr Gly Ile Val Met Gly Gly Arg Ala Ile Leu Ala Ser 
        195                 200                 205             
Ser Thr Asn Lys Leu Lys Val Lys Arg Asp Tyr Ser Val Ser Val Ile 
    210                 215                 220                 
Ala Lys Ala Ser Tyr Glu Gly Leu Thr Gly Gln Leu Ser Ala Glu Ala 
225                 230                 235                 240 
Arg Thr Lys Tyr Gly Glu Ser Ile Ser Ser Phe Thr Gln Tyr Ser Asn 
                245                 250                 255     
Thr His Gln Glu Val Arg Gly Gly Asp Gly Ala Lys Ala His Gly Val 
            260                 265                 270         
Phe Ser Gly Lys Lys Glu Asp Phe Gln Ala Trp Val Asp Ser Val Gly 
        275                 280                 285             
Ala Ser Pro Asp Phe Val Asp Phe Val Pro Thr Ile Pro Met Gln Glu 
    290                 295                 300                 
Ile Trp Thr Leu Cys Ser Ser Glu Ala Gln Ala Glu Ala Met Arg Lys 
305                 310                 315                 320 
His Tyr Asp Asp Val Trp Ala Pro Ala Gln Ser Glu Lys Tyr Arg Val 
                325                 330                 335     
Lys Ala Asn Tyr Ile Asp Gln Leu Val Val Ile Thr Gly Gly Ser Ser 
            340                 345                 350         
Thr Ile Glu Pro Pro Val Gly Tyr Ser Lys Ile Glu Tyr Asp Leu Asn 
        355                 360                 365             
Ala Gly Ala Gly Gly Asp Phe Ile Tyr Leu Cys Tyr His Glu Gln Thr 
    370                 375                 380                 
Trp Gln Ala Asp Arg Pro Lys Asp Ala Val Thr Asp Ile Arg Ile Ile 
385                 390                 395                 400 
Phe Asn Lys Glu Pro Thr Pro Pro Gly Tyr Thr Lys Leu Pro Gln Asp 
                405                 410                 415     
Leu Asn Lys Gly Ala Gly Gly Asp Asp Val Phe Leu Cys Tyr Lys Thr 
            420                 425                 430         
Glu Ala Tyr Asn Thr Asp Thr Ala Ile Asn Lys Val Thr Val Ile Gly 
        435                 440                 445             
Gly Asn Asn Ala Asp Ile Asn Ala Pro Tyr Gly Tyr Leu Lys Val Pro 
    450                 455                 460                 
Gly Asp Leu Asn Arg Gly Ala Gly Gly Asn Phe Ile Tyr Ala Cys Thr 
465                 470                 475                 480 
Phe Val Gly Lys 
                

<210>  129
<211>  482
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  129
Met Glu His Val Asp Leu Pro Gln Gly Leu Val Asn Phe Ser Thr Gln 
1               5                   10                  15      
His Leu Gln Leu Ile Arg Phe Lys Ala Gly Leu Asn Glu Thr Val Leu 
            20                  25                  30          
Pro Gly Val Glu Ala Ile Gly Leu Gly Tyr Asn Pro Phe Ile Ser Tyr 
        35                  40                  45              
Ala Ser Val Asn Ser Gly Ala Val Gln Leu Phe Asp Trp Ala Thr Ala 
    50                  55                  60                  
Lys Lys Arg Glu Val Pro Phe Lys Ala Gly Tyr Phe Val Pro Glu Ile 
65                  70                  75                  80  
Val Asp Val Gln Gln Asn Asp Ser Ala Ser Tyr Thr Asn Val Ser Gly 
                85                  90                  95      
Asn Thr Ile Ser Glu Tyr Gln Arg Ser Leu Ala Thr Ser Val Ala Ile 
            100                 105                 110         
Glu Gly Arg Tyr Asn Phe Phe Ser Gly Ser Leu Ser Thr Asp Phe Asp 
        115                 120                 125             
Ser Asn Ser Leu Arg Asn Ala Glu Asn Glu Phe Thr Arg Ile Gln Gln 
    130                 135                 140                 
Ser Ile Asn Leu Trp Ser Leu Arg Leu Pro Ser Val Lys Ser Leu Arg 
145                 150                 155                 160 
Asp Leu Met Leu Pro His Met Arg Glu Gln Leu Asp Glu Leu Asp Val 
                165                 170                 175     
Lys Asn Pro Ser Ala Ile Ser Arg Phe Phe Asp Arg Val Gly Ser His 
            180                 185                 190         
Phe Leu Thr Gly Ile Val Met Gly Gly Arg Ala Ile Leu Ala Ser Ser 
        195                 200                 205             
Thr Asn Lys Leu Lys Val Lys Arg Asp Tyr Ser Val Ser Val Ile Ala 
    210                 215                 220                 
Lys Ala Ser Tyr Glu Gly Leu Thr Gly Gln Leu Ser Ala Glu Ala Arg 
225                 230                 235                 240 
Thr Lys Tyr Gly Glu Ser Met Ser Ser Phe Thr Gln Tyr Ser Ser Thr 
                245                 250                 255     
His Gln Glu Val Arg Gly Gly Asp Gly Thr Lys Ala His Gly Val Phe 
            260                 265                 270         
Glu Gly Lys Ala Gly Phe Gln Ala Trp Val Asp Ser Val Gly Thr Ser 
        275                 280                 285             
Pro Asp Phe Val Asp Phe Val Pro Thr Ile Pro Met Leu Glu Ile Trp 
    290                 295                 300                 
Ser Leu Cys Lys Thr Asp Ser Gln Ala Glu Ala Met Lys Arg His Phe 
305                 310                 315                 320 
Asp Thr Val Trp Ala Arg Glu Gln Ser Asp Lys Tyr Arg Ile Lys Ala 
                325                 330                 335     
Asn Tyr Ile Asp Gln Leu Val Val Ile Thr Gly Asp Ser Ser Thr Ile 
            340                 345                 350         
Glu Pro Pro Ala Gly Tyr Thr Lys Ile Pro Tyr Asp Leu Asn Ala Gly 
        355                 360                 365             
Ala Lys Gly Asp Phe Ile Tyr Leu Cys Tyr His Glu Gln Ala Trp Tyr 
    370                 375                 380                 
Pro Asp Asn Thr Lys Pro Ala Val Thr Ala Ile Lys Ile Ile Tyr Asp 
385                 390                 395                 400 
Arg Glu Pro Val Pro Thr Gly Tyr Ile Lys Leu Pro Gln Asp Leu Asn 
                405                 410                 415     
Lys Gly Ala Gly Gly Ala Asp Ile Tyr Leu Cys Tyr Lys Thr Glu Ala 
            420                 425                 430         
Tyr Asn Thr Asp Thr Ala Ile Asn Lys Val Thr Val Ile Gly Gly Asn 
        435                 440                 445             
Asn Ala Asp Ile Asn Ala Pro Tyr Gly Tyr Leu Lys Val Pro Gly Asp 
    450                 455                 460                 
Leu Asn Arg Gly Ala Gly Gly Asn Phe Ile Tyr Ala Cys Thr Phe Val 
465                 470                 475                 480 
Gly Lys 
        

<210>  130
<211>  483
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  130
Met Glu His Val Asp Leu Pro Thr Gly Leu Val Lys Phe Ser Ser Asn 
1               5                   10                  15      
His His Leu Gln Leu Leu Arg Asp Thr Ala Asp Leu Ser Glu Ser Val 
            20                  25                  30          
Leu Pro Gly Val Glu Ala Ile Gly Leu Gly Tyr Asn Pro Phe Leu Gly 
        35                  40                  45              
Tyr Ala Gly Val Gly Ser Gly Thr Val Gln Leu Phe Asp Trp Asn Asn 
    50                  55                  60                  
Ala Lys Lys Lys Lys Val Ser Phe Lys Pro Glu Phe Val Val Pro Glu 
65                  70                  75                  80  
Ile Val Asp Val Gln Gln Asn Asp Ser Ala Thr Tyr Thr Asn Ile Ser 
                85                  90                  95      
Gly Asn Thr Val Thr Glu Tyr Gln Arg Ser Leu Ala Val Ser Val Ala 
            100                 105                 110         
Ile Glu Gly Lys Tyr Asn Phe Phe Ser Gly Ser Leu Ser Thr Asp Tyr 
        115                 120                 125             
Asp Glu Asn Ser Leu Arg Asn Ala Glu Asn Glu Phe Thr Arg Ile Gln 
    130                 135                 140                 
Gln Ser Ile Asn Leu Trp Ser Leu Arg Leu Pro Ser Val Lys Ser Leu 
145                 150                 155                 160 
Arg Asp Leu Met Leu Pro His Met Arg Glu Gln Leu Asp Glu Leu Asp 
                165                 170                 175     
Val Lys Asn Pro Ser Ala Ile Ser Arg Phe Phe Asp Arg Val Gly Ser 
            180                 185                 190         
His Phe Leu Thr Gly Ile Val Met Gly Gly Arg Ala Ile Leu Ala Ser 
        195                 200                 205             
Ser Thr Asn Lys Leu Lys Val Lys Arg Asp Tyr Ser Val Ser Val Ile 
    210                 215                 220                 
Ala Lys Ala Ser Tyr Glu Gly Leu Thr Gly Gln Leu Ser Ala Glu Ala 
225                 230                 235                 240 
Arg Thr Lys Tyr Gly Glu Ser Met Ser Ser Phe Thr Gln Tyr Ser Ser 
                245                 250                 255     
Thr His Gln Glu Val Arg Gly Gly Asp Gly Thr Lys Ala His Gly Val 
            260                 265                 270         
Phe Glu Gly Lys Ala Gly Phe Gln Ala Trp Val Asp Ser Val Ser Thr 
        275                 280                 285             
Ser Pro Asp Phe Val Asp Phe Val Pro Thr Ile Pro Met Gln Glu Ile 
    290                 295                 300                 
Trp Thr Leu Cys Ser Ser Glu Ala Gln Ala Glu Ala Met Arg Lys His 
305                 310                 315                 320 
Tyr Asp Asp Val Trp Ala Arg Glu Gln Ser Asp Lys Tyr Arg Ile Lys 
                325                 330                 335     
Ala Asn Tyr Ile Asp Gln Leu Val Val Ile Thr Gly Asp Ser Ser Thr 
            340                 345                 350         
Ile Glu Pro Pro Val Gly Tyr Ser Lys Ile Glu Tyr Asp Leu Asn Ala 
        355                 360                 365             
Gly Ala Lys Gly Asp Phe Ile Tyr Leu Cys Tyr His Glu Gln Ala Trp 
    370                 375                 380                 
Tyr Pro Asp Asn Thr Lys Pro Ala Val Thr Ala Ile Lys Ile Ile Tyr 
385                 390                 395                 400 
Asp Arg Glu Pro Val Pro Thr Gly Tyr Ile Lys Leu Pro Gln Asp Leu 
                405                 410                 415     
Asn Lys Gly Ala Gly Gly Ala Asp Ile Tyr Leu Cys Tyr Lys Leu Glu 
            420                 425                 430         
Gly Tyr Asn Thr Asp Thr Ala Ile Asn Lys Val Thr Val Ile Gly Gly 
        435                 440                 445             
Asn Asn Ala Asp Ile Asn Ala Pro Tyr Gly Tyr Leu Lys Val Pro Gly 
    450                 455                 460                 
Asp Leu Asn Arg Gly Ala Gly Gly Asn Phe Ile Tyr Ala Cys Thr Phe 
465                 470                 475                 480 
Val Gly Lys 
            

<210>  131
<211>  483
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  131
Met Glu Asn Val Asp Leu Pro Gln Gly Leu Val Asn Phe Ser Thr Gln 
1               5                   10                  15      
His Leu Gln Leu Ile Arg Phe Lys Ala Gly Leu Asn Glu Thr Val Leu 
            20                  25                  30          
Pro Gly Val Glu Ala Ile Gly Leu Gly Tyr Asn Pro Ile Ile Ser Tyr 
        35                  40                  45              
Ala Ser Val Asn Ser Gly Ala Val Gln Leu Phe Asp Trp Ala Thr Ala 
    50                  55                  60                  
Lys Lys Arg Glu Val Pro Phe Lys Pro Glu Phe Val Val Pro Glu Ile 
65                  70                  75                  80  
Val Asp Val Gln Gln Asn Asp Ser Ala Thr Tyr Thr Asn Val Ser Gly 
                85                  90                  95      
Asn Thr Ile Ser Glu Tyr Gln Arg Ser Leu Ala Thr Ser Val Ala Ile 
            100                 105                 110         
Glu Gly Arg Tyr Asn Phe Phe Ser Gly Ser Leu Ser Thr Asp Phe Asp 
        115                 120                 125             
Ser Asn Ser Leu Arg Asn Ala Glu Asn Glu Phe Thr Arg Ile Gln Gln 
    130                 135                 140                 
Ser Ile Asn Leu Trp Ser Leu Arg Leu Pro Ser Val Lys Ser Leu Arg 
145                 150                 155                 160 
Glu Leu Met Leu Pro His Met Arg Gln Gln Leu Asp Glu Leu Asn Val 
                165                 170                 175     
Asn Asp Pro Lys Ala Ile Ser Arg Tyr Phe Asp Arg Val Gly Ser His 
            180                 185                 190         
Phe Leu Thr Gly Ile Val Met Gly Gly Arg Ala Ile Leu Ala Ala Ser 
        195                 200                 205             
Thr Asn Lys Leu Asn Val Lys Arg Asp Tyr Ser Val Ser Val Val Ala 
    210                 215                 220                 
Lys Ala Ser Tyr Glu Gly Leu Thr Gly Gln Leu Ser Ala Glu Ala Lys 
225                 230                 235                 240 
Ala Lys Tyr Gly Glu Ser Ile Ser Ser Phe Thr Gln Tyr Ser Asn Thr 
                245                 250                 255     
His Gln Glu Val Arg Gly Gly Asp Gly Ala Lys Ala His Gly Val Phe 
            260                 265                 270         
Ser Gly Lys Lys Glu Asp Phe Gln Ala Trp Val Asp Ser Val Gly Ala 
        275                 280                 285             
Ser Pro Asp Phe Val Asp Phe Val Pro Thr Ile Pro Met Leu Glu Ile 
    290                 295                 300                 
Trp Ser Leu Cys Lys Thr Asp Ser Gln Ala Glu Ala Met Lys Arg His 
305                 310                 315                 320 
Phe Asp Thr Val Trp Ala Arg Glu Gln Ser Asp Lys Tyr Arg Ile Lys 
                325                 330                 335     
Ala Asn Tyr Ile Asp Gln Leu Val Val Ile Thr Gly Asp Ser Ser Thr 
            340                 345                 350         
Ile Glu Pro Pro Ala Gly Tyr Thr Lys Ile Pro Tyr Asp Leu Asn Ala 
        355                 360                 365             
Gly Ala Lys Gly Asp Phe Ile Tyr Leu Cys Tyr His Glu Gln Ala Trp 
    370                 375                 380                 
Tyr Pro Asp Asn Thr Lys Pro Ala Val Thr Ala Ile Lys Ile Ile Tyr 
385                 390                 395                 400 
Asp Arg Glu Pro Val Pro Thr Gly Tyr Ile Lys Leu Pro Gln Asp Leu 
                405                 410                 415     
Asn Lys Gly Ala Gly Gly Ala Asp Ile Tyr Leu Cys Tyr Lys Leu Glu 
            420                 425                 430         
Gly Tyr Asn Thr Asp Thr Ala Ile Asn Lys Ile Thr Val Ile Ser Gly 
        435                 440                 445             
Asn Asn Pro Asp Ile Asn Ala Pro Tyr Gly Tyr Glu Lys Val Pro Gly 
    450                 455                 460                 
Asp Leu Asn Lys Gly Ala Lys Gly Asn Phe Ile Tyr Ala Cys Thr Phe 
465                 470                 475                 480 
Val Gly Lys 
            

<210>  132
<211>  483
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  132
Met Glu His Val Asp Leu Pro Gln Gly Leu Val Asn Phe Ser Thr Gln 
1               5                   10                  15      
His Leu Gln Leu Ile Arg Phe Lys Ala Gly Leu Asn Glu Thr Val Leu 
            20                  25                  30          
Pro Gly Val Glu Ala Ile Gly Leu Gly Tyr Asn Pro Phe Ile Ser Tyr 
        35                  40                  45              
Ala Ser Val Asn Ser Gly Ala Val Gln Leu Phe Asp Trp Ala Thr Ala 
    50                  55                  60                  
Lys Lys Arg Glu Val Pro Phe Lys Ala Gly Tyr Phe Val Pro Glu Ile 
65                  70                  75                  80  
Val Asp Val Gln Gln Asn Asp Ser Ala Ser Tyr Thr Asn Val Ser Gly 
                85                  90                  95      
Asn Thr Ile Ser Glu Tyr Gln Arg Ser Leu Ala Thr Ser Val Ala Ile 
            100                 105                 110         
Glu Gly Arg Tyr Asn Phe Phe Ser Gly Ser Leu Ser Thr Asp Phe Asp 
        115                 120                 125             
Ser Asn Ser Leu Arg Asn Ala Glu Asn Glu Phe Thr Arg Ile Gln Gln 
    130                 135                 140                 
Ser Ile Asn Leu Trp Ser Leu Arg Leu Pro Ser Val Lys Ser Leu Arg 
145                 150                 155                 160 
Asp Leu Met Leu Pro His Met Arg Glu Gln Leu Asp Glu Leu Asp Val 
                165                 170                 175     
Lys Asn Pro Ser Ala Ile Ser Arg Phe Phe Asp Arg Val Gly Ser His 
            180                 185                 190         
Phe Leu Thr Gly Ile Val Met Gly Gly Arg Ala Ile Leu Ala Ala Ser 
        195                 200                 205             
Thr Asn Lys Leu Lys Val Lys Arg Asp Tyr Ser Val Ser Val Val Ala 
    210                 215                 220                 
Lys Ala Ser Tyr Glu Gly Leu Thr Gly Gln Leu Ser Ala Glu Ala Arg 
225                 230                 235                 240 
Thr Lys Tyr Gly Glu Ser Met Ser Ser Phe Thr Gln Tyr Ser Ser Thr 
                245                 250                 255     
His Gln Glu Val Arg Gly Gly Asp Gly Ala Lys Ala His Gly Val Phe 
            260                 265                 270         
Ser Gly Lys Lys Glu Asp Phe Gln Ala Trp Val Asp Ser Val Ser Ala 
        275                 280                 285             
Ser Pro Asp Phe Val Asp Phe Val Pro Thr Ile Pro Met Gln Glu Ile 
    290                 295                 300                 
Trp Thr Leu Cys Ser Ser Glu Ala Gln Ala Glu Ala Met Arg Lys His 
305                 310                 315                 320 
Tyr Asp Asp Val Trp Ala Pro Ala Gln Ser Glu Lys Tyr Arg Val Lys 
                325                 330                 335     
Ala Asn Tyr Ile Asp Gln Leu Val Val Ile Thr Gly Gly Ser Ser Thr 
            340                 345                 350         
Ile Glu Pro Pro Val Gly Tyr Ser Lys Ile Glu Tyr Asp Leu Asn Ala 
        355                 360                 365             
Gly Ala Gly Gly Asp Phe Ile Tyr Leu Cys Tyr His Glu Gln Thr Trp 
    370                 375                 380                 
Gln Ala Asp Arg Pro Lys Asp Ala Val Thr Asp Ile Arg Ile Ile Phe 
385                 390                 395                 400 
Asn Lys Glu Pro Thr Pro Pro Gly Tyr Thr Lys Leu Pro Gln Asp Leu 
                405                 410                 415     
Asn Lys Gly Ala Gly Gly Asp Asp Val Phe Leu Cys Tyr Lys Thr Glu 
            420                 425                 430         
Ala Tyr Asn Thr Asp Thr Ala Ile Asn Lys Val Thr Val Ile Gly Gly 
        435                 440                 445             
Asn Asn Ala Asp Ile Asn Ala Pro Tyr Gly Tyr Leu Lys Val Pro Gly 
    450                 455                 460                 
Asp Leu Asn Arg Gly Ala Gly Gly Asn Phe Ile Tyr Ala Cys Thr Phe 
465                 470                 475                 480 
Val Gly Lys 
            

<210>  133
<211>  482
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  133
Met Glu His Val Asp Leu Pro Gln Gly Leu Val Asn Phe Ser Thr Gln 
1               5                   10                  15      
His Leu Gln Leu Ile Arg Leu Lys Ala Gly Leu Asn Glu Thr Val Leu 
            20                  25                  30          
Pro Gly Val Glu Ala Ile Gly Leu Gly Tyr Asn Pro Phe Ile Ser Tyr 
        35                  40                  45              
Ala Ser Val Asn Ser Gly Ala Val Gln Leu Phe Asp Trp Ala Thr Ala 
    50                  55                  60                  
Lys Lys Arg Glu Val Pro Phe Lys Ala Gly Tyr Phe Val Pro Glu Ile 
65                  70                  75                  80  
Val Asp Val Gln Gln Asn Asp Ser Ala Thr Tyr Thr Asn Ile Ser Gly 
                85                  90                  95      
Asn Thr Val Thr Glu Tyr Gln Arg Ser Leu Ala Val Ser Val Ala Ile 
            100                 105                 110         
Glu Gly Lys Tyr Asn Phe Phe Ser Gly Ser Leu Ser Thr Asp Tyr Asp 
        115                 120                 125             
Glu Asn Ser Leu Arg Asn Ala Glu Asn Glu Phe Thr Arg Ile Gln Gln 
    130                 135                 140                 
Ser Ile Asn Leu Trp Ser Leu Arg Leu Pro Ser Val Lys Ser Leu Arg 
145                 150                 155                 160 
Glu Leu Met Leu Pro His Met Arg Gln Gln Leu Asp Glu Leu Asn Val 
                165                 170                 175     
Asn Asp Pro Lys Ala Ile Ser Arg Tyr Phe Asp Arg Val Gly Ser His 
            180                 185                 190         
Phe Leu Thr Gly Ile Val Met Gly Gly Arg Ala Ile Leu Ala Ser Ser 
        195                 200                 205             
Thr Asn Lys Leu Lys Val Lys Arg Asp Tyr Ser Val Ser Val Ile Ala 
    210                 215                 220                 
Lys Ala Ser Tyr Glu Gly Leu Thr Gly Gln Leu Ser Ala Glu Ala Arg 
225                 230                 235                 240 
Thr Lys Tyr Gly Glu Ser Met Ser Ser Phe Thr Gln Tyr Ser Ser Thr 
                245                 250                 255     
His Gln Glu Val Arg Gly Gly Asp Gly Thr Lys Ala His Gly Val Phe 
            260                 265                 270         
Glu Gly Lys Ala Gly Phe Gln Ala Trp Val Asp Ser Val Ser Ala Ser 
        275                 280                 285             
Pro Asp Phe Val Asp Phe Val Pro Thr Ile Pro Met Gln Glu Ile Trp 
    290                 295                 300                 
Thr Leu Cys Ser Cys Glu Ala Gln Ala Glu Ala Met Arg Lys His Tyr 
305                 310                 315                 320 
Asp Asp Val Trp Ala Pro Ala Gln Ser Glu Lys Tyr Arg Val Lys Ala 
                325                 330                 335     
Asn Tyr Ile Asp Gln Leu Val Val Ile Thr Gly Gly Ser Ser Thr Ile 
            340                 345                 350         
Glu Pro Pro Val Gly Tyr Ser Lys Ile Glu Tyr Asp Leu Asn Ala Gly 
        355                 360                 365             
Ala Gly Gly Asp Phe Ile Tyr Leu Cys Tyr His Glu Gln Thr Trp Gln 
    370                 375                 380                 
Ala Asp Arg Pro Lys Asp Ala Val Thr Asp Ile Arg Ile Ile Phe Asn 
385                 390                 395                 400 
Lys Glu Pro Thr Pro Pro Gly Tyr Thr Lys Leu Pro Gln Asp Leu Asn 
                405                 410                 415     
Lys Gly Ala Gly Gly Asp Asp Val Phe Leu Cys Tyr Lys Thr Glu Ala 
            420                 425                 430         
Tyr Asn Thr Asp Thr Ala Ile Asn Lys Ile Thr Val Ile Ser Gly Asn 
        435                 440                 445             
Asn Pro Asp Ile Asn Ala Pro Tyr Gly Tyr Glu Lys Val Pro Gly Asp 
    450                 455                 460                 
Leu Asn Lys Gly Ala Lys Gly Asn Phe Ile Tyr Ala Cys Thr Phe Val 
465                 470                 475                 480 
Gly Lys 
        

<210>  134
<211>  483
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  134
Met Glu Asn Ile Asp Leu Pro Thr Gly Leu Val Lys Phe Ser Ser Asn 
1               5                   10                  15      
His His Leu Gln Leu Leu Arg Asp Thr Ala Asp Leu Ser Glu Ser Val 
            20                  25                  30          
Leu Pro Gly Val Glu Ala Ile Gly Leu Gly Tyr Asn Pro Phe Leu Gly 
        35                  40                  45              
Tyr Ala Gly Val Gly Ser Gly Thr Val Gln Leu Phe Asp Trp Asn Asn 
    50                  55                  60                  
Ala Lys Lys Lys Lys Val Ser Phe Lys Pro Glu Phe Val Val Pro Glu 
65                  70                  75                  80  
Ile Val Asp Val Gln Gln Asn Asp Ser Ala Thr Tyr Thr Asn Val Ser 
                85                  90                  95      
Gly Asn Thr Ile Ser Glu Tyr Gln Arg Ser Leu Ala Thr Ser Val Ala 
            100                 105                 110         
Ile Glu Gly Arg Tyr Asn Phe Phe Ser Gly Ser Leu Ser Thr Asp Phe 
        115                 120                 125             
Asp Ser Asn Ser Leu Arg Asn Ala Glu Asn Glu Phe Thr Arg Ile Gln 
    130                 135                 140                 
Gln Ser Ile Asn Leu Trp Ser Leu Arg Leu Pro Ser Val Lys Ser Leu 
145                 150                 155                 160 
Arg Asp Leu Met Leu Pro His Met Arg Glu Gln Leu Asp Glu Leu Asp 
                165                 170                 175     
Val Lys Asn Pro Ser Ala Ile Ser Arg Phe Phe Asp Arg Val Gly Ser 
            180                 185                 190         
His Phe Leu Thr Gly Ile Val Met Gly Gly Arg Ala Ile Leu Ala Ala 
        195                 200                 205             
Ser Thr Asn Lys Leu Lys Val Lys Arg Asp Tyr Ser Val Ser Val Ile 
    210                 215                 220                 
Ala Lys Ala Ser Tyr Glu Gly Leu Thr Gly Gln Leu Ser Ala Glu Ala 
225                 230                 235                 240 
Arg Thr Lys Tyr Gly Glu Ser Met Ser Ser Phe Thr Gln Tyr Ser Arg 
                245                 250                 255     
Thr His Gln Glu Val Arg Gly Gly Asp Gly Thr Lys Ala His Gly Val 
            260                 265                 270         
Phe Glu Gly Lys Ala Gly Phe Gln Ala Trp Val Asp Ser Val Ser Ala 
        275                 280                 285             
Ser Pro Asp Phe Val Asp Phe Val Pro Thr Ile Pro Met Leu Glu Ile 
    290                 295                 300                 
Trp Ser Leu Cys Lys Thr Asp Ser Gln Ala Glu Ala Met Lys Arg His 
305                 310                 315                 320 
Phe Asp Thr Val Trp Ala Arg Glu Gln Ser Asp Lys Tyr Arg Ile Lys 
                325                 330                 335     
Ala Asn Tyr Ile Asp Gln Leu Val Val Ile Thr Gly Asp Ser Ser Thr 
            340                 345                 350         
Ile Glu Pro Pro Ala Gly Tyr Thr Lys Ile Pro Tyr Asp Leu Asn Ala 
        355                 360                 365             
Gly Ala Gly Gly Asp Phe Ile Tyr Leu Cys Tyr His Glu Gln Ala Trp 
    370                 375                 380                 
Tyr Pro Asp Asn Thr Lys Pro Ala Val Thr Ala Ile Lys Ile Ile Tyr 
385                 390                 395                 400 
Asp Arg Glu Pro Val Pro Thr Gly Tyr Ile Lys Leu Pro Gln Asp Leu 
                405                 410                 415     
Asn Lys Gly Ala Gly Gly Ala Asp Ile Tyr Leu Cys Tyr Lys Leu Glu 
            420                 425                 430         
Gly Tyr Asn Thr Asp Thr Ala Ile Asn Lys Val Thr Val Ile Gly Gly 
        435                 440                 445             
Asn Asn Ala Asp Ile Asn Ala Pro Tyr Gly Tyr Leu Lys Val Pro Gly 
    450                 455                 460                 
Asp Leu Asn Arg Gly Ala Gly Gly Asn Phe Ile Tyr Ala Cys Thr Phe 
465                 470                 475                 480 
Val Gly Lys 
            

<210>  135
<211>  483
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  135
Met Glu Asn Ile Asp Leu Pro Gln Gly Leu Val Asn Phe Ser Thr Gln 
1               5                   10                  15      
His Leu Gln Leu Ile Arg Phe Lys Ala Gly Leu Asn Glu Thr Val Leu 
            20                  25                  30          
Pro Gly Val Glu Ala Ile Gly Leu Gly Tyr Asn Pro Phe Ile Ser Tyr 
        35                  40                  45              
Ala Ser Val Asn Ser Gly Ala Val Gln Leu Phe Asp Trp Ala Thr Ala 
    50                  55                  60                  
Lys Lys Arg Glu Val Pro Phe Lys Ala Gly Tyr Phe Val Pro Glu Ile 
65                  70                  75                  80  
Val Asp Val Gln Gln Asn Asp Ser Ala Thr Tyr Thr Asn Val Ser Gly 
                85                  90                  95      
Asn Thr Ile Ser Glu Tyr Gln Arg Ser Leu Ala Thr Ser Val Ala Ile 
            100                 105                 110         
Glu Gly Arg Tyr Asn Phe Phe Ser Gly Ser Leu Ser Thr Asp Phe Asp 
        115                 120                 125             
Ser Asn Ser Leu Arg Asn Ala Glu Asn Glu Phe Thr Arg Ile Gln Gln 
    130                 135                 140                 
Ser Ile Asn Leu Trp Ser Leu Arg Leu Pro Ser Val Lys Ser Leu Arg 
145                 150                 155                 160 
Glu Leu Met Leu Pro His Met Arg Gln Gln Leu Asp Glu Leu Asn Val 
                165                 170                 175     
Asn Asp Pro Lys Ala Ile Ser Arg Tyr Phe Asp Arg Val Gly Ser His 
            180                 185                 190         
Phe Leu Thr Gly Ile Val Met Gly Gly Arg Ala Ile Leu Ala Ser Ser 
        195                 200                 205             
Thr Asn Lys Leu Arg Val Lys Arg Asp Tyr Ser Val Ser Val Val Ala 
    210                 215                 220                 
Lys Ala Ser Tyr Glu Gly Leu Thr Gly Gln Leu Ser Ala Glu Ala Arg 
225                 230                 235                 240 
Thr Lys Tyr Gly Glu Ser Met Ser Ser Phe Thr Gln Tyr Ser Asn Thr 
                245                 250                 255     
His Gln Glu Val Arg Gly Gly Asp Gly Ala Lys Ala His Gly Val Phe 
            260                 265                 270         
Ser Gly Lys Lys Glu Asp Phe Gln Ala Trp Val Asp Ser Val Ser Ala 
        275                 280                 285             
Ser Pro Asp Phe Val Asp Phe Val Pro Thr Ile Pro Met Gln Glu Ile 
    290                 295                 300                 
Trp Thr Leu Cys Ser Ser Glu Ala Gln Ala Glu Ala Met Arg Lys His 
305                 310                 315                 320 
Tyr Asp Asp Val Trp Ala Pro Ala Gln Ser Glu Lys Tyr Arg Val Lys 
                325                 330                 335     
Ala Asn Tyr Ile Asp Gln Leu Val Val Ile Thr Gly Asp Ser Ser Thr 
            340                 345                 350         
Ile Glu Pro Pro Ala Gly Tyr Thr Lys Ile Pro Tyr Asp Leu Asn Ala 
        355                 360                 365             
Gly Ala Lys Gly Asp Phe Ile Tyr Leu Cys Tyr His Glu Gln Ala Trp 
    370                 375                 380                 
Tyr Pro Asp Asn Thr Lys Pro Ala Val Thr Asp Ile Arg Ile Ile Phe 
385                 390                 395                 400 
Asn Lys Glu Pro Thr Pro Pro Gly Tyr Thr Lys Leu Pro Gln Asp Leu 
                405                 410                 415     
Asn Lys Gly Ala Gly Gly Asp Asp Val Phe Leu Cys Tyr Lys Thr Glu 
            420                 425                 430         
Ala Tyr Asn Thr Asp Thr Ala Ile Asn Lys Val Thr Val Ile Gly Gly 
        435                 440                 445             
Asn Asn Ala Asp Ile Asn Ala Pro Tyr Gly Tyr Glu Lys Val Pro Gly 
    450                 455                 460                 
Asp Leu Asn Arg Gly Ala Gly Gly Asn Phe Ile Tyr Ala Cys Thr Phe 
465                 470                 475                 480 
Val Gly Lys 
            

<210>  136
<211>  483
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  136
Met Glu Asn Ile Asp Leu Pro Gln Gly Leu Val Asn Phe Ser Thr Gln 
1               5                   10                  15      
His Leu Gln Leu Ile Arg Phe Lys Ala Gly Leu Asn Glu Thr Val Leu 
            20                  25                  30          
Pro Gly Val Glu Ala Ile Gly Leu Gly Tyr Asn Pro Phe Ile Ser Tyr 
        35                  40                  45              
Ala Ser Val Asn Ser Gly Ala Val Gln Leu Phe Asp Trp Ala Thr Ala 
    50                  55                  60                  
Lys Lys Arg Glu Val Pro Phe Lys Ala Gly Tyr Phe Val Pro Glu Ile 
65                  70                  75                  80  
Val Asp Val Gln Gln Asn Asp Ser Ala Ser Tyr Thr Asn Ile Ser Gly 
                85                  90                  95      
Asn Thr Val Thr Glu Tyr Gln Arg Ser Leu Ala Val Ser Val Ala Ile 
            100                 105                 110         
Glu Gly Lys Tyr Asn Phe Phe Ser Gly Ser Leu Ser Thr Asp Tyr Asp 
        115                 120                 125             
Glu Asn Ser Leu Arg Asn Ala Glu Asn Glu Phe Thr Arg Ile Gln Gln 
    130                 135                 140                 
Ser Ile Asn Leu Trp Ser Leu Arg Leu Pro Ser Val Lys Ser Leu Arg 
145                 150                 155                 160 
Asp Leu Met Leu Pro His Met Arg Glu Gln Leu Asp Glu Leu Asp Val 
                165                 170                 175     
Lys Asn Pro Ser Ala Ile Ser Arg Phe Phe Asp Arg Val Gly Ser His 
            180                 185                 190         
Phe Leu Thr Gly Ile Val Met Gly Gly Arg Ala Ile Leu Ala Ser Ser 
        195                 200                 205             
Thr Asn Lys Leu Arg Val Lys Arg Asp Tyr Ser Val Ser Val Val Ala 
    210                 215                 220                 
Lys Ala Ser Tyr Glu Gly Leu Thr Gly Gln Leu Ser Ala Glu Ala Lys 
225                 230                 235                 240 
Ala Lys Tyr Gly Glu Ser Ile Ser Ser Phe Thr Gln Tyr Ser Asn Thr 
                245                 250                 255     
His Gln Glu Val Arg Gly Gly Asp Gly Ala Lys Ala His Gly Val Phe 
            260                 265                 270         
Ser Gly Lys Lys Glu Asp Phe Gln Ala Trp Val Asp Ser Val Ser Ala 
        275                 280                 285             
Ser Pro Asp Phe Val Asp Phe Val Pro Thr Ile Pro Met Leu Glu Ile 
    290                 295                 300                 
Trp Ser Leu Cys Lys Thr Asp Ser Gln Ala Glu Ala Met Lys Arg His 
305                 310                 315                 320 
Phe Asp Thr Val Trp Ala Arg Glu Gln Ser Asp Lys Tyr Arg Ile Lys 
                325                 330                 335     
Ala Asn Tyr Ile Asp Gln Leu Val Val Ile Thr Gly Gly Ser Ser Thr 
            340                 345                 350         
Ile Glu Pro Pro Val Gly Tyr Thr Lys Ile Pro Tyr Asp Leu Asn Ala 
        355                 360                 365             
Gly Ala Lys Gly Asp Phe Ile Tyr Leu Cys Tyr His Glu Gln Ala Trp 
    370                 375                 380                 
Tyr Pro Asp Asn Thr Lys Pro Ala Val Thr Ala Ile Lys Ile Ile Tyr 
385                 390                 395                 400 
Asp Arg Glu Pro Val Pro Thr Gly Tyr Thr Lys Leu Pro Gln Asp Leu 
                405                 410                 415     
Asn Lys Gly Ala Gly Gly Asp Asp Val Phe Leu Cys Tyr Lys Thr Glu 
            420                 425                 430         
Ala Tyr Asn Thr Asp Thr Ala Ile Asn Lys Val Thr Val Ile Gly Gly 
        435                 440                 445             
Asn Asn Ala Asp Ile Asn Ala Pro Tyr Gly Tyr Leu Lys Val Pro Gly 
    450                 455                 460                 
Asp Leu Asn Arg Gly Ala Gly Gly Asn Phe Ile Tyr Ala Cys Thr Phe 
465                 470                 475                 480 
Val Gly Lys 
            

<210>  137
<211>  482
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  137
Met Glu Asn Ile Asp Leu Pro Gln Gly Leu Val Asn Phe Ser Thr Gln 
1               5                   10                  15      
His Leu Gln Leu Ile Arg Phe Lys Ala Gly Leu Asn Glu Thr Val Leu 
            20                  25                  30          
Pro Gly Val Glu Ala Ile Gly Leu Gly Tyr Asn Pro Phe Ile Ser Tyr 
        35                  40                  45              
Ala Ser Val Asn Ser Gly Ala Val Gln Leu Phe Asp Trp Ala Thr Ala 
    50                  55                  60                  
Lys Lys Arg Glu Val Pro Phe Lys Ala Gly Tyr Phe Val Pro Glu Ile 
65                  70                  75                  80  
Val Asp Val Gln Gln Asn Asp Ser Ala Ser Tyr Thr Asn Ile Ser Gly 
                85                  90                  95      
Asn Thr Val Thr Glu Tyr Gln Arg Ser Leu Ala Val Ser Val Ala Ile 
            100                 105                 110         
Glu Gly Lys Tyr Asn Phe Phe Ser Gly Ser Leu Ser Thr Asp Tyr Asp 
        115                 120                 125             
Glu Asn Ser Leu Arg Asn Ala Glu Asn Glu Phe Thr Arg Ile Gln Gln 
    130                 135                 140                 
Ser Ile Asn Leu Trp Ser Leu Arg Leu Pro Ser Val Lys Ser Leu Arg 
145                 150                 155                 160 
Asp Leu Met Leu Pro His Met Arg Glu Gln Leu Asp Glu Leu Asp Val 
                165                 170                 175     
Lys Asn Pro Ser Ala Ile Ser Arg Phe Phe Asp Arg Val Gly Ser His 
            180                 185                 190         
Phe Leu Thr Gly Ile Val Met Gly Gly Arg Ala Ile Leu Ala Ser Ser 
        195                 200                 205             
Thr Asn Lys Leu Arg Val Lys Arg Asp Tyr Ser Val Ser Val Val Ala 
    210                 215                 220                 
Lys Ala Ser Tyr Glu Gly Leu Thr Gly Gln Leu Ser Ala Glu Ala Arg 
225                 230                 235                 240 
Thr Lys Tyr Gly Glu Ser Met Ser Ser Phe Thr Gln Tyr Ser Ser Thr 
                245                 250                 255     
His Gln Glu Val Arg Gly Gly Asp Gly Thr Lys Ala His Gly Val Phe 
            260                 265                 270         
Glu Gly Lys Ala Gly Phe Gln Ala Trp Val Asp Ser Val Gly Thr Ser 
        275                 280                 285             
Pro Asp Phe Val Asp Phe Val Pro Thr Ile Pro Met Gln Glu Ile Trp 
    290                 295                 300                 
Thr Leu Cys Lys Thr Asp Ser Gln Ala Glu Ala Met Lys Arg His Phe 
305                 310                 315                 320 
Asp Thr Val Trp Ala Arg Glu Gln Ser Asp Lys Tyr Arg Ile Lys Ala 
                325                 330                 335     
Asn Tyr Ile Asp Gln Leu Val Val Ile Thr Gly Asp Ser Ser Thr Ile 
            340                 345                 350         
Glu Pro Pro Ala Gly Tyr Thr Lys Ile Glu Tyr Asp Leu Asn Ala Gly 
        355                 360                 365             
Ala Lys Gly Asp Phe Ile Tyr Leu Cys Tyr His Glu Gln Ala Trp Tyr 
    370                 375                 380                 
Pro Asp Asn Thr Lys Pro Ala Val Thr Ala Ile Lys Ile Ile Phe Asn 
385                 390                 395                 400 
Lys Glu Pro Thr Pro Pro Gly Tyr Thr Lys Leu Pro Gln Asp Leu Asn 
                405                 410                 415     
Lys Gly Ala Gly Gly Asp Asp Val Phe Leu Cys Tyr Lys Thr Glu Ala 
            420                 425                 430         
Tyr Asn Thr Asp Thr Ala Ile Asn Lys Val Thr Val Ile Gly Gly Asn 
        435                 440                 445             
Asn Ala Asp Ile Asn Ala Pro Tyr Gly Tyr Leu Lys Val Pro Gly Asp 
    450                 455                 460                 
Leu Asn Arg Gly Ala Gly Gly Asn Phe Ile Tyr Ala Cys Thr Phe Val 
465                 470                 475                 480 
Gly Lys 
        

<210>  138
<211>  484
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  138
Met Glu His Val Asp Leu Pro Thr Gly Leu Val Lys Phe Ser Ser Asn 
1               5                   10                  15      
His His Leu Gln Leu Leu Arg Asp Thr Ala Asp Leu Ser Glu Ser Val 
            20                  25                  30          
Leu Pro Gly Val Glu Ala Ile Gly Leu Gly Tyr Asn Pro Phe Leu Gly 
        35                  40                  45              
Tyr Ala Gly Val Gly Ser Gly Thr Val Gln Leu Phe Asp Trp Asn Asn 
    50                  55                  60                  
Ala Lys Lys Lys Lys Val Ser Phe Lys Pro Glu Phe Val Val Pro Glu 
65                  70                  75                  80  
Ile Val Asp Val Gln Gln Asn Asp Ser Ala Ser Tyr Thr Asn Ile Ser 
                85                  90                  95      
Gly Asn Thr Val Thr Glu Tyr Gln Arg Ser Leu Ala Val Ser Val Ala 
            100                 105                 110         
Ile Glu Gly Lys Tyr Asn Phe Phe Ser Gly Ser Leu Ser Thr Asp Tyr 
        115                 120                 125             
Asp Glu Asn Ser Leu Arg Asn Ala Glu Asn Glu Phe Thr Arg Ile Gln 
    130                 135                 140                 
Gln Ser Ile Asn Leu Trp Ser Leu Arg Leu Pro Ser Val Lys Ser Leu 
145                 150                 155                 160 
Arg Glu Leu Met Leu Pro His Met Arg Gln Gln Leu Asp Glu Leu Asn 
                165                 170                 175     
Val Asn Asp Pro Lys Ala Ile Ser Arg Tyr Phe Asp Arg Val Gly Ser 
            180                 185                 190         
His Phe Leu Thr Gly Ile Val Met Gly Gly Arg Ala Ile Leu Ala Ala 
        195                 200                 205             
Ser Thr Asn Lys Leu Arg Val Lys Arg Asp Tyr Ser Val Ser Val Val 
    210                 215                 220                 
Ala Lys Ala Ser Tyr Glu Gly Leu Thr Gly Gln Leu Ser Ala Glu Ala 
225                 230                 235                 240 
Arg Thr Lys Tyr Gly Glu Ser Met Ser Ser Phe Thr Gln Tyr Ser Ser 
                245                 250                 255     
Thr His Gln Glu Val Arg Gly Gly Asp Gly Ala Lys Ala His Gly Val 
            260                 265                 270         
Phe Ser Gly Lys Lys Glu Asp Phe Gln Ala Trp Val Asp Ser Val Gly 
        275                 280                 285             
Thr Ser Ser Asp Phe Val Asp Phe Val Pro Thr Ile Pro Met Leu Lys 
    290                 295                 300                 
Ile Trp Ser Leu Cys Lys Thr Asp Ser Gln Ala Glu Ala Met Lys Arg 
305                 310                 315                 320 
His Phe Asp Thr Val Trp Ala Arg Glu Gln Ser Asp Lys Tyr Arg Ile 
                325                 330                 335     
Lys Ala Asn Tyr Ile Asp Gln Leu Val Val Ile Thr Gly Gly Ser Ser 
            340                 345                 350         
Thr Ile Glu Pro Pro Val Gly Tyr Ser Lys Ile Glu Tyr Asp Leu Asn 
        355                 360                 365             
Ala Gly Ala Gly Gly Asp Phe Ile Tyr Leu Cys Tyr His Glu Gln Thr 
    370                 375                 380                 
Trp Gln Ala Asp Arg Pro Lys Asp Ala Val Thr Asp Ile Arg Ile Ile 
385                 390                 395                 400 
Phe Asn Lys Glu Pro Thr Pro Pro Gly Tyr Thr Lys Leu Pro Gln Asp 
                405                 410                 415     
Leu Asn Lys Gly Ala Gly Gly Asp Asp Val Phe Leu Cys Tyr Lys Thr 
            420                 425                 430         
Glu Ala Tyr Asn Thr Asp Thr Ala Ile Asn Lys Val Thr Val Ile Gly 
        435                 440                 445             
Gly Asn Asn Ala Asp Ile Asn Ala Pro Tyr Gly Tyr Leu Lys Val Pro 
    450                 455                 460                 
Gly Asp Leu Asn Arg Gly Ala Gly Gly Asn Phe Ile Tyr Ala Cys Thr 
465                 470                 475                 480 
Phe Val Gly Lys 
                

<210>  139
<211>  483
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  139
Met Glu His Val Asp Leu Pro Thr Gly Leu Val Lys Phe Ser Ser Asn 
1               5                   10                  15      
His His Leu Gln Leu Leu Arg Asp Thr Ala Asp Leu Ser Glu Ser Val 
            20                  25                  30          
Leu Pro Gly Val Glu Ala Ile Gly Leu Gly Tyr Asn Pro Phe Leu Gly 
        35                  40                  45              
Tyr Ala Gly Val Gly Ser Gly Thr Val Gln Leu Phe Asp Trp Asn Asn 
    50                  55                  60                  
Ala Lys Lys Lys Lys Val Ser Phe Lys Pro Glu Phe Val Val Pro Glu 
65                  70                  75                  80  
Ile Val Asp Val Gln Gln Asn Asp Ser Ala Ser Tyr Thr Asn Ile Ser 
                85                  90                  95      
Gly Asn Thr Ile Ser Glu Tyr Gln Arg Ser Leu Ala Thr Ser Val Ala 
            100                 105                 110         
Ile Glu Gly Arg Tyr Asn Phe Phe Ser Gly Ser Leu Ser Thr Asp Phe 
        115                 120                 125             
Asp Ser Asn Ser Leu Arg Asn Ala Glu Asn Glu Phe Thr Arg Ile Gln 
    130                 135                 140                 
Gln Ser Ile Asn Leu Trp Ser Leu Arg Leu Pro Ser Val Lys Ser Leu 
145                 150                 155                 160 
Arg Glu Leu Met Leu Pro His Met Arg Gln Gln Leu Asp Glu Leu Asn 
                165                 170                 175     
Val Asn Asp Pro Lys Ala Ile Ser Arg Tyr Phe Asp Arg Val Gly Ser 
            180                 185                 190         
His Phe Leu Thr Gly Ile Val Met Gly Gly Arg Ala Ile Leu Ala Ser 
        195                 200                 205             
Ser Thr Asn Lys Leu Arg Val Lys Arg Asp Tyr Ser Val Ser Val Val 
    210                 215                 220                 
Ala Lys Ala Ser Tyr Glu Gly Leu Thr Gly Gln Leu Ser Ala Glu Ala 
225                 230                 235                 240 
Arg Thr Lys Tyr Gly Glu Ser Met Ser Ser Phe Thr Gln Tyr Ser Ser 
                245                 250                 255     
Thr His Gln Glu Val Arg Gly Gly Asp Gly Thr Lys Ala His Gly Val 
            260                 265                 270         
Phe Glu Gly Lys Ala Gly Phe Gln Ala Trp Val Asp Ser Val Gly Thr 
        275                 280                 285             
Ser Pro Asp Phe Val Asp Phe Val Pro Thr Ile Pro Met Leu Glu Ile 
    290                 295                 300                 
Trp Ser Leu Cys Lys Thr Asp Ser Gln Ala Glu Ala Met Lys Arg His 
305                 310                 315                 320 
Phe Asp Thr Val Trp Ala Arg Glu Gln Ser Asp Lys Tyr Arg Ile Lys 
                325                 330                 335     
Ala Asn Tyr Ile Asp Gln Leu Val Val Ile Thr Gly Gly Ser Ser Thr 
            340                 345                 350         
Ile Glu Pro Pro Val Gly Tyr Ser Lys Ile Glu Tyr Asp Leu Asn Ala 
        355                 360                 365             
Gly Ala Gly Gly Asp Phe Ile Tyr Leu Cys Tyr His Glu Gln Thr Trp 
    370                 375                 380                 
Gln Ala Asp Arg Pro Lys Asp Ala Val Thr Asp Ile Arg Ile Ile Phe 
385                 390                 395                 400 
Asn Lys Glu Pro Thr Pro Pro Gly Tyr Thr Lys Leu Pro Gln Asp Leu 
                405                 410                 415     
Asn Lys Gly Ala Gly Gly Asp Asp Val Phe Leu Cys Tyr Lys Thr Glu 
            420                 425                 430         
Ala Tyr Asn Thr Asp Thr Ala Ile Asn Lys Val Thr Val Ile Gly Gly 
        435                 440                 445             
Asn Asn Ala Asp Ile Asn Ala Pro Tyr Gly Tyr Leu Lys Val Pro Gly 
    450                 455                 460                 
Asp Leu Asn Lys Gly Ala Lys Gly Asn Phe Ile Tyr Ala Cys Thr Phe 
465                 470                 475                 480 
Val Gly Lys 
            

<210>  140
<211>  482
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  140
Met Glu Asn Ile Asp Leu Pro Gln Gly Leu Val Asn Phe Ser Thr Gln 
1               5                   10                  15      
His Leu Gln Leu Ile Arg Phe Lys Ala Gly Leu Asn Glu Thr Val Leu 
            20                  25                  30          
Pro Gly Val Glu Ala Ile Gly Leu Gly Tyr Asn Pro Phe Ile Ser Tyr 
        35                  40                  45              
Ala Ser Val Asn Ser Gly Thr Val Gln Leu Phe Asp Trp Ala Thr Ala 
    50                  55                  60                  
Lys Lys Arg Glu Val Pro Phe Lys Ala Gly Tyr Phe Val Pro Glu Ile 
65                  70                  75                  80  
Val Asp Val Gln Gln Asn Asp Ser Ala Thr Tyr Thr Asn Val Ser Gly 
                85                  90                  95      
Asn Thr Ile Ser Glu Tyr Gln Arg Ser Leu Ala Thr Ser Val Ala Ile 
            100                 105                 110         
Glu Gly Arg Tyr Asn Phe Phe Ser Gly Ser Leu Ser Thr Asp Phe Asp 
        115                 120                 125             
Ser Asn Ser Leu Arg Asn Ala Glu Asn Glu Phe Thr Arg Ile Gln Gln 
    130                 135                 140                 
Ser Ile Asn Leu Trp Ser Leu Arg Leu Pro Ser Val Lys Ser Leu Arg 
145                 150                 155                 160 
Asp Leu Met Leu Pro His Met Arg Glu Gln Leu Asp Glu Leu Asp Val 
                165                 170                 175     
Lys Asn Pro Ser Ala Ile Ser Arg Phe Phe Asp Arg Val Gly Ser His 
            180                 185                 190         
Phe Leu Thr Gly Ile Val Met Gly Gly Arg Ala Ile Leu Ala Ser Ser 
        195                 200                 205             
Thr Asn Lys Leu Arg Val Lys Arg Asp Tyr Ser Val Ser Val Val Ala 
    210                 215                 220                 
Lys Ala Ser Tyr Glu Gly Leu Thr Gly Gln Leu Ser Ala Glu Ala Arg 
225                 230                 235                 240 
Thr Lys Tyr Gly Glu Ser Met Ser Ser Phe Thr Gln Tyr Ser Ser Thr 
                245                 250                 255     
His Gln Glu Val Arg Gly Gly Asp Gly Thr Lys Ala His Gly Val Phe 
            260                 265                 270         
Glu Gly Lys Ala Gly Phe Gln Ala Trp Val Asp Ser Val Gly Thr Ser 
        275                 280                 285             
Pro Asp Phe Val Asp Phe Val Pro Thr Ile Pro Met Leu Glu Ile Trp 
    290                 295                 300                 
Ser Leu Cys Lys Thr Asp Ser Gln Ala Glu Ala Met Lys Arg His Phe 
305                 310                 315                 320 
Asp Thr Val Trp Ala Arg Glu Gln Ser Asp Lys Tyr Arg Ile Lys Ala 
                325                 330                 335     
Asn Tyr Ile Asp Gln Leu Val Val Ile Thr Gly Asp Ser Ser Thr Ile 
            340                 345                 350         
Glu Pro Pro Ala Gly Tyr Thr Lys Ile Pro Tyr Asp Leu Asn Ala Gly 
        355                 360                 365             
Ala Gly Gly Asp Phe Ile Tyr Leu Cys Tyr His Glu Gln Thr Trp Gln 
    370                 375                 380                 
Ala Asp Arg Pro Lys Asp Ala Val Thr Asp Ile Lys Ile Ile Tyr Asp 
385                 390                 395                 400 
Arg Glu Pro Val Pro Thr Gly Tyr Ile Lys Leu Pro Gln Asp Leu Asn 
                405                 410                 415     
Lys Gly Ala Gly Gly Ala Asp Ile Tyr Leu Cys Tyr Lys Leu Glu Gly 
            420                 425                 430         
Tyr Asn Thr Asp Thr Ala Ile Asn Lys Val Thr Val Ile Gly Gly Asn 
        435                 440                 445             
Asn Ala Asp Ile Asn Ala Pro Tyr Gly Tyr Leu Lys Val Pro Gly Asp 
    450                 455                 460                 
Leu Asn Arg Gly Ala Gly Gly Asn Phe Ile Tyr Ala Cys Thr Phe Val 
465                 470                 475                 480 
Gly Lys 
        

<210>  141
<211>  483
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  141
Met Glu Asn Ile Asp Leu Pro Gln Gly Leu Val Asn Phe Ser Thr Gln 
1               5                   10                  15      
His Leu Gln Leu Ile Arg Phe Lys Ala Gly Leu Asn Glu Thr Val Leu 
            20                  25                  30          
Pro Gly Val Glu Ala Ile Gly Leu Gly Tyr Asn Pro Phe Ile Ser Tyr 
        35                  40                  45              
Ala Ser Val Asn Ser Gly Ala Val Gln Leu Phe Asp Trp Ala Thr Ala 
    50                  55                  60                  
Lys Lys Arg Glu Val Pro Phe Lys Ala Gly Tyr Phe Val Pro Glu Ile 
65                  70                  75                  80  
Val Asp Val Gln Gln Asn Asp Ser Ala Thr Tyr Thr Asn Val Ser Gly 
                85                  90                  95      
Asn Thr Ile Ser Glu Tyr Gln Arg Ser Leu Ala Thr Ser Val Ala Ile 
            100                 105                 110         
Glu Gly Arg Tyr Asn Phe Phe Ser Gly Ser Leu Ser Thr Asp Phe Asp 
        115                 120                 125             
Ser Asn Ser Leu Arg Asn Ala Glu Asn Glu Phe Thr Arg Ile Gln Gln 
    130                 135                 140                 
Ser Ile Asn Leu Trp Ser Leu Arg Leu Pro Ser Val Lys Ser Leu Arg 
145                 150                 155                 160 
Asp Leu Met Leu Pro His Met Arg Glu Gln Leu Asp Glu Leu Asp Val 
                165                 170                 175     
Lys Asn Pro Ser Ala Ile Ser Arg Phe Phe Asp Arg Val Gly Ser His 
            180                 185                 190         
Phe Leu Thr Gly Ile Val Met Gly Gly Arg Ala Ile Leu Ala Ser Ser 
        195                 200                 205             
Thr Asn Lys Leu Arg Val Lys Arg Asp Tyr Ser Val Ser Val Ile Ala 
    210                 215                 220                 
Lys Ala Ser Tyr Glu Gly Leu Thr Gly Gln Leu Ser Ala Glu Ala Arg 
225                 230                 235                 240 
Thr Lys Tyr Gly Glu Ser Met Ser Ser Phe Thr Gln Tyr Ser Asn Thr 
                245                 250                 255     
His Gln Glu Val Arg Gly Gly Asp Gly Ala Lys Ala His Gly Val Phe 
            260                 265                 270         
Ser Gly Lys Lys Glu Asp Phe Gln Ala Trp Val Asp Ser Val Ser Ala 
        275                 280                 285             
Ser Pro Asp Phe Val Asp Phe Val Pro Thr Ile Pro Met Gln Glu Ile 
    290                 295                 300                 
Trp Thr Leu Cys Ser Ser Glu Ala Gln Ala Glu Ala Met Arg Lys His 
305                 310                 315                 320 
Tyr Asp Asp Val Trp Ala Pro Ala Gln Ser Glu Lys Tyr Arg Val Lys 
                325                 330                 335     
Ala Asn Tyr Ile Asp Gln Leu Val Val Ile Thr Gly Gly Ser Ser Thr 
            340                 345                 350         
Ile Glu Pro Pro Val Gly Tyr Ser Lys Ile Glu Tyr Asp Leu Asn Ala 
        355                 360                 365             
Gly Ala Gly Gly Asp Phe Ile Tyr Leu Cys Tyr His Glu Gln Ala Trp 
    370                 375                 380                 
Tyr Pro Asp Asn Thr Lys Pro Ala Val Thr Ala Ile Lys Ile Ile Tyr 
385                 390                 395                 400 
Asp Arg Glu Pro Val Pro Thr Gly Tyr Ile Lys Leu Pro Gln Asp Leu 
                405                 410                 415     
Asn Lys Gly Ala Gly Gly Ala Asp Ile Tyr Leu Cys Tyr Lys Leu Glu 
            420                 425                 430         
Gly Tyr Asn Thr Asp Thr Ala Ile Asn Lys Val Thr Val Ile Gly Gly 
        435                 440                 445             
Asn Asn Pro Asp Ile Asn Ala Pro Tyr Gly Tyr Glu Lys Val Pro Gly 
    450                 455                 460                 
Asp Leu Asn Lys Gly Ala Lys Gly Asn Phe Ile Tyr Ala Cys Thr Phe 
465                 470                 475                 480 
Val Gly Lys 
            

<210>  142
<211>  484
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  142
Met Glu His Val Asp Leu Pro Thr Gly Leu Val Lys Phe Ser Ser Asn 
1               5                   10                  15      
His His Leu Gln Leu Leu Arg Asp Thr Ala Asp Leu Ser Glu Ser Val 
            20                  25                  30          
Leu Pro Gly Val Glu Ala Ile Gly Leu Gly Tyr Asn Pro Phe Leu Gly 
        35                  40                  45              
Tyr Ala Gly Val Gly Ser Gly Thr Val Gln Leu Phe Asp Trp Asn Asn 
    50                  55                  60                  
Ala Lys Lys Lys Lys Val Ser Phe Lys Pro Glu Phe Val Val Pro Glu 
65                  70                  75                  80  
Ile Val Asp Val Gln Gln Asn Asp Ser Ala Ser Tyr Thr Asn Ile Ser 
                85                  90                  95      
Gly Asn Thr Val Thr Glu Tyr Gln Arg Ser Leu Ala Val Ser Val Ala 
            100                 105                 110         
Ile Glu Gly Arg Tyr Asn Phe Phe Ser Gly Ser Leu Ser Thr Asp Phe 
        115                 120                 125             
Asp Ser Asn Ser Leu Arg Asn Ala Glu Asn Glu Phe Thr Arg Ile Gln 
    130                 135                 140                 
Gln Ser Ile Asn Leu Trp Ser Leu Arg Leu Pro Ser Val Lys Ser Leu 
145                 150                 155                 160 
Arg Glu Leu Met Leu Pro His Met Arg Gln Gln Leu Asp Glu Leu Asn 
                165                 170                 175     
Val Asn Asp Pro Lys Ala Ile Ser Arg Tyr Phe Asp Arg Val Gly Ser 
            180                 185                 190         
His Phe Leu Thr Gly Ile Val Met Gly Gly Arg Ala Ile Leu Ala Ala 
        195                 200                 205             
Ser Thr Asn Lys Leu Lys Val Lys Arg Asp Tyr Ser Val Ser Val Ile 
    210                 215                 220                 
Ala Lys Ala Ser Tyr Glu Gly Leu Thr Gly Gln Leu Ser Ala Glu Ala 
225                 230                 235                 240 
Lys Ala Lys Tyr Gly Glu Ser Ile Ser Ser Phe Thr Gln Tyr Ser Asn 
                245                 250                 255     
Thr His Gln Glu Val Arg Gly Gly Asp Gly Ala Lys Ala His Gly Val 
            260                 265                 270         
Phe Ser Gly Lys Lys Glu Asp Phe Gln Ala Trp Val Asp Ser Val Ser 
        275                 280                 285             
Ala Ser Pro Asp Phe Val Asp Phe Val Pro Thr Ile Pro Met Gln Glu 
    290                 295                 300                 
Ile Trp Thr Leu Cys Ser Ser Glu Ala Gln Ala Glu Ala Met Arg Lys 
305                 310                 315                 320 
His Tyr Asp Asp Val Trp Ala Pro Ala Gln Ser Glu Lys Tyr Arg Val 
                325                 330                 335     
Lys Ala Asn Tyr Ile Asp Gln Leu Val Val Ile Thr Gly Gly Ser Ser 
            340                 345                 350         
Thr Ile Glu Pro Pro Val Gly Tyr Ser Lys Ile Glu Tyr Asp Leu Asn 
        355                 360                 365             
Ala Gly Ala Gly Gly Asp Phe Ile Tyr Leu Cys Tyr His Glu Gln Thr 
    370                 375                 380                 
Trp Gln Ala Asp Arg Pro Lys Asp Ala Val Thr Asp Ile Arg Ile Ile 
385                 390                 395                 400 
Phe Asn Lys Glu Pro Thr Pro Pro Gly Tyr Ile Lys Leu Pro Gln Asp 
                405                 410                 415     
Leu Asn Lys Gly Ala Gly Gly Asp Asp Val Phe Leu Cys Tyr Lys Thr 
            420                 425                 430         
Glu Ala Tyr Asn Thr Asp Thr Ala Ile Asn Lys Val Thr Val Ile Gly 
        435                 440                 445             
Gly Asn Asn Pro Asp Ile Asn Ala Pro Tyr Gly Tyr Leu Lys Val Pro 
    450                 455                 460                 
Gly Asp Leu Asn Arg Gly Ala Gly Gly Asn Phe Ile Tyr Ala Cys Thr 
465                 470                 475                 480 
Phe Val Gly Lys 
                

<210>  143
<211>  482
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  143
Met Glu Asn Ile Asp Leu Pro Gln Gly Leu Val Asn Phe Ser Thr Gln 
1               5                   10                  15      
His Leu Gln Leu Ile Arg Phe Lys Ala Gly Leu Asn Glu Thr Val Leu 
            20                  25                  30          
Pro Gly Val Glu Ala Ile Gly Leu Gly Tyr Asn Pro Phe Ile Ser Tyr 
        35                  40                  45              
Ala Ser Val Asn Ser Gly Ala Val Gln Leu Phe Asp Trp Ala Thr Ala 
    50                  55                  60                  
Lys Lys Arg Glu Val Ser Phe Lys Pro Glu Phe Val Val Pro Glu Ile 
65                  70                  75                  80  
Val Asp Val Gln Gln Asn Asp Ser Ala Ser Tyr Thr Asn Ile Ser Gly 
                85                  90                  95      
Asn Thr Val Thr Glu Tyr Gln Arg Ser Leu Ala Thr Ser Val Ala Ile 
            100                 105                 110         
Glu Gly Arg Tyr Asn Phe Phe Ser Gly Ser Leu Ser Thr Asp Phe Asp 
        115                 120                 125             
Ser Asn Ser Leu Arg Asn Ala Glu Asn Glu Phe Thr Arg Ile Gln Gln 
    130                 135                 140                 
Ser Ile Asn Leu Trp Ser Leu Arg Leu Pro Ser Val Lys Ser Leu Arg 
145                 150                 155                 160 
Glu Leu Met Leu Pro His Met Arg Gln Gln Leu Asp Glu Leu Asn Val 
                165                 170                 175     
Asn Asp Pro Lys Ala Ile Ser Arg Tyr Phe Asp Arg Val Gly Ser His 
            180                 185                 190         
Phe Leu Thr Gly Ile Val Met Gly Gly Arg Ala Ile Leu Ala Ser Ser 
        195                 200                 205             
Thr Asn Lys Leu Arg Val Lys Arg Asp Tyr Ser Val Ser Val Val Ala 
    210                 215                 220                 
Lys Ala Ser Tyr Glu Gly Leu Thr Gly Gln Leu Ser Ala Glu Ala Lys 
225                 230                 235                 240 
Ala Lys Tyr Gly Glu Ser Ile Ser Ser Phe Thr Gln Tyr Ser Ser Thr 
                245                 250                 255     
His Gln Glu Val Arg Gly Gly Asp Gly Thr Lys Ala His Gly Val Phe 
            260                 265                 270         
Glu Gly Lys Ala Gly Phe Gln Ala Trp Val Asp Ser Val Gly Thr Ser 
        275                 280                 285             
Pro Asp Phe Val Asp Phe Val Pro Thr Ile Pro Met Leu Glu Ile Trp 
    290                 295                 300                 
Ser Leu Cys Ser Ser Glu Ala Gln Ala Glu Ala Met Arg Lys His Tyr 
305                 310                 315                 320 
Asp Asp Val Trp Ala Pro Ala Gln Ser Glu Lys Tyr Arg Val Lys Ala 
                325                 330                 335     
Asn Tyr Ile Asp Gln Leu Val Val Ile Thr Gly Gly Ser Ser Thr Ile 
            340                 345                 350         
Glu Pro Pro Val Gly Tyr Ser Lys Ile Glu Tyr Asp Leu Asn Ala Gly 
        355                 360                 365             
Ala Gly Gly Asp Phe Ile Tyr Leu Cys Tyr His Glu Gln Thr Trp Gln 
    370                 375                 380                 
Ala Asp Arg Pro Lys Asp Ala Val Thr Asp Ile Arg Ile Ile Phe Asn 
385                 390                 395                 400 
Lys Glu Pro Thr Pro Pro Gly Tyr Thr Lys Leu Pro Gln Asp Leu Asn 
                405                 410                 415     
Lys Gly Ala Gly Gly Asp Asp Val Phe Leu Cys Tyr Lys Thr Glu Ala 
            420                 425                 430         
Tyr Asn Thr Asp Thr Ala Ile Asn Lys Val Thr Val Ile Gly Gly Asn 
        435                 440                 445             
Asn Ala Asp Ile Asn Ala Pro Tyr Gly Tyr Leu Lys Val Pro Gly Asp 
    450                 455                 460                 
Leu Asn Arg Gly Ala Gly Gly Asn Phe Ile Tyr Ala Cys Thr Phe Val 
465                 470                 475                 480 
Gly Lys 
        

<210>  144
<211>  482
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  144
Met Glu Asn Ile Asp Leu Pro Gln Gly Leu Val Asn Phe Ser Thr Gln 
1               5                   10                  15      
His Leu Gln Leu Ile Arg Phe Lys Ala Gly Leu Asn Glu Thr Val Leu 
            20                  25                  30          
Pro Gly Val Glu Ala Ile Gly Leu Gly Tyr Asn Pro Phe Ile Ser Tyr 
        35                  40                  45              
Ala Ser Val Asn Ser Gly Ala Val Gln Leu Phe Asp Trp Ala Thr Ala 
    50                  55                  60                  
Lys Lys Arg Glu Val Pro Phe Lys Ala Gly Tyr Phe Val Pro Glu Ile 
65                  70                  75                  80  
Val Asp Val Gln Gln Asn Asp Ser Ala Ser Tyr Thr Asn Ile Ser Gly 
                85                  90                  95      
Asn Thr Val Thr Glu Tyr Gln Arg Ser Leu Ala Val Ser Val Ala Ile 
            100                 105                 110         
Glu Gly Lys Tyr Asn Phe Phe Ser Gly Ser Leu Ser Thr Asp Tyr Asp 
        115                 120                 125             
Glu Asn Ser Leu Arg Asn Ala Glu Asn Glu Phe Thr Arg Ile Gln Gln 
    130                 135                 140                 
Ser Ile Asn Leu Trp Ser Leu Arg Leu Pro Ser Val Lys Ser Leu Arg 
145                 150                 155                 160 
Asp Leu Met Leu Pro His Met Arg Glu Gln Leu Asp Glu Leu Asp Val 
                165                 170                 175     
Lys Asn Pro Ser Ala Ile Ser Arg Phe Phe Asp Arg Val Gly Ser His 
            180                 185                 190         
Phe Leu Thr Gly Ile Val Met Gly Gly Arg Ala Ile Leu Ala Ala Ser 
        195                 200                 205             
Thr Asn Lys Leu Lys Val Lys Arg Asp Tyr Ser Val Ser Val Ile Ala 
    210                 215                 220                 
Lys Ala Ser Tyr Glu Gly Leu Thr Gly Gln Leu Ser Ala Glu Ala Arg 
225                 230                 235                 240 
Thr Lys Tyr Gly Glu Ser Met Ser Ser Phe Thr Gln Tyr Ser Ser Thr 
                245                 250                 255     
His Gln Glu Val Arg Gly Gly Asp Gly Thr Lys Ala His Gly Val Phe 
            260                 265                 270         
Glu Gly Lys Ala Gly Phe Gln Ala Trp Val Asp Ser Val Gly Thr Ser 
        275                 280                 285             
Pro Asp Phe Val Asp Phe Val Pro Thr Ile Pro Met Leu Glu Ile Trp 
    290                 295                 300                 
Ser Leu Cys Ser Ser Glu Ala Gln Ala Glu Ala Met Arg Lys His Tyr 
305                 310                 315                 320 
Asp Asp Val Trp Ala Pro Ala Gln Ser Glu Lys Tyr Arg Val Lys Ala 
                325                 330                 335     
Asn Tyr Ile Asp Gln Leu Val Val Ile Thr Gly Gly Ser Ser Thr Ile 
            340                 345                 350         
Glu Pro Pro Val Gly Tyr Ser Lys Ile Glu Tyr Asp Leu Asn Ala Gly 
        355                 360                 365             
Ala Gly Gly Asp Phe Ile Tyr Leu Cys Tyr His Glu Gln Thr Trp Gln 
    370                 375                 380                 
Ala Asp Arg Pro Lys Asp Ala Val Thr Asp Ile Arg Ile Ile Phe Asn 
385                 390                 395                 400 
Lys Glu Pro Thr Pro Pro Gly Tyr Thr Lys Leu Pro Gln Asp Leu Asn 
                405                 410                 415     
Lys Gly Ala Gly Gly Asp Asp Val Phe Leu Cys Tyr Lys Thr Glu Ala 
            420                 425                 430         
Tyr Asn Thr Asp Thr Ala Ile Asn Lys Val Thr Val Ile Gly Gly Asn 
        435                 440                 445             
Asn Ala Asp Ile Asn Ala Pro Tyr Gly Tyr Leu Lys Val Pro Gly Asp 
    450                 455                 460                 
Leu Asn Arg Gly Ala Gly Gly Asn Phe Ile Tyr Ala Cys Thr Phe Val 
465                 470                 475                 480 
Gly Lys 
        

<210>  145
<211>  482
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<220>
<221>  misc_feature
<222>  (278)..(278)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (288)..(288)
<223>  Xaa can be any naturally occurring amino acid

<400>  145
Met Glu Asn Ile Asp Leu Pro Gln Gly Leu Val Asn Phe Ser Thr Gln 
1               5                   10                  15      
His Leu Gln Leu Ile Arg Phe Lys Ala Gly Leu Asn Glu Thr Val Leu 
            20                  25                  30          
Pro Gly Val Glu Ala Ile Gly Leu Gly Tyr Asn Pro Phe Ile Ser Tyr 
        35                  40                  45              
Ala Ser Val Asn Ser Gly Ala Val Gln Leu Phe Asp Trp Ala Thr Ala 
    50                  55                  60                  
Lys Lys Arg Glu Val Pro Phe Lys Ala Gly Tyr Phe Val Pro Glu Ile 
65                  70                  75                  80  
Val Asp Val Gln Gln Asn Asp Ser Ala Thr Tyr Thr Asn Val Ser Gly 
                85                  90                  95      
Asn Thr Ile Ser Glu Tyr Gln Arg Ser Leu Ala Thr Ser Val Ala Ile 
            100                 105                 110         
Glu Gly Arg Tyr Asn Phe Phe Ser Gly Ser Leu Ser Thr Asp Phe Asp 
        115                 120                 125             
Glu Asn Ser Leu Arg Asn Ala Glu Asn Glu Phe Thr Arg Ile Gln Gln 
    130                 135                 140                 
Ser Ile Asn Leu Trp Ser Leu Arg Leu Pro Ser Val Lys Ser Leu Arg 
145                 150                 155                 160 
Asp Leu Met Leu Pro His Met Arg Gln Gln Leu Asp Glu Leu Asn Val 
                165                 170                 175     
Asn Asp Pro Lys Ala Ile Ser Arg Tyr Phe Asp Arg Val Gly Ser His 
            180                 185                 190         
Phe Leu Thr Gly Ile Val Met Gly Gly Arg Ala Ile Leu Ala Ser Ser 
        195                 200                 205             
Thr Asn Lys Leu Arg Val Lys Arg Asp Tyr Ser Val Ser Val Val Ala 
    210                 215                 220                 
Lys Ala Ser Tyr Glu Gly Leu Thr Gly Gln Leu Ser Ala Glu Ala Lys 
225                 230                 235                 240 
Ala Lys Tyr Gly Glu Ser Met Ser Ser Phe Thr Gln Tyr Ser Ser Thr 
                245                 250                 255     
His Gln Glu Val Arg Gly Gly Asp Gly Thr Lys Ala His Gly Val Phe 
            260                 265                 270         
Glu Gly Lys Ala Gly Xaa Gln Ala Trp Val Asp Ser Val Gly Thr Xaa 
        275                 280                 285             
Pro Asp Phe Val Asp Phe Val Pro Thr Ile Pro Met Gln Glu Ile Trp 
    290                 295                 300                 
Ser Leu Cys Lys Thr Asp Ser Gln Ala Glu Ala Met Lys Arg His Phe 
305                 310                 315                 320 
Asp Thr Val Trp Ala Arg Glu Gln Ser Asp Lys Tyr Arg Ile Lys Ala 
                325                 330                 335     
Asn Tyr Ile Asp Gln Leu Val Val Ile Thr Gly Asp Ser Ser Thr Ile 
            340                 345                 350         
Glu Pro Pro Val Gly Tyr Ser Lys Ile Glu Tyr Asp Leu Asn Ala Gly 
        355                 360                 365             
Ala Gly Gly Asp Phe Ile Tyr Leu Cys Tyr His Glu Gln Thr Trp Gln 
    370                 375                 380                 
Ala Asp Arg Pro Lys Asp Ala Val Thr Asp Ile Arg Ile Ile Phe Asn 
385                 390                 395                 400 
Lys Glu Pro Thr Pro Pro Gly Tyr Thr Lys Leu Pro Gln Asp Leu Asn 
                405                 410                 415     
Lys Gly Ala Gly Gly Ala Asp Ile Tyr Leu Cys Phe Lys Leu Glu Gly 
            420                 425                 430         
Tyr Asn Thr Asp Thr Ala Ile Asn Lys Ile Thr Val Ile Ser Gly Asn 
        435                 440                 445             
Asn Pro Asp Ile Asn Ala Pro Tyr Gly Tyr Glu Lys Val Pro Gly Asp 
    450                 455                 460                 
Leu Asn Lys Gly Asp Lys Gly Asn Phe Ile Tyr Ala Cys Thr Phe Val 
465                 470                 475                 480 
Gly Lys 
        

<210>  146
<211>  483
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  146
Met Glu Asn Ile Asp Leu Pro Gln Gly Leu Val Asn Phe Ser Thr Gln 
1               5                   10                  15      
His Leu Gln Leu Ile Arg Phe Lys Ala Gly Leu Asn Glu Thr Val Leu 
            20                  25                  30          
Pro Gly Val Glu Ala Ile Gly Leu Gly Tyr Asn Pro Phe Ile Ser Tyr 
        35                  40                  45              
Ala Ser Val Asn Ser Gly Ala Val Gln Leu Phe Asp Trp Ala Thr Ala 
    50                  55                  60                  
Lys Lys Arg Glu Val Pro Phe Lys Ala Gly Tyr Phe Val Pro Glu Ile 
65                  70                  75                  80  
Val Asp Val Gln Gln Asn Asp Ser Ala Thr Tyr Thr Asn Val Ser Gly 
                85                  90                  95      
Asn Thr Ile Ser Glu Tyr Gln Arg Ser Leu Ala Thr Ser Val Ala Ile 
            100                 105                 110         
Glu Gly Arg Tyr Asn Phe Phe Ser Gly Ser Leu Ser Thr Asp Phe Asp 
        115                 120                 125             
Ser Asn Ser Leu Arg Asn Ala Glu Asn Glu Phe Thr Arg Ile Gln Gln 
    130                 135                 140                 
Ser Ile Asn Leu Trp Ser Leu Arg Leu Pro Ser Val Lys Ser Leu Arg 
145                 150                 155                 160 
Asp Leu Met Leu Pro His Met Arg Glu Gln Leu Asp Glu Leu Asp Val 
                165                 170                 175     
Lys Asn Pro Ser Ala Ile Ser Arg Phe Phe Asp Arg Val Gly Ser His 
            180                 185                 190         
Phe Leu Thr Gly Ile Val Met Gly Gly Arg Ala Ile Leu Ala Ala Ser 
        195                 200                 205             
Thr Asn Lys Leu Lys Val Lys Arg Asp Tyr Ser Val Ser Val Val Ala 
    210                 215                 220                 
Lys Ala Ser Tyr Glu Gly Leu Thr Gly Gln Leu Ser Ala Glu Thr Arg 
225                 230                 235                 240 
Thr Lys Tyr Gly Glu Ser Met Ser Ser Phe Thr Gln Tyr Ser Asn Thr 
                245                 250                 255     
His Gln Glu Val Arg Gly Gly Asp Gly Ala Lys Ala His Gly Val Phe 
            260                 265                 270         
Ser Gly Lys Lys Glu Asp Phe Gln Ala Trp Val Asp Ser Val Ser Ala 
        275                 280                 285             
Ser Pro Asp Phe Val Asp Phe Val Pro Thr Ile Pro Met Leu Glu Ile 
    290                 295                 300                 
Trp Ser Leu Cys Lys Thr Asp Ser Gln Ala Glu Ala Met Lys Arg His 
305                 310                 315                 320 
Phe Asp Thr Val Trp Ala Arg Glu Gln Ser Asp Lys Tyr Arg Ile Lys 
                325                 330                 335     
Ala Asn Tyr Ile Asp Gln Leu Val Val Ile Thr Gly Gly Ser Ser Thr 
            340                 345                 350         
Ile Glu Pro Pro Val Gly Tyr Ser Lys Ile Glu Tyr Asp Leu Asn Ala 
        355                 360                 365             
Gly Ala Gly Gly Asp Phe Ile Tyr Leu Cys Tyr His Glu Gln Thr Trp 
    370                 375                 380                 
Gln Ala Asp Arg Pro Lys Asp Ala Val Thr Asp Ile Arg Ile Ile Phe 
385                 390                 395                 400 
Asn Lys Glu Pro Thr Pro Pro Gly Tyr Thr Lys Leu Pro Gln Asp Leu 
                405                 410                 415     
Asn Lys Gly Ala Gly Gly Asp Asp Ile Tyr Leu Cys Tyr Lys Leu Glu 
            420                 425                 430         
Gly Tyr Asn Thr Asp Thr Ala Ile Asn Lys Val Thr Val Ile Gly Gly 
        435                 440                 445             
Asn Asn Ala Asp Ile Asn Ala Pro Tyr Gly Tyr Leu Lys Val Pro Gly 
    450                 455                 460                 
Asp Leu Asn Arg Gly Ala Gly Gly Asn Phe Ile Tyr Ala Cys Thr Phe 
465                 470                 475                 480 
Val Gly Lys 
            

<210>  147
<211>  483
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  147
Met Glu Asn Ile Asp Leu Pro Gln Gly Leu Val Asn Phe Ser Lys Gln 
1               5                   10                  15      
His Leu Gln Leu Ile Arg Phe Lys Ala Gly Leu Asn Glu Thr Val Leu 
            20                  25                  30          
Pro Gly Val Glu Ala Ile Gly Leu Gly Tyr Asn Pro Phe Ile Ser Tyr 
        35                  40                  45              
Ala Ser Val Asn Ser Gly Ala Val Gln Leu Phe Asp Trp Ala Thr Ala 
    50                  55                  60                  
Lys Lys Arg Glu Val Pro Phe Lys Ala Gly Tyr Phe Val Pro Glu Ile 
65                  70                  75                  80  
Val Asp Val Gln Gln Asn Asp Ser Ala Ser Tyr Thr Asn Ile Ser Gly 
                85                  90                  95      
Asn Thr Val Thr Glu Tyr Gln Arg Ser Leu Ala Thr Ser Val Ala Ile 
            100                 105                 110         
Glu Gly Arg Tyr Asn Phe Phe Ser Gly Ser Leu Ser Thr Asp Tyr Asp 
        115                 120                 125             
Glu Asn Ser Leu Arg Asn Ala Glu Asn Glu Phe Thr Arg Ile Gln Gln 
    130                 135                 140                 
Ser Ile Asn Leu Trp Ser Leu Arg Leu Pro Ser Val Lys Ser Leu Arg 
145                 150                 155                 160 
Asp Leu Met Leu Pro His Met Arg Glu Gln Leu Asp Glu Leu Asp Val 
                165                 170                 175     
Lys Asn Pro Ser Ala Ile Ser Arg Phe Phe Asp Arg Val Gly Ser His 
            180                 185                 190         
Phe Leu Thr Gly Ile Val Met Gly Gly Arg Ala Ile Leu Ala Ala Ser 
        195                 200                 205             
Thr Asn Lys Leu Lys Val Lys Arg Asp Tyr Ser Val Ser Val Val Ala 
    210                 215                 220                 
Lys Ala Ser Tyr Glu Gly Leu Thr Gly Gln Leu Ser Ala Glu Ala Lys 
225                 230                 235                 240 
Ala Lys Tyr Gly Glu Ser Ile Ser Ser Phe Thr Gln Tyr Ser Ser Thr 
                245                 250                 255     
His Gln Glu Val Arg Gly Gly Asp Gly Thr Lys Ala His Gly Val Phe 
            260                 265                 270         
Ser Gly Lys Lys Glu Asp Phe Gln Ala Trp Val Asp Ser Val Ser Ala 
        275                 280                 285             
Ser Pro Asp Phe Val Asp Phe Val Pro Thr Ile Pro Met Gln Glu Ile 
    290                 295                 300                 
Trp Thr Leu Cys Ser Ser Glu Ala Gln Ala Glu Ala Met Arg Lys His 
305                 310                 315                 320 
Tyr Asp Asp Val Trp Ala Pro Ala Gln Ser Glu Lys Tyr Arg Val Lys 
                325                 330                 335     
Ala Asn Tyr Ile Asp Gln Leu Val Val Ile Thr Gly Asp Ser Ser Thr 
            340                 345                 350         
Ile Glu Pro Pro Ala Gly Tyr Thr Lys Ile Pro Tyr Asp Leu Asn Ala 
        355                 360                 365             
Gly Ala Gly Gly Asp Phe Ile Tyr Leu Cys Tyr His Glu Gln Thr Trp 
    370                 375                 380                 
Gln Ala Asp Arg Pro Lys Asp Ala Val Thr Asp Ile Arg Ile Ile Phe 
385                 390                 395                 400 
Asn Lys Glu Pro Thr Pro Pro Gly Tyr Thr Lys Leu Pro Gln Asp Leu 
                405                 410                 415     
Asn Lys Gly Ala Gly Gly Asp Asp Val Phe Leu Cys Tyr Lys Thr Glu 
            420                 425                 430         
Ala Tyr Asn Thr Asp Thr Ala Ile Asn Lys Val Thr Val Ile Gly Gly 
        435                 440                 445             
Asn Asn Ala Asp Ile Asn Ala Pro Tyr Gly Tyr Leu Lys Val Pro Gly 
    450                 455                 460                 
Asp Leu Asn Arg Gly Ala Gly Gly Asn Phe Ile Tyr Ala Cys Thr Phe 
465                 470                 475                 480 
Val Gly Lys 
            

<210>  148
<211>  483
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  148
Met Glu Asn Ile Asp Leu Pro Gln Gly Leu Val Asn Phe Ser Thr Gln 
1               5                   10                  15      
His Leu Gln Leu Ile Arg Phe Lys Ala Gly Leu Asn Glu Thr Val Leu 
            20                  25                  30          
Pro Gly Val Glu Ala Ile Gly Leu Gly Tyr Asn Pro Phe Ile Ser Tyr 
        35                  40                  45              
Ala Ser Val Asn Ser Gly Ala Val Gln Leu Phe Asp Trp Ala Thr Ala 
    50                  55                  60                  
Lys Lys Arg Glu Val Pro Phe Lys Ala Gly Tyr Phe Val Pro Glu Ile 
65                  70                  75                  80  
Val Asp Val Gln Gln Asn Asp Ser Ala Thr Tyr Thr Asn Ile Ser Gly 
                85                  90                  95      
Asn Thr Ile Ser Glu Tyr Gln Arg Ser Leu Ala Thr Ser Val Ala Ile 
            100                 105                 110         
Glu Gly Arg Tyr Asn Phe Phe Ser Gly Ser Leu Ser Thr Asp Tyr Asp 
        115                 120                 125             
Glu Asn Ser Leu Arg Asn Ala Glu Asn Glu Phe Thr Arg Ile Gln Gln 
    130                 135                 140                 
Ser Ile Asn Leu Trp Ser Leu Arg Leu Pro Ser Val Lys Ser Leu Arg 
145                 150                 155                 160 
Asp Leu Met Leu Pro His Met Arg Glu Gln Leu Asp Glu Leu Asp Val 
                165                 170                 175     
Lys Asn Pro Lys Ala Ile Ser Arg Tyr Phe Asp Arg Val Gly Ser His 
            180                 185                 190         
Phe Leu Thr Gly Ile Val Met Gly Gly Arg Ala Ile Leu Ala Ala Ser 
        195                 200                 205             
Thr Asn Lys Leu Lys Val Lys Arg Asp Tyr Ser Val Ser Val Ile Ala 
    210                 215                 220                 
Lys Ala Ser Tyr Glu Gly Leu Thr Gly Gln Leu Ser Ala Glu Ala Lys 
225                 230                 235                 240 
Ala Lys Tyr Gly Glu Ser Ile Ser Ser Phe Thr Gln Tyr Ser Asn Thr 
                245                 250                 255     
His Gln Glu Val Arg Gly Gly Asp Gly Ala Lys Ala His Gly Val Phe 
            260                 265                 270         
Ser Gly Lys Lys Glu Asp Phe Gln Ala Trp Val Asp Ser Val Ser Ala 
        275                 280                 285             
Ser Pro Asp Phe Val Asp Phe Val Pro Thr Ile Pro Met Gln Glu Ile 
    290                 295                 300                 
Trp Thr Leu Cys Ser Ser Glu Ala Gln Ala Glu Ala Met Arg Lys His 
305                 310                 315                 320 
Tyr Asp Asp Val Trp Ala Pro Ala Gln Ser Glu Lys Tyr Arg Val Lys 
                325                 330                 335     
Ala Asn Tyr Ile Asp Gln Leu Val Val Ile Thr Gly Asp Ser Ser Thr 
            340                 345                 350         
Ile Glu Pro Pro Ala Gly Tyr Ser Lys Ile Glu Tyr Asp Leu Asn Ala 
        355                 360                 365             
Gly Ala Gly Gly Asp Phe Ile Tyr Leu Cys Tyr His Glu Gln Thr Trp 
    370                 375                 380                 
Gln Ala Asp Arg Pro Lys Asp Ala Val Thr Asp Ile Arg Ile Ile Phe 
385                 390                 395                 400 
Asn Lys Glu Pro Thr Pro Pro Gly Tyr Thr Lys Leu Pro Gln Asp Leu 
                405                 410                 415     
Asn Lys Gly Ala Gly Gly Asp Asp Val Phe Leu Cys Tyr Lys Thr Glu 
            420                 425                 430         
Ala Tyr Asn Thr Asp Thr Ala Ile Asn Lys Ile Thr Val Ile Ser Gly 
        435                 440                 445             
Asn Asn Pro Asp Ile Asn Ala Pro Tyr Gly Tyr Leu Lys Val Pro Gly 
    450                 455                 460                 
Asp Leu Asn Lys Gly Ala Lys Gly Asn Phe Ile Tyr Ala Cys Thr Phe 
465                 470                 475                 480 
Val Gly Lys 
            

<210>  149
<211>  483
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  149
Met Glu Asn Ile Asp Leu Pro Gln Gly Leu Val Asn Phe Ser Thr Gln 
1               5                   10                  15      
His Leu Gln Leu Ile Arg Phe Lys Ala Gly Leu Asn Glu Thr Val Leu 
            20                  25                  30          
Pro Gly Val Glu Ala Ile Gly Leu Gly Tyr Asn Pro Phe Ile Ser Tyr 
        35                  40                  45              
Ala Ser Val Asn Ser Gly Ala Val Gln Leu Phe Asp Trp Ala Thr Ala 
    50                  55                  60                  
Lys Lys Arg Glu Val Pro Phe Lys Ala Gly Tyr Phe Val Pro Glu Ile 
65                  70                  75                  80  
Val Asp Val Gln Gln Asn Asp Ser Ala Thr Tyr Thr Asn Val Ser Gly 
                85                  90                  95      
Asn Thr Ile Ser Glu Tyr Gln Arg Ser Leu Ala Thr Ser Val Ala Ile 
            100                 105                 110         
Glu Gly Arg Tyr Asn Phe Phe Ser Gly Ser Leu Ser Thr Asp Phe Asp 
        115                 120                 125             
Ser Asn Ser Leu Arg Asn Ala Glu Asn Glu Phe Thr Arg Ile Gln Gln 
    130                 135                 140                 
Ser Ile Asn Leu Trp Ser Leu Arg Leu Pro Ser Val Lys Ser Leu Arg 
145                 150                 155                 160 
Glu Leu Met Leu Pro His Met Arg Gln Gln Leu Asp Glu Leu Asn Val 
                165                 170                 175     
Asn Asp Pro Lys Ala Ile Ser Arg Tyr Phe Asp Arg Val Gly Ser His 
            180                 185                 190         
Phe Leu Thr Gly Ile Val Met Gly Gly Arg Ala Ile Leu Ala Ser Ser 
        195                 200                 205             
Thr Asn Lys Leu Arg Val Lys Arg Asp Tyr Ser Val Ser Val Val Ala 
    210                 215                 220                 
Lys Ala Ser Tyr Glu Gly Leu Thr Gly Gln Leu Ser Ala Glu Ala Lys 
225                 230                 235                 240 
Ala Lys Tyr Gly Glu Ser Ile Ser Ser Phe Thr Gln Tyr Ser Asn Thr 
                245                 250                 255     
His Gln Glu Val Arg Gly Gly Asp Gly Ala Lys Ala His Gly Val Phe 
            260                 265                 270         
Ser Gly Lys Lys Glu Asp Phe Gln Ala Trp Val Asp Ser Val Ser Ala 
        275                 280                 285             
Ser Pro Asp Phe Val Asp Phe Val Pro Thr Ile Pro Met Gln Glu Ile 
    290                 295                 300                 
Trp Thr Leu Cys Ser Ser Glu Ala Gln Ala Glu Ala Met Lys Arg His 
305                 310                 315                 320 
Phe Asp Thr Val Trp Ala Arg Glu Gln Ser Asp Lys Tyr Arg Ile Lys 
                325                 330                 335     
Ala Asn Tyr Ile Asp Gln Leu Val Val Ile Thr Gly Asp Ser Ser Thr 
            340                 345                 350         
Ile Glu Pro Pro Ala Gly Tyr Thr Lys Ile Pro Tyr Asp Leu Asn Ala 
        355                 360                 365             
Gly Ala Lys Gly Asp Phe Ile Tyr Leu Cys Tyr His Glu Gln Ala Trp 
    370                 375                 380                 
Tyr Pro Asp Asn Thr Lys Pro Ala Val Thr Ala Ile Lys Ile Ile Tyr 
385                 390                 395                 400 
Asp Arg Glu Pro Val Pro Pro Gly Tyr Thr Lys Leu Pro Gln Asp Leu 
                405                 410                 415     
Asn Lys Gly Ala Gly Gly Asp Asp Val Phe Leu Cys Tyr Lys Thr Glu 
            420                 425                 430         
Ala Tyr Asn Thr Asp Thr Ala Ile Asn Lys Val Thr Val Ile Gly Gly 
        435                 440                 445             
Asn Asn Ala Asp Ile Asn Ala Pro Tyr Gly Tyr Leu Lys Val Pro Gly 
    450                 455                 460                 
Asp Leu Asn Arg Gly Ala Gly Gly Asn Phe Ile Tyr Ala Cys Thr Phe 
465                 470                 475                 480 
Val Gly Lys 
            

<210>  150
<211>  484
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  150
Met Glu His Val Asp Leu Pro Thr Gly Leu Val Lys Phe Ser Ser Asn 
1               5                   10                  15      
His His Leu Gln Leu Leu Arg Asp Thr Ala Asp Leu Ser Glu Ser Val 
            20                  25                  30          
Leu Pro Gly Val Glu Ala Ile Gly Leu Gly Tyr Asn Pro Phe Leu Gly 
        35                  40                  45              
Tyr Ala Gly Val Gly Ser Gly Thr Val Gln Leu Phe Asp Trp Ala Thr 
    50                  55                  60                  
Ala Lys Lys Arg Glu Val Pro Phe Lys Ala Gly Tyr Phe Val Pro Glu 
65                  70                  75                  80  
Ile Val Asp Val Gln Gln Asn Asp Ser Ala Ser Tyr Thr Asn Ile Ser 
                85                  90                  95      
Gly Asn Thr Val Thr Glu Tyr Gln Arg Ser Leu Ala Thr Ser Val Ala 
            100                 105                 110         
Ile Glu Gly Arg Tyr Asn Phe Phe Ser Gly Ser Leu Ser Thr Asp Phe 
        115                 120                 125             
Asp Ser Asn Ser Leu Arg Asn Ala Glu Asn Glu Phe Thr Arg Ile Gln 
    130                 135                 140                 
Gln Ser Ile Asn Leu Trp Ser Leu Arg Leu Pro Ser Val Lys Ser Leu 
145                 150                 155                 160 
Arg Glu Leu Met Leu Pro His Met Arg Gln Gln Leu Asp Glu Leu Asn 
                165                 170                 175     
Val Asn Asp Pro Lys Ala Ile Ser Arg Tyr Phe Asp Arg Val Gly Ser 
            180                 185                 190         
His Phe Leu Thr Gly Ile Val Met Gly Gly Arg Ala Ile Leu Ala Ser 
        195                 200                 205             
Ser Thr Asn Lys Leu Arg Val Lys Arg Asp Tyr Ser Val Ser Val Ile 
    210                 215                 220                 
Ala Lys Ala Ser Tyr Glu Gly Leu Thr Gly Gln Leu Ser Ala Glu Ala 
225                 230                 235                 240 
Arg Thr Lys Tyr Gly Glu Ser Met Ser Ser Phe Thr Gln Tyr Ser Asn 
                245                 250                 255     
Thr His Gln Glu Val Arg Gly Gly Asp Gly Thr Lys Ala His Gly Val 
            260                 265                 270         
Phe Ser Gly Lys Lys Glu Asp Phe Gln Ala Trp Val Asp Ser Val Ser 
        275                 280                 285             
Ala Ser Pro Asp Phe Val Asp Phe Val Pro Thr Ile Pro Met Leu Glu 
    290                 295                 300                 
Ile Trp Ser Leu Cys Ser Ser Glu Ala Gln Ala Glu Ala Met Arg Lys 
305                 310                 315                 320 
His Tyr Asp Asp Val Trp Ala Pro Ala Gln Ser Glu Lys Tyr Arg Val 
                325                 330                 335     
Lys Ala Asn Tyr Ile Asp Gln Leu Val Val Ile Thr Gly Asp Ser Ser 
            340                 345                 350         
Thr Ile Glu Pro Pro Ala Gly Tyr Thr Lys Ile Pro Tyr Asp Leu Asn 
        355                 360                 365             
Ala Gly Ala Lys Gly Asp Phe Ile Tyr Leu Cys Tyr His Glu Gln Ala 
    370                 375                 380                 
Trp Tyr Pro Asp Asn Thr Lys Pro Ala Val Met Ala Ile Lys Ile Ile 
385                 390                 395                 400 
Tyr Asp Arg Glu Pro Val Pro Thr Gly Tyr Ile Lys Leu Pro Gln Asp 
                405                 410                 415     
Leu Asn Lys Gly Ala Gly Gly Asp Asp Val Phe Leu Cys Tyr Lys Thr 
            420                 425                 430         
Glu Ala Tyr Asn Thr Asp Thr Ala Ile Asn Lys Val Thr Val Ile Gly 
        435                 440                 445             
Gly Asn Asn Ala Asp Ile Asn Ala Pro Tyr Gly Tyr Leu Lys Val Pro 
    450                 455                 460                 
Gly Asp Leu Asn Arg Gly Ala Gly Gly Asn Phe Ile Tyr Ala Cys Thr 
465                 470                 475                 480 
Phe Val Gly Lys 
                

<210>  151
<211>  482
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  151
Met Glu Asn Ile Asp Leu Pro Gln Gly Leu Val Asn Phe Ser Thr Gln 
1               5                   10                  15      
His Leu Gln Leu Ile Arg Phe Lys Ala Gly Leu Asn Glu Thr Val Leu 
            20                  25                  30          
Pro Gly Val Glu Ala Ile Gly Leu Gly Tyr Asn Pro Phe Ile Ser Tyr 
        35                  40                  45              
Ala Ser Val Asn Ser Gly Ala Val Gln Leu Phe Asp Trp Ala Thr Ala 
    50                  55                  60                  
Lys Lys Arg Glu Val Pro Phe Lys Ala Gly Tyr Phe Val Pro Glu Ile 
65                  70                  75                  80  
Val Asp Val Gln Gln Asn Asp Ser Ala Ser Tyr Thr Asn Ile Ser Gly 
                85                  90                  95      
Asn Thr Ile Ser Glu Tyr Gln Arg Ser Leu Ala Val Ser Val Ala Ile 
            100                 105                 110         
Glu Gly Lys Tyr Asn Phe Phe Ser Gly Ser Leu Ser Thr Asp Tyr Asp 
        115                 120                 125             
Glu Asn Ser Leu Arg Asn Ala Glu Asn Glu Phe Thr Arg Ile Gln Gln 
    130                 135                 140                 
Ser Ile Asn Leu Trp Ser Leu Arg Leu Pro Ser Val Lys Ser Leu Arg 
145                 150                 155                 160 
Asp Leu Met Leu Pro His Met Arg Glu Gln Leu Asp Glu Leu Asp Val 
                165                 170                 175     
Lys Asn Pro Ser Ala Ile Ser Arg Phe Phe Asp Arg Val Gly Ser His 
            180                 185                 190         
Phe Leu Thr Gly Ile Val Met Gly Gly Arg Ala Ile Leu Ala Ala Ser 
        195                 200                 205             
Thr Asn Lys Leu Lys Val Lys Arg Asp Tyr Ser Val Ser Val Ile Ala 
    210                 215                 220                 
Lys Ala Ser Tyr Glu Gly Leu Thr Gly Gln Leu Ser Ala Glu Ala Arg 
225                 230                 235                 240 
Thr Lys Tyr Gly Glu Ser Met Ser Ser Phe Thr Gln Tyr Ser Ser Thr 
                245                 250                 255     
His Gln Glu Val Arg Gly Gly Asp Gly Thr Lys Ala His Gly Val Phe 
            260                 265                 270         
Glu Gly Lys Ala Gly Phe Gln Ala Trp Val Asp Ser Val Gly Thr Ser 
        275                 280                 285             
Pro Asp Phe Val Asp Phe Val Pro Thr Ile Pro Met Gln Glu Ile Trp 
    290                 295                 300                 
Thr Leu Cys Ser Ser Glu Ala Gln Ala Glu Ala Met Arg Lys His Tyr 
305                 310                 315                 320 
Asp Asp Val Trp Ala Pro Ala Gln Ser Glu Lys Tyr Arg Val Lys Ala 
                325                 330                 335     
Asn Tyr Ile Asp Gln Leu Val Val Ile Thr Gly Gly Ser Ser Thr Ile 
            340                 345                 350         
Glu Pro Pro Val Gly Tyr Ser Lys Ile Glu Tyr Asp Leu Asn Ala Gly 
        355                 360                 365             
Ala Gly Gly Asp Phe Ile Tyr Leu Cys Tyr His Glu Gln Ala Trp Tyr 
    370                 375                 380                 
Pro Asp Asn Thr Lys Pro Ala Val Thr Ala Ile Lys Ile Ile Tyr Asp 
385                 390                 395                 400 
Arg Glu Pro Val Pro Thr Gly Tyr Ile Lys Leu Pro Gln Asp Leu Asn 
                405                 410                 415     
Lys Gly Ala Gly Gly Ala Asp Ile Tyr Leu Cys Tyr Lys Leu Glu Gly 
            420                 425                 430         
Tyr Asn Thr Asp Thr Ala Ile Asn Lys Ile Thr Val Ile Ser Gly Asn 
        435                 440                 445             
Asn Pro Asp Ile Asn Ala Pro Tyr Gly Tyr Glu Lys Val Pro Gly Asp 
    450                 455                 460                 
Leu Asn Lys Gly Ala Lys Gly Asn Phe Ile Tyr Ala Cys Thr Phe Val 
465                 470                 475                 480 
Gly Lys 
        

<210>  152
<211>  483
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  152
Met Glu His Val Asp Leu Pro Thr Gly Leu Val Lys Phe Ser Ser Asn 
1               5                   10                  15      
His His Leu Gln Leu Leu Arg Asp Thr Ala Asp Leu Ser Glu Ser Val 
            20                  25                  30          
Leu Pro Gly Val Glu Ala Ile Gly Leu Gly Tyr Asn Pro Phe Leu Gly 
        35                  40                  45              
Tyr Ala Gly Val Gly Ser Gly Thr Val Gln Leu Phe Asp Trp Asn Asn 
    50                  55                  60                  
Ala Lys Lys Lys Lys Val Ser Phe Lys Pro Glu Phe Val Val Pro Glu 
65                  70                  75                  80  
Ile Val Asp Val Gln Gln Asn Asp Ser Ala Ser Tyr Thr Asn Val Ser 
                85                  90                  95      
Gly Asn Thr Val Thr Glu Tyr Gln Arg Ser Leu Ala Val Ser Val Ala 
            100                 105                 110         
Ile Glu Gly Lys Tyr Asn Phe Phe Ser Gly Ser Leu Ser Thr Asp Tyr 
        115                 120                 125             
Asp Glu Asn Ser Leu Arg Asn Ala Glu Asn Glu Phe Thr Arg Ile Gln 
    130                 135                 140                 
Gln Ser Ile Asn Leu Trp Ser Leu Arg Leu Pro Ser Val Lys Ser Leu 
145                 150                 155                 160 
Arg Asp Leu Met Leu Pro His Met Arg Glu Gln Leu Asp Glu Leu Asp 
                165                 170                 175     
Val Lys Asn Pro Ser Ala Ile Ser Arg Phe Phe Asp Arg Val Gly Ser 
            180                 185                 190         
His Phe Leu Thr Gly Ile Val Met Gly Gly Arg Ala Ile Leu Ala Ala 
        195                 200                 205             
Ser Thr Asn Lys Leu Lys Val Lys Arg Asp Tyr Ser Val Ser Val Ile 
    210                 215                 220                 
Ala Lys Ala Ser Tyr Glu Gly Leu Thr Gly Gln Leu Ser Ala Glu Ala 
225                 230                 235                 240 
Arg Thr Lys Tyr Gly Glu Ser Met Ser Ser Phe Thr Gln Tyr Ser Ser 
                245                 250                 255     
Thr His Gln Glu Val Arg Gly Gly Asp Gly Thr Lys Ala His Gly Val 
            260                 265                 270         
Phe Glu Gly Lys Ala Gly Phe Gln Ala Trp Val Asp Ser Val Ser Ala 
        275                 280                 285             
Ser Pro Asp Phe Val Asp Phe Val Pro Thr Ile Pro Met Leu Glu Ile 
    290                 295                 300                 
Trp Ser Leu Cys Lys Thr Asp Ser Gln Ala Glu Ala Met Lys Arg His 
305                 310                 315                 320 
Phe Asp Thr Val Trp Ala Arg Glu Gln Ser Asp Lys Tyr Arg Ile Lys 
                325                 330                 335     
Ala Asn Tyr Ile Asp Gln Leu Val Val Ile Thr Gly Asp Ser Ser Thr 
            340                 345                 350         
Ile Glu Pro Pro Val Gly Tyr Ser Lys Ile Glu Tyr Asp Leu Asn Ala 
        355                 360                 365             
Gly Ala Gly Gly Asp Phe Ile Tyr Leu Cys Tyr His Glu Gln Thr Trp 
    370                 375                 380                 
Gln Ala Asp Arg Pro Lys Asp Ala Val Thr Asp Ile Arg Ile Ile Phe 
385                 390                 395                 400 
Asn Lys Glu Pro Thr Pro Pro Gly Tyr Thr Lys Leu Pro Gln Asp Leu 
                405                 410                 415     
Asn Lys Gly Ala Gly Gly Asp Asp Val Phe Leu Cys Tyr Lys Thr Glu 
            420                 425                 430         
Ala Tyr Asn Thr Asp Thr Ala Ile Asn Lys Val Thr Val Ile Gly Gly 
        435                 440                 445             
Asn Asn Ala Asp Ile Asn Ala Pro Tyr Gly Tyr Leu Lys Val Pro Gly 
    450                 455                 460                 
Asp Leu Asn Arg Gly Ala Gly Gly Asn Phe Ile Tyr Ala Cys Thr Phe 
465                 470                 475                 480 
Val Gly Lys 
            

<210>  153
<211>  483
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  153
Met Glu Asn Ile Asp Leu Pro Gln Gly Leu Val Asn Phe Ser Thr Gln 
1               5                   10                  15      
His Leu Gln Leu Ile Arg Phe Lys Ala Gly Leu Asn Glu Thr Val Leu 
            20                  25                  30          
Pro Gly Val Glu Ala Ile Gly Leu Gly Tyr Asn Pro Phe Ile Ser Tyr 
        35                  40                  45              
Ala Ser Val Asn Ser Gly Ala Val Gln Leu Phe Asp Trp Ala Thr Ala 
    50                  55                  60                  
Lys Lys Arg Glu Val Pro Phe Lys Ala Gly Tyr Phe Val Pro Glu Ile 
65                  70                  75                  80  
Val Asp Val Gln Gln Asn Asp Ser Ala Ser Tyr Thr Asn Val Ser Gly 
                85                  90                  95      
Asn Thr Ile Ser Glu Tyr Gln Arg Ser Leu Ala Thr Ser Val Ala Ile 
            100                 105                 110         
Glu Gly Arg Tyr Asn Phe Phe Ser Gly Ser Leu Ser Thr Asp Phe Asp 
        115                 120                 125             
Ser Asn Ser Leu Arg Asn Ala Glu Asn Glu Phe Thr Arg Ile Gln Gln 
    130                 135                 140                 
Ser Ile Asn Leu Trp Ser Leu Arg Leu Pro Ser Val Lys Ser Leu Arg 
145                 150                 155                 160 
Glu Leu Met Leu Pro His Met Arg Gln Gln Leu Asp Glu Leu Asn Val 
                165                 170                 175     
Asn Asp Pro Lys Ala Ile Ser Arg Tyr Phe Asp Arg Val Gly Ser His 
            180                 185                 190         
Phe Leu Thr Gly Ile Val Met Gly Gly Arg Ala Ile Leu Ala Ser Ser 
        195                 200                 205             
Thr Asn Lys Leu Arg Val Lys Arg Asp Tyr Ser Val Ser Val Val Ala 
    210                 215                 220                 
Lys Ala Ser Tyr Glu Gly Leu Thr Gly Gln Leu Ser Ala Glu Ala Lys 
225                 230                 235                 240 
Ala Lys Tyr Gly Glu Ser Ile Ser Ser Phe Thr Gln Tyr Ser Asn Thr 
                245                 250                 255     
His Gln Glu Val Arg Gly Gly Asp Gly Ala Lys Ala His Gly Val Phe 
            260                 265                 270         
Ser Gly Lys Lys Glu Asp Phe Gln Ala Trp Val Asp Ser Val Gly Thr 
        275                 280                 285             
Ser Pro Asp Phe Val Asp Phe Val Pro Thr Ile Pro Met Gln Glu Ile 
    290                 295                 300                 
Trp Thr Leu Cys Ser Ser Glu Ala Gln Ala Glu Ala Met Arg Lys His 
305                 310                 315                 320 
Tyr Asp Asp Val Trp Ala Pro Ala Gln Ser Glu Lys Tyr Arg Val Lys 
                325                 330                 335     
Ala Asn Tyr Ile Asp Gln Leu Val Val Ile Thr Gly Gly Ser Ser Thr 
            340                 345                 350         
Ile Glu Pro Pro Ala Gly Tyr Thr Lys Ile Pro Tyr Asp Leu Asn Ala 
        355                 360                 365             
Gly Ala Lys Gly Asp Phe Ile Tyr Leu Cys Tyr His Glu Gln Ala Trp 
    370                 375                 380                 
Tyr Pro Asp Asn Thr Lys Pro Ala Val Thr Asp Ile Arg Ile Ile Phe 
385                 390                 395                 400 
Asn Lys Glu Pro Thr Pro Pro Gly Tyr Thr Lys Leu Pro Gln Asp Leu 
                405                 410                 415     
Asn Lys Gly Ala Gly Gly Asp Asp Val Phe Leu Cys Tyr Lys Thr Glu 
            420                 425                 430         
Ala Tyr Asn Thr Asp Thr Ala Ile Asn Lys Val Thr Val Ile Gly Gly 
        435                 440                 445             
Asn Asn Ala Asp Ile Asn Ala Pro Tyr Gly Tyr Leu Lys Val Pro Gly 
    450                 455                 460                 
Asp Leu Asn Arg Gly Ala Gly Gly Asn Phe Ile Tyr Ala Cys Thr Phe 
465                 470                 475                 480 
Val Gly Lys 
            

<210>  154
<211>  483
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  154
Met Glu His Val Asp Leu Pro Thr Gly Leu Val Lys Phe Ser Ser Asn 
1               5                   10                  15      
His His Leu Gln Leu Leu Arg Asp Thr Ala Asp Leu Ser Glu Ser Val 
            20                  25                  30          
Leu Pro Gly Val Glu Ala Ile Gly Leu Gly Tyr Asn Pro Phe Leu Gly 
        35                  40                  45              
Tyr Ala Gly Val Gly Ser Gly Thr Val Gln Leu Phe Asp Trp Asn Asn 
    50                  55                  60                  
Ala Lys Lys Lys Lys Val Ser Phe Lys Pro Glu Phe Val Val Pro Glu 
65                  70                  75                  80  
Ile Val Asp Val Gln Gln Asn Asp Ser Ala Ser Tyr Thr Asn Ile Ser 
                85                  90                  95      
Gly Asn Thr Val Thr Glu Tyr Gln Arg Ser Leu Ala Thr Ser Val Ala 
            100                 105                 110         
Ile Glu Gly Arg Tyr Asn Phe Phe Ser Gly Ser Leu Ser Thr Asp Tyr 
        115                 120                 125             
Asp Glu Asn Ser Leu Arg Asn Ala Glu Asn Glu Phe Thr Arg Ile Gln 
    130                 135                 140                 
Gln Ser Ile Asn Leu Trp Ser Leu Arg Leu Pro Ser Val Lys Ser Leu 
145                 150                 155                 160 
Arg Asp Leu Met Leu Pro His Met Arg Glu Gln Leu Asp Glu Leu Asp 
                165                 170                 175     
Val Lys Asn Pro Ser Ala Ile Ser Arg Phe Phe Asp Arg Val Gly Ser 
            180                 185                 190         
His Phe Leu Thr Gly Ile Val Met Gly Gly Arg Ala Ile Leu Ala Ala 
        195                 200                 205             
Ser Thr Asn Lys Leu Arg Val Lys Arg Asp Tyr Ser Val Ser Val Val 
    210                 215                 220                 
Ala Lys Ala Ser Tyr Glu Gly Leu Thr Gly Gln Leu Ser Ala Glu Ala 
225                 230                 235                 240 
Lys Ala Lys Tyr Gly Glu Ser Ile Ser Ser Phe Thr Gln Tyr Ser Asn 
                245                 250                 255     
Thr His Gln Glu Val Arg Gly Gly Asp Gly Thr Lys Ala His Gly Val 
            260                 265                 270         
Phe Glu Gly Lys Ala Gly Phe Gln Ala Trp Val Asp Ser Val Gly Thr 
        275                 280                 285             
Ser Pro Asp Phe Val Asp Phe Val Pro Thr Ile Pro Met Gln Glu Ile 
    290                 295                 300                 
Trp Thr Leu Cys Ser Ser Glu Ala Gln Ala Glu Ala Met Arg Lys His 
305                 310                 315                 320 
Tyr Asp Asp Val Trp Ala Pro Ala Gln Ser Glu Lys Tyr Arg Val Lys 
                325                 330                 335     
Ala Asn Tyr Ile Asp Gln Leu Val Val Ile Thr Gly Asp Ser Ser Thr 
            340                 345                 350         
Ile Glu Pro Pro Ala Gly Tyr Thr Lys Ile Pro Tyr Asp Leu Asn Ala 
        355                 360                 365             
Gly Ala Lys Gly Asp Phe Ile Tyr Leu Cys Tyr His Glu Gln Ala Trp 
    370                 375                 380                 
Tyr Pro Asp Asn Thr Lys Pro Ala Val Thr Ala Ile Lys Ile Ile Tyr 
385                 390                 395                 400 
Asp Arg Glu Pro Val Pro Thr Gly Tyr Thr Lys Leu Pro Gln Asp Leu 
                405                 410                 415     
Asn Lys Gly Ala Gly Gly Asp Asp Val Phe Leu Cys Tyr Lys Thr Glu 
            420                 425                 430         
Ala Tyr Asn Thr Asp Thr Ala Ile Asn Lys Ile Thr Val Ile Gly Gly 
        435                 440                 445             
Asn Asn Ala Asp Ile Asn Ala Pro Tyr Gly Tyr Leu Lys Val Pro Gly 
    450                 455                 460                 
Asp Leu Asn Arg Gly Ala Gly Gly Asn Phe Ile Tyr Ala Cys Thr Phe 
465                 470                 475                 480 
Val Gly Lys 
            

<210>  155
<211>  483
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  155
Met Glu His Val Asp Leu Pro Thr Gly Leu Val Lys Phe Ser Ser Asn 
1               5                   10                  15      
His His Leu Gln Leu Leu Arg Asp Thr Ala Asp Leu Ser Glu Ser Val 
            20                  25                  30          
Leu Pro Gly Val Glu Ala Ile Gly Leu Gly Tyr Asn Pro Phe Leu Gly 
        35                  40                  45              
Tyr Ala Gly Val Gly Ser Gly Thr Val Gln Leu Phe Asp Trp Asn Asn 
    50                  55                  60                  
Ala Lys Lys Lys Lys Val Ser Phe Lys Pro Glu Phe Val Val Pro Glu 
65                  70                  75                  80  
Ile Val Asp Val Gln Gln Asn Asp Ser Ala Ser Tyr Thr Asn Ile Ser 
                85                  90                  95      
Gly Asn Thr Val Thr Glu Tyr Gln Arg Ser Leu Ala Val Ser Val Ala 
            100                 105                 110         
Ile Glu Gly Arg Tyr Asn Phe Phe Ser Gly Ser Leu Ser Thr Asp Tyr 
        115                 120                 125             
Asp Glu Asn Ser Leu Arg Asn Ala Glu Asn Glu Phe Thr Arg Ile Gln 
    130                 135                 140                 
Gln Ser Ile Asn Leu Trp Ser Leu Arg Leu Pro Ser Val Lys Ser Leu 
145                 150                 155                 160 
Arg Asp Leu Met Leu Pro His Met Arg Glu Gln Leu Asp Glu Leu Asp 
                165                 170                 175     
Val Lys Asn Pro Ser Ala Ile Ser Arg Phe Phe Asp Arg Val Gly Ser 
            180                 185                 190         
His Phe Leu Thr Gly Ile Val Met Gly Gly Arg Ala Ile Leu Ala Ala 
        195                 200                 205             
Ser Thr Asn Lys Leu Lys Val Lys Arg Asp Tyr Ser Val Ser Val Ile 
    210                 215                 220                 
Ala Lys Ala Ser Tyr Glu Gly Leu Thr Gly Gln Leu Ser Ala Glu Ala 
225                 230                 235                 240 
Lys Ala Lys Tyr Gly Glu Ser Ile Ser Ser Phe Thr Gln Tyr Ser Ser 
                245                 250                 255     
Thr His Gln Glu Val Arg Gly Gly Asp Gly Thr Lys Ala His Gly Val 
            260                 265                 270         
Phe Glu Gly Lys Ala Gly Phe Gln Ala Trp Val Asp Ser Val Gly Thr 
        275                 280                 285             
Ser Pro Asp Phe Val Asp Phe Val Pro Thr Ile Pro Met Leu Glu Ile 
    290                 295                 300                 
Trp Thr Leu Cys Ser Ser Glu Ala Gln Ala Glu Ala Met Arg Lys His 
305                 310                 315                 320 
Tyr Asp Asp Val Trp Ala Pro Ala Gln Ser Glu Lys Tyr Arg Val Lys 
                325                 330                 335     
Ala Asn Tyr Ile Asp Gln Leu Val Val Ile Thr Gly Gly Ser Ser Thr 
            340                 345                 350         
Ile Glu Pro Pro Val Gly Tyr Ser Lys Ile Glu Tyr Asp Leu Asn Ala 
        355                 360                 365             
Gly Ala Lys Gly Asp Phe Ile Tyr Leu Cys Tyr His Glu Gln Thr Trp 
    370                 375                 380                 
Gln Ala Asp Arg Pro Lys Asp Ala Val Thr Asp Ile Arg Ile Ile Phe 
385                 390                 395                 400 
Asn Lys Glu Pro Thr Pro Pro Gly Tyr Thr Lys Leu Pro Gln Asp Leu 
                405                 410                 415     
Asn Lys Gly Ala Gly Gly Asp Asp Val Phe Leu Cys Tyr Lys Thr Glu 
            420                 425                 430         
Ala Tyr Asn Thr Asp Thr Ala Ile Asn Lys Val Thr Val Ile Gly Gly 
        435                 440                 445             
Asn Asn Ala Asp Ile Asn Ala Pro Tyr Gly Tyr Leu Lys Val Pro Gly 
    450                 455                 460                 
Asp Leu Asn Arg Gly Ala Gly Gly Asn Phe Ile Tyr Ala Cys Thr Phe 
465                 470                 475                 480 
Val Gly Lys 
            

<210>  156
<211>  483
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  156
Met Glu Asn Ile Asp Leu Pro Gln Gly Leu Val Asn Phe Ser Thr Gln 
1               5                   10                  15      
His Leu Gln Leu Ile Arg Phe Lys Ala Gly Leu Asn Glu Thr Val Leu 
            20                  25                  30          
Pro Gly Val Glu Ala Ile Gly Leu Gly Tyr Asn Pro Phe Ile Ser Tyr 
        35                  40                  45              
Ala Ser Val Asn Ser Gly Ala Val Gln Leu Phe Asp Trp Ala Thr Ala 
    50                  55                  60                  
Lys Lys Arg Glu Val Pro Phe Lys Ala Gly Tyr Phe Val Pro Glu Ile 
65                  70                  75                  80  
Val Asp Val Gln Gln Asn Asp Ser Ala Thr Tyr Thr Asn Val Ser Gly 
                85                  90                  95      
Asn Thr Ile Ser Glu Tyr Gln Arg Ser Leu Ala Thr Ser Val Ala Ile 
            100                 105                 110         
Glu Gly Arg Tyr Asn Phe Phe Ser Gly Ser Leu Ser Thr Asp Phe Asp 
        115                 120                 125             
Ser Asn Ser Leu Arg Asn Ala Glu Asn Glu Phe Thr Arg Ile Gln Gln 
    130                 135                 140                 
Ser Ile Asn Leu Trp Ser Leu Arg Leu Pro Ser Val Lys Ser Leu Arg 
145                 150                 155                 160 
Glu Leu Met Leu Pro His Met Arg Gln Gln Leu Asp Glu Leu Asn Val 
                165                 170                 175     
Asn Asp Pro Lys Ala Ile Ser Arg Tyr Phe Asp Arg Val Gly Ser His 
            180                 185                 190         
Phe Leu Thr Gly Ile Val Met Gly Gly Arg Ala Ile Leu Thr Ala Ser 
        195                 200                 205             
Thr Asn Lys Leu Lys Val Lys Arg Asp Tyr Ser Val Ser Val Val Ala 
    210                 215                 220                 
Lys Ala Ser Tyr Glu Gly Leu Thr Gly Gln Leu Ser Ala Glu Ala Lys 
225                 230                 235                 240 
Ala Lys Tyr Gly Glu Ser Ile Ser Ser Phe Thr Gln Tyr Ser Ser Thr 
                245                 250                 255     
His Gln Glu Val Arg Gly Gly Asp Gly Thr Lys Ala His Gly Val Phe 
            260                 265                 270         
Ser Gly Lys Lys Glu Asp Phe Gln Ala Trp Val Asp Ser Val Gly Thr 
        275                 280                 285             
Ser Pro Asp Phe Val Asp Phe Val Pro Thr Ile Pro Met Gln Glu Ile 
    290                 295                 300                 
Trp Ser Leu Cys Lys Thr Asp Ser Gln Ala Glu Ala Met Lys Arg His 
305                 310                 315                 320 
Phe Asp Thr Val Trp Ala Arg Glu Gln Ser Asp Lys Tyr Arg Ile Lys 
                325                 330                 335     
Ala Asn Tyr Ile Asp Gln Leu Val Val Ile Thr Gly Gly Ser Ser Thr 
            340                 345                 350         
Ile Glu Pro Pro Val Gly Tyr Ser Lys Ile Glu Tyr Asp Leu Asn Ala 
        355                 360                 365             
Gly Ala Gly Gly Asp Phe Ile Tyr Leu Cys Tyr His Glu Gln Thr Trp 
    370                 375                 380                 
Gln Ala Asp Arg Pro Lys Asp Ala Val Thr Asp Ile Arg Ile Ile Phe 
385                 390                 395                 400 
Asn Lys Glu Pro Thr Pro Pro Gly Tyr Thr Lys Leu Pro Gln Asp Leu 
                405                 410                 415     
Asn Lys Gly Ala Gly Gly Asp Asp Val Phe Leu Cys Tyr Lys Thr Glu 
            420                 425                 430         
Ala Tyr Asn Thr Asp Thr Ala Ile Asn Lys Val Thr Val Ile Gly Gly 
        435                 440                 445             
Asn Asn Ala Asp Ile Asn Ala Pro Tyr Gly Tyr Leu Lys Val Pro Gly 
    450                 455                 460                 
Asp Leu Asn Arg Gly Ala Gly Gly Asn Phe Ile Tyr Ala Cys Thr Phe 
465                 470                 475                 480 
Val Gly Lys 
            

<210>  157
<211>  484
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  157
Met Glu His Val Asp Leu Pro Thr Gly Leu Val Lys Phe Ser Ser Asn 
1               5                   10                  15      
His His Leu Gln Leu Leu Arg Asp Thr Ala Asp Leu Ser Glu Ser Val 
            20                  25                  30          
Leu Pro Gly Val Glu Ala Ile Gly Leu Gly Tyr Asn Pro Phe Leu Gly 
        35                  40                  45              
Tyr Ala Gly Val Gly Ser Gly Thr Val Gln Leu Phe Asp Trp Asn Asn 
    50                  55                  60                  
Ala Lys Lys Lys Lys Val Ser Phe Lys Pro Glu Phe Val Val Pro Glu 
65                  70                  75                  80  
Ile Val Asp Val Gln Gln Asn Asp Ser Ala Ser Tyr Thr Asn Ile Ser 
                85                  90                  95      
Gly Asn Thr Val Thr Glu Tyr Gln Arg Ser Leu Ala Val Ser Val Ala 
            100                 105                 110         
Ile Glu Gly Arg Tyr Asn Phe Phe Ser Gly Ser Leu Ser Thr Asp Phe 
        115                 120                 125             
Asp Ser Asn Ser Leu Arg Asn Ala Glu Asn Glu Phe Thr Arg Ile Gln 
    130                 135                 140                 
Gln Ser Ile Asn Leu Trp Ser Leu Arg Leu Pro Ser Val Lys Ser Leu 
145                 150                 155                 160 
Arg Glu Leu Met Leu Pro His Met Arg Gln Gln Leu Asp Glu Leu Asn 
                165                 170                 175     
Val Asn Asp Pro Lys Ala Ile Ser Arg Tyr Phe Asp Arg Val Gly Ser 
            180                 185                 190         
His Phe Leu Thr Gly Ile Val Met Gly Gly Arg Ala Ile Leu Ala Ser 
        195                 200                 205             
Ser Thr Asn Lys Leu Arg Val Lys Arg Asp Tyr Ser Val Ser Val Val 
    210                 215                 220                 
Ala Lys Ala Ser Tyr Glu Gly Leu Thr Gly Gln Leu Ser Ala Glu Ala 
225                 230                 235                 240 
Lys Ala Lys Tyr Gly Glu Ser Ile Ser Ser Phe Thr Gln Tyr Ser Asn 
                245                 250                 255     
Thr His Gln Glu Val Arg Gly Gly Asp Gly Ala Lys Ala His Gly Val 
            260                 265                 270         
Phe Ser Gly Lys Lys Glu Asp Phe Gln Ala Trp Val Asp Ser Val Ser 
        275                 280                 285             
Ala Ser Pro Asp Phe Val Asp Phe Val Pro Thr Ile Pro Met Leu Glu 
    290                 295                 300                 
Ile Trp Thr Leu Cys Lys Thr Asp Ser Gln Ala Glu Ala Met Lys Arg 
305                 310                 315                 320 
His Phe Asp Thr Val Trp Ala Pro Ala Gln Ser Glu Lys Tyr Arg Val 
                325                 330                 335     
Lys Ala Asn Tyr Ile Asp Gln Leu Val Val Ile Thr Gly Gly Ser Ser 
            340                 345                 350         
Thr Ile Glu Pro Pro Val Gly Tyr Thr Lys Ile Pro Tyr Asp Leu Asn 
        355                 360                 365             
Ala Gly Ala Lys Gly Asp Phe Ile Tyr Leu Cys Tyr His Glu Gln Ala 
    370                 375                 380                 
Trp Tyr Pro Asp Asn Thr Lys Pro Ala Val Thr Ala Ile Lys Ile Ile 
385                 390                 395                 400 
Tyr Asp Arg Glu Pro Val Pro Thr Gly Tyr Ile Lys Leu Pro Gln Asp 
                405                 410                 415     
Leu Asn Lys Gly Ala Gly Gly Ala Asp Ile Tyr Leu Cys Tyr Lys Leu 
            420                 425                 430         
Glu Gly Tyr Asn Thr Asp Thr Ala Ile Asn Lys Ile Thr Val Ile Gly 
        435                 440                 445             
Gly Asn Asn Ala Asp Ile Asn Ala Pro Tyr Gly Tyr Leu Lys Val Pro 
    450                 455                 460                 
Gly Asp Leu Asn Arg Gly Ala Gly Gly Asn Phe Ile Tyr Ala Cys Thr 
465                 470                 475                 480 
Phe Val Gly Lys 
                

<210>  158
<211>  484
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  158
Met Glu His Val Asp Leu Pro Thr Gly Leu Val Lys Phe Ser Ser Asn 
1               5                   10                  15      
His His Leu Gln Leu Leu Arg Asp Thr Ala Asp Leu Ser Glu Ser Val 
            20                  25                  30          
Leu Pro Gly Val Glu Ala Ile Gly Leu Gly Tyr Asn Pro Phe Leu Gly 
        35                  40                  45              
Tyr Ala Gly Val Gly Ser Gly Thr Val Gln Leu Phe Asp Trp Asn Asn 
    50                  55                  60                  
Ala Lys Lys Lys Lys Val Ser Phe Lys Pro Glu Phe Val Val Pro Glu 
65                  70                  75                  80  
Ile Val Asp Val Gln Gln Asn Asp Ser Ala Thr Tyr Thr Asn Val Ser 
                85                  90                  95      
Gly Asn Thr Ile Ser Glu Tyr Gln Arg Ser Leu Ala Val Ser Val Ala 
            100                 105                 110         
Ile Glu Gly Lys Tyr Asn Phe Phe Ser Gly Ser Leu Ser Thr Asp Tyr 
        115                 120                 125             
Asp Glu Asn Ser Leu Arg Asn Ala Glu Asn Glu Phe Thr Arg Ile Gln 
    130                 135                 140                 
Gln Ser Ile Asn Leu Trp Ser Leu Arg Leu Pro Ser Val Lys Ser Leu 
145                 150                 155                 160 
Arg Asp Leu Met Leu Pro His Met Arg Glu Gln Leu Asp Glu Leu Asp 
                165                 170                 175     
Val Lys Asn Pro Ser Ala Ile Ser Arg Phe Phe Asp Arg Val Gly Ser 
            180                 185                 190         
His Phe Leu Thr Gly Ile Val Met Gly Gly Arg Ala Ile Leu Ala Ala 
        195                 200                 205             
Ser Thr Asn Lys Leu Arg Val Lys Arg Asp Tyr Ser Val Ser Val Val 
    210                 215                 220                 
Ala Lys Ala Ser Tyr Glu Gly Leu Thr Gly Gln Leu Ser Ala Glu Ala 
225                 230                 235                 240 
Lys Ala Lys Tyr Gly Glu Ser Ile Ser Ser Phe Thr Gln Tyr Ser Asn 
                245                 250                 255     
Thr His Gln Glu Val Arg Gly Gly Asp Gly Ala Lys Ala His Gly Val 
            260                 265                 270         
Phe Ser Gly Lys Lys Glu Asp Phe Gln Ala Trp Val Asp Ser Val Ser 
        275                 280                 285             
Ala Ser Pro Asp Phe Val Asp Phe Val Pro Thr Ile Pro Met Gln Glu 
    290                 295                 300                 
Ile Trp Thr Leu Cys Lys Thr Asp Ser Gln Ala Glu Ala Met Lys Arg 
305                 310                 315                 320 
His Phe Asp Thr Val Trp Ala Arg Glu Gln Ser Asp Lys Tyr Arg Ile 
                325                 330                 335     
Lys Ala Asn Tyr Ile Asp Gln Leu Val Val Ile Thr Gly Gly Ser Ser 
            340                 345                 350         
Thr Ile Glu Pro Pro Val Gly Tyr Ser Lys Ile Glu Tyr Asp Leu Asn 
        355                 360                 365             
Ala Gly Ala Gly Gly Asp Phe Ile Tyr Leu Cys Tyr His Glu Gln Ala 
    370                 375                 380                 
Trp Tyr Pro Asp Asn Thr Lys Pro Ala Val Thr Asp Ile Arg Ile Ile 
385                 390                 395                 400 
Phe Asn Lys Glu Pro Thr Pro Pro Gly Tyr Thr Lys Leu Pro Gln Asp 
                405                 410                 415     
Leu Asn Lys Gly Ala Gly Gly Asp Asp Val Phe Leu Cys Tyr Lys Thr 
            420                 425                 430         
Glu Ala Tyr Asn Thr Asp Thr Ala Ile Asn Lys Val Thr Val Ile Gly 
        435                 440                 445             
Gly Asn Asn Pro Asp Ile Asn Ala Pro Tyr Gly Tyr Leu Lys Val Pro 
    450                 455                 460                 
Gly Asp Leu Asn Arg Gly Ala Gly Gly Asn Phe Ile Tyr Ala Cys Thr 
465                 470                 475                 480 
Phe Val Gly Lys 
                

<210>  159
<211>  482
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  159
Met Glu Asn Ile Asp Leu Pro Gln Gly Leu Val Asn Phe Ser Thr Gln 
1               5                   10                  15      
His Leu Gln Leu Ile Arg Phe Lys Ala Gly Leu Asn Glu Thr Val Leu 
            20                  25                  30          
Pro Gly Val Glu Ala Ile Gly Leu Gly Tyr Asn Pro Phe Ile Ser Tyr 
        35                  40                  45              
Ala Ser Val Asn Ser Gly Ala Val Gln Leu Phe Asp Trp Ala Thr Ala 
    50                  55                  60                  
Lys Lys Arg Glu Val Pro Phe Lys Ala Gly Tyr Phe Val Pro Glu Ile 
65                  70                  75                  80  
Val Asp Val Gln Gln Asn Asp Ser Ala Thr Tyr Thr Asn Val Ser Gly 
                85                  90                  95      
Asn Thr Ile Ser Glu Tyr Gln Arg Ser Leu Ala Thr Ser Val Ala Ile 
            100                 105                 110         
Glu Gly Arg Tyr Asn Phe Phe Ser Gly Ser Leu Ser Thr Asp Tyr Asp 
        115                 120                 125             
Glu Asn Ser Leu Arg Asn Ala Glu Asn Glu Phe Thr Arg Ile Gln Gln 
    130                 135                 140                 
Ser Ile Asn Leu Trp Ser Leu Arg Leu Pro Ser Val Lys Ser Leu Arg 
145                 150                 155                 160 
Glu Leu Met Leu Pro His Met Arg Gln Gln Leu Asp Glu Leu Asn Val 
                165                 170                 175     
Asn Asp Pro Lys Ala Ile Ser Arg Tyr Phe Asp Arg Val Gly Ser His 
            180                 185                 190         
Phe Leu Thr Gly Ile Val Met Gly Gly Arg Ala Ile Leu Ala Ser Ser 
        195                 200                 205             
Thr Asn Lys Leu Arg Val Lys Arg Asp Tyr Ser Val Ser Val Val Ala 
    210                 215                 220                 
Lys Ala Ser Tyr Glu Gly Leu Thr Gly Gln Leu Ser Ala Glu Ala Lys 
225                 230                 235                 240 
Ala Lys Tyr Gly Glu Ser Ile Ser Ser Phe Thr Gln Tyr Ser Asn Thr 
                245                 250                 255     
His Gln Glu Val Arg Gly Gly Asp Gly Ala Lys Ala His Gly Val Phe 
            260                 265                 270         
Glu Gly Lys Ala Gly Phe Gln Ala Trp Val Asp Ser Val Gly Thr Ser 
        275                 280                 285             
Pro Asp Phe Val Asp Phe Val Pro Thr Ile Pro Met Leu Glu Ile Trp 
    290                 295                 300                 
Ser Leu Cys Lys Thr Asp Ser Gln Ala Glu Ala Met Lys Arg His Phe 
305                 310                 315                 320 
Asp Thr Val Trp Ala Arg Glu Gln Ser Asp Lys Tyr Arg Ile Lys Ala 
                325                 330                 335     
Asn Tyr Ile Asp Gln Leu Val Val Ile Thr Gly Asp Ser Ser Thr Ile 
            340                 345                 350         
Glu Pro Pro Ala Gly Tyr Thr Lys Ile Pro Tyr Asp Leu Asn Ala Gly 
        355                 360                 365             
Ala Lys Gly Asp Phe Ile Tyr Leu Cys Tyr His Glu Gln Ala Trp Tyr 
    370                 375                 380                 
Pro Asp Asn Thr Lys Pro Ala Val Thr Ala Ile Lys Ile Ile Tyr Asp 
385                 390                 395                 400 
Arg Glu Pro Val Pro Thr Gly Tyr Ile Lys Leu Pro Gln Asp Leu Asn 
                405                 410                 415     
Lys Gly Ala Gly Gly Asp Asp Val Phe Leu Cys Tyr Lys Leu Glu Gly 
            420                 425                 430         
Tyr Asn Thr Asp Thr Ala Ile Asn Lys Ile Thr Val Ile Gly Gly Asn 
        435                 440                 445             
Asn Ala Asp Ile Asn Ala Pro Tyr Gly Tyr Glu Lys Val Pro Gly Asp 
    450                 455                 460                 
Leu Asn Arg Gly Ala Gly Gly Asn Phe Ile Tyr Ala Cys Thr Phe Val 
465                 470                 475                 480 
Asp Lys 
        

<210>  160
<211>  483
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  160
Met Glu Asn Ile Asp Leu Pro Gln Gly Leu Val Asn Phe Ser Thr Gln 
1               5                   10                  15      
His Leu Gln Leu Ile Arg Phe Lys Ala Gly Leu Asn Glu Thr Val Leu 
            20                  25                  30          
Pro Gly Val Glu Ala Ile Gly Leu Gly Tyr Asn Pro Phe Ile Ser Tyr 
        35                  40                  45              
Ala Ser Val Asn Ser Gly Ala Val Gln Leu Phe Asp Trp Ala Thr Ala 
    50                  55                  60                  
Lys Lys Arg Glu Val Pro Phe Lys Ala Gly Tyr Phe Val Pro Glu Ile 
65                  70                  75                  80  
Val Asp Val Gln Gln Asn Asp Ser Ala Thr Tyr Thr Asn Val Ser Gly 
                85                  90                  95      
Asn Thr Ile Ser Glu Tyr Gln Arg Ser Leu Ala Thr Ser Val Ala Ile 
            100                 105                 110         
Glu Gly Arg Tyr Asn Phe Phe Ser Gly Ser Leu Ser Thr Asp Phe Asp 
        115                 120                 125             
Ser Asn Ser Leu Arg Asn Ala Glu Asn Glu Phe Thr Arg Ile Gln Gln 
    130                 135                 140                 
Ser Ile Asn Leu Trp Ser Leu Arg Leu Pro Ser Val Lys Ser Leu Arg 
145                 150                 155                 160 
Glu Leu Met Leu Pro His Met Arg Gln Gln Leu Asp Glu Leu Asn Val 
                165                 170                 175     
Asn Asp Pro Lys Ala Ile Ser Arg Tyr Phe Asp Arg Val Gly Ser His 
            180                 185                 190         
Phe Leu Thr Gly Ile Val Met Gly Gly Arg Ala Ile Leu Ala Ser Ser 
        195                 200                 205             
Thr Asn Lys Leu Arg Val Lys Arg Asp Tyr Ser Val Ser Val Ile Ala 
    210                 215                 220                 
Lys Ala Ser Tyr Glu Gly Leu Thr Gly Gln Leu Ser Ala Glu Ala Arg 
225                 230                 235                 240 
Thr Lys Tyr Gly Glu Ser Met Ser Ser Phe Thr Gln Tyr Ser Ser Thr 
                245                 250                 255     
His Gln Glu Val Arg Gly Gly Asp Gly Ala Lys Ala His Gly Val Phe 
            260                 265                 270         
Ser Gly Lys Lys Glu Asp Phe Gln Ala Trp Val Asp Ser Val Ser Ala 
        275                 280                 285             
Ser Pro Asp Phe Val Asp Phe Val Pro Thr Ile Pro Met Gln Glu Ile 
    290                 295                 300                 
Trp Thr Leu Cys Ser Ser Glu Ala Gln Ala Glu Ala Met Arg Lys His 
305                 310                 315                 320 
Tyr Asp Asp Val Trp Ala Pro Ala Gln Ser Glu Lys Tyr Arg Val Lys 
                325                 330                 335     
Ala Asn Tyr Ile Asp Gln Leu Val Val Ile Thr Gly Asp Ser Ser Thr 
            340                 345                 350         
Ile Glu Pro Pro Val Gly Tyr Ser Lys Ile Glu Tyr Asp Leu Asn Ala 
        355                 360                 365             
Gly Ala Gly Gly Asp Phe Ile Tyr Leu Cys Tyr His Glu Gln Thr Trp 
    370                 375                 380                 
Gln Ala Asp Arg Pro Lys Asp Ala Val Thr Asp Ile Arg Ile Ile Phe 
385                 390                 395                 400 
Asn Lys Glu Pro Thr Pro Pro Gly Tyr Thr Lys Leu Pro Gln Asp Leu 
                405                 410                 415     
Asn Lys Gly Ala Gly Gly Ala Asp Ile Tyr Leu Cys Tyr Lys Leu Glu 
            420                 425                 430         
Gly Tyr Asn Thr Asp Thr Ala Ile Asn Lys Ile Thr Val Ile Ser Gly 
        435                 440                 445             
Asn Asn Ala Asp Ile Asn Ala Pro Tyr Gly Tyr Leu Lys Val Pro Gly 
    450                 455                 460                 
Asp Leu Asn Arg Gly Ala Gly Gly Asn Phe Ile Tyr Ala Cys Thr Phe 
465                 470                 475                 480 
Val Gly Lys 
            

<210>  161
<211>  482
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  161
Met Glu Asn Ile Asp Leu Pro Gln Gly Leu Val Asn Phe Ser Thr Gln 
1               5                   10                  15      
His Leu Gln Leu Ile Arg Phe Lys Ala Gly Leu Asn Glu Thr Val Leu 
            20                  25                  30          
Pro Gly Val Glu Ala Ile Gly Leu Gly Tyr Asn Pro Phe Ile Ser Tyr 
        35                  40                  45              
Ala Ser Val Asn Ser Gly Ala Val Gln Leu Phe Asp Trp Ala Thr Ala 
    50                  55                  60                  
Lys Lys Arg Glu Val Pro Phe Lys Ala Gly Tyr Phe Val Pro Glu Ile 
65                  70                  75                  80  
Val Asp Val Gln Gln Asn Asp Ser Ala Ser Tyr Thr Asn Val Ser Gly 
                85                  90                  95      
Asn Thr Ile Ser Glu Tyr Gln Arg Ser Leu Ala Thr Ser Val Ala Ile 
            100                 105                 110         
Glu Gly Arg Tyr Asn Phe Phe Ser Gly Ser Leu Ser Thr Asp Phe Asp 
        115                 120                 125             
Ser Asn Ser Leu Arg Asn Ala Glu Asn Glu Phe Thr Arg Ile Gln Gln 
    130                 135                 140                 
Ser Ile Asn Leu Trp Ser Leu Arg Leu Pro Ser Val Lys Ser Leu Arg 
145                 150                 155                 160 
Asp Leu Met Leu Pro His Met Arg Gln Gln Leu Asp Glu Leu Asn Val 
                165                 170                 175     
Asn Asp Pro Lys Ala Ile Ser Arg Tyr Phe Asp Arg Val Gly Ser His 
            180                 185                 190         
Phe Leu Thr Gly Ile Val Met Gly Gly Arg Ala Ile Leu Ala Ser Ser 
        195                 200                 205             
Thr Asn Lys Leu Arg Val Lys Arg Asp Tyr Ser Val Ser Val Ile Ala 
    210                 215                 220                 
Lys Ala Ser Tyr Glu Gly Leu Thr Gly Gln Leu Ser Ala Glu Ala Arg 
225                 230                 235                 240 
Thr Lys Tyr Gly Glu Ser Met Ser Ser Phe Thr Gln Tyr Ser Ser Thr 
                245                 250                 255     
His Gln Glu Val Arg Gly Gly Asp Gly Thr Lys Ala His Gly Val Phe 
            260                 265                 270         
Glu Gly Lys Ala Gly Phe Gln Ala Trp Val Asp Ser Val Gly Thr Ser 
        275                 280                 285             
Pro Asp Phe Val Asp Phe Val Pro Thr Ile Pro Met Leu Glu Ile Trp 
    290                 295                 300                 
Thr Leu Cys Ser Ser Glu Ala Gln Ala Glu Ala Met Arg Lys His Tyr 
305                 310                 315                 320 
Asp Asp Val Trp Ala Pro Ala Gln Ser Glu Lys Tyr Arg Val Lys Ala 
                325                 330                 335     
Asn Cys Ile Asp Gln Leu Val Val Ile Thr Gly Asp Ser Ser Thr Ile 
            340                 345                 350         
Glu Pro Pro Val Gly Tyr Ser Lys Ile Glu Tyr Asp Leu Asn Ala Gly 
        355                 360                 365             
Ala Gly Gly Asp Phe Ile Tyr Leu Cys Tyr His Glu Gln Thr Trp Gln 
    370                 375                 380                 
Ala Asp Arg Pro Lys Asp Ala Val Thr Asp Ile Arg Ile Ile Phe Asn 
385                 390                 395                 400 
Lys Glu Pro Thr Pro Pro Gly Tyr Thr Lys Leu Pro Gln Asp Leu Asn 
                405                 410                 415     
Lys Gly Ala Gly Gly Asp Asp Val Phe Leu Cys Tyr Lys Thr Glu Ala 
            420                 425                 430         
Tyr Asn Thr Asp Thr Ala Ile Asn Lys Val Thr Val Ile Gly Gly Asn 
        435                 440                 445             
Asn Ala Asp Ile Asn Ala Pro Tyr Gly Tyr Leu Lys Val Pro Gly Asp 
    450                 455                 460                 
Leu Asn Arg Gly Ala Gly Gly Asn Phe Ile Tyr Ala Cys Thr Phe Val 
465                 470                 475                 480 
Gly Lys 
        

<210>  162
<211>  483
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  162
Met Glu His Val Asp Leu Pro Thr Gly Leu Val Lys Phe Ser Ser Asn 
1               5                   10                  15      
His His Leu Gln Leu Leu Arg Asp Thr Ala Asp Leu Ser Glu Ser Val 
            20                  25                  30          
Leu Pro Gly Val Glu Ala Ile Gly Leu Gly Tyr Asn Pro Phe Leu Gly 
        35                  40                  45              
Tyr Ala Gly Val Gly Ser Gly Thr Val Gln Leu Phe Asp Trp Asn Asn 
    50                  55                  60                  
Ala Lys Lys Lys Lys Val Ser Phe Lys Pro Glu Phe Val Val Pro Glu 
65                  70                  75                  80  
Ile Val Asp Val Gln Gln Asn Asp Ser Ala Ser Tyr Thr Asn Ile Ser 
                85                  90                  95      
Gly Asn Thr Val Thr Glu Tyr Gln Arg Ser Leu Ala Val Ser Val Ala 
            100                 105                 110         
Ile Glu Gly Arg Tyr Asn Phe Phe Ser Gly Ser Leu Ser Thr Asp Tyr 
        115                 120                 125             
Asp Glu Asn Ser Leu Arg Asn Ala Glu Asn Glu Phe Thr Arg Ile Gln 
    130                 135                 140                 
Gln Ser Ile Asn Leu Trp Ser Leu Arg Leu Pro Ser Val Lys Ser Leu 
145                 150                 155                 160 
Arg Asp Leu Met Leu Pro His Met Arg Glu Gln Leu Asp Glu Leu Asp 
                165                 170                 175     
Val Lys Asn Pro Ser Ala Ile Ser Arg Phe Phe Asp Arg Val Gly Ser 
            180                 185                 190         
His Phe Leu Thr Gly Ile Val Met Gly Gly Arg Ala Ile Leu Ala Ala 
        195                 200                 205             
Ser Thr Asn Lys Leu Lys Val Lys Arg Asp Tyr Ser Val Ser Val Val 
    210                 215                 220                 
Ala Lys Ala Ser Tyr Glu Gly Leu Thr Gly Gln Leu Ser Ala Glu Ala 
225                 230                 235                 240 
Lys Ala Lys Tyr Gly Glu Ser Ile Ser Ser Phe Thr Gln Tyr Ser Asn 
                245                 250                 255     
Thr His Gln Glu Val Arg Gly Gly Asp Gly Ala Lys Ala His Gly Val 
            260                 265                 270         
Phe Glu Gly Lys Ala Gly Phe Gln Ala Trp Val Asp Ser Val Ser Ala 
        275                 280                 285             
Ser Pro Asp Phe Val Asp Phe Val Pro Thr Ile Pro Met Leu Glu Ile 
    290                 295                 300                 
Trp Ser Leu Cys Lys Thr Asp Ser Arg Ala Glu Ala Met Lys Arg His 
305                 310                 315                 320 
Phe Asp Thr Val Trp Ala Arg Glu Gln Ser Asp Lys Tyr Arg Ile Lys 
                325                 330                 335     
Ala Asn Tyr Ile Asp Gln Leu Val Val Ile Thr Gly Gly Ser Ser Thr 
            340                 345                 350         
Ile Glu Pro Pro Val Gly Tyr Ser Lys Ile Glu Tyr Asp Leu Asn Ala 
        355                 360                 365             
Gly Ala Gly Gly Asp Phe Ile Tyr Leu Cys Tyr His Glu Gln Thr Trp 
    370                 375                 380                 
Tyr Pro Asp Asn Thr Lys Pro Ala Val Thr Ala Ile Lys Ile Ile Tyr 
385                 390                 395                 400 
Asp Arg Glu Pro Val Pro Thr Gly Tyr Thr Lys Leu Pro Gln Asp Leu 
                405                 410                 415     
Asn Lys Gly Ala Gly Gly Asp Asp Val Phe Leu Cys Tyr Lys Thr Glu 
            420                 425                 430         
Ala Tyr Asn Thr Asp Thr Ala Ile Asn Lys Val Thr Val Ile Gly Gly 
        435                 440                 445             
Asn Asn Pro Asp Ile Asn Ala Pro Tyr Gly Tyr Glu Lys Val Pro Gly 
    450                 455                 460                 
Asp Leu Asn Lys Gly Ala Lys Gly Asn Phe Ile Tyr Ala Cys Thr Phe 
465                 470                 475                 480 
Val Gly Lys 
            

<210>  163
<211>  483
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  163
Met Glu Asn Ile Asp Leu Pro Gln Gly Leu Val Asn Phe Ser Thr Gln 
1               5                   10                  15      
His Leu Gln Leu Ile Arg Phe Lys Ala Gly Leu Asn Glu Thr Val Leu 
            20                  25                  30          
Pro Gly Val Glu Ala Ile Gly Leu Gly Tyr Asn Pro Phe Ile Ser Tyr 
        35                  40                  45              
Ala Ser Val Asn Ser Gly Ala Val Gln Leu Phe Asp Trp Ala Thr Ala 
    50                  55                  60                  
Lys Lys Arg Glu Val Pro Phe Lys Ala Gly Tyr Phe Val Pro Glu Ile 
65                  70                  75                  80  
Val Asp Val Gln Gln Asn Asp Ser Ala Thr Tyr Thr Asn Val Ser Gly 
                85                  90                  95      
Asn Thr Ile Ser Glu Tyr Gln Arg Ser Leu Ala Thr Ser Val Ala Ile 
            100                 105                 110         
Glu Gly Arg Tyr Asn Phe Phe Ser Gly Ser Leu Ser Thr Asp Tyr Asp 
        115                 120                 125             
Glu Asn Ser Leu Arg Asn Ala Glu Asn Glu Phe Thr Arg Ile Gln Gln 
    130                 135                 140                 
Ser Ile Asn Leu Trp Ser Leu Arg Leu Pro Ser Val Lys Ser Leu Arg 
145                 150                 155                 160 
Asp Leu Met Leu Pro His Met Arg Glu Gln Leu Asp Glu Leu Asn Val 
                165                 170                 175     
Asn Asp Pro Lys Ala Ile Ser Arg Tyr Phe Asp Arg Val Gly Ser His 
            180                 185                 190         
Phe Leu Thr Gly Ile Val Met Gly Gly Arg Ala Ile Leu Ala Ser Ser 
        195                 200                 205             
Thr Asn Lys Leu Arg Val Lys Arg Asp Tyr Ser Val Ser Val Val Ala 
    210                 215                 220                 
Lys Ala Ser Tyr Glu Gly Leu Thr Gly Gln Leu Ser Ala Glu Ala Lys 
225                 230                 235                 240 
Ala Lys Tyr Gly Glu Ser Ile Ser Ser Phe Thr Gln Tyr Ser Asn Thr 
                245                 250                 255     
His Gln Glu Val Arg Gly Gly Asp Gly Ala Lys Ala His Gly Val Phe 
            260                 265                 270         
Ser Gly Lys Lys Glu Asp Phe Gln Ala Trp Val Asp Ser Val Ser Ala 
        275                 280                 285             
Ser Pro Asp Phe Val Asp Phe Val Pro Thr Ile Pro Met Gln Glu Ile 
    290                 295                 300                 
Trp Thr Leu Cys Ser Ser Glu Ala Gln Ala Glu Ala Met Arg Lys His 
305                 310                 315                 320 
Tyr Asp Asp Val Trp Ala Pro Ala Gln Ser Glu Lys Tyr Arg Val Lys 
                325                 330                 335     
Ala Asn Tyr Ile Asp Gln Leu Val Val Ile Thr Gly Gly Ser Ser Thr 
            340                 345                 350         
Ile Glu Pro Pro Val Gly Tyr Ser Lys Ile Glu Tyr Asp Leu Asn Ala 
        355                 360                 365             
Gly Ala Gly Gly Asp Phe Ile Tyr Leu Cys Tyr His Glu Gln Thr Trp 
    370                 375                 380                 
Gln Ala Asp Arg Pro Lys Asp Ala Val Thr Ala Ile Lys Ile Ile Tyr 
385                 390                 395                 400 
Asp Arg Glu Pro Val Pro Thr Gly Tyr Ile Lys Leu Pro Gln Asp Leu 
                405                 410                 415     
Asn Lys Gly Ala Gly Gly Ala Asp Ile Tyr Leu Cys Tyr Lys Leu Glu 
            420                 425                 430         
Gly Tyr Asn Thr Asp Thr Ala Ile Asn Lys Ile Thr Val Ile Ser Gly 
        435                 440                 445             
Asn Asn Pro Asp Ile Asn Ala Pro Tyr Gly Tyr Glu Lys Val Pro Gly 
    450                 455                 460                 
Asp Leu Asn Lys Gly Ala Lys Gly Asn Phe Ile Tyr Ala Cys Thr Phe 
465                 470                 475                 480 
Val Gly Lys 
            

<210>  164
<211>  482
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  164
Met Glu Asn Ile Asp Leu Pro Gln Gly Leu Val Asn Phe Ser Thr Gln 
1               5                   10                  15      
His Leu Gln Leu Ile Arg Phe Lys Ala Gly Leu Asn Glu Thr Val Leu 
            20                  25                  30          
Pro Gly Val Glu Ala Ile Gly Leu Gly Tyr Asn Pro Phe Ile Ser Tyr 
        35                  40                  45              
Ala Ser Val Asn Ser Gly Ala Val Gln Leu Phe Asp Trp Ala Thr Ala 
    50                  55                  60                  
Lys Lys Arg Glu Val Pro Phe Lys Ala Gly Tyr Phe Val Pro Glu Ile 
65                  70                  75                  80  
Val Asp Val Gln Gln Asn Asp Ser Ala Thr Tyr Thr Asn Val Ser Gly 
                85                  90                  95      
Asn Thr Ile Ser Glu Tyr Gln Arg Ser Leu Ala Thr Ser Val Ala Ile 
            100                 105                 110         
Glu Gly Arg Tyr Asn Phe Phe Ser Gly Ser Leu Ser Thr Asp Tyr Asp 
        115                 120                 125             
Glu Asn Ser Leu Arg Asn Ala Glu Asn Glu Phe Thr Arg Ile Gln Gln 
    130                 135                 140                 
Ser Ile Asn Leu Trp Ser Leu Arg Leu Pro Ser Val Lys Ser Leu Arg 
145                 150                 155                 160 
Asp Leu Met Leu Pro His Met Arg Gln Gln Leu Asp Glu Leu Asn Val 
                165                 170                 175     
Asn Asp Pro Lys Ala Ile Ser Arg Tyr Phe Asp Arg Val Gly Ser His 
            180                 185                 190         
Phe Leu Thr Gly Ile Val Met Gly Gly Arg Ala Ile Leu Ala Ala Ser 
        195                 200                 205             
Thr Asn Lys Leu Lys Val Lys Arg Asp Tyr Ser Val Ser Val Ile Ala 
    210                 215                 220                 
Lys Ala Ser Tyr Glu Gly Leu Thr Gly Gln Leu Ser Ala Glu Ala Arg 
225                 230                 235                 240 
Thr Lys Tyr Gly Glu Ser Met Ser Ser Phe Thr Gln Tyr Ser Asn Thr 
                245                 250                 255     
His Gln Glu Val Arg Gly Gly Asp Gly Thr Lys Ala His Gly Val Phe 
            260                 265                 270         
Glu Gly Lys Ala Gly Phe Gln Ala Trp Val Asp Ser Val Ser Ala Ser 
        275                 280                 285             
Pro Asp Phe Val Asp Phe Val Pro Thr Ile Pro Met Gln Glu Ile Trp 
    290                 295                 300                 
Thr Leu Cys Ser Ser Glu Ala Gln Ala Glu Ala Met Arg Lys His Tyr 
305                 310                 315                 320 
Asp Asp Val Trp Ala Pro Ala Gln Ser Glu Lys Tyr Arg Val Lys Ala 
                325                 330                 335     
Asn Tyr Ile Asp Gln Leu Val Val Ile Thr Gly Gly Ser Ser Thr Ile 
            340                 345                 350         
Glu Pro Pro Val Gly Tyr Ser Lys Ile Glu Tyr Asp Leu Asn Ala Gly 
        355                 360                 365             
Ala Gly Gly Asp Phe Ile Tyr Leu Cys Tyr His Glu Gln Thr Trp Gln 
    370                 375                 380                 
Ala Asp Arg Pro Lys Asp Ala Val Thr Asp Ile Arg Ile Ile Phe Asn 
385                 390                 395                 400 
Lys Glu Pro Thr Pro Pro Gly Tyr Thr Lys Leu Pro Gln Asp Leu Asn 
                405                 410                 415     
Lys Gly Ala Gly Gly Asp Asp Val Phe Leu Cys Tyr Lys Thr Glu Ala 
            420                 425                 430         
Tyr Asn Thr Asp Thr Ala Ile Asn Lys Val Thr Val Ile Gly Gly Asn 
        435                 440                 445             
Asn Ala Asp Ile Asn Ala Pro Tyr Gly Tyr Glu Lys Val Pro Gly Asp 
    450                 455                 460                 
Leu Asn Lys Gly Ala Lys Gly Asn Phe Ile Tyr Ala Cys Thr Phe Val 
465                 470                 475                 480 
Gly Lys 
        

<210>  165
<211>  483
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  165
Met Glu His Val Asp Leu Pro Thr Gly Leu Val Lys Phe Ser Ser Asn 
1               5                   10                  15      
His His Leu Gln Leu Leu Arg Asp Thr Ala Asp Leu Ser Glu Ser Val 
            20                  25                  30          
Leu Pro Gly Val Glu Ala Ile Gly Leu Gly Tyr Asn Pro Phe Ile Ser 
        35                  40                  45              
Tyr Ala Ser Val Asn Ser Gly Ala Val Gln Leu Phe Asp Trp Ala Thr 
    50                  55                  60                  
Ala Lys Lys Arg Glu Val Pro Phe Lys Ala Gly Tyr Phe Val Pro Glu 
65                  70                  75                  80  
Ile Val Asp Val Gln Gln Asn Asp Ser Ala Thr Tyr Thr Asn Val Ser 
                85                  90                  95      
Gly Asn Thr Val Thr Glu Tyr Gln Arg Ser Leu Ala Val Ser Val Ala 
            100                 105                 110         
Ile Glu Gly Arg Tyr Asn Phe Phe Ser Gly Ser Leu Ser Thr Asp Phe 
        115                 120                 125             
Asp Ser Asn Ser Leu Arg Asn Ala Glu Asn Glu Phe Thr Arg Ile Gln 
    130                 135                 140                 
Gln Ser Ile Asn Leu Trp Ser Leu Arg Leu Pro Ser Val Lys Ser Leu 
145                 150                 155                 160 
Arg Glu Leu Met Leu Pro His Met Arg Glu Gln Leu Asp Glu Leu Asp 
                165                 170                 175     
Val Lys Asn Pro Ser Ala Ile Ser Arg Phe Phe Asp Arg Val Gly Ser 
            180                 185                 190         
His Phe Leu Thr Gly Ile Val Met Gly Gly Arg Ala Ile Leu Ala Ser 
        195                 200                 205             
Ser Thr Asn Lys Leu Arg Val Lys Arg Asp Tyr Ser Val Ser Val Ile 
    210                 215                 220                 
Ala Lys Ala Ser Tyr Glu Gly Leu Thr Gly Gln Leu Ser Ala Glu Ala 
225                 230                 235                 240 
Arg Thr Lys Tyr Gly Glu Ser Met Ser Ser Phe Thr Gln Tyr Ser Ser 
                245                 250                 255     
Thr His Gln Glu Val Arg Gly Gly Asp Gly Thr Lys Ala His Gly Val 
            260                 265                 270         
Phe Glu Gly Lys Ala Gly Phe Gln Ala Trp Val Asp Ser Val Gly Thr 
        275                 280                 285             
Ser Pro Asp Phe Val Asp Phe Val Pro Thr Ile Pro Met Leu Glu Ile 
    290                 295                 300                 
Trp Ser Leu Cys Lys Thr Asp Ser Gln Ala Glu Ala Met Lys Arg His 
305                 310                 315                 320 
Phe Asp Thr Val Trp Ala Arg Glu Gln Ser Asp Lys Tyr Arg Ile Lys 
                325                 330                 335     
Ala Asn Tyr Ile Asp Gln Leu Val Val Ile Thr Gly Asp Ser Ser Thr 
            340                 345                 350         
Ile Glu Pro Pro Ala Gly Tyr Thr Lys Ile Pro Tyr Asp Leu Asn Ala 
        355                 360                 365             
Gly Ala Lys Gly Asp Phe Ile Tyr Leu Cys Tyr His Glu Gln Ala Trp 
    370                 375                 380                 
Tyr Pro Asp Asn Thr Lys Pro Ala Val Thr Ala Ile Lys Ile Ile Tyr 
385                 390                 395                 400 
Asp Arg Glu Pro Val Pro Thr Gly Tyr Ile Lys Leu Pro Gln Asp Leu 
                405                 410                 415     
Asn Lys Gly Ala Gly Gly Asp Asp Val Phe Leu Cys Tyr Lys Thr Glu 
            420                 425                 430         
Ala Tyr Asn Thr Asp Thr Ala Ile Asn Lys Val Thr Val Ile Ser Gly 
        435                 440                 445             
Asn Asn Pro Asp Ile Asn Ala Pro Tyr Gly Tyr Glu Lys Val Pro Gly 
    450                 455                 460                 
Asp Leu Asn Lys Gly Ala Lys Gly Asn Phe Ile Tyr Ala Cys Thr Phe 
465                 470                 475                 480 
Val Gly Lys 
            

<210>  166
<211>  483
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  166
Met Glu Asn Ile Asp Leu Pro Gln Gly Leu Val Asn Phe Ser Thr Gln 
1               5                   10                  15      
His Leu Gln Leu Ile Arg Phe Lys Ala Gly Leu Asn Glu Thr Val Leu 
            20                  25                  30          
Pro Gly Val Glu Ala Ile Gly Leu Gly Tyr Asn Pro Phe Ile Ser Tyr 
        35                  40                  45              
Ala Ser Val Asn Ser Gly Ala Val Gln Leu Phe Asp Trp Ala Thr Ala 
    50                  55                  60                  
Lys Lys Arg Glu Val Pro Phe Lys Ala Gly Tyr Phe Val Pro Glu Ile 
65                  70                  75                  80  
Val Asp Val Gln Gln Asn Asp Ser Ala Thr Tyr Thr Asn Val Ser Gly 
                85                  90                  95      
Asn Thr Ile Ser Glu Tyr Gln Arg Ser Leu Ala Thr Ser Val Ala Ile 
            100                 105                 110         
Glu Gly Arg Tyr Asn Phe Phe Ser Gly Ser Leu Ser Thr Asp Tyr Asp 
        115                 120                 125             
Glu Asn Ser Leu Arg Asn Ala Glu Asn Glu Phe Thr Arg Ile Gln Gln 
    130                 135                 140                 
Ser Ile Asn Leu Trp Ser Leu Arg Leu Pro Ser Val Lys Ser Leu Arg 
145                 150                 155                 160 
Asp Leu Met Leu Pro His Met Arg Glu Gln Leu Asp Glu Leu Asp Val 
                165                 170                 175     
Lys Asn Pro Ser Ala Ile Ser Arg Phe Phe Asp Arg Val Gly Ser His 
            180                 185                 190         
Phe Leu Thr Gly Ile Val Met Gly Gly Arg Ala Ile Leu Ala Ala Ser 
        195                 200                 205             
Thr Asn Lys Leu Lys Val Lys Arg Asp Tyr Ser Val Ser Val Val Ala 
    210                 215                 220                 
Lys Ala Ser Tyr Glu Gly Leu Thr Gly Gln Leu Ser Ala Glu Ala Lys 
225                 230                 235                 240 
Ala Lys Tyr Gly Glu Ser Ile Ser Ser Phe Thr Gln Tyr Ser Asn Thr 
                245                 250                 255     
His Gln Glu Val Arg Gly Gly Asp Gly Ala Lys Ala His Gly Val Phe 
            260                 265                 270         
Ser Gly Lys Lys Glu Asp Phe Gln Ala Trp Val Asp Ser Val Ser Ala 
        275                 280                 285             
Ser Pro Asp Phe Val Asp Phe Val Pro Thr Ile Pro Met Gln Glu Ile 
    290                 295                 300                 
Trp Ser Leu Cys Lys Thr Asp Ser Gln Ala Glu Ala Met Lys Arg His 
305                 310                 315                 320 
Phe Asp Thr Val Trp Ala Arg Glu Gln Ser Asp Lys Tyr Arg Ile Lys 
                325                 330                 335     
Ala Asn Tyr Ile Asp Gln Leu Val Val Ile Thr Gly Asp Ser Ser Thr 
            340                 345                 350         
Ile Glu Pro Pro Ala Gly Tyr Thr Lys Ile Pro Tyr Asp Leu Asn Ala 
        355                 360                 365             
Gly Ala Gly Gly Asp Phe Ile Tyr Leu Cys Tyr His Glu Gln Thr Trp 
    370                 375                 380                 
Gln Ala Asp Arg Pro Lys Asp Ala Val Thr Asp Ile Arg Ile Ile Phe 
385                 390                 395                 400 
Asn Lys Glu Pro Thr Pro Pro Gly Tyr Thr Lys Leu Pro Gln Asp Leu 
                405                 410                 415     
Asn Lys Gly Ala Gly Gly Asp Asp Val Phe Leu Cys Tyr Lys Thr Glu 
            420                 425                 430         
Ala Tyr Asn Thr Asp Thr Ala Ile Asn Lys Val Thr Val Ile Gly Gly 
        435                 440                 445             
Asn Asn Ala Asp Ile Asn Ala Pro Tyr Gly Tyr Leu Lys Val Pro Gly 
    450                 455                 460                 
Asp Leu Asn Arg Gly Ala Gly Gly Asn Phe Ile Tyr Ala Cys Thr Phe 
465                 470                 475                 480 
Val Gly Lys 
            

<210>  167
<211>  483
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  167
Met Glu Asn Ile Asp Leu Pro Gln Gly Leu Val Asn Phe Ser Thr Gln 
1               5                   10                  15      
His Leu Gln Leu Ile Arg Phe Lys Ala Gly Leu Asn Glu Thr Val Leu 
            20                  25                  30          
Pro Gly Val Glu Ala Ile Gly Leu Gly Tyr Asn Pro Phe Ile Ser Tyr 
        35                  40                  45              
Ala Gly Val Gly Ser Gly Thr Val Gln Leu Phe Asp Trp Ala Thr Ala 
    50                  55                  60                  
Lys Lys Arg Glu Val Pro Phe Lys Ala Gly Tyr Phe Val Pro Glu Ile 
65                  70                  75                  80  
Val Asp Val Gln Gln Asn Asp Ser Ala Thr Tyr Thr Asn Val Ser Gly 
                85                  90                  95      
Asn Thr Ile Thr Glu Tyr Gln Arg Ser Leu Ala Thr Ser Val Ala Ile 
            100                 105                 110         
Glu Gly Arg Tyr Asn Phe Phe Ser Gly Ser Leu Ser Thr Asp Phe Asp 
        115                 120                 125             
Ser Asn Ser Leu Arg Asn Ala Glu Asn Glu Phe Ala Arg Ile Gln Gln 
    130                 135                 140                 
Ser Ile Asn Leu Trp Ser Leu Arg Leu Pro Ser Val Lys Ser Leu Arg 
145                 150                 155                 160 
Glu Leu Met Leu Pro His Met Arg Glu Gln Leu Asp Glu Leu Asp Val 
                165                 170                 175     
Lys Asn Pro Ser Ala Ile Ser Arg Phe Phe Asp Arg Val Gly Ser His 
            180                 185                 190         
Phe Leu Thr Gly Ile Val Met Gly Gly Arg Ala Ile Leu Ala Ser Ser 
        195                 200                 205             
Thr Asn Lys Leu Arg Val Lys Arg Asp Tyr Ser Val Ser Val Val Ala 
    210                 215                 220                 
Lys Ala Ser Tyr Glu Gly Leu Thr Gly Gln Leu Ser Ala Glu Ala Arg 
225                 230                 235                 240 
Thr Lys Tyr Gly Glu Ser Met Ser Ser Phe Thr Gln Tyr Ser Asn Thr 
                245                 250                 255     
His Gln Glu Val Arg Gly Gly Asp Gly Ala Lys Ala His Gly Val Phe 
            260                 265                 270         
Ser Gly Lys Lys Glu Asp Phe Gln Ala Trp Val Asp Ser Val Ser Ala 
        275                 280                 285             
Ser Pro Asp Phe Val Asp Phe Val Pro Thr Ile Pro Met Gln Glu Ile 
    290                 295                 300                 
Trp Thr Leu Cys Ser Ser Glu Ala Gln Ala Glu Ala Met Arg Lys His 
305                 310                 315                 320 
Tyr Asp Asp Val Trp Ala Pro Ala Gln Ser Glu Lys Tyr Arg Val Lys 
                325                 330                 335     
Ala Asn Tyr Ile Asp Gln Leu Val Val Ile Thr Gly Asp Ser Ser Thr 
            340                 345                 350         
Ile Glu Pro Pro Ala Gly Tyr Thr Lys Ile Pro Tyr Asp Leu Asn Ala 
        355                 360                 365             
Gly Ala Lys Gly Asp Phe Ile Tyr Leu Cys Tyr His Glu Gln Ala Trp 
    370                 375                 380                 
Tyr Pro Asp Asn Thr Lys Pro Ala Val Thr Ala Ile Lys Ile Ile Tyr 
385                 390                 395                 400 
Asp Arg Glu Pro Val Pro Thr Gly Tyr Ile Lys Leu Pro Gln Asp Leu 
                405                 410                 415     
Asn Lys Gly Ala Gly Gly Ala Asp Ile Tyr Leu Cys Tyr Lys Leu Glu 
            420                 425                 430         
Gly Tyr Asn Thr Asp Thr Ala Ile Asn Lys Val Thr Val Ile Gly Gly 
        435                 440                 445             
Asn Asn Ala Asp Ile Asn Ala Pro Tyr Gly Tyr Leu Lys Val Pro Gly 
    450                 455                 460                 
Asp Leu Asn Arg Gly Ala Gly Gly Asn Phe Ile Tyr Ala Cys Thr Phe 
465                 470                 475                 480 
Val Gly Lys 
            

<210>  168
<211>  482
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  168
Met Glu Asn Ile Asp Leu Pro Gln Gly Leu Val Asn Phe Ser Thr Gln 
1               5                   10                  15      
His Leu Gln Leu Ile Arg Phe Lys Ala Gly Leu Asn Glu Thr Val Leu 
            20                  25                  30          
Pro Gly Val Glu Ala Ile Gly Leu Gly Tyr Asn Pro Phe Ile Ser Tyr 
        35                  40                  45              
Ala Ser Val Asn Ser Gly Ala Val Gln Leu Phe Asp Trp Ala Thr Ala 
    50                  55                  60                  
Lys Lys Arg Glu Val Pro Phe Lys Ala Gly Tyr Phe Val Pro Glu Ile 
65                  70                  75                  80  
Val Asp Val Gln Gln Asn Asp Ser Ala Thr Tyr Thr Asn Val Ser Gly 
                85                  90                  95      
Asn Thr Ile Ser Glu Tyr Gln Arg Ser Leu Ala Thr Ser Val Ala Ile 
            100                 105                 110         
Glu Gly Arg Tyr Asn Phe Phe Ser Gly Ser Leu Ser Thr Asp Phe Asp 
        115                 120                 125             
Ser Asn Ser Leu Arg Asn Ala Glu Asn Glu Phe Thr Arg Ile Gln Gln 
    130                 135                 140                 
Ser Ile Asn Leu Trp Ser Leu Arg Leu Pro Ser Val Lys Ser Leu Arg 
145                 150                 155                 160 
Glu Leu Met Leu Pro His Met Arg Gln Gln Leu Asp Glu Leu Asn Val 
                165                 170                 175     
Asn Asp Pro Lys Ala Ile Ser Arg Tyr Phe Asp Arg Val Gly Ser His 
            180                 185                 190         
Phe Leu Thr Gly Ile Val Met Gly Gly Arg Ala Ile Leu Ala Ser Ser 
        195                 200                 205             
Thr Asn Lys Leu Arg Val Lys Arg Asp Tyr Ser Val Ser Val Ile Ala 
    210                 215                 220                 
Lys Ala Ser Tyr Glu Gly Leu Thr Gly Gln Leu Ser Ala Glu Ala Arg 
225                 230                 235                 240 
Thr Lys Tyr Gly Glu Ser Met Ser Ser Phe Thr Gln Tyr Ser Ser Thr 
                245                 250                 255     
His Gln Glu Val Arg Gly Gly Asp Gly Thr Lys Ala His Gly Val Phe 
            260                 265                 270         
Glu Gly Lys Ala Gly Phe Gln Ala Trp Val Asp Ser Val Ser Ala Ser 
        275                 280                 285             
Pro Asp Phe Val Asp Phe Val Pro Thr Ile Pro Met Gln Glu Ile Trp 
    290                 295                 300                 
Thr Leu Cys Ser Ser Glu Ala Gln Ala Glu Ala Met Arg Lys His Tyr 
305                 310                 315                 320 
Asp Asp Val Trp Ala Pro Ala Gln Ser Glu Lys Tyr Arg Val Lys Ala 
                325                 330                 335     
Asn Tyr Ile Asp Gln Leu Val Val Ile Thr Gly Asp Ser Ser Thr Ile 
            340                 345                 350         
Glu Pro Pro Ala Gly Tyr Thr Lys Ile Pro Tyr Asp Leu Asn Ala Gly 
        355                 360                 365             
Ala Lys Gly Asp Phe Ile Tyr Leu Cys Tyr His Glu Gln Ala Trp Tyr 
    370                 375                 380                 
Pro Asp Asn Thr Lys Pro Ala Val Thr Ala Ile Lys Ile Ile Tyr Asp 
385                 390                 395                 400 
Arg Glu Pro Val Pro Thr Gly Tyr Ile Lys Leu Pro Gln Asp Leu Asn 
                405                 410                 415     
Lys Gly Ala Gly Gly Asp Asp Val Phe Leu Cys Tyr Lys Thr Glu Ala 
            420                 425                 430         
Tyr Asn Thr Asp Thr Ala Ile Asn Lys Val Thr Val Ile Gly Gly Asn 
        435                 440                 445             
Asn Ala Asp Ile Asn Ala Pro Tyr Gly Tyr Leu Lys Val Pro Gly Asp 
    450                 455                 460                 
Leu Asn Arg Gly Ala Gly Gly Asn Phe Ile Tyr Ala Cys Thr Phe Val 
465                 470                 475                 480 
Gly Lys 
        

<210>  169
<211>  483
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  169
Met Glu His Val Asp Leu Pro Thr Gly Leu Val Lys Phe Ser Ser Asn 
1               5                   10                  15      
His His Leu Gln Leu Leu Arg Asp Thr Ala Asp Leu Ser Glu Ser Val 
            20                  25                  30          
Leu Pro Gly Val Glu Ala Ile Gly Leu Gly Tyr Asn Pro Phe Ile Ser 
        35                  40                  45              
Tyr Ala Ser Val Asn Ser Gly Ala Val Gln Leu Phe Asp Trp Ala Thr 
    50                  55                  60                  
Ala Lys Lys Arg Glu Val Pro Phe Lys Ala Gly Tyr Phe Val Pro Glu 
65                  70                  75                  80  
Ile Val Asp Val Gln Gln Asn Asp Ser Ala Ser Tyr Thr Asn Ile Ser 
                85                  90                  95      
Gly Asn Thr Ile Ser Glu Tyr Gln Arg Ser Leu Ala Thr Ser Val Ala 
            100                 105                 110         
Ile Glu Gly Arg Tyr Asn Phe Phe Ser Gly Ser Leu Ser Thr Asp Phe 
        115                 120                 125             
Asp Ser Asn Ser Leu Arg Asn Ala Glu Asn Glu Phe Thr Arg Ile Gln 
    130                 135                 140                 
Gln Ser Ile Asn Leu Trp Ser Leu Arg Leu Pro Ser Val Lys Ser Leu 
145                 150                 155                 160 
Arg Glu Leu Met Leu Pro His Met Arg Gln Gln Leu Asp Glu Leu Asn 
                165                 170                 175     
Val Asn Asp Pro Lys Ala Ile Ser Arg Tyr Phe Asp Arg Val Gly Ser 
            180                 185                 190         
His Phe Leu Thr Gly Ile Val Met Gly Gly Arg Ala Ile Leu Ala Ser 
        195                 200                 205             
Ser Thr Asn Lys Leu Lys Val Lys Arg Asp Tyr Ser Val Ser Val Val 
    210                 215                 220                 
Ala Lys Ala Ser Tyr Glu Gly Leu Thr Gly Gln Leu Ser Ala Glu Ala 
225                 230                 235                 240 
Arg Thr Lys Tyr Gly Glu Ser Ile Ser Ser Phe Thr Gln Tyr Ser Ser 
                245                 250                 255     
Thr His Gln Glu Val Arg Gly Gly Asp Gly Thr Lys Ala His Gly Val 
            260                 265                 270         
Phe Glu Gly Lys Ala Gly Phe Gln Ala Trp Val Asp Ser Val Gly Thr 
        275                 280                 285             
Ser Pro Asp Phe Val Asp Phe Val Pro Thr Ile Pro Met Leu Glu Ile 
    290                 295                 300                 
Trp Ser Leu Cys Lys Thr Asp Ser Gln Ala Glu Ala Met Lys Arg His 
305                 310                 315                 320 
Phe Asp Thr Val Trp Ala Arg Glu Gln Ser Asp Lys Tyr Arg Ile Lys 
                325                 330                 335     
Ala Asn Tyr Ile Asp Gln Leu Val Val Ile Thr Gly Asp Ser Ser Thr 
            340                 345                 350         
Ile Glu Pro Pro Ala Gly Tyr Thr Lys Ile Pro Tyr Asp Leu Asn Ala 
        355                 360                 365             
Gly Ala Lys Gly Asp Phe Ile Tyr Leu Cys Tyr His Glu Gln Ala Trp 
    370                 375                 380                 
Tyr Pro Asp Asn Thr Lys Pro Ala Val Thr Ala Ile Lys Ile Ile Tyr 
385                 390                 395                 400 
Asp Arg Glu Ser Val Pro Thr Gly Tyr Ile Lys Leu Pro Gln Asp Leu 
                405                 410                 415     
Asn Lys Gly Ala Gly Gly Ala Asp Ile Tyr Leu Cys Tyr Lys Leu Glu 
            420                 425                 430         
Gly Tyr Asn Thr Asp Thr Ala Ile Asn Lys Ile Thr Val Ile Ser Gly 
        435                 440                 445             
Asn Asn Pro Asp Ile Asn Ala Pro Tyr Gly Tyr Leu Lys Val Pro Gly 
    450                 455                 460                 
Asp Leu Asn Arg Gly Ala Gly Gly Asn Phe Ile Tyr Ala Cys Thr Phe 
465                 470                 475                 480 
Val Gly Lys 
            

<210>  170
<211>  483
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  170
Met Glu His Val Asp Leu Pro Thr Gly Leu Val Lys Phe Ser Ser Asn 
1               5                   10                  15      
His His Leu Gln Leu Leu Arg Asp Thr Ala Asp Leu Ser Glu Ser Val 
            20                  25                  30          
Leu Pro Gly Val Glu Ala Ile Gly Leu Gly Tyr Asn Pro Phe Leu Gly 
        35                  40                  45              
Tyr Ala Gly Val Gly Ser Gly Thr Val Gln Leu Phe Asp Trp Asn Asn 
    50                  55                  60                  
Ala Lys Lys Lys Lys Val Ser Phe Lys Pro Glu Phe Val Val Pro Glu 
65                  70                  75                  80  
Ile Val Asp Val Gln Gln Asn Asp Ser Ala Ser Tyr Thr Asn Ile Ser 
                85                  90                  95      
Gly Asn Thr Ile Ser Glu Tyr Gln Arg Ser Leu Ala Thr Ser Val Ala 
            100                 105                 110         
Ile Glu Gly Arg Tyr Asn Phe Phe Ser Gly Ser Leu Ser Thr Asp Phe 
        115                 120                 125             
Asp Ser Asn Ser Leu Arg Asn Ala Glu Asn Glu Phe Thr Arg Ile Gln 
    130                 135                 140                 
Gln Ser Ile Asn Leu Trp Ser Leu Arg Leu Pro Ser Val Lys Ser Leu 
145                 150                 155                 160 
Arg Glu Leu Met Leu Pro His Met Arg Gln Gln Leu Asp Glu Leu Asn 
                165                 170                 175     
Val Asn Asp Pro Lys Ala Ile Ser Arg Tyr Phe Asp Arg Val Gly Ser 
            180                 185                 190         
His Phe Leu Thr Gly Ile Val Met Gly Gly Arg Ala Ile Leu Ala Ala 
        195                 200                 205             
Ser Thr Asn Lys Leu Lys Val Lys Arg Asp Tyr Ser Val Ser Val Ile 
    210                 215                 220                 
Ala Lys Ala Ser Tyr Glu Gly Leu Thr Gly Gln Leu Ser Ala Glu Ala 
225                 230                 235                 240 
Lys Ala Lys Tyr Gly Glu Ser Ile Ser Ser Phe Thr Gln Tyr Ser Ser 
                245                 250                 255     
Thr His Gln Glu Val Arg Gly Gly Asp Gly Thr Lys Ala His Gly Val 
            260                 265                 270         
Phe Glu Gly Lys Ala Gly Phe Gln Ala Trp Val Asp Ser Val Gly Thr 
        275                 280                 285             
Ser Pro Asp Phe Val Asp Phe Val Pro Thr Ile Pro Met Leu Glu Ile 
    290                 295                 300                 
Trp Ser Leu Cys Lys Thr Asp Ser Gln Ala Glu Ala Met Lys Arg His 
305                 310                 315                 320 
Phe Asp Thr Val Trp Ala Arg Glu Gln Ser Asp Lys Tyr Arg Ile Lys 
                325                 330                 335     
Ala Asn Tyr Ile Asp Gln Leu Val Val Ile Thr Gly Gly Ser Ser Thr 
            340                 345                 350         
Ile Glu Pro Pro Val Gly Tyr Thr Lys Ile Pro Tyr Asp Leu Asn Ala 
        355                 360                 365             
Gly Ala Gly Gly Asp Phe Ile Tyr Leu Cys Tyr His Glu Gln Thr Trp 
    370                 375                 380                 
Gln Ala Asp Arg Pro Lys Asp Ala Val Thr Asp Ile Arg Ile Ile Phe 
385                 390                 395                 400 
Asn Lys Glu Pro Thr Pro Pro Gly Tyr Thr Lys Leu Pro Gln Asp Leu 
                405                 410                 415     
Asn Lys Gly Ala Gly Gly Ala Asp Ile Tyr Leu Cys Tyr Lys Leu Glu 
            420                 425                 430         
Gly Tyr Asn Thr Asp Thr Ala Ile Asn Lys Ile Thr Val Ile Ser Gly 
        435                 440                 445             
Asn Asn Pro Asp Ile Asn Ala Pro Tyr Gly Tyr Glu Lys Val Pro Gly 
    450                 455                 460                 
Asp Leu Asn Lys Gly Ala Lys Gly Asn Phe Ile Tyr Ala Cys Thr Phe 
465                 470                 475                 480 
Val Gly Lys 
            

<210>  171
<211>  484
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  171
Met Glu His Val Asp Leu Pro Thr Gly Leu Val Lys Phe Ser Ser Asn 
1               5                   10                  15      
His His Leu Gln Leu Leu Arg Asp Thr Ala Asp Leu Ser Glu Ser Val 
            20                  25                  30          
Leu Pro Gly Val Glu Ala Ile Gly Leu Gly Tyr Asn Pro Phe Leu Gly 
        35                  40                  45              
Tyr Ala Ser Val Asn Ser Gly Ala Val Gln Leu Phe Asp Trp Ala Thr 
    50                  55                  60                  
Ala Lys Lys Arg Glu Val Pro Phe Lys Ala Gly Tyr Phe Val Pro Glu 
65                  70                  75                  80  
Ile Val Asp Val Gln Gln Asn Asp Ser Ala Thr Tyr Thr Asn Val Ser 
                85                  90                  95      
Gly Asn Thr Ile Ser Glu Tyr Gln Arg Ser Leu Ala Val Ser Val Ala 
            100                 105                 110         
Ile Glu Gly Lys Tyr Asn Phe Phe Ser Gly Ser Leu Ser Thr Asp Tyr 
        115                 120                 125             
Asp Glu Asn Ser Leu Arg Asn Ala Glu Asn Glu Phe Thr Arg Ile Gln 
    130                 135                 140                 
Gln Ser Ile Asn Leu Trp Ser Leu Arg Leu Pro Ser Val Lys Ser Leu 
145                 150                 155                 160 
Arg Asp Leu Met Leu Pro His Met Arg Glu Gln Leu Asp Glu Leu Asp 
                165                 170                 175     
Val Lys Asn Pro Ser Ala Ile Ser Arg Phe Phe Asp Arg Val Gly Ser 
            180                 185                 190         
His Phe Leu Thr Gly Ile Val Met Gly Gly Arg Ala Ile Leu Ala Ala 
        195                 200                 205             
Ser Thr Asn Lys Leu Lys Val Lys Arg Asp Tyr Ser Val Ser Val Ile 
    210                 215                 220                 
Ala Lys Ala Ser Tyr Glu Gly Leu Thr Asp Gln Leu Ser Ala Glu Ala 
225                 230                 235                 240 
Lys Ala Lys Tyr Gly Glu Ser Ile Ser Ser Phe Thr Gln Tyr Ser Asn 
                245                 250                 255     
Thr His Gln Glu Val Arg Gly Gly Asp Gly Ala Lys Ala His Gly Val 
            260                 265                 270         
Phe Ser Gly Lys Lys Glu Asp Phe Gln Ala Trp Val Asp Ser Val Ser 
        275                 280                 285             
Ala Ser Pro Asp Phe Val Asp Phe Val Pro Thr Ile Pro Met Gln Glu 
    290                 295                 300                 
Ile Trp Thr Leu Cys Ser Ser Glu Ala Gln Ala Glu Ala Met Arg Lys 
305                 310                 315                 320 
His Tyr Asp Asp Val Trp Ala Pro Ala Gln Ser Glu Lys Tyr Arg Val 
                325                 330                 335     
Lys Ala Asn Tyr Ile Asp Gln Leu Val Val Ile Thr Gly Asp Ser Ser 
            340                 345                 350         
Thr Ile Glu Pro Pro Val Gly Tyr Ser Lys Ile Glu Tyr Asp Leu Asn 
        355                 360                 365             
Ala Gly Ala Gly Gly Asp Phe Ile Tyr Leu Cys Tyr His Glu Gln Thr 
    370                 375                 380                 
Trp Gln Ala Asp Arg Pro Lys Asp Ala Val Thr Asp Ile Arg Ile Ile 
385                 390                 395                 400 
Tyr Asn Lys Glu Pro Thr Pro Pro Gly Tyr Thr Lys Leu Pro Gln Asp 
                405                 410                 415     
Leu Asn Lys Gly Ala Gly Gly Asp Asp Val Phe Leu Cys Tyr Lys Thr 
            420                 425                 430         
Glu Ala Tyr Asn Thr Asp Thr Ala Ile Asn Lys Val Thr Val Ile Gly 
        435                 440                 445             
Gly Asn Asn Pro Asp Ile Asn Ala Pro Tyr Gly Tyr Glu Lys Val Pro 
    450                 455                 460                 
Gly Asp Leu Asn Lys Gly Ala Gly Gly Asn Phe Ile Tyr Ala Cys Thr 
465                 470                 475                 480 
Phe Val Gly Lys 
                

<210>  172
<211>  483
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  172
Met Glu Asn Ile Asp Leu Pro Gln Gly Leu Val Asn Phe Ser Thr Gln 
1               5                   10                  15      
His Leu Gln Leu Ile Arg Phe Lys Ala Gly Leu Asn Glu Thr Val Leu 
            20                  25                  30          
Pro Gly Val Glu Ala Ile Gly Leu Gly Tyr Asn Pro Phe Ile Ser Tyr 
        35                  40                  45              
Ala Ser Val Asn Ser Gly Ala Val Gln Leu Phe Asp Trp Ala Thr Ala 
    50                  55                  60                  
Lys Lys Arg Glu Val Pro Phe Lys Ala Gly Tyr Phe Val Pro Glu Ile 
65                  70                  75                  80  
Val Asp Val Gln Gln Asn Asp Ser Ala Thr Tyr Thr Asn Val Ser Gly 
                85                  90                  95      
Asn Thr Ile Ser Glu Tyr Gln Arg Ser Leu Ala Thr Ser Val Ala Ile 
            100                 105                 110         
Glu Gly Arg Tyr Asn Phe Phe Ser Gly Ser Leu Ser Thr Asp Phe Asp 
        115                 120                 125             
Glu Asn Ser Leu Arg Asn Ala Glu Asn Glu Phe Thr Arg Ile Gln Gln 
    130                 135                 140                 
Ser Ile Asn Leu Trp Ser Leu Arg Leu Pro Ser Val Lys Ser Leu Arg 
145                 150                 155                 160 
Asp Leu Met Leu Pro His Met Arg Gln Gln Leu Asp Glu Leu Asn Val 
                165                 170                 175     
Asn Asp Pro Lys Ala Ile Ser Arg Tyr Phe Asp Arg Val Gly Ser His 
            180                 185                 190         
Phe Leu Thr Gly Ile Val Met Gly Gly Arg Ala Ile Leu Ala Ser Ser 
        195                 200                 205             
Thr Asn Lys Leu Arg Val Lys Arg Asp Tyr Ser Val Ser Val Ile Ala 
    210                 215                 220                 
Lys Ala Ser Tyr Glu Gly Leu Thr Gly Gln Leu Ser Ala Lys Ala Arg 
225                 230                 235                 240 
Thr Lys Tyr Gly Glu Ser Met Ser Ser Phe Thr Gln Tyr Ser Ser Thr 
                245                 250                 255     
His Gln Glu Val Arg Gly Gly Asp Gly Ala Lys Ala His Gly Val Phe 
            260                 265                 270         
Ser Gly Lys Lys Glu Asp Phe Gln Ala Trp Val Asp Ser Val Ser Ala 
        275                 280                 285             
Ser Pro Asp Phe Val Asp Phe Val Pro Thr Ile Pro Met Gln Glu Ile 
    290                 295                 300                 
Trp Thr Leu Cys Ser Ser Glu Ala Gln Ala Glu Ala Met Arg Lys His 
305                 310                 315                 320 
Tyr Asp Asp Val Trp Ala Pro Ala Gln Ser Glu Lys Tyr Arg Ile Lys 
                325                 330                 335     
Ala Asn Tyr Ile Asp Gln Leu Val Val Ile Thr Gly Asp Ser Ser Thr 
            340                 345                 350         
Ile Glu Pro Pro Ala Gly Tyr Thr Lys Ile Pro Tyr Asp Leu Asn Ala 
        355                 360                 365             
Gly Ala Lys Gly Asp Phe Ile Tyr Leu Cys Tyr His Glu Gln Ala Trp 
    370                 375                 380                 
Tyr Pro Asp Asn Thr Lys Pro Ala Val Thr Ala Ile Lys Ile Ile Tyr 
385                 390                 395                 400 
Asp Arg Glu Pro Val Pro Thr Gly Tyr Ile Lys Leu Pro Gln Asp Leu 
                405                 410                 415     
Asn Lys Gly Ala Gly Gly Asp Asp Val Phe Leu Cys Tyr Lys Thr Glu 
            420                 425                 430         
Ala Tyr Asn Thr Asp Thr Ala Ile Asn Lys Val Thr Val Ile Gly Gly 
        435                 440                 445             
Asn Asn Ala Asp Ile Asn Ala Pro Tyr Gly Tyr Leu Lys Val Pro Gly 
    450                 455                 460                 
Asp Leu Asn Arg Gly Ala Gly Gly Asn Phe Ile Tyr Ala Cys Thr Phe 
465                 470                 475                 480 
Val Gly Lys 
            

<210>  173
<211>  483
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  173
Met Glu His Val Asp Leu Pro Thr Gly Leu Val Lys Phe Ser Ser Asn 
1               5                   10                  15      
His His Leu Gln Leu Leu Arg Asp Thr Ala Asp Leu Ser Glu Ser Val 
            20                  25                  30          
Leu Pro Gly Val Glu Ala Ile Gly Leu Gly Tyr Asn Pro Phe Leu Gly 
        35                  40                  45              
Tyr Ala Ser Val Asn Ser Gly Ala Val Gln Leu Phe Asp Trp Ala Thr 
    50                  55                  60                  
Ala Lys Lys Arg Glu Val Pro Phe Lys Ala Gly Tyr Phe Val Pro Glu 
65                  70                  75                  80  
Ile Val Asp Val Gln Gln Asn Asp Ser Ala Thr Tyr Thr Asn Val Ser 
                85                  90                  95      
Gly Asn Thr Ile Ser Glu Tyr Gln Arg Ser Leu Ala Thr Ser Val Ala 
            100                 105                 110         
Ile Glu Gly Lys Tyr Asn Phe Phe Ser Gly Ser Leu Ser Thr Asp Tyr 
        115                 120                 125             
Asp Glu Asn Ser Leu Arg Asn Ala Glu Asn Glu Phe Thr Arg Ile Gln 
    130                 135                 140                 
Gln Ser Ile Asn Leu Trp Ser Leu Arg Leu Pro Ser Val Lys Ser Leu 
145                 150                 155                 160 
Arg Asp Leu Met Leu Pro His Met Arg Glu Gln Leu Asp Glu Leu Asp 
                165                 170                 175     
Val Lys Asn Pro Ser Ala Ile Ser Arg Tyr Phe Asp Arg Val Gly Ser 
            180                 185                 190         
His Phe Leu Thr Gly Ile Val Met Gly Gly Arg Ala Ile Leu Ala Ala 
        195                 200                 205             
Ser Thr Asn Lys Leu Lys Val Lys Arg Asp Tyr Ser Val Ser Val Ile 
    210                 215                 220                 
Ala Lys Ala Ser Tyr Glu Gly Leu Thr Gly Gln Leu Ser Ala Glu Ala 
225                 230                 235                 240 
Arg Thr Lys Tyr Gly Glu Ser Met Ser Ser Phe Thr Gln Tyr Ser Ser 
                245                 250                 255     
Thr His Gln Glu Val Arg Gly Gly Asp Gly Thr Lys Ala His Gly Val 
            260                 265                 270         
Phe Glu Gly Lys Ala Gly Phe Gln Ala Trp Val Asp Ser Val Gly Thr 
        275                 280                 285             
Ser Pro Asp Phe Val Asp Phe Val Pro Thr Ile Pro Met Gln Glu Ile 
    290                 295                 300                 
Trp Thr Leu Cys Ser Ser Glu Ala Gln Ala Glu Ala Met Arg Lys His 
305                 310                 315                 320 
Tyr Asp Asp Val Trp Ala Pro Ala Gln Ser Glu Lys Tyr Arg Val Lys 
                325                 330                 335     
Ala Asn Tyr Ile Asp Gln Leu Val Val Ile Thr Gly Gly Ser Ser Thr 
            340                 345                 350         
Ile Glu Pro Pro Val Gly Tyr Thr Lys Ile Pro Tyr Asp Leu Asn Ala 
        355                 360                 365             
Gly Ala Gly Gly Asp Phe Ile Tyr Leu Cys Tyr His Glu Gln Thr Trp 
    370                 375                 380                 
Gln Ala Asp Arg Pro Lys Asp Ala Val Thr Asp Ile Arg Ile Ile Phe 
385                 390                 395                 400 
Asn Lys Glu Pro Thr Pro Pro Gly Tyr Thr Lys Leu Pro Gln Asp Leu 
                405                 410                 415     
Asn Lys Gly Ala Gly Gly Asp Asp Ile Tyr Leu Cys Tyr Lys Leu Glu 
            420                 425                 430         
Gly Tyr Asn Thr Asp Thr Ala Ile Asn Lys Ile Thr Val Ile Ser Gly 
        435                 440                 445             
Asn Asn Pro Asp Ile Asn Ala Pro Tyr Gly Tyr Leu Lys Val Pro Gly 
    450                 455                 460                 
Asp Leu Asn Arg Gly Ala Gly Gly Asn Phe Ile Tyr Ala Cys Thr Phe 
465                 470                 475                 480 
Val Gly Lys 
            

<210>  174
<211>  482
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  174
Met Glu Asn Ile Asp Leu Pro Gln Gly Leu Val Asn Phe Ser Thr Gln 
1               5                   10                  15      
His Leu Gln Leu Ile Arg Phe Lys Ala Gly Leu Asn Glu Thr Val Leu 
            20                  25                  30          
Pro Gly Val Glu Ala Ile Gly Leu Gly Tyr Asn Pro Phe Ile Ser Tyr 
        35                  40                  45              
Ala Ser Val Asn Ser Gly Ala Val Gln Leu Phe Asp Trp Ala Thr Ala 
    50                  55                  60                  
Lys Lys Arg Glu Val Pro Phe Lys Pro Glu Phe Val Val Pro Glu Ile 
65                  70                  75                  80  
Val Asp Val Gln Gln Asn Asp Ser Ala Thr Tyr Thr Asn Val Ser Gly 
                85                  90                  95      
Asn Thr Ile Ser Glu Tyr Gln Arg Ser Leu Ala Thr Ser Val Ala Ile 
            100                 105                 110         
Glu Gly Arg Tyr Asn Phe Phe Ser Gly Ser Leu Ser Thr Asp Tyr Asp 
        115                 120                 125             
Glu Asn Ser Leu Arg Asn Ala Glu Asn Glu Phe Thr Arg Ile Gln Gln 
    130                 135                 140                 
Ser Ile Asn Leu Trp Ser Leu Arg Leu Pro Ser Val Lys Ser Leu Arg 
145                 150                 155                 160 
Asp Leu Met Leu Pro His Met Arg Glu Gln Leu Asp Glu Leu Asp Val 
                165                 170                 175     
Lys Asn Pro Ser Ala Ile Ser Arg Phe Phe Asp Arg Val Gly Ser His 
            180                 185                 190         
Phe Leu Thr Gly Ile Val Met Gly Gly Arg Ala Ile Leu Ala Ala Ser 
        195                 200                 205             
Thr Asn Lys Leu Lys Val Lys Arg Asp Tyr Ser Val Ser Val Ile Ala 
    210                 215                 220                 
Lys Ala Ser Tyr Glu Gly Leu Thr Gly Gln Leu Ser Ala Glu Ala Arg 
225                 230                 235                 240 
Thr Lys Tyr Gly Glu Ser Met Ser Ser Phe Thr Gln Tyr Ser Ser Thr 
                245                 250                 255     
His Gln Glu Val Arg Gly Gly Asp Gly Thr Lys Ala His Gly Val Phe 
            260                 265                 270         
Glu Gly Lys Ala Gly Phe Gln Ala Trp Val Asp Ser Val Ser Ala Ser 
        275                 280                 285             
Pro Asp Phe Val Asp Phe Val Pro Thr Ile Pro Met Gln Glu Ile Trp 
    290                 295                 300                 
Thr Leu Cys Ser Ser Glu Ala Gln Ala Glu Ala Met Arg Lys His Tyr 
305                 310                 315                 320 
Asp Asp Val Trp Ala Pro Ala Gln Ser Glu Lys Tyr Arg Val Lys Ala 
                325                 330                 335     
Asn Tyr Ile Asp Gln Leu Val Val Ile Thr Gly Asp Ser Ser Thr Ile 
            340                 345                 350         
Glu Pro Pro Val Gly Tyr Ser Lys Ile Glu Tyr Asp Leu Asn Ala Gly 
        355                 360                 365             
Ala Gly Gly Asp Phe Ile Tyr Leu Cys Tyr His Glu Gln Thr Trp Gln 
    370                 375                 380                 
Ala Asp Arg Pro Lys Asp Ala Val Thr Asp Ile Arg Ile Ile Phe Asn 
385                 390                 395                 400 
Lys Glu Pro Thr Pro Thr Gly Tyr Ile Lys Leu Pro Gln Asp Leu Asn 
                405                 410                 415     
Lys Gly Ala Gly Gly Ala Asp Ile Tyr Leu Cys Tyr Lys Leu Glu Gly 
            420                 425                 430         
Tyr Asn Thr Asp Thr Ala Ile Asn Lys Ile Thr Val Ile Ser Gly Asn 
        435                 440                 445             
Asn Pro Asp Ile Asn Ala Pro Tyr Gly Tyr Glu Lys Val Pro Gly Asp 
    450                 455                 460                 
Leu Asn Arg Gly Ala Gly Gly Asn Phe Ile Tyr Ala Cys Thr Phe Val 
465                 470                 475                 480 
Gly Lys 
        

<210>  175
<211>  482
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  175
Met Glu Asn Ile Asp Leu Pro Gln Gly Leu Val Asn Phe Ser Thr Gln 
1               5                   10                  15      
His Leu Gln Leu Ile Arg Phe Lys Ala Gly Leu Asn Glu Thr Val Leu 
            20                  25                  30          
Pro Gly Val Glu Ala Ile Gly Leu Gly Tyr Asn Pro Phe Ile Ser Tyr 
        35                  40                  45              
Ala Ser Val Asn Ser Gly Ala Val Gln Leu Phe Asp Trp Ala Thr Ala 
    50                  55                  60                  
Lys Lys Arg Glu Val Pro Phe Lys Ala Gly Tyr Phe Val Pro Glu Ile 
65                  70                  75                  80  
Val Asp Val Gln Gln Asn Asp Ser Ala Thr Tyr Thr Asn Val Ser Gly 
                85                  90                  95      
Asn Thr Ile Ser Glu Tyr Gln Arg Ser Leu Ala Thr Ser Val Ala Ile 
            100                 105                 110         
Glu Gly Arg Tyr Asn Phe Phe Ser Gly Ser Leu Ser Thr Asp Phe Asp 
        115                 120                 125             
Ser Asn Ser Leu Arg Asn Ala Glu Asn Glu Phe Thr Arg Ile Gln Gln 
    130                 135                 140                 
Ser Ile Asn Leu Trp Ser Leu Arg Leu Pro Ser Val Lys Ser Leu Arg 
145                 150                 155                 160 
Asp Leu Met Leu Pro His Met Arg Glu Gln Leu Asp Glu Leu Asp Val 
                165                 170                 175     
Asn Asp Pro Lys Ala Ile Ser Arg Tyr Phe Asp Arg Val Gly Ser His 
            180                 185                 190         
Phe Leu Thr Gly Ile Val Met Gly Gly Arg Ala Ile Leu Ala Ser Ser 
        195                 200                 205             
Thr Asn Lys Leu Arg Val Lys Arg Asp Tyr Ser Val Ser Val Val Ala 
    210                 215                 220                 
Lys Ala Ser Tyr Glu Gly Leu Thr Gly Gln Leu Ser Ala Glu Ala Arg 
225                 230                 235                 240 
Thr Lys Tyr Gly Glu Ser Met Ser Ser Phe Thr Gln Tyr Ser Ser Thr 
                245                 250                 255     
His Gln Glu Val Arg Gly Gly Asp Gly Thr Lys Ala His Gly Val Phe 
            260                 265                 270         
Glu Gly Lys Ala Gly Phe Gln Ala Trp Val Asp Ser Val Gly Thr Ser 
        275                 280                 285             
Pro Asp Phe Val Asp Phe Val Pro Thr Ile Pro Met Leu Glu Ile Trp 
    290                 295                 300                 
Ser Leu Cys Lys Thr Asp Ser Gln Ala Glu Ala Met Lys Arg His Phe 
305                 310                 315                 320 
Asp Thr Val Trp Ala Arg Glu Gln Ser Asp Lys Tyr Arg Ile Lys Ala 
                325                 330                 335     
Asn Tyr Ile Asp Gln Leu Val Val Ile Thr Gly Asp Ser Ser Thr Ile 
            340                 345                 350         
Glu Pro Pro Ala Gly Tyr Thr Lys Ile Pro Tyr Asp Leu Asn Ala Gly 
        355                 360                 365             
Ala Lys Gly Asp Phe Ile Tyr Leu Cys Tyr His Glu Gln Ala Trp Tyr 
    370                 375                 380                 
Pro Asp Asn Thr Lys Pro Ala Val Thr Ala Ile Lys Ile Ile Tyr Asp 
385                 390                 395                 400 
Arg Glu Pro Val Pro Thr Gly Tyr Ile Lys Leu Pro Gln Asp Leu Asn 
                405                 410                 415     
Lys Gly Ala Gly Gly Asp Asp Val Phe Leu Cys Tyr Lys Thr Glu Ala 
            420                 425                 430         
Tyr Asn Thr Asp Thr Ala Ile Asn Lys Val Thr Val Ile Gly Gly Asn 
        435                 440                 445             
Asn Ala Asp Ile Asn Ala Pro Tyr Gly Tyr Leu Lys Val Pro Gly Asp 
    450                 455                 460                 
Leu Asn Arg Gly Ala Gly Gly Asn Phe Ile Tyr Ala Cys Thr Phe Val 
465                 470                 475                 480 
Gly Lys 
        

<210>  176
<211>  483
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  176
Met Glu Asn Ile Asp Leu Pro Gln Gly Leu Val Asn Phe Ser Thr Gln 
1               5                   10                  15      
His Leu Gln Leu Ile Arg Phe Lys Ala Gly Leu Asn Glu Thr Val Leu 
            20                  25                  30          
Pro Gly Val Glu Ala Ile Gly Leu Gly Tyr Asn Pro Phe Ile Ser Tyr 
        35                  40                  45              
Ala Ser Val Asn Ser Gly Ala Val Gln Leu Phe Asp Trp Ala Thr Ala 
    50                  55                  60                  
Lys Lys Arg Glu Val Pro Phe Lys Ala Gly Tyr Phe Val Pro Glu Ile 
65                  70                  75                  80  
Val Asp Val Gln Gln Asn Asp Ser Ala Thr Tyr Thr Asn Val Ser Gly 
                85                  90                  95      
Asn Thr Ile Ser Glu Tyr Gln Arg Ser Leu Ala Thr Ser Val Ala Ile 
            100                 105                 110         
Glu Gly Arg Tyr Asn Phe Phe Ser Gly Ser Leu Ser Thr Asp Phe Asp 
        115                 120                 125             
Ser Asn Ser Leu Arg Asn Ala Glu Asn Glu Phe Thr Arg Ile Gln Gln 
    130                 135                 140                 
Ser Ile Asn Leu Trp Ser Leu Arg Leu Pro Ser Val Lys Ser Leu Arg 
145                 150                 155                 160 
Glu Leu Met Leu Pro His Met Arg Gln Gln Leu Asp Glu Leu Asn Val 
                165                 170                 175     
Asn Asp Pro Lys Ala Ile Ser Arg Tyr Phe Asp Arg Val Gly Ser His 
            180                 185                 190         
Phe Leu Thr Gly Ile Val Met Gly Gly Arg Ala Ile Leu Ala Ala Ser 
        195                 200                 205             
Thr Asn Lys Leu Lys Val Lys Arg Asp Tyr Ser Val Ser Val Ile Ala 
    210                 215                 220                 
Lys Ala Ser Tyr Glu Gly Leu Thr Gly Gln Leu Ser Ala Glu Ala Lys 
225                 230                 235                 240 
Ala Lys Tyr Gly Glu Ser Ile Ser Ser Phe Thr Gln Tyr Ser Asn Thr 
                245                 250                 255     
His Gln Glu Val Arg Gly Gly Asp Gly Ala Lys Ala His Gly Val Phe 
            260                 265                 270         
Ser Gly Lys Lys Glu Asp Phe Gln Ala Trp Val Asp Ser Val Ser Ala 
        275                 280                 285             
Ser Pro Asp Phe Val Asp Phe Val Pro Thr Ile Pro Met Gln Glu Ile 
    290                 295                 300                 
Trp Thr Leu Cys Ser Ser Glu Ala Gln Ala Glu Ala Met Arg Lys His 
305                 310                 315                 320 
Tyr Asp Asp Val Trp Ala Pro Ala Gln Ser Glu Lys Tyr Arg Val Lys 
                325                 330                 335     
Ala Asn Tyr Ile Asp Gln Leu Val Val Ile Thr Gly Gly Ser Ser Thr 
            340                 345                 350         
Ile Glu Pro Pro Ala Gly Tyr Thr Lys Ile Glu Tyr Asp Leu Asn Ala 
        355                 360                 365             
Gly Ala Gly Gly Asp Phe Ile Tyr Leu Cys Tyr His Glu Gln Ala Trp 
    370                 375                 380                 
Tyr Pro Asp Asn Thr Lys Pro Ala Val Thr Ala Ile Lys Ile Ile Tyr 
385                 390                 395                 400 
Asp Arg Glu Pro Val Pro Thr Gly Tyr Ile Lys Leu Pro Gln Asp Leu 
                405                 410                 415     
Asn Lys Gly Ala Gly Gly Ala Asp Ile Tyr Leu Cys Tyr Lys Leu Glu 
            420                 425                 430         
Gly Tyr Asn Thr Asp Thr Ala Ile Asn Lys Val Thr Val Ile Gly Gly 
        435                 440                 445             
Asn Asn Ala Asp Ile Asn Ala Pro Tyr Gly Tyr Leu Lys Val Pro Gly 
    450                 455                 460                 
Asp Leu Asn Arg Gly Ala Gly Gly Asn Phe Ile Tyr Ala Cys Thr Phe 
465                 470                 475                 480 
Val Gly Lys 
            

<210>  177
<211>  482
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  177
Met Glu Asn Ile Asp Leu Pro Gln Gly Leu Val Asn Phe Ser Thr Gln 
1               5                   10                  15      
His Leu Gln Leu Ile Arg Phe Lys Ala Gly Leu Asn Glu Thr Val Leu 
            20                  25                  30          
Pro Gly Val Glu Ala Ile Gly Leu Gly Tyr Asn Pro Phe Ile Ser Tyr 
        35                  40                  45              
Ala Ser Val Asn Ser Gly Ala Val Gln Leu Phe Asp Trp Ala Thr Ala 
    50                  55                  60                  
Lys Lys Arg Glu Val Pro Phe Lys Ala Gly Tyr Phe Val Pro Glu Ile 
65                  70                  75                  80  
Val Asp Val Gln Gln Asn Asp Ser Ala Thr Tyr Thr Asn Val Ser Gly 
                85                  90                  95      
Asn Thr Ile Ser Glu Tyr Gln Arg Ser Leu Ala Thr Ser Val Ala Ile 
            100                 105                 110         
Glu Gly Arg Tyr Asn Phe Phe Ser Gly Ser Leu Ser Thr Asp Phe Asp 
        115                 120                 125             
Ser Asn Ser Leu Arg Asn Ala Glu Asn Glu Phe Thr Arg Ile Gln Gln 
    130                 135                 140                 
Ser Ile Asn Leu Trp Ser Leu Arg Leu Pro Ser Val Lys Ser Leu Arg 
145                 150                 155                 160 
Glu Leu Met Leu Pro His Met Arg Gln Gln Leu Asp Glu Leu Asn Val 
                165                 170                 175     
Asn Asp Pro Lys Ala Ile Ser Arg Tyr Phe Asp Arg Val Gly Ser His 
            180                 185                 190         
Phe Leu Thr Gly Ile Val Met Gly Gly Arg Ala Ile Leu Ala Ser Ser 
        195                 200                 205             
Thr Asn Lys Leu Arg Val Lys Arg Asp Tyr Ser Val Ser Val Ile Ala 
    210                 215                 220                 
Lys Ala Ser Tyr Glu Gly Leu Thr Gly Gln Leu Ser Ala Glu Ala Arg 
225                 230                 235                 240 
Thr Lys Tyr Gly Glu Ser Met Ser Ser Phe Thr Gln Tyr Ser Ser Thr 
                245                 250                 255     
His Gln Glu Val Arg Gly Gly Asp Gly Thr Lys Ala His Gly Val Phe 
            260                 265                 270         
Glu Gly Lys Ala Gly Phe Gln Ala Trp Val Asp Ser Val Gly Thr Ser 
        275                 280                 285             
Pro Asp Phe Val Asp Phe Val Pro Thr Ile Pro Met Gln Glu Ile Trp 
    290                 295                 300                 
Thr Leu Cys Ser Ser Glu Ala Gln Ala Glu Ala Met Arg Lys His Tyr 
305                 310                 315                 320 
Asp Asp Val Trp Ala Pro Ala Gln Ser Glu Lys Tyr Arg Val Lys Ala 
                325                 330                 335     
Asn Tyr Ile Asp Gln Leu Val Val Ile Thr Gly Gly Ser Ser Thr Ile 
            340                 345                 350         
Glu Pro Pro Val Gly Tyr Ser Lys Ile Glu Tyr Asp Leu Asn Ala Gly 
        355                 360                 365             
Ala Gly Gly Asp Phe Ile Tyr Leu Cys Tyr His Glu Gln Thr Trp Gln 
    370                 375                 380                 
Ala Asp Arg Pro Lys Asp Ala Val Thr Asp Ile Arg Ile Ile Phe Asn 
385                 390                 395                 400 
Lys Glu Pro Thr Pro Pro Gly Tyr Thr Lys Leu Pro Gln Asp Leu Asn 
                405                 410                 415     
Lys Gly Ala Gly Gly Asp Asp Val Phe Leu Cys Tyr Lys Thr Glu Ala 
            420                 425                 430         
Tyr Asn Thr Asp Thr Ala Ile Asn Lys Val Thr Val Ile Gly Gly Asn 
        435                 440                 445             
Asn Ala Asp Ile Asn Ala Pro Tyr Gly Tyr Leu Lys Val Pro Gly Asp 
    450                 455                 460                 
Leu Asn Arg Gly Ala Gly Gly Asn Phe Ile Tyr Ala Cys Thr Phe Val 
465                 470                 475                 480 
Gly Lys 
        

<210>  178
<211>  483
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  178
Met Glu Asn Ile Asp Leu Pro Gln Gly Leu Val Asn Phe Ser Thr Gln 
1               5                   10                  15      
His Leu Gln Leu Ile Leu Phe Ile Ala Cys Leu Asn Glu Thr Val Leu 
            20                  25                  30          
Pro Gly Val Glu Ala Ile Gly Leu Gly Tyr Asn Pro Phe Ile Ser Tyr 
        35                  40                  45              
Ala Ser Val Asn Ser Gly Ala Val Gln Leu Phe Asp Trp Ala Thr Ala 
    50                  55                  60                  
Lys Lys Arg Glu Val Pro Phe Lys Ala Gly Tyr Phe Val Pro Glu Ile 
65                  70                  75                  80  
Val Asp Val Gln Gln Asn Asp Ser Ala Thr Tyr Thr Asn Val Ser Gly 
                85                  90                  95      
Asn Thr Ile Ser Glu Tyr Gln Arg Ser Leu Ala Thr Ser Val Ala Ile 
            100                 105                 110         
Glu Gly Arg Tyr Asn Phe Phe Ser Gly Ser Leu Ser Thr Asp Phe Asp 
        115                 120                 125             
Ser Asn Ser Leu Arg Asn Ala Glu Asn Glu Phe Thr Arg Ile Gln Gln 
    130                 135                 140                 
Ser Ile Asn Leu Trp Ser Leu Arg Leu Pro Ser Val Lys Ser Leu Arg 
145                 150                 155                 160 
Glu Leu Met Leu Pro His Met Arg Gln Gln Leu Asp Glu Leu Asn Val 
                165                 170                 175     
Asn Asp Pro Lys Ala Ile Ser Arg Tyr Phe Asp Arg Val Gly Ser His 
            180                 185                 190         
Phe Leu Thr Gly Ile Val Met Gly Gly Arg Ala Ile Leu Ala Ser Ser 
        195                 200                 205             
Thr Asn Lys Leu Arg Val Lys Arg Asp Tyr Ser Val Ser Val Val Ala 
    210                 215                 220                 
Lys Ala Ser Tyr Glu Gly Leu Thr Gly Gln Leu Ser Ala Glu Ala Lys 
225                 230                 235                 240 
Ala Lys Tyr Gly Glu Ser Ile Ser Ser Phe Thr Gln Tyr Ser Asn Thr 
                245                 250                 255     
His Gln Glu Val Arg Gly Gly Asp Gly Ala Lys Ala His Gly Val Phe 
            260                 265                 270         
Ser Gly Lys Lys Glu Asp Phe Gln Ala Trp Val Asp Ser Val Ser Ala 
        275                 280                 285             
Ser Pro Asp Phe Val Asp Phe Val Pro Thr Ile Pro Met Gln Glu Ile 
    290                 295                 300                 
Trp Thr Leu Cys Ser Ser Glu Ala Gln Ala Glu Ala Met Arg Lys His 
305                 310                 315                 320 
Tyr Asp Asp Val Trp Ala Pro Ala Gln Ser Glu Lys Tyr Arg Val Lys 
                325                 330                 335     
Ala Asn Tyr Ile Asp Gln Leu Val Val Ile Thr Gly Gly Ser Ser Thr 
            340                 345                 350         
Ile Glu Pro Pro Val Gly Tyr Ser Lys Ile Glu Tyr Asp Leu Asn Ala 
        355                 360                 365             
Gly Ala Gly Gly Asp Phe Ile Tyr Leu Cys Tyr His Glu Gln Thr Trp 
    370                 375                 380                 
Gln Ala Asp Arg Pro Lys Asp Ala Val Thr Asp Ile Arg Ile Ile Phe 
385                 390                 395                 400 
Asn Lys Glu Pro Thr Pro Pro Gly Tyr Thr Lys Leu Pro Gln Asp Leu 
                405                 410                 415     
Asn Lys Gly Ala Gly Gly Asp Asp Val Phe Leu Cys Tyr Lys Thr Glu 
            420                 425                 430         
Ala Tyr Asn Thr Asp Thr Ala Ile Asn Lys Val Thr Val Ile Gly Gly 
        435                 440                 445             
Asn Asn Ala Asp Ile Asn Ala Pro Tyr Gly Tyr Leu Lys Val Pro Gly 
    450                 455                 460                 
Asp Leu Asn Arg Gly Ala Gly Gly Asn Phe Ile Tyr Ala Cys Thr Phe 
465                 470                 475                 480 
Val Gly Lys 
            

<210>  179
<211>  483
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  179
Met Glu Asn Ile Asp Leu Pro Gln Gly Leu Val Asn Phe Ser Thr Gln 
1               5                   10                  15      
His Leu Gln Leu Ile Arg Phe Lys Ala Gly Leu Asn Glu Thr Val Leu 
            20                  25                  30          
Pro Gly Val Glu Ala Ile Gly Leu Gly Tyr Asn Pro Phe Ile Ser Tyr 
        35                  40                  45              
Ala Ser Val Asn Ser Gly Ala Val Gln Leu Phe Asp Trp Asn Asn Ala 
    50                  55                  60                  
Lys Lys Lys Lys Val Ser Phe Lys Pro Glu Phe Val Val Pro Glu Ile 
65                  70                  75                  80  
Val Asp Val Gln Gln Asn Asp Ser Ala Thr Tyr Thr Asn Val Ser Gly 
                85                  90                  95      
Asn Thr Val Thr Glu Tyr Gln Arg Ser Leu Ala Thr Ser Val Ala Ile 
            100                 105                 110         
Glu Gly Arg Tyr Asn Phe Phe Ser Gly Ser Leu Ser Thr Asp Tyr Asp 
        115                 120                 125             
Glu Asn Ser Leu Arg Asn Ala Glu Asn Glu Phe Thr Arg Ile Gln Gln 
    130                 135                 140                 
Ser Ile Asn Leu Trp Ser Leu Arg Leu Pro Ser Val Lys Ser Leu Arg 
145                 150                 155                 160 
Asp Leu Met Leu Pro His Met Arg Glu Gln Leu Asp Glu Leu Asp Val 
                165                 170                 175     
Lys Asn Pro Ser Ala Ile Ser Arg Phe Phe Asp Arg Val Gly Ser His 
            180                 185                 190         
Phe Leu Thr Gly Ile Val Met Gly Gly Arg Ala Ile Leu Ala Ala Ser 
        195                 200                 205             
Thr Asn Lys Leu Lys Val Lys Arg Asp Tyr Ser Val Ser Val Val Ala 
    210                 215                 220                 
Lys Ala Ser Tyr Glu Gly Leu Thr Gly Gln Leu Ser Ala Glu Ala Lys 
225                 230                 235                 240 
Ala Lys Tyr Gly Glu Ser Ile Ser Ser Phe Thr Gln Tyr Ser Asn Thr 
                245                 250                 255     
His Gln Glu Val Arg Gly Gly Asp Gly Ala Lys Ala His Gly Val Phe 
            260                 265                 270         
Ser Gly Lys Lys Glu Asp Phe Gln Ala Trp Val Asp Ser Val Ser Ala 
        275                 280                 285             
Ser Pro Asp Phe Val Asp Phe Val Pro Thr Ile Pro Met Leu Glu Ile 
    290                 295                 300                 
Trp Thr Leu Cys Ser Ser Glu Ala Gln Ala Glu Ala Met Arg Lys His 
305                 310                 315                 320 
Tyr Asp Asp Val Trp Ala Pro Ala Gln Ser Glu Lys Tyr Arg Val Lys 
                325                 330                 335     
Ala Asn Tyr Ile Asp Gln Leu Val Val Ile Thr Gly Gly Ser Ser Thr 
            340                 345                 350         
Ile Glu Pro Pro Val Gly Tyr Ser Lys Ile Glu Tyr Asp Leu Asn Ala 
        355                 360                 365             
Gly Ala Gly Gly Asp Phe Ile Tyr Leu Cys Tyr His Glu Gln Thr Trp 
    370                 375                 380                 
Gln Ala Asp Arg Pro Lys Asp Ala Val Thr Asp Ile Arg Ile Ile Phe 
385                 390                 395                 400 
Asn Lys Glu Pro Thr Pro Pro Gly Tyr Thr Lys Leu Pro Gln Asp Leu 
                405                 410                 415     
Asn Lys Gly Ala Gly Gly Asp Asp Val Phe Leu Cys Tyr Lys Thr Glu 
            420                 425                 430         
Ala Tyr Asn Thr Asp Thr Ala Ile Asn Lys Val Thr Val Ile Gly Gly 
        435                 440                 445             
Asn Asn Ala Asp Ile Asn Ala Pro Tyr Gly Tyr Leu Lys Val Pro Gly 
    450                 455                 460                 
Asp Leu Asn Arg Gly Ala Gly Gly Asn Phe Ile Tyr Ala Cys Thr Phe 
465                 470                 475                 480 
Val Gly Lys 
            

<210>  180
<211>  482
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  180
Met Glu Asn Ile Asp Leu Pro Gln Gly Leu Val Asn Phe Ser Thr Gln 
1               5                   10                  15      
His Leu Gln Leu Ile Arg Phe Lys Ala Gly Leu Asn Glu Thr Val Leu 
            20                  25                  30          
Pro Gly Val Glu Ala Ile Gly Leu Gly Tyr Asn Pro Phe Leu Gly Tyr 
        35                  40                  45              
Ala Ser Val Asn Ser Gly Ala Val Gln Leu Phe Asp Trp Ala Thr Ala 
    50                  55                  60                  
Lys Lys Arg Glu Val Pro Phe Lys Ala Gly Tyr Phe Val Pro Glu Ile 
65                  70                  75                  80  
Val Asp Val Gln Gln Asn Asp Ser Ala Thr Tyr Thr Asn Val Ser Gly 
                85                  90                  95      
Asn Thr Ile Ser Glu Tyr Gln Arg Ser Leu Ala Thr Ser Val Ala Ile 
            100                 105                 110         
Glu Gly Arg Tyr Asn Phe Phe Ser Gly Ser Leu Ser Thr Asp Tyr Asp 
        115                 120                 125             
Glu Asn Ser Leu Arg Asn Ala Glu Asn Glu Phe Thr Arg Ile Gln Gln 
    130                 135                 140                 
Ser Ile Asn Leu Trp Ser Leu Arg Leu Pro Ser Val Lys Ser Leu Arg 
145                 150                 155                 160 
Asp Leu Met Leu Pro His Met Arg Gln Gln Leu Asp Glu Leu Asn Val 
                165                 170                 175     
Asn Asp Pro Lys Ala Ile Ser Arg Tyr Phe Asp Arg Val Gly Ser His 
            180                 185                 190         
Phe Leu Thr Gly Ile Val Met Gly Gly Arg Ala Ile Leu Ala Ala Ser 
        195                 200                 205             
Thr Asn Lys Leu Arg Val Lys Arg Asp Tyr Ser Val Ser Val Ile Ala 
    210                 215                 220                 
Lys Ala Ser Tyr Glu Gly Leu Thr Gly Gln Leu Ser Ala Glu Ala Arg 
225                 230                 235                 240 
Thr Lys Tyr Gly Glu Ser Met Ser Ser Phe Thr Gln Tyr Ser Ser Thr 
                245                 250                 255     
His Gln Glu Val Arg Gly Gly Asp Gly Thr Lys Ala His Gly Val Phe 
            260                 265                 270         
Glu Gly Lys Ala Gly Phe Gln Ala Trp Val Asp Ser Val Gly Thr Ser 
        275                 280                 285             
Pro Asp Phe Val Asp Phe Val Pro Thr Ile Pro Met Leu Glu Ile Trp 
    290                 295                 300                 
Thr Leu Cys Ser Ser Glu Ala Gln Ala Glu Ala Met Arg Lys His Tyr 
305                 310                 315                 320 
Asp Asp Val Trp Ala Pro Ala Gln Ser Glu Lys Tyr Arg Val Lys Ala 
                325                 330                 335     
Asn Tyr Ile Asp Gln Leu Val Val Ile Thr Gly Gly Ser Ser Thr Ile 
            340                 345                 350         
Glu Pro Pro Val Gly Tyr Ser Lys Ile Glu Tyr Asp Leu Asn Val Gly 
        355                 360                 365             
Ala Gly Gly Asp Phe Ile Tyr Leu Cys Tyr His Glu Gln Thr Trp Gln 
    370                 375                 380                 
Ala Asp Arg Pro Lys Asp Ala Val Thr Asp Ile Arg Ile Ile Phe Asn 
385                 390                 395                 400 
Lys Glu Pro Thr Pro Pro Gly Tyr Thr Lys Leu Pro Gln Asp Leu Asn 
                405                 410                 415     
Lys Gly Ala Gly Gly Asp Asp Val Phe Leu Cys Tyr Lys Thr Glu Ala 
            420                 425                 430         
Tyr Asn Thr Asp Thr Ala Ile Asn Lys Val Thr Val Ile Gly Gly Asn 
        435                 440                 445             
Asn Ala Asp Ile Asn Ala Pro Tyr Gly Tyr Glu Lys Val Pro Gly Asp 
    450                 455                 460                 
Leu Asn Lys Gly Ala Lys Gly Asn Phe Ile Tyr Ala Cys Thr Phe Val 
465                 470                 475                 480 
Gly Lys 
        

<210>  181
<211>  482
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  181
Met Glu Asn Ile Asp Leu Pro Gln Gly Leu Val Asn Phe Ser Thr Gln 
1               5                   10                  15      
His Leu Gln Leu Ile Arg Phe Lys Ala Gly Leu Asn Glu Thr Val Leu 
            20                  25                  30          
Pro Gly Val Glu Ala Ile Gly Leu Gly Tyr Asn Pro Phe Ile Ser Tyr 
        35                  40                  45              
Ala Ser Val Asn Ser Gly Ala Val Gln Leu Phe Asp Trp Ala Thr Ala 
    50                  55                  60                  
Lys Lys Arg Glu Val Pro Phe Lys Ala Gly Tyr Phe Val Pro Glu Ile 
65                  70                  75                  80  
Val Asp Val Gln Gln Asn Asp Ser Ala Thr Tyr Thr Asn Val Ser Gly 
                85                  90                  95      
Asn Thr Val Ser Glu Tyr Gln Arg Ser Leu Ala Thr Ser Val Ala Ile 
            100                 105                 110         
Glu Gly Arg Tyr Asn Phe Phe Ser Gly Ser Leu Ser Thr Asp Tyr Asp 
        115                 120                 125             
Glu Asn Ser Leu Arg Asn Ala Glu Asn Glu Phe Thr Arg Ile Gln Gln 
    130                 135                 140                 
Ser Ile Asn Leu Trp Ser Leu Arg Leu Pro Ser Val Lys Ser Leu Arg 
145                 150                 155                 160 
Asp Leu Met Leu Pro His Met Arg Glu Gln Leu Asp Glu Leu Asp Val 
                165                 170                 175     
Lys Asn Pro Ser Ala Ile Ser Arg Phe Phe Asp Arg Val Gly Ser His 
            180                 185                 190         
Phe Leu Thr Gly Ile Val Met Gly Gly Arg Ala Ile Leu Ala Ser Ser 
        195                 200                 205             
Thr Asn Lys Leu Arg Val Lys Arg Asp Tyr Ser Val Ser Val Val Ala 
    210                 215                 220                 
Lys Ala Ser Tyr Glu Gly Leu Thr Gly Gln Leu Ser Ala Glu Ala Arg 
225                 230                 235                 240 
Thr Lys Tyr Gly Glu Ser Met Ser Ser Phe Thr Gln Tyr Ser Ser Thr 
                245                 250                 255     
His Gln Glu Val Arg Gly Gly Asp Gly Thr Lys Ala His Gly Val Phe 
            260                 265                 270         
Glu Gly Lys Ala Gly Phe Gln Ala Trp Val Asp Ser Val Ser Ala Ser 
        275                 280                 285             
Pro Asp Phe Val Asp Phe Val Pro Thr Ile Pro Met Gln Glu Ile Trp 
    290                 295                 300                 
Thr Leu Cys Ser Ser Glu Ala Gln Ala Glu Ala Met Arg Lys His Tyr 
305                 310                 315                 320 
Asp Asp Val Trp Ala Pro Ala Gln Ser Glu Lys Tyr Arg Val Lys Ala 
                325                 330                 335     
Asn Tyr Ile Asp Gln Leu Val Val Ile Thr Gly Asp Ser Ser Thr Ile 
            340                 345                 350         
Glu Pro Pro Ala Gly Tyr Thr Lys Ile Pro Tyr Asp Leu Asn Ala Gly 
        355                 360                 365             
Ala Lys Gly Asp Phe Ile Tyr Leu Cys Tyr His Glu Gln Ala Trp Tyr 
    370                 375                 380                 
Pro Asp Asn Thr Lys Pro Ala Val Thr Ala Ile Lys Ile Ile Tyr Asp 
385                 390                 395                 400 
Arg Glu Pro Val Pro Thr Gly Tyr Ile Lys Leu Pro Gln Asp Leu Asn 
                405                 410                 415     
Lys Gly Ala Gly Gly Ala Asp Ile Tyr Leu Cys Tyr Lys Leu Glu Gly 
            420                 425                 430         
Tyr Asn Thr Asp Thr Ala Ile Asn Lys Ile Thr Val Ile Ser Gly Asn 
        435                 440                 445             
Asn Pro Asp Ile Asn Ala Pro Tyr Gly Tyr Leu Lys Val Pro Gly Asp 
    450                 455                 460                 
Leu Asn Arg Gly Ala Lys Gly Asn Phe Ile Tyr Ala Cys Thr Phe Val 
465                 470                 475                 480 
Gly Lys 
        

<210>  182
<211>  482
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  182
Met Glu Asn Ile Asp Leu Pro Gln Gly Leu Val Asn Phe Ser Thr Gln 
1               5                   10                  15      
His Leu Gln Leu Ile Arg Phe Lys Ala Gly Leu Asn Glu Thr Val Leu 
            20                  25                  30          
Pro Gly Val Glu Ala Ile Gly Leu Gly Tyr Asn Pro Phe Ile Ser Tyr 
        35                  40                  45              
Ala Ser Val Asn Ser Gly Ala Val Gln Leu Phe Asp Trp Ala Thr Ala 
    50                  55                  60                  
Lys Lys Arg Glu Val Pro Phe Lys Ala Gly Tyr Phe Val Pro Glu Ile 
65                  70                  75                  80  
Val Asp Val Gln Gln Asn Asp Ser Ala Ser Tyr Thr Asn Val Ser Gly 
                85                  90                  95      
Asn Thr Ile Ser Glu Tyr Gln Arg Ser Leu Ala Thr Ser Val Ala Ile 
            100                 105                 110         
Glu Gly Arg Tyr Asn Phe Phe Ser Gly Ser Leu Ser Thr Asp Tyr Asp 
        115                 120                 125             
Glu Asn Ser Leu Arg Asn Ala Glu Asn Glu Phe Thr Arg Ile Gln Gln 
    130                 135                 140                 
Ser Ile Asn Leu Trp Ser Leu Arg Leu Pro Ser Val Lys Ser Leu Arg 
145                 150                 155                 160 
Asp Leu Met Leu Pro His Met Arg Glu Gln Leu Asp Glu Leu Asp Val 
                165                 170                 175     
Lys Asn Pro Ser Ala Ile Ser Arg Phe Phe Asp Arg Val Gly Ser His 
            180                 185                 190         
Phe Leu Thr Gly Ile Val Met Gly Gly Arg Ala Ile Leu Ala Ala Ser 
        195                 200                 205             
Thr Asn Lys Leu Lys Val Lys Arg Asp Tyr Ser Val Ser Val Ile Ala 
    210                 215                 220                 
Lys Ala Ser Tyr Glu Gly Leu Thr Gly Gln Leu Ser Ala Glu Ala Lys 
225                 230                 235                 240 
Ala Lys Tyr Gly Glu Ser Ile Ser Ser Phe Thr Gln Tyr Ser Asn Thr 
                245                 250                 255     
His Gln Glu Val Arg Gly Gly Asp Gly Thr Lys Ala His Gly Val Phe 
            260                 265                 270         
Glu Gly Lys Ala Gly Phe Gln Ala Trp Val Asp Ser Val Gly Thr Ser 
        275                 280                 285             
Pro Asp Phe Val Asp Phe Val Pro Thr Ile Pro Met Leu Glu Ile Trp 
    290                 295                 300                 
Thr Leu Cys Ser Ser Glu Ala Gln Ala Glu Ala Met Arg Lys His Tyr 
305                 310                 315                 320 
Asp Asp Val Trp Ala Pro Ala Gln Ser Glu Lys Tyr Arg Val Lys Ala 
                325                 330                 335     
Asn Tyr Ile Asp Gln Leu Val Val Ile Thr Gly Asp Ser Ser Thr Ile 
            340                 345                 350         
Glu Pro Pro Ala Gly Tyr Thr Lys Ile Pro Tyr Asp Leu Asn Ala Gly 
        355                 360                 365             
Ala Lys Gly Asp Phe Ile Tyr Leu Cys Tyr His Glu Gln Ala Trp Tyr 
    370                 375                 380                 
Pro Asp Asn Thr Lys Pro Ala Val Thr Ala Ile Lys Ile Ile Tyr Asp 
385                 390                 395                 400 
Arg Glu Pro Val Pro Thr Gly Tyr Ile Lys Leu Pro Gln Asp Leu Asn 
                405                 410                 415     
Lys Gly Ala Gly Gly Ala Asp Ile Tyr Leu Cys Tyr Lys Thr Glu Ala 
            420                 425                 430         
Tyr Asn Thr Asp Thr Ala Ile Asn Lys Val Thr Val Ile Gly Gly Asn 
        435                 440                 445             
Asn Ala Asp Ile Asn Ala Pro Tyr Gly Tyr Leu Lys Val Pro Gly Asp 
    450                 455                 460                 
Leu Asn Arg Gly Ala Gly Gly Asn Phe Ile Tyr Ala Cys Thr Phe Val 
465                 470                 475                 480 
Gly Lys 
        

<210>  183
<211>  483
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  183
Met Glu Asn Ile Asp Leu Pro Gln Gly Leu Val Asn Phe Ser Thr Gln 
1               5                   10                  15      
His Leu Gln Leu Ile Arg Phe Lys Ala Gly Leu Asn Glu Thr Val Leu 
            20                  25                  30          
Pro Gly Val Glu Ala Ile Gly Leu Gly Tyr Asn Pro Phe Ile Ser Tyr 
        35                  40                  45              
Ala Ser Val Asn Ser Gly Ala Val Gln Leu Phe Asp Trp Ala Thr Ala 
    50                  55                  60                  
Lys Lys Arg Glu Val Pro Phe Lys Ala Gly Tyr Phe Val Pro Glu Ile 
65                  70                  75                  80  
Val Asp Val Gln Gln Asn Asp Ser Ala Thr Tyr Thr Asn Val Ser Gly 
                85                  90                  95      
Asn Thr Ile Ser Glu Tyr Gln Arg Ser Leu Ala Thr Ser Val Ala Ile 
            100                 105                 110         
Glu Gly Arg Tyr Asn Phe Phe Ser Gly Ser Leu Ser Thr Asp Phe Asp 
        115                 120                 125             
Ser Asn Ser Leu Arg Asn Ala Glu Asn Glu Phe Thr Arg Ile Gln Gln 
    130                 135                 140                 
Ser Ile Asn Leu Trp Ser Leu Arg Leu Pro Ser Val Lys Ser Leu Arg 
145                 150                 155                 160 
Glu Leu Met Leu Pro His Met Arg Glu Gln Leu Asp Glu Leu Asp Val 
                165                 170                 175     
Lys Asn Pro Ser Ala Ile Ser Arg Phe Phe Asp Arg Val Gly Ser His 
            180                 185                 190         
Phe Leu Thr Gly Ile Val Met Gly Gly Arg Ala Ile Leu Ala Ser Ser 
        195                 200                 205             
Thr Asn Lys Leu Arg Val Lys Arg Asp Tyr Ser Val Ser Val Val Ala 
    210                 215                 220                 
Lys Ala Ser Tyr Glu Gly Leu Thr Gly Gln Leu Ser Ala Glu Ala Lys 
225                 230                 235                 240 
Ala Lys Tyr Gly Glu Ser Ile Ser Ser Phe Thr Gln Tyr Ser Asn Thr 
                245                 250                 255     
His Gln Glu Val Arg Gly Gly Asp Gly Ala Lys Ala His Gly Val Phe 
            260                 265                 270         
Ser Gly Lys Lys Glu Asp Phe Gln Ala Trp Val Asp Ser Val Ser Ala 
        275                 280                 285             
Ser Pro Asp Phe Val Asp Phe Val Pro Thr Ile Pro Met Gln Glu Ile 
    290                 295                 300                 
Trp Thr Leu Cys Ser Ser Glu Ala Gln Ala Glu Ala Met Arg Lys His 
305                 310                 315                 320 
Tyr Asp Asp Val Trp Ala Pro Ala Gln Ser Glu Lys Tyr Arg Val Lys 
                325                 330                 335     
Ala Asn Tyr Ile Asp Gln Leu Val Val Ile Thr Gly Asp Ser Ser Thr 
            340                 345                 350         
Ile Glu Pro Pro Ala Gly Tyr Thr Lys Ile Pro Tyr Asp Leu Asn Ala 
        355                 360                 365             
Gly Ala Lys Gly Asp Phe Ile Tyr Leu Cys Tyr His Glu Gln Ala Trp 
    370                 375                 380                 
Tyr Pro Asp Asn Thr Lys Pro Ala Val Thr Ala Ile Lys Ile Ile Tyr 
385                 390                 395                 400 
Asp Arg Glu Pro Val Pro Thr Gly Tyr Ile Lys Leu Pro Gln Asp Leu 
                405                 410                 415     
Asn Lys Gly Ala Gly Gly Ala Asp Ile Tyr Leu Cys Tyr Lys Thr Glu 
            420                 425                 430         
Ala Tyr Asn Thr Asp Thr Ala Ile Asn Lys Val Thr Val Ile Gly Gly 
        435                 440                 445             
Asn Asn Ala Asp Ile Asn Ala Pro Tyr Gly Tyr Glu Lys Val Pro Gly 
    450                 455                 460                 
Asp Leu Asn Lys Gly Ala Lys Gly Asn Phe Ile Tyr Ala Cys Thr Phe 
465                 470                 475                 480 
Val Gly Lys 
            

<210>  184
<211>  483
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  184
Met Glu Asn Ile Asp Leu Pro Gln Gly Leu Val Asn Phe Ser Thr Gln 
1               5                   10                  15      
His Pro Gln Leu Ile Arg Phe Lys Ala Gly Leu Asn Glu Thr Val Leu 
            20                  25                  30          
Pro Gly Val Glu Ala Ile Gly Leu Gly Tyr Asn Pro Phe Ile Ser Tyr 
        35                  40                  45              
Ala Ser Val Asn Ser Gly Ala Val Gln Leu Phe Asp Trp Ala Thr Ala 
    50                  55                  60                  
Lys Lys Arg Glu Val Pro Phe Lys Ala Gly Tyr Phe Val Pro Glu Ile 
65                  70                  75                  80  
Val Asp Val Gln Gln Asn Asp Ser Ala Thr Tyr Thr Asn Val Ser Asp 
                85                  90                  95      
Asn Thr Val Thr Glu Tyr Gln Arg Ser Leu Ala Val Ser Val Ala Ile 
            100                 105                 110         
Glu Gly Lys Tyr Asn Phe Phe Ser Gly Ser Leu Ser Thr Asp Tyr Asp 
        115                 120                 125             
Glu Asn Ser Leu Arg Asn Ala Glu Asn Glu Phe Thr Arg Ile Gln Gln 
    130                 135                 140                 
Ser Ile Asn Leu Trp Ser Leu Arg Leu Pro Ser Val Lys Ser Leu Arg 
145                 150                 155                 160 
Asp Leu Met Leu Pro His Met Arg Glu Gln Leu Asp Glu Leu Asp Val 
                165                 170                 175     
Lys Asn Pro Ser Ala Ile Ser Arg Phe Phe Asp Arg Val Gly Ser His 
            180                 185                 190         
Phe Leu Thr Gly Ile Val Met Gly Gly Arg Ala Ile Leu Ala Ala Ser 
        195                 200                 205             
Thr Asn Lys Leu Arg Val Lys Arg Asp Tyr Ser Val Ser Val Val Ala 
    210                 215                 220                 
Lys Ala Ser Tyr Glu Gly Leu Thr Gly Gln Leu Ser Ala Glu Ala Lys 
225                 230                 235                 240 
Ala Lys Tyr Gly Glu Ser Ile Ser Ser Phe Thr Gln Tyr Ser Ser Thr 
                245                 250                 255     
His Gln Glu Val Arg Gly Gly Asp Gly Thr Lys Ala His Gly Val Phe 
            260                 265                 270         
Ser Gly Lys Lys Glu Asp Phe Gln Ala Trp Val Asp Ser Val Ser Ala 
        275                 280                 285             
Ser Pro Asp Phe Val Asp Phe Val Pro Thr Ile Pro Met Gln Glu Ile 
    290                 295                 300                 
Trp Thr Leu Cys Ser Ser Glu Ala Gln Ala Glu Ala Met Arg Lys His 
305                 310                 315                 320 
Tyr Asp Asp Val Trp Ala Pro Ala Gln Ser Glu Lys Tyr Arg Val Lys 
                325                 330                 335     
Ala Asn Tyr Ile Asp Gln Leu Val Val Ile Thr Gly Gly Ser Ser Thr 
            340                 345                 350         
Ile Glu Pro Pro Ala Gly Tyr Thr Lys Ile Pro Tyr Asp Leu Asn Ala 
        355                 360                 365             
Gly Ala Lys Gly Asp Phe Ile Tyr Leu Cys Tyr His Glu Gln Ala Trp 
    370                 375                 380                 
Tyr Pro Asp Asn Thr Lys Pro Ala Val Thr Ala Ile Lys Ile Ile Tyr 
385                 390                 395                 400 
Asp Arg Glu Pro Val Pro Thr Gly Tyr Ile Lys Leu Pro Gln Asp Leu 
                405                 410                 415     
Asn Lys Gly Ala Gly Gly Ala Asp Ile Tyr Leu Cys Tyr Lys Leu Glu 
            420                 425                 430         
Gly Tyr Asn Thr Asp Thr Ala Ile Asn Lys Val Thr Val Ile Ser Gly 
        435                 440                 445             
Asn Asn Ala Asp Ile Asn Ala Pro Tyr Gly Tyr Leu Lys Val Pro Gly 
    450                 455                 460                 
Asp Leu Asn Arg Gly Ala Gly Gly Asn Phe Ile Tyr Ala Cys Thr Phe 
465                 470                 475                 480 
Val Gly Lys 
            

<210>  185
<211>  482
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  185
Met Glu Asn Ile Asp Leu Pro Gln Gly Leu Val Asn Phe Ser Thr Gln 
1               5                   10                  15      
His Leu Gln Leu Ile Arg Phe Lys Ala Gly Leu Asn Glu Thr Val Leu 
            20                  25                  30          
Pro Gly Val Glu Ala Ile Gly Leu Gly Tyr Asn Pro Phe Ile Ser Tyr 
        35                  40                  45              
Ala Ser Val Asn Ser Gly Ala Val Gln Leu Phe Asp Trp Ala Thr Ala 
    50                  55                  60                  
Lys Lys Arg Glu Val Pro Phe Lys Ala Gly Tyr Phe Val Pro Glu Ile 
65                  70                  75                  80  
Val Asp Val Gln Gln Asn Asp Ser Ala Thr Tyr Thr Asn Val Ser Gly 
                85                  90                  95      
Asn Thr Val Thr Glu Tyr Gln Arg Ser Leu Ala Val Ser Val Ala Ile 
            100                 105                 110         
Glu Gly Lys Tyr Asn Phe Phe Ser Gly Ser Leu Ser Thr Asp Tyr Asp 
        115                 120                 125             
Glu Asn Ser Leu Arg Asn Ala Glu Asn Glu Phe Thr Arg Ile Gln Gln 
    130                 135                 140                 
Ser Ile Asn Leu Trp Ser Leu Arg Leu Pro Ser Val Lys Ser Leu Arg 
145                 150                 155                 160 
Asp Leu Met Leu Pro His Met Arg Glu Gln Leu Asp Glu Leu Asp Val 
                165                 170                 175     
Lys Asn Pro Ser Ala Ile Ser Arg Phe Phe Asp Arg Val Gly Ser His 
            180                 185                 190         
Phe Leu Thr Gly Ile Val Met Gly Gly Arg Ala Ile Leu Ala Ala Ser 
        195                 200                 205             
Thr Asn Lys Leu Lys Val Lys Arg Asp Tyr Ser Val Ser Val Ile Ala 
    210                 215                 220                 
Lys Ala Ser Tyr Glu Gly Leu Thr Gly Gln Leu Ser Ala Glu Ala Arg 
225                 230                 235                 240 
Thr Lys Tyr Gly Glu Ser Ile Ser Ser Phe Thr Gln Tyr Ser Asn Thr 
                245                 250                 255     
His Gln Glu Val Arg Gly Gly Asp Gly Ala Lys Ala His Gly Val Phe 
            260                 265                 270         
Glu Gly Lys Ala Gly Phe Gln Ala Trp Val Asp Ser Val Gly Thr Ser 
        275                 280                 285             
Pro Asp Phe Val Asp Phe Val Pro Thr Ile Pro Met Gln Glu Ile Trp 
    290                 295                 300                 
Thr Leu Cys Ser Ser Glu Ala Gln Ala Glu Ala Met Arg Lys His Tyr 
305                 310                 315                 320 
Asp Asp Val Trp Ala Pro Ala Gln Ser Glu Lys Tyr Arg Val Lys Ala 
                325                 330                 335     
Asn Tyr Ile Asp Gln Leu Val Val Ile Thr Gly Gly Ser Ser Thr Ile 
            340                 345                 350         
Glu Pro Pro Val Gly Tyr Ser Lys Ile Glu Tyr Asp Leu Asn Ala Gly 
        355                 360                 365             
Ala Gly Gly Asp Phe Ile Tyr Leu Cys Tyr His Lys Gln Thr Trp Gln 
    370                 375                 380                 
Ala Asp Arg Pro Lys Asp Ala Val Thr Asp Ile Arg Ile Ile Phe Asn 
385                 390                 395                 400 
Lys Glu Pro Thr Pro Pro Gly Tyr Thr Lys Leu Pro Gln Asp Leu Asn 
                405                 410                 415     
Lys Gly Ala Gly Gly Asp Asp Val Phe Leu Cys Tyr Lys Thr Glu Ala 
            420                 425                 430         
Tyr Asn Thr Asp Thr Ala Ile Asn Lys Ile Thr Val Ile Ser Gly Asn 
        435                 440                 445             
Asn Pro Asp Ile Asn Ala Pro Tyr Gly Tyr Glu Lys Val Pro Gly Asp 
    450                 455                 460                 
Leu Asn Lys Gly Ala Lys Gly Asn Phe Ile Tyr Ala Cys Thr Phe Val 
465                 470                 475                 480 
Gly Lys 
        

<210>  186
<211>  483
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  186
Met Glu Asn Ile Asp Leu Pro Gln Gly Leu Val Asn Phe Ser Thr Gln 
1               5                   10                  15      
His Leu Gln Leu Ile Arg Phe Lys Ala Gly Leu Asn Glu Thr Val Leu 
            20                  25                  30          
Pro Gly Val Glu Ala Ile Gly Leu Gly Tyr Asn Pro Phe Ile Ser Tyr 
        35                  40                  45              
Ala Ser Val Asn Ser Gly Ala Val Gln Leu Phe Asp Trp Ala Thr Ala 
    50                  55                  60                  
Lys Lys Arg Glu Val Pro Phe Lys Ala Gly Tyr Phe Val Pro Glu Ile 
65                  70                  75                  80  
Val Asp Val Gln Gln Asn Asp Ser Ala Thr Tyr Thr Asn Val Ser Gly 
                85                  90                  95      
Asn Thr Ile Ser Glu Tyr Gln Arg Ser Leu Ala Thr Ser Val Ala Ile 
            100                 105                 110         
Glu Gly Lys Tyr Asn Phe Phe Ser Gly Ser Leu Ser Thr Asp Phe Asp 
        115                 120                 125             
Ser Asn Ser Leu Arg Asn Ala Glu Asn Glu Phe Thr Arg Ile Gln Gln 
    130                 135                 140                 
Ser Ile Asn Leu Trp Ser Leu Arg Leu Pro Ser Val Lys Ser Leu Arg 
145                 150                 155                 160 
Glu Leu Met Leu Pro His Met Arg Gln Gln Leu Asp Glu Leu Asn Val 
                165                 170                 175     
Asn Asp Pro Lys Ala Ile Ser Arg Tyr Phe Asp Arg Val Gly Ser His 
            180                 185                 190         
Phe Leu Thr Gly Ile Val Met Gly Gly Arg Ala Ile Leu Ala Ser Ser 
        195                 200                 205             
Thr Asn Lys Leu Lys Val Lys Arg Asp Tyr Ser Val Ser Val Ile Ala 
    210                 215                 220                 
Lys Ala Ser Tyr Glu Gly Leu Thr Gly Gln Leu Ser Ala Glu Ala Lys 
225                 230                 235                 240 
Ala Lys Tyr Gly Glu Ser Ile Ser Ser Phe Thr Gln Tyr Ser Asn Thr 
                245                 250                 255     
His Gln Glu Val Arg Gly Gly Asp Gly Ala Lys Ala His Gly Val Phe 
            260                 265                 270         
Ser Gly Lys Lys Glu Asp Phe Gln Ala Trp Val Asp Ser Val Ser Ala 
        275                 280                 285             
Ser Pro Asp Phe Val Asp Phe Val Pro Thr Ile Pro Met Gln Glu Ile 
    290                 295                 300                 
Trp Thr Leu Cys Ser Ser Glu Ala Gln Ala Glu Ala Met Arg Lys His 
305                 310                 315                 320 
Tyr Asp Asp Val Trp Ala Pro Ala Gln Ser Asp Lys Tyr Arg Ile Lys 
                325                 330                 335     
Ala Asn Tyr Ile Asp Gln Leu Val Val Ile Thr Gly Gly Ser Ser Thr 
            340                 345                 350         
Ile Glu Pro Pro Ala Gly Tyr Ser Lys Ile Glu Tyr Asp Leu Asn Ala 
        355                 360                 365             
Gly Ala Gly Gly Asp Phe Ile Tyr Leu Cys Tyr His Glu Gln Thr Trp 
    370                 375                 380                 
Gln Ala Asp Arg Pro Lys Asp Ala Val Thr Asp Ile Arg Ile Ile Phe 
385                 390                 395                 400 
Asn Lys Glu Pro Thr Pro Pro Gly Tyr Thr Lys Leu Pro Gln Asp Leu 
                405                 410                 415     
Asn Lys Gly Ala Gly Gly Asp Asp Val Phe Leu Cys Tyr Lys Thr Glu 
            420                 425                 430         
Ala Tyr Asn Thr Asp Thr Ala Ile Asn Lys Val Thr Val Ile Gly Gly 
        435                 440                 445             
Asn Asn Ala Asp Ile Asn Ala Pro Tyr Gly Tyr Leu Lys Val Pro Gly 
    450                 455                 460                 
Asp Leu Asn Lys Gly Ala Lys Gly Asn Phe Ile Tyr Ala Cys Thr Phe 
465                 470                 475                 480 
Val Gly Lys 
            

<210>  187
<211>  483
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  187
Met Glu Asn Ile Asp Leu Pro Gln Gly Leu Val Asn Phe Ser Thr Gln 
1               5                   10                  15      
His Leu Gln Leu Ile Arg Phe Lys Ala Gly Leu Asn Glu Thr Val Leu 
            20                  25                  30          
Pro Gly Val Glu Ala Ile Gly Leu Gly Tyr Asn Pro Phe Ile Ser Tyr 
        35                  40                  45              
Ala Ser Val Asn Ser Gly Ala Val Gln Leu Phe Asp Trp Ala Thr Ala 
    50                  55                  60                  
Lys Lys Arg Glu Val Pro Phe Lys Ala Gly Tyr Phe Val Pro Glu Ile 
65                  70                  75                  80  
Val Asp Val Gln Gln Asn Asp Ser Ala Thr Tyr Thr Asn Val Ser Gly 
                85                  90                  95      
Asn Thr Val Thr Glu Tyr Gln Arg Ser Leu Ala Val Ser Val Ala Ile 
            100                 105                 110         
Glu Gly Lys Tyr Asn Phe Phe Ser Gly Ser Leu Ser Thr Asp Tyr Asp 
        115                 120                 125             
Glu Asn Ser Leu Arg Asn Ala Glu Asn Glu Phe Thr Arg Ile Gln Gln 
    130                 135                 140                 
Ser Ile Asn Leu Trp Ser Leu Arg Leu Pro Ser Val Lys Ser Leu Arg 
145                 150                 155                 160 
Asp Leu Met Leu Pro His Met Arg Gln Gln Leu Asp Glu Leu Asn Val 
                165                 170                 175     
Asn Asp Pro Lys Ala Ile Ser Arg Tyr Phe Asp Arg Val Gly Ser His 
            180                 185                 190         
Phe Leu Thr Gly Ile Val Met Gly Gly Arg Ala Ile Leu Ala Ser Ser 
        195                 200                 205             
Thr Asn Lys Leu Arg Val Lys Arg Asp Tyr Ser Val Ser Val Val Ala 
    210                 215                 220                 
Lys Ala Ser Tyr Glu Gly Leu Thr Gly Gln Leu Ser Ala Glu Ala Lys 
225                 230                 235                 240 
Ala Lys Tyr Gly Glu Ser Ile Ser Ser Phe Thr Gln Tyr Ser Asn Thr 
                245                 250                 255     
His Gln Glu Val Arg Gly Gly Asp Gly Ala Lys Ala His Gly Val Phe 
            260                 265                 270         
Ser Gly Lys Lys Glu Asp Phe Gln Ala Trp Val Asp Ser Val Gly Thr 
        275                 280                 285             
Ser Pro Asp Phe Val Asp Phe Val Pro Thr Ile Pro Met Leu Glu Ile 
    290                 295                 300                 
Trp Ser Leu Cys Lys Thr Asp Ser Gln Ala Glu Ala Met Lys Arg His 
305                 310                 315                 320 
Phe Asp Thr Val Trp Ala Arg Glu Gln Ser Asp Lys Tyr Arg Ile Lys 
                325                 330                 335     
Ala Asn Tyr Ile Asp Gln Leu Val Val Ile Thr Gly Asp Ser Ser Thr 
            340                 345                 350         
Ile Glu Pro Pro Ala Gly Tyr Thr Lys Ile Pro Tyr Asp Leu Asn Ala 
        355                 360                 365             
Gly Ala Lys Gly Asp Phe Ile Tyr Leu Cys Tyr His Glu Gln Ala Trp 
    370                 375                 380                 
Tyr Pro Asp Asn Thr Lys Pro Ala Val Thr Ala Ile Lys Ile Ile Tyr 
385                 390                 395                 400 
Asp Arg Glu Pro Val Pro Thr Gly Tyr Ile Lys Leu Pro Gln Asp Leu 
                405                 410                 415     
Asn Lys Gly Ala Gly Gly Ala Asp Ile Tyr Leu Cys Tyr Lys Leu Glu 
            420                 425                 430         
Gly Tyr Asn Thr Asp Thr Ala Ile Asn Lys Ile Thr Val Ile Ser Gly 
        435                 440                 445             
Asn Asn Ala Asp Ile Asn Ala Pro Tyr Gly Tyr Leu Lys Val Pro Gly 
    450                 455                 460                 
Asp Leu Asn Arg Gly Ala Gly Gly Asn Phe Ile Tyr Ala Cys Thr Phe 
465                 470                 475                 480 
Val Gly Lys 
            

<210>  188
<211>  482
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  188
Met Glu Asn Ile Asp Leu Pro Gln Gly Leu Val Asn Phe Ser Thr Gln 
1               5                   10                  15      
His Leu Gln Leu Ile Arg Phe Lys Ala Gly Leu Asn Glu Thr Val Leu 
            20                  25                  30          
Pro Gly Val Glu Ala Ile Gly Leu Gly Tyr Asn Pro Phe Ile Ser Tyr 
        35                  40                  45              
Ala Ser Val Asn Ser Gly Ala Val Gln Leu Phe Asp Trp Ala Thr Ala 
    50                  55                  60                  
Lys Lys Arg Glu Val Pro Phe Lys Ala Gly Tyr Phe Val Pro Glu Ile 
65                  70                  75                  80  
Val Asp Val Gln Gln Asn Asp Ser Ala Thr Tyr Thr Asn Val Ser Gly 
                85                  90                  95      
Asn Thr Ile Ser Glu Tyr Gln Arg Ser Leu Ala Thr Ser Val Ala Ile 
            100                 105                 110         
Glu Gly Arg Tyr Asn Phe Phe Ser Gly Ser Leu Ser Thr Asp Phe Asp 
        115                 120                 125             
Ser Asn Ser Leu Arg Asn Ala Glu Asn Glu Phe Thr Arg Ile Gln Gln 
    130                 135                 140                 
Ser Ile Asn Leu Trp Ser Leu Arg Leu Pro Ser Val Lys Ser Leu Arg 
145                 150                 155                 160 
Glu Leu Met Leu Pro His Met Arg Gln Gln Leu Asp Glu Leu Asn Val 
                165                 170                 175     
Asn Asp Pro Lys Ala Ile Ser Arg Tyr Phe Asp Arg Val Gly Ser His 
            180                 185                 190         
Phe Leu Thr Gly Ile Val Met Gly Gly Arg Ala Ile Leu Ala Ser Ser 
        195                 200                 205             
Thr Asn Lys Leu Arg Val Lys Arg Asp Tyr Ser Val Ser Val Ile Ala 
    210                 215                 220                 
Lys Ala Ser Tyr Glu Gly Leu Thr Gly Gln Leu Ser Ala Glu Ala Arg 
225                 230                 235                 240 
Thr Lys Tyr Gly Glu Ser Met Ser Ser Phe Thr Gln Tyr Ser Ser Thr 
                245                 250                 255     
His Gln Glu Val Arg Gly Gly Asp Gly Thr Lys Ala His Gly Val Phe 
            260                 265                 270         
Glu Gly Lys Ala Gly Phe Gln Ala Trp Val Asp Ser Val Gly Thr Ser 
        275                 280                 285             
Pro Asp Phe Val Asp Phe Val Pro Thr Ile Pro Met Gln Glu Ile Trp 
    290                 295                 300                 
Thr Leu Cys Ser Ser Glu Ala Gln Ala Glu Ala Met Arg Lys His Tyr 
305                 310                 315                 320 
Asp Asp Val Trp Ala Pro Ala Gln Ser Glu Lys Tyr Arg Val Lys Ala 
                325                 330                 335     
Asn Tyr Ile Asp Gln Leu Val Val Ile Thr Gly Asp Ser Ser Thr Ile 
            340                 345                 350         
Glu Pro Pro Ala Gly Tyr Thr Lys Ile Pro Tyr Asp Leu Asn Ala Gly 
        355                 360                 365             
Ala Gly Gly Asp Phe Ile Tyr Leu Cys Tyr His Glu Gln Thr Trp Gln 
    370                 375                 380                 
Ala Asp Arg Pro Lys Asp Ala Val Thr Asp Ile Arg Ile Ile Phe Asn 
385                 390                 395                 400 
Lys Glu Pro Thr Pro Pro Gly Tyr Thr Lys Leu Pro Gln Asp Leu Asn 
                405                 410                 415     
Lys Gly Ala Gly Gly Asp Asp Val Phe Leu Cys Tyr Lys Thr Glu Ala 
            420                 425                 430         
Tyr Asn Thr Asp Thr Ala Ile Asn Lys Ile Thr Val Ile Gly Gly Asn 
        435                 440                 445             
Asn Ala Asp Ile Asn Ala Pro Tyr Gly Tyr Leu Lys Val Pro Gly Asp 
    450                 455                 460                 
Leu Asn Arg Gly Ala Gly Gly Asn Phe Ile Tyr Ala Cys Thr Phe Val 
465                 470                 475                 480 
Gly Lys 
        

<210>  189
<211>  483
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  189
Met Glu Asn Ile Asp Leu Pro Gln Gly Leu Val Asn Phe Ser Thr Gln 
1               5                   10                  15      
His Leu Gln Leu Ile Arg Phe Lys Ala Gly Leu Asn Glu Thr Val Leu 
            20                  25                  30          
Pro Gly Val Glu Ala Ile Gly Leu Gly Tyr Asn Pro Phe Ile Ser Tyr 
        35                  40                  45              
Ala Ser Val Asn Ser Gly Ala Val Gln Leu Phe Asp Trp Ala Thr Ala 
    50                  55                  60                  
Lys Lys Arg Glu Val Pro Phe Lys Ala Gly Tyr Phe Val Pro Glu Ile 
65                  70                  75                  80  
Val Asp Val Gln Gln Asn Asp Ser Ala Ser Tyr Thr Asn Val Ser Gly 
                85                  90                  95      
Asn Thr Ile Ser Glu Tyr Gln Arg Ser Leu Ala Val Ser Val Ala Ile 
            100                 105                 110         
Glu Gly Lys Tyr Asn Phe Phe Ser Gly Ser Leu Ser Thr Asp Tyr Asp 
        115                 120                 125             
Glu Asn Ser Leu Arg Asn Ala Glu Asn Glu Phe Thr Arg Ile Gln Gln 
    130                 135                 140                 
Ser Ile Asn Leu Trp Ser Leu Arg Leu Pro Ser Val Lys Ser Leu Arg 
145                 150                 155                 160 
Asp Leu Met Leu Pro His Met Arg Gln Gln Leu Asp Glu Leu Asn Val 
                165                 170                 175     
Asn Asp Pro Lys Ala Ile Ser Arg Tyr Phe Asp Arg Val Gly Ser His 
            180                 185                 190         
Phe Leu Thr Gly Ile Val Met Gly Gly Arg Ala Ile Leu Ala Ser Ser 
        195                 200                 205             
Thr Asn Lys Leu Arg Val Lys Arg Asp Tyr Ser Val Ser Val Val Ala 
    210                 215                 220                 
Lys Ala Ser Tyr Glu Gly Leu Thr Gly Gln Leu Ser Ala Glu Ala Lys 
225                 230                 235                 240 
Ala Lys Tyr Gly Glu Ser Ile Ser Ser Phe Thr Gln Tyr Ser Asn Thr 
                245                 250                 255     
His Gln Glu Val Arg Gly Gly Asp Gly Ala Lys Ala His Gly Val Phe 
            260                 265                 270         
Ser Gly Lys Lys Glu Asp Phe Gln Ala Trp Val Asp Ser Val Ser Ala 
        275                 280                 285             
Ser Pro Asp Phe Val Asp Phe Val Pro Thr Ile Pro Met Gln Glu Ile 
    290                 295                 300                 
Trp Thr Leu Cys Ser Ser Glu Ala Gln Ala Glu Ala Met Arg Lys His 
305                 310                 315                 320 
Tyr Asp Asp Val Trp Ala Pro Ala Gln Ser Glu Lys Tyr Arg Val Lys 
                325                 330                 335     
Ala Asn Tyr Ile Asp Gln Leu Val Val Ile Thr Gly Asp Ser Ser Thr 
            340                 345                 350         
Ile Glu Pro Pro Ala Gly Tyr Thr Lys Ile Pro Tyr Asp Leu Asn Ala 
        355                 360                 365             
Gly Ala Lys Gly Asp Phe Ile Tyr Leu Cys Tyr His Glu Gln Thr Trp 
    370                 375                 380                 
Gln Ala Asp Arg Pro Lys Asp Ala Val Thr Asp Ile Arg Ile Ile Phe 
385                 390                 395                 400 
Asn Lys Glu Pro Thr Pro Pro Gly Tyr Thr Lys Leu Pro Gln Asp Leu 
                405                 410                 415     
Asn Lys Gly Ala Gly Gly Asp Asp Val Phe Leu Cys Tyr Lys Thr Glu 
            420                 425                 430         
Ala Tyr Asn Thr Asp Thr Ala Ile Asn Lys Val Thr Val Ile Gly Gly 
        435                 440                 445             
Asn Asn Ala Asp Ile Asn Ala Pro Tyr Gly Tyr Leu Lys Val Pro Gly 
    450                 455                 460                 
Asp Leu Asn Arg Gly Ala Gly Gly Asn Phe Ile Tyr Ala Cys Thr Phe 
465                 470                 475                 480 
Val Gly Lys 
            

<210>  190
<211>  482
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  190
Met Glu Asn Ile Asp Leu Pro Gln Gly Leu Val Asn Phe Ser Thr Gln 
1               5                   10                  15      
His Leu Gln Leu Ile Arg Phe Lys Ala Gly Leu Asn Glu Thr Val Leu 
            20                  25                  30          
Pro Gly Val Glu Ala Ile Gly Leu Gly Tyr Asn Pro Phe Ile Ser Tyr 
        35                  40                  45              
Ala Ser Val Asn Ser Gly Ala Val Gln Leu Phe Asp Trp Ala Thr Ala 
    50                  55                  60                  
Lys Lys Arg Glu Val Pro Phe Lys Ala Gly Tyr Phe Val Pro Glu Ile 
65                  70                  75                  80  
Val Asp Val Gln Gln Asn Asp Ser Ala Thr Tyr Thr Asn Val Ser Gly 
                85                  90                  95      
Asn Thr Ile Thr Glu Tyr Gln Arg Ser Leu Ala Val Ser Val Ala Ile 
            100                 105                 110         
Glu Gly Arg Tyr Asn Phe Phe Ser Gly Ser Leu Ser Thr Asp Phe Asp 
        115                 120                 125             
Ser Asn Ser Leu Arg Asn Ala Glu Asn Glu Phe Thr Arg Ile Gln Gln 
    130                 135                 140                 
Ser Ile Asn Leu Trp Ser Leu Arg Leu Pro Ser Val Lys Ser Leu Arg 
145                 150                 155                 160 
Asp Leu Met Leu Pro His Met Arg Glu Gln Leu Asp Glu Leu Asp Val 
                165                 170                 175     
Lys Asn Pro Ser Ala Ile Ser Arg Phe Phe Asp Arg Val Gly Ser His 
            180                 185                 190         
Phe Leu Thr Gly Ile Val Met Gly Gly Arg Ala Ile Leu Ala Ser Ser 
        195                 200                 205             
Thr Asn Lys Leu Arg Val Lys Arg Asp Tyr Ser Val Ser Val Val Ala 
    210                 215                 220                 
Lys Ala Ser Tyr Glu Gly Leu Thr Gly Gln Leu Ser Ala Glu Ala Lys 
225                 230                 235                 240 
Ala Lys Tyr Gly Glu Ser Ile Ser Ser Phe Thr Gln Tyr Ser Asn Thr 
                245                 250                 255     
His Gln Glu Val Arg Gly Gly Asp Gly Thr Lys Ala His Gly Val Phe 
            260                 265                 270         
Glu Gly Lys Ala Gly Phe Gln Ala Trp Val Asp Ser Val Gly Thr Ser 
        275                 280                 285             
Pro Asp Phe Val Asp Phe Val Pro Thr Ile Pro Met Leu Glu Ile Trp 
    290                 295                 300                 
Ser Leu Cys Lys Thr Asp Ser Gln Ala Glu Ala Met Lys Arg His Phe 
305                 310                 315                 320 
Asp Thr Val Trp Ala Arg Glu Gln Ser Asp Lys Tyr Arg Ile Lys Ala 
                325                 330                 335     
Asn Tyr Ile Asp Gln Leu Val Val Ile Thr Gly Asp Ser Ser Thr Ile 
            340                 345                 350         
Glu Pro Pro Ala Gly Tyr Thr Lys Ile Pro Tyr Asp Leu Asn Ala Gly 
        355                 360                 365             
Ala Lys Gly Asp Phe Ile Tyr Leu Cys Tyr His Glu Gln Thr Trp Gln 
    370                 375                 380                 
Ala Asp Arg Pro Lys Asp Ala Val Thr Asp Ile Arg Ile Ile Phe Asn 
385                 390                 395                 400 
Lys Glu Pro Thr Pro Pro Gly Tyr Thr Lys Leu Pro Gln Asp Leu Asn 
                405                 410                 415     
Lys Gly Ala Gly Gly Asp Asp Val Phe Leu Cys Tyr Lys Thr Glu Ala 
            420                 425                 430         
Tyr Asn Thr Asp Thr Ala Ile Asn Lys Val Thr Val Ile Gly Gly Asn 
        435                 440                 445             
Asn Ala Asp Ile Asn Ala Pro Tyr Gly Tyr Glu Lys Val Pro Gly Asp 
    450                 455                 460                 
Leu Asn Lys Gly Ala Lys Gly Asn Phe Ile Tyr Ala Cys Thr Phe Val 
465                 470                 475                 480 
Gly Lys 
        

<210>  191
<211>  482
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  191
Met Glu Asn Ile Asp Leu Pro Gln Gly Leu Val Asn Phe Ser Thr Gln 
1               5                   10                  15      
His Leu Gln Leu Ile Arg Phe Lys Ala Gly Leu Asn Glu Thr Val Leu 
            20                  25                  30          
Pro Gly Val Glu Ala Ile Gly Leu Gly Tyr Asn Pro Phe Ile Ser Tyr 
        35                  40                  45              
Ala Ser Val Asn Ser Gly Ala Val Gln Leu Phe Asp Trp Ala Thr Ala 
    50                  55                  60                  
Lys Lys Arg Glu Val Pro Phe Lys Ala Gly Tyr Phe Val Pro Glu Ile 
65                  70                  75                  80  
Val Asp Val Gln Gln Asn Asp Ser Ala Thr Tyr Thr Asn Val Ser Gly 
                85                  90                  95      
Asn Thr Ile Ser Glu Tyr Gln Arg Ser Leu Ala Thr Ser Val Ala Ile 
            100                 105                 110         
Glu Gly Arg Tyr Asn Phe Phe Ser Gly Ser Leu Ser Thr Asp Tyr Asp 
        115                 120                 125             
Glu Asn Ser Leu Arg Asn Ala Glu Asn Glu Phe Thr Arg Ile Gln Gln 
    130                 135                 140                 
Ser Ile Asn Leu Trp Ser Leu Arg Leu Pro Ser Val Lys Ser Leu Arg 
145                 150                 155                 160 
Asp Leu Met Leu Pro His Met Arg Glu Gln Leu Asp Glu Leu Asp Val 
                165                 170                 175     
Lys Asn Pro Ser Ala Ile Ser Arg Phe Phe Asp Arg Val Gly Ser His 
            180                 185                 190         
Phe Leu Thr Gly Ile Val Met Gly Gly Arg Ala Ile Leu Ala Ala Ser 
        195                 200                 205             
Thr Asn Lys Leu Lys Val Lys Arg Asp Tyr Ser Val Ser Val Ile Ala 
    210                 215                 220                 
Lys Ala Ser Tyr Glu Gly Leu Thr Gly Gln Leu Ser Ala Glu Ala Arg 
225                 230                 235                 240 
Thr Lys Tyr Gly Glu Ser Met Ser Ser Phe Thr Gln Tyr Ser Ser Thr 
                245                 250                 255     
His Gln Glu Val Arg Gly Gly Asp Gly Thr Lys Ala His Gly Val Phe 
            260                 265                 270         
Glu Gly Lys Ala Gly Phe Gln Ala Trp Val Asp Ser Val Gly Thr Ser 
        275                 280                 285             
Pro Asp Phe Val Asp Phe Val Pro Thr Ile Pro Met Leu Glu Ile Trp 
    290                 295                 300                 
Ser Leu Cys Lys Thr Asp Ser Gln Ala Glu Ala Met Lys Arg His Phe 
305                 310                 315                 320 
Asp Thr Val Trp Ala Arg Glu Gln Ser Asp Lys Tyr Arg Ile Lys Ala 
                325                 330                 335     
Asn Tyr Ile Asp Gln Leu Val Val Ile Thr Gly Asp Ser Ser Thr Ile 
            340                 345                 350         
Glu Pro Pro Ala Gly Tyr Thr Lys Ile Pro Tyr Asp Leu Asn Ala Ser 
        355                 360                 365             
Ala Gly Gly Asp Phe Ile Tyr Leu Cys Tyr His Glu Gln Thr Trp Gln 
    370                 375                 380                 
Ala Asp Arg Pro Lys Asp Ala Val Thr Asp Ile Arg Ile Ile Phe Asn 
385                 390                 395                 400 
Lys Glu Pro Thr Pro Pro Gly Tyr Thr Lys Leu Pro Gln Asp Leu Asn 
                405                 410                 415     
Lys Gly Ala Gly Gly Asp Asp Val Phe Leu Cys Tyr Lys Thr Glu Ala 
            420                 425                 430         
Tyr Asn Thr Asp Thr Ala Ile Asn Lys Val Thr Val Ile Gly Gly Asn 
        435                 440                 445             
Asn Ala Asp Ile Asn Ala Pro Tyr Gly Tyr Leu Lys Val Pro Gly Asp 
    450                 455                 460                 
Leu Asn Arg Gly Ala Gly Gly Asn Phe Ile Tyr Ala Cys Thr Phe Val 
465                 470                 475                 480 
Gly Lys 
        

<210>  192
<211>  483
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  192
Met Glu Asn Ile Asp Leu Pro Gln Gly Leu Val Asn Phe Ser Thr Gln 
1               5                   10                  15      
His Leu Gln Leu Ile Arg Phe Lys Ala Gly Leu Asn Glu Thr Val Leu 
            20                  25                  30          
Pro Gly Val Glu Ala Ile Gly Leu Gly Tyr Asn Pro Phe Ile Ser Tyr 
        35                  40                  45              
Ala Ser Val Asn Ser Gly Ala Val Gln Leu Phe Asp Trp Ala Thr Ala 
    50                  55                  60                  
Lys Lys Arg Glu Val Pro Phe Lys Ala Gly Tyr Phe Val Pro Glu Ile 
65                  70                  75                  80  
Val Asp Val Gln Gln Asn Asp Ser Ala Thr Tyr Thr Asn Val Ser Gly 
                85                  90                  95      
Asn Thr Ile Ser Glu Tyr Gln Arg Ser Leu Ala Thr Ser Val Ala Ile 
            100                 105                 110         
Glu Gly Arg Tyr Asn Phe Phe Ser Gly Ser Leu Ser Thr Asp Phe Asp 
        115                 120                 125             
Ser Asn Ser Leu Arg Asn Ala Glu Asn Glu Phe Thr Arg Ile Gln Gln 
    130                 135                 140                 
Ser Ile Asn Leu Trp Ser Leu Arg Leu Pro Ser Val Lys Ser Leu Arg 
145                 150                 155                 160 
Glu Leu Met Leu Pro His Met Arg Glu Gln Leu Asp Glu Leu Asn Val 
                165                 170                 175     
Asn Asp Pro Lys Ala Ile Ser Arg Tyr Phe Asp Arg Val Gly Ser His 
            180                 185                 190         
Phe Leu Thr Gly Ile Val Met Gly Gly Arg Ala Ile Leu Ala Ser Ser 
        195                 200                 205             
Thr Asn Lys Leu Lys Val Lys Arg Asp Tyr Ser Val Ser Val Val Ala 
    210                 215                 220                 
Lys Ala Ser Tyr Glu Gly Leu Thr Gly Gln Leu Ser Ala Glu Ala Lys 
225                 230                 235                 240 
Ala Lys Tyr Gly Glu Ser Ile Ser Ser Phe Thr Gln Tyr Ser Asn Thr 
                245                 250                 255     
His Gln Glu Val Arg Gly Gly Asp Gly Ala Lys Ala His Gly Val Phe 
            260                 265                 270         
Ser Gly Lys Lys Glu Asp Phe Gln Ala Trp Val Asp Ser Val Ser Ala 
        275                 280                 285             
Ser Pro Asp Phe Val Asp Phe Val Pro Thr Ile Pro Met Gln Glu Ile 
    290                 295                 300                 
Trp Thr Leu Cys Ser Ser Glu Ala Gln Ala Glu Ala Met Arg Lys His 
305                 310                 315                 320 
Tyr Asp Asp Val Trp Ala Pro Ala Gln Ser Glu Lys Tyr Arg Val Lys 
                325                 330                 335     
Ala Asn Tyr Ile Asp Gln Leu Val Val Ile Thr Gly Asp Ser Ser Thr 
            340                 345                 350         
Ile Glu Pro Pro Ala Gly Tyr Thr Lys Ile Pro Tyr Asp Leu Asn Ala 
        355                 360                 365             
Gly Ala Gly Gly Asp Phe Ile Tyr Leu Cys Tyr His Glu Gln Ala Trp 
    370                 375                 380                 
Tyr Pro Asp Asn Thr Lys Pro Ala Val Thr Ala Ile Lys Ile Ile Tyr 
385                 390                 395                 400 
Asp Arg Glu Pro Val Pro Thr Gly Tyr Ile Lys Leu Pro Gln Asp Leu 
                405                 410                 415     
Asn Lys Gly Ala Gly Gly Ala Asp Ile Tyr Leu Cys Tyr Lys Leu Glu 
            420                 425                 430         
Gly Tyr Asn Thr Asp Thr Ala Ile Asn Lys Ile Thr Val Ile Ser Gly 
        435                 440                 445             
Asn Asn Pro Asp Ile Asn Ala Pro Tyr Gly Tyr Glu Lys Val Pro Gly 
    450                 455                 460                 
Asp Leu Asn Lys Gly Ala Gly Gly Asn Phe Ile Tyr Ala Cys Thr Phe 
465                 470                 475                 480 
Val Gly Lys 
            

<210>  193
<211>  484
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  193
Met Glu His Val Asp Leu Pro Thr Gly Leu Val Lys Phe Ser Ser Asn 
1               5                   10                  15      
His His Leu Gln Leu Leu Arg Asp Thr Ala Asp Leu Ser Glu Ser Val 
            20                  25                  30          
Leu Pro Gly Val Glu Ala Ile Gly Leu Gly Tyr Asn Pro Phe Ile Ser 
        35                  40                  45              
Tyr Ala Ser Val Asn Ser Gly Ala Val Gln Leu Phe Asp Trp Ala Thr 
    50                  55                  60                  
Ala Lys Lys Arg Glu Val Pro Phe Lys Ala Gly Tyr Phe Val Pro Glu 
65                  70                  75                  80  
Ile Val Asp Val Gln Gln Asn Asp Ser Ala Ser Tyr Thr Asn Ile Ser 
                85                  90                  95      
Gly Asn Thr Ile Ser Glu Tyr Gln Arg Ser Leu Ala Val Ser Val Ala 
            100                 105                 110         
Ile Glu Gly Lys Tyr Asn Phe Phe Ser Gly Ser Leu Ser Thr Asp Tyr 
        115                 120                 125             
Asp Glu Asn Ser Leu Arg Asn Ala Glu Asn Glu Phe Thr Arg Ile Gln 
    130                 135                 140                 
Gln Ser Ile Asn Leu Trp Ser Leu Arg Leu Pro Ser Val Lys Ser Leu 
145                 150                 155                 160 
Arg Asp Leu Met Leu Pro His Met Arg Glu Gln Leu Asp Glu Leu Asp 
                165                 170                 175     
Val Lys Asn Pro Ser Ala Ile Ser Arg Phe Phe Asp Arg Val Gly Ser 
            180                 185                 190         
His Phe Leu Thr Gly Ile Val Met Gly Gly Arg Ala Ile Leu Ala Ala 
        195                 200                 205             
Ser Thr Asn Lys Leu Lys Val Lys Arg Asp Tyr Ser Val Ser Val Ile 
    210                 215                 220                 
Ala Lys Ala Ser Tyr Glu Gly Leu Thr Gly Gln Leu Ser Ala Glu Ala 
225                 230                 235                 240 
Arg Thr Lys Tyr Gly Glu Ser Met Ser Ser Phe Thr Gln Tyr Ser Ser 
                245                 250                 255     
Thr His Gln Glu Val Arg Gly Gly Asp Gly Ala Lys Ala His Gly Val 
            260                 265                 270         
Phe Ser Gly Lys Lys Glu Asp Phe Gln Ala Trp Val Asp Ser Val Ser 
        275                 280                 285             
Ala Ser Pro Asp Phe Val Asp Phe Val Pro Thr Ile Pro Met Leu Glu 
    290                 295                 300                 
Ile Trp Ser Leu Cys Lys Thr Asp Ser Gln Ala Glu Ala Met Lys Arg 
305                 310                 315                 320 
His Phe Asp Thr Val Trp Ala Arg Glu Gln Ser Asp Lys Tyr Arg Ile 
                325                 330                 335     
Lys Ala Asn Tyr Ile Asp Gln Leu Val Val Ile Thr Gly Asp Ser Ser 
            340                 345                 350         
Thr Ile Glu Pro Pro Ala Gly Tyr Thr Lys Ile Pro Tyr Asp Leu Asn 
        355                 360                 365             
Ala Gly Ala Lys Gly Asp Phe Ile Tyr Leu Cys Tyr His Glu Gln Thr 
    370                 375                 380                 
Trp Gln Ala Asp Arg Pro Lys Asp Ala Val Thr Asp Ile Arg Ile Ile 
385                 390                 395                 400 
Phe Asn Lys Glu Pro Thr Pro Pro Gly Tyr Thr Lys Leu Pro Gln Asp 
                405                 410                 415     
Leu Asn Lys Gly Ala Gly Gly Asp Asp Val Phe Leu Cys Tyr Lys Thr 
            420                 425                 430         
Glu Ala Tyr Asn Thr Asp Thr Ala Ile Asn Lys Ile Thr Val Ile Ser 
        435                 440                 445             
Gly Asn Asn Pro Asp Ile Asn Ala Pro Tyr Gly Tyr Glu Lys Val Pro 
    450                 455                 460                 
Gly Asp Leu Asn Lys Gly Ala Lys Gly Asn Phe Ile Tyr Ala Cys Thr 
465                 470                 475                 480 
Phe Val Gly Lys 
                

<210>  194
<211>  483
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  194
Met Glu Asn Ile Asp Leu Pro Gln Gly Leu Val Asn Phe Ser Thr Gln 
1               5                   10                  15      
His Leu Gln Leu Ile Arg Phe Lys Ala Gly Leu Asn Glu Thr Val Leu 
            20                  25                  30          
Pro Gly Val Glu Ala Ile Gly Leu Gly Tyr Asn Pro Phe Ile Ser Tyr 
        35                  40                  45              
Ala Ser Val Asn Ser Gly Ala Val Gln Leu Phe Asp Trp Ala Thr Ala 
    50                  55                  60                  
Lys Lys Arg Glu Val Pro Phe Lys Ala Gly Tyr Phe Val Pro Glu Ile 
65                  70                  75                  80  
Val Asp Val Gln Gln Asn Asp Ser Ala Thr Tyr Thr Asn Val Ser Gly 
                85                  90                  95      
Asn Thr Ile Ser Glu Tyr Gln Arg Ser Leu Ala Thr Ser Val Ala Ile 
            100                 105                 110         
Glu Gly Arg Tyr Asn Phe Phe Ser Gly Ser Leu Ser Thr Asp Phe Asp 
        115                 120                 125             
Ser Asn Ser Leu Arg Asn Ala Glu Asn Glu Phe Thr Arg Ile Gln Gln 
    130                 135                 140                 
Ser Ile Asn Leu Trp Ser Leu Arg Leu Pro Ser Val Lys Ser Leu Arg 
145                 150                 155                 160 
Asp Leu Met Leu Pro His Met Arg Glu Gln Leu Asp Glu Leu Asn Val 
                165                 170                 175     
Asn Asp Pro Lys Ala Ile Ser Arg Tyr Phe Asp Arg Val Gly Ser His 
            180                 185                 190         
Phe Leu Thr Gly Ile Val Met Gly Gly Arg Ala Ile Leu Ala Ser Ser 
        195                 200                 205             
Thr Asn Lys Leu Arg Val Lys Arg Asp Tyr Ser Val Ser Val Val Ala 
    210                 215                 220                 
Lys Ala Ser Tyr Glu Gly Leu Thr Gly Gln Leu Ser Ala Glu Ala Lys 
225                 230                 235                 240 
Ala Lys Tyr Gly Glu Ser Ile Ser Ser Phe Thr Gln Tyr Ser Asn Thr 
                245                 250                 255     
His Gln Glu Val Arg Gly Gly Asp Gly Ala Lys Ala His Gly Val Phe 
            260                 265                 270         
Ser Gly Lys Lys Glu Asp Phe Gln Ala Trp Val Asp Ser Val Ser Ala 
        275                 280                 285             
Ser Pro Asp Phe Val Asp Phe Val Pro Thr Ile Pro Met Gln Glu Ile 
    290                 295                 300                 
Trp Thr Leu Cys Ser Ser Glu Ala Gln Ala Glu Ala Met Arg Lys His 
305                 310                 315                 320 
Tyr Asp Asp Val Trp Ala Pro Ala Gln Ser Glu Lys Tyr Arg Val Lys 
                325                 330                 335     
Ala Asn Tyr Ile Asp Gln Leu Val Val Ile Thr Gly Gly Ser Ser Thr 
            340                 345                 350         
Ile Glu Pro Pro Ala Gly Tyr Thr Lys Ile Pro Tyr Asp Leu Asn Ala 
        355                 360                 365             
Gly Ala Lys Gly Asp Phe Ile Tyr Leu Cys Tyr His Glu Gln Ala Trp 
    370                 375                 380                 
Tyr Pro Asp Asn Thr Lys Pro Ala Val Thr Ala Ile Lys Ile Ile Tyr 
385                 390                 395                 400 
Asp Arg Glu Pro Val Pro Thr Gly Tyr Ile Lys Leu Pro Gln Asp Leu 
                405                 410                 415     
Asn Lys Gly Ala Gly Gly Ala Asp Ile Tyr Leu Cys Tyr Lys Leu Glu 
            420                 425                 430         
Gly Tyr Asn Thr Asp Thr Ala Ile Asn Lys Ile Thr Val Ile Ser Gly 
        435                 440                 445             
Asn Asn Pro Asp Ile Asn Ala Pro Tyr Gly Tyr Glu Lys Val Pro Gly 
    450                 455                 460                 
Asp Leu Asn Lys Gly Ala Lys Gly Asn Phe Ile Tyr Ala Cys Thr Phe 
465                 470                 475                 480 
Val Gly Lys 
            

<210>  195
<211>  484
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  195
Met Glu His Val Asp Leu Pro Thr Gly Leu Val Lys Phe Ser Ser Asn 
1               5                   10                  15      
His His Leu Gln Leu Leu Arg Asp Thr Ala Asp Leu Ser Glu Ser Val 
            20                  25                  30          
Leu Pro Gly Val Glu Ala Ile Gly Leu Gly Tyr Asn Pro Phe Leu Gly 
        35                  40                  45              
Tyr Ala Gly Val Gly Ser Gly Thr Val Gln Leu Phe Asp Trp Asn Asn 
    50                  55                  60                  
Ala Lys Lys Lys Lys Val Ser Phe Lys Pro Glu Phe Val Val Pro Glu 
65                  70                  75                  80  
Ile Val Asp Val Gln Gln Asn Asp Ser Ala Ser Tyr Thr Asn Ile Ser 
                85                  90                  95      
Gly Asn Thr Val Thr Glu Tyr Gln Arg Ser Leu Ala Val Ser Val Ala 
            100                 105                 110         
Ile Glu Gly Lys Tyr Asn Phe Phe Ser Gly Ser Leu Ser Thr Asp Tyr 
        115                 120                 125             
Asp Glu Asn Ser Leu Arg Asn Ala Glu Asn Glu Phe Thr Arg Ile Gln 
    130                 135                 140                 
Gln Ser Ile Asn Leu Trp Ser Leu Arg Leu Pro Ser Val Lys Ser Leu 
145                 150                 155                 160 
Arg Asp Leu Met Leu Pro His Met Arg Gln Gln Leu Asp Glu Leu Asn 
                165                 170                 175     
Val Asn Asp Pro Lys Ala Ile Ser Arg Tyr Phe Asp Arg Val Gly Ser 
            180                 185                 190         
His Phe Leu Thr Gly Ile Val Met Gly Gly Arg Ala Ile Leu Ala Ser 
        195                 200                 205             
Ser Thr Asn Lys Leu Arg Val Lys Arg Asp Tyr Ser Val Ser Val Val 
    210                 215                 220                 
Ala Lys Ala Ser Tyr Glu Gly Leu Thr Gly Gln Leu Ser Ala Glu Ala 
225                 230                 235                 240 
Lys Ala Lys Tyr Gly Glu Ser Ile Ser Ser Phe Thr Gln Tyr Ser Asn 
                245                 250                 255     
Thr His Gln Glu Val Arg Gly Gly Asp Gly Ala Lys Ala His Gly Val 
            260                 265                 270         
Phe Ser Gly Lys Lys Glu Asp Phe Gln Ala Trp Val Asp Ser Val Ser 
        275                 280                 285             
Ala Ser Pro Asp Phe Val Asp Phe Val Pro Thr Ile Pro Met Leu Glu 
    290                 295                 300                 
Ile Trp Thr Leu Cys Ser Ser Glu Ala Gln Ala Glu Ala Met Arg Lys 
305                 310                 315                 320 
His Tyr Asp Asp Val Trp Ala Pro Ala Gln Ser Glu Lys Tyr Arg Val 
                325                 330                 335     
Lys Ala Asn Tyr Ile Asp Gln Leu Val Val Ile Thr Gly Gly Ser Ser 
            340                 345                 350         
Thr Ile Glu Pro Pro Val Gly Tyr Ser Lys Ile Glu Tyr Asp Leu Asn 
        355                 360                 365             
Ala Gly Ala Gly Gly Asp Phe Ile Tyr Leu Cys Tyr His Glu Gln Ala 
    370                 375                 380                 
Trp Tyr Pro Asp Asn Thr Lys Pro Ala Val Thr Ala Ile Lys Ile Ile 
385                 390                 395                 400 
Tyr Asp Arg Glu Pro Val Pro Thr Gly Tyr Ile Lys Leu Pro Gln Asp 
                405                 410                 415     
Leu Asn Lys Gly Ala Gly Gly Ala Asp Ile Tyr Leu Cys Tyr Lys Leu 
            420                 425                 430         
Glu Gly Tyr Asn Thr Asp Thr Ala Ile Asn Lys Ile Met Val Ile Ser 
        435                 440                 445             
Gly Asn Asn Pro Asp Ile Asn Ala Pro Tyr Gly Tyr Glu Lys Val Pro 
    450                 455                 460                 
Gly Asp Leu Asn Arg Gly Ala Gly Gly Asn Phe Ile Tyr Ala Cys Thr 
465                 470                 475                 480 
Phe Val Gly Lys 
                

<210>  196
<211>  484
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  196
Met Glu His Val Asp Leu Pro Thr Gly Leu Val Lys Phe Ser Ser Asn 
1               5                   10                  15      
His His Leu Gln Leu Leu Arg Asp Thr Ala Asp Leu Ser Glu Ser Val 
            20                  25                  30          
Leu Pro Gly Val Glu Ala Ile Gly Leu Gly Tyr Asn Pro Phe Leu Gly 
        35                  40                  45              
Tyr Ala Gly Val Gly Ser Gly Thr Val Gln Leu Phe Asp Trp Asn Asn 
    50                  55                  60                  
Ala Lys Lys Lys Lys Val Ser Phe Lys Pro Glu Phe Val Val Pro Glu 
65                  70                  75                  80  
Ile Val Asp Val Gln Gln Asn Asp Ser Ala Ser Tyr Thr Asn Ile Ser 
                85                  90                  95      
Gly Asn Thr Val Thr Glu Tyr Gln Arg Ser Leu Ala Val Ser Val Ala 
            100                 105                 110         
Ile Glu Gly Arg Tyr Asn Phe Phe Ser Gly Ser Leu Ser Thr Asp Phe 
        115                 120                 125             
Asp Ser Asn Ser Leu Arg Asn Ala Glu Asn Glu Phe Thr Arg Ile Gln 
    130                 135                 140                 
Gln Ser Ile Asn Leu Trp Ser Leu Arg Leu Pro Ser Val Lys Ser Leu 
145                 150                 155                 160 
Arg Glu Leu Met Leu Pro His Met Arg Gln Gln Leu Asp Glu Leu Asn 
                165                 170                 175     
Val Asn Asp Pro Lys Ala Ile Ser Arg Tyr Phe Asp Arg Val Gly Ser 
            180                 185                 190         
His Phe Leu Thr Gly Ile Val Met Gly Gly Arg Ala Ile Leu Ala Ser 
        195                 200                 205             
Ser Thr Asn Lys Leu Lys Val Lys Arg Asp Tyr Ser Val Ser Val Ile 
    210                 215                 220                 
Ala Lys Ala Ser Tyr Glu Gly Leu Thr Gly Gln Leu Ser Ala Glu Ala 
225                 230                 235                 240 
Lys Ala Lys Tyr Gly Glu Ser Ile Ser Ser Phe Thr Gln Tyr Ser Asn 
                245                 250                 255     
Thr His Gln Glu Val Arg Gly Gly Asp Gly Ala Lys Ala His Gly Val 
            260                 265                 270         
Phe Ser Gly Lys Lys Glu Asp Phe Gln Ala Trp Val Asp Ser Val Ser 
        275                 280                 285             
Ala Ser Pro Asp Phe Val Asp Phe Val Pro Thr Ile Pro Met Gln Glu 
    290                 295                 300                 
Ile Trp Thr Leu Cys Ser Ser Glu Ala Gln Ala Glu Ala Met Arg Lys 
305                 310                 315                 320 
His Tyr Asp Asp Val Trp Ala Pro Ala Gln Ser Glu Lys Tyr Arg Val 
                325                 330                 335     
Lys Ala Asn Tyr Ile Asp Gln Leu Val Val Ile Thr Gly Asp Ser Ser 
            340                 345                 350         
Thr Ile Glu Pro Pro Ala Gly Tyr Thr Lys Ile Pro Tyr Asp Leu Asn 
        355                 360                 365             
Ala Gly Ala Lys Gly Asp Phe Ile Tyr Leu Cys Tyr His Glu Gln Ala 
    370                 375                 380                 
Trp Tyr Pro Asp Asn Thr Lys Pro Ala Val Thr Ala Ile Lys Ile Ile 
385                 390                 395                 400 
Tyr Asp Arg Glu Pro Val Pro Thr Gly Tyr Ile Lys Leu Pro Gln Asp 
                405                 410                 415     
Leu Asn Lys Gly Ala Gly Gly Ala Asp Ile Tyr Leu Cys Tyr Lys Leu 
            420                 425                 430         
Glu Gly Tyr Asn Thr Asp Thr Ala Ile Asn Lys Ile Thr Val Ile Ser 
        435                 440                 445             
Gly Asn Asn Pro Asp Ile Asn Ala Pro Tyr Gly Tyr Leu Lys Val Pro 
    450                 455                 460                 
Gly Asp Leu Asn Arg Gly Ala Gly Gly Asn Phe Ile Tyr Ala Cys Thr 
465                 470                 475                 480 
Phe Val Gly Lys 
                

<210>  197
<211>  482
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  197
Met Glu Asn Ile Asp Leu Pro Gln Gly Leu Val Asn Phe Ser Thr Gln 
1               5                   10                  15      
His Leu Gln Leu Ile Arg Phe Lys Ala Gly Leu Asn Glu Thr Val Leu 
            20                  25                  30          
Pro Gly Val Glu Ala Ile Gly Leu Gly Tyr Asn Pro Phe Ile Ser Tyr 
        35                  40                  45              
Ala Ser Val Asn Ser Gly Ala Val Gln Leu Phe Asp Trp Ala Thr Ala 
    50                  55                  60                  
Lys Lys Arg Glu Val Pro Phe Lys Ala Gly Tyr Phe Val Pro Glu Ile 
65                  70                  75                  80  
Val Asp Val Gln Gln Asn Asp Ser Ala Ser Tyr Thr Asn Ile Ser Gly 
                85                  90                  95      
Asn Thr Val Thr Glu Tyr Gln Arg Ser Leu Ala Val Ser Val Ala Ile 
            100                 105                 110         
Glu Gly Lys Tyr Asn Phe Phe Ser Gly Ser Leu Ser Thr Asp Tyr Asp 
        115                 120                 125             
Glu Asn Ser Leu Arg Asn Ala Glu Asn Glu Phe Thr Arg Ile Gln Gln 
    130                 135                 140                 
Ser Ile Asn Leu Trp Ser Leu Arg Leu Pro Ser Val Lys Ser Leu Arg 
145                 150                 155                 160 
Asp Leu Met Leu Pro His Met Arg Glu Gln Leu Asp Glu Leu Asp Val 
                165                 170                 175     
Lys Asn Pro Ser Ala Ile Ser Arg Phe Phe Asp Arg Val Gly Ser His 
            180                 185                 190         
Phe Leu Thr Gly Ile Val Met Gly Gly Arg Ala Ile Leu Ala Ser Ser 
        195                 200                 205             
Thr Asn Lys Leu Arg Val Lys Arg Asp Tyr Ser Val Ser Val Val Ala 
    210                 215                 220                 
Lys Ala Ser Tyr Glu Gly Leu Thr Gly Gln Leu Ser Ala Glu Ala Arg 
225                 230                 235                 240 
Thr Lys Tyr Gly Glu Ser Met Ser Ser Phe Thr Gln Tyr Ser Ser Thr 
                245                 250                 255     
His Gln Glu Val Arg Gly Gly Asp Gly Thr Lys Ala His Gly Val Phe 
            260                 265                 270         
Glu Gly Lys Ala Gly Phe Gln Ala Trp Val Asp Ser Val Gly Thr Ser 
        275                 280                 285             
Pro Asp Phe Val Asp Phe Val Pro Thr Ile Pro Met Gln Glu Ile Trp 
    290                 295                 300                 
Thr Leu Cys Ser Ser Glu Ala Gln Ala Glu Ala Met Arg Lys His Tyr 
305                 310                 315                 320 
Asp Asp Val Trp Ala Pro Ala Gln Ser Glu Lys Tyr Arg Val Lys Ala 
                325                 330                 335     
Asn Tyr Ile Asp Gln Leu Val Val Ile Thr Gly Asp Ser Ser Thr Ile 
            340                 345                 350         
Glu Pro Pro Val Gly Tyr Ser Lys Ile Pro Tyr Asp Leu Asn Ala Gly 
        355                 360                 365             
Ala Lys Gly Asp Phe Ile Tyr Leu Cys Tyr His Glu Gln Ala Trp Tyr 
    370                 375                 380                 
Pro Asp Asn Thr Lys Pro Ala Val Thr Ala Ile Lys Ile Ile Tyr Asp 
385                 390                 395                 400 
Arg Glu Pro Val Pro Thr Gly Tyr Ile Lys Leu Pro Gln Asp Leu Asn 
                405                 410                 415     
Lys Gly Ala Gly Gly Asp Asp Val Phe Leu Cys Tyr Lys Thr Glu Ala 
            420                 425                 430         
Tyr Asn Thr Asp Thr Ala Ile Asn Lys Val Thr Val Ile Gly Gly Asn 
        435                 440                 445             
Asn Ala Asp Ile Asn Ala Pro Tyr Gly Tyr Leu Lys Val Pro Gly Asp 
    450                 455                 460                 
Leu Asn Arg Gly Ala Gly Gly Asn Phe Ile Tyr Ala Cys Thr Phe Val 
465                 470                 475                 480 
Gly Lys 
        

<210>  198
<211>  483
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  198
Met Glu Asn Ile Asp Leu Pro Gln Gly Leu Val Asn Phe Ser Thr Gln 
1               5                   10                  15      
His Leu Gln Leu Ile Arg Phe Lys Ala Gly Leu Asn Glu Thr Val Leu 
            20                  25                  30          
Pro Gly Val Glu Ala Ile Gly Leu Gly Tyr Asn Pro Phe Ile Ser Tyr 
        35                  40                  45              
Ala Ser Val Asn Ser Gly Ala Val Gln Leu Phe Asp Trp Ala Thr Ala 
    50                  55                  60                  
Lys Lys Arg Glu Val Pro Phe Lys Ala Gly Tyr Phe Val Pro Glu Ile 
65                  70                  75                  80  
Val Asp Val Gln Gln Asn Asp Ser Ala Thr Tyr Thr Asn Val Ser Gly 
                85                  90                  95      
Asn Thr Ile Ser Glu Tyr Gln Arg Ser Leu Ala Thr Ser Val Ala Ile 
            100                 105                 110         
Glu Gly Arg Tyr Asn Phe Phe Ser Gly Ser Leu Ser Thr Asp Tyr Asp 
        115                 120                 125             
Glu Asn Ser Leu Arg Asn Ala Glu Asn Glu Phe Thr Arg Ile Gln Gln 
    130                 135                 140                 
Ser Ile Asn Leu Trp Ser Leu Arg Leu Pro Ser Val Lys Ser Leu Arg 
145                 150                 155                 160 
Glu Leu Met Leu Pro His Met Arg Gln Gln Leu Asp Glu Leu Asn Val 
                165                 170                 175     
Asn Asp Pro Lys Ala Ile Ser Arg Tyr Phe Asp Arg Val Gly Ser His 
            180                 185                 190         
Phe Leu Thr Gly Ile Val Met Gly Gly Arg Ala Ile Leu Ala Ser Ser 
        195                 200                 205             
Thr Asn Lys Leu Arg Val Lys Arg Asp Tyr Ser Val Ser Val Val Ala 
    210                 215                 220                 
Lys Ala Ser Tyr Glu Gly Leu Thr Gly Gln Leu Ser Ala Glu Ala Arg 
225                 230                 235                 240 
Thr Lys Tyr Gly Glu Ser Met Ser Ser Phe Thr Gln Tyr Ser Ser Thr 
                245                 250                 255     
His Gln Glu Val Arg Gly Gly Asp Gly Ala Lys Ala His Gly Val Phe 
            260                 265                 270         
Ser Gly Lys Lys Glu Asp Phe Gln Ala Trp Val Asp Ser Val Gly Thr 
        275                 280                 285             
Ser Pro Asp Phe Val Asp Phe Val Pro Thr Ile Pro Met Leu Glu Ile 
    290                 295                 300                 
Trp Ser Leu Cys Lys Thr Asp Ser Gln Ala Glu Ala Met Lys Arg His 
305                 310                 315                 320 
Phe Asp Thr Val Trp Ala Arg Glu Gln Ser Asp Lys Tyr Arg Ile Lys 
                325                 330                 335     
Ala Asn Tyr Ile Asp Gln Leu Val Val Ile Thr Gly Asp Ser Ser Thr 
            340                 345                 350         
Ile Glu Pro Pro Ala Gly Tyr Thr Lys Ile Pro Tyr Asp Leu Asn Ala 
        355                 360                 365             
Gly Ala Gly Gly Asp Phe Ile Tyr Leu Cys Tyr His Glu Gln Ala Trp 
    370                 375                 380                 
Tyr Pro Asp Asn Thr Lys Pro Ala Val Thr Ala Ile Lys Ile Ile Tyr 
385                 390                 395                 400 
Asp Arg Glu Pro Val Pro Thr Gly Tyr Ile Lys Leu Pro Gln Asp Leu 
                405                 410                 415     
Asn Lys Gly Ala Gly Gly Ala Asp Ile Tyr Leu Cys Tyr Lys Leu Glu 
            420                 425                 430         
Gly Tyr Asn Thr Asp Thr Ala Ile Asn Lys Ile Thr Val Ile Ser Gly 
        435                 440                 445             
Asn Asn Pro Asp Ile Asn Ala Pro Tyr Gly Tyr Glu Lys Val Pro Gly 
    450                 455                 460                 
Asp Leu Asn Lys Gly Ala Lys Gly Asn Phe Ile Tyr Ala Cys Thr Phe 
465                 470                 475                 480 
Val Gly Lys 
            

<210>  199
<211>  483
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  199
Met Glu His Val Asp Leu Pro Thr Gly Leu Val Lys Phe Ser Ser Asn 
1               5                   10                  15      
His His Leu Gln Leu Leu Arg Asp Thr Ala Asp Leu Ser Glu Ser Val 
            20                  25                  30          
Leu Pro Gly Val Glu Ala Ile Gly Leu Gly Tyr Asn Pro Phe Leu Gly 
        35                  40                  45              
Tyr Ala Gly Val Gly Ser Gly Thr Val Gln Leu Phe Asp Trp Asn Asn 
    50                  55                  60                  
Ala Lys Lys Lys Lys Val Ser Phe Lys Pro Glu Phe Val Val Pro Glu 
65                  70                  75                  80  
Ile Val Asp Val Gln Gln Asn Asp Ser Ala Thr Tyr Thr Asn Ile Ser 
                85                  90                  95      
Gly Asn Thr Val Thr Glu Tyr Gln Arg Ser Leu Ala Val Ser Val Ala 
            100                 105                 110         
Ile Glu Gly Arg Tyr Asn Phe Phe Ser Gly Ser Leu Ser Thr Asp Tyr 
        115                 120                 125             
Asp Glu Asn Ser Leu Arg Asn Ala Glu Asn Glu Phe Thr Arg Ile Gln 
    130                 135                 140                 
Gln Ser Ile Asn Leu Trp Ser Leu Arg Leu Pro Ser Val Lys Ser Leu 
145                 150                 155                 160 
Arg Glu Leu Met Leu Pro His Met Arg Gln Gln Leu Asp Glu Leu Asn 
                165                 170                 175     
Val Asn Asp Pro Lys Ala Ile Ser Arg Tyr Phe Asp Arg Val Gly Ser 
            180                 185                 190         
His Phe Leu Thr Gly Ile Val Met Gly Gly Arg Ala Ile Leu Ala Ala 
        195                 200                 205             
Ser Thr Asn Lys Leu Lys Val Lys Arg Asp Tyr Ser Val Ser Val Ile 
    210                 215                 220                 
Ala Lys Ala Ser Tyr Glu Gly Leu Thr Gly Gln Leu Ser Ala Glu Ala 
225                 230                 235                 240 
Arg Thr Lys Tyr Gly Glu Ser Met Ser Ser Phe Thr Gln Tyr Ser Ser 
                245                 250                 255     
Thr His Gln Glu Val Arg Gly Gly Asp Gly Thr Lys Ala His Gly Val 
            260                 265                 270         
Phe Glu Gly Lys Ala Gly Phe Gln Ala Trp Val Asp Ser Val Ser Ala 
        275                 280                 285             
Ser Pro Asp Phe Val Asp Phe Val Pro Thr Ile Pro Met Gln Glu Ile 
    290                 295                 300                 
Trp Thr Leu Cys Ser Ser Glu Ala Gln Ala Glu Ala Met Arg Lys His 
305                 310                 315                 320 
Tyr Asp Asp Val Trp Ala Pro Ala Gln Ser Glu Lys Tyr Arg Val Lys 
                325                 330                 335     
Ala Asn Tyr Ile Asp Gln Leu Val Val Ile Thr Gly Gly Ser Ser Thr 
            340                 345                 350         
Ile Glu Pro Pro Ala Gly Tyr Thr Lys Ile Pro Tyr Asp Leu Asn Ala 
        355                 360                 365             
Gly Ala Lys Gly Asp Phe Ile Tyr Leu Cys Tyr His Glu Gln Ala Trp 
    370                 375                 380                 
Tyr Pro Asp Asn Thr Lys Pro Ala Val Thr Ala Ile Lys Ile Ile Tyr 
385                 390                 395                 400 
Asp Arg Glu Pro Val Pro Thr Gly Tyr Ile Lys Leu Pro Gln Asp Leu 
                405                 410                 415     
Asn Lys Gly Ala Gly Gly Asp Asp Val Phe Leu Cys Tyr Lys Thr Glu 
            420                 425                 430         
Ala Tyr Asn Thr Asp Thr Ala Ile Asn Lys Val Thr Val Ile Gly Gly 
        435                 440                 445             
Asn Asn Ala Asp Ile Asn Ala Pro Tyr Gly Tyr Leu Lys Val Pro Gly 
    450                 455                 460                 
Asp Leu Asn Arg Gly Ala Gly Gly Asn Phe Ile Tyr Ala Cys Thr Phe 
465                 470                 475                 480 
Val Gly Lys 
            

<210>  200
<211>  483
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  200
Met Glu Asn Ile Asp Leu Pro Gln Gly Leu Val Asn Phe Ser Thr Gln 
1               5                   10                  15      
His Leu Gln Leu Ile Arg Phe Lys Ala Gly Leu Asn Glu Thr Val Leu 
            20                  25                  30          
Pro Gly Val Glu Ala Ile Gly Leu Gly Tyr Asn Pro Phe Ile Ser Tyr 
        35                  40                  45              
Ala Ser Val Asn Ser Gly Ala Val Gln Leu Phe Asp Trp Ala Thr Ala 
    50                  55                  60                  
Lys Lys Arg Glu Val Pro Phe Lys Ala Gly Tyr Phe Val Pro Glu Ile 
65                  70                  75                  80  
Val Asp Val Gln Gln Asn Asp Ser Ala Thr Tyr Thr Asn Val Ser Gly 
                85                  90                  95      
Asn Thr Ile Ser Glu Tyr Gln Arg Ser Leu Ala Thr Ser Val Ala Ile 
            100                 105                 110         
Glu Gly Arg Tyr Asn Phe Phe Ser Gly Ser Leu Ser Thr Asp Phe Asp 
        115                 120                 125             
Ser Asn Ser Leu Arg Asn Ala Glu Asn Glu Phe Thr Arg Ile Gln Gln 
    130                 135                 140                 
Ser Ile Asn Leu Trp Ser Leu Arg Leu Pro Ser Val Lys Ser Leu Arg 
145                 150                 155                 160 
Asp Leu Met Leu Pro His Met Arg Glu Gln Leu Asp Glu Leu Asp Val 
                165                 170                 175     
Lys Asn Pro Ser Ala Ile Ser Arg Phe Phe Asp Arg Val Gly Ser His 
            180                 185                 190         
Phe Leu Thr Gly Ile Val Met Gly Gly Arg Ala Ile Leu Ala Ala Ser 
        195                 200                 205             
Thr Asn Lys Leu Lys Val Lys Arg Asp Tyr Ser Val Ser Val Ile Ala 
    210                 215                 220                 
Lys Ala Ser Tyr Glu Gly Leu Thr Gly Gln Leu Ser Ala Glu Ala Lys 
225                 230                 235                 240 
Ala Lys Tyr Gly Glu Ser Ile Ser Ser Phe Thr Gln Tyr Ser Ser Thr 
                245                 250                 255     
His Gln Glu Val Arg Gly Gly Asp Gly Ala Lys Ala His Gly Val Phe 
            260                 265                 270         
Ser Gly Lys Lys Glu Asp Phe Gln Ala Trp Val Asp Ser Val Ser Ala 
        275                 280                 285             
Ser Pro Asp Phe Val Asp Phe Val Pro Thr Ile Pro Met Gln Glu Ile 
    290                 295                 300                 
Trp Thr Leu Cys Ser Ser Glu Ala Gln Ala Glu Ala Met Arg Lys His 
305                 310                 315                 320 
Tyr Asp Asp Val Trp Ala Pro Thr Gln Ser Glu Lys Tyr Arg Val Lys 
                325                 330                 335     
Ala Asn Tyr Ile Asp Gln Leu Val Val Ile Thr Gly Gly Ser Ser Thr 
            340                 345                 350         
Ile Glu Pro Pro Val Gly Tyr Ser Lys Ile Glu Tyr Asp Leu Asn Ala 
        355                 360                 365             
Gly Ala Lys Gly Asp Phe Ile Tyr Leu Cys Tyr His Glu Gln Ala Trp 
    370                 375                 380                 
Tyr Pro Asp Asn Thr Lys Pro Ala Val Thr Ala Ile Lys Ile Ile Tyr 
385                 390                 395                 400 
Asp Arg Glu Pro Val Pro Thr Gly Tyr Ile Lys Leu Pro Gln Asp Leu 
                405                 410                 415     
Asn Lys Gly Ala Gly Gly Ala Asp Ile Tyr Leu Cys Tyr Lys Leu Glu 
            420                 425                 430         
Gly Tyr Asn Thr Asp Thr Ala Ile Asn Lys Ile Thr Val Ile Ser Gly 
        435                 440                 445             
Asn Asn Pro Asp Ile Asn Ala Pro Tyr Gly Tyr Glu Lys Val Pro Gly 
    450                 455                 460                 
Asp Leu Asn Lys Gly Ala Lys Gly Asn Phe Ile Tyr Ala Cys Thr Phe 
465                 470                 475                 480 
Val Gly Lys 
            

<210>  201
<211>  483
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  201
Met Glu Asn Ile Asp Leu Pro Gln Gly Leu Val Asn Phe Ser Thr Gln 
1               5                   10                  15      
His Leu Gln Leu Ile Arg Phe Lys Ala Gly Leu Asn Glu Thr Val Leu 
            20                  25                  30          
Pro Gly Val Glu Ala Ile Gly Leu Gly Tyr Asn Pro Phe Ile Ser Tyr 
        35                  40                  45              
Ala Ser Val Asn Ser Gly Ala Val Gln Leu Phe Asp Trp Ala Thr Ala 
    50                  55                  60                  
Lys Lys Arg Glu Val Pro Phe Lys Ala Gly Tyr Phe Val Pro Glu Ile 
65                  70                  75                  80  
Val Asp Val Gln Gln Asn Asp Ser Ala Ser Tyr Thr Asn Ile Ser Gly 
                85                  90                  95      
Asn Thr Val Thr Glu Tyr Gln Arg Ser Leu Ala Val Ser Val Ala Ile 
            100                 105                 110         
Glu Gly Lys Tyr Asn Phe Phe Ser Gly Ser Leu Ser Thr Asp Tyr Asp 
        115                 120                 125             
Glu Asn Ser Leu Arg Asn Ala Glu Asn Glu Phe Thr Arg Ile Gln Gln 
    130                 135                 140                 
Ser Ile Asn Leu Trp Ser Leu Arg Leu Pro Ser Val Lys Ser Leu Arg 
145                 150                 155                 160 
Asp Leu Met Leu Pro His Met Arg Glu Gln Leu Asp Glu Leu Asp Val 
                165                 170                 175     
Lys Asn Pro Ser Ala Ile Ser Arg Phe Phe Asp Arg Val Gly Ser His 
            180                 185                 190         
Phe Leu Thr Gly Ile Val Met Gly Gly Arg Ala Ile Leu Ala Ala Ser 
        195                 200                 205             
Thr Asn Lys Leu Lys Val Lys Arg Asp Tyr Ser Val Ser Val Ile Ala 
    210                 215                 220                 
Lys Ala Ser Tyr Glu Gly Leu Thr Gly Gln Leu Ser Ala Glu Ala Lys 
225                 230                 235                 240 
Ala Lys Tyr Gly Glu Ser Ile Ser Ser Phe Thr Gln Tyr Ser Asn Thr 
                245                 250                 255     
His Gln Glu Val Arg Gly Gly Asp Gly Ala Lys Ala His Gly Val Phe 
            260                 265                 270         
Ser Gly Lys Lys Glu Asp Phe Gln Ala Trp Val Asp Ser Val Ser Ala 
        275                 280                 285             
Ser Pro Asp Phe Val Asp Phe Val Pro Thr Ile Pro Met Gln Glu Ile 
    290                 295                 300                 
Trp Thr Leu Cys Ser Ser Glu Ala Gln Ala Glu Ala Met Arg Lys His 
305                 310                 315                 320 
Tyr Asp Asp Val Trp Ala Pro Ala Gln Ser Glu Lys Tyr Arg Val Lys 
                325                 330                 335     
Ala Asn Tyr Ile Asp Gln Leu Val Val Ile Thr Gly Gly Ser Ser Thr 
            340                 345                 350         
Ile Glu Pro Pro Ala Gly Tyr Thr Lys Ile Pro Tyr Asp Leu Asn Ala 
        355                 360                 365             
Gly Ala Lys Gly Asp Phe Ile Tyr Leu Cys Tyr His Glu Gln Thr Trp 
    370                 375                 380                 
Gln Ala Asp Arg Pro Lys Asp Val Val Thr Asp Ile Arg Ile Ile Phe 
385                 390                 395                 400 
Asn Lys Glu Pro Thr Pro Pro Gly Tyr Thr Lys Leu Pro Gln Asp Leu 
                405                 410                 415     
Asn Lys Gly Ala Gly Gly Asp Asp Val Phe Leu Cys Tyr Lys Thr Glu 
            420                 425                 430         
Ala Tyr Asn Thr Asp Thr Ala Ile Asn Lys Val Thr Val Ile Gly Gly 
        435                 440                 445             
Asn Asn Ala Asp Ile Asn Ala Pro Tyr Gly Tyr Leu Lys Val Pro Gly 
    450                 455                 460                 
Asp Leu Asn Arg Gly Ala Gly Gly Asn Phe Ile Tyr Ala Cys Thr Phe 
465                 470                 475                 480 
Val Gly Lys 
            

<210>  202
<211>  483
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  202
Met Glu His Val Asp Leu Pro Thr Gly Leu Val Lys Phe Ser Ser Asn 
1               5                   10                  15      
His His Leu Gln Leu Leu Arg Asp Thr Ala Asp Leu Ser Glu Ser Val 
            20                  25                  30          
Leu Pro Gly Val Glu Ala Ile Gly Leu Gly Tyr Asn Pro Phe Leu Gly 
        35                  40                  45              
Tyr Ala Gly Val Gly Ser Gly Thr Val Gln Leu Phe Asp Trp Asn Asn 
    50                  55                  60                  
Ala Lys Lys Lys Lys Val Ser Phe Lys Pro Glu Phe Val Val Pro Glu 
65                  70                  75                  80  
Ile Val Asp Val Gln Gln Asn Asp Ser Ala Ser Tyr Thr Asn Ile Ser 
                85                  90                  95      
Gly Asn Thr Val Thr Glu Tyr Gln Arg Ser Leu Ala Val Ser Val Ala 
            100                 105                 110         
Ile Glu Gly Lys Tyr Asn Phe Phe Ser Gly Ser Leu Ser Thr Asp Tyr 
        115                 120                 125             
Asp Glu Asn Ser Leu Arg Asn Ala Glu Asn Glu Phe Thr Arg Ile Gln 
    130                 135                 140                 
Gln Ser Ile Asn Leu Trp Ser Leu Arg Leu Pro Ser Val Lys Ser Leu 
145                 150                 155                 160 
Arg Asp Leu Met Leu Pro His Met Arg Glu Gln Leu Asp Glu Leu Asp 
                165                 170                 175     
Val Lys Asn Pro Ser Ala Ile Ser Arg Phe Phe Asp Arg Val Gly Ser 
            180                 185                 190         
His Phe Leu Thr Gly Ile Val Met Gly Gly Arg Ala Ile Leu Ala Ala 
        195                 200                 205             
Ser Thr Asn Lys Leu Lys Val Lys Arg Asp Tyr Ser Val Ser Val Val 
    210                 215                 220                 
Ala Lys Ala Ser Tyr Glu Gly Leu Thr Gly Gln Leu Ser Ala Glu Ala 
225                 230                 235                 240 
Arg Thr Lys Tyr Gly Glu Ser Met Ser Ser Phe Thr Gln Tyr Ser Ser 
                245                 250                 255     
Thr His Gln Glu Val Arg Gly Gly Asp Gly Thr Lys Ala His Gly Val 
            260                 265                 270         
Phe Glu Gly Lys Ala Gly Phe Gln Ala Trp Val Asp Ser Val Ser Ala 
        275                 280                 285             
Ser Pro Asp Phe Val Asp Phe Val Pro Thr Ile Pro Met Gln Glu Ile 
    290                 295                 300                 
Trp Thr Leu Cys Lys Thr Asp Ser Gln Ala Glu Ala Met Arg Lys His 
305                 310                 315                 320 
Tyr Asp Asp Val Trp Ala Arg Glu Gln Ser Asp Lys Tyr Arg Ile Lys 
                325                 330                 335     
Ala Asn Tyr Ile Asp Gln Leu Val Val Ile Thr Gly Gly Ser Ser Thr 
            340                 345                 350         
Ile Glu Pro Pro Val Gly Tyr Ser Lys Ile Glu Tyr Asp Leu Asn Ala 
        355                 360                 365             
Gly Ala Gly Gly Asp Phe Ile Tyr Leu Cys Tyr His Glu Gln Thr Trp 
    370                 375                 380                 
Gln Ala Asp Arg Pro Lys Asp Ala Val Thr Asp Ile Arg Ile Ile Phe 
385                 390                 395                 400 
Asn Lys Glu Pro Thr Pro Pro Gly Tyr Thr Lys Leu Pro Gln Asp Leu 
                405                 410                 415     
Asn Lys Gly Ala Gly Gly Asp Asp Val Phe Leu Cys Tyr Lys Thr Glu 
            420                 425                 430         
Ala Tyr Asn Thr Asp Thr Ala Ile Asn Lys Val Thr Val Ile Gly Gly 
        435                 440                 445             
Asn Asn Ala Asp Ile Asn Ala Pro Tyr Gly Tyr Leu Lys Val Pro Gly 
    450                 455                 460                 
Asp Leu Asn Arg Gly Ala Gly Gly Asn Phe Ile Tyr Ala Cys Thr Phe 
465                 470                 475                 480 
Val Gly Lys 
            

<210>  203
<211>  1473
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  203
atggaaaaca tagacttgcc acaaggactt gtaaactttt ccacgcaaca cctgcaactt       60
attcgtttta aagcaggttt gaatgaaacc gtactacctg gcgtcgaagc ccttggactt      120
ggctataacc cattcatcag ttatgccagt gtcaacagcg gcgcggtgca attgttcgac      180
tgggccacgg ccaagaaacg cgaagtgcct ttcaaagccg gctacttcgt acccgagatc      240
gtcgacgtgc aacagaacga cagcgcaacc tacaccaacg tcagcggcaa cacgatcagc      300
gagtaccagc gcagtctggc taccagcgtc gccatcgaag gccgttacaa cttcttcagt      360
ggctcgctgt ccacggattt cgacagtaat tcactgcgca acgcggaaaa cgagttcact      420
cgcattcagc aatcgatcaa cctctggtcg ttgcgcttgc cttcggtgaa gtcattgcgc      480
gaactgatgc tgccacacat gcgccaacaa ctagatgaat tgaacgtcaa cgacccgaag      540
gccataagcc gctatttcga tagagttggc agccatttcc ttaccggcat cgtaatgggt      600
ggacgggcca tcctcgcctc ctcgaccaac aagctcaggg tcaagcgtga ctactcggtg      660
tcggtggtcg ccaaggcgag ctacgaaggg cttaccggcc agttgagcgc agaagccaaa      720
gccaagtatg gcgagtcgat cagcagcttc actcagtact ccaataccca ccaggaagtg      780
cgcggcggcg acggtgccaa ggcacatggg gtgttcagcg gcaaaaaaga agatttccag      840
gcctgggtag acagtgtgag cgcctcgccg gacttcgtcg atttcgtccc caccatcccc      900
atgcaggaaa tctggaccct gtgcagcagc gaggcgcagg ccgaggccat gcgcaagcat      960
tacgatgacg tctgggcgcc ggcgcaatcg gaaaagtacc gggtcaaggc taactacatc     1020
gaccaactgg tggtcatcac cggcggtagt tcaaccatcg aaccaccggt cggctacagc     1080
aagatcgagt acgacctcaa tgccggtgcc ggcggtgact tcatctactt gtgctatcac     1140
gaacaaacct ggcaggccga caggcctaaa gatgctgtga cggatatcag gatcattttc     1200
aacaaggagc ctaccccacc tggctatacc aagctgcccc aggacctgaa caagggcgcg     1260
ggcggtgatg atgtattcct ctgctacaag accgaggctt acaacaccga caccgcaatc     1320
aacaaggtca cggtcatcgg cggcaacaat gcggatatca acgctcccta tggttatctg     1380
aaggtccccg gtgacctcaa cagaggtgct ggcggcaact tcatctatgc ctgtaccttc     1440
gtaggcaagc tcgagcacca ccaccaccac cac                                  1473

<210>  204
<211>  1473
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  204
atggaaaacc tagacttgcc acaaggactt gtaaactttt ccacgcaaca cctgcaactt       60
attcgtttta aagcaggttt gaatgaaacc gtactacctg gcgtcgaagc ccttggactt      120
ggctataacc cattcatcag ttatgccagt gtcaacagcg gcgcggtgca attgttcgac      180
tgggccacgg ccaagaaacg cgaagtgcct ttcaaagccg gctacttcgt acccgagatc      240
gtcgacgtgc aacagaacga cagcgcaacc tacaccaacg tcagcggcaa cacgatcagc      300
gagtaccagc gcagtctggc taccagcgtc gccatcgaag gccgttacaa cttcttcagt      360
ggctcgctgt ccacggattt cgacagtaat tcactgcgca acgcggaaaa cgagttcact      420
cgcattcagc aatcgatcaa cctctggtcg ttgcgcttgc cttcggtgaa gtcattgcgc      480
gaactgatgc tgccacacat gcgccaacaa ctagatgaat tgaacgtcaa cgacccgaag      540
gccataagcc gctatttcga tagagttggc agccatttcc ttaccggcat cgtaatgggt      600
ggacgggcca tcctcgcctc ctcgaccaac aagctcaggg tcaagcgtga ctactcggtg      660
tcggtggtcg ccaaggcgag ctacgaaggg cttaccggcc agttgagcgc agaagccaaa      720
gccaagtatg gcgagtcgat cagcagcttc actcagtact ccaataccca ccaggaagtg      780
cgcggcggcg acggtgccaa ggcacatggg gtgttcagcg gcaaaaaaga agatttccag      840
gcctgggtag acagtgtgag cgcctcgccg gacttcgtcg atttcgtccc caccatcccc      900
atgcaggaaa tctggaccct gtgcagcagc gaggcgcagg ccgaggccat gcgcaagcat      960
tacgatgacg tctgggcgcc ggcgcaatcg gaaaagtacc gggtcaaggc taactacatc     1020
gaccaactgg tggtcatcac cggcggtagt tcaaccatcg aaccaccggt cggctacagc     1080
aagatcgagt acgacctcaa tgccggtgcc ggcggtgact tcctctactt gtgctatcac     1140
gaacaaacct ggcaggccga caggcctaaa gatgctgtga cggatatcag gatcattttc     1200
aacaaggagc ctaccccacc tggctatacc aagctgcccc aggacctgaa caagggcgcg     1260
ggcggtgatg atgtattcct ctgctacaag accgaggctt acaacaccga caccgcaatc     1320
aacaaggtca cggtcatcgg cggcaacaat gcggatatca acgctcccta tggttatctg     1380
aaggtccccg gtgacctcaa cagaggtgct ggcggcaact tcatctatgc ctgtaccttc     1440
gtaggcaagc tcgagcacca ccaccaccac cac                                  1473

<210>  205
<211>  1473
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  205
atggaaaaca tagacttgcc acaaggactt gtaaactttt ccacgcaaca cctgcaactt       60
attcgtttta aagcaggttt gaatgaaacc gtactacctg gcgtcgaagc cattggactt      120
ggctataacc cattcatcag ttatgccagt gtcaacagcg gcgcggtgca attgttcgac      180
tgggccacgg ccaagaaacg cgaagtgcct ttcaaagccg gctacttcgt acccgagatc      240
gtcgacgtgc aacagaacga cagcgcaacc tacaccaacg tcagcggcaa cacgatcagc      300
gagtaccagc gcagtctggc taccagcgtc gccatcgaag gccgttacaa cttcttcagt      360
ggctcgctgt ccacggattt cgacagtaat tcactgcgca acgcggaaaa cgagttcact      420
cgcattcagc aatcgatcaa cctctggtcg ttgcgcttgc cttcggtgaa gtcattgcgc      480
gaactgatgc tgccacacat gcgccaacaa ctagatgaat tgaacgtcaa cgacccgaag      540
gccataagcc gctatttcga tagagttggc agccatttcc ttaccggcat cgtaatgggt      600
ggacgggcca tcctcgcctc ctcgaccaac aagctcaggg tcaagcgtga ctactcggtg      660
tcggtggtcg ccaaggcgag ctacgaaggg cttaccggcc agttgagcgc agaagccaaa      720
gccaagtatg gcgagtcgat cagcagcttc actcagtact ccaataccca ccaggaagtg      780
cgcggcggcg acggtgccaa ggcacatggg gtgttcagcg gcaaaaaaga agatttccag      840
gcctgggtag acagtgtgag cgcctcgccg gacttcgtcg atttcgtccc caccatcccc      900
atgcaggaaa tctggaccct gtgcagcagc gaggcgcagg ccgaggccat gcgcaagcat      960
tacgatgacg tctgggcgcc ggcgcaatcg gaaaagtacc gggtcaaggc taactacctc     1020
gaccaactgg tggtcatcac cggcggtagt tcaaccatcg aaccaccggt cggctacagc     1080
aagatcgagt acgacctcaa tgccggtgcc ggcggtgact tcatctactt gtgctatcac     1140
gaacaaacct ggcaggccga caggcctaaa gatgctgtga cggatatcag gatcattttc     1200
aacaaggagc ctaccccacc tggctatacc aagctgcccc aggacctgaa caagggcgcg     1260
ggcggtgatg atgtattcct ctgctacaag accgaggctt acaacaccga caccgcaatc     1320
aacaaggtca cggtcatcgg cggcaacaat gcggatatca acgctcccta tggttatctg     1380
aaggtccccg gtgacctcaa cagaggtgct ggcggcaact tcatctatgc ctgtaccttc     1440
gtaggcaagc tcgagcacca ccaccaccac cac                                  1473

<210>  206
<211>  1473
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  206
atggaaaaca tagacttgcc acaaggactt gtaaactttt ccacgcaaca cctgcaactt       60
attcgtttta aagcaggttt gaatgaaacc gtactacctg gcgtcgaagc cattggactt      120
ggctataacc cattcatcag ttatgccagt gtcaacagcg gcgcggtgca attgttcgac      180
tgggccacgg ccaagaaacg cgaagtgcct ttcaaagccg gctacttcgt acccgagatc      240
gtcgacgtgc aacagaacga cagcgcaacc tacaccaacg tcagcggcaa cacgatcagc      300
gagtaccagc gcagtctggc taccagcgtc gccatcgaag gccgttacaa cttcttcagt      360
ggctcgctgt ccacggattt cgacagtaat tcactgcgca acgcggaaaa cgagttcact      420
cgcattcagc aatcgatcaa cctctggtcg ttgcgcttgc cttcggtgaa gtcattgcgc      480
gaactgatgc tgccacacat gcgccaacaa ctagatgaat tgaacgtcaa cgacccgaag      540
gccataagcc gctatttcga tagagttggc agccatttcc ttaccggcat cgtaatgggt      600
ggacgggcca tcctcgcctc ctcgaccaac aagctcaggg tcaagcgtga ctactcggtg      660
tcggtggtcg ccaaggcgag ctacgaaggg cttaccggcc agttgagcgc agaagccaaa      720
gccaagtatg gcgagtcgat cagcagcttc actcagtact ccaataccca ccaggaagtg      780
cgcggcggcg acggtgccaa ggcacatggg gtgttcagcg gcaaaaaaga agatttccag      840
gcctgggtag acagtgtgag cgcctcgccg gacttcgtcg atttcgtccc caccatcccc      900
atgcaggaaa tctggaccct gtgcagcagc gaggcgcagg ccgaggccat gcgcaagcat      960
tacgatgacg tctgggcgcc ggcgcaatcg gaaaagtacc gggtcaaggc taactacatc     1020
gaccaactgg tggtcatcac cggcggtagt tcaaccatcg aaccaccggt cggctacagc     1080
aagatcgagt acgacctcaa tgccggtgcc ggcggtgact tcctctactt gtgctatcac     1140
gaacaaacct ggcaggccga caggcctaaa gatgctgtga cggatatcag gatcattttc     1200
aacaaggagc ctaccccacc tggctatacc aagctgcccc aggacctgaa caagggcgcg     1260
ggcggtgatg atgtattcct ctgctacaag accgaggctt acaacaccga caccgcaatc     1320
aacaaggtca cggtcatcgg cggcaacaat gcggatatca acgctcccta tggttatctg     1380
aaggtccccg gtgacctcaa cagaggtgct ggcggcaact tcatctatgc ctgtaccttc     1440
gtaggcaagc tcgagcacca ccaccaccac cac                                  1473

<210>  207
<211>  1467
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  207
atggaaaaca tagacttgcc acaaggactt gtaaactttt ccacgcaaca cctgcaactt       60
attcgtttta aagcaggttt gaatgaaacc gtactacctg gcgtcgaagc cattggactt      120
ggctataacc cattcatcag ttatgccagt gtcaacagcg gcgcggtgca attgttcgac      180
tgggccacgg ccaagaaacg cgaagtgcct ttcaaagccg gctacttcgt acccgagctc      240
gtcgacgtgc aacagaacga cagcgcaacc tacaccaacg tcagcggcaa cacgatcagc      300
gagtaccagc gcagtctggc taccagcgtc gccatcgaag gccgttacaa cttcttcagt      360
ggctcgctgt ccacggattt cgacagtaat tcactgcgca acgcggaaaa cgagttcact      420
cgcattcagc aatcgatcaa cctctggtcg ttgcgcttgc cttcggtgaa gtcattgcgc      480
gaactgatgc tgccacacat gcgccaacaa ctagatgaat tgaacgtcaa cgacccgaag      540
gccataagcc gctatttcga tagagttggc agccatttcc ttaccggcat cgtaatgggt      600
ggacgggcca tcctcgcctc ctcgaccaac aagctcaggg tcaagcgtga ctactcggtg      660
tcggtggtcg ccaaggcgag ctacgaaggg cttaccggcc agttgagcgc agaagccaaa      720
gccaagtatg gcgagtcgat cagcagcttc actcagtact ccaataccca ccaggaagtg      780
cgcggcggcg acggtgccaa ggcacatggg gtgttcagcg gcaaaaaaga agatttccag      840
gcctgggtag acagtgtgag cgcctcgccg gacttcgtcg atttcgtccc caccatcccc      900
atgcaggaaa tctggaccct gtgcagcagc gaggcgcagg ccgaggccat gcgcaagcat      960
tacgatgacg tctgggcgcc ggcgcaatcg gaaaagtacc gggtcaaggc taactacatc     1020
gaccaactgg tggtcatcac cggcggtagt tcaaccatcg aaccaccggt cggctacagc     1080
aagatcgagt acgacctcaa tgccggtgcc ggcggtgact tcatctactt gtgctatcac     1140
gaacaaacct ggcaggccga caggcctaaa gatgctgtga cggatatcag gatcattttc     1200
aacaaggagc ctaccccacc tggctatacc aagctgcccc aggacctgaa caagggcgcg     1260
ggcggtgatg atgtattcct ctgctacaag accgaggctt acaacaccga caccgcaatc     1320
aacaaggtca cggtcatcgg cggcaacaat gcggatatca acgctcccta tggttatctg     1380
aaggtccccg gtgacctcaa cagaggtgct ggcggcaact tcatctatgc ctgtaccttc     1440
gtaggcaagc accaccacca ccaccac                                         1467

<210>  208
<211>  1449
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  208
atggaaaaca tagacttgcc acaaggactt gtaaactttt ccacgcaaca cctgcaactt       60
attcgtttta aagcaggttt gaatgaaacc gtactacctg gcgtcgaagc cattggactt      120
ggctataacc cattcatcag ttatgccagt gtcaacagcg gcgcggtgca attgttcgac      180
tgggccacgg ccaagaaacg cgaagtgcct ttcaaagccg gctacttcgt acccgagctc      240
gtcgacgtgc aacagaacga cagcgcaacc tacaccaacg tcagcggcaa cacgatcagc      300
gagtaccagc gcagtctggc taccagcgtc gccatcgaag gccgttacaa cttcttcagt      360
ggctcgctgt ccacggattt cgacagtaat tcactgcgca acgcggaaaa cgagttcact      420
cgcattcagc aatcgatcaa cctctggtcg ttgcgcttgc cttcggtgaa gtcattgcgc      480
gaactgatgc tgccacacat gcgccaacaa ctagatgaat tgaacgtcaa cgacccgaag      540
gccataagcc gctatttcga tagagttggc agccatttcc ttaccggcat cgtaatgggt      600
ggacgggcca tcctcgcctc ctcgaccaac aagctcaggg tcaagcgtga ctactcggtg      660
tcggtggtcg ccaaggcgag ctacgaaggg cttaccggcc agttgagcgc agaagccaaa      720
gccaagtatg gcgagtcgat cagcagcttc actcagtact ccaataccca ccaggaagtg      780
cgcggcggcg acggtgccaa ggcacatggg gtgttcagcg gcaaaaaaga agatttccag      840
gcctgggtag acagtgtgag cgcctcgccg gacttcgtcg atttcgtccc caccatcccc      900
atgcaggaaa tctggaccct gtgcagcagc gaggcgcagg ccgaggccat gcgcaagcat      960
ttcgatgacg tctgggcgcc ggcgcaatcg gaaaagttcc gggtcaaggc taactacatc     1020
gaccaactgg tggtcatcac cggcggtagt tcaaccatcg aaccaccggt cggctacagc     1080
aagatcgagt acgacctcaa tgccggtgcc ggcggtgact tcatctactt gtgctatcac     1140
gaacaaacct ggcaggccga caggcctaaa gatgctgtga cggatatcag gatcattttc     1200
aacaaggagc ctaccccacc tggctatacc aagctgcccc aggacctgaa caagggcgcg     1260
ggcggtgatg atgtattcct ctgctacaag accgaggctt tcaacaccga caccgcaatc     1320
aacaaggtca cggtcctcgg cggcaacaat gcggatctca acgctcccta tggttatctg     1380
aaggtccccg gtgacctcaa cagaggtgct ggcggcaact tcatctatgc ctgtaccttc     1440
gtaggcaag                                                             1449

<210>  209
<211>  1449
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  209
atggaaaaca tagacttgcc acaaggactt gtaaactttt ccacgcaaca cctgcaactt       60
attcgtttta aagcaggttt gaatgaaacc gtactacctg gcgtcgaagc cattggactt      120
ggctataacc cattcatcag ttatgccagt gtcaacagcg gcgcggtgca attgttcgac      180
tgggccacgg ccaagaaacg cgaagtgcct ttcaaagccg gctacttcgt acccgagctc      240
gtcgacgtgc aacagaacga cagcgcaacc tacaccaacg tcagcggcaa cacgctcagc      300
gagtaccagc gcagtctggc taccagcgtc gccatcgaag gccgttacaa cttcttcagt      360
ggctcgctgt ccacggattt cgacagtaat tcactgcgca acgcggaaaa cgagttcact      420
cgcattcagc aatcgatcaa cctctggtcg ttgcgcttgc cttcggtgaa gtcattgcgc      480
gaactgatgc tgccacacat gcgccaacaa ctagatgaat tgaacgtcaa cgacccgaag      540
gccataagcc gctatttcga tagagttggc agccatttcc ttaccggcat cgtaatgggt      600
ggacgggcca tcctcgcctc ctcgaccaac aagctcaggg tcaagcgtga ctactcggtg      660
tcggtggtcg ccaaggcgag ctacgaaggg cttaccggcc agttgagcgc agaagccaaa      720
gccaagtatg gcgagtcgat cagcagcttc actcagtact ccaataccca ccaggaagtg      780
cgcggcggcg acggtgccaa ggcacatggg gtgttcagcg gcaaaaaaga agatttccag      840
gcctgggtag acagtgtgag cgcctcgccg gacttcgtcg atttcgtccc caccatcccc      900
atgcaggaaa tctggaccct gtgcagcagc gaggcgcagg ccgaggccat gcgcaagcat      960
ttcgatgacg tctgggcgcc ggcgcaatcg gaaaagttcc gggtcaaggc taactacatc     1020
gaccaactgg tggtcatcac cggcggtagt tcaaccctcg aaccaccggt cggctacagc     1080
aagatcgagt acgacctcaa tgccggtgcc ggcggtgact tcatctactt gtgctatcac     1140
gaacaaacct ggcaggccga caggcctaaa gatgctgtga cggatatcag gatcattttc     1200
aacaaggagc ctaccccacc tggctatacc aagctgcccc aggacctgaa caagggcgcg     1260
ggcggtgatg atgtattcct ctgctacaag accgaggctt tcaacaccga caccgcaatc     1320
aacaaggtca cggtcatcgg cggcaacaat gcggatctca acgctcccta tggttatctg     1380
aaggtccccg gtgacctcaa cagaggtgct ggcggcaact tcatctatgc ctgtaccttc     1440
gtaggcaag                                                             1449

<210>  210
<211>  1449
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  210
atggaaaaca tagacttgcc acaaggactt gtaaactttt ccacgcaaca cctgcaactt       60
attcgtttta aagcaggttt gaatgaaacc gtactacctg gcgtcgaagc cattggactt      120
ggctataacc cattcatcag ttatgccagt gtcaacagcg gcgcggtgca attgttcgac      180
tgggccacgg ccaagaaacg cgaagtgcct ttcaaagccg gctacttcgt acccgagctc      240
gtcgacgtgc aacagaacga cagcgcaacc ttcaccaacg tcagcggcaa cacgctcagc      300
gagtaccagc gcagtctggc taccagcgtc gccatcgaag gccgttacaa cttcttcagt      360
ggctcgctgt ccacggattt cgacagtaat tcactgcgca acgcggaaaa cgagttcact      420
cgcattcagc aatcgatcaa cctctggtcg ttgcgcttgc cttcggtgaa gtcattgcgc      480
gaactgatgc tgccacacat gcgccaacaa ctagatgaat tgaacgtcaa cgacccgaag      540
gccataagcc gctatttcga tagagttggc agccatttcc ttaccggcat cgtaatgggt      600
ggacgggcca tcctcgcctc ctcgaccaac aagctcaggg tcaagcgtga ctactcggtg      660
tcggtggtcg ccaaggcgag ctacgaaggg cttaccggcc agttgagcgc agaagccaaa      720
gccaagtatg gcgagtcgat cagcagcttc actcagtact ccaataccca ccaggaagtg      780
cgcggcggcg acggtgccaa ggcacatggg gtgttcagcg gcaaaaaaga agatttccag      840
gcctgggtag acagtgtgag cgcctcgccg gacttcgtcg atttcgtccc caccatcccc      900
atgcaggaaa tctggaccct gtgcagcagc gaggcgcagg ccgaggccat gcgcaagcat      960
tacgatgacg tctgggcgcc ggcgcaatcg gaaaagtacc gggtcaaggc taactacatc     1020
gaccaactgg tggtcatcac cggcggtagt tcaaccctcg aaccaccggt cggctacagc     1080
aagatcgagt acgacctcaa tgccggtgcc ggcggtgact tcatctactt gtgctatcac     1140
gaacaaacct ggcaggccga caggcctaaa gatgctgtga cggatatcag gatcattttc     1200
aacaaggagc ctaccccacc tggctatacc aagctgcccc aggacctgaa caagggcgcg     1260
ggcggtgatg atgtattcct ctgctacaag accgaggctt acaacaccga caccgcactc     1320
aacaaggtca cggtcatcgg cggcaacaat gcggatatca acgctccctt tggttatctg     1380
aaggtccccg gtgacctcaa cagaggtgct ggcggcaact tcatctatgc ctgtaccttc     1440
gtaggcaag                                                             1449

<210>  211
<211>  1449
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  211
atggaaaaca tagacttgcc acaaggactt gtaaactttt ccacgcaaca cctgcaactt       60
attcgtttta aagcaggttt gaatgaaacc gtactacctg gcgtcgaagc cattggactt      120
ggctataacc cattcatcag ttatgccagt gtcaacagcg gcgcggtgca attgttcgac      180
tgggccacgg ccaagaaacg cgaagtgcct ttcaaagccg gctacttcgt acccgagctc      240
gtcgacgtgc aacagaacga cagcgcaacc tacaccaacg tcagcggcaa cacgatcagc      300
gagtaccagc gcagtctggc taccagcgtc gccatcgaag gccgttacaa cttcttcagt      360
ggctcgctgt ccacggattt cgacagtaat tcactgcgca acgcggaaaa cgagttcact      420
cgcattcagc aatcgatcaa cctctggtcg ttgcgcttgc cttcggtgaa gtcattgcgc      480
gaactgatgc tgccacacat gcgccaacaa ctagatgaat tgaacgtcaa cgacccgaag      540
gccataagcc gctatttcga tagagttggc agccatttcc ttaccggcat cgtaatgggt      600
ggacgggcca tcctcgcctc ctcgaccaac aagctcaggg tcaagcgtga ctactcggtg      660
tcggtggtcg ccaaggcgag ctacgaaggg cttaccggcc agttgagcgc agaagccaaa      720
gccaagtatg gcgagtcgat cagcagcttc actcagtact ccaataccca ccaggaagtg      780
cgcggcggcg acggtgccaa ggcacatggg gtgttcagcg gcaaaaaaga agatttccag      840
gcctgggtag acagtgtgag cgcctcgccg gacttcgtcg atttcgtccc caccatcccc      900
atgcaggaaa tctggaccct gtgcagcagc gaggcgcagg ccgaggccat gcgcaagcat      960
tacgatgacg tctgggcgcc ggcgcaatcg gaaaagttcc gggtcaaggc taactacctc     1020
gaccaactgg tggtcatcac cggcggtagt tcaaccatcg aaccaccggt cggctacagc     1080
aagatcgagt acgacctcaa tgccggtgcc ggcggtgact tcatctactt gtgctatcac     1140
gaacaaacct ggcaggccga caggcctaaa gatgctgtga cggatatcag gatcattttc     1200
aacaaggagc ctaccccacc tggctatacc aagctgcccc aggacctgaa caagggcgcg     1260
ggcggtgatg atgtattcct ctgctacaag accgaggctt acaacaccga caccgcaatc     1320
aacaaggtca cggtcctcgg cggcaacaat gcggatatca acgctccctt tggttatctg     1380
aaggtccccg gtgacctcaa cagaggtgct ggcggcaact tcatctatgc ctgtaccttc     1440
gtaggcaag                                                             1449

<210>  212
<211>  1449
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  212
atggaaaaca tagacttgcc acaaggactt gtaaactttt ccacgcaaca cctgcaactt       60
attcgtttta aagcaggttt gaatgaaacc gtactacctg gcgtcgaagc cattggactt      120
ggctataacc cattcatcag ttatgccagt gtcaacagcg gcgcggtgca attgttcgac      180
tgggccacgg ccaagaaacg cgaagtgcct ttcaaagccg gctacttcgt acccgagctc      240
gtcgacgtgc aacagaacga cagcgcaacc tacaccaacg tcagcggcaa cacgctcagc      300
gagtaccagc gcagtctggc taccagcgtc gccatcgaag gccgttacaa cttcttcagt      360
ggctcgctgt ccacggattt cgacagtaat tcactgcgca acgcggaaaa cgagttcact      420
cgcattcagc aatcgatcaa cctctggtcg ttgcgcttgc cttcggtgaa gtcattgcgc      480
gaactgatgc tgccacacat gcgccaacaa ctagatgaat tgaacgtcaa cgacccgaag      540
gccataagcc gctatttcga tagagttggc agccatttcc ttaccggcat cgtaatgggt      600
ggacgggcca tcctcgcctc ctcgaccaac aagctcaggg tcaagcgtga ctactcggtg      660
tcggtggtcg ccaaggcgag ctacgaaggg cttaccggcc agttgagcgc agaagccaaa      720
gccaagtatg gcgagtcgat cagcagcttc actcagtact ccaataccca ccaggaagtg      780
cgcggcggcg acggtgccaa ggcacatggg gtgttcagcg gcaaaaaaga agatttccag      840
gcctgggtag acagtgtgag cgcctcgccg gacttcgtcg atttcgtccc caccatcccc      900
atgcaggaaa tctggaccct gtgcagcagc gaggcgcagg ccgaggccat gcgcaagcat      960
tacgatgacg tctgggcgcc ggcgcaatcg gaaaagttcc gggtcaaggc taactacatc     1020
gaccaactgg tggtcatcac cggcggtagt tcaaccatcg aaccaccggt cggctacagc     1080
aagatcgagt acgacctcaa tgccggtgcc ggcggtgact tcatctactt gtgctatcac     1140
gaacaaacct ggcaggccga caggcctaaa gatgctgtga cggatatcag gatcattttc     1200
aacaaggagc ctaccccacc tggctatacc aagctgcccc aggacctgaa caagggcgcg     1260
ggcggtgatg atgtattcct ctgctacaag accgaggctt tcaacaccga caccgcaatc     1320
aacaaggtca cggtcatcgg cggcaacaat gcggatatca acgctcccta tggttatctg     1380
aaggtccccg gtgacctcaa cagaggtgct ggcggcaact tcatctatgc ctgtaccttc     1440
gtaggcaag                                                             1449

<210>  213
<211>  1449
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  213
atggaaaaca tagacttgcc acaaggactt gtaaactttt ccacgcaaca cctgcaactt       60
attcgtttta aagcaggttt gaatgaaacc gtactacctg gcgtcgaagc cattggactt      120
ggctataacc cattcatcag ttatgccagt gtcaacagcg gcgcggtgca attgttcgac      180
tgggccacgg ccaagaaacg cgaagtgcct ttcaaagccg gctacttcgt acccgagctc      240
gtcgacgtgc aacagaacga cagcgcaacc ttcaccaacg tcagcggcaa cacgatcagc      300
gagtaccagc gcagtctggc taccagcgtc gccatcgaag gccgttacaa cttcttcagt      360
ggctcgctgt ccacggattt cgacagtaat tcactgcgca acgcggaaaa cgagttcact      420
cgcattcagc aatcgatcaa cctctggtcg ttgcgcttgc cttcggtgaa gtcattgcgc      480
gaactgatgc tgccacacat gcgccaacaa ctagatgaat tgaacgtcaa cgacccgaag      540
gccataagcc gctatttcga tagagttggc agccatttcc ttaccggcat cgtaatgggt      600
ggacgggcca tcctcgcctc ctcgaccaac aagctcaggg tcaagcgtga ctactcggtg      660
tcggtggtcg ccaaggcgag ctacgaaggg cttaccggcc agttgagcgc agaagccaaa      720
gccaagtatg gcgagtcgat cagcagcttc actcagtact ccaataccca ccaggaagtg      780
cgcggcggcg acggtgccaa ggcacatggg gtgttcagcg gcaaaaaaga agatttccag      840
gcctgggtag acagtgtgag cgcctcgccg gacttcgtcg atttcgtccc caccatcccc      900
atgcaggaaa tctggaccct gtgcagcagc gaggcgcagg ccgaggccat gcgcaagcat      960
tacgatgacg tctgggcgcc ggcgcaatcg gaaaagtacc gggtcaaggc taacttcatc     1020
gaccaactgg tggtcatcac cggcggtagt tcaaccctcg aaccaccggt cggctacagc     1080
aagatcgagt acgacctcaa tgccggtgcc ggcggtgact tcatctactt gtgctatcac     1140
gaacaaacct ggcaggccga caggcctaaa gatgctgtga cggatatcag gatcattttc     1200
aacaaggagc ctaccccacc tggctatacc aagctgcccc aggacctgaa caagggcgcg     1260
ggcggtgatg atgtattcct ctgctacaag accgaggctt acaacaccga caccgcactc     1320
aacaaggtca cggtcatcgg cggcaacaat gcggatatca acgctcccta tggttatctg     1380
aaggtccccg gtgacctcaa cagaggtgct ggcggcaact tcatctatgc ctgtaccttc     1440
gtaggcaag                                                             1449

<210>  214
<211>  1449
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  214
atggaaaaca tagacttgcc acaaggactt gtaaactttt ccacgcaaca cctgcaactt       60
attcgtttta aagcaggttt gaatgaaacc gtactacctg gcgtcgaagc cattggactt      120
ggctataacc cattcatcag ttatgccagt gtcaacagcg gcgcggtgca attgttcgac      180
tgggccacgg ccaagaaacg cgaagtgcct ttcaaagccg gctacttcgt acccgagctc      240
gtcgacgtgc aacagaacga cagcgcaacc ttcaccaacg tcagcggcaa cacgatcagc      300
gagtaccagc gcagtctggc taccagcgtc gccatcgaag gccgttacaa cttcttcagt      360
ggctcgctgt ccacggattt cgacagtaat tcactgcgca acgcggaaaa cgagttcact      420
cgcattcagc aatcgatcaa cctctggtcg ttgcgcttgc cttcggtgaa gtcattgcgc      480
gaactgatgc tgccacacat gcgccaacaa ctagatgaat tgaacgtcaa cgacccgaag      540
gccataagcc gctatttcga tagagttggc agccatttcc ttaccggcat cgtaatgggt      600
ggacgggcca tcctcgcctc ctcgaccaac aagctcaggg tcaagcgtga ctactcggtg      660
tcggtggtcg ccaaggcgag ctacgaaggg cttaccggcc agttgagcgc agaagccaaa      720
gccaagtatg gcgagtcgat cagcagcttc actcagtact ccaataccca ccaggaagtg      780
cgcggcggcg acggtgccaa ggcacatggg gtgttcagcg gcaaaaaaga agatttccag      840
gcctgggtag acagtgtgag cgcctcgccg gacttcgtcg atttcgtccc caccatcccc      900
atgcaggaaa tctggaccct gtgcagcagc gaggcgcagg ccgaggccat gcgcaagcat      960
ttcgatgacg tctgggcgcc ggcgcaatcg gaaaagttcc gggtcaaggc taactacctc     1020
gaccaactgg tggtcctcac cggcggtagt tcaaccatcg aaccaccggt cggctacagc     1080
aagctcgagt acgacctcaa tgccggtgcc ggcggtgact tcatctactt gtgctatcac     1140
gaacaaacct ggcaggccga caggcctaaa gatgctgtga cggatatcag gatcattttc     1200
aacaaggagc ctaccccacc tggctatacc aagctgcccc aggacctgaa caagggcgcg     1260
ggcggtgatg atgtattcct ctgctacaag accgaggctt tcaacaccga caccgcactc     1320
aacaaggtca cggtcatcgg cggcaacaat gcggatatca acgctcccta tggttatctg     1380
aaggtccccg gtgacctcaa cagaggtgct ggcggcaact tcatctatgc ctgtaccttc     1440
gtaggcaag                                                             1449

<210>  215
<211>  1449
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  215
atggaaaaca tagacttgcc acaaggactt gtaaactttt ccacgcaaca cctgcaactt       60
attcgtttta aagcaggttt gaatgaaacc gtactacctg gcgtcgaagc cattggactt      120
ggctataacc cattcatcag ttatgccagt gtcaacagcg gcgcggtgca attgttcgac      180
tgggccacgg ccaagaaacg cgaagtgcct ttcaaagccg gctacttcgt acccgagctc      240
gtcgacgtgc aacagaacga cagcgcaacc tacaccaacg tcagcggcaa cacgatcagc      300
gagtaccagc gcagtctggc taccagcgtc gccatcgaag gccgttacaa cttcttcagt      360
ggctcgctgt ccacggattt cgacagtaat tcactgcgca acgcggaaaa cgagttcact      420
cgcattcagc aatcgatcaa cctctggtcg ttgcgcttgc cttcggtgaa gtcattgcgc      480
gaactgatgc tgccacacat gcgccaacaa ctagatgaat tgaacgtcaa cgacccgaag      540
gccataagcc gctatttcga tagagttggc agccatttcc ttaccggcat cgtaatgggt      600
ggacgggcca tcctcgcctc ctcgaccaac aagctcaggg tcaagcgtga ctactcggtg      660
tcggtggtcg ccaaggcgag ctacgaaggg cttaccggcc agttgagcgc agaagccaaa      720
gccaagtatg gcgagtcgat cagcagcttc actcagtact ccaataccca ccaggaagtg      780
cgcggcggcg acggtgccaa ggcacatggg gtgttcagcg gcaaaaaaga agatttccag      840
gcctgggtag acagtgtgag cgcctcgccg gacttcgtcg atttcgtccc caccatcccc      900
atgcaggaaa tctggaccct gtgcagcagc gaggcgcagg ccgaggccat gcgcaagcat      960
tacgatgacg tctgggcgcc ggcgcaatcg gaaaagttcc gggtcaaggc taactacatc     1020
gaccaactgg tggtcatcac cggcggtagt tcaaccatcg aaccaccggt cggctacagc     1080
aagatcgagt acgacctcaa tgccggtgcc ggcggtgact tcatctactt gtgctatcac     1140
gaacaaacct ggcaggccga caggcctaaa gatgctgtga cggatatcag gatcattttc     1200
aacaaggagc ctaccccacc tggctatacc aagctgcccc aggacctgaa caagggcgcg     1260
ggcggtgatg atgtattcct ctgctacaag accgaggctt tcaacaccga caccgcaatc     1320
aacaaggtca cggtcatcgg cggcaacaat gcggatatca acgctcccta tggttatctg     1380
aaggtccccg gtgacctcaa cagaggtgct ggcggcaact tcatctatgc ctgtaccttc     1440
gtaggcaag                                                             1449

<210>  216
<211>  1449
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  216
atggaaaaca tagacttgcc acaaggactt gtaaactttt ccacgcaaca cctgcaactt       60
attcgtttta aagcaggttt gaatgaaacc gtactacctg gcgtcgaagc cattggactt      120
ggctataacc cattcatcag ttatgccagt gtcaacagcg gcgcggtgca attgttcgac      180
tgggccacgg ccaagaaacg cgaagtgcct ttcaaagccg gctacttcgt acccgagctc      240
gtcgacgtgc aacagaacga cagcgcaacc tacaccaacg tcagcggcaa cacgctcagc      300
gagtaccagc gcagtctggc taccagcgtc gccatcgaag gccgttacaa cttcttcagt      360
ggctcgctgt ccacggattt cgacagtaat tcactgcgca acgcggaaaa cgagttcact      420
cgcattcagc aatcgatcaa cctctggtcg ttgcgcttgc cttcggtgaa gtcattgcgc      480
gaactgatgc tgccacacat gcgccaacaa ctagatgaat tgaacgtcaa cgacccgaag      540
gccataagcc gctatttcga tagagttggc agccatttcc ttaccggcat cgtaatgggt      600
ggacgggcca tcctcgcctc ctcgaccaac aagctcaggg tcaagcgtga ctactcggtg      660
tcggtggtcg ccaaggcgag ctacgaaggg cttaccggcc agttgagcgc agaagccaaa      720
gccaagtatg gcgagtcgat cagcagcttc actcagtact ccaataccca ccaggaagtg      780
cgcggcggcg acggtgccaa ggcacatggg gtgttcagcg gcaaaaaaga agatttccag      840
gcctgggtag acagtgtgag cgcctcgccg gacttcgtcg atttcgtccc caccatcccc      900
atgcaggaaa tctggaccct gtgcagcagc gaggcgcagg ccgaggccat gcgcaagcat      960
tacgatgacg tctgggcgcc ggcgcaatcg gaaaagtacc gggtcaaggc taacttcatc     1020
gaccaactgg tggtcatcac cggcggtagt tcaaccatcg aaccaccggt cggctacagc     1080
aagatcgagt acgacctcaa tgccggtgcc ggcggtgact tcatctactt gtgctatcac     1140
gaacaaacct ggcaggccga caggcctaaa gatgctgtga cggatatcag gatcattttc     1200
aacaaggagc ctaccccacc tggctatacc aagctgcccc aggacctgaa caagggcgcg     1260
ggcggtgatg atgtattcct ctgctacaag accgaggctt acaacaccga caccgcaatc     1320
aacaaggtca cggtcatcgg cggcaacaat gcggatatca acgctccctt tggttatctg     1380
aaggtccccg gtgacctcaa cagaggtgct ggcggcaact tcatctatgc ctgtaccttc     1440
gtaggcaag                                                             1449

<210>  217
<211>  1449
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  217
atggaaaaca tagacttgcc acaaggactt gtaaactttt ccacgcaaca cctgcaactt       60
attcgtttta aagcaggttt gaatgaaacc gtactacctg gcgtcgaagc cattggactt      120
ggctataacc cattcatcag ttatgccagt gtcaacagcg gcgcggtgca attgttcgac      180
tgggccacgg ccaagaaacg cgaagtgcct ttcaaagccg gctacttcgt acccgagctc      240
gtcgacgtgc aacagaacga cagcgcaacc ttcaccaacg tcagcggcaa cacgatcagc      300
gagtaccagc gcagtctggc taccagcgtc gccatcgaag gccgttacaa cttcttcagt      360
ggctcgctgt ccacggattt cgacagtaat tcactgcgca acgcggaaaa cgagttcact      420
cgcattcagc aatcgatcaa cctctggtcg ttgcgcttgc cttcggtgaa gtcattgcgc      480
gaactgatgc tgccacacat gcgccaacaa ctagatgaat tgaacgtcaa cgacccgaag      540
gccataagcc gctatttcga tagagttggc agccatttcc ttaccggcat cgtaatgggt      600
ggacgggcca tcctcgcctc ctcgaccaac aagctcaggg tcaagcgtga ctactcggtg      660
tcggtggtcg ccaaggcgag ctacgaaggg cttaccggcc agttgagcgc agaagccaaa      720
gccaagtatg gcgagtcgat cagcagcttc actcagtact ccaataccca ccaggaagtg      780
cgcggcggcg acggtgccaa ggcacatggg gtgttcagcg gcaaaaaaga agatttccag      840
gcctgggtag acagtgtgag cgcctcgccg gacttcgtcg atttcgtccc caccatcccc      900
atgcaggaaa tctggaccct gtgcagcagc gaggcgcagg ccgaggccat gcgcaagcat      960
tacgatgacg tctgggcgcc ggcgcaatcg gaaaagttcc gggtcaaggc taactacatc     1020
gaccaactgg tggtcatcac cggcggtagt tcaaccatcg aaccaccggt cggctacagc     1080
aagctcgagt acgacctcaa tgccggtgcc ggcggtgact tcatctactt gtgctatcac     1140
gaacaaacct ggcaggccga caggcctaaa gatgctgtga cggatatcag gatcattttc     1200
aacaaggagc ctaccccacc tggctatacc aagctgcccc aggacctgaa caagggcgcg     1260
ggcggtgatg atgtattcct ctgctacaag accgaggctt acaacaccga caccgcaatc     1320
aacaaggtca cggtcctcgg cggcaacaat gcggatatca acgctcccta tggttatctg     1380
aaggtccccg gtgacctcaa cagaggtgct ggcggcaact tcatctatgc ctgtaccttc     1440
gtaggcaag                                                             1449

<210>  218
<211>  1449
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  218
atggaaaaca tagacttgcc acaaggactt gtaaactttt ccacgcaaca cctgcaactt       60
attcgtttta aagcaggttt gaatgaaacc gtactacctg gcgtcgaagc cattggactt      120
ggctataacc cattcatcag ttatgccagt gtcaacagcg gcgcggtgca attgttcgac      180
tgggccacgg ccaagaaacg cgaagtgcct ttcaaagccg gctacttcgt acccgagctc      240
gtcgacgtgc aacagaacga cagcgcaacc tacaccaacg tcagcggcaa cacgatcagc      300
gagtaccagc gcagtctggc taccagcgtc gccatcgaag gccgttacaa cttcttcagt      360
ggctcgctgt ccacggattt cgacagtaat tcactgcgca acgcggaaaa cgagttcact      420
cgcattcagc aatcgatcaa cctctggtcg ttgcgcttgc cttcggtgaa gtcattgcgc      480
gaactgatgc tgccacacat gcgccaacaa ctagatgaat tgaacgtcaa cgacccgaag      540
gccataagcc gctatttcga tagagttggc agccatttcc ttaccggcat cgtaatgggt      600
ggacgggcca tcctcgcctc ctcgaccaac aagctcaggg tcaagcgtga ctactcggtg      660
tcggtggtcg ccaaggcgag ctacgaaggg cttaccggcc agttgagcgc agaagccaaa      720
gccaagtatg gcgagtcgat cagcagcttc actcagtact ccaataccca ccaggaagtg      780
cgcggcggcg acggtgccaa ggcacatggg gtgttcagcg gcaaaaaaga agatttccag      840
gcctgggtag acagtgtgag cgcctcgccg gacttcgtcg atttcgtccc caccatcccc      900
atgcaggaaa tctggaccct gtgcagcagc gaggcgcagg ccgaggccat gcgcaagcat      960
tacgatgacg tctgggcgcc ggcgcaatcg gaaaagttcc gggtcaaggc taactacatc     1020
gaccaactgg tggtcatcac cggcggtagt tcaaccatcg aaccaccggt cggctacagc     1080
aagctcgagt acgacctcaa tgccggtgcc ggcggtgact tcatctactt gtgctatcac     1140
gaacaaacct ggcaggccga caggcctaaa gatgctgtga cggatatcag gatcattttc     1200
aacaaggagc ctaccccacc tggctatacc aagctgcccc aggacctgaa caagggcgcg     1260
ggcggtgatg atgtattcct ctgctacaag accgaggctt acaacaccga caccgcaatc     1320
aacaaggtca cggtcatcgg cggcaacaat gcggatatca acgctcccta tggttatctg     1380
aaggtccccg gtgacctcaa cagaggtgct ggcggcaact tcatctatgc ctgtaccttc     1440
gtaggcaag                                                             1449

<210>  219
<211>  1449
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  219
atggaaaaca tagacttgcc acaaggactt gtaaactttt ccacgcaaca cctgcaactt       60
attcgtttta aagcaggttt gaatgaaacc gtactacctg gcgtcgaagc cattggactt      120
ggctataacc cattcatcag ttatgccagt gtcaacagcg gcgcggtgca attgttcgac      180
tgggccacgg ccaagaaacg cgaagtgcct ttcaaagccg gctacttcgt acccgagctc      240
gtcgacgtgc aacagaacga cagcgcaacc ttcaccaacg tcagcggcaa cacgatcagc      300
gagtaccagc gcagtctggc taccagcgtc gccatcgaag gccgttacaa cttcttcagt      360
ggctcgctgt ccacggattt cgacagtaat tcactgcgca acgcggaaaa cgagttcact      420
cgcattcagc aatcgatcaa cctctggtcg ttgcgcttgc cttcggtgaa gtcattgcgc      480
gaactgatgc tgccacacat gcgccaacaa ctagatgaat tgaacgtcaa cgacccgaag      540
gccataagcc gctatttcga tagagttggc agccatttcc ttaccggcat cgtaatgggt      600
ggacgggcca tcctcgcctc ctcgaccaac aagctcaggg tcaagcgtga ctactcggtg      660
tcggtggtcg ccaaggcgag ctacgaaggg cttaccggcc agttgagcgc agaagccaaa      720
gccaagtatg gcgagtcgat cagcagcttc actcagtact ccaataccca ccaggaagtg      780
cgcggcggcg acggtgccaa ggcacatggg gtgttcagcg gcaaaaaaga agatttccag      840
gcctgggtag acagtgtgag cgcctcgccg gacttcgtcg atttcgtccc caccatcccc      900
atgcaggaaa tctggaccct gtgcagcagc gaggcgcagg ccgaggccat gcgcaagcat      960
tacgatgacg tctgggcgcc ggcgcaatcg gaaaagttcc gggtcaaggc taactacatc     1020
gaccaactgg tggtcatcac cggcggtagt tcaaccatcg aaccaccggt cggctacagc     1080
aagatcgagt acgacctcaa tgccggtgcc ggcggtgact tcatctactt gtgctatcac     1140
gaacaaacct ggcaggccga caggcctaaa gatgctgtga cggatatcag gatcattttc     1200
aacaaggagc ctaccccacc tggctatacc aagctgcccc aggacctgaa caagggcgcg     1260
ggcggtgatg atgtattcct ctgctacaag accgaggctt acaacaccga caccgcactc     1320
aacaaggtca cggtcatcgg cggcaacaat gcggatatca acgctcccta tggttatctg     1380
aaggtccccg gtgacctcaa cagaggtgct ggcggcaact tcatctatgc ctgtaccttc     1440
gtaggcaag                                                             1449

<210>  220
<211>  1449
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  220
atggaaaaca tagacttgcc acaaggactt gtaaactttt ccacgcaaca cctgcaactt       60
attcgtttta aagcaggttt gaatgaaacc gtactacctg gcgtcgaagc cattggactt      120
ggctataacc cattcatcag ttatgccagt gtcaacagcg gcgcggtgca attgttcgac      180
tgggccacgg ccaagaaacg cgaagtgcct ttcaaagccg gctacttcgt acccgagctc      240
gtcgacgtgc aacagaacga cagcgcaacc ttcaccaacg tcagcggcaa cacgctcagc      300
gagtaccagc gcagtctggc taccagcgtc gccatcgaag gccgttacaa cttcttcagt      360
ggctcgctgt ccacggattt cgacagtaat tcactgcgca acgcggaaaa cgagttcact      420
cgcattcagc aatcgatcaa cctctggtcg ttgcgcttgc cttcggtgaa gtcattgcgc      480
gaactgatgc tgccacacat gcgccaacaa ctagatgaat tgaacgtcaa cgacccgaag      540
gccataagcc gctatttcga tagagttggc agccatttcc ttaccggcat cgtaatgggt      600
ggacgggcca tcctcgcctc ctcgaccaac aagctcaggg tcaagcgtga ctactcggtg      660
tcggtggtcg ccaaggcgag ctacgaaggg cttaccggcc agttgagcgc agaagccaaa      720
gccaagtatg gcgagtcgat cagcagcttc actcagtact ccaataccca ccaggaagtg      780
cgcggcggcg acggtgccaa ggcacatggg gtgttcagcg gcaaaaaaga agatttccag      840
gcctgggtag acagtgtgag cgcctcgccg gacttcgtcg atttcgtccc caccatcccc      900
atgcaggaaa tctggaccct gtgcagcagc gaggcgcagg ccgaggccat gcgcaagcat      960
ttcgatgacg tctgggcgcc ggcgcaatcg gaaaagttcc gggtcaaggc taactacatc     1020
gaccaactgg tggtcatcac cggcggtagt tcaaccatcg aaccaccggt cggctacagc     1080
aagatcgagt acgacctcaa tgccggtgcc ggcggtgact tcatctactt gtgctatcac     1140
gaacaaacct ggcaggccga caggcctaaa gatgctgtga cggatatcag gatcattttc     1200
aacaaggagc ctaccccacc tggctatacc aagctgcccc aggacctgaa caagggcgcg     1260
ggcggtgatg atgtattcct ctgctacaag accgaggctt acaacaccga caccgcaatc     1320
aacaaggtca cggtcatcgg cggcaacaat gcggatatca acgctcccta tggttatctg     1380
aaggtccccg gtgacctcaa cagaggtgct ggcggcaact tcatctatgc ctgtaccttc     1440
gtaggcaag                                                             1449

<210>  221
<211>  1008
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  221
atggaaaaca tagacttgcc acaaggactt gtaaactttt ccacgcaaca cctgcaactt       60
attcgtttta aagcaggttt gaatgaaacc gtactacctg gcgtcgaagc cattggactt      120
ggctataacc cattcatcag ttatgccagt gtcaacagcg gcgcggtgca attgttcgac      180
tgggccacgg ccaagaaacg cgaagtgcct ttcaaagccg gctacttcgt acccgagctc      240
gtcgacgtgc aacagaacga cagcgcaacc tacaccaacg tcagcggcaa cacgctcagc      300
gagtaccagc gcagtctggc taccagcgtc gccatcgaag gccgttacaa cttcttcagt      360
ggctcgctgt ccacggattt cgacagtaat tcactgcgca acgcggaaaa cgagttcact      420
cgcattcagc aatcgatcaa cctctggtcg ttgcgcttgc cttcggtgaa gtcattgcgc      480
gaactgatgc tgccacacat gcgccaacaa ctagatgaat tgaacgtcaa cgacccgaag      540
gccataagcc gctatttcga tagagttggc agccatttcc ttaccggcat cgtaatgggt      600
ggacgggcca tcctcgcctc ctcgaccaac aagctcaggg tcaagcgtga ctactcggtg      660
tcggtggtcg ccaaggcgag ctacgaaggg cttaccggcc agttgagcgc agaagccaaa      720
gccaagtatg gcgagtcgat cagcagcttc actcagtact ccaataccca ccaggaagtg      780
cgcggcggcg acggtgccaa ggcacatggg gtgttcagcg gcaaaaaaga agatttccag      840
gcctgggtag acagtgtgag cgcctcgccg gacttcgtcg atttcgtccc caccatcccc      900
atgcaggaaa tctggaccct gtgcagcagc gaggcgcagg ccgaggccat gcgcaagcat      960
tacgatgacg tctgggcgcc ggcgcaatcg aaagttccgg gtcaaggc                  1008

<210>  222
<211>  1449
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  222
atggaaaaca tagacttgcc acaaggactt gtaaactttt ccacgcaaca cctgcaactt       60
attcgtttta aagcaggttt gaatgaaacc gtactacctg gcgtcgaagc cattggactt      120
ggctataacc cattcatcag ttatgccagt gtcaacagcg gcgcggtgca attgttcgac      180
tgggccacgg ccaagaaacg cgaagtgcct ttcaaagccg gctacttcgt acccgagatc      240
gtcgacgtgc aacagaacga cagcgcaacc tacaccaacg tcagcggcaa cacgatcagc      300
gagtaccagc gcagtctggc taccagcgtc gccatcgaag gccgttacaa cttcttcagt      360
ggctcgctgt ccacggattt cgacagtaat tcactgcgca acgcggaaaa cgagttcact      420
cgcattcagc aatcgatcaa cctctggtcg ttgcgcttgc cttcggtgaa gtcattgcgc      480
gaactgatgc tgccacacat gcgccaacaa ctagatgaat tgaacgtcaa cgacccgaag      540
gccataagcc gctatttcga tagagttggc agccatttcc ttaccggcat cgtaatgggt      600
ggacgggcca tcctcgcctc ctcgaccaac aagctcaggg tcaagcgtga ctactcggtg      660
tcggtggtcg ccaaggcgag ctacgaaggg cttaccggcc agttgagcgc agaagccaaa      720
gccaagtatg gcgagtcgat cagcagcttc actcagtact ccaataccca ccaggaagtg      780
cgcggcggcg acggtgccaa ggcacatggg gtgttcagcg gcaaaaaaga agatttccag      840
gcctgggtag acagtgtgag cgcctcgccg gacttcgtcg atttcgtccc caccatcccc      900
atgcaggaaa tctggaccct gtgcagcagc gaggcgcagg ccgaggccat gcgcaagcat      960
tacgatgacg tctgggcgcc ggcgcaatcg gaaaagtacc gggtcaaggc taactacatc     1020
gaccaactgg tggtcatcac cggcggtagt tcaaccatcg aaccaccggt cggctacagc     1080
aagctcgagt acgacctcaa tgccggtgcc ggcggtgact tcatctactt gtgctatcac     1140
gaacaaacct ggcaggccga caggcctaaa gatgctgtga cggatatcag gatcattttc     1200
aacaaggagc ctaccccacc tggctatacc aagctgcccc aggacctgaa caagggcgcg     1260
ggcggtgatg atgtattcct ctgctacaag accgaggctt acaacaccga caccgcactc     1320
aacaaggtca cggtcatcgg cggcaacaat gcggatatca acgctcccta tggttatctg     1380
aaggtccccg gtgacctcaa cagaggtgct ggcggcaact tcatctatgc ctgtaccttc     1440
gtaggcaag                                                             1449

<210>  223
<211>  1449
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  223
atggaaaaca tagacttgcc acaaggactt gtaaactttt ccacgcaaca cctgcaactt       60
attcgtttta aagcaggttt gaatgaaacc gtactacctg gcgtcgaagc cattggactt      120
ggctataacc cattcatcag ttatgccagt gtcaacagcg gcgcggtgca attgttcgac      180
tgggccacgg ccaagaaacg cgaagtgcct ttcaaagccg gctacttcgt acccgagctc      240
gtcgacgtgc aacagaacga cagcgcaacc ttcaccaacg tcagcggcaa cacgatcagc      300
gagtaccagc gcagtctggc taccagcgtc gccatcgaag gccgttacaa cttcttcagt      360
ggctcgctgt ccacggattt cgacagtaat tcactgcgca acgcggaaaa cgagttcact      420
cgcattcagc aatcgatcaa cctctggtcg ttgcgcttgc cttcggtgaa gtcattgcgc      480
gaactgatgc tgccacacat gcgccaacaa ctagatgaat tgaacgtcaa cgacccgaag      540
gccataagcc gctatttcga tagagttggc agccatttcc ttaccggcat cgtaatgggt      600
ggacgggcca tcctcgcctc ctcgaccaac aagctcaggg tcaagcgtga ctactcggtg      660
tcggtggtcg ccaaggcgag ctacgaaggg cttaccggcc agttgagcgc agaagccaaa      720
gccaagtatg gcgagtcgat cagcagcttc actcagtact ccaataccca ccaggaagtg      780
cgcggcggcg acggtgccaa ggcacatggg gtgttcagcg gcaaaaaaga agatttccag      840
gcctgggtag acagtgtgag cgcctcgccg gacttcgtcg atttcgtccc caccatcccc      900
atgcaggaaa tctggaccct gtgcagcagc gaggcgcagg ccgaggccat gcgcaagcat      960
tacgatgacg tctgggcgcc ggcgcaatcg gaaaagttcc gggtcaaggc taactacatc     1020
gaccaactgg tggtcatcac cggcggtagt tcaaccatcg aaccaccggt cggctacagc     1080
aagctcgagt acgacctcaa tgccggtgcc ggcggtgact tcatctactt gtgctatcac     1140
gaacaaacct ggcaggccga caggcctaaa gatgctgtga cggatatcag gatcattttc     1200
aacaaggagc ctaccccacc tggctatacc aagctgcccc aggacctgaa caagggcgcg     1260
ggcggtgatg atgtattcct ctgctacaag accgaggctt acaacaccga caccgcaatc     1320
aacaaggtca cggtcatcgg cggcaacaat gcggatatca acgctcccta tggttatctg     1380
aaggtccccg gtgacctcaa cagaggtgct ggcggcaact tcatctatgc ctgtaccttc     1440
gtaggcaag                                                             1449

<210>  224
<211>  1449
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  224
atggaaaaca tagacttgcc acaaggactt gtaaactttt ccacgcaaca cctgcaactt       60
attcgtttta aagcaggttt gaatgaaacc gtactacctg gcgtcgaagc cattggactt      120
ggctataacc cattcatcag ttatgccagt gtcaacagcg gcgcggtgca attgttcgac      180
tgggccacgg ccaagaaacg cgaagtgcct ttcaaagccg gctacttcgt acccgagatc      240
gtcgacgtgc aacagaacga cagcgcaacc ttcaccaacg tcagcggcaa cacgatcagc      300
gagtaccagc gcagtctggc taccagcgtc gccatcgaag gccgttacaa cttcttcagt      360
ggctcgctgt ccacggattt cgacagtaat tcactgcgca acgcggaaaa cgagttcact      420
cgcattcagc aatcgatcaa cctctggtcg ttgcgcttgc cttcggtgaa gtcattgcgc      480
gaactgatgc tgccacacat gcgccaacaa ctagatgaat tgaacgtcaa cgacccgaag      540
gccataagcc gctatttcga tagagttggc agccatttcc ttaccggcat cgtaatgggt      600
ggacgggcca tcctcgcctc ctcgaccaac aagctcaggg tcaagcgtga ctactcggtg      660
tcggtggtcg ccaaggcgag ctacgaaggg cttaccggcc agttgagcgc agaagccaaa      720
gccaagtatg gcgagtcgat cagcagcttc actcagtact ccaataccca ccaggaagtg      780
cgcggcggcg acggtgccaa ggcacatggg gtgttcagcg gcaaaaaaga agatttccag      840
gcctgggtag acagtgtgag cgcctcgccg gacttcgtcg atttcgtccc caccatcccc      900
atgcaggaaa tctggaccct gtgcagcagc gaggcgcagg ccgaggccat gcgcaagcat      960
ttcgatgacg tctgggcgcc ggcgcaatcg gaaaagtacc gggtcaaggc taactacatc     1020
gaccaactgg tggtcatcac cggcggtagt tcaaccatcg aaccaccggt cggctacagc     1080
aagatcgagt acgacctcaa tgccggtgcc ggcggtgact tcatctactt gtgctatcac     1140
gaacaaacct ggcaggccga caggcctaaa gatgctgtga cggatatcag gatcattttc     1200
aacaaggagc ctaccccacc tggctatacc aagctgcccc aggacctgaa caagggcgcg     1260
ggcggtgatg atgtattcct ctgctacaag accgaggctt acaacaccga caccgcactc     1320
aacaaggtca cggtcatcgg cggcaacaat gcggatatca acgctcccta tggttatctg     1380
aaggtccccg gtgacctcaa cagaggtgct ggcggcaact tcatctatgc ctgtaccttc     1440
gtaggcaag                                                             1449

<210>  225
<211>  1449
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  225
atggaaaaca tagacttgcc acaaggactt gtaaactttt ccacgcaaca cctgcaactt       60
attcgtttta aagcaggttt gaatgaaacc gtactacctg gcgtcgaagc cattggactt      120
ggctataacc cattcatcag ttatgccagt gtcaacagcg gcgcggtgca attgttcgac      180
tgggccacgg ccaagaaacg cgaagtgcct ttcaaagccg gctacttcgt acccgagctc      240
gtcgacgtgc aacagaacga cagcgcaacc tacaccaacg tcagcggcaa cacgatcagc      300
gagtaccagc gcagtctggc taccagcgtc gccatcgaag gccgttacaa cttcttcagt      360
ggctcgctgt ccacggattt cgacagtaat tcactgcgca acgcggaaaa cgagttcact      420
cgcattcagc aatcgatcaa cctctggtcg ttgcgcttgc cttcggtgaa gtcattgcgc      480
gaactgatgc tgccacacat gcgccaacaa ctagatgaat tgaacgtcaa cgacccgaag      540
gccataagcc gctatttcga tagagttggc agccatttcc ttaccggcat cgtaatgggt      600
ggacgggcca tcctcgcctc ctcgaccaac aagctcaggg tcaagcgtga ctactcggtg      660
tcggtggtcg ccaaggcgag ctacgaaggg cttaccggcc agttgagcgc agaagccaaa      720
gccaagtatg gcgagtcgat cagcagcttc actcagtact ccaataccca ccaggaagtg      780
cgcggcggcg acggtgccaa ggcacatggg gtgttcagcg gcaaaaaaga agatttccag      840
gcctgggtag acagtgtgag cgcctcgccg gacttcgtcg atttcgtccc caccatcccc      900
atgcaggaaa tctggaccct gtgcagcagc gaggcgcagg ccgaggccat gcgcaagcat      960
tacgatgacg tctgggcgcc ggcgcaatcg gaaaagttcc gggtcaaggc taactacatc     1020
gaccaactgg tggtcctcac cggcggtagt tcaaccatcg aaccaccggt cggctacagc     1080
aagatcgagt acgacctcaa tgccggtgcc ggcggtgact tcatctactt gtgctatcac     1140
gaacaaacct ggcaggccga caggcctaaa gatgctgtga cggatatcag gatcattttc     1200
aacaaggagc ctaccccacc tggctatacc aagctgcccc aggacctgaa caagggcgcg     1260
ggcggtgatg atgtattcct ctgctacaag accgaggctt tcaacaccga caccgcactc     1320
aacaaggtca cggtcatcgg cggcaacaat gcggatatca acgctcccta tggttatctg     1380
aaggtccccg gtgacctcaa cagaggtgct ggcggcaact tcatctatgc ctgtaccttc     1440
gtaggcaag                                                             1449

<210>  226
<211>  1449
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  226
atggaaaaca tagacttgcc acaaggactt gtaaactttt ccacgcaaca cctgcaactt       60
attcgtttta aagcaggttt gaatgaaacc gtactacctg gcgtcgaagc cattggactt      120
ggctataacc cattcatcag ttatgccagt gtcaacagcg gcgcggtgca attgttcgac      180
tgggccacgg ccaagaaacg cgaagtgcct ttcaaagccg gctacttcgt acccgagctc      240
gtcgacgtgc aacagaacga cagcgcaacc tacaccaacg tcagcggcaa cacgctcagc      300
gagtaccagc gcagtctggc taccagcgtc gccatcgaag gccgttacaa cttcttcagt      360
ggctcgctgt ccacggattt cgacagtaat tcactgcgca acgcggaaaa cgagttcact      420
cgcattcagc aatcgatcaa cctctggtcg ttgcgcttgc cttcggtgaa gtcattgcgc      480
gaactgatgc tgccacacat gcgccaacaa ctagatgaat tgaacgtcaa cgacccgaag      540
gccataagcc gctatttcga tagagttggc agccatttcc ttaccggcat cgtaatgggt      600
ggacgggcca tcctcgcctc ctcgaccaac aagctcaggg tcaagcgtga ctactcggtg      660
tcggtggtcg ccaaggcgag ctacgaaggg cttaccggcc agttgagcgc agaagccaaa      720
gccaagtatg gcgagtcgat cagcagcttc actcagtact ccaataccca ccaggaagtg      780
cgcggcggcg acggtgccaa ggcacatggg gtgttcagcg gcaaaaaaga agatttccag      840
gcctgggtag acagtgtgag cgcctcgccg gacttcgtcg atttcgtccc caccatcccc      900
atgcaggaaa tctggaccct gtgcagcagc gaggcgcagg ccgaggccat gcgcaagcat      960
ttcgatgacg tctgggcgcc ggcgcaatcg gaaaagttcc gggtcaaggc taactacatc     1020
gaccaactgg tggtcatcac cggcggtagt tcaaccatcg aaccaccggt cggctacagc     1080
aagctcgagt acgacctcaa tgccggtgcc ggcggtgact tcatctactt gtgctatcac     1140
gaacaaacct ggcaggccga caggcctaaa gatgctgtga cggatatcag gatcattttc     1200
aacaaggagc ctaccccacc tggctatacc aagctgcccc aggacctgaa caagggcgcg     1260
ggcggtgatg atgtattcct ctgctacaag accgaggctt acaacaccga caccgcactc     1320
aacaaggtca cggtcatcgg cggcaacaat gcggatatca acgctcccta tggttatctg     1380
aaggtccccg gtgacctcaa cagaggtgct ggcggcaact tcatctatgc ctgtaccttc     1440
gtaggcaag                                                             1449

<210>  227
<211>  1449
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  227
atggaaaaca tagacttgcc acaaggactt gtaaactttt ccacgcaaca cctgcaactt       60
attcgtttta aagcaggttt gaatgaaacc gtactacctg gcgtcgaagc cattggactt      120
ggctataacc cattcatcag ttatgccagt gtcaacagcg gcgcggtgca attgttcgac      180
tgggccacgg ccaagaaacg cgaagtgcct ttcaaagccg gctacttcgt acccgagctc      240
gtcgacgtgc aacagaacga cagcgcaacc tacaccaacg tcagcggcaa cacgatcagc      300
gagtaccagc gcagtctggc taccagcgtc gccatcgaag gccgttacaa cttcttcagt      360
ggctcgctgt ccacggattt cgacagtaat tcactgcgca acgcggaaaa cgagttcact      420
cgcattcagc aatcgatcaa cctctggtcg ttgcgcttgc cttcggtgaa gtcattgcgc      480
gaactgatgc tgccacacat gcgccaacaa ctagatgaat tgaacgtcaa cgacccgaag      540
gccataagcc gctatttcga tagagttggc agccatttcc ttaccggcat cgtaatgggt      600
ggacgggcca tcctcgcctc ctcgaccaac aagctcaggg tcaagcgtga ctactcggtg      660
tcggtggtcg ccaaggcgag ctacgaaggg cttaccggcc agttgagcgc agaagccaaa      720
gccaagtatg gcgagtcgat cagcagcttc actcagtact ccaataccca ccaggaagtg      780
cgcggcggcg acggtgccaa ggcacatggg gtgttcagcg gcaaaaaaga agatttccag      840
gcctgggtag acagtgtgag cgcctcgccg gacttcgtcg atttcgtccc caccatcccc      900
atgcaggaaa tctggaccct gtgcagcagc gaggcgcagg ccgaggccat gcgcaagcat      960
tacgatgacg tctgggcgcc ggcgcaatcg gaaaagtacc gggtcaaggc taacttcatc     1020
gaccaactgg tggtcatcac cggcggtagt tcaaccatcg aaccaccggt cggctacagc     1080
aagatcgagt acgacctcaa tgccggtgcc ggcggtgact tcatctactt gtgctatcac     1140
gaacaaacct ggcaggccga caggcctaaa gatgctgtga cggatatcag gatcattttc     1200
aacaaggagc ctaccccacc tggctatacc aagctgcccc aggacctgaa caagggcgcg     1260
ggcggtgatg atgtattcct ctgctacaag accgaggctt acaacaccga caccgcaatc     1320
aacaaggtca cggtcatcgg cggcaacaat gcggatatca acgctcccta tggttatctg     1380
aaggtccccg gtgacctcaa cagaggtgct ggcggcaact tcatctatgc ctgtaccttc     1440
gtaggcaag                                                             1449

<210>  228
<211>  1449
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  228
atggaaaaca tagacttgcc acaaggactt gtaaactttt ccacgcaaca cctgcaactt       60
attcgtttta aagcaggttt gaatgaaacc gtactacctg gcgtcgaagc cattggactt      120
ggctataacc cattcatcag ttatgccagt gtcaacagcg gcgcggtgca attgttcgac      180
tgggccacgg ccaagaaacg cgaagtgcct ttcaaagccg gctacttcgt acccgagctc      240
gtcgacgtgc aacagaacga cagcgcaacc tacaccaacg tcagcggcaa cacgctcagc      300
gagtaccagc gcagtctggc taccagcgtc gccatcgaag gccgttacaa cttcttcagt      360
ggctcgctgt ccacggattt cgacagtaat tcactgcgca acgcggaaaa cgagttcact      420
cgcattcagc aatcgatcaa cctctggtcg ttgcgcttgc cttcggtgaa gtcattgcgc      480
gaactgatgc tgccacacat gcgccaacaa ctagatgaat tgaacgtcaa cgacccgaag      540
gccataagcc gctatttcga tagagttggc agccatttcc ttaccggcat cgtaatgggt      600
ggacgggcca tcctcgcctc ctcgaccaac aagctcaggg tcaagcgtga ctactcggtg      660
tcggtggtcg ccaaggcgag ctacgaaggg cttaccggcc agttgagcgc agaagccaaa      720
gccaagtatg gcgagtcgat cagcagcttc actcagtact ccaataccca ccaggaagtg      780
cgcggcggcg acggtgccaa ggcacatggg gtgttcagcg gcaaaaaaga agatttccag      840
gcctgggtag acagtgtgag cgcctcgccg gacttcgtcg atttcgtccc caccatcccc      900
atgcaggaaa tctggaccct gtgcagcagc gaggcgcagg ccgaggccat gcgcaagcat      960
tacgatgacg tctgggcgcc ggcgcaatcg gaaaagttcc gggtcaaggc taactacatc     1020
gaccaactgg tggtcatcac cggcggtagt tcaaccctcg aaccaccggt cggctacagc     1080
aagatcgagt acgacctcaa tgccggtgcc ggcggtgact tcatctactt gtgctatcac     1140
gaacaaacct ggcaggccga caggcctaaa gatgctgtga cggatatcag gatcattttc     1200
aacaaggagc ctaccccacc tggctatacc aagctgcccc aggacctgaa caagggcgcg     1260
ggcggtgatg atgtattcct ctgctacaag accgaggctt tcaacaccga caccgcaatc     1320
aacaaggtca cggtcctcgg cggcaacaat gcggatatca acgctcccta tggttatctg     1380
aaggtccccg gtgacctcaa cagaggtgct ggcggcaact tcatctatgc ctgtaccttc     1440
gtaggcaag                                                             1449

<210>  229
<211>  1449
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  229
atggaaaaca tagacttgcc acaaggactt gtaaactttt ccacgcaaca cctgcaactt       60
attcgtttta aagcaggttt gaatgaaacc gtactacctg gcgtcgaagc cattggactt      120
ggctataacc cattcatcag ttatgccagt gtcaacagcg gcgcggtgca attgttcgac      180
tgggccacgg ccaagaaacg cgaagtgcct ttcaaagccg gctacttcgt acccgagctc      240
gtcgacgtgc aacagaacga cagcgcaacc tacaccaacg tcagcggcaa cacgatcagc      300
gagtaccagc gcagtctggc taccagcgtc gccatcgaag gccgttacaa cttcttcagt      360
ggctcgctgt ccacggattt cgacagtaat tcactgcgca acgcggaaaa cgagttcact      420
cgcattcagc aatcgatcaa cctctggtcg ttgcgcttgc cttcggtgaa gtcattgcgc      480
gaactgatgc tgccacacat gcgccaacaa ctagatgaat tgaacgtcaa cgacccgaag      540
gccataagcc gctatttcga tagagttggc agccatttcc ttaccggcat cgtaatgggt      600
ggacgggcca tcctcgcctc ctcgaccaac aagctcaggg tcaagcgtga ctactcggtg      660
tcggtggtcg ccaaggcgag ctacgaaggg cttaccggcc agttgagcgc agaagccaaa      720
gccaagtatg gcgagtcgat cagcagcttc actcagtact ccaataccca ccaggaagtg      780
cgcggcggcg acggtgccaa ggcacatggg gtgttcagcg gcaaaaaaga agatttccag      840
gcctgggtag acagtgtgag cgcctcgccg gacttcgtcg atttcgtccc caccatcccc      900
atgcaggaaa tctggaccct gtgcagcagc gaggcgcagg ccgaggccat gcgcaagcat      960
tacgatgacg tctgggcgcc ggcgcaatcg gaaaagttcc gggtcaaggc taactacatc     1020
gaccaactgg tggtcatcac cggcggtagt tcaaccatcg aaccaccggt cggctacagc     1080
aagatcgagt acgacctcaa tgccggtgcc ggcggtgact tcatctactt gtgctatcac     1140
gaacaaacct ggcaggccga caggcctaaa gatgctgtga cggatatcag gatcattttc     1200
aacaaggagc ctaccccacc tggctatacc aagctgcccc aggacctgaa caagggcgcg     1260
ggcggtgatg atgtattcct ctgctacaag accgaggctt acaacaccga caccgcactc     1320
aacaaggtca cggtcatcgg cggcaacaat gcggatatca acgctcccta tggttatctg     1380
aaggtccccg gtgacctcaa cagaggtgct ggcggcaact tcatctatgc ctgtaccttc     1440
gtaggcaag                                                             1449

<210>  230
<211>  1449
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  230
atggaaaaca tagacttgcc acaaggactt gtaaactttt ccacgcaaca cctgcaactt       60
attcgtttta aagcaggttt gaatgaaacc gtactacctg gcgtcgaagc cattggactt      120
ggctataacc cattcatcag ttatgccagt gtcaacagcg gcgcggtgca attgttcgac      180
tgggccacgg ccaagaaacg cgaagtgcct ttcaaagccg gctacttcgt acccgagctc      240
gtcgacgtgc aacagaacga cagcgcaacc ttcaccaacg tcagcggcaa cacgatcagc      300
gagtaccagc gcagtctggc taccagcgtc gccatcgaag gccgttacaa cttcttcagt      360
ggctcgctgt ccacggattt cgacagtaat tcactgcgca acgcggaaaa cgagttcact      420
cgcattcagc aatcgatcaa cctctggtcg ttgcgcttgc cttcggtgaa gtcattgcgc      480
gaactgatgc tgccacacat gcgccaacaa ctagatgaat tgaacgtcaa cgacccgaag      540
gccataagcc gctatttcga tagagttggc agccatttcc ttaccggcat cgtaatgggt      600
ggacgggcca tcctcgcctc ctcgaccaac aagctcaggg tcaagcgtga ctactcggtg      660
tcggtggtcg ccaaggcgag ctacgaaggg cttaccggcc agttgagcgc agaagccaaa      720
gccaagtatg gcgagtcgat cagcagcttc actcagtact ccaataccca ccaggaagtg      780
cgcggcggcg acggtgccaa ggcacatggg gtgttcagcg gcaaaaaaga agatttccag      840
gcctgggtag acagtgtgag cgcctcgccg gacttcgtcg atttcgtccc caccatcccc      900
atgcaggaaa tctggaccct gtgcagcagc gaggcgcagg ccgaggccat gcgcaagcat      960
tacgatgacg tctgggcgcc ggcgcaatcg gaaaagttcc gggtcaaggc taactacatc     1020
gaccaactgg tggtcctcac cggcggtagt tcaaccatcg aaccaccggt cggctacagc     1080
aagatcgagt acgacctcaa tgccggtgcc ggcggtgact tcatctactt gtgctatcac     1140
gaacaaacct ggcaggccga caggcctaaa gatgctgtga cggatatcag gatcattttc     1200
aacaaggagc ctaccccacc tggctatacc aagctgcccc aggacctgaa caagggcgcg     1260
ggcggtgatg atgtattcct ctgctacaag accgaggctt acaacaccga caccgcactc     1320
aacaaggtca cggtcatcgg cggcaacaat gcggatatca acgctccctt tggttatctg     1380
aaggtccccg gtgacctcaa cagaggtgct ggcggcaact tcatctatgc ctgtaccttc     1440
gtaggcaag                                                             1449

<210>  231
<211>  1449
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  231
atggaaaaca tagacttgcc acaaggactt gtaaactttt ccacgcaaca cctgcaactt       60
attcgtttta aagcaggttt gaatgaaacc gtactacctg gcgtcgaagc cattggactt      120
ggctataacc cattcatcag ttatgccagt gtcaacagcg gcgcggtgca attgttcgac      180
tgggccacgg ccaagaaacg cgaagtgcct ttcaaagccg gctacttcgt acccgagctc      240
gtcgacgtgc aacagaacga cagcgcaacc tacaccaacg tcagcggcaa cacgatcagc      300
gagtaccagc gcagtctggc taccagcgtc gccatcgaag gccgttacaa cttcttcagt      360
ggctcgctgt ccacggattt cgacagtaat tcactgcgca acgcggaaaa cgagttcact      420
cgcattcagc aatcgatcaa cctctggtcg ttgcgcttgc cttcggtgaa gtcattgcgc      480
gaactgatgc tgccacacat gcgccaacaa ctagatgaat tgaacgtcaa cgacccgaag      540
gccataagcc gctatttcga tagagttggc agccatttcc ttaccggcat cgtaatgggt      600
ggacgggcca tcctcgcctc ctcgaccaac aagctcaggg tcaagcgtga ctactcggtg      660
tcggtggtcg ccaaggcgag ctacgaaggg cttaccggcc agttgagcgc agaagccaaa      720
gccaagtatg gcgagtcgat cagcagcttc actcagtact ccaataccca ccaggaagtg      780
cgcggcggcg acggtgccaa ggcacatggg gtgttcagcg gcaaaaaaga agatttccag      840
gcctgggtag acagtgtgag cgcctcgccg gacttcgtcg atttcgtccc caccatcccc      900
atgcaggaaa tctggaccct gtgcagcagc gaggcgcagg ccgaggccat gcgcaagcat      960
tacgatgacg tctgggcgcc ggcgcaatcg gaaaagtacc gggtcaaggc taactacctc     1020
gaccaactgg tggtcatcac cggcggtagt tcaaccatcg aaccaccggt cggctacagc     1080
aagctcgagt acgacctcaa tgccggtgcc ggcggtgact tcatctactt gtgctatcac     1140
gaacaaacct ggcaggccga caggcctaaa gatgctgtga cggatatcag gatcattttc     1200
aacaaggagc ctaccccacc tggctatacc aagctgcccc aggacctgaa caagggcgcg     1260
ggcggtgatg atgtattcct ctgctacaag accgaggctt tcaacaccga caccgcaatc     1320
aacaaggtca cggtcatcgg cggcaacaat gcggatatca acgctcccta tggttatctg     1380
aaggtccccg gtgacctcaa cagaggtgct ggcggcaact tcatctatgc ctgtaccttc     1440
gtaggcaag                                                             1449

<210>  232
<211>  1449
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  232
atggaaaaca tagacttgcc acaaggactt gtaaactttt ccacgcaaca cctgcaactt       60
attcgtttta aagcaggttt gaatgaaacc gtactacctg gcgtcgaagc cattggactt      120
ggctataacc cattcatcag ttatgccagt gtcaacagcg gcgcggtgca attgttcgac      180
tgggccacgg ccaagaaacg cgaagtgcct ttcaaagccg gctacttcgt acccgagctc      240
gtcgacgtgc aacagaacga cagcgcaacc tacaccaacg tcagcggcaa cacgatcagc      300
gagtaccagc gcagtctggc taccagcgtc gccatcgaag gccgttacaa cttcttcagt      360
ggctcgctgt ccacggattt cgacagtaat tcactgcgca acgcggaaaa cgagttcact      420
cgcattcagc aatcgatcaa cctctggtcg ttgcgcttgc cttcggtgaa gtcattgcgc      480
gaactgatgc tgccacacat gcgccaacaa ctagatgaat tgaacgtcaa cgacccgaag      540
gccataagcc gctatttcga tagagttggc agccatttcc ttaccggcat cgtaatgggt      600
ggacgggcca tcctcgcctc ctcgaccaac aagctcaggg tcaagcgtga ctactcggtg      660
tcggtggtcg ccaaggcgag ctacgaaggg cttaccggcc agttgagcgc agaagccaaa      720
gccaagtatg gcgagtcgat cagcagcttc actcagtact ccaataccca ccaggaagtg      780
cgcggcggcg acggtgccaa ggcacatggg gtgttcagcg gcaaaaaaga agatttccag      840
gcctgggtag acagtgtgag cgcctcgccg gacttcgtcg atttcgtccc caccatcccc      900
atgcaggaaa tctggaccct gtgcagcagc gaggcgcagg ccgaggccat gcgcaagcat      960
tacgatgacg tctgggcgcc ggcgcaatcg gaaaagtacc gggtcaaggc taactacctc     1020
gaccaactgg tggtcctcac cggcggtagt tcaaccatcg aaccaccggt cggctacagc     1080
aagctcgagt acgacctcaa tgccggtgcc ggcggtgact tcatctactt gtgctatcac     1140
gaacaaacct ggcaggccga caggcctaaa gatgctgtga cggatatcag gatcattttc     1200
aacaaggagc ctaccccacc tggctatacc aagctgcccc aggacctgaa caagggcgcg     1260
ggcggtgatg atgtattcct ctgctacaag accgaggctt tcaacaccga caccgcaatc     1320
aacaaggtca cggtcatcgg cggcaacaat gcggatatca acgctcccta tggttatctg     1380
aaggtccccg gtgacctcaa cagaggtgct ggcggcaact tcatctatgc ctgtaccttc     1440
gtaggcaag                                                             1449

<210>  233
<211>  1449
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  233
atggaaaaca tagacttgcc acaaggactt gtaaactttt ccacgcaaca cctgcaactt       60
attcgtttta aagcaggttt gaatgaaacc gtactacctg gcgtcgaagc cattggactt      120
ggctataacc cattcatcag ttatgccagt gtcaacagcg gcgcggtgca attgttcgac      180
tgggccacgg ccaagaaacg cgaagtgcct ttcaaagccg gctacttcgt acccgagctc      240
gtcgacgtgc aacagaacga cagcgcaacc tacaccaacg tcagcggcaa cacgctcagc      300
gagtaccagc gcagtctggc taccagcgtc gccatcgaag gccgttacaa cttcttcagt      360
ggctcgctgt ccacggattt cgacagtaat tcactgcgca acgcggaaaa cgagttcact      420
cgcattcagc aatcgatcaa cctctggtcg ttgcgcttgc cttcggtgaa gtcattgcgc      480
gaactgatgc tgccacacat gcgccaacaa ctagatgaat tgaacgtcaa cgacccgaag      540
gccataagcc gctatttcga tagagttggc agccatttcc ttaccggcat cgtaatgggt      600
ggacgggcca tcctcgcctc ctcgaccaac aagctcaggg tcaagcgtga ctactcggtg      660
tcggtggtcg ccaaggcgag ctacgaaggg cttaccggcc agttgagcgc agaagccaaa      720
gccaagtatg gcgagtcgat cagcagcttc actcagtact ccaataccca ccaggaagtg      780
cgcggcggcg acggtgccaa ggcacatggg gtgttcagcg gcaaaaaaga agatttccag      840
gcctgggtag acagtgtgag cgcctcgccg gacttcgtcg atttcgtccc caccatcccc      900
atgcaggaaa tctggaccct gtgcagcagc gaggcgcagg ccgaggccat gcgcaagcat      960
tacgatgacg tctgggcgcc ggcgcaatcg gaaaagttcc gggtcaaggc taactacatc     1020
gaccaactgg tggtcatcac cggcggtagt tcaaccctcg aaccaccggt cggctacagc     1080
aagatcgagt acgacctcaa tgccggtgcc ggcggtgact tcatctactt gtgctatcac     1140
gaacaaacct ggcaggccga caggcctaaa gatgctgtga cggatatcag gatcattttc     1200
aacaaggagc ctaccccacc tggctatacc aagctgcccc aggacctgaa caagggcgcg     1260
ggcggtgatg atgtattcct ctgctacaag accgaggctt acaacaccga caccgcaatc     1320
aacaaggtca cggtcatcgg cggcaacaat gcggatatca acgctcccta tggttatctg     1380
aaggtccccg gtgacctcaa cagaggtgct ggcggcaact tcatctatgc ctgtaccttc     1440
gtaggcaag                                                             1449

<210>  234
<211>  1449
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  234
atggaaaaca tagacttgcc acaaggactt gtaaactttt ccacgcaaca cctgcaactt       60
attcgtttta aagcaggttt gaatgaaacc gtactacctg gcgtcgaagc cattggactt      120
ggctataacc cattcatcag ttatgccagt gtcaacagcg gcgcggtgca attgttcgac      180
tgggccacgg ccaagaaacg cgaagtgcct ttcaaagccg gctacttcgt acccgagctc      240
gtcgacgtgc aacagaacga cagcgcaacc tacaccaacg tcagcggcaa cacgctcagc      300
gagtaccagc gcagtctggc taccagcgtc gccatcgaag gccgttacaa cttcttcagt      360
ggctcgctgt ccacggattt cgacagtaat tcactgcgca acgcggaaaa cgagttcact      420
cgcattcagc aatcgatcaa cctctggtcg ttgcgcttgc cttcggtgaa gtcattgcgc      480
gaactgatgc tgccacacat gcgccaacaa ctagatgaat tgaacgtcaa cgacccgaag      540
gccataagcc gctatttcga tagagttggc agccatttcc ttaccggcat cgtaatgggt      600
ggacgggcca tcctcgcctc ctcgaccaac aagctcaggg tcaagcgtga ctactcggtg      660
tcggtggtcg ccaaggcgag ctacgaaggg cttaccggcc agttgagcgc agaagccaaa      720
gccaagtatg gcgagtcgat cagcagcttc actcagtact ccaataccca ccaggaagtg      780
cgcggcggcg acggtgccaa ggcacatggg gtgttcagcg gcaaaaaaga agatttccag      840
gcctgggtag acagtgtgag cgcctcgccg gacttcgtcg atttcgtccc caccatcccc      900
atgcaggaaa tctggaccct gtgcagcagc gaggcgcagg ccgaggccat gcgcaagcat      960
tacgatgacg tctgggcgcc ggcgcaatcg gaaaagtacc gggtcaaggc taactacatc     1020
gaccaactgg tggtcctcac cggcggtagt tcaaccatcg aaccaccggt cggctacagc     1080
aagctcgagt acgacctcaa tgccggtgcc ggcggtgact tcatctactt gtgctatcac     1140
gaacaaacct ggcaggccga caggcctaaa gatgctgtga cggatatcag gatcattttc     1200
aacaaggagc ctaccccacc tggctatacc aagctgcccc aggacctgaa caagggcgcg     1260
ggcggtgatg atgtattcct ctgctacaag accgaggctt acaacaccga caccgcactc     1320
aacaaggtca cggtcatcgg cggcaacaat gcggatatca acgctcccta tggttatctg     1380
aaggtccccg gtgacctcaa cagaggtgct ggcggcaact tcatctatgc ctgtaccttc     1440
gtaggcaag                                                             1449

<210>  235
<211>  1176
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  235
atggaaaaca tagacttgcc acaaggactt gtaaactttt ccacgcaaca cctgcaactt       60
attcgtttta aagcaggttt gaatgaaacc gtactacctg gcgtcgaagc cattggactt      120
ggctataacc cattcatcag ttatgccagt gtcaacagcg gcgcggtgca attgttcgac      180
tgggccacgg ccaagaaacg cgaagtgcct ttcaaagccg gctacttcgt acccgagctc      240
gtcgacgtgc aacagaacga cagcgcaacc ttcaccaacg tcagcggcaa cacgctcagc      300
gagtaccagc gcagtctggc taccagcgtc gccatcgaag gccgttacaa cttcttcagt      360
ggctcgctgt ccacggattt cgacagtaat tcactgcgca acgcggaaaa cgagttcact      420
cgcattcagc aatcgatcaa cctctggtcg ttgcgcttgc cttcggtgaa gtcattgcgc      480
gaactgatgc tgccacacat gcgccaacaa ctagatgaat tgaacgtcaa cgacccgaag      540
gccataagcc gctatttcga tagagttggc agccatttcc ttaccggcat cgtaatgggt      600
ggacgggcca tcctcgcctc ctcgaccaac aagctcaggg tcaagcgtga ctactcggtg      660
tcggtggtcg ccaaggcgag ctacgaaggg cttaccggcc agttgagcgc agaagccaaa      720
gccaagtatg gcgagtcgat cagcagcttc actcagtact ccaataccca ccaggaagtg      780
cgcggcggcg acggtgccaa ggcacatggg gtgttcagcg gcaaaaaaga agatttccag      840
gcctgggtag acagtgtgag cgcctcgccg gacttcgtcg atttcgtccc caccatcccc      900
atgcaggaaa tctggaccct gtgcagcagc gaggcgcagg ccgaggccat gcgcaagcat      960
ttcgatgacg tctgggcacc ggcgcaatcg gaaaagttcc gggtcaaggc taactacctc     1020
gaccaactgg tggtcatcac cggcggtatt caaccctcga accaccggtc ggctacagca     1080
agatcgagta cgacctcaat gccggtgccg gcggtgactt catctacttg tgctatcacg     1140
aacaaacctg gcaggccgac aggcctaaag atgctg                               1176

<210>  236
<211>  1377
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  236
atggaaaaca tagacttgcc acaaggactt gtaaactttt ccacgcaaca cctgcaactt       60
attcgtttta aagcaggttt gaatgaaacc gtactacctg gcgtcgaagc cattggactt      120
ggctataacc cattcatcag ttatgccagt gtcaacagcg gcgcggtgca attgttcgac      180
tgggccacgg ccaagaaacg cgaagtgcct ttcaaagccg gctacttcgt acccgagctc      240
gtcgacgtgc aacagaacga cagcgcaacc tacaccaacg tcagcggcaa cacgatcagc      300
gagtaccagc gcagtctggc taccagcgtc gccatcgaag gccgttacaa cttcttcagt      360
ggctcgctgt ccacggattt cgacagtaat tcactgcgca acgcggaaaa cgagttcact      420
cgcattcagc aatcgatcaa cctctggtcg ttgcgcttgc cttcggtgaa gtcattgcgc      480
gaactgatgc tgccacacat gcgccaacaa ctagatgaat tgaacgtcaa cgacccgaag      540
gccataagcc gctatttcga tagagttggc agccatttcc ttaccggcat cgtaatgggt      600
ggacgggcca tcctcgcctc ctcgaccaac aagctcaggg tcaagcgtga ctactcggtg      660
tcggtggtcg ccaaggcgag ctacgaaggg cttaccggcc agttgagcgc agaagccaaa      720
gccaagtatg gcgagtcgat cagcagcttc actcagtact ccaataccca ccaggaagtg      780
cgcggcggcg acggtgccaa ggcacatggg gtgttcagcg gcaaaaaaga agatttccag      840
gcctgggtag acagtgtgag cgcctcgccg gacttcgtcg atttcgtccc caccatcccc      900
atgcaggaaa tctggaccct gtgcagcagc gaggcgcagg ccgaggccat gcgcaagcat      960
tacgatgacg tctgggcgcc ggcgcaatcg gaaaagtacc gggtcaaggc taactacctc     1020
gaccaactgg tggtcatcac cggcggtagt tcaaccatcg aaccaccggt cggctacagc     1080
aagctcgagt acgacctcaa tgccggtgcc ggcggtgact tcatctactt gtgctatcac     1140
gaacaaacct ggcaggccga caggcctaaa gatgctgtga cggatatcag gatcattttc     1200
aacaaggagc ctaccccacc tggctatacc aagctgcccc aggacctgaa caagggcgcg     1260
ggcggtgatg atgtattcct ctgctacaag accgaggctt acaacaccgc accgcactca     1320
acaaggtcac ggtcctcggc ggcaacaatg cggatatcaa cgctcccttt ggttatc        1377

<210>  237
<211>  1449
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  237
atggaaaaca tagacttgcc acaaggactt gtaaactttt ccacgcaaca cctgcaactt       60
attcgtttta aagcaggttt gaatgaaacc gtactacctg gcgtcgaagc cattggactt      120
ggctataacc cattcatcag ttatgccagt gtcaacagcg gcgcggtgca attgttcgac      180
tgggccacgg ccaagaaacg cgaagtgcct ttcaaagccg gctacttcgt acccgagatc      240
gtcgacgtgc aacagaacga cagcgcaacc tacaccaacg tcagcggcaa cacgatcagc      300
gagtaccagc gcagtctggc taccagcgtc gccatcgaag gccgttacaa cttcttcagt      360
ggctcgctgt ccacggattt cgacagtaat tcactgcgca acgcggaaaa cgagttcact      420
cgcattcagc aatcgatcaa cctctggtcg ttgcgcttgc cttcggtgaa gtcattgcgc      480
gaactgatgc tgccacacat gcgccaacaa ctagatgaat tgaacgtcaa cgacccgaag      540
gccataagcc gctatttcga tagagttggc agccatttcc ttaccggcat cgtaatgggt      600
ggacgggcca tcctcgcctc ctcgaccaac aagctcaggg tcaagcgtga ctactcggtg      660
tcggtggtcg ccaaggcgag ctacgaaggg cttaccggcc agttgagcgc agaagccaaa      720
gccaagtatg gcgagtcgat cagcagcttc actcagtact ccaataccca ccaggaagtg      780
cgcggcggcg acggtgccaa ggcacatggg gtgttcagcg gcaaaaaaga agatttccag      840
gcctgggtag acagtgtgag cgcctcgccg gacttcgtcg atttcgtccc caccatcccc      900
atgcaggaaa tctggaccct gtgcagcagc gaggcgcagg ccgaggccat gcgcaagcat      960
tacgatgacg tctgggcgcc ggcgcaatcg gaaaagttcc gggtcaaggc taactacctc     1020
gaccaactgg tggtcatcac cggcggtagt tcaaccatcg aaccaccggt cggctacagc     1080
aagctcgagt acgacctcaa tgccggtgcc ggcggtgact tcatctactt gtgctatcac     1140
gaacaaacct ggcaggccga caggcctaaa gatgctgtga cggatatcag gatcattttc     1200
aacaaggagc ctaccccacc tggctatacc aagctgcccc aggacctgaa caagggcgcg     1260
ggcggtgatg atgtattcct ctgctacaag accgaggctt acaacaccga caccgcaatc     1320
aacaaggtca cggtcatcgg cggcaacaat gcggatatca acgctcccta tggttatctg     1380
aaggtccccg gtgacctcaa cagaggtgct ggcggcaact tcatctatgc ctgtaccttc     1440
gtaggcaag                                                             1449

<210>  238
<211>  1449
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  238
atggaaaaca tagacttgcc acaaggactt gtaaactttt ccacgcaaca cctgcaactt       60
attcgtttta aagcaggttt gaatgaaacc gtactacctg gcgtcgaagc cattggactt      120
ggctataacc cattcatcag ttatgccagt gtcaacagcg gcgcggtgca attgttcgac      180
tgggccacgg ccaagaaacg cgaagtgcct ttcaaagccg gctacttcgt acccgagctc      240
gtcgacgtgc aacagaacga cagcgcaacc ttcaccaacg tcagcggcaa cacgatcagc      300
gagtaccagc gcagtctggc taccagcgtc gccatcgaag gccgttacaa cttcttcagt      360
ggctcgctgt ccacggattt cgacagtaat tcactgcgca acgcggaaaa cgagttcact      420
cgcattcagc aatcgatcaa cctctggtcg ttgcgcttgc cttcggtgaa gtcattgcgc      480
gaactgatgc tgccacacat gcgccaacaa ctagatgaat tgaacgtcaa cgacccgaag      540
gccataagcc gctatttcga tagagttggc agccatttcc ttaccggcat cgtaatgggt      600
ggacgggcca tcctcgcctc ctcgaccaac aagctcaggg tcaagcgtga ctactcggtg      660
tcggtggtcg ccaaggcgag ctacgaaggg cttaccggcc agttgagcgc agaagccaaa      720
gccaagtatg gcgagtcgat cagcagcttc actcagtact ccaataccca ccaggaagtg      780
cgcggcggcg acggtgccaa ggcacatggg gtgttcagcg gcaaaaaaga agatttccag      840
gcctgggtag acagtgtgag cgcctcgccg gacttcgtcg atttcgtccc caccatcccc      900
atgcaggaaa tctggaccct gtgcagcagc gaggcgcagg ccgaggccat gcgcaagcat      960
tacgatgacg tctgggcgcc ggcgcaatcg gaaaagtacc gggtcaaggc taactacctc     1020
gaccaactgg tggtcatcac cggcggtagt tcaaccatcg aaccaccggt cggctacagc     1080
aagatcgagt acgacctcaa tgccggtgcc ggcggtgact tcatctactt gtgctatcac     1140
gaacaaacct ggcaggccga caggcctaaa gatgctgtga cggatatcag gatcattttc     1200
aacaaggagc ctaccccacc tggctatacc aagctgcccc aggacctgaa caagggcgcg     1260
ggcggtgatg atgtattcct ctgctacaag accgaggctt acaacaccga caccgcaatc     1320
aacaaggtca cggtcatcgg cggcaacaat gcggatatca acgctcccta tggttatctg     1380
aaggtccccg gtgacctcaa cagaggtgct ggcggcaact tcatctatgc ctgtaccttc     1440
gtaggcaag                                                             1449

<210>  239
<211>  1449
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  239
atggaaaaca tagacttgcc acaaggactt gtaaactttt ccacgcaaca cctgcaactt       60
attcgtttta aagcaggttt gaatgaaacc gtactacctg gcgtcgaagc cattggactt      120
ggctataacc cattcatcag ttatgccagt gtcaacagcg gcgcggtgca attgttcgac      180
tgggccacgg ccaagaaacg cgaagtgcct ttcaaagccg gctacttcgt acccgagatc      240
gtcgacgtgc aacagaacga cagcgcaacc ttcaccaacg tcagcggcaa cacgatcagc      300
gagtaccagc gcagtctggc taccagcgtc gccatcgaag gccgttacaa cttcttcagt      360
ggctcgctgt ccacggattt cgacagtaat tcactgcgca acgcggaaaa cgagttcact      420
cgcattcagc aatcgatcaa cctctggtcg ttgcgcttgc cttcggtgaa gtcattgcgc      480
gaactgatgc tgccacacat gcgccaacaa ctagatgaat tgaacgtcaa cgacccgaag      540
gccataagcc gctatttcga tagagttggc agccatttcc ttaccggcat cgtaatgggt      600
ggacgggcca tcctcgcctc ctcgaccaac aagctcaggg tcaagcgtga ctactcggtg      660
tcggtggtcg ccaaggcgag ctacgaaggg cttaccggcc agttgagcgc agaagccaaa      720
gccaagtatg gcgagtcgat cagcagcttc actcagtact ccaataccca ccaggaagtg      780
cgcggcggcg acggtgccaa ggcacatggg gtgttcagcg gcaaaaaaga agatttccag      840
gcctgggtag acagtgtgag cgcctcgccg gacttcgtcg atttcgtccc caccatcccc      900
atgcaggaaa tctggaccct gtgcagcagc gaggcgcagg ccgaggccat gcgcaagcat      960
tacgatgacg tctgggcgcc ggcgcaatcg gaaaagttcc gggtcaaggc taactacatc     1020
gaccaactgg tggtcatcac cggcggtagt tcaaccatcg aaccaccggt cggctacagc     1080
aagatcgagt acgacctcaa tgccggtgcc ggcggtgact tcatctactt gtgctatcac     1140
gaacaaacct ggcaggccga caggcctaaa gatgctgtga cggatatcag gatcattttc     1200
aacaaggagc ctaccccacc tggctatacc aagctgcccc aggacctgaa caagggcgcg     1260
ggcggtgatg atgtattcct ctgctacaag accgaggctt acaacaccga caccgcaatc     1320
aacaaggtca cggtcctcgg cggcaacaat gcggatatca acgctcccta tggttatctg     1380
aaggtccccg gtgacctcaa cagaggtgct ggcggcaact tcatctatgc ctgtaccttc     1440
gtaggcaag                                                             1449

<210>  240
<211>  1449
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  240
atggaaaaca tagacttgcc acaaggactt gtaaactttt ccacgcaaca cctgcaactt       60
attcgtttta aagcaggttt gaatgaaacc gtactacctg gcgtcgaagc cattggactt      120
ggctataacc cattcatcag ttatgccagt gtcaacagcg gcgcggtgca attgttcgac      180
tgggccacgg ccaagaaacg cgaagtgcct ttcaaagccg gctacttcgt acccgagctc      240
gtcgacgtgc aacagaacga cagcgcaacc ttcaccaacg tcagcggcaa cacgatcagc      300
gagtaccagc gcagtctggc taccagcgtc gccatcgaag gccgttacaa cttcttcagt      360
ggctcgctgt ccacggattt cgacagtaat tcactgcgca acgcggaaaa cgagttcact      420
cgcattcagc aatcgatcaa cctctggtcg ttgcgcttgc cttcggtgaa gtcattgcgc      480
gaactgatgc tgccacacat gcgccaacaa ctagatgaat tgaacgtcaa cgacccgaag      540
gccataagcc gctatttcga tagagttggc agccatttcc ttaccggcat cgtaatgggt      600
ggacgggcca tcctcgcctc ctcgaccaac aagctcaggg tcaagcgtga ctactcggtg      660
tcggtggtcg ccaaggcgag ctacgaaggg cttaccggcc agttgagcgc agaagccaaa      720
gccaagtatg gcgagtcgat cagcagcttc actcagtact ccaataccca ccaggaagtg      780
cgcggcggcg acggtgccaa ggcacatggg gtgttcagcg gcaaaaaaga agatttccag      840
gcctgggtag acagtgtgag cgcctcgccg gacttcgtcg atttcgtccc caccatcccc      900
atgcaggaaa tctggaccct gtgcagcagc gaggcgcagg ccgaggccat gcgcaagcat      960
tacgatgacg tctgggcgcc ggcgcaatcg gaaaagttcc gggtcaaggc taactacatc     1020
gaccaactgg tggtcatcac cggcggtagt tcaaccatcg aaccaccggt cggctacagc     1080
aagatcgagt acgacctcaa tgccggtgcc ggcggtgact tcatctactt gtgctatcac     1140
gaacaaacct ggcaggccga caggcctaaa gatgctgtga cggatatcag gatcattttc     1200
aacaaggagc ctaccccacc tggctatacc aagctgcccc aggacctgaa caagggcgcg     1260
ggcggtgatg atgtattcct ctgctacaag accgaggctt tcaacaccga caccgcaatc     1320
aacaaggtca cggtcatcgg cggcaacaat gcggatatca acgctcccta tggttatctg     1380
aaggtccccg gtgacctcaa cagaggtgct ggcggcaact tcatctatgc ctgtaccttc     1440
gtaggcaag                                                             1449

<210>  241
<211>  1449
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  241
atggaaaaca tagacttgcc acaaggactt gtaaactttt ccacgcaaca cctgcaactt       60
attcgtttta aagcaggttt gaatgaaacc gtactacctg gcgtcgaagc cattggactt      120
ggctataacc cattcatcag ttatgccagt gtcaacagcg gcgcggtgca attgttcgac      180
tgggccacgg ccaagaaacg cgaagtgcct ttcaaagccg gctacttcgt acccgagatc      240
gtcgacgtgc aacagaacga cagcgcaacc ttcaccaacg tcagcggcaa cacgatcagc      300
gagtaccagc gcagtctggc taccagcgtc gccatcgaag gccgttacaa cttcttcagt      360
ggctcgctgt ccacggattt cgacagtaat tcactgcgca acgcggaaaa cgagttcact      420
cgcattcagc aatcgatcaa cctctggtcg ttgcgcttgc cttcggtgaa gtcattgcgc      480
gaactgatgc tgccacacat gcgccaacaa ctagatgaat tgaacgtcaa cgacccgaag      540
gccataagcc gctatttcga tagagttggc agccatttcc ttaccggcat cgtaatgggt      600
ggacgggcca tcctcgcctc ctcgaccaac aagctcaggg tcaagcgtga ctactcggtg      660
tcggtggtcg ccaaggcgag ctacgaaggg cttaccggcc agttgagcgc agaagccaaa      720
gccaagtatg gcgagtcgat cagcagcttc actcagtact ccaataccca ccaggaagtg      780
cgcggcggcg acggtgccaa ggcacatggg gtgttcagcg gcaaaaaaga agatttccag      840
gcctgggtag acagtgtgag cgcctcgccg gacttcgtcg atttcgtccc caccatcccc      900
atgcaggaaa tctggaccct gtgcagcagc gaggcgcagg ccgaggccat gcgcaagcat      960
tacgatgacg tctgggcgcc ggcgcaatcg gaaaagttcc gggtcaaggc taactacatc     1020
gaccaactgg tggtcatcac cggcggtagt tcaaccatcg aaccaccggt cggctacagc     1080
aagatcgagt acgacctcaa tgccggtgcc ggcggtgact tcatctactt gtgctatcac     1140
gaacaaacct ggcaggccga caggcctaaa gatgctgtga cggatatcag gatcattttc     1200
aacaaggagc ctaccccacc tggctatacc aagctgcccc aggacctgaa caagggcgcg     1260
ggcggtgatg atgtattcct ctgctacaag accgaggctt acaacaccga caccgcaatc     1320
aacaaggtca cggtcatcgg cggcaacaat gcggatatca acgctcccta tggttatctg     1380
aaggtccccg gtgacctcaa cagaggtgct ggcggcaact tcatctatgc ctgtaccttc     1440
gtaggcaag                                                             1449

<210>  242
<211>  1449
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  242
atggaaaaca tagacttgcc acaaggactt gtaaactttt ccacgcaaca cctgcaactt       60
attcgtttta aagcaggttt gaatgaaacc gtactacctg gcgtcgaagc cattggactt      120
ggctataacc cattcatcag ttatgccagt gtcaacagcg gcgcggtgca attgttcgac      180
tgggccacgg ccaagaaacg cgaagtgcct ttcaaagccg gctacttcgt acccgagctc      240
gtcgacgtgc aacagaacga cagcgcaacc ttcaccaacg tcagcggcaa cacgctcagc      300
gagtaccagc gcagtctggc taccagcgtc gccatcgaag gccgttacaa cttcttcagt      360
ggctcgctgt ccacggattt cgacagtaat tcactgcgca acgcggaaaa cgagttcact      420
cgcattcagc aatcgatcaa cctctggtcg ttgcgcttgc cttcggtgaa gtcattgcgc      480
gaactgatgc tgccacacat gcgccaacaa ctagatgaat tgaacgtcaa cgacccgaag      540
gccataagcc gctatttcga tagagttggc agccatttcc ttaccggcat cgtaatgggt      600
ggacgggcca tcctcgcctc ctcgaccaac aagctcaggg tcaagcgtga ctactcggtg      660
tcggtggtcg ccaaggcgag ctacgaaggg cttaccggcc agttgagcgc agaagccaaa      720
gccaagtatg gcgagtcgat cagcagcttc actcagtact ccaataccca ccaggaagtg      780
cgcggcggcg acggtgccaa ggcacatggg gtgttcagcg gcaaaaaaga agatttccag      840
gcctgggtag acagtgtgag cgcctcgccg gacttcgtcg atttcgtccc caccatcccc      900
atgcaggaaa tctggaccct gtgcagcagc gaggcgcagg ccgaggccat gcgcaagcat      960
tacgatgacg tctgggcgcc ggcgcaatcg gaaaagtacc gggtcaaggc taacttcatc     1020
gaccaactgg tggtcctcac cggcggtagt tcaaccctcg aaccaccggt cggctacagc     1080
aagatcgagt acgacctcaa tgccggtgcc ggcggtgact tcatctactt gtgctatcac     1140
gaacaaacct ggcaggccga caggcctaaa gatgctgtga cggatatcag gatcattttc     1200
aacaaggagc ctaccccacc tggctatacc aagctgcccc aggacctgaa caagggcgcg     1260
ggcggtgatg atgtattcct ctgctacaag accgaggctt tcaacaccga caccgcactc     1320
aacaaggtca cggtcatcgg cggcaacaat gcggatatca acgctccctt tggttatctg     1380
aaggtccccg gtgacctcaa cagaggtgct ggcggcaact tcatctatgc ctgtaccttc     1440
gtaggcaag                                                             1449

<210>  243
<211>  1176
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  243
atggaaaaca tagacttgcc acaaggactt gtaaactttt ccacgcaaca cctgcaactt       60
attcgtttta aagcaggttt gaatgaaacc gtactacctg gcgtcgaagc cattggactt      120
ggctataacc cattcatcag ttatgccagt gtcaacagcg gcgcggtgca attgttcgac      180
tgggccacgg ccaagaaacg cgaagtgcct ttcaaagccg gctacttcgt acccgagctc      240
gtcgacgtgc aacagaacga cagcgcaacc ttcaccaacg tcagcggcaa cacgatcagc      300
gagtaccagc gcagtctggc taccagcgtc gccatcgaag gccgttacaa cttcttcagt      360
ggctcgctgt ccacggattt cgacagtaat tcactgcgca acgcggaaaa cgagttcact      420
cgcattcagc aatcgatcaa cctctggtcg ttgcgcttgc cttcggtgaa gtcattgcgc      480
gaactgatgc tgccacacat gcgccaacaa ctagatgaat tgaacgtcaa cgacccgaag      540
gccataagcc gctatttcga tagagttggc agccatttcc ttaccggcat cgtaatgggt      600
ggacgggcca tcctcgcctc ctcgaccaac aagctcaggg tcaagcgtga ctactcggtg      660
tcggtggtcg ccaaggcgag ctacgaaggg cttaccggcc agttgagcgc agaagccaaa      720
gccaagtatg gcgagtcgat cagcagcttc actcagtact ccaataccca ccaggaagtg      780
cgcggcggcg acggtgccaa ggcacatggg gtgttcagcg gcaaaaaaga agatttccag      840
gcctgggtag acagtgtgag cgcctcgccg gacttcgtcg atttcgtccc caccatcccc      900
atgcaggaaa tctggaccct gtgcagcagc gaggcgcagg ccgaggccat gcgaagcatt      960
tcgatgacgt ctgggcgccg gcgcaatcgg aaaagttccg ggtcaaggct aactacctcg     1020
accaactggt ggtcatcacc ggcggtagtt caaccctcga accaccggtc ggctacagca     1080
agctcgagta cgacctcaat gccggtgccg gcggtgactt catctacttg tgctatcacg     1140
aacaaacctg gcaggccgac aggcctaaag atgctg                               1176

<210>  244
<211>  1449
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  244
atggaaaaca tagacttgcc acaaggactt gtaaactttt ccacgcaaca cctgcaactt       60
attcgtttta aagcaggttt gaatgaaacc gtactacctg gcgtcgaagc cattggactt      120
ggctataacc cattcatcag ttatgccagt gtcaacagcg gcgcggtgca attgttcgac      180
tgggccacgg ccaagaaacg cgaagtgcct ttcaaagccg gctacttcgt acccgagctc      240
gtcgacgtgc aacagaacga cagcgcaacc tacaccaacg tcagcggcaa cacgctcagc      300
gagtaccagc gcagtctggc taccagcgtc gccatcgaag gccgttacaa cttcttcagt      360
ggctcgctgt ccacggattt cgacagtaat tcactgcgca acgcggaaaa cgagttcact      420
cgcattcagc aatcgatcaa cctctggtcg ttgcgcttgc cttcggtgaa gtcattgcgc      480
gaactgatgc tgccacacat gcgccaacaa ctagatgaat tgaacgtcaa cgacccgaag      540
gccataagcc gctatttcga tagagttggc agccatttcc ttaccggcat cgtaatgggt      600
ggacgggcca tcctcgcctc ctcgaccaac aagctcaggg tcaagcgtga ctactcggtg      660
tcggtggtcg ccaaggcgag ctacgaaggg cttaccggcc agttgagcgc agaagccaaa      720
gccaagtatg gcgagtcgat cagcagcttc actcagtact ccaataccca ccaggaagtg      780
cgcggcggcg acggtgccaa ggcacatggg gtgttcagcg gcaaaaaaga agatttccag      840
gcctgggtag acagtgtgag cgcctcgccg gacttcgtcg atttcgtccc caccatcccc      900
atgcaggaaa tctggaccct gtgcagcagc gaggcgcagg ccgaggccat gcgcaagcat      960
tacgatgacg tctgggcgcc ggcgcaatcg gaaaagtacc gggtcaaggc taactacatc     1020
gaccaactgg tggtcctcac cggcggtagt tcaaccatcg aaccaccggt cggctacagc     1080
aagatcgagt acgacctcaa tgccggtgcc ggcggtgact tcatctactt gtgctatcac     1140
gaacaaacct ggcaggccga caggcctaaa gatgctgtga cggatatcag gatcattttc     1200
aacaaggagc ctaccccacc tggctatacc aagctgcccc aggacctgaa caagggcgcg     1260
ggcggtgatg atgtattcct ctgctacaag accgaggctt acaacaccga caccgcactc     1320
aacaaggtca cggtcatcgg cggcaacaat gcggatatca acgctcccta tggttatctg     1380
aaggtccccg gtgacctcaa cagaggtgct ggcggcaact tcatctatgc ctgtaccttc     1440
gtaggcaag                                                             1449

<210>  245
<211>  1449
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  245
atggaaaaca tagacttgcc acaaggactt gtaaactttt ccacgcaaca cctgcaactt       60
attcgtttta aagcaggttt gaatgaaacc gtactacctg gcgtcgaagc cattggactt      120
ggctataacc cattcatcag ttatgccagt gtcaacagcg gcgcggtgca attgttcgac      180
tgggccacgg ccaagaaacg cgaagtgcct ttcaaagccg gctacttcgt acccgagctc      240
gtcgacgtgc aacagaacga cagcgcaacc ttcaccaacg tcagcggcaa cacgatcagc      300
gagtaccagc gcagtctggc taccagcgtc gccatcgaag gccgttacaa cttcttcagt      360
ggctcgctgt ccacggattt cgacagtaat tcactgcgca acgcggaaaa cgagttcact      420
cgcattcagc aatcgatcaa cctctggtcg ttgcgcttgc cttcggtgaa gtcattgcgc      480
gaactgatgc tgccacacat gcgccaacaa ctagatgaat tgaacgtcaa cgacccgaag      540
gccataagcc gctatttcga tagagttggc agccatttcc ttaccggcat cgtaatgggt      600
ggacgggcca tcctcgcctc ctcgaccaac aagctcaggg tcaagcgtga ctactcggtg      660
tcggtggtcg ccaaggcgag ctacgaaggg cttaccggcc agttgagcgc agaagccaaa      720
gccaagtatg gcgagtcgat cagcagcttc actcagtact ccaataccca ccaggaagtg      780
cgcggcggcg acggtgccaa ggcacatggg gtgttcagcg gcaaaaaaga agatttccag      840
gcctgggtag acagtgtgag cgcctcgccg gacttcgtcg atttcgtccc caccatcccc      900
atgcaggaaa tctggaccct gtgcagcagc gaggcgcagg ccgaggccat gcgcaagcat      960
ttcgatgacg tctgggcgcc ggcgcaatcg gaaaagttcc gggtcaaggc taactacatc     1020
gaccaactgg tggtcatcac cggcggtagt tcaaccatcg aaccaccggt cggctacagc     1080
aagatcgagt acgacctcaa tgccggtgcc ggcggtgact tcatctactt gtgctatcac     1140
gaacaaacct ggcaggccga caggcctaaa gatgctgtga cggatatcag gatcattttc     1200
aacaaggagc ctaccccacc tggctatacc aagctgcccc aggacctgaa caagggcgcg     1260
ggcggtgatg atgtattcct ctgctacaag accgaggctt acaacaccga caccgcaatc     1320
aacaaggtca cggtcatcgg cggcaacaat gcggatatca acgctcccta tggttatctg     1380
aaggtccccg gtgacctcaa cagaggtgct ggcggcaact tcatctatgc ctgtaccttc     1440
gtaggcaag                                                             1449

<210>  246
<211>  1449
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  246
atggaaaaca tagacttgcc acaaggactt gtaaactttt ccacgcaaca cctgcaactt       60
attcgtttta aagcaggttt gaatgaaacc gtactacctg gcgtcgaagc cattggactt      120
ggctataacc cattcatcag ttatgccagt gtcaacagcg gcgcggtgca attgttcgac      180
tgggccacgg ccaagaaacg cgaagtgcct ttcaaagccg gctacttcgt acccgagctc      240
gtcgacgtgc aacagaacga cagcgcaacc tacaccaacg tcagcggcaa cacgctcagc      300
gagtaccagc gcagtctggc taccagcgtc gccatcgaag gccgttacaa cttcttcagt      360
ggctcgctgt ccacggattt cgacagtaat tcactgcgca acgcggaaaa cgagttcact      420
cgcattcagc aatcgatcaa cctctggtcg ttgcgcttgc cttcggtgaa gtcattgcgc      480
gaactgatgc tgccacacat gcgccaacaa ctagatgaat tgaacgtcaa cgacccgaag      540
gccataagcc gctatttcga tagagttggc agccatttcc ttaccggcat cgtaatgggt      600
ggacgggcca tcctcgcctc ctcgaccaac aagctcaggg tcaagcgtga ctactcggtg      660
tcggtggtcg ccaaggcgag ctacgaaggg cttaccggcc agttgagcgc agaagccaaa      720
gccaagtatg gcgagtcgat cagcagcttc actcagtact ccaataccca ccaggaagtg      780
cgcggcggcg acggtgccaa ggcacatggg gtgttcagcg gcaaaaaaga agatttccag      840
gcctgggtag acagtgtgag cgcctcgccg gacttcgtcg atttcgtccc caccatcccc      900
atgcaggaaa tctggaccct gtgcagcagc gaggcgcagg ccgaggccat gcgcaagcat      960
tacgatgacg tctgggcgcc ggcgcaatcg gaaaagttcc gggtcaaggc taactacatc     1020
gaccaactgg tggtcatcac cggcggtagt tcaaccatcg aaccaccggt cggctacagc     1080
aagctcgagt acgacctcaa tgccggtgcc ggcggtgact tcatctactt gtgctatcac     1140
gaacaaacct ggcaggccga caggcctaaa gatgctgtga cggatatcag gatcattttc     1200
aacaaggagc ctaccccacc tggctatacc aagctgcccc aggacctgaa caagggcgcg     1260
ggcggtgatg atgtattcct ctgctacaag accgaggctt acaacaccga caccgcaatc     1320
aacaaggtca cggtcatcgg cggcaacaat gcggatctca acgctcccta tggttatctg     1380
aaggtccccg gtgacctcaa cagaggtgct ggcggcaact tcatctatgc ctgtaccttc     1440
gtaggcaag                                                             1449

<210>  247
<211>  1449
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  247
atggaaaaca tagacttgcc acaaggactt gtaaactttt ccacgcaaca cctgcaactt       60
attcgtttta aagcaggttt gaatgaaacc gtactacctg gcgtcgaagc cattggactt      120
ggctataacc cattcatcag ttatgccagt gtcaacagcg gcgcggtgca attgttcgac      180
tgggccacgg ccaagaaacg cgaagtgcct ttcaaagccg gctacttcgt acccgagatc      240
gtcgacgtgc aacagaacga cagcgcaacc ttcaccaacg tcagcggcaa cacgatcagc      300
gagtaccagc gcagtctggc taccagcgtc gccatcgaag gccgttacaa cttcttcagt      360
ggctcgctgt ccacggattt cgacagtaat tcactgcgca acgcggaaaa cgagttcact      420
cgcattcagc aatcgatcaa cctctggtcg ttgcgcttgc cttcggtgaa gtcattgcgc      480
gaactgatgc tgccacacat gcgccaacaa ctagatgaat tgaacgtcaa cgacccgaag      540
gccataagcc gctatttcga tagagttggc agccatttcc ttaccggcat cgtaatgggt      600
ggacgggcca tcctcgcctc ctcgaccaac aagctcaggg tcaagcgtga ctactcggtg      660
tcggtggtcg ccaaggcgag ctacgaaggg cttaccggcc agttgagcgc agaagccaaa      720
gccaagtatg gcgagtcgat cagcagcttc actcagtact ccaataccca ccaggaagtg      780
cgcggcggcg acggtgccaa ggcacatggg gtgttcagcg gcaaaaaaga agatttccag      840
gcctgggtag acagtgtgag cgcctcgccg gacttcgtcg atttcgtccc caccatcccc      900
atgcaggaaa tctggaccct gtgcagcagc gaggcgcagg ccgaggccat gcgcaagcat      960
tacgatgacg tctgggcgcc ggcgcaatcg gaaaagttcc gggtcaaggc taactacatc     1020
gaccaactgg tggtcatcac cggcggtagt tcaaccatcg aaccaccggt cggctacagc     1080
aagatcgagt acgacctcaa tgccggtgcc ggcggtgact tcatctactt gtgctatcac     1140
gaacaaacct ggcaggccga caggcctaaa gatgctgtga cggatatcag gatcattttc     1200
aacaaggagc ctaccccacc tggctatacc aagctgcccc aggacctgaa caagggcgcg     1260
ggcggtgatg atgtattcct ctgctacaag accgaggctt acaacaccga caccgcactc     1320
aacaaggtca cggtcatcgg cggcaacaat gcggatatca acgctccctt tggttatctg     1380
aaggtccccg gtgacctcaa cagaggtgct ggcggcaact tcatctatgc ctgtaccttc     1440
gtaggcaag                                                             1449

<210>  248
<211>  1449
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  248
atggaaaaca tagacttgcc acaaggactt gtaaactttt ccacgcaaca cctgcaactt       60
attcgtttta aagcaggttt gaatgaaacc gtactacctg gcgtcgaagc cattggactt      120
ggctataacc cattcatcag ttatgccagt gtcaacagcg gcgcggtgca attgttcgac      180
tgggccacgg ccaagaaacg cgaagtgcct ttcaaagccg gctacttcgt acccgagctc      240
gtcgacgtgc aacagaacga cagcgcaacc ttcaccaacg tcagcggcaa cacgctcagc      300
gagtaccagc gcagtctggc taccagcgtc gccatcgaag gccgttacaa cttcttcagt      360
ggctcgctgt ccacggattt cgacagtaat tcactgcgca acgcggaaaa cgagttcact      420
cgcattcagc aatcgatcaa cctctggtcg ttgcgcttgc cttcggtgaa gtcattgcgc      480
gaactgatgc tgccacacat gcgccaacaa ctagatgaat tgaacgtcaa cgacccgaag      540
gccataagcc gctatttcga tagagttggc agccatttcc ttaccggcat cgtaatgggt      600
ggacgggcca tcctcgcctc ctcgaccaac aagctcaggg tcaagcgtga ctactcggtg      660
tcggtggtcg ccaaggcgag ctacgaaggg cttaccggcc agttgagcgc agaagccaaa      720
gccaagtatg gcgagtcgat cagcagcttc actcagtact ccaataccca ccaggaagtg      780
cgcggcggcg acggtgccaa ggcacatggg gtgttcagcg gcaaaaaaga agatttccag      840
gcctgggtag acagtgtgag cgcctcgccg gacttcgtcg atttcgtccc caccatcccc      900
atgcaggaaa tctggaccct gtgcagcagc gaggcgcagg ccgaggccat gcgcaagcat      960
tacgatgacg tctgggcgcc ggcgcaatcg gaaaagtacc gggtcaaggc taactacatc     1020
gaccaactgg tggtcctcac cggcggtagt tcaaccatcg aaccaccggt cggctacagc     1080
aagctcgagt acgacctcaa tgccggtgcc ggcggtgact tcatctactt gtgctatcac     1140
gaacaaacct ggcaggccga caggcctaaa gatgctgtga cggatatcag gatcattttc     1200
aacaaggagc ctaccccacc tggctatacc aagctgcccc aggacctgaa caagggcgcg     1260
ggcggtgatg atgtattcct ctgctacaag accgaggctt tcaacaccga caccgcactc     1320
aacaaggtca cggtcatcgg cggcaacaat gcggatatca acgctcccta tggttatctg     1380
aaggtccccg gtgacctcaa cagaggtgct ggcggcaact tcatctatgc ctgtaccttc     1440
gtaggcaag                                                             1449

<210>  249
<211>  1449
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  249
atggaaaaca tagacttgcc acaaggactt gtaaactttt ccacgcaaca cctgcaactt       60
attcgtttta aagcaggttt gaatgaaacc gtactacctg gcgtcgaagc cattggactt      120
ggctataacc cattcatcag ttatgccagt gtcaacagcg gcgcggtgca attgttcgac      180
tgggccacgg ccaagaaacg cgaagtgcct ttcaaagccg gctacttcgt acccgagctc      240
gtcgacgtgc aacagaacga cagcgcaacc ttcaccaacg tcagcggcaa cacgctcagc      300
gagtaccagc gcagtctggc taccagcgtc gccatcgaag gccgttacaa cttcttcagt      360
ggctcgctgt ccacggattt cgacagtaat tcactgcgca acgcggaaaa cgagttcact      420
cgcattcagc aatcgatcaa cctctggtcg ttgcgcttgc cttcggtgaa gtcattgcgc      480
gaactgatgc tgccacacat gcgccaacaa ctagatgaat tgaacgtcaa cgacccgaag      540
gccataagcc gctatttcga tagagttggc agccatttcc ttaccggcat cgtaatgggt      600
ggacgggcca tcctcgcctc ctcgaccaac aagctcaggg tcaagcgtga ctactcggtg      660
tcggtggtcg ccaaggcgag ctacgaaggg cttaccggcc agttgagcgc agaagccaaa      720
gccaagtatg gcgagtcgat cagcagcttc actcagtact ccaataccca ccaggaagtg      780
cgcggcggcg acggtgccaa ggcacatggg gtgttcagcg gcaaaaaaga agatttccag      840
gcctgggtag acagtgtgag cgcctcgccg gacttcgtcg atttcgtccc caccatcccc      900
atgcaggaaa tctggaccct gtgcagcagc gaggcgcagg ccgaggccat gcgcaagcat      960
ttcgatgacg tctgggcgcc ggcgcaatcg gaaaagtacc gggtcaaggc taactacatc     1020
gaccaactgg tggtcctcac cggcggtagt tcaaccatcg aaccaccggt cggctacagc     1080
aagatcgagt acgacctcaa tgccggtgcc ggcggtgact tcatctactt gtgctatcac     1140
gaacaaacct ggcaggccga caggcctaaa gatgctgtga cggatatcag gatcattttc     1200
aacaaggagc ctaccccacc tggctatacc aagctgcccc aggacctgaa caagggcgcg     1260
ggcggtgatg atgtattcct ctgctacaag accgaggctt tcaacaccga caccgcaatc     1320
aacaaggtca cggtcatcgg cggcaacaat gcggatatca acgctccctt tggttatctg     1380
aaggtccccg gtgacctcaa cagaggtgct ggcggcaact tcatctatgc ctgtaccttc     1440
gtaggcaag                                                             1449

<210>  250
<211>  1176
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  250
atggaaaaca tagacttgcc acaaggactt gtaaactttt ccacgcaaca cctgcaactt       60
attcgtttta aagcaggttt gaatgaaacc gtactacctg gcgtcgaagc cattggactt      120
ggctataacc cattcatcag ttatgccagt gtcaacagcg gcgcggtgca attgttcgac      180
tgggccacgg ccaagaaacg cgaagtgcct ttcaaagccg gctacttcgt acccgagctc      240
gtcgacgtgc aacagaacga cagcgcaacc ttcaccaacg tcagcggcaa cacgctcagc      300
gagtaccagc gcagtctggc taccagcgtc gccatcgaag gccgttacaa cttcttcagt      360
ggctcgctgt ccacggattt cgacagtaat tcactgcgca acgcggaaaa cgagttcact      420
cgcattcagc aatcgatcaa cctctggtcg ttgcgcttgc cttcggtgaa gtcattgcgc      480
gaactgatgc tgccacacat gcgccaacaa ctagatgaat tgaacgtcaa cgacccgaag      540
gccataagcc gctatttcga tagagttggc agccatttcc ttaccggcat cgtaatgggt      600
ggacgggcca tcctcgcctc ctcgaccaac aagctcaggg tcaagcgtga ctactcggtg      660
tcggtggtcg ccaaggcgag ctacgaaggg cttaccggcc agttgagcgc agaagccaaa      720
gccaagtatg gcgagtcgat cagcagcttc actcagtact ccaataccca ccaggaagtg      780
cgcggcggcg acggtgccaa ggcacatggg gtgttcagcg gcaaaaaaga agatttccag      840
gcctgggtag acagtgtgag cgcctcgccg gacttcgtcg atttcgtccc caccatcccc      900
atgcaggaaa tctggaccct gtgcagcagc gaggcgcagg ccgagccatg cgcaagcatt      960
tcgatgacgt ctgggcgccg gcgcaatcgg aaaagttccg ggtcaaggct aactacatcg     1020
accaactggt ggtcatcacc ggcggtagtt caaccctcga accaccggtc ggctacagca     1080
agatcgagta cgacctcaat gccggtgccg gcggtgactt catctacttg tgctatcacg     1140
aacaaacctg gcaggccgac aggcctaaag atgctg                               1176

<210>  251
<211>  1449
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  251
atggaaaaca tagacttgcc acaaggactt gtaaactttt ccacgcaaca cctgcaactt       60
attcgtttta aagcaggttt gaatgaaacc gtactacctg gcgtcgaagc cattggactt      120
ggctataacc cattcatcag ttatgccagt gtcaacagcg gcgcggtgca attgttcgac      180
tgggccacgg ccaagaaacg cgaagtgcct ttcaaagccg gctacttcgt acccgagctc      240
gtcgacgtgc aacagaacga cagcgcaacc ttcaccaacg tcagcggcaa cacgatcagc      300
gagtaccagc gcagtctggc taccagcgtc gccatcgaag gccgttacaa cttcttcagt      360
ggctcgctgt ccacggattt cgacagtaat tcactgcgca acgcggaaaa cgagttcact      420
cgcattcagc aatcgatcaa cctctggtcg ttgcgcttgc cttcggtgaa gtcattgcgc      480
gaactgatgc tgccacacat gcgccaacaa ctagatgaat tgaacgtcaa cgacccgaag      540
gccataagcc gctatttcga tagagttggc agccatttcc ttaccggcat cgtaatgggt      600
ggacgggcca tcctcgcctc ctcgaccaac aagctcaggg tcaagcgtga ctactcggtg      660
tcggtggtcg ccaaggcgag ctacgaaggg cttaccggcc agttgagcgc agaagccaaa      720
gccaagtatg gcgagtcgat cagcagcttc actcagtact ccaataccca ccaggaagtg      780
cgcggcggcg acggtgccaa ggcacatggg gtgttcagcg gcaaaaaaga agatttccag      840
gcctgggtag acagtgtgag cgcctcgccg gacttcgtcg atttcgtccc caccatcccc      900
atgcaggaaa tctggaccct gtgcagcagc gaggcgcagg ccgaggccat gcgcaagcat      960
ttcgatgacg tctgggcgcc ggcgcaatcg gaaaagtacc gggtcaaggc taactacctc     1020
gaccaactgg tggtcatcac cggcggtagt tcaaccatcg aaccaccggt cggctacagc     1080
aagatcgagt acgacctcaa tgccggtgcc ggcggtgact tcatctactt gtgctatcac     1140
gaacaaacct ggcaggccga caggcctaaa gatgctgtga cggatatcag gatcattttc     1200
aacaaggagc ctaccccacc tggctatacc aagctgcccc aggacctgaa caagggcgcg     1260
ggcggtgatg atgtattcct ctgctacaag accgaggctt tcaacaccga caccgcactc     1320
aacaaggtca cggtcatcgg cggcaacaat gcggatatca acgctcccta tggttatctg     1380
aaggtccccg gtgacctcaa cagaggtgct ggcggcaact tcatctatgc ctgtaccttc     1440
gtaggcaag                                                             1449

<210>  252
<211>  1449
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  252
atggaaaaca tagacttgcc acaaggactt gtaaactttt ccacgcaaca cctgcaactt       60
attcgtttta aagcaggttt gaatgaaacc gtactacctg gcgtcgaagc cattggactt      120
ggctataacc cattcatcag ttatgccagt gtcaacagcg gcgcggtgca attgttcgac      180
tgggccacgg ccaagaaacg cgaagtgcct ttcaaagccg gctacttcgt acccgagctc      240
gtcgacgtgc aacagaacga cagcgcaacc ttcaccaacg tcagcggcaa cacgatcagc      300
gagtaccagc gcagtctggc taccagcgtc gccatcgaag gccgttacaa cttcttcagt      360
ggctcgctgt ccacggattt cgacagtaat tcactgcgca acgcggaaaa cgagttcact      420
cgcattcagc aatcgatcaa cctctggtcg ttgcgcttgc cttcggtgaa gtcattgcgc      480
gaactgatgc tgccacacat gcgccaacaa ctagatgaat tgaacgtcaa cgacccgaag      540
gccataagcc gctatttcga tagagttggc agccatttcc ttaccggcat cgtaatgggt      600
ggacgggcca tcctcgcctc ctcgaccaac aagctcaggg tcaagcgtga ctactcggtg      660
tcggtggtcg ccaaggcgag ctacgaaggg cttaccggcc agttgagcgc agaagccaaa      720
gccaagtatg gcgagtcgat cagcagcttc actcagtact ccaataccca ccaggaagtg      780
cgcggcggcg acggtgccaa ggcacatggg gtgttcagcg gcaaaaaaga agatttccag      840
gcctgggtag acagtgtgag cgcctcgccg gacttcgtcg atttcgtccc caccatcccc      900
atgcaggaaa tctggaccct gtgcagcagc gaggcgcagg ccgaggccat gcgcaagcat      960
tacgatgacg tctgggcgcc ggcgcaatcg gaaaagttcc gggtcaaggc taactacatc     1020
gaccaactgg tggtcatcac cggcggtagt tcaaccatcg aaccaccggt cggctacagc     1080
aagatcgagt acgacctcaa tgccggtgcc ggcggtgact tcatctactt gtgctatcac     1140
gaacaaacct ggcaggccga caggcctaaa gatgctgtga cggatatcag gatcattttc     1200
aacaaggagc ctaccccacc tggctatacc aagctgcccc aggacctgaa caagggcgcg     1260
ggcggtgatg atgtattcct ctgctacaag accgaggctt acaacaccga caccgcaatc     1320
aacaaggtca cggtcctcgg cggcaacaat gcggatatca acgctcccta tggttatctg     1380
aaggtccccg gtgacctcaa cagaggtgct ggcggcaact tcatctatgc ctgtaccttc     1440
gtaggcaag                                                             1449

<210>  253
<211>  1449
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  253
atggaaaaca tagacttgcc acaaggactt gtaaactttt ccacgcaaca cctgcaactt       60
attcgtttta aagcaggttt gaatgaaacc gtactacctg gcgtcgaagc cattggactt      120
ggctataacc cattcatcag ttatgccagt gtcaacagcg gcgcggtgca attgttcgac      180
tgggccacgg ccaagaaacg cgaagtgcct ttcaaagccg gctacttcgt acccgagctc      240
gtcgacgtgc aacagaacga cagcgcaacc ttcaccaacg tcagcggcaa cacgatcagc      300
gagtaccagc gcagtctggc taccagcgtc gccatcgaag gccgttacaa cttcttcagt      360
ggctcgctgt ccacggattt cgacagtaat tcactgcgca acgcggaaaa cgagttcact      420
cgcattcagc aatcgatcaa cctctggtcg ttgcgcttgc cttcggtgaa gtcattgcgc      480
gaactgatgc tgccacacat gcgccaacaa ctagatgaat tgaacgtcaa cgacccgaag      540
gccataagcc gctatttcga tagagttggc agccatttcc ttaccggcat cgtaatgggt      600
ggacgggcca tcctcgcctc ctcgaccaac aagctcaggg tcaagcgtga ctactcggtg      660
tcggtggtcg ccaaggcgag ctacgaaggg cttaccggcc agttgagcgc agaagccaaa      720
gccaagtatg gcgagtcgat cagcagcttc actcagtact ccaataccca ccaggaagtg      780
cgcggcggcg acggtgccaa ggcacatggg gtgttcagcg gcaaaaaaga agatttccag      840
gcctgggtag acagtgtgag cgcctcgccg gacttcgtcg atttcgtccc caccatcccc      900
atgcaggaaa tctggaccct gtgcagcagc gaggcgcagg ccgaggccat gcgcaagcat      960
tacgatgacg tctgggcgcc ggcgcaatcg gaaaagttcc gggtcaaggc taactacatc     1020
gaccaactgg tggtcatcac cggcggtagt tcaaccatcg aaccaccggt cggctacagc     1080
aagatcgagt acgacctcaa tgccggtgcc ggcggtgact tcatctactt gtgctatcac     1140
gaacaaacct ggcaggccga caggcctaaa gatgctgtga cggatatcag gatcattttc     1200
aacaaggagc ctaccccacc tggctatacc aagctgcccc aggacctgaa caagggcgcg     1260
ggcggtgatg atgtattcct ctgctacaag accgaggctt acaacaccga caccgcaatc     1320
aacaaggtca cggtcatcgg cggcaacaat gcggatatca acgctccctt tggttatctg     1380
aaggtccccg gtgacctcaa cagaggtgct ggcggcaact tcatctatgc ctgtaccttc     1440
gtaggcaag                                                             1449

<210>  254
<211>  1449
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  254
atggaaaaca tagacttgcc acaaggactt gtaaactttt ccacgcaaca cctgcaactt       60
attcgtttta aagcaggttt gaatgaaacc gtactacctg gcgtcgaagc cattggactt      120
ggctataacc cattcatcag ttatgccagt gtcaacagcg gcgcggtgca attgttcgac      180
tgggccacgg ccaagaaacg cgaagtgcct ttcaaagccg gctacttcgt acccgagctc      240
gtcgacgtgc aacagaacga cagcgcaacc tacaccaacg tcagcggcaa cacgatcagc      300
gagtaccagc gcagtctggc taccagcgtc gccatcgaag gccgttacaa cttcttcagt      360
ggctcgctgt ccacggattt cgacagtaat tcactgcgca acgcggaaaa cgagttcact      420
cgcattcagc aatcgatcaa cctctggtcg ttgcgcttgc cttcggtgaa gtcattgcgc      480
gaactgatgc tgccacacat gcgccaacaa ctagatgaat tgaacgtcaa cgacccgaag      540
gccataagcc gctatttcga tagagttggc agccatttcc ttaccggcat cgtaatgggt      600
ggacgggcca tcctcgcctc ctcgaccaac aagctcaggg tcaagcgtga ctactcggtg      660
tcggtggtcg ccaaggcgag ctacgaaggg cttaccggcc agttgagcgc agaagccaaa      720
gccaagtatg gcgagtcgat cagcagcttc actcagtact ccaataccca ccaggaagtg      780
cgcggcggcg acggtgccaa ggcacatggg gtgttcagcg gcaaaaaaga agatttccag      840
gcctgggtag acagtgtgag cgcctcgccg gacttcgtcg atttcgtccc caccatcccc      900
atgcaggaaa tctggaccct gtgcagcagc gaggcgcagg ccgaggccat gcgcaagcat      960
tacgatgacg tctgggcgcc ggcgcaatcg gaaaagtacc gggtcaaggc taactacctc     1020
gaccaactgg tggtcatcac cggcggtagt tcaaccatcg aaccaccggt cggctacagc     1080
aagatcgagt acgacctcaa tgccggtgcc ggcggtgact tcatctactt gtgctatcac     1140
gaacaaacct ggcaggccga caggcctaaa gatgctgtga cggatatcag gatcattttc     1200
aacaaggagc ctaccccacc tggctatacc aagctgcccc aggacctgaa caagggcgcg     1260
ggcggtgatg atgtattcct ctgctacaag accgaggctt acaacaccga caccgcactc     1320
aacaaggtca cggtcatcgg cggcaacaat gcggatatca acgctccctt tggttatctg     1380
aaggtccccg gtgacctcaa cagaggtgct ggcggcaact tcatctatgc ctgtaccttc     1440
gtaggcaag                                                             1449

<210>  255
<211>  1449
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  255
atggaaaaca tagacttgcc acaaggactt gtaaactttt ccacgcaaca cctgcaactt       60
attcgtttta aagcaggttt gaatgaaacc gtactacctg gcgtcgaagc cattggactt      120
ggctataacc cattcatcag ttatgccagt gtcaacagcg gcgcggtgca attgttcgac      180
tgggccacgg ccaagaaacg cgaagtgcct ttcaaagccg gctacttcgt acccgagctc      240
gtcgacgtgc aacagaacga cagcgcaacc ttcaccaacg tcagcggcaa cacgatcagc      300
gagtaccagc gcagtctggc taccagcgtc gccatcgaag gccgttacaa cttcttcagt      360
ggctcgctgt ccacggattt cgacagtaat tcactgcgca acgcggaaaa cgagttcact      420
cgcattcagc aatcgatcaa cctctggtcg ttgcgcttgc cttcggtgaa gtcattgcgc      480
gaactgatgc tgccacacat gcgccaacaa ctagatgaat tgaacgtcaa cgacccgaag      540
gccataagcc gctatttcga tagagttggc agccatttcc ttaccggcat cgtaatgggt      600
ggacgggcca tcctcgcctc ctcgaccaac aagctcaggg tcaagcgtga ctactcggtg      660
tcggtggtcg ccaaggcgag ctacgaaggg cttaccggcc agttgagcgc agaagccaaa      720
gccaagtatg gcgagtcgat cagcagcttc actcagtact ccaataccca ccaggaagtg      780
cgcggcggcg acggtgccaa ggcacatggg gtgttcagcg gcaaaaaaga agatttccag      840
gcctgggtag acagtgtgag cgcctcgccg gacttcgtcg atttcgtccc caccatcccc      900
atgcaggaaa tctggaccct gtgcagcagc gaggcgcagg ccgaggccat gcgcaagcat      960
tacgatgacg tctgggcgcc ggcgcaatcg gaaaagttcc gggtcaaggc taactacatc     1020
gaccaactgg tggtcatcac cggcggtagt tcaaccatcg aaccaccggt cggctacagc     1080
aagatcgagt acgacctcaa tgccggtgcc ggcggtgact tcatctactt gtgctatcac     1140
gaacaaacct ggcaggccga caggcctaaa gatgctgtga cggatatcag gatcattttc     1200
aacaaggagc ctaccccacc tggctatacc aagctgcccc aggacctgaa caagggcgcg     1260
ggcggtgatg atgtattcct ctgctacaag accgaggctt acaacaccga caccgcaatc     1320
aacaaggtca cggtcatcgg cggcaacaat gcggatatca acgctcccta tggttatctg     1380
aaggtccccg gtgacctcaa cagaggtgct ggcggcaact tcatctatgc ctgtaccttc     1440
gtaggcaag                                                             1449

<210>  256
<211>  1449
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  256
atggaaaaca tagacttgcc acaaggactt gtaaactttt ccacgcaaca cctgcaactt       60
attcgtttta aagcaggttt gaatgaaacc gtactacctg gcgtcgaagc cattggactt      120
ggctataacc cattcatcag ttatgccagt gtcaacagcg gcgcggtgca attgttcgac      180
tgggccacgg ccaagaaacg cgaagtgcct ttcaaagccg gctacttcgt acccgagatc      240
gtcgacgtgc aacagaacga cagcgcaacc ttcaccaacg tcagcggcaa cacgatcagc      300
gagtaccagc gcagtctggc taccagcgtc gccatcgaag gccgttacaa cttcttcagt      360
ggctcgctgt ccacggattt cgacagtaat tcactgcgca acgcggaaaa cgagttcact      420
cgcattcagc aatcgatcaa cctctggtcg ttgcgcttgc cttcggtgaa gtcattgcgc      480
gaactgatgc tgccacacat gcgccaacaa ctagatgaat tgaacgtcaa cgacccgaag      540
gccataagcc gctatttcga tagagttggc agccatttcc ttaccggcat cgtaatgggt      600
ggacgggcca tcctcgcctc ctcgaccaac aagctcaggg tcaagcgtga ctactcggtg      660
tcggtggtcg ccaaggcgag ctacgaaggg cttaccggcc agttgagcgc agaagccaaa      720
gccaagtatg gcgagtcgat cagcagcttc actcagtact ccaataccca ccaggaagtg      780
cgcggcggcg acggtgccaa ggcacatggg gtgttcagcg gcaaaaaaga agatttccag      840
gcctgggtag acagtgtgag cgcctcgccg gacttcgtcg atttcgtccc caccatcccc      900
atgcaggaaa tctggaccct gtgcagcagc gaggcgcagg ccgaggccat gcgcaagcat      960
tacgatgacg tctgggcgcc ggcgcaatcg gaaaagttcc gggtcaaggc taactacatc     1020
gaccaactgg tggtcatcac cggcggtagt tcaaccatcg aaccaccggt cggctacagc     1080
aagatcgagt acgacctcaa tgccggtgcc ggcggtgact tcatctactt gtgctatcac     1140
gaacaaacct ggcaggccga caggcctaaa gatgctgtga cggatatcag gatcattttc     1200
aacaaggagc ctaccccacc tggctatacc aagctgcccc aggacctgaa caagggcgcg     1260
ggcggtgatg atgtattcct ctgctacaag accgaggctt acaacaccga caccgcaatc     1320
aacaaggtca cggtcatcgg cggcaacaat gcggatatca acgctcccta tggttatctg     1380
aaggtccccg gtgacctcaa cagaggtgct ggcggcaact tcatctatgc ctgtaccttc     1440
gtaggcaag                                                             1449

<210>  257
<211>  1449
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  257
atggaaaaca tagacttgcc acaaggactt gtaaactttt ccacgcaaca cctgcaactt       60
attcgtttta aagcaggttt gaatgaaacc gtactacctg gcgtcgaagc cattggactt      120
ggctataacc cattcatcag ttatgccagt gtcaacagcg gcgcggtgca attgttcgac      180
tgggccacgg ccaagaaacg cgaagtgcct ttcaaagccg gctacttcgt acccgagctc      240
gtcgacgtgc aacagaacga cagcgcaacc tacaccaacg tcagcggcaa cacgatcagc      300
gagtaccagc gcagtctggc taccagcgtc gccatcgaag gccgttacaa cttcttcagt      360
ggctcgctgt ccacggattt cgacagtaat tcactgcgca acgcggaaaa cgagttcact      420
cgcattcagc aatcgatcaa cctctggtcg ttgcgcttgc cttcggtgaa gtcattgcgc      480
gaactgatgc tgccacacat gcgccaacaa ctagatgaat tgaacgtcaa cgacccgaag      540
gccataagcc gctatttcga tagagttggc agccatttcc ttaccggcat cgtaatgggt      600
ggacgggcca tcctcgcctc ctcgaccaac aagctcaggg tcaagcgtga ctactcggtg      660
tcggtggtcg ccaaggcgag ctacgaaggg cttaccggcc agttgagcgc agaagccaaa      720
gccaagtatg gcgagtcgat cagcagcttc actcagtact ccaataccca ccaggaagtg      780
cgcggcggcg acggtgccaa ggcacatggg gtgttcagcg gcaaaaaaga agatttccag      840
gcctgggtag acagtgtgag cgcctcgccg gacttcgtcg atttcgtccc caccatcccc      900
atgcaggaaa tctggaccct gtgcagcagc gaggcgcagg ccgaggccat gcgcaagcat      960
ttcgatgacg tctgggcgcc ggcgcaatcg gaaaagttcc gggtcaaggc taactacatc     1020
gaccaactgg tggtcatcac cggcggtagt tcaaccatcg aaccaccggt cggctacagc     1080
aagatcgagt acgacctcaa tgccggtgcc ggcggtgact tcatctactt gtgctatcac     1140
gaacaaacct ggcaggccga caggcctaaa gatgctgtga cggatatcag gatcattttc     1200
aacaaggagc ctaccccacc tggctatacc aagctgcccc aggacctgaa caagggcgcg     1260
ggcggtgatg atgtattcct ctgctacaag accgaggctt acaacaccga caccgcactc     1320
aacaaggtca cggtcatcgg cggcaacaat gcggatatca acgctccctt tggttatctg     1380
aaggtccccg gtgacctcaa cagaggtgct ggcggcaact tcatctatgc ctgtaccttc     1440
gtaggcaag                                                             1449

<210>  258
<211>  1449
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  258
atggaaaaca tagacttgcc acaaggactt gtaaactttt ccacgcaaca cctgcaactt       60
attcgtttta aagcaggttt gaatgaaacc gtactacctg gcgtcgaagc cattggactt      120
ggctataacc cattcatcag ttatgccagt gtcaacagcg gcgcggtgca attgttcgac      180
tgggccacgg ccaagaaacg cgaagtgcct ttcaaagccg gctacttcgt acccgagctc      240
gtcgacgtgc aacagaacga cagcgcaacc tacaccaacg tcagcggcaa cacgatcagc      300
gagtaccagc gcagtctggc taccagcgtc gccatcgaag gccgttacaa cttcttcagt      360
ggctcgctgt ccacggattt cgacagtaat tcactgcgca acgcggaaaa cgagttcact      420
cgcattcagc aatcgatcaa cctctggtcg ttgcgcttgc cttcggtgaa gtcattgcgc      480
gaactgatgc tgccacacat gcgccaacaa ctagatgaat tgaacgtcaa cgacccgaag      540
gccataagcc gctatttcga tagagttggc agccatttcc ttaccggcat cgtaatgggt      600
ggacgggcca tcctcgcctc ctcgaccaac aagctcaggg tcaagcgtga ctactcggtg      660
tcggtggtcg ccaaggcgag ctacgaaggg cttaccggcc agttgagcgc agaagccaaa      720
gccaagtatg gcgagtcgat cagcagcttc actcagtact ccaataccca ccaggaagtg      780
cgcggcggcg acggtgccaa ggcacatggg gtgttcagcg gcaaaaaaga agatttccag      840
gcctgggtag acagtgtgag cgcctcgccg gacttcgtcg atttcgtccc caccatcccc      900
atgcaggaaa tctggaccct gtgcagcagc gaggcgcagg ccgaggccat gcgcaagcat      960
tacgatgacg tctgggcgcc ggcgcaatcg gaaaagttcc gggtcaaggc taactacatc     1020
gaccaactgg tggtcatcac cggcggtagt tcaaccatcg aaccaccggt cggctacagc     1080
aagatcgagt acgacctcaa tgccggtgcc ggcggtgact tcatctactt gtgctatcac     1140
gaacaaacct ggcaggccga caggcctaaa gatgctgtga cggatatcag gatcattttc     1200
aacaaggagc ctaccccacc tggctatacc aagctgcccc aggacctgaa caagggcgcg     1260
ggcggtgatg atgtattcct ctgctacaag accgaggctt acaacaccga caccgcaatc     1320
aacaaggtca cggtcctcgg cggcaacaat gcggatatca acgctcccta tggttatctg     1380
aaggtccccg gtgacctcaa cagaggtgct ggcggcaact tcatctatgc ctgtaccttc     1440
gtaggcaag                                                             1449

<210>  259
<211>  1449
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  259
atggaaaaca tagacttgcc acaaggactt gtaaactttt ccacgcaaca cctgcaactt       60
attcgtttta aagcaggttt gaatgaaacc gtactacctg gcgtcgaagc cattggactt      120
ggctataacc cattcatcag ttatgccagt gtcaacagcg gcgcggtgca attgttcgac      180
tgggccacgg ccaagaaacg cgaagtgcct ttcaaagccg gctacttcgt acccgagctc      240
gtcgacgtgc aacagaacga cagcgcaacc ttcaccaacg tcagcggcaa cacgatcagc      300
gagtaccagc gcagtctggc taccagcgtc gccatcgaag gccgttacaa cttcttcagt      360
ggctcgctgt ccacggattt cgacagtaat tcactgcgca acgcggaaaa cgagttcact      420
cgcattcagc aatcgatcaa cctctggtcg ttgcgcttgc cttcggtgaa gtcattgcgc      480
gaactgatgc tgccacacat gcgccaacaa ctagatgaat tgaacgtcaa cgacccgaag      540
gccataagcc gctatttcga tagagttggc agccatttcc ttaccggcat cgtaatgggt      600
ggacgggcca tcctcgcctc ctcgaccaac aagctcaggg tcaagcgtga ctactcggtg      660
tcggtggtcg ccaaggcgag ctacgaaggg cttaccggcc agttgagcgc agaagccaaa      720
gccaagtatg gcgagtcgat cagcagcttc actcagtact ccaataccca ccaggaagtg      780
cgcggcggcg acggtgccaa ggcacatggg gtgttcagcg gcaaaaaaga agatttccag      840
gcctgggtag acagtgtgag cgcctcgccg gacttcgtcg atttcgtccc caccatcccc      900
atgcaggaaa tctggaccct gtgcagcagc gaggcgcagg ccgaggccat gcgcaagcat      960
tacgatgacg tctgggcgcc ggcgcaatcg gaaaagttcc gggtcaaggc taactacatc     1020
gaccaactgg tggtcatcac cggcggtagt tcaaccatcg aaccaccggt cggctacagc     1080
aagatcgagt acgacctcaa tgccggtgcc ggcggtgact tcatctactt gtgctatcac     1140
gaacaaacct ggcaggccga caggcctaaa gatgctgtga cggatatcag gatcattttc     1200
aacaaggagc ctaccccacc tggctatacc aagctgcccc aggacctgaa caagggcgcg     1260
ggcggtgatg atgtattcct ctgctacaag accgaggctt acaacaccga caccgcaatc     1320
aacaaggtca cggtcctcgg cggcaacaat gcggatatca acgctcccta tggttatctg     1380
aaggtccccg gtgacctcaa cagaggtgct ggcggcaact tcatctatgc ctgtaccttc     1440
gtaggcaag                                                             1449

<210>  260
<211>  1449
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  260
atggaaaaca tagacttgcc acaaggactt gtaaactttt ccacgcaaca cctgcaactt       60
attcgtttta aagcaggttt gaatgaaacc gtactacctg gcgtcgaagc cattggactt      120
ggctataacc cattcatcag ttatgccagt gtcaacagcg gcgcggtgca attgttcgac      180
tgggccacgg ccaagaaacg cgaagtgcct ttcaaagccg gctacttcgt acccgagctc      240
gtcgacgtgc aacagaacga cagcgcaacc tacaccaacg tcagcggcaa cacgatcagc      300
gagtaccagc gcagtctggc taccagcgtc gccatcgaag gccgttacaa cttcttcagt      360
ggctcgctgt ccacggattt cgacagtaat tcactgcgca acgcggaaaa cgagttcact      420
cgcattcagc aatcgatcaa cctctggtcg ttgcgcttgc cttcggtgaa gtcattgcgc      480
gaactgatgc tgccacacat gcgccaacaa ctagatgaat tgaacgtcaa cgacccgaag      540
gccataagcc gctatttcga tagagttggc agccatttcc ttaccggcat cgtaatgggt      600
ggacgggcca tcctcgcctc ctcgaccaac aagctcaggg tcaagcgtga ctactcggtg      660
tcggtggtcg ccaaggcgag ctacgaaggg cttaccggcc agttgagcgc agaagccaaa      720
gccaagtatg gcgagtcgat cagcagcttc actcagtact ccaataccca ccaggaagtg      780
cgcggcggcg acggtgccaa ggcacatggg gtgttcagcg gcaaaaaaga agatttccag      840
gcctgggtag acagtgtgag cgcctcgccg gacttcgtcg atttcgtccc caccatcccc      900
atgcaggaaa tctggaccct gtgcagcagc gaggcgcagg ccgaggccat gcgcaagcat      960
tacgatgacg tctgggcgcc ggcgcaatcg gaaaagtacc gggtcaaggc taactacctc     1020
gaccaactgg tggtcatcac cggcggtagt tcaaccatcg aaccaccggt cggctacagc     1080
aagatcgagt acgacctcaa tgccggtgcc ggcggtgact tcatctactt gtgctatcac     1140
gaacaaacct ggcaggccga caggcctaaa gatgctgtga cggatatcag gatcattttc     1200
aacaaggagc ctaccccacc tggctatacc aagctgcccc aggacctgaa caagggcgcg     1260
ggcggtgatg atgtattcct ctgctacaag accgaggctt acaacaccga caccgcactc     1320
aacaaggtca cggtcatcgg cggcaacaat gcggatatca acgctcccta tggttatctg     1380
aaggtccccg gtgacctcaa cagaggtgct ggcggcaact tcatctatgc ctgtaccttc     1440
gtaggcaag                                                             1449

<210>  261
<211>  1449
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  261
atggaaaaca tagacttgcc acaaggactt gtaaactttt ccacgcaaca cctgcaactt       60
attcgtttta aagcaggttt gaatgaaacc gtactacctg gcgtcgaagc cattggactt      120
ggctataacc cattcatcag ttatgccagt gtcaacagcg gcgcggtgca attgttcgac      180
tgggccacgg ccaagaaacg cgaagtgcct ttcaaagccg gctacttcgt acccgagatc      240
gtcgacgtgc aacagaacga cagcgcaacc ttcaccaacg tcagcggcaa cacgatcagc      300
gagtaccagc gcagtctggc taccagcgtc gccatcgaag gccgttacaa cttcttcagt      360
ggctcgctgt ccacggattt cgacagtaat tcactgcgca acgcggaaaa cgagttcact      420
cgcattcagc aatcgatcaa cctctggtcg ttgcgcttgc cttcggtgaa gtcattgcgc      480
gaactgatgc tgccacacat gcgccaacaa ctagatgaat tgaacgtcaa cgacccgaag      540
gccataagcc gctatttcga tagagttggc agccatttcc ttaccggcat cgtaatgggt      600
ggacgggcca tcctcgcctc ctcgaccaac aagctcaggg tcaagcgtga ctactcggtg      660
tcggtggtcg ccaaggcgag ctacgaaggg cttaccggcc agttgagcgc agaagccaaa      720
gccaagtatg gcgagtcgat cagcagcttc actcagtact ccaataccca ccaggaagtg      780
cgcggcggcg acggtgccaa ggcacatggg gtgttcagcg gcaaaaaaga agatttccag      840
gcctgggtag acagtgtgag cgcctcgccg gacttcgtcg atttcgtccc caccatcccc      900
atgcaggaaa tctggaccct gtgcagcagc gaggcgcagg ccgaggccat gcgcaagcat      960
tacgatgacg tctgggcgcc ggcgcaatcg gaaaagttcc gggtcaaggc taactacatc     1020
gaccaactgg tggtcctcac cggcggtagt tcaaccatcg aaccaccggt cggctacagc     1080
aagatcgagt acgacctcaa tgccggtgcc ggcggtgact tcatctactt gtgctatcac     1140
gaacaaacct ggcaggccga caggcctaaa gatgctgtga cggatatcag gatcattttc     1200
aacaaggagc ctaccccacc tggctatacc aagctgcccc aggacctgaa caagggcgcg     1260
ggcggtgatg atgtattcct ctgctacaag accgaggctt tcaacaccga caccgcaatc     1320
aacaaggtca cggtcatcgg cggcaacaat gcggatatca acgctccctt tggttatctg     1380
aaggtccccg gtgacctcaa cagaggtgct ggcggcaact tcatctatgc ctgtaccttc     1440
gtaggcaag                                                             1449

<210>  262
<211>  1449
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  262
atggaaaaca tagacttgcc acaaggactt gtaaactttt ccacgcaaca cctgcaactt       60
attcgtttta aagcaggttt gaatgaaacc gtactacctg gcgtcgaagc cattggactt      120
ggctataacc cattcatcag ttatgccagt gtcaacagcg gcgcggtgca attgttcgac      180
tgggccacgg ccaagaaacg cgaagtgcct ttcaaagccg gctacttcgt acccgagctc      240
gtcgacgtgc aacagaacga cagcgcaacc ttcaccaacg tcagcggcaa cacgatcagc      300
gagtaccagc gcagtctggc taccagcgtc gccatcgaag gccgttacaa cttcttcagt      360
ggctcgctgt ccacggattt cgacagtaat tcactgcgca acgcggaaaa cgagttcact      420
cgcattcagc aatcgatcaa cctctggtcg ttgcgcttgc cttcggtgaa gtcattgcgc      480
gaactgatgc tgccacacat gcgccaacaa ctagatgaat tgaacgtcaa cgacccgaag      540
gccataagcc gctatttcga tagagttggc agccatttcc ttaccggcat cgtaatgggt      600
ggacgggcca tcctcgcctc ctcgaccaac aagctcaggg tcaagcgtga ctactcggtg      660
tcggtggtcg ccaaggcgag ctacgaaggg cttaccggcc agttgagcgc agaagccaaa      720
gccaagtatg gcgagtcgat cagcagcttc actcagtact ccaataccca ccaggaagtg      780
cgcggcggcg acggtgccaa ggcacatggg gtgttcagcg gcaaaaaaga agatttccag      840
gcctgggtag acagtgtgag cgcctcgccg gacttcgtcg atttcgtccc caccatcccc      900
atgcaggaaa tctggaccct gtgcagcagc gaggcgcagg ccgaggccat gcgcaagcat      960
tacgatgacg tctgggcgcc ggcgcaatcg gaaaagtacc gggtcaaggc taacttcatc     1020
gaccaactgg tggtcctcac cggcggtagt tcaaccatcg aaccaccggt cggctacagc     1080
aagatcgagt acgacctcaa tgccggtgcc ggcggtgact tcatctactt gtgctatcac     1140
gaacaaacct ggcaggccga caggcctaaa gatgctgtga cggatatcag gatcattttc     1200
aacaaggagc ctaccccacc tggctatacc aagctgcccc aggacctgaa caagggcgcg     1260
ggcggtgatg atgtattcct ctgctacaag accgaggctt tcaacaccga caccgcaatc     1320
aacaaggtca cggtcatcgg cggcaacaat gcggatatca acgctcccta tggttatctg     1380
aaggtccccg gtgacctcaa cagaggtgct ggcggcaact tcatctatgc ctgtaccttc     1440
gtaggcaag                                                             1449

<210>  263
<211>  1449
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  263
atggaaaaca tagacttgcc acaaggactt gtaaactttt ccacgcaaca cctgcaactt       60
attcgtttta aagcaggttt gaatgaaacc gtactacctg gcgtcgaagc cattggactt      120
ggctataacc cattcatcag ttatgccagt gtcaacagcg gcgcggtgca attgttcgac      180
tgggccacgg ccaagaaacg cgaagtgcct ttcaaagccg gctacttcgt acccgagctc      240
gtcgacgtgc aacagaacga cagcgcaacc tacaccaacg tcagcggcaa cacgctcagc      300
gagtaccagc gcagtctggc taccagcgtc gccatcgaag gccgttacaa cttcttcagt      360
ggctcgctgt ccacggattt cgacagtaat tcactgcgca acgcggaaaa cgagttcact      420
cgcattcagc aatcgatcaa cctctggtcg ttgcgcttgc cttcggtgaa gtcattgcgc      480
gaactgatgc tgccacacat gcgccaacaa ctagatgaat tgaacgtcaa cgacccgaag      540
gccataagcc gctatttcga tagagttggc agccatttcc ttaccggcat cgtaatgggt      600
ggacgggcca tcctcgcctc ctcgaccaac aagctcaggg tcaagcgtga ctactcggtg      660
tcggtggtcg ccaaggcgag ctacgaaggg cttaccggcc agttgagcgc agaagccaaa      720
gccaagtatg gcgagtcgat cagcagcttc actcagtact ccaataccca ccaggaagtg      780
cgcggcggcg acggtgccaa ggcacatggg gtgttcagcg gcaaaaaaga agatttccag      840
gcctgggtag acagtgtgag cgcctcgccg gacttcgtcg atttcgtccc caccatcccc      900
atgcaggaaa tctggaccct gtgcagcagc gaggcgcagg ccgaggccat gcgcaagcat      960
tacgatgacg tctgggcgcc ggcgcaatcg gaaaagttcc gggtcaaggc taactacatc     1020
gaccaactgg tggtcatcac cggcggtagt tcaaccatcg aaccaccggt cggctacagc     1080
aagctcgagt acgacctcaa tgccggtgcc ggcggtgact tcatctactt gtgctatcac     1140
gaacaaacct ggcaggccga caggcctaaa gatgctgtga cggatatcag gatcattttc     1200
aacaaggagc ctaccccacc tggctatacc aagctgcccc aggacctgaa caagggcgcg     1260
ggcggtgatg atgtattcct ctgctacaag accgaggctt tcaacaccga caccgcaatc     1320
aacaaggtca cggtcatcgg cggcaacaat gcggatatca acgctcccta tggttatctg     1380
aaggtccccg gtgacctcaa cagaggtgct ggcggcaact tcatctatgc ctgtaccttc     1440
gtaggcaag                                                             1449

<210>  264
<211>  1449
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  264
atggaaaaca tagacttgcc acaaggactt gtaaactttt ccacgcaaca cctgcaactt       60
attcgtttta aagcaggttt gaatgaaacc gtactacctg gcgtcgaagc cattggactt      120
ggctataacc cattcatcag ttatgccagt gtcaacagcg gcgcggtgca attgttcgac      180
tgggccacgg ccaagaaacg cgaagtgcct ttcaaagccg gctacttcgt acccgagctc      240
gtcgacgtgc aacagaacga cagcgcaacc ttcaccaacg tcagcggcaa cacgatcagc      300
gagtaccagc gcagtctggc taccagcgtc gccatcgaag gccgttacaa cttcttcagt      360
ggctcgctgt ccacggattt cgacagtaat tcactgcgca acgcggaaaa cgagttcact      420
cgcattcagc aatcgatcaa cctctggtcg ttgcgcttgc cttcggtgaa gtcattgcgc      480
gaactgatgc tgccacacat gcgccaacaa ctagatgaat tgaacgtcaa cgacccgaag      540
gccataagcc gctatttcga tagagttggc agccatttcc ttaccggcat cgtaatgggt      600
ggacgggcca tcctcgcctc ctcgaccaac aagctcaggg tcaagcgtga ctactcggtg      660
tcggtggtcg ccaaggcgag ctacgaaggg cttaccggcc agttgagcgc agaagccaaa      720
gccaagtatg gcgagtcgat cagcagcttc actcagtact ccaataccca ccaggaagtg      780
cgcggcggcg acggtgccaa ggcacatggg gtgttcagcg gcaaaaaaga agatttccag      840
gcctgggtag acagtgtgag cgcctcgccg gacttcgtcg atttcgtccc caccatcccc      900
atgcaggaaa tctggaccct gtgcagcagc gaggcgcagg ccgaggccat gcgcaagcat      960
tacgatgacg tctgggcgcc ggcgcaatcg gaaaagttcc gggtcaaggc taactacatc     1020
gaccaactgg tggtcatcac cggcggtagt tcaaccatcg aaccaccggt cggctacagc     1080
aagatcgagt acgacctcaa tgccggtgcc ggcggtgact tcatctactt gtgctatcac     1140
gaacaaacct ggcaggccga caggcctaaa gatgctgtga cggatatcag gatcattttc     1200
aacaaggagc ctaccccacc tggctatacc aagctgcccc aggacctgaa caagggcgcg     1260
ggcggtgatg atgtattcct ctgctacaag accgaggctt acaacaccga caccgcaatc     1320
aacaaggtca cggtcatcgg cggcaacaat gcggatatca acgctcccta tggttatctg     1380
aaggtccccg gtgacctcaa cagaggtgct ggcggcaact tcatctatgc ctgtaccttc     1440
gtaggcaag                                                             1449

<210>  265
<211>  1449
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  265
atggaaaaca tagacttgcc acaaggactt gtaaactttt ccacgcaaca cctgcaactt       60
attcgtttta aagcaggttt gaatgaaacc gtactacctg gcgtcgaagc cattggactt      120
ggctataacc cattcatcag ttatgccagt gtcaacagcg gcgcggtgca attgttcgac      180
tgggccacgg ccaagaaacg cgaagtgcct ttcaaagccg gctacttcgt acccgagctc      240
gtcgacgtgc aacagaacga cagcgcaacc ttcaccaacg tcagcggcaa cacgctcagc      300
gagtaccagc gcagtctggc taccagcgtc gccatcgaag gccgttacaa cttcttcagt      360
ggctcgctgt ccacggattt cgacagtaat tcactgcgca acgcggaaaa cgagttcact      420
cgcattcagc aatcgatcaa cctctggtcg ttgcgcttgc cttcggtgaa gtcattgcgc      480
gaactgatgc tgccacacat gcgccaacaa ctagatgaat tgaacgtcaa cgacccgaag      540
gccataagcc gctatttcga tagagttggc agccatttcc ttaccggcat cgtaatgggt      600
ggacgggcca tcctcgcctc ctcgaccaac aagctcaggg tcaagcgtga ctactcggtg      660
tcggtggtcg ccaaggcgag ctacgaaggg cttaccggcc agttgagcgc agaagccaaa      720
gccaagtatg gcgagtcgat cagcagcttc actcagtact ccaataccca ccaggaagtg      780
cgcggcggcg acggtgccaa ggcacatggg gtgttcagcg gcaaaaaaga agatttccag      840
gcctgggtag acagtgtgag cgcctcgccg gacttcgtcg atttcgtccc caccatcccc      900
atgcaggaaa tctggaccct gtgcagcagc gaggcgcagg ccgaggccat gcgcaagcat      960
tacgatgacg tctgggcgcc ggcgcaatcg gaaaagttcc gggtcaaggc taacttcatc     1020
gaccaactgg tggtcctcac cggcggtagt tcaaccctcg aaccaccggt cggctacagc     1080
aagctcgagt acgacctcaa tgccggtgcc ggcggtgact tcatctactt gtgctatcac     1140
gaacaaacct ggcaggccga caggcctaaa gatgctgtga cggatatcag gatcattttc     1200
aacaaggagc ctaccccacc tggctatacc aagctgcccc aggacctgaa caagggcgcg     1260
ggcggtgatg atgtattcct ctgctacaag accgaggctt acaacaccga caccgcactc     1320
aacaaggtca cggtcatcgg cggcaacaat gcggatatca acgctcccta tggttatctg     1380
aaggtccccg gtgacctcaa cagaggtgct ggcggcaact tcatctatgc ctgtaccttc     1440
gtaggcaag                                                             1449

<210>  266
<211>  1449
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  266
atggaaaaca tagacttgcc acaaggactt gtaaactttt ccacgcaaca cctgcaactt       60
attcgtttta aagcaggttt gaatgaaacc gtactacctg gcgtcgaagc cattggactt      120
ggctataacc cattcatcag ttatgccagt gtcaacagcg gcgcggtgca attgttcgac      180
tgggccacgg ccaagaaacg cgaagtgcct ttcaaagccg gctacttcgt acccgagctc      240
gtcgacgtgc aacagaacga cagcgcaacc ttcaccaacg tcagcggcaa cacgctcagc      300
gagtaccagc gcagtctggc taccagcgtc gccatcgaag gccgttacaa cttcttcagt      360
ggctcgctgt ccacggattt cgacagtaat tcactgcgca acgcggaaaa cgagttcact      420
cgcattcagc aatcgatcaa cctctggtcg ttgcgcttgc cttcggtgaa gtcattgcgc      480
gaactgatgc tgccacacat gcgccaacaa ctagatgaat tgaacgtcaa cgacccgaag      540
gccataagcc gctatttcga tagagttggc agccatttcc ttaccggcat cgtaatgggt      600
ggacgggcca tcctcgcctc ctcgaccaac aagctcaggg tcaagcgtga ctactcggtg      660
tcggtggtcg ccaaggcgag ctacgaaggg cttaccggcc agttgagcgc agaagccaaa      720
gccaagtatg gcgagtcgat cagcagcttc actcagtact ccaataccca ccaggaagtg      780
cgcggcggcg acggtgccaa ggcacatggg gtgttcagcg gcaaaaaaga agatttccag      840
gcctgggtag acagtgtgag cgcctcgccg gacttcgtcg atttcgtccc caccatcccc      900
atgcaggaaa tctggaccct gtgcagcagc gaggcgcagg ccgaggccat gcgcaagcat      960
ttcgatgacg tctgggcgcc ggcgcaatcg gaaaagttcc gggtcaaggc taacttcatc     1020
gaccaactgg tggtcctcac cggcggtagt tcaaccatcg aaccaccggt cggctacagc     1080
aagatcgagt acgacctcaa tgccggtgcc ggcggtgact tcatctactt gtgctatcac     1140
gaacaaacct ggcaggccga caggcctaaa gatgctgtga cggatatcag gatcattttc     1200
aacaaggagc ctaccccacc tggctatacc aagctgcccc aggacctgaa caagggcgcg     1260
ggcggtgatg atgtattcct ctgctacaag accgaggctt tcaacaccga caccgcaatc     1320
aacaaggtca cggtcatcgg cggcaacaat gcggatctca acgctcccta tggttatctg     1380
aaggtccccg gtgacctcaa cagaggtgct ggcggcaact tcatctatgc ctgtaccttc     1440
gtaggcaag                                                             1449

<210>  267
<211>  1449
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  267
atggaaaaca tagacttgcc acaaggactt gtaaactttt ccacgcaaca cctgcaactt       60
attcgtttta aagcaggttt gaatgaaacc gtactacctg gcgtcgaagc cattggactt      120
ggctataacc cattcatcag ttatgccagt gtcaacagcg gcgcggtgca attgttcgac      180
tgggccacgg ccaagaaacg cgaagtgcct ttcaaagccg gctacttcgt acccgagctc      240
gtcgacgtgc aacagaacga cagcgcaacc tacaccaacg tcagcggcaa cacgatcagc      300
gagtaccagc gcagtctggc taccagcgtc gccatcgaag gccgttacaa cttcttcagt      360
ggctcgctgt ccacggattt cgacagtaat tcactgcgca acgcggaaaa cgagttcact      420
cgcattcagc aatcgatcaa cctctggtcg ttgcgcttgc cttcggtgaa gtcattgcgc      480
gaactgatgc tgccacacat gcgccaacaa ctagatgaat tgaacgtcaa cgacccgaag      540
gccataagcc gctatttcga tagagttggc agccatttcc ttaccggcat cgtaatgggt      600
ggacgggcca tcctcgcctc ctcgaccaac aagctcaggg tcaagcgtga ctactcggtg      660
tcggtggtcg ccaaggcgag ctacgaaggg cttaccggcc agttgagcgc agaagccaaa      720
gccaagtatg gcgagtcgat cagcagcttc actcagtact ccaataccca ccaggaagtg      780
cgcggcggcg acggtgccaa ggcacatggg gtgttcagcg gcaaaaaaga agatttccag      840
gcctgggtag acagtgtgag cgcctcgccg gacttcgtcg atttcgtccc caccatcccc      900
atgcaggaaa tctggaccct gtgcagcagc gaggcgcagg ccgaggccat gcgcaagcat      960
ttcgatgacg tctgggcgcc ggcgcaatcg gaaaagttcc gggtcaaggc taactacatc     1020
gaccaactgg tggtcatcac cggcggtagt tcaaccatcg aaccaccggt cggctacagc     1080
aagatcgagt acgacctcaa tgccggtgcc ggcggtgact tcatctactt gtgctatcac     1140
gaacaaacct ggcaggccga caggcctaaa gatgctgtga cggatatcag gatcattttc     1200
aacaaggagc ctaccccacc tggctatacc aagctgcccc aggacctgaa caagggcgcg     1260
ggcggtgatg atgtattcct ctgctacaag accgaggctt tcaacaccga caccgcaatc     1320
aacaaggtca cggtcctcgg cggcaacaat gcggatatca acgctcccta tggttatctg     1380
aaggtccccg gtgacctcaa cagaggtgct ggcggcaact tcatctatgc ctgtaccttc     1440
gtaggcaag                                                             1449

<210>  268
<211>  1449
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  268
atggaaaaca tagacttgcc acaaggactt gtaaactttt ccacgcaaca cctgcaactt       60
attcgtttta aagcaggttt gaatgaaacc gtactacctg gcgtcgaagc cattggactt      120
ggctataacc cattcatcag ttatgccagt gtcaacagcg gcgcggtgca attgttcgac      180
tgggccacgg ccaagaaacg cgaagtgcct ttcaaagccg gctacttcgt acccgagctc      240
gtcgacgtgc aacagaacga cagcgcaacc ttcaccaacg tcagcggcaa cacgatcagc      300
gagtaccagc gcagtctggc taccagcgtc gccatcgaag gccgttacaa cttcttcagt      360
ggctcgctgt ccacggattt cgacagtaat tcactgcgca acgcggaaaa cgagttcact      420
cgcattcagc aatcgatcaa cctctggtcg ttgcgcttgc cttcggtgaa gtcattgcgc      480
gaactgatgc tgccacacat gcgccaacaa ctagatgaat tgaacgtcaa cgacccgaag      540
gccataagcc gctatttcga tagagttggc agccatttcc ttaccggcat cgtaatgggt      600
ggacgggcca tcctcgcctc ctcgaccaac aagctcaggg tcaagcgtga ctactcggtg      660
tcggtggtcg ccaaggcgag ctacgaaggg cttaccggcc agttgagcgc agaaaccaaa      720
gccaagtatg gcgagtcgat cagcagcttc actcagtact ccaataccca ccaggaagtg      780
cgcggcggcg acggtgccaa ggcacatggg gtgttcagcg gcaaaaaaga agatttccag      840
gcctgggtag acagtgtgag cgcctcgccg gacttcgtcg atttcgtccc caccatcccc      900
atgcaggaaa tctggaccct gtgcagcagc gaggcgcagg ccgaggccat gcgcaagcat      960
tacgatgacg tctgggcgcc ggcgcaatcg gaaaagtacc gggtcaaggc taacttcatc     1020
gaccaactgg tggtcatcac cggcggtagt tcaaccatcg aaccaccggt cggctacagc     1080
aagatcgagt acgacctcaa tgccggtgcc ggcggtgact tcatctactt gtgctatcac     1140
gaacaaacct ggcaggccga caggcctaaa gatgctgtga cggatatcag gatcattttc     1200
aacaaggagc ctaccccacc tggctatacc aagctgcccc aggacctgaa caagggcgcg     1260
ggcggtgatg atgtattcct ctgctacaag accgaggctt acaacaccga caccgcaatc     1320
aacaaggtca cggtcatcgg cggcaacaat gcggatctca acgctcccta tggttatctg     1380
aaggtccccg gtgacctcaa cagaggtgct ggcggcaact tcatctatgc ctgtaccttc     1440
gtaggcaag                                                             1449

<210>  269
<211>  1449
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  269
atggaaaaca tagacttgcc acaaggactt gtaaactttt ccacgcaaca cctgcaactt       60
attcgtttta aagcaggttt gaatgaaacc gtactacctg gcgtcgaagc cattggactt      120
ggctataacc cattcatcag ttatgccagt gtcaacagcg gcgcggtgca attgttcgac      180
tgggccacgg ccaagaaacg cgaagtgcct ttcaaagccg gctacttcgt acccgagctc      240
gtcgacgtgc aacagaacga cagcgcaacc tacaccaacg tcagcggcaa cacgatcagc      300
gagtaccagc gcagtctggc taccagcgtc gccatcgaag gccgttacaa cttcttcagt      360
ggctcgctgt ccacggattt cgacagtaat tcactgcgca acgcggaaaa cgagttcact      420
cgcattcagc aatcgatcaa cctctggtcg ttgcgcttgc cttcggtgaa gtcattgcgc      480
gaactgatgc tgccacacat gcgccaacaa ctagatgaat tgaacgtcaa cgacccgaag      540
gccataagcc gctatttcga tagagttggc agccatttcc ttaccggcat cgtaatgggt      600
ggacgggcca tcctcgcctc ctcgaccaac aagctcaggg tcaagcgtga ctactcggtg      660
tcggtggtcg ccaaggcgag ctacgaaggg cttaccggcc agttgagcgc agaagccaaa      720
gccaagtatg gcgagtcgat cagcagcttc actcagtact ccaataccca ccaggaagtg      780
cgcggcggcg acggtgccaa ggcacatggg gtgttcagcg gcaaaaaaga agatttccag      840
gcctgggtag acagtgtgag cgcctcgccg gacttcgtcg atttcgtccc caccatcccc      900
atgcaggaaa tctggaccct gtgcagcagc gaggcgcagg ccgaggccat gcgcaagcat      960
tacgatgacg tctgggcgcc ggcgcaatcg gaaaagttcc gggtcaaggc taactacatc     1020
gaccaactgg tggtcatcac cggcggtagt tcaaccatcg aaccaccggt cggctacagc     1080
aagatcgagt acgacctcaa tgccggtgcc ggcggtgact tcatctactt gtgctatcac     1140
gaacaaacct ggcaggccga caggcctaaa gatgctgtga cggatatcag gatcattttc     1200
aacaaggagc ctaccccacc tggctatacc aagctgcccc aggacctgaa caagggcgcg     1260
ggcggtgatg atgtattcct ctgctacaag accgaggctt tcaacaccga caccgcaatc     1320
aacaaggtca cggtcatcgg cggcaacaat gcggatatca acgctccctt tggttatctg     1380
aaggtccccg gtgacctcaa cagaggtgct ggcggcaact tcatctatgc ctgtaccttc     1440
gtaggcaag                                                             1449

<210>  270
<211>  1449
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  270
atggaaaaca tagacttgcc acaaggactt gtaaactttt ccacgcaaca cctgcaactt       60
attcgtttta aagcaggttt gaatgaaacc gtactacctg gcgtcgaagc cattggactt      120
ggctataacc cattcatcag ttatgccagt gtcaacagcg gcgcggtgca attgttcgac      180
tgggccacgg ccaagaaacg cgaagtgcct ttcaaagccg gctacttcgt acccgagctc      240
gtcgacgtgc aacagaacga cagcgcaacc tacaccaacg tcagcggcaa cacgatcagc      300
gagtaccagc gcagtctggc taccagcgtc gccatcgaag gccgttacaa cttcttcagt      360
ggctcgctgt ccacggattt cgacagtaat tcactgcgca acgcggaaaa cgagttcact      420
cgcattcagc aatcgatcaa cctctggtcg ttgcgcttgc cttcggtgaa gtcattgcgc      480
gaactgatgc tgccacacat gcgccaacaa ctagatgaat tgaacgtcaa cgacccgaag      540
gccataagcc gctatttcga tagagttggc agccatttcc ttaccggcat cgtaatgggt      600
ggacgggcca tcctcgcctc ctcgaccaac aagctcaggg tcaagcgtga ctactcggtg      660
tcggtggtcg ccaaggcgag ctacgaaggg cttaccggcc agttgagcgc agaagccaaa      720
gccaagtatg gcgagtcgat cagcagcttc actcagtact ccaataccca ccaggaagtg      780
cgcggcggcg acggtgccaa ggcacatggg gtgttcagcg gcaaaaaaga agatttccag      840
gcctgggtag acagtgtgag cgcctcgccg gacttcgtcg atttcgtccc caccatcccc      900
atgcaggaaa tctggaccct gtgcagcagc gaggcgcagg ccgaggccat gcgcaagcat      960
ttcgatgacg tctgggcgcc ggcgcaatcg gaaaagttcc gggtcaaggc taactacatc     1020
gaccaactgg tggtcatcac cggcggtagt tcaaccatcg aaccaccggt cggctacagc     1080
aagatcgagt acgacctcaa tgccggtgcc ggcggtgact tcatctactt gtgctatcac     1140
gaacaaacct ggcaggccga caggcctaaa gatgctgtga cggatatcag gatcattttc     1200
aacaaggagc ctaccccacc tggctatacc aagctgcccc aggacctgaa caagggcgcg     1260
ggcggtgatg atgtattcct ctgctacaag accgaggctt acaacaccga caccgcaatc     1320
aacaaggtca cggtcatcgg cggcaacaat gcggatctca acgctcccta tggttatctg     1380
aaggtccccg gtgacctcaa cagaggtgct ggcggcaact tcatctatgc ctgtaccttc     1440
gtaggcaag                                                             1449

<210>  271
<211>  1449
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  271
atggaaaaca tagacttgcc acaaggactt gtaaactttt ccacgcaaca cctgcaactt       60
attcgtttta aagcaggttt gaatgaaacc gtactacctg gcgtcgaagc cattggactt      120
ggctataacc cattcatcag ttatgccagt gtcaacagcg gcgcggtgca attgttcgac      180
tgggccacgg ccaagaaacg cgaagtgcct ttcaaagccg gctacttcgt acccgagctc      240
gtcgacgtgc aacagaacga cagcgcaacc ttcaccaacg tcagcggcaa cacgatcagc      300
gagtaccagc gcagtctggc taccagcgtc gccatcgaag gccgttacaa cttcttcagt      360
ggctcgctgt ccacggattt cgacagtaat tcactgcgca acgcggaaaa cgagttcact      420
cgcattcagc aatcgatcaa cctctggtcg ttgcgcttgc cttcggtgaa gtcattgcgc      480
gaactgatgc tgccacacat gcgccaacaa ctagatgaat tgaacgtcaa cgacccgaag      540
gccataagcc gctatttcga tagagttggc agccatttcc ttaccggcat cgtaatgggt      600
ggacgggcca tcctcgcctc ctcgaccaac aagctcaggg tcaagcgtga ctactcggtg      660
tcggtggtcg ccaaggcgag ctacgaaggg cttaccggcc agttgagcgc agaagccaaa      720
gccaagtatg gcgagtcgat cagcagcttc actcagtact ccaataccca ccaggaagtg      780
cgcggcggcg acggtgccaa ggcacatggg gtgttcagcg gcaaaaaaga agatttccag      840
gcctgggtag acagtgtgag cgcctcgccg gacttcgtcg atttcgtccc caccatcccc      900
atgcaggaaa tctggaccct gtgcagcagc gaggcgcagg ccgaggccat gcgcaagcat      960
tacgatgacg tctgggcgcc ggcgcaatcg gaaaagttcc gggtcaaggc taactacatc     1020
gaccaactgg tggtcatcac cggcggtagt tcaaccctcg aaccaccggt cggctacagc     1080
aagatcgagt acgacctcaa tgccggtgcc ggcggtgact tcatctactt gtgctatcac     1140
gaacaaacct ggcaggccga caggcctaaa gatgctgtga cggatatcag gatcattttc     1200
aacaaggagc ctaccccacc tggctatacc aagctgcccc aggacctgaa caagggcgcg     1260
ggcggtgatg atgtattcct ctgctacaag accgaggctt acaacaccga caccgcaatc     1320
aacaaggtca cggtcatcgg cggcaacaat gcggatatca acgctcccta tggttatctg     1380
aaggtccccg gtgacctcaa cagaggtgct ggcggcaact tcatctatgc ctgtaccttc     1440
gtaggcaag                                                             1449

<210>  272
<211>  1449
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  272
atggaaaaca tagacttgcc acaaggactt gtaaactttt ccacgcaaca cctgcaactt       60
attcgtttta aagcaggttt gaatgaaacc gtactacctg gcgtcgaagc cattggactt      120
ggctataacc cattcatcag ttatgccagt gtcaacagcg gcgcggtgca attgttcgac      180
tgggccacgg ccaagaaacg cgaagtgcct ttcaaagccg gctacttcgt acccgagctc      240
gtcgacgtgc aacagaacga cagcgcaacc tacaccaacg tcagcggcaa cacgctcagc      300
gagtaccagc gcagtctggc taccagcgtc gccatcgaag gccgttacaa cttcttcagt      360
ggctcgctgt ccacggattt cgacagtaat tcactgcgca acgcggaaaa cgagttcact      420
cgcattcagc aatcgatcaa cctctggtcg ttgcgcttgc cttcggtgaa gtcattgcgc      480
gaactgatgc tgccacacat gcgccaacaa ctagatgaat tgaacgtcaa cgacccgaag      540
gccataagcc gctatttcga tagagttggc agccatttcc ttaccggcat cgtaatgggt      600
ggacgggcca tcctcgcctc ctcgaccaac aagctcaggg tcaagcgtga ctactcggtg      660
tcggtggtcg ccaaggcgag ctacgaaggg cttaccggcc agttgagcgc agaagccaaa      720
gccaagtatg gcgagtcgat cagcagcttc actcagtact ccaataccca ccaggaagtg      780
cgcggcggcg acggtgccaa ggcacatggg gtgttcagcg gcaaaaaaga agatttccag      840
gcctgggtag acagtgtgag cgcctcgccg gacttcgtcg atttcgtccc caccatcccc      900
atgcaggaaa tctggaccct gtgcagcagc gaggcgcagg ccgaggccat gcgcaagcat      960
tacgatgacg tctgggcgcc ggcgcaatcg gaaaagttcc gggtcaaggc taactacatc     1020
gaccaactgg tggtcatcac cggcggtagt tcaaccctcg aaccaccggt cggctacagc     1080
aagatcgagt acgacctcaa tgccggtgcc ggcggtgact tcatctactt gtgctatcac     1140
gaacaaacct ggcaggccga caggcctaaa gatgctgtga cggatatcag gatcattttc     1200
aacaaggagc ctaccccacc tggctatacc aagctgcccc aggacctgaa caagggcgcg     1260
ggcggtgatg atgtattcct ctgctacaag accgaggctt acaacaccga caccgcactc     1320
aacaaggtca cggtcatcgg cggcaacaat gcggatatca acgctcccta tggttatctg     1380
aaggtccccg gtgacctcaa cagaggtgct ggcggcaact tcatctatgc ctgtaccttc     1440
gtaggcaag                                                             1449

<210>  273
<211>  1449
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  273
atggaaaaca tagacttgcc acaaggactt gtaaactttt ccacgcaaca cctgcaactt       60
attcgtttta aagcaggttt gaatgaaacc gtactacctg gcgtcgaagc cattggactt      120
ggctataacc cattcatcag ttatgccagt gtcaacagcg gcgcggtgca attgttcgac      180
tgggccacgg ccaagaaacg cgaagtgcct ttcaaagccg gctacttcgt acccgagctc      240
gtcgacgtgc aacagaacga cagcgcaacc ttcaccaacg tcagcggcaa cacgatcagc      300
gagtaccagc gcagtctggc taccagcgtc gccatcgaag gccgttacaa cttcttcagt      360
ggctcgctgt ccacggattt cgacagtaat tcactgcgca acgcggaaaa cgagttcact      420
cgcattcagc aatcgatcaa cctctggtcg ttgcgcttgc cttcggtgaa gtcattgcgc      480
gaactgatgc tgccacacat gcgccaacaa ctagatgaat tgaacgtcaa cgacccgaag      540
gccataagcc gctatttcga tagagttggc agccatttcc ttaccggcat cgtaatgggt      600
ggacgggcca tcctcgcctc ctcgaccaac aagctcaggg tcaagcgtga ctactcggtg      660
tcggtggtcg ccaaggcgag ctacgaaggg cttaccggcc agttgagcgc agaagccaaa      720
gccaagtatg gcgagtcgat cagcagcttc actcagtact ccaataccca ccaggaagtg      780
cgcggcggcg acggtgccaa ggcacatggg gtgttcagcg gcaaaaaaga agatttccag      840
gcctgggtag acagtgtgag cgcctcgccg gacttcgtcg atttcgtccc caccatcccc      900
atgcaggaaa tctggaccct gtgcagcagc gaggcgcagg ccgaggccat gcgcaagcat      960
tacgatgacg tctgggcgcc ggcgcaatcg gaaaagttcc gggtcaaggc taactacatc     1020
gaccaactgg tggtcatcac cggcggtagt tcaaccatcg aaccaccggt cggctacagc     1080
aagatcgagt acgacctcaa tgccggtgcc ggcggtgact tcatctactt gtgctatcac     1140
gaacaaacct ggcaggccga caggcctaaa gatgctgtga cggatatcag gatcattttc     1200
aacaaggagc ctaccccacc tggctatacc aagctgcccc aggacctgaa caagggcgcg     1260
ggcggtgatg atgtattcct ctgctacaag accgaggctt acaacaccga caccgcaatc     1320
aacaaggtca cggtcctcgg cggcaacaat gcggatatca acgctcccta tggttatctg     1380
aaggtccccg gtgacctcaa cagaggtgct ggcggcaact tcatctatgc ctgtaccttc     1440
gtaggcaag                                                             1449

<210>  274
<211>  491
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  274
Met Glu Asn Ile Asp Leu Pro Gln Gly Leu Val Asn Phe Ser Thr Gln 
1               5                   10                  15      
His Leu Gln Leu Ile Arg Phe Lys Ala Gly Leu Asn Glu Thr Val Leu 
            20                  25                  30          
Pro Gly Val Glu Ala Leu Gly Leu Gly Tyr Asn Pro Phe Ile Ser Tyr 
        35                  40                  45              
Ala Ser Val Asn Ser Gly Ala Val Gln Leu Phe Asp Trp Ala Thr Ala 
    50                  55                  60                  
Lys Lys Arg Glu Val Pro Phe Lys Ala Gly Tyr Phe Val Pro Glu Ile 
65                  70                  75                  80  
Val Asp Val Gln Gln Asn Asp Ser Ala Thr Tyr Thr Asn Val Ser Gly 
                85                  90                  95      
Asn Thr Ile Ser Glu Tyr Gln Arg Ser Leu Ala Thr Ser Val Ala Ile 
            100                 105                 110         
Glu Gly Arg Tyr Asn Phe Phe Ser Gly Ser Leu Ser Thr Asp Phe Asp 
        115                 120                 125             
Ser Asn Ser Leu Arg Asn Ala Glu Asn Glu Phe Thr Arg Ile Gln Gln 
    130                 135                 140                 
Ser Ile Asn Leu Trp Ser Leu Arg Leu Pro Ser Val Lys Ser Leu Arg 
145                 150                 155                 160 
Glu Leu Met Leu Pro His Met Arg Gln Gln Leu Asp Glu Leu Asn Val 
                165                 170                 175     
Asn Asp Pro Lys Ala Ile Ser Arg Tyr Phe Asp Arg Val Gly Ser His 
            180                 185                 190         
Phe Leu Thr Gly Ile Val Met Gly Gly Arg Ala Ile Leu Ala Ser Ser 
        195                 200                 205             
Thr Asn Lys Leu Arg Val Lys Arg Asp Tyr Ser Val Ser Val Val Ala 
    210                 215                 220                 
Lys Ala Ser Tyr Glu Gly Leu Thr Gly Gln Leu Ser Ala Glu Ala Lys 
225                 230                 235                 240 
Ala Lys Tyr Gly Glu Ser Ile Ser Ser Phe Thr Gln Tyr Ser Asn Thr 
                245                 250                 255     
His Gln Glu Val Arg Gly Gly Asp Gly Ala Lys Ala His Gly Val Phe 
            260                 265                 270         
Ser Gly Lys Lys Glu Asp Phe Gln Ala Trp Val Asp Ser Val Ser Ala 
        275                 280                 285             
Ser Pro Asp Phe Val Asp Phe Val Pro Thr Ile Pro Met Gln Glu Ile 
    290                 295                 300                 
Trp Thr Leu Cys Ser Ser Glu Ala Gln Ala Glu Ala Met Arg Lys His 
305                 310                 315                 320 
Tyr Asp Asp Val Trp Ala Pro Ala Gln Ser Glu Lys Tyr Arg Val Lys 
                325                 330                 335     
Ala Asn Tyr Ile Asp Gln Leu Val Val Ile Thr Gly Gly Ser Ser Thr 
            340                 345                 350         
Ile Glu Pro Pro Val Gly Tyr Ser Lys Ile Glu Tyr Asp Leu Asn Ala 
        355                 360                 365             
Gly Ala Gly Gly Asp Phe Ile Tyr Leu Cys Tyr His Glu Gln Thr Trp 
    370                 375                 380                 
Gln Ala Asp Arg Pro Lys Asp Ala Val Thr Asp Ile Arg Ile Ile Phe 
385                 390                 395                 400 
Asn Lys Glu Pro Thr Pro Pro Gly Tyr Thr Lys Leu Pro Gln Asp Leu 
                405                 410                 415     
Asn Lys Gly Ala Gly Gly Asp Asp Val Phe Leu Cys Tyr Lys Thr Glu 
            420                 425                 430         
Ala Tyr Asn Thr Asp Thr Ala Ile Asn Lys Val Thr Val Ile Gly Gly 
        435                 440                 445             
Asn Asn Ala Asp Ile Asn Ala Pro Tyr Gly Tyr Leu Lys Val Pro Gly 
    450                 455                 460                 
Asp Leu Asn Arg Gly Ala Gly Gly Asn Phe Ile Tyr Ala Cys Thr Phe 
465                 470                 475                 480 
Val Gly Lys Leu Glu His His His His His His 
                485                 490     

<210>  275
<211>  491
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  275
Met Glu Asn Leu Asp Leu Pro Gln Gly Leu Val Asn Phe Ser Thr Gln 
1               5                   10                  15      
His Leu Gln Leu Ile Arg Phe Lys Ala Gly Leu Asn Glu Thr Val Leu 
            20                  25                  30          
Pro Gly Val Glu Ala Leu Gly Leu Gly Tyr Asn Pro Phe Ile Ser Tyr 
        35                  40                  45              
Ala Ser Val Asn Ser Gly Ala Val Gln Leu Phe Asp Trp Ala Thr Ala 
    50                  55                  60                  
Lys Lys Arg Glu Val Pro Phe Lys Ala Gly Tyr Phe Val Pro Glu Ile 
65                  70                  75                  80  
Val Asp Val Gln Gln Asn Asp Ser Ala Thr Tyr Thr Asn Val Ser Gly 
                85                  90                  95      
Asn Thr Ile Ser Glu Tyr Gln Arg Ser Leu Ala Thr Ser Val Ala Ile 
            100                 105                 110         
Glu Gly Arg Tyr Asn Phe Phe Ser Gly Ser Leu Ser Thr Asp Phe Asp 
        115                 120                 125             
Ser Asn Ser Leu Arg Asn Ala Glu Asn Glu Phe Thr Arg Ile Gln Gln 
    130                 135                 140                 
Ser Ile Asn Leu Trp Ser Leu Arg Leu Pro Ser Val Lys Ser Leu Arg 
145                 150                 155                 160 
Glu Leu Met Leu Pro His Met Arg Gln Gln Leu Asp Glu Leu Asn Val 
                165                 170                 175     
Asn Asp Pro Lys Ala Ile Ser Arg Tyr Phe Asp Arg Val Gly Ser His 
            180                 185                 190         
Phe Leu Thr Gly Ile Val Met Gly Gly Arg Ala Ile Leu Ala Ser Ser 
        195                 200                 205             
Thr Asn Lys Leu Arg Val Lys Arg Asp Tyr Ser Val Ser Val Val Ala 
    210                 215                 220                 
Lys Ala Ser Tyr Glu Gly Leu Thr Gly Gln Leu Ser Ala Glu Ala Lys 
225                 230                 235                 240 
Ala Lys Tyr Gly Glu Ser Ile Ser Ser Phe Thr Gln Tyr Ser Asn Thr 
                245                 250                 255     
His Gln Glu Val Arg Gly Gly Asp Gly Ala Lys Ala His Gly Val Phe 
            260                 265                 270         
Ser Gly Lys Lys Glu Asp Phe Gln Ala Trp Val Asp Ser Val Ser Ala 
        275                 280                 285             
Ser Pro Asp Phe Val Asp Phe Val Pro Thr Ile Pro Met Gln Glu Ile 
    290                 295                 300                 
Trp Thr Leu Cys Ser Ser Glu Ala Gln Ala Glu Ala Met Arg Lys His 
305                 310                 315                 320 
Tyr Asp Asp Val Trp Ala Pro Ala Gln Ser Glu Lys Tyr Arg Val Lys 
                325                 330                 335     
Ala Asn Tyr Ile Asp Gln Leu Val Val Ile Thr Gly Gly Ser Ser Thr 
            340                 345                 350         
Ile Glu Pro Pro Val Gly Tyr Ser Lys Ile Glu Tyr Asp Leu Asn Ala 
        355                 360                 365             
Gly Ala Gly Gly Asp Phe Leu Tyr Leu Cys Tyr His Glu Gln Thr Trp 
    370                 375                 380                 
Gln Ala Asp Arg Pro Lys Asp Ala Val Thr Asp Ile Arg Ile Ile Phe 
385                 390                 395                 400 
Asn Lys Glu Pro Thr Pro Pro Gly Tyr Thr Lys Leu Pro Gln Asp Leu 
                405                 410                 415     
Asn Lys Gly Ala Gly Gly Asp Asp Val Phe Leu Cys Tyr Lys Thr Glu 
            420                 425                 430         
Ala Tyr Asn Thr Asp Thr Ala Ile Asn Lys Val Thr Val Ile Gly Gly 
        435                 440                 445             
Asn Asn Ala Asp Ile Asn Ala Pro Tyr Gly Tyr Leu Lys Val Pro Gly 
    450                 455                 460                 
Asp Leu Asn Arg Gly Ala Gly Gly Asn Phe Ile Tyr Ala Cys Thr Phe 
465                 470                 475                 480 
Val Gly Lys Leu Glu His His His His His His 
                485                 490     

<210>  276
<211>  491
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  276
Met Glu Asn Ile Asp Leu Pro Gln Gly Leu Val Asn Phe Ser Thr Gln 
1               5                   10                  15      
His Leu Gln Leu Ile Arg Phe Lys Ala Gly Leu Asn Glu Thr Val Leu 
            20                  25                  30          
Pro Gly Val Glu Ala Ile Gly Leu Gly Tyr Asn Pro Phe Ile Ser Tyr 
        35                  40                  45              
Ala Ser Val Asn Ser Gly Ala Val Gln Leu Phe Asp Trp Ala Thr Ala 
    50                  55                  60                  
Lys Lys Arg Glu Val Pro Phe Lys Ala Gly Tyr Phe Val Pro Glu Ile 
65                  70                  75                  80  
Val Asp Val Gln Gln Asn Asp Ser Ala Thr Tyr Thr Asn Val Ser Gly 
                85                  90                  95      
Asn Thr Ile Ser Glu Tyr Gln Arg Ser Leu Ala Thr Ser Val Ala Ile 
            100                 105                 110         
Glu Gly Arg Tyr Asn Phe Phe Ser Gly Ser Leu Ser Thr Asp Phe Asp 
        115                 120                 125             
Ser Asn Ser Leu Arg Asn Ala Glu Asn Glu Phe Thr Arg Ile Gln Gln 
    130                 135                 140                 
Ser Ile Asn Leu Trp Ser Leu Arg Leu Pro Ser Val Lys Ser Leu Arg 
145                 150                 155                 160 
Glu Leu Met Leu Pro His Met Arg Gln Gln Leu Asp Glu Leu Asn Val 
                165                 170                 175     
Asn Asp Pro Lys Ala Ile Ser Arg Tyr Phe Asp Arg Val Gly Ser His 
            180                 185                 190         
Phe Leu Thr Gly Ile Val Met Gly Gly Arg Ala Ile Leu Ala Ser Ser 
        195                 200                 205             
Thr Asn Lys Leu Arg Val Lys Arg Asp Tyr Ser Val Ser Val Val Ala 
    210                 215                 220                 
Lys Ala Ser Tyr Glu Gly Leu Thr Gly Gln Leu Ser Ala Glu Ala Lys 
225                 230                 235                 240 
Ala Lys Tyr Gly Glu Ser Ile Ser Ser Phe Thr Gln Tyr Ser Asn Thr 
                245                 250                 255     
His Gln Glu Val Arg Gly Gly Asp Gly Ala Lys Ala His Gly Val Phe 
            260                 265                 270         
Ser Gly Lys Lys Glu Asp Phe Gln Ala Trp Val Asp Ser Val Ser Ala 
        275                 280                 285             
Ser Pro Asp Phe Val Asp Phe Val Pro Thr Ile Pro Met Gln Glu Ile 
    290                 295                 300                 
Trp Thr Leu Cys Ser Ser Glu Ala Gln Ala Glu Ala Met Arg Lys His 
305                 310                 315                 320 
Tyr Asp Asp Val Trp Ala Pro Ala Gln Ser Glu Lys Tyr Arg Val Lys 
                325                 330                 335     
Ala Asn Tyr Leu Asp Gln Leu Val Val Ile Thr Gly Gly Ser Ser Thr 
            340                 345                 350         
Ile Glu Pro Pro Val Gly Tyr Ser Lys Ile Glu Tyr Asp Leu Asn Ala 
        355                 360                 365             
Gly Ala Gly Gly Asp Phe Ile Tyr Leu Cys Tyr His Glu Gln Thr Trp 
    370                 375                 380                 
Gln Ala Asp Arg Pro Lys Asp Ala Val Thr Asp Ile Arg Ile Ile Phe 
385                 390                 395                 400 
Asn Lys Glu Pro Thr Pro Pro Gly Tyr Thr Lys Leu Pro Gln Asp Leu 
                405                 410                 415     
Asn Lys Gly Ala Gly Gly Asp Asp Val Phe Leu Cys Tyr Lys Thr Glu 
            420                 425                 430         
Ala Tyr Asn Thr Asp Thr Ala Ile Asn Lys Val Thr Val Ile Gly Gly 
        435                 440                 445             
Asn Asn Ala Asp Ile Asn Ala Pro Tyr Gly Tyr Leu Lys Val Pro Gly 
    450                 455                 460                 
Asp Leu Asn Arg Gly Ala Gly Gly Asn Phe Ile Tyr Ala Cys Thr Phe 
465                 470                 475                 480 
Val Gly Lys Leu Glu His His His His His His 
                485                 490     

<210>  277
<211>  491
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  277
Met Glu Asn Ile Asp Leu Pro Gln Gly Leu Val Asn Phe Ser Thr Gln 
1               5                   10                  15      
His Leu Gln Leu Ile Arg Phe Lys Ala Gly Leu Asn Glu Thr Val Leu 
            20                  25                  30          
Pro Gly Val Glu Ala Ile Gly Leu Gly Tyr Asn Pro Phe Ile Ser Tyr 
        35                  40                  45              
Ala Ser Val Asn Ser Gly Ala Val Gln Leu Phe Asp Trp Ala Thr Ala 
    50                  55                  60                  
Lys Lys Arg Glu Val Pro Phe Lys Ala Gly Tyr Phe Val Pro Glu Ile 
65                  70                  75                  80  
Val Asp Val Gln Gln Asn Asp Ser Ala Thr Tyr Thr Asn Val Ser Gly 
                85                  90                  95      
Asn Thr Ile Ser Glu Tyr Gln Arg Ser Leu Ala Thr Ser Val Ala Ile 
            100                 105                 110         
Glu Gly Arg Tyr Asn Phe Phe Ser Gly Ser Leu Ser Thr Asp Phe Asp 
        115                 120                 125             
Ser Asn Ser Leu Arg Asn Ala Glu Asn Glu Phe Thr Arg Ile Gln Gln 
    130                 135                 140                 
Ser Ile Asn Leu Trp Ser Leu Arg Leu Pro Ser Val Lys Ser Leu Arg 
145                 150                 155                 160 
Glu Leu Met Leu Pro His Met Arg Gln Gln Leu Asp Glu Leu Asn Val 
                165                 170                 175     
Asn Asp Pro Lys Ala Ile Ser Arg Tyr Phe Asp Arg Val Gly Ser His 
            180                 185                 190         
Phe Leu Thr Gly Ile Val Met Gly Gly Arg Ala Ile Leu Ala Ser Ser 
        195                 200                 205             
Thr Asn Lys Leu Arg Val Lys Arg Asp Tyr Ser Val Ser Val Val Ala 
    210                 215                 220                 
Lys Ala Ser Tyr Glu Gly Leu Thr Gly Gln Leu Ser Ala Glu Ala Lys 
225                 230                 235                 240 
Ala Lys Tyr Gly Glu Ser Ile Ser Ser Phe Thr Gln Tyr Ser Asn Thr 
                245                 250                 255     
His Gln Glu Val Arg Gly Gly Asp Gly Ala Lys Ala His Gly Val Phe 
            260                 265                 270         
Ser Gly Lys Lys Glu Asp Phe Gln Ala Trp Val Asp Ser Val Ser Ala 
        275                 280                 285             
Ser Pro Asp Phe Val Asp Phe Val Pro Thr Ile Pro Met Gln Glu Ile 
    290                 295                 300                 
Trp Thr Leu Cys Ser Ser Glu Ala Gln Ala Glu Ala Met Arg Lys His 
305                 310                 315                 320 
Tyr Asp Asp Val Trp Ala Pro Ala Gln Ser Glu Lys Tyr Arg Val Lys 
                325                 330                 335     
Ala Asn Tyr Ile Asp Gln Leu Val Val Ile Thr Gly Gly Ser Ser Thr 
            340                 345                 350         
Ile Glu Pro Pro Val Gly Tyr Ser Lys Ile Glu Tyr Asp Leu Asn Ala 
        355                 360                 365             
Gly Ala Gly Gly Asp Phe Leu Tyr Leu Cys Tyr His Glu Gln Thr Trp 
    370                 375                 380                 
Gln Ala Asp Arg Pro Lys Asp Ala Val Thr Asp Ile Arg Ile Ile Phe 
385                 390                 395                 400 
Asn Lys Glu Pro Thr Pro Pro Gly Tyr Thr Lys Leu Pro Gln Asp Leu 
                405                 410                 415     
Asn Lys Gly Ala Gly Gly Asp Asp Val Phe Leu Cys Tyr Lys Thr Glu 
            420                 425                 430         
Ala Tyr Asn Thr Asp Thr Ala Ile Asn Lys Val Thr Val Ile Gly Gly 
        435                 440                 445             
Asn Asn Ala Asp Ile Asn Ala Pro Tyr Gly Tyr Leu Lys Val Pro Gly 
    450                 455                 460                 
Asp Leu Asn Arg Gly Ala Gly Gly Asn Phe Ile Tyr Ala Cys Thr Phe 
465                 470                 475                 480 
Val Gly Lys Leu Glu His His His His His His 
                485                 490     

<210>  278
<211>  491
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  278
Met Glu Asn Ile Asp Leu Pro Gln Gly Leu Val Asn Phe Ser Thr Gln 
1               5                   10                  15      
His Leu Gln Leu Ile Arg Phe Lys Ala Gly Leu Asn Glu Thr Val Leu 
            20                  25                  30          
Pro Gly Val Glu Ala Ile Gly Leu Gly Tyr Asn Pro Phe Ile Ser Tyr 
        35                  40                  45              
Ala Ser Val Asn Ser Gly Ala Val Gln Leu Phe Asp Trp Ala Thr Ala 
    50                  55                  60                  
Lys Lys Arg Glu Val Pro Phe Lys Ala Gly Tyr Phe Val Pro Glu Leu 
65                  70                  75                  80  
Val Asp Val Gln Gln Asn Asp Ser Ala Thr Tyr Thr Asn Val Ser Gly 
                85                  90                  95      
Asn Thr Ile Ser Glu Tyr Gln Arg Ser Leu Ala Thr Ser Val Ala Ile 
            100                 105                 110         
Glu Gly Arg Tyr Asn Phe Phe Ser Gly Ser Leu Ser Thr Asp Phe Asp 
        115                 120                 125             
Ser Asn Ser Leu Arg Asn Ala Glu Asn Glu Phe Thr Arg Ile Gln Gln 
    130                 135                 140                 
Ser Ile Asn Leu Trp Ser Leu Arg Leu Pro Ser Val Lys Ser Leu Arg 
145                 150                 155                 160 
Glu Leu Met Leu Pro His Met Arg Gln Gln Leu Asp Glu Leu Asn Val 
                165                 170                 175     
Asn Asp Pro Lys Ala Ile Ser Arg Tyr Phe Asp Arg Val Gly Ser His 
            180                 185                 190         
Phe Leu Thr Gly Ile Val Met Gly Gly Arg Ala Ile Leu Ala Ser Ser 
        195                 200                 205             
Thr Asn Lys Leu Arg Val Lys Arg Asp Tyr Ser Val Ser Val Val Ala 
    210                 215                 220                 
Lys Ala Ser Tyr Glu Gly Leu Thr Gly Gln Leu Ser Ala Glu Ala Lys 
225                 230                 235                 240 
Ala Lys Tyr Gly Glu Ser Ile Ser Ser Phe Thr Gln Tyr Ser Asn Thr 
                245                 250                 255     
His Gln Glu Val Arg Gly Gly Asp Gly Ala Lys Ala His Gly Val Phe 
            260                 265                 270         
Ser Gly Lys Lys Glu Asp Phe Gln Ala Trp Val Asp Ser Val Ser Ala 
        275                 280                 285             
Ser Pro Asp Phe Val Asp Phe Val Pro Thr Ile Pro Met Gln Glu Ile 
    290                 295                 300                 
Trp Thr Leu Cys Ser Ser Glu Ala Gln Ala Glu Ala Met Arg Lys His 
305                 310                 315                 320 
Tyr Asp Asp Val Trp Ala Pro Ala Gln Ser Glu Lys Tyr Arg Val Lys 
                325                 330                 335     
Ala Asn Tyr Ile Asp Gln Leu Val Val Ile Thr Gly Gly Ser Ser Thr 
            340                 345                 350         
Ile Glu Pro Pro Val Gly Tyr Ser Lys Ile Glu Tyr Asp Leu Asn Ala 
        355                 360                 365             
Gly Ala Gly Gly Asp Phe Ile Tyr Leu Cys Tyr His Glu Gln Thr Trp 
    370                 375                 380                 
Gln Ala Asp Arg Pro Lys Asp Ala Val Thr Asp Ile Arg Ile Ile Phe 
385                 390                 395                 400 
Asn Lys Glu Pro Thr Pro Pro Gly Tyr Thr Lys Leu Pro Gln Asp Leu 
                405                 410                 415     
Asn Lys Gly Ala Gly Gly Asp Asp Val Phe Leu Cys Tyr Lys Thr Glu 
            420                 425                 430         
Ala Tyr Asn Thr Asp Thr Ala Ile Asn Lys Val Thr Val Ile Gly Gly 
        435                 440                 445             
Asn Asn Ala Asp Ile Asn Ala Pro Tyr Gly Tyr Leu Lys Val Pro Gly 
    450                 455                 460                 
Asp Leu Asn Arg Gly Ala Gly Gly Asn Phe Ile Tyr Ala Cys Thr Phe 
465                 470                 475                 480 
Val Gly Lys Leu Glu His His His His His His 
                485                 490     

<210>  279
<211>  483
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  279
Met Glu Asn Ile Asp Leu Pro Gln Gly Leu Val Asn Phe Ser Thr Gln 
1               5                   10                  15      
His Leu Gln Leu Ile Arg Phe Lys Ala Gly Leu Asn Glu Thr Val Leu 
            20                  25                  30          
Pro Gly Val Glu Ala Ile Gly Leu Gly Tyr Asn Pro Phe Ile Ser Tyr 
        35                  40                  45              
Ala Ser Val Asn Ser Gly Ala Val Gln Leu Phe Asp Trp Ala Thr Ala 
    50                  55                  60                  
Lys Lys Arg Glu Val Pro Phe Lys Ala Gly Tyr Phe Val Pro Glu Leu 
65                  70                  75                  80  
Val Asp Val Gln Gln Asn Asp Ser Ala Thr Tyr Thr Asn Val Ser Gly 
                85                  90                  95      
Asn Thr Ile Ser Glu Tyr Gln Arg Ser Leu Ala Thr Ser Val Ala Ile 
            100                 105                 110         
Glu Gly Arg Tyr Asn Phe Phe Ser Gly Ser Leu Ser Thr Asp Phe Asp 
        115                 120                 125             
Ser Asn Ser Leu Arg Asn Ala Glu Asn Glu Phe Thr Arg Ile Gln Gln 
    130                 135                 140                 
Ser Ile Asn Leu Trp Ser Leu Arg Leu Pro Ser Val Lys Ser Leu Arg 
145                 150                 155                 160 
Glu Leu Met Leu Pro His Met Arg Gln Gln Leu Asp Glu Leu Asn Val 
                165                 170                 175     
Asn Asp Pro Lys Ala Ile Ser Arg Tyr Phe Asp Arg Val Gly Ser His 
            180                 185                 190         
Phe Leu Thr Gly Ile Val Met Gly Gly Arg Ala Ile Leu Ala Ser Ser 
        195                 200                 205             
Thr Asn Lys Leu Arg Val Lys Arg Asp Tyr Ser Val Ser Val Val Ala 
    210                 215                 220                 
Lys Ala Ser Tyr Glu Gly Leu Thr Gly Gln Leu Ser Ala Glu Ala Lys 
225                 230                 235                 240 
Ala Lys Tyr Gly Glu Ser Ile Ser Ser Phe Thr Gln Tyr Ser Asn Thr 
                245                 250                 255     
His Gln Glu Val Arg Gly Gly Asp Gly Ala Lys Ala His Gly Val Phe 
            260                 265                 270         
Ser Gly Lys Lys Glu Asp Phe Gln Ala Trp Val Asp Ser Val Ser Ala 
        275                 280                 285             
Ser Pro Asp Phe Val Asp Phe Val Pro Thr Ile Pro Met Gln Glu Ile 
    290                 295                 300                 
Trp Thr Leu Cys Ser Ser Glu Ala Gln Ala Glu Ala Met Arg Lys His 
305                 310                 315                 320 
Phe Asp Asp Val Trp Ala Pro Ala Gln Ser Glu Lys Phe Arg Val Lys 
                325                 330                 335     
Ala Asn Tyr Ile Asp Gln Leu Val Val Ile Thr Gly Gly Ser Ser Thr 
            340                 345                 350         
Ile Glu Pro Pro Val Gly Tyr Ser Lys Ile Glu Tyr Asp Leu Asn Ala 
        355                 360                 365             
Gly Ala Gly Gly Asp Phe Ile Tyr Leu Cys Tyr His Glu Gln Thr Trp 
    370                 375                 380                 
Gln Ala Asp Arg Pro Lys Asp Ala Val Thr Asp Ile Arg Ile Ile Phe 
385                 390                 395                 400 
Asn Lys Glu Pro Thr Pro Pro Gly Tyr Thr Lys Leu Pro Gln Asp Leu 
                405                 410                 415     
Asn Lys Gly Ala Gly Gly Asp Asp Val Phe Leu Cys Tyr Lys Thr Glu 
            420                 425                 430         
Ala Phe Asn Thr Asp Thr Ala Ile Asn Lys Val Thr Val Leu Gly Gly 
        435                 440                 445             
Asn Asn Ala Asp Leu Asn Ala Pro Tyr Gly Tyr Leu Lys Val Pro Gly 
    450                 455                 460                 
Asp Leu Asn Arg Gly Ala Gly Gly Asn Phe Ile Tyr Ala Cys Thr Phe 
465                 470                 475                 480 
Val Gly Lys 
            

<210>  280
<211>  483
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  280
Met Glu Asn Ile Asp Leu Pro Gln Gly Leu Val Asn Phe Ser Thr Gln 
1               5                   10                  15      
His Leu Gln Leu Ile Arg Phe Lys Ala Gly Leu Asn Glu Thr Val Leu 
            20                  25                  30          
Pro Gly Val Glu Ala Ile Gly Leu Gly Tyr Asn Pro Phe Ile Ser Tyr 
        35                  40                  45              
Ala Ser Val Asn Ser Gly Ala Val Gln Leu Phe Asp Trp Ala Thr Ala 
    50                  55                  60                  
Lys Lys Arg Glu Val Pro Phe Lys Ala Gly Tyr Phe Val Pro Glu Leu 
65                  70                  75                  80  
Val Asp Val Gln Gln Asn Asp Ser Ala Thr Tyr Thr Asn Val Ser Gly 
                85                  90                  95      
Asn Thr Leu Ser Glu Tyr Gln Arg Ser Leu Ala Thr Ser Val Ala Ile 
            100                 105                 110         
Glu Gly Arg Tyr Asn Phe Phe Ser Gly Ser Leu Ser Thr Asp Phe Asp 
        115                 120                 125             
Ser Asn Ser Leu Arg Asn Ala Glu Asn Glu Phe Thr Arg Ile Gln Gln 
    130                 135                 140                 
Ser Ile Asn Leu Trp Ser Leu Arg Leu Pro Ser Val Lys Ser Leu Arg 
145                 150                 155                 160 
Glu Leu Met Leu Pro His Met Arg Gln Gln Leu Asp Glu Leu Asn Val 
                165                 170                 175     
Asn Asp Pro Lys Ala Ile Ser Arg Tyr Phe Asp Arg Val Gly Ser His 
            180                 185                 190         
Phe Leu Thr Gly Ile Val Met Gly Gly Arg Ala Ile Leu Ala Ser Ser 
        195                 200                 205             
Thr Asn Lys Leu Arg Val Lys Arg Asp Tyr Ser Val Ser Val Val Ala 
    210                 215                 220                 
Lys Ala Ser Tyr Glu Gly Leu Thr Gly Gln Leu Ser Ala Glu Ala Lys 
225                 230                 235                 240 
Ala Lys Tyr Gly Glu Ser Ile Ser Ser Phe Thr Gln Tyr Ser Asn Thr 
                245                 250                 255     
His Gln Glu Val Arg Gly Gly Asp Gly Ala Lys Ala His Gly Val Phe 
            260                 265                 270         
Ser Gly Lys Lys Glu Asp Phe Gln Ala Trp Val Asp Ser Val Ser Ala 
        275                 280                 285             
Ser Pro Asp Phe Val Asp Phe Val Pro Thr Ile Pro Met Gln Glu Ile 
    290                 295                 300                 
Trp Thr Leu Cys Ser Ser Glu Ala Gln Ala Glu Ala Met Arg Lys His 
305                 310                 315                 320 
Phe Asp Asp Val Trp Ala Pro Ala Gln Ser Glu Lys Phe Arg Val Lys 
                325                 330                 335     
Ala Asn Tyr Ile Asp Gln Leu Val Val Ile Thr Gly Gly Ser Ser Thr 
            340                 345                 350         
Leu Glu Pro Pro Val Gly Tyr Ser Lys Ile Glu Tyr Asp Leu Asn Ala 
        355                 360                 365             
Gly Ala Gly Gly Asp Phe Ile Tyr Leu Cys Tyr His Glu Gln Thr Trp 
    370                 375                 380                 
Gln Ala Asp Arg Pro Lys Asp Ala Val Thr Asp Ile Arg Ile Ile Phe 
385                 390                 395                 400 
Asn Lys Glu Pro Thr Pro Pro Gly Tyr Thr Lys Leu Pro Gln Asp Leu 
                405                 410                 415     
Asn Lys Gly Ala Gly Gly Asp Asp Val Phe Leu Cys Tyr Lys Thr Glu 
            420                 425                 430         
Ala Phe Asn Thr Asp Thr Ala Ile Asn Lys Val Thr Val Ile Gly Gly 
        435                 440                 445             
Asn Asn Ala Asp Leu Asn Ala Pro Tyr Gly Tyr Leu Lys Val Pro Gly 
    450                 455                 460                 
Asp Leu Asn Arg Gly Ala Gly Gly Asn Phe Ile Tyr Ala Cys Thr Phe 
465                 470                 475                 480 
Val Gly Lys 
            

<210>  281
<211>  483
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  281
Met Glu Asn Ile Asp Leu Pro Gln Gly Leu Val Asn Phe Ser Thr Gln 
1               5                   10                  15      
His Leu Gln Leu Ile Arg Phe Lys Ala Gly Leu Asn Glu Thr Val Leu 
            20                  25                  30          
Pro Gly Val Glu Ala Ile Gly Leu Gly Tyr Asn Pro Phe Ile Ser Tyr 
        35                  40                  45              
Ala Ser Val Asn Ser Gly Ala Val Gln Leu Phe Asp Trp Ala Thr Ala 
    50                  55                  60                  
Lys Lys Arg Glu Val Pro Phe Lys Ala Gly Tyr Phe Val Pro Glu Leu 
65                  70                  75                  80  
Val Asp Val Gln Gln Asn Asp Ser Ala Thr Phe Thr Asn Val Ser Gly 
                85                  90                  95      
Asn Thr Leu Ser Glu Tyr Gln Arg Ser Leu Ala Thr Ser Val Ala Ile 
            100                 105                 110         
Glu Gly Arg Tyr Asn Phe Phe Ser Gly Ser Leu Ser Thr Asp Phe Asp 
        115                 120                 125             
Ser Asn Ser Leu Arg Asn Ala Glu Asn Glu Phe Thr Arg Ile Gln Gln 
    130                 135                 140                 
Ser Ile Asn Leu Trp Ser Leu Arg Leu Pro Ser Val Lys Ser Leu Arg 
145                 150                 155                 160 
Glu Leu Met Leu Pro His Met Arg Gln Gln Leu Asp Glu Leu Asn Val 
                165                 170                 175     
Asn Asp Pro Lys Ala Ile Ser Arg Tyr Phe Asp Arg Val Gly Ser His 
            180                 185                 190         
Phe Leu Thr Gly Ile Val Met Gly Gly Arg Ala Ile Leu Ala Ser Ser 
        195                 200                 205             
Thr Asn Lys Leu Arg Val Lys Arg Asp Tyr Ser Val Ser Val Val Ala 
    210                 215                 220                 
Lys Ala Ser Tyr Glu Gly Leu Thr Gly Gln Leu Ser Ala Glu Ala Lys 
225                 230                 235                 240 
Ala Lys Tyr Gly Glu Ser Ile Ser Ser Phe Thr Gln Tyr Ser Asn Thr 
                245                 250                 255     
His Gln Glu Val Arg Gly Gly Asp Gly Ala Lys Ala His Gly Val Phe 
            260                 265                 270         
Ser Gly Lys Lys Glu Asp Phe Gln Ala Trp Val Asp Ser Val Ser Ala 
        275                 280                 285             
Ser Pro Asp Phe Val Asp Phe Val Pro Thr Ile Pro Met Gln Glu Ile 
    290                 295                 300                 
Trp Thr Leu Cys Ser Ser Glu Ala Gln Ala Glu Ala Met Arg Lys His 
305                 310                 315                 320 
Tyr Asp Asp Val Trp Ala Pro Ala Gln Ser Glu Lys Tyr Arg Val Lys 
                325                 330                 335     
Ala Asn Tyr Ile Asp Gln Leu Val Val Ile Thr Gly Gly Ser Ser Thr 
            340                 345                 350         
Leu Glu Pro Pro Val Gly Tyr Ser Lys Ile Glu Tyr Asp Leu Asn Ala 
        355                 360                 365             
Gly Ala Gly Gly Asp Phe Ile Tyr Leu Cys Tyr His Glu Gln Thr Trp 
    370                 375                 380                 
Gln Ala Asp Arg Pro Lys Asp Ala Val Thr Asp Ile Arg Ile Ile Phe 
385                 390                 395                 400 
Asn Lys Glu Pro Thr Pro Pro Gly Tyr Thr Lys Leu Pro Gln Asp Leu 
                405                 410                 415     
Asn Lys Gly Ala Gly Gly Asp Asp Val Phe Leu Cys Tyr Lys Thr Glu 
            420                 425                 430         
Ala Tyr Asn Thr Asp Thr Ala Leu Asn Lys Val Thr Val Ile Gly Gly 
        435                 440                 445             
Asn Asn Ala Asp Ile Asn Ala Pro Phe Gly Tyr Leu Lys Val Pro Gly 
    450                 455                 460                 
Asp Leu Asn Arg Gly Ala Gly Gly Asn Phe Ile Tyr Ala Cys Thr Phe 
465                 470                 475                 480 
Val Gly Lys 
            

<210>  282
<211>  483
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  282
Met Glu Asn Ile Asp Leu Pro Gln Gly Leu Val Asn Phe Ser Thr Gln 
1               5                   10                  15      
His Leu Gln Leu Ile Arg Phe Lys Ala Gly Leu Asn Glu Thr Val Leu 
            20                  25                  30          
Pro Gly Val Glu Ala Ile Gly Leu Gly Tyr Asn Pro Phe Ile Ser Tyr 
        35                  40                  45              
Ala Ser Val Asn Ser Gly Ala Val Gln Leu Phe Asp Trp Ala Thr Ala 
    50                  55                  60                  
Lys Lys Arg Glu Val Pro Phe Lys Ala Gly Tyr Phe Val Pro Glu Leu 
65                  70                  75                  80  
Val Asp Val Gln Gln Asn Asp Ser Ala Thr Tyr Thr Asn Val Ser Gly 
                85                  90                  95      
Asn Thr Ile Ser Glu Tyr Gln Arg Ser Leu Ala Thr Ser Val Ala Ile 
            100                 105                 110         
Glu Gly Arg Tyr Asn Phe Phe Ser Gly Ser Leu Ser Thr Asp Phe Asp 
        115                 120                 125             
Ser Asn Ser Leu Arg Asn Ala Glu Asn Glu Phe Thr Arg Ile Gln Gln 
    130                 135                 140                 
Ser Ile Asn Leu Trp Ser Leu Arg Leu Pro Ser Val Lys Ser Leu Arg 
145                 150                 155                 160 
Glu Leu Met Leu Pro His Met Arg Gln Gln Leu Asp Glu Leu Asn Val 
                165                 170                 175     
Asn Asp Pro Lys Ala Ile Ser Arg Tyr Phe Asp Arg Val Gly Ser His 
            180                 185                 190         
Phe Leu Thr Gly Ile Val Met Gly Gly Arg Ala Ile Leu Ala Ser Ser 
        195                 200                 205             
Thr Asn Lys Leu Arg Val Lys Arg Asp Tyr Ser Val Ser Val Val Ala 
    210                 215                 220                 
Lys Ala Ser Tyr Glu Gly Leu Thr Gly Gln Leu Ser Ala Glu Ala Lys 
225                 230                 235                 240 
Ala Lys Tyr Gly Glu Ser Ile Ser Ser Phe Thr Gln Tyr Ser Asn Thr 
                245                 250                 255     
His Gln Glu Val Arg Gly Gly Asp Gly Ala Lys Ala His Gly Val Phe 
            260                 265                 270         
Ser Gly Lys Lys Glu Asp Phe Gln Ala Trp Val Asp Ser Val Ser Ala 
        275                 280                 285             
Ser Pro Asp Phe Val Asp Phe Val Pro Thr Ile Pro Met Gln Glu Ile 
    290                 295                 300                 
Trp Thr Leu Cys Ser Ser Glu Ala Gln Ala Glu Ala Met Arg Lys His 
305                 310                 315                 320 
Tyr Asp Asp Val Trp Ala Pro Ala Gln Ser Glu Lys Phe Arg Val Lys 
                325                 330                 335     
Ala Asn Tyr Leu Asp Gln Leu Val Val Ile Thr Gly Gly Ser Ser Thr 
            340                 345                 350         
Ile Glu Pro Pro Val Gly Tyr Ser Lys Ile Glu Tyr Asp Leu Asn Ala 
        355                 360                 365             
Gly Ala Gly Gly Asp Phe Ile Tyr Leu Cys Tyr His Glu Gln Thr Trp 
    370                 375                 380                 
Gln Ala Asp Arg Pro Lys Asp Ala Val Thr Asp Ile Arg Ile Ile Phe 
385                 390                 395                 400 
Asn Lys Glu Pro Thr Pro Pro Gly Tyr Thr Lys Leu Pro Gln Asp Leu 
                405                 410                 415     
Asn Lys Gly Ala Gly Gly Asp Asp Val Phe Leu Cys Tyr Lys Thr Glu 
            420                 425                 430         
Ala Tyr Asn Thr Asp Thr Ala Ile Asn Lys Val Thr Val Leu Gly Gly 
        435                 440                 445             
Asn Asn Ala Asp Ile Asn Ala Pro Phe Gly Tyr Leu Lys Val Pro Gly 
    450                 455                 460                 
Asp Leu Asn Arg Gly Ala Gly Gly Asn Phe Ile Tyr Ala Cys Thr Phe 
465                 470                 475                 480 
Val Gly Lys 
            

<210>  283
<211>  483
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  283
Met Glu Asn Ile Asp Leu Pro Gln Gly Leu Val Asn Phe Ser Thr Gln 
1               5                   10                  15      
His Leu Gln Leu Ile Arg Phe Lys Ala Gly Leu Asn Glu Thr Val Leu 
            20                  25                  30          
Pro Gly Val Glu Ala Ile Gly Leu Gly Tyr Asn Pro Phe Ile Ser Tyr 
        35                  40                  45              
Ala Ser Val Asn Ser Gly Ala Val Gln Leu Phe Asp Trp Ala Thr Ala 
    50                  55                  60                  
Lys Lys Arg Glu Val Pro Phe Lys Ala Gly Tyr Phe Val Pro Glu Leu 
65                  70                  75                  80  
Val Asp Val Gln Gln Asn Asp Ser Ala Thr Tyr Thr Asn Val Ser Gly 
                85                  90                  95      
Asn Thr Leu Ser Glu Tyr Gln Arg Ser Leu Ala Thr Ser Val Ala Ile 
            100                 105                 110         
Glu Gly Arg Tyr Asn Phe Phe Ser Gly Ser Leu Ser Thr Asp Phe Asp 
        115                 120                 125             
Ser Asn Ser Leu Arg Asn Ala Glu Asn Glu Phe Thr Arg Ile Gln Gln 
    130                 135                 140                 
Ser Ile Asn Leu Trp Ser Leu Arg Leu Pro Ser Val Lys Ser Leu Arg 
145                 150                 155                 160 
Glu Leu Met Leu Pro His Met Arg Gln Gln Leu Asp Glu Leu Asn Val 
                165                 170                 175     
Asn Asp Pro Lys Ala Ile Ser Arg Tyr Phe Asp Arg Val Gly Ser His 
            180                 185                 190         
Phe Leu Thr Gly Ile Val Met Gly Gly Arg Ala Ile Leu Ala Ser Ser 
        195                 200                 205             
Thr Asn Lys Leu Arg Val Lys Arg Asp Tyr Ser Val Ser Val Val Ala 
    210                 215                 220                 
Lys Ala Ser Tyr Glu Gly Leu Thr Gly Gln Leu Ser Ala Glu Ala Lys 
225                 230                 235                 240 
Ala Lys Tyr Gly Glu Ser Ile Ser Ser Phe Thr Gln Tyr Ser Asn Thr 
                245                 250                 255     
His Gln Glu Val Arg Gly Gly Asp Gly Ala Lys Ala His Gly Val Phe 
            260                 265                 270         
Ser Gly Lys Lys Glu Asp Phe Gln Ala Trp Val Asp Ser Val Ser Ala 
        275                 280                 285             
Ser Pro Asp Phe Val Asp Phe Val Pro Thr Ile Pro Met Gln Glu Ile 
    290                 295                 300                 
Trp Thr Leu Cys Ser Ser Glu Ala Gln Ala Glu Ala Met Arg Lys His 
305                 310                 315                 320 
Tyr Asp Asp Val Trp Ala Pro Ala Gln Ser Glu Lys Phe Arg Val Lys 
                325                 330                 335     
Ala Asn Tyr Ile Asp Gln Leu Val Val Ile Thr Gly Gly Ser Ser Thr 
            340                 345                 350         
Ile Glu Pro Pro Val Gly Tyr Ser Lys Ile Glu Tyr Asp Leu Asn Ala 
        355                 360                 365             
Gly Ala Gly Gly Asp Phe Ile Tyr Leu Cys Tyr His Glu Gln Thr Trp 
    370                 375                 380                 
Gln Ala Asp Arg Pro Lys Asp Ala Val Thr Asp Ile Arg Ile Ile Phe 
385                 390                 395                 400 
Asn Lys Glu Pro Thr Pro Pro Gly Tyr Thr Lys Leu Pro Gln Asp Leu 
                405                 410                 415     
Asn Lys Gly Ala Gly Gly Asp Asp Val Phe Leu Cys Tyr Lys Thr Glu 
            420                 425                 430         
Ala Phe Asn Thr Asp Thr Ala Ile Asn Lys Val Thr Val Ile Gly Gly 
        435                 440                 445             
Asn Asn Ala Asp Ile Asn Ala Pro Tyr Gly Tyr Leu Lys Val Pro Gly 
    450                 455                 460                 
Asp Leu Asn Arg Gly Ala Gly Gly Asn Phe Ile Tyr Ala Cys Thr Phe 
465                 470                 475                 480 
Val Gly Lys 
            

<210>  284
<211>  483
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  284
Met Glu Asn Ile Asp Leu Pro Gln Gly Leu Val Asn Phe Ser Thr Gln 
1               5                   10                  15      
His Leu Gln Leu Ile Arg Phe Lys Ala Gly Leu Asn Glu Thr Val Leu 
            20                  25                  30          
Pro Gly Val Glu Ala Ile Gly Leu Gly Tyr Asn Pro Phe Ile Ser Tyr 
        35                  40                  45              
Ala Ser Val Asn Ser Gly Ala Val Gln Leu Phe Asp Trp Ala Thr Ala 
    50                  55                  60                  
Lys Lys Arg Glu Val Pro Phe Lys Ala Gly Tyr Phe Val Pro Glu Leu 
65                  70                  75                  80  
Val Asp Val Gln Gln Asn Asp Ser Ala Thr Phe Thr Asn Val Ser Gly 
                85                  90                  95      
Asn Thr Ile Ser Glu Tyr Gln Arg Ser Leu Ala Thr Ser Val Ala Ile 
            100                 105                 110         
Glu Gly Arg Tyr Asn Phe Phe Ser Gly Ser Leu Ser Thr Asp Phe Asp 
        115                 120                 125             
Ser Asn Ser Leu Arg Asn Ala Glu Asn Glu Phe Thr Arg Ile Gln Gln 
    130                 135                 140                 
Ser Ile Asn Leu Trp Ser Leu Arg Leu Pro Ser Val Lys Ser Leu Arg 
145                 150                 155                 160 
Glu Leu Met Leu Pro His Met Arg Gln Gln Leu Asp Glu Leu Asn Val 
                165                 170                 175     
Asn Asp Pro Lys Ala Ile Ser Arg Tyr Phe Asp Arg Val Gly Ser His 
            180                 185                 190         
Phe Leu Thr Gly Ile Val Met Gly Gly Arg Ala Ile Leu Ala Ser Ser 
        195                 200                 205             
Thr Asn Lys Leu Arg Val Lys Arg Asp Tyr Ser Val Ser Val Val Ala 
    210                 215                 220                 
Lys Ala Ser Tyr Glu Gly Leu Thr Gly Gln Leu Ser Ala Glu Ala Lys 
225                 230                 235                 240 
Ala Lys Tyr Gly Glu Ser Ile Ser Ser Phe Thr Gln Tyr Ser Asn Thr 
                245                 250                 255     
His Gln Glu Val Arg Gly Gly Asp Gly Ala Lys Ala His Gly Val Phe 
            260                 265                 270         
Ser Gly Lys Lys Glu Asp Phe Gln Ala Trp Val Asp Ser Val Ser Ala 
        275                 280                 285             
Ser Pro Asp Phe Val Asp Phe Val Pro Thr Ile Pro Met Gln Glu Ile 
    290                 295                 300                 
Trp Thr Leu Cys Ser Ser Glu Ala Gln Ala Glu Ala Met Arg Lys His 
305                 310                 315                 320 
Tyr Asp Asp Val Trp Ala Pro Ala Gln Ser Glu Lys Tyr Arg Val Lys 
                325                 330                 335     
Ala Asn Phe Ile Asp Gln Leu Val Val Ile Thr Gly Gly Ser Ser Thr 
            340                 345                 350         
Leu Glu Pro Pro Val Gly Tyr Ser Lys Ile Glu Tyr Asp Leu Asn Ala 
        355                 360                 365             
Gly Ala Gly Gly Asp Phe Ile Tyr Leu Cys Tyr His Glu Gln Thr Trp 
    370                 375                 380                 
Gln Ala Asp Arg Pro Lys Asp Ala Val Thr Asp Ile Arg Ile Ile Phe 
385                 390                 395                 400 
Asn Lys Glu Pro Thr Pro Pro Gly Tyr Thr Lys Leu Pro Gln Asp Leu 
                405                 410                 415     
Asn Lys Gly Ala Gly Gly Asp Asp Val Phe Leu Cys Tyr Lys Thr Glu 
            420                 425                 430         
Ala Tyr Asn Thr Asp Thr Ala Leu Asn Lys Val Thr Val Ile Gly Gly 
        435                 440                 445             
Asn Asn Ala Asp Ile Asn Ala Pro Tyr Gly Tyr Leu Lys Val Pro Gly 
    450                 455                 460                 
Asp Leu Asn Arg Gly Ala Gly Gly Asn Phe Ile Tyr Ala Cys Thr Phe 
465                 470                 475                 480 
Val Gly Lys 
            

<210>  285
<211>  483
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  285
Met Glu Asn Ile Asp Leu Pro Gln Gly Leu Val Asn Phe Ser Thr Gln 
1               5                   10                  15      
His Leu Gln Leu Ile Arg Phe Lys Ala Gly Leu Asn Glu Thr Val Leu 
            20                  25                  30          
Pro Gly Val Glu Ala Ile Gly Leu Gly Tyr Asn Pro Phe Ile Ser Tyr 
        35                  40                  45              
Ala Ser Val Asn Ser Gly Ala Val Gln Leu Phe Asp Trp Ala Thr Ala 
    50                  55                  60                  
Lys Lys Arg Glu Val Pro Phe Lys Ala Gly Tyr Phe Val Pro Glu Leu 
65                  70                  75                  80  
Val Asp Val Gln Gln Asn Asp Ser Ala Thr Phe Thr Asn Val Ser Gly 
                85                  90                  95      
Asn Thr Ile Ser Glu Tyr Gln Arg Ser Leu Ala Thr Ser Val Ala Ile 
            100                 105                 110         
Glu Gly Arg Tyr Asn Phe Phe Ser Gly Ser Leu Ser Thr Asp Phe Asp 
        115                 120                 125             
Ser Asn Ser Leu Arg Asn Ala Glu Asn Glu Phe Thr Arg Ile Gln Gln 
    130                 135                 140                 
Ser Ile Asn Leu Trp Ser Leu Arg Leu Pro Ser Val Lys Ser Leu Arg 
145                 150                 155                 160 
Glu Leu Met Leu Pro His Met Arg Gln Gln Leu Asp Glu Leu Asn Val 
                165                 170                 175     
Asn Asp Pro Lys Ala Ile Ser Arg Tyr Phe Asp Arg Val Gly Ser His 
            180                 185                 190         
Phe Leu Thr Gly Ile Val Met Gly Gly Arg Ala Ile Leu Ala Ser Ser 
        195                 200                 205             
Thr Asn Lys Leu Arg Val Lys Arg Asp Tyr Ser Val Ser Val Val Ala 
    210                 215                 220                 
Lys Ala Ser Tyr Glu Gly Leu Thr Gly Gln Leu Ser Ala Glu Ala Lys 
225                 230                 235                 240 
Ala Lys Tyr Gly Glu Ser Ile Ser Ser Phe Thr Gln Tyr Ser Asn Thr 
                245                 250                 255     
His Gln Glu Val Arg Gly Gly Asp Gly Ala Lys Ala His Gly Val Phe 
            260                 265                 270         
Ser Gly Lys Lys Glu Asp Phe Gln Ala Trp Val Asp Ser Val Ser Ala 
        275                 280                 285             
Ser Pro Asp Phe Val Asp Phe Val Pro Thr Ile Pro Met Gln Glu Ile 
    290                 295                 300                 
Trp Thr Leu Cys Ser Ser Glu Ala Gln Ala Glu Ala Met Arg Lys His 
305                 310                 315                 320 
Phe Asp Asp Val Trp Ala Pro Ala Gln Ser Glu Lys Phe Arg Val Lys 
                325                 330                 335     
Ala Asn Tyr Leu Asp Gln Leu Val Val Leu Thr Gly Gly Ser Ser Thr 
            340                 345                 350         
Ile Glu Pro Pro Val Gly Tyr Ser Lys Leu Glu Tyr Asp Leu Asn Ala 
        355                 360                 365             
Gly Ala Gly Gly Asp Phe Ile Tyr Leu Cys Tyr His Glu Gln Thr Trp 
    370                 375                 380                 
Gln Ala Asp Arg Pro Lys Asp Ala Val Thr Asp Ile Arg Ile Ile Phe 
385                 390                 395                 400 
Asn Lys Glu Pro Thr Pro Pro Gly Tyr Thr Lys Leu Pro Gln Asp Leu 
                405                 410                 415     
Asn Lys Gly Ala Gly Gly Asp Asp Val Phe Leu Cys Tyr Lys Thr Glu 
            420                 425                 430         
Ala Phe Asn Thr Asp Thr Ala Leu Asn Lys Val Thr Val Ile Gly Gly 
        435                 440                 445             
Asn Asn Ala Asp Ile Asn Ala Pro Tyr Gly Tyr Leu Lys Val Pro Gly 
    450                 455                 460                 
Asp Leu Asn Arg Gly Ala Gly Gly Asn Phe Ile Tyr Ala Cys Thr Phe 
465                 470                 475                 480 
Val Gly Lys 
            

<210>  286
<211>  483
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  286
Met Glu Asn Ile Asp Leu Pro Gln Gly Leu Val Asn Phe Ser Thr Gln 
1               5                   10                  15      
His Leu Gln Leu Ile Arg Phe Lys Ala Gly Leu Asn Glu Thr Val Leu 
            20                  25                  30          
Pro Gly Val Glu Ala Ile Gly Leu Gly Tyr Asn Pro Phe Ile Ser Tyr 
        35                  40                  45              
Ala Ser Val Asn Ser Gly Ala Val Gln Leu Phe Asp Trp Ala Thr Ala 
    50                  55                  60                  
Lys Lys Arg Glu Val Pro Phe Lys Ala Gly Tyr Phe Val Pro Glu Leu 
65                  70                  75                  80  
Val Asp Val Gln Gln Asn Asp Ser Ala Thr Tyr Thr Asn Val Ser Gly 
                85                  90                  95      
Asn Thr Ile Ser Glu Tyr Gln Arg Ser Leu Ala Thr Ser Val Ala Ile 
            100                 105                 110         
Glu Gly Arg Tyr Asn Phe Phe Ser Gly Ser Leu Ser Thr Asp Phe Asp 
        115                 120                 125             
Ser Asn Ser Leu Arg Asn Ala Glu Asn Glu Phe Thr Arg Ile Gln Gln 
    130                 135                 140                 
Ser Ile Asn Leu Trp Ser Leu Arg Leu Pro Ser Val Lys Ser Leu Arg 
145                 150                 155                 160 
Glu Leu Met Leu Pro His Met Arg Gln Gln Leu Asp Glu Leu Asn Val 
                165                 170                 175     
Asn Asp Pro Lys Ala Ile Ser Arg Tyr Phe Asp Arg Val Gly Ser His 
            180                 185                 190         
Phe Leu Thr Gly Ile Val Met Gly Gly Arg Ala Ile Leu Ala Ser Ser 
        195                 200                 205             
Thr Asn Lys Leu Arg Val Lys Arg Asp Tyr Ser Val Ser Val Val Ala 
    210                 215                 220                 
Lys Ala Ser Tyr Glu Gly Leu Thr Gly Gln Leu Ser Ala Glu Ala Lys 
225                 230                 235                 240 
Ala Lys Tyr Gly Glu Ser Ile Ser Ser Phe Thr Gln Tyr Ser Asn Thr 
                245                 250                 255     
His Gln Glu Val Arg Gly Gly Asp Gly Ala Lys Ala His Gly Val Phe 
            260                 265                 270         
Ser Gly Lys Lys Glu Asp Phe Gln Ala Trp Val Asp Ser Val Ser Ala 
        275                 280                 285             
Ser Pro Asp Phe Val Asp Phe Val Pro Thr Ile Pro Met Gln Glu Ile 
    290                 295                 300                 
Trp Thr Leu Cys Ser Ser Glu Ala Gln Ala Glu Ala Met Arg Lys His 
305                 310                 315                 320 
Tyr Asp Asp Val Trp Ala Pro Ala Gln Ser Glu Lys Phe Arg Val Lys 
                325                 330                 335     
Ala Asn Tyr Ile Asp Gln Leu Val Val Ile Thr Gly Gly Ser Ser Thr 
            340                 345                 350         
Ile Glu Pro Pro Val Gly Tyr Ser Lys Ile Glu Tyr Asp Leu Asn Ala 
        355                 360                 365             
Gly Ala Gly Gly Asp Phe Ile Tyr Leu Cys Tyr His Glu Gln Thr Trp 
    370                 375                 380                 
Gln Ala Asp Arg Pro Lys Asp Ala Val Thr Asp Ile Arg Ile Ile Phe 
385                 390                 395                 400 
Asn Lys Glu Pro Thr Pro Pro Gly Tyr Thr Lys Leu Pro Gln Asp Leu 
                405                 410                 415     
Asn Lys Gly Ala Gly Gly Asp Asp Val Phe Leu Cys Tyr Lys Thr Glu 
            420                 425                 430         
Ala Phe Asn Thr Asp Thr Ala Ile Asn Lys Val Thr Val Ile Gly Gly 
        435                 440                 445             
Asn Asn Ala Asp Ile Asn Ala Pro Tyr Gly Tyr Leu Lys Val Pro Gly 
    450                 455                 460                 
Asp Leu Asn Arg Gly Ala Gly Gly Asn Phe Ile Tyr Ala Cys Thr Phe 
465                 470                 475                 480 
Val Gly Lys 
            

<210>  287
<211>  483
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  287
Met Glu Asn Ile Asp Leu Pro Gln Gly Leu Val Asn Phe Ser Thr Gln 
1               5                   10                  15      
His Leu Gln Leu Ile Arg Phe Lys Ala Gly Leu Asn Glu Thr Val Leu 
            20                  25                  30          
Pro Gly Val Glu Ala Ile Gly Leu Gly Tyr Asn Pro Phe Ile Ser Tyr 
        35                  40                  45              
Ala Ser Val Asn Ser Gly Ala Val Gln Leu Phe Asp Trp Ala Thr Ala 
    50                  55                  60                  
Lys Lys Arg Glu Val Pro Phe Lys Ala Gly Tyr Phe Val Pro Glu Leu 
65                  70                  75                  80  
Val Asp Val Gln Gln Asn Asp Ser Ala Thr Tyr Thr Asn Val Ser Gly 
                85                  90                  95      
Asn Thr Leu Ser Glu Tyr Gln Arg Ser Leu Ala Thr Ser Val Ala Ile 
            100                 105                 110         
Glu Gly Arg Tyr Asn Phe Phe Ser Gly Ser Leu Ser Thr Asp Phe Asp 
        115                 120                 125             
Ser Asn Ser Leu Arg Asn Ala Glu Asn Glu Phe Thr Arg Ile Gln Gln 
    130                 135                 140                 
Ser Ile Asn Leu Trp Ser Leu Arg Leu Pro Ser Val Lys Ser Leu Arg 
145                 150                 155                 160 
Glu Leu Met Leu Pro His Met Arg Gln Gln Leu Asp Glu Leu Asn Val 
                165                 170                 175     
Asn Asp Pro Lys Ala Ile Ser Arg Tyr Phe Asp Arg Val Gly Ser His 
            180                 185                 190         
Phe Leu Thr Gly Ile Val Met Gly Gly Arg Ala Ile Leu Ala Ser Ser 
        195                 200                 205             
Thr Asn Lys Leu Arg Val Lys Arg Asp Tyr Ser Val Ser Val Val Ala 
    210                 215                 220                 
Lys Ala Ser Tyr Glu Gly Leu Thr Gly Gln Leu Ser Ala Glu Ala Lys 
225                 230                 235                 240 
Ala Lys Tyr Gly Glu Ser Ile Ser Ser Phe Thr Gln Tyr Ser Asn Thr 
                245                 250                 255     
His Gln Glu Val Arg Gly Gly Asp Gly Ala Lys Ala His Gly Val Phe 
            260                 265                 270         
Ser Gly Lys Lys Glu Asp Phe Gln Ala Trp Val Asp Ser Val Ser Ala 
        275                 280                 285             
Ser Pro Asp Phe Val Asp Phe Val Pro Thr Ile Pro Met Gln Glu Ile 
    290                 295                 300                 
Trp Thr Leu Cys Ser Ser Glu Ala Gln Ala Glu Ala Met Arg Lys His 
305                 310                 315                 320 
Tyr Asp Asp Val Trp Ala Pro Ala Gln Ser Glu Lys Tyr Arg Val Lys 
                325                 330                 335     
Ala Asn Phe Ile Asp Gln Leu Val Val Ile Thr Gly Gly Ser Ser Thr 
            340                 345                 350         
Ile Glu Pro Pro Val Gly Tyr Ser Lys Ile Glu Tyr Asp Leu Asn Ala 
        355                 360                 365             
Gly Ala Gly Gly Asp Phe Ile Tyr Leu Cys Tyr His Glu Gln Thr Trp 
    370                 375                 380                 
Gln Ala Asp Arg Pro Lys Asp Ala Val Thr Asp Ile Arg Ile Ile Phe 
385                 390                 395                 400 
Asn Lys Glu Pro Thr Pro Pro Gly Tyr Thr Lys Leu Pro Gln Asp Leu 
                405                 410                 415     
Asn Lys Gly Ala Gly Gly Asp Asp Val Phe Leu Cys Tyr Lys Thr Glu 
            420                 425                 430         
Ala Tyr Asn Thr Asp Thr Ala Ile Asn Lys Val Thr Val Ile Gly Gly 
        435                 440                 445             
Asn Asn Ala Asp Ile Asn Ala Pro Phe Gly Tyr Leu Lys Val Pro Gly 
    450                 455                 460                 
Asp Leu Asn Arg Gly Ala Gly Gly Asn Phe Ile Tyr Ala Cys Thr Phe 
465                 470                 475                 480 
Val Gly Lys 
            

<210>  288
<211>  483
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  288
Met Glu Asn Ile Asp Leu Pro Gln Gly Leu Val Asn Phe Ser Thr Gln 
1               5                   10                  15      
His Leu Gln Leu Ile Arg Phe Lys Ala Gly Leu Asn Glu Thr Val Leu 
            20                  25                  30          
Pro Gly Val Glu Ala Ile Gly Leu Gly Tyr Asn Pro Phe Ile Ser Tyr 
        35                  40                  45              
Ala Ser Val Asn Ser Gly Ala Val Gln Leu Phe Asp Trp Ala Thr Ala 
    50                  55                  60                  
Lys Lys Arg Glu Val Pro Phe Lys Ala Gly Tyr Phe Val Pro Glu Leu 
65                  70                  75                  80  
Val Asp Val Gln Gln Asn Asp Ser Ala Thr Phe Thr Asn Val Ser Gly 
                85                  90                  95      
Asn Thr Ile Ser Glu Tyr Gln Arg Ser Leu Ala Thr Ser Val Ala Ile 
            100                 105                 110         
Glu Gly Arg Tyr Asn Phe Phe Ser Gly Ser Leu Ser Thr Asp Phe Asp 
        115                 120                 125             
Ser Asn Ser Leu Arg Asn Ala Glu Asn Glu Phe Thr Arg Ile Gln Gln 
    130                 135                 140                 
Ser Ile Asn Leu Trp Ser Leu Arg Leu Pro Ser Val Lys Ser Leu Arg 
145                 150                 155                 160 
Glu Leu Met Leu Pro His Met Arg Gln Gln Leu Asp Glu Leu Asn Val 
                165                 170                 175     
Asn Asp Pro Lys Ala Ile Ser Arg Tyr Phe Asp Arg Val Gly Ser His 
            180                 185                 190         
Phe Leu Thr Gly Ile Val Met Gly Gly Arg Ala Ile Leu Ala Ser Ser 
        195                 200                 205             
Thr Asn Lys Leu Arg Val Lys Arg Asp Tyr Ser Val Ser Val Val Ala 
    210                 215                 220                 
Lys Ala Ser Tyr Glu Gly Leu Thr Gly Gln Leu Ser Ala Glu Ala Lys 
225                 230                 235                 240 
Ala Lys Tyr Gly Glu Ser Ile Ser Ser Phe Thr Gln Tyr Ser Asn Thr 
                245                 250                 255     
His Gln Glu Val Arg Gly Gly Asp Gly Ala Lys Ala His Gly Val Phe 
            260                 265                 270         
Ser Gly Lys Lys Glu Asp Phe Gln Ala Trp Val Asp Ser Val Ser Ala 
        275                 280                 285             
Ser Pro Asp Phe Val Asp Phe Val Pro Thr Ile Pro Met Gln Glu Ile 
    290                 295                 300                 
Trp Thr Leu Cys Ser Ser Glu Ala Gln Ala Glu Ala Met Arg Lys His 
305                 310                 315                 320 
Tyr Asp Asp Val Trp Ala Pro Ala Gln Ser Glu Lys Phe Arg Val Lys 
                325                 330                 335     
Ala Asn Tyr Ile Asp Gln Leu Val Val Ile Thr Gly Gly Ser Ser Thr 
            340                 345                 350         
Ile Glu Pro Pro Val Gly Tyr Ser Lys Leu Glu Tyr Asp Leu Asn Ala 
        355                 360                 365             
Gly Ala Gly Gly Asp Phe Ile Tyr Leu Cys Tyr His Glu Gln Thr Trp 
    370                 375                 380                 
Gln Ala Asp Arg Pro Lys Asp Ala Val Thr Asp Ile Arg Ile Ile Phe 
385                 390                 395                 400 
Asn Lys Glu Pro Thr Pro Pro Gly Tyr Thr Lys Leu Pro Gln Asp Leu 
                405                 410                 415     
Asn Lys Gly Ala Gly Gly Asp Asp Val Phe Leu Cys Tyr Lys Thr Glu 
            420                 425                 430         
Ala Tyr Asn Thr Asp Thr Ala Ile Asn Lys Val Thr Val Leu Gly Gly 
        435                 440                 445             
Asn Asn Ala Asp Ile Asn Ala Pro Tyr Gly Tyr Leu Lys Val Pro Gly 
    450                 455                 460                 
Asp Leu Asn Arg Gly Ala Gly Gly Asn Phe Ile Tyr Ala Cys Thr Phe 
465                 470                 475                 480 
Val Gly Lys 
            

<210>  289
<211>  483
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  289
Met Glu Asn Ile Asp Leu Pro Gln Gly Leu Val Asn Phe Ser Thr Gln 
1               5                   10                  15      
His Leu Gln Leu Ile Arg Phe Lys Ala Gly Leu Asn Glu Thr Val Leu 
            20                  25                  30          
Pro Gly Val Glu Ala Ile Gly Leu Gly Tyr Asn Pro Phe Ile Ser Tyr 
        35                  40                  45              
Ala Ser Val Asn Ser Gly Ala Val Gln Leu Phe Asp Trp Ala Thr Ala 
    50                  55                  60                  
Lys Lys Arg Glu Val Pro Phe Lys Ala Gly Tyr Phe Val Pro Glu Leu 
65                  70                  75                  80  
Val Asp Val Gln Gln Asn Asp Ser Ala Thr Tyr Thr Asn Val Ser Gly 
                85                  90                  95      
Asn Thr Ile Ser Glu Tyr Gln Arg Ser Leu Ala Thr Ser Val Ala Ile 
            100                 105                 110         
Glu Gly Arg Tyr Asn Phe Phe Ser Gly Ser Leu Ser Thr Asp Phe Asp 
        115                 120                 125             
Ser Asn Ser Leu Arg Asn Ala Glu Asn Glu Phe Thr Arg Ile Gln Gln 
    130                 135                 140                 
Ser Ile Asn Leu Trp Ser Leu Arg Leu Pro Ser Val Lys Ser Leu Arg 
145                 150                 155                 160 
Glu Leu Met Leu Pro His Met Arg Gln Gln Leu Asp Glu Leu Asn Val 
                165                 170                 175     
Asn Asp Pro Lys Ala Ile Ser Arg Tyr Phe Asp Arg Val Gly Ser His 
            180                 185                 190         
Phe Leu Thr Gly Ile Val Met Gly Gly Arg Ala Ile Leu Ala Ser Ser 
        195                 200                 205             
Thr Asn Lys Leu Arg Val Lys Arg Asp Tyr Ser Val Ser Val Val Ala 
    210                 215                 220                 
Lys Ala Ser Tyr Glu Gly Leu Thr Gly Gln Leu Ser Ala Glu Ala Lys 
225                 230                 235                 240 
Ala Lys Tyr Gly Glu Ser Ile Ser Ser Phe Thr Gln Tyr Ser Asn Thr 
                245                 250                 255     
His Gln Glu Val Arg Gly Gly Asp Gly Ala Lys Ala His Gly Val Phe 
            260                 265                 270         
Ser Gly Lys Lys Glu Asp Phe Gln Ala Trp Val Asp Ser Val Ser Ala 
        275                 280                 285             
Ser Pro Asp Phe Val Asp Phe Val Pro Thr Ile Pro Met Gln Glu Ile 
    290                 295                 300                 
Trp Thr Leu Cys Ser Ser Glu Ala Gln Ala Glu Ala Met Arg Lys His 
305                 310                 315                 320 
Tyr Asp Asp Val Trp Ala Pro Ala Gln Ser Glu Lys Phe Arg Val Lys 
                325                 330                 335     
Ala Asn Tyr Ile Asp Gln Leu Val Val Ile Thr Gly Gly Ser Ser Thr 
            340                 345                 350         
Ile Glu Pro Pro Val Gly Tyr Ser Lys Leu Glu Tyr Asp Leu Asn Ala 
        355                 360                 365             
Gly Ala Gly Gly Asp Phe Ile Tyr Leu Cys Tyr His Glu Gln Thr Trp 
    370                 375                 380                 
Gln Ala Asp Arg Pro Lys Asp Ala Val Thr Asp Ile Arg Ile Ile Phe 
385                 390                 395                 400 
Asn Lys Glu Pro Thr Pro Pro Gly Tyr Thr Lys Leu Pro Gln Asp Leu 
                405                 410                 415     
Asn Lys Gly Ala Gly Gly Asp Asp Val Phe Leu Cys Tyr Lys Thr Glu 
            420                 425                 430         
Ala Tyr Asn Thr Asp Thr Ala Ile Asn Lys Val Thr Val Ile Gly Gly 
        435                 440                 445             
Asn Asn Ala Asp Ile Asn Ala Pro Tyr Gly Tyr Leu Lys Val Pro Gly 
    450                 455                 460                 
Asp Leu Asn Arg Gly Ala Gly Gly Asn Phe Ile Tyr Ala Cys Thr Phe 
465                 470                 475                 480 
Val Gly Lys 
            

<210>  290
<211>  483
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  290
Met Glu Asn Ile Asp Leu Pro Gln Gly Leu Val Asn Phe Ser Thr Gln 
1               5                   10                  15      
His Leu Gln Leu Ile Arg Phe Lys Ala Gly Leu Asn Glu Thr Val Leu 
            20                  25                  30          
Pro Gly Val Glu Ala Ile Gly Leu Gly Tyr Asn Pro Phe Ile Ser Tyr 
        35                  40                  45              
Ala Ser Val Asn Ser Gly Ala Val Gln Leu Phe Asp Trp Ala Thr Ala 
    50                  55                  60                  
Lys Lys Arg Glu Val Pro Phe Lys Ala Gly Tyr Phe Val Pro Glu Leu 
65                  70                  75                  80  
Val Asp Val Gln Gln Asn Asp Ser Ala Thr Phe Thr Asn Val Ser Gly 
                85                  90                  95      
Asn Thr Ile Ser Glu Tyr Gln Arg Ser Leu Ala Thr Ser Val Ala Ile 
            100                 105                 110         
Glu Gly Arg Tyr Asn Phe Phe Ser Gly Ser Leu Ser Thr Asp Phe Asp 
        115                 120                 125             
Ser Asn Ser Leu Arg Asn Ala Glu Asn Glu Phe Thr Arg Ile Gln Gln 
    130                 135                 140                 
Ser Ile Asn Leu Trp Ser Leu Arg Leu Pro Ser Val Lys Ser Leu Arg 
145                 150                 155                 160 
Glu Leu Met Leu Pro His Met Arg Gln Gln Leu Asp Glu Leu Asn Val 
                165                 170                 175     
Asn Asp Pro Lys Ala Ile Ser Arg Tyr Phe Asp Arg Val Gly Ser His 
            180                 185                 190         
Phe Leu Thr Gly Ile Val Met Gly Gly Arg Ala Ile Leu Ala Ser Ser 
        195                 200                 205             
Thr Asn Lys Leu Arg Val Lys Arg Asp Tyr Ser Val Ser Val Val Ala 
    210                 215                 220                 
Lys Ala Ser Tyr Glu Gly Leu Thr Gly Gln Leu Ser Ala Glu Ala Lys 
225                 230                 235                 240 
Ala Lys Tyr Gly Glu Ser Ile Ser Ser Phe Thr Gln Tyr Ser Asn Thr 
                245                 250                 255     
His Gln Glu Val Arg Gly Gly Asp Gly Ala Lys Ala His Gly Val Phe 
            260                 265                 270         
Ser Gly Lys Lys Glu Asp Phe Gln Ala Trp Val Asp Ser Val Ser Ala 
        275                 280                 285             
Ser Pro Asp Phe Val Asp Phe Val Pro Thr Ile Pro Met Gln Glu Ile 
    290                 295                 300                 
Trp Thr Leu Cys Ser Ser Glu Ala Gln Ala Glu Ala Met Arg Lys His 
305                 310                 315                 320 
Tyr Asp Asp Val Trp Ala Pro Ala Gln Ser Glu Lys Phe Arg Val Lys 
                325                 330                 335     
Ala Asn Tyr Ile Asp Gln Leu Val Val Ile Thr Gly Gly Ser Ser Thr 
            340                 345                 350         
Ile Glu Pro Pro Val Gly Tyr Ser Lys Ile Glu Tyr Asp Leu Asn Ala 
        355                 360                 365             
Gly Ala Gly Gly Asp Phe Ile Tyr Leu Cys Tyr His Glu Gln Thr Trp 
    370                 375                 380                 
Gln Ala Asp Arg Pro Lys Asp Ala Val Thr Asp Ile Arg Ile Ile Phe 
385                 390                 395                 400 
Asn Lys Glu Pro Thr Pro Pro Gly Tyr Thr Lys Leu Pro Gln Asp Leu 
                405                 410                 415     
Asn Lys Gly Ala Gly Gly Asp Asp Val Phe Leu Cys Tyr Lys Thr Glu 
            420                 425                 430         
Ala Tyr Asn Thr Asp Thr Ala Leu Asn Lys Val Thr Val Ile Gly Gly 
        435                 440                 445             
Asn Asn Ala Asp Ile Asn Ala Pro Tyr Gly Tyr Leu Lys Val Pro Gly 
    450                 455                 460                 
Asp Leu Asn Arg Gly Ala Gly Gly Asn Phe Ile Tyr Ala Cys Thr Phe 
465                 470                 475                 480 
Val Gly Lys 
            

<210>  291
<211>  483
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  291
Met Glu Asn Ile Asp Leu Pro Gln Gly Leu Val Asn Phe Ser Thr Gln 
1               5                   10                  15      
His Leu Gln Leu Ile Arg Phe Lys Ala Gly Leu Asn Glu Thr Val Leu 
            20                  25                  30          
Pro Gly Val Glu Ala Ile Gly Leu Gly Tyr Asn Pro Phe Ile Ser Tyr 
        35                  40                  45              
Ala Ser Val Asn Ser Gly Ala Val Gln Leu Phe Asp Trp Ala Thr Ala 
    50                  55                  60                  
Lys Lys Arg Glu Val Pro Phe Lys Ala Gly Tyr Phe Val Pro Glu Leu 
65                  70                  75                  80  
Val Asp Val Gln Gln Asn Asp Ser Ala Thr Phe Thr Asn Val Ser Gly 
                85                  90                  95      
Asn Thr Leu Ser Glu Tyr Gln Arg Ser Leu Ala Thr Ser Val Ala Ile 
            100                 105                 110         
Glu Gly Arg Tyr Asn Phe Phe Ser Gly Ser Leu Ser Thr Asp Phe Asp 
        115                 120                 125             
Ser Asn Ser Leu Arg Asn Ala Glu Asn Glu Phe Thr Arg Ile Gln Gln 
    130                 135                 140                 
Ser Ile Asn Leu Trp Ser Leu Arg Leu Pro Ser Val Lys Ser Leu Arg 
145                 150                 155                 160 
Glu Leu Met Leu Pro His Met Arg Gln Gln Leu Asp Glu Leu Asn Val 
                165                 170                 175     
Asn Asp Pro Lys Ala Ile Ser Arg Tyr Phe Asp Arg Val Gly Ser His 
            180                 185                 190         
Phe Leu Thr Gly Ile Val Met Gly Gly Arg Ala Ile Leu Ala Ser Ser 
        195                 200                 205             
Thr Asn Lys Leu Arg Val Lys Arg Asp Tyr Ser Val Ser Val Val Ala 
    210                 215                 220                 
Lys Ala Ser Tyr Glu Gly Leu Thr Gly Gln Leu Ser Ala Glu Ala Lys 
225                 230                 235                 240 
Ala Lys Tyr Gly Glu Ser Ile Ser Ser Phe Thr Gln Tyr Ser Asn Thr 
                245                 250                 255     
His Gln Glu Val Arg Gly Gly Asp Gly Ala Lys Ala His Gly Val Phe 
            260                 265                 270         
Ser Gly Lys Lys Glu Asp Phe Gln Ala Trp Val Asp Ser Val Ser Ala 
        275                 280                 285             
Ser Pro Asp Phe Val Asp Phe Val Pro Thr Ile Pro Met Gln Glu Ile 
    290                 295                 300                 
Trp Thr Leu Cys Ser Ser Glu Ala Gln Ala Glu Ala Met Arg Lys His 
305                 310                 315                 320 
Phe Asp Asp Val Trp Ala Pro Ala Gln Ser Glu Lys Phe Arg Val Lys 
                325                 330                 335     
Ala Asn Tyr Ile Asp Gln Leu Val Val Ile Thr Gly Gly Ser Ser Thr 
            340                 345                 350         
Ile Glu Pro Pro Val Gly Tyr Ser Lys Ile Glu Tyr Asp Leu Asn Ala 
        355                 360                 365             
Gly Ala Gly Gly Asp Phe Ile Tyr Leu Cys Tyr His Glu Gln Thr Trp 
    370                 375                 380                 
Gln Ala Asp Arg Pro Lys Asp Ala Val Thr Asp Ile Arg Ile Ile Phe 
385                 390                 395                 400 
Asn Lys Glu Pro Thr Pro Pro Gly Tyr Thr Lys Leu Pro Gln Asp Leu 
                405                 410                 415     
Asn Lys Gly Ala Gly Gly Asp Asp Val Phe Leu Cys Tyr Lys Thr Glu 
            420                 425                 430         
Ala Tyr Asn Thr Asp Thr Ala Ile Asn Lys Val Thr Val Ile Gly Gly 
        435                 440                 445             
Asn Asn Ala Asp Ile Asn Ala Pro Tyr Gly Tyr Leu Lys Val Pro Gly 
    450                 455                 460                 
Asp Leu Asn Arg Gly Ala Gly Gly Asn Phe Ile Tyr Ala Cys Thr Phe 
465                 470                 475                 480 
Val Gly Lys 
            

<210>  292
<211>  336
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  292
Met Glu Asn Ile Asp Leu Pro Gln Gly Leu Val Asn Phe Ser Thr Gln 
1               5                   10                  15      
His Leu Gln Leu Ile Arg Phe Lys Ala Gly Leu Asn Glu Thr Val Leu 
            20                  25                  30          
Pro Gly Val Glu Ala Ile Gly Leu Gly Tyr Asn Pro Phe Ile Ser Tyr 
        35                  40                  45              
Ala Ser Val Asn Ser Gly Ala Val Gln Leu Phe Asp Trp Ala Thr Ala 
    50                  55                  60                  
Lys Lys Arg Glu Val Pro Phe Lys Ala Gly Tyr Phe Val Pro Glu Leu 
65                  70                  75                  80  
Val Asp Val Gln Gln Asn Asp Ser Ala Thr Tyr Thr Asn Val Ser Gly 
                85                  90                  95      
Asn Thr Leu Ser Glu Tyr Gln Arg Ser Leu Ala Thr Ser Val Ala Ile 
            100                 105                 110         
Glu Gly Arg Tyr Asn Phe Phe Ser Gly Ser Leu Ser Thr Asp Phe Asp 
        115                 120                 125             
Ser Asn Ser Leu Arg Asn Ala Glu Asn Glu Phe Thr Arg Ile Gln Gln 
    130                 135                 140                 
Ser Ile Asn Leu Trp Ser Leu Arg Leu Pro Ser Val Lys Ser Leu Arg 
145                 150                 155                 160 
Glu Leu Met Leu Pro His Met Arg Gln Gln Leu Asp Glu Leu Asn Val 
                165                 170                 175     
Asn Asp Pro Lys Ala Ile Ser Arg Tyr Phe Asp Arg Val Gly Ser His 
            180                 185                 190         
Phe Leu Thr Gly Ile Val Met Gly Gly Arg Ala Ile Leu Ala Ser Ser 
        195                 200                 205             
Thr Asn Lys Leu Arg Val Lys Arg Asp Tyr Ser Val Ser Val Val Ala 
    210                 215                 220                 
Lys Ala Ser Tyr Glu Gly Leu Thr Gly Gln Leu Ser Ala Glu Ala Lys 
225                 230                 235                 240 
Ala Lys Tyr Gly Glu Ser Ile Ser Ser Phe Thr Gln Tyr Ser Asn Thr 
                245                 250                 255     
His Gln Glu Val Arg Gly Gly Asp Gly Ala Lys Ala His Gly Val Phe 
            260                 265                 270         
Ser Gly Lys Lys Glu Asp Phe Gln Ala Trp Val Asp Ser Val Ser Ala 
        275                 280                 285             
Ser Pro Asp Phe Val Asp Phe Val Pro Thr Ile Pro Met Gln Glu Ile 
    290                 295                 300                 
Trp Thr Leu Cys Ser Ser Glu Ala Gln Ala Glu Ala Met Arg Lys His 
305                 310                 315                 320 
Tyr Asp Asp Val Trp Ala Pro Ala Gln Ser Lys Val Pro Gly Gln Gly 
                325                 330                 335     

<210>  293
<211>  483
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  293
Met Glu Asn Ile Asp Leu Pro Gln Gly Leu Val Asn Phe Ser Thr Gln 
1               5                   10                  15      
His Leu Gln Leu Ile Arg Phe Lys Ala Gly Leu Asn Glu Thr Val Leu 
            20                  25                  30          
Pro Gly Val Glu Ala Ile Gly Leu Gly Tyr Asn Pro Phe Ile Ser Tyr 
        35                  40                  45              
Ala Ser Val Asn Ser Gly Ala Val Gln Leu Phe Asp Trp Ala Thr Ala 
    50                  55                  60                  
Lys Lys Arg Glu Val Pro Phe Lys Ala Gly Tyr Phe Val Pro Glu Ile 
65                  70                  75                  80  
Val Asp Val Gln Gln Asn Asp Ser Ala Thr Tyr Thr Asn Val Ser Gly 
                85                  90                  95      
Asn Thr Ile Ser Glu Tyr Gln Arg Ser Leu Ala Thr Ser Val Ala Ile 
            100                 105                 110         
Glu Gly Arg Tyr Asn Phe Phe Ser Gly Ser Leu Ser Thr Asp Phe Asp 
        115                 120                 125             
Ser Asn Ser Leu Arg Asn Ala Glu Asn Glu Phe Thr Arg Ile Gln Gln 
    130                 135                 140                 
Ser Ile Asn Leu Trp Ser Leu Arg Leu Pro Ser Val Lys Ser Leu Arg 
145                 150                 155                 160 
Glu Leu Met Leu Pro His Met Arg Gln Gln Leu Asp Glu Leu Asn Val 
                165                 170                 175     
Asn Asp Pro Lys Ala Ile Ser Arg Tyr Phe Asp Arg Val Gly Ser His 
            180                 185                 190         
Phe Leu Thr Gly Ile Val Met Gly Gly Arg Ala Ile Leu Ala Ser Ser 
        195                 200                 205             
Thr Asn Lys Leu Arg Val Lys Arg Asp Tyr Ser Val Ser Val Val Ala 
    210                 215                 220                 
Lys Ala Ser Tyr Glu Gly Leu Thr Gly Gln Leu Ser Ala Glu Ala Lys 
225                 230                 235                 240 
Ala Lys Tyr Gly Glu Ser Ile Ser Ser Phe Thr Gln Tyr Ser Asn Thr 
                245                 250                 255     
His Gln Glu Val Arg Gly Gly Asp Gly Ala Lys Ala His Gly Val Phe 
            260                 265                 270         
Ser Gly Lys Lys Glu Asp Phe Gln Ala Trp Val Asp Ser Val Ser Ala 
        275                 280                 285             
Ser Pro Asp Phe Val Asp Phe Val Pro Thr Ile Pro Met Gln Glu Ile 
    290                 295                 300                 
Trp Thr Leu Cys Ser Ser Glu Ala Gln Ala Glu Ala Met Arg Lys His 
305                 310                 315                 320 
Tyr Asp Asp Val Trp Ala Pro Ala Gln Ser Glu Lys Tyr Arg Val Lys 
                325                 330                 335     
Ala Asn Tyr Ile Asp Gln Leu Val Val Ile Thr Gly Gly Ser Ser Thr 
            340                 345                 350         
Ile Glu Pro Pro Val Gly Tyr Ser Lys Leu Glu Tyr Asp Leu Asn Ala 
        355                 360                 365             
Gly Ala Gly Gly Asp Phe Ile Tyr Leu Cys Tyr His Glu Gln Thr Trp 
    370                 375                 380                 
Gln Ala Asp Arg Pro Lys Asp Ala Val Thr Asp Ile Arg Ile Ile Phe 
385                 390                 395                 400 
Asn Lys Glu Pro Thr Pro Pro Gly Tyr Thr Lys Leu Pro Gln Asp Leu 
                405                 410                 415     
Asn Lys Gly Ala Gly Gly Asp Asp Val Phe Leu Cys Tyr Lys Thr Glu 
            420                 425                 430         
Ala Tyr Asn Thr Asp Thr Ala Leu Asn Lys Val Thr Val Ile Gly Gly 
        435                 440                 445             
Asn Asn Ala Asp Ile Asn Ala Pro Tyr Gly Tyr Leu Lys Val Pro Gly 
    450                 455                 460                 
Asp Leu Asn Arg Gly Ala Gly Gly Asn Phe Ile Tyr Ala Cys Thr Phe 
465                 470                 475                 480 
Val Gly Lys 
            

<210>  294
<211>  483
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  294
Met Glu Asn Ile Asp Leu Pro Gln Gly Leu Val Asn Phe Ser Thr Gln 
1               5                   10                  15      
His Leu Gln Leu Ile Arg Phe Lys Ala Gly Leu Asn Glu Thr Val Leu 
            20                  25                  30          
Pro Gly Val Glu Ala Ile Gly Leu Gly Tyr Asn Pro Phe Ile Ser Tyr 
        35                  40                  45              
Ala Ser Val Asn Ser Gly Ala Val Gln Leu Phe Asp Trp Ala Thr Ala 
    50                  55                  60                  
Lys Lys Arg Glu Val Pro Phe Lys Ala Gly Tyr Phe Val Pro Glu Leu 
65                  70                  75                  80  
Val Asp Val Gln Gln Asn Asp Ser Ala Thr Phe Thr Asn Val Ser Gly 
                85                  90                  95      
Asn Thr Ile Ser Glu Tyr Gln Arg Ser Leu Ala Thr Ser Val Ala Ile 
            100                 105                 110         
Glu Gly Arg Tyr Asn Phe Phe Ser Gly Ser Leu Ser Thr Asp Phe Asp 
        115                 120                 125             
Ser Asn Ser Leu Arg Asn Ala Glu Asn Glu Phe Thr Arg Ile Gln Gln 
    130                 135                 140                 
Ser Ile Asn Leu Trp Ser Leu Arg Leu Pro Ser Val Lys Ser Leu Arg 
145                 150                 155                 160 
Glu Leu Met Leu Pro His Met Arg Gln Gln Leu Asp Glu Leu Asn Val 
                165                 170                 175     
Asn Asp Pro Lys Ala Ile Ser Arg Tyr Phe Asp Arg Val Gly Ser His 
            180                 185                 190         
Phe Leu Thr Gly Ile Val Met Gly Gly Arg Ala Ile Leu Ala Ser Ser 
        195                 200                 205             
Thr Asn Lys Leu Arg Val Lys Arg Asp Tyr Ser Val Ser Val Val Ala 
    210                 215                 220                 
Lys Ala Ser Tyr Glu Gly Leu Thr Gly Gln Leu Ser Ala Glu Ala Lys 
225                 230                 235                 240 
Ala Lys Tyr Gly Glu Ser Ile Ser Ser Phe Thr Gln Tyr Ser Asn Thr 
                245                 250                 255     
His Gln Glu Val Arg Gly Gly Asp Gly Ala Lys Ala His Gly Val Phe 
            260                 265                 270         
Ser Gly Lys Lys Glu Asp Phe Gln Ala Trp Val Asp Ser Val Ser Ala 
        275                 280                 285             
Ser Pro Asp Phe Val Asp Phe Val Pro Thr Ile Pro Met Gln Glu Ile 
    290                 295                 300                 
Trp Thr Leu Cys Ser Ser Glu Ala Gln Ala Glu Ala Met Arg Lys His 
305                 310                 315                 320 
Tyr Asp Asp Val Trp Ala Pro Ala Gln Ser Glu Lys Phe Arg Val Lys 
                325                 330                 335     
Ala Asn Tyr Ile Asp Gln Leu Val Val Ile Thr Gly Gly Ser Ser Thr 
            340                 345                 350         
Ile Glu Pro Pro Val Gly Tyr Ser Lys Leu Glu Tyr Asp Leu Asn Ala 
        355                 360                 365             
Gly Ala Gly Gly Asp Phe Ile Tyr Leu Cys Tyr His Glu Gln Thr Trp 
    370                 375                 380                 
Gln Ala Asp Arg Pro Lys Asp Ala Val Thr Asp Ile Arg Ile Ile Phe 
385                 390                 395                 400 
Asn Lys Glu Pro Thr Pro Pro Gly Tyr Thr Lys Leu Pro Gln Asp Leu 
                405                 410                 415     
Asn Lys Gly Ala Gly Gly Asp Asp Val Phe Leu Cys Tyr Lys Thr Glu 
            420                 425                 430         
Ala Tyr Asn Thr Asp Thr Ala Ile Asn Lys Val Thr Val Ile Gly Gly 
        435                 440                 445             
Asn Asn Ala Asp Ile Asn Ala Pro Tyr Gly Tyr Leu Lys Val Pro Gly 
    450                 455                 460                 
Asp Leu Asn Arg Gly Ala Gly Gly Asn Phe Ile Tyr Ala Cys Thr Phe 
465                 470                 475                 480 
Val Gly Lys 
            

<210>  295
<211>  483
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  295
Met Glu Asn Ile Asp Leu Pro Gln Gly Leu Val Asn Phe Ser Thr Gln 
1               5                   10                  15      
His Leu Gln Leu Ile Arg Phe Lys Ala Gly Leu Asn Glu Thr Val Leu 
            20                  25                  30          
Pro Gly Val Glu Ala Ile Gly Leu Gly Tyr Asn Pro Phe Ile Ser Tyr 
        35                  40                  45              
Ala Ser Val Asn Ser Gly Ala Val Gln Leu Phe Asp Trp Ala Thr Ala 
    50                  55                  60                  
Lys Lys Arg Glu Val Pro Phe Lys Ala Gly Tyr Phe Val Pro Glu Ile 
65                  70                  75                  80  
Val Asp Val Gln Gln Asn Asp Ser Ala Thr Phe Thr Asn Val Ser Gly 
                85                  90                  95      
Asn Thr Ile Ser Glu Tyr Gln Arg Ser Leu Ala Thr Ser Val Ala Ile 
            100                 105                 110         
Glu Gly Arg Tyr Asn Phe Phe Ser Gly Ser Leu Ser Thr Asp Phe Asp 
        115                 120                 125             
Ser Asn Ser Leu Arg Asn Ala Glu Asn Glu Phe Thr Arg Ile Gln Gln 
    130                 135                 140                 
Ser Ile Asn Leu Trp Ser Leu Arg Leu Pro Ser Val Lys Ser Leu Arg 
145                 150                 155                 160 
Glu Leu Met Leu Pro His Met Arg Gln Gln Leu Asp Glu Leu Asn Val 
                165                 170                 175     
Asn Asp Pro Lys Ala Ile Ser Arg Tyr Phe Asp Arg Val Gly Ser His 
            180                 185                 190         
Phe Leu Thr Gly Ile Val Met Gly Gly Arg Ala Ile Leu Ala Ser Ser 
        195                 200                 205             
Thr Asn Lys Leu Arg Val Lys Arg Asp Tyr Ser Val Ser Val Val Ala 
    210                 215                 220                 
Lys Ala Ser Tyr Glu Gly Leu Thr Gly Gln Leu Ser Ala Glu Ala Lys 
225                 230                 235                 240 
Ala Lys Tyr Gly Glu Ser Ile Ser Ser Phe Thr Gln Tyr Ser Asn Thr 
                245                 250                 255     
His Gln Glu Val Arg Gly Gly Asp Gly Ala Lys Ala His Gly Val Phe 
            260                 265                 270         
Ser Gly Lys Lys Glu Asp Phe Gln Ala Trp Val Asp Ser Val Ser Ala 
        275                 280                 285             
Ser Pro Asp Phe Val Asp Phe Val Pro Thr Ile Pro Met Gln Glu Ile 
    290                 295                 300                 
Trp Thr Leu Cys Ser Ser Glu Ala Gln Ala Glu Ala Met Arg Lys His 
305                 310                 315                 320 
Phe Asp Asp Val Trp Ala Pro Ala Gln Ser Glu Lys Tyr Arg Val Lys 
                325                 330                 335     
Ala Asn Tyr Ile Asp Gln Leu Val Val Ile Thr Gly Gly Ser Ser Thr 
            340                 345                 350         
Ile Glu Pro Pro Val Gly Tyr Ser Lys Ile Glu Tyr Asp Leu Asn Ala 
        355                 360                 365             
Gly Ala Gly Gly Asp Phe Ile Tyr Leu Cys Tyr His Glu Gln Thr Trp 
    370                 375                 380                 
Gln Ala Asp Arg Pro Lys Asp Ala Val Thr Asp Ile Arg Ile Ile Phe 
385                 390                 395                 400 
Asn Lys Glu Pro Thr Pro Pro Gly Tyr Thr Lys Leu Pro Gln Asp Leu 
                405                 410                 415     
Asn Lys Gly Ala Gly Gly Asp Asp Val Phe Leu Cys Tyr Lys Thr Glu 
            420                 425                 430         
Ala Tyr Asn Thr Asp Thr Ala Leu Asn Lys Val Thr Val Ile Gly Gly 
        435                 440                 445             
Asn Asn Ala Asp Ile Asn Ala Pro Tyr Gly Tyr Leu Lys Val Pro Gly 
    450                 455                 460                 
Asp Leu Asn Arg Gly Ala Gly Gly Asn Phe Ile Tyr Ala Cys Thr Phe 
465                 470                 475                 480 
Val Gly Lys 
            

<210>  296
<211>  483
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  296
Met Glu Asn Ile Asp Leu Pro Gln Gly Leu Val Asn Phe Ser Thr Gln 
1               5                   10                  15      
His Leu Gln Leu Ile Arg Phe Lys Ala Gly Leu Asn Glu Thr Val Leu 
            20                  25                  30          
Pro Gly Val Glu Ala Ile Gly Leu Gly Tyr Asn Pro Phe Ile Ser Tyr 
        35                  40                  45              
Ala Ser Val Asn Ser Gly Ala Val Gln Leu Phe Asp Trp Ala Thr Ala 
    50                  55                  60                  
Lys Lys Arg Glu Val Pro Phe Lys Ala Gly Tyr Phe Val Pro Glu Leu 
65                  70                  75                  80  
Val Asp Val Gln Gln Asn Asp Ser Ala Thr Tyr Thr Asn Val Ser Gly 
                85                  90                  95      
Asn Thr Ile Ser Glu Tyr Gln Arg Ser Leu Ala Thr Ser Val Ala Ile 
            100                 105                 110         
Glu Gly Arg Tyr Asn Phe Phe Ser Gly Ser Leu Ser Thr Asp Phe Asp 
        115                 120                 125             
Ser Asn Ser Leu Arg Asn Ala Glu Asn Glu Phe Thr Arg Ile Gln Gln 
    130                 135                 140                 
Ser Ile Asn Leu Trp Ser Leu Arg Leu Pro Ser Val Lys Ser Leu Arg 
145                 150                 155                 160 
Glu Leu Met Leu Pro His Met Arg Gln Gln Leu Asp Glu Leu Asn Val 
                165                 170                 175     
Asn Asp Pro Lys Ala Ile Ser Arg Tyr Phe Asp Arg Val Gly Ser His 
            180                 185                 190         
Phe Leu Thr Gly Ile Val Met Gly Gly Arg Ala Ile Leu Ala Ser Ser 
        195                 200                 205             
Thr Asn Lys Leu Arg Val Lys Arg Asp Tyr Ser Val Ser Val Val Ala 
    210                 215                 220                 
Lys Ala Ser Tyr Glu Gly Leu Thr Gly Gln Leu Ser Ala Glu Ala Lys 
225                 230                 235                 240 
Ala Lys Tyr Gly Glu Ser Ile Ser Ser Phe Thr Gln Tyr Ser Asn Thr 
                245                 250                 255     
His Gln Glu Val Arg Gly Gly Asp Gly Ala Lys Ala His Gly Val Phe 
            260                 265                 270         
Ser Gly Lys Lys Glu Asp Phe Gln Ala Trp Val Asp Ser Val Ser Ala 
        275                 280                 285             
Ser Pro Asp Phe Val Asp Phe Val Pro Thr Ile Pro Met Gln Glu Ile 
    290                 295                 300                 
Trp Thr Leu Cys Ser Ser Glu Ala Gln Ala Glu Ala Met Arg Lys His 
305                 310                 315                 320 
Tyr Asp Asp Val Trp Ala Pro Ala Gln Ser Glu Lys Phe Arg Val Lys 
                325                 330                 335     
Ala Asn Tyr Ile Asp Gln Leu Val Val Leu Thr Gly Gly Ser Ser Thr 
            340                 345                 350         
Ile Glu Pro Pro Val Gly Tyr Ser Lys Ile Glu Tyr Asp Leu Asn Ala 
        355                 360                 365             
Gly Ala Gly Gly Asp Phe Ile Tyr Leu Cys Tyr His Glu Gln Thr Trp 
    370                 375                 380                 
Gln Ala Asp Arg Pro Lys Asp Ala Val Thr Asp Ile Arg Ile Ile Phe 
385                 390                 395                 400 
Asn Lys Glu Pro Thr Pro Pro Gly Tyr Thr Lys Leu Pro Gln Asp Leu 
                405                 410                 415     
Asn Lys Gly Ala Gly Gly Asp Asp Val Phe Leu Cys Tyr Lys Thr Glu 
            420                 425                 430         
Ala Phe Asn Thr Asp Thr Ala Leu Asn Lys Val Thr Val Ile Gly Gly 
        435                 440                 445             
Asn Asn Ala Asp Ile Asn Ala Pro Tyr Gly Tyr Leu Lys Val Pro Gly 
    450                 455                 460                 
Asp Leu Asn Arg Gly Ala Gly Gly Asn Phe Ile Tyr Ala Cys Thr Phe 
465                 470                 475                 480 
Val Gly Lys 
            

<210>  297
<211>  483
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  297
Met Glu Asn Ile Asp Leu Pro Gln Gly Leu Val Asn Phe Ser Thr Gln 
1               5                   10                  15      
His Leu Gln Leu Ile Arg Phe Lys Ala Gly Leu Asn Glu Thr Val Leu 
            20                  25                  30          
Pro Gly Val Glu Ala Ile Gly Leu Gly Tyr Asn Pro Phe Ile Ser Tyr 
        35                  40                  45              
Ala Ser Val Asn Ser Gly Ala Val Gln Leu Phe Asp Trp Ala Thr Ala 
    50                  55                  60                  
Lys Lys Arg Glu Val Pro Phe Lys Ala Gly Tyr Phe Val Pro Glu Leu 
65                  70                  75                  80  
Val Asp Val Gln Gln Asn Asp Ser Ala Thr Tyr Thr Asn Val Ser Gly 
                85                  90                  95      
Asn Thr Leu Ser Glu Tyr Gln Arg Ser Leu Ala Thr Ser Val Ala Ile 
            100                 105                 110         
Glu Gly Arg Tyr Asn Phe Phe Ser Gly Ser Leu Ser Thr Asp Phe Asp 
        115                 120                 125             
Ser Asn Ser Leu Arg Asn Ala Glu Asn Glu Phe Thr Arg Ile Gln Gln 
    130                 135                 140                 
Ser Ile Asn Leu Trp Ser Leu Arg Leu Pro Ser Val Lys Ser Leu Arg 
145                 150                 155                 160 
Glu Leu Met Leu Pro His Met Arg Gln Gln Leu Asp Glu Leu Asn Val 
                165                 170                 175     
Asn Asp Pro Lys Ala Ile Ser Arg Tyr Phe Asp Arg Val Gly Ser His 
            180                 185                 190         
Phe Leu Thr Gly Ile Val Met Gly Gly Arg Ala Ile Leu Ala Ser Ser 
        195                 200                 205             
Thr Asn Lys Leu Arg Val Lys Arg Asp Tyr Ser Val Ser Val Val Ala 
    210                 215                 220                 
Lys Ala Ser Tyr Glu Gly Leu Thr Gly Gln Leu Ser Ala Glu Ala Lys 
225                 230                 235                 240 
Ala Lys Tyr Gly Glu Ser Ile Ser Ser Phe Thr Gln Tyr Ser Asn Thr 
                245                 250                 255     
His Gln Glu Val Arg Gly Gly Asp Gly Ala Lys Ala His Gly Val Phe 
            260                 265                 270         
Ser Gly Lys Lys Glu Asp Phe Gln Ala Trp Val Asp Ser Val Ser Ala 
        275                 280                 285             
Ser Pro Asp Phe Val Asp Phe Val Pro Thr Ile Pro Met Gln Glu Ile 
    290                 295                 300                 
Trp Thr Leu Cys Ser Ser Glu Ala Gln Ala Glu Ala Met Arg Lys His 
305                 310                 315                 320 
Phe Asp Asp Val Trp Ala Pro Ala Gln Ser Glu Lys Phe Arg Val Lys 
                325                 330                 335     
Ala Asn Tyr Ile Asp Gln Leu Val Val Ile Thr Gly Gly Ser Ser Thr 
            340                 345                 350         
Ile Glu Pro Pro Val Gly Tyr Ser Lys Leu Glu Tyr Asp Leu Asn Ala 
        355                 360                 365             
Gly Ala Gly Gly Asp Phe Ile Tyr Leu Cys Tyr His Glu Gln Thr Trp 
    370                 375                 380                 
Gln Ala Asp Arg Pro Lys Asp Ala Val Thr Asp Ile Arg Ile Ile Phe 
385                 390                 395                 400 
Asn Lys Glu Pro Thr Pro Pro Gly Tyr Thr Lys Leu Pro Gln Asp Leu 
                405                 410                 415     
Asn Lys Gly Ala Gly Gly Asp Asp Val Phe Leu Cys Tyr Lys Thr Glu 
            420                 425                 430         
Ala Tyr Asn Thr Asp Thr Ala Leu Asn Lys Val Thr Val Ile Gly Gly 
        435                 440                 445             
Asn Asn Ala Asp Ile Asn Ala Pro Tyr Gly Tyr Leu Lys Val Pro Gly 
    450                 455                 460                 
Asp Leu Asn Arg Gly Ala Gly Gly Asn Phe Ile Tyr Ala Cys Thr Phe 
465                 470                 475                 480 
Val Gly Lys 
            

<210>  298
<211>  483
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  298
Met Glu Asn Ile Asp Leu Pro Gln Gly Leu Val Asn Phe Ser Thr Gln 
1               5                   10                  15      
His Leu Gln Leu Ile Arg Phe Lys Ala Gly Leu Asn Glu Thr Val Leu 
            20                  25                  30          
Pro Gly Val Glu Ala Ile Gly Leu Gly Tyr Asn Pro Phe Ile Ser Tyr 
        35                  40                  45              
Ala Ser Val Asn Ser Gly Ala Val Gln Leu Phe Asp Trp Ala Thr Ala 
    50                  55                  60                  
Lys Lys Arg Glu Val Pro Phe Lys Ala Gly Tyr Phe Val Pro Glu Leu 
65                  70                  75                  80  
Val Asp Val Gln Gln Asn Asp Ser Ala Thr Tyr Thr Asn Val Ser Gly 
                85                  90                  95      
Asn Thr Ile Ser Glu Tyr Gln Arg Ser Leu Ala Thr Ser Val Ala Ile 
            100                 105                 110         
Glu Gly Arg Tyr Asn Phe Phe Ser Gly Ser Leu Ser Thr Asp Phe Asp 
        115                 120                 125             
Ser Asn Ser Leu Arg Asn Ala Glu Asn Glu Phe Thr Arg Ile Gln Gln 
    130                 135                 140                 
Ser Ile Asn Leu Trp Ser Leu Arg Leu Pro Ser Val Lys Ser Leu Arg 
145                 150                 155                 160 
Glu Leu Met Leu Pro His Met Arg Gln Gln Leu Asp Glu Leu Asn Val 
                165                 170                 175     
Asn Asp Pro Lys Ala Ile Ser Arg Tyr Phe Asp Arg Val Gly Ser His 
            180                 185                 190         
Phe Leu Thr Gly Ile Val Met Gly Gly Arg Ala Ile Leu Ala Ser Ser 
        195                 200                 205             
Thr Asn Lys Leu Arg Val Lys Arg Asp Tyr Ser Val Ser Val Val Ala 
    210                 215                 220                 
Lys Ala Ser Tyr Glu Gly Leu Thr Gly Gln Leu Ser Ala Glu Ala Lys 
225                 230                 235                 240 
Ala Lys Tyr Gly Glu Ser Ile Ser Ser Phe Thr Gln Tyr Ser Asn Thr 
                245                 250                 255     
His Gln Glu Val Arg Gly Gly Asp Gly Ala Lys Ala His Gly Val Phe 
            260                 265                 270         
Ser Gly Lys Lys Glu Asp Phe Gln Ala Trp Val Asp Ser Val Ser Ala 
        275                 280                 285             
Ser Pro Asp Phe Val Asp Phe Val Pro Thr Ile Pro Met Gln Glu Ile 
    290                 295                 300                 
Trp Thr Leu Cys Ser Ser Glu Ala Gln Ala Glu Ala Met Arg Lys His 
305                 310                 315                 320 
Tyr Asp Asp Val Trp Ala Pro Ala Gln Ser Glu Lys Tyr Arg Val Lys 
                325                 330                 335     
Ala Asn Phe Ile Asp Gln Leu Val Val Ile Thr Gly Gly Ser Ser Thr 
            340                 345                 350         
Ile Glu Pro Pro Val Gly Tyr Ser Lys Ile Glu Tyr Asp Leu Asn Ala 
        355                 360                 365             
Gly Ala Gly Gly Asp Phe Ile Tyr Leu Cys Tyr His Glu Gln Thr Trp 
    370                 375                 380                 
Gln Ala Asp Arg Pro Lys Asp Ala Val Thr Asp Ile Arg Ile Ile Phe 
385                 390                 395                 400 
Asn Lys Glu Pro Thr Pro Pro Gly Tyr Thr Lys Leu Pro Gln Asp Leu 
                405                 410                 415     
Asn Lys Gly Ala Gly Gly Asp Asp Val Phe Leu Cys Tyr Lys Thr Glu 
            420                 425                 430         
Ala Tyr Asn Thr Asp Thr Ala Ile Asn Lys Val Thr Val Ile Gly Gly 
        435                 440                 445             
Asn Asn Ala Asp Ile Asn Ala Pro Tyr Gly Tyr Leu Lys Val Pro Gly 
    450                 455                 460                 
Asp Leu Asn Arg Gly Ala Gly Gly Asn Phe Ile Tyr Ala Cys Thr Phe 
465                 470                 475                 480 
Val Gly Lys 
            

<210>  299
<211>  483
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  299
Met Glu Asn Ile Asp Leu Pro Gln Gly Leu Val Asn Phe Ser Thr Gln 
1               5                   10                  15      
His Leu Gln Leu Ile Arg Phe Lys Ala Gly Leu Asn Glu Thr Val Leu 
            20                  25                  30          
Pro Gly Val Glu Ala Ile Gly Leu Gly Tyr Asn Pro Phe Ile Ser Tyr 
        35                  40                  45              
Ala Ser Val Asn Ser Gly Ala Val Gln Leu Phe Asp Trp Ala Thr Ala 
    50                  55                  60                  
Lys Lys Arg Glu Val Pro Phe Lys Ala Gly Tyr Phe Val Pro Glu Leu 
65                  70                  75                  80  
Val Asp Val Gln Gln Asn Asp Ser Ala Thr Tyr Thr Asn Val Ser Gly 
                85                  90                  95      
Asn Thr Leu Ser Glu Tyr Gln Arg Ser Leu Ala Thr Ser Val Ala Ile 
            100                 105                 110         
Glu Gly Arg Tyr Asn Phe Phe Ser Gly Ser Leu Ser Thr Asp Phe Asp 
        115                 120                 125             
Ser Asn Ser Leu Arg Asn Ala Glu Asn Glu Phe Thr Arg Ile Gln Gln 
    130                 135                 140                 
Ser Ile Asn Leu Trp Ser Leu Arg Leu Pro Ser Val Lys Ser Leu Arg 
145                 150                 155                 160 
Glu Leu Met Leu Pro His Met Arg Gln Gln Leu Asp Glu Leu Asn Val 
                165                 170                 175     
Asn Asp Pro Lys Ala Ile Ser Arg Tyr Phe Asp Arg Val Gly Ser His 
            180                 185                 190         
Phe Leu Thr Gly Ile Val Met Gly Gly Arg Ala Ile Leu Ala Ser Ser 
        195                 200                 205             
Thr Asn Lys Leu Arg Val Lys Arg Asp Tyr Ser Val Ser Val Val Ala 
    210                 215                 220                 
Lys Ala Ser Tyr Glu Gly Leu Thr Gly Gln Leu Ser Ala Glu Ala Lys 
225                 230                 235                 240 
Ala Lys Tyr Gly Glu Ser Ile Ser Ser Phe Thr Gln Tyr Ser Asn Thr 
                245                 250                 255     
His Gln Glu Val Arg Gly Gly Asp Gly Ala Lys Ala His Gly Val Phe 
            260                 265                 270         
Ser Gly Lys Lys Glu Asp Phe Gln Ala Trp Val Asp Ser Val Ser Ala 
        275                 280                 285             
Ser Pro Asp Phe Val Asp Phe Val Pro Thr Ile Pro Met Gln Glu Ile 
    290                 295                 300                 
Trp Thr Leu Cys Ser Ser Glu Ala Gln Ala Glu Ala Met Arg Lys His 
305                 310                 315                 320 
Tyr Asp Asp Val Trp Ala Pro Ala Gln Ser Glu Lys Phe Arg Val Lys 
                325                 330                 335     
Ala Asn Tyr Ile Asp Gln Leu Val Val Ile Thr Gly Gly Ser Ser Thr 
            340                 345                 350         
Leu Glu Pro Pro Val Gly Tyr Ser Lys Ile Glu Tyr Asp Leu Asn Ala 
        355                 360                 365             
Gly Ala Gly Gly Asp Phe Ile Tyr Leu Cys Tyr His Glu Gln Thr Trp 
    370                 375                 380                 
Gln Ala Asp Arg Pro Lys Asp Ala Val Thr Asp Ile Arg Ile Ile Phe 
385                 390                 395                 400 
Asn Lys Glu Pro Thr Pro Pro Gly Tyr Thr Lys Leu Pro Gln Asp Leu 
                405                 410                 415     
Asn Lys Gly Ala Gly Gly Asp Asp Val Phe Leu Cys Tyr Lys Thr Glu 
            420                 425                 430         
Ala Phe Asn Thr Asp Thr Ala Ile Asn Lys Val Thr Val Leu Gly Gly 
        435                 440                 445             
Asn Asn Ala Asp Ile Asn Ala Pro Tyr Gly Tyr Leu Lys Val Pro Gly 
    450                 455                 460                 
Asp Leu Asn Arg Gly Ala Gly Gly Asn Phe Ile Tyr Ala Cys Thr Phe 
465                 470                 475                 480 
Val Gly Lys 
            

<210>  300
<211>  483
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  300
Met Glu Asn Ile Asp Leu Pro Gln Gly Leu Val Asn Phe Ser Thr Gln 
1               5                   10                  15      
His Leu Gln Leu Ile Arg Phe Lys Ala Gly Leu Asn Glu Thr Val Leu 
            20                  25                  30          
Pro Gly Val Glu Ala Ile Gly Leu Gly Tyr Asn Pro Phe Ile Ser Tyr 
        35                  40                  45              
Ala Ser Val Asn Ser Gly Ala Val Gln Leu Phe Asp Trp Ala Thr Ala 
    50                  55                  60                  
Lys Lys Arg Glu Val Pro Phe Lys Ala Gly Tyr Phe Val Pro Glu Leu 
65                  70                  75                  80  
Val Asp Val Gln Gln Asn Asp Ser Ala Thr Tyr Thr Asn Val Ser Gly 
                85                  90                  95      
Asn Thr Ile Ser Glu Tyr Gln Arg Ser Leu Ala Thr Ser Val Ala Ile 
            100                 105                 110         
Glu Gly Arg Tyr Asn Phe Phe Ser Gly Ser Leu Ser Thr Asp Phe Asp 
        115                 120                 125             
Ser Asn Ser Leu Arg Asn Ala Glu Asn Glu Phe Thr Arg Ile Gln Gln 
    130                 135                 140                 
Ser Ile Asn Leu Trp Ser Leu Arg Leu Pro Ser Val Lys Ser Leu Arg 
145                 150                 155                 160 
Glu Leu Met Leu Pro His Met Arg Gln Gln Leu Asp Glu Leu Asn Val 
                165                 170                 175     
Asn Asp Pro Lys Ala Ile Ser Arg Tyr Phe Asp Arg Val Gly Ser His 
            180                 185                 190         
Phe Leu Thr Gly Ile Val Met Gly Gly Arg Ala Ile Leu Ala Ser Ser 
        195                 200                 205             
Thr Asn Lys Leu Arg Val Lys Arg Asp Tyr Ser Val Ser Val Val Ala 
    210                 215                 220                 
Lys Ala Ser Tyr Glu Gly Leu Thr Gly Gln Leu Ser Ala Glu Ala Lys 
225                 230                 235                 240 
Ala Lys Tyr Gly Glu Ser Ile Ser Ser Phe Thr Gln Tyr Ser Asn Thr 
                245                 250                 255     
His Gln Glu Val Arg Gly Gly Asp Gly Ala Lys Ala His Gly Val Phe 
            260                 265                 270         
Ser Gly Lys Lys Glu Asp Phe Gln Ala Trp Val Asp Ser Val Ser Ala 
        275                 280                 285             
Ser Pro Asp Phe Val Asp Phe Val Pro Thr Ile Pro Met Gln Glu Ile 
    290                 295                 300                 
Trp Thr Leu Cys Ser Ser Glu Ala Gln Ala Glu Ala Met Arg Lys His 
305                 310                 315                 320 
Tyr Asp Asp Val Trp Ala Pro Ala Gln Ser Glu Lys Phe Arg Val Lys 
                325                 330                 335     
Ala Asn Tyr Ile Asp Gln Leu Val Val Ile Thr Gly Gly Ser Ser Thr 
            340                 345                 350         
Ile Glu Pro Pro Val Gly Tyr Ser Lys Ile Glu Tyr Asp Leu Asn Ala 
        355                 360                 365             
Gly Ala Gly Gly Asp Phe Ile Tyr Leu Cys Tyr His Glu Gln Thr Trp 
    370                 375                 380                 
Gln Ala Asp Arg Pro Lys Asp Ala Val Thr Asp Ile Arg Ile Ile Phe 
385                 390                 395                 400 
Asn Lys Glu Pro Thr Pro Pro Gly Tyr Thr Lys Leu Pro Gln Asp Leu 
                405                 410                 415     
Asn Lys Gly Ala Gly Gly Asp Asp Val Phe Leu Cys Tyr Lys Thr Glu 
            420                 425                 430         
Ala Tyr Asn Thr Asp Thr Ala Leu Asn Lys Val Thr Val Ile Gly Gly 
        435                 440                 445             
Asn Asn Ala Asp Ile Asn Ala Pro Tyr Gly Tyr Leu Lys Val Pro Gly 
    450                 455                 460                 
Asp Leu Asn Arg Gly Ala Gly Gly Asn Phe Ile Tyr Ala Cys Thr Phe 
465                 470                 475                 480 
Val Gly Lys 
            

<210>  301
<211>  483
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  301
Met Glu Asn Ile Asp Leu Pro Gln Gly Leu Val Asn Phe Ser Thr Gln 
1               5                   10                  15      
His Leu Gln Leu Ile Arg Phe Lys Ala Gly Leu Asn Glu Thr Val Leu 
            20                  25                  30          
Pro Gly Val Glu Ala Ile Gly Leu Gly Tyr Asn Pro Phe Ile Ser Tyr 
        35                  40                  45              
Ala Ser Val Asn Ser Gly Ala Val Gln Leu Phe Asp Trp Ala Thr Ala 
    50                  55                  60                  
Lys Lys Arg Glu Val Pro Phe Lys Ala Gly Tyr Phe Val Pro Glu Leu 
65                  70                  75                  80  
Val Asp Val Gln Gln Asn Asp Ser Ala Thr Phe Thr Asn Val Ser Gly 
                85                  90                  95      
Asn Thr Ile Ser Glu Tyr Gln Arg Ser Leu Ala Thr Ser Val Ala Ile 
            100                 105                 110         
Glu Gly Arg Tyr Asn Phe Phe Ser Gly Ser Leu Ser Thr Asp Phe Asp 
        115                 120                 125             
Ser Asn Ser Leu Arg Asn Ala Glu Asn Glu Phe Thr Arg Ile Gln Gln 
    130                 135                 140                 
Ser Ile Asn Leu Trp Ser Leu Arg Leu Pro Ser Val Lys Ser Leu Arg 
145                 150                 155                 160 
Glu Leu Met Leu Pro His Met Arg Gln Gln Leu Asp Glu Leu Asn Val 
                165                 170                 175     
Asn Asp Pro Lys Ala Ile Ser Arg Tyr Phe Asp Arg Val Gly Ser His 
            180                 185                 190         
Phe Leu Thr Gly Ile Val Met Gly Gly Arg Ala Ile Leu Ala Ser Ser 
        195                 200                 205             
Thr Asn Lys Leu Arg Val Lys Arg Asp Tyr Ser Val Ser Val Val Ala 
    210                 215                 220                 
Lys Ala Ser Tyr Glu Gly Leu Thr Gly Gln Leu Ser Ala Glu Ala Lys 
225                 230                 235                 240 
Ala Lys Tyr Gly Glu Ser Ile Ser Ser Phe Thr Gln Tyr Ser Asn Thr 
                245                 250                 255     
His Gln Glu Val Arg Gly Gly Asp Gly Ala Lys Ala His Gly Val Phe 
            260                 265                 270         
Ser Gly Lys Lys Glu Asp Phe Gln Ala Trp Val Asp Ser Val Ser Ala 
        275                 280                 285             
Ser Pro Asp Phe Val Asp Phe Val Pro Thr Ile Pro Met Gln Glu Ile 
    290                 295                 300                 
Trp Thr Leu Cys Ser Ser Glu Ala Gln Ala Glu Ala Met Arg Lys His 
305                 310                 315                 320 
Tyr Asp Asp Val Trp Ala Pro Ala Gln Ser Glu Lys Phe Arg Val Lys 
                325                 330                 335     
Ala Asn Tyr Ile Asp Gln Leu Val Val Leu Thr Gly Gly Ser Ser Thr 
            340                 345                 350         
Ile Glu Pro Pro Val Gly Tyr Ser Lys Ile Glu Tyr Asp Leu Asn Ala 
        355                 360                 365             
Gly Ala Gly Gly Asp Phe Ile Tyr Leu Cys Tyr His Glu Gln Thr Trp 
    370                 375                 380                 
Gln Ala Asp Arg Pro Lys Asp Ala Val Thr Asp Ile Arg Ile Ile Phe 
385                 390                 395                 400 
Asn Lys Glu Pro Thr Pro Pro Gly Tyr Thr Lys Leu Pro Gln Asp Leu 
                405                 410                 415     
Asn Lys Gly Ala Gly Gly Asp Asp Val Phe Leu Cys Tyr Lys Thr Glu 
            420                 425                 430         
Ala Tyr Asn Thr Asp Thr Ala Leu Asn Lys Val Thr Val Ile Gly Gly 
        435                 440                 445             
Asn Asn Ala Asp Ile Asn Ala Pro Phe Gly Tyr Leu Lys Val Pro Gly 
    450                 455                 460                 
Asp Leu Asn Arg Gly Ala Gly Gly Asn Phe Ile Tyr Ala Cys Thr Phe 
465                 470                 475                 480 
Val Gly Lys 
            

<210>  302
<211>  483
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  302
Met Glu Asn Ile Asp Leu Pro Gln Gly Leu Val Asn Phe Ser Thr Gln 
1               5                   10                  15      
His Leu Gln Leu Ile Arg Phe Lys Ala Gly Leu Asn Glu Thr Val Leu 
            20                  25                  30          
Pro Gly Val Glu Ala Ile Gly Leu Gly Tyr Asn Pro Phe Ile Ser Tyr 
        35                  40                  45              
Ala Ser Val Asn Ser Gly Ala Val Gln Leu Phe Asp Trp Ala Thr Ala 
    50                  55                  60                  
Lys Lys Arg Glu Val Pro Phe Lys Ala Gly Tyr Phe Val Pro Glu Leu 
65                  70                  75                  80  
Val Asp Val Gln Gln Asn Asp Ser Ala Thr Tyr Thr Asn Val Ser Gly 
                85                  90                  95      
Asn Thr Ile Ser Glu Tyr Gln Arg Ser Leu Ala Thr Ser Val Ala Ile 
            100                 105                 110         
Glu Gly Arg Tyr Asn Phe Phe Ser Gly Ser Leu Ser Thr Asp Phe Asp 
        115                 120                 125             
Ser Asn Ser Leu Arg Asn Ala Glu Asn Glu Phe Thr Arg Ile Gln Gln 
    130                 135                 140                 
Ser Ile Asn Leu Trp Ser Leu Arg Leu Pro Ser Val Lys Ser Leu Arg 
145                 150                 155                 160 
Glu Leu Met Leu Pro His Met Arg Gln Gln Leu Asp Glu Leu Asn Val 
                165                 170                 175     
Asn Asp Pro Lys Ala Ile Ser Arg Tyr Phe Asp Arg Val Gly Ser His 
            180                 185                 190         
Phe Leu Thr Gly Ile Val Met Gly Gly Arg Ala Ile Leu Ala Ser Ser 
        195                 200                 205             
Thr Asn Lys Leu Arg Val Lys Arg Asp Tyr Ser Val Ser Val Val Ala 
    210                 215                 220                 
Lys Ala Ser Tyr Glu Gly Leu Thr Gly Gln Leu Ser Ala Glu Ala Lys 
225                 230                 235                 240 
Ala Lys Tyr Gly Glu Ser Ile Ser Ser Phe Thr Gln Tyr Ser Asn Thr 
                245                 250                 255     
His Gln Glu Val Arg Gly Gly Asp Gly Ala Lys Ala His Gly Val Phe 
            260                 265                 270         
Ser Gly Lys Lys Glu Asp Phe Gln Ala Trp Val Asp Ser Val Ser Ala 
        275                 280                 285             
Ser Pro Asp Phe Val Asp Phe Val Pro Thr Ile Pro Met Gln Glu Ile 
    290                 295                 300                 
Trp Thr Leu Cys Ser Ser Glu Ala Gln Ala Glu Ala Met Arg Lys His 
305                 310                 315                 320 
Tyr Asp Asp Val Trp Ala Pro Ala Gln Ser Glu Lys Tyr Arg Val Lys 
                325                 330                 335     
Ala Asn Tyr Leu Asp Gln Leu Val Val Ile Thr Gly Gly Ser Ser Thr 
            340                 345                 350         
Ile Glu Pro Pro Val Gly Tyr Ser Lys Leu Glu Tyr Asp Leu Asn Ala 
        355                 360                 365             
Gly Ala Gly Gly Asp Phe Ile Tyr Leu Cys Tyr His Glu Gln Thr Trp 
    370                 375                 380                 
Gln Ala Asp Arg Pro Lys Asp Ala Val Thr Asp Ile Arg Ile Ile Phe 
385                 390                 395                 400 
Asn Lys Glu Pro Thr Pro Pro Gly Tyr Thr Lys Leu Pro Gln Asp Leu 
                405                 410                 415     
Asn Lys Gly Ala Gly Gly Asp Asp Val Phe Leu Cys Tyr Lys Thr Glu 
            420                 425                 430         
Ala Phe Asn Thr Asp Thr Ala Ile Asn Lys Val Thr Val Ile Gly Gly 
        435                 440                 445             
Asn Asn Ala Asp Ile Asn Ala Pro Tyr Gly Tyr Leu Lys Val Pro Gly 
    450                 455                 460                 
Asp Leu Asn Arg Gly Ala Gly Gly Asn Phe Ile Tyr Ala Cys Thr Phe 
465                 470                 475                 480 
Val Gly Lys 
            

<210>  303
<211>  483
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  303
Met Glu Asn Ile Asp Leu Pro Gln Gly Leu Val Asn Phe Ser Thr Gln 
1               5                   10                  15      
His Leu Gln Leu Ile Arg Phe Lys Ala Gly Leu Asn Glu Thr Val Leu 
            20                  25                  30          
Pro Gly Val Glu Ala Ile Gly Leu Gly Tyr Asn Pro Phe Ile Ser Tyr 
        35                  40                  45              
Ala Ser Val Asn Ser Gly Ala Val Gln Leu Phe Asp Trp Ala Thr Ala 
    50                  55                  60                  
Lys Lys Arg Glu Val Pro Phe Lys Ala Gly Tyr Phe Val Pro Glu Leu 
65                  70                  75                  80  
Val Asp Val Gln Gln Asn Asp Ser Ala Thr Tyr Thr Asn Val Ser Gly 
                85                  90                  95      
Asn Thr Ile Ser Glu Tyr Gln Arg Ser Leu Ala Thr Ser Val Ala Ile 
            100                 105                 110         
Glu Gly Arg Tyr Asn Phe Phe Ser Gly Ser Leu Ser Thr Asp Phe Asp 
        115                 120                 125             
Ser Asn Ser Leu Arg Asn Ala Glu Asn Glu Phe Thr Arg Ile Gln Gln 
    130                 135                 140                 
Ser Ile Asn Leu Trp Ser Leu Arg Leu Pro Ser Val Lys Ser Leu Arg 
145                 150                 155                 160 
Glu Leu Met Leu Pro His Met Arg Gln Gln Leu Asp Glu Leu Asn Val 
                165                 170                 175     
Asn Asp Pro Lys Ala Ile Ser Arg Tyr Phe Asp Arg Val Gly Ser His 
            180                 185                 190         
Phe Leu Thr Gly Ile Val Met Gly Gly Arg Ala Ile Leu Ala Ser Ser 
        195                 200                 205             
Thr Asn Lys Leu Arg Val Lys Arg Asp Tyr Ser Val Ser Val Val Ala 
    210                 215                 220                 
Lys Ala Ser Tyr Glu Gly Leu Thr Gly Gln Leu Ser Ala Glu Ala Lys 
225                 230                 235                 240 
Ala Lys Tyr Gly Glu Ser Ile Ser Ser Phe Thr Gln Tyr Ser Asn Thr 
                245                 250                 255     
His Gln Glu Val Arg Gly Gly Asp Gly Ala Lys Ala His Gly Val Phe 
            260                 265                 270         
Ser Gly Lys Lys Glu Asp Phe Gln Ala Trp Val Asp Ser Val Ser Ala 
        275                 280                 285             
Ser Pro Asp Phe Val Asp Phe Val Pro Thr Ile Pro Met Gln Glu Ile 
    290                 295                 300                 
Trp Thr Leu Cys Ser Ser Glu Ala Gln Ala Glu Ala Met Arg Lys His 
305                 310                 315                 320 
Tyr Asp Asp Val Trp Ala Pro Ala Gln Ser Glu Lys Tyr Arg Val Lys 
                325                 330                 335     
Ala Asn Tyr Leu Asp Gln Leu Val Val Leu Thr Gly Gly Ser Ser Thr 
            340                 345                 350         
Ile Glu Pro Pro Val Gly Tyr Ser Lys Leu Glu Tyr Asp Leu Asn Ala 
        355                 360                 365             
Gly Ala Gly Gly Asp Phe Ile Tyr Leu Cys Tyr His Glu Gln Thr Trp 
    370                 375                 380                 
Gln Ala Asp Arg Pro Lys Asp Ala Val Thr Asp Ile Arg Ile Ile Phe 
385                 390                 395                 400 
Asn Lys Glu Pro Thr Pro Pro Gly Tyr Thr Lys Leu Pro Gln Asp Leu 
                405                 410                 415     
Asn Lys Gly Ala Gly Gly Asp Asp Val Phe Leu Cys Tyr Lys Thr Glu 
            420                 425                 430         
Ala Phe Asn Thr Asp Thr Ala Ile Asn Lys Val Thr Val Ile Gly Gly 
        435                 440                 445             
Asn Asn Ala Asp Ile Asn Ala Pro Tyr Gly Tyr Leu Lys Val Pro Gly 
    450                 455                 460                 
Asp Leu Asn Arg Gly Ala Gly Gly Asn Phe Ile Tyr Ala Cys Thr Phe 
465                 470                 475                 480 
Val Gly Lys 
            

<210>  304
<211>  483
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  304
Met Glu Asn Ile Asp Leu Pro Gln Gly Leu Val Asn Phe Ser Thr Gln 
1               5                   10                  15      
His Leu Gln Leu Ile Arg Phe Lys Ala Gly Leu Asn Glu Thr Val Leu 
            20                  25                  30          
Pro Gly Val Glu Ala Ile Gly Leu Gly Tyr Asn Pro Phe Ile Ser Tyr 
        35                  40                  45              
Ala Ser Val Asn Ser Gly Ala Val Gln Leu Phe Asp Trp Ala Thr Ala 
    50                  55                  60                  
Lys Lys Arg Glu Val Pro Phe Lys Ala Gly Tyr Phe Val Pro Glu Leu 
65                  70                  75                  80  
Val Asp Val Gln Gln Asn Asp Ser Ala Thr Tyr Thr Asn Val Ser Gly 
                85                  90                  95      
Asn Thr Leu Ser Glu Tyr Gln Arg Ser Leu Ala Thr Ser Val Ala Ile 
            100                 105                 110         
Glu Gly Arg Tyr Asn Phe Phe Ser Gly Ser Leu Ser Thr Asp Phe Asp 
        115                 120                 125             
Ser Asn Ser Leu Arg Asn Ala Glu Asn Glu Phe Thr Arg Ile Gln Gln 
    130                 135                 140                 
Ser Ile Asn Leu Trp Ser Leu Arg Leu Pro Ser Val Lys Ser Leu Arg 
145                 150                 155                 160 
Glu Leu Met Leu Pro His Met Arg Gln Gln Leu Asp Glu Leu Asn Val 
                165                 170                 175     
Asn Asp Pro Lys Ala Ile Ser Arg Tyr Phe Asp Arg Val Gly Ser His 
            180                 185                 190         
Phe Leu Thr Gly Ile Val Met Gly Gly Arg Ala Ile Leu Ala Ser Ser 
        195                 200                 205             
Thr Asn Lys Leu Arg Val Lys Arg Asp Tyr Ser Val Ser Val Val Ala 
    210                 215                 220                 
Lys Ala Ser Tyr Glu Gly Leu Thr Gly Gln Leu Ser Ala Glu Ala Lys 
225                 230                 235                 240 
Ala Lys Tyr Gly Glu Ser Ile Ser Ser Phe Thr Gln Tyr Ser Asn Thr 
                245                 250                 255     
His Gln Glu Val Arg Gly Gly Asp Gly Ala Lys Ala His Gly Val Phe 
            260                 265                 270         
Ser Gly Lys Lys Glu Asp Phe Gln Ala Trp Val Asp Ser Val Ser Ala 
        275                 280                 285             
Ser Pro Asp Phe Val Asp Phe Val Pro Thr Ile Pro Met Gln Glu Ile 
    290                 295                 300                 
Trp Thr Leu Cys Ser Ser Glu Ala Gln Ala Glu Ala Met Arg Lys His 
305                 310                 315                 320 
Tyr Asp Asp Val Trp Ala Pro Ala Gln Ser Glu Lys Phe Arg Val Lys 
                325                 330                 335     
Ala Asn Tyr Ile Asp Gln Leu Val Val Ile Thr Gly Gly Ser Ser Thr 
            340                 345                 350         
Leu Glu Pro Pro Val Gly Tyr Ser Lys Ile Glu Tyr Asp Leu Asn Ala 
        355                 360                 365             
Gly Ala Gly Gly Asp Phe Ile Tyr Leu Cys Tyr His Glu Gln Thr Trp 
    370                 375                 380                 
Gln Ala Asp Arg Pro Lys Asp Ala Val Thr Asp Ile Arg Ile Ile Phe 
385                 390                 395                 400 
Asn Lys Glu Pro Thr Pro Pro Gly Tyr Thr Lys Leu Pro Gln Asp Leu 
                405                 410                 415     
Asn Lys Gly Ala Gly Gly Asp Asp Val Phe Leu Cys Tyr Lys Thr Glu 
            420                 425                 430         
Ala Tyr Asn Thr Asp Thr Ala Ile Asn Lys Val Thr Val Ile Gly Gly 
        435                 440                 445             
Asn Asn Ala Asp Ile Asn Ala Pro Tyr Gly Tyr Leu Lys Val Pro Gly 
    450                 455                 460                 
Asp Leu Asn Arg Gly Ala Gly Gly Asn Phe Ile Tyr Ala Cys Thr Phe 
465                 470                 475                 480 
Val Gly Lys 
            

<210>  305
<211>  483
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  305
Met Glu Asn Ile Asp Leu Pro Gln Gly Leu Val Asn Phe Ser Thr Gln 
1               5                   10                  15      
His Leu Gln Leu Ile Arg Phe Lys Ala Gly Leu Asn Glu Thr Val Leu 
            20                  25                  30          
Pro Gly Val Glu Ala Ile Gly Leu Gly Tyr Asn Pro Phe Ile Ser Tyr 
        35                  40                  45              
Ala Ser Val Asn Ser Gly Ala Val Gln Leu Phe Asp Trp Ala Thr Ala 
    50                  55                  60                  
Lys Lys Arg Glu Val Pro Phe Lys Ala Gly Tyr Phe Val Pro Glu Leu 
65                  70                  75                  80  
Val Asp Val Gln Gln Asn Asp Ser Ala Thr Tyr Thr Asn Val Ser Gly 
                85                  90                  95      
Asn Thr Leu Ser Glu Tyr Gln Arg Ser Leu Ala Thr Ser Val Ala Ile 
            100                 105                 110         
Glu Gly Arg Tyr Asn Phe Phe Ser Gly Ser Leu Ser Thr Asp Phe Asp 
        115                 120                 125             
Ser Asn Ser Leu Arg Asn Ala Glu Asn Glu Phe Thr Arg Ile Gln Gln 
    130                 135                 140                 
Ser Ile Asn Leu Trp Ser Leu Arg Leu Pro Ser Val Lys Ser Leu Arg 
145                 150                 155                 160 
Glu Leu Met Leu Pro His Met Arg Gln Gln Leu Asp Glu Leu Asn Val 
                165                 170                 175     
Asn Asp Pro Lys Ala Ile Ser Arg Tyr Phe Asp Arg Val Gly Ser His 
            180                 185                 190         
Phe Leu Thr Gly Ile Val Met Gly Gly Arg Ala Ile Leu Ala Ser Ser 
        195                 200                 205             
Thr Asn Lys Leu Arg Val Lys Arg Asp Tyr Ser Val Ser Val Val Ala 
    210                 215                 220                 
Lys Ala Ser Tyr Glu Gly Leu Thr Gly Gln Leu Ser Ala Glu Ala Lys 
225                 230                 235                 240 
Ala Lys Tyr Gly Glu Ser Ile Ser Ser Phe Thr Gln Tyr Ser Asn Thr 
                245                 250                 255     
His Gln Glu Val Arg Gly Gly Asp Gly Ala Lys Ala His Gly Val Phe 
            260                 265                 270         
Ser Gly Lys Lys Glu Asp Phe Gln Ala Trp Val Asp Ser Val Ser Ala 
        275                 280                 285             
Ser Pro Asp Phe Val Asp Phe Val Pro Thr Ile Pro Met Gln Glu Ile 
    290                 295                 300                 
Trp Thr Leu Cys Ser Ser Glu Ala Gln Ala Glu Ala Met Arg Lys His 
305                 310                 315                 320 
Tyr Asp Asp Val Trp Ala Pro Ala Gln Ser Glu Lys Tyr Arg Val Lys 
                325                 330                 335     
Ala Asn Tyr Ile Asp Gln Leu Val Val Leu Thr Gly Gly Ser Ser Thr 
            340                 345                 350         
Ile Glu Pro Pro Val Gly Tyr Ser Lys Leu Glu Tyr Asp Leu Asn Ala 
        355                 360                 365             
Gly Ala Gly Gly Asp Phe Ile Tyr Leu Cys Tyr His Glu Gln Thr Trp 
    370                 375                 380                 
Gln Ala Asp Arg Pro Lys Asp Ala Val Thr Asp Ile Arg Ile Ile Phe 
385                 390                 395                 400 
Asn Lys Glu Pro Thr Pro Pro Gly Tyr Thr Lys Leu Pro Gln Asp Leu 
                405                 410                 415     
Asn Lys Gly Ala Gly Gly Asp Asp Val Phe Leu Cys Tyr Lys Thr Glu 
            420                 425                 430         
Ala Tyr Asn Thr Asp Thr Ala Leu Asn Lys Val Thr Val Ile Gly Gly 
        435                 440                 445             
Asn Asn Ala Asp Ile Asn Ala Pro Tyr Gly Tyr Leu Lys Val Pro Gly 
    450                 455                 460                 
Asp Leu Asn Arg Gly Ala Gly Gly Asn Phe Ile Tyr Ala Cys Thr Phe 
465                 470                 475                 480 
Val Gly Lys 
            

<210>  306
<211>  392
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  306
Met Glu Asn Ile Asp Leu Pro Gln Gly Leu Val Asn Phe Ser Thr Gln 
1               5                   10                  15      
His Leu Gln Leu Ile Arg Phe Lys Ala Gly Leu Asn Glu Thr Val Leu 
            20                  25                  30          
Pro Gly Val Glu Ala Ile Gly Leu Gly Tyr Asn Pro Phe Ile Ser Tyr 
        35                  40                  45              
Ala Ser Val Asn Ser Gly Ala Val Gln Leu Phe Asp Trp Ala Thr Ala 
    50                  55                  60                  
Lys Lys Arg Glu Val Pro Phe Lys Ala Gly Tyr Phe Val Pro Glu Leu 
65                  70                  75                  80  
Val Asp Val Gln Gln Asn Asp Ser Ala Thr Phe Thr Asn Val Ser Gly 
                85                  90                  95      
Asn Thr Leu Ser Glu Tyr Gln Arg Ser Leu Ala Thr Ser Val Ala Ile 
            100                 105                 110         
Glu Gly Arg Tyr Asn Phe Phe Ser Gly Ser Leu Ser Thr Asp Phe Asp 
        115                 120                 125             
Ser Asn Ser Leu Arg Asn Ala Glu Asn Glu Phe Thr Arg Ile Gln Gln 
    130                 135                 140                 
Ser Ile Asn Leu Trp Ser Leu Arg Leu Pro Ser Val Lys Ser Leu Arg 
145                 150                 155                 160 
Glu Leu Met Leu Pro His Met Arg Gln Gln Leu Asp Glu Leu Asn Val 
                165                 170                 175     
Asn Asp Pro Lys Ala Ile Ser Arg Tyr Phe Asp Arg Val Gly Ser His 
            180                 185                 190         
Phe Leu Thr Gly Ile Val Met Gly Gly Arg Ala Ile Leu Ala Ser Ser 
        195                 200                 205             
Thr Asn Lys Leu Arg Val Lys Arg Asp Tyr Ser Val Ser Val Val Ala 
    210                 215                 220                 
Lys Ala Ser Tyr Glu Gly Leu Thr Gly Gln Leu Ser Ala Glu Ala Lys 
225                 230                 235                 240 
Ala Lys Tyr Gly Glu Ser Ile Ser Ser Phe Thr Gln Tyr Ser Asn Thr 
                245                 250                 255     
His Gln Glu Val Arg Gly Gly Asp Gly Ala Lys Ala His Gly Val Phe 
            260                 265                 270         
Ser Gly Lys Lys Glu Asp Phe Gln Ala Trp Val Asp Ser Val Ser Ala 
        275                 280                 285             
Ser Pro Asp Phe Val Asp Phe Val Pro Thr Ile Pro Met Gln Glu Ile 
    290                 295                 300                 
Trp Thr Leu Cys Ser Ser Glu Ala Gln Ala Glu Ala Met Arg Lys His 
305                 310                 315                 320 
Phe Asp Asp Val Trp Ala Pro Ala Gln Ser Glu Lys Phe Arg Val Lys 
                325                 330                 335     
Ala Asn Tyr Leu Asp Gln Leu Val Val Ile Thr Gly Gly Ile Gln Pro 
            340                 345                 350         
Ser Asn His Arg Ser Ala Thr Ala Arg Ser Ser Thr Thr Ser Met Pro 
        355                 360                 365             
Val Pro Ala Val Thr Ser Ser Thr Cys Ala Ile Thr Asn Lys Pro Gly 
    370                 375                 380                 
Arg Pro Thr Gly Leu Lys Met Leu 
385                 390         

<210>  307
<211>  459
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  307
Met Glu Asn Ile Asp Leu Pro Gln Gly Leu Val Asn Phe Ser Thr Gln 
1               5                   10                  15      
His Leu Gln Leu Ile Arg Phe Lys Ala Gly Leu Asn Glu Thr Val Leu 
            20                  25                  30          
Pro Gly Val Glu Ala Ile Gly Leu Gly Tyr Asn Pro Phe Ile Ser Tyr 
        35                  40                  45              
Ala Ser Val Asn Ser Gly Ala Val Gln Leu Phe Asp Trp Ala Thr Ala 
    50                  55                  60                  
Lys Lys Arg Glu Val Pro Phe Lys Ala Gly Tyr Phe Val Pro Glu Leu 
65                  70                  75                  80  
Val Asp Val Gln Gln Asn Asp Ser Ala Thr Tyr Thr Asn Val Ser Gly 
                85                  90                  95      
Asn Thr Ile Ser Glu Tyr Gln Arg Ser Leu Ala Thr Ser Val Ala Ile 
            100                 105                 110         
Glu Gly Arg Tyr Asn Phe Phe Ser Gly Ser Leu Ser Thr Asp Phe Asp 
        115                 120                 125             
Ser Asn Ser Leu Arg Asn Ala Glu Asn Glu Phe Thr Arg Ile Gln Gln 
    130                 135                 140                 
Ser Ile Asn Leu Trp Ser Leu Arg Leu Pro Ser Val Lys Ser Leu Arg 
145                 150                 155                 160 
Glu Leu Met Leu Pro His Met Arg Gln Gln Leu Asp Glu Leu Asn Val 
                165                 170                 175     
Asn Asp Pro Lys Ala Ile Ser Arg Tyr Phe Asp Arg Val Gly Ser His 
            180                 185                 190         
Phe Leu Thr Gly Ile Val Met Gly Gly Arg Ala Ile Leu Ala Ser Ser 
        195                 200                 205             
Thr Asn Lys Leu Arg Val Lys Arg Asp Tyr Ser Val Ser Val Val Ala 
    210                 215                 220                 
Lys Ala Ser Tyr Glu Gly Leu Thr Gly Gln Leu Ser Ala Glu Ala Lys 
225                 230                 235                 240 
Ala Lys Tyr Gly Glu Ser Ile Ser Ser Phe Thr Gln Tyr Ser Asn Thr 
                245                 250                 255     
His Gln Glu Val Arg Gly Gly Asp Gly Ala Lys Ala His Gly Val Phe 
            260                 265                 270         
Ser Gly Lys Lys Glu Asp Phe Gln Ala Trp Val Asp Ser Val Ser Ala 
        275                 280                 285             
Ser Pro Asp Phe Val Asp Phe Val Pro Thr Ile Pro Met Gln Glu Ile 
    290                 295                 300                 
Trp Thr Leu Cys Ser Ser Glu Ala Gln Ala Glu Ala Met Arg Lys His 
305                 310                 315                 320 
Tyr Asp Asp Val Trp Ala Pro Ala Gln Ser Glu Lys Tyr Arg Val Lys 
                325                 330                 335     
Ala Asn Tyr Leu Asp Gln Leu Val Val Ile Thr Gly Gly Ser Ser Thr 
            340                 345                 350         
Ile Glu Pro Pro Val Gly Tyr Ser Lys Leu Glu Tyr Asp Leu Asn Ala 
        355                 360                 365             
Gly Ala Gly Gly Asp Phe Ile Tyr Leu Cys Tyr His Glu Gln Thr Trp 
    370                 375                 380                 
Gln Ala Asp Arg Pro Lys Asp Ala Val Thr Asp Ile Arg Ile Ile Phe 
385                 390                 395                 400 
Asn Lys Glu Pro Thr Pro Pro Gly Tyr Thr Lys Leu Pro Gln Asp Leu 
                405                 410                 415     
Asn Lys Gly Ala Gly Gly Asp Asp Val Phe Leu Cys Tyr Lys Thr Glu 
            420                 425                 430         
Ala Tyr Asn Thr Ala Pro His Ser Thr Arg Ser Arg Ser Ser Ala Ala 
        435                 440                 445             
Thr Met Arg Ile Ser Thr Leu Pro Leu Val Ile 
    450                 455                 

<210>  308
<211>  483
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  308
Met Glu Asn Ile Asp Leu Pro Gln Gly Leu Val Asn Phe Ser Thr Gln 
1               5                   10                  15      
His Leu Gln Leu Ile Arg Phe Lys Ala Gly Leu Asn Glu Thr Val Leu 
            20                  25                  30          
Pro Gly Val Glu Ala Ile Gly Leu Gly Tyr Asn Pro Phe Ile Ser Tyr 
        35                  40                  45              
Ala Ser Val Asn Ser Gly Ala Val Gln Leu Phe Asp Trp Ala Thr Ala 
    50                  55                  60                  
Lys Lys Arg Glu Val Pro Phe Lys Ala Gly Tyr Phe Val Pro Glu Ile 
65                  70                  75                  80  
Val Asp Val Gln Gln Asn Asp Ser Ala Thr Tyr Thr Asn Val Ser Gly 
                85                  90                  95      
Asn Thr Ile Ser Glu Tyr Gln Arg Ser Leu Ala Thr Ser Val Ala Ile 
            100                 105                 110         
Glu Gly Arg Tyr Asn Phe Phe Ser Gly Ser Leu Ser Thr Asp Phe Asp 
        115                 120                 125             
Ser Asn Ser Leu Arg Asn Ala Glu Asn Glu Phe Thr Arg Ile Gln Gln 
    130                 135                 140                 
Ser Ile Asn Leu Trp Ser Leu Arg Leu Pro Ser Val Lys Ser Leu Arg 
145                 150                 155                 160 
Glu Leu Met Leu Pro His Met Arg Gln Gln Leu Asp Glu Leu Asn Val 
                165                 170                 175     
Asn Asp Pro Lys Ala Ile Ser Arg Tyr Phe Asp Arg Val Gly Ser His 
            180                 185                 190         
Phe Leu Thr Gly Ile Val Met Gly Gly Arg Ala Ile Leu Ala Ser Ser 
        195                 200                 205             
Thr Asn Lys Leu Arg Val Lys Arg Asp Tyr Ser Val Ser Val Val Ala 
    210                 215                 220                 
Lys Ala Ser Tyr Glu Gly Leu Thr Gly Gln Leu Ser Ala Glu Ala Lys 
225                 230                 235                 240 
Ala Lys Tyr Gly Glu Ser Ile Ser Ser Phe Thr Gln Tyr Ser Asn Thr 
                245                 250                 255     
His Gln Glu Val Arg Gly Gly Asp Gly Ala Lys Ala His Gly Val Phe 
            260                 265                 270         
Ser Gly Lys Lys Glu Asp Phe Gln Ala Trp Val Asp Ser Val Ser Ala 
        275                 280                 285             
Ser Pro Asp Phe Val Asp Phe Val Pro Thr Ile Pro Met Gln Glu Ile 
    290                 295                 300                 
Trp Thr Leu Cys Ser Ser Glu Ala Gln Ala Glu Ala Met Arg Lys His 
305                 310                 315                 320 
Tyr Asp Asp Val Trp Ala Pro Ala Gln Ser Glu Lys Phe Arg Val Lys 
                325                 330                 335     
Ala Asn Tyr Leu Asp Gln Leu Val Val Ile Thr Gly Gly Ser Ser Thr 
            340                 345                 350         
Ile Glu Pro Pro Val Gly Tyr Ser Lys Leu Glu Tyr Asp Leu Asn Ala 
        355                 360                 365             
Gly Ala Gly Gly Asp Phe Ile Tyr Leu Cys Tyr His Glu Gln Thr Trp 
    370                 375                 380                 
Gln Ala Asp Arg Pro Lys Asp Ala Val Thr Asp Ile Arg Ile Ile Phe 
385                 390                 395                 400 
Asn Lys Glu Pro Thr Pro Pro Gly Tyr Thr Lys Leu Pro Gln Asp Leu 
                405                 410                 415     
Asn Lys Gly Ala Gly Gly Asp Asp Val Phe Leu Cys Tyr Lys Thr Glu 
            420                 425                 430         
Ala Tyr Asn Thr Asp Thr Ala Ile Asn Lys Val Thr Val Ile Gly Gly 
        435                 440                 445             
Asn Asn Ala Asp Ile Asn Ala Pro Tyr Gly Tyr Leu Lys Val Pro Gly 
    450                 455                 460                 
Asp Leu Asn Arg Gly Ala Gly Gly Asn Phe Ile Tyr Ala Cys Thr Phe 
465                 470                 475                 480 
Val Gly Lys 
            

<210>  309
<211>  483
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  309
Met Glu Asn Ile Asp Leu Pro Gln Gly Leu Val Asn Phe Ser Thr Gln 
1               5                   10                  15      
His Leu Gln Leu Ile Arg Phe Lys Ala Gly Leu Asn Glu Thr Val Leu 
            20                  25                  30          
Pro Gly Val Glu Ala Ile Gly Leu Gly Tyr Asn Pro Phe Ile Ser Tyr 
        35                  40                  45              
Ala Ser Val Asn Ser Gly Ala Val Gln Leu Phe Asp Trp Ala Thr Ala 
    50                  55                  60                  
Lys Lys Arg Glu Val Pro Phe Lys Ala Gly Tyr Phe Val Pro Glu Leu 
65                  70                  75                  80  
Val Asp Val Gln Gln Asn Asp Ser Ala Thr Phe Thr Asn Val Ser Gly 
                85                  90                  95      
Asn Thr Ile Ser Glu Tyr Gln Arg Ser Leu Ala Thr Ser Val Ala Ile 
            100                 105                 110         
Glu Gly Arg Tyr Asn Phe Phe Ser Gly Ser Leu Ser Thr Asp Phe Asp 
        115                 120                 125             
Ser Asn Ser Leu Arg Asn Ala Glu Asn Glu Phe Thr Arg Ile Gln Gln 
    130                 135                 140                 
Ser Ile Asn Leu Trp Ser Leu Arg Leu Pro Ser Val Lys Ser Leu Arg 
145                 150                 155                 160 
Glu Leu Met Leu Pro His Met Arg Gln Gln Leu Asp Glu Leu Asn Val 
                165                 170                 175     
Asn Asp Pro Lys Ala Ile Ser Arg Tyr Phe Asp Arg Val Gly Ser His 
            180                 185                 190         
Phe Leu Thr Gly Ile Val Met Gly Gly Arg Ala Ile Leu Ala Ser Ser 
        195                 200                 205             
Thr Asn Lys Leu Arg Val Lys Arg Asp Tyr Ser Val Ser Val Val Ala 
    210                 215                 220                 
Lys Ala Ser Tyr Glu Gly Leu Thr Gly Gln Leu Ser Ala Glu Ala Lys 
225                 230                 235                 240 
Ala Lys Tyr Gly Glu Ser Ile Ser Ser Phe Thr Gln Tyr Ser Asn Thr 
                245                 250                 255     
His Gln Glu Val Arg Gly Gly Asp Gly Ala Lys Ala His Gly Val Phe 
            260                 265                 270         
Ser Gly Lys Lys Glu Asp Phe Gln Ala Trp Val Asp Ser Val Ser Ala 
        275                 280                 285             
Ser Pro Asp Phe Val Asp Phe Val Pro Thr Ile Pro Met Gln Glu Ile 
    290                 295                 300                 
Trp Thr Leu Cys Ser Ser Glu Ala Gln Ala Glu Ala Met Arg Lys His 
305                 310                 315                 320 
Tyr Asp Asp Val Trp Ala Pro Ala Gln Ser Glu Lys Tyr Arg Val Lys 
                325                 330                 335     
Ala Asn Tyr Leu Asp Gln Leu Val Val Ile Thr Gly Gly Ser Ser Thr 
            340                 345                 350         
Ile Glu Pro Pro Val Gly Tyr Ser Lys Ile Glu Tyr Asp Leu Asn Ala 
        355                 360                 365             
Gly Ala Gly Gly Asp Phe Ile Tyr Leu Cys Tyr His Glu Gln Thr Trp 
    370                 375                 380                 
Gln Ala Asp Arg Pro Lys Asp Ala Val Thr Asp Ile Arg Ile Ile Phe 
385                 390                 395                 400 
Asn Lys Glu Pro Thr Pro Pro Gly Tyr Thr Lys Leu Pro Gln Asp Leu 
                405                 410                 415     
Asn Lys Gly Ala Gly Gly Asp Asp Val Phe Leu Cys Tyr Lys Thr Glu 
            420                 425                 430         
Ala Tyr Asn Thr Asp Thr Ala Ile Asn Lys Val Thr Val Ile Gly Gly 
        435                 440                 445             
Asn Asn Ala Asp Ile Asn Ala Pro Tyr Gly Tyr Leu Lys Val Pro Gly 
    450                 455                 460                 
Asp Leu Asn Arg Gly Ala Gly Gly Asn Phe Ile Tyr Ala Cys Thr Phe 
465                 470                 475                 480 
Val Gly Lys 
            

<210>  310
<211>  483
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  310
Met Glu Asn Ile Asp Leu Pro Gln Gly Leu Val Asn Phe Ser Thr Gln 
1               5                   10                  15      
His Leu Gln Leu Ile Arg Phe Lys Ala Gly Leu Asn Glu Thr Val Leu 
            20                  25                  30          
Pro Gly Val Glu Ala Ile Gly Leu Gly Tyr Asn Pro Phe Ile Ser Tyr 
        35                  40                  45              
Ala Ser Val Asn Ser Gly Ala Val Gln Leu Phe Asp Trp Ala Thr Ala 
    50                  55                  60                  
Lys Lys Arg Glu Val Pro Phe Lys Ala Gly Tyr Phe Val Pro Glu Ile 
65                  70                  75                  80  
Val Asp Val Gln Gln Asn Asp Ser Ala Thr Phe Thr Asn Val Ser Gly 
                85                  90                  95      
Asn Thr Ile Ser Glu Tyr Gln Arg Ser Leu Ala Thr Ser Val Ala Ile 
            100                 105                 110         
Glu Gly Arg Tyr Asn Phe Phe Ser Gly Ser Leu Ser Thr Asp Phe Asp 
        115                 120                 125             
Ser Asn Ser Leu Arg Asn Ala Glu Asn Glu Phe Thr Arg Ile Gln Gln 
    130                 135                 140                 
Ser Ile Asn Leu Trp Ser Leu Arg Leu Pro Ser Val Lys Ser Leu Arg 
145                 150                 155                 160 
Glu Leu Met Leu Pro His Met Arg Gln Gln Leu Asp Glu Leu Asn Val 
                165                 170                 175     
Asn Asp Pro Lys Ala Ile Ser Arg Tyr Phe Asp Arg Val Gly Ser His 
            180                 185                 190         
Phe Leu Thr Gly Ile Val Met Gly Gly Arg Ala Ile Leu Ala Ser Ser 
        195                 200                 205             
Thr Asn Lys Leu Arg Val Lys Arg Asp Tyr Ser Val Ser Val Val Ala 
    210                 215                 220                 
Lys Ala Ser Tyr Glu Gly Leu Thr Gly Gln Leu Ser Ala Glu Ala Lys 
225                 230                 235                 240 
Ala Lys Tyr Gly Glu Ser Ile Ser Ser Phe Thr Gln Tyr Ser Asn Thr 
                245                 250                 255     
His Gln Glu Val Arg Gly Gly Asp Gly Ala Lys Ala His Gly Val Phe 
            260                 265                 270         
Ser Gly Lys Lys Glu Asp Phe Gln Ala Trp Val Asp Ser Val Ser Ala 
        275                 280                 285             
Ser Pro Asp Phe Val Asp Phe Val Pro Thr Ile Pro Met Gln Glu Ile 
    290                 295                 300                 
Trp Thr Leu Cys Ser Ser Glu Ala Gln Ala Glu Ala Met Arg Lys His 
305                 310                 315                 320 
Tyr Asp Asp Val Trp Ala Pro Ala Gln Ser Glu Lys Phe Arg Val Lys 
                325                 330                 335     
Ala Asn Tyr Ile Asp Gln Leu Val Val Ile Thr Gly Gly Ser Ser Thr 
            340                 345                 350         
Ile Glu Pro Pro Val Gly Tyr Ser Lys Ile Glu Tyr Asp Leu Asn Ala 
        355                 360                 365             
Gly Ala Gly Gly Asp Phe Ile Tyr Leu Cys Tyr His Glu Gln Thr Trp 
    370                 375                 380                 
Gln Ala Asp Arg Pro Lys Asp Ala Val Thr Asp Ile Arg Ile Ile Phe 
385                 390                 395                 400 
Asn Lys Glu Pro Thr Pro Pro Gly Tyr Thr Lys Leu Pro Gln Asp Leu 
                405                 410                 415     
Asn Lys Gly Ala Gly Gly Asp Asp Val Phe Leu Cys Tyr Lys Thr Glu 
            420                 425                 430         
Ala Tyr Asn Thr Asp Thr Ala Ile Asn Lys Val Thr Val Leu Gly Gly 
        435                 440                 445             
Asn Asn Ala Asp Ile Asn Ala Pro Tyr Gly Tyr Leu Lys Val Pro Gly 
    450                 455                 460                 
Asp Leu Asn Arg Gly Ala Gly Gly Asn Phe Ile Tyr Ala Cys Thr Phe 
465                 470                 475                 480 
Val Gly Lys 
            

<210>  311
<211>  483
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  311
Met Glu Asn Ile Asp Leu Pro Gln Gly Leu Val Asn Phe Ser Thr Gln 
1               5                   10                  15      
His Leu Gln Leu Ile Arg Phe Lys Ala Gly Leu Asn Glu Thr Val Leu 
            20                  25                  30          
Pro Gly Val Glu Ala Ile Gly Leu Gly Tyr Asn Pro Phe Ile Ser Tyr 
        35                  40                  45              
Ala Ser Val Asn Ser Gly Ala Val Gln Leu Phe Asp Trp Ala Thr Ala 
    50                  55                  60                  
Lys Lys Arg Glu Val Pro Phe Lys Ala Gly Tyr Phe Val Pro Glu Leu 
65                  70                  75                  80  
Val Asp Val Gln Gln Asn Asp Ser Ala Thr Phe Thr Asn Val Ser Gly 
                85                  90                  95      
Asn Thr Ile Ser Glu Tyr Gln Arg Ser Leu Ala Thr Ser Val Ala Ile 
            100                 105                 110         
Glu Gly Arg Tyr Asn Phe Phe Ser Gly Ser Leu Ser Thr Asp Phe Asp 
        115                 120                 125             
Ser Asn Ser Leu Arg Asn Ala Glu Asn Glu Phe Thr Arg Ile Gln Gln 
    130                 135                 140                 
Ser Ile Asn Leu Trp Ser Leu Arg Leu Pro Ser Val Lys Ser Leu Arg 
145                 150                 155                 160 
Glu Leu Met Leu Pro His Met Arg Gln Gln Leu Asp Glu Leu Asn Val 
                165                 170                 175     
Asn Asp Pro Lys Ala Ile Ser Arg Tyr Phe Asp Arg Val Gly Ser His 
            180                 185                 190         
Phe Leu Thr Gly Ile Val Met Gly Gly Arg Ala Ile Leu Ala Ser Ser 
        195                 200                 205             
Thr Asn Lys Leu Arg Val Lys Arg Asp Tyr Ser Val Ser Val Val Ala 
    210                 215                 220                 
Lys Ala Ser Tyr Glu Gly Leu Thr Gly Gln Leu Ser Ala Glu Ala Lys 
225                 230                 235                 240 
Ala Lys Tyr Gly Glu Ser Ile Ser Ser Phe Thr Gln Tyr Ser Asn Thr 
                245                 250                 255     
His Gln Glu Val Arg Gly Gly Asp Gly Ala Lys Ala His Gly Val Phe 
            260                 265                 270         
Ser Gly Lys Lys Glu Asp Phe Gln Ala Trp Val Asp Ser Val Ser Ala 
        275                 280                 285             
Ser Pro Asp Phe Val Asp Phe Val Pro Thr Ile Pro Met Gln Glu Ile 
    290                 295                 300                 
Trp Thr Leu Cys Ser Ser Glu Ala Gln Ala Glu Ala Met Arg Lys His 
305                 310                 315                 320 
Tyr Asp Asp Val Trp Ala Pro Ala Gln Ser Glu Lys Phe Arg Val Lys 
                325                 330                 335     
Ala Asn Tyr Ile Asp Gln Leu Val Val Ile Thr Gly Gly Ser Ser Thr 
            340                 345                 350         
Ile Glu Pro Pro Val Gly Tyr Ser Lys Ile Glu Tyr Asp Leu Asn Ala 
        355                 360                 365             
Gly Ala Gly Gly Asp Phe Ile Tyr Leu Cys Tyr His Glu Gln Thr Trp 
    370                 375                 380                 
Gln Ala Asp Arg Pro Lys Asp Ala Val Thr Asp Ile Arg Ile Ile Phe 
385                 390                 395                 400 
Asn Lys Glu Pro Thr Pro Pro Gly Tyr Thr Lys Leu Pro Gln Asp Leu 
                405                 410                 415     
Asn Lys Gly Ala Gly Gly Asp Asp Val Phe Leu Cys Tyr Lys Thr Glu 
            420                 425                 430         
Ala Phe Asn Thr Asp Thr Ala Ile Asn Lys Val Thr Val Ile Gly Gly 
        435                 440                 445             
Asn Asn Ala Asp Ile Asn Ala Pro Tyr Gly Tyr Leu Lys Val Pro Gly 
    450                 455                 460                 
Asp Leu Asn Arg Gly Ala Gly Gly Asn Phe Ile Tyr Ala Cys Thr Phe 
465                 470                 475                 480 
Val Gly Lys 
            

<210>  312
<211>  483
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  312
Met Glu Asn Ile Asp Leu Pro Gln Gly Leu Val Asn Phe Ser Thr Gln 
1               5                   10                  15      
His Leu Gln Leu Ile Arg Phe Lys Ala Gly Leu Asn Glu Thr Val Leu 
            20                  25                  30          
Pro Gly Val Glu Ala Ile Gly Leu Gly Tyr Asn Pro Phe Ile Ser Tyr 
        35                  40                  45              
Ala Ser Val Asn Ser Gly Ala Val Gln Leu Phe Asp Trp Ala Thr Ala 
    50                  55                  60                  
Lys Lys Arg Glu Val Pro Phe Lys Ala Gly Tyr Phe Val Pro Glu Ile 
65                  70                  75                  80  
Val Asp Val Gln Gln Asn Asp Ser Ala Thr Phe Thr Asn Val Ser Gly 
                85                  90                  95      
Asn Thr Ile Ser Glu Tyr Gln Arg Ser Leu Ala Thr Ser Val Ala Ile 
            100                 105                 110         
Glu Gly Arg Tyr Asn Phe Phe Ser Gly Ser Leu Ser Thr Asp Phe Asp 
        115                 120                 125             
Ser Asn Ser Leu Arg Asn Ala Glu Asn Glu Phe Thr Arg Ile Gln Gln 
    130                 135                 140                 
Ser Ile Asn Leu Trp Ser Leu Arg Leu Pro Ser Val Lys Ser Leu Arg 
145                 150                 155                 160 
Glu Leu Met Leu Pro His Met Arg Gln Gln Leu Asp Glu Leu Asn Val 
                165                 170                 175     
Asn Asp Pro Lys Ala Ile Ser Arg Tyr Phe Asp Arg Val Gly Ser His 
            180                 185                 190         
Phe Leu Thr Gly Ile Val Met Gly Gly Arg Ala Ile Leu Ala Ser Ser 
        195                 200                 205             
Thr Asn Lys Leu Arg Val Lys Arg Asp Tyr Ser Val Ser Val Val Ala 
    210                 215                 220                 
Lys Ala Ser Tyr Glu Gly Leu Thr Gly Gln Leu Ser Ala Glu Ala Lys 
225                 230                 235                 240 
Ala Lys Tyr Gly Glu Ser Ile Ser Ser Phe Thr Gln Tyr Ser Asn Thr 
                245                 250                 255     
His Gln Glu Val Arg Gly Gly Asp Gly Ala Lys Ala His Gly Val Phe 
            260                 265                 270         
Ser Gly Lys Lys Glu Asp Phe Gln Ala Trp Val Asp Ser Val Ser Ala 
        275                 280                 285             
Ser Pro Asp Phe Val Asp Phe Val Pro Thr Ile Pro Met Gln Glu Ile 
    290                 295                 300                 
Trp Thr Leu Cys Ser Ser Glu Ala Gln Ala Glu Ala Met Arg Lys His 
305                 310                 315                 320 
Tyr Asp Asp Val Trp Ala Pro Ala Gln Ser Glu Lys Phe Arg Val Lys 
                325                 330                 335     
Ala Asn Tyr Ile Asp Gln Leu Val Val Ile Thr Gly Gly Ser Ser Thr 
            340                 345                 350         
Ile Glu Pro Pro Val Gly Tyr Ser Lys Ile Glu Tyr Asp Leu Asn Ala 
        355                 360                 365             
Gly Ala Gly Gly Asp Phe Ile Tyr Leu Cys Tyr His Glu Gln Thr Trp 
    370                 375                 380                 
Gln Ala Asp Arg Pro Lys Asp Ala Val Thr Asp Ile Arg Ile Ile Phe 
385                 390                 395                 400 
Asn Lys Glu Pro Thr Pro Pro Gly Tyr Thr Lys Leu Pro Gln Asp Leu 
                405                 410                 415     
Asn Lys Gly Ala Gly Gly Asp Asp Val Phe Leu Cys Tyr Lys Thr Glu 
            420                 425                 430         
Ala Tyr Asn Thr Asp Thr Ala Ile Asn Lys Val Thr Val Ile Gly Gly 
        435                 440                 445             
Asn Asn Ala Asp Ile Asn Ala Pro Tyr Gly Tyr Leu Lys Val Pro Gly 
    450                 455                 460                 
Asp Leu Asn Arg Gly Ala Gly Gly Asn Phe Ile Tyr Ala Cys Thr Phe 
465                 470                 475                 480 
Val Gly Lys 
            

<210>  313
<211>  483
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  313
Met Glu Asn Ile Asp Leu Pro Gln Gly Leu Val Asn Phe Ser Thr Gln 
1               5                   10                  15      
His Leu Gln Leu Ile Arg Phe Lys Ala Gly Leu Asn Glu Thr Val Leu 
            20                  25                  30          
Pro Gly Val Glu Ala Ile Gly Leu Gly Tyr Asn Pro Phe Ile Ser Tyr 
        35                  40                  45              
Ala Ser Val Asn Ser Gly Ala Val Gln Leu Phe Asp Trp Ala Thr Ala 
    50                  55                  60                  
Lys Lys Arg Glu Val Pro Phe Lys Ala Gly Tyr Phe Val Pro Glu Leu 
65                  70                  75                  80  
Val Asp Val Gln Gln Asn Asp Ser Ala Thr Phe Thr Asn Val Ser Gly 
                85                  90                  95      
Asn Thr Leu Ser Glu Tyr Gln Arg Ser Leu Ala Thr Ser Val Ala Ile 
            100                 105                 110         
Glu Gly Arg Tyr Asn Phe Phe Ser Gly Ser Leu Ser Thr Asp Phe Asp 
        115                 120                 125             
Ser Asn Ser Leu Arg Asn Ala Glu Asn Glu Phe Thr Arg Ile Gln Gln 
    130                 135                 140                 
Ser Ile Asn Leu Trp Ser Leu Arg Leu Pro Ser Val Lys Ser Leu Arg 
145                 150                 155                 160 
Glu Leu Met Leu Pro His Met Arg Gln Gln Leu Asp Glu Leu Asn Val 
                165                 170                 175     
Asn Asp Pro Lys Ala Ile Ser Arg Tyr Phe Asp Arg Val Gly Ser His 
            180                 185                 190         
Phe Leu Thr Gly Ile Val Met Gly Gly Arg Ala Ile Leu Ala Ser Ser 
        195                 200                 205             
Thr Asn Lys Leu Arg Val Lys Arg Asp Tyr Ser Val Ser Val Val Ala 
    210                 215                 220                 
Lys Ala Ser Tyr Glu Gly Leu Thr Gly Gln Leu Ser Ala Glu Ala Lys 
225                 230                 235                 240 
Ala Lys Tyr Gly Glu Ser Ile Ser Ser Phe Thr Gln Tyr Ser Asn Thr 
                245                 250                 255     
His Gln Glu Val Arg Gly Gly Asp Gly Ala Lys Ala His Gly Val Phe 
            260                 265                 270         
Ser Gly Lys Lys Glu Asp Phe Gln Ala Trp Val Asp Ser Val Ser Ala 
        275                 280                 285             
Ser Pro Asp Phe Val Asp Phe Val Pro Thr Ile Pro Met Gln Glu Ile 
    290                 295                 300                 
Trp Thr Leu Cys Ser Ser Glu Ala Gln Ala Glu Ala Met Arg Lys His 
305                 310                 315                 320 
Tyr Asp Asp Val Trp Ala Pro Ala Gln Ser Glu Lys Tyr Arg Val Lys 
                325                 330                 335     
Ala Asn Phe Ile Asp Gln Leu Val Val Leu Thr Gly Gly Ser Ser Thr 
            340                 345                 350         
Leu Glu Pro Pro Val Gly Tyr Ser Lys Ile Glu Tyr Asp Leu Asn Ala 
        355                 360                 365             
Gly Ala Gly Gly Asp Phe Ile Tyr Leu Cys Tyr His Glu Gln Thr Trp 
    370                 375                 380                 
Gln Ala Asp Arg Pro Lys Asp Ala Val Thr Asp Ile Arg Ile Ile Phe 
385                 390                 395                 400 
Asn Lys Glu Pro Thr Pro Pro Gly Tyr Thr Lys Leu Pro Gln Asp Leu 
                405                 410                 415     
Asn Lys Gly Ala Gly Gly Asp Asp Val Phe Leu Cys Tyr Lys Thr Glu 
            420                 425                 430         
Ala Phe Asn Thr Asp Thr Ala Leu Asn Lys Val Thr Val Ile Gly Gly 
        435                 440                 445             
Asn Asn Ala Asp Ile Asn Ala Pro Phe Gly Tyr Leu Lys Val Pro Gly 
    450                 455                 460                 
Asp Leu Asn Arg Gly Ala Gly Gly Asn Phe Ile Tyr Ala Cys Thr Phe 
465                 470                 475                 480 
Val Gly Lys 
            

<210>  314
<211>  392
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  314
Met Glu Asn Ile Asp Leu Pro Gln Gly Leu Val Asn Phe Ser Thr Gln 
1               5                   10                  15      
His Leu Gln Leu Ile Arg Phe Lys Ala Gly Leu Asn Glu Thr Val Leu 
            20                  25                  30          
Pro Gly Val Glu Ala Ile Gly Leu Gly Tyr Asn Pro Phe Ile Ser Tyr 
        35                  40                  45              
Ala Ser Val Asn Ser Gly Ala Val Gln Leu Phe Asp Trp Ala Thr Ala 
    50                  55                  60                  
Lys Lys Arg Glu Val Pro Phe Lys Ala Gly Tyr Phe Val Pro Glu Leu 
65                  70                  75                  80  
Val Asp Val Gln Gln Asn Asp Ser Ala Thr Phe Thr Asn Val Ser Gly 
                85                  90                  95      
Asn Thr Ile Ser Glu Tyr Gln Arg Ser Leu Ala Thr Ser Val Ala Ile 
            100                 105                 110         
Glu Gly Arg Tyr Asn Phe Phe Ser Gly Ser Leu Ser Thr Asp Phe Asp 
        115                 120                 125             
Ser Asn Ser Leu Arg Asn Ala Glu Asn Glu Phe Thr Arg Ile Gln Gln 
    130                 135                 140                 
Ser Ile Asn Leu Trp Ser Leu Arg Leu Pro Ser Val Lys Ser Leu Arg 
145                 150                 155                 160 
Glu Leu Met Leu Pro His Met Arg Gln Gln Leu Asp Glu Leu Asn Val 
                165                 170                 175     
Asn Asp Pro Lys Ala Ile Ser Arg Tyr Phe Asp Arg Val Gly Ser His 
            180                 185                 190         
Phe Leu Thr Gly Ile Val Met Gly Gly Arg Ala Ile Leu Ala Ser Ser 
        195                 200                 205             
Thr Asn Lys Leu Arg Val Lys Arg Asp Tyr Ser Val Ser Val Val Ala 
    210                 215                 220                 
Lys Ala Ser Tyr Glu Gly Leu Thr Gly Gln Leu Ser Ala Glu Ala Lys 
225                 230                 235                 240 
Ala Lys Tyr Gly Glu Ser Ile Ser Ser Phe Thr Gln Tyr Ser Asn Thr 
                245                 250                 255     
His Gln Glu Val Arg Gly Gly Asp Gly Ala Lys Ala His Gly Val Phe 
            260                 265                 270         
Ser Gly Lys Lys Glu Asp Phe Gln Ala Trp Val Asp Ser Val Ser Ala 
        275                 280                 285             
Ser Pro Asp Phe Val Asp Phe Val Pro Thr Ile Pro Met Gln Glu Ile 
    290                 295                 300                 
Trp Thr Leu Cys Ser Ser Glu Ala Gln Ala Glu Ala Met Arg Ser Ile 
305                 310                 315                 320 
Ser Met Thr Ser Gly Arg Arg Arg Asn Arg Lys Ser Ser Gly Ser Arg 
                325                 330                 335     
Leu Thr Thr Ser Thr Asn Trp Trp Ser Ser Pro Ala Val Val Gln Pro 
            340                 345                 350         
Ser Asn His Arg Ser Ala Thr Ala Ser Ser Ser Thr Thr Ser Met Pro 
        355                 360                 365             
Val Pro Ala Val Thr Ser Ser Thr Cys Ala Ile Thr Asn Lys Pro Gly 
    370                 375                 380                 
Arg Pro Thr Gly Leu Lys Met Leu 
385                 390         

<210>  315
<211>  483
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  315
Met Glu Asn Ile Asp Leu Pro Gln Gly Leu Val Asn Phe Ser Thr Gln 
1               5                   10                  15      
His Leu Gln Leu Ile Arg Phe Lys Ala Gly Leu Asn Glu Thr Val Leu 
            20                  25                  30          
Pro Gly Val Glu Ala Ile Gly Leu Gly Tyr Asn Pro Phe Ile Ser Tyr 
        35                  40                  45              
Ala Ser Val Asn Ser Gly Ala Val Gln Leu Phe Asp Trp Ala Thr Ala 
    50                  55                  60                  
Lys Lys Arg Glu Val Pro Phe Lys Ala Gly Tyr Phe Val Pro Glu Leu 
65                  70                  75                  80  
Val Asp Val Gln Gln Asn Asp Ser Ala Thr Tyr Thr Asn Val Ser Gly 
                85                  90                  95      
Asn Thr Leu Ser Glu Tyr Gln Arg Ser Leu Ala Thr Ser Val Ala Ile 
            100                 105                 110         
Glu Gly Arg Tyr Asn Phe Phe Ser Gly Ser Leu Ser Thr Asp Phe Asp 
        115                 120                 125             
Ser Asn Ser Leu Arg Asn Ala Glu Asn Glu Phe Thr Arg Ile Gln Gln 
    130                 135                 140                 
Ser Ile Asn Leu Trp Ser Leu Arg Leu Pro Ser Val Lys Ser Leu Arg 
145                 150                 155                 160 
Glu Leu Met Leu Pro His Met Arg Gln Gln Leu Asp Glu Leu Asn Val 
                165                 170                 175     
Asn Asp Pro Lys Ala Ile Ser Arg Tyr Phe Asp Arg Val Gly Ser His 
            180                 185                 190         
Phe Leu Thr Gly Ile Val Met Gly Gly Arg Ala Ile Leu Ala Ser Ser 
        195                 200                 205             
Thr Asn Lys Leu Arg Val Lys Arg Asp Tyr Ser Val Ser Val Val Ala 
    210                 215                 220                 
Lys Ala Ser Tyr Glu Gly Leu Thr Gly Gln Leu Ser Ala Glu Ala Lys 
225                 230                 235                 240 
Ala Lys Tyr Gly Glu Ser Ile Ser Ser Phe Thr Gln Tyr Ser Asn Thr 
                245                 250                 255     
His Gln Glu Val Arg Gly Gly Asp Gly Ala Lys Ala His Gly Val Phe 
            260                 265                 270         
Ser Gly Lys Lys Glu Asp Phe Gln Ala Trp Val Asp Ser Val Ser Ala 
        275                 280                 285             
Ser Pro Asp Phe Val Asp Phe Val Pro Thr Ile Pro Met Gln Glu Ile 
    290                 295                 300                 
Trp Thr Leu Cys Ser Ser Glu Ala Gln Ala Glu Ala Met Arg Lys His 
305                 310                 315                 320 
Tyr Asp Asp Val Trp Ala Pro Ala Gln Ser Glu Lys Tyr Arg Val Lys 
                325                 330                 335     
Ala Asn Tyr Ile Asp Gln Leu Val Val Leu Thr Gly Gly Ser Ser Thr 
            340                 345                 350         
Ile Glu Pro Pro Val Gly Tyr Ser Lys Ile Glu Tyr Asp Leu Asn Ala 
        355                 360                 365             
Gly Ala Gly Gly Asp Phe Ile Tyr Leu Cys Tyr His Glu Gln Thr Trp 
    370                 375                 380                 
Gln Ala Asp Arg Pro Lys Asp Ala Val Thr Asp Ile Arg Ile Ile Phe 
385                 390                 395                 400 
Asn Lys Glu Pro Thr Pro Pro Gly Tyr Thr Lys Leu Pro Gln Asp Leu 
                405                 410                 415     
Asn Lys Gly Ala Gly Gly Asp Asp Val Phe Leu Cys Tyr Lys Thr Glu 
            420                 425                 430         
Ala Tyr Asn Thr Asp Thr Ala Leu Asn Lys Val Thr Val Ile Gly Gly 
        435                 440                 445             
Asn Asn Ala Asp Ile Asn Ala Pro Tyr Gly Tyr Leu Lys Val Pro Gly 
    450                 455                 460                 
Asp Leu Asn Arg Gly Ala Gly Gly Asn Phe Ile Tyr Ala Cys Thr Phe 
465                 470                 475                 480 
Val Gly Lys 
            

<210>  316
<211>  483
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  316
Met Glu Asn Ile Asp Leu Pro Gln Gly Leu Val Asn Phe Ser Thr Gln 
1               5                   10                  15      
His Leu Gln Leu Ile Arg Phe Lys Ala Gly Leu Asn Glu Thr Val Leu 
            20                  25                  30          
Pro Gly Val Glu Ala Ile Gly Leu Gly Tyr Asn Pro Phe Ile Ser Tyr 
        35                  40                  45              
Ala Ser Val Asn Ser Gly Ala Val Gln Leu Phe Asp Trp Ala Thr Ala 
    50                  55                  60                  
Lys Lys Arg Glu Val Pro Phe Lys Ala Gly Tyr Phe Val Pro Glu Leu 
65                  70                  75                  80  
Val Asp Val Gln Gln Asn Asp Ser Ala Thr Phe Thr Asn Val Ser Gly 
                85                  90                  95      
Asn Thr Ile Ser Glu Tyr Gln Arg Ser Leu Ala Thr Ser Val Ala Ile 
            100                 105                 110         
Glu Gly Arg Tyr Asn Phe Phe Ser Gly Ser Leu Ser Thr Asp Phe Asp 
        115                 120                 125             
Ser Asn Ser Leu Arg Asn Ala Glu Asn Glu Phe Thr Arg Ile Gln Gln 
    130                 135                 140                 
Ser Ile Asn Leu Trp Ser Leu Arg Leu Pro Ser Val Lys Ser Leu Arg 
145                 150                 155                 160 
Glu Leu Met Leu Pro His Met Arg Gln Gln Leu Asp Glu Leu Asn Val 
                165                 170                 175     
Asn Asp Pro Lys Ala Ile Ser Arg Tyr Phe Asp Arg Val Gly Ser His 
            180                 185                 190         
Phe Leu Thr Gly Ile Val Met Gly Gly Arg Ala Ile Leu Ala Ser Ser 
        195                 200                 205             
Thr Asn Lys Leu Arg Val Lys Arg Asp Tyr Ser Val Ser Val Val Ala 
    210                 215                 220                 
Lys Ala Ser Tyr Glu Gly Leu Thr Gly Gln Leu Ser Ala Glu Ala Lys 
225                 230                 235                 240 
Ala Lys Tyr Gly Glu Ser Ile Ser Ser Phe Thr Gln Tyr Ser Asn Thr 
                245                 250                 255     
His Gln Glu Val Arg Gly Gly Asp Gly Ala Lys Ala His Gly Val Phe 
            260                 265                 270         
Ser Gly Lys Lys Glu Asp Phe Gln Ala Trp Val Asp Ser Val Ser Ala 
        275                 280                 285             
Ser Pro Asp Phe Val Asp Phe Val Pro Thr Ile Pro Met Gln Glu Ile 
    290                 295                 300                 
Trp Thr Leu Cys Ser Ser Glu Ala Gln Ala Glu Ala Met Arg Lys His 
305                 310                 315                 320 
Phe Asp Asp Val Trp Ala Pro Ala Gln Ser Glu Lys Phe Arg Val Lys 
                325                 330                 335     
Ala Asn Tyr Ile Asp Gln Leu Val Val Ile Thr Gly Gly Ser Ser Thr 
            340                 345                 350         
Ile Glu Pro Pro Val Gly Tyr Ser Lys Ile Glu Tyr Asp Leu Asn Ala 
        355                 360                 365             
Gly Ala Gly Gly Asp Phe Ile Tyr Leu Cys Tyr His Glu Gln Thr Trp 
    370                 375                 380                 
Gln Ala Asp Arg Pro Lys Asp Ala Val Thr Asp Ile Arg Ile Ile Phe 
385                 390                 395                 400 
Asn Lys Glu Pro Thr Pro Pro Gly Tyr Thr Lys Leu Pro Gln Asp Leu 
                405                 410                 415     
Asn Lys Gly Ala Gly Gly Asp Asp Val Phe Leu Cys Tyr Lys Thr Glu 
            420                 425                 430         
Ala Tyr Asn Thr Asp Thr Ala Ile Asn Lys Val Thr Val Ile Gly Gly 
        435                 440                 445             
Asn Asn Ala Asp Ile Asn Ala Pro Tyr Gly Tyr Leu Lys Val Pro Gly 
    450                 455                 460                 
Asp Leu Asn Arg Gly Ala Gly Gly Asn Phe Ile Tyr Ala Cys Thr Phe 
465                 470                 475                 480 
Val Gly Lys 
            

<210>  317
<211>  483
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  317
Met Glu Asn Ile Asp Leu Pro Gln Gly Leu Val Asn Phe Ser Thr Gln 
1               5                   10                  15      
His Leu Gln Leu Ile Arg Phe Lys Ala Gly Leu Asn Glu Thr Val Leu 
            20                  25                  30          
Pro Gly Val Glu Ala Ile Gly Leu Gly Tyr Asn Pro Phe Ile Ser Tyr 
        35                  40                  45              
Ala Ser Val Asn Ser Gly Ala Val Gln Leu Phe Asp Trp Ala Thr Ala 
    50                  55                  60                  
Lys Lys Arg Glu Val Pro Phe Lys Ala Gly Tyr Phe Val Pro Glu Leu 
65                  70                  75                  80  
Val Asp Val Gln Gln Asn Asp Ser Ala Thr Tyr Thr Asn Val Ser Gly 
                85                  90                  95      
Asn Thr Leu Ser Glu Tyr Gln Arg Ser Leu Ala Thr Ser Val Ala Ile 
            100                 105                 110         
Glu Gly Arg Tyr Asn Phe Phe Ser Gly Ser Leu Ser Thr Asp Phe Asp 
        115                 120                 125             
Ser Asn Ser Leu Arg Asn Ala Glu Asn Glu Phe Thr Arg Ile Gln Gln 
    130                 135                 140                 
Ser Ile Asn Leu Trp Ser Leu Arg Leu Pro Ser Val Lys Ser Leu Arg 
145                 150                 155                 160 
Glu Leu Met Leu Pro His Met Arg Gln Gln Leu Asp Glu Leu Asn Val 
                165                 170                 175     
Asn Asp Pro Lys Ala Ile Ser Arg Tyr Phe Asp Arg Val Gly Ser His 
            180                 185                 190         
Phe Leu Thr Gly Ile Val Met Gly Gly Arg Ala Ile Leu Ala Ser Ser 
        195                 200                 205             
Thr Asn Lys Leu Arg Val Lys Arg Asp Tyr Ser Val Ser Val Val Ala 
    210                 215                 220                 
Lys Ala Ser Tyr Glu Gly Leu Thr Gly Gln Leu Ser Ala Glu Ala Lys 
225                 230                 235                 240 
Ala Lys Tyr Gly Glu Ser Ile Ser Ser Phe Thr Gln Tyr Ser Asn Thr 
                245                 250                 255     
His Gln Glu Val Arg Gly Gly Asp Gly Ala Lys Ala His Gly Val Phe 
            260                 265                 270         
Ser Gly Lys Lys Glu Asp Phe Gln Ala Trp Val Asp Ser Val Ser Ala 
        275                 280                 285             
Ser Pro Asp Phe Val Asp Phe Val Pro Thr Ile Pro Met Gln Glu Ile 
    290                 295                 300                 
Trp Thr Leu Cys Ser Ser Glu Ala Gln Ala Glu Ala Met Arg Lys His 
305                 310                 315                 320 
Tyr Asp Asp Val Trp Ala Pro Ala Gln Ser Glu Lys Phe Arg Val Lys 
                325                 330                 335     
Ala Asn Tyr Ile Asp Gln Leu Val Val Ile Thr Gly Gly Ser Ser Thr 
            340                 345                 350         
Ile Glu Pro Pro Val Gly Tyr Ser Lys Leu Glu Tyr Asp Leu Asn Ala 
        355                 360                 365             
Gly Ala Gly Gly Asp Phe Ile Tyr Leu Cys Tyr His Glu Gln Thr Trp 
    370                 375                 380                 
Gln Ala Asp Arg Pro Lys Asp Ala Val Thr Asp Ile Arg Ile Ile Phe 
385                 390                 395                 400 
Asn Lys Glu Pro Thr Pro Pro Gly Tyr Thr Lys Leu Pro Gln Asp Leu 
                405                 410                 415     
Asn Lys Gly Ala Gly Gly Asp Asp Val Phe Leu Cys Tyr Lys Thr Glu 
            420                 425                 430         
Ala Tyr Asn Thr Asp Thr Ala Ile Asn Lys Val Thr Val Ile Gly Gly 
        435                 440                 445             
Asn Asn Ala Asp Leu Asn Ala Pro Tyr Gly Tyr Leu Lys Val Pro Gly 
    450                 455                 460                 
Asp Leu Asn Arg Gly Ala Gly Gly Asn Phe Ile Tyr Ala Cys Thr Phe 
465                 470                 475                 480 
Val Gly Lys 
            

<210>  318
<211>  483
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  318
Met Glu Asn Ile Asp Leu Pro Gln Gly Leu Val Asn Phe Ser Thr Gln 
1               5                   10                  15      
His Leu Gln Leu Ile Arg Phe Lys Ala Gly Leu Asn Glu Thr Val Leu 
            20                  25                  30          
Pro Gly Val Glu Ala Ile Gly Leu Gly Tyr Asn Pro Phe Ile Ser Tyr 
        35                  40                  45              
Ala Ser Val Asn Ser Gly Ala Val Gln Leu Phe Asp Trp Ala Thr Ala 
    50                  55                  60                  
Lys Lys Arg Glu Val Pro Phe Lys Ala Gly Tyr Phe Val Pro Glu Ile 
65                  70                  75                  80  
Val Asp Val Gln Gln Asn Asp Ser Ala Thr Phe Thr Asn Val Ser Gly 
                85                  90                  95      
Asn Thr Ile Ser Glu Tyr Gln Arg Ser Leu Ala Thr Ser Val Ala Ile 
            100                 105                 110         
Glu Gly Arg Tyr Asn Phe Phe Ser Gly Ser Leu Ser Thr Asp Phe Asp 
        115                 120                 125             
Ser Asn Ser Leu Arg Asn Ala Glu Asn Glu Phe Thr Arg Ile Gln Gln 
    130                 135                 140                 
Ser Ile Asn Leu Trp Ser Leu Arg Leu Pro Ser Val Lys Ser Leu Arg 
145                 150                 155                 160 
Glu Leu Met Leu Pro His Met Arg Gln Gln Leu Asp Glu Leu Asn Val 
                165                 170                 175     
Asn Asp Pro Lys Ala Ile Ser Arg Tyr Phe Asp Arg Val Gly Ser His 
            180                 185                 190         
Phe Leu Thr Gly Ile Val Met Gly Gly Arg Ala Ile Leu Ala Ser Ser 
        195                 200                 205             
Thr Asn Lys Leu Arg Val Lys Arg Asp Tyr Ser Val Ser Val Val Ala 
    210                 215                 220                 
Lys Ala Ser Tyr Glu Gly Leu Thr Gly Gln Leu Ser Ala Glu Ala Lys 
225                 230                 235                 240 
Ala Lys Tyr Gly Glu Ser Ile Ser Ser Phe Thr Gln Tyr Ser Asn Thr 
                245                 250                 255     
His Gln Glu Val Arg Gly Gly Asp Gly Ala Lys Ala His Gly Val Phe 
            260                 265                 270         
Ser Gly Lys Lys Glu Asp Phe Gln Ala Trp Val Asp Ser Val Ser Ala 
        275                 280                 285             
Ser Pro Asp Phe Val Asp Phe Val Pro Thr Ile Pro Met Gln Glu Ile 
    290                 295                 300                 
Trp Thr Leu Cys Ser Ser Glu Ala Gln Ala Glu Ala Met Arg Lys His 
305                 310                 315                 320 
Tyr Asp Asp Val Trp Ala Pro Ala Gln Ser Glu Lys Phe Arg Val Lys 
                325                 330                 335     
Ala Asn Tyr Ile Asp Gln Leu Val Val Ile Thr Gly Gly Ser Ser Thr 
            340                 345                 350         
Ile Glu Pro Pro Val Gly Tyr Ser Lys Ile Glu Tyr Asp Leu Asn Ala 
        355                 360                 365             
Gly Ala Gly Gly Asp Phe Ile Tyr Leu Cys Tyr His Glu Gln Thr Trp 
    370                 375                 380                 
Gln Ala Asp Arg Pro Lys Asp Ala Val Thr Asp Ile Arg Ile Ile Phe 
385                 390                 395                 400 
Asn Lys Glu Pro Thr Pro Pro Gly Tyr Thr Lys Leu Pro Gln Asp Leu 
                405                 410                 415     
Asn Lys Gly Ala Gly Gly Asp Asp Val Phe Leu Cys Tyr Lys Thr Glu 
            420                 425                 430         
Ala Tyr Asn Thr Asp Thr Ala Leu Asn Lys Val Thr Val Ile Gly Gly 
        435                 440                 445             
Asn Asn Ala Asp Ile Asn Ala Pro Phe Gly Tyr Leu Lys Val Pro Gly 
    450                 455                 460                 
Asp Leu Asn Arg Gly Ala Gly Gly Asn Phe Ile Tyr Ala Cys Thr Phe 
465                 470                 475                 480 
Val Gly Lys 
            

<210>  319
<211>  483
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  319
Met Glu Asn Ile Asp Leu Pro Gln Gly Leu Val Asn Phe Ser Thr Gln 
1               5                   10                  15      
His Leu Gln Leu Ile Arg Phe Lys Ala Gly Leu Asn Glu Thr Val Leu 
            20                  25                  30          
Pro Gly Val Glu Ala Ile Gly Leu Gly Tyr Asn Pro Phe Ile Ser Tyr 
        35                  40                  45              
Ala Ser Val Asn Ser Gly Ala Val Gln Leu Phe Asp Trp Ala Thr Ala 
    50                  55                  60                  
Lys Lys Arg Glu Val Pro Phe Lys Ala Gly Tyr Phe Val Pro Glu Leu 
65                  70                  75                  80  
Val Asp Val Gln Gln Asn Asp Ser Ala Thr Phe Thr Asn Val Ser Gly 
                85                  90                  95      
Asn Thr Leu Ser Glu Tyr Gln Arg Ser Leu Ala Thr Ser Val Ala Ile 
            100                 105                 110         
Glu Gly Arg Tyr Asn Phe Phe Ser Gly Ser Leu Ser Thr Asp Phe Asp 
        115                 120                 125             
Ser Asn Ser Leu Arg Asn Ala Glu Asn Glu Phe Thr Arg Ile Gln Gln 
    130                 135                 140                 
Ser Ile Asn Leu Trp Ser Leu Arg Leu Pro Ser Val Lys Ser Leu Arg 
145                 150                 155                 160 
Glu Leu Met Leu Pro His Met Arg Gln Gln Leu Asp Glu Leu Asn Val 
                165                 170                 175     
Asn Asp Pro Lys Ala Ile Ser Arg Tyr Phe Asp Arg Val Gly Ser His 
            180                 185                 190         
Phe Leu Thr Gly Ile Val Met Gly Gly Arg Ala Ile Leu Ala Ser Ser 
        195                 200                 205             
Thr Asn Lys Leu Arg Val Lys Arg Asp Tyr Ser Val Ser Val Val Ala 
    210                 215                 220                 
Lys Ala Ser Tyr Glu Gly Leu Thr Gly Gln Leu Ser Ala Glu Ala Lys 
225                 230                 235                 240 
Ala Lys Tyr Gly Glu Ser Ile Ser Ser Phe Thr Gln Tyr Ser Asn Thr 
                245                 250                 255     
His Gln Glu Val Arg Gly Gly Asp Gly Ala Lys Ala His Gly Val Phe 
            260                 265                 270         
Ser Gly Lys Lys Glu Asp Phe Gln Ala Trp Val Asp Ser Val Ser Ala 
        275                 280                 285             
Ser Pro Asp Phe Val Asp Phe Val Pro Thr Ile Pro Met Gln Glu Ile 
    290                 295                 300                 
Trp Thr Leu Cys Ser Ser Glu Ala Gln Ala Glu Ala Met Arg Lys His 
305                 310                 315                 320 
Tyr Asp Asp Val Trp Ala Pro Ala Gln Ser Glu Lys Tyr Arg Val Lys 
                325                 330                 335     
Ala Asn Tyr Ile Asp Gln Leu Val Val Leu Thr Gly Gly Ser Ser Thr 
            340                 345                 350         
Ile Glu Pro Pro Val Gly Tyr Ser Lys Leu Glu Tyr Asp Leu Asn Ala 
        355                 360                 365             
Gly Ala Gly Gly Asp Phe Ile Tyr Leu Cys Tyr His Glu Gln Thr Trp 
    370                 375                 380                 
Gln Ala Asp Arg Pro Lys Asp Ala Val Thr Asp Ile Arg Ile Ile Phe 
385                 390                 395                 400 
Asn Lys Glu Pro Thr Pro Pro Gly Tyr Thr Lys Leu Pro Gln Asp Leu 
                405                 410                 415     
Asn Lys Gly Ala Gly Gly Asp Asp Val Phe Leu Cys Tyr Lys Thr Glu 
            420                 425                 430         
Ala Phe Asn Thr Asp Thr Ala Leu Asn Lys Val Thr Val Ile Gly Gly 
        435                 440                 445             
Asn Asn Ala Asp Ile Asn Ala Pro Tyr Gly Tyr Leu Lys Val Pro Gly 
    450                 455                 460                 
Asp Leu Asn Arg Gly Ala Gly Gly Asn Phe Ile Tyr Ala Cys Thr Phe 
465                 470                 475                 480 
Val Gly Lys 
            

<210>  320
<211>  483
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  320
Met Glu Asn Ile Asp Leu Pro Gln Gly Leu Val Asn Phe Ser Thr Gln 
1               5                   10                  15      
His Leu Gln Leu Ile Arg Phe Lys Ala Gly Leu Asn Glu Thr Val Leu 
            20                  25                  30          
Pro Gly Val Glu Ala Ile Gly Leu Gly Tyr Asn Pro Phe Ile Ser Tyr 
        35                  40                  45              
Ala Ser Val Asn Ser Gly Ala Val Gln Leu Phe Asp Trp Ala Thr Ala 
    50                  55                  60                  
Lys Lys Arg Glu Val Pro Phe Lys Ala Gly Tyr Phe Val Pro Glu Leu 
65                  70                  75                  80  
Val Asp Val Gln Gln Asn Asp Ser Ala Thr Phe Thr Asn Val Ser Gly 
                85                  90                  95      
Asn Thr Leu Ser Glu Tyr Gln Arg Ser Leu Ala Thr Ser Val Ala Ile 
            100                 105                 110         
Glu Gly Arg Tyr Asn Phe Phe Ser Gly Ser Leu Ser Thr Asp Phe Asp 
        115                 120                 125             
Ser Asn Ser Leu Arg Asn Ala Glu Asn Glu Phe Thr Arg Ile Gln Gln 
    130                 135                 140                 
Ser Ile Asn Leu Trp Ser Leu Arg Leu Pro Ser Val Lys Ser Leu Arg 
145                 150                 155                 160 
Glu Leu Met Leu Pro His Met Arg Gln Gln Leu Asp Glu Leu Asn Val 
                165                 170                 175     
Asn Asp Pro Lys Ala Ile Ser Arg Tyr Phe Asp Arg Val Gly Ser His 
            180                 185                 190         
Phe Leu Thr Gly Ile Val Met Gly Gly Arg Ala Ile Leu Ala Ser Ser 
        195                 200                 205             
Thr Asn Lys Leu Arg Val Lys Arg Asp Tyr Ser Val Ser Val Val Ala 
    210                 215                 220                 
Lys Ala Ser Tyr Glu Gly Leu Thr Gly Gln Leu Ser Ala Glu Ala Lys 
225                 230                 235                 240 
Ala Lys Tyr Gly Glu Ser Ile Ser Ser Phe Thr Gln Tyr Ser Asn Thr 
                245                 250                 255     
His Gln Glu Val Arg Gly Gly Asp Gly Ala Lys Ala His Gly Val Phe 
            260                 265                 270         
Ser Gly Lys Lys Glu Asp Phe Gln Ala Trp Val Asp Ser Val Ser Ala 
        275                 280                 285             
Ser Pro Asp Phe Val Asp Phe Val Pro Thr Ile Pro Met Gln Glu Ile 
    290                 295                 300                 
Trp Thr Leu Cys Ser Ser Glu Ala Gln Ala Glu Ala Met Arg Lys His 
305                 310                 315                 320 
Phe Asp Asp Val Trp Ala Pro Ala Gln Ser Glu Lys Tyr Arg Val Lys 
                325                 330                 335     
Ala Asn Tyr Ile Asp Gln Leu Val Val Leu Thr Gly Gly Ser Ser Thr 
            340                 345                 350         
Ile Glu Pro Pro Val Gly Tyr Ser Lys Ile Glu Tyr Asp Leu Asn Ala 
        355                 360                 365             
Gly Ala Gly Gly Asp Phe Ile Tyr Leu Cys Tyr His Glu Gln Thr Trp 
    370                 375                 380                 
Gln Ala Asp Arg Pro Lys Asp Ala Val Thr Asp Ile Arg Ile Ile Phe 
385                 390                 395                 400 
Asn Lys Glu Pro Thr Pro Pro Gly Tyr Thr Lys Leu Pro Gln Asp Leu 
                405                 410                 415     
Asn Lys Gly Ala Gly Gly Asp Asp Val Phe Leu Cys Tyr Lys Thr Glu 
            420                 425                 430         
Ala Phe Asn Thr Asp Thr Ala Ile Asn Lys Val Thr Val Ile Gly Gly 
        435                 440                 445             
Asn Asn Ala Asp Ile Asn Ala Pro Phe Gly Tyr Leu Lys Val Pro Gly 
    450                 455                 460                 
Asp Leu Asn Arg Gly Ala Gly Gly Asn Phe Ile Tyr Ala Cys Thr Phe 
465                 470                 475                 480 
Val Gly Lys 
            

<210>  321
<211>  392
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  321
Met Glu Asn Ile Asp Leu Pro Gln Gly Leu Val Asn Phe Ser Thr Gln 
1               5                   10                  15      
His Leu Gln Leu Ile Arg Phe Lys Ala Gly Leu Asn Glu Thr Val Leu 
            20                  25                  30          
Pro Gly Val Glu Ala Ile Gly Leu Gly Tyr Asn Pro Phe Ile Ser Tyr 
        35                  40                  45              
Ala Ser Val Asn Ser Gly Ala Val Gln Leu Phe Asp Trp Ala Thr Ala 
    50                  55                  60                  
Lys Lys Arg Glu Val Pro Phe Lys Ala Gly Tyr Phe Val Pro Glu Leu 
65                  70                  75                  80  
Val Asp Val Gln Gln Asn Asp Ser Ala Thr Phe Thr Asn Val Ser Gly 
                85                  90                  95      
Asn Thr Leu Ser Glu Tyr Gln Arg Ser Leu Ala Thr Ser Val Ala Ile 
            100                 105                 110         
Glu Gly Arg Tyr Asn Phe Phe Ser Gly Ser Leu Ser Thr Asp Phe Asp 
        115                 120                 125             
Ser Asn Ser Leu Arg Asn Ala Glu Asn Glu Phe Thr Arg Ile Gln Gln 
    130                 135                 140                 
Ser Ile Asn Leu Trp Ser Leu Arg Leu Pro Ser Val Lys Ser Leu Arg 
145                 150                 155                 160 
Glu Leu Met Leu Pro His Met Arg Gln Gln Leu Asp Glu Leu Asn Val 
                165                 170                 175     
Asn Asp Pro Lys Ala Ile Ser Arg Tyr Phe Asp Arg Val Gly Ser His 
            180                 185                 190         
Phe Leu Thr Gly Ile Val Met Gly Gly Arg Ala Ile Leu Ala Ser Ser 
        195                 200                 205             
Thr Asn Lys Leu Arg Val Lys Arg Asp Tyr Ser Val Ser Val Val Ala 
    210                 215                 220                 
Lys Ala Ser Tyr Glu Gly Leu Thr Gly Gln Leu Ser Ala Glu Ala Lys 
225                 230                 235                 240 
Ala Lys Tyr Gly Glu Ser Ile Ser Ser Phe Thr Gln Tyr Ser Asn Thr 
                245                 250                 255     
His Gln Glu Val Arg Gly Gly Asp Gly Ala Lys Ala His Gly Val Phe 
            260                 265                 270         
Ser Gly Lys Lys Glu Asp Phe Gln Ala Trp Val Asp Ser Val Ser Ala 
        275                 280                 285             
Ser Pro Asp Phe Val Asp Phe Val Pro Thr Ile Pro Met Gln Glu Ile 
    290                 295                 300                 
Trp Thr Leu Cys Ser Ser Glu Ala Gln Ala Glu Pro Cys Ala Ser Ile 
305                 310                 315                 320 
Ser Met Thr Ser Gly Arg Arg Arg Asn Arg Lys Ser Ser Gly Ser Arg 
                325                 330                 335     
Leu Thr Thr Ser Thr Asn Trp Trp Ser Ser Pro Ala Val Val Gln Pro 
            340                 345                 350         
Ser Asn His Arg Ser Ala Thr Ala Arg Ser Ser Thr Thr Ser Met Pro 
        355                 360                 365             
Val Pro Ala Val Thr Ser Ser Thr Cys Ala Ile Thr Asn Lys Pro Gly 
    370                 375                 380                 
Arg Pro Thr Gly Leu Lys Met Leu 
385                 390         

<210>  322
<211>  483
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  322
Met Glu Asn Ile Asp Leu Pro Gln Gly Leu Val Asn Phe Ser Thr Gln 
1               5                   10                  15      
His Leu Gln Leu Ile Arg Phe Lys Ala Gly Leu Asn Glu Thr Val Leu 
            20                  25                  30          
Pro Gly Val Glu Ala Ile Gly Leu Gly Tyr Asn Pro Phe Ile Ser Tyr 
        35                  40                  45              
Ala Ser Val Asn Ser Gly Ala Val Gln Leu Phe Asp Trp Ala Thr Ala 
    50                  55                  60                  
Lys Lys Arg Glu Val Pro Phe Lys Ala Gly Tyr Phe Val Pro Glu Leu 
65                  70                  75                  80  
Val Asp Val Gln Gln Asn Asp Ser Ala Thr Phe Thr Asn Val Ser Gly 
                85                  90                  95      
Asn Thr Ile Ser Glu Tyr Gln Arg Ser Leu Ala Thr Ser Val Ala Ile 
            100                 105                 110         
Glu Gly Arg Tyr Asn Phe Phe Ser Gly Ser Leu Ser Thr Asp Phe Asp 
        115                 120                 125             
Ser Asn Ser Leu Arg Asn Ala Glu Asn Glu Phe Thr Arg Ile Gln Gln 
    130                 135                 140                 
Ser Ile Asn Leu Trp Ser Leu Arg Leu Pro Ser Val Lys Ser Leu Arg 
145                 150                 155                 160 
Glu Leu Met Leu Pro His Met Arg Gln Gln Leu Asp Glu Leu Asn Val 
                165                 170                 175     
Asn Asp Pro Lys Ala Ile Ser Arg Tyr Phe Asp Arg Val Gly Ser His 
            180                 185                 190         
Phe Leu Thr Gly Ile Val Met Gly Gly Arg Ala Ile Leu Ala Ser Ser 
        195                 200                 205             
Thr Asn Lys Leu Arg Val Lys Arg Asp Tyr Ser Val Ser Val Val Ala 
    210                 215                 220                 
Lys Ala Ser Tyr Glu Gly Leu Thr Gly Gln Leu Ser Ala Glu Ala Lys 
225                 230                 235                 240 
Ala Lys Tyr Gly Glu Ser Ile Ser Ser Phe Thr Gln Tyr Ser Asn Thr 
                245                 250                 255     
His Gln Glu Val Arg Gly Gly Asp Gly Ala Lys Ala His Gly Val Phe 
            260                 265                 270         
Ser Gly Lys Lys Glu Asp Phe Gln Ala Trp Val Asp Ser Val Ser Ala 
        275                 280                 285             
Ser Pro Asp Phe Val Asp Phe Val Pro Thr Ile Pro Met Gln Glu Ile 
    290                 295                 300                 
Trp Thr Leu Cys Ser Ser Glu Ala Gln Ala Glu Ala Met Arg Lys His 
305                 310                 315                 320 
Phe Asp Asp Val Trp Ala Pro Ala Gln Ser Glu Lys Tyr Arg Val Lys 
                325                 330                 335     
Ala Asn Tyr Leu Asp Gln Leu Val Val Ile Thr Gly Gly Ser Ser Thr 
            340                 345                 350         
Ile Glu Pro Pro Val Gly Tyr Ser Lys Ile Glu Tyr Asp Leu Asn Ala 
        355                 360                 365             
Gly Ala Gly Gly Asp Phe Ile Tyr Leu Cys Tyr His Glu Gln Thr Trp 
    370                 375                 380                 
Gln Ala Asp Arg Pro Lys Asp Ala Val Thr Asp Ile Arg Ile Ile Phe 
385                 390                 395                 400 
Asn Lys Glu Pro Thr Pro Pro Gly Tyr Thr Lys Leu Pro Gln Asp Leu 
                405                 410                 415     
Asn Lys Gly Ala Gly Gly Asp Asp Val Phe Leu Cys Tyr Lys Thr Glu 
            420                 425                 430         
Ala Phe Asn Thr Asp Thr Ala Leu Asn Lys Val Thr Val Ile Gly Gly 
        435                 440                 445             
Asn Asn Ala Asp Ile Asn Ala Pro Tyr Gly Tyr Leu Lys Val Pro Gly 
    450                 455                 460                 
Asp Leu Asn Arg Gly Ala Gly Gly Asn Phe Ile Tyr Ala Cys Thr Phe 
465                 470                 475                 480 
Val Gly Lys 
            

<210>  323
<211>  483
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  323
Met Glu Asn Ile Asp Leu Pro Gln Gly Leu Val Asn Phe Ser Thr Gln 
1               5                   10                  15      
His Leu Gln Leu Ile Arg Phe Lys Ala Gly Leu Asn Glu Thr Val Leu 
            20                  25                  30          
Pro Gly Val Glu Ala Ile Gly Leu Gly Tyr Asn Pro Phe Ile Ser Tyr 
        35                  40                  45              
Ala Ser Val Asn Ser Gly Ala Val Gln Leu Phe Asp Trp Ala Thr Ala 
    50                  55                  60                  
Lys Lys Arg Glu Val Pro Phe Lys Ala Gly Tyr Phe Val Pro Glu Leu 
65                  70                  75                  80  
Val Asp Val Gln Gln Asn Asp Ser Ala Thr Phe Thr Asn Val Ser Gly 
                85                  90                  95      
Asn Thr Ile Ser Glu Tyr Gln Arg Ser Leu Ala Thr Ser Val Ala Ile 
            100                 105                 110         
Glu Gly Arg Tyr Asn Phe Phe Ser Gly Ser Leu Ser Thr Asp Phe Asp 
        115                 120                 125             
Ser Asn Ser Leu Arg Asn Ala Glu Asn Glu Phe Thr Arg Ile Gln Gln 
    130                 135                 140                 
Ser Ile Asn Leu Trp Ser Leu Arg Leu Pro Ser Val Lys Ser Leu Arg 
145                 150                 155                 160 
Glu Leu Met Leu Pro His Met Arg Gln Gln Leu Asp Glu Leu Asn Val 
                165                 170                 175     
Asn Asp Pro Lys Ala Ile Ser Arg Tyr Phe Asp Arg Val Gly Ser His 
            180                 185                 190         
Phe Leu Thr Gly Ile Val Met Gly Gly Arg Ala Ile Leu Ala Ser Ser 
        195                 200                 205             
Thr Asn Lys Leu Arg Val Lys Arg Asp Tyr Ser Val Ser Val Val Ala 
    210                 215                 220                 
Lys Ala Ser Tyr Glu Gly Leu Thr Gly Gln Leu Ser Ala Glu Ala Lys 
225                 230                 235                 240 
Ala Lys Tyr Gly Glu Ser Ile Ser Ser Phe Thr Gln Tyr Ser Asn Thr 
                245                 250                 255     
His Gln Glu Val Arg Gly Gly Asp Gly Ala Lys Ala His Gly Val Phe 
            260                 265                 270         
Ser Gly Lys Lys Glu Asp Phe Gln Ala Trp Val Asp Ser Val Ser Ala 
        275                 280                 285             
Ser Pro Asp Phe Val Asp Phe Val Pro Thr Ile Pro Met Gln Glu Ile 
    290                 295                 300                 
Trp Thr Leu Cys Ser Ser Glu Ala Gln Ala Glu Ala Met Arg Lys His 
305                 310                 315                 320 
Tyr Asp Asp Val Trp Ala Pro Ala Gln Ser Glu Lys Phe Arg Val Lys 
                325                 330                 335     
Ala Asn Tyr Ile Asp Gln Leu Val Val Ile Thr Gly Gly Ser Ser Thr 
            340                 345                 350         
Ile Glu Pro Pro Val Gly Tyr Ser Lys Ile Glu Tyr Asp Leu Asn Ala 
        355                 360                 365             
Gly Ala Gly Gly Asp Phe Ile Tyr Leu Cys Tyr His Glu Gln Thr Trp 
    370                 375                 380                 
Gln Ala Asp Arg Pro Lys Asp Ala Val Thr Asp Ile Arg Ile Ile Phe 
385                 390                 395                 400 
Asn Lys Glu Pro Thr Pro Pro Gly Tyr Thr Lys Leu Pro Gln Asp Leu 
                405                 410                 415     
Asn Lys Gly Ala Gly Gly Asp Asp Val Phe Leu Cys Tyr Lys Thr Glu 
            420                 425                 430         
Ala Tyr Asn Thr Asp Thr Ala Ile Asn Lys Val Thr Val Leu Gly Gly 
        435                 440                 445             
Asn Asn Ala Asp Ile Asn Ala Pro Tyr Gly Tyr Leu Lys Val Pro Gly 
    450                 455                 460                 
Asp Leu Asn Arg Gly Ala Gly Gly Asn Phe Ile Tyr Ala Cys Thr Phe 
465                 470                 475                 480 
Val Gly Lys 
            

<210>  324
<211>  483
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  324
Met Glu Asn Ile Asp Leu Pro Gln Gly Leu Val Asn Phe Ser Thr Gln 
1               5                   10                  15      
His Leu Gln Leu Ile Arg Phe Lys Ala Gly Leu Asn Glu Thr Val Leu 
            20                  25                  30          
Pro Gly Val Glu Ala Ile Gly Leu Gly Tyr Asn Pro Phe Ile Ser Tyr 
        35                  40                  45              
Ala Ser Val Asn Ser Gly Ala Val Gln Leu Phe Asp Trp Ala Thr Ala 
    50                  55                  60                  
Lys Lys Arg Glu Val Pro Phe Lys Ala Gly Tyr Phe Val Pro Glu Leu 
65                  70                  75                  80  
Val Asp Val Gln Gln Asn Asp Ser Ala Thr Phe Thr Asn Val Ser Gly 
                85                  90                  95      
Asn Thr Ile Ser Glu Tyr Gln Arg Ser Leu Ala Thr Ser Val Ala Ile 
            100                 105                 110         
Glu Gly Arg Tyr Asn Phe Phe Ser Gly Ser Leu Ser Thr Asp Phe Asp 
        115                 120                 125             
Ser Asn Ser Leu Arg Asn Ala Glu Asn Glu Phe Thr Arg Ile Gln Gln 
    130                 135                 140                 
Ser Ile Asn Leu Trp Ser Leu Arg Leu Pro Ser Val Lys Ser Leu Arg 
145                 150                 155                 160 
Glu Leu Met Leu Pro His Met Arg Gln Gln Leu Asp Glu Leu Asn Val 
                165                 170                 175     
Asn Asp Pro Lys Ala Ile Ser Arg Tyr Phe Asp Arg Val Gly Ser His 
            180                 185                 190         
Phe Leu Thr Gly Ile Val Met Gly Gly Arg Ala Ile Leu Ala Ser Ser 
        195                 200                 205             
Thr Asn Lys Leu Arg Val Lys Arg Asp Tyr Ser Val Ser Val Val Ala 
    210                 215                 220                 
Lys Ala Ser Tyr Glu Gly Leu Thr Gly Gln Leu Ser Ala Glu Ala Lys 
225                 230                 235                 240 
Ala Lys Tyr Gly Glu Ser Ile Ser Ser Phe Thr Gln Tyr Ser Asn Thr 
                245                 250                 255     
His Gln Glu Val Arg Gly Gly Asp Gly Ala Lys Ala His Gly Val Phe 
            260                 265                 270         
Ser Gly Lys Lys Glu Asp Phe Gln Ala Trp Val Asp Ser Val Ser Ala 
        275                 280                 285             
Ser Pro Asp Phe Val Asp Phe Val Pro Thr Ile Pro Met Gln Glu Ile 
    290                 295                 300                 
Trp Thr Leu Cys Ser Ser Glu Ala Gln Ala Glu Ala Met Arg Lys His 
305                 310                 315                 320 
Tyr Asp Asp Val Trp Ala Pro Ala Gln Ser Glu Lys Phe Arg Val Lys 
                325                 330                 335     
Ala Asn Tyr Ile Asp Gln Leu Val Val Ile Thr Gly Gly Ser Ser Thr 
            340                 345                 350         
Ile Glu Pro Pro Val Gly Tyr Ser Lys Ile Glu Tyr Asp Leu Asn Ala 
        355                 360                 365             
Gly Ala Gly Gly Asp Phe Ile Tyr Leu Cys Tyr His Glu Gln Thr Trp 
    370                 375                 380                 
Gln Ala Asp Arg Pro Lys Asp Ala Val Thr Asp Ile Arg Ile Ile Phe 
385                 390                 395                 400 
Asn Lys Glu Pro Thr Pro Pro Gly Tyr Thr Lys Leu Pro Gln Asp Leu 
                405                 410                 415     
Asn Lys Gly Ala Gly Gly Asp Asp Val Phe Leu Cys Tyr Lys Thr Glu 
            420                 425                 430         
Ala Tyr Asn Thr Asp Thr Ala Ile Asn Lys Val Thr Val Ile Gly Gly 
        435                 440                 445             
Asn Asn Ala Asp Ile Asn Ala Pro Phe Gly Tyr Leu Lys Val Pro Gly 
    450                 455                 460                 
Asp Leu Asn Arg Gly Ala Gly Gly Asn Phe Ile Tyr Ala Cys Thr Phe 
465                 470                 475                 480 
Val Gly Lys 
            

<210>  325
<211>  483
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  325
Met Glu Asn Ile Asp Leu Pro Gln Gly Leu Val Asn Phe Ser Thr Gln 
1               5                   10                  15      
His Leu Gln Leu Ile Arg Phe Lys Ala Gly Leu Asn Glu Thr Val Leu 
            20                  25                  30          
Pro Gly Val Glu Ala Ile Gly Leu Gly Tyr Asn Pro Phe Ile Ser Tyr 
        35                  40                  45              
Ala Ser Val Asn Ser Gly Ala Val Gln Leu Phe Asp Trp Ala Thr Ala 
    50                  55                  60                  
Lys Lys Arg Glu Val Pro Phe Lys Ala Gly Tyr Phe Val Pro Glu Leu 
65                  70                  75                  80  
Val Asp Val Gln Gln Asn Asp Ser Ala Thr Tyr Thr Asn Val Ser Gly 
                85                  90                  95      
Asn Thr Ile Ser Glu Tyr Gln Arg Ser Leu Ala Thr Ser Val Ala Ile 
            100                 105                 110         
Glu Gly Arg Tyr Asn Phe Phe Ser Gly Ser Leu Ser Thr Asp Phe Asp 
        115                 120                 125             
Ser Asn Ser Leu Arg Asn Ala Glu Asn Glu Phe Thr Arg Ile Gln Gln 
    130                 135                 140                 
Ser Ile Asn Leu Trp Ser Leu Arg Leu Pro Ser Val Lys Ser Leu Arg 
145                 150                 155                 160 
Glu Leu Met Leu Pro His Met Arg Gln Gln Leu Asp Glu Leu Asn Val 
                165                 170                 175     
Asn Asp Pro Lys Ala Ile Ser Arg Tyr Phe Asp Arg Val Gly Ser His 
            180                 185                 190         
Phe Leu Thr Gly Ile Val Met Gly Gly Arg Ala Ile Leu Ala Ser Ser 
        195                 200                 205             
Thr Asn Lys Leu Arg Val Lys Arg Asp Tyr Ser Val Ser Val Val Ala 
    210                 215                 220                 
Lys Ala Ser Tyr Glu Gly Leu Thr Gly Gln Leu Ser Ala Glu Ala Lys 
225                 230                 235                 240 
Ala Lys Tyr Gly Glu Ser Ile Ser Ser Phe Thr Gln Tyr Ser Asn Thr 
                245                 250                 255     
His Gln Glu Val Arg Gly Gly Asp Gly Ala Lys Ala His Gly Val Phe 
            260                 265                 270         
Ser Gly Lys Lys Glu Asp Phe Gln Ala Trp Val Asp Ser Val Ser Ala 
        275                 280                 285             
Ser Pro Asp Phe Val Asp Phe Val Pro Thr Ile Pro Met Gln Glu Ile 
    290                 295                 300                 
Trp Thr Leu Cys Ser Ser Glu Ala Gln Ala Glu Ala Met Arg Lys His 
305                 310                 315                 320 
Tyr Asp Asp Val Trp Ala Pro Ala Gln Ser Glu Lys Tyr Arg Val Lys 
                325                 330                 335     
Ala Asn Tyr Leu Asp Gln Leu Val Val Ile Thr Gly Gly Ser Ser Thr 
            340                 345                 350         
Ile Glu Pro Pro Val Gly Tyr Ser Lys Ile Glu Tyr Asp Leu Asn Ala 
        355                 360                 365             
Gly Ala Gly Gly Asp Phe Ile Tyr Leu Cys Tyr His Glu Gln Thr Trp 
    370                 375                 380                 
Gln Ala Asp Arg Pro Lys Asp Ala Val Thr Asp Ile Arg Ile Ile Phe 
385                 390                 395                 400 
Asn Lys Glu Pro Thr Pro Pro Gly Tyr Thr Lys Leu Pro Gln Asp Leu 
                405                 410                 415     
Asn Lys Gly Ala Gly Gly Asp Asp Val Phe Leu Cys Tyr Lys Thr Glu 
            420                 425                 430         
Ala Tyr Asn Thr Asp Thr Ala Leu Asn Lys Val Thr Val Ile Gly Gly 
        435                 440                 445             
Asn Asn Ala Asp Ile Asn Ala Pro Phe Gly Tyr Leu Lys Val Pro Gly 
    450                 455                 460                 
Asp Leu Asn Arg Gly Ala Gly Gly Asn Phe Ile Tyr Ala Cys Thr Phe 
465                 470                 475                 480 
Val Gly Lys 
            

<210>  326
<211>  483
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  326
Met Glu Asn Ile Asp Leu Pro Gln Gly Leu Val Asn Phe Ser Thr Gln 
1               5                   10                  15      
His Leu Gln Leu Ile Arg Phe Lys Ala Gly Leu Asn Glu Thr Val Leu 
            20                  25                  30          
Pro Gly Val Glu Ala Ile Gly Leu Gly Tyr Asn Pro Phe Ile Ser Tyr 
        35                  40                  45              
Ala Ser Val Asn Ser Gly Ala Val Gln Leu Phe Asp Trp Ala Thr Ala 
    50                  55                  60                  
Lys Lys Arg Glu Val Pro Phe Lys Ala Gly Tyr Phe Val Pro Glu Leu 
65                  70                  75                  80  
Val Asp Val Gln Gln Asn Asp Ser Ala Thr Phe Thr Asn Val Ser Gly 
                85                  90                  95      
Asn Thr Ile Ser Glu Tyr Gln Arg Ser Leu Ala Thr Ser Val Ala Ile 
            100                 105                 110         
Glu Gly Arg Tyr Asn Phe Phe Ser Gly Ser Leu Ser Thr Asp Phe Asp 
        115                 120                 125             
Ser Asn Ser Leu Arg Asn Ala Glu Asn Glu Phe Thr Arg Ile Gln Gln 
    130                 135                 140                 
Ser Ile Asn Leu Trp Ser Leu Arg Leu Pro Ser Val Lys Ser Leu Arg 
145                 150                 155                 160 
Glu Leu Met Leu Pro His Met Arg Gln Gln Leu Asp Glu Leu Asn Val 
                165                 170                 175     
Asn Asp Pro Lys Ala Ile Ser Arg Tyr Phe Asp Arg Val Gly Ser His 
            180                 185                 190         
Phe Leu Thr Gly Ile Val Met Gly Gly Arg Ala Ile Leu Ala Ser Ser 
        195                 200                 205             
Thr Asn Lys Leu Arg Val Lys Arg Asp Tyr Ser Val Ser Val Val Ala 
    210                 215                 220                 
Lys Ala Ser Tyr Glu Gly Leu Thr Gly Gln Leu Ser Ala Glu Ala Lys 
225                 230                 235                 240 
Ala Lys Tyr Gly Glu Ser Ile Ser Ser Phe Thr Gln Tyr Ser Asn Thr 
                245                 250                 255     
His Gln Glu Val Arg Gly Gly Asp Gly Ala Lys Ala His Gly Val Phe 
            260                 265                 270         
Ser Gly Lys Lys Glu Asp Phe Gln Ala Trp Val Asp Ser Val Ser Ala 
        275                 280                 285             
Ser Pro Asp Phe Val Asp Phe Val Pro Thr Ile Pro Met Gln Glu Ile 
    290                 295                 300                 
Trp Thr Leu Cys Ser Ser Glu Ala Gln Ala Glu Ala Met Arg Lys His 
305                 310                 315                 320 
Tyr Asp Asp Val Trp Ala Pro Ala Gln Ser Glu Lys Phe Arg Val Lys 
                325                 330                 335     
Ala Asn Tyr Ile Asp Gln Leu Val Val Ile Thr Gly Gly Ser Ser Thr 
            340                 345                 350         
Ile Glu Pro Pro Val Gly Tyr Ser Lys Ile Glu Tyr Asp Leu Asn Ala 
        355                 360                 365             
Gly Ala Gly Gly Asp Phe Ile Tyr Leu Cys Tyr His Glu Gln Thr Trp 
    370                 375                 380                 
Gln Ala Asp Arg Pro Lys Asp Ala Val Thr Asp Ile Arg Ile Ile Phe 
385                 390                 395                 400 
Asn Lys Glu Pro Thr Pro Pro Gly Tyr Thr Lys Leu Pro Gln Asp Leu 
                405                 410                 415     
Asn Lys Gly Ala Gly Gly Asp Asp Val Phe Leu Cys Tyr Lys Thr Glu 
            420                 425                 430         
Ala Tyr Asn Thr Asp Thr Ala Ile Asn Lys Val Thr Val Ile Gly Gly 
        435                 440                 445             
Asn Asn Ala Asp Ile Asn Ala Pro Tyr Gly Tyr Leu Lys Val Pro Gly 
    450                 455                 460                 
Asp Leu Asn Arg Gly Ala Gly Gly Asn Phe Ile Tyr Ala Cys Thr Phe 
465                 470                 475                 480 
Val Gly Lys 
            

<210>  327
<211>  483
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  327
Met Glu Asn Ile Asp Leu Pro Gln Gly Leu Val Asn Phe Ser Thr Gln 
1               5                   10                  15      
His Leu Gln Leu Ile Arg Phe Lys Ala Gly Leu Asn Glu Thr Val Leu 
            20                  25                  30          
Pro Gly Val Glu Ala Ile Gly Leu Gly Tyr Asn Pro Phe Ile Ser Tyr 
        35                  40                  45              
Ala Ser Val Asn Ser Gly Ala Val Gln Leu Phe Asp Trp Ala Thr Ala 
    50                  55                  60                  
Lys Lys Arg Glu Val Pro Phe Lys Ala Gly Tyr Phe Val Pro Glu Ile 
65                  70                  75                  80  
Val Asp Val Gln Gln Asn Asp Ser Ala Thr Phe Thr Asn Val Ser Gly 
                85                  90                  95      
Asn Thr Ile Ser Glu Tyr Gln Arg Ser Leu Ala Thr Ser Val Ala Ile 
            100                 105                 110         
Glu Gly Arg Tyr Asn Phe Phe Ser Gly Ser Leu Ser Thr Asp Phe Asp 
        115                 120                 125             
Ser Asn Ser Leu Arg Asn Ala Glu Asn Glu Phe Thr Arg Ile Gln Gln 
    130                 135                 140                 
Ser Ile Asn Leu Trp Ser Leu Arg Leu Pro Ser Val Lys Ser Leu Arg 
145                 150                 155                 160 
Glu Leu Met Leu Pro His Met Arg Gln Gln Leu Asp Glu Leu Asn Val 
                165                 170                 175     
Asn Asp Pro Lys Ala Ile Ser Arg Tyr Phe Asp Arg Val Gly Ser His 
            180                 185                 190         
Phe Leu Thr Gly Ile Val Met Gly Gly Arg Ala Ile Leu Ala Ser Ser 
        195                 200                 205             
Thr Asn Lys Leu Arg Val Lys Arg Asp Tyr Ser Val Ser Val Val Ala 
    210                 215                 220                 
Lys Ala Ser Tyr Glu Gly Leu Thr Gly Gln Leu Ser Ala Glu Ala Lys 
225                 230                 235                 240 
Ala Lys Tyr Gly Glu Ser Ile Ser Ser Phe Thr Gln Tyr Ser Asn Thr 
                245                 250                 255     
His Gln Glu Val Arg Gly Gly Asp Gly Ala Lys Ala His Gly Val Phe 
            260                 265                 270         
Ser Gly Lys Lys Glu Asp Phe Gln Ala Trp Val Asp Ser Val Ser Ala 
        275                 280                 285             
Ser Pro Asp Phe Val Asp Phe Val Pro Thr Ile Pro Met Gln Glu Ile 
    290                 295                 300                 
Trp Thr Leu Cys Ser Ser Glu Ala Gln Ala Glu Ala Met Arg Lys His 
305                 310                 315                 320 
Tyr Asp Asp Val Trp Ala Pro Ala Gln Ser Glu Lys Phe Arg Val Lys 
                325                 330                 335     
Ala Asn Tyr Ile Asp Gln Leu Val Val Ile Thr Gly Gly Ser Ser Thr 
            340                 345                 350         
Ile Glu Pro Pro Val Gly Tyr Ser Lys Ile Glu Tyr Asp Leu Asn Ala 
        355                 360                 365             
Gly Ala Gly Gly Asp Phe Ile Tyr Leu Cys Tyr His Glu Gln Thr Trp 
    370                 375                 380                 
Gln Ala Asp Arg Pro Lys Asp Ala Val Thr Asp Ile Arg Ile Ile Phe 
385                 390                 395                 400 
Asn Lys Glu Pro Thr Pro Pro Gly Tyr Thr Lys Leu Pro Gln Asp Leu 
                405                 410                 415     
Asn Lys Gly Ala Gly Gly Asp Asp Val Phe Leu Cys Tyr Lys Thr Glu 
            420                 425                 430         
Ala Tyr Asn Thr Asp Thr Ala Ile Asn Lys Val Thr Val Ile Gly Gly 
        435                 440                 445             
Asn Asn Ala Asp Ile Asn Ala Pro Tyr Gly Tyr Leu Lys Val Pro Gly 
    450                 455                 460                 
Asp Leu Asn Arg Gly Ala Gly Gly Asn Phe Ile Tyr Ala Cys Thr Phe 
465                 470                 475                 480 
Val Gly Lys 
            

<210>  328
<211>  483
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  328
Met Glu Asn Ile Asp Leu Pro Gln Gly Leu Val Asn Phe Ser Thr Gln 
1               5                   10                  15      
His Leu Gln Leu Ile Arg Phe Lys Ala Gly Leu Asn Glu Thr Val Leu 
            20                  25                  30          
Pro Gly Val Glu Ala Ile Gly Leu Gly Tyr Asn Pro Phe Ile Ser Tyr 
        35                  40                  45              
Ala Ser Val Asn Ser Gly Ala Val Gln Leu Phe Asp Trp Ala Thr Ala 
    50                  55                  60                  
Lys Lys Arg Glu Val Pro Phe Lys Ala Gly Tyr Phe Val Pro Glu Leu 
65                  70                  75                  80  
Val Asp Val Gln Gln Asn Asp Ser Ala Thr Tyr Thr Asn Val Ser Gly 
                85                  90                  95      
Asn Thr Ile Ser Glu Tyr Gln Arg Ser Leu Ala Thr Ser Val Ala Ile 
            100                 105                 110         
Glu Gly Arg Tyr Asn Phe Phe Ser Gly Ser Leu Ser Thr Asp Phe Asp 
        115                 120                 125             
Ser Asn Ser Leu Arg Asn Ala Glu Asn Glu Phe Thr Arg Ile Gln Gln 
    130                 135                 140                 
Ser Ile Asn Leu Trp Ser Leu Arg Leu Pro Ser Val Lys Ser Leu Arg 
145                 150                 155                 160 
Glu Leu Met Leu Pro His Met Arg Gln Gln Leu Asp Glu Leu Asn Val 
                165                 170                 175     
Asn Asp Pro Lys Ala Ile Ser Arg Tyr Phe Asp Arg Val Gly Ser His 
            180                 185                 190         
Phe Leu Thr Gly Ile Val Met Gly Gly Arg Ala Ile Leu Ala Ser Ser 
        195                 200                 205             
Thr Asn Lys Leu Arg Val Lys Arg Asp Tyr Ser Val Ser Val Val Ala 
    210                 215                 220                 
Lys Ala Ser Tyr Glu Gly Leu Thr Gly Gln Leu Ser Ala Glu Ala Lys 
225                 230                 235                 240 
Ala Lys Tyr Gly Glu Ser Ile Ser Ser Phe Thr Gln Tyr Ser Asn Thr 
                245                 250                 255     
His Gln Glu Val Arg Gly Gly Asp Gly Ala Lys Ala His Gly Val Phe 
            260                 265                 270         
Ser Gly Lys Lys Glu Asp Phe Gln Ala Trp Val Asp Ser Val Ser Ala 
        275                 280                 285             
Ser Pro Asp Phe Val Asp Phe Val Pro Thr Ile Pro Met Gln Glu Ile 
    290                 295                 300                 
Trp Thr Leu Cys Ser Ser Glu Ala Gln Ala Glu Ala Met Arg Lys His 
305                 310                 315                 320 
Phe Asp Asp Val Trp Ala Pro Ala Gln Ser Glu Lys Phe Arg Val Lys 
                325                 330                 335     
Ala Asn Tyr Ile Asp Gln Leu Val Val Ile Thr Gly Gly Ser Ser Thr 
            340                 345                 350         
Ile Glu Pro Pro Val Gly Tyr Ser Lys Ile Glu Tyr Asp Leu Asn Ala 
        355                 360                 365             
Gly Ala Gly Gly Asp Phe Ile Tyr Leu Cys Tyr His Glu Gln Thr Trp 
    370                 375                 380                 
Gln Ala Asp Arg Pro Lys Asp Ala Val Thr Asp Ile Arg Ile Ile Phe 
385                 390                 395                 400 
Asn Lys Glu Pro Thr Pro Pro Gly Tyr Thr Lys Leu Pro Gln Asp Leu 
                405                 410                 415     
Asn Lys Gly Ala Gly Gly Asp Asp Val Phe Leu Cys Tyr Lys Thr Glu 
            420                 425                 430         
Ala Tyr Asn Thr Asp Thr Ala Leu Asn Lys Val Thr Val Ile Gly Gly 
        435                 440                 445             
Asn Asn Ala Asp Ile Asn Ala Pro Phe Gly Tyr Leu Lys Val Pro Gly 
    450                 455                 460                 
Asp Leu Asn Arg Gly Ala Gly Gly Asn Phe Ile Tyr Ala Cys Thr Phe 
465                 470                 475                 480 
Val Gly Lys 
            

<210>  329
<211>  483
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  329
Met Glu Asn Ile Asp Leu Pro Gln Gly Leu Val Asn Phe Ser Thr Gln 
1               5                   10                  15      
His Leu Gln Leu Ile Arg Phe Lys Ala Gly Leu Asn Glu Thr Val Leu 
            20                  25                  30          
Pro Gly Val Glu Ala Ile Gly Leu Gly Tyr Asn Pro Phe Ile Ser Tyr 
        35                  40                  45              
Ala Ser Val Asn Ser Gly Ala Val Gln Leu Phe Asp Trp Ala Thr Ala 
    50                  55                  60                  
Lys Lys Arg Glu Val Pro Phe Lys Ala Gly Tyr Phe Val Pro Glu Leu 
65                  70                  75                  80  
Val Asp Val Gln Gln Asn Asp Ser Ala Thr Tyr Thr Asn Val Ser Gly 
                85                  90                  95      
Asn Thr Ile Ser Glu Tyr Gln Arg Ser Leu Ala Thr Ser Val Ala Ile 
            100                 105                 110         
Glu Gly Arg Tyr Asn Phe Phe Ser Gly Ser Leu Ser Thr Asp Phe Asp 
        115                 120                 125             
Ser Asn Ser Leu Arg Asn Ala Glu Asn Glu Phe Thr Arg Ile Gln Gln 
    130                 135                 140                 
Ser Ile Asn Leu Trp Ser Leu Arg Leu Pro Ser Val Lys Ser Leu Arg 
145                 150                 155                 160 
Glu Leu Met Leu Pro His Met Arg Gln Gln Leu Asp Glu Leu Asn Val 
                165                 170                 175     
Asn Asp Pro Lys Ala Ile Ser Arg Tyr Phe Asp Arg Val Gly Ser His 
            180                 185                 190         
Phe Leu Thr Gly Ile Val Met Gly Gly Arg Ala Ile Leu Ala Ser Ser 
        195                 200                 205             
Thr Asn Lys Leu Arg Val Lys Arg Asp Tyr Ser Val Ser Val Val Ala 
    210                 215                 220                 
Lys Ala Ser Tyr Glu Gly Leu Thr Gly Gln Leu Ser Ala Glu Ala Lys 
225                 230                 235                 240 
Ala Lys Tyr Gly Glu Ser Ile Ser Ser Phe Thr Gln Tyr Ser Asn Thr 
                245                 250                 255     
His Gln Glu Val Arg Gly Gly Asp Gly Ala Lys Ala His Gly Val Phe 
            260                 265                 270         
Ser Gly Lys Lys Glu Asp Phe Gln Ala Trp Val Asp Ser Val Ser Ala 
        275                 280                 285             
Ser Pro Asp Phe Val Asp Phe Val Pro Thr Ile Pro Met Gln Glu Ile 
    290                 295                 300                 
Trp Thr Leu Cys Ser Ser Glu Ala Gln Ala Glu Ala Met Arg Lys His 
305                 310                 315                 320 
Tyr Asp Asp Val Trp Ala Pro Ala Gln Ser Glu Lys Phe Arg Val Lys 
                325                 330                 335     
Ala Asn Tyr Ile Asp Gln Leu Val Val Ile Thr Gly Gly Ser Ser Thr 
            340                 345                 350         
Ile Glu Pro Pro Val Gly Tyr Ser Lys Ile Glu Tyr Asp Leu Asn Ala 
        355                 360                 365             
Gly Ala Gly Gly Asp Phe Ile Tyr Leu Cys Tyr His Glu Gln Thr Trp 
    370                 375                 380                 
Gln Ala Asp Arg Pro Lys Asp Ala Val Thr Asp Ile Arg Ile Ile Phe 
385                 390                 395                 400 
Asn Lys Glu Pro Thr Pro Pro Gly Tyr Thr Lys Leu Pro Gln Asp Leu 
                405                 410                 415     
Asn Lys Gly Ala Gly Gly Asp Asp Val Phe Leu Cys Tyr Lys Thr Glu 
            420                 425                 430         
Ala Tyr Asn Thr Asp Thr Ala Ile Asn Lys Val Thr Val Leu Gly Gly 
        435                 440                 445             
Asn Asn Ala Asp Ile Asn Ala Pro Tyr Gly Tyr Leu Lys Val Pro Gly 
    450                 455                 460                 
Asp Leu Asn Arg Gly Ala Gly Gly Asn Phe Ile Tyr Ala Cys Thr Phe 
465                 470                 475                 480 
Val Gly Lys 
            

<210>  330
<211>  483
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  330
Met Glu Asn Ile Asp Leu Pro Gln Gly Leu Val Asn Phe Ser Thr Gln 
1               5                   10                  15      
His Leu Gln Leu Ile Arg Phe Lys Ala Gly Leu Asn Glu Thr Val Leu 
            20                  25                  30          
Pro Gly Val Glu Ala Ile Gly Leu Gly Tyr Asn Pro Phe Ile Ser Tyr 
        35                  40                  45              
Ala Ser Val Asn Ser Gly Ala Val Gln Leu Phe Asp Trp Ala Thr Ala 
    50                  55                  60                  
Lys Lys Arg Glu Val Pro Phe Lys Ala Gly Tyr Phe Val Pro Glu Leu 
65                  70                  75                  80  
Val Asp Val Gln Gln Asn Asp Ser Ala Thr Phe Thr Asn Val Ser Gly 
                85                  90                  95      
Asn Thr Ile Ser Glu Tyr Gln Arg Ser Leu Ala Thr Ser Val Ala Ile 
            100                 105                 110         
Glu Gly Arg Tyr Asn Phe Phe Ser Gly Ser Leu Ser Thr Asp Phe Asp 
        115                 120                 125             
Ser Asn Ser Leu Arg Asn Ala Glu Asn Glu Phe Thr Arg Ile Gln Gln 
    130                 135                 140                 
Ser Ile Asn Leu Trp Ser Leu Arg Leu Pro Ser Val Lys Ser Leu Arg 
145                 150                 155                 160 
Glu Leu Met Leu Pro His Met Arg Gln Gln Leu Asp Glu Leu Asn Val 
                165                 170                 175     
Asn Asp Pro Lys Ala Ile Ser Arg Tyr Phe Asp Arg Val Gly Ser His 
            180                 185                 190         
Phe Leu Thr Gly Ile Val Met Gly Gly Arg Ala Ile Leu Ala Ser Ser 
        195                 200                 205             
Thr Asn Lys Leu Arg Val Lys Arg Asp Tyr Ser Val Ser Val Val Ala 
    210                 215                 220                 
Lys Ala Ser Tyr Glu Gly Leu Thr Gly Gln Leu Ser Ala Glu Ala Lys 
225                 230                 235                 240 
Ala Lys Tyr Gly Glu Ser Ile Ser Ser Phe Thr Gln Tyr Ser Asn Thr 
                245                 250                 255     
His Gln Glu Val Arg Gly Gly Asp Gly Ala Lys Ala His Gly Val Phe 
            260                 265                 270         
Ser Gly Lys Lys Glu Asp Phe Gln Ala Trp Val Asp Ser Val Ser Ala 
        275                 280                 285             
Ser Pro Asp Phe Val Asp Phe Val Pro Thr Ile Pro Met Gln Glu Ile 
    290                 295                 300                 
Trp Thr Leu Cys Ser Ser Glu Ala Gln Ala Glu Ala Met Arg Lys His 
305                 310                 315                 320 
Tyr Asp Asp Val Trp Ala Pro Ala Gln Ser Glu Lys Phe Arg Val Lys 
                325                 330                 335     
Ala Asn Tyr Ile Asp Gln Leu Val Val Ile Thr Gly Gly Ser Ser Thr 
            340                 345                 350         
Ile Glu Pro Pro Val Gly Tyr Ser Lys Ile Glu Tyr Asp Leu Asn Ala 
        355                 360                 365             
Gly Ala Gly Gly Asp Phe Ile Tyr Leu Cys Tyr His Glu Gln Thr Trp 
    370                 375                 380                 
Gln Ala Asp Arg Pro Lys Asp Ala Val Thr Asp Ile Arg Ile Ile Phe 
385                 390                 395                 400 
Asn Lys Glu Pro Thr Pro Pro Gly Tyr Thr Lys Leu Pro Gln Asp Leu 
                405                 410                 415     
Asn Lys Gly Ala Gly Gly Asp Asp Val Phe Leu Cys Tyr Lys Thr Glu 
            420                 425                 430         
Ala Tyr Asn Thr Asp Thr Ala Ile Asn Lys Val Thr Val Leu Gly Gly 
        435                 440                 445             
Asn Asn Ala Asp Ile Asn Ala Pro Tyr Gly Tyr Leu Lys Val Pro Gly 
    450                 455                 460                 
Asp Leu Asn Arg Gly Ala Gly Gly Asn Phe Ile Tyr Ala Cys Thr Phe 
465                 470                 475                 480 
Val Gly Lys 
            

<210>  331
<211>  483
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  331
Met Glu Asn Ile Asp Leu Pro Gln Gly Leu Val Asn Phe Ser Thr Gln 
1               5                   10                  15      
His Leu Gln Leu Ile Arg Phe Lys Ala Gly Leu Asn Glu Thr Val Leu 
            20                  25                  30          
Pro Gly Val Glu Ala Ile Gly Leu Gly Tyr Asn Pro Phe Ile Ser Tyr 
        35                  40                  45              
Ala Ser Val Asn Ser Gly Ala Val Gln Leu Phe Asp Trp Ala Thr Ala 
    50                  55                  60                  
Lys Lys Arg Glu Val Pro Phe Lys Ala Gly Tyr Phe Val Pro Glu Leu 
65                  70                  75                  80  
Val Asp Val Gln Gln Asn Asp Ser Ala Thr Tyr Thr Asn Val Ser Gly 
                85                  90                  95      
Asn Thr Ile Ser Glu Tyr Gln Arg Ser Leu Ala Thr Ser Val Ala Ile 
            100                 105                 110         
Glu Gly Arg Tyr Asn Phe Phe Ser Gly Ser Leu Ser Thr Asp Phe Asp 
        115                 120                 125             
Ser Asn Ser Leu Arg Asn Ala Glu Asn Glu Phe Thr Arg Ile Gln Gln 
    130                 135                 140                 
Ser Ile Asn Leu Trp Ser Leu Arg Leu Pro Ser Val Lys Ser Leu Arg 
145                 150                 155                 160 
Glu Leu Met Leu Pro His Met Arg Gln Gln Leu Asp Glu Leu Asn Val 
                165                 170                 175     
Asn Asp Pro Lys Ala Ile Ser Arg Tyr Phe Asp Arg Val Gly Ser His 
            180                 185                 190         
Phe Leu Thr Gly Ile Val Met Gly Gly Arg Ala Ile Leu Ala Ser Ser 
        195                 200                 205             
Thr Asn Lys Leu Arg Val Lys Arg Asp Tyr Ser Val Ser Val Val Ala 
    210                 215                 220                 
Lys Ala Ser Tyr Glu Gly Leu Thr Gly Gln Leu Ser Ala Glu Ala Lys 
225                 230                 235                 240 
Ala Lys Tyr Gly Glu Ser Ile Ser Ser Phe Thr Gln Tyr Ser Asn Thr 
                245                 250                 255     
His Gln Glu Val Arg Gly Gly Asp Gly Ala Lys Ala His Gly Val Phe 
            260                 265                 270         
Ser Gly Lys Lys Glu Asp Phe Gln Ala Trp Val Asp Ser Val Ser Ala 
        275                 280                 285             
Ser Pro Asp Phe Val Asp Phe Val Pro Thr Ile Pro Met Gln Glu Ile 
    290                 295                 300                 
Trp Thr Leu Cys Ser Ser Glu Ala Gln Ala Glu Ala Met Arg Lys His 
305                 310                 315                 320 
Tyr Asp Asp Val Trp Ala Pro Ala Gln Ser Glu Lys Tyr Arg Val Lys 
                325                 330                 335     
Ala Asn Tyr Leu Asp Gln Leu Val Val Ile Thr Gly Gly Ser Ser Thr 
            340                 345                 350         
Ile Glu Pro Pro Val Gly Tyr Ser Lys Ile Glu Tyr Asp Leu Asn Ala 
        355                 360                 365             
Gly Ala Gly Gly Asp Phe Ile Tyr Leu Cys Tyr His Glu Gln Thr Trp 
    370                 375                 380                 
Gln Ala Asp Arg Pro Lys Asp Ala Val Thr Asp Ile Arg Ile Ile Phe 
385                 390                 395                 400 
Asn Lys Glu Pro Thr Pro Pro Gly Tyr Thr Lys Leu Pro Gln Asp Leu 
                405                 410                 415     
Asn Lys Gly Ala Gly Gly Asp Asp Val Phe Leu Cys Tyr Lys Thr Glu 
            420                 425                 430         
Ala Tyr Asn Thr Asp Thr Ala Leu Asn Lys Val Thr Val Ile Gly Gly 
        435                 440                 445             
Asn Asn Ala Asp Ile Asn Ala Pro Tyr Gly Tyr Leu Lys Val Pro Gly 
    450                 455                 460                 
Asp Leu Asn Arg Gly Ala Gly Gly Asn Phe Ile Tyr Ala Cys Thr Phe 
465                 470                 475                 480 
Val Gly Lys 
            

<210>  332
<211>  483
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  332
Met Glu Asn Ile Asp Leu Pro Gln Gly Leu Val Asn Phe Ser Thr Gln 
1               5                   10                  15      
His Leu Gln Leu Ile Arg Phe Lys Ala Gly Leu Asn Glu Thr Val Leu 
            20                  25                  30          
Pro Gly Val Glu Ala Ile Gly Leu Gly Tyr Asn Pro Phe Ile Ser Tyr 
        35                  40                  45              
Ala Ser Val Asn Ser Gly Ala Val Gln Leu Phe Asp Trp Ala Thr Ala 
    50                  55                  60                  
Lys Lys Arg Glu Val Pro Phe Lys Ala Gly Tyr Phe Val Pro Glu Ile 
65                  70                  75                  80  
Val Asp Val Gln Gln Asn Asp Ser Ala Thr Phe Thr Asn Val Ser Gly 
                85                  90                  95      
Asn Thr Ile Ser Glu Tyr Gln Arg Ser Leu Ala Thr Ser Val Ala Ile 
            100                 105                 110         
Glu Gly Arg Tyr Asn Phe Phe Ser Gly Ser Leu Ser Thr Asp Phe Asp 
        115                 120                 125             
Ser Asn Ser Leu Arg Asn Ala Glu Asn Glu Phe Thr Arg Ile Gln Gln 
    130                 135                 140                 
Ser Ile Asn Leu Trp Ser Leu Arg Leu Pro Ser Val Lys Ser Leu Arg 
145                 150                 155                 160 
Glu Leu Met Leu Pro His Met Arg Gln Gln Leu Asp Glu Leu Asn Val 
                165                 170                 175     
Asn Asp Pro Lys Ala Ile Ser Arg Tyr Phe Asp Arg Val Gly Ser His 
            180                 185                 190         
Phe Leu Thr Gly Ile Val Met Gly Gly Arg Ala Ile Leu Ala Ser Ser 
        195                 200                 205             
Thr Asn Lys Leu Arg Val Lys Arg Asp Tyr Ser Val Ser Val Val Ala 
    210                 215                 220                 
Lys Ala Ser Tyr Glu Gly Leu Thr Gly Gln Leu Ser Ala Glu Ala Lys 
225                 230                 235                 240 
Ala Lys Tyr Gly Glu Ser Ile Ser Ser Phe Thr Gln Tyr Ser Asn Thr 
                245                 250                 255     
His Gln Glu Val Arg Gly Gly Asp Gly Ala Lys Ala His Gly Val Phe 
            260                 265                 270         
Ser Gly Lys Lys Glu Asp Phe Gln Ala Trp Val Asp Ser Val Ser Ala 
        275                 280                 285             
Ser Pro Asp Phe Val Asp Phe Val Pro Thr Ile Pro Met Gln Glu Ile 
    290                 295                 300                 
Trp Thr Leu Cys Ser Ser Glu Ala Gln Ala Glu Ala Met Arg Lys His 
305                 310                 315                 320 
Tyr Asp Asp Val Trp Ala Pro Ala Gln Ser Glu Lys Phe Arg Val Lys 
                325                 330                 335     
Ala Asn Tyr Ile Asp Gln Leu Val Val Leu Thr Gly Gly Ser Ser Thr 
            340                 345                 350         
Ile Glu Pro Pro Val Gly Tyr Ser Lys Ile Glu Tyr Asp Leu Asn Ala 
        355                 360                 365             
Gly Ala Gly Gly Asp Phe Ile Tyr Leu Cys Tyr His Glu Gln Thr Trp 
    370                 375                 380                 
Gln Ala Asp Arg Pro Lys Asp Ala Val Thr Asp Ile Arg Ile Ile Phe 
385                 390                 395                 400 
Asn Lys Glu Pro Thr Pro Pro Gly Tyr Thr Lys Leu Pro Gln Asp Leu 
                405                 410                 415     
Asn Lys Gly Ala Gly Gly Asp Asp Val Phe Leu Cys Tyr Lys Thr Glu 
            420                 425                 430         
Ala Phe Asn Thr Asp Thr Ala Ile Asn Lys Val Thr Val Ile Gly Gly 
        435                 440                 445             
Asn Asn Ala Asp Ile Asn Ala Pro Phe Gly Tyr Leu Lys Val Pro Gly 
    450                 455                 460                 
Asp Leu Asn Arg Gly Ala Gly Gly Asn Phe Ile Tyr Ala Cys Thr Phe 
465                 470                 475                 480 
Val Gly Lys 
            

<210>  333
<211>  483
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  333
Met Glu Asn Ile Asp Leu Pro Gln Gly Leu Val Asn Phe Ser Thr Gln 
1               5                   10                  15      
His Leu Gln Leu Ile Arg Phe Lys Ala Gly Leu Asn Glu Thr Val Leu 
            20                  25                  30          
Pro Gly Val Glu Ala Ile Gly Leu Gly Tyr Asn Pro Phe Ile Ser Tyr 
        35                  40                  45              
Ala Ser Val Asn Ser Gly Ala Val Gln Leu Phe Asp Trp Ala Thr Ala 
    50                  55                  60                  
Lys Lys Arg Glu Val Pro Phe Lys Ala Gly Tyr Phe Val Pro Glu Leu 
65                  70                  75                  80  
Val Asp Val Gln Gln Asn Asp Ser Ala Thr Phe Thr Asn Val Ser Gly 
                85                  90                  95      
Asn Thr Ile Ser Glu Tyr Gln Arg Ser Leu Ala Thr Ser Val Ala Ile 
            100                 105                 110         
Glu Gly Arg Tyr Asn Phe Phe Ser Gly Ser Leu Ser Thr Asp Phe Asp 
        115                 120                 125             
Ser Asn Ser Leu Arg Asn Ala Glu Asn Glu Phe Thr Arg Ile Gln Gln 
    130                 135                 140                 
Ser Ile Asn Leu Trp Ser Leu Arg Leu Pro Ser Val Lys Ser Leu Arg 
145                 150                 155                 160 
Glu Leu Met Leu Pro His Met Arg Gln Gln Leu Asp Glu Leu Asn Val 
                165                 170                 175     
Asn Asp Pro Lys Ala Ile Ser Arg Tyr Phe Asp Arg Val Gly Ser His 
            180                 185                 190         
Phe Leu Thr Gly Ile Val Met Gly Gly Arg Ala Ile Leu Ala Ser Ser 
        195                 200                 205             
Thr Asn Lys Leu Arg Val Lys Arg Asp Tyr Ser Val Ser Val Val Ala 
    210                 215                 220                 
Lys Ala Ser Tyr Glu Gly Leu Thr Gly Gln Leu Ser Ala Glu Ala Lys 
225                 230                 235                 240 
Ala Lys Tyr Gly Glu Ser Ile Ser Ser Phe Thr Gln Tyr Ser Asn Thr 
                245                 250                 255     
His Gln Glu Val Arg Gly Gly Asp Gly Ala Lys Ala His Gly Val Phe 
            260                 265                 270         
Ser Gly Lys Lys Glu Asp Phe Gln Ala Trp Val Asp Ser Val Ser Ala 
        275                 280                 285             
Ser Pro Asp Phe Val Asp Phe Val Pro Thr Ile Pro Met Gln Glu Ile 
    290                 295                 300                 
Trp Thr Leu Cys Ser Ser Glu Ala Gln Ala Glu Ala Met Arg Lys His 
305                 310                 315                 320 
Tyr Asp Asp Val Trp Ala Pro Ala Gln Ser Glu Lys Tyr Arg Val Lys 
                325                 330                 335     
Ala Asn Phe Ile Asp Gln Leu Val Val Leu Thr Gly Gly Ser Ser Thr 
            340                 345                 350         
Ile Glu Pro Pro Val Gly Tyr Ser Lys Ile Glu Tyr Asp Leu Asn Ala 
        355                 360                 365             
Gly Ala Gly Gly Asp Phe Ile Tyr Leu Cys Tyr His Glu Gln Thr Trp 
    370                 375                 380                 
Gln Ala Asp Arg Pro Lys Asp Ala Val Thr Asp Ile Arg Ile Ile Phe 
385                 390                 395                 400 
Asn Lys Glu Pro Thr Pro Pro Gly Tyr Thr Lys Leu Pro Gln Asp Leu 
                405                 410                 415     
Asn Lys Gly Ala Gly Gly Asp Asp Val Phe Leu Cys Tyr Lys Thr Glu 
            420                 425                 430         
Ala Phe Asn Thr Asp Thr Ala Ile Asn Lys Val Thr Val Ile Gly Gly 
        435                 440                 445             
Asn Asn Ala Asp Ile Asn Ala Pro Tyr Gly Tyr Leu Lys Val Pro Gly 
    450                 455                 460                 
Asp Leu Asn Arg Gly Ala Gly Gly Asn Phe Ile Tyr Ala Cys Thr Phe 
465                 470                 475                 480 
Val Gly Lys 
            

<210>  334
<211>  483
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  334
Met Glu Asn Ile Asp Leu Pro Gln Gly Leu Val Asn Phe Ser Thr Gln 
1               5                   10                  15      
His Leu Gln Leu Ile Arg Phe Lys Ala Gly Leu Asn Glu Thr Val Leu 
            20                  25                  30          
Pro Gly Val Glu Ala Ile Gly Leu Gly Tyr Asn Pro Phe Ile Ser Tyr 
        35                  40                  45              
Ala Ser Val Asn Ser Gly Ala Val Gln Leu Phe Asp Trp Ala Thr Ala 
    50                  55                  60                  
Lys Lys Arg Glu Val Pro Phe Lys Ala Gly Tyr Phe Val Pro Glu Leu 
65                  70                  75                  80  
Val Asp Val Gln Gln Asn Asp Ser Ala Thr Tyr Thr Asn Val Ser Gly 
                85                  90                  95      
Asn Thr Leu Ser Glu Tyr Gln Arg Ser Leu Ala Thr Ser Val Ala Ile 
            100                 105                 110         
Glu Gly Arg Tyr Asn Phe Phe Ser Gly Ser Leu Ser Thr Asp Phe Asp 
        115                 120                 125             
Ser Asn Ser Leu Arg Asn Ala Glu Asn Glu Phe Thr Arg Ile Gln Gln 
    130                 135                 140                 
Ser Ile Asn Leu Trp Ser Leu Arg Leu Pro Ser Val Lys Ser Leu Arg 
145                 150                 155                 160 
Glu Leu Met Leu Pro His Met Arg Gln Gln Leu Asp Glu Leu Asn Val 
                165                 170                 175     
Asn Asp Pro Lys Ala Ile Ser Arg Tyr Phe Asp Arg Val Gly Ser His 
            180                 185                 190         
Phe Leu Thr Gly Ile Val Met Gly Gly Arg Ala Ile Leu Ala Ser Ser 
        195                 200                 205             
Thr Asn Lys Leu Arg Val Lys Arg Asp Tyr Ser Val Ser Val Val Ala 
    210                 215                 220                 
Lys Ala Ser Tyr Glu Gly Leu Thr Gly Gln Leu Ser Ala Glu Ala Lys 
225                 230                 235                 240 
Ala Lys Tyr Gly Glu Ser Ile Ser Ser Phe Thr Gln Tyr Ser Asn Thr 
                245                 250                 255     
His Gln Glu Val Arg Gly Gly Asp Gly Ala Lys Ala His Gly Val Phe 
            260                 265                 270         
Ser Gly Lys Lys Glu Asp Phe Gln Ala Trp Val Asp Ser Val Ser Ala 
        275                 280                 285             
Ser Pro Asp Phe Val Asp Phe Val Pro Thr Ile Pro Met Gln Glu Ile 
    290                 295                 300                 
Trp Thr Leu Cys Ser Ser Glu Ala Gln Ala Glu Ala Met Arg Lys His 
305                 310                 315                 320 
Tyr Asp Asp Val Trp Ala Pro Ala Gln Ser Glu Lys Phe Arg Val Lys 
                325                 330                 335     
Ala Asn Tyr Ile Asp Gln Leu Val Val Ile Thr Gly Gly Ser Ser Thr 
            340                 345                 350         
Ile Glu Pro Pro Val Gly Tyr Ser Lys Leu Glu Tyr Asp Leu Asn Ala 
        355                 360                 365             
Gly Ala Gly Gly Asp Phe Ile Tyr Leu Cys Tyr His Glu Gln Thr Trp 
    370                 375                 380                 
Gln Ala Asp Arg Pro Lys Asp Ala Val Thr Asp Ile Arg Ile Ile Phe 
385                 390                 395                 400 
Asn Lys Glu Pro Thr Pro Pro Gly Tyr Thr Lys Leu Pro Gln Asp Leu 
                405                 410                 415     
Asn Lys Gly Ala Gly Gly Asp Asp Val Phe Leu Cys Tyr Lys Thr Glu 
            420                 425                 430         
Ala Phe Asn Thr Asp Thr Ala Ile Asn Lys Val Thr Val Ile Gly Gly 
        435                 440                 445             
Asn Asn Ala Asp Ile Asn Ala Pro Tyr Gly Tyr Leu Lys Val Pro Gly 
    450                 455                 460                 
Asp Leu Asn Arg Gly Ala Gly Gly Asn Phe Ile Tyr Ala Cys Thr Phe 
465                 470                 475                 480 
Val Gly Lys 
            

<210>  335
<211>  483
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  335
Met Glu Asn Ile Asp Leu Pro Gln Gly Leu Val Asn Phe Ser Thr Gln 
1               5                   10                  15      
His Leu Gln Leu Ile Arg Phe Lys Ala Gly Leu Asn Glu Thr Val Leu 
            20                  25                  30          
Pro Gly Val Glu Ala Ile Gly Leu Gly Tyr Asn Pro Phe Ile Ser Tyr 
        35                  40                  45              
Ala Ser Val Asn Ser Gly Ala Val Gln Leu Phe Asp Trp Ala Thr Ala 
    50                  55                  60                  
Lys Lys Arg Glu Val Pro Phe Lys Ala Gly Tyr Phe Val Pro Glu Leu 
65                  70                  75                  80  
Val Asp Val Gln Gln Asn Asp Ser Ala Thr Phe Thr Asn Val Ser Gly 
                85                  90                  95      
Asn Thr Ile Ser Glu Tyr Gln Arg Ser Leu Ala Thr Ser Val Ala Ile 
            100                 105                 110         
Glu Gly Arg Tyr Asn Phe Phe Ser Gly Ser Leu Ser Thr Asp Phe Asp 
        115                 120                 125             
Ser Asn Ser Leu Arg Asn Ala Glu Asn Glu Phe Thr Arg Ile Gln Gln 
    130                 135                 140                 
Ser Ile Asn Leu Trp Ser Leu Arg Leu Pro Ser Val Lys Ser Leu Arg 
145                 150                 155                 160 
Glu Leu Met Leu Pro His Met Arg Gln Gln Leu Asp Glu Leu Asn Val 
                165                 170                 175     
Asn Asp Pro Lys Ala Ile Ser Arg Tyr Phe Asp Arg Val Gly Ser His 
            180                 185                 190         
Phe Leu Thr Gly Ile Val Met Gly Gly Arg Ala Ile Leu Ala Ser Ser 
        195                 200                 205             
Thr Asn Lys Leu Arg Val Lys Arg Asp Tyr Ser Val Ser Val Val Ala 
    210                 215                 220                 
Lys Ala Ser Tyr Glu Gly Leu Thr Gly Gln Leu Ser Ala Glu Ala Lys 
225                 230                 235                 240 
Ala Lys Tyr Gly Glu Ser Ile Ser Ser Phe Thr Gln Tyr Ser Asn Thr 
                245                 250                 255     
His Gln Glu Val Arg Gly Gly Asp Gly Ala Lys Ala His Gly Val Phe 
            260                 265                 270         
Ser Gly Lys Lys Glu Asp Phe Gln Ala Trp Val Asp Ser Val Ser Ala 
        275                 280                 285             
Ser Pro Asp Phe Val Asp Phe Val Pro Thr Ile Pro Met Gln Glu Ile 
    290                 295                 300                 
Trp Thr Leu Cys Ser Ser Glu Ala Gln Ala Glu Ala Met Arg Lys His 
305                 310                 315                 320 
Tyr Asp Asp Val Trp Ala Pro Ala Gln Ser Glu Lys Phe Arg Val Lys 
                325                 330                 335     
Ala Asn Tyr Ile Asp Gln Leu Val Val Ile Thr Gly Gly Ser Ser Thr 
            340                 345                 350         
Ile Glu Pro Pro Val Gly Tyr Ser Lys Ile Glu Tyr Asp Leu Asn Ala 
        355                 360                 365             
Gly Ala Gly Gly Asp Phe Ile Tyr Leu Cys Tyr His Glu Gln Thr Trp 
    370                 375                 380                 
Gln Ala Asp Arg Pro Lys Asp Ala Val Thr Asp Ile Arg Ile Ile Phe 
385                 390                 395                 400 
Asn Lys Glu Pro Thr Pro Pro Gly Tyr Thr Lys Leu Pro Gln Asp Leu 
                405                 410                 415     
Asn Lys Gly Ala Gly Gly Asp Asp Val Phe Leu Cys Tyr Lys Thr Glu 
            420                 425                 430         
Ala Tyr Asn Thr Asp Thr Ala Ile Asn Lys Val Thr Val Ile Gly Gly 
        435                 440                 445             
Asn Asn Ala Asp Ile Asn Ala Pro Tyr Gly Tyr Leu Lys Val Pro Gly 
    450                 455                 460                 
Asp Leu Asn Arg Gly Ala Gly Gly Asn Phe Ile Tyr Ala Cys Thr Phe 
465                 470                 475                 480 
Val Gly Lys 
            

<210>  336
<211>  483
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  336
Met Glu Asn Ile Asp Leu Pro Gln Gly Leu Val Asn Phe Ser Thr Gln 
1               5                   10                  15      
His Leu Gln Leu Ile Arg Phe Lys Ala Gly Leu Asn Glu Thr Val Leu 
            20                  25                  30          
Pro Gly Val Glu Ala Ile Gly Leu Gly Tyr Asn Pro Phe Ile Ser Tyr 
        35                  40                  45              
Ala Ser Val Asn Ser Gly Ala Val Gln Leu Phe Asp Trp Ala Thr Ala 
    50                  55                  60                  
Lys Lys Arg Glu Val Pro Phe Lys Ala Gly Tyr Phe Val Pro Glu Leu 
65                  70                  75                  80  
Val Asp Val Gln Gln Asn Asp Ser Ala Thr Phe Thr Asn Val Ser Gly 
                85                  90                  95      
Asn Thr Leu Ser Glu Tyr Gln Arg Ser Leu Ala Thr Ser Val Ala Ile 
            100                 105                 110         
Glu Gly Arg Tyr Asn Phe Phe Ser Gly Ser Leu Ser Thr Asp Phe Asp 
        115                 120                 125             
Ser Asn Ser Leu Arg Asn Ala Glu Asn Glu Phe Thr Arg Ile Gln Gln 
    130                 135                 140                 
Ser Ile Asn Leu Trp Ser Leu Arg Leu Pro Ser Val Lys Ser Leu Arg 
145                 150                 155                 160 
Glu Leu Met Leu Pro His Met Arg Gln Gln Leu Asp Glu Leu Asn Val 
                165                 170                 175     
Asn Asp Pro Lys Ala Ile Ser Arg Tyr Phe Asp Arg Val Gly Ser His 
            180                 185                 190         
Phe Leu Thr Gly Ile Val Met Gly Gly Arg Ala Ile Leu Ala Ser Ser 
        195                 200                 205             
Thr Asn Lys Leu Arg Val Lys Arg Asp Tyr Ser Val Ser Val Val Ala 
    210                 215                 220                 
Lys Ala Ser Tyr Glu Gly Leu Thr Gly Gln Leu Ser Ala Glu Ala Lys 
225                 230                 235                 240 
Ala Lys Tyr Gly Glu Ser Ile Ser Ser Phe Thr Gln Tyr Ser Asn Thr 
                245                 250                 255     
His Gln Glu Val Arg Gly Gly Asp Gly Ala Lys Ala His Gly Val Phe 
            260                 265                 270         
Ser Gly Lys Lys Glu Asp Phe Gln Ala Trp Val Asp Ser Val Ser Ala 
        275                 280                 285             
Ser Pro Asp Phe Val Asp Phe Val Pro Thr Ile Pro Met Gln Glu Ile 
    290                 295                 300                 
Trp Thr Leu Cys Ser Ser Glu Ala Gln Ala Glu Ala Met Arg Lys His 
305                 310                 315                 320 
Tyr Asp Asp Val Trp Ala Pro Ala Gln Ser Glu Lys Phe Arg Val Lys 
                325                 330                 335     
Ala Asn Phe Ile Asp Gln Leu Val Val Leu Thr Gly Gly Ser Ser Thr 
            340                 345                 350         
Leu Glu Pro Pro Val Gly Tyr Ser Lys Leu Glu Tyr Asp Leu Asn Ala 
        355                 360                 365             
Gly Ala Gly Gly Asp Phe Ile Tyr Leu Cys Tyr His Glu Gln Thr Trp 
    370                 375                 380                 
Gln Ala Asp Arg Pro Lys Asp Ala Val Thr Asp Ile Arg Ile Ile Phe 
385                 390                 395                 400 
Asn Lys Glu Pro Thr Pro Pro Gly Tyr Thr Lys Leu Pro Gln Asp Leu 
                405                 410                 415     
Asn Lys Gly Ala Gly Gly Asp Asp Val Phe Leu Cys Tyr Lys Thr Glu 
            420                 425                 430         
Ala Tyr Asn Thr Asp Thr Ala Leu Asn Lys Val Thr Val Ile Gly Gly 
        435                 440                 445             
Asn Asn Ala Asp Ile Asn Ala Pro Tyr Gly Tyr Leu Lys Val Pro Gly 
    450                 455                 460                 
Asp Leu Asn Arg Gly Ala Gly Gly Asn Phe Ile Tyr Ala Cys Thr Phe 
465                 470                 475                 480 
Val Gly Lys 
            

<210>  337
<211>  483
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  337
Met Glu Asn Ile Asp Leu Pro Gln Gly Leu Val Asn Phe Ser Thr Gln 
1               5                   10                  15      
His Leu Gln Leu Ile Arg Phe Lys Ala Gly Leu Asn Glu Thr Val Leu 
            20                  25                  30          
Pro Gly Val Glu Ala Ile Gly Leu Gly Tyr Asn Pro Phe Ile Ser Tyr 
        35                  40                  45              
Ala Ser Val Asn Ser Gly Ala Val Gln Leu Phe Asp Trp Ala Thr Ala 
    50                  55                  60                  
Lys Lys Arg Glu Val Pro Phe Lys Ala Gly Tyr Phe Val Pro Glu Leu 
65                  70                  75                  80  
Val Asp Val Gln Gln Asn Asp Ser Ala Thr Phe Thr Asn Val Ser Gly 
                85                  90                  95      
Asn Thr Leu Ser Glu Tyr Gln Arg Ser Leu Ala Thr Ser Val Ala Ile 
            100                 105                 110         
Glu Gly Arg Tyr Asn Phe Phe Ser Gly Ser Leu Ser Thr Asp Phe Asp 
        115                 120                 125             
Ser Asn Ser Leu Arg Asn Ala Glu Asn Glu Phe Thr Arg Ile Gln Gln 
    130                 135                 140                 
Ser Ile Asn Leu Trp Ser Leu Arg Leu Pro Ser Val Lys Ser Leu Arg 
145                 150                 155                 160 
Glu Leu Met Leu Pro His Met Arg Gln Gln Leu Asp Glu Leu Asn Val 
                165                 170                 175     
Asn Asp Pro Lys Ala Ile Ser Arg Tyr Phe Asp Arg Val Gly Ser His 
            180                 185                 190         
Phe Leu Thr Gly Ile Val Met Gly Gly Arg Ala Ile Leu Ala Ser Ser 
        195                 200                 205             
Thr Asn Lys Leu Arg Val Lys Arg Asp Tyr Ser Val Ser Val Val Ala 
    210                 215                 220                 
Lys Ala Ser Tyr Glu Gly Leu Thr Gly Gln Leu Ser Ala Glu Ala Lys 
225                 230                 235                 240 
Ala Lys Tyr Gly Glu Ser Ile Ser Ser Phe Thr Gln Tyr Ser Asn Thr 
                245                 250                 255     
His Gln Glu Val Arg Gly Gly Asp Gly Ala Lys Ala His Gly Val Phe 
            260                 265                 270         
Ser Gly Lys Lys Glu Asp Phe Gln Ala Trp Val Asp Ser Val Ser Ala 
        275                 280                 285             
Ser Pro Asp Phe Val Asp Phe Val Pro Thr Ile Pro Met Gln Glu Ile 
    290                 295                 300                 
Trp Thr Leu Cys Ser Ser Glu Ala Gln Ala Glu Ala Met Arg Lys His 
305                 310                 315                 320 
Phe Asp Asp Val Trp Ala Pro Ala Gln Ser Glu Lys Phe Arg Val Lys 
                325                 330                 335     
Ala Asn Phe Ile Asp Gln Leu Val Val Leu Thr Gly Gly Ser Ser Thr 
            340                 345                 350         
Ile Glu Pro Pro Val Gly Tyr Ser Lys Ile Glu Tyr Asp Leu Asn Ala 
        355                 360                 365             
Gly Ala Gly Gly Asp Phe Ile Tyr Leu Cys Tyr His Glu Gln Thr Trp 
    370                 375                 380                 
Gln Ala Asp Arg Pro Lys Asp Ala Val Thr Asp Ile Arg Ile Ile Phe 
385                 390                 395                 400 
Asn Lys Glu Pro Thr Pro Pro Gly Tyr Thr Lys Leu Pro Gln Asp Leu 
                405                 410                 415     
Asn Lys Gly Ala Gly Gly Asp Asp Val Phe Leu Cys Tyr Lys Thr Glu 
            420                 425                 430         
Ala Phe Asn Thr Asp Thr Ala Ile Asn Lys Val Thr Val Ile Gly Gly 
        435                 440                 445             
Asn Asn Ala Asp Leu Asn Ala Pro Tyr Gly Tyr Leu Lys Val Pro Gly 
    450                 455                 460                 
Asp Leu Asn Arg Gly Ala Gly Gly Asn Phe Ile Tyr Ala Cys Thr Phe 
465                 470                 475                 480 
Val Gly Lys 
            

<210>  338
<211>  483
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  338
Met Glu Asn Ile Asp Leu Pro Gln Gly Leu Val Asn Phe Ser Thr Gln 
1               5                   10                  15      
His Leu Gln Leu Ile Arg Phe Lys Ala Gly Leu Asn Glu Thr Val Leu 
            20                  25                  30          
Pro Gly Val Glu Ala Ile Gly Leu Gly Tyr Asn Pro Phe Ile Ser Tyr 
        35                  40                  45              
Ala Ser Val Asn Ser Gly Ala Val Gln Leu Phe Asp Trp Ala Thr Ala 
    50                  55                  60                  
Lys Lys Arg Glu Val Pro Phe Lys Ala Gly Tyr Phe Val Pro Glu Leu 
65                  70                  75                  80  
Val Asp Val Gln Gln Asn Asp Ser Ala Thr Tyr Thr Asn Val Ser Gly 
                85                  90                  95      
Asn Thr Ile Ser Glu Tyr Gln Arg Ser Leu Ala Thr Ser Val Ala Ile 
            100                 105                 110         
Glu Gly Arg Tyr Asn Phe Phe Ser Gly Ser Leu Ser Thr Asp Phe Asp 
        115                 120                 125             
Ser Asn Ser Leu Arg Asn Ala Glu Asn Glu Phe Thr Arg Ile Gln Gln 
    130                 135                 140                 
Ser Ile Asn Leu Trp Ser Leu Arg Leu Pro Ser Val Lys Ser Leu Arg 
145                 150                 155                 160 
Glu Leu Met Leu Pro His Met Arg Gln Gln Leu Asp Glu Leu Asn Val 
                165                 170                 175     
Asn Asp Pro Lys Ala Ile Ser Arg Tyr Phe Asp Arg Val Gly Ser His 
            180                 185                 190         
Phe Leu Thr Gly Ile Val Met Gly Gly Arg Ala Ile Leu Ala Ser Ser 
        195                 200                 205             
Thr Asn Lys Leu Arg Val Lys Arg Asp Tyr Ser Val Ser Val Val Ala 
    210                 215                 220                 
Lys Ala Ser Tyr Glu Gly Leu Thr Gly Gln Leu Ser Ala Glu Ala Lys 
225                 230                 235                 240 
Ala Lys Tyr Gly Glu Ser Ile Ser Ser Phe Thr Gln Tyr Ser Asn Thr 
                245                 250                 255     
His Gln Glu Val Arg Gly Gly Asp Gly Ala Lys Ala His Gly Val Phe 
            260                 265                 270         
Ser Gly Lys Lys Glu Asp Phe Gln Ala Trp Val Asp Ser Val Ser Ala 
        275                 280                 285             
Ser Pro Asp Phe Val Asp Phe Val Pro Thr Ile Pro Met Gln Glu Ile 
    290                 295                 300                 
Trp Thr Leu Cys Ser Ser Glu Ala Gln Ala Glu Ala Met Arg Lys His 
305                 310                 315                 320 
Phe Asp Asp Val Trp Ala Pro Ala Gln Ser Glu Lys Phe Arg Val Lys 
                325                 330                 335     
Ala Asn Tyr Ile Asp Gln Leu Val Val Ile Thr Gly Gly Ser Ser Thr 
            340                 345                 350         
Ile Glu Pro Pro Val Gly Tyr Ser Lys Ile Glu Tyr Asp Leu Asn Ala 
        355                 360                 365             
Gly Ala Gly Gly Asp Phe Ile Tyr Leu Cys Tyr His Glu Gln Thr Trp 
    370                 375                 380                 
Gln Ala Asp Arg Pro Lys Asp Ala Val Thr Asp Ile Arg Ile Ile Phe 
385                 390                 395                 400 
Asn Lys Glu Pro Thr Pro Pro Gly Tyr Thr Lys Leu Pro Gln Asp Leu 
                405                 410                 415     
Asn Lys Gly Ala Gly Gly Asp Asp Val Phe Leu Cys Tyr Lys Thr Glu 
            420                 425                 430         
Ala Phe Asn Thr Asp Thr Ala Ile Asn Lys Val Thr Val Leu Gly Gly 
        435                 440                 445             
Asn Asn Ala Asp Ile Asn Ala Pro Tyr Gly Tyr Leu Lys Val Pro Gly 
    450                 455                 460                 
Asp Leu Asn Arg Gly Ala Gly Gly Asn Phe Ile Tyr Ala Cys Thr Phe 
465                 470                 475                 480 
Val Gly Lys 
            

<210>  339
<211>  483
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  339
Met Glu Asn Ile Asp Leu Pro Gln Gly Leu Val Asn Phe Ser Thr Gln 
1               5                   10                  15      
His Leu Gln Leu Ile Arg Phe Lys Ala Gly Leu Asn Glu Thr Val Leu 
            20                  25                  30          
Pro Gly Val Glu Ala Ile Gly Leu Gly Tyr Asn Pro Phe Ile Ser Tyr 
        35                  40                  45              
Ala Ser Val Asn Ser Gly Ala Val Gln Leu Phe Asp Trp Ala Thr Ala 
    50                  55                  60                  
Lys Lys Arg Glu Val Pro Phe Lys Ala Gly Tyr Phe Val Pro Glu Leu 
65                  70                  75                  80  
Val Asp Val Gln Gln Asn Asp Ser Ala Thr Phe Thr Asn Val Ser Gly 
                85                  90                  95      
Asn Thr Ile Ser Glu Tyr Gln Arg Ser Leu Ala Thr Ser Val Ala Ile 
            100                 105                 110         
Glu Gly Arg Tyr Asn Phe Phe Ser Gly Ser Leu Ser Thr Asp Phe Asp 
        115                 120                 125             
Ser Asn Ser Leu Arg Asn Ala Glu Asn Glu Phe Thr Arg Ile Gln Gln 
    130                 135                 140                 
Ser Ile Asn Leu Trp Ser Leu Arg Leu Pro Ser Val Lys Ser Leu Arg 
145                 150                 155                 160 
Glu Leu Met Leu Pro His Met Arg Gln Gln Leu Asp Glu Leu Asn Val 
                165                 170                 175     
Asn Asp Pro Lys Ala Ile Ser Arg Tyr Phe Asp Arg Val Gly Ser His 
            180                 185                 190         
Phe Leu Thr Gly Ile Val Met Gly Gly Arg Ala Ile Leu Ala Ser Ser 
        195                 200                 205             
Thr Asn Lys Leu Arg Val Lys Arg Asp Tyr Ser Val Ser Val Val Ala 
    210                 215                 220                 
Lys Ala Ser Tyr Glu Gly Leu Thr Gly Gln Leu Ser Ala Glu Thr Lys 
225                 230                 235                 240 
Ala Lys Tyr Gly Glu Ser Ile Ser Ser Phe Thr Gln Tyr Ser Asn Thr 
                245                 250                 255     
His Gln Glu Val Arg Gly Gly Asp Gly Ala Lys Ala His Gly Val Phe 
            260                 265                 270         
Ser Gly Lys Lys Glu Asp Phe Gln Ala Trp Val Asp Ser Val Ser Ala 
        275                 280                 285             
Ser Pro Asp Phe Val Asp Phe Val Pro Thr Ile Pro Met Gln Glu Ile 
    290                 295                 300                 
Trp Thr Leu Cys Ser Ser Glu Ala Gln Ala Glu Ala Met Arg Lys His 
305                 310                 315                 320 
Tyr Asp Asp Val Trp Ala Pro Ala Gln Ser Glu Lys Tyr Arg Val Lys 
                325                 330                 335     
Ala Asn Phe Ile Asp Gln Leu Val Val Ile Thr Gly Gly Ser Ser Thr 
            340                 345                 350         
Ile Glu Pro Pro Val Gly Tyr Ser Lys Ile Glu Tyr Asp Leu Asn Ala 
        355                 360                 365             
Gly Ala Gly Gly Asp Phe Ile Tyr Leu Cys Tyr His Glu Gln Thr Trp 
    370                 375                 380                 
Gln Ala Asp Arg Pro Lys Asp Ala Val Thr Asp Ile Arg Ile Ile Phe 
385                 390                 395                 400 
Asn Lys Glu Pro Thr Pro Pro Gly Tyr Thr Lys Leu Pro Gln Asp Leu 
                405                 410                 415     
Asn Lys Gly Ala Gly Gly Asp Asp Val Phe Leu Cys Tyr Lys Thr Glu 
            420                 425                 430         
Ala Tyr Asn Thr Asp Thr Ala Ile Asn Lys Val Thr Val Ile Gly Gly 
        435                 440                 445             
Asn Asn Ala Asp Leu Asn Ala Pro Tyr Gly Tyr Leu Lys Val Pro Gly 
    450                 455                 460                 
Asp Leu Asn Arg Gly Ala Gly Gly Asn Phe Ile Tyr Ala Cys Thr Phe 
465                 470                 475                 480 
Val Gly Lys 
            

<210>  340
<211>  483
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  340
Met Glu Asn Ile Asp Leu Pro Gln Gly Leu Val Asn Phe Ser Thr Gln 
1               5                   10                  15      
His Leu Gln Leu Ile Arg Phe Lys Ala Gly Leu Asn Glu Thr Val Leu 
            20                  25                  30          
Pro Gly Val Glu Ala Ile Gly Leu Gly Tyr Asn Pro Phe Ile Ser Tyr 
        35                  40                  45              
Ala Ser Val Asn Ser Gly Ala Val Gln Leu Phe Asp Trp Ala Thr Ala 
    50                  55                  60                  
Lys Lys Arg Glu Val Pro Phe Lys Ala Gly Tyr Phe Val Pro Glu Leu 
65                  70                  75                  80  
Val Asp Val Gln Gln Asn Asp Ser Ala Thr Tyr Thr Asn Val Ser Gly 
                85                  90                  95      
Asn Thr Ile Ser Glu Tyr Gln Arg Ser Leu Ala Thr Ser Val Ala Ile 
            100                 105                 110         
Glu Gly Arg Tyr Asn Phe Phe Ser Gly Ser Leu Ser Thr Asp Phe Asp 
        115                 120                 125             
Ser Asn Ser Leu Arg Asn Ala Glu Asn Glu Phe Thr Arg Ile Gln Gln 
    130                 135                 140                 
Ser Ile Asn Leu Trp Ser Leu Arg Leu Pro Ser Val Lys Ser Leu Arg 
145                 150                 155                 160 
Glu Leu Met Leu Pro His Met Arg Gln Gln Leu Asp Glu Leu Asn Val 
                165                 170                 175     
Asn Asp Pro Lys Ala Ile Ser Arg Tyr Phe Asp Arg Val Gly Ser His 
            180                 185                 190         
Phe Leu Thr Gly Ile Val Met Gly Gly Arg Ala Ile Leu Ala Ser Ser 
        195                 200                 205             
Thr Asn Lys Leu Arg Val Lys Arg Asp Tyr Ser Val Ser Val Val Ala 
    210                 215                 220                 
Lys Ala Ser Tyr Glu Gly Leu Thr Gly Gln Leu Ser Ala Glu Ala Lys 
225                 230                 235                 240 
Ala Lys Tyr Gly Glu Ser Ile Ser Ser Phe Thr Gln Tyr Ser Asn Thr 
                245                 250                 255     
His Gln Glu Val Arg Gly Gly Asp Gly Ala Lys Ala His Gly Val Phe 
            260                 265                 270         
Ser Gly Lys Lys Glu Asp Phe Gln Ala Trp Val Asp Ser Val Ser Ala 
        275                 280                 285             
Ser Pro Asp Phe Val Asp Phe Val Pro Thr Ile Pro Met Gln Glu Ile 
    290                 295                 300                 
Trp Thr Leu Cys Ser Ser Glu Ala Gln Ala Glu Ala Met Arg Lys His 
305                 310                 315                 320 
Tyr Asp Asp Val Trp Ala Pro Ala Gln Ser Glu Lys Phe Arg Val Lys 
                325                 330                 335     
Ala Asn Tyr Ile Asp Gln Leu Val Val Ile Thr Gly Gly Ser Ser Thr 
            340                 345                 350         
Ile Glu Pro Pro Val Gly Tyr Ser Lys Ile Glu Tyr Asp Leu Asn Ala 
        355                 360                 365             
Gly Ala Gly Gly Asp Phe Ile Tyr Leu Cys Tyr His Glu Gln Thr Trp 
    370                 375                 380                 
Gln Ala Asp Arg Pro Lys Asp Ala Val Thr Asp Ile Arg Ile Ile Phe 
385                 390                 395                 400 
Asn Lys Glu Pro Thr Pro Pro Gly Tyr Thr Lys Leu Pro Gln Asp Leu 
                405                 410                 415     
Asn Lys Gly Ala Gly Gly Asp Asp Val Phe Leu Cys Tyr Lys Thr Glu 
            420                 425                 430         
Ala Phe Asn Thr Asp Thr Ala Ile Asn Lys Val Thr Val Ile Gly Gly 
        435                 440                 445             
Asn Asn Ala Asp Ile Asn Ala Pro Phe Gly Tyr Leu Lys Val Pro Gly 
    450                 455                 460                 
Asp Leu Asn Arg Gly Ala Gly Gly Asn Phe Ile Tyr Ala Cys Thr Phe 
465                 470                 475                 480 
Val Gly Lys 
            

<210>  341
<211>  483
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  341
Met Glu Asn Ile Asp Leu Pro Gln Gly Leu Val Asn Phe Ser Thr Gln 
1               5                   10                  15      
His Leu Gln Leu Ile Arg Phe Lys Ala Gly Leu Asn Glu Thr Val Leu 
            20                  25                  30          
Pro Gly Val Glu Ala Ile Gly Leu Gly Tyr Asn Pro Phe Ile Ser Tyr 
        35                  40                  45              
Ala Ser Val Asn Ser Gly Ala Val Gln Leu Phe Asp Trp Ala Thr Ala 
    50                  55                  60                  
Lys Lys Arg Glu Val Pro Phe Lys Ala Gly Tyr Phe Val Pro Glu Leu 
65                  70                  75                  80  
Val Asp Val Gln Gln Asn Asp Ser Ala Thr Tyr Thr Asn Val Ser Gly 
                85                  90                  95      
Asn Thr Ile Ser Glu Tyr Gln Arg Ser Leu Ala Thr Ser Val Ala Ile 
            100                 105                 110         
Glu Gly Arg Tyr Asn Phe Phe Ser Gly Ser Leu Ser Thr Asp Phe Asp 
        115                 120                 125             
Ser Asn Ser Leu Arg Asn Ala Glu Asn Glu Phe Thr Arg Ile Gln Gln 
    130                 135                 140                 
Ser Ile Asn Leu Trp Ser Leu Arg Leu Pro Ser Val Lys Ser Leu Arg 
145                 150                 155                 160 
Glu Leu Met Leu Pro His Met Arg Gln Gln Leu Asp Glu Leu Asn Val 
                165                 170                 175     
Asn Asp Pro Lys Ala Ile Ser Arg Tyr Phe Asp Arg Val Gly Ser His 
            180                 185                 190         
Phe Leu Thr Gly Ile Val Met Gly Gly Arg Ala Ile Leu Ala Ser Ser 
        195                 200                 205             
Thr Asn Lys Leu Arg Val Lys Arg Asp Tyr Ser Val Ser Val Val Ala 
    210                 215                 220                 
Lys Ala Ser Tyr Glu Gly Leu Thr Gly Gln Leu Ser Ala Glu Ala Lys 
225                 230                 235                 240 
Ala Lys Tyr Gly Glu Ser Ile Ser Ser Phe Thr Gln Tyr Ser Asn Thr 
                245                 250                 255     
His Gln Glu Val Arg Gly Gly Asp Gly Ala Lys Ala His Gly Val Phe 
            260                 265                 270         
Ser Gly Lys Lys Glu Asp Phe Gln Ala Trp Val Asp Ser Val Ser Ala 
        275                 280                 285             
Ser Pro Asp Phe Val Asp Phe Val Pro Thr Ile Pro Met Gln Glu Ile 
    290                 295                 300                 
Trp Thr Leu Cys Ser Ser Glu Ala Gln Ala Glu Ala Met Arg Lys His 
305                 310                 315                 320 
Phe Asp Asp Val Trp Ala Pro Ala Gln Ser Glu Lys Phe Arg Val Lys 
                325                 330                 335     
Ala Asn Tyr Ile Asp Gln Leu Val Val Ile Thr Gly Gly Ser Ser Thr 
            340                 345                 350         
Ile Glu Pro Pro Val Gly Tyr Ser Lys Ile Glu Tyr Asp Leu Asn Ala 
        355                 360                 365             
Gly Ala Gly Gly Asp Phe Ile Tyr Leu Cys Tyr His Glu Gln Thr Trp 
    370                 375                 380                 
Gln Ala Asp Arg Pro Lys Asp Ala Val Thr Asp Ile Arg Ile Ile Phe 
385                 390                 395                 400 
Asn Lys Glu Pro Thr Pro Pro Gly Tyr Thr Lys Leu Pro Gln Asp Leu 
                405                 410                 415     
Asn Lys Gly Ala Gly Gly Asp Asp Val Phe Leu Cys Tyr Lys Thr Glu 
            420                 425                 430         
Ala Tyr Asn Thr Asp Thr Ala Ile Asn Lys Val Thr Val Ile Gly Gly 
        435                 440                 445             
Asn Asn Ala Asp Leu Asn Ala Pro Tyr Gly Tyr Leu Lys Val Pro Gly 
    450                 455                 460                 
Asp Leu Asn Arg Gly Ala Gly Gly Asn Phe Ile Tyr Ala Cys Thr Phe 
465                 470                 475                 480 
Val Gly Lys 
            

<210>  342
<211>  483
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  342
Met Glu Asn Ile Asp Leu Pro Gln Gly Leu Val Asn Phe Ser Thr Gln 
1               5                   10                  15      
His Leu Gln Leu Ile Arg Phe Lys Ala Gly Leu Asn Glu Thr Val Leu 
            20                  25                  30          
Pro Gly Val Glu Ala Ile Gly Leu Gly Tyr Asn Pro Phe Ile Ser Tyr 
        35                  40                  45              
Ala Ser Val Asn Ser Gly Ala Val Gln Leu Phe Asp Trp Ala Thr Ala 
    50                  55                  60                  
Lys Lys Arg Glu Val Pro Phe Lys Ala Gly Tyr Phe Val Pro Glu Leu 
65                  70                  75                  80  
Val Asp Val Gln Gln Asn Asp Ser Ala Thr Phe Thr Asn Val Ser Gly 
                85                  90                  95      
Asn Thr Ile Ser Glu Tyr Gln Arg Ser Leu Ala Thr Ser Val Ala Ile 
            100                 105                 110         
Glu Gly Arg Tyr Asn Phe Phe Ser Gly Ser Leu Ser Thr Asp Phe Asp 
        115                 120                 125             
Ser Asn Ser Leu Arg Asn Ala Glu Asn Glu Phe Thr Arg Ile Gln Gln 
    130                 135                 140                 
Ser Ile Asn Leu Trp Ser Leu Arg Leu Pro Ser Val Lys Ser Leu Arg 
145                 150                 155                 160 
Glu Leu Met Leu Pro His Met Arg Gln Gln Leu Asp Glu Leu Asn Val 
                165                 170                 175     
Asn Asp Pro Lys Ala Ile Ser Arg Tyr Phe Asp Arg Val Gly Ser His 
            180                 185                 190         
Phe Leu Thr Gly Ile Val Met Gly Gly Arg Ala Ile Leu Ala Ser Ser 
        195                 200                 205             
Thr Asn Lys Leu Arg Val Lys Arg Asp Tyr Ser Val Ser Val Val Ala 
    210                 215                 220                 
Lys Ala Ser Tyr Glu Gly Leu Thr Gly Gln Leu Ser Ala Glu Ala Lys 
225                 230                 235                 240 
Ala Lys Tyr Gly Glu Ser Ile Ser Ser Phe Thr Gln Tyr Ser Asn Thr 
                245                 250                 255     
His Gln Glu Val Arg Gly Gly Asp Gly Ala Lys Ala His Gly Val Phe 
            260                 265                 270         
Ser Gly Lys Lys Glu Asp Phe Gln Ala Trp Val Asp Ser Val Ser Ala 
        275                 280                 285             
Ser Pro Asp Phe Val Asp Phe Val Pro Thr Ile Pro Met Gln Glu Ile 
    290                 295                 300                 
Trp Thr Leu Cys Ser Ser Glu Ala Gln Ala Glu Ala Met Arg Lys His 
305                 310                 315                 320 
Tyr Asp Asp Val Trp Ala Pro Ala Gln Ser Glu Lys Phe Arg Val Lys 
                325                 330                 335     
Ala Asn Tyr Ile Asp Gln Leu Val Val Ile Thr Gly Gly Ser Ser Thr 
            340                 345                 350         
Leu Glu Pro Pro Val Gly Tyr Ser Lys Ile Glu Tyr Asp Leu Asn Ala 
        355                 360                 365             
Gly Ala Gly Gly Asp Phe Ile Tyr Leu Cys Tyr His Glu Gln Thr Trp 
    370                 375                 380                 
Gln Ala Asp Arg Pro Lys Asp Ala Val Thr Asp Ile Arg Ile Ile Phe 
385                 390                 395                 400 
Asn Lys Glu Pro Thr Pro Pro Gly Tyr Thr Lys Leu Pro Gln Asp Leu 
                405                 410                 415     
Asn Lys Gly Ala Gly Gly Asp Asp Val Phe Leu Cys Tyr Lys Thr Glu 
            420                 425                 430         
Ala Tyr Asn Thr Asp Thr Ala Ile Asn Lys Val Thr Val Ile Gly Gly 
        435                 440                 445             
Asn Asn Ala Asp Ile Asn Ala Pro Tyr Gly Tyr Leu Lys Val Pro Gly 
    450                 455                 460                 
Asp Leu Asn Arg Gly Ala Gly Gly Asn Phe Ile Tyr Ala Cys Thr Phe 
465                 470                 475                 480 
Val Gly Lys 
            

<210>  343
<211>  483
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  343
Met Glu Asn Ile Asp Leu Pro Gln Gly Leu Val Asn Phe Ser Thr Gln 
1               5                   10                  15      
His Leu Gln Leu Ile Arg Phe Lys Ala Gly Leu Asn Glu Thr Val Leu 
            20                  25                  30          
Pro Gly Val Glu Ala Ile Gly Leu Gly Tyr Asn Pro Phe Ile Ser Tyr 
        35                  40                  45              
Ala Ser Val Asn Ser Gly Ala Val Gln Leu Phe Asp Trp Ala Thr Ala 
    50                  55                  60                  
Lys Lys Arg Glu Val Pro Phe Lys Ala Gly Tyr Phe Val Pro Glu Leu 
65                  70                  75                  80  
Val Asp Val Gln Gln Asn Asp Ser Ala Thr Tyr Thr Asn Val Ser Gly 
                85                  90                  95      
Asn Thr Leu Ser Glu Tyr Gln Arg Ser Leu Ala Thr Ser Val Ala Ile 
            100                 105                 110         
Glu Gly Arg Tyr Asn Phe Phe Ser Gly Ser Leu Ser Thr Asp Phe Asp 
        115                 120                 125             
Ser Asn Ser Leu Arg Asn Ala Glu Asn Glu Phe Thr Arg Ile Gln Gln 
    130                 135                 140                 
Ser Ile Asn Leu Trp Ser Leu Arg Leu Pro Ser Val Lys Ser Leu Arg 
145                 150                 155                 160 
Glu Leu Met Leu Pro His Met Arg Gln Gln Leu Asp Glu Leu Asn Val 
                165                 170                 175     
Asn Asp Pro Lys Ala Ile Ser Arg Tyr Phe Asp Arg Val Gly Ser His 
            180                 185                 190         
Phe Leu Thr Gly Ile Val Met Gly Gly Arg Ala Ile Leu Ala Ser Ser 
        195                 200                 205             
Thr Asn Lys Leu Arg Val Lys Arg Asp Tyr Ser Val Ser Val Val Ala 
    210                 215                 220                 
Lys Ala Ser Tyr Glu Gly Leu Thr Gly Gln Leu Ser Ala Glu Ala Lys 
225                 230                 235                 240 
Ala Lys Tyr Gly Glu Ser Ile Ser Ser Phe Thr Gln Tyr Ser Asn Thr 
                245                 250                 255     
His Gln Glu Val Arg Gly Gly Asp Gly Ala Lys Ala His Gly Val Phe 
            260                 265                 270         
Ser Gly Lys Lys Glu Asp Phe Gln Ala Trp Val Asp Ser Val Ser Ala 
        275                 280                 285             
Ser Pro Asp Phe Val Asp Phe Val Pro Thr Ile Pro Met Gln Glu Ile 
    290                 295                 300                 
Trp Thr Leu Cys Ser Ser Glu Ala Gln Ala Glu Ala Met Arg Lys His 
305                 310                 315                 320 
Tyr Asp Asp Val Trp Ala Pro Ala Gln Ser Glu Lys Phe Arg Val Lys 
                325                 330                 335     
Ala Asn Tyr Ile Asp Gln Leu Val Val Ile Thr Gly Gly Ser Ser Thr 
            340                 345                 350         
Leu Glu Pro Pro Val Gly Tyr Ser Lys Ile Glu Tyr Asp Leu Asn Ala 
        355                 360                 365             
Gly Ala Gly Gly Asp Phe Ile Tyr Leu Cys Tyr His Glu Gln Thr Trp 
    370                 375                 380                 
Gln Ala Asp Arg Pro Lys Asp Ala Val Thr Asp Ile Arg Ile Ile Phe 
385                 390                 395                 400 
Asn Lys Glu Pro Thr Pro Pro Gly Tyr Thr Lys Leu Pro Gln Asp Leu 
                405                 410                 415     
Asn Lys Gly Ala Gly Gly Asp Asp Val Phe Leu Cys Tyr Lys Thr Glu 
            420                 425                 430         
Ala Tyr Asn Thr Asp Thr Ala Leu Asn Lys Val Thr Val Ile Gly Gly 
        435                 440                 445             
Asn Asn Ala Asp Ile Asn Ala Pro Tyr Gly Tyr Leu Lys Val Pro Gly 
    450                 455                 460                 
Asp Leu Asn Arg Gly Ala Gly Gly Asn Phe Ile Tyr Ala Cys Thr Phe 
465                 470                 475                 480 
Val Gly Lys 
            

<210>  344
<211>  483
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  344
Met Glu Asn Ile Asp Leu Pro Gln Gly Leu Val Asn Phe Ser Thr Gln 
1               5                   10                  15      
His Leu Gln Leu Ile Arg Phe Lys Ala Gly Leu Asn Glu Thr Val Leu 
            20                  25                  30          
Pro Gly Val Glu Ala Ile Gly Leu Gly Tyr Asn Pro Phe Ile Ser Tyr 
        35                  40                  45              
Ala Ser Val Asn Ser Gly Ala Val Gln Leu Phe Asp Trp Ala Thr Ala 
    50                  55                  60                  
Lys Lys Arg Glu Val Pro Phe Lys Ala Gly Tyr Phe Val Pro Glu Leu 
65                  70                  75                  80  
Val Asp Val Gln Gln Asn Asp Ser Ala Thr Phe Thr Asn Val Ser Gly 
                85                  90                  95      
Asn Thr Ile Ser Glu Tyr Gln Arg Ser Leu Ala Thr Ser Val Ala Ile 
            100                 105                 110         
Glu Gly Arg Tyr Asn Phe Phe Ser Gly Ser Leu Ser Thr Asp Phe Asp 
        115                 120                 125             
Ser Asn Ser Leu Arg Asn Ala Glu Asn Glu Phe Thr Arg Ile Gln Gln 
    130                 135                 140                 
Ser Ile Asn Leu Trp Ser Leu Arg Leu Pro Ser Val Lys Ser Leu Arg 
145                 150                 155                 160 
Glu Leu Met Leu Pro His Met Arg Gln Gln Leu Asp Glu Leu Asn Val 
                165                 170                 175     
Asn Asp Pro Lys Ala Ile Ser Arg Tyr Phe Asp Arg Val Gly Ser His 
            180                 185                 190         
Phe Leu Thr Gly Ile Val Met Gly Gly Arg Ala Ile Leu Ala Ser Ser 
        195                 200                 205             
Thr Asn Lys Leu Arg Val Lys Arg Asp Tyr Ser Val Ser Val Val Ala 
    210                 215                 220                 
Lys Ala Ser Tyr Glu Gly Leu Thr Gly Gln Leu Ser Ala Glu Ala Lys 
225                 230                 235                 240 
Ala Lys Tyr Gly Glu Ser Ile Ser Ser Phe Thr Gln Tyr Ser Asn Thr 
                245                 250                 255     
His Gln Glu Val Arg Gly Gly Asp Gly Ala Lys Ala His Gly Val Phe 
            260                 265                 270         
Ser Gly Lys Lys Glu Asp Phe Gln Ala Trp Val Asp Ser Val Ser Ala 
        275                 280                 285             
Ser Pro Asp Phe Val Asp Phe Val Pro Thr Ile Pro Met Gln Glu Ile 
    290                 295                 300                 
Trp Thr Leu Cys Ser Ser Glu Ala Gln Ala Glu Ala Met Arg Lys His 
305                 310                 315                 320 
Tyr Asp Asp Val Trp Ala Pro Ala Gln Ser Glu Lys Phe Arg Val Lys 
                325                 330                 335     
Ala Asn Tyr Ile Asp Gln Leu Val Val Ile Thr Gly Gly Ser Ser Thr 
            340                 345                 350         
Ile Glu Pro Pro Val Gly Tyr Ser Lys Ile Glu Tyr Asp Leu Asn Ala 
        355                 360                 365             
Gly Ala Gly Gly Asp Phe Ile Tyr Leu Cys Tyr His Glu Gln Thr Trp 
    370                 375                 380                 
Gln Ala Asp Arg Pro Lys Asp Ala Val Thr Asp Ile Arg Ile Ile Phe 
385                 390                 395                 400 
Asn Lys Glu Pro Thr Pro Pro Gly Tyr Thr Lys Leu Pro Gln Asp Leu 
                405                 410                 415     
Asn Lys Gly Ala Gly Gly Asp Asp Val Phe Leu Cys Tyr Lys Thr Glu 
            420                 425                 430         
Ala Tyr Asn Thr Asp Thr Ala Ile Asn Lys Val Thr Val Leu Gly Gly 
        435                 440                 445             
Asn Asn Ala Asp Ile Asn Ala Pro Tyr Gly Tyr Leu Lys Val Pro Gly 
    450                 455                 460                 
Asp Leu Asn Arg Gly Ala Gly Gly Asn Phe Ile Tyr Ala Cys Thr Phe 
465                 470                 475                 480 
Val Gly Lys 
            

<210>  345
<211>  1449
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  345
atggaacacg tagacctgcc aacgggtctg gtaaaatttt cctctaatca ccacctgcaa       60
ctgctgcgtg atacggcaga tctgagcgaa tccgtactgc ctggcgtcga agccattggt      120
ctgggctata acccattcct gggttatgcc ggtgtcggca gcggcacggt gcaactgttc      180
gactggaaca acgccaagaa aaaaaaagtg tctttcaaac ctgaattcgt cgtacctgag      240
atcgtcgacg tgcaacagaa cgacagcgca tcctacacca acatcagcgg caacacggtc      300
accgagtacc agcgcagcct ggctgtcagc gtcgccatcg aaggcaaata caacttcttc      360
agcggctctc tgtccacgga ttacgacgaa aattctctgc gcaacgcgga aaacgagttc      420
actcgcattc agcaatctat caacctgtgg tctctgcgcc tgccttctgt gaagtctctg      480
cgcgacctga tgctgccaca catgcgcgaa caactggatg aactggacgt caaaaacccg      540
agcgccatca gccgcttttt cgatcgtgtt ggcagccatt tcctgaccgg catcgtaatg      600
ggtggtcgtg ccatcctggc cgcctctacc aacaagctga aggtcaagcg tgactactct      660
gtgtctgtga tcgccaaggc gagctacgaa ggtctgaccg gccagctgag cgcagaagcc      720
cgtaccaagt atggcgagtc tatgagcagc ttcactcagt actccagcac ccaccaggaa      780
gtgcgcggcg gcgacggtac caaggcacat ggtgtgttcg aaggcaaagc aggtttccag      840
gcctgggtag acagcgtggg cacctctccg gacttcgtcg atttcgtccc taccatccct      900
atgctggaaa tctggtccct gtgcaaaacc gactctcagg ccgaggccat gaaacgtcat      960
ttcgataccg tctgggcgcg tgagcaatct gacaagtacc gtatcaaggc taactacatc     1020
gaccaactgg tggtcatcac cggcgatagc tctaccatcg aaccaccggc cggctacacc     1080
aagatcccgt acgacctgaa tgccggtgcc aaaggtgact tcatctacct gtgctatcac     1140
gaacaagcct ggtaccctga caacactaaa cctgctgtga cggctatcaa gatcatttac     1200
gaccgtgagc ctgtcccaac tggctatatc aagctgcctc aggacctgaa caagggcgcg     1260
ggcggtgctg atatctacct gtgctacaag ctggagggtt acaacaccga caccgcaatc     1320
aacaagatca cggtcatcag cggcaacaat ccggatatca acgctcctta tggttatgag     1380
aaggtccctg gtgacctgaa caaaggtgct aaaggcaact tcatctatgc ctgtaccttc     1440
gtaggcaag                                                             1449

<210>  346
<211>  1473
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  346
atggaaaaca tagacttgcc acaaggactt gtaaactttt ccacgcaaca cctgcaactt       60
attcgtttta aagcaggttt gaatgaaacc gtactacctg gcgtcgaagc cattggactt      120
ggctataacc cattcatcag ttatgccagt gtcaacagcg gcgcggtgca attgttcgac      180
tgggccacgg ccaagaaacg cgaagtgcct ttcaaagccg gctacttcgt acccgagatc      240
gtcgacgtgc aacagaacga cagcgcaacc tacaccaacg tcagcggcaa cacgatcagc      300
gagtaccagc gcagtctggc taccagcgtc gccatcgaag gccgttacaa cttcttcagt      360
ggctcgctgt ccacggattt cgacagtaat tcactgcgca acgcggaaaa cgagttcact      420
cgcattcagc aatcgatcaa cctctggtcg ttgcgcttgc cttcggtgaa gtcattgcgc      480
gaactgatgc tgccacacat gcgccaacaa ctagatgaat tgaacgtcaa cgacccgaag      540
gccataagcc gctatttcga tagagttggc agccatttcc ttaccggcat cgtaatgggt      600
ggacgggcca tcctcgcctc ctcgaccaac aagctcaggg tcaagcgtga ctactcggtg      660
tcggtggtcg ccaaggcgag ctacgaaggg cttaccggcc agttgagcgc agaagccaaa      720
gccaagtatg gcgagtcgat cagcagcttc actcagtact ccaataccca ccaggaagtg      780
cgcggcggcg acggtgccaa ggcacatggg gtgttcagcg gcaaaaaaga agatttccag      840
gcctgggtag acagtgtgag cgcctcgccg gacttcgtcg atttcgtccc caccatcccc      900
atgcaggaaa tctggaccct gtgcagcagc gaggcgcagg ccgaggccat gcgcaagcat      960
tacgatgacg tctgggcgcc ggcgcaatcg gaaaagtacc gggtcaaggc taactacatc     1020
gaccaactgg tggtcatcac cggcggtagt tcaaccatcg aaccaccggt cggctacagc     1080
aagatcgagt acgacctcaa tgccggtgcc ggcggtgact tcatctactt gtgctatcac     1140
gaacaaacct ggcaggccga caggcctaaa gatgctgtga cggatatcag gatcattttc     1200
aacaaggagc ctaccccacc tggctatacc aagctgcccc aggacctgaa caagggcgcg     1260
ggcggtgatg atgtattcct ctgctacaag accgaggctt acaacaccga caccgcaatc     1320
aacaaggtca cggtcatcgg cggcaacaat gcggatatca acgctcccta tggttatctg     1380
aaggtccccg gtgacctcaa cagaggtgct ggcggcaact tcatctatgc ctgtaccttc     1440
gtaggcaagc tcgagcacca ccaccaccac cac                                  1473

<210>  347
<211>  503
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  347
Met Gly Ser Ser His His His His His His Ser Ser Gly Leu Val Pro 
1               5                   10                  15      
Arg Gly Ser His Met Glu Asn Ile Asp Leu Pro Gln Gly Leu Val Asn 
            20                  25                  30          
Phe Ser Thr Gln His Leu Gln Leu Ile Arg Phe Lys Ala Gly Leu Asn 
        35                  40                  45              
Glu Thr Val Leu Pro Gly Val Glu Ala Ile Gly Leu Gly Tyr Asn Pro 
    50                  55                  60                  
Phe Ile Ser Tyr Ala Ser Val Asn Ser Gly Ala Val Gln Leu Phe Asp 
65                  70                  75                  80  
Trp Ala Thr Ala Lys Lys Arg Glu Val Pro Phe Lys Ala Gly Tyr Phe 
                85                  90                  95      
Val Pro Glu Ile Val Asp Val Gln Gln Asn Asp Ser Ala Thr Tyr Thr 
            100                 105                 110         
Asn Val Ser Gly Asn Thr Ile Ser Glu Tyr Gln Arg Ser Leu Ala Thr 
        115                 120                 125             
Ser Val Ala Ile Glu Gly Arg Tyr Asn Phe Phe Ser Gly Ser Leu Ser 
    130                 135                 140                 
Thr Asp Phe Asp Ser Asn Ser Leu Arg Asn Ala Glu Asn Glu Phe Thr 
145                 150                 155                 160 
Arg Ile Gln Gln Ser Ile Asn Leu Trp Ser Leu Arg Leu Pro Ser Val 
                165                 170                 175     
Lys Ser Leu Arg Glu Leu Met Leu Pro His Met Arg Gln Gln Leu Asp 
            180                 185                 190         
Glu Leu Asn Val Asn Asp Pro Lys Ala Ile Ser Arg Tyr Phe Asp Arg 
        195                 200                 205             
Val Gly Ser His Phe Leu Thr Gly Ile Val Met Gly Gly Arg Ala Ile 
    210                 215                 220                 
Leu Ala Ser Ser Thr Asn Lys Leu Arg Val Lys Arg Asp Tyr Ser Val 
225                 230                 235                 240 
Ser Val Val Ala Lys Ala Ser Tyr Glu Gly Leu Thr Gly Gln Leu Ser 
                245                 250                 255     
Ala Glu Ala Lys Ala Lys Tyr Gly Glu Ser Ile Ser Ser Phe Thr Gln 
            260                 265                 270         
Tyr Ser Asn Thr His Gln Glu Val Arg Gly Gly Asp Gly Ala Lys Ala 
        275                 280                 285             
His Gly Val Phe Ser Gly Lys Lys Glu Asp Phe Gln Ala Trp Val Asp 
    290                 295                 300                 
Ser Val Ser Ala Ser Pro Asp Phe Val Asp Phe Val Pro Thr Ile Pro 
305                 310                 315                 320 
Met Gln Glu Ile Trp Thr Leu Cys Ser Ser Glu Ala Gln Ala Glu Ala 
                325                 330                 335     
Met Arg Lys His Tyr Asp Asp Val Trp Ala Pro Ala Gln Ser Glu Lys 
            340                 345                 350         
Tyr Arg Val Lys Ala Asn Tyr Ile Asp Gln Leu Val Val Ile Thr Gly 
        355                 360                 365             
Gly Ser Ser Thr Ile Glu Pro Pro Val Gly Tyr Ser Lys Ile Glu Tyr 
    370                 375                 380                 
Asp Leu Asn Ala Gly Ala Gly Gly Asp Phe Ile Tyr Leu Cys Tyr His 
385                 390                 395                 400 
Glu Gln Thr Trp Gln Ala Asp Arg Pro Lys Asp Ala Val Thr Asp Ile 
                405                 410                 415     
Arg Ile Ile Phe Asn Lys Glu Pro Thr Pro Pro Gly Tyr Thr Lys Leu 
            420                 425                 430         
Pro Gln Asp Leu Asn Lys Gly Ala Gly Gly Asp Asp Val Phe Leu Cys 
        435                 440                 445             
Tyr Lys Thr Glu Ala Tyr Asn Thr Asp Thr Ala Ile Asn Lys Val Thr 
    450                 455                 460                 
Val Ile Gly Gly Asn Asn Ala Asp Ile Asn Ala Pro Tyr Gly Tyr Leu 
465                 470                 475                 480 
Lys Val Pro Gly Asp Leu Asn Arg Gly Ala Gly Gly Asn Phe Ile Tyr 
                485                 490                 495     
Ala Cys Thr Phe Val Gly Lys 
            500             

<210>  348
<211>  1473
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  348
atggaaaaca tagacttgcc acaaggactt gtaaactttt ccacgcaaca cctgcaactt       60
attcgtttta aagcaggttt gaatgaaacc gtactacctg gcgtcgaagc cattggactt      120
ggctataacc cattcatcag ttatgccagt gtcaacagcg gcgcggtgca attgttcgac      180
tgggccacgg ccaagaaacg cgaagtgcct ttcaaagccg gctacttcgt acccgagatc      240
gtcgacgtgc aacagaacga cagcgcaacc tacaccaacg tcagcggcaa cacgatcagc      300
gagtaccagc gcagtctggc taccagcgtc gccatcgaag gccgttacaa cttcttcagt      360
ggctcgctgt ccacggattt cgacagtaat tcactgcgca acgcggaaaa cgagttcact      420
cgcattcagc aatcgatcaa cctctggtcg ttgcgcttgc cttcggtgaa gtcattgcgc      480
gaactgatgc tgccacacat gcgccaacaa ctagatgaat tgaacgtcaa cgacccgaag      540
gccataagcc gctatttcga tagagttggc agccatttcc ttaccggcat cgtaatgggt      600
ggacgggcca tcctcgcctc ctcgaccaac aagctcaggg tcaagcgtga ctactcggtg      660
tcggtggtcg ccaaggcgag ctacgaaggg cttaccggcc agttgagcgc agaagccaaa      720
gccaagtatg gcgagtcgat cagcagcttc actcagtact ccaataccca ccaggaagtg      780
cgcggcggcg acggtgccaa ggcacatggg gtgttcagcg gcaaaaaaga agatttccag      840
gcctgggtag acagtgtgag cgcctcgccg gacttcgtcg atttcgtccc caccatcccc      900
atgcaggaaa tctggaccct gtgcagcagc gaggcgcagg ccgaggccat gcgcaagcat      960
tacgatgacg tctgggcgcc ggcgcaatcg gaaaagtacc gggtcaaggc taactacatc     1020
gaccaactgg tggtcatcac cggcggtagt tcaaccatcg aaccaccggt cggctacagc     1080
aagatcgagt acgacctcaa tgccggtgcc ggcggtgact tcatctactt gtgctatcac     1140
gaacaaacct ggcaggccga caggcctaaa gatgctgtga cggatatcag gatcattttc     1200
aacaaggagc ctaccccacc tggctatacc aagctgcccc aggacctgaa caagggcgcg     1260
ggcggtgatg atgtattcct ctgctacaag accgaggctt acaacaccga caccgcaatc     1320
aacaaggtca cggtcatcgg cggcaacaat gcggatatca acgctcccta tggttatctg     1380
aaggtccccg gtgacctcaa cagaggtgct ggcggcaact tcatctatgc ctgtaccttc     1440
gtaggcaagc tcgagcacca ccaccaccac cac                                  1473

<210>  349
<211>  491
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  349
Met Glu Asn Ile Asp Leu Pro Gln Gly Leu Val Asn Phe Ser Thr Gln 
1               5                   10                  15      
His Leu Gln Leu Ile Arg Phe Lys Ala Gly Leu Asn Glu Thr Val Leu 
            20                  25                  30          
Pro Gly Val Glu Ala Ile Gly Leu Gly Tyr Asn Pro Phe Ile Ser Tyr 
        35                  40                  45              
Ala Ser Val Asn Ser Gly Ala Val Gln Leu Phe Asp Trp Ala Thr Ala 
    50                  55                  60                  
Lys Lys Arg Glu Val Pro Phe Lys Ala Gly Tyr Phe Val Pro Glu Ile 
65                  70                  75                  80  
Val Asp Val Gln Gln Asn Asp Ser Ala Thr Tyr Thr Asn Val Ser Gly 
                85                  90                  95      
Asn Thr Ile Ser Glu Tyr Gln Arg Ser Leu Ala Thr Ser Val Ala Ile 
            100                 105                 110         
Glu Gly Arg Tyr Asn Phe Phe Ser Gly Ser Leu Ser Thr Asp Phe Asp 
        115                 120                 125             
Ser Asn Ser Leu Arg Asn Ala Glu Asn Glu Phe Thr Arg Ile Gln Gln 
    130                 135                 140                 
Ser Ile Asn Leu Trp Ser Leu Arg Leu Pro Ser Val Lys Ser Leu Arg 
145                 150                 155                 160 
Glu Leu Met Leu Pro His Met Arg Gln Gln Leu Asp Glu Leu Asn Val 
                165                 170                 175     
Asn Asp Pro Lys Ala Ile Ser Arg Tyr Phe Asp Arg Val Gly Ser His 
            180                 185                 190         
Phe Leu Thr Gly Ile Val Met Gly Gly Arg Ala Ile Leu Ala Ser Ser 
        195                 200                 205             
Thr Asn Lys Leu Arg Val Lys Arg Asp Tyr Ser Val Ser Val Val Ala 
    210                 215                 220                 
Lys Ala Ser Tyr Glu Gly Leu Thr Gly Gln Leu Ser Ala Glu Ala Lys 
225                 230                 235                 240 
Ala Lys Tyr Gly Glu Ser Ile Ser Ser Phe Thr Gln Tyr Ser Asn Thr 
                245                 250                 255     
His Gln Glu Val Arg Gly Gly Asp Gly Ala Lys Ala His Gly Val Phe 
            260                 265                 270         
Ser Gly Lys Lys Glu Asp Phe Gln Ala Trp Val Asp Ser Val Ser Ala 
        275                 280                 285             
Ser Pro Asp Phe Val Asp Phe Val Pro Thr Ile Pro Met Gln Glu Ile 
    290                 295                 300                 
Trp Thr Leu Cys Ser Ser Glu Ala Gln Ala Glu Ala Met Arg Lys His 
305                 310                 315                 320 
Tyr Asp Asp Val Trp Ala Pro Ala Gln Ser Glu Lys Tyr Arg Val Lys 
                325                 330                 335     
Ala Asn Tyr Ile Asp Gln Leu Val Val Ile Thr Gly Gly Ser Ser Thr 
            340                 345                 350         
Ile Glu Pro Pro Val Gly Tyr Ser Lys Ile Glu Tyr Asp Leu Asn Ala 
        355                 360                 365             
Gly Ala Gly Gly Asp Phe Ile Tyr Leu Cys Tyr His Glu Gln Thr Trp 
    370                 375                 380                 
Gln Ala Asp Arg Pro Lys Asp Ala Val Thr Asp Ile Arg Ile Ile Phe 
385                 390                 395                 400 
Asn Lys Glu Pro Thr Pro Pro Gly Tyr Thr Lys Leu Pro Gln Asp Leu 
                405                 410                 415     
Asn Lys Gly Ala Gly Gly Asp Asp Val Phe Leu Cys Tyr Lys Thr Glu 
            420                 425                 430         
Ala Tyr Asn Thr Asp Thr Ala Ile Asn Lys Val Thr Val Ile Gly Gly 
        435                 440                 445             
Asn Asn Ala Asp Ile Asn Ala Pro Tyr Gly Tyr Leu Lys Val Pro Gly 
    450                 455                 460                 
Asp Leu Asn Arg Gly Ala Gly Gly Asn Phe Ile Tyr Ala Cys Thr Phe 
465                 470                 475                 480 
Val Gly Lys Leu Glu His His His His His His 
                485                 490     

<210>  350
<211>  1500
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  350
atgaaaagcc tggaccatgt ggcacaccag aacctgctga atgaaccgac ccatcataag       60
agcaacacca aagcggcgct gatgcgccac caggaaaacc tggtggaacg ctatctgcct      120
ggtgttgaag tgatcggcgc cggttacaac ccgttcggtg tctacgctag cacggattcc      180
gtaactgtac agctgttcga ctggcagtct gcgccgtctg aaccggttat cttcaacccg      240
gactacatcg caccaaaagc ggtgtctgtg cagcagaacg acgaagcccg ttacactaac      300
gtctccggta agactatcaa cacgtttcag aaaaacttca gcctgaaagt gacggtggct      360
ggttcttaca acctgttcag cggttctgtg agcaacgaat tcagctcttc tgaaactcgt      420
aacgctgaga acgaattctc ccgtatccag cagagcatcc gtgtttggtc cctgcgtctg      480
gcgtatactg acagcctgcg cgaatacctg aaagcggacg tacgtgacta catcgacagc      540
attcaatccg atgcgcagat cgaaatcctg ttcgatcgtt acggctctca tttcctgacc      600
ggtgtagtta tgggcggtgc agctatcatg gcgagctcca ccaacaaagt gcaggtggac      660
cacacttatg aaaacgaaac catcgccaaa gcgtcttacg aagctctgac cggtcagatc      720
agcgctgaaa ccgctgcgaa ataccgtcag tctatgagct ctttctctca aaactccgac      780
atccacaaga tcgttgttgg tggcgatggt gttgctggtg ctaaagtgta ctctggtgat      840
aaagctgatt ttgatgcgtg ggccgatacc gtcggtacca gcccggattt tgtagatttt      900
gtttcctccg tgccgatgct gggtatctgg gagctgtgta aagatgatgc ccaggcaaag      960
aaaatggagg actattacaa caacacctgg gcgccacgca agagcaaaga agcgcaaatc     1020
tacgcggact acatcgatgc agtcgaagtg atccagtcca attccagcgg tgttcgccca     1080
ccgagcggct acacgaaaat cgattacgat ctgaacaaag gtgcaggcgg cgactacatc     1140
tacctgtgct accataaagc tcgctactct gcttactctg aaaacaaaga ttgcgtttct     1200
gacctgatca tcatcaaagg taacggtgcg cgcgctccaa gcggttacac taaaattgat     1260
gtggacctga acgaagatgc cggcggcaag tatctgtatc tgtgttataa aaaacagtct     1320
tacgataacg ttgaagcgat taaaggcctg gctgtggtag gcggcgacaa ctctcacact     1380
ccggctccgt acggctaccg ccgtattgac accgatgtaa acgagggtgc tggtggcgaa     1440
tatatttata tttgctattc caaaggcgcc ggatccctcg agcaccacca ccaccaccac     1500

<210>  351
<211>  500
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  351
Met Lys Ser Leu Asp His Val Ala His Gln Asn Leu Leu Asn Glu Pro 
1               5                   10                  15      
Thr His His Lys Ser Asn Thr Lys Ala Ala Leu Met Arg His Gln Glu 
            20                  25                  30          
Asn Leu Val Glu Arg Tyr Leu Pro Gly Val Glu Val Ile Gly Ala Gly 
        35                  40                  45              
Tyr Asn Pro Phe Gly Val Tyr Ala Ser Thr Asp Ser Val Thr Val Gln 
    50                  55                  60                  
Leu Phe Asp Trp Gln Ser Ala Pro Ser Glu Pro Val Ile Phe Asn Pro 
65                  70                  75                  80  
Asp Tyr Ile Ala Pro Lys Ala Val Ser Val Gln Gln Asn Asp Glu Ala 
                85                  90                  95      
Arg Tyr Thr Asn Val Ser Gly Lys Thr Ile Asn Thr Phe Gln Lys Asn 
            100                 105                 110         
Phe Ser Leu Lys Val Thr Val Ala Gly Ser Tyr Asn Leu Phe Ser Gly 
        115                 120                 125             
Ser Val Ser Asn Glu Phe Ser Ser Ser Glu Thr Arg Asn Ala Glu Asn 
    130                 135                 140                 
Glu Phe Ser Arg Ile Gln Gln Ser Ile Arg Val Trp Ser Leu Arg Leu 
145                 150                 155                 160 
Ala Tyr Thr Asp Ser Leu Arg Glu Tyr Leu Lys Ala Asp Val Arg Asp 
                165                 170                 175     
Tyr Ile Asp Ser Ile Gln Ser Asp Ala Gln Ile Glu Ile Leu Phe Asp 
            180                 185                 190         
Arg Tyr Gly Ser His Phe Leu Thr Gly Val Val Met Gly Gly Ala Ala 
        195                 200                 205             
Ile Met Ala Ser Ser Thr Asn Lys Val Gln Val Asp His Thr Tyr Glu 
    210                 215                 220                 
Asn Glu Thr Ile Ala Lys Ala Ser Tyr Glu Ala Leu Thr Gly Gln Ile 
225                 230                 235                 240 
Ser Ala Glu Thr Ala Ala Lys Tyr Arg Gln Ser Met Ser Ser Phe Ser 
                245                 250                 255     
Gln Asn Ser Asp Ile His Lys Ile Val Val Gly Gly Asp Gly Val Ala 
            260                 265                 270         
Gly Ala Lys Val Tyr Ser Gly Asp Lys Ala Asp Phe Asp Ala Trp Ala 
        275                 280                 285             
Asp Thr Val Gly Thr Ser Pro Asp Phe Val Asp Phe Val Ser Ser Val 
    290                 295                 300                 
Pro Met Leu Gly Ile Trp Glu Leu Cys Lys Asp Asp Ala Gln Ala Lys 
305                 310                 315                 320 
Lys Met Glu Asp Tyr Tyr Asn Asn Thr Trp Ala Pro Arg Lys Ser Lys 
                325                 330                 335     
Glu Ala Gln Ile Tyr Ala Asp Tyr Ile Asp Ala Val Glu Val Ile Gln 
            340                 345                 350         
Ser Asn Ser Ser Gly Val Arg Pro Pro Ser Gly Tyr Thr Lys Ile Asp 
        355                 360                 365             
Tyr Asp Leu Asn Lys Gly Ala Gly Gly Asp Tyr Ile Tyr Leu Cys Tyr 
    370                 375                 380                 
His Lys Ala Arg Tyr Ser Ala Tyr Ser Glu Asn Lys Asp Cys Val Ser 
385                 390                 395                 400 
Asp Leu Ile Ile Ile Lys Gly Asn Gly Ala Arg Ala Pro Ser Gly Tyr 
                405                 410                 415     
Thr Lys Ile Asp Val Asp Leu Asn Glu Asp Ala Gly Gly Lys Tyr Leu 
            420                 425                 430         
Tyr Leu Cys Tyr Lys Lys Gln Ser Tyr Asp Asn Val Glu Ala Ile Lys 
        435                 440                 445             
Gly Leu Ala Val Val Gly Gly Asp Asn Ser His Thr Pro Ala Pro Tyr 
    450                 455                 460                 
Gly Tyr Arg Arg Ile Asp Thr Asp Val Asn Glu Gly Ala Gly Gly Glu 
465                 470                 475                 480 
Tyr Ile Tyr Ile Cys Tyr Ser Lys Gly Ala Gly Ser Leu Glu His His 
                485                 490                 495     
His His His His 
            500 

<210>  352
<211>  1509
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  352
atgggcagca gccatcatca tcatcatcac agcagcggcc tggtgccgcg cggcagccat       60
atggaacacg tcgacctgcc gacgggactc gtcaaatttt ccagcaatca ccatctgcaa      120
ttgctgcgcg acaccgccga cctcagtgaa tcagtgcttc cgggcgtaga ggccattggc      180
ttgggataca acccattcct cggctacgcc ggtgtgggaa gcggcaccgt ccagcttttc      240
gactggaaca acgcaaaaaa gaaaaaagtg tcattcaaac ccgagttcgt cgtgccggag      300
atcgtcgacg tccagcagaa tgacagcgcc agctacacca acatcagtgg caacaccgtc      360
accgagtatc aacgcagcct ggccgtcagc gtggccatcg aaggcaaata caacttcttc      420
agtggttcgc tttcaaccga ctacgacgaa aactcgctgc gtaatgccga gaacgagttc      480
acccgtatcc agcaatcgat caacctctgg tcgctgcgcc tgccttcggt caaatcactg      540
cgcgacctga tgctgccgca catgcgtgag caactggatg agctggacgt gaaaaacccg      600
agtgccatca gccggttctt cgaccgggtg ggcagccact tcctcaccgg catcgtgatg      660
ggcggccgag ccatactcgc cgcctcgacc aacaaactga aggtcaagcg cgactactcc      720
gtgtcggtca tcgccaaggc gagctacgaa ggcttgaccg gccagctgag cgccgaggcc      780
aggaccaagt acggcgaatc catgagcagt ttcacccagt actccagcac ccaccaggaa      840
gtccgtggcg gcgatggcac caaggcccat ggtgtgttcg agggcaaggc cgggttccag      900
gcctgggtcg acagcgtggg gacctcgccc gatttcgtcg acttcgtgcc caccatcccg      960
atgctggaga tctggagcct gtgcaagacc gattcacagg ctgaagccat gaagcgccat     1020
ttcgacacgg tctgggcccg cgaacaatcg gacaagtacc ggataaaggc gaactacatc     1080
gatcagctgg tggtaatcac cggtgacagt tcgaccatcg aacctccggc tggctatacc     1140
aagattccct acgacctcaa tgccggggcc aagggcgact tcatctattt gtgctaccac     1200
gaacaagcgt ggtatcccga caacaccaaa cctgccgtca ccgcgatcaa gatcatctac     1260
gaccgggaac cggtacccac cgggtatatc aagctgccgc aagacctcaa caaaggcgca     1320
ggtggcgcgg acatctacct ttgctacaag ctcgagggct acaacaccga taccgcgatc     1380
aacaagatca ccgtgatcag cgggaacaac cccgacatta acgcccccta tggctatgag     1440
aaagtgccgg gcgacctgaa caagggcgca aaaggcaact tcatctatgc ctgcactttc     1500
gtcggcaag                                                             1509

<210>  353
<211>  503
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  353
Met Gly Ser Ser His His His His His His Ser Ser Gly Leu Val Pro 
1               5                   10                  15      
Arg Gly Ser His Met Glu His Val Asp Leu Pro Thr Gly Leu Val Lys 
            20                  25                  30          
Phe Ser Ser Asn His His Leu Gln Leu Leu Arg Asp Thr Ala Asp Leu 
        35                  40                  45              
Ser Glu Ser Val Leu Pro Gly Val Glu Ala Ile Gly Leu Gly Tyr Asn 
    50                  55                  60                  
Pro Phe Leu Gly Tyr Ala Gly Val Gly Ser Gly Thr Val Gln Leu Phe 
65                  70                  75                  80  
Asp Trp Asn Asn Ala Lys Lys Lys Lys Val Ser Phe Lys Pro Glu Phe 
                85                  90                  95      
Val Val Pro Glu Ile Val Asp Val Gln Gln Asn Asp Ser Ala Ser Tyr 
            100                 105                 110         
Thr Asn Ile Ser Gly Asn Thr Val Thr Glu Tyr Gln Arg Ser Leu Ala 
        115                 120                 125             
Val Ser Val Ala Ile Glu Gly Lys Tyr Asn Phe Phe Ser Gly Ser Leu 
    130                 135                 140                 
Ser Thr Asp Tyr Asp Glu Asn Ser Leu Arg Asn Ala Glu Asn Glu Phe 
145                 150                 155                 160 
Thr Arg Ile Gln Gln Ser Ile Asn Leu Trp Ser Leu Arg Leu Pro Ser 
                165                 170                 175     
Val Lys Ser Leu Arg Asp Leu Met Leu Pro His Met Arg Glu Gln Leu 
            180                 185                 190         
Asp Glu Leu Asp Val Lys Asn Pro Ser Ala Ile Ser Arg Phe Phe Asp 
        195                 200                 205             
Arg Val Gly Ser His Phe Leu Thr Gly Ile Val Met Gly Gly Arg Ala 
    210                 215                 220                 
Ile Leu Ala Ala Ser Thr Asn Lys Leu Lys Val Lys Arg Asp Tyr Ser 
225                 230                 235                 240 
Val Ser Val Ile Ala Lys Ala Ser Tyr Glu Gly Leu Thr Gly Gln Leu 
                245                 250                 255     
Ser Ala Glu Ala Arg Thr Lys Tyr Gly Glu Ser Met Ser Ser Phe Thr 
            260                 265                 270         
Gln Tyr Ser Ser Thr His Gln Glu Val Arg Gly Gly Asp Gly Thr Lys 
        275                 280                 285             
Ala His Gly Val Phe Glu Gly Lys Ala Gly Phe Gln Ala Trp Val Asp 
    290                 295                 300                 
Ser Val Gly Thr Ser Pro Asp Phe Val Asp Phe Val Pro Thr Ile Pro 
305                 310                 315                 320 
Met Leu Glu Ile Trp Ser Leu Cys Lys Thr Asp Ser Gln Ala Glu Ala 
                325                 330                 335     
Met Lys Arg His Phe Asp Thr Val Trp Ala Arg Glu Gln Ser Asp Lys 
            340                 345                 350         
Tyr Arg Ile Lys Ala Asn Tyr Ile Asp Gln Leu Val Val Ile Thr Gly 
        355                 360                 365             
Asp Ser Ser Thr Ile Glu Pro Pro Ala Gly Tyr Thr Lys Ile Pro Tyr 
    370                 375                 380                 
Asp Leu Asn Ala Gly Ala Lys Gly Asp Phe Ile Tyr Leu Cys Tyr His 
385                 390                 395                 400 
Glu Gln Ala Trp Tyr Pro Asp Asn Thr Lys Pro Ala Val Thr Ala Ile 
                405                 410                 415     
Lys Ile Ile Tyr Asp Arg Glu Pro Val Pro Thr Gly Tyr Ile Lys Leu 
            420                 425                 430         
Pro Gln Asp Leu Asn Lys Gly Ala Gly Gly Ala Asp Ile Tyr Leu Cys 
        435                 440                 445             
Tyr Lys Leu Glu Gly Tyr Asn Thr Asp Thr Ala Ile Asn Lys Ile Thr 
    450                 455                 460                 
Val Ile Ser Gly Asn Asn Pro Asp Ile Asn Ala Pro Tyr Gly Tyr Glu 
465                 470                 475                 480 
Lys Val Pro Gly Asp Leu Asn Lys Gly Ala Lys Gly Asn Phe Ile Tyr 
                485                 490                 495     
Ala Cys Thr Phe Val Gly Lys 
            500             

<210>  354
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  gene isolation primer

<400>  354
cataaggaaa tccatatgga aaacatagac ttg                                    33

<210>  355
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  gene isolation primer

<400>  355
attgggcgca gctcgagcta cttgccta                                          28

<210>  356
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  gene isolation primer

<400>  356
gcgcagcagc tcgagcttgc ctacgaa                                           27

<210>  357
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  gene isolation primer

<400>  357
gcaacttatt cgtcatatgg caggtttgaa tgaaacc                                37

<210>  358
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  gene isolation primer

<400>  358
atagggacat ccatatggaa cacgtcga                                          28

<210>  359
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  gene isolation primer

<400>  359
aagccagggt ggatccttac ttgccg                                            26

<210>  360
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mutagenesis primer

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  m = a or c

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  r = a or g

<220>
<221>  misc_feature
<222>  (39)..(39)
<223>  r = a or g

<400>  360
gaaggagata tacatatgga amacrtagac ttgccacarg gacttgtaaa cttttcc          57

<210>  361
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mutagenesis primer

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  m = a or c

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  r = a or g

<220>
<221>  misc_feature
<222>  (39)..(39)
<223>  r = a or g

<400>  361
gaaggagata tacatatgga amacrtcgac ctgccgacrg gactcgtcaa attttcc          57

<210>  362
<211>  53
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mutagenesis primer

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  r = a or g

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  s = c or g

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  s = c or g

<220>
<221>  misc_feature
<222>  (26)..(26)
<223>  r = a or g

<220>
<221>  misc_feature
<222>  (32)..(32)
<223>  y = c or t

<220>
<221>  misc_feature
<222>  (41)..(41)
<223>  m = a or c

<220>
<221>  misc_feature
<222>  (43)..(43)
<223>  s = c or g

<400>  362
tcgtrccsga gatcgtcgac gtscarcaga aygacagcgc masctacacc aac              53

<210>  363
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mutagenesis primer

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  s = c or g

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  k = g or t

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  r = a or g

<220>
<221>  misc_feature
<222>  (28)..(28)
<223>  y = c or t

<220>
<221>  misc_feature
<222>  (31)..(31)
<223>  s = c or g

<400>  363
gttggtgtag stkgcgctgt crttctgytg sacgtcgacg atctc                       45

<210>  364
<211>  43
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mutagenesis primer

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  y = c or t

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  y = c or t

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  y = c or t

<400>  364
aacgagttcc acycgyatyc agcaatcgat caacctctgg tcg                         43

<210>  365
<211>  41
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mutagenesis primer

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  r = a or g

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  r = a or g

<400>  365
accgaaggca rgcgcarcga ccagaggttg atcgattgct g                           41

<210>  366
<211>  49
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mutagenesis primer

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  r = a or g

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  y = c or t

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  m = a or c

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  r = a or g

<220>
<221>  misc_feature
<222>  (30)..(30)
<223>  m = a or c

<220>
<221>  misc_feature
<222>  (37)..(37)
<223>  k = g or t

<400>  366
accggcatcg tratgggygg mcgrgccatm ctcgcckcct cggaccaac                   49

<210>  367
<211>  49
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mutagenesis primer

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  m = a or c

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  k = g or t

<220>
<221>  misc_feature
<222>  (26)..(26)
<223>  y = c or t

<220>
<221>  misc_feature
<222>  (29)..(29)
<223>  k = g or t

<220>
<221>  misc_feature
<222>  (32)..(32)
<223>  r = a or g

<220>
<221>  misc_feature
<222>  (38)..(38)
<223>  y = c or t

<400>  367
gttggtccga ggmggcgagk atggcycgkc crcccatyac gatgccggt                   49

<210>  368
<211>  65
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mutagenesis primer

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  m = a or c

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  y = c or t

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  r = a or g

<220>
<221>  misc_feature
<222>  (28)..(28)
<223>  r = a or g

<220>
<221>  misc_feature
<222>  (36)..(36)
<223>  s = c or g

<220>
<221>  misc_feature
<222>  (39)..(39)
<223>  y = c or t

<220>
<221>  misc_feature
<222>  (48)..(48)
<223>  y = c or t

<220>
<221>  misc_feature
<222>  (54)..(54)
<223>  y = c or t

<400>  368
ttccaggcct gggtmgacag ygtgrgcrcc tcgccsgayt tcgtcgaytt cgtycccacc       60
atccc                                                                   65

<210>  369
<211>  65
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mutagenesis primer

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  r = a or g

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  r = a or g

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  r = a or g

<220>
<221>  misc_feature
<222>  (30)..(30)
<223>  s = c or g

<220>
<221>  misc_feature
<222>  (38)..(38)
<223>  y = c or t

<220>
<221>  misc_feature
<222>  (41)..(41)
<223>  y = c or t

<220>
<221>  misc_feature
<222>  (45)..(45)
<223>  r = a or g

<220>
<221>  misc_feature
<222>  (51)..(51)
<223>  k = g or t

<400>  369
gggatggtgg gracgaartc gacgaartcs ggcgaggygc ycacrctgtc kacccaggcc       60
tggaa                                                                   65

<210>  370
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mutagenesis primer

<400>  370
tacgacctca atgccgg                                                      17

<210>  371
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mutagenesis primer

<400>  371
ccggcattga ggtcgta                                                      17

<210>  372
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mutagenesis primer

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  y = c or t

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  r = a or g

<400>  372
tacaacaccg ayaccgcrat caacaag                                           27

<210>  373
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mutagenesis primer

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  y = c or t

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  r = c or t

<400>  373
cttgttgaty gcggtrtcgg tgttgta                                           27

<210>  374
<211>  59
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mutagenesis primer

<400>  374
ctcagtggtg gtggtggtgg tgctcgagct acttgcctac gaaggtacag gcatagatg        59

<210>  375
<211>  59
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mutagenesis primer

<400>  375
ctcagtggtg gtggtggtgg tgctcgagtt acttgccgac gaaagtgcag gcatagatg        59

<210>  376
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide linker

<400>  376
Glu Glu Lys Lys Asn 
1               5   

<210>  377
<211>  484
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IPD090 variant

<400>  377
Met Ala Glu Asn Ile Asp Leu Pro Gln Gly Leu Val Asn Phe Ser Thr 
1               5                   10                  15      
Gln His Leu Gln Leu Ile Arg Phe Lys Ala Gly Leu Asn Glu Thr Val 
            20                  25                  30          
Leu Pro Gly Val Glu Ala Ile Gly Leu Gly Tyr Asn Pro Phe Ile Ser 
        35                  40                  45              
Tyr Ala Ser Val Asn Ser Gly Ala Val Gln Leu Phe Asp Trp Ala Thr 
    50                  55                  60                  
Ala Lys Lys Arg Glu Val Pro Phe Lys Ala Gly Tyr Phe Val Pro Glu 
65                  70                  75                  80  
Ile Val Asp Val Gln Gln Asn Asp Ser Ala Thr Tyr Thr Asn Val Ser 
                85                  90                  95      
Gly Asn Thr Ile Ser Glu Tyr Gln Arg Ser Leu Ala Thr Ser Val Ala 
            100                 105                 110         
Ile Glu Gly Arg Tyr Asn Phe Phe Ser Gly Ser Leu Ser Thr Asp Phe 
        115                 120                 125             
Asp Ser Asn Ser Leu Arg Asn Ala Glu Asn Glu Phe Thr Arg Ile Gln 
    130                 135                 140                 
Gln Ser Ile Asn Leu Trp Ser Leu Arg Leu Pro Ser Val Lys Ser Leu 
145                 150                 155                 160 
Arg Glu Leu Met Leu Pro His Met Arg Gln Gln Leu Asp Glu Leu Asn 
                165                 170                 175     
Val Asn Asp Pro Lys Ala Ile Ser Arg Tyr Phe Asp Arg Val Gly Ser 
            180                 185                 190         
His Phe Leu Thr Gly Ile Val Met Gly Gly Arg Ala Ile Leu Ala Ser 
        195                 200                 205             
Ser Thr Asn Lys Leu Arg Val Lys Arg Asp Tyr Ser Val Ser Val Val 
    210                 215                 220                 
Ala Lys Ala Ser Tyr Glu Gly Leu Thr Gly Gln Leu Ser Ala Glu Ala 
225                 230                 235                 240 
Lys Ala Lys Tyr Gly Glu Ser Ile Ser Ser Phe Thr Gln Tyr Ser Asn 
                245                 250                 255     
Thr His Gln Glu Val Arg Gly Gly Asp Gly Ala Lys Ala His Gly Val 
            260                 265                 270         
Phe Ser Gly Lys Lys Glu Asp Phe Gln Ala Trp Val Asp Ser Val Ser 
        275                 280                 285             
Ala Ser Pro Asp Phe Val Asp Phe Val Pro Thr Ile Pro Met Gln Glu 
    290                 295                 300                 
Ile Trp Thr Leu Cys Ser Ser Glu Ala Gln Ala Glu Ala Met Arg Lys 
305                 310                 315                 320 
His Tyr Asp Asp Val Trp Ala Pro Ala Gln Ser Glu Lys Tyr Arg Val 
                325                 330                 335     
Lys Ala Asn Tyr Ile Asp Gln Leu Val Val Ile Thr Gly Gly Ser Ser 
            340                 345                 350         
Thr Ile Glu Pro Pro Val Gly Tyr Ser Lys Ile Glu Tyr Asp Leu Asn 
        355                 360                 365             
Ala Gly Ala Gly Gly Asp Phe Ile Tyr Leu Cys Tyr His Glu Gln Thr 
    370                 375                 380                 
Trp Gln Ala Asp Arg Pro Lys Asp Ala Val Thr Asp Ile Arg Ile Ile 
385                 390                 395                 400 
Phe Asn Lys Glu Pro Thr Pro Pro Gly Tyr Thr Lys Leu Pro Gln Asp 
                405                 410                 415     
Leu Asn Lys Gly Ala Gly Gly Asp Asp Val Phe Leu Cys Tyr Lys Thr 
            420                 425                 430         
Glu Ala Tyr Asn Thr Asp Thr Ala Ile Asn Lys Val Thr Val Ile Gly 
        435                 440                 445             
Gly Asn Asn Ala Asp Ile Asn Ala Pro Tyr Gly Tyr Leu Lys Val Pro 
    450                 455                 460                 
Gly Asp Leu Asn Arg Gly Ala Gly Gly Asn Phe Ile Tyr Ala Cys Thr 
465                 470                 475                 480 
Phe Val Gly Lys 
                

<210>  378
<211>  1449
<212>  DNA
<213>  Unknown

<220>
<223>  Identified from a pool of bacterial strains

<400>  378
atgcagatcg tcgacttacc gaaaggacgc gtcaacttct ccgctaatca ccacctgcag       60
ttgttacgct tcaaggcagg cctaagcgaa gatgtgcttc cgggcgtaga agccattgga      120
ctgagctaca acccgttcct gagctacgca agtgtggaca gcggagccgt ccaactcttc      180
gactggtaca gtgcgaagaa gaaaaatgtg tcgttcaagc cgggttttgt cgtccctgaa      240
atcgtcgacg ttcagcagaa tgatagtgca agctacacaa acatcagtgg cagcactatt      300
tccgagtacc agaaaaacct tgcaaccagc gtggccattg aagggaagta caacttcttt      360
agcggatcgc tctccaccga ctacgatgaa aactcgttgc gcaatgccga aagcgagttt      420
agccgtatcc agcagtcgat taatctctgg tcgctgcgac tgccatcggt gaagttacta      480
cgtgacctca tgctgccgca catgcgggag cagttggacg agctggatgt aacgaagccg      540
gaggccgtca gcaagtattt tgatgatgtg ggcagccact ttctgaccgg catcgtgatg      600
ggaggacggg ccatactcgc ctcatcgacg aacaagctga cggtcaaacg cgactactcg      660
atttcggtcg tcgccaaagc cagctacgaa ggtttgaccg gtcagttgag tgcagaagcc      720
aaggccaagt acggcgaatc catcagcagc ttcacccaga actccaatac ccaccaggaa      780
gtccggggtg gcgacggcac caaagcgcat ggcgtgttca acggccagga aggcttccag      840
acatgggtcg acagcgttgg tgcttcgccc gacttcatag acttcgtgcc gacaattccg      900
atgcaggaaa tctggagctt gtgcaaaacc gacgaacaag ctgacgcgat gaaattgcat      960
tacgaaacga tatgggcgcc cgcgcaatcg gagaaatacc ggctaaagcc gaactacatt     1020
gaccaactgg tggtgattac cggcggtagt tcgaccatcg aaccgcctgc tggctatgcc     1080
aaggttccct acgacctcaa tactggtgcc ggcggcgatt tcatctacct ttgctaccac     1140
gagcaagcgt gggagccgga caaccttaaa ccggccgtga ccgcgatcca gatcatttat     1200
aaccaggagg taacaccgga aggctatatc aaattgcctc aagacctgaa caaaggcgca     1260
ggcggtgatg atgtgtatct ctgctacaaa tccgacacct acgacaccaa taacgcggtc     1320
aacaaagtca ccgttatcgg cggcggcaac gccgatatca atgcgcccta tggttacgac     1380
aaggtgccgg gagatttgaa cagaggcgcc ggtggcgaat tcgtctatgt ttgcacgttt     1440
gtaggcaga                                                             1449

<210>  379
<211>  483
<212>  PRT
<213>  Unknown

<220>
<223>  Identified from a pool of bacterial strains

<400>  379
Met Gln Ile Val Asp Leu Pro Lys Gly Arg Val Asn Phe Ser Ala Asn 
1               5                   10                  15      
His His Leu Gln Leu Leu Arg Phe Lys Ala Gly Leu Ser Glu Asp Val 
            20                  25                  30          
Leu Pro Gly Val Glu Ala Ile Gly Leu Ser Tyr Asn Pro Phe Leu Ser 
        35                  40                  45              
Tyr Ala Ser Val Asp Ser Gly Ala Val Gln Leu Phe Asp Trp Tyr Ser 
    50                  55                  60                  
Ala Lys Lys Lys Asn Val Ser Phe Lys Pro Gly Phe Val Val Pro Glu 
65                  70                  75                  80  
Ile Val Asp Val Gln Gln Asn Asp Ser Ala Ser Tyr Thr Asn Ile Ser 
                85                  90                  95      
Gly Ser Thr Ile Ser Glu Tyr Gln Lys Asn Leu Ala Thr Ser Val Ala 
            100                 105                 110         
Ile Glu Gly Lys Tyr Asn Phe Phe Ser Gly Ser Leu Ser Thr Asp Tyr 
        115                 120                 125             
Asp Glu Asn Ser Leu Arg Asn Ala Glu Ser Glu Phe Ser Arg Ile Gln 
    130                 135                 140                 
Gln Ser Ile Asn Leu Trp Ser Leu Arg Leu Pro Ser Val Lys Leu Leu 
145                 150                 155                 160 
Arg Asp Leu Met Leu Pro His Met Arg Glu Gln Leu Asp Glu Leu Asp 
                165                 170                 175     
Val Thr Lys Pro Glu Ala Val Ser Lys Tyr Phe Asp Asp Val Gly Ser 
            180                 185                 190         
His Phe Leu Thr Gly Ile Val Met Gly Gly Arg Ala Ile Leu Ala Ser 
        195                 200                 205             
Ser Thr Asn Lys Leu Thr Val Lys Arg Asp Tyr Ser Ile Ser Val Val 
    210                 215                 220                 
Ala Lys Ala Ser Tyr Glu Gly Leu Thr Gly Gln Leu Ser Ala Glu Ala 
225                 230                 235                 240 
Lys Ala Lys Tyr Gly Glu Ser Ile Ser Ser Phe Thr Gln Asn Ser Asn 
                245                 250                 255     
Thr His Gln Glu Val Arg Gly Gly Asp Gly Thr Lys Ala His Gly Val 
            260                 265                 270         
Phe Asn Gly Gln Glu Gly Phe Gln Thr Trp Val Asp Ser Val Gly Ala 
        275                 280                 285             
Ser Pro Asp Phe Ile Asp Phe Val Pro Thr Ile Pro Met Gln Glu Ile 
    290                 295                 300                 
Trp Ser Leu Cys Lys Thr Asp Glu Gln Ala Asp Ala Met Lys Leu His 
305                 310                 315                 320 
Tyr Glu Thr Ile Trp Ala Pro Ala Gln Ser Glu Lys Tyr Arg Leu Lys 
                325                 330                 335     
Pro Asn Tyr Ile Asp Gln Leu Val Val Ile Thr Gly Gly Ser Ser Thr 
            340                 345                 350         
Ile Glu Pro Pro Ala Gly Tyr Ala Lys Val Pro Tyr Asp Leu Asn Thr 
        355                 360                 365             
Gly Ala Gly Gly Asp Phe Ile Tyr Leu Cys Tyr His Glu Gln Ala Trp 
    370                 375                 380                 
Glu Pro Asp Asn Leu Lys Pro Ala Val Thr Ala Ile Gln Ile Ile Tyr 
385                 390                 395                 400 
Asn Gln Glu Val Thr Pro Glu Gly Tyr Ile Lys Leu Pro Gln Asp Leu 
                405                 410                 415     
Asn Lys Gly Ala Gly Gly Asp Asp Val Tyr Leu Cys Tyr Lys Ser Asp 
            420                 425                 430         
Thr Tyr Asp Thr Asn Asn Ala Val Asn Lys Val Thr Val Ile Gly Gly 
        435                 440                 445             
Gly Asn Ala Asp Ile Asn Ala Pro Tyr Gly Tyr Asp Lys Val Pro Gly 
    450                 455                 460                 
Asp Leu Asn Arg Gly Ala Gly Gly Glu Phe Val Tyr Val Cys Thr Phe 
465                 470                 475                 480 
Val Gly Arg 
            

<210>  380
<211>  1512
<212>  DNA
<213>  Pseudomonas monteilii

<400>  380
atgctggttc cttgctcgtt tgctgagcgg ttatatctgc ccataacaca taaggaaatc       60
atcatggaaa acatcgactt gccgcaagga cttgtgcact tttccaccca acacctgcaa      120
cttattcgtt ttaaagcagg tttggatgaa aaagtactgc cgggcgtcga agctatcgga      180
cttggctata acccattcat cagttatgcc agtgtcaaca gcggcgcggt gcagttgttc      240
gattggacca cggcgaaaaa acgcgaagta tcattcaagc caggctactt cgttccggag      300
atcgtcgacg tccagcagaa cgacagcgcc acctatacca acgtcaccgg cagcaccatt      360
accgagtacc agcgcagcct ggccaccagc gtggccatcg aggggcgcta caacttcttc      420
agcggctcgc tctccaccga cttcgacagc aactcgctgc gcaacgcgga aaacgaattc      480
agccgcatcc agcagtcgat caacctctgg tcgctgcgcc tgccttcggt cacgtcgctg      540
cgcgaattga tgctgccata catgcgccag caactcgacg agctcaacgt caatgatccc      600
aaggctatca gccgctattt cgacagggtc ggcagccatt tcctgaccgg tatcgtgatg      660
ggcggacggg ccatcctcgc ctcctcgacc aacaagctgc gggtcaagcg cgactactcg      720
gtggcggtag tggccaaggc cagctacgaa gggctcaccg gccagctgag cgccgaagcc      780
aaggccaagt acggcgagtc gatcagcagc ttcacccagt actccaatac ccaccaggaa      840
gtccgcggcg gtgacggcac caaggcacag gccgtgttca gtggcaagga agggttccag      900
gcctgggtcg acagcgtggg gacctcgccg gacttcgttg atttcgtccc gaccattccc      960
atgcaggaaa tctggagcct gtgcaagacc gaggcgcaag ccgaagccat gcgcaagcac     1020
tacgatgacg tttgggcgcc ggcacagtcg gaaaaatacc ggatcaaggc gaactacatc     1080
gaccagctgg tggtgatcac cggcggcagc tcgaccatcg aacctccggt gggctacagc     1140
aaggtggagt acgacctcaa cgctggcgcc ggtggcgact tcatctacct gtgctatcac     1200
gagcaagcct ggcaggccga ccagccgaag agcgccgtga ccgacatcag gatcatctac     1260
aacaaggagc cgaccccggc gggctacatc aagctgcccc aggacctgaa caagggcgcc     1320
ggcggcgatg atgtgttcct ctgctacaag accgaggcct acaacaccga caccgcaatc     1380
aacaaggtga cggtcatcgg tggtggcaat gccgatatca acgcacccta cggctacaag     1440
aagatacccg gcgacctcaa ccgcggggcc ggcggcaact tcatctacgc ctgcaccttc     1500
gtcggcaagt ag                                                         1512

<210>  381
<211>  1413
<212>  DNA
<213>  Clavibacter michiganensis

<400>  381
atgtctgact tcttcgtgac tgaaaccgac actccacgca ttcttccagg ggtcagcttg       60
accggctcca cgtacgacgt gttcggagac gatgccacca acgactccgc catattccag      120
atcttcgatt ggagcaaggc ggaatgggga accaccgaga tcaacggaac cgagtacagg      180
atcccgaagc tgatgaacgc tgaaggcgtc gcggggagcg aatacgtctc catctacggc      240
aacaccgtcg aggaatacca gcagagcctc gccgcgtccg tggcggtctc gggatccaac      300
atgttcttca gcggctcgtt ggagacgcag ttcggctcca gctcgatgcg gaggtcggag      360
aacgcgttct cccgcgtaga gcaggtcgtc aagctgtggt cgatcggcct gcctccgagc      420
aagaagctgc gagagctcct cagcggcagc ttcctggaag ccctcgacgg gctccccgcg      480
gcagcatcga cgagcgaaga gcaggcggag tacaagggct tcctcgacac gtggggcgcg      540
ttctacctct ccgggatgct gatcggcggc aagaccttgt tcacctcctc cgtgaacaag      600
ctcaccgtgg acaggacgct ctcgatctcg gtcacagcgg acttgtcata caagtcggtg      660
acaggccaga tcagcaacga ggacaagatc aagtacgcct cccagctctc gcagttcgct      720
tcgagctcca acacggtaaa gaatgcattc ggtgggaacc cggctctcgc ctcacgcgta      780
ttcgacggcc gcgtgcagta cgacgagtgg tcggcatccg tcgcccagaa ccccgtcatc      840
gtccgcttcg acggaacccg gcccctgacc ggcgtgtgga ctctctgctc gacgccggag      900
cgggggaaga tcctggagtc ctacttcgac gacaagtggg cacccgcgcg ttcgctcgaa      960
ctatcccact tccccgacgt ggtcgatgac ctcaccgtcg tggtgggcaa cgacgatcag     1020
ccccctgtac cggacggcta cacgaaggac gactacgacc tcaacaggca cgcaggcgga     1080
aagttcatct atctctgctg gcacaaggtg ccggtctccg gattgaggaa gccgaagcgc     1140
gtgcttcaag ccatgcaggt gatctacaac ggcgacaagg tgccggacgg gtactcgaag     1200
atcaacgtcg atctcaacca aggcgcaggc ggtgatgacg tgttcctctg catgaagcag     1260
ggcgaatacg gcacggacga gaacattctc gacgtgcggg tgatcggtgg caacgacagc     1320
ttcgtgcccg cgccttacgg ctacaagacc cttcccgggg atctgaacaa gggggccggc     1380
ggcgactacg tctacatcgc ctacgccaat tga                                  1413

<210>  382
<211>  1470
<212>  DNA
<213>  Serratia proteamaculans

<400>  382
atgaaaattg aatcatccaa ggttgaaggt ttgtttagct catcttttac tcgtgttaat       60
gctgtccctc tcccgagcga tactttaccc ggcgtaggta ttattggttg tggctacaat      120
ccatttttag cctatgcaga tgcttctgct gtcctgcatc ctattctcga ctggtcaaaa      180
tctcagttta acgaaattac tatgaacggt cagcaatatc aattacctga tgtgcttcag      240
gcggtatggc tcagtaacca gtcttacgca tcggtaacgg ggaaatcgct ccaaagttat      300
ttaactgaat tggctaacag tattaaagta agtggtaact atggcttttt tagtgcctca      360
gccacaaatg aatttagcga cagttcattg agaaagtcag aaaatgagtt tagtcgatgt      420
cagcagtcat ttgatttgtg gtcaattagt atcccagccg atattgcaag gttgcaaaac      480
tatgtttcag atgattttat aaaactgatt aatgcaataa atccagaaag taaagattca      540
atagccactg tattcaacgt ttatggcagc catgttctaa tgagtggtgt tatgggcggg      600
aaagctcacg tatccgcctc agcaaacaag ttaacactca cccaaaaatt tgagatgagt      660
acgattgttc aggctaaata cgaacaacta acatcacaac ttagcgtcga agacaaactt      720
aagtattcag aagccttcga tagtttcagc gaaagcggta gttacacata tgatattcta      780
ggcggtagcc cttctttagg ggcgcttgtt tttaaaaata actcgcaagg tagtagtgac      840
gataatttaa aaaattggat acagtctatt tccagtatgc cggtgttgac caagttcata      900
gaccaaacct cgttaatgcc tgtatggcta ttgtgtgaag acaagacaaa agccgatgca      960
ttaaaaaaat attacgataa tacatggtca aaatcgcaga tggccgttgc cagtctcaga     1020
gcaaactaca tcgacgagct gacatttgtc ctgggtgaca actcagatat ccctgctcca     1080
gtcggataca ctaaagttcc gattgatctt aattctgatg ctgggggtaa atatgtctat     1140
ctttgctatc atgaagcgca gttcacgcca gtaaatggca aacagccgat tgttgatatc     1200
caagtgctct atggtagcca gatgccagcg cctggatata taaaaattga tgttgatttg     1260
aatagcggtg ctggcgggga atttgtctac ctttcataca aaaagggaga accaacgtcg     1320
tccgatgtaa ttaataaaat caccgctgta tatggaaaaa atgagtacgt cccaacccca     1380
tatggatata aacaaattag cggtgacctt aatgctggag caggcggtga ctttgtttac     1440
ctctgtactt accaaggtgg tacagaataa                                      1470

<210>  383
<211>  1461
<212>  DNA
<213>  Marinomonas sp.

<400>  383
atgactttat tttttaaatc taaaaaccat aaaaagggaa aatttatgaa caacagagct       60
tttcatgaaa agtttcaagt agctgagtta aattcggacg ccaactatct ttcaggtgtt      120
agctctttag gatgtggcta tgatgtcttt ggagaatatg caactccgat atcaattact      180
tttccattat ttgattggac aaaagtacct accagagctg taacttttta taagggaaaa      240
gtgataccta acatagtaag tgccgtacaa cttgaaactt ccaattacaa agaaatatca      300
ggcagctcaa ttgaagagta cataaaaaac ttaaatactt atacaaaact tgaaggaagt      360
tacagctttt acagtggctc cgtttctgtc ggctataatg caagtgagta tagaaatgct      420
aaaaacgagt tttcacttat tcagcaagac attgctaaat gggctttaaa gtttactcct      480
gaaacagctc ttaactacat caaagatgac gtaaaaaatg atatagctga tatggaccca      540
attcagttat ttaaaagata tggtacacac ttcctatcag cgattgtaat tggcggcaaa      600
tcaatgatga cttccgcaac caatcaagta gattatcagt ccgaatatgg cattgatcta      660
actgcaaaac tagcttatga gagtcttact ttccagatca gcgcagaaaa taaaactaaa      720
tactctcaag aaatatctac ttttgaaagc cggtctaata ctgaagttag aacgtatgga      780
ggcagcgcag aaaaaggtgg tactaacatt ttgaaggaag gaggctttca ggaatggcaa      840
gatagcgttg gagacaatcc tacatttgta gattttgaca atgataatgc gcttacccca      900
atttgggaac tttgtgaaga tcaaaagaga aaagaagctt taattcacgc ttatgccacc      960
tttgcgaaag ggaaaacgtc tgagtgctta aatgtattca gtgctaattc tattactgaa     1020
ttaagagtaa tatcaggcga ctcaagcgtt atacagccac ctacagggta tattaaggac     1080
gactttgatc taaataaagg tgcaggagga aagttcattt atgtctgtta taaagaagat     1140
tcaactttag atattaaagc tgaaaagctg gatgtaataa ctgatataac aacaatttca     1200
ggtgacagcc ccgatattca agcacctgat ggttatataa aaataggtca agacttgaat     1260
gagggagcaa gaggtaaata tatttaccta tgctataaaa aaggcgagta ttcagaaaca     1320
gactctatca aggacataat ggtgataggc tcaagtcagc cacaaattta ccctccaata     1380
ggatttgaaa gaataaacca ggacctaaat caaggagctg gaggacttta catctacatg     1440
tgttattcaa gaacattgta g                                               1461

<210>  384
<211>  503
<212>  PRT
<213>  Pseudomonas monteilii

<400>  384
Met Leu Val Pro Cys Ser Phe Ala Glu Arg Leu Tyr Leu Pro Ile Thr 
1               5                   10                  15      
His Lys Glu Ile Ile Met Glu Asn Ile Asp Leu Pro Gln Gly Leu Val 
            20                  25                  30          
His Phe Ser Thr Gln His Leu Gln Leu Ile Arg Phe Lys Ala Gly Leu 
        35                  40                  45              
Asp Glu Lys Val Leu Pro Gly Val Glu Ala Ile Gly Leu Gly Tyr Asn 
    50                  55                  60                  
Pro Phe Ile Ser Tyr Ala Ser Val Asn Ser Gly Ala Val Gln Leu Phe 
65                  70                  75                  80  
Asp Trp Thr Thr Ala Lys Lys Arg Glu Val Ser Phe Lys Pro Gly Tyr 
                85                  90                  95      
Phe Val Pro Glu Ile Val Asp Val Gln Gln Asn Asp Ser Ala Thr Tyr 
            100                 105                 110         
Thr Asn Val Thr Gly Ser Thr Ile Thr Glu Tyr Gln Arg Ser Leu Ala 
        115                 120                 125             
Thr Ser Val Ala Ile Glu Gly Arg Tyr Asn Phe Phe Ser Gly Ser Leu 
    130                 135                 140                 
Ser Thr Asp Phe Asp Ser Asn Ser Leu Arg Asn Ala Glu Asn Glu Phe 
145                 150                 155                 160 
Ser Arg Ile Gln Gln Ser Ile Asn Leu Trp Ser Leu Arg Leu Pro Ser 
                165                 170                 175     
Val Thr Ser Leu Arg Glu Leu Met Leu Pro Tyr Met Arg Gln Gln Leu 
            180                 185                 190         
Asp Glu Leu Asn Val Asn Asp Pro Lys Ala Ile Ser Arg Tyr Phe Asp 
        195                 200                 205             
Arg Val Gly Ser His Phe Leu Thr Gly Ile Val Met Gly Gly Arg Ala 
    210                 215                 220                 
Ile Leu Ala Ser Ser Thr Asn Lys Leu Arg Val Lys Arg Asp Tyr Ser 
225                 230                 235                 240 
Val Ala Val Val Ala Lys Ala Ser Tyr Glu Gly Leu Thr Gly Gln Leu 
                245                 250                 255     
Ser Ala Glu Ala Lys Ala Lys Tyr Gly Glu Ser Ile Ser Ser Phe Thr 
            260                 265                 270         
Gln Tyr Ser Asn Thr His Gln Glu Val Arg Gly Gly Asp Gly Thr Lys 
        275                 280                 285             
Ala Gln Ala Val Phe Ser Gly Lys Glu Gly Phe Gln Ala Trp Val Asp 
    290                 295                 300                 
Ser Val Gly Thr Ser Pro Asp Phe Val Asp Phe Val Pro Thr Ile Pro 
305                 310                 315                 320 
Met Gln Glu Ile Trp Ser Leu Cys Lys Thr Glu Ala Gln Ala Glu Ala 
                325                 330                 335     
Met Arg Lys His Tyr Asp Asp Val Trp Ala Pro Ala Gln Ser Glu Lys 
            340                 345                 350         
Tyr Arg Ile Lys Ala Asn Tyr Ile Asp Gln Leu Val Val Ile Thr Gly 
        355                 360                 365             
Gly Ser Ser Thr Ile Glu Pro Pro Val Gly Tyr Ser Lys Val Glu Tyr 
    370                 375                 380                 
Asp Leu Asn Ala Gly Ala Gly Gly Asp Phe Ile Tyr Leu Cys Tyr His 
385                 390                 395                 400 
Glu Gln Ala Trp Gln Ala Asp Gln Pro Lys Ser Ala Val Thr Asp Ile 
                405                 410                 415     
Arg Ile Ile Tyr Asn Lys Glu Pro Thr Pro Ala Gly Tyr Ile Lys Leu 
            420                 425                 430         
Pro Gln Asp Leu Asn Lys Gly Ala Gly Gly Asp Asp Val Phe Leu Cys 
        435                 440                 445             
Tyr Lys Thr Glu Ala Tyr Asn Thr Asp Thr Ala Ile Asn Lys Val Thr 
    450                 455                 460                 
Val Ile Gly Gly Gly Asn Ala Asp Ile Asn Ala Pro Tyr Gly Tyr Lys 
465                 470                 475                 480 
Lys Ile Pro Gly Asp Leu Asn Arg Gly Ala Gly Gly Asn Phe Ile Tyr 
                485                 490                 495     
Ala Cys Thr Phe Val Gly Lys 
            500             

<210>  385
<211>  470
<212>  PRT
<213>  Clavibacter michiganensis

<400>  385
Met Ser Asp Phe Phe Val Thr Glu Thr Asp Thr Pro Arg Ile Leu Pro 
1               5                   10                  15      
Gly Val Ser Leu Thr Gly Ser Thr Tyr Asp Val Phe Gly Asp Asp Ala 
            20                  25                  30          
Thr Asn Asp Ser Ala Ile Phe Gln Ile Phe Asp Trp Ser Lys Ala Glu 
        35                  40                  45              
Trp Gly Thr Thr Glu Ile Asn Gly Thr Glu Tyr Arg Ile Pro Lys Leu 
    50                  55                  60                  
Met Asn Ala Glu Gly Val Ala Gly Ser Glu Tyr Val Ser Ile Tyr Gly 
65                  70                  75                  80  
Asn Thr Val Glu Glu Tyr Gln Gln Ser Leu Ala Ala Ser Val Ala Val 
                85                  90                  95      
Ser Gly Ser Asn Met Phe Phe Ser Gly Ser Leu Glu Thr Gln Phe Gly 
            100                 105                 110         
Ser Ser Ser Met Arg Arg Ser Glu Asn Ala Phe Ser Arg Val Glu Gln 
        115                 120                 125             
Val Val Lys Leu Trp Ser Ile Gly Leu Pro Pro Ser Lys Lys Leu Arg 
    130                 135                 140                 
Glu Leu Leu Ser Gly Ser Phe Leu Glu Ala Leu Asp Gly Leu Pro Ala 
145                 150                 155                 160 
Ala Ala Ser Thr Ser Glu Glu Gln Ala Glu Tyr Lys Gly Phe Leu Asp 
                165                 170                 175     
Thr Trp Gly Ala Phe Tyr Leu Ser Gly Met Leu Ile Gly Gly Lys Thr 
            180                 185                 190         
Leu Phe Thr Ser Ser Val Asn Lys Leu Thr Val Asp Arg Thr Leu Ser 
        195                 200                 205             
Ile Ser Val Thr Ala Asp Leu Ser Tyr Lys Ser Val Thr Gly Gln Ile 
    210                 215                 220                 
Ser Asn Glu Asp Lys Ile Lys Tyr Ala Ser Gln Leu Ser Gln Phe Ala 
225                 230                 235                 240 
Ser Ser Ser Asn Thr Val Lys Asn Ala Phe Gly Gly Asn Pro Ala Leu 
                245                 250                 255     
Ala Ser Arg Val Phe Asp Gly Arg Val Gln Tyr Asp Glu Trp Ser Ala 
            260                 265                 270         
Ser Val Ala Gln Asn Pro Val Ile Val Arg Phe Asp Gly Thr Arg Pro 
        275                 280                 285             
Leu Thr Gly Val Trp Thr Leu Cys Ser Thr Pro Glu Arg Gly Lys Ile 
    290                 295                 300                 
Leu Glu Ser Tyr Phe Asp Asp Lys Trp Ala Pro Ala Arg Ser Leu Glu 
305                 310                 315                 320 
Leu Ser His Phe Pro Asp Val Val Asp Asp Leu Thr Val Val Val Gly 
                325                 330                 335     
Asn Asp Asp Gln Pro Pro Val Pro Asp Gly Tyr Thr Lys Asp Asp Tyr 
            340                 345                 350         
Asp Leu Asn Arg His Ala Gly Gly Lys Phe Ile Tyr Leu Cys Trp His 
        355                 360                 365             
Lys Val Pro Val Ser Gly Leu Arg Lys Pro Lys Arg Val Leu Gln Ala 
    370                 375                 380                 
Met Gln Val Ile Tyr Asn Gly Asp Lys Val Pro Asp Gly Tyr Ser Lys 
385                 390                 395                 400 
Ile Asn Val Asp Leu Asn Gln Gly Ala Gly Gly Asp Asp Val Phe Leu 
                405                 410                 415     
Cys Met Lys Gln Gly Glu Tyr Gly Thr Asp Glu Asn Ile Leu Asp Val 
            420                 425                 430         
Arg Val Ile Gly Gly Asn Asp Ser Phe Val Pro Ala Pro Tyr Gly Tyr 
        435                 440                 445             
Lys Thr Leu Pro Gly Asp Leu Asn Lys Gly Ala Gly Gly Asp Tyr Val 
    450                 455                 460                 
Tyr Ile Ala Tyr Ala Asn 
465                 470 

<210>  386
<211>  489
<212>  PRT
<213>  Serratia proteamaculans

<400>  386
Met Lys Ile Glu Ser Ser Lys Val Glu Gly Leu Phe Ser Ser Ser Phe 
1               5                   10                  15      
Thr Arg Val Asn Ala Val Pro Leu Pro Ser Asp Thr Leu Pro Gly Val 
            20                  25                  30          
Gly Ile Ile Gly Cys Gly Tyr Asn Pro Phe Leu Ala Tyr Ala Asp Ala 
        35                  40                  45              
Ser Ala Val Leu His Pro Ile Leu Asp Trp Ser Lys Ser Gln Phe Asn 
    50                  55                  60                  
Glu Ile Thr Met Asn Gly Gln Gln Tyr Gln Leu Pro Asp Val Leu Gln 
65                  70                  75                  80  
Ala Val Trp Leu Ser Asn Gln Ser Tyr Ala Ser Val Thr Gly Lys Ser 
                85                  90                  95      
Leu Gln Ser Tyr Leu Thr Glu Leu Ala Asn Ser Ile Lys Val Ser Gly 
            100                 105                 110         
Asn Tyr Gly Phe Phe Ser Ala Ser Ala Thr Asn Glu Phe Ser Asp Ser 
        115                 120                 125             
Ser Leu Arg Lys Ser Glu Asn Glu Phe Ser Arg Cys Gln Gln Ser Phe 
    130                 135                 140                 
Asp Leu Trp Ser Ile Ser Ile Pro Ala Asp Ile Ala Arg Leu Gln Asn 
145                 150                 155                 160 
Tyr Val Ser Asp Asp Phe Ile Lys Leu Ile Asn Ala Ile Asn Pro Glu 
                165                 170                 175     
Ser Lys Asp Ser Ile Ala Thr Val Phe Asn Val Tyr Gly Ser His Val 
            180                 185                 190         
Leu Met Ser Gly Val Met Gly Gly Lys Ala His Val Ser Ala Ser Ala 
        195                 200                 205             
Asn Lys Leu Thr Leu Thr Gln Lys Phe Glu Met Ser Thr Ile Val Gln 
    210                 215                 220                 
Ala Lys Tyr Glu Gln Leu Thr Ser Gln Leu Ser Val Glu Asp Lys Leu 
225                 230                 235                 240 
Lys Tyr Ser Glu Ala Phe Asp Ser Phe Ser Glu Ser Gly Ser Tyr Thr 
                245                 250                 255     
Tyr Asp Ile Leu Gly Gly Ser Pro Ser Leu Gly Ala Leu Val Phe Lys 
            260                 265                 270         
Asn Asn Ser Gln Gly Ser Ser Asp Asp Asn Leu Lys Asn Trp Ile Gln 
        275                 280                 285             
Ser Ile Ser Ser Met Pro Val Leu Thr Lys Phe Ile Asp Gln Thr Ser 
    290                 295                 300                 
Leu Met Pro Val Trp Leu Leu Cys Glu Asp Lys Thr Lys Ala Asp Ala 
305                 310                 315                 320 
Leu Lys Lys Tyr Tyr Asp Asn Thr Trp Ser Lys Ser Gln Met Ala Val 
                325                 330                 335     
Ala Ser Leu Arg Ala Asn Tyr Ile Asp Glu Leu Thr Phe Val Leu Gly 
            340                 345                 350         
Asp Asn Ser Asp Ile Pro Ala Pro Val Gly Tyr Thr Lys Val Pro Ile 
        355                 360                 365             
Asp Leu Asn Ser Asp Ala Gly Gly Lys Tyr Val Tyr Leu Cys Tyr His 
    370                 375                 380                 
Glu Ala Gln Phe Thr Pro Val Asn Gly Lys Gln Pro Ile Val Asp Ile 
385                 390                 395                 400 
Gln Val Leu Tyr Gly Ser Gln Met Pro Ala Pro Gly Tyr Ile Lys Ile 
                405                 410                 415     
Asp Val Asp Leu Asn Ser Gly Ala Gly Gly Glu Phe Val Tyr Leu Ser 
            420                 425                 430         
Tyr Lys Lys Gly Glu Pro Thr Ser Ser Asp Val Ile Asn Lys Ile Thr 
        435                 440                 445             
Ala Val Tyr Gly Lys Asn Glu Tyr Val Pro Thr Pro Tyr Gly Tyr Lys 
    450                 455                 460                 
Gln Ile Ser Gly Asp Leu Asn Ala Gly Ala Gly Gly Asp Phe Val Tyr 
465                 470                 475                 480 
Leu Cys Thr Tyr Gln Gly Gly Thr Glu 
                485                 

<210>  387
<211>  486
<212>  PRT
<213>  Marinomonas sp

<400>  387
Met Thr Leu Phe Phe Lys Ser Lys Asn His Lys Lys Gly Lys Phe Met 
1               5                   10                  15      
Asn Asn Arg Ala Phe His Glu Lys Phe Gln Val Ala Glu Leu Asn Ser 
            20                  25                  30          
Asp Ala Asn Tyr Leu Ser Gly Val Ser Ser Leu Gly Cys Gly Tyr Asp 
        35                  40                  45              
Val Phe Gly Glu Tyr Ala Thr Pro Ile Ser Ile Thr Phe Pro Leu Phe 
    50                  55                  60                  
Asp Trp Thr Lys Val Pro Thr Arg Ala Val Thr Phe Tyr Lys Gly Lys 
65                  70                  75                  80  
Val Ile Pro Asn Ile Val Ser Ala Val Gln Leu Glu Thr Ser Asn Tyr 
                85                  90                  95      
Lys Glu Ile Ser Gly Ser Ser Ile Glu Glu Tyr Ile Lys Asn Leu Asn 
            100                 105                 110         
Thr Tyr Thr Lys Leu Glu Gly Ser Tyr Ser Phe Tyr Ser Gly Ser Val 
        115                 120                 125             
Ser Val Gly Tyr Asn Ala Ser Glu Tyr Arg Asn Ala Lys Asn Glu Phe 
    130                 135                 140                 
Ser Leu Ile Gln Gln Asp Ile Ala Lys Trp Ala Leu Lys Phe Thr Pro 
145                 150                 155                 160 
Glu Thr Ala Leu Asn Tyr Ile Lys Asp Asp Val Lys Asn Asp Ile Ala 
                165                 170                 175     
Asp Met Asp Pro Ile Gln Leu Phe Lys Arg Tyr Gly Thr His Phe Leu 
            180                 185                 190         
Ser Ala Ile Val Ile Gly Gly Lys Ser Met Met Thr Ser Ala Thr Asn 
        195                 200                 205             
Gln Val Asp Tyr Gln Ser Glu Tyr Gly Ile Asp Leu Thr Ala Lys Leu 
    210                 215                 220                 
Ala Tyr Glu Ser Leu Thr Phe Gln Ile Ser Ala Glu Asn Lys Thr Lys 
225                 230                 235                 240 
Tyr Ser Gln Glu Ile Ser Thr Phe Glu Ser Arg Ser Asn Thr Glu Val 
                245                 250                 255     
Arg Thr Tyr Gly Gly Ser Ala Glu Lys Gly Gly Thr Asn Ile Leu Lys 
            260                 265                 270         
Glu Gly Gly Phe Gln Glu Trp Gln Asp Ser Val Gly Asp Asn Pro Thr 
        275                 280                 285             
Phe Val Asp Phe Asp Asn Asp Asn Ala Leu Thr Pro Ile Trp Glu Leu 
    290                 295                 300                 
Cys Glu Asp Gln Lys Arg Lys Glu Ala Leu Ile His Ala Tyr Ala Thr 
305                 310                 315                 320 
Phe Ala Lys Gly Lys Thr Ser Glu Cys Leu Asn Val Phe Ser Ala Asn 
                325                 330                 335     
Ser Ile Thr Glu Leu Arg Val Ile Ser Gly Asp Ser Ser Val Ile Gln 
            340                 345                 350         
Pro Pro Thr Gly Tyr Ile Lys Asp Asp Phe Asp Leu Asn Lys Gly Ala 
        355                 360                 365             
Gly Gly Lys Phe Ile Tyr Val Cys Tyr Lys Glu Asp Ser Thr Leu Asp 
    370                 375                 380                 
Ile Lys Ala Glu Lys Leu Asp Val Ile Thr Asp Ile Thr Thr Ile Ser 
385                 390                 395                 400 
Gly Asp Ser Pro Asp Ile Gln Ala Pro Asp Gly Tyr Ile Lys Ile Gly 
                405                 410                 415     
Gln Asp Leu Asn Glu Gly Ala Arg Gly Lys Tyr Ile Tyr Leu Cys Tyr 
            420                 425                 430         
Lys Lys Gly Glu Tyr Ser Glu Thr Asp Ser Ile Lys Asp Ile Met Val 
        435                 440                 445             
Ile Gly Ser Ser Gln Pro Gln Ile Tyr Pro Pro Ile Gly Phe Glu Arg 
    450                 455                 460                 
Ile Asn Gln Asp Leu Asn Gln Gly Ala Gly Gly Leu Tyr Ile Tyr Met 
465                 470                 475                 480 
Cys Tyr Ser Arg Thr Leu 
                485     

<210>  388
<211>  488
<212>  PRT
<213>  Serratia plymuthica

<400>  388
Met Lys Phe Glu Ser Leu Lys Val Glu Asn Leu Phe Ser Ser Ser Leu 
1               5                   10                  15      
Thr Arg Ile Asn Ala Ile Pro Leu Pro Asn Asp Ala Leu Pro Gly Val 
            20                  25                  30          
Gly Ile Ile Gly Cys Gly Tyr Asn Pro Phe Leu Ala Tyr Ala Asp Ser 
        35                  40                  45              
Ser Ala Val Leu His Pro Val Leu Asp Trp Ser Lys Ser Gln Phe His 
    50                  55                  60                  
Thr Val Thr Met Asn Gly Gln Thr Tyr Gln Leu Pro Glu Ile Leu Asn 
65                  70                  75                  80  
Ala Val Trp Leu Ser Asn Gln Thr Tyr Ser Ser Val Ser Gly Lys Ser 
                85                  90                  95      
Leu Gln Ser Tyr Leu Thr Glu Leu Ser Asn Ser Ile Lys Val Ser Gly 
            100                 105                 110         
Asn Tyr Gly Phe Phe Ser Ala Ser Ala Thr Asn Glu Phe Thr Asp Ser 
        115                 120                 125             
Ser Leu Arg Lys Ser Glu Asn Glu Phe Ser Arg Cys Gln Gln Ser Phe 
    130                 135                 140                 
Asp Leu Trp Ser Ile Ser Ala Pro Ala Asp Ile Ala Arg Leu Gln Asn 
145                 150                 155                 160 
Tyr Ile Ser Asp Asp Phe Lys Lys Leu Ile Ser Ser Ile Asp Pro Asn 
                165                 170                 175     
Asn Gln Gln Thr Leu Ala Thr Ile Phe Asn Val Tyr Gly Ser His Ile 
            180                 185                 190         
Leu Met Ser Gly Val Met Gly Gly Lys Ala His Val Ser Ala Ser Ala 
        195                 200                 205             
Asn Lys Leu Thr Leu Thr Gln Lys Phe Glu Met Ser Thr Ile Val Gln 
    210                 215                 220                 
Ala Lys Tyr Glu Gln Leu Thr Ser Gln Leu Ser Ala Glu Asp Lys Leu 
225                 230                 235                 240 
Lys Tyr Ser Glu Ala Phe Glu Ser Phe Ser Glu Ser Gly Ser Tyr Thr 
                245                 250                 255     
Tyr Asp Ile Leu Gly Gly Ser Pro Ser Leu Gly Ala Leu Val Phe Lys 
            260                 265                 270         
Val Asn Asn Gln Asp Ser Asp Asp Asn Leu Arg Lys Trp Ile Asp Ser 
        275                 280                 285             
Ile Ser Thr Met Pro Val Leu Thr Lys Phe Ile Asp Gln Thr Ser Leu 
    290                 295                 300                 
Leu Pro Val Trp Thr Leu Cys Glu Asp Gln Val Lys Ala Asp Ala Leu 
305                 310                 315                 320 
Lys Asn Tyr Tyr Asn Asn Thr Trp Ser Gln Leu Gln Met Ala Val Ala 
                325                 330                 335     
Arg Leu Arg Ala Asn Tyr Ile Asp Glu Val Thr Phe Val Leu Gly Asp 
            340                 345                 350         
Asn Ser Asp Ile Pro Ala Pro Ala Gly Tyr Thr Lys Val Pro Val Asp 
        355                 360                 365             
Leu Asn Ser Gly Ala Gly Gly Lys Phe Ile Tyr Leu Cys Tyr His Glu 
    370                 375                 380                 
Ala Gln Phe Thr Pro Val Asn Ser Lys Gln Ala Ile Val Gly Leu Gln 
385                 390                 395                 400 
Val Leu Tyr Gly Lys Gln Glu Pro Ala Pro Asp Tyr Ser Arg Ile Asn 
                405                 410                 415     
Ile Asp Leu Asn Ser Gly Ala Asn Gly Asp Asp Val Tyr Leu Ser Tyr 
            420                 425                 430         
Lys Lys Gly Asp Ala Thr Ser Lys Glu Val Ile Asn Lys Ile Thr Ala 
        435                 440                 445             
Val Tyr Gly Lys Asp Gln Tyr Val Pro Thr Pro Tyr Gly Tyr Lys Gln 
    450                 455                 460                 
Ile Pro Gly Asp Leu Asn Ser Gly Ala Gly Gly Asp Phe Val Tyr Phe 
465                 470                 475                 480 
Cys Thr Tyr Gln Gly Gly Thr Glu 
                485             

