                               SEQUENCE LISTING

<110> UNIVERSITY OF KANSAS
 
<120> ELIMINATING MHC RESTRICTION FROM THE T CELL RECEPTOR AS A
      STRATEGY FOR IMMUNOTHERAPY

<130> 17-21007-WO

<140>
<141>

<150> 62/330,499
<151> 2016-05-02

<160> 41    

<170> PatentIn version 3.5

<210> 1
<211> 171
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 1
Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu Val Ala Gln Asn Val 
1               5                   10                  15      


Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala 
            20                  25                  30          


Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu Asp Thr Lys Glu 
        35                  40                  45              


Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe Phe Gln Leu Glu 
    50                  55                  60                  


Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser Val Ser Leu Ala 
65                  70                  75                  80  


Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala 
                85                  90                  95      


Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala 
            100                 105                 110         


Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala Gly Gln Arg Leu 
        115                 120                 125             


Gly Val His Leu His Thr Glu Ala Arg Ala Arg His Ala Trp Gln Leu 
    130                 135                 140                 


Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val Thr Pro Glu Ile 
145                 150                 155                 160 


Pro Ala Gly Leu Pro Ser Pro Arg Ser Asp His 
                165                 170     


<210> 2
<211> 516
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 2
ttggacctgc ggcagggcat gttcgcccag ctggtggctc agaacgtgct gctgatcgac       60

ggccccctga gctggtactc tgatcctgga ctggctggcg tgtccctgac cggcggactg      120

agctacaaag aggacacaaa agaactggtg gtggccaagg ccggcgtgta ctacgtgttc      180

tttcagctgg aactgcggag agtggtggcc ggcgagggat ctggatctgt gtctctggcc      240

ctgcatctgc agcccctgag atctgctgct ggcgcagctg ctctggctct gaccgtggat      300

ctgcctcctg ccagcagcga ggccagaaac agcgcattcg ggtttcaagg caggctgctg      360

cacctgagcg ccggacagag actgggagtg catctgcaca cagaggccag agccaggcac      420

gcctggcagc tgacacaggg cgctacagtg ctgggcctgt tcagagtgac ccccgagatt      480

cctgccggcc tgcctagccc tagaagcgac cactaa                                516


<210> 3
<211> 175
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3
Val Asp Leu Asn Lys Val Phe Pro Pro Glu Val Ala Val Phe Glu Pro 
1               5                   10                  15      


Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr Leu Val Cys Leu 
            20                  25                  30          


Ala Thr Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp Trp Val Asn 
        35                  40                  45              


Gly Lys Glu Val His Ser Gly Val Cys Thr Asp Pro Gln Pro Leu Lys 
    50                  55                  60                  


Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu Ser Ser Arg Leu 
65                  70                  75                  80  


Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn His Phe Arg Cys 
                85                  90                  95      


Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu Trp Thr Gln Asp 
            100                 105                 110         


Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu Ala Trp Gly Arg 
        115                 120                 125             


Ala Asp Cys Gly Phe Thr Ser Val Ser Tyr Gln Gln Gly Val Leu Ser 
    130                 135                 140                 


Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala 
145                 150                 155                 160 


Val Leu Val Ser Ala Leu Val Leu Met Ala Met Val Lys Arg Lys 
                165                 170                 175 


<210> 4
<211> 525
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 4
gtcgacctga acaaggtgtt cccacccgag gtcgctgtgt ttgagccatc agaagcagag       60

atatcccaca cccaaaaggc cacactggtg tgcctggcca caggcttctt ccccgaccac      120

gtggagctga gctggtgggt gaatgggaag gaggtgcaca gtggggtctg cacggacccg      180

cagcccctca aggagcagcc cgccctcaat gactccagat actgcctgag cagccgcctg      240

agggtctcgg ccaccttctg gcagaacccc cgcaaccact tccgctgtca agtccagttc      300

tacgggctct cggagaatga cgagtggacc caggataggg ccaaacccgt cacccagatc      360

gtcagcgccg aggcctgggg tagagcagac tgtggcttta cctcggtgtc ctaccagcaa      420

ggggtcctgt ctgccaccat cctctatgag atcctgctag ggaaggccac cctgtatgct      480

gtgctggtca gcgcccttgt gttgatggct atggtcaaga gaaag                      525


<210> 5
<211> 136
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 5
Pro Ala Val Tyr Gln Leu Arg Asp Ser Lys Ser Ser Asp Lys Ser Val 
1               5                   10                  15      


Cys Leu Phe Thr Asp Phe Asp Ser Gln Thr Asn Val Ser Gln Ser Lys 
            20                  25                  30          


Asp Ser Asp Val Tyr Ile Thr Asp Lys Cys Val Leu Asp Met Arg Ser 
        35                  40                  45              


Met Asp Phe Lys Ser Asn Ser Ala Val Ala Trp Ser Asn Lys Ser Asp 
    50                  55                  60                  


Phe Ala Cys Ala Asn Ala Phe Asn Asn Ser Ile Ile Pro Glu Asp Thr 
65                  70                  75                  80  


Phe Phe Pro Ser Pro Glu Ser Ser Cys Asp Val Lys Leu Val Glu Lys 
                85                  90                  95      


Ser Phe Glu Thr Asp Thr Asn Leu Asn Phe Gln Asn Leu Ser Val Ile 
            100                 105                 110         


Gly Phe Arg Ile Leu Leu Leu Lys Val Ala Gly Phe Asn Leu Leu Met 
        115                 120                 125             


Thr Leu Arg Leu Trp Ser Ser Ala 
    130                 135     


<210> 6
<211> 408
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 6
cctgccgtgt accagctgag agacagcaag agcagcgaca agagcgtgtg cctgttcacc       60

gacttcgaca gccagaccaa cgtgtcccag agcaaggaca gcgacgtgta catcaccgat      120

aagtgcgtgc tggacatgcg gagcatggac ttcaagagca acagcgccgt ggcctggtcc      180

aacaagagcg atttcgcctg cgccaacgcc ttcaacaaca gcattatccc cgaggacaca      240

ttcttcccaa gccccgagag cagctgcgac gtgaagctgg tggaaaagag cttcgagaca      300

gacaccaacc tgaacttcca gaacctgagc gtgatcggct tcagaatcct gctgctgaag      360

gtggccggct tcaacctgct gatgaccctg agactgtggt cctccgct                   408


<210> 7
<211> 174
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 7
ggcctaactg gccggcacct gagccagatg acggtggaaa aattgcatca tacagaaggc       60

ttggaggaaa aactgtttca atcactacgc tcggaggaaa atttgtatca ttgagatggc      120

ctcggcggcc agaagccggc tgtagagggt atataatgga agctcgaatt ccag            174


<210> 8
<211> 104
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 8
ggcacctgag ccagatgacg gtggaaaaat tgcatcatac agaaggcttg gaggaaaaac       60

tgtttcaatc actacgctcg gaggaaaatt tgtatcattg agat                       104


<210> 9
<211> 32
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 9
tagagggtat ataatggaag ctcgaattcc ag                                     32


<210> 10
<211> 1587
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 10
ggcctaactg gccggcacct gagccagatg acggtggaaa aattgcatca tacagaaggc       60

ttggaggaaa aactgtttca atcactacgc tcggaggaaa atttgtatca ttgagatggc      120

ctcggcggcc agaagccggc tgtagagggt atataatgga agctcgaatt ccagcctggc      180

cttccggtac tgttggtaga aggcctggca gagcggcacc gtgggaaagg ccaccatgtt      240

ggactttcaa gtgcagatct tcagcttcct gctgatctcc gccagcgtga tcatgagcag      300

aggccaggtg cagctggtgg aatctggacc tggcgtggtg cagccaggca gaagcctgag      360

aatcagctgt gccgtgtccg gcttcagcgt gaccaactac ggcgtgcact gggtgcgcca      420

gcctccaggc aaaggactgg aatggctggg cgtgatctgg gctggcggca tcaccaacta      480

caacagcgcc ttcatgagcc ggctgaccat cagcaaggac aacagcaaga acaccgtgta      540

cctgcagatg aacagcctgc gggccgagga caccgccatg tactactgtg ctagcagagg      600

cggccactac ggctacgccc tggattattg gggccagggc acactcgtga ccgtgtctag      660

cggaggcgga ggatctggcg gcggaggaag tggcggaggg ggatctgaga tcgtgatgac      720

ccagacccct gccaccctgt ctgtgtctgc cggcgagaga gtgaccatta cctgcaaggc      780

cagccagagc gtgtccaacg acgtgacctg gtatcagcag aagcccggcc aggcccccag      840

actgctgatc tacagcgcca gcaaccggta cagcggagtg cccgccagat tttccggcag      900

cggctacggc accgagttca ccttcaccat cagcagcgtg cagagcgagg acttcgccgt      960

gtacttctgt cagcaagact acagcagctt cggccagggc accaagctgg aaatcaagag     1020

atccggcgga ggctccggct acccctacga cgtgcccgac tatgcattgg acctgcggca     1080

gggcatgttc gcccagctgg tggctcagaa cgtgctgctg atcgacggcc ccctgagctg     1140

gtactctgat cctggactgg ctggcgtgtc cctgaccggc ggactgagct acaaagagga     1200

cacaaaagaa ctggtggtgg ccaaggccgg cgtgtactac gtgttctttc agctggaact     1260

gcggagagtg gtggccggcg agggatctgg atctgtgtct ctggccctgc atctgcagcc     1320

cctgagatct gctgctggcg cagctgctct ggctctgacc gtggatctgc ctcctgccag     1380

cagcgaggcc agaaacagcg cattcgggtt tcaaggcagg ctgctgcacc tgagcgccgg     1440

acagagactg ggagtgcatc tgcacacaga ggccagagcc aggcacgcct ggcagctgac     1500

acagggcgct acagtgctgg gcctgttcag agtgaccccc gagattcctg ccggcctgcc     1560

tagccctaga agcgaccact aagttgg                                         1587


<210> 11
<211> 448
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 11
Met Leu Asp Phe Gln Val Gln Ile Phe Ser Phe Leu Leu Ile Ser Ala 
1               5                   10                  15      


Ser Val Ile Met Ser Arg Gly Gln Val Gln Leu Val Glu Ser Gly Pro 
            20                  25                  30          


Gly Val Val Gln Pro Gly Arg Ser Leu Arg Ile Ser Cys Ala Val Ser 
        35                  40                  45              


Gly Phe Ser Val Thr Asn Tyr Gly Val His Trp Val Arg Gln Pro Pro 
    50                  55                  60                  


Gly Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Ala Gly Gly Ile Thr 
65                  70                  75                  80  


Asn Tyr Asn Ser Ala Phe Met Ser Arg Leu Thr Ile Ser Lys Asp Asn 
                85                  90                  95      


Ser Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
            100                 105                 110         


Thr Ala Met Tyr Tyr Cys Ala Ser Arg Gly Gly His Tyr Gly Tyr Ala 
        115                 120                 125             


Leu Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Val 
145                 150                 155                 160 


Met Thr Gln Thr Pro Ala Thr Leu Ser Val Ser Ala Gly Glu Arg Val 
                165                 170                 175     


Thr Ile Thr Cys Lys Ala Ser Gln Ser Val Ser Asn Asp Val Thr Trp 
            180                 185                 190         


Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Ser Ala 
        195                 200                 205             


Ser Asn Arg Tyr Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Tyr 
    210                 215                 220                 


Gly Thr Glu Phe Thr Phe Thr Ile Ser Ser Val Gln Ser Glu Asp Phe 
225                 230                 235                 240 


Ala Val Tyr Phe Cys Gln Gln Asp Tyr Ser Ser Phe Gly Gln Gly Thr 
                245                 250                 255     


Lys Leu Glu Ile Lys Arg Ser Gly Gly Gly Ser Gly Tyr Pro Tyr Asp 
            260                 265                 270         


Val Pro Asp Tyr Ala Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu 
        275                 280                 285             


Val Ala Gln Asn Val Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser 
    290                 295                 300                 


Asp Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys 
305                 310                 315                 320 


Glu Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val 
                325                 330                 335     


Phe Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly 
            340                 345                 350         


Ser Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly 
        355                 360                 365             


Ala Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu 
    370                 375                 380                 


Ala Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser 
385                 390                 395                 400 


Ala Gly Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg 
                405                 410                 415     


His Ala Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg 
            420                 425                 430         


Val Thr Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Asp His 
        435                 440                 445             


<210> 12
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 12
Tyr Pro Tyr Asp Val Pro Asp Tyr Ala 
1               5                   


<210> 13
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 13
tacccctacg acgtgcccga ctatgca                                           27


<210> 14
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 14
Ser Gly Gly Gly Ser Gly 
1               5       


<210> 15
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 15
tccggcggag gctccggc                                                     18


<210> 16
<211> 262
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 16
Met Leu Asp Phe Gln Val Gln Ile Phe Ser Phe Leu Leu Ile Ser Ala 
1               5                   10                  15      


Ser Val Ile Met Ser Arg Gly Gln Val Gln Leu Val Glu Ser Gly Pro 
            20                  25                  30          


Gly Val Val Gln Pro Gly Arg Ser Leu Arg Ile Ser Cys Ala Val Ser 
        35                  40                  45              


Gly Phe Ser Val Thr Asn Tyr Gly Val His Trp Val Arg Gln Pro Pro 
    50                  55                  60                  


Gly Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Ala Gly Gly Ile Thr 
65                  70                  75                  80  


Asn Tyr Asn Ser Ala Phe Met Ser Arg Leu Thr Ile Ser Lys Asp Asn 
                85                  90                  95      


Ser Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
            100                 105                 110         


Thr Ala Met Tyr Tyr Cys Ala Ser Arg Gly Gly His Tyr Gly Tyr Ala 
        115                 120                 125             


Leu Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Val 
145                 150                 155                 160 


Met Thr Gln Thr Pro Ala Thr Leu Ser Val Ser Ala Gly Glu Arg Val 
                165                 170                 175     


Thr Ile Thr Cys Lys Ala Ser Gln Ser Val Ser Asn Asp Val Thr Trp 
            180                 185                 190         


Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Ser Ala 
        195                 200                 205             


Ser Asn Arg Tyr Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Tyr 
    210                 215                 220                 


Gly Thr Glu Phe Thr Phe Thr Ile Ser Ser Val Gln Ser Glu Asp Phe 
225                 230                 235                 240 


Ala Val Tyr Phe Cys Gln Gln Asp Tyr Ser Ser Phe Gly Gln Gly Thr 
                245                 250                 255     


Lys Leu Glu Ile Lys Arg 
            260         


<210> 17
<211> 786
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 17
atgttggact ttcaagtgca gatcttcagc ttcctgctga tctccgccag cgtgatcatg       60

agcagaggcc aggtgcagct ggtggaatct ggacctggcg tggtgcagcc aggcagaagc      120

ctgagaatca gctgtgccgt gtccggcttc agcgtgacca actacggcgt gcactgggtg      180

cgccagcctc caggcaaagg actggaatgg ctgggcgtga tctgggctgg cggcatcacc      240

aactacaaca gcgccttcat gagccggctg accatcagca aggacaacag caagaacacc      300

gtgtacctgc agatgaacag cctgcgggcc gaggacaccg ccatgtacta ctgtgctagc      360

agaggcggcc actacggcta cgccctggat tattggggcc agggcacact cgtgaccgtg      420

tctagcggag gcggaggatc tggcggcgga ggaagtggcg gagggggatc tgagatcgtg      480

atgacccaga cccctgccac cctgtctgtg tctgccggcg agagagtgac cattacctgc      540

aaggccagcc agagcgtgtc caacgacgtg acctggtatc agcagaagcc cggccaggcc      600

cccagactgc tgatctacag cgccagcaac cggtacagcg gagtgcccgc cagattttcc      660

ggcagcggct acggcaccga gttcaccttc accatcagca gcgtgcagag cgaggacttc      720

gccgtgtact tctgtcagca agactacagc agcttcggcc agggcaccaa gctggaaatc      780

aagaga                                                                 786


<210> 18
<211> 22
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 18
Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val 
1               5                   10                  15      


Glu Glu Asn Pro Gly Pro 
            20          


<210> 19
<211> 66
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 19
ggatccggcg ccaccaactt cagcctgctg aaacaggccg gggatgtgga agagaaccct       60

ggccct                                                                  66


<210> 20
<211> 21
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 20
Gly Ser Gly Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu 
1               5                   10                  15      


Glu Asn Pro Gly Pro 
            20      


<210> 21
<211> 140
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 21
tgatcggctt cagaatcctg ctgctgaagg tggccggatt caacctgctg atgaccctgc       60

ggctgtggtc ctccgcgggg agcggcgagg gaagaggatc tctgctaaca tgcggtgacg      120

ttgaggagaa tcccggaccg                                                  140


<210> 22
<211> 331
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 22
Pro Pro Arg Leu Leu Phe Phe Leu Leu Phe Leu Thr Pro Met Glu Val 
1               5                   10                  15      


Arg Pro Glu Glu Pro Leu Val Val Lys Val Glu Glu Gly Asp Asn Ala 
            20                  25                  30          


Val Leu Gln Cys Leu Lys Gly Thr Ser Asp Gly Pro Thr Gln Gln Leu 
        35                  40                  45              


Thr Trp Ser Arg Glu Ser Pro Leu Lys Pro Phe Leu Lys Leu Ser Leu 
    50                  55                  60                  


Gly Leu Pro Gly Leu Gly Ile His Met Arg Pro Leu Ala Ile Trp Leu 
65                  70                  75                  80  


Phe Ile Phe Asn Val Ser Gln Gln Met Gly Gly Phe Tyr Leu Cys Gln 
                85                  90                  95      


Pro Gly Pro Pro Ser Glu Lys Ala Trp Gln Pro Gly Trp Thr Val Asn 
            100                 105                 110         


Val Glu Gly Ser Gly Glu Leu Phe Arg Trp Asn Val Ser Asp Leu Gly 
        115                 120                 125             


Gly Leu Gly Cys Gly Leu Lys Asn Arg Ser Ser Glu Gly Pro Ser Ser 
    130                 135                 140                 


Pro Ser Gly Lys Leu Met Ser Pro Lys Leu Tyr Val Trp Ala Lys Asp 
145                 150                 155                 160 


Arg Pro Glu Ile Trp Glu Gly Glu Pro Pro Cys Leu Pro Pro Arg Asp 
                165                 170                 175     


Ser Leu Asn Gln Ser Leu Ser Gln Asp Leu Thr Met Ala Pro Gly Ser 
            180                 185                 190         


Thr Leu Trp Leu Ser Cys Gly Val Pro Pro Asp Ser Val Ser Arg Gly 
        195                 200                 205             


Pro Leu Ser Trp Thr His Val His Pro Lys Gly Pro Lys Ser Leu Leu 
    210                 215                 220                 


Ser Leu Glu Leu Lys Asp Asp Arg Pro Ala Arg Asp Met Trp Val Met 
225                 230                 235                 240 


Glu Thr Gly Leu Leu Leu Pro Arg Ala Thr Ala Gln Asp Ala Gly Lys 
                245                 250                 255     


Tyr Tyr Cys His Arg Gly Asn Leu Thr Met Ser Phe His Leu Glu Ile 
            260                 265                 270         


Thr Ala Arg Pro Val Leu Trp His Trp Leu Leu Arg Thr Gly Gly Trp 
        275                 280                 285             


Lys Val Ser Ala Val Thr Leu Ala Tyr Leu Ile Phe Cys Leu Cys Ser 
    290                 295                 300                 


Leu Val Gly Ile Leu His Leu Gln Arg Ala Leu Val Leu Arg Arg Lys 
305                 310                 315                 320 


Arg Lys Arg Met Thr Asp Pro Thr Arg Arg Phe 
                325                 330     


<210> 23
<211> 996
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 23
ccccctcggc tgctgttctt cctgctgttc ctgaccccta tggaagtgcg gcccgaggaa       60

cccctggtcg tgaaagtgga agagggcgac aacgccgtgc tgcagtgtct gaagggcacc      120

tccgatggcc ctacccagca gctgacatgg tccagagaga gccccctgaa gcccttcctg      180

aagctgagcc tgggactgcc tggcctgggc atccatatga ggccactggc catctggctg      240

ttcatcttca acgtgtccca gcagatgggc ggcttctacc tgtgtcagcc tggcccccca      300

agcgagaaag cctggcagcc tggctggacc gtgaacgtgg aaggatctgg cgagctgttc      360

cggtggaacg tgtccgatct gggcggactg ggctgcggcc tgaagaacag aagcagcgag      420

ggccctagca gccccagcgg caaactgatg agccccaagc tgtacgtgtg ggccaaggac      480

cggcccgaga tttgggaagg cgagcctcct tgcctgcccc ccagagacag cctgaatcag      540

agcctgagcc aggacctgac aatggcccct ggcagcacac tgtggctgag ctgtggcgtg      600

ccacccgact ctgtgtccag aggccctctg agctggaccc acgtgcaccc taagggccct      660

aagagcctgc tgtccctgga actgaaggac gacagacccg ccagagatat gtgggtcatg      720

gaaaccggcc tgctgctgcc tagagccacc gctcaggatg ccggaaagta ctactgccac      780

cggggcaacc tgaccatgag cttccacctg gaaatcaccg ccagacccgt gctgtggcac      840

tggctgctga gaaccggcgg atggaaagtg tccgccgtga ccctggccta cctgatcttc      900

tgcctgtgct ccctcgtggg catcctgcat ctgcagcggg ctctggtgct gcggcggaag      960

agaaagagaa tgaccgaccc cacccgcaga ttctaa                                996


<210> 24
<211> 2916
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 24
atggacttcc aggttcagat cttctccttt ctcctgatat ccgcatctgt gattatgtct       60

cggggtcagg tgcagctggt tgaatctgga cctggtgtgg tacagcctgg acggagcctg      120

cgaatctcat gcgctgtctc cggtttctct gtaaccaact atggagtgca ctgggtgcgg      180

cagcctccag gcaagggcct ggaatggctc ggagttatct gggctggcgg aattacaaat      240

tataattccg cttttatgag caggttgaca attagtaaag acaattctaa gaacaccgtt      300

tatcttcaga tgaatagctt gagagctgag gataccgcca tgtactattg tgcatcaaga      360

ggcgggcact acggatacgc gctcgactac tggggacagg ggacacttgt gactgtcagt      420

tctggaggcg gtgggagcga ctataaagac gacgatgaca agggtggcgg aggaagcgag      480

atcgtaatga ctcagactcc cgctacactg agtgttagtg ccggagagcg cgttacaatc      540

acttgcaagg catcacaatc tgtttccaac gacgtcactt ggtaccagca gaagcctggg      600

caggctccta gattgctgat ttactccgct agcaatcgct actctggggt ccctgctcgc      660

tttagtggaa gtggctatgg cactgagttt accttcacca tcagcagcgt ccagtcagaa      720

gactttgccg tgtacttctg ccaacaggac tatagctcat ttggtcaggg aaccaagctt      780

gagatcaaac gcgtcgacct gaacaaggtg ttcccacccg aggtcgctgt gtttgagcca      840

tcagaagcag agatatccca cacccaaaag gccacactgg tgtgcctggc cacaggcttc      900

ttccccgacc acgtggagct gagctggtgg gtgaatggga aggaggtgca cagtggggtc      960

tgcacggacc cgcagcccct caaggagcag cccgccctca atgactccag atactgcctg     1020

agcagccgcc tgagggtctc ggccaccttc tggcagaacc cccgcaacca cttccgctgt     1080

caagtccagt tctacgggct ctcggagaat gacgagtgga cccaggatag ggccaaaccc     1140

gtcacccaga tcgtcagcgc cgaggcctgg ggtagagcag actgtggctt tacctcggtg     1200

tcctaccagc aaggggtcct gtctgccacc atcctctatg agatcctgct agggaaggcc     1260

accctgtatg ctgtgctggt cagcgccctt gtgttgatgg ctatggtcaa gagaaaggga     1320

tccggcgcca ccaacttcag cctgctgaaa caggccgggg atgtggaaga gaaccctggc     1380

ccttcgaaaa gcctgcgggt gctgctcgtg atcctgtggc tgcagctgag ctgggtgtgg     1440

agcgcatgcc ctgccgtgta ccagctgaga gacagcaaga gcagcgacaa gagcgtgtgc     1500

ctgttcaccg acttcgacag ccagaccaac gtgtcccaga gcaaggactc cgatgtgtac     1560

atcaccgata agtgcgtgct ggacatgcgg agcatggact tcaagagcaa cagcgccgtg     1620

gcctggtcca acaagagcga tttcgcctgc gccaacgcct tcaacaacag cattatcccc     1680

gaggacacat tcttcccaag ccccgagagc agctgtgatg tgaagctggt ggaaaagagc     1740

ttcgagacag acaccaacct gaacttccag aacctgagcg tgatcggctt cagaatcctg     1800

ctgctgaagg tggccggatt caacctgctg atgaccctgc ggctgtggtc ctccgcgggg     1860

agcggcgagg gaagaggatc tctgctaaca tgcggtgacg ttgaggagaa tcccggaccg     1920

ccccctcggc tgctgttctt cctgctgttc ctgaccccta tggaagtgcg gcccgaggaa     1980

cccctggtcg tgaaagtgga agagggcgac aacgccgtgc tgcagtgtct gaagggcacc     2040

tccgatggcc ctacccagca gctgacatgg tccagagaga gccccctgaa gcccttcctg     2100

aagctgagcc tgggactgcc tggcctgggc atccatatga ggccactggc catctggctg     2160

ttcatcttca acgtgtccca gcagatgggc ggcttctacc tgtgtcagcc tggcccccca     2220

agcgagaaag cctggcagcc tggctggacc gtgaacgtgg aaggatctgg cgagctgttc     2280

cggtggaacg tgtccgatct gggcggactg ggctgcggcc tgaagaacag aagcagcgag     2340

ggccctagca gccccagcgg caaactgatg agccccaagc tgtacgtgtg ggccaaggac     2400

cggcccgaga tttgggaagg cgagcctcct tgcctgcccc ccagagacag cctgaatcag     2460

agcctgagcc aggacctgac aatggcccct ggcagcacac tgtggctgag ctgtggcgtg     2520

ccacccgact ctgtgtccag aggccctctg agctggaccc acgtgcaccc taagggccct     2580

aagagcctgc tgtccctgga actgaaggac gacagacccg ccagagatat gtgggtcatg     2640

gaaaccggcc tgctgctgcc tagagccacc gctcaggatg ccggaaagta ctactgccac     2700

cggggcaacc tgaccatgag cttccacctg gaaatcaccg ccagacccgt gctgtggcac     2760

tggctgctga gaaccggcgg atggaaagtg tccgccgtga ccctggccta cctgatcttc     2820

tgcctgtgct ccctcgtggg catcctgcat ctgcagcggg ctctggtgct gcggcggaag     2880

agaaagagaa tgaccgaccc cacccgcaga ttctaa                               2916


<210> 25
<211> 448
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 25
Met Leu Asp Phe Gln Val Gln Ile Phe Ser Phe Leu Leu Ile Ser Ala 
1               5                   10                  15      


Ser Val Ile Met Ser Arg Gly Gln Val Gln Leu Val Glu Ser Gly Pro 
            20                  25                  30          


Gly Val Val Gln Pro Gly Arg Ser Leu Arg Ile Ser Cys Ala Val Ser 
        35                  40                  45              


Gly Phe Ser Val Thr Asn Tyr Gly Val His Trp Val Arg Gln Pro Pro 
    50                  55                  60                  


Gly Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Ala Gly Gly Ile Thr 
65                  70                  75                  80  


Asn Tyr Asn Ser Ala Phe Met Ser Arg Leu Thr Ile Ser Lys Asp Asn 
                85                  90                  95      


Ser Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
            100                 105                 110         


Thr Ala Met Tyr Tyr Cys Ala Ser Arg Gly Gly His Tyr Gly Tyr Ala 
        115                 120                 125             


Leu Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Val 
145                 150                 155                 160 


Met Thr Gln Thr Pro Ala Thr Leu Ser Val Ser Ala Gly Glu Arg Val 
                165                 170                 175     


Thr Ile Thr Cys Lys Ala Ser Gln Ser Val Ser Asn Asp Val Thr Trp 
            180                 185                 190         


Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Ser Ala 
        195                 200                 205             


Ser Asn Arg Tyr Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Tyr 
    210                 215                 220                 


Gly Thr Glu Phe Thr Phe Thr Ile Ser Ser Val Gln Ser Glu Asp Phe 
225                 230                 235                 240 


Ala Val Tyr Phe Cys Gln Gln Asp Tyr Ser Ser Phe Gly Gln Gly Thr 
                245                 250                 255     


Lys Leu Glu Ile Lys Arg Ser Gly Gly Gly Ser Gly Tyr Pro Tyr Asp 
            260                 265                 270         


Val Pro Asp Tyr Ala Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu 
        275                 280                 285             


Val Ala Gln Asn Val Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser 
    290                 295                 300                 


Asp Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys 
305                 310                 315                 320 


Glu Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val 
                325                 330                 335     


Phe Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly 
            340                 345                 350         


Ser Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly 
        355                 360                 365             


Ala Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu 
    370                 375                 380                 


Ala Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser 
385                 390                 395                 400 


Ala Gly Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg 
                405                 410                 415     


His Ala Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg 
            420                 425                 430         


Val Thr Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Asp His 
        435                 440                 445             


<210> 26
<211> 1582
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 26
ggcctaactg gccggcacct gagccagatg acggtggaaa aattgcatca tacagaaggc       60

ttggaggaaa aactgtttca atcactacgc tcggaggaaa atttgtatca ttgagatggc      120

ctcggcggcc agaagccggc tgtagagggt atataatgga agctcgaatt ccagcctggc      180

cttccggtac tgttggtaga aggcctggca gagcggcacc gtgggaaagg ccaccatgtt      240

ggactttcaa gtgcagatct tcagcttcct gctgatctcc gccagcgtga tcatgagcag      300

aggccaggtg cagctggtgg aatctggacc tggcgtggtg cagccaggca gaagcctgag      360

aatcagctgt gccgtgtccg gcttcagcgt gaccaactac ggcgtgcact gggtgcgcca      420

gcctccaggc aaaggactgg aatggctggg cgtgatctgg gctggcggca tcaccaacta      480

caacagcgcc ttcatgagcc ggctgaccat cagcaaggac aacagcaaga acaccgtgta      540

cctgcagatg aacagcctgc gggccgagga caccgccatg tactactgtg ctagcagagg      600

cggccactac ggctacgccc tggattattg gggccagggc acactcgtga ccgtgtctag      660

cggaggcgga ggatctggcg gcggaggaag tggcggaggg ggatctgaga tcgtgatgac      720

ccagacccct gccaccctgt ctgtgtctgc cggcgagaga gtgaccatta cctgcaaggc      780

cagccagagc gtgtccaacg acgtgacctg gtatcagcag aagcccggcc aggcccccag      840

actgctgatc tacagcgcca gcaaccggta cagcggagtg cccgccagat tttccggcag      900

cggctacggc accgagttca ccttcaccat cagcagcgtg cagagcgagg acttcgccgt      960

gtacttctgt cagcaagact acagcagctt cggccagggc accaagctgg aaatcaagag     1020

atccggcgga ggctccggct acccctacga cgtgcccgac tatgcattgg acctgcggca     1080

gggcatgttc gcccagctgg tggctcagaa cgtgctgctg atcgacggcc ccctgagctg     1140

gtactctgat cctggactgg ctggcgtgtc cctgaccggc ggactgagct acaaagagga     1200

cacaaaagaa ctggtggtgg ccaaggccgg cgtgtactac gtgttctttc agctggaact     1260

gcggagagtg gtggccggcg agggatctgg atctgtgtct ctggccctgc atctgcagcc     1320

cctgagatct gctgctggcg cagctgctct ggctctgacc gtggatctgc ctcctgccag     1380

cagcgaggcc agaaacagcg cattcgggtt tcaaggcagg ctgctgcacc tgagcgccgg     1440

acagagactg ggagtgcatc tgcacacaga ggccagagcc aggcacgcct ggcagctgac     1500

acagggcgct acagtgctgg gcctgttcag agtgaccccc gagattcctg ccggcctgcc     1560

tagccctaga agcgaccact aa                                              1582


<210> 27
<211> 988
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 27
gtcgacctga acaaggtgtt cccacccgag gtcgctgtgt ttgagccatc agaagcagag       60

atatcccaca cccaaaaggc cacactggtg tgcctggcca caggcttctt ccccgaccac      120

gtggagctga gctggtgggt gaatgggaag gaggtgcaca gtggggtctg cacggacccg      180

cagcccctca aggagcagcc cgccctcaat gactccagat actgcctgag cagccgcctg      240

agggtctcgg ccaccttctg gcagaacccc cgcaaccact tccgctgtca agtccagttc      300

tacgggctct cggagaatga cgagtggacc caggataggg ccaaacccgt cacccagatc      360

gtcagcgccg aggcctgggg tagagcagac tgtggcttta cctcggtgtc ctaccagcaa      420

ggggtcctgt ctgccaccat cctctatgag atcctgctag ggaaggccac cctgtatgct      480

gtgctggtca gcgcccttgt gttgatggct atggtcaaga gaaagggatc cggcgccacc      540

aacttcagcc tgctgaaaca ggccggggat gtggaagaga accctggccc ttcgaaaagc      600

ctgcgggtgc tgctcgtgat cctgtggctg cagctgagct gggtgtggag cgcatgccct      660

gccgtgtacc agctgagaga cagcaagagc agcgacaaga gcgtgtgcct gttcaccgac      720

ttcgacagcc agaccaacgt gtcccagagc aaggactccg atgtgtacat caccgataag      780

tgcgtgctgg acatgcggag catggacttc aagagcaaca gcgccgtggc ctggtccaac      840

aagagcgatt tcgcctgcgc caacgccttc aacaacagca ttatccccga ggacacattc      900

ttcccaagcc ccgagagcag ctgtgatgtg aagctggtgg aaaagagctt cgagacagac      960

accaacctga acttccagaa cctgagcg                                         988


<210> 28
<211> 315
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 28
Leu Val Arg Arg Gly Ala Arg Ala Gly Pro Arg Met Pro Arg Gly Trp 
1               5                   10                  15      


Thr Ala Leu Cys Leu Leu Ser Leu Leu Pro Ser Gly Phe Met Ser Leu 
            20                  25                  30          


Asp Asn Asn Gly Thr Ala Thr Pro Glu Leu Pro Thr Gln Gly Thr Phe 
        35                  40                  45              


Ser Asn Val Ser Thr Asn Val Ser Tyr Gln Glu Thr Thr Thr Pro Ser 
    50                  55                  60                  


Thr Leu Gly Ser Thr Ser Leu His Pro Val Ser Gln His Gly Asn Glu 
65                  70                  75                  80  


Ala Thr Thr Asn Ile Thr Glu Thr Thr Val Lys Phe Thr Ser Thr Ser 
                85                  90                  95      


Val Ile Thr Ser Val Tyr Gly Asn Thr Asn Ser Ser Val Gln Ser Gln 
            100                 105                 110         


Thr Ser Val Ile Ser Thr Val Phe Thr Thr Pro Ala Asn Val Ser Thr 
        115                 120                 125             


Pro Glu Thr Thr Leu Lys Pro Ser Leu Ser Pro Gly Asn Val Ser Asp 
    130                 135                 140                 


Leu Ser Thr Thr Ser Thr Ser Leu Ala Thr Ser Pro Thr Lys Pro Tyr 
145                 150                 155                 160 


Thr Ser Ser Ser Pro Ile Leu Ser Asp Ile Lys Ala Glu Ile Lys Cys 
                165                 170                 175     


Ser Gly Ile Arg Glu Val Lys Leu Thr Gln Gly Ile Cys Leu Glu Gln 
            180                 185                 190         


Asn Lys Thr Ser Ser Cys Ala Glu Phe Lys Lys Asp Arg Gly Glu Gly 
        195                 200                 205             


Leu Ala Arg Val Leu Cys Gly Glu Glu Gln Ala Asp Ala Asp Ala Gly 
    210                 215                 220                 


Ala Gln Val Cys Ser Leu Leu Leu Ala Gln Ser Glu Val Arg Pro Gln 
225                 230                 235                 240 


Cys Leu Leu Leu Val Leu Ala Asn Arg Thr Glu Ile Ser Ser Lys Leu 
                245                 250                 255     


Gln Leu Met Lys Lys His Gln Ser Asp Leu Lys Lys Leu Gly Ile Leu 
            260                 265                 270         


Asp Phe Thr Glu Gln Asp Val Ala Ser His Gln Ser Tyr Ser Gln Lys 
        275                 280                 285             


Thr Leu Ile Ala Leu Val Thr Ser Gly Ala Leu Leu Ala Val Leu Gly 
    290                 295                 300                 


Ile Thr Gly Tyr Phe Leu Met Asn Arg Arg Phe 
305                 310                 315 


<210> 29
<211> 948
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 29
ctcgttagaa gaggcgctag agctggcccc agaatgccta gaggatggac agctctgtgc       60

ctgctgagcc tgctgcctag cggctttatg agcctggaca acaacggcac cgccacacct      120

gaactgccta cacagggcac cttcagcaat gtgtctacca acgtgtccta ccaagagaca      180

accacaccta gcacactggg cagcacatct ctgcaccctg tgtctcagca cggcaatgag      240

gccaccacca acatcaccga gacaaccgtg aagttcacct ctacctccgt gattaccagc      300

gtgtacggca acaccaacag cagcgtgcag agccagacaa gcgtgatcag caccgtgttc      360

acaacccctg ccaatgtgtc cacaccagaa accacactga agcccagcct gtctcctgga      420

aacgtgtccg atctgagcac cacctctaca agcctggcca cctctcctac aaagccctac      480

acaagcagca gccccatcct gagcgatatc aaggccgaga tcaagtgcag cggcatccgg      540

gaagtgaagc tgacccaggg catctgcctg gaacagaaca agaccagcag ctgcgccgag      600

ttcaagaagg acagaggcga aggactggcc agagtgctgt gtggcgaaga acaggccgat      660

gctgatgctg gcgctcaagt gtgctctctg ctgctggctc agtctgaagt gcggcctcag      720

tgtctgttgc tggtgctggc caacagaacc gagatcagca gcaaactgca gctgatgaag      780

aagcaccaga gcgacctgaa gaagctgggc atcctggact tcaccgagca ggatgtggcc      840

tctcaccaga gctacagcca gaaaaccctg atcgccctgg tcacatctgg cgctctgctg      900

gctgtgctgg gaatcaccgg ctactttctg atgaatcgga gattctaa                   948


<210> 30
<211> 265
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 30
Met Val Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Asp Ile Gln Met Thr Gln Thr Thr Ser Ser 
            20                  25                  30          


Leu Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser 
        35                  40                  45              


Gln Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly 
    50                  55                  60                  


Thr Val Lys Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly Val 
65                  70                  75                  80  


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr 
                85                  90                  95      


Ile Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln 
            100                 105                 110         


Gly Asn Thr Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile 
        115                 120                 125             


Gly Gly Gly Gly Ser Asp Tyr Lys Asp Asp Asp Asp Lys Gly Gly Gly 
    130                 135                 140                 


Gly Ser Glu Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro 
145                 150                 155                 160 


Ser Gln Ser Leu Ser Val Thr Cys Thr Val Ser Gly Val Ser Leu Pro 
                165                 170                 175     


Asp Tyr Gly Val Ser Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu Glu 
            180                 185                 190         


Trp Leu Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala 
        195                 200                 205             


Leu Lys Ser Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln Val 
    210                 215                 220                 


Phe Leu Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr 
225                 230                 235                 240 


Cys Ala Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp 
                245                 250                 255     


Gly Gln Gly Thr Ser Val Thr Val Ser 
            260                 265 


<210> 31
<211> 795
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 31
atggttctgc tcgtgacctc tctgctgctg tgcgagctgc cccaccctgc ctttctgctg       60

atccccgaca tccagatgac ccagaccacc agcagcctga gcgccagcct gggcgataga      120

gtgaccatca gctgcagagc cagccaggac atcagcaagt acctgaactg gtatcagcag      180

aaacccgacg gcaccgtgaa gctgctgatc taccacacca gcagactgca cagcggcgtg      240

cccagcagat tttctggcag cggctccggc accgactaca gcctgaccat ctccaacctg      300

gaacaggaag atattgctac ctacttctgt cagcaaggca acaccctgcc ctacaccttc      360

ggcggaggca ccaagctgga aatcggaggc ggcggaagcg actacaagga cgacgacgat      420

aagggcggag ggggcagcga agtgaaactg caggaatctg gccctggcct ggtggcccca      480

agccagtctc tgagcgtgac ctgtaccgtg tccggcgtgt ccctgcctga ctatggcgtg      540

tcctggatca gacagccccc cagaaagggc ctggaatggc tgggagtgat ctggggctcc      600

gagacaacct actacaacag cgccctgaag tcccggctga ccatcatcaa ggacaactcc      660

aagagccagg tgttcctgaa gatgaacagc ctgcagaccg acgacaccgc catctactac      720

tgcgccaagc actactacta cggcggcagc tacgctatgg actactgggg ccagggaacc      780

agcgtgaccg tgtct                                                       795


<210> 32
<211> 217
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 32
Glu His Ser Thr Phe Leu Ser Gly Leu Val Leu Ala Thr Leu Leu Ser 
1               5                   10                  15      


Gln Val Ser Pro Phe Lys Ile Pro Ile Glu Glu Leu Glu Asp Arg Val 
            20                  25                  30          


Phe Val Asn Cys Asn Thr Ser Ile Thr Trp Val Glu Gly Thr Val Gly 
        35                  40                  45              


Thr Leu Leu Ser Asp Ile Thr Arg Leu Asp Leu Gly Lys Arg Ile Leu 
    50                  55                  60                  


Asp Pro Arg Gly Ile Tyr Arg Cys Asn Gly Thr Asp Ile Tyr Lys Asp 
65                  70                  75                  80  


Lys Glu Ser Thr Val Gln Val His Tyr Arg Met Cys Gln Ser Cys Val 
                85                  90                  95      


Glu Leu Asp Pro Ala Thr Val Ala Gly Ile Ile Val Thr Asp Val Ile 
            100                 105                 110         


Ala Thr Leu Leu Leu Ala Leu Gly Val Phe Cys Phe Ala Gly His Glu 
        115                 120                 125             


Thr Gly Arg Leu Ser Gly Ala Ala Asp Thr Gln Ala Leu Leu Arg Asn 
    130                 135                 140                 


Asp Gln Val Tyr Gln Pro Leu Arg Asp Arg Asp Asp Ala Gln Tyr Ser 
145                 150                 155                 160 


His Leu Gly Gly Asn Trp Ala Arg Asn Lys Ser Gly Gly Gly Ser Lys 
                165                 170                 175     


Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg 
            180                 185                 190         


Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro 
        195                 200                 205             


Glu Glu Glu Glu Gly Gly Cys Glu Leu 
    210                 215         


<210> 33
<211> 651
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 33
gagcacagca cctttctgag cggactggtg ctggccaccc tgctgtctca ggtgtccccc       60

ttcaaaatcc ccatcgagga actggaagat cgggtgttcg tgaactgcaa caccagcatt      120

acctgggtgg aaggcaccgt gggcacactg ctgagcgaca tcaccagact ggacctgggc      180

aagagaatcc tggaccccag aggcatctac cggtgcaacg gcaccgacat ctacaaggac      240

aaagaaagca ccgtgcaggt gcactaccgg atgtgccaga gctgcgtgga actggaccct      300

gccacagtgg ccggcatcat cgtgaccgat gtgatcgcca ctctgctgct ggccctgggc      360

gtgttctgtt tcgccggaca cgagacaggc agactgagcg gagccgccga tacacaggcc      420

ctgctgagaa acgaccaggt gtaccagccc ctgcgggaca gagatgacgc ccagtattct      480

cacctgggcg gcaactgggc ccggaacaaa tctggcggcg gaagcaagcg gggcagaaag      540

aagctgctgt acatcttcaa gcagcccttc atgcggcccg tgcagaccac ccaggaagag      600

gacggctgct cctgcagatt ccccgaggaa gaagaaggcg gctgcgagct g               651


<210> 34
<211> 248
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 34
Val Asp Leu Asn Lys Val Phe Pro Pro Glu Val Ala Val Phe Glu Pro 
1               5                   10                  15      


Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr Leu Val Cys Leu 
            20                  25                  30          


Ala Thr Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp Trp Val Asn 
        35                  40                  45              


Gly Lys Glu Val His Ser Gly Val Cys Thr Asp Pro Gln Pro Leu Lys 
    50                  55                  60                  


Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu Ser Ser Arg Leu 
65                  70                  75                  80  


Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn His Phe Arg Cys 
                85                  90                  95      


Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu Trp Thr Gln Asp 
            100                 105                 110         


Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu Ala Trp Gly Arg 
        115                 120                 125             


Ala Asp Cys Gly Phe Thr Ser Val Ser Tyr Gln Gln Gly Val Leu Ser 
    130                 135                 140                 


Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala 
145                 150                 155                 160 


Val Leu Val Ser Ala Leu Val Leu Met Ala Met Val Lys Arg Lys Gly 
                165                 170                 175     


Gly Asn Lys Glu Lys Lys Ala Val Ser Pro Leu Leu Leu Thr Thr Thr 
            180                 185                 190         


Asn Ser Ser Glu Gly Leu Ser Met Gly Asn Tyr Ile Gly Ser Lys Arg 
        195                 200                 205             


Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro 
    210                 215                 220                 


Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu 
225                 230                 235                 240 


Glu Glu Glu Gly Gly Cys Glu Leu 
                245             


<210> 35
<211> 744
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 35
gtcgacctga acaaggtgtt ccccccagag gtggccgtgt tcgagccttc tgaggccgag       60

atcagccaca cccagaaagc taccctcgtg tgcctggcca ccggcttttt ccccgaccac      120

gtggaactgt cttggtgggt caacggcaaa gaggtgcact ccggcgtgtg caccgatccc      180

cagcctctga aagaacagcc cgccctgaac gacagccggt actgcctgag cagcagactg      240

agagtgtccg ccaccttctg gcagaacccc cggaaccact tcagatgcca ggtgcagttc      300

tacggcctga gcgagaacga cgagtggacc caggacagag ccaagcccgt gacccagatc      360

gtgtctgccg aagcctgggg cagagccgac tgtggcttta ccagcgtgtc ctatcagcag      420

ggcgtgctga gcgccaccat cctgtacgag atcctgctgg gcaaggccac cctgtacgcc      480

gtgctggtgt ctgccctggt gctgatggct atggtcaagc ggaagggcgg caacaaagaa      540

aagaaagccg tgtcccccct gctgctgacc accaccaata gcagcgaggg cctgagcatg      600

ggcaactaca tcggcagcaa gcggggcaga aagaagctgc tgtacatctt caagcagccc      660

ttcatgcggc ccgtgcagac cacccaggaa gaggacggct gctcctgcag attccccgag      720

gaagaagaag gcggctgcga gctg                                             744


<210> 36
<211> 231
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 36
Ser Lys Ser Leu Arg Val Leu Leu Val Ile Leu Trp Leu Gln Leu Ser 
1               5                   10                  15      


Trp Val Trp Ser Ala Cys Pro Ala Val Tyr Gln Leu Arg Asp Ser Lys 
            20                  25                  30          


Ser Ser Asp Lys Ser Val Cys Leu Phe Thr Asp Phe Asp Ser Gln Thr 
        35                  40                  45              


Asn Val Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile Thr Asp Lys Cys 
    50                  55                  60                  


Val Leu Asp Met Arg Ser Met Asp Phe Lys Ser Asn Ser Ala Val Ala 
65                  70                  75                  80  


Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala Phe Asn Asn Ser 
                85                  90                  95      


Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro Glu Ser Ser Cys Asp 
            100                 105                 110         


Val Lys Leu Val Glu Lys Ser Phe Glu Thr Asp Thr Asn Leu Asn Phe 
        115                 120                 125             


Gln Asn Leu Ser Val Ile Gly Phe Arg Ile Leu Leu Leu Lys Val Ala 
    130                 135                 140                 


Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser Ala Gly Gly 
145                 150                 155                 160 


Asn Lys Glu Lys Lys Ala Val Ser Pro Leu Leu Leu Thr Thr Thr Asn 
                165                 170                 175     


Ser Ser Glu Gly Leu Ser Met Gly Asn Tyr Ile Gly Ser Lys Arg Gly 
            180                 185                 190         


Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val 
        195                 200                 205             


Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu 
    210                 215                 220                 


Glu Glu Gly Gly Cys Glu Leu 
225                 230     


<210> 37
<211> 693
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 37
tcgaaaagcc tgcgggtgct gctcgtgatc ctgtggctgc agctgagctg ggtgtggagc       60

gcatgccctg ccgtgtacca gctgagagac agcaagagca gcgacaagag cgtgtgcctg      120

ttcaccgact tcgacagcca gaccaacgtg tcccagagca aggacagcga cgtgtacatc      180

accgataagt gcgtgctgga catgcggagc atggacttca agagcaacag cgccgtggcc      240

tggtccaaca agagcgattt cgcctgcgcc aacgccttca acaacagcat tatccccgag      300

gacacattct tcccaagccc cgagagcagc tgcgacgtga agctggtgga aaagagcttc      360

gagacagaca ccaacctgaa cttccagaac ctgagcgtga tcggcttcag aatcctgctg      420

ctgaaggtgg ccggcttcaa cctgctgatg accctgagac tgtggtcctc cgctggcggc      480

aacaaagaaa agaaagccgt gtcccctctg ctgctgacca ccaccaatag cagcgagggc      540

ctgagcatgg gcaactacat cggcagcaag cggggcagaa agaagctgct gtacatcttc      600

aagcagccct tcatgcggcc cgtgcagacc acccaggaag aggacggctg ctcctgccgg      660

ttccccgaag aggaagaagg gggctgcgaa ctg                                   693


<210> 38
<211> 353
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 38
Gly Asn Ser Cys Tyr Asn Ile Val Ala Thr Leu Leu Leu Val Leu Asn 
1               5                   10                  15      


Thr Ser Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Ala Cys Gly Cys Ala 
            20                  25                  30          


Ala Ala Pro Asp Val Lys Glu Leu Leu Ser Arg Leu Glu Glu Leu Glu 
        35                  40                  45              


Asn Leu Val Ser Ser Leu Arg Glu Gln Cys Thr Ser Gly Gly Gly Gly 
    50                  55                  60                  


Ser Ile Ile Ser Phe Phe Leu Ala Leu Thr Ser Thr Ala Leu Leu Phe 
65                  70                  75                  80  


Leu Leu Phe Phe Leu Thr Leu Arg Phe Ser Val Val Lys Arg Gly Arg 
                85                  90                  95      


Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln 
            100                 105                 110         


Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu 
        115                 120                 125             


Glu Gly Gly Cys Glu Leu Glu Gln Ile Ala Glu Phe Lys Glu Ala Phe 
    130                 135                 140                 


Ser Leu Phe Asp Lys Asp Gly Asp Gly Thr Ile Thr Thr Lys Glu Leu 
145                 150                 155                 160 


Gly Thr Val Met Arg Ser Leu Gly Gln Asn Pro Thr Glu Ala Glu Leu 
                165                 170                 175     


Gln Asp Met Ile Asn Glu Val Asp Ala Asp Gly Asn Gly Thr Ile Asp 
            180                 185                 190         


Phe Pro Glu Phe Leu Thr Met Met Ala Arg Lys Met Lys Asp Thr Gly 
        195                 200                 205             


Gly Val Arg Leu Ile Pro Ser Trp Thr Thr Val Ile Leu Val Lys Ser 
    210                 215                 220                 


Met Leu Arg Lys Arg Ser Phe Gly Asn Pro Phe Gly Gly Asp Ser Glu 
225                 230                 235                 240 


Glu Glu Ile Arg Glu Ala Phe Arg Val Phe Asp Lys Asp Gly Asn Gly 
                245                 250                 255     


Tyr Ile Ser Ala Ala Glu Leu Arg His Val Met Thr Asn Leu Gly Glu 
            260                 265                 270         


Lys Leu Thr Asp Glu Glu Val Asp Glu Met Ile Arg Glu Ala Asp Ile 
        275                 280                 285             


Asp Gly Asp Gly Gln Val Asn Tyr Glu Glu Phe Val Gln Met Met Thr 
    290                 295                 300                 


Ala Lys Ser Gly Gly Gly Ser Lys Arg Gly Arg Lys Lys Leu Leu Tyr 
305                 310                 315                 320 


Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu 
                325                 330                 335     


Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu 
            340                 345                 350         


Leu 
    


<210> 39
<211> 1059
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 39
gggaactctt gctacaacat cgttgcaact cttctcttgg tcctcaatac tagttatcca       60

tacgacgtcc cggactatgc cgcttgtggc tgcgccgccg cccccgatgt caaggaactg      120

ctcagcaggt tggaagagct tgaaaatctg gtttcctccc ttcgagaaca gtgtactagt      180

ggcggtggcg gatctataat ctctttcttt ctcgctctca ctagcaccgc gttgcttttt      240

cttttgtttt tcttgacgtt gaggttctca gttgttaagc gaggccggaa aaaactgctt      300

tacattttca aacaaccctt tatgcgacca gttcaaacga cgcaggagga ggatggttgt      360

tcctgtcggt ttccagaaga ggaggaaggg ggctgtgagc ttgagcagat tgcggaattt      420

aaggaagcat tcagtctgtt tgacaaagat ggcgacggca caattacaac gaaagaactt      480

ggcacagtaa tgcggtcact gggtcagaat ccgacagagg ccgaactcca ggacatgata      540

aatgaagttg acgctgacgg taacggaacc attgattttc ctgaatttct taccatgatg      600

gcccgaaaaa tgaaagatac cggtggtgtc agacttatac ccagttggac gacggtaatt      660

cttgtaaaat ctatgctgcg gaagcgcagt ttcggcaacc catttggcgg ggactctgag      720

gaagagatcc gagaagcgtt ccgagtgttc gataaggacg gaaacggcta catttccgca      780

gctgaactgc gacatgtgat gaccaacctt ggggaaaagt tgactgatga agaagttgac      840

gaaatgatcc gggaggctga tatagacggg gatggacaag taaactacga ggagttcgtt      900

cagatgatga ccgcaaagtc agggggtggt tctaaacgcg gccgcaaaaa attgctttat      960

atctttaaac aacccttcat gaggcctgtc cagactacac aggaggaaga cggctgtagt     1020

tgtagatttc ctgaggaaga agaaggaggg tgcgaactc                            1059


<210> 40
<211> 988
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 40
gtcgacctga acaaggtgtt cccacccgag gtcgctgtgt ttgagccatc agaagcagag       60

atatcccaca cccaaaaggc cacactggtg tgcctggcca caggcttctt ccccgaccac      120

gtggagctga gctggtgggt gaatgggaag gaggtgcaca gtggggtctg cacggacccg      180

cagcccctca aggagcagcc cgccctcaat gactccagat actgcctgag cagccgcctg      240

agggtctcgg ccaccttctg gcagaacccc cgcaaccact tccgctgtca agtccagttc      300

tacgggctct cggagaatga cgagtggacc caggataggg ccaaacccgt cacccagatc      360

gtcagcgccg aggcctgggg tagagcagac tgtggcttta cctcggtgtc ctaccagcaa      420

ggggtcctgt ctgccaccat cctctatgag atcctgctag ggaaggccac cctgtatgct      480

gtgctggtca gcgcccttgt gttgatggct atggtcaaga gaaagggatc cggcgccacc      540

aacttcagcc tgctgaaaca ggccggggat gtggaagaga accctggccc ttcgaaaagc      600

ctgcgggtgc tgctcgtgat cctgtggctg cagctgagct gggtgtggag cgcatgccct      660

gccgtgtacc agctgagaga cagcaagagc agcgacaaga gcgtgtgcct gttcaccgac      720

ttcgacagcc agaccaacgt gtcccagagc aaggactccg atgtgtacat caccgataag      780

tgcgtgctgg acatgcggag catggacttc aagagcaaca gcgccgtggc ctggtccaac      840

aagagcgatt tcgcctgcgc caacgccttc aacaacagca ttatccccga ggacacattc      900

ttcccaagcc ccgagagcag ctgtgatgtg aagctggtgg aaaagagctt cgagacagac      960

accaacctga acttccagaa cctgagcg                                         988


<210> 41
<211> 4527
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 41
atggacttcc aggttcagat cttctccttt ctcctgatat ccgcatctgt gattatgtct       60

cggggtcagg tgcagctggt tgaatctgga cctggtgtgg tacagcctgg acggagcctg      120

cgaatctcat gcgctgtctc cggtttctct gtaaccaact atggagtgca ctgggtgcgg      180

cagcctccag gcaagggcct ggaatggctc ggagttatct gggctggcgg aattacaaat      240

tataattccg cttttatgag caggttgaca attagtaaag acaattctaa gaacaccgtt      300

tatcttcaga tgaatagctt gagagctgag gataccgcca tgtactattg tgcatcaaga      360

ggcgggcact acggatacgc gctcgactac tggggacagg ggacacttgt gactgtcagt      420

tctggaggcg gtgggagcga ctataaagac gacgatgaca agggtggcgg aggaagcgag      480

atcgtaatga ctcagactcc cgctacactg agtgttagtg ccggagagcg cgttacaatc      540

acttgcaagg catcacaatc tgtttccaac gacgtcactt ggtaccagca gaagcctggg      600

caggctccta gattgctgat ttactccgct agcaatcgct actctggggt ccctgctcgc      660

tttagtggaa gtggctatgg cactgagttt accttcacca tcagcagcgt ccagtcagaa      720

gactttgccg tgtacttctg ccaacaggac tatagctcat ttggtcaggg aaccaagctt      780

gagatcaaac gcgtcgacct gaacaaggtg ttcccacccg aggtcgctgt gtttgagcca      840

tcagaagcag agatatccca cacccaaaag gccacactgg tgtgcctggc cacaggcttc      900

ttccccgacc acgtggagct gagctggtgg gtgaatggga aggaggtgca cagtggggtc      960

tgcacggacc cgcagcccct caaggagcag cccgccctca atgactccag atactgcctg     1020

agcagccgcc tgagggtctc ggccaccttc tggcagaacc cccgcaacca cttccgctgt     1080

caagtccagt tctacgggct ctcggagaat gacgagtgga cccaggatag ggccaaaccc     1140

gtcacccaga tcgtcagcgc cgaggcctgg ggtagagcag actgtggctt tacctcggtg     1200

tcctaccagc aaggggtcct gtctgccacc atcctctatg agatcctgct agggaaggcc     1260

accctgtatg ctgtgctggt cagcgccctt gtgttgatgg ctatggtcaa gagaaaggga     1320

tccggcgcca ccaacttcag cctgctgaaa caggccgggg atgtggaaga gaaccctggc     1380

ccttcgaaaa gcctgcgggt gctgctcgtg atcctgtggc tgcagctgag ctgggtgtgg     1440

agcgcatgcc ctgccgtgta ccagctgaga gacagcaaga gcagcgacaa gagcgtgtgc     1500

ctgttcaccg acttcgacag ccagaccaac gtgtcccaga gcaaggactc cgatgtgtac     1560

atcaccgata agtgcgtgct ggacatgcgg agcatggact tcaagagcaa cagcgccgtg     1620

gcctggtcca acaagagcga tttcgcctgc gccaacgcct tcaacaacag cattatcccc     1680

gaggacacat tcttcccaag ccccgagagc agctgtgatg tgaagctggt ggaaaagagc     1740

ttcgagacag acaccaacct gaacttccag aacctgagcg tgatcggctt cagaatcctg     1800

ctgctgaagg tggccggatt caacctgctg atgaccctgc ggctgtggtc ctccgcgggg     1860

agcggcgagg gaagaggatc tctgctaaca tgcggtgacg ttgaggagaa tcccggaccg     1920

ccccctcggc tgctgttctt cctgctgttc ctgaccccta tggaagtgcg gcccgaggaa     1980

cccctggtcg tgaaagtgga agagggcgac aacgccgtgc tgcagtgtct gaagggcacc     2040

tccgatggcc ctacccagca gctgacatgg tccagagaga gccccctgaa gcccttcctg     2100

aagctgagcc tgggactgcc tggcctgggc atccatatga ggccactggc catctggctg     2160

ttcatcttca acgtgtccca gcagatgggc ggcttctacc tgtgtcagcc tggcccccca     2220

agcgagaaag cctggcagcc tggctggacc gtgaacgtgg aaggatctgg cgagctgttc     2280

cggtggaacg tgtccgatct gggcggactg ggctgcggcc tgaagaacag aagcagcgag     2340

ggccctagca gccccagcgg caaactgatg agccccaagc tgtacgtgtg ggccaaggac     2400

cggcccgaga tttgggaagg cgagcctcct tgcctgcccc ccagagacag cctgaatcag     2460

agcctgagcc aggacctgac aatggcccct ggcagcacac tgtggctgag ctgtggcgtg     2520

ccacccgact ctgtgtccag aggccctctg agctggaccc acgtgcaccc taagggccct     2580

aagagcctgc tgtccctgga actgaaggac gacagacccg ccagagatat gtgggtcatg     2640

gaaaccggcc tgctgctgcc tagagccacc gctcaggatg ccggaaagta ctactgccac     2700

cggggcaacc tgaccatgag cttccacctg gaaatcaccg ccagacccgt gctgtggcac     2760

tggctgctga gaaccggcgg atggaaagtg tccgccgtga ccctggccta cctgatcttc     2820

tgcctgtgct ccctcgtggg catcctgcat ctgcagcggg ctctggtgct gcggcggaag     2880

agaaagagaa tgaccgaccc cacccgcaga ttctaatcac gcgtacgtat acacaattgc     2940

atttctctgg cctaactggc cggcacctga gccagatgac ggtggaaaaa ttgcatcata     3000

cagaaggctt ggaggaaaaa ctgtttcaat cactacgctc ggaggaaaat ttgtatcatt     3060

gagatggcct cggcggccag aagccggctg tagagggtat ataatggaag ctcgaattcc     3120

agcctggcct tccggtactg ttggtagaag gcctggcaga gcggcaccgt gggaaaggcc     3180

accatgttgg actttcaagt gcagatcttc agcttcctgc tgatctccgc cagcgtgatc     3240

atgagcagag gccaggtgca gctggtggaa tctggacctg gcgtggtgca gccaggcaga     3300

agcctgagaa tcagctgtgc cgtgtccggc ttcagcgtga ccaactacgg cgtgcactgg     3360

gtgcgccagc ctccaggcaa aggactggaa tggctgggcg tgatctgggc tggcggcatc     3420

accaactaca acagcgcctt catgagccgg ctgaccatca gcaaggacaa cagcaagaac     3480

accgtgtacc tgcagatgaa cagcctgcgg gccgaggaca ccgccatgta ctactgtgct     3540

agcagaggcg gccactacgg ctacgccctg gattattggg gccagggcac actcgtgacc     3600

gtgtctagcg gaggcggagg atctggcggc ggaggaagtg gcggaggggg atctgagatc     3660

gtgatgaccc agacccctgc caccctgtct gtgtctgccg gcgagagagt gaccattacc     3720

tgcaaggcca gccagagcgt gtccaacgac gtgacctggt atcagcagaa gcccggccag     3780

gcccccagac tgctgatcta cagcgccagc aaccggtaca gcggagtgcc cgccagattt     3840

tccggcagcg gctacggcac cgagttcacc ttcaccatca gcagcgtgca gagcgaggac     3900

ttcgccgtgt acttctgtca gcaagactac agcagcttcg gccagggcac caagctggaa     3960

atcaagagat ccggcggagg ctccggctac ccctacgacg tgcccgacta tgcattggac     4020

ctgcggcagg gcatgttcgc ccagctggtg gctcagaacg tgctgctgat cgacggcccc     4080

ctgagctggt actctgatcc tggactggct ggcgtgtccc tgaccggcgg actgagctac     4140

aaagaggaca caaaagaact ggtggtggcc aaggccggcg tgtactacgt gttctttcag     4200

ctggaactgc ggagagtggt ggccggcgag ggatctggat ctgtgtctct ggccctgcat     4260

ctgcagcccc tgagatctgc tgctggcgca gctgctctgg ctctgaccgt ggatctgcct     4320

cctgccagca gcgaggccag aaacagcgca ttcgggtttc aaggcaggct gctgcacctg     4380

agcgccggac agagactggg agtgcatctg cacacagagg ccagagccag gcacgcctgg     4440

cagctgacac agggcgctac agtgctgggc ctgttcagag tgacccccga gattcctgcc     4500

ggcctgccta gccctagaag cgaccac                                         4527


