                         SEQUENCE LISTING

<110>  PhaseBio Pharmaceuticals, Inc.
       Jowett, James
       Ballance, David James
 
<120>  ELP FUSION PROTEINS FOR CONTROLLED AND SUSTAINED RELEASE

<130>  PHAS-033/02WO 309646-2248

<140>  PCT/US2017/030403
<141>  2017-05-01

<150>  US 62/442,057
<151>  2017-01-04

<150>  US 62/332,803
<151>  2016-05-06


<160>  134    

<170>  PatentIn version 3.5

<210>  1
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ELP component sequence

<400>  1

Val Pro Gly Gly 
1               


<210>  2
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ELP component sequence

<400>  2

Ile Pro Gly Gly 
1               


<210>  3
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ELP component sequence


<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa can be any naturally occurring or non-natural amino acid

<400>  3

Val Pro Gly Xaa Gly 
1               5   


<210>  4
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ELP component sequence

<400>  4

Ala Val Gly Val Pro 
1               5   


<210>  5
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ELP component sequence


<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa can be any naturally occurring or non-natural amino acid

<400>  5

Ile Pro Gly Xaa Gly 
1               5   


<210>  6
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ELP component sequence

<400>  6

Ile Pro Gly Val Gly 
1               5   


<210>  7
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ELP component sequence


<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa can be any naturally occurring or non-natural amino acid

<400>  7

Leu Pro Gly Xaa Gly 
1               5   


<210>  8
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ELP component sequence

<400>  8

Leu Pro Gly Val Gly 
1               5   


<210>  9
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ELP component sequence

<400>  9

Val Ala Pro Gly Val Gly 
1               5       


<210>  10
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ELP component sequence

<400>  10

Gly Val Gly Val Pro Gly Val Gly 
1               5               


<210>  11
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ELP component sequence

<400>  11

Val Pro Gly Phe Gly Val Gly Ala Gly 
1               5                   


<210>  12
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ELP component sequence

<400>  12

Val Pro Gly Val Gly Val Pro Gly Gly 
1               5                   


<210>  13
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ELP component sequence


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring or non-natural amino acid

<400>  13

Xaa Pro Gly Val Gly 
1               5   


<210>  14
<211>  600
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ELP1-120

<400>  14

Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val 
1               5                   10                  15      


Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro 
            20                  25                  30          


Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly 
        35                  40                  45              


Gly Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly 
    50                  55                  60                  


Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro Gly Val Gly 
65                  70                  75                  80  


Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val 
                85                  90                  95      


Pro Gly Gly Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro 
            100                 105                 110         


Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro Gly 
        115                 120                 125             


Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala 
    130                 135                 140                 


Gly Val Pro Gly Gly Gly Val Pro Gly Val Gly Val Pro Gly Val Gly 
145                 150                 155                 160 


Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly Val 
                165                 170                 175     


Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro 
            180                 185                 190         


Gly Ala Gly Val Pro Gly Gly Gly Val Pro Gly Val Gly Val Pro Gly 
        195                 200                 205             


Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Val 
    210                 215                 220                 


Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly 
225                 230                 235                 240 


Val Pro Gly Ala Gly Val Pro Gly Gly Gly Val Pro Gly Val Gly Val 
                245                 250                 255     


Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro 
            260                 265                 270         


Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly 
        275                 280                 285             


Gly Gly Val Pro Gly Ala Gly Val Pro Gly Gly Gly Val Pro Gly Val 
    290                 295                 300                 


Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly 
305                 310                 315                 320 


Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val 
                325                 330                 335     


Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Gly Gly Val Pro 
            340                 345                 350         


Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly 
        355                 360                 365             


Ala Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Val 
    370                 375                 380                 


Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Gly Gly 
385                 390                 395                 400 


Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val 
                405                 410                 415     


Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro 
            420                 425                 430         


Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly 
        435                 440                 445             


Gly Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly 
    450                 455                 460                 


Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro Gly Val Gly 
465                 470                 475                 480 


Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val 
                485                 490                 495     


Pro Gly Gly Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro 
            500                 505                 510         


Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro Gly 
        515                 520                 525             


Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala 
    530                 535                 540                 


Gly Val Pro Gly Gly Gly Val Pro Gly Val Gly Val Pro Gly Val Gly 
545                 550                 555                 560 


Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly Val 
                565                 570                 575     


Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro 
            580                 585                 590         


Gly Ala Gly Val Pro Gly Gly Gly 
        595                 600 
                 


<210>  15
<211>  155
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ELP1-30

<400>  15

Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val 
1               5                   10                  15      


Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro 
            20                  25                  30          


Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly 
        35                  40                  45              


Gly Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly 
    50                  55                  60                  


Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro Gly Val Gly 
65                  70                  75                  80  


Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val 
                85                  90                  95      


Pro Gly Gly Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro 
            100                 105                 110         


Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro Gly 
        115                 120                 125             


Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala 
    130                 135                 140                 


Gly Val Pro Gly Gly Gly Val Pro Gly Trp Pro 
145                 150                 155 


<210>  16
<211>  730
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ELPbetaV2-144

<400>  16

Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Ala Gly Val 
1               5                   10                  15      


Pro Gly Val Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro 
            20                  25                  30          


Gly Val Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro Gly 
        35                  40                  45              


Ala Gly Val Pro Gly Val Gly Val Pro Gly Ala Gly Val Pro Gly Val 
    50                  55                  60                  


Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro Gly Val Gly 
65                  70                  75                  80  


Val Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro Gly Ala Gly Val 
                85                  90                  95      


Pro Gly Val Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro 
            100                 105                 110         


Gly Ala Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly 
        115                 120                 125             


Ala Gly Val Pro Gly Val Gly Val Pro Gly Ala Gly Val Pro Gly Val 
    130                 135                 140                 


Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro Gly Ala Gly 
145                 150                 155                 160 


Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Ala Gly Val 
                165                 170                 175     


Pro Gly Val Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro 
            180                 185                 190         


Gly Ala Gly Val Pro Gly Val Gly Val Pro Gly Ala Gly Val Pro Gly 
        195                 200                 205             


Val Gly Val Pro Gly Val Gly Val Pro Gly Ala Gly Val Pro Gly Val 
    210                 215                 220                 


Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro Gly Ala Gly 
225                 230                 235                 240 


Val Pro Gly Val Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly Val 
                245                 250                 255     


Pro Gly Val Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro 
            260                 265                 270         


Gly Ala Gly Val Pro Gly Val Gly Val Pro Gly Ala Gly Val Pro Gly 
        275                 280                 285             


Val Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro Gly Val 
    290                 295                 300                 


Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro Gly Ala Gly 
305                 310                 315                 320 


Val Pro Gly Val Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly Val 
                325                 330                 335     


Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro 
            340                 345                 350         


Gly Ala Gly Val Pro Gly Val Gly Val Pro Gly Ala Gly Val Pro Gly 
        355                 360                 365             


Val Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro Gly Ala 
    370                 375                 380                 


Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Ala Gly 
385                 390                 395                 400 


Val Pro Gly Val Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly Val 
                405                 410                 415     


Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro Gly Ala Gly Val Pro 
            420                 425                 430         


Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Ala Gly Val Pro Gly 
        435                 440                 445             


Val Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro Gly Ala 
    450                 455                 460                 


Gly Val Pro Gly Val Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly 
465                 470                 475                 480 


Val Pro Gly Val Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly Val 
                485                 490                 495     


Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro Gly Ala Gly Val Pro 
            500                 505                 510         


Gly Val Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro Gly 
        515                 520                 525             


Val Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro Gly Ala 
    530                 535                 540                 


Gly Val Pro Gly Val Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly 
545                 550                 555                 560 


Val Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val 
                565                 570                 575     


Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro Gly Ala Gly Val Pro 
            580                 585                 590         


Gly Val Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro Gly 
        595                 600                 605             


Ala Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Ala 
    610                 615                 620                 


Gly Val Pro Gly Val Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly 
625                 630                 635                 640 


Val Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro Gly Ala Gly Val 
                645                 650                 655     


Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Ala Gly Val Pro 
            660                 665                 670         


Gly Val Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro Gly 
        675                 680                 685             


Ala Gly Val Pro Gly Val Gly Val Pro Gly Ala Gly Val Pro Gly Val 
    690                 695                 700                 


Gly Val Pro Gly Val Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly 
705                 710                 715                 720 


Val Pro Gly Ala Gly Val Pro Gly Val Gly 
                725                 730 


<210>  17
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human recombinant Exendin-4

<400>  17

His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Met Glu Glu 
1               5                   10                  15      


Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Asn Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  18
<211>  31
<212>  PRT
<213>  Unknown

<220>
<223>  Exendin-4 (1-31)

<400>  18

His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Met Glu Glu 
1               5                   10                  15      


Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Asn Gly Gly Pro 
            20                  25                  30      


<210>  19
<211>  30
<212>  PRT
<213>  Unknown

<220>
<223>  Exendin-4 (1-30)

<400>  19

His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Met Glu Glu 
1               5                   10                  15      


Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Asn Gly Gly 
            20                  25                  30  


<210>  20
<211>  32
<212>  PRT
<213>  Unknown

<220>
<223>  Exendin-4 (1-32)

<400>  20

His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Met Glu Glu 
1               5                   10                  15      


Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Asn Gly Gly Pro Ser 
            20                  25                  30          


<210>  21
<211>  33
<212>  PRT
<213>  Unknown

<220>
<223>  Exendin-4 (1-33)

<400>  21

His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Met Glu Glu 
1               5                   10                  15      


Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Asn Gly Gly Pro Ser 
            20                  25                  30          


Ser 
    


<210>  22
<211>  34
<212>  PRT
<213>  Unknown

<220>
<223>  Exendin-4 (1-34)

<400>  22

His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Met Glu Glu 
1               5                   10                  15      


Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Asn Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly 
        


<210>  23
<211>  35
<212>  PRT
<213>  Unknown

<220>
<223>  Exendin-4 (1-35)

<400>  23

His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Met Glu Glu 
1               5                   10                  15      


Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Asn Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala 
        35  


<210>  24
<211>  36
<212>  PRT
<213>  Unknown

<220>
<223>  Exendin-4 (1-36)

<400>  24

His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Met Glu Glu 
1               5                   10                  15      


Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Asn Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro 
        35      


<210>  25
<211>  37
<212>  PRT
<213>  Unknown

<220>
<223>  Exendin-4 (1-37)

<400>  25

His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Met Glu Glu 
1               5                   10                  15      


Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Asn Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro 
        35          


<210>  26
<211>  38
<212>  PRT
<213>  Unknown

<220>
<223>  Exendin-4 (1-38)

<400>  26

His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Met Glu Glu 
1               5                   10                  15      


Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Asn Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro 
        35              


<210>  27
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human recombinant Exendin-4 (9-39)

<400>  27

Asp Leu Ser Lys Gln Met Glu Glu Glu Ala Val Arg Leu Phe Ile Glu 
1               5                   10                  15      


Trp Leu Lys Asn Gly Gly Pro Ser Ser Gly Ala Pro Pro Pro Ser 
            20                  25                  30      


<210>  28
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human recombinant Exendin-4 (9-31)

<400>  28

Asp Leu Ser Lys Gln Met Glu Glu Glu Ala Val Arg Leu Phe Ile Glu 
1               5                   10                  15      


Trp Leu Lys Asn Gly Gly Pro 
            20              


<210>  29
<211>  46
<212>  PRT
<213>  Unknown

<220>
<223>  Exendin-4-ELP sequence with N-terminal Tev cleavage site

<400>  29

Met Glu Asn Leu Tyr Phe Gln His Gly Glu Gly Thr Phe Thr Ser Asp 
1               5                   10                  15      


Leu Ser Lys Gln Met Glu Glu Glu Ala Val Arg Leu Phe Ile Glu Trp 
            20                  25                  30          


Leu Lys Asn Gly Gly Pro Ser Ser Gly Ala Pro Pro Pro Ser 
        35                  40                  45      


<210>  30
<211>  58
<212>  PRT
<213>  Unknown

<220>
<223>  Exendin-4-ELP sequence with DsbA leader sequence

<400>  30

Met Lys Lys Ile Trp Leu Ala Leu Ala Gly Leu Val Leu Ala Phe Ser 
1               5                   10                  15      


Ala Ser Ala His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln 
            20                  25                  30          


Met Glu Glu Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Asn Gly 
        35                  40                  45              


Gly Pro Ser Ser Gly Ala Pro Pro Pro Ser 
    50                  55              


<210>  31
<211>  31
<212>  PRT
<213>  Unknown

<220>
<223>  GLP-1 (A8G 7-37)

<400>  31

His Gly Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Arg Gly 
            20                  25                  30      


<210>  32
<211>  30
<212>  PRT
<213>  Unknown

<220>
<223>  GLP-1(7-36)

<400>  32

His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Arg 
            20                  25                  30  


<210>  33
<211>  30
<212>  PRT
<213>  Unknown

<220>
<223>  GLP-1(7-36) with G at position 2

<400>  33

His Gly Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Arg 
            20                  25                  30  


<210>  34
<211>  38
<212>  PRT
<213>  Unknown

<220>
<223>  GLP-1(A8G 1-37)

<400>  34

Met Glu Asn Leu Tyr Phe Gln His Gly Glu Gly Thr Phe Thr Ser Asp 
1               5                   10                  15      


Val Ser Ser Tyr Leu Glu Gly Gln Ala Ala Lys Glu Phe Ile Ala Trp 
            20                  25                  30          


Leu Val Lys Gly Arg Gly 
        35              


<210>  35
<211>  44
<212>  PRT
<213>  Unknown

<220>
<223>  GLP-1 receptor agonist

<400>  35

His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Met Glu Glu 
1               5                   10                  15      


Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Asn Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Ser Lys Lys Lys Lys Lys Lys 
        35                  40                  


<210>  36
<211>  31
<212>  PRT
<213>  Unknown

<220>
<223>  GLP-1 receptor agonist

<400>  36

His Val Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Ile Lys Gly Arg Gly 
            20                  25                  30      


<210>  37
<211>  48
<212>  PRT
<213>  Unknown

<220>
<223>  GLP-1 A8G

<400>  37

Met Glu Asn Leu Tyr Phe Gln His Gly Glu Gly Thr Phe Thr Ser Asp 
1               5                   10                  15      


Val Ser Ser Tyr Leu Glu Gly Gln Ala Ala Lys Glu Phe Ile Ala Trp 
            20                  25                  30          


Leu Val Lys Gly Arg Gly Leu Glu Gly Met Gly Gly Pro Gly Val Gly 
        35                  40                  45              


<210>  38
<211>  22
<212>  PRT
<213>  Unknown

<220>
<223>  Exendin-4 (9-30)

<400>  38

Asp Leu Ser Lys Gln Met Glu Glu Glu Ala Val Arg Leu Phe Ile Glu 
1               5                   10                  15      


Trp Leu Lys Asn Gly Gly 
            20          


<210>  39
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human recombinant apelin-36

<400>  39

Leu Val Gln Pro Arg Gly Ser Arg Asn Gly Pro Gly Pro Trp Gln Gly 
1               5                   10                  15      


Gly Arg Arg Lys Phe Arg Arg Gln Arg Pro Arg Leu Ser His Lys Gly 
            20                  25                  30          


Pro Met Pro Phe 
        35      


<210>  40
<211>  642
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pPE0518-ELP1-120 apelin-36

<400>  40

Met Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly 
1               5                   10                  15      


Val Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val 
            20                  25                  30          


Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro 
        35                  40                  45              


Gly Gly Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly 
    50                  55                  60                  


Gly Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro Gly Val 
65                  70                  75                  80  


Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly 
                85                  90                  95      


Val Pro Gly Gly Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val 
            100                 105                 110         


Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro 
        115                 120                 125             


Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly 
    130                 135                 140                 


Ala Gly Val Pro Gly Gly Gly Val Pro Gly Val Gly Val Pro Gly Val 
145                 150                 155                 160 


Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly 
                165                 170                 175     


Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val 
            180                 185                 190         


Pro Gly Ala Gly Val Pro Gly Gly Gly Val Pro Gly Val Gly Val Pro 
        195                 200                 205             


Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly 
    210                 215                 220                 


Val Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly 
225                 230                 235                 240 


Gly Val Pro Gly Ala Gly Val Pro Gly Gly Gly Val Pro Gly Val Gly 
                245                 250                 255     


Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val 
            260                 265                 270         


Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro 
        275                 280                 285             


Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Gly Gly Val Pro Gly 
    290                 295                 300                 


Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala 
305                 310                 315                 320 


Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Val Gly 
                325                 330                 335     


Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Gly Gly Val 
            340                 345                 350         


Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro 
        355                 360                 365             


Gly Ala Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly 
    370                 375                 380                 


Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Gly 
385                 390                 395                 400 


Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly 
                405                 410                 415     


Val Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val 
            420                 425                 430         


Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro 
        435                 440                 445             


Gly Gly Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly 
    450                 455                 460                 


Gly Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro Gly Val 
465                 470                 475                 480 


Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly 
                485                 490                 495     


Val Pro Gly Gly Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val 
            500                 505                 510         


Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro 
        515                 520                 525             


Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly 
    530                 535                 540                 


Ala Gly Val Pro Gly Gly Gly Val Pro Gly Val Gly Val Pro Gly Val 
545                 550                 555                 560 


Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly 
                565                 570                 575     


Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val 
            580                 585                 590         


Pro Gly Ala Gly Val Pro Gly Gly Gly Val Pro Gly Val Gly Leu Val 
        595                 600                 605             


Gln Pro Arg Gly Ser Arg Asn Gly Pro Gly Pro Trp Gln Gly Gly Arg 
    610                 615                 620                 


Arg Lys Phe Arg Arg Gln Arg Pro Arg Leu Ser His Lys Gly Pro Met 
625                 630                 635                 640 


Pro Phe 
        


<210>  41
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human recombinant Apelin-17

<400>  41

Lys Phe Arg Arg Gln Arg Pro Arg Leu Ser His Lys Gly Pro Met Pro 
1               5                   10                  15      


Phe 
    


<210>  42
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human recombinant Pyr-apelin-13


<220>
<221>  MISC_FEATURE
<222>  (1)..()
<223>  May be modified with a Pyroglutamate moiety

<400>  42

Arg Pro Arg Leu Ser His Lys Gly Pro Met Pro Phe 
1               5                   10          


<210>  43
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human recombinant Apelin-13

<400>  43

Gln Arg Pro Arg Leu Ser His Lys Gly Pro Met Pro Phe 
1               5                   10              


<210>  44
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human recombinant Apelin-12

<400>  44

Arg Pro Arg Leu Ser His Lys Gly Pro Met Pro Phe 
1               5                   10          


<210>  45
<211>  322
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human recombinant arginase

<400>  45

Met Ser Ala Lys Ser Arg Thr Ile Gly Ile Ile Gly Ala Pro Phe Ser 
1               5                   10                  15      


Lys Gly Gln Pro Arg Gly Gly Val Glu Glu Gly Pro Thr Val Leu Arg 
            20                  25                  30          


Lys Ala Gly Leu Leu Glu Lys Leu Lys Glu Gln Glu Cys Asp Val Lys 
        35                  40                  45              


Asp Tyr Gly Asp Leu Pro Phe Ala Asp Ile Pro Asn Asp Ser Pro Phe 
    50                  55                  60                  


Gln Ile Val Lys Asn Pro Arg Ser Val Gly Lys Ala Ser Glu Gln Leu 
65                  70                  75                  80  


Ala Gly Lys Val Ala Glu Val Lys Lys Asn Gly Arg Ile Ser Leu Val 
                85                  90                  95      


Leu Gly Gly Asp His Ser Leu Ala Ile Gly Ser Ile Ser Gly His Ala 
            100                 105                 110         


Arg Val His Pro Asp Leu Gly Val Ile Trp Val Asp Ala His Thr Asp 
        115                 120                 125             


Ile Asn Thr Pro Leu Thr Thr Thr Ser Gly Asn Leu His Gly Gln Pro 
    130                 135                 140                 


Val Ser Phe Leu Leu Lys Glu Leu Lys Gly Lys Ile Pro Asp Val Pro 
145                 150                 155                 160 


Gly Phe Ser Trp Val Thr Pro Cys Ile Ser Ala Lys Asp Ile Val Tyr 
                165                 170                 175     


Ile Gly Leu Arg Asp Val Asp Pro Gly Glu His Tyr Ile Leu Lys Thr 
            180                 185                 190         


Leu Gly Ile Lys Tyr Phe Ser Met Thr Glu Val Asp Arg Leu Gly Ile 
        195                 200                 205             


Gly Lys Val Met Glu Glu Thr Leu Ser Tyr Leu Leu Gly Arg Lys Lys 
    210                 215                 220                 


Arg Pro Ile His Leu Ser Phe Asp Val Asp Gly Leu Asp Pro Ser Phe 
225                 230                 235                 240 


Thr Pro Ala Thr Gly Thr Pro Val Val Gly Gly Leu Thr Tyr Arg Glu 
                245                 250                 255     


Gly Leu Tyr Ile Thr Glu Glu Ile Tyr Lys Thr Gly Leu Leu Ser Gly 
            260                 265                 270         


Leu Asp Ile Met Glu Val Asn Pro Ser Leu Gly Lys Thr Pro Glu Glu 
        275                 280                 285             


Val Thr Arg Thr Val Asn Thr Ala Val Ala Ile Thr Leu Ala Cys Phe 
    290                 295                 300                 


Gly Leu Ala Arg Glu Gly Asn His Lys Pro Ile Asp Tyr Leu Asn Pro 
305                 310                 315                 320 


Pro Lys 
        


<210>  46
<211>  927
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pPE0140-arginase ELP1-120

<400>  46

Met Ser Ala Lys Ser Arg Thr Ile Gly Ile Ile Gly Ala Pro Phe Ser 
1               5                   10                  15      


Lys Gly Gln Pro Arg Gly Gly Val Glu Glu Gly Pro Thr Val Leu Arg 
            20                  25                  30          


Lys Ala Gly Leu Leu Glu Lys Leu Lys Glu Gln Glu Cys Asp Val Lys 
        35                  40                  45              


Asp Tyr Gly Asp Leu Pro Phe Ala Asp Ile Pro Asn Asp Ser Pro Phe 
    50                  55                  60                  


Gln Ile Val Lys Asn Pro Arg Ser Val Gly Lys Ala Ser Glu Gln Leu 
65                  70                  75                  80  


Ala Gly Lys Val Ala Glu Val Lys Lys Asn Gly Arg Ile Ser Leu Val 
                85                  90                  95      


Leu Gly Gly Asp His Ser Leu Ala Ile Gly Ser Ile Ser Gly His Ala 
            100                 105                 110         


Arg Val His Pro Asp Leu Gly Val Ile Trp Val Asp Ala His Thr Asp 
        115                 120                 125             


Ile Asn Thr Pro Leu Thr Thr Thr Ser Gly Asn Leu His Gly Gln Pro 
    130                 135                 140                 


Val Ser Phe Leu Leu Lys Glu Leu Lys Gly Lys Ile Pro Asp Val Pro 
145                 150                 155                 160 


Gly Phe Ser Trp Val Thr Pro Cys Ile Ser Ala Lys Asp Ile Val Tyr 
                165                 170                 175     


Ile Gly Leu Arg Asp Val Asp Pro Gly Glu His Tyr Ile Leu Lys Thr 
            180                 185                 190         


Leu Gly Ile Lys Tyr Phe Ser Met Thr Glu Val Asp Arg Leu Gly Ile 
        195                 200                 205             


Gly Lys Val Met Glu Glu Thr Leu Ser Tyr Leu Leu Gly Arg Lys Lys 
    210                 215                 220                 


Arg Pro Ile His Leu Ser Phe Asp Val Asp Gly Leu Asp Pro Ser Phe 
225                 230                 235                 240 


Thr Pro Ala Thr Gly Thr Pro Val Val Gly Gly Leu Thr Tyr Arg Glu 
                245                 250                 255     


Gly Leu Tyr Ile Thr Glu Glu Ile Tyr Lys Thr Gly Leu Leu Ser Gly 
            260                 265                 270         


Leu Asp Ile Met Glu Val Asn Pro Ser Leu Gly Lys Thr Pro Glu Glu 
        275                 280                 285             


Val Thr Arg Thr Val Asn Thr Ala Val Ala Ile Thr Leu Ala Cys Phe 
    290                 295                 300                 


Gly Leu Ala Arg Glu Gly Asn His Lys Pro Ile Asp Tyr Leu Asn Pro 
305                 310                 315                 320 


Pro Lys Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly 
                325                 330                 335     


Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro Gly Val Gly 
            340                 345                 350         


Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val 
        355                 360                 365             


Pro Gly Gly Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro 
    370                 375                 380                 


Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro Gly 
385                 390                 395                 400 


Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala 
                405                 410                 415     


Gly Val Pro Gly Gly Gly Val Pro Gly Val Gly Val Pro Gly Val Gly 
            420                 425                 430         


Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly Val 
        435                 440                 445             


Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro 
    450                 455                 460                 


Gly Ala Gly Val Pro Gly Gly Gly Val Pro Gly Val Gly Val Pro Gly 
465                 470                 475                 480 


Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Val 
                485                 490                 495     


Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly 
            500                 505                 510         


Val Pro Gly Ala Gly Val Pro Gly Gly Gly Val Pro Gly Val Gly Val 
        515                 520                 525             


Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro 
    530                 535                 540                 


Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly 
545                 550                 555                 560 


Gly Gly Val Pro Gly Ala Gly Val Pro Gly Gly Gly Val Pro Gly Val 
                565                 570                 575     


Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly 
            580                 585                 590         


Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val 
        595                 600                 605             


Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Gly Gly Val Pro 
    610                 615                 620                 


Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly 
625                 630                 635                 640 


Ala Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Val 
                645                 650                 655     


Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Gly Gly 
            660                 665                 670         


Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val 
        675                 680                 685             


Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro 
    690                 695                 700                 


Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly 
705                 710                 715                 720 


Gly Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly 
                725                 730                 735     


Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro Gly Val Gly 
            740                 745                 750         


Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val 
        755                 760                 765             


Pro Gly Gly Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro 
    770                 775                 780                 


Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro Gly 
785                 790                 795                 800 


Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala 
                805                 810                 815     


Gly Val Pro Gly Gly Gly Val Pro Gly Val Gly Val Pro Gly Val Gly 
            820                 825                 830         


Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly Val 
        835                 840                 845             


Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro 
    850                 855                 860                 


Gly Ala Gly Val Pro Gly Gly Gly Val Pro Gly Val Gly Val Pro Gly 
865                 870                 875                 880 


Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Val 
                885                 890                 895     


Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly 
            900                 905                 910         


Val Pro Gly Ala Gly Val Pro Gly Gly Gly Val Pro Gly Trp Pro 
        915                 920                 925         




<210>  47
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human recombinant CNP22

<400>  47

Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser 
1               5                   10                  15      


Met Ser Gly Leu Gly Cys 
            20          

<210>  48
<211>  628
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ELP1-120 CNP22 fusion

<400>  48

Met Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly 
1               5                   10                  15      


Val Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val 
            20                  25                  30          


Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro 
        35                  40                  45              


Gly Gly Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly 
    50                  55                  60                  


Gly Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro Gly Val 
65                  70                  75                  80  


Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly 
                85                  90                  95      


Val Pro Gly Gly Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val 
            100                 105                 110         


Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro 
        115                 120                 125             


Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly 
    130                 135                 140                 


Ala Gly Val Pro Gly Gly Gly Val Pro Gly Val Gly Val Pro Gly Val 
145                 150                 155                 160 


Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly 
                165                 170                 175     


Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val 
            180                 185                 190         


Pro Gly Ala Gly Val Pro Gly Gly Gly Val Pro Gly Val Gly Val Pro 
        195                 200                 205             


Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly 
    210                 215                 220                 


Val Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly 
225                 230                 235                 240 


Gly Val Pro Gly Ala Gly Val Pro Gly Gly Gly Val Pro Gly Val Gly 
                245                 250                 255     


Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val 
            260                 265                 270         


Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro 
        275                 280                 285             


Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Gly Gly Val Pro Gly 
    290                 295                 300                 


Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala 
305                 310                 315                 320 


Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Val Gly 
                325                 330                 335     


Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Gly Gly Val 
            340                 345                 350         


Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro 
        355                 360                 365             


Gly Ala Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly 
    370                 375                 380                 


Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Gly 
385                 390                 395                 400 


Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly 
                405                 410                 415     


Val Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val 
            420                 425                 430         


Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro 
        435                 440                 445             


Gly Gly Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly 
    450                 455                 460                 


Gly Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro Gly Val 
465                 470                 475                 480 


Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly 
                485                 490                 495     


Val Pro Gly Gly Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val 
            500                 505                 510         


Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro 
        515                 520                 525             


Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly 
    530                 535                 540                 


Ala Gly Val Pro Gly Gly Gly Val Pro Gly Val Gly Val Pro Gly Val 
545                 550                 555                 560 


Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly 
                565                 570                 575     


Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val 
            580                 585                 590         


Pro Gly Ala Gly Val Pro Gly Gly Gly Val Pro Gly Trp Gly Gly Leu 
        595                 600                 605             


Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser Met Ser 
    610                 615                 620                 


Gly Leu Gly Cys 
625             


<210>  49
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human recombinant CNP37

<400>  49

Gln Glu His Pro Asn Ala Arg Lys Tyr Lys Gly Ala Asn Lys Lys Gly 
1               5                   10                  15      


Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser Met 
            20                  25                  30          


Ser Gly Leu Gly Cys 
        35          


<210>  50
<211>  643
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pPE0493-ELP1-120 CNP37

<400>  50

Met Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly 
1               5                   10                  15      


Val Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val 
            20                  25                  30          


Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro 
        35                  40                  45              


Gly Gly Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly 
    50                  55                  60                  


Gly Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro Gly Val 
65                  70                  75                  80  


Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly 
                85                  90                  95      


Val Pro Gly Gly Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val 
            100                 105                 110         


Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro 
        115                 120                 125             


Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly 
    130                 135                 140                 


Ala Gly Val Pro Gly Gly Gly Val Pro Gly Val Gly Val Pro Gly Val 
145                 150                 155                 160 


Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly 
                165                 170                 175     


Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val 
            180                 185                 190         


Pro Gly Ala Gly Val Pro Gly Gly Gly Val Pro Gly Val Gly Val Pro 
        195                 200                 205             


Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly 
    210                 215                 220                 


Val Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly 
225                 230                 235                 240 


Gly Val Pro Gly Ala Gly Val Pro Gly Gly Gly Val Pro Gly Val Gly 
                245                 250                 255     


Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val 
            260                 265                 270         


Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro 
        275                 280                 285             


Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Gly Gly Val Pro Gly 
    290                 295                 300                 


Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala 
305                 310                 315                 320 


Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Val Gly 
                325                 330                 335     


Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Gly Gly Val 
            340                 345                 350         


Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro 
        355                 360                 365             


Gly Ala Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly 
    370                 375                 380                 


Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Gly 
385                 390                 395                 400 


Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly 
                405                 410                 415     


Val Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val 
            420                 425                 430         


Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro 
        435                 440                 445             


Gly Gly Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly 
    450                 455                 460                 


Gly Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro Gly Val 
465                 470                 475                 480 


Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly 
                485                 490                 495     


Val Pro Gly Gly Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val 
            500                 505                 510         


Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro 
        515                 520                 525             


Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly 
    530                 535                 540                 


Ala Gly Val Pro Gly Gly Gly Val Pro Gly Val Gly Val Pro Gly Val 
545                 550                 555                 560 


Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly 
                565                 570                 575     


Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val 
            580                 585                 590         


Pro Gly Ala Gly Val Pro Gly Gly Gly Val Pro Gly Trp Gly Gln Glu 
        595                 600                 605             


His Pro Asn Ala Arg Lys Tyr Lys Gly Ala Asn Lys Lys Gly Leu Ser 
    610                 615                 620                 


Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser Met Ser Gly 
625                 630                 635                 640 


Leu Gly Cys 
            


<210>  51
<211>  53
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human recombinant CNP-53

<400>  51

Asp Leu Arg Val Asp Thr Lys Ser Arg Ala Ala Trp Ala Arg Leu Leu 
1               5                   10                  15      


Gln Glu His Pro Asn Ala Arg Lys Tyr Lys Gly Ala Asn Lys Lys Gly 
            20                  25                  30          


Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser Met 
        35                  40                  45              


Ser Gly Leu Gly Cys 
    50              


<210>  52
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human recombinant CNP-39

<400>  52

Pro Gly Gln Glu His Pro Asn Ala Arg Lys Tyr Lys Gly Ala Asn Lys 
1               5                   10                  15      


Lys Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly 
            20                  25                  30          


Ser Met Ser Gly Leu Gly Cys 
        35                  


<210>  53
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human recombinant GLP-1

<400>  53

His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Arg Gly 
            20                  25                  30      


<210>  54
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human recombinant GLP-1 (9-31)

<400>  54

Asp Val Ser Ser Tyr Leu Glu Gly Gln Ala Ala Lys Glu Phe Ile Ala 
1               5                   10                  15      


Trp Leu Val Lys Gly Arg 
            20          


<210>  55
<211>  633
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CNP22 GGS2X ELP1-120 fusion

<400>  55

Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser 
1               5                   10                  15      


Met Ser Gly Leu Gly Cys Gly Gly Ser Gly Gly Ser Val Pro Gly Val 
            20                  25                  30          


Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly 
        35                  40                  45              


Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val 
    50                  55                  60                  


Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Gly Gly Val Pro 
65                  70                  75                  80  


Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly 
                85                  90                  95      


Ala Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Val 
            100                 105                 110         


Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Gly Gly 
        115                 120                 125             


Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val 
    130                 135                 140                 


Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro 
145                 150                 155                 160 


Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly 
                165                 170                 175     


Gly Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly 
            180                 185                 190         


Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro Gly Val Gly 
        195                 200                 205             


Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val 
    210                 215                 220                 


Pro Gly Gly Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro 
225                 230                 235                 240 


Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro Gly 
                245                 250                 255     


Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala 
            260                 265                 270         


Gly Val Pro Gly Gly Gly Val Pro Gly Val Gly Val Pro Gly Val Gly 
        275                 280                 285             


Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly Val 
    290                 295                 300                 


Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro 
305                 310                 315                 320 


Gly Ala Gly Val Pro Gly Gly Gly Val Pro Gly Val Gly Val Pro Gly 
                325                 330                 335     


Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Val 
            340                 345                 350         


Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly 
        355                 360                 365             


Val Pro Gly Ala Gly Val Pro Gly Gly Gly Val Pro Gly Val Gly Val 
    370                 375                 380                 


Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro 
385                 390                 395                 400 


Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly 
                405                 410                 415     


Gly Gly Val Pro Gly Ala Gly Val Pro Gly Gly Gly Val Pro Gly Val 
            420                 425                 430         


Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly 
        435                 440                 445             


Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val 
    450                 455                 460                 


Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Gly Gly Val Pro 
465                 470                 475                 480 


Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly 
                485                 490                 495     


Ala Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Val 
            500                 505                 510         


Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Gly Gly 
        515                 520                 525             


Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val 
    530                 535                 540                 


Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro 
545                 550                 555                 560 


Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly 
                565                 570                 575     


Gly Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly 
            580                 585                 590         


Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro Gly Val Gly 
        595                 600                 605             


Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val 
    610                 615                 620                 


Pro Gly Gly Gly Val Pro Gly Trp Pro 
625                 630             

<210>  56
<211>  732
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ELP1-120 pro-CNP

<400>  56

Met Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly 
1               5                   10                  15      


Val Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val 
            20                  25                  30          


Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro 
        35                  40                  45              


Gly Gly Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly 
    50                  55                  60                  


Gly Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro Gly Val 
65                  70                  75                  80  


Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly 
                85                  90                  95      


Val Pro Gly Gly Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val 
            100                 105                 110         


Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro 
        115                 120                 125             


Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly 
    130                 135                 140                 


Ala Gly Val Pro Gly Gly Gly Val Pro Gly Val Gly Val Pro Gly Val 
145                 150                 155                 160 


Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly 
                165                 170                 175     


Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val 
            180                 185                 190         


Pro Gly Ala Gly Val Pro Gly Gly Gly Val Pro Gly Val Gly Val Pro 
        195                 200                 205             


Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly 
    210                 215                 220                 


Val Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly 
225                 230                 235                 240 


Gly Val Pro Gly Ala Gly Val Pro Gly Gly Gly Val Pro Gly Val Gly 
                245                 250                 255     


Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val 
            260                 265                 270         


Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro 
        275                 280                 285             


Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Gly Gly Val Pro Gly 
    290                 295                 300                 


Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala 
305                 310                 315                 320 


Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Val Gly 
                325                 330                 335     


Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Gly Gly Val 
            340                 345                 350         


Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro 
        355                 360                 365             


Gly Ala Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly 
    370                 375                 380                 


Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Gly 
385                 390                 395                 400 


Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly 
                405                 410                 415     


Val Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val 
            420                 425                 430         


Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro 
        435                 440                 445             


Gly Gly Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly 
    450                 455                 460                 


Gly Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro Gly Val 
465                 470                 475                 480 


Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly 
                485                 490                 495     


Val Pro Gly Gly Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val 
            500                 505                 510         


Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro 
        515                 520                 525             


Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly 
    530                 535                 540                 


Ala Gly Val Pro Gly Gly Gly Val Pro Gly Val Gly Val Pro Gly Val 
545                 550                 555                 560 


Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly 
                565                 570                 575     


Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val 
            580                 585                 590         


Pro Gly Ala Gly Val Pro Gly Gly Gly Val Pro Gly Val Gly Met His 
        595                 600                 605             


Leu Ser Gln Leu Leu Ala Cys Ala Leu Leu Leu Thr Leu Leu Ser Leu 
    610                 615                 620                 


Arg Pro Ser Glu Ala Lys Pro Gly Ala Pro Pro Lys Val Pro Arg Thr 
625                 630                 635                 640 


Pro Pro Ala Glu Glu Leu Ala Glu Pro Gln Ala Ala Gly Gly Gly Gln 
                645                 650                 655     


Lys Lys Gly Asp Lys Ala Pro Gly Gly Gly Gly Ala Asn Leu Lys Gly 
            660                 665                 670         


Asp Arg Ser Arg Leu Leu Arg Asp Leu Arg Val Asp Thr Lys Ser Arg 
        675                 680                 685             


Ala Ala Trp Ala Arg Leu Leu Gln Glu His Pro Asn Ala Arg Lys Tyr 
    690                 695                 700                 


Lys Gly Ala Asn Lys Lys Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys 
705                 710                 715                 720 


Leu Asp Arg Ile Gly Ser Met Ser Gly Leu Gly Cys 
                725                 730         

    

<210>  57
<211>  643
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CNP37 ELP1-120 fusion

<400>  57

Gln Glu His Pro Asn Ala Arg Lys Tyr Lys Gly Ala Asn Lys Lys Gly 
1               5                   10                  15      


Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser Met 
            20                  25                  30          


Ser Gly Leu Gly Cys Gly Val Pro Gly Val Gly Val Pro Gly Val Gly 
        35                  40                  45              


Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly Val 
    50                  55                  60                  


Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro 
65                  70                  75                  80  


Gly Ala Gly Val Pro Gly Gly Gly Val Pro Gly Val Gly Val Pro Gly 
                85                  90                  95      


Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Val 
            100                 105                 110         


Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly 
        115                 120                 125             


Val Pro Gly Ala Gly Val Pro Gly Gly Gly Val Pro Gly Val Gly Val 
    130                 135                 140                 


Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro 
145                 150                 155                 160 


Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly 
                165                 170                 175     


Gly Gly Val Pro Gly Ala Gly Val Pro Gly Gly Gly Val Pro Gly Val 
            180                 185                 190         


Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly 
        195                 200                 205             


Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val 
    210                 215                 220                 


Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Gly Gly Val Pro 
225                 230                 235                 240 


Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly 
                245                 250                 255     


Ala Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Val 
            260                 265                 270         


Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Gly Gly 
        275                 280                 285             


Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val 
    290                 295                 300                 


Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro 
305                 310                 315                 320 


Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly 
                325                 330                 335     


Gly Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly 
            340                 345                 350         


Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro Gly Val Gly 
        355                 360                 365             


Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val 
    370                 375                 380                 


Pro Gly Gly Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro 
385                 390                 395                 400 


Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro Gly 
                405                 410                 415     


Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala 
            420                 425                 430         


Gly Val Pro Gly Gly Gly Val Pro Gly Val Gly Val Pro Gly Val Gly 
        435                 440                 445             


Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly Val 
    450                 455                 460                 


Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro 
465                 470                 475                 480 


Gly Ala Gly Val Pro Gly Gly Gly Val Pro Gly Val Gly Val Pro Gly 
                485                 490                 495     


Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Val 
            500                 505                 510         


Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly 
        515                 520                 525             


Val Pro Gly Ala Gly Val Pro Gly Gly Gly Val Pro Gly Val Gly Val 
    530                 535                 540                 


Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro 
545                 550                 555                 560 


Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly 
                565                 570                 575     


Gly Gly Val Pro Gly Ala Gly Val Pro Gly Gly Gly Val Pro Gly Val 
            580                 585                 590         


Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly 
        595                 600                 605             


Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val 
    610                 615                 620                 


Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Gly Gly Val Pro 
625                 630                 635                 640 


Gly Trp Pro


<210>  58
<211>  628
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pPE0497-Exendin-4 (9-31)-ELP1-120 

<400>  58

Asp Leu Ser Lys Gln Met Glu Glu Glu Ala Val Arg Leu Phe Ile Glu 
1               5                   10                  15      


Trp Leu Lys Asn Gly Gly Pro Val Pro Gly Val Gly Val Pro Gly Val 
            20                  25                  30          


Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly 
        35                  40                  45              


Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val 
    50                  55                  60                  


Pro Gly Ala Gly Val Pro Gly Gly Gly Val Pro Gly Val Gly Val Pro 
65                  70                  75                  80  


Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly 
                85                  90                  95      


Val Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly 
            100                 105                 110         


Gly Val Pro Gly Ala Gly Val Pro Gly Gly Gly Val Pro Gly Val Gly 
        115                 120                 125             


Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val 
    130                 135                 140                 


Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro 
145                 150                 155                 160 


Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Gly Gly Val Pro Gly 
                165                 170                 175     


Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala 
            180                 185                 190         


Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Val Gly 
        195                 200                 205             


Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Gly Gly Val 
    210                 215                 220                 


Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro 
225                 230                 235                 240 


Gly Ala Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly 
                245                 250                 255     


Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Gly 
            260                 265                 270         


Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly 
        275                 280                 285             


Val Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val 
    290                 295                 300                 


Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro 
305                 310                 315                 320 


Gly Gly Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly 
                325                 330                 335     


Gly Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro Gly Val 
            340                 345                 350         


Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly 
        355                 360                 365             


Val Pro Gly Gly Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val 
    370                 375                 380                 


Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro 
385                 390                 395                 400 


Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly 
                405                 410                 415     


Ala Gly Val Pro Gly Gly Gly Val Pro Gly Val Gly Val Pro Gly Val 
            420                 425                 430         


Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly 
        435                 440                 445             


Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val 
    450                 455                 460                 


Pro Gly Ala Gly Val Pro Gly Gly Gly Val Pro Gly Val Gly Val Pro 
465                 470                 475                 480 


Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly 
                485                 490                 495     


Val Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly 
            500                 505                 510         


Gly Val Pro Gly Ala Gly Val Pro Gly Gly Gly Val Pro Gly Val Gly 
        515                 520                 525             


Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val 
    530                 535                 540                 


Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro 
545                 550                 555                 560 


Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Gly Gly Val Pro Gly 
                565                 570                 575     


Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala 
            580                 585                 590         


Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Val Gly 
        595                 600                 605             


Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Gly Gly Val 
    610                 615                 620                 


Pro Gly Trp Pro 
625             


<210>  59
<211>  636
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pPE0496-Exendin-4 (9-39) ELP1-120 

<400>  59


Asp Leu Ser Lys Gln Met Glu Glu Glu Ala Val Arg Leu Phe Ile Glu 
1               5                   10                  15      


Trp Leu Lys Asn Gly Gly Pro Ser Ser Gly Ala Pro Pro Pro Ser Val 
            20                  25                  30          


Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro 
        35                  40                  45              


Gly Ala Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly 
    50                  55                  60                  


Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Gly 
65                  70                  75                  80  


Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly 
                85                  90                  95      


Val Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val 
            100                 105                 110         


Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro 
        115                 120                 125             


Gly Gly Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly 
    130                 135                 140                 


Gly Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro Gly Val 
145                 150                 155                 160 


Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly 
                165                 170                 175     


Val Pro Gly Gly Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val 
            180                 185                 190         


Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro 
        195                 200                 205             


Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly 
    210                 215                 220                 


Ala Gly Val Pro Gly Gly Gly Val Pro Gly Val Gly Val Pro Gly Val 
225                 230                 235                 240 


Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly 
                245                 250                 255     


Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val 
            260                 265                 270         


Pro Gly Ala Gly Val Pro Gly Gly Gly Val Pro Gly Val Gly Val Pro 
        275                 280                 285             


Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly 
    290                 295                 300                 


Val Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly 
305                 310                 315                 320 


Gly Val Pro Gly Ala Gly Val Pro Gly Gly Gly Val Pro Gly Val Gly 
                325                 330                 335     


Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val 
            340                 345                 350         


Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro 
        355                 360                 365             


Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Gly Gly Val Pro Gly 
    370                 375                 380                 


Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala 
385                 390                 395                 400 


Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Val Gly 
                405                 410                 415     


Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Gly Gly Val 
            420                 425                 430         


Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro 
        435                 440                 445             


Gly Ala Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly 
    450                 455                 460                 


Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Gly 
465                 470                 475                 480 


Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly 
                485                 490                 495     


Val Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val 
            500                 505                 510         


Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro 
        515                 520                 525             


Gly Gly Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly 
    530                 535                 540                 


Gly Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro Gly Val 
545                 550                 555                 560 


Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly 
                565                 570                 575     


Val Pro Gly Gly Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val 
            580                 585                 590         


Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro 
        595                 600                 605             


Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly 
    610                 615                 620                 


Ala Gly Val Pro Gly Gly Gly Val Pro Gly Trp Pro 
625                 630                 635 


<210>  60
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human recombinant Exendin-4 (9-30)

<400>  60

Asp Leu Ser Lys Gln Met Glu Glu Glu Ala Val Arg Leu Phe Ile Glu 
1               5                   10                  15      


Trp Leu Lys Asn Gly Gly 
            20          


<210>  61
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human recombinant M-Exendin-4 (9-31)

<400>  61

Met Asp Leu Ser Lys Gln Met Glu Glu Glu Ala Val Arg Leu Phe Ile 
1               5                   10                  15      


Glu Trp Leu Lys Asn Gly Gly Pro 
            20                  


<210>  62
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human recombinant M-Exendin-4 (9-39)

<400>  62

Met Asp Leu Ser Lys Gln Met Glu Glu Glu Ala Val Arg Leu Phe Ile 
1               5                   10                  15      


Glu Trp Leu Lys Asn Gly Gly Pro Ser Ser Gly Ala Pro Pro Pro Ser 
            20                  25                  30          


<210>  63
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human recombinant M-Exendin-4 (9-30)

<400>  63

Met Asp Leu Ser Lys Gln Met Glu Glu Glu Ala Val Arg Leu Phe Ile 
1               5                   10                  15      


Glu Trp Leu Lys Asn Gly Gly 
            20              


<210>  64
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human recombinant GLP-1 (9-29)

<400>  64

Asp Val Ser Ser Tyr Leu Glu Gly Gln Ala Ala Lys Glu Phe Ile Ala 
1               5                   10                  15      


Trp Leu Val Lys Gly 
            20      


<210>  65
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human recombinant GLP-1-exendin-4

<400>  65

Asp Val Ser Ser Tyr Leu Glu Gly Gln Ala Ala Lys Glu Phe Ile Ala 
1               5                   10                  15      


Trp Leu Val Lys Gly Arg Pro Ser Ser Gly Ala Pro Pro Pro Ser 
            20                  25                  30      


<210>  66
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human recombinant Jant-4 (9-30)

<400>  66

Asp Val Ser Ser Tyr Leu Glu Glu Gln Ala Val Arg Glu Phe Ile Ala 
1               5                   10                  15      


Trp Leu Val Lys Gly Arg 
            20          


<210>  67
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human recombinant Jant-4 (9-39)

<400>  67

Asp Val Ser Ser Tyr Leu Glu Glu Gln Ala Val Arg Glu Phe Ile Ala 
1               5                   10                  15      


Trp Leu Val Lys Gly Arg Pro Ser Ser Gly Ala Pro Pro Pro Ser 
            20                  25                  30      


<210>  68
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human recombinant GLP-2

<400>  68

His Ala Asp Gly Ser Phe Ser Asp Glu Met Asn Thr Ile Leu Asp Asn 
1               5                   10                  15      


Leu Ala Ala Arg Asp Phe Ile Asn Trp Leu Ile Gln Thr Lys Ile Thr 
            20                  25                  30          


Asp 
    


<210>  69
<211>  638
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pPE0527-GLP-2-ELP1-120

<400>  69

His Ala Asp Gly Ser Phe Ser Asp Glu Met Asn Thr Ile Leu Asp Asn 
1               5                   10                  15      


Leu Ala Ala Arg Asp Phe Ile Asn Trp Leu Ile Gln Thr Lys Ile Thr 
            20                  25                  30          


Asp Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly 
        35                  40                  45              


Val Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val 
    50                  55                  60                  


Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro 
65                  70                  75                  80  


Gly Gly Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly 
                85                  90                  95      


Gly Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro Gly Val 
            100                 105                 110         


Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly 
        115                 120                 125             


Val Pro Gly Gly Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val 
    130                 135                 140                 


Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro 
145                 150                 155                 160 


Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly 
                165                 170                 175     


Ala Gly Val Pro Gly Gly Gly Val Pro Gly Val Gly Val Pro Gly Val 
            180                 185                 190         


Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly 
        195                 200                 205             


Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val 
    210                 215                 220                 


Pro Gly Ala Gly Val Pro Gly Gly Gly Val Pro Gly Val Gly Val Pro 
225                 230                 235                 240 


Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly 
                245                 250                 255     


Val Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly 
            260                 265                 270         


Gly Val Pro Gly Ala Gly Val Pro Gly Gly Gly Val Pro Gly Val Gly 
        275                 280                 285             


Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val 
    290                 295                 300                 


Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro 
305                 310                 315                 320 


Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Gly Gly Val Pro Gly 
                325                 330                 335     


Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala 
            340                 345                 350         


Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Val Gly 
        355                 360                 365             


Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Gly Gly Val 
    370                 375                 380                 


Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro 
385                 390                 395                 400 


Gly Ala Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly 
                405                 410                 415     


Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Gly 
            420                 425                 430         


Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly 
        435                 440                 445             


Val Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val 
    450                 455                 460                 


Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro 
465                 470                 475                 480 


Gly Gly Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly 
                485                 490                 495     


Gly Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro Gly Val 
            500                 505                 510         


Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly 
        515                 520                 525             


Val Pro Gly Gly Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val 
    530                 535                 540                 


Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro 
545                 550                 555                 560 


Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly 
                565                 570                 575     


Ala Gly Val Pro Gly Gly Gly Val Pro Gly Val Gly Val Pro Gly Val 
            580                 585                 590         


Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly 
        595                 600                 605             


Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val 
    610                 615                 620                 


Pro Gly Ala Gly Val Pro Gly Gly Gly Val Pro Gly Trp Pro 
625                 630                 635                     


<210>  70
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human recombinant GLP-2(A2G)

<400>  70

His Gly Asp Gly Ser Phe Ser Asp Glu Met Asn Thr Ile Leu Asp Asn 
1               5                   10                  15      


Leu Ala Ala Arg Asp Phe Ile Asn Trp Leu Ile Gln Thr Lys Ile Thr 
            20                  25                  30          


Asp 
    


<210>  71
<211>  638
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pPE0503-GLP-2(A2G)-ELP1-120

<400>  71

His Gly Asp Gly Ser Phe Ser Asp Glu Met Asn Thr Ile Leu Asp Asn 
1               5                   10                  15      


Leu Ala Ala Arg Asp Phe Ile Asn Trp Leu Ile Gln Thr Lys Ile Thr 
            20                  25                  30          


Asp Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly 
        35                  40                  45              


Val Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val 
    50                  55                  60                  


Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro 
65                  70                  75                  80  


Gly Gly Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly 
                85                  90                  95      


Gly Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro Gly Val 
            100                 105                 110         


Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly 
        115                 120                 125             


Val Pro Gly Gly Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val 
    130                 135                 140                 


Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro 
145                 150                 155                 160 


Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly 
                165                 170                 175     


Ala Gly Val Pro Gly Gly Gly Val Pro Gly Val Gly Val Pro Gly Val 
            180                 185                 190         


Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly 
        195                 200                 205             


Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val 
    210                 215                 220                 


Pro Gly Ala Gly Val Pro Gly Gly Gly Val Pro Gly Val Gly Val Pro 
225                 230                 235                 240 


Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly 
                245                 250                 255     


Val Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly 
            260                 265                 270         


Gly Val Pro Gly Ala Gly Val Pro Gly Gly Gly Val Pro Gly Val Gly 
        275                 280                 285             


Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val 
    290                 295                 300                 


Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro 
305                 310                 315                 320 


Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Gly Gly Val Pro Gly 
                325                 330                 335     


Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala 
            340                 345                 350         


Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Val Gly 
        355                 360                 365             


Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Gly Gly Val 
    370                 375                 380                 


Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro 
385                 390                 395                 400 


Gly Ala Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly 
                405                 410                 415     


Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Gly 
            420                 425                 430         


Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly 
        435                 440                 445             


Val Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val 
    450                 455                 460                 


Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro 
465                 470                 475                 480 


Gly Gly Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly 
                485                 490                 495     


Gly Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro Gly Val 
            500                 505                 510         


Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly 
        515                 520                 525             


Val Pro Gly Gly Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val 
    530                 535                 540                 


Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro 
545                 550                 555                 560 


Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly 
                565                 570                 575     


Ala Gly Val Pro Gly Gly Gly Val Pro Gly Val Gly Val Pro Gly Val 
            580                 585                 590         


Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly 
        595                 600                 605             


Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val 
    610                 615                 620                 


Pro Gly Ala Gly Val Pro Gly Gly Gly Val Pro Gly Trp Pro 
625                 630                 635             


<210>  72
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human recombinant GLP-2(A2G)-(GGS)2x linker

<400>  72

His Gly Asp Gly Ser Phe Ser Asp Glu Met Asn Thr Ile Leu Asp Asn 
1               5                   10                  15      


Leu Ala Ala Arg Asp Phe Ile Asn Trp Leu Ile Gln Thr Lys Ile Thr 
            20                  25                  30          


Asp Gly Gly Ser Gly Gly Ser 
        35                  


<210>  73
<211>  644
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pPE0526 GLP-2(A2G)-(GGS)2x linker  ELP1-120

<400>  73

His Gly Asp Gly Ser Phe Ser Asp Glu Met Asn Thr Ile Leu Asp Asn 
1               5                   10                  15      


Leu Ala Ala Arg Asp Phe Ile Asn Trp Leu Ile Gln Thr Lys Ile Thr 
            20                  25                  30          


Asp Gly Gly Ser Gly Gly Ser Val Pro Gly Val Gly Val Pro Gly Val 
        35                  40                  45              


Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly 
    50                  55                  60                  


Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val 
65                  70                  75                  80  


Pro Gly Ala Gly Val Pro Gly Gly Gly Val Pro Gly Val Gly Val Pro 
                85                  90                  95      


Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly 
            100                 105                 110         


Val Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly 
        115                 120                 125             


Gly Val Pro Gly Ala Gly Val Pro Gly Gly Gly Val Pro Gly Val Gly 
    130                 135                 140                 


Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val 
145                 150                 155                 160 


Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro 
                165                 170                 175     


Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Gly Gly Val Pro Gly 
            180                 185                 190         


Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala 
        195                 200                 205             


Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Val Gly 
    210                 215                 220                 


Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Gly Gly Val 
225                 230                 235                 240 


Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro 
                245                 250                 255     


Gly Ala Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly 
            260                 265                 270         


Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Gly 
        275                 280                 285             


Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly 
    290                 295                 300                 


Val Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val 
305                 310                 315                 320 


Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro 
                325                 330                 335     


Gly Gly Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly 
            340                 345                 350         


Gly Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro Gly Val 
        355                 360                 365             


Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly 
    370                 375                 380                 


Val Pro Gly Gly Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val 
385                 390                 395                 400 


Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro 
                405                 410                 415     


Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly 
            420                 425                 430         


Ala Gly Val Pro Gly Gly Gly Val Pro Gly Val Gly Val Pro Gly Val 
        435                 440                 445             


Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly 
    450                 455                 460                 


Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val 
465                 470                 475                 480 


Pro Gly Ala Gly Val Pro Gly Gly Gly Val Pro Gly Val Gly Val Pro 
                485                 490                 495     


Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly 
            500                 505                 510         


Val Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly 
        515                 520                 525             


Gly Val Pro Gly Ala Gly Val Pro Gly Gly Gly Val Pro Gly Val Gly 
    530                 535                 540                 


Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val 
545                 550                 555                 560 


Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro 
                565                 570                 575     


Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Gly Gly Val Pro Gly 
            580                 585                 590         


Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala 
        595                 600                 605             


Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Val Gly 
    610                 615                 620                 


Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Gly Gly Val 
625                 630                 635                 640 


Pro Gly Trp Pro 
                

<210>  74
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human recombinant GLP-2-consensus


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa may be Ala, Gly, Leu, Ile or Val

<400>  74

His Xaa Asp Gly Ser Phe Ser Asp Glu Met Asn Thr Ile Leu Asp Asn 
1               5                   10                  15      


Leu Ala Ala Arg Asp Phe Ile Asn Trp Leu Ile Gln Thr Lys Ile Thr 
            20                  25                  30          


Asp 
    


<210>  75
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human recombinant hepcidin

<400>  75

Asp Thr His Phe Pro Ile Cys Ile Phe Cys Cys Gly Cys Cys His Arg 
1               5                   10                  15      


Ser Lys Cys Gly Met Cys Cys Lys Thr 
            20                  25  


<210>  76
<211>  631
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pPE0479 ELP1-120 hepcidin

<400>  76

Met Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly 
1               5                   10                  15      


Val Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val 
            20                  25                  30          


Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro 
        35                  40                  45              


Gly Gly Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly 
    50                  55                  60                  


Gly Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro Gly Val 
65                  70                  75                  80  


Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly 
                85                  90                  95      


Val Pro Gly Gly Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val 
            100                 105                 110         


Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro 
        115                 120                 125             


Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly 
    130                 135                 140                 


Ala Gly Val Pro Gly Gly Gly Val Pro Gly Val Gly Val Pro Gly Val 
145                 150                 155                 160 


Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly 
                165                 170                 175     


Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val 
            180                 185                 190         


Pro Gly Ala Gly Val Pro Gly Gly Gly Val Pro Gly Val Gly Val Pro 
        195                 200                 205             


Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly 
    210                 215                 220                 


Val Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly 
225                 230                 235                 240 


Gly Val Pro Gly Ala Gly Val Pro Gly Gly Gly Val Pro Gly Val Gly 
                245                 250                 255     


Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val 
            260                 265                 270         


Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro 
        275                 280                 285             


Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Gly Gly Val Pro Gly 
    290                 295                 300                 


Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala 
305                 310                 315                 320 


Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Val Gly 
                325                 330                 335     


Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Gly Gly Val 
            340                 345                 350         


Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro 
        355                 360                 365             


Gly Ala Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly 
    370                 375                 380                 


Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Gly 
385                 390                 395                 400 


Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly 
                405                 410                 415     


Val Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val 
            420                 425                 430         


Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro 
        435                 440                 445             


Gly Gly Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly 
    450                 455                 460                 


Gly Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro Gly Val 
465                 470                 475                 480 


Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly 
                485                 490                 495     


Val Pro Gly Gly Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val 
            500                 505                 510         


Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro 
        515                 520                 525             


Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly 
    530                 535                 540                 


Ala Gly Val Pro Gly Gly Gly Val Pro Gly Val Gly Val Pro Gly Val 
545                 550                 555                 560 


Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly 
                565                 570                 575     


Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val 
            580                 585                 590         


Pro Gly Ala Gly Val Pro Gly Gly Gly Val Pro Trp Val Gly Asp Thr 
        595                 600                 605             


His Phe Pro Ile Cys Ile Phe Cys Cys Gly Cys Cys His Arg Ser Lys 
    610                 615                 620                 


Cys Gly Met Cys Cys Lys Thr 
625                 630     


<210>  77
<211>  630
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pPE0487 hepcidin ELP1-120

<400>  77

Asp Thr His Phe Pro Ile Cys Ile Phe Cys Cys Gly Cys Cys His Arg 
1               5                   10                  15      


Ser Lys Cys Gly Met Cys Cys Lys Thr Val Pro Gly Val Gly Val Pro 
            20                  25                  30          


Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly 
        35                  40                  45              


Val Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly 
    50                  55                  60                  


Gly Val Pro Gly Ala Gly Val Pro Gly Gly Gly Val Pro Gly Val Gly 
65                  70                  75                  80  


Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val 
                85                  90                  95      


Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro 
            100                 105                 110         


Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Gly Gly Val Pro Gly 
        115                 120                 125             


Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala 
    130                 135                 140                 


Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Val Gly 
145                 150                 155                 160 


Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Gly Gly Val 
                165                 170                 175     


Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro 
            180                 185                 190         


Gly Ala Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly 
        195                 200                 205             


Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Gly 
    210                 215                 220                 


Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly 
225                 230                 235                 240 


Val Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val 
                245                 250                 255     


Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro 
            260                 265                 270         


Gly Gly Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly 
        275                 280                 285             


Gly Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro Gly Val 
    290                 295                 300                 


Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly 
305                 310                 315                 320 


Val Pro Gly Gly Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val 
                325                 330                 335     


Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro 
            340                 345                 350         


Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly 
        355                 360                 365             


Ala Gly Val Pro Gly Gly Gly Val Pro Gly Val Gly Val Pro Gly Val 
    370                 375                 380                 


Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly 
385                 390                 395                 400 


Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val 
                405                 410                 415     


Pro Gly Ala Gly Val Pro Gly Gly Gly Val Pro Gly Val Gly Val Pro 
            420                 425                 430         


Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly 
        435                 440                 445             


Val Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly 
    450                 455                 460                 


Gly Val Pro Gly Ala Gly Val Pro Gly Gly Gly Val Pro Gly Val Gly 
465                 470                 475                 480 


Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val 
                485                 490                 495     


Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro 
            500                 505                 510         


Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Gly Gly Val Pro Gly 
        515                 520                 525             


Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala 
    530                 535                 540                 


Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Val Gly 
545                 550                 555                 560 


Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Gly Gly Val 
                565                 570                 575     


Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro 
            580                 585                 590         


Gly Ala Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly 
        595                 600                 605             


Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Gly 
    610                 615                 620                 


Gly Val Pro Gly Trp Pro 
625                 630 



<210>  78
<211>  70
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human recombinant IGF-1

<400>  78

Gly Pro Glu Thr Leu Cys Gly Ala Glu Leu Val Asp Ala Leu Gln Phe 
1               5                   10                  15      


Val Cys Gly Asp Arg Gly Phe Tyr Phe Asn Lys Pro Thr Gly Tyr Gly 
            20                  25                  30          


Ser Ser Ser Arg Arg Ala Pro Gln Thr Gly Ile Val Asp Glu Cys Cys 
        35                  40                  45              


Phe Arg Ser Cys Asp Leu Arg Arg Leu Glu Met Tyr Cys Ala Pro Leu 
    50                  55                  60                  


Lys Pro Ala Lys Ser Ala 
65                  70  


<210>  79
<211>  675
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pPE0410 IGF-1 ELP1-120

<400>  79

Gly Pro Glu Thr Leu Cys Gly Ala Glu Leu Val Asp Ala Leu Gln Phe 
1               5                   10                  15      


Val Cys Gly Asp Arg Gly Phe Tyr Phe Asn Lys Pro Thr Gly Tyr Gly 
            20                  25                  30          


Ser Ser Ser Arg Arg Ala Pro Gln Thr Gly Ile Val Asp Glu Cys Cys 
        35                  40                  45              


Phe Arg Ser Cys Asp Leu Arg Arg Leu Glu Met Tyr Cys Ala Pro Leu 
    50                  55                  60                  


Lys Pro Ala Lys Ser Ala Val Pro Gly Val Gly Val Pro Gly Val Gly 
65                  70                  75                  80  


Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly Val 
                85                  90                  95      


Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro 
            100                 105                 110         


Gly Ala Gly Val Pro Gly Gly Gly Val Pro Gly Val Gly Val Pro Gly 
        115                 120                 125             


Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Val 
    130                 135                 140                 


Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly 
145                 150                 155                 160 


Val Pro Gly Ala Gly Val Pro Gly Gly Gly Val Pro Gly Val Gly Val 
                165                 170                 175     


Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro 
            180                 185                 190         


Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly 
        195                 200                 205             


Gly Gly Val Pro Gly Ala Gly Val Pro Gly Gly Gly Val Pro Gly Val 
    210                 215                 220                 


Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly 
225                 230                 235                 240 


Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val 
                245                 250                 255     


Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Gly Gly Val Pro 
            260                 265                 270         


Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly 
        275                 280                 285             


Ala Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Val 
    290                 295                 300                 


Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Gly Gly 
305                 310                 315                 320 


Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val 
                325                 330                 335     


Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro 
            340                 345                 350         


Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly 
        355                 360                 365             


Gly Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly 
    370                 375                 380                 


Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro Gly Val Gly 
385                 390                 395                 400 


Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val 
                405                 410                 415     


Pro Gly Gly Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro 
            420                 425                 430         


Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro Gly 
        435                 440                 445             


Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala 
    450                 455                 460                 


Gly Val Pro Gly Gly Gly Val Pro Gly Val Gly Val Pro Gly Val Gly 
465                 470                 475                 480 


Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly Val 
                485                 490                 495     


Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro 
            500                 505                 510         


Gly Ala Gly Val Pro Gly Gly Gly Val Pro Gly Val Gly Val Pro Gly 
        515                 520                 525             


Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Val 
    530                 535                 540                 


Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly 
545                 550                 555                 560 


Val Pro Gly Ala Gly Val Pro Gly Gly Gly Val Pro Gly Val Gly Val 
                565                 570                 575     


Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro 
            580                 585                 590         


Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly 
        595                 600                 605             


Gly Gly Val Pro Gly Ala Gly Val Pro Gly Gly Gly Val Pro Gly Val 
    610                 615                 620                 


Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly 
625                 630                 635                 640 


Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val 
                645                 650                 655     


Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Gly Gly Val Pro 
            660                 665                 670         


Gly Trp Pro 
        675 




<210>  80
<211>  800
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pPE0413 IGF-1 ELPbetav2 144mer

<400>  80

Gly Pro Glu Thr Leu Cys Gly Ala Glu Leu Val Asp Ala Leu Gln Phe 
1               5                   10                  15      


Val Cys Gly Asp Arg Gly Phe Tyr Phe Asn Lys Pro Thr Gly Tyr Gly 
            20                  25                  30          


Ser Ser Ser Arg Arg Ala Pro Gln Thr Gly Ile Val Asp Glu Cys Cys 
        35                  40                  45              


Phe Arg Ser Cys Asp Leu Arg Arg Leu Glu Met Tyr Cys Ala Pro Leu 
    50                  55                  60                  


Lys Pro Ala Lys Ser Ala Val Pro Gly Val Gly Val Pro Gly Val Gly 
65                  70                  75                  80  


Val Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro Gly Ala Gly Val 
                85                  90                  95      


Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Ala Gly Val Pro 
            100                 105                 110         


Gly Val Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro Gly 
        115                 120                 125             


Ala Gly Val Pro Gly Val Gly Val Pro Gly Ala Gly Val Pro Gly Val 
    130                 135                 140                 


Gly Val Pro Gly Val Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly 
145                 150                 155                 160 


Val Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro Gly Ala Gly Val 
                165                 170                 175     


Pro Gly Val Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro 
            180                 185                 190         


Gly Val Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro Gly 
        195                 200                 205             


Ala Gly Val Pro Gly Val Gly Val Pro Gly Ala Gly Val Pro Gly Val 
    210                 215                 220                 


Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro Gly Val Gly 
225                 230                 235                 240 


Val Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro Gly Ala Gly Val 
                245                 250                 255     


Pro Gly Val Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro 
            260                 265                 270         


Gly Ala Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly 
        275                 280                 285             


Ala Gly Val Pro Gly Val Gly Val Pro Gly Ala Gly Val Pro Gly Val 
    290                 295                 300                 


Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro Gly Ala Gly 
305                 310                 315                 320 


Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Ala Gly Val 
                325                 330                 335     


Pro Gly Val Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro 
            340                 345                 350         


Gly Ala Gly Val Pro Gly Val Gly Val Pro Gly Ala Gly Val Pro Gly 
        355                 360                 365             


Val Gly Val Pro Gly Val Gly Val Pro Gly Ala Gly Val Pro Gly Val 
    370                 375                 380                 


Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro Gly Ala Gly 
385                 390                 395                 400 


Val Pro Gly Val Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly Val 
                405                 410                 415     


Pro Gly Val Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro 
            420                 425                 430         


Gly Ala Gly Val Pro Gly Val Gly Val Pro Gly Ala Gly Val Pro Gly 
        435                 440                 445             


Val Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro Gly Val 
    450                 455                 460                 


Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro Gly Ala Gly 
465                 470                 475                 480 


Val Pro Gly Val Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly Val 
                485                 490                 495     


Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro 
            500                 505                 510         


Gly Ala Gly Val Pro Gly Val Gly Val Pro Gly Ala Gly Val Pro Gly 
        515                 520                 525             


Val Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro Gly Ala 
    530                 535                 540                 


Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Ala Gly 
545                 550                 555                 560 


Val Pro Gly Val Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly Val 
                565                 570                 575     


Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro Gly Ala Gly Val Pro 
            580                 585                 590         


Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Ala Gly Val Pro Gly 
        595                 600                 605             


Val Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro Gly Ala 
    610                 615                 620                 


Gly Val Pro Gly Val Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly 
625                 630                 635                 640 


Val Pro Gly Val Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly Val 
                645                 650                 655     


Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro Gly Ala Gly Val Pro 
            660                 665                 670         


Gly Val Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro Gly 
        675                 680                 685             


Val Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro Gly Ala 
    690                 695                 700                 


Gly Val Pro Gly Val Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly 
705                 710                 715                 720 


Val Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val 
                725                 730                 735     


Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro Gly Ala Gly Val Pro 
            740                 745                 750         


Gly Val Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro Gly 
        755                 760                 765             


Ala Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Ala 
    770                 775                 780                 


Gly Val Pro Gly Val Gly Val Pro Gly Ala Gly Val Pro Gly Trp Pro 
785                 790                 795                 800 


<210>  81
<211>  1935
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ELP1-120 CNP37 fusion

<400>  81
atggtaccgg gcgtgggtgt tccgggcgtg ggtgttccgg gtggcggtgt gccgggcgca       60

ggtgttcctg gtgtaggtgt gccgggtgtt ggtgtgccgg gtgttggtgt accaggtggc      120

ggtgttccgg gtgcaggcgt tccgggtggc ggtgtgccgg gcgtgggtgt tccgggcgtg      180

ggtgttccgg gtggcggtgt gccgggcgca ggtgttcctg gtgtaggtgt gccgggtgtt      240

ggtgtgccgg gtgttggtgt accaggtggc ggtgttccgg gtgcaggcgt tccgggtggc      300

ggtgtgccgg gcgtgggtgt tccgggcgtg ggtgttccgg gtggcggtgt gccgggcgca      360

ggtgttcctg gtgtaggtgt gccgggtgtt ggtgtgccgg gtgttggtgt accaggtggc      420

ggtgttccgg gtgcaggcgt tccgggtggc ggtgtgccgg gcgtgggtgt tccgggcgtg      480

ggtgttccgg gtggcggtgt gccgggcgca ggtgttcctg gtgtaggtgt gccgggtgtt      540

ggtgtgccgg gtgttggtgt accaggtggc ggtgttccgg gtgcaggcgt tccgggtggc      600

ggtgtgccgg gcgtgggtgt tccgggcgtg ggtgttccgg gtggcggtgt gccgggcgca      660

ggtgttcctg gtgtaggtgt gccgggtgtt ggtgtgccgg gtgttggtgt accaggtggc      720

ggtgttccgg gtgcaggcgt tccgggtggc ggtgtgccgg gcgtgggtgt tccgggcgtg      780

ggtgttccgg gtggcggtgt gccgggcgca ggtgttcctg gtgtaggtgt gccgggtgtt      840

ggtgtgccgg gtgttggtgt accaggtggc ggtgttccgg gtgcaggcgt tccgggtggc      900

ggtgtgccgg gcgtgggtgt tccgggcgtg ggtgttccgg gtggcggtgt gccgggcgca      960

ggtgttcctg gtgtaggtgt gccgggtgtt ggtgtgccgg gtgttggtgt accaggtggc     1020

ggtgttccgg gtgcaggcgt tccgggtggc ggtgtgccgg gcgtgggtgt tccgggcgtg     1080

ggtgttccgg gtggcggtgt gccgggcgca ggtgttcctg gtgtaggtgt gccgggtgtt     1140

ggtgtgccgg gtgttggtgt accaggtggc ggtgttccgg gtgcaggcgt tccgggtggc     1200

ggtgtgccgg gcgtgggtgt tccgggcgtg ggtgttccgg gtggcggtgt gccgggcgca     1260

ggtgttcctg gtgtaggtgt gccgggtgtt ggtgtgccgg gtgttggtgt accaggtggc     1320

ggtgttccgg gtgcaggcgt tccgggtggc ggtgtgccgg gcgtgggtgt tccgggcgtg     1380

ggtgttccgg gtggcggtgt gccgggcgca ggtgttcctg gtgtaggtgt gccgggtgtt     1440

ggtgtgccgg gtgttggtgt accaggtggc ggtgttccgg gtgcaggcgt tccgggtggc     1500

ggtgtgccgg gcgtgggtgt tccgggcgtg ggtgttccgg gtggcggtgt gccgggcgca     1560

ggtgttcctg gtgtaggtgt gccgggtgtt ggtgtgccgg gtgttggtgt accaggtggc     1620

ggtgttccgg gtgcaggcgt tccgggtggc ggtgtgccgg gcgtgggtgt tccgggcgtg     1680

ggtgttccgg gtggcggtgt gccgggcgca ggtgttcctg gtgtaggtgt gccgggtgtt     1740

ggtgtgccgg gtgttggtgt accaggtggc ggtgttccgg gtgcaggcgt tccgggtggc     1800

ggtgtgccgg gcgtggggca ggaacatccg aacgcgcgta aatataaagg tgcgaacaaa     1860

aaaggcctga gcaaaggctg ctttggcctg aaactggatc gcattggcag catgagcggc     1920

ctgggctgct gataa   1935


<210>  82
<211>  1935
<212>  DNA
<213>  Artificial Sequence 

<220>
<223>  CNP37 ELP1-120 fusion

<400>  82
caggaacatc cgaacgcgcg taaatataaa ggtgcgaaca aaaaaggcct gagcaaaggc       60

tgctttggcc tgaaactgga tcgcattggc agcatgagcg gcctgggctg cggtgtaccg      120

ggcgtgggtg ttccgggcgt gggtgttccg ggtggcggtg tgccgggcgc aggtgttcct      180

ggtgtaggtg tgccgggtgt tggtgtgccg ggtgttggtg taccaggtgg cggtgttccg      240

ggtgcaggcg ttccgggtgg cggtgtgccg ggcgtgggtg ttccgggcgt gggtgttccg      300

ggtggcggtg tgccgggcgc aggtgttcct ggtgtaggtg tgccgggtgt tggtgtgccg      360

ggtgttggtg taccaggtgg cggtgttccg ggtgcaggcg ttccgggtgg cggtgtgccg      420

ggcgtgggtg ttccgggcgt gggtgttccg ggtggcggtg tgccgggcgc aggtgttcct      480

ggtgtaggtg tgccgggtgt tggtgtgccg ggtgttggtg taccaggtgg cggtgttccg      540

ggtgcaggcg ttccgggtgg cggtgtgccg ggcgtgggtg ttccgggcgt gggtgttccg      600

ggtggcggtg tgccgggcgc aggtgttcct ggtgtaggtg tgccgggtgt tggtgtgccg      660

ggtgttggtg taccaggtgg cggtgttccg ggtgcaggcg ttccgggtgg cggtgtgccg      720

ggcgtgggtg ttccgggcgt gggtgttccg ggtggcggtg tgccgggcgc aggtgttcct      780

ggtgtaggtg tgccgggtgt tggtgtgccg ggtgttggtg taccaggtgg cggtgttccg      840

ggtgcaggcg ttccgggtgg cggtgtgccg ggcgtgggtg ttccgggcgt gggtgttccg      900

ggtggcggtg tgccgggcgc aggtgttcct ggtgtaggtg tgccgggtgt tggtgtgccg      960

ggtgttggtg taccaggtgg cggtgttccg ggtgcaggcg ttccgggtgg cggtgtgccg     1020

ggcgtgggtg ttccgggcgt gggtgttccg ggtggcggtg tgccgggcgc aggtgttcct     1080

ggtgtaggtg tgccgggtgt tggtgtgccg ggtgttggtg taccaggtgg cggtgttccg     1140

ggtgcaggcg ttccgggtgg cggtgtgccg ggcgtgggtg ttccgggcgt gggtgttccg     1200

ggtggcggtg tgccgggcgc aggtgttcct ggtgtaggtg tgccgggtgt tggtgtgccg     1260

ggtgttggtg taccaggtgg cggtgttccg ggtgcaggcg ttccgggtgg cggtgtgccg     1320

ggcgtgggtg ttccgggcgt gggtgttccg ggtggcggtg tgccgggcgc aggtgttcct     1380

ggtgtaggtg tgccgggtgt tggtgtgccg ggtgttggtg taccaggtgg cggtgttccg     1440

ggtgcaggcg ttccgggtgg cggtgtgccg ggcgtgggtg ttccgggcgt gggtgttccg     1500

ggtggcggtg tgccgggcgc aggtgttcct ggtgtaggtg tgccgggtgt tggtgtgccg     1560

ggtgttggtg taccaggtgg cggtgttccg ggtgcaggcg ttccgggtgg cggtgtgccg     1620

ggcgtgggtg ttccgggcgt gggtgttccg ggtggcggtg tgccgggcgc aggtgttcct     1680

ggtgtaggtg tgccgggtgt tggtgtgccg ggtgttggtg taccaggtgg cggtgttccg     1740

ggtgcaggcg ttccgggtgg cggtgtgccg ggcgtgggtg ttccgggcgt gggtgttccg     1800

ggtggcggtg tgccgggcgc aggtgttcct ggtgtaggtg tgccgggtgt tggtgtgccg     1860

ggtgttggtg taccaggtgg cggtgttccg ggtgcaggcg ttccgggtgg cggtgtgccg     1920

ggctggccgt gataa  1935


<210>  83
<211>  648
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CNP37 GGS2x ELP1-120 fusion 

<400>  83

Gln Glu His Pro Asn Ala Arg Lys Tyr Lys Gly Ala Asn Lys Lys Gly 
1               5                   10                  15      


Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser Met 
            20                  25                  30          


Ser Gly Leu Gly Cys Gly Gly Ser Gly Gly Ser Val Pro Gly Val Gly 
        35                  40                  45              


Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val 
    50                  55                  60                  


Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro 
65                  70                  75                  80  


Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Gly Gly Val Pro Gly 
                85                  90                  95      


Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala 
            100                 105                 110         


Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Val Gly 
        115                 120                 125             


Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Gly Gly Val 
    130                 135                 140                 


Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro 
145                 150                 155                 160 


Gly Ala Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly 
                165                 170                 175     


Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Gly 
            180                 185                 190         


Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly 
        195                 200                 205             


Val Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val 
    210                 215                 220                 


Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro 
225                 230                 235                 240 


Gly Gly Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly 
                245                 250                 255     


Gly Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro Gly Val 
            260                 265                 270         


Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly 
        275                 280                 285             


Val Pro Gly Gly Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val 
    290                 295                 300                 


Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro 
305                 310                 315                 320 


Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly 
                325                 330                 335     


Ala Gly Val Pro Gly Gly Gly Val Pro Gly Val Gly Val Pro Gly Val 
            340                 345                 350         


Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly 
        355                 360                 365             


Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val 
    370                 375                 380                 


Pro Gly Ala Gly Val Pro Gly Gly Gly Val Pro Gly Val Gly Val Pro 
385                 390                 395                 400 


Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly 
                405                 410                 415     


Val Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly 
            420                 425                 430         


Gly Val Pro Gly Ala Gly Val Pro Gly Gly Gly Val Pro Gly Val Gly 
        435                 440                 445             


Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val 
    450                 455                 460                 


Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro 
465                 470                 475                 480 


Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Gly Gly Val Pro Gly 
                485                 490                 495     


Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala 
            500                 505                 510         


Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Val Gly 
        515                 520                 525             


Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Gly Gly Val 
    530                 535                 540                 


Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro 
545                 550                 555                 560 


Gly Ala Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly 
                565                 570                 575     


Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Gly 
            580                 585                 590         


Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly 
        595                 600                 605             


Val Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val 
    610                 615                 620                 


Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro 
625                 630                 635                 640 


Gly Gly Gly Val Pro Gly Trp Pro 
                645             

<210>  84
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human recombinant urodilatin

<400>  84

Thr Ala Pro Arg Ser Leu Arg Arg Ser Ser Cys Phe Gly Gly Arg Met 
1               5                   10                  15      


Asp Arg Ile Gly Ala Gln Ser Gly Leu Gly Cys Asn Ser Phe Arg Tyr 
            20                  25                  30          


<210>  85
<211>  637
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pPE0483 urodilatin ELP1-120

<400>  85


Thr Ala Pro Arg Ser Leu Arg Arg Ser Ser Cys Phe Gly Gly Arg Met 
1               5                   10                  15      


Asp Arg Ile Gly Ala Gln Ser Gly Leu Gly Cys Asn Ser Phe Arg Tyr 
            20                  25                  30          


Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val 
        35                  40                  45              


Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro 
    50                  55                  60                  


Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly 
65                  70                  75                  80  


Gly Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly 
                85                  90                  95      


Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro Gly Val Gly 
            100                 105                 110         


Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val 
        115                 120                 125             


Pro Gly Gly Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro 
    130                 135                 140                 


Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro Gly 
145                 150                 155                 160 


Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala 
                165                 170                 175     


Gly Val Pro Gly Gly Gly Val Pro Gly Val Gly Val Pro Gly Val Gly 
            180                 185                 190         


Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly Val 
        195                 200                 205             


Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro 
    210                 215                 220                 


Gly Ala Gly Val Pro Gly Gly Gly Val Pro Gly Val Gly Val Pro Gly 
225                 230                 235                 240 


Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Val 
                245                 250                 255     


Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly 
            260                 265                 270         


Val Pro Gly Ala Gly Val Pro Gly Gly Gly Val Pro Gly Val Gly Val 
        275                 280                 285             


Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro 
    290                 295                 300                 


Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly 
305                 310                 315                 320 


Gly Gly Val Pro Gly Ala Gly Val Pro Gly Gly Gly Val Pro Gly Val 
                325                 330                 335     


Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly 
            340                 345                 350         


Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val 
        355                 360                 365             


Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Gly Gly Val Pro 
    370                 375                 380                 


Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly 
385                 390                 395                 400 


Ala Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Val 
                405                 410                 415     


Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Gly Gly 
            420                 425                 430         


Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val 
        435                 440                 445             


Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro 
    450                 455                 460                 


Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly 
465                 470                 475                 480 


Gly Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly 
                485                 490                 495     


Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro Gly Val Gly 
            500                 505                 510         


Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val 
        515                 520                 525             


Pro Gly Gly Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro 
    530                 535                 540                 


Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro Gly 
545                 550                 555                 560 


Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala 
                565                 570                 575     


Gly Val Pro Gly Gly Gly Val Pro Gly Val Gly Val Pro Gly Val Gly 
            580                 585                 590         


Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly Val 
        595                 600                 605             


Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro 
    610                 615                 620                 


Gly Ala Gly Val Pro Gly Gly Gly Val Pro Gly Trp Pro 
625                 630                 635         

       


<210>  86
<211>  638
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pPE0484 ELP1-120 urodilatin

<400>  86

Met Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly 
1               5                   10                  15      


Val Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val 
            20                  25                  30          


Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro 
        35                  40                  45              


Gly Gly Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly 
    50                  55                  60                  


Gly Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro Gly Val 
65                  70                  75                  80  


Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly 
                85                  90                  95      


Val Pro Gly Gly Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val 
            100                 105                 110         


Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro 
        115                 120                 125             


Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly 
    130                 135                 140                 


Ala Gly Val Pro Gly Gly Gly Val Pro Gly Val Gly Val Pro Gly Val 
145                 150                 155                 160 


Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly 
                165                 170                 175     


Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val 
            180                 185                 190         


Pro Gly Ala Gly Val Pro Gly Gly Gly Val Pro Gly Val Gly Val Pro 
        195                 200                 205             


Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly 
    210                 215                 220                 


Val Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly 
225                 230                 235                 240 


Gly Val Pro Gly Ala Gly Val Pro Gly Gly Gly Val Pro Gly Val Gly 
                245                 250                 255     


Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val 
            260                 265                 270         


Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro 
        275                 280                 285             


Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Gly Gly Val Pro Gly 
    290                 295                 300                 


Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala 
305                 310                 315                 320 


Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Val Gly 
                325                 330                 335     


Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Gly Gly Val 
            340                 345                 350         


Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro 
        355                 360                 365             


Gly Ala Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly 
    370                 375                 380                 


Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Gly 
385                 390                 395                 400 


Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly 
                405                 410                 415     


Val Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val 
            420                 425                 430         


Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro 
        435                 440                 445             


Gly Gly Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly 
    450                 455                 460                 


Gly Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro Gly Val 
465                 470                 475                 480 


Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly 
                485                 490                 495     


Val Pro Gly Gly Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val 
            500                 505                 510         


Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro 
        515                 520                 525             


Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly 
    530                 535                 540                 


Ala Gly Val Pro Gly Gly Gly Val Pro Gly Val Gly Val Pro Gly Val 
545                 550                 555                 560 


Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly 
                565                 570                 575     


Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val 
            580                 585                 590         


Pro Gly Ala Gly Val Pro Gly Gly Gly Val Pro Gly Trp Gly Thr Ala 
        595                 600                 605             


Pro Arg Ser Leu Arg Arg Ser Ser Cys Phe Gly Gly Arg Met Asp Arg 
    610                 615                 620                 


Ile Gly Ala Gln Ser Gly Leu Gly Cys Asn Ser Phe Arg Tyr 
625                 630                 635             


            

<210>  87
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GGS tripeptide

<400>  87

Gly Gly Ser 
1           


<210>  88
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hepcidin (1-9)

<400>  88

Asp Thr His Phe Pro Ile Cys Ile Phe 
1               5                   


<210>  89
<211>  43
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Thymosin beta 4

<400>  89

Ser Asp Lys Pro Asp Met Ala Glu Ile Glu Lys Phe Asp Lys Ser Lys 
1               5                   10                  15      


Leu Lys Lys Thr Glu Thr Gln Glu Lys Asn Pro Leu Pro Ser Lys Glu 
            20                  25                  30          


Thr Ile Glu Gln Glu Lys Gln Ala Gly Glu Ser 
        35                  40              


<210>  90
<211>  648
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pPE0320 thymosin beta 4 ELP1-120

<400>  90

Ser Asp Lys Pro Asp Met Ala Glu Ile Glu Lys Phe Asp Lys Ser Lys 
1               5                   10                  15      


Leu Lys Lys Thr Glu Thr Gln Glu Lys Asn Pro Leu Pro Ser Lys Glu 
            20                  25                  30          


Thr Ile Glu Gln Glu Lys Gln Ala Gly Glu Ser Val Pro Gly Val Gly 
        35                  40                  45              


Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val 
    50                  55                  60                  


Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro 
65                  70                  75                  80  


Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Gly Gly Val Pro Gly 
                85                  90                  95      


Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala 
            100                 105                 110         


Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Val Gly 
        115                 120                 125             


Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Gly Gly Val 
    130                 135                 140                 


Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro 
145                 150                 155                 160 


Gly Ala Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly 
                165                 170                 175     


Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Gly 
            180                 185                 190         


Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly 
        195                 200                 205             


Val Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val 
    210                 215                 220                 


Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro 
225                 230                 235                 240 


Gly Gly Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly 
                245                 250                 255     


Gly Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro Gly Val 
            260                 265                 270         


Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly 
        275                 280                 285             


Val Pro Gly Gly Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val 
    290                 295                 300                 


Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro 
305                 310                 315                 320 


Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly 
                325                 330                 335     


Ala Gly Val Pro Gly Gly Gly Val Pro Gly Val Gly Val Pro Gly Val 
            340                 345                 350         


Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly 
        355                 360                 365             


Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val 
    370                 375                 380                 


Pro Gly Ala Gly Val Pro Gly Gly Gly Val Pro Gly Val Gly Val Pro 
385                 390                 395                 400 


Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly 
                405                 410                 415     


Val Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly 
            420                 425                 430         


Gly Val Pro Gly Ala Gly Val Pro Gly Gly Gly Val Pro Gly Val Gly 
        435                 440                 445             


Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val 
    450                 455                 460                 


Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro 
465                 470                 475                 480 


Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Gly Gly Val Pro Gly 
                485                 490                 495     


Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala 
            500                 505                 510         


Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Val Gly 
        515                 520                 525             


Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Gly Gly Val 
    530                 535                 540                 


Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro 
545                 550                 555                 560 


Gly Ala Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly 
                565                 570                 575     


Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Gly 
            580                 585                 590         


Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly 
        595                 600                 605             


Val Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val 
    610                 615                 620                 


Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro 
625                 630                 635                 640 


Gly Gly Gly Val Pro Gly Trp Pro 
                645             


<210>  91
<211>  168
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRAIL

<400>  91

Val Arg Glu Arg Gly Pro Gln Arg Val Ala Ala His Ile Thr Gly Thr 
1               5                   10                  15      


Arg Gly Arg Ser Asn Thr Leu Ser Ser Pro Asn Ser Lys Asn Glu Lys 
            20                  25                  30          


Ala Leu Gly Arg Lys Ile Asn Ser Trp Glu Ser Ser Arg Ser Gly His 
        35                  40                  45              


Ser Phe Leu Ser Asn Leu His Leu Arg Asn Gly Glu Leu Val Ile His 
    50                  55                  60                  


Glu Lys Gly Phe Tyr Tyr Ile Tyr Ser Gln Thr Tyr Phe Arg Phe Gln 
65                  70                  75                  80  


Glu Glu Ile Lys Glu Asn Thr Lys Asn Asp Lys Gln Met Val Gln Tyr 
                85                  90                  95      


Ile Tyr Lys Tyr Thr Ser Tyr Pro Asp Pro Ile Leu Leu Met Lys Ser 
            100                 105                 110         


Ala Arg Asn Ser Cys Trp Ser Lys Asp Ala Glu Tyr Gly Leu Tyr Ser 
        115                 120                 125             


Ile Tyr Gln Gly Gly Ile Phe Glu Leu Lys Glu Asn Asp Arg Ile Phe 
    130                 135                 140                 


Val Ser Val Thr Asn Glu His Leu Ile Asp Met Asp His Glu Ala Ser 
145                 150                 155                 160 


Phe Phe Gly Ala Phe Leu Val Gly 
                165             


<210>  92
<211>  777
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pPE0141 ELP1-120 TRAIL

<400>  92

Met Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly 
1               5                   10                  15      


Val Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val 
            20                  25                  30          


Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro 
        35                  40                  45              


Gly Gly Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly 
    50                  55                  60                  


Gly Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro Gly Val 
65                  70                  75                  80  


Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly 
                85                  90                  95      


Val Pro Gly Gly Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val 
            100                 105                 110         


Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro 
        115                 120                 125             


Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly 
    130                 135                 140                 


Ala Gly Val Pro Gly Gly Gly Val Pro Gly Val Gly Val Pro Gly Val 
145                 150                 155                 160 


Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly 
                165                 170                 175     


Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val 
            180                 185                 190         


Pro Gly Ala Gly Val Pro Gly Gly Gly Val Pro Gly Val Gly Val Pro 
        195                 200                 205             


Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly 
    210                 215                 220                 


Val Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly 
225                 230                 235                 240 


Gly Val Pro Gly Ala Gly Val Pro Gly Gly Gly Val Pro Gly Val Gly 
                245                 250                 255     


Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val 
            260                 265                 270         


Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro 
        275                 280                 285             


Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Gly Gly Val Pro Gly 
    290                 295                 300                 


Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala 
305                 310                 315                 320 


Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Val Gly 
                325                 330                 335     


Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Gly Gly Val 
            340                 345                 350         


Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro 
        355                 360                 365             


Gly Ala Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly 
    370                 375                 380                 


Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Gly 
385                 390                 395                 400 


Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly 
                405                 410                 415     


Val Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val 
            420                 425                 430         


Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro 
        435                 440                 445             


Gly Gly Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly 
    450                 455                 460                 


Gly Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro Gly Val 
465                 470                 475                 480 


Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly 
                485                 490                 495     


Val Pro Gly Gly Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val 
            500                 505                 510         


Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro 
        515                 520                 525             


Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly 
    530                 535                 540                 


Ala Gly Val Pro Gly Gly Gly Val Pro Gly Val Gly Val Pro Gly Val 
545                 550                 555                 560 


Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly 
                565                 570                 575     


Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val 
            580                 585                 590         


Pro Gly Ala Gly Val Pro Gly Gly Gly Val Pro Gly Val Pro Gly Gly 
        595                 600                 605             


Gly Val Arg Glu Arg Gly Pro Gln Arg Val Ala Ala His Ile Thr Gly 
    610                 615                 620                 


Thr Arg Gly Arg Ser Asn Thr Leu Ser Ser Pro Asn Ser Lys Asn Glu 
625                 630                 635                 640 


Lys Ala Leu Gly Arg Lys Ile Asn Ser Trp Glu Ser Ser Arg Ser Gly 
                645                 650                 655     


His Ser Phe Leu Ser Asn Leu His Leu Arg Asn Gly Glu Leu Val Ile 
            660                 665                 670         


His Glu Lys Gly Phe Tyr Tyr Ile Tyr Ser Gln Thr Tyr Phe Arg Phe 
        675                 680                 685             


Gln Glu Glu Ile Lys Glu Asn Thr Lys Asn Asp Lys Gln Met Val Gln 
    690                 695                 700                 


Tyr Ile Tyr Lys Tyr Thr Ser Tyr Pro Asp Pro Ile Leu Leu Met Lys 
705                 710                 715                 720 


Ser Ala Arg Asn Ser Cys Trp Ser Lys Asp Ala Glu Tyr Gly Leu Tyr 
                725                 730                 735     


Ser Ile Tyr Gln Gly Gly Ile Phe Glu Leu Lys Glu Asn Asp Arg Ile 
            740                 745                 750         


Phe Val Ser Val Thr Asn Glu His Leu Ile Asp Met Asp His Glu Ala 
        755                 760                 765             


Ser Phe Phe Gly Ala Phe Leu Val Gly 
    770                 775    

<210>  93
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GGGGS linker

<400>  93

Gly Gly Gly Gly Ser 
1               5   


<210>  94
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PAPAP linker

<400>  94

Pro Ala Pro Ala Pro 
1               5

<210>  95
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EAAAK linker

<400>  95

Glu Ala Ala Ala Lys 
1               5  


<210>  96
<211>  1950
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CNP37 GGS2x ELP1-120 fusion

<400>  96
caggaacatc cgaacgcgcg taaatataaa ggtgcgaaca aaaaaggcct gagcaaaggc       60

tgctttggcc tgaaactgga tcgcattggc agcatgagcg gcctgggctg cggtggctct      120

ggcggttctg taccgggcgt gggtgttccg ggcgtgggtg ttccgggtgg cggtgtgccg      180

ggcgcaggtg ttcctggtgt aggtgtgccg ggtgttggtg tgccgggtgt tggtgtacca      240

ggtggcggtg ttccgggtgc aggcgttccg ggtggcggtg tgccgggcgt gggtgttccg      300

ggcgtgggtg ttccgggtgg cggtgtgccg ggcgcaggtg ttcctggtgt aggtgtgccg      360

ggtgttggtg tgccgggtgt tggtgtacca ggtggcggtg ttccgggtgc aggcgttccg      420

ggtggcggtg tgccgggcgt gggtgttccg ggcgtgggtg ttccgggtgg cggtgtgccg      480

ggcgcaggtg ttcctggtgt aggtgtgccg ggtgttggtg tgccgggtgt tggtgtacca      540

ggtggcggtg ttccgggtgc aggcgttccg ggtggcggtg tgccgggcgt gggtgttccg      600

ggcgtgggtg ttccgggtgg cggtgtgccg ggcgcaggtg ttcctggtgt aggtgtgccg      660

ggtgttggtg tgccgggtgt tggtgtacca ggtggcggtg ttccgggtgc aggcgttccg      720

ggtggcggtg tgccgggcgt gggtgttccg ggcgtgggtg ttccgggtgg cggtgtgccg      780

ggcgcaggtg ttcctggtgt aggtgtgccg ggtgttggtg tgccgggtgt tggtgtacca      840

ggtggcggtg ttccgggtgc aggcgttccg ggtggcggtg tgccgggcgt gggtgttccg      900

ggcgtgggtg ttccgggtgg cggtgtgccg ggcgcaggtg ttcctggtgt aggtgtgccg      960

ggtgttggtg tgccgggtgt tggtgtacca ggtggcggtg ttccgggtgc aggcgttccg     1020

ggtggcggtg tgccgggcgt gggtgttccg ggcgtgggtg ttccgggtgg cggtgtgccg     1080

ggcgcaggtg ttcctggtgt aggtgtgccg ggtgttggtg tgccgggtgt tggtgtacca     1140

ggtggcggtg ttccgggtgc aggcgttccg ggtggcggtg tgccgggcgt gggtgttccg     1200

ggcgtgggtg ttccgggtgg cggtgtgccg ggcgcaggtg ttcctggtgt aggtgtgccg     1260

ggtgttggtg tgccgggtgt tggtgtacca ggtggcggtg ttccgggtgc aggcgttccg     1320

ggtggcggtg tgccgggcgt gggtgttccg ggcgtgggtg ttccgggtgg cggtgtgccg     1380

ggcgcaggtg ttcctggtgt aggtgtgccg ggtgttggtg tgccgggtgt tggtgtacca     1440

ggtggcggtg ttccgggtgc aggcgttccg ggtggcggtg tgccgggcgt gggtgttccg     1500

ggcgtgggtg ttccgggtgg cggtgtgccg ggcgcaggtg ttcctggtgt aggtgtgccg     1560

ggtgttggtg tgccgggtgt tggtgtacca ggtggcggtg ttccgggtgc aggcgttccg     1620

ggtggcggtg tgccgggcgt gggtgttccg ggcgtgggtg ttccgggtgg cggtgtgccg     1680

ggcgcaggtg ttcctggtgt aggtgtgccg ggtgttggtg tgccgggtgt tggtgtacca     1740

ggtggcggtg ttccgggtgc aggcgttccg ggtggcggtg tgccgggcgt gggtgttccg     1800

ggcgtgggtg ttccgggtgg cggtgtgccg ggcgcaggtg ttcctggtgt aggtgtgccg     1860

ggtgttggtg tgccgggtgt tggtgtacca ggtggcggtg ttccgggtgc aggcgttccg     1920

ggtggcggtg tgccgggctg gccgtgataa                                      1950


<210>  97
<211>  1890
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ELP1-120 CNP22 fusion

<400>  97
atggtaccgg gcgtgggtgt tccgggcgtg ggtgttccgg gtggcggtgt gccgggcgca       60

ggtgttcctg gtgtaggtgt gccgggtgtt ggtgtgccgg gtgttggtgt accaggtggc      120

ggtgttccgg gtgcaggcgt tccgggtggc ggtgtgccgg gcgtgggtgt tccgggcgtg      180

ggtgttccgg gtggcggtgt gccgggcgca ggtgttcctg gtgtaggtgt gccgggtgtt      240

ggtgtgccgg gtgttggtgt accaggtggc ggtgttccgg gtgcaggcgt tccgggtggc      300

ggtgtgccgg gcgtgggtgt tccgggcgtg ggtgttccgg gtggcggtgt gccgggcgca      360

ggtgttcctg gtgtaggtgt gccgggtgtt ggtgtgccgg gtgttggtgt accaggtggc      420

ggtgttccgg gtgcaggcgt tccgggtggc ggtgtgccgg gcgtgggtgt tccgggcgtg      480

ggtgttccgg gtggcggtgt gccgggcgca ggtgttcctg gtgtaggtgt gccgggtgtt      540

ggtgtgccgg gtgttggtgt accaggtggc ggtgttccgg gtgcaggcgt tccgggtggc      600

ggtgtgccgg gcgtgggtgt tccgggcgtg ggtgttccgg gtggcggtgt gccgggcgca      660

ggtgttcctg gtgtaggtgt gccgggtgtt ggtgtgccgg gtgttggtgt accaggtggc      720

ggtgttccgg gtgcaggcgt tccgggtggc ggtgtgccgg gcgtgggtgt tccgggcgtg      780

ggtgttccgg gtggcggtgt gccgggcgca ggtgttcctg gtgtaggtgt gccgggtgtt      840

ggtgtgccgg gtgttggtgt accaggtggc ggtgttccgg gtgcaggcgt tccgggtggc      900

ggtgtgccgg gcgtgggtgt tccgggcgtg ggtgttccgg gtggcggtgt gccgggcgca      960

ggtgttcctg gtgtaggtgt gccgggtgtt ggtgtgccgg gtgttggtgt accaggtggc     1020

ggtgttccgg gtgcaggcgt tccgggtggc ggtgtgccgg gcgtgggtgt tccgggcgtg     1080

ggtgttccgg gtggcggtgt gccgggcgca ggtgttcctg gtgtaggtgt gccgggtgtt     1140

ggtgtgccgg gtgttggtgt accaggtggc ggtgttccgg gtgcaggcgt tccgggtggc     1200

ggtgtgccgg gcgtgggtgt tccgggcgtg ggtgttccgg gtggcggtgt gccgggcgca     1260

ggtgttcctg gtgtaggtgt gccgggtgtt ggtgtgccgg gtgttggtgt accaggtggc     1320

ggtgttccgg gtgcaggcgt tccgggtggc ggtgtgccgg gcgtgggtgt tccgggcgtg     1380

ggtgttccgg gtggcggtgt gccgggcgca ggtgttcctg gtgtaggtgt gccgggtgtt     1440

ggtgtgccgg gtgttggtgt accaggtggc ggtgttccgg gtgcaggcgt tccgggtggc     1500

ggtgtgccgg gcgtgggtgt tccgggcgtg ggtgttccgg gtggcggtgt gccgggcgca     1560

ggtgttcctg gtgtaggtgt gccgggtgtt ggtgtgccgg gtgttggtgt accaggtggc     1620

ggtgttccgg gtgcaggcgt tccgggtggc ggtgtgccgg gcgtgggtgt tccgggcgtg     1680

ggtgttccgg gtggcggtgt gccgggcgca ggtgttcctg gtgtaggtgt gccgggtgtt     1740

ggtgtgccgg gtgttggtgt accaggtggc ggtgttccgg gtgcaggcgt tccgggtggc     1800

ggtgtgccgg gctggccggg cctgagcaaa ggctgctttg gcctgaaact ggatcgcatt     1860

ggcagcatga gcggcctggg ctgctgataa                                      1890


<210>  98
<211>  628
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CNP22 ELP1-120 fusion

<400>  98

Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser 
1               5                   10                  15      


Met Ser Gly Leu Gly Cys Gly Val Pro Gly Val Gly Val Pro Gly Val 
            20                  25                  30          


Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly 
        35                  40                  45              


Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val 
    50                  55                  60                  


Pro Gly Ala Gly Val Pro Gly Gly Gly Val Pro Gly Val Gly Val Pro 
65                  70                  75                  80  


Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly 
                85                  90                  95      


Val Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly 
            100                 105                 110         


Gly Val Pro Gly Ala Gly Val Pro Gly Gly Gly Val Pro Gly Val Gly 
        115                 120                 125             


Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val 
    130                 135                 140                 


Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro 
145                 150                 155                 160 


Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Gly Gly Val Pro Gly 
                165                 170                 175     


Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala 
            180                 185                 190         


Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Val Gly 
        195                 200                 205             


Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Gly Gly Val 
    210                 215                 220                 


Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro 
225                 230                 235                 240 


Gly Ala Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly 
                245                 250                 255     


Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Gly 
            260                 265                 270         


Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly 
        275                 280                 285             


Val Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val 
    290                 295                 300                 


Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro 
305                 310                 315                 320 


Gly Gly Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly 
                325                 330                 335     


Gly Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro Gly Val 
            340                 345                 350         


Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly 
        355                 360                 365             


Val Pro Gly Gly Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val 
    370                 375                 380                 


Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro 
385                 390                 395                 400 


Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly 
                405                 410                 415     


Ala Gly Val Pro Gly Gly Gly Val Pro Gly Val Gly Val Pro Gly Val 
            420                 425                 430         


Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly 
        435                 440                 445             


Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val 
    450                 455                 460                 


Pro Gly Ala Gly Val Pro Gly Gly Gly Val Pro Gly Val Gly Val Pro 
465                 470                 475                 480 


Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly 
                485                 490                 495     


Val Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly 
            500                 505                 510         


Gly Val Pro Gly Ala Gly Val Pro Gly Gly Gly Val Pro Gly Val Gly 
        515                 520                 525             


Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val 
    530                 535                 540                 


Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro 
545                 550                 555                 560 


Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Gly Gly Val Pro Gly 
                565                 570                 575     


Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala 
            580                 585                 590         


Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Val Gly 
        595                 600                 605             


Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Gly Gly Val 
    610                 615                 620                 


Pro Gly Trp Pro 
625             

<210>  99
<211>  1890
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CNP ELP1-120 fusion

<400>  99
ggcctgagca aaggctgctt tggcctgaaa ctggatcgca ttggcagcat gagcggcctg       60

ggctgcggtg taccgggcgt gggtgttccg ggcgtgggtg ttccgggtgg cggtgtgccg      120

ggcgcaggtg ttcctggtgt aggtgtgccg ggtgttggtg tgccgggtgt tggtgtacca      180

ggtggcggtg ttccgggtgc aggcgttccg ggtggcggtg tgccgggcgt gggtgttccg      240

ggcgtgggtg ttccgggtgg cggtgtgccg ggcgcaggtg ttcctggtgt aggtgtgccg      300

ggtgttggtg tgccgggtgt tggtgtacca ggtggcggtg ttccgggtgc aggcgttccg      360

ggtggcggtg tgccgggcgt gggtgttccg ggcgtgggtg ttccgggtgg cggtgtgccg      420

ggcgcaggtg ttcctggtgt aggtgtgccg ggtgttggtg tgccgggtgt tggtgtacca      480

ggtggcggtg ttccgggtgc aggcgttccg ggtggcggtg tgccgggcgt gggtgttccg      540

ggcgtgggtg ttccgggtgg cggtgtgccg ggcgcaggtg ttcctggtgt aggtgtgccg      600

ggtgttggtg tgccgggtgt tggtgtacca ggtggcggtg ttccgggtgc aggcgttccg      660

ggtggcggtg tgccgggcgt gggtgttccg ggcgtgggtg ttccgggtgg cggtgtgccg      720

ggcgcaggtg ttcctggtgt aggtgtgccg ggtgttggtg tgccgggtgt tggtgtacca      780

ggtggcggtg ttccgggtgc aggcgttccg ggtggcggtg tgccgggcgt gggtgttccg      840

ggcgtgggtg ttccgggtgg cggtgtgccg ggcgcaggtg ttcctggtgt aggtgtgccg      900

ggtgttggtg tgccgggtgt tggtgtacca ggtggcggtg ttccgggtgc aggcgttccg      960

ggtggcggtg tgccgggcgt gggtgttccg ggcgtgggtg ttccgggtgg cggtgtgccg     1020

ggcgcaggtg ttcctggtgt aggtgtgccg ggtgttggtg tgccgggtgt tggtgtacca     1080

ggtggcggtg ttccgggtgc aggcgttccg ggtggcggtg tgccgggcgt gggtgttccg     1140

ggcgtgggtg ttccgggtgg cggtgtgccg ggcgcaggtg ttcctggtgt aggtgtgccg     1200

ggtgttggtg tgccgggtgt tggtgtacca ggtggcggtg ttccgggtgc aggcgttccg     1260

ggtggcggtg tgccgggcgt gggtgttccg ggcgtgggtg ttccgggtgg cggtgtgccg     1320

ggcgcaggtg ttcctggtgt aggtgtgccg ggtgttggtg tgccgggtgt tggtgtacca     1380

ggtggcggtg ttccgggtgc aggcgttccg ggtggcggtg tgccgggcgt gggtgttccg     1440

ggcgtgggtg ttccgggtgg cggtgtgccg ggcgcaggtg ttcctggtgt aggtgtgccg     1500

ggtgttggtg tgccgggtgt tggtgtacca ggtggcggtg ttccgggtgc aggcgttccg     1560

ggtggcggtg tgccgggcgt gggtgttccg ggcgtgggtg ttccgggtgg cggtgtgccg     1620

ggcgcaggtg ttcctggtgt aggtgtgccg ggtgttggtg tgccgggtgt tggtgtacca     1680

ggtggcggtg ttccgggtgc aggcgttccg ggtggcggtg tgccgggcgt gggtgttccg     1740

ggcgtgggtg ttccgggtgg cggtgtgccg ggcgcaggtg ttcctggtgt aggtgtgccg     1800

ggtgttggtg tgccgggtgt tggtgtacca ggtggcggtg ttccgggtgc aggcgttccg     1860

ggtggcggtg tgccgggctg gccgtgataa                                      1890


<210>  100
<211>  1905
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CNP22 GGS2X ELP1-120 fusion 

<400>  100
ggcctgagca aaggctgctt tggcctgaaa ctggatcgca ttggcagcat gagcggcctg       60

ggctgcggtg gctctggcgg ttctgtaccg ggcgtgggtg ttccgggcgt gggtgttccg      120

ggtggcggtg tgccgggcgc aggtgttcct ggtgtaggtg tgccgggtgt tggtgtgccg      180

ggtgttggtg taccaggtgg cggtgttccg ggtgcaggcg ttccgggtgg cggtgtgccg      240

ggcgtgggtg ttccgggcgt gggtgttccg ggtggcggtg tgccgggcgc aggtgttcct      300

ggtgtaggtg tgccgggtgt tggtgtgccg ggtgttggtg taccaggtgg cggtgttccg      360

ggtgcaggcg ttccgggtgg cggtgtgccg ggcgtgggtg ttccgggcgt gggtgttccg      420

ggtggcggtg tgccgggcgc aggtgttcct ggtgtaggtg tgccgggtgt tggtgtgccg      480

ggtgttggtg taccaggtgg cggtgttccg ggtgcaggcg ttccgggtgg cggtgtgccg      540

ggcgtgggtg ttccgggcgt gggtgttccg ggtggcggtg tgccgggcgc aggtgttcct      600

ggtgtaggtg tgccgggtgt tggtgtgccg ggtgttggtg taccaggtgg cggtgttccg      660

ggtgcaggcg ttccgggtgg cggtgtgccg ggcgtgggtg ttccgggcgt gggtgttccg      720

ggtggcggtg tgccgggcgc aggtgttcct ggtgtaggtg tgccgggtgt tggtgtgccg      780

ggtgttggtg taccaggtgg cggtgttccg ggtgcaggcg ttccgggtgg cggtgtgccg      840

ggcgtgggtg ttccgggcgt gggtgttccg ggtggcggtg tgccgggcgc aggtgttcct      900

ggtgtaggtg tgccgggtgt tggtgtgccg ggtgttggtg taccaggtgg cggtgttccg      960

ggtgcaggcg ttccgggtgg cggtgtgccg ggcgtgggtg ttccgggcgt gggtgttccg     1020

ggtggcggtg tgccgggcgc aggtgttcct ggtgtaggtg tgccgggtgt tggtgtgccg     1080

ggtgttggtg taccaggtgg cggtgttccg ggtgcaggcg ttccgggtgg cggtgtgccg     1140

ggcgtgggtg ttccgggcgt gggtgttccg ggtggcggtg tgccgggcgc aggtgttcct     1200

ggtgtaggtg tgccgggtgt tggtgtgccg ggtgttggtg taccaggtgg cggtgttccg     1260

ggtgcaggcg ttccgggtgg cggtgtgccg ggcgtgggtg ttccgggcgt gggtgttccg     1320

ggtggcggtg tgccgggcgc aggtgttcct ggtgtaggtg tgccgggtgt tggtgtgccg     1380

ggtgttggtg taccaggtgg cggtgttccg ggtgcaggcg ttccgggtgg cggtgtgccg     1440

ggcgtgggtg ttccgggcgt gggtgttccg ggtggcggtg tgccgggcgc aggtgttcct     1500

ggtgtaggtg tgccgggtgt tggtgtgccg ggtgttggtg taccaggtgg cggtgttccg     1560

ggtgcaggcg ttccgggtgg cggtgtgccg ggcgtgggtg ttccgggcgt gggtgttccg     1620

ggtggcggtg tgccgggcgc aggtgttcct ggtgtaggtg tgccgggtgt tggtgtgccg     1680

ggtgttggtg taccaggtgg cggtgttccg ggtgcaggcg ttccgggtgg cggtgtgccg     1740

ggcgtgggtg ttccgggcgt gggtgttccg ggtggcggtg tgccgggcgc aggtgttcct     1800

ggtgtaggtg tgccgggtgt tggtgtgccg ggtgttggtg taccaggtgg cggtgttccg     1860

ggtgcaggcg ttccgggtgg cggtgtgccg ggctggccgt gataa                     1905

<210>  101
<211>  1920
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  GLP-2 ELP1-120 fusion

<400>  101
cacggcgatg gcagcttttc tgatgaaatg aataccattc tggacaacct ggcagcacgc       60

gactttatta actggctgat tcagacgaaa attactgatg taccgggcgt gggtgttccg      120

ggcgtgggtg ttccgggtgg cggtgtgccg ggcgcaggtg ttcctggtgt aggtgtgccg      180

ggtgttggtg tgccgggtgt tggtgtacca ggtggcggtg ttccgggtgc aggcgttccg      240

ggtggcggtg tgccgggcgt gggtgttccg ggcgtgggtg ttccgggtgg cggtgtgccg      300

ggcgcaggtg ttcctggtgt aggtgtgccg ggtgttggtg tgccgggtgt tggtgtacca      360

ggtggcggtg ttccgggtgc aggcgttccg ggtggcggtg tgccgggcgt gggtgttccg      420

ggcgtgggtg ttccgggtgg cggtgtgccg ggcgcaggtg ttcctggtgt aggtgtgccg      480

ggtgttggtg tgccgggtgt tggtgtacca ggtggcggtg ttccgggtgc aggcgttccg      540

ggtggcggtg tgccgggcgt gggtgttccg ggcgtgggtg ttccgggtgg cggtgtgccg      600

ggcgcaggtg ttcctggtgt aggtgtgccg ggtgttggtg tgccgggtgt tggtgtacca      660

ggtggcggtg ttccgggtgc aggcgttccg ggtggcggtg tgccgggcgt gggtgttccg      720

ggcgtgggtg ttccgggtgg cggtgtgccg ggcgcaggtg ttcctggtgt aggtgtgccg      780

ggtgttggtg tgccgggtgt tggtgtacca ggtggcggtg ttccgggtgc aggcgttccg      840

ggtggcggtg tgccgggcgt gggtgttccg ggcgtgggtg ttccgggtgg cggtgtgccg      900

ggcgcaggtg ttcctggtgt aggtgtgccg ggtgttggtg tgccgggtgt tggtgtacca      960

ggtggcggtg ttccgggtgc aggcgttccg ggtggcggtg tgccgggcgt gggtgttccg     1020

ggcgtgggtg ttccgggtgg cggtgtgccg ggcgcaggtg ttcctggtgt aggtgtgccg     1080

ggtgttggtg tgccgggtgt tggtgtacca ggtggcggtg ttccgggtgc aggcgttccg     1140

ggtggcggtg tgccgggcgt gggtgttccg ggcgtgggtg ttccgggtgg cggtgtgccg     1200

ggcgcaggtg ttcctggtgt aggtgtgccg ggtgttggtg tgccgggtgt tggtgtacca     1260

ggtggcggtg ttccgggtgc aggcgttccg ggtggcggtg tgccgggcgt gggtgttccg     1320

ggcgtgggtg ttccgggtgg cggtgtgccg ggcgcaggtg ttcctggtgt aggtgtgccg     1380

ggtgttggtg tgccgggtgt tggtgtacca ggtggcggtg ttccgggtgc aggcgttccg     1440

ggtggcggtg tgccgggcgt gggtgttccg ggcgtgggtg ttccgggtgg cggtgtgccg     1500

ggcgcaggtg ttcctggtgt aggtgtgccg ggtgttggtg tgccgggtgt tggtgtacca     1560

ggtggcggtg ttccgggtgc aggcgttccg ggtggcggtg tgccgggcgt gggtgttccg     1620

ggcgtgggtg ttccgggtgg cggtgtgccg ggcgcaggtg ttcctggtgt aggtgtgccg     1680

ggtgttggtg tgccgggtgt tggtgtacca ggtggcggtg ttccgggtgc aggcgttccg     1740

ggtggcggtg tgccgggcgt gggtgttccg ggcgtgggtg ttccgggtgg cggtgtgccg     1800

ggcgcaggtg ttcctggtgt aggtgtgccg ggtgttggtg tgccgggtgt tggtgtacca     1860

ggtggcggtg ttccgggtgc aggcgttccg ggtggcggtg tgccgggctg gccgtgataa     1920


<210>  102
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GGS 2X

<400>  102

Gly Gly Ser Gly Gly Ser 
1               5       


<210>  103
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GGS 3X

<400>  103

Gly Gly Ser Gly Gly Ser Gly Gly Ser 
1               5  

<210>  104
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GGGGS 2X

<400>  104

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10  


<210>  105
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GGGGS 3X

<400>  105

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15 

<210>  106
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PAPAP 2X

<400>  106

Pro Ala Pro Ala Pro Pro Ala Pro Ala Pro 
1                5                  10


<210>  107
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PAPAP 3X

<400>  107

Pro Ala Pro Ala Pro Pro Ala Pro Ala Pro Pro Ala Pro Ala Pro 
1               5                   10                  15  

<210>  108
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EAAAK 2X

<400>  108

Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys 
1               5                   10  


<210>  109
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EAAAK 3X

<400>  109

Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys 
1               5                   10                  15 

<210>  110
<211>  209
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FGF21

<400>  110

Met Asp Ser Asp Glu Thr Gly Phe Glu His Ser Gly Leu Trp Val Ser 
1               5                   10                  15      


Val Leu Ala Gly Leu Leu Leu Gly Ala Cys Gln Ala His Pro Ile Pro 
            20                  25                  30          


Asp Ser Ser Pro Leu Leu Gln Phe Gly Gly Gln Val Arg Gln Arg Tyr 
        35                  40                  45              


Leu Tyr Thr Asp Asp Ala Gln Gln Thr Glu Ala His Leu Glu Ile Arg 
    50                  55                  60                  


Glu Asp Gly Thr Val Gly Gly Ala Ala Asp Gln Ser Pro Glu Ser Leu 
65                  70                  75                  80  


Leu Gln Leu Lys Ala Leu Lys Pro Gly Val Ile Gln Ile Leu Gly Val 
                85                  90                  95      


Lys Thr Ser Arg Phe Leu Cys Gln Arg Pro Asp Gly Ala Leu Tyr Gly 
            100                 105                 110         


Ser Leu His Phe Asp Pro Glu Ala Cys Ser Phe Arg Glu Leu Leu Leu 
        115                 120                 125             


Glu Asp Gly Tyr Asn Val Tyr Gln Ser Glu Ala His Gly Leu Pro Leu 
    130                 135                 140                 


His Leu Pro Gly Asn Lys Ser Pro His Arg Asp Pro Ala Pro Arg Gly 
145                 150                 155                 160 


Pro Ala Arg Phe Leu Pro Leu Pro Gly Leu Pro Pro Ala Leu Pro Glu 
                165                 170                 175     


Pro Pro Gly Ile Leu Ala Pro Gln Pro Pro Asp Val Gly Ser Ser Asp 
            180                 185                 190         


Pro Leu Ser Met Val Gly Pro Ser Gln Gly Arg Ser Pro Ser Tyr Ala 
        195                 200                 205             


Ser 
    


<210>  111
<211>  663
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CNP53 CatK ELP1-120 fusion PE9446

<400>  111

Asp Leu Arg Val Asp Thr Lys Ser Arg Ala Ala Trp Ala Arg Leu Leu 
1               5                   10                  15      


Gln Glu His Pro Asn Ala Arg Lys Tyr Lys Gly Ala Asn Lys Lys Gly 
            20                  25                  30          


Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser Met 
        35                  40                  45              


Ser Gly Leu Gly Cys Arg Lys Pro Arg Gly Val Pro Gly Val Gly Val 
    50                  55                  60                  


Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro 
65                  70                  75                  80  


Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly 
                85                  90                  95      


Gly Gly Val Pro Gly Ala Gly Val Pro Gly Gly Gly Val Pro Gly Val 
            100                 105                 110         


Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly 
        115                 120                 125             


Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val 
    130                 135                 140                 


Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Gly Gly Val Pro 
145                 150                 155                 160 


Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly 
                165                 170                 175     


Ala Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Val 
            180                 185                 190         


Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Gly Gly 
        195                 200                 205             


Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val 
    210                 215                 220                 


Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro 
225                 230                 235                 240 


Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly 
                245                 250                 255     


Gly Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly 
            260                 265                 270         


Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro Gly Val Gly 
        275                 280                 285             


Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val 
    290                 295                 300                 


Pro Gly Gly Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro 
305                 310                 315                 320 


Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro Gly 
                325                 330                 335     


Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala 
            340                 345                 350         


Gly Val Pro Gly Gly Gly Val Pro Gly Val Gly Val Pro Gly Val Gly 
        355                 360                 365             


Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly Val 
    370                 375                 380                 


Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro 
385                 390                 395                 400 


Gly Ala Gly Val Pro Gly Gly Gly Val Pro Gly Val Gly Val Pro Gly 
                405                 410                 415     


Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Val 
            420                 425                 430         


Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly 
        435                 440                 445             


Val Pro Gly Ala Gly Val Pro Gly Gly Gly Val Pro Gly Val Gly Val 
    450                 455                 460                 


Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro 
465                 470                 475                 480 


Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly 
                485                 490                 495     


Gly Gly Val Pro Gly Ala Gly Val Pro Gly Gly Gly Val Pro Gly Val 
            500                 505                 510         


Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly 
        515                 520                 525             


Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val 
    530                 535                 540                 


Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Gly Gly Val Pro 
545                 550                 555                 560 


Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly 
                565                 570                 575     


Ala Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Val 
            580                 585                 590         


Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Gly Gly 
        595                 600                 605             


Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val 
    610                 615                 620                 


Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro 
625                 630                 635                 640 


Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly 
                645                 650                 655     


Gly Gly Val Pro Gly Trp Pro 
            660             


<210>  112
<211>  1989
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CNP53 CatK ELP1-120 fusion PE9446

<400>  112
gatctgcgcg tggataccaa aagccgcgcg gcgtgggcgc gcctgctgca ggaacatccg       60

aacgcgcgca aatataaagg cgcgaacaaa aaaggcctga gcaaaggctg ctttggcctg      120

aaactggatc gcattggcag catgagcggc ctgggctgcc gcaaaccgcg cggtgtaccg      180

ggcgtgggtg ttccgggcgt gggtgttccg ggtggcggtg tgccgggcgc aggtgttcct      240

ggtgtaggtg tgccgggtgt tggtgtgccg ggtgttggtg taccaggtgg cggtgttccg      300

ggtgcaggcg ttccgggtgg cggtgtgccg ggcgtgggtg ttccgggcgt gggtgttccg      360

ggtggcggtg tgccgggcgc aggtgttcct ggtgtaggtg tgccgggtgt tggtgtgccg      420

ggtgttggtg taccaggtgg cggtgttccg ggtgcaggcg ttccgggtgg cggtgtgccg      480

ggcgtgggtg ttccgggcgt gggtgttccg ggtggcggtg tgccgggcgc aggtgttcct      540

ggtgtaggtg tgccgggtgt tggtgtgccg ggtgttggtg taccaggtgg cggtgttccg      600

ggtgcaggcg ttccgggtgg cggtgtgccg ggcgtgggtg ttccgggcgt gggtgttccg      660

ggtggcggtg tgccgggcgc aggtgttcct ggtgtaggtg tgccgggtgt tggtgtgccg      720

ggtgttggtg taccaggtgg cggtgttccg ggtgcaggcg ttccgggtgg cggtgtgccg      780

ggcgtgggtg ttccgggcgt gggtgttccg ggtggcggtg tgccgggcgc aggtgttcct      840

ggtgtaggtg tgccgggtgt tggtgtgccg ggtgttggtg taccaggtgg cggtgttccg      900

ggtgcaggcg ttccgggtgg cggtgtgccg ggcgtgggtg ttccgggcgt gggtgttccg      960

ggtggcggtg tgccgggcgc aggtgttcct ggtgtaggtg tgccgggtgt tggtgtgccg     1020

ggtgttggtg taccaggtgg cggtgttccg ggtgcaggcg ttccgggtgg cggtgtgccg     1080

ggcgtgggtg ttccgggcgt gggtgttccg ggtggcggtg tgccgggcgc aggtgttcct     1140

ggtgtaggtg tgccgggtgt tggtgtgccg ggtgttggtg taccaggtgg cggtgttccg     1200

ggtgcaggcg ttccgggtgg cggtgtgccg ggcgtgggtg ttccgggcgt gggtgttccg     1260

ggtggcggtg tgccgggcgc aggtgttcct ggtgtaggtg tgccgggtgt tggtgtgccg     1320

ggtgttggtg taccaggtgg cggtgttccg ggtgcaggcg ttccgggtgg cggtgtgccg     1380

ggcgtgggtg ttccgggcgt gggtgttccg ggtggcggtg tgccgggcgc aggtgttcct     1440

ggtgtaggtg tgccgggtgt tggtgtgccg ggtgttggtg taccaggtgg cggtgttccg     1500

ggtgcaggcg ttccgggtgg cggtgtgccg ggcgtgggtg ttccgggcgt gggtgttccg     1560

ggtggcggtg tgccgggcgc aggtgttcct ggtgtaggtg tgccgggtgt tggtgtgccg     1620

ggtgttggtg taccaggtgg cggtgttccg ggtgcaggcg ttccgggtgg cggtgtgccg     1680

ggcgtgggtg ttccgggcgt gggtgttccg ggtggcggtg tgccgggcgc aggtgttcct     1740

ggtgtaggtg tgccgggtgt tggtgtgccg ggtgttggtg taccaggtgg cggtgttccg     1800

ggtgcaggcg ttccgggtgg cggtgtgccg ggcgtgggtg ttccgggcgt gggtgttccg     1860

ggtggcggtg tgccgggcgc aggtgttcct ggtgtaggtg tgccgggtgt tggtgtgccg     1920

ggtgttggtg taccaggtgg cggtgttccg ggtgcaggcg ttccgggtgg cggtgtgccg     1980

ggctggccg                                                             1989


<210>  113
<211>  632
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CNP22 CatK ELP1-120 fusion PE9456

<400>  113

Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser 
1               5                   10                  15      


Met Ser Gly Leu Gly Cys Arg Lys Pro Arg Gly Val Pro Gly Val Gly 
            20                  25                  30          


Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val 
        35                  40                  45              


Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro 
    50                  55                  60                  


Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Gly Gly Val Pro Gly 
65                  70                  75                  80  


Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala 
                85                  90                  95      


Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Val Gly 
            100                 105                 110         


Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Gly Gly Val 
        115                 120                 125             


Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro 
    130                 135                 140                 


Gly Ala Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly 
145                 150                 155                 160 


Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Gly 
                165                 170                 175     


Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly 
            180                 185                 190         


Val Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val 
        195                 200                 205             


Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro 
    210                 215                 220                 


Gly Gly Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly 
225                 230                 235                 240 


Gly Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro Gly Val 
                245                 250                 255     


Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly 
            260                 265                 270         


Val Pro Gly Gly Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val 
        275                 280                 285             


Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro 
    290                 295                 300                 


Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly 
305                 310                 315                 320 


Ala Gly Val Pro Gly Gly Gly Val Pro Gly Val Gly Val Pro Gly Val 
                325                 330                 335     


Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly 
            340                 345                 350         


Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val 
        355                 360                 365             


Pro Gly Ala Gly Val Pro Gly Gly Gly Val Pro Gly Val Gly Val Pro 
    370                 375                 380                 


Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly 
385                 390                 395                 400 


Val Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly 
                405                 410                 415     


Gly Val Pro Gly Ala Gly Val Pro Gly Gly Gly Val Pro Gly Val Gly 
            420                 425                 430         


Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val 
        435                 440                 445             


Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro 
    450                 455                 460                 


Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Gly Gly Val Pro Gly 
465                 470                 475                 480 


Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala 
                485                 490                 495     


Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Val Gly 
            500                 505                 510         


Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Gly Gly Val 
        515                 520                 525             


Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro 
    530                 535                 540                 


Gly Ala Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly 
545                 550                 555                 560 


Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Gly 
                565                 570                 575     


Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly 
            580                 585                 590         


Val Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val 
        595                 600                 605             


Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro 
    610                 615                 620                 


Gly Gly Gly Val Pro Gly Trp Pro 
625                 630         


<210>  114
<211>  1896
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CNP22 CatK ELP1-120 fusion PE9456

<400>  114
ggcctgagca aaggctgctt tggcctgaaa ctggatcgca ttggcagcat gagcggcctg       60

ggctgccgca aaccgcgcgg tgtaccgggc gtgggtgttc cgggcgtggg tgttccgggt      120

ggcggtgtgc cgggcgcagg tgttcctggt gtaggtgtgc cgggtgttgg tgtgccgggt      180

gttggtgtac caggtggcgg tgttccgggt gcaggcgttc cgggtggcgg tgtgccgggc      240

gtgggtgttc cgggcgtggg tgttccgggt ggcggtgtgc cgggcgcagg tgttcctggt      300

gtaggtgtgc cgggtgttgg tgtgccgggt gttggtgtac caggtggcgg tgttccgggt      360

gcaggcgttc cgggtggcgg tgtgccgggc gtgggtgttc cgggcgtggg tgttccgggt      420

ggcggtgtgc cgggcgcagg tgttcctggt gtaggtgtgc cgggtgttgg tgtgccgggt      480

gttggtgtac caggtggcgg tgttccgggt gcaggcgttc cgggtggcgg tgtgccgggc      540

gtgggtgttc cgggcgtggg tgttccgggt ggcggtgtgc cgggcgcagg tgttcctggt      600

gtaggtgtgc cgggtgttgg tgtgccgggt gttggtgtac caggtggcgg tgttccgggt      660

gcaggcgttc cgggtggcgg tgtgccgggc gtgggtgttc cgggcgtggg tgttccgggt      720

ggcggtgtgc cgggcgcagg tgttcctggt gtaggtgtgc cgggtgttgg tgtgccgggt      780

gttggtgtac caggtggcgg tgttccgggt gcaggcgttc cgggtggcgg tgtgccgggc      840

gtgggtgttc cgggcgtggg tgttccgggt ggcggtgtgc cgggcgcagg tgttcctggt      900

gtaggtgtgc cgggtgttgg tgtgccgggt gttggtgtac caggtggcgg tgttccgggt      960

gcaggcgttc cgggtggcgg tgtgccgggc gtgggtgttc cgggcgtggg tgttccgggt     1020

ggcggtgtgc cgggcgcagg tgttcctggt gtaggtgtgc cgggtgttgg tgtgccgggt     1080

gttggtgtac caggtggcgg tgttccgggt gcaggcgttc cgggtggcgg tgtgccgggc     1140

gtgggtgttc cgggcgtggg tgttccgggt ggcggtgtgc cgggcgcagg tgttcctggt     1200

gtaggtgtgc cgggtgttgg tgtgccgggt gttggtgtac caggtggcgg tgttccgggt     1260

gcaggcgttc cgggtggcgg tgtgccgggc gtgggtgttc cgggcgtggg tgttccgggt     1320

ggcggtgtgc cgggcgcagg tgttcctggt gtaggtgtgc cgggtgttgg tgtgccgggt     1380

gttggtgtac caggtggcgg tgttccgggt gcaggcgttc cgggtggcgg tgtgccgggc     1440

gtgggtgttc cgggcgtggg tgttccgggt ggcggtgtgc cgggcgcagg tgttcctggt     1500

gtaggtgtgc cgggtgttgg tgtgccgggt gttggtgtac caggtggcgg tgttccgggt     1560

gcaggcgttc cgggtggcgg tgtgccgggc gtgggtgttc cgggcgtggg tgttccgggt     1620

ggcggtgtgc cgggcgcagg tgttcctggt gtaggtgtgc cgggtgttgg tgtgccgggt     1680

gttggtgtac caggtggcgg tgttccgggt gcaggcgttc cgggtggcgg tgtgccgggc     1740

gtgggtgttc cgggcgtggg tgttccgggt ggcggtgtgc cgggcgcagg tgttcctggt     1800

gtaggtgtgc cgggtgttgg tgtgccgggt gttggtgtac caggtggcgg tgttccgggt     1860

gcaggcgttc cgggtggcgg tgtgccgggc tggccg                               1896


<210>  115
<211>  648
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ELP1-120 CatK CNP37 fusion PE9486

<400>  115

Met Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly 
1               5                   10                  15      


Val Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val 
            20                  25                  30          


Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro 
        35                  40                  45              


Gly Gly Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly 
    50                  55                  60                  


Gly Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro Gly Val 
65                  70                  75                  80  


Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly 
                85                  90                  95      


Val Pro Gly Gly Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val 
            100                 105                 110         


Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro 
        115                 120                 125             


Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly 
    130                 135                 140                 


Ala Gly Val Pro Gly Gly Gly Val Pro Gly Val Gly Val Pro Gly Val 
145                 150                 155                 160 


Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly 
                165                 170                 175     


Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val 
            180                 185                 190         


Pro Gly Ala Gly Val Pro Gly Gly Gly Val Pro Gly Val Gly Val Pro 
        195                 200                 205             


Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly 
    210                 215                 220                 


Val Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly 
225                 230                 235                 240 


Gly Val Pro Gly Ala Gly Val Pro Gly Gly Gly Val Pro Gly Val Gly 
                245                 250                 255     


Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val 
            260                 265                 270         


Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro 
        275                 280                 285             


Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Gly Gly Val Pro Gly 
    290                 295                 300                 


Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala 
305                 310                 315                 320 


Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Val Gly 
                325                 330                 335     


Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Gly Gly Val 
            340                 345                 350         


Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro 
        355                 360                 365             


Gly Ala Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly 
    370                 375                 380                 


Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Gly 
385                 390                 395                 400 


Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly 
                405                 410                 415     


Val Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val 
            420                 425                 430         


Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro 
        435                 440                 445             


Gly Gly Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly 
    450                 455                 460                 


Gly Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro Gly Val 
465                 470                 475                 480 


Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly 
                485                 490                 495     


Val Pro Gly Gly Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val 
            500                 505                 510         


Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro 
        515                 520                 525             


Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly 
    530                 535                 540                 


Ala Gly Val Pro Gly Gly Gly Val Pro Gly Val Gly Val Pro Gly Val 
545                 550                 555                 560 


Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly 
                565                 570                 575     


Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val 
            580                 585                 590         


Pro Gly Ala Gly Val Pro Gly Gly Gly Val Pro Gly Trp Pro Arg Lys 
        595                 600                 605             


Pro Arg Gly Gln Glu His Pro Asn Ala Arg Lys Tyr Lys Gly Ala Asn 
    610                 615                 620                 


Lys Lys Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile 
625                 630                 635                 640 


Gly Ser Met Ser Gly Leu Gly Cys 
                645             


<210>  116
<211>  1945
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ELP1-120 CatK CNP37 fusion PE9486

<400>  116
atggtaccgg gcgtgggtgt tccgggcgtg ggtgttccgg gtggcggtgt gccgggcgca       60

ggtgttcctg gtgtaggtgt gccgggtgtt ggtgtgccgg gtgttggtgt accaggtggc      120

ggtgttccgg gtgcaggcgt tccgggtggc ggtgtgccgg gcgtgggtgt tccgggcgtg      180

ggtgttccgg gtggcggtgt gccgggcgca ggtgttcctg gtgtaggtgt gccgggtgtt      240

ggtgtgccgg gtgttggtgt accaggtggc ggtgttccgg gtgcaggcgt tccgggtggc      300

ggtgtgccgg gcgtgggtgt tccgggcgtg ggtgttccgg gtggcggtgt gccgggcgca      360

ggtgttcctg gtgtaggtgt gccgggtgtt ggtgtgccgg gtgttggtgt accaggtggc      420

ggtgttccgg gtgcaggcgt tccgggtggc ggtgtgccgg gcgtgggtgt tccgggcgtg      480

ggtgttccgg gtggcggtgt gccgggcgca ggtgttcctg gtgtaggtgt gccgggtgtt      540

ggtgtgccgg gtgttggtgt accaggtggc ggtgttccgg gtgcaggcgt tccgggtggc      600

ggtgtgccgg gcgtgggtgt tccgggcgtg ggtgttccgg gtggcggtgt gccgggcgca      660

ggtgttcctg gtgtaggtgt gccgggtgtt ggtgtgccgg gtgttggtgt accaggtggc      720

ggtgttccgg gtgcaggcgt tccgggtggc ggtgtgccgg gcgtgggtgt tccgggcgtg      780

ggtgttccgg gtggcggtgt gccgggcgca ggtgttcctg gtgtaggtgt gccgggtgtt      840

ggtgtgccgg gtgttggtgt accaggtggc ggtgttccgg gtgcaggcgt tccgggtggc      900

ggtgtgccgg gcgtgggtgt tccgggcgtg ggtgttccgg gtggcggtgt gccgggcgca      960

ggtgttcctg gtgtaggtgt gccgggtgtt ggtgtgccgg gtgttggtgt accaggtggc     1020

ggtgttccgg gtgcaggcgt tccgggtggc ggtgtgccgg gcgtgggtgt tccgggcgtg     1080

ggtgttccgg gtggcggtgt gccgggcgca ggtgttcctg gtgtaggtgt gccgggtgtt     1140

ggtgtgccgg gtgttggtgt accaggtggc ggtgttccgg gtgcaggcgt tccgggtggc     1200

ggtgtgccgg gcgtgggtgt tccgggcgtg ggtgttccgg gtggcggtgt gccgggcgca     1260

ggtgttcctg gtgtaggtgt gccgggtgtt ggtgtgccgg gtgttggtgt accaggtggc     1320

ggtgttccgg gtgcaggcgt tccgggtggc ggtgtgccgg gcgtgggtgt tccgggcgtg     1380

ggtgttccgg gtggcggtgt gccgggcgca ggtgttcctg gtgtaggtgt gccgggtgtt     1440

ggtgtgccgg gtgttggtgt accaggtggc ggtgttccgg gtgcaggcgt tccgggtggc     1500

ggtgtgccgg gcgtgggtgt tccgggcgtg ggtgttccgg gtggcggtgt gccgggcgca     1560

ggtgttcctg gtgtaggtgt gccgggtgtt ggtgtgccgg gtgttggtgt accaggtggc     1620

ggtgttccgg gtgcaggcgt tccgggtggc ggtgtgccgg gcgtgggtgt tccgggcgtg     1680

ggtgttccgg gtggcggtgt gccgggcgca ggtgttcctg gtgtaggtgt gccgggtgtt     1740

ggtgtgccgg gtgttggtgt accaggtggc ggtgttccgg gtgcaggcgt tccgggtggc     1800

ggtgtgccgg gctggccgcc gcaaaccgcg cggtcaggaa catccgaacg cgcgtaaata     1860

taaaggtgcg aacaaaaaag gcctgagcaa aggctgcttt ggcctgaaac tggatcgcat     1920

tggcagcatg agcggcctgg gctgc                                           1945


<210>  117
<211>  664
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  ELP1-120 CatK CNP53 fusion PE9496

<400>  117

Met Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly 
1               5                   10                  15      


Val Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val 
            20                  25                  30          


Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro 
        35                  40                  45              


Gly Gly Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly 
    50                  55                  60                  


Gly Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro Gly Val 
65                  70                  75                  80  


Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly 
                85                  90                  95      


Val Pro Gly Gly Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val 
            100                 105                 110         


Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro 
        115                 120                 125             


Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly 
    130                 135                 140                 


Ala Gly Val Pro Gly Gly Gly Val Pro Gly Val Gly Val Pro Gly Val 
145                 150                 155                 160 


Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly 
                165                 170                 175     


Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val 
            180                 185                 190         


Pro Gly Ala Gly Val Pro Gly Gly Gly Val Pro Gly Val Gly Val Pro 
        195                 200                 205             


Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly 
    210                 215                 220                 


Val Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly 
225                 230                 235                 240 


Gly Val Pro Gly Ala Gly Val Pro Gly Gly Gly Val Pro Gly Val Gly 
                245                 250                 255     


Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val 
            260                 265                 270         


Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro 
        275                 280                 285             


Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Gly Gly Val Pro Gly 
    290                 295                 300                 


Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala 
305                 310                 315                 320 


Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Val Gly 
                325                 330                 335     


Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Gly Gly Val 
            340                 345                 350         


Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro 
        355                 360                 365             


Gly Ala Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly 
    370                 375                 380                 


Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Gly 
385                 390                 395                 400 


Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly 
                405                 410                 415     


Val Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val 
            420                 425                 430         


Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro 
        435                 440                 445             


Gly Gly Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly 
    450                 455                 460                 


Gly Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro Gly Val 
465                 470                 475                 480 


Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly 
                485                 490                 495     


Val Pro Gly Gly Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val 
            500                 505                 510         


Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro 
        515                 520                 525             


Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly 
    530                 535                 540                 


Ala Gly Val Pro Gly Gly Gly Val Pro Gly Val Gly Val Pro Gly Val 
545                 550                 555                 560 


Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly 
                565                 570                 575     


Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val 
            580                 585                 590         


Pro Gly Ala Gly Val Pro Gly Gly Gly Val Pro Gly Trp Pro Arg Lys 
        595                 600                 605             


Pro Arg Gly Asp Leu Arg Val Asp Thr Lys Ser Arg Ala Ala Trp Ala 
    610                 615                 620                 


Arg Leu Leu Gln Glu His Pro Asn Ala Arg Lys Tyr Lys Gly Ala Asn 
625                 630                 635                 640 


Lys Lys Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile 
                645                 650                 655     


Gly Ser Met Ser Gly Leu Gly Cys 
            660                 


<210>  118
<211>  1993
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ELP1-120 CatK CNP53 fusion PE9496

<400>  118
atggtaccgg gcgtgggtgt tccgggcgtg ggtgttccgg gtggcggtgt gccgggcgca       60

ggtgttcctg gtgtaggtgt gccgggtgtt ggtgtgccgg gtgttggtgt accaggtggc      120

ggtgttccgg gtgcaggcgt tccgggtggc ggtgtgccgg gcgtgggtgt tccgggcgtg      180

ggtgttccgg gtggcggtgt gccgggcgca ggtgttcctg gtgtaggtgt gccgggtgtt      240

ggtgtgccgg gtgttggtgt accaggtggc ggtgttccgg gtgcaggcgt tccgggtggc      300

ggtgtgccgg gcgtgggtgt tccgggcgtg ggtgttccgg gtggcggtgt gccgggcgca      360

ggtgttcctg gtgtaggtgt gccgggtgtt ggtgtgccgg gtgttggtgt accaggtggc      420

ggtgttccgg gtgcaggcgt tccgggtggc ggtgtgccgg gcgtgggtgt tccgggcgtg      480

ggtgttccgg gtggcggtgt gccgggcgca ggtgttcctg gtgtaggtgt gccgggtgtt      540

ggtgtgccgg gtgttggtgt accaggtggc ggtgttccgg gtgcaggcgt tccgggtggc      600

ggtgtgccgg gcgtgggtgt tccgggcgtg ggtgttccgg gtggcggtgt gccgggcgca      660

ggtgttcctg gtgtaggtgt gccgggtgtt ggtgtgccgg gtgttggtgt accaggtggc      720

ggtgttccgg gtgcaggcgt tccgggtggc ggtgtgccgg gcgtgggtgt tccgggcgtg      780

ggtgttccgg gtggcggtgt gccgggcgca ggtgttcctg gtgtaggtgt gccgggtgtt      840

ggtgtgccgg gtgttggtgt accaggtggc ggtgttccgg gtgcaggcgt tccgggtggc      900

ggtgtgccgg gcgtgggtgt tccgggcgtg ggtgttccgg gtggcggtgt gccgggcgca      960

ggtgttcctg gtgtaggtgt gccgggtgtt ggtgtgccgg gtgttggtgt accaggtggc     1020

ggtgttccgg gtgcaggcgt tccgggtggc ggtgtgccgg gcgtgggtgt tccgggcgtg     1080

ggtgttccgg gtggcggtgt gccgggcgca ggtgttcctg gtgtaggtgt gccgggtgtt     1140

ggtgtgccgg gtgttggtgt accaggtggc ggtgttccgg gtgcaggcgt tccgggtggc     1200

ggtgtgccgg gcgtgggtgt tccgggcgtg ggtgttccgg gtggcggtgt gccgggcgca     1260

ggtgttcctg gtgtaggtgt gccgggtgtt ggtgtgccgg gtgttggtgt accaggtggc     1320

ggtgttccgg gtgcaggcgt tccgggtggc ggtgtgccgg gcgtgggtgt tccgggcgtg     1380

ggtgttccgg gtggcggtgt gccgggcgca ggtgttcctg gtgtaggtgt gccgggtgtt     1440

ggtgtgccgg gtgttggtgt accaggtggc ggtgttccgg gtgcaggcgt tccgggtggc     1500

ggtgtgccgg gcgtgggtgt tccgggcgtg ggtgttccgg gtggcggtgt gccgggcgca     1560

ggtgttcctg gtgtaggtgt gccgggtgtt ggtgtgccgg gtgttggtgt accaggtggc     1620

ggtgttccgg gtgcaggcgt tccgggtggc ggtgtgccgg gcgtgggtgt tccgggcgtg     1680

ggtgttccgg gtggcggtgt gccgggcgca ggtgttcctg gtgtaggtgt gccgggtgtt     1740

ggtgtgccgg gtgttggtgt accaggtggc ggtgttccgg gtgcaggcgt tccgggtggc     1800

ggtgtgccgg gctggccgcc gcaaaccgcg cggtgatctg cgcgtggata ccaaaagccg     1860

cgcggcgtgg gcgcgcctgc tgcaggaaca tccgaacgcg cgcaaatata aaggcgcgaa     1920

caaaaaaggc ctgagcaaag gctgctttgg cctgaaactg gatcgcattg gcagcatgag     1980

cggcctgggc tgc                                                        1993


<210>  119
<211>  633
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ELP1-120 CatK CNP22 fusion PE9506

<400>  119

Met Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly 
1               5                   10                  15      


Val Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val 
            20                  25                  30          


Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro 
        35                  40                  45              


Gly Gly Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly 
    50                  55                  60                  


Gly Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro Gly Val 
65                  70                  75                  80  


Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly 
                85                  90                  95      


Val Pro Gly Gly Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val 
            100                 105                 110         


Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro 
        115                 120                 125             


Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly 
    130                 135                 140                 


Ala Gly Val Pro Gly Gly Gly Val Pro Gly Val Gly Val Pro Gly Val 
145                 150                 155                 160 


Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly 
                165                 170                 175     


Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val 
            180                 185                 190         


Pro Gly Ala Gly Val Pro Gly Gly Gly Val Pro Gly Val Gly Val Pro 
        195                 200                 205             


Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly 
    210                 215                 220                 


Val Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly 
225                 230                 235                 240 


Gly Val Pro Gly Ala Gly Val Pro Gly Gly Gly Val Pro Gly Val Gly 
                245                 250                 255     


Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val 
            260                 265                 270         


Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro 
        275                 280                 285             


Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Gly Gly Val Pro Gly 
    290                 295                 300                 


Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala 
305                 310                 315                 320 


Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Val Gly 
                325                 330                 335     


Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Gly Gly Val 
            340                 345                 350         


Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro 
        355                 360                 365             


Gly Ala Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly 
    370                 375                 380                 


Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Gly 
385                 390                 395                 400 


Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly 
                405                 410                 415     


Val Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val 
            420                 425                 430         


Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro 
        435                 440                 445             


Gly Gly Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly 
    450                 455                 460                 


Gly Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro Gly Val 
465                 470                 475                 480 


Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly 
                485                 490                 495     


Val Pro Gly Gly Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val 
            500                 505                 510         


Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro 
        515                 520                 525             


Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly 
    530                 535                 540                 


Ala Gly Val Pro Gly Gly Gly Val Pro Gly Val Gly Val Pro Gly Val 
545                 550                 555                 560 


Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly 
                565                 570                 575     


Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val 
            580                 585                 590         


Pro Gly Ala Gly Val Pro Gly Gly Gly Val Pro Gly Trp Pro Arg Lys 
        595                 600                 605             


Pro Arg Gly Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg 
    610                 615                 620                 


Ile Gly Ser Met Ser Gly Leu Gly Cys 
625                 630             


<210>  120
<211>  1900
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ELP1-120 CatK CNP22 fusion PE9506

<400>  120
atggtaccgg gcgtgggtgt tccgggcgtg ggtgttccgg gtggcggtgt gccgggcgca       60

ggtgttcctg gtgtaggtgt gccgggtgtt ggtgtgccgg gtgttggtgt accaggtggc      120

ggtgttccgg gtgcaggcgt tccgggtggc ggtgtgccgg gcgtgggtgt tccgggcgtg      180

ggtgttccgg gtggcggtgt gccgggcgca ggtgttcctg gtgtaggtgt gccgggtgtt      240

ggtgtgccgg gtgttggtgt accaggtggc ggtgttccgg gtgcaggcgt tccgggtggc      300

ggtgtgccgg gcgtgggtgt tccgggcgtg ggtgttccgg gtggcggtgt gccgggcgca      360

ggtgttcctg gtgtaggtgt gccgggtgtt ggtgtgccgg gtgttggtgt accaggtggc      420

ggtgttccgg gtgcaggcgt tccgggtggc ggtgtgccgg gcgtgggtgt tccgggcgtg      480

ggtgttccgg gtggcggtgt gccgggcgca ggtgttcctg gtgtaggtgt gccgggtgtt      540

ggtgtgccgg gtgttggtgt accaggtggc ggtgttccgg gtgcaggcgt tccgggtggc      600

ggtgtgccgg gcgtgggtgt tccgggcgtg ggtgttccgg gtggcggtgt gccgggcgca      660

ggtgttcctg gtgtaggtgt gccgggtgtt ggtgtgccgg gtgttggtgt accaggtggc      720

ggtgttccgg gtgcaggcgt tccgggtggc ggtgtgccgg gcgtgggtgt tccgggcgtg      780

ggtgttccgg gtggcggtgt gccgggcgca ggtgttcctg gtgtaggtgt gccgggtgtt      840

ggtgtgccgg gtgttggtgt accaggtggc ggtgttccgg gtgcaggcgt tccgggtggc      900

ggtgtgccgg gcgtgggtgt tccgggcgtg ggtgttccgg gtggcggtgt gccgggcgca      960

ggtgttcctg gtgtaggtgt gccgggtgtt ggtgtgccgg gtgttggtgt accaggtggc     1020

ggtgttccgg gtgcaggcgt tccgggtggc ggtgtgccgg gcgtgggtgt tccgggcgtg     1080

ggtgttccgg gtggcggtgt gccgggcgca ggtgttcctg gtgtaggtgt gccgggtgtt     1140

ggtgtgccgg gtgttggtgt accaggtggc ggtgttccgg gtgcaggcgt tccgggtggc     1200

ggtgtgccgg gcgtgggtgt tccgggcgtg ggtgttccgg gtggcggtgt gccgggcgca     1260

ggtgttcctg gtgtaggtgt gccgggtgtt ggtgtgccgg gtgttggtgt accaggtggc     1320

ggtgttccgg gtgcaggcgt tccgggtggc ggtgtgccgg gcgtgggtgt tccgggcgtg     1380

ggtgttccgg gtggcggtgt gccgggcgca ggtgttcctg gtgtaggtgt gccgggtgtt     1440

ggtgtgccgg gtgttggtgt accaggtggc ggtgttccgg gtgcaggcgt tccgggtggc     1500

ggtgtgccgg gcgtgggtgt tccgggcgtg ggtgttccgg gtggcggtgt gccgggcgca     1560

ggtgttcctg gtgtaggtgt gccgggtgtt ggtgtgccgg gtgttggtgt accaggtggc     1620

ggtgttccgg gtgcaggcgt tccgggtggc ggtgtgccgg gcgtgggtgt tccgggcgtg     1680

ggtgttccgg gtggcggtgt gccgggcgca ggtgttcctg gtgtaggtgt gccgggtgtt     1740

ggtgtgccgg gtgttggtgt accaggtggc ggtgttccgg gtgcaggcgt tccgggtggc     1800

ggtgtgccgg gctggccgcc gcaaaccgcg cggtggcctg agcaaaggct gctttggcct     1860

gaaactggat cgcattggca gcatgagcgg cctgggctgc                           1900


<210>  121
<211>  647
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CNP37 Fxa ELP1-120 fusion PE9206

<400>  121

Gln Glu His Pro Asn Ala Arg Lys Tyr Lys Gly Ala Asn Lys Lys Gly 
1               5                   10                  15      


Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser Met 
            20                  25                  30          


Ser Gly Leu Gly Cys Ile Glu Gly Arg Gly Val Pro Gly Val Gly Val 
        35                  40                  45              


Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro 
    50                  55                  60                  


Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly 
65                  70                  75                  80  


Gly Gly Val Pro Gly Ala Gly Val Pro Gly Gly Gly Val Pro Gly Val 
                85                  90                  95      


Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly 
            100                 105                 110         


Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val 
        115                 120                 125             


Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Gly Gly Val Pro 
    130                 135                 140                 


Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly 
145                 150                 155                 160 


Ala Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Val 
                165                 170                 175     


Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Gly Gly 
            180                 185                 190         


Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val 
        195                 200                 205             


Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro 
    210                 215                 220                 


Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly 
225                 230                 235                 240 


Gly Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly 
                245                 250                 255     


Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro Gly Val Gly 
            260                 265                 270         


Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val 
        275                 280                 285             


Pro Gly Gly Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro 
    290                 295                 300                 


Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro Gly 
305                 310                 315                 320 


Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala 
                325                 330                 335     


Gly Val Pro Gly Gly Gly Val Pro Gly Val Gly Val Pro Gly Val Gly 
            340                 345                 350         


Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly Val 
        355                 360                 365             


Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro 
    370                 375                 380                 


Gly Ala Gly Val Pro Gly Gly Gly Val Pro Gly Val Gly Val Pro Gly 
385                 390                 395                 400 


Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Val 
                405                 410                 415     


Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly 
            420                 425                 430         


Val Pro Gly Ala Gly Val Pro Gly Gly Gly Val Pro Gly Val Gly Val 
        435                 440                 445             


Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro 
    450                 455                 460                 


Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly 
465                 470                 475                 480 


Gly Gly Val Pro Gly Ala Gly Val Pro Gly Gly Gly Val Pro Gly Val 
                485                 490                 495     


Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly 
            500                 505                 510         


Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val 
        515                 520                 525             


Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Gly Gly Val Pro 
    530                 535                 540                 


Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly 
545                 550                 555                 560 


Ala Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Val 
                565                 570                 575     


Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Gly Gly 
            580                 585                 590         


Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val 
        595                 600                 605             


Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro 
    610                 615                 620                 


Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly 
625                 630                 635                 640 


Gly Gly Val Pro Gly Trp Pro 
                645         


<210>  122
<211>  1941
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CNP37 Fxa ELP1-120 fusion PE9206

<400>  122
caggaacatc cgaacgcgcg taaatataaa ggtgcgaaca aaaaaggcct gagcaaaggc       60

tgctttggcc tgaaactgga tcgcattggc agcatgagcg gcctgggctg cattgaaggc      120

cgcggtgtac cgggcgtggg tgttccgggc gtgggtgttc cgggtggcgg tgtgccgggc      180

gcaggtgttc ctggtgtagg tgtgccgggt gttggtgtgc cgggtgttgg tgtaccaggt      240

ggcggtgttc cgggtgcagg cgttccgggt ggcggtgtgc cgggcgtggg tgttccgggc      300

gtgggtgttc cgggtggcgg tgtgccgggc gcaggtgttc ctggtgtagg tgtgccgggt      360

gttggtgtgc cgggtgttgg tgtaccaggt ggcggtgttc cgggtgcagg cgttccgggt      420

ggcggtgtgc cgggcgtggg tgttccgggc gtgggtgttc cgggtggcgg tgtgccgggc      480

gcaggtgttc ctggtgtagg tgtgccgggt gttggtgtgc cgggtgttgg tgtaccaggt      540

ggcggtgttc cgggtgcagg cgttccgggt ggcggtgtgc cgggcgtggg tgttccgggc      600

gtgggtgttc cgggtggcgg tgtgccgggc gcaggtgttc ctggtgtagg tgtgccgggt      660

gttggtgtgc cgggtgttgg tgtaccaggt ggcggtgttc cgggtgcagg cgttccgggt      720

ggcggtgtgc cgggcgtggg tgttccgggc gtgggtgttc cgggtggcgg tgtgccgggc      780

gcaggtgttc ctggtgtagg tgtgccgggt gttggtgtgc cgggtgttgg tgtaccaggt      840

ggcggtgttc cgggtgcagg cgttccgggt ggcggtgtgc cgggcgtggg tgttccgggc      900

gtgggtgttc cgggtggcgg tgtgccgggc gcaggtgttc ctggtgtagg tgtgccgggt      960

gttggtgtgc cgggtgttgg tgtaccaggt ggcggtgttc cgggtgcagg cgttccgggt     1020

ggcggtgtgc cgggcgtggg tgttccgggc gtgggtgttc cgggtggcgg tgtgccgggc     1080

gcaggtgttc ctggtgtagg tgtgccgggt gttggtgtgc cgggtgttgg tgtaccaggt     1140

ggcggtgttc cgggtgcagg cgttccgggt ggcggtgtgc cgggcgtggg tgttccgggc     1200

gtgggtgttc cgggtggcgg tgtgccgggc gcaggtgttc ctggtgtagg tgtgccgggt     1260

gttggtgtgc cgggtgttgg tgtaccaggt ggcggtgttc cgggtgcagg cgttccgggt     1320

ggcggtgtgc cgggcgtggg tgttccgggc gtgggtgttc cgggtggcgg tgtgccgggc     1380

gcaggtgttc ctggtgtagg tgtgccgggt gttggtgtgc cgggtgttgg tgtaccaggt     1440

ggcggtgttc cgggtgcagg cgttccgggt ggcggtgtgc cgggcgtggg tgttccgggc     1500

gtgggtgttc cgggtggcgg tgtgccgggc gcaggtgttc ctggtgtagg tgtgccgggt     1560

gttggtgtgc cgggtgttgg tgtaccaggt ggcggtgttc cgggtgcagg cgttccgggt     1620

ggcggtgtgc cgggcgtggg tgttccgggc gtgggtgttc cgggtggcgg tgtgccgggc     1680

gcaggtgttc ctggtgtagg tgtgccgggt gttggtgtgc cgggtgttgg tgtaccaggt     1740

ggcggtgttc cgggtgcagg cgttccgggt ggcggtgtgc cgggcgtggg tgttccgggc     1800

gtgggtgttc cgggtggcgg tgtgccgggc gcaggtgttc ctggtgtagg tgtgccgggt     1860

gttggtgtgc cgggtgttgg tgtaccaggt ggcggtgttc cgggtgcagg cgttccgggt     1920

ggcggtgtgc cgggctggcc g                                               1941


<210>  123
<211>  649
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CNP37 thrombin ELP1-120 fusion PE9216

<400>  123

Gln Glu His Pro Asn Ala Arg Lys Tyr Lys Gly Ala Asn Lys Lys Gly 
1               5                   10                  15      


Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser Met 
            20                  25                  30          


Ser Gly Leu Gly Cys Leu Val Pro Arg Gly Ser Gly Val Pro Gly Val 
        35                  40                  45              


Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly 
    50                  55                  60                  


Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val 
65                  70                  75                  80  


Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Gly Gly Val Pro 
                85                  90                  95      


Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly 
            100                 105                 110         


Ala Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Val 
        115                 120                 125             


Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Gly Gly 
    130                 135                 140                 


Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val 
145                 150                 155                 160 


Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro 
                165                 170                 175     


Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly 
            180                 185                 190         


Gly Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly 
        195                 200                 205             


Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro Gly Val Gly 
    210                 215                 220                 


Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val 
225                 230                 235                 240 


Pro Gly Gly Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro 
                245                 250                 255     


Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro Gly 
            260                 265                 270         


Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala 
        275                 280                 285             


Gly Val Pro Gly Gly Gly Val Pro Gly Val Gly Val Pro Gly Val Gly 
    290                 295                 300                 


Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly Val 
305                 310                 315                 320 


Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro 
                325                 330                 335     


Gly Ala Gly Val Pro Gly Gly Gly Val Pro Gly Val Gly Val Pro Gly 
            340                 345                 350         


Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Val 
        355                 360                 365             


Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly 
    370                 375                 380                 


Val Pro Gly Ala Gly Val Pro Gly Gly Gly Val Pro Gly Val Gly Val 
385                 390                 395                 400 


Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro 
                405                 410                 415     


Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly 
            420                 425                 430         


Gly Gly Val Pro Gly Ala Gly Val Pro Gly Gly Gly Val Pro Gly Val 
        435                 440                 445             


Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly 
    450                 455                 460                 


Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val 
465                 470                 475                 480 


Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Gly Gly Val Pro 
                485                 490                 495     


Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly 
            500                 505                 510         


Ala Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Val 
        515                 520                 525             


Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Gly Gly 
    530                 535                 540                 


Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val 
545                 550                 555                 560 


Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro 
                565                 570                 575     


Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly 
            580                 585                 590         


Gly Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly 
        595                 600                 605             


Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro Gly Val Gly 
    610                 615                 620                 


Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val 
625                 630                 635                 640 


Pro Gly Gly Gly Val Pro Gly Trp Pro 
                645                 


<210>  124
<211>  1947
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CNP37 thrombin ELP1-120 fusion PE9216

<400>  124
caggaacatc cgaacgcgcg taaatataaa ggtgcgaaca aaaaaggcct gagcaaaggc       60

tgctttggcc tgaaactgga tcgcattggc agcatgagcg gcctgggctg cctggtgccg      120

cgcggcagcg gtgtaccggg cgtgggtgtt ccgggcgtgg gtgttccggg tggcggtgtg      180

ccgggcgcag gtgttcctgg tgtaggtgtg ccgggtgttg gtgtgccggg tgttggtgta      240

ccaggtggcg gtgttccggg tgcaggcgtt ccgggtggcg gtgtgccggg cgtgggtgtt      300

ccgggcgtgg gtgttccggg tggcggtgtg ccgggcgcag gtgttcctgg tgtaggtgtg      360

ccgggtgttg gtgtgccggg tgttggtgta ccaggtggcg gtgttccggg tgcaggcgtt      420

ccgggtggcg gtgtgccggg cgtgggtgtt ccgggcgtgg gtgttccggg tggcggtgtg      480

ccgggcgcag gtgttcctgg tgtaggtgtg ccgggtgttg gtgtgccggg tgttggtgta      540

ccaggtggcg gtgttccggg tgcaggcgtt ccgggtggcg gtgtgccggg cgtgggtgtt      600

ccgggcgtgg gtgttccggg tggcggtgtg ccgggcgcag gtgttcctgg tgtaggtgtg      660

ccgggtgttg gtgtgccggg tgttggtgta ccaggtggcg gtgttccggg tgcaggcgtt      720

ccgggtggcg gtgtgccggg cgtgggtgtt ccgggcgtgg gtgttccggg tggcggtgtg      780

ccgggcgcag gtgttcctgg tgtaggtgtg ccgggtgttg gtgtgccggg tgttggtgta      840

ccaggtggcg gtgttccggg tgcaggcgtt ccgggtggcg gtgtgccggg cgtgggtgtt      900

ccgggcgtgg gtgttccggg tggcggtgtg ccgggcgcag gtgttcctgg tgtaggtgtg      960

ccgggtgttg gtgtgccggg tgttggtgta ccaggtggcg gtgttccggg tgcaggcgtt     1020

ccgggtggcg gtgtgccggg cgtgggtgtt ccgggcgtgg gtgttccggg tggcggtgtg     1080

ccgggcgcag gtgttcctgg tgtaggtgtg ccgggtgttg gtgtgccggg tgttggtgta     1140

ccaggtggcg gtgttccggg tgcaggcgtt ccgggtggcg gtgtgccggg cgtgggtgtt     1200

ccgggcgtgg gtgttccggg tggcggtgtg ccgggcgcag gtgttcctgg tgtaggtgtg     1260

ccgggtgttg gtgtgccggg tgttggtgta ccaggtggcg gtgttccggg tgcaggcgtt     1320

ccgggtggcg gtgtgccggg cgtgggtgtt ccgggcgtgg gtgttccggg tggcggtgtg     1380

ccgggcgcag gtgttcctgg tgtaggtgtg ccgggtgttg gtgtgccggg tgttggtgta     1440

ccaggtggcg gtgttccggg tgcaggcgtt ccgggtggcg gtgtgccggg cgtgggtgtt     1500

ccgggcgtgg gtgttccggg tggcggtgtg ccgggcgcag gtgttcctgg tgtaggtgtg     1560

ccgggtgttg gtgtgccggg tgttggtgta ccaggtggcg gtgttccggg tgcaggcgtt     1620

ccgggtggcg gtgtgccggg cgtgggtgtt ccgggcgtgg gtgttccggg tggcggtgtg     1680

ccgggcgcag gtgttcctgg tgtaggtgtg ccgggtgttg gtgtgccggg tgttggtgta     1740

ccaggtggcg gtgttccggg tgcaggcgtt ccgggtggcg gtgtgccggg cgtgggtgtt     1800

ccgggcgtgg gtgttccggg tggcggtgtg ccgggcgcag gtgttcctgg tgtaggtgtg     1860

ccgggtgttg gtgtgccggg tgttggtgta ccaggtggcg gtgttccggg tgcaggcgtt     1920

ccgggtggcg gtgtgccggg ctggccg                                         1947


<210>  125
<211>  647
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CNP37 CatK ELP1-120 fusion PE9306

<400>  125

Gln Glu His Pro Asn Ala Arg Lys Tyr Lys Gly Ala Asn Lys Lys Gly 
1               5                   10                  15      


Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser Met 
            20                  25                  30          


Ser Gly Leu Gly Cys Arg Lys Pro Arg Gly Val Pro Gly Val Gly Val 
        35                  40                  45              


Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro 
    50                  55                  60                  


Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly 
65                  70                  75                  80  


Gly Gly Val Pro Gly Ala Gly Val Pro Gly Gly Gly Val Pro Gly Val 
                85                  90                  95      


Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly 
            100                 105                 110         


Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val 
        115                 120                 125             


Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Gly Gly Val Pro 
    130                 135                 140                 


Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly 
145                 150                 155                 160 


Ala Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Val 
                165                 170                 175     


Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Gly Gly 
            180                 185                 190         


Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val 
        195                 200                 205             


Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro 
    210                 215                 220                 


Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly 
225                 230                 235                 240 


Gly Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly 
                245                 250                 255     


Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro Gly Val Gly 
            260                 265                 270         


Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val 
        275                 280                 285             


Pro Gly Gly Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro 
    290                 295                 300                 


Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro Gly 
305                 310                 315                 320 


Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala 
                325                 330                 335     


Gly Val Pro Gly Gly Gly Val Pro Gly Val Gly Val Pro Gly Val Gly 
            340                 345                 350         


Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly Val 
        355                 360                 365             


Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro 
    370                 375                 380                 


Gly Ala Gly Val Pro Gly Gly Gly Val Pro Gly Val Gly Val Pro Gly 
385                 390                 395                 400 


Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Val 
                405                 410                 415     


Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly 
            420                 425                 430         


Val Pro Gly Ala Gly Val Pro Gly Gly Gly Val Pro Gly Val Gly Val 
        435                 440                 445             


Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro 
    450                 455                 460                 


Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly 
465                 470                 475                 480 


Gly Gly Val Pro Gly Ala Gly Val Pro Gly Gly Gly Val Pro Gly Val 
                485                 490                 495     


Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly 
            500                 505                 510         


Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val 
        515                 520                 525             


Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Gly Gly Val Pro 
    530                 535                 540                 


Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly 
545                 550                 555                 560 


Ala Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Val 
                565                 570                 575     


Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Gly Gly 
            580                 585                 590         


Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val 
        595                 600                 605             


Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro 
    610                 615                 620                 


Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly 
625                 630                 635                 640 


Gly Gly Val Pro Gly Trp Pro 
                645         


<210>  126
<211>  1941
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CNP37 CatK ELP1-120 fusion PE9306

<400>  126
caggaacatc cgaacgcgcg taaatataaa ggtgcgaaca aaaaaggcct gagcaaaggc       60

tgctttggcc tgaaactgga tcgcattggc agcatgagcg gcctgggctg ccgcaaaccg      120

cgcggtgtac cgggcgtggg tgttccgggc gtgggtgttc cgggtggcgg tgtgccgggc      180

gcaggtgttc ctggtgtagg tgtgccgggt gttggtgtgc cgggtgttgg tgtaccaggt      240

ggcggtgttc cgggtgcagg cgttccgggt ggcggtgtgc cgggcgtggg tgttccgggc      300

gtgggtgttc cgggtggcgg tgtgccgggc gcaggtgttc ctggtgtagg tgtgccgggt      360

gttggtgtgc cgggtgttgg tgtaccaggt ggcggtgttc cgggtgcagg cgttccgggt      420

ggcggtgtgc cgggcgtggg tgttccgggc gtgggtgttc cgggtggcgg tgtgccgggc      480

gcaggtgttc ctggtgtagg tgtgccgggt gttggtgtgc cgggtgttgg tgtaccaggt      540

ggcggtgttc cgggtgcagg cgttccgggt ggcggtgtgc cgggcgtggg tgttccgggc      600

gtgggtgttc cgggtggcgg tgtgccgggc gcaggtgttc ctggtgtagg tgtgccgggt      660

gttggtgtgc cgggtgttgg tgtaccaggt ggcggtgttc cgggtgcagg cgttccgggt      720

ggcggtgtgc cgggcgtggg tgttccgggc gtgggtgttc cgggtggcgg tgtgccgggc      780

gcaggtgttc ctggtgtagg tgtgccgggt gttggtgtgc cgggtgttgg tgtaccaggt      840

ggcggtgttc cgggtgcagg cgttccgggt ggcggtgtgc cgggcgtggg tgttccgggc      900

gtgggtgttc cgggtggcgg tgtgccgggc gcaggtgttc ctggtgtagg tgtgccgggt      960

gttggtgtgc cgggtgttgg tgtaccaggt ggcggtgttc cgggtgcagg cgttccgggt     1020

ggcggtgtgc cgggcgtggg tgttccgggc gtgggtgttc cgggtggcgg tgtgccgggc     1080

gcaggtgttc ctggtgtagg tgtgccgggt gttggtgtgc cgggtgttgg tgtaccaggt     1140

ggcggtgttc cgggtgcagg cgttccgggt ggcggtgtgc cgggcgtggg tgttccgggc     1200

gtgggtgttc cgggtggcgg tgtgccgggc gcaggtgttc ctggtgtagg tgtgccgggt     1260

gttggtgtgc cgggtgttgg tgtaccaggt ggcggtgttc cgggtgcagg cgttccgggt     1320

ggcggtgtgc cgggcgtggg tgttccgggc gtgggtgttc cgggtggcgg tgtgccgggc     1380

gcaggtgttc ctggtgtagg tgtgccgggt gttggtgtgc cgggtgttgg tgtaccaggt     1440

ggcggtgttc cgggtgcagg cgttccgggt ggcggtgtgc cgggcgtggg tgttccgggc     1500

gtgggtgttc cgggtggcgg tgtgccgggc gcaggtgttc ctggtgtagg tgtgccgggt     1560

gttggtgtgc cgggtgttgg tgtaccaggt ggcggtgttc cgggtgcagg cgttccgggt     1620

ggcggtgtgc cgggcgtggg tgttccgggc gtgggtgttc cgggtggcgg tgtgccgggc     1680

gcaggtgttc ctggtgtagg tgtgccgggt gttggtgtgc cgggtgttgg tgtaccaggt     1740

ggcggtgttc cgggtgcagg cgttccgggt ggcggtgtgc cgggcgtggg tgttccgggc     1800

gtgggtgttc cgggtggcgg tgtgccgggc gcaggtgttc ctggtgtagg tgtgccgggt     1860

gttggtgtgc cgggtgttgg tgtaccaggt ggcggtgttc cgggtgcagg cgttccgggt     1920

ggcggtgtgc cgggctggcc g                                               1941


<210>  127
<211>  647
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CNP37 CatK ELP1-120 fusion PE9316

<400>  127

Gln Glu His Pro Asn Ala Arg Lys Tyr Lys Gly Ala Asn Lys Lys Gly 
1               5                   10                  15      


Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser Met 
            20                  25                  30          


Ser Gly Leu Gly Cys Arg Lys Pro Arg Gly Val Pro Gly Val Gly Val 
        35                  40                  45              


Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro 
    50                  55                  60                  


Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly 
65                  70                  75                  80  


Gly Gly Val Pro Gly Ala Gly Val Pro Gly Gly Gly Val Pro Gly Val 
                85                  90                  95      


Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly 
            100                 105                 110         


Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val 
        115                 120                 125             


Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Gly Gly Val Pro 
    130                 135                 140                 


Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly 
145                 150                 155                 160 


Ala Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Val 
                165                 170                 175     


Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Gly Gly 
            180                 185                 190         


Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val 
        195                 200                 205             


Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro 
    210                 215                 220                 


Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly 
225                 230                 235                 240 


Gly Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly 
                245                 250                 255     


Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro Gly Val Gly 
            260                 265                 270         


Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val 
        275                 280                 285             


Pro Gly Gly Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro 
    290                 295                 300                 


Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro Gly 
305                 310                 315                 320 


Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala 
                325                 330                 335     


Gly Val Pro Gly Gly Gly Val Pro Gly Val Gly Val Pro Gly Val Gly 
            340                 345                 350         


Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly Val 
        355                 360                 365             


Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro 
    370                 375                 380                 


Gly Ala Gly Val Pro Gly Gly Gly Val Pro Gly Val Gly Val Pro Gly 
385                 390                 395                 400 


Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Val 
                405                 410                 415     


Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly 
            420                 425                 430         


Val Pro Gly Ala Gly Val Pro Gly Gly Gly Val Pro Gly Val Gly Val 
        435                 440                 445             


Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro 
    450                 455                 460                 


Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly 
465                 470                 475                 480 


Gly Gly Val Pro Gly Ala Gly Val Pro Gly Gly Gly Val Pro Gly Val 
                485                 490                 495     


Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly 
            500                 505                 510         


Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val 
        515                 520                 525             


Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Gly Gly Val Pro 
    530                 535                 540                 


Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly 
545                 550                 555                 560 


Ala Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Val 
                565                 570                 575     


Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Gly Gly 
            580                 585                 590         


Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val 
        595                 600                 605             


Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro 
    610                 615                 620                 


Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly 
625                 630                 635                 640 


Gly Gly Val Pro Gly Trp Pro 
                645         


<210>  128
<211>  1941
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CNP37 CatK ELP1-120 fusion PE9316

<400>  128
caggaacatc cgaacgcgcg taaatataaa ggtgcgaaca aaaaaggcct gagcaaaggc       60

tgctttggcc tgaaactgga tcgcattggc agcatgagcg gcctgggctg ccgcaaaccg      120

cgcggtgtac cgggcgtggg tgttccgggc gtgggtgttc cgggtggcgg tgtgccgggc      180

gcaggtgttc ctggtgtagg tgtgccgggt gttggtgtgc cgggtgttgg tgtaccaggt      240

ggcggtgttc cgggtgcagg cgttccgggt ggcggtgtgc cgggcgtggg tgttccgggc      300

gtgggtgttc cgggtggcgg tgtgccgggc gcaggtgttc ctggtgtagg tgtgccgggt      360

gttggtgtgc cgggtgttgg tgtaccaggt ggcggtgttc cgggtgcagg cgttccgggt      420

ggcggtgtgc cgggcgtggg tgttccgggc gtgggtgttc cgggtggcgg tgtgccgggc      480

gcaggtgttc ctggtgtagg tgtgccgggt gttggtgtgc cgggtgttgg tgtaccaggt      540

ggcggtgttc cgggtgcagg cgttccgggt ggcggtgtgc cgggcgtggg tgttccgggc      600

gtgggtgttc cgggtggcgg tgtgccgggc gcaggtgttc ctggtgtagg tgtgccgggt      660

gttggtgtgc cgggtgttgg tgtaccaggt ggcggtgttc cgggtgcagg cgttccgggt      720

ggcggtgtgc cgggcgtggg tgttccgggc gtgggtgttc cgggtggcgg tgtgccgggc      780

gcaggtgttc ctggtgtagg tgtgccgggt gttggtgtgc cgggtgttgg tgtaccaggt      840

ggcggtgttc cgggtgcagg cgttccgggt ggcggtgtgc cgggcgtggg tgttccgggc      900

gtgggtgttc cgggtggcgg tgtgccgggc gcaggtgttc ctggtgtagg tgtgccgggt      960

gttggtgtgc cgggtgttgg tgtaccaggt ggcggtgttc cgggtgcagg cgttccgggt     1020

ggcggtgtgc cgggcgtggg tgttccgggc gtgggtgttc cgggtggcgg tgtgccgggc     1080

gcaggtgttc ctggtgtagg tgtgccgggt gttggtgtgc cgggtgttgg tgtaccaggt     1140

ggcggtgttc cgggtgcagg cgttccgggt ggcggtgtgc cgggcgtggg tgttccgggc     1200

gtgggtgttc cgggtggcgg tgtgccgggc gcaggtgttc ctggtgtagg tgtgccgggt     1260

gttggtgtgc cgggtgttgg tgtaccaggt ggcggtgttc cgggtgcagg cgttccgggt     1320

ggcggtgtgc cgggcgtggg tgttccgggc gtgggtgttc cgggtggcgg tgtgccgggc     1380

gcaggtgttc ctggtgtagg tgtgccgggt gttggtgtgc cgggtgttgg tgtaccaggt     1440

ggcggtgttc cgggtgcagg cgttccgggt ggcggtgtgc cgggcgtggg tgttccgggc     1500

gtgggtgttc cgggtggcgg tgtgccgggc gcaggtgttc ctggtgtagg tgtgccgggt     1560

gttggtgtgc cgggtgttgg tgtaccaggt ggcggtgttc cgggtgcagg cgttccgggt     1620

ggcggtgtgc cgggcgtggg tgttccgggc gtgggtgttc cgggtggcgg tgtgccgggc     1680

gcaggtgttc ctggtgtagg tgtgccgggt gttggtgtgc cgggtgttgg tgtaccaggt     1740

ggcggtgttc cgggtgcagg cgttccgggt ggcggtgtgc cgggcgtggg tgttccgggc     1800

gtgggtgttc cgggtggcgg tgtgccgggc gcaggtgttc ctggtgtagg tgtgccgggt     1860

gttggtgtgc cgggtgttgg tgtaccaggt ggcggtgttc cgggtgcagg cgttccgggt     1920

ggcggtgtgc cgggctggcc g                                               1941


<210>  129
<211>  649
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CNP37 MMP ELP1-120 fusion PE09326

<400>  129

Gln Glu His Pro Asn Ala Arg Lys Tyr Lys Gly Ala Asn Lys Lys Gly 
1               5                   10                  15      


Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser Met 
            20                  25                  30          


Ser Gly Leu Gly Cys Pro Leu Gly Leu Trp Ala Gly Val Pro Gly Val 
        35                  40                  45              


Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly 
    50                  55                  60                  


Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val 
65                  70                  75                  80  


Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Gly Gly Val Pro 
                85                  90                  95      


Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly 
            100                 105                 110         


Ala Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Val 
        115                 120                 125             


Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Gly Gly 
    130                 135                 140                 


Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val 
145                 150                 155                 160 


Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro 
                165                 170                 175     


Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly 
            180                 185                 190         


Gly Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly 
        195                 200                 205             


Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro Gly Val Gly 
    210                 215                 220                 


Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val 
225                 230                 235                 240 


Pro Gly Gly Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro 
                245                 250                 255     


Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro Gly 
            260                 265                 270         


Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala 
        275                 280                 285             


Gly Val Pro Gly Gly Gly Val Pro Gly Val Gly Val Pro Gly Val Gly 
    290                 295                 300                 


Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly Val 
305                 310                 315                 320 


Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro 
                325                 330                 335     


Gly Ala Gly Val Pro Gly Gly Gly Val Pro Gly Val Gly Val Pro Gly 
            340                 345                 350         


Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Val 
        355                 360                 365             


Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly 
    370                 375                 380                 


Val Pro Gly Ala Gly Val Pro Gly Gly Gly Val Pro Gly Val Gly Val 
385                 390                 395                 400 


Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro 
                405                 410                 415     


Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly 
            420                 425                 430         


Gly Gly Val Pro Gly Ala Gly Val Pro Gly Gly Gly Val Pro Gly Val 
        435                 440                 445             


Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly 
    450                 455                 460                 


Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val 
465                 470                 475                 480 


Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Gly Gly Val Pro 
                485                 490                 495     


Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly 
            500                 505                 510         


Ala Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Val 
        515                 520                 525             


Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Gly Gly 
    530                 535                 540                 


Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val 
545                 550                 555                 560 


Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro 
                565                 570                 575     


Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly 
            580                 585                 590         


Gly Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly 
        595                 600                 605             


Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro Gly Val Gly 
    610                 615                 620                 


Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val 
625                 630                 635                 640 


Pro Gly Gly Gly Val Pro Gly Trp Pro 
                645                 


<210>  130
<211>  1947
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CNP37 MMP ELP1-120 fusion PE09326

<400>  130
caggaacatc cgaacgcgcg taaatataaa ggtgcgaaca aaaaaggcct gagcaaaggc       60

tgctttggcc tgaaactgga tcgcattggc agcatgagcg gcctgggctg cccgctgggc      120

ctgtgggcgg gtgtaccggg cgtgggtgtt ccgggcgtgg gtgttccggg tggcggtgtg      180

ccgggcgcag gtgttcctgg tgtaggtgtg ccgggtgttg gtgtgccggg tgttggtgta      240

ccaggtggcg gtgttccggg tgcaggcgtt ccgggtggcg gtgtgccggg cgtgggtgtt      300

ccgggcgtgg gtgttccggg tggcggtgtg ccgggcgcag gtgttcctgg tgtaggtgtg      360

ccgggtgttg gtgtgccggg tgttggtgta ccaggtggcg gtgttccggg tgcaggcgtt      420

ccgggtggcg gtgtgccggg cgtgggtgtt ccgggcgtgg gtgttccggg tggcggtgtg      480

ccgggcgcag gtgttcctgg tgtaggtgtg ccgggtgttg gtgtgccggg tgttggtgta      540

ccaggtggcg gtgttccggg tgcaggcgtt ccgggtggcg gtgtgccggg cgtgggtgtt      600

ccgggcgtgg gtgttccggg tggcggtgtg ccgggcgcag gtgttcctgg tgtaggtgtg      660

ccgggtgttg gtgtgccggg tgttggtgta ccaggtggcg gtgttccggg tgcaggcgtt      720

ccgggtggcg gtgtgccggg cgtgggtgtt ccgggcgtgg gtgttccggg tggcggtgtg      780

ccgggcgcag gtgttcctgg tgtaggtgtg ccgggtgttg gtgtgccggg tgttggtgta      840

ccaggtggcg gtgttccggg tgcaggcgtt ccgggtggcg gtgtgccggg cgtgggtgtt      900

ccgggcgtgg gtgttccggg tggcggtgtg ccgggcgcag gtgttcctgg tgtaggtgtg      960

ccgggtgttg gtgtgccggg tgttggtgta ccaggtggcg gtgttccggg tgcaggcgtt     1020

ccgggtggcg gtgtgccggg cgtgggtgtt ccgggcgtgg gtgttccggg tggcggtgtg     1080

ccgggcgcag gtgttcctgg tgtaggtgtg ccgggtgttg gtgtgccggg tgttggtgta     1140

ccaggtggcg gtgttccggg tgcaggcgtt ccgggtggcg gtgtgccggg cgtgggtgtt     1200

ccgggcgtgg gtgttccggg tggcggtgtg ccgggcgcag gtgttcctgg tgtaggtgtg     1260

ccgggtgttg gtgtgccggg tgttggtgta ccaggtggcg gtgttccggg tgcaggcgtt     1320

ccgggtggcg gtgtgccggg cgtgggtgtt ccgggcgtgg gtgttccggg tggcggtgtg     1380

ccgggcgcag gtgttcctgg tgtaggtgtg ccgggtgttg gtgtgccggg tgttggtgta     1440

ccaggtggcg gtgttccggg tgcaggcgtt ccgggtggcg gtgtgccggg cgtgggtgtt     1500

ccgggcgtgg gtgttccggg tggcggtgtg ccgggcgcag gtgttcctgg tgtaggtgtg     1560

ccgggtgttg gtgtgccggg tgttggtgta ccaggtggcg gtgttccggg tgcaggcgtt     1620

ccgggtggcg gtgtgccggg cgtgggtgtt ccgggcgtgg gtgttccggg tggcggtgtg     1680

ccgggcgcag gtgttcctgg tgtaggtgtg ccgggtgttg gtgtgccggg tgttggtgta     1740

ccaggtggcg gtgttccggg tgcaggcgtt ccgggtggcg gtgtgccggg cgtgggtgtt     1800

ccgggcgtgg gtgttccggg tggcggtgtg ccgggcgcag gtgttcctgg tgtaggtgtg     1860

ccgggtgttg gtgtgccggg tgttggtgta ccaggtggcg gtgttccggg tgcaggcgtt     1920

ccgggtggcg gtgtgccggg ctggccg                                         1947


<210>  131
<211>  787
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ELP1-120 FGF21 fusion PE9183

<400>  131

Met Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly 
1               5                   10                  15      


Val Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val 
            20                  25                  30          


Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro 
        35                  40                  45              


Gly Gly Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly 
    50                  55                  60                  


Gly Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro Gly Val 
65                  70                  75                  80  


Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly 
                85                  90                  95      


Val Pro Gly Gly Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val 
            100                 105                 110         


Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro 
        115                 120                 125             


Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly 
    130                 135                 140                 


Ala Gly Val Pro Gly Gly Gly Val Pro Gly Val Gly Val Pro Gly Val 
145                 150                 155                 160 


Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly 
                165                 170                 175     


Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val 
            180                 185                 190         


Pro Gly Ala Gly Val Pro Gly Gly Gly Val Pro Gly Val Gly Val Pro 
        195                 200                 205             


Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly 
    210                 215                 220                 


Val Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly 
225                 230                 235                 240 


Gly Val Pro Gly Ala Gly Val Pro Gly Gly Gly Val Pro Gly Val Gly 
                245                 250                 255     


Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val 
            260                 265                 270         


Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro 
        275                 280                 285             


Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Gly Gly Val Pro Gly 
    290                 295                 300                 


Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala 
305                 310                 315                 320 


Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Val Gly 
                325                 330                 335     


Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Gly Gly Val 
            340                 345                 350         


Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro 
        355                 360                 365             


Gly Ala Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly 
    370                 375                 380                 


Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Gly 
385                 390                 395                 400 


Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly 
                405                 410                 415     


Val Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val 
            420                 425                 430         


Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro 
        435                 440                 445             


Gly Gly Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly 
    450                 455                 460                 


Gly Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro Gly Val 
465                 470                 475                 480 


Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly 
                485                 490                 495     


Val Pro Gly Gly Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val 
            500                 505                 510         


Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro 
        515                 520                 525             


Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly 
    530                 535                 540                 


Ala Gly Val Pro Gly Gly Gly Val Pro Gly Val Gly Val Pro Gly Val 
545                 550                 555                 560 


Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly 
                565                 570                 575     


Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val 
            580                 585                 590         


Pro Gly Ala Gly Val Pro Gly Gly Gly Val Pro Gly Gly Pro His Pro 
        595                 600                 605             


Ile Pro Asp Ser Ser Pro Leu Leu Gln Phe Gly Gly Gln Val Arg Gln 
    610                 615                 620                 


Arg Tyr Leu Tyr Thr Asp Asp Ala Gln Gln Thr Glu Ala His Leu Glu 
625                 630                 635                 640 


Ile Arg Glu Asp Gly Thr Val Gly Gly Ala Ala Asp Gln Ser Pro Glu 
                645                 650                 655     


Ser Leu Leu Gln Leu Lys Ala Leu Lys Pro Gly Val Ile Gln Ile Leu 
            660                 665                 670         


Gly Val Lys Thr Ser Arg Phe Leu Cys Gln Arg Pro Asp Gly Ala Leu 
        675                 680                 685             


Tyr Gly Ser Leu His Phe Asp Pro Glu Ala Cys Ser Phe Arg Glu Leu 
    690                 695                 700                 


Leu Leu Glu Asp Gly Tyr Asn Val Tyr Gln Ser Glu Ala His Gly Leu 
705                 710                 715                 720 


Pro Leu His Leu Pro Gly Asn Lys Ser Pro His Arg Asp Pro Ala Pro 
                725                 730                 735     


Arg Gly Pro Ala Arg Phe Leu Pro Leu Pro Gly Leu Pro Pro Ala Pro 
            740                 745                 750         


Pro Glu Pro Pro Gly Ile Leu Ala Pro Gln Pro Pro Asp Val Gly Ser 
        755                 760                 765             


Ser Asp Pro Leu Ser Met Val Gly Pro Ser Gln Gly Arg Ser Pro Ser 
    770                 775                 780                 


Tyr Ala Ser 
785         


<210>  132
<211>  2361
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ELP1-120 FGF21 fusion PE9183

<400>  132
atggtaccgg gcgtgggtgt tccgggcgtg ggtgttccgg gtggcggtgt gccgggcgca       60

ggtgttcctg gtgtaggtgt gccgggtgtt ggtgtgccgg gtgttggtgt accaggtggc      120

ggtgttccgg gtgcaggcgt tccgggtggc ggtgtgccgg gcgtgggtgt tccgggcgtg      180

ggtgttccgg gtggcggtgt gccgggcgca ggtgttcctg gtgtaggtgt gccgggtgtt      240

ggtgtgccgg gtgttggtgt accaggtggc ggtgttccgg gtgcaggcgt tccgggtggc      300

ggtgtgccgg gcgtgggtgt tccgggcgtg ggtgttccgg gtggcggtgt gccgggcgca      360

ggtgttcctg gtgtaggtgt gccgggtgtt ggtgtgccgg gtgttggtgt accaggtggc      420

ggtgttccgg gtgcaggcgt tccgggtggc ggtgtgccgg gcgtgggtgt tccgggcgtg      480

ggtgttccgg gtggcggtgt gccgggcgca ggtgttcctg gtgtaggtgt gccgggtgtt      540

ggtgtgccgg gtgttggtgt accaggtggc ggtgttccgg gtgcaggcgt tccgggtggc      600

ggtgtgccgg gcgtgggtgt tccgggcgtg ggtgttccgg gtggcggtgt gccgggcgca      660

ggtgttcctg gtgtaggtgt gccgggtgtt ggtgtgccgg gtgttggtgt accaggtggc      720

ggtgttccgg gtgcaggcgt tccgggtggc ggtgtgccgg gcgtgggtgt tccgggcgtg      780

ggtgttccgg gtggcggtgt gccgggcgca ggtgttcctg gtgtaggtgt gccgggtgtt      840

ggtgtgccgg gtgttggtgt accaggtggc ggtgttccgg gtgcaggcgt tccgggtggc      900

ggtgtgccgg gcgtgggtgt tccgggcgtg ggtgttccgg gtggcggtgt gccgggcgca      960

ggtgttcctg gtgtaggtgt gccgggtgtt ggtgtgccgg gtgttggtgt accaggtggc     1020

ggtgttccgg gtgcaggcgt tccgggtggc ggtgtgccgg gcgtgggtgt tccgggcgtg     1080

ggtgttccgg gtggcggtgt gccgggcgca ggtgttcctg gtgtaggtgt gccgggtgtt     1140

ggtgtgccgg gtgttggtgt accaggtggc ggtgttccgg gtgcaggcgt tccgggtggc     1200

ggtgtgccgg gcgtgggtgt tccgggcgtg ggtgttccgg gtggcggtgt gccgggcgca     1260

ggtgttcctg gtgtaggtgt gccgggtgtt ggtgtgccgg gtgttggtgt accaggtggc     1320

ggtgttccgg gtgcaggcgt tccgggtggc ggtgtgccgg gcgtgggtgt tccgggcgtg     1380

ggtgttccgg gtggcggtgt gccgggcgca ggtgttcctg gtgtaggtgt gccgggtgtt     1440

ggtgtgccgg gtgttggtgt accaggtggc ggtgttccgg gtgcaggcgt tccgggtggc     1500

ggtgtgccgg gcgtgggtgt tccgggcgtg ggtgttccgg gtggcggtgt gccgggcgca     1560

ggtgttcctg gtgtaggtgt gccgggtgtt ggtgtgccgg gtgttggtgt accaggtggc     1620

ggtgttccgg gtgcaggcgt tccgggtggc ggtgtgccgg gcgtgggtgt tccgggcgtg     1680

ggtgttccgg gtggcggtgt gccgggcgca ggtgttcctg gtgtaggtgt gccgggtgtt     1740

ggtgtgccgg gtgttggtgt accaggtggc ggtgttccgg gtgcaggcgt tccgggtggc     1800

ggtgtgccgg gcgggccgca cccgatcccg gacagctctc cgctgctgca gtttggcggt     1860

caggtacgtc agcgttacct gtatactgac gacgcccagc agaccgaagc tcacctggag     1920

atccgcgaag acggtaccgt aggcggtgct gcagatcaat ctcctgaatc tctgctgcag     1980

ctgaaggcac tgaaaccggg cgttatccaa atcctgggtg ttaaaacttc tcgtttcctg     2040

tgccagcgcc cggatggtgc actgtacggt tctctgcatt tcgacccgga ggcctgctct     2100

ttccgtgaac tgctgctgga agatggttac aatgtatacc aatctgaggc acacggtctg     2160

ccgctgcacc tgcctggcaa caaatctccg catcgtgacc cggccccgcg cggtccagcc     2220

cgctttctgc cgctgccggg tctgccgccg gctccaccag aaccgcctgg tatcctggcg     2280

cctcagccac ctgatgttgg ctcctccgac ccgctgtcta tggtcggtcc gagccaaggc     2340

cgttccccaa gctacgccag t                                               2361


<210>  133
<211>  817
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLP1 ELP1-120 FGF21 dual fusion PE9193

<400>  133

His Gly Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Arg Gly Val 
            20                  25                  30          


Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro 
        35                  40                  45              


Gly Ala Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly 
    50                  55                  60                  


Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Gly 
65                  70                  75                  80  


Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly 
                85                  90                  95      


Val Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val 
            100                 105                 110         


Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro 
        115                 120                 125             


Gly Gly Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly 
    130                 135                 140                 


Gly Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro Gly Val 
145                 150                 155                 160 


Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly 
                165                 170                 175     


Val Pro Gly Gly Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val 
            180                 185                 190         


Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro 
        195                 200                 205             


Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly 
    210                 215                 220                 


Ala Gly Val Pro Gly Gly Gly Val Pro Gly Val Gly Val Pro Gly Val 
225                 230                 235                 240 


Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly 
                245                 250                 255     


Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val 
            260                 265                 270         


Pro Gly Ala Gly Val Pro Gly Gly Gly Val Pro Gly Val Gly Val Pro 
        275                 280                 285             


Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly 
    290                 295                 300                 


Val Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly 
305                 310                 315                 320 


Gly Val Pro Gly Ala Gly Val Pro Gly Gly Gly Val Pro Gly Val Gly 
                325                 330                 335     


Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val 
            340                 345                 350         


Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro 
        355                 360                 365             


Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Gly Gly Val Pro Gly 
    370                 375                 380                 


Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala 
385                 390                 395                 400 


Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Val Gly 
                405                 410                 415     


Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Gly Gly Val 
            420                 425                 430         


Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro 
        435                 440                 445             


Gly Ala Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly 
    450                 455                 460                 


Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Gly 
465                 470                 475                 480 


Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly 
                485                 490                 495     


Val Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val 
            500                 505                 510         


Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro 
        515                 520                 525             


Gly Gly Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly 
    530                 535                 540                 


Gly Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro Gly Val 
545                 550                 555                 560 


Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly 
                565                 570                 575     


Val Pro Gly Gly Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val 
            580                 585                 590         


Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro 
        595                 600                 605             


Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly 
    610                 615                 620                 


Ala Gly Val Pro Gly Gly Gly Val Pro Gly Gly Pro His Pro Ile Pro 
625                 630                 635                 640 


Asp Ser Ser Pro Leu Leu Gln Phe Gly Gly Gln Val Arg Gln Arg Tyr 
                645                 650                 655     


Leu Tyr Thr Asp Asp Ala Gln Gln Thr Glu Ala His Leu Glu Ile Arg 
            660                 665                 670         


Glu Asp Gly Thr Val Gly Gly Ala Ala Asp Gln Ser Pro Glu Ser Leu 
        675                 680                 685             


Leu Gln Leu Lys Ala Leu Lys Pro Gly Val Ile Gln Ile Leu Gly Val 
    690                 695                 700                 


Lys Thr Ser Arg Phe Leu Cys Gln Arg Pro Asp Gly Ala Leu Tyr Gly 
705                 710                 715                 720 


Ser Leu His Phe Asp Pro Glu Ala Cys Ser Phe Arg Glu Leu Leu Leu 
                725                 730                 735     


Glu Asp Gly Tyr Asn Val Tyr Gln Ser Glu Ala His Gly Leu Pro Leu 
            740                 745                 750         


His Leu Pro Gly Asn Lys Ser Pro His Arg Asp Pro Ala Pro Arg Gly 
        755                 760                 765             


Pro Ala Arg Phe Leu Pro Leu Pro Gly Leu Pro Pro Ala Pro Pro Glu 
    770                 775                 780                 


Pro Pro Gly Ile Leu Ala Pro Gln Pro Pro Asp Val Gly Ser Ser Asp 
785                 790                 795                 800 


Pro Leu Ser Met Val Gly Pro Ser Gln Gly Arg Ser Pro Ser Tyr Ala 
                805                 810                 815     


Ser 
    


<210>  134
<211>  2451
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  GLP1 ELP1-120 FGF21 dual fusion PE9193

<400>  134
catggcgaag gtacctttac aagcgatgtt agttcatatc tggagggcca ggcggcaaag       60

gaatttattg cgtggctggt gaaaggccgc ggcgtgccgg gcgtgggtgt tccgggcgtg      120

ggtgttccgg gtggcggtgt gccgggcgca ggtgttcctg gtgtaggtgt gccgggtgtt      180

ggtgtgccgg gtgttggtgt accaggtggc ggtgttccgg gtgcaggcgt tccgggtggc      240

ggtgtgccgg gcgtgggtgt tccgggcgtg ggtgttccgg gtggcggtgt gccgggcgca      300

ggtgttcctg gtgtaggtgt gccgggtgtt ggtgtgccgg gtgttggtgt accaggtggc      360

ggtgttccgg gtgcaggcgt tccgggtggc ggtgtgccgg gcgtgggtgt tccgggcgtg      420

ggtgttccgg gtggcggtgt gccgggcgca ggtgttcctg gtgtaggtgt gccgggtgtt      480

ggtgtgccgg gtgttggtgt accaggtggc ggtgttccgg gtgcaggcgt tccgggtggc      540

ggtgtgccgg gcgtgggtgt tccgggcgtg ggtgttccgg gtggcggtgt gccgggcgca      600

ggtgttcctg gtgtaggtgt gccgggtgtt ggtgtgccgg gtgttggtgt accaggtggc      660

ggtgttccgg gtgcaggcgt tccgggtggc ggtgtgccgg gcgtgggtgt tccgggcgtg      720

ggtgttccgg gtggcggtgt gccgggcgca ggtgttcctg gtgtaggtgt gccgggtgtt      780

ggtgtgccgg gtgttggtgt accaggtggc ggtgttccgg gtgcaggcgt tccgggtggc      840

ggtgtgccgg gcgtgggtgt tccgggcgtg ggtgttccgg gtggcggtgt gccgggcgca      900

ggtgttcctg gtgtaggtgt gccgggtgtt ggtgtgccgg gtgttggtgt accaggtggc      960

ggtgttccgg gtgcaggcgt tccgggtggc ggtgtgccgg gcgtgggtgt tccgggcgtg     1020

ggtgttccgg gtggcggtgt gccgggcgca ggtgttcctg gtgtaggtgt gccgggtgtt     1080

ggtgtgccgg gtgttggtgt accaggtggc ggtgttccgg gtgcaggcgt tccgggtggc     1140

ggtgtgccgg gcgtgggtgt tccgggcgtg ggtgttccgg gtggcggtgt gccgggcgca     1200

ggtgttcctg gtgtaggtgt gccgggtgtt ggtgtgccgg gtgttggtgt accaggtggc     1260

ggtgttccgg gtgcaggcgt tccgggtggc ggtgtgccgg gcgtgggtgt tccgggcgtg     1320

ggtgttccgg gtggcggtgt gccgggcgca ggtgttcctg gtgtaggtgt gccgggtgtt     1380

ggtgtgccgg gtgttggtgt accaggtggc ggtgttccgg gtgcaggcgt tccgggtggc     1440

ggtgtgccgg gcgtgggtgt tccgggcgtg ggtgttccgg gtggcggtgt gccgggcgca     1500

ggtgttcctg gtgtaggtgt gccgggtgtt ggtgtgccgg gtgttggtgt accaggtggc     1560

ggtgttccgg gtgcaggcgt tccgggtggc ggtgtgccgg gcgtgggtgt tccgggcgtg     1620

ggtgttccgg gtggcggtgt gccgggcgca ggtgttcctg gtgtaggtgt gccgggtgtt     1680

ggtgtgccgg gtgttggtgt accaggtggc ggtgttccgg gtgcaggcgt tccgggtggc     1740

ggtgtgccgg gcgtgggtgt tccgggcgtg ggtgttccgg gtggcggtgt gccgggcgca     1800

ggtgttcctg gtgtaggtgt gccgggtgtt ggtgtgccgg gtgttggtgt accaggtggc     1860

ggtgttccgg gtgcaggcgt tccgggtggc ggtgtgccgg gcgggccgca cccgatcccg     1920

gacagctctc cgctgctgca gtttggcggt caggtacgtc agcgttacct gtatactgac     1980

gacgcccagc agaccgaagc tcacctggag atccgcgaag acggtaccgt aggcggtgct     2040

gcagatcaat ctcctgaatc tctgctgcag ctgaaggcac tgaaaccggg cgttatccaa     2100

atcctgggtg ttaaaacttc tcgtttcctg tgccagcgcc cggatggtgc actgtacggt     2160

tctctgcatt tcgacccgga ggcctgctct ttccgtgaac tgctgctgga agatggttac     2220

aatgtatacc aatctgaggc acacggtctg ccgctgcacc tgcctggcaa caaatctccg     2280

catcgtgacc cggccccgcg cggtccagcc cgctttctgc cgctgccggg tctgccgccg     2340

gctccaccag aaccgcctgg tatcctggcg cctcagccac ctgatgttgg ctcctccgac     2400

ccgctgtcta tggtcggtcc gagccaaggc cgttccccaa gctacgccag t              2451
 

