                         SEQUENCE LISTING

<110>  Crucell Holland B.V.
       Bavarian Nordic A/S
       BUNNIK, Evelien M
       CUSTERS, Jerome H.H.V.
       SCHEPER, Gerrit C.
       KHAN, Selina
       KALLA, Markus
       WEIDNER, Katrin
 
<120>  Therapeutic HPV Vaccine Combinations

<130>  0269 US P00 PRO

<160>  33    

<170>  PatentIn version 3.5

<210>  1
<211>  328
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HPV16-E6E7SH designer polypeptide

<400>  1

Met His Gln Lys Arg Thr Ala Met Phe Gln Asp Pro Gln Glu Arg Pro 
1               5                   10                  15      


Arg Lys Leu Pro Gln Leu Cys Thr Glu Leu Gln Thr Thr Ile His Asp 
            20                  25                  30          


Ile Ile Leu Glu Cys Val Tyr Cys Lys Gln Gln Leu Glu Asp Glu Ile 
        35                  40                  45              


Asp Gly Pro Ala Gly Gln Ala Glu Pro Asp Arg Ala His Tyr Asn Ile 
    50                  55                  60                  


Val Thr Phe Cys Cys Lys Cys Asp Ser Thr Leu Arg Leu Cys Val Gln 
65                  70                  75                  80  


Ser Thr His Val Asp Ile Arg Thr Leu Glu Asp Leu Leu Met Gly Thr 
                85                  90                  95      


Leu Gly Ile Val Cys Pro Ile Cys Ser Gln Lys Pro Gly Thr Thr Leu 
            100                 105                 110         


Glu Gln Gln Tyr Asn Lys Pro Leu Cys Asp Leu Leu Ile Arg Cys Ile 
        115                 120                 125             


Asn Cys Gln Lys Pro Leu Cys Pro Glu Glu Lys Gln Arg His Leu Asp 
    130                 135                 140                 


Lys Lys Gln Arg Phe His Asn Ile Arg Gly Arg Trp Thr Gly Arg Cys 
145                 150                 155                 160 


Met Ser Cys Cys Arg Ser Ser Arg Thr Arg Arg Glu Thr Gln Met His 
                165                 170                 175     


Gly Asp Thr Pro Thr Leu His Glu Tyr Met Leu Asp Leu Gln Pro Glu 
            180                 185                 190         


Thr Thr Asp Leu Tyr Cys Tyr Glu Gln Leu Asn Asp Ser Ser Glu Glu 
        195                 200                 205             


Glu Asp Glu Ile Asp Gly Pro Ala Gly Gln Ala Glu Pro Asp Arg Ala 
    210                 215                 220                 


His Tyr Asn Ile Val Thr Phe Cys Cys Gln Leu Cys Thr Glu Leu Gln 
225                 230                 235                 240 


Thr Thr Ile His Asp Ile Ile Leu Glu Cys Val Tyr Cys Lys Gln Gln 
                245                 250                 255     


Leu Leu Arg Arg Glu Val Tyr Asp Phe Ala Phe Arg Asp Leu Cys Ile 
            260                 265                 270         


Val Tyr Arg Asp Gly Asn Pro Tyr Ala Val Cys Asp Lys Cys Leu Lys 
        275                 280                 285             


Phe Tyr Ser Lys Ile Ser Glu Tyr Arg His Tyr Cys Tyr Ser Leu Tyr 
    290                 295                 300                 


Gly Thr Thr Leu Glu Gln Gln Tyr Asn Lys Pro Leu Cys Asp Leu Leu 
305                 310                 315                 320 


Ile Arg Cys Ile Asn Cys Gln Lys 
                325             


<210>  2
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nt sequence encoding HPV16-E6E7SH designer polypeptide

<400>  2
atgcaccaga aacggaccgc catgttccag gacccccagg aacggcccag aaagctgccc       60

cagctgtgca ccgagctgca gaccaccatc cacgacatca tcctggaatg cgtgtactgc      120

aagcagcagc tggaagatga gatcgacggc cctgctggcc aggccgaacc cgacagagcc      180

cactacaata tcgtgacctt ctgctgcaag tgcgacagca ccctgcggct gtgcgtgcag      240

agcacccacg tggacatccg gaccctggaa gatctgctga tgggcaccct gggcatcgtg      300

tgccccatct gcagccagaa gcccggcacc accctggaac agcagtacaa caagcccctg      360

tgcgacctgc tgatccggtg catcaactgc cagaaacccc tgtgccccga ggaaaagcag      420

cggcacctgg acaagaagca gcggttccac aacatccggg gcagatggac aggcagatgc      480

atgagctgct gcagaagcag ccggaccaga cgggaaaccc agatgcacgg cgacaccccc      540

accctgcacg agtacatgct ggacctgcag cccgagacaa ccgacctgta ctgctacgag      600

cagctgaacg acagcagcga ggaagaggac gagattgacg gacccgctgg acaggccgag      660

cctgaccggg ctcactataa catcgtgaca ttttgctgtc agctctgtac tgaactccag      720

acaacaattc acgatattat tctcgaatgt gtgtattgta aacagcagct cctgcggaga      780

gaggtgtacg acttcgcctt ccgggacctc tgcatcgtgt atcgggacgg caacccctac      840

gccgtgtgcg acaagtgcct gaagttctac agcaagatca gcgagtaccg gcactactgc      900

tacagcctgt acggaacaac actcgaacag cagtataaca aaccactctg tgatctgctg      960

attcgctgta tcaattgtca gaagtgataa                                       990


<210>  3
<211>  693
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HPV16 E2E6E7SH designer polypeptide

<400>  3

Met Glu Thr Leu Cys Gln Arg Leu Asn Val Cys Gln Asp Lys Ile Leu 
1               5                   10                  15      


Thr His Tyr Glu Asn Asp Ser Thr Asp Leu Arg Asp His Ile Asp Tyr 
            20                  25                  30          


Trp Lys His Met Arg Leu Glu Cys Ala Ile Tyr Tyr Lys Ala Arg Glu 
        35                  40                  45              


Met Gly Phe Lys His Ile Asn His Gln Val Val Pro Thr Leu Ala Val 
    50                  55                  60                  


Ser Lys Asn Lys Ala Leu Gln Ala Ile Glu Leu Gln Leu Thr Leu Glu 
65                  70                  75                  80  


Thr Ile Tyr Asn Ser Gln Tyr Ser Asn Glu Lys Trp Thr Leu Gln Asp 
                85                  90                  95      


Val Ser Leu Glu Val Tyr Leu Thr Ala Pro Thr Gly Cys Ile Lys Lys 
            100                 105                 110         


His Gly Tyr Thr Val Glu Val Gln Phe Asp Gly Asp Ile Cys Asn Thr 
        115                 120                 125             


Met His Tyr Thr Asn Trp Thr His Ile Tyr Ile Cys Glu Glu Ala Ser 
    130                 135                 140                 


Val Thr Val Val Glu Gly Gln Val Asp Tyr Tyr Gly Leu Tyr Tyr Val 
145                 150                 155                 160 


His Glu Gly Ile Arg Thr Tyr Phe Val Gln Phe Lys Asp Asp Ala Glu 
                165                 170                 175     


Lys Tyr Ser Lys Asn Lys Val Trp Glu Val His Ala Gly Gly Gln Val 
            180                 185                 190         


Ile Leu Cys Pro Thr Ser Val Phe Ser Ser Asn Glu Val Ser Ser Pro 
        195                 200                 205             


Glu Ile Ile Arg Gln His Leu Ala Asn His Pro Ala Ala Thr His Thr 
    210                 215                 220                 


Lys Ala Val Ala Leu Gly Thr Glu Glu Thr Gln Thr Thr Ile Gln Arg 
225                 230                 235                 240 


Pro Arg Ser Glu Pro Asp Thr Gly Asn Pro Cys His Thr Thr Lys Leu 
                245                 250                 255     


Leu His Arg Asp Ser Val Asp Ser Ala Pro Ile Leu Thr Ala Phe Asn 
            260                 265                 270         


Ser Ser His Lys Gly Arg Ile Asn Cys Asn Ser Asn Thr Thr Pro Ile 
        275                 280                 285             


Val His Leu Lys Val Asp Ala Asn Thr Leu Met Arg Leu Arg Tyr Arg 
    290                 295                 300                 


Phe Lys Lys His Cys Thr Leu Tyr Thr Ala Val Ser Ser Thr Trp His 
305                 310                 315                 320 


Trp Thr Gly His Asn Val Lys His Lys Ser Ala Ile Val Thr Leu Thr 
                325                 330                 335     


Tyr Asp Ser Glu Trp Gln Arg Asp Gln Phe Leu Ser Gln Val Lys Ile 
            340                 345                 350         


Pro Lys Thr Ile Thr Val Ser Thr Gly Phe Met Ser Ile Met His Gln 
        355                 360                 365             


Lys Arg Thr Ala Met Phe Gln Asp Pro Gln Glu Arg Pro Arg Lys Leu 
    370                 375                 380                 


Pro Gln Leu Cys Thr Glu Leu Gln Thr Thr Ile His Asp Ile Ile Leu 
385                 390                 395                 400 


Glu Cys Val Tyr Cys Lys Gln Gln Leu Glu Asp Glu Ile Asp Gly Pro 
                405                 410                 415     


Ala Gly Gln Ala Glu Pro Asp Arg Ala His Tyr Asn Ile Val Thr Phe 
            420                 425                 430         


Cys Cys Lys Cys Asp Ser Thr Leu Arg Leu Cys Val Gln Ser Thr His 
        435                 440                 445             


Val Asp Ile Arg Thr Leu Glu Asp Leu Leu Met Gly Thr Leu Gly Ile 
    450                 455                 460                 


Val Cys Pro Ile Cys Ser Gln Lys Pro Gly Thr Thr Leu Glu Gln Gln 
465                 470                 475                 480 


Tyr Asn Lys Pro Leu Cys Asp Leu Leu Ile Arg Cys Ile Asn Cys Gln 
                485                 490                 495     


Lys Pro Leu Cys Pro Glu Glu Lys Gln Arg His Leu Asp Lys Lys Gln 
            500                 505                 510         


Arg Phe His Asn Ile Arg Gly Arg Trp Thr Gly Arg Cys Met Ser Cys 
        515                 520                 525             


Cys Arg Ser Ser Arg Thr Arg Arg Glu Thr Gln Met His Gly Asp Thr 
    530                 535                 540                 


Pro Thr Leu His Glu Tyr Met Leu Asp Leu Gln Pro Glu Thr Thr Asp 
545                 550                 555                 560 


Leu Tyr Cys Tyr Glu Gln Leu Asn Asp Ser Ser Glu Glu Glu Asp Glu 
                565                 570                 575     


Ile Asp Gly Pro Ala Gly Gln Ala Glu Pro Asp Arg Ala His Tyr Asn 
            580                 585                 590         


Ile Val Thr Phe Cys Cys Gln Leu Cys Thr Glu Leu Gln Thr Thr Ile 
        595                 600                 605             


His Asp Ile Ile Leu Glu Cys Val Tyr Cys Lys Gln Gln Leu Leu Arg 
    610                 615                 620                 


Arg Glu Val Tyr Asp Phe Ala Phe Arg Asp Leu Cys Ile Val Tyr Arg 
625                 630                 635                 640 


Asp Gly Asn Pro Tyr Ala Val Cys Asp Lys Cys Leu Lys Phe Tyr Ser 
                645                 650                 655     


Lys Ile Ser Glu Tyr Arg His Tyr Cys Tyr Ser Leu Tyr Gly Thr Thr 
            660                 665                 670         


Leu Glu Gln Gln Tyr Asn Lys Pro Leu Cys Asp Leu Leu Ile Arg Cys 
        675                 680                 685             


Ile Asn Cys Gln Lys 
    690             


<210>  4
<211>  2085
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nt sequence encoding HPV16 E2E6E7SH designer polypeptide

<400>  4
atggaaaccc tgtgccagcg gctgaacgtg tgccaggaca agatcctgac ccactacgag       60

aacgacagca ccgacctgcg ggaccacatc gactactgga agcacatgcg gctggaatgc      120

gccatctact acaaggccag agagatgggc ttcaagcaca tcaaccacca ggtggtgccc      180

accctggccg tgtccaagaa caaggccctg caggccatcg agctgcagct gaccctggaa      240

accatctaca acagccagta cagcaacgag aagtggaccc tgcaggacgt gtccctggaa      300

gtgtacctga ccgctcccac cggctgcatc aagaaacacg gctacaccgt ggaagtgcag      360

ttcgacggcg acatctgcaa caccatgcac tacaccaact ggacccacat ctacatctgc      420

gaagaggcca gcgtgaccgt ggtggaaggc caggtggact actacggcct gtactacgtg      480

cacgagggca tccggaccta cttcgtgcag ttcaaggacg acgccgagaa gtacagcaag      540

aacaaagtgt gggaggtgca cgctggcggc caggtcatcc tgtgccccac cagcgtgttc      600

agcagcaacg aggtgtccag ccccgagatc atccggcagc acctggccaa tcaccctgcc      660

gccacccaca caaaggccgt ggccctgggc accgaggaaa cccagaccac catccagcgg      720

cccagaagcg agcccgacac cggcaatccc tgccacacca ccaagctgct gcaccgggac      780

agcgtggaca gcgcccctat cctgaccgcc ttcaacagca gccacaaggg ccggatcaac      840

tgcaacagca acaccacccc catcgtgcac ctgaaggtgg acgccaacac cctgatgcgg      900

ctgcggtaca gattcaagaa gcactgcacc ctgtacaccg ccgtgtcctc cacctggcac      960

tggaccggcc acaacgtgaa gcacaagagc gccatcgtga ccctgaccta cgacagcgag     1020

tggcagcggg accagttcct gagccaggtc aaaatcccca agaccatcac cgtgtccacc     1080

ggcttcatga gcatcatgca ccagaaacgg accgccatgt tccaggaccc ccaggaacgg     1140

cccagaaagc tgccccagct gtgcaccgag ctgcagacca ccatccacga catcatcctg     1200

gaatgcgtgt actgcaagca gcagctggaa gatgagatcg acggccctgc tggccaggcc     1260

gaacccgaca gagcccacta caatatcgtg accttctgct gcaagtgcga cagcaccctg     1320

cggctgtgcg tgcagagcac ccacgtggac atccggaccc tggaagatct gctgatgggc     1380

accctgggca tcgtgtgccc catctgcagc cagaagcccg gcaccaccct ggaacagcag     1440

tacaacaagc ccctgtgcga cctgctgatc cggtgcatca actgccagaa acccctgtgc     1500

cccgaggaaa agcagcggca cctggacaag aagcagcggt tccacaacat ccggggcaga     1560

tggacaggca gatgcatgag ctgctgcaga agcagccgga ccagacggga aacccagatg     1620

cacggcgaca cccccaccct gcacgagtac atgctggacc tgcagcccga gacaaccgac     1680

ctgtactgct acgagcagct gaacgacagc agcgaggaag aggacgagat tgacggaccc     1740

gctggacagg ccgagcctga ccgggctcac tataacatcg tgacattttg ctgtcagctc     1800

tgtactgaac tccagacaac aattcacgat attattctcg aatgtgtgta ttgtaaacag     1860

cagctcctgc ggagagaggt gtacgacttc gccttccggg acctctgcat cgtgtatcgg     1920

gacggcaacc cctacgccgt gtgcgacaag tgcctgaagt tctacagcaa gatcagcgag     1980

taccggcact actgctacag cctgtacgga acaacactcg aacagcagta taacaaacca     2040

ctctgtgatc tgctgattcg ctgtatcaat tgtcagaagt gataa                     2085


<210>  5
<211>  693
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HPV16 E6E7E2SH designer polypeptide

<400>  5

Met His Gln Lys Arg Thr Ala Met Phe Gln Asp Pro Gln Glu Arg Pro 
1               5                   10                  15      


Arg Lys Leu Pro Gln Leu Cys Thr Glu Leu Gln Thr Thr Ile His Asp 
            20                  25                  30          


Ile Ile Leu Glu Cys Val Tyr Cys Lys Gln Gln Leu Glu Asp Glu Ile 
        35                  40                  45              


Asp Gly Pro Ala Gly Gln Ala Glu Pro Asp Arg Ala His Tyr Asn Ile 
    50                  55                  60                  


Val Thr Phe Cys Cys Lys Cys Asp Ser Thr Leu Arg Leu Cys Val Gln 
65                  70                  75                  80  


Ser Thr His Val Asp Ile Arg Thr Leu Glu Asp Leu Leu Met Gly Thr 
                85                  90                  95      


Leu Gly Ile Val Cys Pro Ile Cys Ser Gln Lys Pro Gly Thr Thr Leu 
            100                 105                 110         


Glu Gln Gln Tyr Asn Lys Pro Leu Cys Asp Leu Leu Ile Arg Cys Ile 
        115                 120                 125             


Asn Cys Gln Lys Pro Leu Cys Pro Glu Glu Lys Gln Arg His Leu Asp 
    130                 135                 140                 


Lys Lys Gln Arg Phe His Asn Ile Arg Gly Arg Trp Thr Gly Arg Cys 
145                 150                 155                 160 


Met Ser Cys Cys Arg Ser Ser Arg Thr Arg Arg Glu Thr Gln Met His 
                165                 170                 175     


Gly Asp Thr Pro Thr Leu His Glu Tyr Met Leu Asp Leu Gln Pro Glu 
            180                 185                 190         


Thr Thr Asp Leu Tyr Cys Tyr Glu Gln Leu Asn Asp Ser Ser Glu Glu 
        195                 200                 205             


Glu Asp Glu Ile Asp Gly Pro Ala Gly Gln Ala Glu Pro Asp Arg Ala 
    210                 215                 220                 


His Tyr Asn Ile Val Thr Phe Cys Cys Gln Leu Cys Thr Glu Leu Gln 
225                 230                 235                 240 


Thr Thr Ile His Asp Ile Ile Leu Glu Cys Val Tyr Cys Lys Gln Gln 
                245                 250                 255     


Leu Leu Arg Arg Glu Val Tyr Asp Phe Ala Phe Arg Asp Leu Cys Ile 
            260                 265                 270         


Val Tyr Arg Asp Gly Asn Pro Tyr Ala Val Cys Asp Lys Cys Leu Lys 
        275                 280                 285             


Phe Tyr Ser Lys Ile Ser Glu Tyr Arg His Tyr Cys Tyr Ser Leu Tyr 
    290                 295                 300                 


Gly Thr Thr Leu Glu Gln Gln Tyr Asn Lys Pro Leu Cys Asp Leu Leu 
305                 310                 315                 320 


Ile Arg Cys Ile Asn Cys Gln Lys Met Glu Thr Leu Cys Gln Arg Leu 
                325                 330                 335     


Asn Val Cys Gln Asp Lys Ile Leu Thr His Tyr Glu Asn Asp Ser Thr 
            340                 345                 350         


Asp Leu Arg Asp His Ile Asp Tyr Trp Lys His Met Arg Leu Glu Cys 
        355                 360                 365             


Ala Ile Tyr Tyr Lys Ala Arg Glu Met Gly Phe Lys His Ile Asn His 
    370                 375                 380                 


Gln Val Val Pro Thr Leu Ala Val Ser Lys Asn Lys Ala Leu Gln Ala 
385                 390                 395                 400 


Ile Glu Leu Gln Leu Thr Leu Glu Thr Ile Tyr Asn Ser Gln Tyr Ser 
                405                 410                 415     


Asn Glu Lys Trp Thr Leu Gln Asp Val Ser Leu Glu Val Tyr Leu Thr 
            420                 425                 430         


Ala Pro Thr Gly Cys Ile Lys Lys His Gly Tyr Thr Val Glu Val Gln 
        435                 440                 445             


Phe Asp Gly Asp Ile Cys Asn Thr Met His Tyr Thr Asn Trp Thr His 
    450                 455                 460                 


Ile Tyr Ile Cys Glu Glu Ala Ser Val Thr Val Val Glu Gly Gln Val 
465                 470                 475                 480 


Asp Tyr Tyr Gly Leu Tyr Tyr Val His Glu Gly Ile Arg Thr Tyr Phe 
                485                 490                 495     


Val Gln Phe Lys Asp Asp Ala Glu Lys Tyr Ser Lys Asn Lys Val Trp 
            500                 505                 510         


Glu Val His Ala Gly Gly Gln Val Ile Leu Cys Pro Thr Ser Val Phe 
        515                 520                 525             


Ser Ser Asn Glu Val Ser Ser Pro Glu Ile Ile Arg Gln His Leu Ala 
    530                 535                 540                 


Asn His Pro Ala Ala Thr His Thr Lys Ala Val Ala Leu Gly Thr Glu 
545                 550                 555                 560 


Glu Thr Gln Thr Thr Ile Gln Arg Pro Arg Ser Glu Pro Asp Thr Gly 
                565                 570                 575     


Asn Pro Cys His Thr Thr Lys Leu Leu His Arg Asp Ser Val Asp Ser 
            580                 585                 590         


Ala Pro Ile Leu Thr Ala Phe Asn Ser Ser His Lys Gly Arg Ile Asn 
        595                 600                 605             


Cys Asn Ser Asn Thr Thr Pro Ile Val His Leu Lys Val Asp Ala Asn 
    610                 615                 620                 


Thr Leu Met Arg Leu Arg Tyr Arg Phe Lys Lys His Cys Thr Leu Tyr 
625                 630                 635                 640 


Thr Ala Val Ser Ser Thr Trp His Trp Thr Gly His Asn Val Lys His 
                645                 650                 655     


Lys Ser Ala Ile Val Thr Leu Thr Tyr Asp Ser Glu Trp Gln Arg Asp 
            660                 665                 670         


Gln Phe Leu Ser Gln Val Lys Ile Pro Lys Thr Ile Thr Val Ser Thr 
        675                 680                 685             


Gly Phe Met Ser Ile 
    690             


<210>  6
<211>  2085
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nt sequence encoding HPV16 E6E7E2SH designer polypeptide

<400>  6
atgcaccaga aacggaccgc catgttccag gacccccagg aacggcccag aaagctgccc       60

cagctgtgca ccgagctgca gaccaccatc cacgacatca tcctggaatg cgtgtactgc      120

aagcagcagc tggaagatga gatcgacggc cctgctggcc aggccgaacc cgacagagcc      180

cactacaata tcgtgacctt ctgctgcaag tgcgacagca ccctgcggct gtgcgtgcag      240

agcacccacg tggacatccg gaccctggaa gatctgctga tgggcaccct gggcatcgtg      300

tgccccatct gcagccagaa gcccggcacc accctggaac agcagtacaa caagcccctg      360

tgcgacctgc tgatccggtg catcaactgc cagaaacccc tgtgccccga ggaaaagcag      420

cggcacctgg acaagaagca gcggttccac aacatccggg gcagatggac aggcagatgc      480

atgagctgct gcagaagcag ccggaccaga cgggaaaccc agatgcacgg cgacaccccc      540

accctgcacg agtacatgct ggacctgcag cccgagacaa ccgacctgta ctgctacgag      600

cagctgaacg acagcagcga ggaagaggac gagattgacg gacccgctgg acaggccgag      660

cctgaccggg ctcactataa catcgtgaca ttttgctgtc agctctgtac tgaactccag      720

acaacaattc acgatattat tctcgaatgt gtgtattgta aacagcagct cctgcggaga      780

gaggtgtacg acttcgcctt ccgggacctc tgcatcgtgt atcgggacgg caacccctac      840

gccgtgtgcg acaagtgcct gaagttctac agcaagatca gcgagtaccg gcactactgc      900

tacagcctgt acggaacaac actcgaacag cagtataaca aaccactctg tgatctgctg      960

attcgctgta tcaattgtca gaagatggaa accctgtgcc agcggctgaa cgtgtgccag     1020

gacaagatcc tgacccacta cgagaacgac agcaccgacc tgcgggacca catcgactac     1080

tggaagcaca tgcggctgga atgcgccatc tactacaagg ccagagagat gggcttcaag     1140

cacatcaacc accaggtggt gcccaccctg gccgtgtcca agaacaaggc cctgcaggcc     1200

atcgagctgc agctgaccct ggaaaccatc tacaacagcc agtacagcaa cgagaagtgg     1260

accctgcagg acgtgtccct ggaagtgtac ctgaccgctc ccaccggctg catcaagaaa     1320

cacggctaca ccgtggaagt gcagttcgac ggcgacatct gcaacaccat gcactacacc     1380

aactggaccc acatctacat ctgcgaagag gccagcgtga ccgtggtgga aggccaggtg     1440

gactactacg gcctgtacta cgtgcacgag ggcatccgga cctacttcgt gcagttcaag     1500

gacgacgccg agaagtacag caagaacaaa gtgtgggagg tgcacgctgg cggccaggtc     1560

atcctgtgcc ccaccagcgt gttcagcagc aacgaggtgt ccagccccga gatcatccgg     1620

cagcacctgg ccaatcaccc tgccgccacc cacacaaagg ccgtggccct gggcaccgag     1680

gaaacccaga ccaccatcca gcggcccaga agcgagcccg acaccggcaa tccctgccac     1740

accaccaagc tgctgcaccg ggacagcgtg gacagcgccc ctatcctgac cgccttcaac     1800

agcagccaca agggccggat caactgcaac agcaacacca cccccatcgt gcacctgaag     1860

gtggacgcca acaccctgat gcggctgcgg tacagattca agaagcactg caccctgtac     1920

accgccgtgt cctccacctg gcactggacc ggccacaacg tgaagcacaa gagcgccatc     1980

gtgaccctga cctacgacag cgagtggcag cgggaccagt tcctgagcca ggtcaaaatc     2040

cccaagacca tcaccgtgtc caccggcttc atgagcatct gataa                     2085


<210>  7
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgE leader peptide

<400>  7

Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser 
        


<210>  8
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nt sequence encoding IgE leader peptide

<400>  8
atggactgga cctggatcct gttcctggtg gctgccgcaa cccgggtgca cagc             54


<210>  9
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HAVT20 leader peptide

<400>  9

Met Ala Cys Pro Gly Phe Leu Trp Ala Leu Val Ile Ser Thr Cys Leu 
1               5                   10                  15      


Glu Phe Ser Met Ala 
            20      


<210>  10
<211>  63
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nt sequence encoding HAVT20 leader peptide

<400>  10
atggcctgcc ccggctttct gtgggccctg gtcatcagca cctgtctgga attcagcatg       60

gcc                                                                     63


<210>  11
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  2xTetO-containing sequence

<400>  11
gagctctccc tatcagtgat agagatctcc ctatcagtga tagagatcgt cgac             54


<210>  12
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  2xCuO-containing sequence

<400>  12
aacaaacaga caatctggtc tgtttgta                                          28


<210>  13
<211>  829
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CMV promoter

<400>  13
tcaatattgg ccattagcca tattattcat tggttatata gcataaatca atattggcta       60

ttggccattg catacgttgt atccatatca taatatgtac atttatattg gctcatgtcc      120

aacattaccg ccatgttgac attgattatt gactagttat taatagtaat caattacggg      180

gtcattagtt catagcccat atatggagtt ccgcgttaca taacttacgg taaatggccc      240

gcctggctga ccgcccaacg acccccgccc attgacgtca ataatgacgt atgttcccat      300

agtaacgcca atagggactt tccattgacg tcaatgggtg gagtatttac ggtaaactgc      360

ccacttggca gtacatcaag tgtatcatat gccaagtacg ccccctattg acgtcaatga      420

cggtaaatgg cccgcctggc attatgccca gtacatgacc ttatgggact ttcctacttg      480

gcagtacatc tacgtattag tcatcgctat taccatggtg atgcggtttt ggcagtacat      540

caatgggcgt ggatagcggt ttgactcacg gggatttcca agtctccacc ccattgacgt      600

caatgggagt ttgttttggc accaaaatca acgggacttt ccaaaatgtc gtaacaactc      660

cgccccattg acgcaaatgg gcggtaggcg tgtacggtgg gaggtctata taagcagagc      720

tcgtttagtg aaccgtcaga tcgcctggag acgccatcca cgctgttttg acctccatag      780

aagacaccgg gaccgatcca gcctccgcgg ccgggaacgg tgcattgga                  829


<210>  14
<211>  657
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nt sequence encoding TetR polypeptide

<400>  14
atgtctagat tagataaaag taaagtgatt aacagcgcat tagagctgct taatgaggtc       60

ggaatcgaag gtttaacaac ccgtaaactc gcccagaagc taggtgtaga gcagcctaca      120

ttgtattggc atgtaaaaaa taagcgggct ttgctcgacg ccttagccat tgagatgtta      180

gataggcacc atactcactt ttgcccttta gaaggggaaa gctggcaaga ttttttacgt      240

aataacgcta aaagttttag atgtgcttta ctaagtcatc gcgatggagc aaaagtacat      300

ttaggtacac ggcctacaga aaaacagtat gaaactctcg aaaatcaatt agccttttta      360

tgccaacaag gtttttcact agagaatgca ttatatgcac tcagcgctgt ggggcatttt      420

actttaggtt gcgtattgga agatcaagag catcaagtcg ctaaagaaga aagggaaaca      480

cctactactg atagtatgcc gccattatta cgacaagcta tcgaattatt tgatcaccaa      540

ggtgcagagc cagccttctt attcggcctt gaattgatca tatgcggatt agaaaaacaa      600

cttaaatgtg aaagtgggtc cgcgtacagc ggatcccggg aattcagatc ttattaa         657


<210>  15
<211>  218
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TetR polypeptide

<400>  15

Met Ser Arg Leu Asp Lys Ser Lys Val Ile Asn Ser Ala Leu Glu Leu 
1               5                   10                  15      


Leu Asn Glu Val Gly Ile Glu Gly Leu Thr Thr Arg Lys Leu Ala Gln 
            20                  25                  30          


Lys Leu Gly Val Glu Gln Pro Thr Leu Tyr Trp His Val Lys Asn Lys 
        35                  40                  45              


Arg Ala Leu Leu Asp Ala Leu Ala Ile Glu Met Leu Asp Arg His His 
    50                  55                  60                  


Thr His Phe Cys Pro Leu Glu Gly Glu Ser Trp Gln Asp Phe Leu Arg 
65                  70                  75                  80  


Asn Asn Ala Lys Ser Phe Arg Cys Ala Leu Leu Ser His Arg Asp Gly 
                85                  90                  95      


Ala Lys Val His Leu Gly Thr Arg Pro Thr Glu Lys Gln Tyr Glu Thr 
            100                 105                 110         


Leu Glu Asn Gln Leu Ala Phe Leu Cys Gln Gln Gly Phe Ser Leu Glu 
        115                 120                 125             


Asn Ala Leu Tyr Ala Leu Ser Ala Val Gly His Phe Thr Leu Gly Cys 
    130                 135                 140                 


Val Leu Glu Asp Gln Glu His Gln Val Ala Lys Glu Glu Arg Glu Thr 
145                 150                 155                 160 


Pro Thr Thr Asp Ser Met Pro Pro Leu Leu Arg Gln Ala Ile Glu Leu 
                165                 170                 175     


Phe Asp His Gln Gly Ala Glu Pro Ala Phe Leu Phe Gly Leu Glu Leu 
            180                 185                 190         


Ile Ile Cys Gly Leu Glu Lys Gln Leu Lys Cys Glu Ser Gly Ser Ala 
        195                 200                 205             


Tyr Ser Gly Ser Arg Glu Phe Arg Ser Tyr 
    210                 215             


<210>  16
<211>  612
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nt sequence encoding CymR polypeptide

<400>  16
atgtctccca aacgacggac tcaagcggaa agggcaatgg aaactcaggg taagctgatt       60

gccgcggctc tgggagtgct gcgagagaaa gggtatgccg ggtttcgcat agccgacgtt      120

cctggagctg caggcgtaag cagaggagcc caatctcatc actttccgac caagctggag      180

cttttgctgg ctaccttcga atggctgtac gagcagatca cggaaaggag tcgtgctagg      240

ctggccaagc tgaaacccga ggatgatgtc attcagcaga tgctggacga tgcagccgag      300

ttcttcctgg acgacgactt cagcatcagt ctcgacctca tcgtagccgc agatcgcgat      360

ccagctttgc gcgagggcat acagagaaca gtcgagcgga atcggtttgt ggtggaggac      420

atgtggcttg gtgttctggt gagcagaggc ctctcacggg atgatgccga ggacatcctg      480

tggctgatct ttaactccgt cagagggttg gcagtgaggt ccctttggca gaaggacaaa      540

gaacggtttg aacgtgtgcg aaactcaaca ctcgagattg ctagggaacg ctacgccaag      600

ttcaagagat ga                                                          612


<210>  17
<211>  203
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CymR polypeptide

<400>  17

Met Ser Pro Lys Arg Arg Thr Gln Ala Glu Arg Ala Met Glu Thr Gln 
1               5                   10                  15      


Gly Lys Leu Ile Ala Ala Ala Leu Gly Val Leu Arg Glu Lys Gly Tyr 
            20                  25                  30          


Ala Gly Phe Arg Ile Ala Asp Val Pro Gly Ala Ala Gly Val Ser Arg 
        35                  40                  45              


Gly Ala Gln Ser His His Phe Pro Thr Lys Leu Glu Leu Leu Leu Ala 
    50                  55                  60                  


Thr Phe Glu Trp Leu Tyr Glu Gln Ile Thr Glu Arg Ser Arg Ala Arg 
65                  70                  75                  80  


Leu Ala Lys Leu Lys Pro Glu Asp Asp Val Ile Gln Gln Met Leu Asp 
                85                  90                  95      


Asp Ala Ala Glu Phe Phe Leu Asp Asp Asp Phe Ser Ile Ser Leu Asp 
            100                 105                 110         


Leu Ile Val Ala Ala Asp Arg Asp Pro Ala Leu Arg Glu Gly Ile Gln 
        115                 120                 125             


Arg Thr Val Glu Arg Asn Arg Phe Val Val Glu Asp Met Trp Leu Gly 
    130                 135                 140                 


Val Leu Val Ser Arg Gly Leu Ser Arg Asp Asp Ala Glu Asp Ile Leu 
145                 150                 155                 160 


Trp Leu Ile Phe Asn Ser Val Arg Gly Leu Ala Val Arg Ser Leu Trp 
                165                 170                 175     


Gln Lys Asp Lys Glu Arg Phe Glu Arg Val Arg Asn Ser Thr Leu Glu 
            180                 185                 190         


Ile Ala Arg Glu Arg Tyr Ala Lys Phe Lys Arg 
        195                 200             


<210>  18
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HPV16 E6 aa41-65

<400>  18

Lys Gln Gln Leu Leu Arg Arg Glu Val Tyr Asp Phe Ala Phe Arg Asp 
1               5                   10                  15      


Leu Cys Ile Val Tyr Arg Asp Gly Asn 
            20                  25  


<210>  19
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HPV16 E7 aa43-77

<400>  19

Gly Gln Ala Glu Pro Asp Arg Ala His Tyr Asn Ile Val Thr Phe Cys 
1               5                   10                  15      


Cys Lys Cys Asp Ser Thr Leu Arg Leu Cys Val Gln Ser Thr His Val 
            20                  25                  30          


Asp Ile Arg 
        35  


<210>  20
<211>  331
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HPV18-E6E7SH designer polypeptide

<400>  20

Met Ala Arg Phe Glu Asp Pro Thr Arg Arg Pro Tyr Lys Leu Pro Asp 
1               5                   10                  15      


Leu Cys Thr Glu Leu Asn Thr Ser Leu Gln Asp Ile Glu Ile Thr Cys 
            20                  25                  30          


Val Tyr Cys Lys Thr Val Leu Asp Leu Leu Cys His Glu Gln Leu Ser 
        35                  40                  45              


Asp Ser Glu Glu Glu Asn Asp Glu Ile Asp Gly Val Asn His Gln His 
    50                  55                  60                  


Leu Pro Ala Arg Arg Ala Glu Pro Gln Arg His Thr Met Leu Cys Met 
65                  70                  75                  80  


Cys Cys Lys Cys Glu Ala Arg Ile Glu Leu Val Val Glu Ser Ser Ala 
                85                  90                  95      


Asp Asp Leu Arg Ala Phe Gln Gln Leu Phe Leu Asn Thr Leu Ser Phe 
            100                 105                 110         


Val Cys Pro Trp Cys Ala Ser Gln His Tyr Ser Asp Ser Val Tyr Gly 
        115                 120                 125             


Asp Thr Leu Glu Lys Leu Thr Asn Thr Gly Leu Tyr Asn Leu Leu Ile 
    130                 135                 140                 


Arg Cys Leu Arg Cys Gln Lys Pro Leu Asn Pro Ala Glu Lys Leu Arg 
145                 150                 155                 160 


His Leu Asn Glu Lys Arg Arg Phe His Asn Ile Ala Gly His Tyr Arg 
                165                 170                 175     


Gly Gln Cys His Ser Cys Cys Asn Arg Ala Arg Gln Glu Arg Leu Gln 
            180                 185                 190         


Arg Arg Arg Glu Thr Met His Gly Pro Lys Ala Thr Leu Gln Asp Ile 
        195                 200                 205             


Val Leu His Leu Glu Pro Gln Asn Glu Ile Pro Val Asp Leu Leu Cys 
    210                 215                 220                 


His Glu Gln Leu Ser Asp Ser Glu Glu Glu Asn Asp Glu Ile Asp Gly 
225                 230                 235                 240 


Val Asn Pro Asp Leu Cys Thr Glu Leu Asn Thr Ser Leu Gln Asp Ile 
                245                 250                 255     


Glu Ile Thr Cys Val Tyr Cys Lys Thr Val Leu Glu Leu Thr Glu Val 
            260                 265                 270         


Phe Glu Phe Ala Phe Lys Asp Leu Phe Val Val Tyr Arg Asp Ser Ile 
        275                 280                 285             


Pro His Ala Ala Cys His Lys Cys Ile Asp Phe Tyr Ser Arg Ile Arg 
    290                 295                 300                 


Glu Leu Arg His Tyr Ser Asp Ser Val Tyr Gly Asp Thr Leu Glu Lys 
305                 310                 315                 320 


Leu Thr Asn Thr Gly Leu Tyr Asn Leu Leu Ile 
                325                 330     


<210>  21
<211>  999
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nt sequence of HPV18-E6E7SH designer sequence

<400>  21
atggccagat tcgaggaccc caccagacgg ccctacaagc tgcccgacct gtgcaccgag       60

ctgaacacat ctctgcagga catcgagatc acatgcgtgt actgcaagac cgtgctggac      120

ctgctgtgcc acgagcagct gtccgactcc gaggaagaaa acgacgagat cgacggcgtg      180

aaccatcagc atctgcccgc cagacgggcc gagccccaga gacacaccat gctgtgcatg      240

tgctgcaagt gcgaggcccg gattgagctg gtggtggaaa gcagcgccga cgacctgcgg      300

gccttccagc agctctttct gaataccctg agcttcgtgt gcccttggtg cgccagccag      360

cactacagcg actccgtgta cggcgatacc ctggaaaagc tgaccaatac cggcctgtat      420

aacctgctga tccggtgcct gcggtgccag aagcccctga atcccgccga gaaactgaga      480

cacctgaacg agaagcggcg gttccacaat atcgccggcc actacagagg ccagtgccac      540

agctgctgca accgggccag acaggaacgg ctgcagcgga ggcgggaaac catgcacgga      600

cccaaggcca ccctccagga cattgtcctg cacctggaac cccagaacga gatccccgtc      660

gatctgctgt gtcatgaaca gctcagcgac agcgaagagg aaaatgacga aattgacggg      720

gtcaaccctg acctctgtac cgaactcaat accagtctcc aggatatcga aattacctgt      780

gtctactgta aaaccgtcct cgagctgacc gaggtgttcg agttcgcctt caaggacctg      840

tttgtggtgt acagagacag catcccccac gccgcctgcc acaagtgcat cgacttctac      900

agccggatca gagagctgcg gcactactcc gattctgtgt atggcgacac actcgagaag      960

ctcacaaaca caggactgta caatctgctc atctgataa                             999


<210>  22
<211>  696
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HPV18-E2E6E7SH designer sequence

<400>  22

Met Gln Thr Pro Lys Glu Thr Leu Ser Glu Arg Leu Ser Ala Leu Gln 
1               5                   10                  15      


Asp Lys Ile Ile Asp His Tyr Glu Asn Asp Ser Lys Asp Ile Asp Ser 
            20                  25                  30          


Gln Ile Gln Tyr Trp Gln Leu Ile Arg Trp Glu Asn Ala Ile Phe Phe 
        35                  40                  45              


Ala Ala Arg Glu His Gly Ile Gln Thr Leu Asn His Gln Val Val Pro 
    50                  55                  60                  


Ala Tyr Asn Ile Ser Lys Ser Lys Ala His Lys Ala Ile Glu Leu Gln 
65                  70                  75                  80  


Met Ala Leu Gln Gly Leu Ala Gln Ser Ala Tyr Lys Thr Glu Asp Trp 
                85                  90                  95      


Thr Leu Gln Asp Thr Cys Glu Glu Leu Trp Asn Thr Glu Pro Thr His 
            100                 105                 110         


Cys Phe Lys Lys Gly Gly Gln Thr Val Gln Val Tyr Phe Asp Gly Asn 
        115                 120                 125             


Lys Asp Asn Cys Met Thr Tyr Val Ala Trp Asp Ser Val Tyr Tyr Met 
    130                 135                 140                 


Thr Asp Ala Gly Thr Trp Asp Lys Thr Ala Thr Cys Val Ser His Arg 
145                 150                 155                 160 


Gly Leu Tyr Tyr Val Lys Glu Gly Tyr Asn Thr Phe Tyr Ile Glu Phe 
                165                 170                 175     


Lys Ser Glu Cys Glu Lys Tyr Gly Asn Thr Gly Thr Trp Glu Val His 
            180                 185                 190         


Phe Gly Asn Asn Val Ile Asp Cys Asn Asp Ser Met Cys Ser Thr Ser 
        195                 200                 205             


Asp Asp Thr Val Ser Ala Thr Gln Leu Val Lys Gln Leu Gln His Thr 
    210                 215                 220                 


Pro Ser Pro Tyr Ser Ser Thr Val Ser Val Gly Thr Ala Lys Thr Tyr 
225                 230                 235                 240 


Gly Gln Thr Ser Ala Ala Thr Arg Pro Gly His Cys Gly Leu Ala Glu 
                245                 250                 255     


Lys Gln His Cys Gly Pro Val Asn Pro Leu Leu Gly Ala Ala Thr Pro 
            260                 265                 270         


Thr Gly Asn Asn Lys Arg Arg Lys Leu Cys Ser Gly Asn Thr Thr Pro 
        275                 280                 285             


Ile Ile His Leu Lys Val Asp Arg Asn Ser Leu Met Arg Leu Arg Tyr 
    290                 295                 300                 


Arg Leu Arg Lys His Ser Asp His Tyr Arg Asp Ile Ser Ser Thr Trp 
305                 310                 315                 320 


His Trp Thr Gly Ala Gly Asn Glu Lys Thr Gly Ile Leu Thr Val Thr 
                325                 330                 335     


Tyr His Ser Glu Thr Gln Arg Thr Lys Phe Leu Asn Thr Val Ala Ile 
            340                 345                 350         


Pro Asp Ser Val Gln Ile Leu Val Gly Tyr Met Thr Met Met Ala Arg 
        355                 360                 365             


Phe Glu Asp Pro Thr Arg Arg Pro Tyr Lys Leu Pro Asp Leu Cys Thr 
    370                 375                 380                 


Glu Leu Asn Thr Ser Leu Gln Asp Ile Glu Ile Thr Cys Val Tyr Cys 
385                 390                 395                 400 


Lys Thr Val Leu Asp Leu Leu Cys His Glu Gln Leu Ser Asp Ser Glu 
                405                 410                 415     


Glu Glu Asn Asp Glu Ile Asp Gly Val Asn His Gln His Leu Pro Ala 
            420                 425                 430         


Arg Arg Ala Glu Pro Gln Arg His Thr Met Leu Cys Met Cys Cys Lys 
        435                 440                 445             


Cys Glu Ala Arg Ile Glu Leu Val Val Glu Ser Ser Ala Asp Asp Leu 
    450                 455                 460                 


Arg Ala Phe Gln Gln Leu Phe Leu Asn Thr Leu Ser Phe Val Cys Pro 
465                 470                 475                 480 


Trp Cys Ala Ser Gln His Tyr Ser Asp Ser Val Tyr Gly Asp Thr Leu 
                485                 490                 495     


Glu Lys Leu Thr Asn Thr Gly Leu Tyr Asn Leu Leu Ile Arg Cys Leu 
            500                 505                 510         


Arg Cys Gln Lys Pro Leu Asn Pro Ala Glu Lys Leu Arg His Leu Asn 
        515                 520                 525             


Glu Lys Arg Arg Phe His Asn Ile Ala Gly His Tyr Arg Gly Gln Cys 
    530                 535                 540                 


His Ser Cys Cys Asn Arg Ala Arg Gln Glu Arg Leu Gln Arg Arg Arg 
545                 550                 555                 560 


Glu Thr Met His Gly Pro Lys Ala Thr Leu Gln Asp Ile Val Leu His 
                565                 570                 575     


Leu Glu Pro Gln Asn Glu Ile Pro Val Asp Leu Leu Cys His Glu Gln 
            580                 585                 590         


Leu Ser Asp Ser Glu Glu Glu Asn Asp Glu Ile Asp Gly Val Asn Pro 
        595                 600                 605             


Asp Leu Cys Thr Glu Leu Asn Thr Ser Leu Gln Asp Ile Glu Ile Thr 
    610                 615                 620                 


Cys Val Tyr Cys Lys Thr Val Leu Glu Leu Thr Glu Val Phe Glu Phe 
625                 630                 635                 640 


Ala Phe Lys Asp Leu Phe Val Val Tyr Arg Asp Ser Ile Pro His Ala 
                645                 650                 655     


Ala Cys His Lys Cys Ile Asp Phe Tyr Ser Arg Ile Arg Glu Leu Arg 
            660                 665                 670         


His Tyr Ser Asp Ser Val Tyr Gly Asp Thr Leu Glu Lys Leu Thr Asn 
        675                 680                 685             


Thr Gly Leu Tyr Asn Leu Leu Ile 
    690                 695     


<210>  23
<211>  2094
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nt sequence encoding HPV18-E2E6E7SH designer sequence

<400>  23
atgcagaccc ccaaagagac actgagcgag cggctgagcg ccctgcagga caagatcatc       60

gaccactacg agaacgacag caaggacatc gacagccaga tccagtactg gcagctgatc      120

agatgggaga acgccatctt cttcgccgcc agagagcacg gcatccagac cctgaaccac      180

caggtggtgc ccgcctacaa catcagcaag agcaaggccc acaaggctat cgagctgcag      240

atggccctgc agggactggc ccagagcgcc tacaagaccg aggactggac cctgcaggat      300

acctgcgagg aactgtggaa caccgagccc acccactgct tcaagaaagg cggccagacc      360

gtgcaggtgt acttcgacgg caacaaggac aactgcatga cctacgtggc ctgggacagc      420

gtgtactaca tgaccgacgc cggcacctgg gacaagaccg ccacctgtgt gtcccaccgg      480

ggcctgtact acgtgaaaga gggctacaac accttctaca tcgagttcaa gagcgagtgc      540

gagaagtacg gcaacaccgg cacatgggag gtgcacttcg gcaacaacgt gatcgactgc      600

aacgacagca tgtgcagcac cagcgacgac accgtgtccg ccacccagct ggtgaaacag      660

ctgcagcaca cccccagccc ctacagcagc accgtgtctg tgggcaccgc caagacctac      720

ggccagacca gcgccgccac cagacctgga cactgtggcc tggccgagaa gcagcactgc      780

ggccctgtga accctctgct gggagccgcc acccccaccg gcaacaacaa gcggagaaag      840

ctgtgcagcg gcaacaccac ccccatcatc cacctgaagg tggaccggaa cagcctgatg      900

cggctgcggt acagactgcg gaagcacagc gaccactacc gggacatcag cagcacctgg      960

cactggaccg gcgctggcaa cgagaaaacc ggcatcctga ccgtgaccta ccacagcgaa     1020

acccagcgga ccaagttcct gaacaccgtg gccatccccg acagcgtgca gatcctggtg     1080

ggatatatga ccatgatggc cagattcgag gaccccacca gacggcccta caagctgccc     1140

gacctgtgca ccgagctgaa cacatctctg caggacatcg agatcacatg cgtgtactgc     1200

aagaccgtgc tggacctgct gtgccacgag cagctgtccg actccgagga agaaaacgac     1260

gagatcgacg gcgtgaacca tcagcatctg cccgccagac gggccgagcc ccagagacac     1320

accatgctgt gcatgtgctg caagtgcgag gcccggattg agctggtggt ggaaagcagc     1380

gccgacgacc tgcgggcctt ccagcagctc tttctgaata ccctgagctt cgtgtgccct     1440

tggtgcgcca gccagcacta cagcgactcc gtgtacggcg ataccctgga aaagctgacc     1500

aataccggcc tgtataacct gctgatccgg tgcctgcggt gccagaagcc cctgaatccc     1560

gccgagaaac tgagacacct gaacgagaag cggcggttcc acaatatcgc cggccactac     1620

agaggccagt gccacagctg ctgcaaccgg gccagacagg aacggctgca gcggaggcgg     1680

gaaaccatgc acggacccaa ggccaccctc caggacattg tcctgcacct ggaaccccag     1740

aacgagatcc ccgtcgatct gctgtgtcat gaacagctca gcgacagcga agaggaaaat     1800

gacgaaattg acggggtcaa ccctgacctc tgtaccgaac tcaataccag tctccaggat     1860

atcgaaatta cctgtgtcta ctgtaaaacc gtcctcgagc tgaccgaggt gttcgagttc     1920

gccttcaagg acctgtttgt ggtgtacaga gacagcatcc cccacgccgc ctgccacaag     1980

tgcatcgact tctacagccg gatcagagag ctgcggcact actccgattc tgtgtatggc     2040

gacacactcg agaagctcac aaacacagga ctgtacaatc tgctcatctg ataa           2094


<210>  24
<211>  2085
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nt sequence encoding HPV16 E2E6E7SH designer polypeptide

<400>  24
atggaaacgc tctgccagag actcaatgtc tgccaggata agattctcac gcattatgag       60

aacgattcca cggacctgcg cgatcacatt gattattgga aacacatgcg ccttgagtgt      120

gctatctatt ataaggctcg cgaaatgggt ttcaaacata tcaatcatca ggtcgtccct      180

accctcgccg tcagcaaaaa caaagctctg caggctattg aactccagct caccctcgag      240

acaatctaca attcccagta ctccaatgag aaatggacgc tccaggatgt gtctctcgag      300

gtctacctga cagctcctac aggatgtatt aagaaacacg ggtacacggt ggaagtccag      360

tttgatggcg atatatgtaa taccatgcat tatacgaatt ggacgcatat ctatatttgt      420

gaagaggcct ctgtgacagt ggtcgaggga caggtcgact attatgggct gtattatgtg      480

cacgaaggga tcagaacata ctttgtccag tttaaggatg atgctgagaa gtattctaag      540

aacaaagttt gggaagtcca tgccggtgga caagtgattc tgtgtcctac ctccgtgttc      600

agctctaatg aggtgtcctc tccagagatc attagacagc atctggccaa ccatcctgct      660

gctacacata ccaaggctgt ggctctggga acagaagaga cacagacaac aatccagagg      720

cctcggagcg agcctgatac aggcaaccct tgtcacacaa caaaactgct gcacagagac      780

tccgtggact ccgctcctat tctgacagcc tttaactcct cccacaaagg gagaatcaat      840

tgcaattcca ataccacgcc gatcgtccac ctcaaagtgg atgctaatac tctcatgcgg      900

ctccgctacc gcttcaagaa acactgtaca ctgtatacag ctgtgtccag cacatggcat      960

tggacgggac acaatgtgaa acataagtcc gccatcgtca cgctcacata cgattccgag     1020

tggcagagag atcagtttct gtcccaagtc aagattccga aaacgatcac cgtcagcacc     1080

ggctttatgt ctattatgca ccagaaacgc acggctatgt ttcaagatcc acaagagcga     1140

cccagaaaac tgcctcagct gtgtacagaa ctgcaaacaa ccatccatga catcattctt     1200

gagtgtgttt attgcaagca acagctcgag gacgaaatcg atggacctgc tggacaggcc     1260

gaacccgata gggctcacta caacatcgtc acgttttgtt gcaagtgtga ctccaccctg     1320

agactgtgtg tgcagtctac ccatgtggat atcagaaccc tcgaggacct gctcatggga     1380

acactcggta ttgtgtgtcc tatctgctcc cagaagcctg gaacaactct cgagcaacag     1440

tacaacaagc cgctctgtga tctcctgatc agatgcatta actgtcagaa gcctctctgc     1500

cctgaagaga agcagagaca cctcgataag aaacagcgct ttcacaatat cagaggccgg     1560

tggaccggca gatgcatgtc ctgctgtcgg agcagcagaa ccagacgcga gacacagatg     1620

catggcgata cacctacact ccatgagtat atgctcgatc tccagcctga aaccaccgat     1680

ctctactgtt atgagcagct caatgacagc agcgaagagg aagatgagat tgacggacca     1740

gctgggcaag ccgagccaga tcgcgcacat tacaatatcg ttaccttttg ttgtcagctc     1800

tgcacagagt tgcaaacgac gattcacgac attatattgg agtgcgtgta ctgtaaacaa     1860

cagctgctgc ggagagaagt ctacgatttc gcctttagag atctctgcat cgtctacaga     1920

gatgggaatc cctatgccgt ctgtgataag tgtctcaagt tttactccaa gatctccgag     1980

tatcgccatt actgttactc cctgtacggg acaaccttgg agcagcagta taacaagcca     2040

ttgtgtgatc tgctcattcg gtgtattaac tgccaaaagt gatga                     2085


<210>  25
<211>  2094
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleotide sequence encoding HPV16 E2E6E7SH designer polypeptide

<400>  25
atgcagacgc cgaaagaaac cctgtccgag agactgagcg ctctccaaga taagattatt       60

gatcactatg agaatgactc caaggacatt gattcccaga ttcagtattg gcaacttatt      120

cgctgggaaa atgccatctt ctttgccgct cgggaacacg ggattcagac actgaatcat      180

caagtggtcc cagcctacaa tatctccaag tccaaagccc acaaagctat cgaactccaa      240

atggctctcc agggactggc tcagtccgct tataagacag aagattggac actccaggac      300

acgtgtgaag aactctggaa taccgaaccg acgcactgtt ttaagaaggg tggacagaca      360

gttcaagtct actttgatgg gaacaaagat aattgcatga catatgtcgc ttgggattcc      420

gtctactata tgacagatgc tgggacgtgg gataagacag ccacatgcgt cagccacaga      480

gggctgtact atgtcaaaga agggtataat acgttctata tcgagtttaa gtctgaatgc      540

gagaaatatg ggaatacggg aacctgggaa gtgcattttg ggaacaatgt catcgattgc      600

aatgactcca tgtgctccac ctccgatgac acagtcagcg ccacacagct cgtgaaacag      660

ctccagcata caccatctcc ctactcctcc actgtgtccg tgggaacagc caaaacatat      720

ggacagacct ccgctgccac acggcctggc cattgcggac tggccgagaa acagcattgt      780

ggaccagtca accctctgct gggagctgct actccaacag ggaacaacaa gaggcggaaa      840

ctgtgttccg gcaatacgac acctatcatt cacctcaagg tcgacagaaa ctccctgatg      900

agactgagat accggctgag aaagcactcc gatcactaca gagatatcag ctctacttgg      960

cattggacag gtgctggaaa cgaaaagaca gggatcctga cagtgacgta tcactccgag     1020

actcagcgca ccaaatttct caatactgtg gccattcccg attccgtgca gattcttgtc     1080

ggatatatga cgatgatggc tcgctttgag gatcctacaa gaaggcctta taagctccct     1140

gatctctgca ctgagcttaa caccagcctg caagacattg aaatcacttg tgtctattgc     1200

aaaacggtcc tggacctcct ctgtcacgaa caactgtctg atagtgaaga ggagaatgat     1260

gagatcgatg gtgtcaacca ccagcacctc cctgctcgga gagccgagcc tcagcggcat     1320

acaatgctct gtatgtgttg taaatgcgag gccagaatcg aactcgtggt cgagtcctcc     1380

gccgacgatc tgagagcttt tcagcaactg tttctcaaca ccctgtcctt tgtctgtcct     1440

tggtgtgcct cccagcatta ctccgattct gtgtatggcg acactctcga gaagctcact     1500

aacacgggac tgtataatct gctcatccgc tgtctgagat gccagaaacc tctgaatcct     1560

gccgagaaac tgcgccacct caatgagaag agaagattcc acaacattgc cggacattat     1620

cgaggccagt gtcactcctg ctgtaacaga gctcggcaag agagactgca gagaaggcgc     1680

gagacaatgc acggacctaa agccaccctc caggacattg tgctgcatct cgagcctcag     1740

aatgagattc ctgtcgactt gctctgccat gagcaactgt ccgattctga ggaagaaaat     1800

gacgaaatag atggcgtgaa ccctgacttg tgcactgaac tcaatacttc cctgcaagat     1860

atagagataa cgtgcgttta ctgtaagacg gtcctcgaac tcaccgaagt ctttgagttt     1920

gcctttaagg atctctttgt cgtctaccgc gactccatcc ctcacgctgc ttgtcacaaa     1980

tgtatcgatt tttactctcg catcagagaa ctgcggcact actctgactc agtgtatggc     2040

gatactttgg agaagcttac caatacgggc ctctataact tgctgatctg atga           2094


<210>  26
<211>  124
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PrMVA Promoter

<400>  26
taaaaataga aactataatc atataatagt gtaggttggt agtattgctc ttgtgactag       60

agactttagt taaggtactg taaaaataga aactataatc atataatagt gtaggttggt      120

agta                                                                   124


<210>  27
<211>  227
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PrHyb Promoter

<400>  27
gttttgaaaa tttttttata ataaatatcc ggtaaaaatt gaaaaactat tctaatttat       60

tgcacggtcc ggtaaaaatt gaaaaactat tctaatttat tgcacggtcc ggtaaaaatt      120

gaaaaactat tctaatttat tgcacggtcc ggtaaaaatt gaaaaactat tctaatttat      180

tgcacggtcc ggtaaaaatt gaaaaactat tctaatttat tgcacgg                    227


<210>  28
<211>  365
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HPV 16 E2 fragment

<400>  28

Met Glu Thr Leu Cys Gln Arg Leu Asn Val Cys Gln Asp Lys Ile Leu 
1               5                   10                  15      


Thr His Tyr Glu Asn Asp Ser Thr Asp Leu Arg Asp His Ile Asp Tyr 
            20                  25                  30          


Trp Lys His Met Arg Leu Glu Cys Ala Ile Tyr Tyr Lys Ala Arg Glu 
        35                  40                  45              


Met Gly Phe Lys His Ile Asn His Gln Val Val Pro Thr Leu Ala Val 
    50                  55                  60                  


Ser Lys Asn Lys Ala Leu Gln Ala Ile Glu Leu Gln Leu Thr Leu Glu 
65                  70                  75                  80  


Thr Ile Tyr Asn Ser Gln Tyr Ser Asn Glu Lys Trp Thr Leu Gln Asp 
                85                  90                  95      


Val Ser Leu Glu Val Tyr Leu Thr Ala Pro Thr Gly Cys Ile Lys Lys 
            100                 105                 110         


His Gly Tyr Thr Val Glu Val Gln Phe Asp Gly Asp Ile Cys Asn Thr 
        115                 120                 125             


Met His Tyr Thr Asn Trp Thr His Ile Tyr Ile Cys Glu Glu Ala Ser 
    130                 135                 140                 


Val Thr Val Val Glu Gly Gln Val Asp Tyr Tyr Gly Leu Tyr Tyr Val 
145                 150                 155                 160 


His Glu Gly Ile Arg Thr Tyr Phe Val Gln Phe Lys Asp Asp Ala Glu 
                165                 170                 175     


Lys Tyr Ser Lys Asn Lys Val Trp Glu Val His Ala Gly Gly Gln Val 
            180                 185                 190         


Ile Leu Cys Pro Thr Ser Val Phe Ser Ser Asn Glu Val Ser Ser Pro 
        195                 200                 205             


Glu Ile Ile Arg Gln His Leu Ala Asn His Pro Ala Ala Thr His Thr 
    210                 215                 220                 


Lys Ala Val Ala Leu Gly Thr Glu Glu Thr Gln Thr Thr Ile Gln Arg 
225                 230                 235                 240 


Pro Arg Ser Glu Pro Asp Thr Gly Asn Pro Cys His Thr Thr Lys Leu 
                245                 250                 255     


Leu His Arg Asp Ser Val Asp Ser Ala Pro Ile Leu Thr Ala Phe Asn 
            260                 265                 270         


Ser Ser His Lys Gly Arg Ile Asn Cys Asn Ser Asn Thr Thr Pro Ile 
        275                 280                 285             


Val His Leu Lys Val Asp Ala Asn Thr Leu Met Arg Leu Arg Tyr Arg 
    290                 295                 300                 


Phe Lys Lys His Cys Thr Leu Tyr Thr Ala Val Ser Ser Thr Trp His 
305                 310                 315                 320 


Trp Thr Gly His Asn Val Lys His Lys Ser Ala Ile Val Thr Leu Thr 
                325                 330                 335     


Tyr Asp Ser Glu Trp Gln Arg Asp Gln Phe Leu Ser Gln Val Lys Ile 
            340                 345                 350         


Pro Lys Thr Ile Thr Val Ser Thr Gly Phe Met Ser Ile 
        355                 360                 365 


<210>  29
<211>  1095
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nt sequence encoding HPV 16 E2 fragment 

<400>  29
atggaaaccc tgtgccagcg gctgaacgtg tgccaggaca agatcctgac ccactacgag       60

aacgacagca ccgacctgcg ggaccacatc gactactgga agcacatgcg gctggaatgc      120

gccatctact acaaggccag agagatgggc ttcaagcaca tcaaccacca ggtggtgccc      180

accctggccg tgtccaagaa caaggccctg caggccatcg agctgcagct gaccctggaa      240

accatctaca acagccagta cagcaacgag aagtggaccc tgcaggacgt gtccctggaa      300

gtgtacctga ccgctcccac cggctgcatc aagaaacacg gctacaccgt ggaagtgcag      360

ttcgacggcg acatctgcaa caccatgcac tacaccaact ggacccacat ctacatctgc      420

gaagaggcca gcgtgaccgt ggtggaaggc caggtggact actacggcct gtactacgtg      480

cacgagggca tccggaccta cttcgtgcag ttcaaggacg acgccgagaa gtacagcaag      540

aacaaagtgt gggaggtgca cgctggcggc caggtcatcc tgtgccccac cagcgtgttc      600

agcagcaacg aggtgtccag ccccgagatc atccggcagc acctggccaa tcaccctgcc      660

gccacccaca caaaggccgt ggccctgggc accgaggaaa cccagaccac catccagcgg      720

cccagaagcg agcccgacac cggcaatccc tgccacacca ccaagctgct gcaccgggac      780

agcgtggaca gcgcccctat cctgaccgcc ttcaacagca gccacaaggg ccggatcaac      840

tgcaacagca acaccacccc catcgtgcac ctgaaggtgg acgccaacac cctgatgcgg      900

ctgcggtaca gattcaagaa gcactgcacc ctgtacaccg ccgtgtcctc cacctggcac      960

tggaccggcc acaacgtgaa gcacaagagc gccatcgtga ccctgaccta cgacagcgag     1020

tggcagcggg accagttcct gagccaggtc aaaatcccca agaccatcac cgtgtccacc     1080

ggcttcatga gcatc                                                      1095


<210>  30
<211>  1095
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleotide sequence encoding HPV 16 E2 fragment 

<400>  30
atggaaacgc tctgccagag actcaatgtc tgccaggata agattctcac gcattatgag       60

aacgattcca cggacctgcg cgatcacatt gattattgga aacacatgcg ccttgagtgt      120

gctatctatt ataaggctcg cgaaatgggt ttcaaacata tcaatcatca ggtcgtccct      180

accctcgccg tcagcaaaaa caaagctctg caggctattg aactccagct caccctcgag      240

acaatctaca attcccagta ctccaatgag aaatggacgc tccaggatgt gtctctcgag      300

gtctacctga cagctcctac aggatgtatt aagaaacacg ggtacacggt ggaagtccag      360

tttgatggcg atatatgtaa taccatgcat tatacgaatt ggacgcatat ctatatttgt      420

gaagaggcct ctgtgacagt ggtcgaggga caggtcgact attatgggct gtattatgtg      480

cacgaaggga tcagaacata ctttgtccag tttaaggatg atgctgagaa gtattctaag      540

aacaaagttt gggaagtcca tgccggtgga caagtgattc tgtgtcctac ctccgtgttc      600

agctctaatg aggtgtcctc tccagagatc attagacagc atctggccaa ccatcctgct      660

gctacacata ccaaggctgt ggctctggga acagaagaga cacagacaac aatccagagg      720

cctcggagcg agcctgatac aggcaaccct tgtcacacaa caaaactgct gcacagagac      780

tccgtggact ccgctcctat tctgacagcc tttaactcct cccacaaagg gagaatcaat      840

tgcaattcca ataccacgcc gatcgtccac ctcaaagtgg atgctaatac tctcatgcgg      900

ctccgctacc gcttcaagaa acactgtaca ctgtatacag ctgtgtccag cacatggcat      960

tggacgggac acaatgtgaa acataagtcc gccatcgtca cgctcacata cgattccgag     1020

tggcagagag atcagtttct gtcccaagtc aagattccga aaacgatcac cgtcagcacc     1080

ggctttatgt ctatt                                                      1095


<210>  31
<211>  365
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HPV 18 E2 fragment

<400>  31

Met Gln Thr Pro Lys Glu Thr Leu Ser Glu Arg Leu Ser Ala Leu Gln 
1               5                   10                  15      


Asp Lys Ile Ile Asp His Tyr Glu Asn Asp Ser Lys Asp Ile Asp Ser 
            20                  25                  30          


Gln Ile Gln Tyr Trp Gln Leu Ile Arg Trp Glu Asn Ala Ile Phe Phe 
        35                  40                  45              


Ala Ala Arg Glu His Gly Ile Gln Thr Leu Asn His Gln Val Val Pro 
    50                  55                  60                  


Ala Tyr Asn Ile Ser Lys Ser Lys Ala His Lys Ala Ile Glu Leu Gln 
65                  70                  75                  80  


Met Ala Leu Gln Gly Leu Ala Gln Ser Ala Tyr Lys Thr Glu Asp Trp 
                85                  90                  95      


Thr Leu Gln Asp Thr Cys Glu Glu Leu Trp Asn Thr Glu Pro Thr His 
            100                 105                 110         


Cys Phe Lys Lys Gly Gly Gln Thr Val Gln Val Tyr Phe Asp Gly Asn 
        115                 120                 125             


Lys Asp Asn Cys Met Thr Tyr Val Ala Trp Asp Ser Val Tyr Tyr Met 
    130                 135                 140                 


Thr Asp Ala Gly Thr Trp Asp Lys Thr Ala Thr Cys Val Ser His Arg 
145                 150                 155                 160 


Gly Leu Tyr Tyr Val Lys Glu Gly Tyr Asn Thr Phe Tyr Ile Glu Phe 
                165                 170                 175     


Lys Ser Glu Cys Glu Lys Tyr Gly Asn Thr Gly Thr Trp Glu Val His 
            180                 185                 190         


Phe Gly Asn Asn Val Ile Asp Cys Asn Asp Ser Met Cys Ser Thr Ser 
        195                 200                 205             


Asp Asp Thr Val Ser Ala Thr Gln Leu Val Lys Gln Leu Gln His Thr 
    210                 215                 220                 


Pro Ser Pro Tyr Ser Ser Thr Val Ser Val Gly Thr Ala Lys Thr Tyr 
225                 230                 235                 240 


Gly Gln Thr Ser Ala Ala Thr Arg Pro Gly His Cys Gly Leu Ala Glu 
                245                 250                 255     


Lys Gln His Cys Gly Pro Val Asn Pro Leu Leu Gly Ala Ala Thr Pro 
            260                 265                 270         


Thr Gly Asn Asn Lys Arg Arg Lys Leu Cys Ser Gly Asn Thr Thr Pro 
        275                 280                 285             


Ile Ile His Leu Lys Val Asp Arg Asn Ser Leu Met Arg Leu Arg Tyr 
    290                 295                 300                 


Arg Leu Arg Lys His Ser Asp His Tyr Arg Asp Ile Ser Ser Thr Trp 
305                 310                 315                 320 


His Trp Thr Gly Ala Gly Asn Glu Lys Thr Gly Ile Leu Thr Val Thr 
                325                 330                 335     


Tyr His Ser Glu Thr Gln Arg Thr Lys Phe Leu Asn Thr Val Ala Ile 
            340                 345                 350         


Pro Asp Ser Val Gln Ile Leu Val Gly Tyr Met Thr Met 
        355                 360                 365 


<210>  32
<211>  1095
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleotide sequence encoding HPV 18 E2 fragment 

<400>  32
atgcagaccc ccaaagagac actgagcgag cggctgagcg ccctgcagga caagatcatc       60

gaccactacg agaacgacag caaggacatc gacagccaga tccagtactg gcagctgatc      120

agatgggaga acgccatctt cttcgccgcc agagagcacg gcatccagac cctgaaccac      180

caggtggtgc ccgcctacaa catcagcaag agcaaggccc acaaggctat cgagctgcag      240

atggccctgc agggactggc ccagagcgcc tacaagaccg aggactggac cctgcaggat      300

acctgcgagg aactgtggaa caccgagccc acccactgct tcaagaaagg cggccagacc      360

gtgcaggtgt acttcgacgg caacaaggac aactgcatga cctacgtggc ctgggacagc      420

gtgtactaca tgaccgacgc cggcacctgg gacaagaccg ccacctgtgt gtcccaccgg      480

ggcctgtact acgtgaaaga gggctacaac accttctaca tcgagttcaa gagcgagtgc      540

gagaagtacg gcaacaccgg cacatgggag gtgcacttcg gcaacaacgt gatcgactgc      600

aacgacagca tgtgcagcac cagcgacgac accgtgtccg ccacccagct ggtgaaacag      660

ctgcagcaca cccccagccc ctacagcagc accgtgtctg tgggcaccgc caagacctac      720

ggccagacca gcgccgccac cagacctgga cactgtggcc tggccgagaa gcagcactgc      780

ggccctgtga accctctgct gggagccgcc acccccaccg gcaacaacaa gcggagaaag      840

ctgtgcagcg gcaacaccac ccccatcatc cacctgaagg tggaccggaa cagcctgatg      900

cggctgcggt acagactgcg gaagcacagc gaccactacc gggacatcag cagcacctgg      960

cactggaccg gcgctggcaa cgagaaaacc ggcatcctga ccgtgaccta ccacagcgaa     1020

acccagcgga ccaagttcct gaacaccgtg gccatccccg acagcgtgca gatcctggtg     1080

ggatatatga ccatg                                                      1095


<210>  33
<211>  1095
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleotide sequence encoding HPV 18 E2 fragment 

<400>  33
atgcagacgc cgaaagaaac cctgtccgag agactgagcg ctctccaaga taagattatt       60

gatcactatg agaatgactc caaggacatt gattcccaga ttcagtattg gcaacttatt      120

cgctgggaaa atgccatctt ctttgccgct cgggaacacg ggattcagac actgaatcat      180

caagtggtcc cagcctacaa tatctccaag tccaaagccc acaaagctat cgaactccaa      240

atggctctcc agggactggc tcagtccgct tataagacag aagattggac actccaggac      300

acgtgtgaag aactctggaa taccgaaccg acgcactgtt ttaagaaggg tggacagaca      360

gttcaagtct actttgatgg gaacaaagat aattgcatga catatgtcgc ttgggattcc      420

gtctactata tgacagatgc tgggacgtgg gataagacag ccacatgcgt cagccacaga      480

gggctgtact atgtcaaaga agggtataat acgttctata tcgagtttaa gtctgaatgc      540

gagaaatatg ggaatacggg aacctgggaa gtgcattttg ggaacaatgt catcgattgc      600

aatgactcca tgtgctccac ctccgatgac acagtcagcg ccacacagct cgtgaaacag      660

ctccagcata caccatctcc ctactcctcc actgtgtccg tgggaacagc caaaacatat      720

ggacagacct ccgctgccac acggcctggc cattgcggac tggccgagaa acagcattgt      780

ggaccagtca accctctgct gggagctgct actccaacag ggaacaacaa gaggcggaaa      840

ctgtgttccg gcaatacgac acctatcatt cacctcaagg tcgacagaaa ctccctgatg      900

agactgagat accggctgag aaagcactcc gatcactaca gagatatcag ctctacttgg      960

cattggacag gtgctggaaa cgaaaagaca gggatcctga cagtgacgta tcactccgag     1020

actcagcgca ccaaatttct caatactgtg gccattcccg attccgtgca gattcttgtc     1080

ggatatatga cgatg                                                      1095


