                         SEQUENCE LISTING

<110>  MAB Discovery GmbH
 
<120>  Humanized anti-IL-1R3 antibodies

<130>  B198-0007WO1

<160>  175   

<170>  PatentIn version 3.5

<210>  1
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody

<400>  1

Glu Val Gln Leu Glu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser Ser Ser 
            20                  25                  30          


Tyr Trp Ile Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Val Ser Cys Ile Tyr Thr Gly Ser Gly Gly Thr Tyr Tyr Ala Ser Trp 
    50                  55                  60                  


Glu Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu 
65                  70                  75                  80  


Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Phe 
                85                  90                  95      


Cys Ala Arg Asp Pro Gly Tyr Ser Ser Trp Leu Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  2
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody

<400>  2

Glu Val Gln Leu Glu Glu Ser Gly Gly Asp Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser Ser Ser 
            20                  25                  30          


His Tyr Met Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Val Ser Cys Ile Tyr Ala Gly Ser Ser Gly Asn Thr Tyr Tyr Ala Asn 
    50                  55                  60                  


Trp Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Phe Cys Ala Arg Val Asp Ala Ser Ser Ser Gly Ser Trp Asp Leu Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  3
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody

<400>  3

Glu Val Gln Leu Glu Glu Ser Gly Gly Arg Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Ile Asp Leu Ser Ser Tyr 
            20                  25                  30          


Ala Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Tyr Val 
        35                  40                  45              


Ser Val Ile Thr Ser Ser Ala Thr Thr Tyr Tyr Ala Ser Trp Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Phe Cys Ala 
                85                  90                  95      


Arg Gly Gly Pro Gly Tyr Ser Thr Asn Thr His Tyr Ala Phe Asp Pro 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210>  4
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody

<400>  4

Glu Val Gln Leu Glu Glu Ser Gly Gly Arg Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Ile Asp Leu Asp Asn Tyr 
            20                  25                  30          


Ala Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Tyr Val 
        35                  40                  45              


Ala Val Ile Ser Ser Asp Gly Phe Phe Tyr Asp Ala Ser Trp Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Phe Cys Ala 
                85                  90                  95      


Arg Asp Arg Gly Thr Ser Thr Gly Ser Leu Asp Leu Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  5
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody

<400>  5

Glu Val Gln Leu Glu Glu Ser Gly Gly Arg Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu Ser Ser Tyr 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ile Ile Ser Gly Ser Ala Ser Thr Tyr Tyr Ala Thr Trp Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Phe Cys Ala 
                85                  90                  95      


Arg Thr His Tyr Ala Ala Val Ala Gly Tyr Gly Tyr Ala Ser Arg Leu 
            100                 105                 110         


Asp Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  6
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody

<400>  6

Glu Val Gln Leu Glu Glu Ser Gly Gly Asp Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser Ser Asn 
            20                  25                  30          


Tyr Trp Ile Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Leu 
        35                  40                  45              


Val Ser Cys Ile Tyr Thr Ser Thr Gly Asn Thr Trp Tyr Ala Ser Trp 
    50                  55                  60                  


Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu 
65                  70                  75                  80  


Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Phe 
                85                  90                  95      


Cys Ala Arg Asp Leu Leu Val Val Thr Ser Phe Asn Leu Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  7
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody

<400>  7

Glu Val Gln Leu Glu Glu Ser Gly Gly Asp Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser Ser Ser 
            20                  25                  30          


Tyr Tyr Met Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Val Ser Cys Ile Tyr Ala Gly Ser Ser Gly Val Thr Tyr Tyr Ala Ser 
    50                  55                  60                  


Trp Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Phe Cys Ala Ser Glu Thr Asp Gly Asn Tyr Phe Asn Leu Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  8
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody

<400>  8

Glu Val Gln Leu Glu Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu Ser Thr Ser 
            20                  25                  30          


Tyr Trp Arg Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Val Ser Cys Ile Tyr Ala Gly Ser Gly Asp Val Thr Tyr Tyr Ala Asn 
    50                  55                  60                  


Trp Val Asn Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Ser Gly Val Gly Phe Gly Tyr Phe Asn Leu Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  9
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody

<400>  9

Glu Val Gln Leu Glu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ile Asp Phe Ser Ser Tyr 
            20                  25                  30          


Tyr Tyr Met Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Val Ser Cys Ile Phe Ile Gly Tyr Gly Asp Val Thr Trp Tyr Ala Ser 
    50                  55                  60                  


Trp Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Phe Cys Ala Arg Ala Leu Gly Ser Ser Gly Tyr Arg Val Asn Leu Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  10
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody

<400>  10

Glu Val Gln Leu Glu Glu Ser Gly Gly Arg Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu Ser Ser Tyr 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Met Ile Tyr Gly Ser Gly Tyr Thr Tyr Tyr Ala Ser Trp Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Phe Cys Ala 
                85                  90                  95      


Arg Asp Pro Gln Tyr Phe Ile Leu Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  11
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody

<400>  11

Glu Val Gln Leu Glu Glu Ser Gly Gly Arg Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Phe Ser Leu Ser Ser Tyr 
            20                  25                  30          


Asp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Tyr Ile Gly Gly Thr Thr Ala Tyr Ala Ser Trp Pro Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Phe Cys Ala 
                85                  90                  95      


Arg Leu Gln Gly Ala Asn Tyr Tyr Asn Ser Leu Ala Leu Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  12
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody

<400>  12

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asp Phe Ser Ser Asn 
            20                  25                  30          


Tyr Tyr Met Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Leu 
        35                  40                  45              


Val Ser Cys Ile Tyr Thr Asn Ser Gly Asn Thr Trp Ser Ala Ser Trp 
    50                  55                  60                  


Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu 
65                  70                  75                  80  


Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Phe 
                85                  90                  95      


Cys Ala Arg Asp Leu Asn Tyr Pro Asp Thr Ser Asn Leu Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  13
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody

<400>  13

Glu Val Gln Leu Glu Glu Ser Gly Gly Asp Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser Phe Gly 
            20                  25                  30          


Tyr Tyr Met Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Val Ser Cys Ile Tyr Gly Asp Ser Ser Asp Thr Leu Tyr Ala Asn Trp 
    50                  55                  60                  


Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu 
65                  70                  75                  80  


Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Phe 
                85                  90                  95      


Cys Ala Arg Tyr Pro Gly Gly Ser Tyr Tyr Asn Leu Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  14
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody

<400>  14

Glu Val Gln Leu Glu Glu Ser Gly Gly Asp Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser Ser Thr 
            20                  25                  30          


Tyr Tyr Met Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Val Ser Cys Ile Tyr Ala Gly Ser Ser Gly Ser Thr Tyr Tyr Ala Ser 
    50                  55                  60                  


Trp Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Phe Cys Ala Arg Val Asp Gly Ser Ser Ser Gly Ser Trp Asp Leu Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  15
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody

<400>  15

Glu Val Gln Leu Glu Glu Ser Gly Gly Asp Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ile Ser Phe Ser Ser Ser 
            20                  25                  30          


Asp Phe Met Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Val Ser Cys Ile Tyr Ala Gly Ser Ser Val Ser Ile Tyr Tyr Ala Thr 
    50                  55                  60                  


Trp Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Phe Cys Ala Arg Ser Thr Gly Ser Val Gly Arg Gly Phe Asn Leu Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  16
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody

<400>  16

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser Ser Ile 
            20                  25                  30          


Tyr Tyr Met Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Val Ser Cys Ile Tyr Thr Gly Asn Ser Asp Phe Thr Tyr Tyr Ala Asn 
    50                  55                  60                  


Trp Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Phe Cys Ala Arg Phe Arg Asp Asp Tyr Ala Ser Leu Lys Leu Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  17
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody

<400>  17

Glu Val Gln Leu Glu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser Ser Gly 
            20                  25                  30          


Tyr Asp Met Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Val Ser Cys Ile Tyr Thr Gly Ser Gly Ser Thr Tyr Tyr Ala Asn Trp 
    50                  55                  60                  


Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu 
65                  70                  75                  80  


Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Phe 
                85                  90                  95      


Cys Ala Arg Asn Ser Asn Asp Trp Met Tyr Phe Asn Leu Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  18
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody

<400>  18

Glu Val Gln Leu Glu Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser Ser Ser 
            20                  25                  30          


Tyr Trp Ile Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Val Ala Cys Ile Tyr Thr Gly Ser Gly Gly Thr Tyr Tyr Ala Ser Trp 
    50                  55                  60                  


Glu Lys Gly Arg Phe Thr Ile Ser Lys Thr Ser Ser Thr Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Asp Pro Gly Tyr Ser Ser Trp Leu Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  19
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody

<400>  19

Glu Val Gln Leu Glu Glu Ser Gly Gly Asp Leu Val Gln Pro Gly Ala 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser Ser Ser 
            20                  25                  30          


His Tyr Met Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Val Ala Cys Ile Tyr Ala Gly Ser Ser Gly Asn Thr Tyr Tyr Ala Asn 
    50                  55                  60                  


Trp Ala Lys Gly Arg Phe Thr Ile Ser Lys Thr Asn Ser Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Phe Cys Ala Arg Val Asp Ala Ser Ser Ser Gly Ser Trp Asp Leu Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  20
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody

<400>  20

Glu Val Gln Leu Leu Glu Ser Gly Gly Arg Leu Val Gln Pro Gly Thr 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Ile Asp Leu Ser Ser Tyr 
            20                  25                  30          


Ala Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Tyr Val 
        35                  40                  45              


Gly Val Ile Thr Ser Ser Ala Thr Thr Tyr Tyr Ala Ser Trp Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Lys Thr Ser Ser Thr Thr Leu Tyr Leu Gln 
65                  70                  75                  80  


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Phe Cys Ala Arg 
                85                  90                  95      


Gly Gly Pro Gly Tyr Ser Thr Asn Thr His Tyr Ala Phe Asp Pro Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  21
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody

<400>  21

Glu Val Gln Leu Glu Glu Ser Gly Gly Arg Val Val Gln Pro Gly Thr 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Ile Asp Leu Asp Asn Tyr 
            20                  25                  30          


Ala Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Tyr Val 
        35                  40                  45              


Ala Val Ile Ser Ser Asp Gly Phe Phe Tyr Asp Ala Ser Trp Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Lys Ala Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Phe Cys Ala 
                85                  90                  95      


Arg Asp Arg Gly Thr Ser Thr Gly Ser Leu Asp Leu Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  22
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody

<400>  22

Gln Val Gln Leu Glu Glu Ser Gly Gly Arg Leu Val Gln Pro Gly Thr 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu Ser Ser Tyr 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ile Ile Ser Gly Ser Ala Ser Thr Tyr Tyr Ala Thr Trp Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Lys Thr Ser Thr Thr Leu Tyr Leu Gln Met 
65                  70                  75                  80  


Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Phe Cys Ala Arg Thr 
                85                  90                  95      


His Tyr Ala Ala Val Ala Gly Tyr Gly Tyr Ala Ser Arg Leu Asp Leu 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210>  23
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody

<400>  23

Gln Val Gln Leu Gln Glu Ser Gly Gly Asp Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser Ser Asn 
            20                  25                  30          


Tyr Trp Ile Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Leu 
        35                  40                  45              


Val Ala Cys Ile Tyr Thr Ser Thr Gly Asn Thr Trp Tyr Ala Ser Trp 
    50                  55                  60                  


Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu 
65                  70                  75                  80  


Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Phe 
                85                  90                  95      


Cys Ala Arg Asp Leu Leu Val Val Thr Ser Phe Asn Leu Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  24
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody

<400>  24

Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Gln Pro Gly Ala 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser Ser Ser 
            20                  25                  30          


Tyr Tyr Met Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Val Ala Cys Ile Tyr Ala Gly Ser Ser Gly Val Thr Tyr Tyr Ala Ser 
    50                  55                  60                  


Trp Ala Lys Gly Arg Phe Thr Ile Ser Asp Thr Ser Ser Thr Thr Leu 
65                  70                  75                  80  


Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Phe 
                85                  90                  95      


Cys Ala Ser Glu Thr Asp Gly Asn Tyr Phe Asn Leu Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  25
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody

<400>  25

Glu Val Gln Leu Glu Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu Ser Thr Ser 
            20                  25                  30          


Tyr Trp Arg Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Val Ala Cys Ile Tyr Ala Gly Ser Gly Asp Val Thr Tyr Tyr Ala Asn 
    50                  55                  60                  


Trp Val Asn Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Ser Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Ser Gly Val Gly Phe Gly Tyr Phe Asn Leu Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  26
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody

<400>  26

Glu Val Gln Leu Glu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ile Asp Phe Ser Ser Tyr 
            20                  25                  30          


Tyr Tyr Met Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Val Ala Cys Ile Phe Ile Gly Tyr Gly Asp Val Thr Trp Tyr Ala Ser 
    50                  55                  60                  


Trp Ala Lys Gly Arg Phe Thr Ile Ser Lys Ala Asn Ser Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Phe Cys Ala Arg Ala Leu Gly Ser Ser Gly Tyr Arg Val Asn Leu Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  27
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody

<400>  27

Gln Val Gln Leu Glu Glu Ser Gly Gly Arg Leu Val Gln Pro Gly Ala 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu Ser Ser Tyr 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Met Ile Tyr Gly Ser Gly Tyr Thr Tyr Tyr Ala Ser Trp Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Thr Thr Ser Thr Thr Leu Tyr Leu Gln Met 
65                  70                  75                  80  


Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Phe Cys Ala Arg Asp 
                85                  90                  95      


Pro Gln Tyr Phe Ile Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         


Ser 
    


<210>  28
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody

<400>  28

Glu Val Gln Leu Glu Glu Ser Gly Gly Arg Leu Val Gln Pro Gly Thr 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Phe Ser Leu Ser Ser Tyr 
            20                  25                  30          


Asp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Tyr Ile Gly Gly Thr Thr Ala Tyr Ala Ser Trp Pro Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Lys Thr Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Phe Cys Ala 
                85                  90                  95      


Arg Leu Gln Gly Ala Asn Tyr Tyr Asn Ser Leu Ala Leu Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  29
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody

<400>  29

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asp Phe Ser Ser Asn 
            20                  25                  30          


Tyr Tyr Met Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Leu 
        35                  40                  45              


Val Ala Cys Ile Tyr Thr Asn Ser Gly Asn Thr Trp Ser Ala Ser Trp 
    50                  55                  60                  


Ala Lys Gly Arg Phe Thr Ile Ser Lys Thr Asn Ser Thr Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Asp Leu Asn Tyr Pro Asp Thr Ser Asn Leu Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  30
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody

<400>  30

Glu Val Gln Leu Glu Glu Ser Gly Gly Asp Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser Phe Gly 
            20                  25                  30          


Tyr Tyr Met Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Val Ala Cys Ile Tyr Gly Asp Ser Ser Asp Thr Leu Tyr Ala Asn Trp 
    50                  55                  60                  


Ala Lys Gly Arg Phe Thr Ile Ser Lys Thr Asn Ser Lys Asn Thr Leu 
65                  70                  75                  80  


Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Phe 
                85                  90                  95      


Cys Ala Arg Tyr Pro Gly Gly Ser Tyr Tyr Asn Leu Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  31
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody

<400>  31

Gln Val Gln Leu Gln Glu Ser Gly Gly Asp Leu Val Gln Pro Gly Ala 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser Ser Thr 
            20                  25                  30          


Tyr Tyr Met Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Val Ala Cys Ile Tyr Ala Gly Ser Ser Gly Ser Thr Tyr Tyr Ala Ser 
    50                  55                  60                  


Trp Ala Lys Gly Arg Phe Thr Ile Ser Lys Asn Ser Ser Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Val Asp Gly Ser Ser Ser Gly Ser Trp Asp Leu Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  32
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody

<400>  32

Glu Val Gln Leu Glu Glu Ser Gly Gly Asp Leu Val Gln Pro Gly Ala 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ile Ser Phe Ser Ser Ser 
            20                  25                  30          


Asp Phe Met Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Val Ala Cys Ile Tyr Ala Gly Ser Ser Val Ser Ile Tyr Tyr Ala Thr 
    50                  55                  60                  


Trp Ala Lys Gly Arg Phe Thr Ile Ser Lys Ala Ser Ser Thr Thr Leu 
65                  70                  75                  80  


Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Phe 
                85                  90                  95      


Cys Ala Arg Ser Thr Gly Ser Val Gly Arg Gly Phe Asn Leu Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  33
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody

<400>  33

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser Ser Ile 
            20                  25                  30          


Tyr Tyr Met Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Val Gly Cys Ile Tyr Thr Gly Asn Ser Asp Phe Thr Tyr Tyr Ala Asn 
    50                  55                  60                  


Trp Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Ser Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Phe Cys Ala Arg Phe Arg Asp Asp Tyr Ala Ser Leu Lys Leu Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  34
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody

<400>  34

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Ser Phe Ser Ser Gly 
            20                  25                  30          


Tyr Asp Met Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Val Gly Cys Ile Tyr Thr Gly Ser Gly Ser Thr Tyr Tyr Ala Asn Trp 
    50                  55                  60                  


Ala Lys Gly Arg Phe Thr Ile Ser Lys Asp Asn Ser Lys Thr Thr Leu 
65                  70                  75                  80  


Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Phe 
                85                  90                  95      


Cys Ala Arg Asn Ser Asn Asp Trp Met Tyr Phe Asn Leu Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  35
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody

<400>  35

Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Glu Ser Ile Ser Asn Tyr 
            20                  25                  30          


Leu Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Leu Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Asn Trp Trp Val Ile Glu His 
                85                  90                  95      


Asn Gly Ala Ala Phe Gly Gly Gly Thr Lys Val Val Ile Lys 
            100                 105                 110 


<210>  36
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody

<400>  36

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Glu Ser Ile Tyr Ser Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Leu Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Ser Ala Ser Tyr Ser Thr Gly 
                85                  90                  95      


Pro Asp Trp Thr Phe Gly Gln Gly Thr Lys Val Val Ile Lys 
            100                 105                 110 


<210>  37
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody

<400>  37

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Ser Ile Tyr Ile Tyr 
            20                  25                  30          


Leu Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Ala Thr Thr Tyr Asn 
                85                  90                  95      


Val Asp Asn Val Phe Gly Gln Gly Thr Lys Val Val Ile Lys 
            100                 105                 110 


<210>  38
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody

<400>  38

Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Glu Asn Ile Gly Asn Gly 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Cys Thr Tyr Trp Asn Pro Asp 
                85                  90                  95      


Tyr Ile Gly Gly Ala Phe Gly Gly Gly Thr Lys Val Val Ile Lys 
            100                 105                 110     


<210>  39
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody

<400>  39

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Leu Ala Ser Glu Asp Ile Tyr Ser Gly 
            20                  25                  30          


Ile Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Asn Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gly Gly Tyr Ser Tyr Ser Asn 
                85                  90                  95      


Thr Gly Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110 


<210>  40
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody

<400>  40

Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Glu Asp Ile Tyr Ser Asn 
            20                  25                  30          


Leu Ala Trp Phe Gln Gln Lys Pro Gly Gln Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gly Val Cys Thr Asp Ile Ser 
                85                  90                  95      


Thr Asp Asp Leu Tyr Asn Ala Phe Gly Gln Gly Thr Lys Val Val Ile 
            100                 105                 110         


Lys 
    


<210>  41
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody

<400>  41

Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Glu Asp Ile Tyr Ser Asn 
            20                  25                  30          


Leu Ala Trp Phe Gln Gln Lys Pro Gly Gln Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Arg Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gly Val Tyr Thr Tyr Ser Thr 
                85                  90                  95      


Asp Ile His Ala Phe Gly Gly Gly Thr Lys Val Val Ile Lys 
            100                 105                 110 


<210>  42
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody

<400>  42

Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Glu Asp Ile Tyr Ser Asn 
            20                  25                  30          


Leu Ala Trp Phe Gln Gln Lys Pro Gly Gln Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gly Val Tyr Thr His Ile Ser 
                85                  90                  95      


Ala Asp Asn Ala Phe Gly Gly Gly Thr Lys Val Val Ile Lys 
            100                 105                 110 


<210>  43
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody

<400>  43

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Glu Asn Ile Tyr Ser Ser 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asp Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Tyr Tyr Ser Gly Gly 
                85                  90                  95      


Thr Asp Asn Asp Val Phe Gly Gly Gly Thr Lys Val Val Ile Lys 
            100                 105                 110     


<210>  44
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody

<400>  44

Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ser Ser Gln Ser Val Asp Gly Asn 
            20                  25                  30          


Asn Leu Leu Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Asp Ala Ser Asn Leu Ala Ser Gly Val Pro Ser Arg Phe 
    50                  55                  60                  


Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu 
65                  70                  75                  80  


Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gly Ser Tyr Tyr Ser 
                85                  90                  95      


Ser Ser Trp Tyr Asn Val Phe Gly Gln Gly Thr Lys Val Val Ile Lys 
            100                 105                 110         


<210>  45
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody

<400>  45

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Ser Ile Tyr Ser Phe 
            20                  25                  30          


Leu Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Asp Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Cys Asn Tyr Ile Ile Asp Tyr 
                85                  90                  95      


Gly Ala Phe Gly Gln Gly Thr Lys Val Val Ile Lys 
            100                 105             


<210>  46
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody

<400>  46

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Ser Ile Gly Tyr Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Arg Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Ser Tyr Tyr Asn Ser Asp Ser 
                85                  90                  95      


Asp Ala Phe Gly Gln Gly Thr Lys Val Val Ile Lys 
            100                 105             


<210>  47
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody

<400>  47

Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Thr Ile Ser Ile Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Tyr Thr Glu Asp Asn 
                85                  90                  95      


Ile Asp Asn Thr Phe Gly Gln Gly Thr Lys Val Val Ile Lys 
            100                 105                 110 


<210>  48
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody

<400>  48

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asn Ile Tyr Ser Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Leu Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gly Ala Val Tyr Ser Gly Asn 
                85                  90                  95      


Thr Glu Trp Ala Phe Gly Gln Gly Thr Lys Val Val Ile Lys 
            100                 105                 110 


<210>  49
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody

<400>  49

Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Ser Val Tyr Asn Ser 
            20                  25                  30          


Asn His Leu Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Ser Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe 
    50                  55                  60                  


Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu 
65                  70                  75                  80  


Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gly Glu Phe Ser Cys 
                85                  90                  95      


Val Ser Ala Asp Cys Ile Ala Phe Gly Gly Gly Thr Lys Val Val Ile 
            100                 105                 110         


Lys 
    


<210>  50
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody

<400>  50

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Cys Thr Tyr Tyr Asp Asn Asn 
                85                  90                  95      


Tyr Gly Gly Ala Phe Gly Gly Gly Thr Lys Val Val Ile Lys 
            100                 105                 110 


<210>  51
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody

<400>  51

Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Glu Ser Ile Ser Ala Asn 
            20                  25                  30          


Tyr Trp Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Thr Tyr Phe Cys Gln Ser Trp Tyr Tyr Ser Gly 
                85                  90                  95      


Ser Gly Ser Tyr His Ser Trp Ala Phe Gly Gln Gly Thr Lys Val Val 
            100                 105                 110         


Ile Lys 
        


<210>  52
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody

<400>  52

Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Glu Ser Ile Ser Asn Tyr 
            20                  25                  30          


Leu Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Leu Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Asn Trp Trp Val Ile Glu His 
                85                  90                  95      


Asn Gly Ala Ala Phe Gly Gly Gly Thr Lys Val Val Ile Lys 
            100                 105                 110 


<210>  53
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody

<400>  53

Ala Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Glu Ser Ile Tyr Ser Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Leu Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Ser Ala Ser Tyr Ser Thr Gly 
                85                  90                  95      


Pro Asp Trp Thr Phe Gly Gln Gly Thr Lys Val Val Ile Lys 
            100                 105                 110 


<210>  54
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody

<400>  54

Ala Ile Arg Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Ser Ile Tyr Ile Tyr 
            20                  25                  30          


Leu Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Ala Thr Thr Tyr Asn 
                85                  90                  95      


Val Asp Asn Val Phe Gly Gln Gly Thr Lys Val Val Ile Lys 
            100                 105                 110 


<210>  55
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody

<400>  55

Glu Leu Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Glu Asn Ile Gly Asn Gly 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Cys Thr Tyr Trp Asn Pro Asp 
                85                  90                  95      


Tyr Ile Gly Gly Ala Phe Gly Gly Gly Thr Lys Val Val Ile Lys 
            100                 105                 110     


<210>  56
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody

<400>  56

Ala Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Leu Ala Ser Glu Asp Ile Tyr Ser Gly 
            20                  25                  30          


Ile Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Asn Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gly Gly Tyr Ser Tyr Ser Asn 
                85                  90                  95      


Thr Gly Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110 


<210>  57
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody

<400>  57

Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Glu Asp Ile Tyr Ser Asn 
            20                  25                  30          


Leu Ala Trp Phe Gln Gln Lys Pro Gly Gln Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gly Val Cys Thr Asp Ile Ser 
                85                  90                  95      


Thr Asp Asp Leu Tyr Asn Ala Phe Gly Gln Gly Thr Lys Val Val Ile 
            100                 105                 110         


Lys 
    


<210>  58
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody

<400>  58

Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Glu Asp Ile Tyr Ser Asn 
            20                  25                  30          


Leu Ala Trp Phe Gln Gln Lys Pro Gly Gln Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Arg Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gly Val Tyr Thr Tyr Ser Thr 
                85                  90                  95      


Asp Ile His Ala Phe Gly Gly Gly Thr Lys Val Val Ile Lys 
            100                 105                 110 


<210>  59
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody

<400>  59

Glu Leu Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Glu Asp Ile Tyr Ser Asn 
            20                  25                  30          


Leu Ala Trp Phe Gln Gln Lys Pro Gly Gln Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gly Val Tyr Thr His Ile Ser 
                85                  90                  95      


Ala Asp Asn Ala Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110 


<210>  60
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody

<400>  60

Ala Leu Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Glu Asn Ile Tyr Ser Ser 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asp Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Tyr Tyr Ser Gly Gly 
                85                  90                  95      


Thr Asp Asn Asp Val Phe Gly Gly Gly Thr Lys Val Val Ile Lys 
            100                 105                 110     


<210>  61
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody

<400>  61

Asn Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ser Ser Gln Ser Val Asp Gly Asn 
            20                  25                  30          


Asn Leu Leu Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Asp Ala Ser Asn Leu Ala Ser Gly Val Pro Ser Arg Phe 
    50                  55                  60                  


Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu 
65                  70                  75                  80  


Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gly Ser Tyr Tyr Ser 
                85                  90                  95      


Ser Ser Trp Tyr Asn Val Phe Gly Gln Gly Thr Lys Val Val Ile Lys 
            100                 105                 110         


<210>  62
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody

<400>  62

Asp Val Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Ser Ile Tyr Ser Phe 
            20                  25                  30          


Leu Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Asp Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Cys Asn Tyr Ile Ile Asp Tyr 
                85                  90                  95      


Gly Ala Phe Gly Gln Gly Thr Lys Val Val Ile Lys 
            100                 105             


<210>  63
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody

<400>  63

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Ser Ile Gly Tyr Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Arg Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Ser Tyr Tyr Asn Ser Asp Ser 
                85                  90                  95      


Asp Ala Phe Gly Gln Gly Thr Lys Val Val Ile Lys 
            100                 105             


<210>  64
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody

<400>  64

Ala Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Thr Ile Ser Ile Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Tyr Thr Glu Asp Asn 
                85                  90                  95      


Ile Asp Asn Thr Phe Gly Gln Gly Thr Lys Val Val Ile Lys 
            100                 105                 110 


<210>  65
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody

<400>  65

Ala Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asn Ile Tyr Ser Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Leu Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gly Ala Val Tyr Ser Gly Asn 
                85                  90                  95      


Thr Glu Trp Ala Phe Gly Gln Gly Thr Lys Val Val Ile Lys 
            100                 105                 110 


<210>  66
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody

<400>  66

Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Ser Val Tyr Asn Ser 
            20                  25                  30          


Asn His Leu Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Ser Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe 
    50                  55                  60                  


Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu 
65                  70                  75                  80  


Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gly Glu Phe Ser Cys 
                85                  90                  95      


Val Ser Ala Asp Cys Ile Ala Phe Gly Gly Gly Thr Lys Val Val Ile 
            100                 105                 110         


Lys 
    


<210>  67
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody

<400>  67

Asp Val Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Cys Thr Tyr Tyr Asp Asn Asn 
                85                  90                  95      


Tyr Gly Gly Ala Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110 


<210>  68
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody

<400>  68

Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Glu Ser Ile Ser Ala Asn 
            20                  25                  30          


Tyr Trp Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Thr Tyr Phe Cys Gln Ser Trp Tyr Tyr Ser Gly 
                85                  90                  95      


Ser Gly Ser Tyr His Ser Trp Ala Phe Gly Gln Gly Thr Lys Val Val 
            100                 105                 110         


Ile Lys 
        


<210>  69
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody

<400>  69

Ser Ser Tyr Trp Ile Cys 
1               5       


<210>  70
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody

<400>  70

Ser Ser His Tyr Met Cys 
1               5       


<210>  71
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody

<400>  71

Ser Tyr Ala Met Gly 
1               5   


<210>  72
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody

<400>  72

Asn Tyr Ala Met Gly 
1               5   


<210>  73
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody

<400>  73

Ser Tyr Tyr Met Ser 
1               5   


<210>  74
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody

<400>  74

Ser Asn Tyr Trp Ile Cys 
1               5       


<210>  75
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody

<400>  75

Ser Ser Tyr Tyr Met Cys 
1               5       


<210>  76
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody

<400>  76

Thr Ser Tyr Trp Arg Cys 
1               5       


<210>  77
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody

<400>  77

Ser Tyr Tyr Tyr Met Cys 
1               5       


<210>  78
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody

<400>  78

Ser Tyr Trp Met Ser 
1               5   


<210>  79
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody

<400>  79

Ser Tyr Asp Met Ser 
1               5   


<210>  80
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody

<400>  80

Ser Asn Tyr Tyr Met Cys 
1               5       


<210>  81
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody

<400>  81

Phe Gly Tyr Tyr Met Cys 
1               5       


<210>  82
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody

<400>  82

Ser Thr Tyr Tyr Met Cys 
1               5       


<210>  83
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody

<400>  83

Ser Ser Asp Phe Met Cys 
1               5       


<210>  84
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody

<400>  84

Ser Ile Tyr Tyr Met Cys 
1               5       


<210>  85
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody

<400>  85

Ser Gly Tyr Asp Met Cys 
1               5       


<210>  86
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody

<400>  86

Cys Ile Tyr Thr Gly Ser Gly Gly Thr Tyr Tyr Ala Ser Trp Glu Lys 
1               5                   10                  15      


Gly 
    


<210>  87
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody

<400>  87

Cys Ile Tyr Ala Gly Ser Ser Gly Asn Thr Tyr Tyr Ala Asn Trp Ala 
1               5                   10                  15      


Lys Gly 
        


<210>  88
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody

<400>  88

Val Ile Thr Ser Ser Ala Thr Thr Tyr Tyr Ala Ser Trp Ala Lys Gly 
1               5                   10                  15      


<210>  89
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody

<400>  89

Val Ile Ser Ser Asp Gly Phe Phe Tyr Asp Ala Ser Trp Ala Lys Gly 
1               5                   10                  15      


<210>  90
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody

<400>  90

Ile Ile Ser Gly Ser Ala Ser Thr Tyr Tyr Ala Thr Trp Ala Lys Gly 
1               5                   10                  15      


<210>  91
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody

<400>  91

Cys Ile Tyr Thr Ser Thr Gly Asn Thr Trp Tyr Ala Ser Trp Ala Lys 
1               5                   10                  15      


Gly 
    


<210>  92
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody

<400>  92

Cys Ile Tyr Ala Gly Ser Ser Gly Val Thr Tyr Tyr Ala Ser Trp Ala 
1               5                   10                  15      


Lys Gly 
        


<210>  93
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody

<400>  93

Cys Ile Tyr Ala Gly Ser Gly Asp Val Thr Tyr Tyr Ala Asn Trp Val 
1               5                   10                  15      


Asn Gly 
        


<210>  94
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody

<400>  94

Cys Ile Phe Ile Gly Tyr Gly Asp Val Thr Trp Tyr Ala Ser Trp Ala 
1               5                   10                  15      


Lys Gly 
        


<210>  95
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody

<400>  95

Met Ile Tyr Gly Ser Gly Tyr Thr Tyr Tyr Ala Ser Trp Ala Lys Gly 
1               5                   10                  15      


<210>  96
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody

<400>  96

Thr Ile Tyr Ile Gly Gly Thr Thr Ala Tyr Ala Ser Trp Pro Lys Gly 
1               5                   10                  15      


<210>  97
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody

<400>  97

Cys Ile Tyr Thr Asn Ser Gly Asn Thr Trp Ser Ala Ser Trp Ala Lys 
1               5                   10                  15      


Gly 
    


<210>  98
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody

<400>  98

Cys Ile Tyr Gly Asp Ser Ser Asp Thr Leu Tyr Ala Asn Trp Ala Lys 
1               5                   10                  15      


Gly 
    


<210>  99
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody

<400>  99

Cys Ile Tyr Ala Gly Ser Ser Gly Ser Thr Tyr Tyr Ala Ser Trp Ala 
1               5                   10                  15      


Lys Gly 
        


<210>  100
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody

<400>  100

Cys Ile Tyr Ala Gly Ser Ser Val Ser Ile Tyr Tyr Ala Thr Trp Ala 
1               5                   10                  15      


Lys Gly 
        


<210>  101
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody

<400>  101

Cys Ile Tyr Thr Gly Asn Ser Asp Phe Thr Tyr Tyr Ala Asn Trp Ala 
1               5                   10                  15      


Lys Gly 
        


<210>  102
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody

<400>  102

Cys Ile Tyr Thr Gly Ser Gly Ser Thr Tyr Tyr Ala Asn Trp Ala Lys 
1               5                   10                  15      


Gly 
    


<210>  103
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody

<400>  103

Asp Pro Gly Tyr Ser Ser Trp Leu 
1               5               


<210>  104
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody

<400>  104

Val Asp Ala Ser Ser Ser Gly Ser Trp Asp Leu 
1               5                   10      


<210>  105
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody

<400>  105

Gly Gly Pro Gly Tyr Ser Thr Asn Thr His Tyr Ala Phe Asp Pro 
1               5                   10                  15  


<210>  106
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody

<400>  106

Asp Arg Gly Thr Ser Thr Gly Ser Leu Asp Leu 
1               5                   10      


<210>  107
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody

<400>  107

Thr His Tyr Ala Ala Val Ala Gly Tyr Gly Tyr Ala Ser Arg Leu Asp 
1               5                   10                  15      


Leu 
    


<210>  108
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody

<400>  108

Asp Leu Leu Val Val Thr Ser Phe Asn Leu 
1               5                   10  


<210>  109
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody

<400>  109

Glu Thr Asp Gly Asn Tyr Phe Asn Leu 
1               5                   


<210>  110
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody

<400>  110

Gly Val Gly Phe Gly Tyr Phe Asn Leu 
1               5                   


<210>  111
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody

<400>  111

Ala Leu Gly Ser Ser Gly Tyr Arg Val Asn Leu 
1               5                   10      


<210>  112
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody

<400>  112

Asp Pro Gln Tyr Phe Ile Leu 
1               5           


<210>  113
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody

<400>  113

Leu Gln Gly Ala Asn Tyr Tyr Asn Ser Leu Ala Leu 
1               5                   10          


<210>  114
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody

<400>  114

Asp Leu Asn Tyr Pro Asp Thr Ser Asn Leu 
1               5                   10  


<210>  115
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody

<400>  115

Tyr Pro Gly Gly Ser Tyr Tyr Asn Leu 
1               5                   


<210>  116
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody

<400>  116

Val Asp Gly Ser Ser Ser Gly Ser Trp Asp Leu 
1               5                   10      


<210>  117
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody

<400>  117

Ser Thr Gly Ser Val Gly Arg Gly Phe Asn Leu 
1               5                   10      


<210>  118
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody

<400>  118

Phe Arg Asp Asp Tyr Ala Ser Leu Lys Leu 
1               5                   10  


<210>  119
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody

<400>  119

Asn Ser Asn Asp Trp Met Tyr Phe Asn Leu 
1               5                   10  


<210>  120
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody

<400>  120

Gln Ala Ser Glu Ser Ile Ser Asn Tyr Leu Ser 
1               5                   10      


<210>  121
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody

<400>  121

Gln Ala Ser Glu Ser Ile Tyr Ser Asn Leu Ala 
1               5                   10      


<210>  122
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody

<400>  122

Gln Ala Ser Gln Ser Ile Tyr Ile Tyr Leu Ser 
1               5                   10      


<210>  123
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody

<400>  123

Gln Ala Ser Glu Asn Ile Gly Asn Gly Leu Ala 
1               5                   10      


<210>  124
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody

<400>  124

Leu Ala Ser Glu Asp Ile Tyr Ser Gly Ile Ser 
1               5                   10      


<210>  125
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody

<400>  125

Gln Ala Ser Glu Asp Ile Tyr Ser Asn Leu Ala 
1               5                   10      


<210>  126
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody

<400>  126

Gln Ala Ser Glu Asp Ile Tyr Ser Asn Leu Ala 
1               5                   10      


<210>  127
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody

<400>  127

Gln Ala Ser Glu Asp Ile Tyr Ser Asn Leu Ala 
1               5                   10      


<210>  128
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody

<400>  128

Gln Ala Ser Glu Asn Ile Tyr Ser Ser Leu Ala 
1               5                   10      


<210>  129
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody

<400>  129

Gln Ser Ser Gln Ser Val Asp Gly Asn Asn Leu Leu Ser 
1               5                   10              


<210>  130
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody

<400>  130

Gln Ala Ser Gln Ser Ile Tyr Ser Phe Leu Ser 
1               5                   10      


<210>  131
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody

<400>  131

Gln Ala Ser Gln Ser Ile Gly Tyr Tyr Leu Ala 
1               5                   10      


<210>  132
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody

<400>  132

Gln Ala Ser Gln Thr Ile Ser Ile Asn Leu Ala 
1               5                   10      


<210>  133
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody

<400>  133

Gln Ala Ser Gln Asn Ile Tyr Ser Asn Leu Ala 
1               5                   10      


<210>  134
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody

<400>  134

Gln Ala Ser Gln Ser Val Tyr Asn Ser Asn His Leu Ser 
1               5                   10              


<210>  135
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody

<400>  135

Gln Ala Ser Gln Ser Ile Ser Ser Tyr Leu Ser 
1               5                   10      


<210>  136
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody

<400>  136

Gln Ala Ser Glu Ser Ile Ser Ala Asn Tyr Trp Ser 
1               5                   10          


<210>  137
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody

<400>  137

Leu Ala Ser Thr Leu Ala Ser 
1               5           


<210>  138
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody

<400>  138

Ala Ala Ser Leu Leu Ala Ser 
1               5           


<210>  139
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody

<400>  139

Asp Ala Ser Lys Leu Ala Ser 
1               5           


<210>  140
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody

<400>  140

Gly Ala Ser Thr Leu Ala Ser 
1               5           


<210>  141
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody

<400>  141

Ala Ala Ser Asn Leu Glu Ser 
1               5           


<210>  142
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody

<400>  142

Gly Ala Ser Thr Leu Ala Ser 
1               5           


<210>  143
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody

<400>  143

Arg Ala Ser Thr Leu Ala Ser 
1               5           


<210>  144
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody

<400>  144

Asp Ala Ser Thr Leu Ala Ser 
1               5           


<210>  145
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody

<400>  145

Asp Ala Ser Asp Leu Ala Ser 
1               5           


<210>  146
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody

<400>  146

Asp Ala Ser Asn Leu Ala Ser 
1               5           


<210>  147
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody

<400>  147

Ala Ala Ser Asp Leu Glu Ser 
1               5           


<210>  148
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody

<400>  148

Arg Ala Ser Thr Leu Ala Ser 
1               5           


<210>  149
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody

<400>  149

Tyr Ala Ser Thr Leu Ala Ser 
1               5           


<210>  150
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody

<400>  150

Ala Ala Ser Leu Leu Ala Ser 
1               5           


<210>  151
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody

<400>  151

Ser Ala Ser Thr Leu Ala Ser 
1               5           


<210>  152
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody

<400>  152

Gly Ala Ser Asn Leu Ala Ser 
1               5           


<210>  153
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody

<400>  153

Gly Ala Ser Thr Leu Ala Ser 
1               5           


<210>  154
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody

<400>  154

Gln Asn Trp Trp Val Ile Glu His Asn Gly Ala Ala 
1               5                   10          


<210>  155
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody

<400>  155

Gln Ser Ala Ser Tyr Ser Thr Gly Pro Asp Trp Thr 
1               5                   10          


<210>  156
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody

<400>  156

Gln Gln Gly Ala Thr Thr Tyr Asn Val Asp Asn Val 
1               5                   10          


<210>  157
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody

<400>  157

Gln Cys Thr Tyr Trp Asn Pro Asp Tyr Ile Gly Gly Ala 
1               5                   10              


<210>  158
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody

<400>  158

Leu Gly Gly Tyr Ser Tyr Ser Asn Thr Gly Pro Thr 
1               5                   10          


<210>  159
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody

<400>  159

Leu Gly Val Cys Thr Asp Ile Ser Thr Asp Asp Leu Tyr Asn Ala 
1               5                   10                  15  


<210>  160
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody

<400>  160

Leu Gly Val Tyr Thr Tyr Ser Thr Asp Ile His Ala 
1               5                   10          


<210>  161
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody

<400>  161

Leu Gly Val Tyr Thr His Ile Ser Ala Asp Asn Ala 
1               5                   10          


<210>  162
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody

<400>  162

Gln Gln Gly Tyr Tyr Ser Gly Gly Thr Asp Asn Asp Val 
1               5                   10              


<210>  163
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody

<400>  163

Gln Gly Ser Tyr Tyr Ser Ser Ser Trp Tyr Asn Val 
1               5                   10          


<210>  164
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody

<400>  164

Gln Cys Asn Tyr Ile Ile Asp Tyr Gly Ala 
1               5                   10  


<210>  165
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody

<400>  165

Gln Ser Tyr Tyr Asn Ser Asp Ser Asp Ala 
1               5                   10  


<210>  166
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody

<400>  166

Gln Gln Gly Tyr Thr Glu Asp Asn Ile Asp Asn Thr 
1               5                   10          


<210>  167
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody

<400>  167

Gln Gly Ala Val Tyr Ser Gly Asn Thr Glu Trp Ala 
1               5                   10          


<210>  168
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody

<400>  168

Gln Gly Glu Phe Ser Cys Val Ser Ala Asp Cys Ile Ala 
1               5                   10              


<210>  169
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody

<400>  169

Gln Cys Thr Tyr Tyr Asp Asn Asn Tyr Gly Gly Ala 
1               5                   10          


<210>  170
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody

<400>  170

Gln Ser Trp Tyr Tyr Ser Gly Ser Gly Ser Tyr His Ser Trp Ala 
1               5                   10                  15  


<210>  171
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  171

Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
1               5                   10                  15      


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            20                  25                  30          


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        35                  40                  45              


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
    50                  55                  60                  


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
65                  70                  75                  80  


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                85                  90                  95      


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105         


<210>  172
<211>  329
<212>  PRT
<213>  Homo sapiens

<400>  172

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly 
                325                 


<210>  173
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody

<400>  173

Glu Val Gln Leu Leu Glu Ser Gly Gly Arg Leu Val Gln Pro Gly Thr 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Ile Asp Leu Ser Ser Tyr 
            20                  25                  30          


Ala Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Tyr Val 
        35                  40                  45              


Gly Val Ile Thr Ser Ser Ala Thr Thr Tyr Tyr Ala Ser Trp Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Lys Thr Ser Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Phe Cys Ala 
                85                  90                  95      


Arg Gly Gly Pro Gly Tyr Ser Thr Asn Thr His Tyr Ala Phe Asp Pro 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210>  174
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized antibody

<400>  174

Asp Val Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Ser Ile Tyr Ser Phe 
            20                  25                  30          


Leu Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Asp Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Ser Asn Tyr Ile Ile Asp Tyr 
                85                  90                  95      


Gly Ala Phe Gly Gln Gly Thr Lys Val Val Ile Lys 
            100                 105             


<210>  175
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized antibody

<400>  175

Gln Ser Asn Tyr Ile Ile Asp Tyr Gly Ala 
1               5                   10  


