                         SEQUENCE LISTING

<110>  Adverum Biotechnologies, Inc.
       Keravala, Annahita
 
<120>  EVASION OF NEUTRALIZING ANTIBODIES BY A RECOMBINANT 
       ADENO-ASSOCIATED VIRUS

<130>  AVBI-013/01WO 307702-2064

<150>  US 62/330,002
<151>  2016-04-29

<160>  29    

<170>  PatentIn version 3.5

<210>  1
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  7m8 insersertion sequence motif


<220>
<221>  MISC_FEATURE
<222>  (1)..(2)
<223>  Xaa is Ala, Leu, Gly, Ser, Thr or absent

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is Leu, Asn or Lys

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is Gly, Glu, Ala or Asp

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa is Glu, Thr, Gly or Pro

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa is Thr, Ile, Gln or Lys

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa is Thr or Ala

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa is Arg, Asn or Thr

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa is Pro, Asn or absent

<220>
<221>  MISC_FEATURE
<222>  (10)..(11)
<223>  Xaa is Ala, Leu, Gly, Ser, Thr or absent

<400>  1

Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10      


<210>  2
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  7m8 insersertion sequence motif


<220>
<221>  MISC_FEATURE
<222>  (1)..(2)
<223>  Xaa is Ala, Leu, Gly, Ser, Thr or absent

<220>
<221>  MISC_FEATURE
<222>  (3)..(6)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (10)..(11)
<223>  Xaa is Ala, Leu, Gly, Ser, Thr or absent

<400>  2

Xaa Xaa Xaa Xaa Xaa Xaa Thr Arg Pro Xaa Xaa 
1               5                   10      


<210>  3
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  7m8 insersertion sequence motif


<220>
<221>  MISC_FEATURE
<222>  (1)..(2)
<223>  Xaa is Ala, Leu, Gly, Ser, Thr or absent

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is Leu, Asn or absent

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is Gly, Glu or absent

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa is Glu or Thr

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa is Thr or Ile

<220>
<221>  MISC_FEATURE
<222>  (10)..(11)
<223>  Xaa is Ala, Leu, Gly, Ser, Thr or absent

<400>  3

Xaa Xaa Xaa Xaa Xaa Xaa Thr Arg Pro Xaa Xaa 
1               5                   10      


<210>  4
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  7m8 insersertion sequence motif


<220>
<221>  MISC_FEATURE
<222>  (1)..(2)
<223>  Xaa is Ala, Leu, Gly, Ser, Thr or absent

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is Lys or absent

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is Ala or Asp

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa is Gly or Pro

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa is Gln or Lys

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa is Thr or Ala

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa is Asn or Thr

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa is Asn or absent

<220>
<221>  MISC_FEATURE
<222>  (10)..(11)
<223>  Xaa is Ala, Leu, Gly, Ser, Thr or absent

<400>  4

Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10      


<210>  5
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  7m8 insersertion sequence motif


<220>
<221>  MISC_FEATURE
<222>  (1)..(2)
<223>  Xaa is Ala, Leu, Gly, Ser, Thr or absent

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is a positively charged amino acid or an uncharged amino 
       acid; or is selected from Leu, Asn, Arg, Ala, Ser, and Lys; or 
       absent

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is a negatively charged amino acid or an uncharged amino 
       acid; or is selected from Gly, Glu, Ala, Val, Thr, and Asp

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa is a negatively charged amino acid or an uncharged amino 
       acid; or is selected from Glu, Thr, Gly, Asp, or Pro

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa is selected from Thr, Ile, Gly, Lys, Asp, and Gln

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa is a polar amino acid, an alcohol (an amino acid having a 
       free hydroxyl group), or a hydrophobic amino acid; or is selected
       from Thr, Ser, Val, and Ala

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa is a positively charged amino acid or an uncharged amino 
       acid; or is selected from Arg, Val, Lys, Pro, Thr, and Asn

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa is a positively charged amino acid or an uncharged amino 
       acid; or is selected from Pro, Gly, Phe, Asn, and Arg; or is 
       absent

<220>
<221>  MISC_FEATURE
<222>  (10)..(11)
<223>  Xaa is Ala, Leu, Gly, Ser, Thr or absent

<400>  5

Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10      


<210>  6
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized 7m8 insertion peptide

<400>  6

Leu Gly Glu Thr Thr Arg Pro 
1               5           


<210>  7
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized 7m8 insertion peptide

<400>  7

Asn Glu Thr Ile Thr Arg Pro 
1               5           


<210>  8
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized 7m8 insertion peptide

<400>  8

Lys Ala Gly Gln Ala Asn Asn 
1               5           


<210>  9
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized 7m8 insertion peptide

<400>  9

Lys Asp Pro Lys Thr Thr Asn 
1               5           


<210>  10
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized 7m8 insertion peptide

<400>  10

Lys Asp Thr Asp Thr Thr Arg 
1               5           


<210>  11
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized 7m8 insertion peptide

<400>  11

Arg Ala Gly Gly Ser Val Gly 
1               5           


<210>  12
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized 7m8 insertion peptide

<400>  12

Ala Val Asp Thr Thr Lys Phe 
1               5           


<210>  13
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized 7m8 insertion peptide

<400>  13

Ser Thr Gly Lys Val Pro Asn 
1               5           


<210>  14
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized 7m8 insertion peptide

<400>  14

Leu Ala Leu Gly Glu Thr Thr Arg Pro Ala 
1               5                   10  


<210>  15
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized 7m8 insertion peptide

<400>  15

Leu Ala Asn Glu Thr Ile Thr Arg Pro Ala 
1               5                   10  


<210>  16
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized 7m8 insertion peptide

<400>  16

Leu Ala Lys Ala Gly Gln Ala Asn Asn Ala 
1               5                   10  


<210>  17
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized 7m8 insertion peptide

<400>  17

Leu Ala Lys Asp Pro Lys Thr Thr Asn Ala 
1               5                   10  


<210>  18
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized 7m8 insertion peptide

<400>  18

Leu Ala Lys Asp Thr Asp Thr Thr Arg Ala 
1               5                   10  


<210>  19
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized 7m8 insertion peptide

<400>  19

Leu Ala Arg Ala Gly Gly Ser Val Gly Ala 
1               5                   10  


<210>  20
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized 7m8 insertion peptide

<400>  20

Leu Ala Ala Val Asp Thr Thr Lys Phe Ala 
1               5                   10  


<210>  21
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized 7m8 insertion peptide

<400>  21

Leu Ala Ser Thr Gly Lys Val Pro Asn Ala 
1               5                   10  


<210>  22
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized 7m8 insertion peptide

<400>  22

Ala Ala Leu Gly Glu Thr Thr Arg Pro Ala 
1               5                   10  


<210>  23
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized 7m8 insertion peptide

<400>  23

Ala Ala Asn Glu Thr Ile Thr Arg Pro Ala 
1               5                   10  


<210>  24
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized 7m8 insertion peptide

<400>  24

Ala Ala Lys Ala Gly Gln Ala Asn Asn Ala 
1               5                   10  


<210>  25
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized 7m8 insertion peptide

<400>  25

Ala Ala Lys Asp Pro Lys Thr Thr Asn Ala 
1               5                   10  


<210>  26
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized 7m8 insertion peptide

<400>  26

Gly Leu Gly Glu Thr Thr Arg Pro Ala 
1               5                   


<210>  27
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized 7m8 insertion peptide

<400>  27

Gly Asn Glu Thr Ile Thr Arg Pro Ala 
1               5                   


<210>  28
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized 7m8 insertion peptide

<400>  28

Gly Lys Ala Gly Gln Ala Asn Asn Ala 
1               5                   


<210>  29
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized 7m8 insertion peptide

<400>  29

Gly Lys Asp Pro Lys Thr Thr Asn Ala 
1               5                   


