                         SEQUENCE LISTING

<110>  SPARK THERAPEUTICS, INC.
       COUTO, Linda
 
<120>  RELATIVE POTENCY ASSAY FOR VIRAL VECTOR ENCODING ISOMERHYDROLASES

<130>  023637-0452137

<140>  PCT/US2017/030254
<141>  2017-04-28

<150>  62/328,916
<151>  2016-04-28

<160>  1     

<170>  PatentIn version 3.5

<210>  1
<211>  533
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Ser Ile Gln Val Glu His Pro Ala Gly Gly Tyr Lys Lys Leu Phe 
1               5                   10                  15      


Glu Thr Val Glu Glu Leu Ser Ser Pro Leu Thr Ala His Val Thr Gly 
            20                  25                  30          


Arg Ile Pro Leu Trp Leu Thr Gly Ser Leu Leu Arg Cys Gly Pro Gly 
        35                  40                  45              


Leu Phe Glu Val Gly Ser Glu Pro Phe Tyr His Leu Phe Asp Gly Gln 
    50                  55                  60                  


Ala Leu Leu His Lys Phe Asp Phe Lys Glu Gly His Val Thr Tyr His 
65                  70                  75                  80  


Arg Arg Phe Ile Arg Thr Asp Ala Tyr Val Arg Ala Met Thr Glu Lys 
                85                  90                  95      


Arg Ile Val Ile Thr Glu Phe Gly Thr Cys Ala Phe Pro Asp Pro Cys 
            100                 105                 110         


Lys Asn Ile Phe Ser Arg Phe Phe Ser Tyr Phe Arg Gly Val Glu Val 
        115                 120                 125             


Thr Asp Asn Ala Leu Val Asn Val Tyr Pro Val Gly Glu Asp Tyr Tyr 
    130                 135                 140                 


Ala Cys Thr Glu Thr Asn Phe Ile Thr Lys Ile Asn Pro Glu Thr Leu 
145                 150                 155                 160 


Glu Thr Ile Lys Gln Val Asp Leu Cys Asn Tyr Val Ser Val Asn Gly 
                165                 170                 175     


Ala Thr Ala His Pro His Ile Glu Asn Asp Gly Thr Val Tyr Asn Ile 
            180                 185                 190         


Gly Asn Cys Phe Gly Lys Asn Phe Ser Ile Ala Tyr Asn Ile Val Lys 
        195                 200                 205             


Ile Pro Pro Leu Gln Ala Asp Lys Glu Asp Pro Ile Ser Lys Ser Glu 
    210                 215                 220                 


Ile Val Val Gln Phe Pro Cys Ser Asp Arg Phe Lys Pro Ser Tyr Val 
225                 230                 235                 240 


His Ser Phe Gly Leu Thr Pro Asn Tyr Ile Val Phe Val Glu Thr Pro 
                245                 250                 255     


Val Lys Ile Asn Leu Phe Lys Phe Leu Ser Ser Trp Ser Leu Trp Gly 
            260                 265                 270         


Ala Asn Tyr Met Asp Cys Phe Glu Ser Asn Glu Thr Met Gly Val Trp 
        275                 280                 285             


Leu His Ile Ala Asp Lys Lys Arg Lys Lys Tyr Leu Asn Asn Lys Tyr 
    290                 295                 300                 


Arg Thr Ser Pro Phe Asn Leu Phe His His Ile Asn Thr Tyr Glu Asp 
305                 310                 315                 320 


Asn Gly Phe Leu Ile Val Asp Leu Cys Cys Trp Lys Gly Phe Glu Phe 
                325                 330                 335     


Val Tyr Asn Tyr Leu Tyr Leu Ala Asn Leu Arg Glu Asn Trp Glu Glu 
            340                 345                 350         


Val Lys Lys Asn Ala Arg Lys Ala Pro Gln Pro Glu Val Arg Arg Tyr 
        355                 360                 365             


Val Leu Pro Leu Asn Ile Asp Lys Ala Asp Thr Gly Lys Asn Leu Val 
    370                 375                 380                 


Thr Leu Pro Asn Thr Thr Ala Thr Ala Ile Leu Cys Ser Asp Glu Thr 
385                 390                 395                 400 


Ile Trp Leu Glu Pro Glu Val Leu Phe Ser Gly Pro Arg Gln Ala Phe 
                405                 410                 415     


Glu Phe Pro Gln Ile Asn Tyr Gln Lys Tyr Cys Gly Lys Pro Tyr Thr 
            420                 425                 430         


Tyr Ala Tyr Gly Leu Gly Leu Asn His Phe Val Pro Asp Arg Leu Cys 
        435                 440                 445             


Lys Leu Asn Val Lys Thr Lys Glu Thr Trp Val Trp Gln Glu Pro Asp 
    450                 455                 460                 


Ser Tyr Pro Ser Glu Pro Ile Phe Val Ser His Pro Asp Ala Leu Glu 
465                 470                 475                 480 


Glu Asp Asp Gly Val Val Leu Ser Val Val Val Ser Pro Gly Ala Gly 
                485                 490                 495     


Gln Lys Pro Ala Tyr Leu Leu Ile Leu Asn Ala Lys Asp Leu Ser Glu 
            500                 505                 510         


Val Ala Arg Ala Glu Val Glu Ile Asn Ile Pro Val Thr Phe His Gly 
        515                 520                 525             


Leu Phe Lys Lys Ser 
    530             


