                         SEQUENCE LISTING

<110>  Regeneron Pharmaceuticals, Inc.
 
<120>  MULTISPECIFIC ANTIGEN-BINDING MOLECULES AND USES THEREOF

<130>  238811-31.3 (10260WO01)

<150>  62328891
<151>  2016-04-28

<160>  4     

<170>  PatentIn version 3.5

<210>  1
<211>  502
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic

<400>  1

Met Met Ala Leu Gly Ala Ala Gly Ala Thr Arg Val Phe Val Ala Met 
1               5                   10                  15      


Val Ala Ala Ala Leu Gly Gly His Pro Leu Leu Gly Val Ser Ala Thr 
            20                  25                  30          


Leu Asn Ser Val Leu Asn Ser Asn Ala Ile Lys Asn Leu Pro Pro Pro 
        35                  40                  45              


Leu Gly Gly Ala Ala Gly His Pro Gly Ser Ala Val Ser Ala Ala Pro 
    50                  55                  60                  


Gly Ile Leu Tyr Pro Gly Gly Asn Lys Tyr Gln Thr Ile Asp Asn Tyr 
65                  70                  75                  80  


Gln Pro Tyr Pro Cys Ala Glu Asp Glu Glu Cys Gly Thr Asp Glu Tyr 
                85                  90                  95      


Cys Ala Ser Pro Thr Arg Gly Gly Asp Ala Gly Val Gln Ile Cys Leu 
            100                 105                 110         


Ala Cys Arg Lys Arg Arg Lys Arg Cys Met Arg His Ala Met Cys Cys 
        115                 120                 125             


Pro Gly Asn Tyr Cys Lys Asn Gly Ile Cys Val Ser Ser Asp Gln Asn 
    130                 135                 140                 


His Phe Arg Gly Glu Ile Glu Glu Thr Ile Thr Glu Ser Phe Gly Asn 
145                 150                 155                 160 


Asp His Ser Thr Leu Asp Gly Tyr Ser Arg Arg Thr Thr Leu Ser Ser 
                165                 170                 175     


Lys Met Tyr His Thr Lys Gly Gln Glu Gly Ser Val Cys Leu Arg Ser 
            180                 185                 190         


Ser Asp Cys Ala Ser Gly Leu Cys Cys Ala Arg His Phe Trp Ser Lys 
        195                 200                 205             


Ile Cys Lys Pro Val Leu Lys Glu Gly Gln Val Cys Thr Lys His Arg 
    210                 215                 220                 


Arg Lys Gly Ser His Gly Leu Glu Ile Phe Gln Arg Cys Tyr Cys Gly 
225                 230                 235                 240 


Glu Gly Leu Ser Cys Arg Ile Gln Lys Asp His His Gln Ala Ser Asn 
                245                 250                 255     


Ser Ser Arg Leu His Thr Cys Gln Arg His Gly Pro Gly Glu Pro Arg 
            260                 265                 270         


Gly Pro Thr Ile Lys Pro Cys Pro Pro Cys Lys Cys Pro Ala Pro Asn 
        275                 280                 285             


Leu Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Ile Lys Asp 
    290                 295                 300                 


Val Leu Met Ile Ser Leu Ser Pro Ile Val Thr Cys Val Val Val Asp 
305                 310                 315                 320 


Val Ser Glu Asp Asp Pro Asp Val Gln Ile Ser Trp Phe Val Asn Asn 
                325                 330                 335     


Val Glu Val His Thr Ala Gln Thr Gln Thr His Arg Glu Asp Tyr Asn 
            340                 345                 350         


Ser Thr Leu Arg Val Val Ser Ala Leu Pro Ile Gln His Gln Asp Trp 
        355                 360                 365             


Met Ser Gly Lys Glu Phe Lys Cys Lys Val Asn Asn Lys Asp Leu Pro 
    370                 375                 380                 


Ala Pro Ile Glu Arg Thr Ile Ser Lys Pro Lys Gly Ser Val Arg Ala 
385                 390                 395                 400 


Pro Gln Val Tyr Val Leu Pro Pro Pro Glu Glu Glu Met Thr Lys Lys 
                405                 410                 415     


Gln Val Thr Leu Thr Cys Met Val Thr Asp Phe Met Pro Glu Asp Ile 
            420                 425                 430         


Tyr Val Glu Trp Thr Asn Asn Gly Lys Thr Glu Leu Asn Tyr Lys Asn 
        435                 440                 445             


Thr Glu Pro Val Leu Asp Ser Asp Gly Ser Tyr Phe Met Tyr Ser Lys 
    450                 455                 460                 


Leu Arg Val Glu Lys Lys Asn Trp Val Glu Arg Asn Ser Tyr Ser Cys 
465                 470                 475                 480 


Ser Val Val His Glu Gly Leu His Asn His His Thr Thr Lys Ser Phe 
                485                 490                 495     


Ser Arg Thr Pro Gly Lys 
            500         


<210>  2
<211>  496
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic

<400>  2

Met Met Ala Leu Gly Ala Ala Gly Ala Thr Arg Val Phe Val Ala Met 
1               5                   10                  15      


Val Ala Ala Ala Leu Gly Gly His Pro Leu Leu Gly Val Ser Ala Thr 
            20                  25                  30          


Leu Asn Ser Val Leu Asn Ser Asn Ala Ile Lys Asn Leu Pro Pro Pro 
        35                  40                  45              


Leu Gly Gly Ala Ala Gly His Pro Gly Ser Ala Val Ser Ala Ala Pro 
    50                  55                  60                  


Gly Ile Leu Tyr Pro Gly Gly Asn Lys Tyr Gln Thr Ile Asp Asn Tyr 
65                  70                  75                  80  


Gln Pro Tyr Pro Cys Ala Glu Asp Glu Glu Cys Gly Thr Asp Glu Tyr 
                85                  90                  95      


Cys Ala Ser Pro Thr Arg Gly Gly Asp Ala Gly Val Gln Ile Cys Leu 
            100                 105                 110         


Ala Cys Arg Lys Arg Arg Lys Arg Cys Met Arg His Ala Met Cys Cys 
        115                 120                 125             


Pro Gly Asn Tyr Cys Lys Asn Gly Ile Cys Val Ser Ser Asp Gln Asn 
    130                 135                 140                 


His Phe Arg Gly Glu Ile Glu Glu Thr Ile Thr Glu Ser Phe Gly Asn 
145                 150                 155                 160 


Asp His Ser Thr Leu Asp Gly Tyr Ser Arg Arg Thr Thr Leu Ser Ser 
                165                 170                 175     


Lys Met Tyr His Thr Lys Gly Gln Glu Gly Ser Val Cys Leu Arg Ser 
            180                 185                 190         


Ser Asp Cys Ala Ser Gly Leu Cys Cys Ala Arg His Phe Trp Ser Lys 
        195                 200                 205             


Ile Cys Lys Pro Val Leu Lys Glu Gly Gln Val Cys Thr Lys His Arg 
    210                 215                 220                 


Arg Lys Gly Ser His Gly Leu Glu Ile Phe Gln Arg Cys Tyr Cys Gly 
225                 230                 235                 240 


Glu Gly Leu Ser Cys Arg Ile Gln Lys Asp His His Gln Ala Ser Asn 
                245                 250                 255     


Ser Ser Arg Leu His Thr Cys Gln Arg His Gly Pro Gly Asp Lys Thr 
            260                 265                 270         


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
        275                 280                 285             


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
    290                 295                 300                 


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
305                 310                 315                 320 


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
                325                 330                 335     


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
            340                 345                 350         


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
        355                 360                 365             


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
    370                 375                 380                 


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
385                 390                 395                 400 


Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys 
                405                 410                 415     


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
            420                 425                 430         


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
        435                 440                 445             


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
    450                 455                 460                 


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
465                 470                 475                 480 


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                485                 490                 495     


<210>  3
<211>  122
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic

<400>  3

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Trp Tyr Asp Gly Ser Ile Lys Tyr Phe Arg Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Val Glu Asp Thr Ala His Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Glu Ser Ser Ser Trp Tyr Phe Tyr His Gly Leu Asp Val Trp 
            100                 105                 110         


Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120         


<210>  4
<211>  114
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic

<400>  4

Glu Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Ser Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Asn Gln Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Asn Asn Tyr Leu Ala Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro His Leu Leu Ile Tyr Leu Gly Ser Asn Arg Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Gly Asp Val Gly Thr Tyr Phe Cys Met Gln Ser 
                85                  90                  95      


Leu Gln Ala Pro Pro Phe Thr Phe Gly Pro Gly Thr Lys Val Glu Ile 
            100                 105                 110         


Lys Arg 
        


