                         SEQUENCE LISTING

<110>  THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE
       McKinsey, Timothy
       Bagchi, Rushita
       Ferguson, Bradley
       Stratton, Matthew
 
<120>  Compounds and Compositions Useful for Treating Metabolic 
       Syndrome, and Methods Using Same

<130>  205948-7038WO1(00170)

<150>  US 62/329,843
<151>  2016-04-29

<160>  2     

<170>  PatentIn version 3.5

<210>  1
<211>  800
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Leu Gln Asn Val Thr Pro His Asn Lys Leu Pro Gly Glu Gly Asn 
1               5                   10                  15      


Ala Gly Leu Leu Gly Leu Gly Pro Glu Ala Ala Ala Pro Gly Lys Arg 
            20                  25                  30          


Ile Arg Lys Pro Ser Leu Leu Tyr Glu Gly Phe Glu Ser Pro Thr Met 
        35                  40                  45              


Ala Ser Val Pro Ala Leu Gln Leu Thr Pro Ala Asn Pro Pro Pro Pro 
    50                  55                  60                  


Glu Val Ser Asn Pro Lys Lys Pro Gly Arg Val Thr Asn Gln Leu Gln 
65                  70                  75                  80  


Tyr Leu His Lys Val Val Met Lys Ala Leu Trp Lys His Gln Phe Ala 
                85                  90                  95      


Trp Pro Phe Arg Gln Pro Val Asp Ala Val Lys Leu Gly Leu Pro Asp 
            100                 105                 110         


Tyr His Lys Ile Ile Lys Gln Pro Met Asp Met Gly Thr Ile Lys Arg 
        115                 120                 125             


Arg Leu Glu Asn Asn Tyr Tyr Trp Ala Ala Ser Glu Cys Met Gln Asp 
    130                 135                 140                 


Phe Asn Thr Met Phe Thr Asn Cys Tyr Ile Tyr Asn Lys Pro Thr Asp 
145                 150                 155                 160 


Asp Ile Val Leu Met Ala Gln Thr Leu Glu Lys Ile Phe Leu Gln Lys 
                165                 170                 175     


Val Ala Ser Met Pro Gln Glu Glu Gln Glu Leu Val Val Thr Ile Pro 
            180                 185                 190         


Lys Asn Ser His Lys Lys Gly Ala Lys Leu Ala Ala Leu Gln Gly Ser 
        195                 200                 205             


Val Thr Ser Ala His Gln Val Pro Ala Val Ser Ser Val Ser His Thr 
    210                 215                 220                 


Ala Leu Tyr Thr Pro Pro Pro Glu Ile Pro Thr Thr Val Leu Asn Ile 
225                 230                 235                 240 


Pro His Pro Ser Val Ile Ser Ser Pro Leu Leu Lys Ser Leu His Ser 
                245                 250                 255     


Ala Gly Pro Pro Leu Leu Ala Val Thr Ala Ala Pro Pro Ala Gln Pro 
            260                 265                 270         


Leu Ala Lys Lys Lys Gly Val Lys Arg Lys Ala Asp Thr Thr Thr Pro 
        275                 280                 285             


Thr Pro Thr Ala Ile Leu Ala Pro Gly Ser Pro Ala Ser Pro Pro Gly 
    290                 295                 300                 


Ser Leu Glu Pro Lys Ala Ala Arg Leu Pro Pro Met Arg Arg Glu Ser 
305                 310                 315                 320 


Gly Arg Pro Ile Lys Pro Pro Arg Lys Asp Leu Pro Asp Ser Gln Gln 
                325                 330                 335     


Gln His Gln Ser Ser Lys Lys Gly Lys Leu Ser Glu Gln Leu Lys His 
            340                 345                 350         


Cys Asn Gly Ile Leu Lys Glu Leu Leu Ser Lys Lys His Ala Ala Tyr 
        355                 360                 365             


Ala Trp Pro Phe Tyr Lys Pro Val Asp Ala Ser Ala Leu Gly Leu His 
    370                 375                 380                 


Asp Tyr His Asp Ile Ile Lys His Pro Met Asp Leu Ser Thr Val Lys 
385                 390                 395                 400 


Arg Lys Met Glu Asn Arg Asp Tyr Arg Asp Ala Gln Glu Phe Ala Ala 
                405                 410                 415     


Asp Val Arg Leu Met Phe Ser Asn Cys Tyr Lys Tyr Asn Pro Pro Asp 
            420                 425                 430         


His Asp Val Val Ala Met Ala Arg Lys Leu Gln Asp Val Phe Glu Phe 
        435                 440                 445             


Arg Tyr Ala Lys Met Pro Asp Glu Pro Leu Glu Pro Gly Pro Leu Pro 
    450                 455                 460                 


Val Ser Thr Ala Met Pro Pro Gly Leu Ala Lys Ser Ser Ser Glu Ser 
465                 470                 475                 480 


Ser Ser Glu Glu Ser Ser Ser Glu Ser Ser Ser Glu Glu Glu Glu Glu 
                485                 490                 495     


Glu Asp Glu Glu Asp Glu Glu Glu Glu Glu Ser Glu Ser Ser Asp Ser 
            500                 505                 510         


Glu Glu Glu Arg Ala His Arg Leu Ala Glu Leu Gln Glu Gln Leu Arg 
        515                 520                 525             


Ala Val His Glu Gln Leu Ala Ala Leu Ser Gln Gly Pro Ile Ser Lys 
    530                 535                 540                 


Pro Lys Arg Lys Arg Glu Lys Lys Glu Lys Lys Lys Lys Arg Lys Ala 
545                 550                 555                 560 


Glu Lys His Arg Gly Arg Ala Gly Ala Asp Glu Asp Asp Lys Gly Pro 
                565                 570                 575     


Arg Ala Pro Arg Pro Pro Gln Pro Lys Lys Ser Lys Lys Ala Ser Gly 
            580                 585                 590         


Ser Gly Gly Gly Ser Ala Ala Leu Gly Pro Ser Gly Phe Gly Pro Ser 
        595                 600                 605             


Gly Gly Ser Gly Thr Lys Leu Pro Lys Lys Ala Thr Lys Thr Ala Pro 
    610                 615                 620                 


Pro Ala Leu Pro Thr Gly Tyr Asp Ser Glu Glu Glu Glu Glu Ser Arg 
625                 630                 635                 640 


Pro Met Ser Tyr Asp Glu Lys Arg Gln Leu Ser Leu Asp Ile Asn Lys 
                645                 650                 655     


Leu Pro Gly Glu Lys Leu Gly Arg Val Val His Ile Ile Gln Ala Arg 
            660                 665                 670         


Glu Pro Ser Leu Arg Asp Ser Asn Pro Glu Glu Ile Glu Ile Asp Phe 
        675                 680                 685             


Glu Thr Leu Lys Pro Ser Thr Leu Arg Glu Leu Glu Arg Tyr Val Leu 
    690                 695                 700                 


Ser Cys Leu Arg Lys Lys Pro Arg Lys Pro Tyr Thr Ile Lys Lys Pro 
705                 710                 715                 720 


Val Gly Lys Thr Lys Glu Glu Leu Ala Leu Glu Lys Lys Arg Glu Leu 
                725                 730                 735     


Glu Lys Arg Leu Gln Asp Val Ser Gly Gln Leu Asn Ser Thr Lys Lys 
            740                 745                 750         


Pro Pro Lys Lys Ala Asn Glu Lys Thr Glu Ser Ser Ser Ala Gln Gln 
        755                 760                 765             


Val Ala Val Ser Arg Leu Ser Ala Ser Ser Ser Ser Ser Asp Ser Ser 
    770                 775                 780                 


Ser Ser Ser Ser Ser Ser Ser Ser Ser Asp Thr Ser Asp Ser Asp Ser 
785                 790                 795                 800 


<210>  2
<211>  347
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Leu His Thr Thr Gln Leu Tyr Gln His Val Pro Glu Thr Arg Trp 
1               5                   10                  15      


Pro Ile Val Tyr Ser Pro Arg Tyr Asn Ile Thr Phe Met Gly Leu Glu 
            20                  25                  30          


Lys Leu His Pro Phe Asp Ala Gly Lys Trp Gly Lys Val Ile Asn Phe 
        35                  40                  45              


Leu Lys Glu Glu Lys Leu Leu Ser Asp Ser Met Leu Val Glu Ala Arg 
    50                  55                  60                  


Glu Ala Ser Glu Glu Asp Leu Leu Val Val His Thr Arg Arg Tyr Leu 
65                  70                  75                  80  


Asn Glu Leu Lys Trp Ser Phe Ala Val Ala Thr Ile Thr Glu Ile Pro 
                85                  90                  95      


Pro Val Ile Phe Leu Pro Asn Phe Leu Val Gln Arg Lys Val Leu Arg 
            100                 105                 110         


Pro Leu Arg Thr Gln Thr Gly Gly Thr Ile Met Ala Gly Lys Leu Ala 
        115                 120                 125             


Val Glu Arg Gly Trp Ala Ile Asn Val Gly Gly Gly Phe His His Cys 
    130                 135                 140                 


Ser Ser Asp Arg Gly Gly Gly Phe Cys Ala Tyr Ala Asp Ile Thr Leu 
145                 150                 155                 160 


Ala Ile Lys Phe Leu Phe Glu Arg Val Glu Gly Ile Ser Arg Ala Thr 
                165                 170                 175     


Ile Ile Asp Leu Asp Ala His Gln Gly Asn Gly His Glu Arg Asp Phe 
            180                 185                 190         


Met Asp Asp Lys Arg Val Tyr Ile Met Asp Val Tyr Asn Arg His Ile 
        195                 200                 205             


Tyr Pro Gly Asp Arg Phe Ala Lys Gln Ala Ile Arg Arg Lys Val Glu 
    210                 215                 220                 


Leu Glu Trp Gly Thr Glu Asp Asp Glu Tyr Leu Asp Lys Val Glu Arg 
225                 230                 235                 240 


Asn Ile Lys Lys Ser Leu Gln Glu His Leu Pro Asp Val Val Val Tyr 
                245                 250                 255     


Asn Ala Gly Thr Asp Ile Leu Glu Gly Asp Arg Leu Gly Gly Leu Ser 
            260                 265                 270         


Ile Ser Pro Ala Gly Ile Val Lys Arg Asp Glu Leu Val Phe Arg Met 
        275                 280                 285             


Val Arg Gly Arg Arg Val Pro Ile Leu Met Val Thr Ser Gly Gly Tyr 
    290                 295                 300                 


Gln Lys Arg Thr Ala Arg Ile Ile Ala Asp Ser Ile Leu Asn Leu Phe 
305                 310                 315                 320 


Gly Leu Gly Leu Ile Gly Pro Glu Ser Pro Ser Val Ser Ala Gln Asn 
                325                 330                 335     


Ser Asp Thr Pro Leu Leu Pro Pro Ala Val Pro 
            340                 345         


