                         SEQUENCE LISTING

<110>  Pajvani, Utpal B.
       Kim, KyeongJin
 
<120>  FREE RAPTOR REDUCES AGING- AND OBESITY-INDUCED FATTY LIVER

<130>  0575/89275-A-PCT/JPW/GJG/MW

<160>  4     

<170>  PatentIn version 3.5

<210>  1
<211>  1335
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Glu Ser Glu Met Leu Gln Ser Pro Leu Leu Gly Leu Gly Glu Glu 
1               5                   10                  15      


Asp Glu Ala Asp Leu Thr Asp Trp Asn Leu Pro Leu Ala Phe Met Lys 
            20                  25                  30          


Lys Arg His Cys Glu Lys Ile Glu Gly Ser Lys Ser Leu Ala Gln Ser 
        35                  40                  45              


Trp Arg Met Lys Asp Arg Met Lys Thr Val Ser Val Ala Leu Val Leu 
    50                  55                  60                  


Cys Leu Asn Val Gly Val Asp Pro Pro Asp Val Val Lys Thr Thr Pro 
65                  70                  75                  80  


Cys Ala Arg Leu Glu Cys Trp Ile Asp Pro Leu Ser Met Gly Pro Gln 
                85                  90                  95      


Lys Ala Leu Glu Thr Ile Gly Ala Asn Leu Gln Lys Gln Tyr Glu Asn 
            100                 105                 110         


Trp Gln Pro Arg Ala Arg Tyr Lys Gln Ser Leu Asp Pro Thr Val Asp 
        115                 120                 125             


Glu Val Lys Lys Leu Cys Thr Ser Leu Arg Arg Asn Ala Lys Glu Glu 
    130                 135                 140                 


Arg Val Leu Phe His Tyr Asn Gly His Gly Val Pro Arg Pro Thr Val 
145                 150                 155                 160 


Asn Gly Glu Val Trp Val Phe Asn Lys Asn Tyr Thr Gln Tyr Ile Pro 
                165                 170                 175     


Leu Ser Ile Tyr Asp Leu Gln Thr Trp Met Gly Ser Pro Ser Ile Phe 
            180                 185                 190         


Val Tyr Asp Cys Ser Asn Ala Gly Leu Ile Val Lys Ser Phe Lys Gln 
        195                 200                 205             


Phe Ala Leu Gln Arg Glu Gln Glu Leu Glu Val Ala Ala Ile Asn Pro 
    210                 215                 220                 


Asn His Pro Leu Ala Gln Met Pro Leu Pro Pro Ser Met Lys Asn Cys 
225                 230                 235                 240 


Ile Gln Leu Ala Ala Cys Glu Ala Thr Glu Leu Leu Pro Met Ile Pro 
                245                 250                 255     


Asp Leu Pro Ala Asp Leu Phe Thr Ser Cys Leu Thr Thr Pro Ile Lys 
            260                 265                 270         


Ile Ala Leu Arg Trp Phe Cys Met Gln Lys Cys Val Ser Leu Val Pro 
        275                 280                 285             


Gly Val Thr Leu Asp Leu Ile Glu Lys Ile Pro Gly Arg Leu Asn Asp 
    290                 295                 300                 


Arg Arg Thr Pro Leu Gly Glu Leu Asn Trp Ile Phe Thr Ala Ile Thr 
305                 310                 315                 320 


Asp Thr Ile Ala Trp Asn Val Leu Pro Arg Asp Leu Phe Gln Lys Leu 
                325                 330                 335     


Phe Arg Gln Asp Leu Leu Val Ala Ser Leu Phe Arg Asn Phe Leu Leu 
            340                 345                 350         


Ala Glu Arg Ile Met Arg Ser Tyr Asn Cys Thr Pro Val Ser Ser Pro 
        355                 360                 365             


Arg Leu Pro Pro Thr Tyr Met His Ala Met Trp Gln Ala Trp Asp Leu 
    370                 375                 380                 


Ala Val Asp Ile Cys Leu Ser Gln Leu Pro Thr Ile Ile Glu Glu Gly 
385                 390                 395                 400 


Thr Ala Phe Arg His Ser Pro Phe Phe Ala Glu Gln Leu Thr Ala Phe 
                405                 410                 415     


Gln Val Trp Leu Thr Met Gly Val Glu Asn Arg Asn Pro Pro Glu Gln 
            420                 425                 430         


Leu Pro Ile Val Leu Gln Val Leu Leu Ser Gln Val His Arg Leu Arg 
        435                 440                 445             


Ala Leu Asp Leu Leu Gly Arg Phe Leu Asp Leu Gly Pro Trp Ala Val 
    450                 455                 460                 


Ser Leu Ala Leu Ser Val Gly Ile Phe Pro Tyr Val Leu Lys Leu Leu 
465                 470                 475                 480 


Gln Ser Ser Ala Arg Glu Leu Arg Pro Leu Leu Val Phe Ile Trp Ala 
                485                 490                 495     


Lys Ile Leu Ala Val Asp Ser Ser Cys Gln Ala Asp Leu Val Lys Asp 
            500                 505                 510         


Asn Gly His Lys Tyr Phe Leu Ser Val Leu Ala Asp Pro Tyr Met Pro 
        515                 520                 525             


Ala Glu His Arg Thr Met Thr Ala Phe Ile Leu Ala Val Ile Val Asn 
    530                 535                 540                 


Ser Tyr His Thr Gly Gln Glu Ala Cys Leu Gln Gly Asn Leu Ile Ala 
545                 550                 555                 560 


Ile Cys Leu Glu Gln Leu Asn Asp Pro His Pro Leu Leu Arg Gln Trp 
                565                 570                 575     


Val Ala Ile Cys Leu Gly Arg Ile Trp Gln Asn Phe Asp Ser Ala Arg 
            580                 585                 590         


Trp Cys Gly Val Arg Asp Ser Ala His Glu Lys Leu Tyr Ser Leu Leu 
        595                 600                 605             


Ser Asp Pro Ile Pro Glu Val Arg Cys Ala Ala Val Phe Ala Leu Gly 
    610                 615                 620                 


Thr Phe Val Gly Asn Ser Ala Glu Arg Thr Asp His Ser Thr Thr Ile 
625                 630                 635                 640 


Asp His Asn Val Ala Met Met Leu Ala Gln Leu Val Ser Asp Gly Ser 
                645                 650                 655     


Pro Met Val Arg Lys Glu Leu Val Val Ala Leu Ser His Leu Val Val 
            660                 665                 670         


Gln Tyr Glu Ser Asn Phe Cys Thr Val Ala Leu Gln Phe Ile Glu Glu 
        675                 680                 685             


Glu Lys Asn Tyr Ala Leu Pro Ser Pro Ala Thr Thr Glu Gly Gly Ser 
    690                 695                 700                 


Leu Thr Pro Val Arg Asp Ser Pro Cys Thr Pro Arg Leu Arg Ser Val 
705                 710                 715                 720 


Ser Ser Tyr Gly Asn Ile Arg Ala Val Ala Thr Ala Arg Ser Leu Asn 
                725                 730                 735     


Lys Ser Leu Gln Asn Leu Ser Leu Thr Glu Glu Ser Gly Gly Ala Val 
            740                 745                 750         


Ala Phe Ser Pro Gly Asn Leu Ser Thr Ser Ser Ser Ala Ser Ser Thr 
        755                 760                 765             


Leu Gly Ser Pro Glu Asn Glu Glu His Ile Leu Ser Phe Glu Thr Ile 
    770                 775                 780                 


Asp Lys Met Arg Arg Ala Ser Ser Tyr Ser Ser Leu Asn Ser Leu Ile 
785                 790                 795                 800 


Gly Val Ser Phe Asn Ser Val Tyr Thr Gln Ile Trp Arg Val Leu Leu 
                805                 810                 815     


His Leu Ala Ala Asp Pro Tyr Pro Glu Val Ser Asp Val Ala Met Lys 
            820                 825                 830         


Val Leu Asn Ser Ile Ala Tyr Lys Ala Thr Val Asn Ala Arg Pro Gln 
        835                 840                 845             


Arg Val Leu Asp Thr Ser Ser Leu Thr Gln Ser Ala Pro Ala Ser Pro 
    850                 855                 860                 


Thr Asn Lys Gly Val His Ile His Gln Ala Gly Gly Ser Pro Pro Ala 
865                 870                 875                 880 


Ser Ser Thr Ser Ser Ser Ser Leu Thr Asn Asp Val Ala Lys Gln Pro 
                885                 890                 895     


Val Ser Arg Asp Leu Pro Ser Gly Arg Pro Gly Thr Thr Gly Pro Ala 
            900                 905                 910         


Gly Ala Gln Tyr Thr Pro His Ser His Gln Phe Pro Arg Thr Arg Lys 
        915                 920                 925             


Met Phe Asp Lys Gly Pro Glu Gln Thr Ala Asp Asp Ala Asp Asp Ala 
    930                 935                 940                 


Ala Gly His Lys Ser Phe Ile Ser Ala Thr Val Gln Thr Gly Phe Cys 
945                 950                 955                 960 


Asp Trp Ser Ala Arg Tyr Phe Ala Gln Pro Val Met Lys Ile Pro Glu 
                965                 970                 975     


Glu His Asp Leu Glu Ser Gln Ile Arg Lys Glu Arg Glu Trp Arg Phe 
            980                 985                 990         


Leu Arg Asn Ser Arg Val Arg Arg  Gln Ala Gln Gln Val  Ile Gln Lys 
        995                 1000                 1005             


Gly Ile  Thr Arg Leu Asp Asp  Gln Ile Phe Leu Asn  Arg Asn Pro 
    1010                 1015                 1020             


Gly Val  Pro Ser Val Val Lys  Phe His Pro Phe Thr  Pro Cys Ile 
    1025                 1030                 1035             


Ala Val  Ala Asp Lys Asp Ser  Ile Cys Phe Trp Asp  Trp Glu Lys 
    1040                 1045                 1050             


Gly Glu  Lys Leu Asp Tyr Phe  His Asn Gly Asn Pro  Arg Tyr Thr 
    1055                 1060                 1065             


Arg Val  Thr Ala Met Glu Tyr  Leu Asn Gly Gln Asp  Cys Ser Leu 
    1070                 1075                 1080             


Leu Leu  Thr Ala Thr Asp Asp  Gly Ala Ile Arg Val  Trp Lys Asn 
    1085                 1090                 1095             


Phe Ala  Asp Leu Glu Lys Asn  Pro Glu Met Val Thr  Ala Trp Gln 
    1100                 1105                 1110             


Gly Leu  Ser Asp Met Leu Pro  Thr Thr Arg Gly Ala  Gly Met Val 
    1115                 1120                 1125             


Val Asp  Trp Glu Gln Glu Thr  Gly Leu Leu Met Ser  Ser Gly Asp 
    1130                 1135                 1140             


Val Arg  Ile Val Arg Ile Trp  Asp Thr Asp Arg Glu  Met Lys Val 
    1145                 1150                 1155             


Gln Asp  Ile Pro Thr Gly Ala  Asp Ser Cys Val Thr  Ser Leu Ser 
    1160                 1165                 1170             


Cys Asp  Ser His Arg Ser Leu  Ile Val Ala Gly Leu  Gly Asp Gly 
    1175                 1180                 1185             


Ser Ile  Arg Val Tyr Asp Arg  Arg Met Ala Leu Ser  Glu Cys Arg 
    1190                 1195                 1200             


Val Met  Thr Tyr Arg Glu His  Thr Ala Trp Val Val  Lys Ala Ser 
    1205                 1210                 1215             


Leu Gln  Lys Arg Pro Asp Gly  His Ile Val Ser Val  Ser Val Asn 
    1220                 1225                 1230             


Gly Asp  Val Arg Ile Phe Asp  Pro Arg Met Pro Glu  Ser Val Asn 
    1235                 1240                 1245             


Val Leu  Gln Ile Val Lys Gly  Leu Thr Ala Leu Asp  Ile His Pro 
    1250                 1255                 1260             


Gln Ala  Asp Leu Ile Ala Cys  Gly Ser Val Asn Gln  Phe Thr Ala 
    1265                 1270                 1275             


Ile Tyr  Asn Ser Ser Gly Glu  Leu Ile Asn Asn Ile  Lys Tyr Tyr 
    1280                 1285                 1290             


Asp Gly  Phe Met Gly Gln Arg  Val Gly Ala Ile Ser  Cys Leu Ala 
    1295                 1300                 1305             


Phe His  Pro His Trp Pro His  Leu Ala Val Gly Ser  Asn Asp Tyr 
    1310                 1315                 1320             


Tyr Ile  Ser Val Tyr Ser Val  Glu Lys Arg Val Arg  
    1325                 1330                 1335 


<210>  2
<211>  1323
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Lys Arg Asn Gly Ser Arg Asn Cys Leu Asn Arg Arg Ser Arg Phe 
1               5                   10                  15      


Gly Ser Arg Glu Arg Asp Trp Leu Arg Glu Asp Val Lys Arg Gly Cys 
            20                  25                  30          


Val Tyr Leu Tyr Gly Ala Asp Thr Thr Thr Ala Thr Thr Thr Thr Thr 
        35                  40                  45              


Thr Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Asp Leu His Leu 
    50                  55                  60                  


Val Leu Cys Thr Val Glu Thr Pro Ala Ser Glu Ile Cys Ala Gly Glu 
65                  70                  75                  80  


Gly Arg Glu Ser Leu Tyr Leu Gln Leu His Gly Asp Leu Val Arg Arg 
                85                  90                  95      


Leu Glu Pro Thr Glu Arg Pro Leu Gln Ile Val Tyr Asp Tyr Leu Ser 
            100                 105                 110         


Arg Leu Gly Phe Asp Asp Pro Val Arg Ile Gln Glu Glu Ala Thr Asn 
        115                 120                 125             


Pro Asp Leu Gly Cys Met Ile Arg Phe Tyr Gly Glu Lys Pro Cys His 
    130                 135                 140                 


Met Asp Arg Leu Asp Arg Ile Leu Leu Ser Gly Ile Tyr Asn Val Arg 
145                 150                 155                 160 


Lys Gly Lys Thr Gln Leu His Lys Trp Ala Glu Arg Leu Val Val Leu 
                165                 170                 175     


Cys Gly Thr Cys Leu Ile Val Ser Ser Val Lys Asp Cys Gln Thr Gly 
            180                 185                 190         


Lys Met His Ile Leu Pro Leu Val Gly Gly Lys Ile Glu Glu Val Lys 
        195                 200                 205             


Arg Arg Gln Tyr Ser Leu Ala Phe Ser Ser Ala Gly Ala Gln Ala Gln 
    210                 215                 220                 


Thr Tyr His Val Ser Phe Glu Thr Leu Ala Glu Tyr Gln Arg Trp Gln 
225                 230                 235                 240 


Arg Gln Ala Ser Lys Val Val Ser Gln Arg Ile Ser Thr Val Asp Leu 
                245                 250                 255     


Ser Cys Tyr Ser Leu Glu Glu Val Pro Glu His Leu Phe Tyr Ser Gln 
            260                 265                 270         


Asp Ile Thr Tyr Leu Asn Leu Arg His Asn Phe Met Gln Leu Glu Arg 
        275                 280                 285             


Pro Gly Gly Leu Asp Thr Leu Tyr Lys Phe Ser Gln Leu Lys Gly Leu 
    290                 295                 300                 


Asn Leu Ser His Asn Lys Leu Gly Leu Phe Pro Ile Leu Leu Cys Glu 
305                 310                 315                 320 


Ile Ser Thr Leu Thr Glu Leu Asn Leu Ser Cys Asn Gly Phe His Asp 
                325                 330                 335     


Leu Pro Ser Gln Ile Gly Asn Leu Leu Asn Leu Gln Thr Leu Cys Leu 
            340                 345                 350         


Asp Gly Asn Phe Leu Thr Thr Leu Pro Glu Glu Leu Gly Asn Leu Gln 
        355                 360                 365             


Gln Leu Ser Ser Leu Gly Ile Ser Phe Asn Asn Phe Ser Gln Ile Pro 
    370                 375                 380                 


Glu Val Tyr Glu Lys Leu Thr Met Leu Asp Arg Val Val Met Ala Gly 
385                 390                 395                 400 


Asn Cys Leu Glu Val Leu Asn Leu Gly Val Leu Asn Arg Met Asn His 
                405                 410                 415     


Ile Lys His Val Asp Leu Arg Met Asn His Leu Lys Thr Met Val Ile 
            420                 425                 430         


Glu Asn Leu Glu Gly Asn Lys His Ile Thr His Val Asp Leu Arg Asp 
        435                 440                 445             


Asn Arg Leu Thr Asp Leu Asp Leu Ser Ser Leu Cys Ser Leu Glu Gln 
    450                 455                 460                 


Leu His Cys Gly Arg Asn Gln Leu Arg Glu Leu Thr Leu Ser Gly Phe 
465                 470                 475                 480 


Ser Leu Arg Thr Leu Tyr Ala Ser Ser Asn Arg Leu Thr Ala Val Asn 
                485                 490                 495     


Val Tyr Pro Val Pro Ser Leu Leu Thr Phe Leu Asp Leu Ser Arg Asn 
            500                 505                 510         


Leu Leu Glu Cys Val Pro Asp Trp Ala Cys Glu Ala Lys Lys Ile Glu 
        515                 520                 525             


Val Leu Asp Val Ser Tyr Asn Leu Leu Thr Glu Val Pro Val Arg Ile 
    530                 535                 540                 


Leu Ser Ser Leu Ser Leu Arg Lys Leu Met Leu Gly His Asn His Val 
545                 550                 555                 560 


Gln Asn Leu Pro Thr Leu Val Glu His Ile Pro Leu Glu Val Leu Asp 
                565                 570                 575     


Leu Gln His Asn Ala Leu Thr Arg Leu Pro Asp Thr Leu Phe Ser Lys 
            580                 585                 590         


Ala Leu Asn Leu Arg Tyr Leu Asn Ala Ser Ala Asn Ser Leu Glu Ser 
        595                 600                 605             


Leu Pro Ser Ala Cys Thr Gly Glu Glu Ser Leu Ser Met Leu Gln Leu 
    610                 615                 620                 


Leu Tyr Leu Thr Asn Asn Leu Leu Thr Asp Gln Cys Ile Pro Val Leu 
625                 630                 635                 640 


Val Gly His Leu His Leu Arg Ile Leu His Leu Ala Asn Asn Gln Leu 
                645                 650                 655     


Gln Thr Phe Pro Ala Ser Lys Leu Asn Lys Leu Glu Gln Leu Glu Glu 
            660                 665                 670         


Leu Asn Leu Ser Gly Asn Lys Leu Lys Thr Ile Pro Thr Thr Ile Ala 
        675                 680                 685             


Asn Cys Lys Arg Leu His Thr Leu Val Ala His Ser Asn Asn Ile Ser 
    690                 695                 700                 


Ile Phe Pro Glu Ile Leu Gln Leu Pro Gln Ile Gln Phe Val Asp Leu 
705                 710                 715                 720 


Ser Cys Asn Asp Leu Thr Glu Ile Leu Ile Pro Glu Ala Leu Pro Ala 
                725                 730                 735     


Thr Leu Gln Asp Leu Asp Leu Thr Gly Asn Thr Asn Leu Val Leu Glu 
            740                 745                 750         


His Lys Thr Leu Asp Ile Phe Ser His Ile Thr Thr Leu Lys Ile Asp 
        755                 760                 765             


Gln Lys Pro Leu Pro Thr Thr Asp Ser Thr Val Thr Ser Thr Phe Trp 
    770                 775                 780                 


Ser His Gly Leu Ala Glu Met Ala Gly Gln Arg Asn Lys Leu Cys Val 
785                 790                 795                 800 


Ser Ala Leu Ala Met Asp Ser Phe Ala Glu Gly Val Gly Ala Val Tyr 
                805                 810                 815     


Gly Met Phe Asp Gly Asp Arg Asn Glu Glu Leu Pro Arg Leu Leu Gln 
            820                 825                 830         


Cys Thr Met Ala Asp Val Leu Leu Glu Glu Val Gln Gln Ser Thr Asn 
        835                 840                 845             


Asp Thr Val Phe Met Ala Asn Thr Phe Leu Val Ser His Arg Lys Leu 
    850                 855                 860                 


Gly Met Ala Gly Gln Lys Leu Gly Ser Ser Ala Leu Leu Cys Tyr Ile 
865                 870                 875                 880 


Arg Pro Asp Thr Ala Asp Pro Ala Ser Ser Phe Ser Leu Thr Val Ala 
                885                 890                 895     


Asn Val Gly Thr Cys Gln Ala Val Leu Cys Arg Gly Gly Lys Pro Val 
            900                 905                 910         


Pro Leu Ser Lys Val Phe Ser Leu Glu Gln Asp Pro Glu Glu Ala Gln 
        915                 920                 925             


Arg Val Lys Asp Gln Lys Ala Ile Ile Thr Glu Asp Asn Lys Val Asn 
    930                 935                 940                 


Gly Val Thr Cys Cys Thr Arg Met Leu Gly Cys Thr Tyr Leu Tyr Pro 
945                 950                 955                 960 


Trp Ile Leu Pro Lys Pro His Ile Ser Ser Thr Pro Leu Thr Ile Gln 
                965                 970                 975     


Asp Glu Leu Leu Ile Leu Gly Asn Lys Ala Leu Trp Glu His Leu Ser 
            980                 985                 990         


Tyr Thr Glu Ala Val Asn Ala Val  Arg His Val Gln Asp  Pro Leu Ala 
        995                 1000                 1005             


Ala Ala  Lys Lys Leu Cys Thr  Leu Ala Gln Ser Tyr  Gly Cys Gln 
    1010                 1015                 1020             


Asp Asn  Val Gly Ala Met Val  Val Tyr Leu Asn Ile  Gly Glu Glu 
    1025                 1030                 1035             


Gly Cys  Thr Cys Glu Met Asn  Gly Leu Thr Leu Pro  Gly Pro Val 
    1040                 1045                 1050             


Gly Phe  Ala Ser Thr Thr Thr  Ile Lys Asp Ala Pro  Lys Pro Ala 
    1055                 1060                 1065             


Thr Pro  Ser Ser Ser Ser Gly  Ile Ala Ser Glu Phe  Ser Ser Glu 
    1070                 1075                 1080             


Met Ser  Thr Ser Glu Val Ser  Ser Glu Val Gly Ser  Thr Ala Ser 
    1085                 1090                 1095             


Asp Glu  His Asn Ala Gly Gly  Leu Asp Thr Ala Leu  Leu Pro Arg 
    1100                 1105                 1110             


Pro Glu  Arg Arg Cys Ser Leu  His Pro Thr Pro Thr  Ser Gly Leu 
    1115                 1120                 1125             


Phe Gln  Arg Gln Pro Ser Ser  Ala Thr Phe Ser Ser  Asn Gln Ser 
    1130                 1135                 1140             


Asp Asn  Gly Leu Asp Ser Asp  Asp Asp Gln Pro Val  Glu Gly Val 
    1145                 1150                 1155             


Ile Thr  Asn Gly Ser Lys Val  Glu Val Glu Val Asp  Ile His Cys 
    1160                 1165                 1170             


Cys Arg  Gly Arg Asp Leu Glu  Asn Ser Pro Pro Leu  Ile Glu Ser 
    1175                 1180                 1185             


Ser Pro  Thr Leu Cys Ser Glu  Glu His Ala Arg Gly  Ser Cys Phe 
    1190                 1195                 1200             


Gly Ile  Arg Arg Gln Asn Ser  Val Asn Ser Gly Met  Leu Leu Pro 
    1205                 1210                 1215             


Met Ser  Lys Asp Arg Met Glu  Leu Gln Lys Ser Pro  Ser Thr Ser 
    1220                 1225                 1230             


Cys Leu  Tyr Gly Lys Lys Leu  Ser Asn Gly Ser Ile  Val Pro Leu 
    1235                 1240                 1245             


Glu Asp  Ser Leu Asn Leu Ile  Glu Val Ala Thr Glu  Val Pro Lys 
    1250                 1255                 1260             


Arg Lys  Thr Gly Tyr Phe Ala  Ala Pro Thr Gln Met  Glu Pro Glu 
    1265                 1270                 1275             


Asp Gln  Phe Val Val Pro His  Asp Leu Glu Glu Glu  Val Lys Glu 
    1280                 1285                 1290             


Gln Met  Lys Gln His Gln Asp  Ser Arg Leu Glu Pro  Glu Pro His 
    1295                 1300                 1305             


Glu Glu  Asp Arg Thr Glu Pro  Pro Glu Glu Phe Asp  Thr Ala Leu 
    1310                 1315                 1320             


<210>  3
<211>  1294
<212>  DNA
<213>  Homo sapiens

<400>  3
gcatagaatg cagatgagca aagtgagtgg gagagggaag tcatttgtaa caaaaactca       60

ttatttacag atgagaaatt tatattgtca gcgtaatatc tgtgaggcta aacagagctg      120

gagagtatat aaaagcagtg cgccttggtg cagaagtaca gagcttagga cacagagcac      180

atcaaaagtt cccaaagagg gcttgctctc tcttcacctg ctctgttcta cagcacacta      240

ccagaagaca gcagaaatga aaagcattta ctttgtggct ggattatttg taatgctggt      300

acaaggcagc tggcaacgtt cccttcaaga cacagaggag aaatccagat cattctcagc      360

ttcccaggca gacccactca gtgatcctga tcagatgaac gaggacaagc gccattcaca      420

gggcacattc accagtgact acagcaagta tctggactcc aggcgtgccc aagattttgt      480

gcagtggttg atgaatacca agaggaacag gaataacatt gccaaacgtc acgatgaatt      540

tgagagacat gctgaaggga cctttaccag tgatgtaagt tcttatttgg aaggccaagc      600

tgccaaggaa ttcattgctt ggctggtgaa aggccgagga aggcgagatt tcccagaaga      660

ggtcgccatt gttgaagaac ttggccgcag acatgctgat ggttctttct ctgatgagat      720

gaacaccatt cttgataatc ttgccgccag ggactttata aactggttga ttcagaccaa      780

aatcactgac aggaaataac tatatcacta ttcaagatca tcttcacaac atcacctgct      840

agccacgtgg gatgtttgaa atgttaagtc ctgtaaattt aagaggtgta ttctgaggcc      900

acattgcttt gcatgccaat aaataaattt tcttttagtg ttgtgtagcc aaaaattaca      960

aatggaataa agttttatca aaatattgct aaaatatcag ctttaaaata tgaaagtgct     1020

agattctgtt attttcttct tattttggat gaagtacccc aacctgttta catttagcga     1080

taaaattatt tttctatgat ataatttgta aatgtaaatt attccgatct gacatatctg     1140

cattataata ataggagaat agaagaactg gtagccacag tggtgaaatt ggaaagagaa     1200

ctttcttcct gaaacctttg tcttaaaaat actcagcttt caatgtatca aagatacaat     1260

taaataaaat tttcaagctt ctttaccatt gtct                                 1294


<210>  4
<211>  2034
<212>  DNA
<213>  Homo sapiens

<400>  4
ggatctggca gcgccgcgaa gacgagcggt caccggcgcc cgacccgagc gcgcccagag       60

gacggcgggg agccaagccg acccccgagc agcgccgcgc gggccctgag gctcaaaggg      120

gcagcttcag gggaggacac cccactggcc aggacgcccc aggctctgct gctctgccac      180

tcagctgccc tcggaggagc gtacacacac accaggactg cattgcccca gtgtgcagcc      240

cctgccagat gtgggaggca gctagctgcc cagaggcatg cccccctgcc agccacagcg      300

acccctgctg ctgttgctgc tgctgctggc ctgccagcca caggtcccct ccgctcaggt      360

gatggacttc ctgtttgaga agtggaagct ctacggtgac cagtgtcacc acaacctgag      420

cctgctgccc cctcccacgg agctggtgtg caacagaacc ttcgacaagt attcctgctg      480

gccggacacc cccgccaata ccacggccaa catctcctgc ccctggtacc tgccttggca      540

ccacaaagtg caacaccgct tcgtgttcaa gagatgcggg cccgacggtc agtgggtgcg      600

tggaccccgg gggcagcctt ggcgtgatgc ctcccagtgc cagatggatg gcgaggagat      660

tgaggtccag aaggaggtgg ccaagatgta cagcagcttc caggtgatgt acacagtggg      720

ctacagcctg tccctggggg ccctgctcct cgccttggcc atcctggggg gcctcagcaa      780

gctgcactgc acccgcaatg ccatccacgc gaatctgttt gcgtccttcg tgctgaaagc      840

cagctccgtg ctggtcattg atgggctgct caggacccgc tacagccaga aaattggcga      900

cgacctcagt gtcagcacct ggctcagtga tggagcggtg gctggctgcc gtgtggccgc      960

ggtgttcatg caatatggca tcgtggccaa ctactgctgg ctgctggtgg agggcctgta     1020

cctgcacaac ctgctgggcc tggccaccct ccccgagagg agcttcttca gcctctacct     1080

gggcatcggc tggggtgccc ccatgctgtt cgtcgtcccc tgggcagtgg tcaagtgtct     1140

gttcgagaac gtccagtgct ggaccagcaa tgacaacatg ggcttctggt ggatcctgcg     1200

gttccccgtc ttcctggcca tcctgatcaa cttcttcatc ttcgtccgca tcgttcagct     1260

gctcgtggcc aagctgcggg cacggcagat gcaccacaca gactacaagt tccggctggc     1320

caagtccacg ctgaccctca tccctctgct gggcgtccac gaagtggtct ttgccttcgt     1380

gacggacgag cacgcccagg gcaccctgcg ctccgccaag ctcttcttcg acctcttcct     1440

cagctccttc cagggcctgc tggtggctgt cctctactgc ttcctcaaca aggaggtgca     1500

gtcggagctg cggcggcgtt ggcaccgctg gcgcctgggc aaagtgctat gggaggagcg     1560

gaacaccagc aaccacaggg cctcatcttc gcccggccac ggccctccca gcaaggagct     1620

gcagtttggg aggggtggtg gcagccagga ttcatctgcg gagaccccct tggctggtgg     1680

cctccctaga ttggctgaga gccccttctg aaccctgctg ggaccccagc tagggctgga     1740

ctctggcacc cagaggcgtc gctggacaac ccagaactgg acgcccagct gaggctgggg     1800

gcgggggagc caacagcagc ccccacctac cccccacccc cagtgtggct gtctgcgaga     1860

ttgggcctcc tctccctgca cctgccttgt ccctggtgca gaggtgagca gaggagtcca     1920

gggcgggagt gggggctgtg ccgtgaactg cgtgccagtg tccccacgta tgtcggcacg     1980

tcccatgtgc atggaaatgt cctccaacaa taaagagctc aagtggtcac cgtg           2034


