                         SEQUENCE LISTING

<110>  UNIVERSITY OF UTAH RESEARCH FOUNDATION
 
<120>  TARGET-BINDING ACTIVATED SPLIT REPORTER SYSTEMS FOR ANALYTE 
       DETECTION AND RELATED COMPONENTS AND METHODS

<130>  42650/631

<160>  96    

<170>  PatentIn version 3.5

<210>  1
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  1

Val Ser Gly Trp Arg Leu Phe Lys Lys Ile Ser 
1               5                   10      


<210>  2
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  2

Gly Ser Met Leu Phe Arg Val Thr Ile Asn Ser 
1               5                   10      


<210>  3
<211>  148
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  3

Met Val Phe Thr Leu Glu Asp Phe Val Gly Asp Trp Glu Gln Thr Ala 
1               5                   10                  15      


Ala Tyr Asn Leu Asp Gln Val Leu Glu Gln Gly Gly Val Ser Ser Leu 
            20                  25                  30          


Leu Gln Asn Leu Ala Val Ser Val Thr Pro Ile Gln Arg Ile Val Arg 
        35                  40                  45              


Ser Gly Glu Asn Ala Leu Lys Ile Asp Ile His Val Ile Ile Pro Tyr 
    50                  55                  60                  


Glu Gly Leu Ser Ala Asp Gln Met Ala Gln Ile Glu Glu Val Phe Lys 
65                  70                  75                  80  


Val Val Tyr Pro Val Asp Asp His His Phe Lys Val Ile Leu Pro Tyr 
                85                  90                  95      


Gly Thr Leu Val Ile Asp Gly Val Thr Pro Asn Met Leu Asn Tyr Phe 
            100                 105                 110         


Gly Arg Pro Tyr Glu Gly Ile Ala Val Phe Asp Gly Lys Lys Ile Thr 
        115                 120                 125             


Val Thr Gly Thr Leu Trp Asn Gly Asn Lys Ile Ile Asp Glu Arg Leu 
    130                 135                 140                 


Ile Thr Pro Asp 
145             


<210>  4
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  4

Gly Gly Gly Ser Gly His His His His His His His His Gly Gly Gly 
1               5                   10                  15      


Ser Gly 
        


<210>  5
<211>  1549
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  beta-9-L73J (light chain) nucleotide sequence

<400>  5
atgggtagta tgctgtttcg tgttaccatt aacagcggtg gtggtagcgg tcatcatcac       60

caccatcacc atcatggtgg tggcagtggt atggcaagcg atattcagat gacccagagc      120

ccgagcagcc tgagcgcaag cgttggtgat cgtgttacca ttacctgtcg tgcaagccag      180

agcgttagca gcgcggttgc atggtatcag cagaaaccgg gtaaagcacc gaaactgctg      240

atttatagcg caagcagcct gtatagcggt gttccgagcc gttttagcgg tagccgtagc      300

ggcaccgatt ttaccctgac cattagcagc ctgcagccgg aagattttgc aacctattat      360

tgtcagcagg gctattatta cccgtttacc tttggtcagg gcaccaaagt tgaaattaaa      420

cgtaccgttg cagcaccgag cgtttttatc tttccgccta gcgatagcca gctgaaaagc      480

ggtacagcca gcgttgtttg tctgctgaat aacttttatc cgcgtgaagc aaaagttcag      540

tggaaagttg ataatgcact gcagagcggt aatagccaag aaagcgttac cgaacaggat      600

agcaaagata gcacctatag cctgagcagc accctgaccc tgagcaaagc agattatgaa      660

aaacacaaag tgtatgcctg cgaagttacc catcagggtc tgagcagtcc ggttaccaaa      720

agctttaatc gtggtgaatg ttaattaact cgaggctgag caaagcagac tactaataac      780

ataaagtcta cgccggacgc atcgtggccc tagtacgcaa gttcacgtaa aaagggtaac      840

tagaggttga ggtgatttta tggaaattag cgaagttcag ctggttgaaa gcggtggtgg      900

tctggttcag cctggtggta gcctgcgtct gagctgtgca gcaagcggtt ttaatctgta      960

tagcagctat attcattggg ttcgtcaggc accgggtaaa ggtctggaat gggttgcaag     1020

catttatccg tatagctcat ataccagcta tgccgatagc gttaaaggtc gttttaccat     1080

tagcgcagat accagcaaaa ataccgcata cctgcagatg aatagtctgc gtgcagagga     1140

taccgcagtg tattattgtg cacgttatta tggtttcgcc atggattatt ggggtcaggg     1200

caccctggtt accgttagca gcgcaagcac caaaggtccg agcgtttttc cgctggcacc     1260

gagcagcaaa agcaccagcg gtggcaccgc agcactgggt tgtctggtta aagattattt     1320

tccggaaccg gttaccgtga gctggaatag cggtgcactg accagtggtg ttcatacctt     1380

tccggcagtt ctgcagagca gcggtctgta tagtctgagc agcgttgtta ccgttccgag     1440

cagtagcctg ggcacccaga cctatatttg taatgttaat cataaaccga gcaacaccaa     1500

agtggataaa aaagttgaac cgaaaagctg cgataaaacc catacctaa                 1549


<210>  6
<211>  247
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Beta9-His Tag-light chain

<400>  6

Met Gly Ser Met Leu Phe Arg Val Thr Ile Asn Ser Gly Gly Gly Ser 
1               5                   10                  15      


Gly His His His His His His His His Gly Gly Gly Ser Gly Met Ala 
            20                  25                  30          


Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val 
        35                  40                  45              


Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Val Ser Ser 
    50                  55                  60                  


Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu 
65                  70                  75                  80  


Ile Tyr Ser Ala Ser Ser Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser 
                85                  90                  95      


Gly Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln 
            100                 105                 110         


Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Tyr Tyr Tyr Pro 
        115                 120                 125             


Phe Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala 
    130                 135                 140                 


Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Ser Gln Leu Lys Ser 
145                 150                 155                 160 


Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
                165                 170                 175     


Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
            180                 185                 190         


Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
        195                 200                 205             


Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
    210                 215                 220                 


Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
225                 230                 235                 240 


Ser Phe Asn Arg Gly Glu Cys 
                245         


<210>  7
<211>  229
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  heavy chain

<400>  7

Met Glu Ile Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
1               5                   10                  15      


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn 
            20                  25                  30          


Leu Tyr Ser Ser Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly 
        35                  40                  45              


Leu Glu Trp Val Ala Ser Ile Tyr Pro Tyr Ser Ser Tyr Thr Ser Tyr 
    50                  55                  60                  


Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys 
65                  70                  75                  80  


Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala 
                85                  90                  95      


Val Tyr Tyr Cys Ala Arg Tyr Tyr Gly Phe Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 220                 


Asp Lys Thr His Thr 
225                 


<210>  8
<211>  1549
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Beta10*-L73J

<400>  8
atggtgagcg gttggcgtct gttcaaaaaa atcagcggtg gtggtagcgg tcatcatcac       60

caccatcacc atcatggtgg tggcagtggt atggcaagcg atattcagat gacccagagc      120

ccgagcagcc tgagcgcaag cgttggtgat cgtgttacca ttacctgtcg tgcaagccag      180

agcgttagca gcgcggttgc atggtatcag cagaaaccgg gtaaagcacc gaaactgctg      240

atttatagcg caagcagcct gtatagcggt gttccgagcc gttttagcgg tagccgtagc      300

ggcaccgatt ttaccctgac cattagcagc ctgcagccgg aagattttgc aacctattat      360

tgtcagcagg gctattatta cccgtttacc tttggtcagg gcaccaaagt tgaaattaaa      420

cgtaccgttg cagcaccgag cgtttttatc tttccgccta gcgatagcca gctgaaaagc      480

ggtacagcca gcgttgtttg tctgctgaat aacttttatc cgcgtgaagc aaaagttcag      540

tggaaagttg ataatgcact gcagagcggt aatagccaag aaagcgttac cgaacaggat      600

agcaaagata gcacctatag cctgagcagc accctgaccc tgagcaaagc agattatgaa      660

aaacacaaag tgtatgcctg cgaagttacc catcagggtc tgagcagtcc ggttaccaaa      720

agctttaatc gtggtgaatg ttaattaact cgaggctgag caaagcagac tactaataac      780

ataaagtcta cgccggacgc atcgtggccc tagtacgcaa gttcacgtaa aaagggtaac      840

tagaggttga ggtgatttta tggaaattag cgaagttcag ctggttgaaa gcggtggtgg      900

tctggttcag cctggtggta gcctgcgtct gagctgtgca gcaagcggtt ttaatctgta      960

tagcagctat attcattggg ttcgtcaggc accgggtaaa ggtctggaat gggttgcaag     1020

catttatccg tatagctcat ataccagcta tgccgatagc gttaaaggtc gttttaccat     1080

tagcgcagat accagcaaaa ataccgcata cctgcagatg aatagtctgc gtgcagagga     1140

taccgcagtg tattattgtg cacgttatta tggtttcgcc atggattatt ggggtcaggg     1200

caccctggtt accgttagca gcgcaagcac caaaggtccg agcgtttttc cgctggcacc     1260

gagcagcaaa agcaccagcg gtggcaccgc agcactgggt tgtctggtta aagattattt     1320

tccggaaccg gttaccgtga gctggaatag cggtgcactg accagtggtg ttcatacctt     1380

tccggcagtt ctgcagagca gcggtctgta tagtctgagc agcgttgtta ccgttccgag     1440

cagtagcctg ggcacccaga cctatatttg taatgttaat cataaaccga gcaacaccaa     1500

agtggataaa aaagttgaac cgaaaagctg cgataaaacc catacctaa                 1549


<210>  9
<211>  247
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Beta10*-His Tag-light chain

<400>  9

Met Val Ser Gly Trp Arg Leu Phe Lys Lys Ile Ser Gly Gly Gly Ser 
1               5                   10                  15      


Gly His His His His His His His His Gly Gly Gly Ser Gly Met Ala 
            20                  25                  30          


Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val 
        35                  40                  45              


Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Val Ser Ser 
    50                  55                  60                  


Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu 
65                  70                  75                  80  


Ile Tyr Ser Ala Ser Ser Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser 
                85                  90                  95      


Gly Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln 
            100                 105                 110         


Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Tyr Tyr Tyr Pro 
        115                 120                 125             


Phe Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala 
    130                 135                 140                 


Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Ser Gln Leu Lys Ser 
145                 150                 155                 160 


Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
                165                 170                 175     


Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
            180                 185                 190         


Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
        195                 200                 205             


Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
    210                 215                 220                 


Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
225                 230                 235                 240 


Ser Phe Asn Arg Gly Glu Cys 
                245         


<210>  10
<211>  229
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  heavy chain

<400>  10

Met Glu Ile Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
1               5                   10                  15      


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn 
            20                  25                  30          


Leu Tyr Ser Ser Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly 
        35                  40                  45              


Leu Glu Trp Val Ala Ser Ile Tyr Pro Tyr Ser Ser Tyr Thr Ser Tyr 
    50                  55                  60                  


Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys 
65                  70                  75                  80  


Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala 
                85                  90                  95      


Val Tyr Tyr Cys Ala Arg Tyr Tyr Gly Phe Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 220                 


Asp Lys Thr His Thr 
225                 


<210>  11
<211>  1546
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  73JH-Beta9

<400>  11
atggcaagcg atattcagat gacccagagc ccgagcagcc tgagcgcaag cgttggtgat       60

cgtgttacca ttacctgtcg tgcaagccag agcgttagca gcgcggttgc atggtatcag      120

cagaaaccgg gtaaagcacc gaaactgctg atttatagcg caagcagcct gtatagcggt      180

gttccgagcc gttttagcgg tagccgtagc ggcaccgatt ttaccctgac cattagcagc      240

ctgcagccgg aagattttgc aacctattat tgtcagcagg gctattatta cccgtttacc      300

tttggtcagg gcaccaaagt tgaaattaaa cgtaccgttg cagcaccgag cgtttttatc      360

tttccgccta gcgatagcca gctgaaaagc ggtacagcca gcgttgtttg tctgctgaat      420

aacttttatc cgcgtgaagc aaaagttcag tggaaagttg ataatgcact gcagagcggt      480

aatagccaag aaagcgttac cgaacaggat agcaaagata gcacctatag cctgagcagc      540

accctgaccc tgagcaaagc agattatgaa aaacacaaag tgtatgcctg cgaagttacc      600

catcagggtc tgagcagtcc ggttaccaaa agctttaatc gtggtgaatg ttaattaact      660

cgaggctgag caaagcagac tactaataac ataaagtcta cgccggacgc atcgtggccc      720

tagtacgcaa gttcacgtaa aaagggtaac tagaggttga ggtgatttta tggaaattag      780

cgaagttcag ctggttgaaa gcggtggtgg tctggttcag cctggtggta gcctgcgtct      840

gagctgtgca gcaagcggtt ttaatctgta tagcagctat attcattggg ttcgtcaggc      900

accgggtaaa ggtctggaat gggttgcaag catttatccg tatagctcat ataccagcta      960

tgccgatagc gttaaaggtc gttttaccat tagcgcagat accagcaaaa ataccgcata     1020

cctgcagatg aatagtctgc gtgcagagga taccgcagtg tattattgtg cacgttatta     1080

tggtttcgcc atggattatt ggggtcaggg caccctggtt accgttagca gcgcaagcac     1140

caaaggtccg agcgtttttc cgctggcacc gagcagcaaa agcaccagcg gtggcaccgc     1200

agcactgggt tgtctggtta aagattattt tccggaaccg gttaccgtga gctggaatag     1260

cggtgcactg accagtggtg ttcatacctt tccggcagtt ctgcagagca gcggtctgta     1320

tagtctgagc agcgttgtta ccgttccgag cagtagcctg ggcacccaga cctatatttg     1380

taatgttaat cataaaccga gcaacaccaa agtggataaa aaagttgaac cgaaaagctg     1440

cgataaaacc cataccggtg gtggtagcgg tcatcatcac caccatcacc atcatggtgg     1500

tggcagtggt ggtagtatgc tgtttcgtgt taccattaac agctaa                    1546


<210>  12
<211>  217
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  light chain

<400>  12

Met Ala Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
1               5                   10                  15      


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Val 
            20                  25                  30          


Ser Ser Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys 
        35                  40                  45              


Leu Leu Ile Tyr Ser Ala Ser Ser Leu Tyr Ser Gly Val Pro Ser Arg 
    50                  55                  60                  


Phe Ser Gly Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 
65                  70                  75                  80  


Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Tyr Tyr 
                85                  90                  95      


Tyr Pro Phe Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr 
            100                 105                 110         


Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Ser Gln Leu 
        115                 120                 125             


Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro 
    130                 135                 140                 


Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly 
145                 150                 155                 160 


Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr 
                165                 170                 175     


Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His 
            180                 185                 190         


Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val 
        195                 200                 205             


Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215         


<210>  13
<211>  258
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  heavy chain-His Tag-Beta9

<400>  13

Met Glu Ile Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
1               5                   10                  15      


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn 
            20                  25                  30          


Leu Tyr Ser Ser Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly 
        35                  40                  45              


Leu Glu Trp Val Ala Ser Ile Tyr Pro Tyr Ser Ser Tyr Thr Ser Tyr 
    50                  55                  60                  


Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys 
65                  70                  75                  80  


Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala 
                85                  90                  95      


Val Tyr Tyr Cys Ala Arg Tyr Tyr Gly Phe Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 220                 


Asp Lys Thr His Thr Gly Gly Gly Ser Gly His His His His His His 
225                 230                 235                 240 


His His Gly Gly Gly Ser Gly Gly Ser Met Leu Phe Arg Val Thr Ile 
                245                 250                 255     


Asn Ser 
        


<210>  14
<211>  1546
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  73JH-Beta10*

<400>  14
atggcaagcg atattcagat gacccagagc ccgagcagcc tgagcgcaag cgttggtgat       60

cgtgttacca ttacctgtcg tgcaagccag agcgttagca gcgcggttgc atggtatcag      120

cagaaaccgg gtaaagcacc gaaactgctg atttatagcg caagcagcct gtatagcggt      180

gttccgagcc gttttagcgg tagccgtagc ggcaccgatt ttaccctgac cattagcagc      240

ctgcagccgg aagattttgc aacctattat tgtcagcagg gctattatta cccgtttacc      300

tttggtcagg gcaccaaagt tgaaattaaa cgtaccgttg cagcaccgag cgtttttatc      360

tttccgccta gcgatagcca gctgaaaagc ggtacagcca gcgttgtttg tctgctgaat      420

aacttttatc cgcgtgaagc aaaagttcag tggaaagttg ataatgcact gcagagcggt      480

aatagccaag aaagcgttac cgaacaggat agcaaagata gcacctatag cctgagcagc      540

accctgaccc tgagcaaagc agattatgaa aaacacaaag tgtatgcctg cgaagttacc      600

catcagggtc tgagcagtcc ggttaccaaa agctttaatc gtggtgaatg ttaattaact      660

cgaggctgag caaagcagac tactaataac ataaagtcta cgccggacgc atcgtggccc      720

tagtacgcaa gttcacgtaa aaagggtaac tagaggttga ggtgatttta tggaaattag      780

cgaagttcag ctggttgaaa gcggtggtgg tctggttcag cctggtggta gcctgcgtct      840

gagctgtgca gcaagcggtt ttaatctgta tagcagctat attcattggg ttcgtcaggc      900

accgggtaaa ggtctggaat gggttgcaag catttatccg tatagctcat ataccagcta      960

tgccgatagc gttaaaggtc gttttaccat tagcgcagat accagcaaaa ataccgcata     1020

cctgcagatg aatagtctgc gtgcagagga taccgcagtg tattattgtg cacgttatta     1080

tggtttcgcc atggattatt ggggtcaggg caccctggtt accgttagca gcgcaagcac     1140

caaaggtccg agcgtttttc cgctggcacc gagcagcaaa agcaccagcg gtggcaccgc     1200

agcactgggt tgtctggtta aagattattt tccggaaccg gttaccgtga gctggaatag     1260

cggtgcactg accagtggtg ttcatacctt tccggcagtt ctgcagagca gcggtctgta     1320

tagtctgagc agcgttgtta ccgttccgag cagtagcctg ggcacccaga cctatatttg     1380

taatgttaat cataaaccga gcaacaccaa agtggataaa aaagttgaac cgaaaagctg     1440

cgataaaacc cataccggtg gtggtagcgg tcatcatcac caccatcacc atcatggtgg     1500

tggcagtggt gtgagcggtt ggcgtctgtt caaaaaaatc agctaa                    1546


<210>  15
<211>  217
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  light chain

<400>  15

Met Ala Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
1               5                   10                  15      


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Val 
            20                  25                  30          


Ser Ser Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys 
        35                  40                  45              


Leu Leu Ile Tyr Ser Ala Ser Ser Leu Tyr Ser Gly Val Pro Ser Arg 
    50                  55                  60                  


Phe Ser Gly Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 
65                  70                  75                  80  


Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Tyr Tyr 
                85                  90                  95      


Tyr Pro Phe Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr 
            100                 105                 110         


Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Ser Gln Leu 
        115                 120                 125             


Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro 
    130                 135                 140                 


Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly 
145                 150                 155                 160 


Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr 
                165                 170                 175     


Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His 
            180                 185                 190         


Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val 
        195                 200                 205             


Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215         


<210>  16
<211>  258
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  heavy chain-HisTag-Beta9

<400>  16

Met Glu Ile Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
1               5                   10                  15      


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn 
            20                  25                  30          


Leu Tyr Ser Ser Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly 
        35                  40                  45              


Leu Glu Trp Val Ala Ser Ile Tyr Pro Tyr Ser Ser Tyr Thr Ser Tyr 
    50                  55                  60                  


Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys 
65                  70                  75                  80  


Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala 
                85                  90                  95      


Val Tyr Tyr Cys Ala Arg Tyr Tyr Gly Phe Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 220                 


Asp Lys Thr His Thr Gly Gly Gly Ser Gly His His His His His His 
225                 230                 235                 240 


His His Gly Gly Gly Ser Gly Val Ser Gly Trp Arg Leu Phe Lys Lys 
                245                 250                 255     


Ile Ser 
        


<210>  17
<211>  1555
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Beta9-HTras

<400>  17
atggcaagcg atattcagat gacccagagc ccgagcagcc tgagcgcaag cgttggtgat       60

cgtgttacca ttacctgtcg tgcaagccag gatgttaata ccgcagttgc atggtatcag      120

cagaaaccgg gtaaagcacc gaaactgctg atttatagcg caagctttct gtatagcggt      180

gttccgagcc gttttagcgg tagccgtagc ggcaccgatt ttaccctgac cattagcagc      240

ctgcagccgg aagattttgc aacctattat tgtcagcagc attacaccac ccctccgacc      300

tttggtcagg gcaccaaagt tgaaattaaa cgtaccgttg cagcaccgag cgtttttatc      360

tttccgccta gcgatgagca gctgaaaagc ggtacagcca gcgttgtttg tctgctgaat      420

aacttttatc cgcgtgaagc aaaagttcag tggaaagttg ataatgcact gcagagcggt      480

aatagccaag aaagcgttac cgaacaggat agcaaagata gcacctatag cctgagcagc      540

accctgaccc tgagcaaagc agattatgaa aaacacaaag tgtatgcctg cgaagttacc      600

catcagggtc tgagcagtcc ggttaccaaa agctttaatc gtggtgaatg ttaattaact      660

cgaggctgag caaagcagac tactaataac ataaagtcta cgccggacgc atcgtggccc      720

tagtacgcaa gttcacgtaa aaagggtaac tagaggttga ggtgatttta tgggtagtat      780

gctgtttcgt gttaccatta acagcggtgg tggtagcggt catcatcacc accatcacca      840

tcatggtggt ggcagtggtg aaattagcga agttcagctg gttgaaagcg gtggtggtct      900

ggttcagcct ggtggtagcc tgcgtctgag ctgtgcagca agcggtttta acattaaaga      960

tacctatatc cactgggttc gtcaggcacc gggtaaaggt ctggaatggg ttgcacgtat     1020

ttatccgacc aatggttata cccgttatgc cgatagcgtt aaaggtcgtt ttaccattag     1080

cgcagatacc agcaaaaata ccgcatacct gcagatgaat agtctgcgtg cagaggatac     1140

cgcagtgtat tattgtagcc gttggggtgg tgatggtttt tatgcaatgg attattgggg     1200

tcagggcacc ctggttaccg ttagcagcgc aagcaccaaa ggtccgagcg tttttccgct     1260

ggcaccgagc agcaaaagca ccagcggtgg caccgcagca ctgggttgtc tggttaaaga     1320

ttattttccg gaaccggtta ccgtgagctg gaatagcggt gcactgacca gtggtgttca     1380

tacctttccg gcagttctgc agagcagcgg tctgtatagt ctgagcagcg ttgttaccgt     1440

tccgagcagt agcctgggca cccagaccta tatttgtaat gttaatcata aaccgagcaa     1500

caccaaagtg gataaaaaag ttgaaccgaa aagctgcgat aaaacccata cctaa          1555


<210>  18
<211>  217
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  light chain

<400>  18

Met Ala Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
1               5                   10                  15      


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val 
            20                  25                  30          


Asn Thr Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys 
        35                  40                  45              


Leu Leu Ile Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg 
    50                  55                  60                  


Phe Ser Gly Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 
65                  70                  75                  80  


Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr Thr 
                85                  90                  95      


Thr Pro Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr 
            100                 105                 110         


Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu 
        115                 120                 125             


Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro 
    130                 135                 140                 


Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly 
145                 150                 155                 160 


Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr 
                165                 170                 175     


Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His 
            180                 185                 190         


Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val 
        195                 200                 205             


Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215         


<210>  19
<211>  261
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Beta9-His Tag-heavy chain

<400>  19

Met Gly Ser Met Leu Phe Arg Val Thr Ile Asn Ser Gly Gly Gly Ser 
1               5                   10                  15      


Gly His His His His His His His His Gly Gly Gly Ser Gly Glu Ile 
            20                  25                  30          


Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 
        35                  40                  45              


Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp 
    50                  55                  60                  


Thr Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
65                  70                  75                  80  


Val Ala Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala Asp Ser 
                85                  90                  95      


Val Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala 
            100                 105                 110         


Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 
        115                 120                 125             


Cys Ser Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr Trp Gly 
    130                 135                 140                 


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
145                 150                 155                 160 


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
                165                 170                 175     


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
            180                 185                 190         


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
        195                 200                 205             


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
    210                 215                 220                 


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
225                 230                 235                 240 


Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
                245                 250                 255     


Asp Lys Thr His Thr 
            260     


<210>  20
<211>  1555
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Beta10*-HTras

<400>  20
atggcaagcg atattcagat gacccagagc ccgagcagcc tgagcgcaag cgttggtgat       60

cgtgttacca ttacctgtcg tgcaagccag gatgttaata ccgcagttgc atggtatcag      120

cagaaaccgg gtaaagcacc gaaactgctg atttatagcg caagctttct gtatagcggt      180

gttccgagcc gttttagcgg tagccgtagc ggcaccgatt ttaccctgac cattagcagc      240

ctgcagccgg aagattttgc aacctattat tgtcagcagc attacaccac ccctccgacc      300

tttggtcagg gcaccaaagt tgaaattaaa cgtaccgttg cagcaccgag cgtttttatc      360

tttccgccta gcgatgagca gctgaaaagc ggtacagcca gcgttgtttg tctgctgaat      420

aacttttatc cgcgtgaagc aaaagttcag tggaaagttg ataatgcact gcagagcggt      480

aatagccaag aaagcgttac cgaacaggat agcaaagata gcacctatag cctgagcagc      540

accctgaccc tgagcaaagc agattatgaa aaacacaaag tgtatgcctg cgaagttacc      600

catcagggtc tgagcagtcc ggttaccaaa agctttaatc gtggtgaatg ttaattaact      660

cgaggctgag caaagcagac tactaataac ataaagtcta cgccggacgc atcgtggccc      720

tagtacgcaa gttcacgtaa aaagggtaac tagaggttga ggtgatttta tggtgagcgg      780

ttggcgtctg ttcaaaaaaa tcagcggtgg tggtagcggt catcatcacc accatcacca      840

tcatggtggt ggcagtggtg aaattagcga agttcagctg gttgaaagcg gtggtggtct      900

ggttcagcct ggtggtagcc tgcgtctgag ctgtgcagca agcggtttta acattaaaga      960

tacctatatc cactgggttc gtcaggcacc gggtaaaggt ctggaatggg ttgcacgtat     1020

ttatccgacc aatggttata cccgttatgc cgatagcgtt aaaggtcgtt ttaccattag     1080

cgcagatacc agcaaaaata ccgcatacct gcagatgaat agtctgcgtg cagaggatac     1140

cgcagtgtat tattgtagcc gttggggtgg tgatggtttt tatgcaatgg attattgggg     1200

tcagggcacc ctggttaccg ttagcagcgc aagcaccaaa ggtccgagcg tttttccgct     1260

ggcaccgagc agcaaaagca ccagcggtgg caccgcagca ctgggttgtc tggttaaaga     1320

ttattttccg gaaccggtta ccgtgagctg gaatagcggt gcactgacca gtggtgttca     1380

tacctttccg gcagttctgc agagcagcgg tctgtatagt ctgagcagcg ttgttaccgt     1440

tccgagcagt agcctgggca cccagaccta tatttgtaat gttaatcata aaccgagcaa     1500

caccaaagtg gataaaaaag ttgaaccgaa aagctgcgat aaaacccata cctaa          1555


<210>  21
<211>  217
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  light chain

<400>  21

Met Ala Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
1               5                   10                  15      


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val 
            20                  25                  30          


Asn Thr Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys 
        35                  40                  45              


Leu Leu Ile Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg 
    50                  55                  60                  


Phe Ser Gly Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 
65                  70                  75                  80  


Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr Thr 
                85                  90                  95      


Thr Pro Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr 
            100                 105                 110         


Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu 
        115                 120                 125             


Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro 
    130                 135                 140                 


Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly 
145                 150                 155                 160 


Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr 
                165                 170                 175     


Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His 
            180                 185                 190         


Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val 
        195                 200                 205             


Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215         


<210>  22
<211>  261
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Beta10*-His Tag-heavy chain

<400>  22

Met Val Ser Gly Trp Arg Leu Phe Lys Lys Ile Ser Gly Gly Gly Ser 
1               5                   10                  15      


Gly His His His His His His His His Gly Gly Gly Ser Gly Glu Ile 
            20                  25                  30          


Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 
        35                  40                  45              


Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp 
    50                  55                  60                  


Thr Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
65                  70                  75                  80  


Val Ala Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala Asp Ser 
                85                  90                  95      


Val Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala 
            100                 105                 110         


Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 
        115                 120                 125             


Cys Ser Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr Trp Gly 
    130                 135                 140                 


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
145                 150                 155                 160 


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
                165                 170                 175     


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
            180                 185                 190         


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
        195                 200                 205             


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
    210                 215                 220                 


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
225                 230                 235                 240 


Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
                245                 250                 255     


Asp Lys Thr His Thr 
            260     


<210>  23
<211>  1555
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TrasH-Beta9

<400>  23
atggcaagcg atattcagat gacccagagc ccgagcagcc tgagcgcaag cgttggtgat       60

cgtgttacca ttacctgtcg tgcaagccag gatgttaata ccgcagttgc atggtatcag      120

cagaaaccgg gtaaagcacc gaaactgctg atttatagcg caagctttct gtatagcggt      180

gttccgagcc gttttagcgg tagccgtagc ggcaccgatt ttaccctgac cattagcagc      240

ctgcagccgg aagattttgc aacctattat tgtcagcagc attacaccac ccctccgacc      300

tttggtcagg gcaccaaagt tgaaattaaa cgtaccgttg cagcaccgag cgtttttatc      360

tttccgccta gcgatgagca gctgaaaagc ggtacagcca gcgttgtttg tctgctgaat      420

aacttttatc cgcgtgaagc aaaagttcag tggaaagttg ataatgcact gcagagcggt      480

aatagccaag aaagcgttac cgaacaggat agcaaagata gcacctatag cctgagcagc      540

accctgaccc tgagcaaagc agattatgaa aaacacaaag tgtatgcctg cgaagttacc      600

catcagggtc tgagcagtcc ggttaccaaa agctttaatc gtggtgaatg ttaattaact      660

cgaggctgag caaagcagac tactaataac ataaagtcta cgccggacgc atcgtggccc      720

tagtacgcaa gttcacgtaa aaagggtaac tagaggttga ggtgatttta tggaaattag      780

cgaagttcag ctggttgaaa gcggtggtgg tctggttcag cctggtggta gcctgcgtct      840

gagctgtgca gcaagcggtt ttaacattaa agatacctat atccactggg ttcgtcaggc      900

accgggtaaa ggtctggaat gggttgcacg tatttatccg accaatggtt atacccgtta      960

tgccgatagc gttaaaggtc gttttaccat tagcgcagat accagcaaaa ataccgcata     1020

cctgcagatg aatagtctgc gtgcagagga taccgcagtg tattattgta gccgttgggg     1080

tggtgatggt ttttatgcaa tggattattg gggtcagggc accctggtta ccgttagcag     1140

cgcaagcacc aaaggtccga gcgtttttcc gctggcaccg agcagcaaaa gcaccagcgg     1200

tggcaccgca gcactgggtt gtctggttaa agattatttt ccggaaccgg ttaccgtgag     1260

ctggaatagc ggtgcactga ccagtggtgt tcataccttt ccggcagttc tgcagagcag     1320

cggtctgtat agtctgagca gcgttgttac cgttccgagc agtagcctgg gcacccagac     1380

ctatatttgt aatgttaatc ataaaccgag caacaccaaa gtggataaaa aagttgaacc     1440

gaaaagctgc gataaaaccc ataccggtgg tggtagcggt catcatcacc accatcacca     1500

tcatggtggt ggcagtggtg gtagtatgct gtttcgtgtt accattaaca gctaa          1555


<210>  24
<211>  217
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  light chain

<400>  24

Met Ala Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
1               5                   10                  15      


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val 
            20                  25                  30          


Asn Thr Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys 
        35                  40                  45              


Leu Leu Ile Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg 
    50                  55                  60                  


Phe Ser Gly Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 
65                  70                  75                  80  


Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr Thr 
                85                  90                  95      


Thr Pro Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr 
            100                 105                 110         


Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu 
        115                 120                 125             


Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro 
    130                 135                 140                 


Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly 
145                 150                 155                 160 


Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr 
                165                 170                 175     


Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His 
            180                 185                 190         


Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val 
        195                 200                 205             


Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215         


<210>  25
<211>  261
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  heavy chain-His Tag-Beta9

<400>  25

Met Glu Ile Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
1               5                   10                  15      


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn 
            20                  25                  30          


Ile Lys Asp Thr Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly 
        35                  40                  45              


Leu Glu Trp Val Ala Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr 
    50                  55                  60                  


Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys 
65                  70                  75                  80  


Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala 
                85                  90                  95      


Val Tyr Tyr Cys Ser Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys 
        115                 120                 125             


Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly 
    130                 135                 140                 


Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
145                 150                 155                 160 


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
                165                 170                 175     


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
            180                 185                 190         


Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn 
        195                 200                 205             


Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro 
    210                 215                 220                 


Lys Ser Cys Asp Lys Thr His Thr Gly Gly Gly Ser Gly His His His 
225                 230                 235                 240 


His His His His His Gly Gly Gly Ser Gly Gly Ser Met Leu Phe Arg 
                245                 250                 255     


Val Thr Ile Asn Ser 
            260     


<210>  26
<211>  1555
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TrasH-Beta10*

<400>  26
atggcaagcg atattcagat gacccagagc ccgagcagcc tgagcgcaag cgttggtgat       60

cgtgttacca ttacctgtcg tgcaagccag gatgttaata ccgcagttgc atggtatcag      120

cagaaaccgg gtaaagcacc gaaactgctg atttatagcg caagctttct gtatagcggt      180

gttccgagcc gttttagcgg tagccgtagc ggcaccgatt ttaccctgac cattagcagc      240

ctgcagccgg aagattttgc aacctattat tgtcagcagc attacaccac ccctccgacc      300

tttggtcagg gcaccaaagt tgaaattaaa cgtaccgttg cagcaccgag cgtttttatc      360

tttccgccta gcgatgagca gctgaaaagc ggtacagcca gcgttgtttg tctgctgaat      420

aacttttatc cgcgtgaagc aaaagttcag tggaaagttg ataatgcact gcagagcggt      480

aatagccaag aaagcgttac cgaacaggat agcaaagata gcacctatag cctgagcagc      540

accctgaccc tgagcaaagc agattatgaa aaacacaaag tgtatgcctg cgaagttacc      600

catcagggtc tgagcagtcc ggttaccaaa agctttaatc gtggtgaatg ttaattaact      660

cgaggctgag caaagcagac tactaataac ataaagtcta cgccggacgc atcgtggccc      720

tagtacgcaa gttcacgtaa aaagggtaac tagaggttga ggtgatttta tggaaattag      780

cgaagttcag ctggttgaaa gcggtggtgg tctggttcag cctggtggta gcctgcgtct      840

gagctgtgca gcaagcggtt ttaacattaa agatacctat atccactggg ttcgtcaggc      900

accgggtaaa ggtctggaat gggttgcacg tatttatccg accaatggtt atacccgtta      960

tgccgatagc gttaaaggtc gttttaccat tagcgcagat accagcaaaa ataccgcata     1020

cctgcagatg aatagtctgc gtgcagagga taccgcagtg tattattgta gccgttgggg     1080

tggtgatggt ttttatgcaa tggattattg gggtcagggc accctggtta ccgttagcag     1140

cgcaagcacc aaaggtccga gcgtttttcc gctggcaccg agcagcaaaa gcaccagcgg     1200

tggcaccgca gcactgggtt gtctggttaa agattatttt ccggaaccgg ttaccgtgag     1260

ctggaatagc ggtgcactga ccagtggtgt tcataccttt ccggcagttc tgcagagcag     1320

cggtctgtat agtctgagca gcgttgttac cgttccgagc agtagcctgg gcacccagac     1380

ctatatttgt aatgttaatc ataaaccgag caacaccaaa gtggataaaa aagttgaacc     1440

gaaaagctgc gataaaaccc ataccggtgg tggtagcggt catcatcacc accatcacca     1500

tcatggtggt ggcagtggtg tgagcggttg gcgtctgttc aaaaaaatca gctaa          1555


<210>  27
<211>  217
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  light chain

<400>  27

Met Ala Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
1               5                   10                  15      


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val 
            20                  25                  30          


Asn Thr Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys 
        35                  40                  45              


Leu Leu Ile Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg 
    50                  55                  60                  


Phe Ser Gly Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 
65                  70                  75                  80  


Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr Thr 
                85                  90                  95      


Thr Pro Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr 
            100                 105                 110         


Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu 
        115                 120                 125             


Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro 
    130                 135                 140                 


Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly 
145                 150                 155                 160 


Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr 
                165                 170                 175     


Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His 
            180                 185                 190         


Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val 
        195                 200                 205             


Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215         


<210>  28
<211>  261
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  heavy chain-His Tag-Beta10*)

<400>  28

Met Glu Ile Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
1               5                   10                  15      


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn 
            20                  25                  30          


Ile Lys Asp Thr Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly 
        35                  40                  45              


Leu Glu Trp Val Ala Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr 
    50                  55                  60                  


Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys 
65                  70                  75                  80  


Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala 
                85                  90                  95      


Val Tyr Tyr Cys Ser Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys 
        115                 120                 125             


Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly 
    130                 135                 140                 


Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
145                 150                 155                 160 


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
                165                 170                 175     


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
            180                 185                 190         


Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn 
        195                 200                 205             


Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro 
    210                 215                 220                 


Lys Ser Cys Asp Lys Thr His Thr Gly Gly Gly Ser Gly His His His 
225                 230                 235                 240 


His His His His His Gly Gly Gly Ser Gly Val Ser Gly Trp Arg Leu 
                245                 250                 255     


Phe Lys Lys Ile Ser 
            260     


<210>  29
<211>  1555
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Beta9-LPert

<400>  29
atgggtagta tgctgtttcg tgttaccatt aacagcggtg gtggtagcgg tcatcatcac       60

caccatcacc atcatggtgg tggcagtggt atggcaagcg atattcagat gacccagagc      120

ccgagcagcc tgagcgcaag cgttggtgat cgtgttacca ttacctgtaa ggcaagccag      180

gatgttagca ttggtgttgc atggtatcag cagaaaccgg gtaaagcacc gaaactgctg      240

atttatagcg caagctatcg ttataccggt gttccgagcc gttttagcgg tagcggcagc      300

ggcaccgatt ttaccctgac cattagcagc ctgcagccgg aagattttgc aacctattat      360

tgtcagcagt actacatcta tccgtacacc tttggtcagg gcaccaaagt tgaaattaaa      420

cgtaccgttg cagcaccgag cgtttttatc ttcccgccta gcgatgagca gctgaaaagc      480

ggtacagcca gcgttgtttg tctgctgaat aacttttatc cgcgtgaggc aaaagttcag      540

tggaaagttg ataatgcact gcagagcggt aatagccaag aaagcgttac cgaacaggat      600

agcaaagata gcacctatag cctgagcagc accctgaccc tgagcaaagc agattatgaa      660

aaacacaaag tgtatgcctg cgaagttacc catcagggtc tgagcagtcc ggttaccaaa      720

agctttaatc gtggtgaatg ttaattaact cgaggctgag caaagcagac tactaataac      780

ataaagtcta cgccggacgc atcgtggccc tagtacgcaa gttcacgtaa aaagggtaac      840

tagaggttga ggtgatttta tggaaattag cgaagttcag ctggttgaaa gcggtggtgg      900

tctggttcag cctggtggta gcctgcgtct gagctgtgca gcaagcggtt ttacctttac      960

cgattacacc atggattggg ttcgtcaggc accgggtaaa ggtctggaat gggttgcaga     1020

tgttaatccg aatagcggtg gtagcattta taaccagcgt tttaaaggtc gttttaccct     1080

gagcgttgat cgtagcaaaa ataccctgta tctgcaaatg aatagtctgc gtgcagagga     1140

taccgcagtg tattattgtg cacgtaatct gggtccgagc ttctattttg attattgggg     1200

tcagggcacc ctggttaccg ttagcagcgc aagcaccaaa ggtccgagcg tttttccgct     1260

ggcaccgagc agcaaaagca ccagcggtgg caccgcagca ctgggttgtc tggttaaaga     1320

ttattttccg gaaccggtta ccgtgagctg gaatagcggt gcactgacca gtggtgttca     1380

tacctttccg gcagttctgc agagcagcgg tctgtatagt ctgagcagcg ttgttaccgt     1440

tccgagcagt agcctgggca cccagaccta tatttgtaat gttaatcata aaccgagcaa     1500

caccaaagtg gataaaaaag ttgaaccgaa aagctgcgat aaaacccata cctaa          1555


<210>  30
<211>  247
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Beta9-His Tag-light chain

<400>  30

Met Gly Ser Met Leu Phe Arg Val Thr Ile Asn Ser Gly Gly Gly Ser 
1               5                   10                  15      


Gly His His His His His His His His Gly Gly Gly Ser Gly Met Ala 
            20                  25                  30          


Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val 
        35                  40                  45              


Gly Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Val Ser Ile 
    50                  55                  60                  


Gly Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu 
65                  70                  75                  80  


Ile Tyr Ser Ala Ser Tyr Arg Tyr Thr Gly Val Pro Ser Arg Phe Ser 
                85                  90                  95      


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln 
            100                 105                 110         


Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Tyr Ile Tyr Pro 
        115                 120                 125             


Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala 
    130                 135                 140                 


Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
145                 150                 155                 160 


Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
                165                 170                 175     


Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
            180                 185                 190         


Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
        195                 200                 205             


Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
    210                 215                 220                 


Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
225                 230                 235                 240 


Ser Phe Asn Arg Gly Glu Cys 
                245         


<210>  31
<211>  231
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  heavy chain

<400>  31

Met Glu Ile Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
1               5                   10                  15      


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr 
            20                  25                  30          


Phe Thr Asp Tyr Thr Met Asp Trp Val Arg Gln Ala Pro Gly Lys Gly 
        35                  40                  45              


Leu Glu Trp Val Ala Asp Val Asn Pro Asn Ser Gly Gly Ser Ile Tyr 
    50                  55                  60                  


Asn Gln Arg Phe Lys Gly Arg Phe Thr Leu Ser Val Asp Arg Ser Lys 
65                  70                  75                  80  


Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala 
                85                  90                  95      


Val Tyr Tyr Cys Ala Arg Asn Leu Gly Pro Ser Phe Tyr Phe Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly 
        115                 120                 125             


Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly 
    130                 135                 140                 


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
145                 150                 155                 160 


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
                165                 170                 175     


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
            180                 185                 190         


Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val 
        195                 200                 205             


Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys 
    210                 215                 220                 


Ser Cys Asp Lys Thr His Thr 
225                 230     


<210>  32
<211>  1555
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Beta10*-LPert

<400>  32
atggtgagcg gttggcgtct gttcaaaaaa atcagcggtg gtggtagcgg tcatcatcac       60

caccatcacc atcatggtgg tggcagtggt atggcaagcg atattcagat gacccagagc      120

ccgagcagcc tgagcgcaag cgttggtgat cgtgttacca ttacctgtaa ggcaagccag      180

gatgttagca ttggtgttgc atggtatcag cagaaaccgg gtaaagcacc gaaactgctg      240

atttatagcg caagctatcg ttataccggt gttccgagcc gttttagcgg tagcggcagc      300

ggcaccgatt ttaccctgac cattagcagc ctgcagccgg aagattttgc aacctattat      360

tgtcagcagt actacatcta tccgtacacc tttggtcagg gcaccaaagt tgaaattaaa      420

cgtaccgttg cagcaccgag cgtttttatc tttccgccta gcgatgagca gctgaaaagc      480

ggtacagcca gcgttgtttg tctgctgaat aacttttatc cgcgtgaagc aaaagttcag      540

tggaaagttg ataatgcact gcagagcggt aatagccaag aaagcgttac cgaacaggat      600

agcaaagata gcacctatag cctgagcagc accctgaccc tgagcaaagc agattatgaa      660

aaacacaaag tgtatgcctg cgaagttacc catcagggtc tgagcagtcc ggttaccaaa      720

agctttaatc gtggtgaatg ttaattaact cgaggctgag caaagcagac tactaataac      780

ataaagtcta cgccggacgc atcgtggccc tagtacgcaa gttcacgtaa aaagggtaac      840

tagaggttga ggtgatttta tggaaattag cgaagttcag ctggttgaaa gcggtggtgg      900

tctggttcag cctggtggta gcctgcgtct gagctgtgca gcaagcggtt ttacctttac      960

cgattacacc atggattggg ttcgtcaggc accgggtaaa ggtctggaat gggttgcaga     1020

tgttaatccg aatagcggtg gtagcattta taaccagcgt tttaaaggtc gttttaccct     1080

gagcgttgat cgtagcaaaa ataccctgta tctgcaaatg aatagtctgc gtgcagagga     1140

taccgcagtg tattattgtg cacgtaatct gggtccgagc ttctattttg attattgggg     1200

tcagggcacc ctggttaccg ttagcagcgc aagcaccaaa ggtccgagcg tttttccgct     1260

ggcaccgagc agcaaaagca ccagcggtgg caccgcagca ctgggttgtc tggttaaaga     1320

ttattttccg gaaccggtta ccgtgagctg gaatagcggt gcactgacca gtggtgttca     1380

tacctttccg gcagttctgc agagcagcgg tctgtatagt ctgagcagcg ttgttaccgt     1440

tccgagcagt agcctgggca cccagaccta tatttgtaat gttaatcata aaccgagcaa     1500

caccaaagtg gataaaaaag ttgaaccgaa aagctgcgat aaaacccata cctaa          1555


<210>  33
<211>  247
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Beta10*-His Tag-light chain

<400>  33

Met Val Ser Gly Trp Arg Leu Phe Lys Lys Ile Ser Gly Gly Gly Ser 
1               5                   10                  15      


Gly His His His His His His His His Gly Gly Gly Ser Gly Met Ala 
            20                  25                  30          


Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val 
        35                  40                  45              


Gly Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Val Ser Ile 
    50                  55                  60                  


Gly Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu 
65                  70                  75                  80  


Ile Tyr Ser Ala Ser Tyr Arg Tyr Thr Gly Val Pro Ser Arg Phe Ser 
                85                  90                  95      


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln 
            100                 105                 110         


Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Tyr Ile Tyr Pro 
        115                 120                 125             


Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala 
    130                 135                 140                 


Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
145                 150                 155                 160 


Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
                165                 170                 175     


Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
            180                 185                 190         


Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
        195                 200                 205             


Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
    210                 215                 220                 


Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
225                 230                 235                 240 


Ser Phe Asn Arg Gly Glu Cys 
                245         


<210>  34
<211>  231
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  heavy chain

<400>  34

Met Glu Ile Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
1               5                   10                  15      


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr 
            20                  25                  30          


Phe Thr Asp Tyr Thr Met Asp Trp Val Arg Gln Ala Pro Gly Lys Gly 
        35                  40                  45              


Leu Glu Trp Val Ala Asp Val Asn Pro Asn Ser Gly Gly Ser Ile Tyr 
    50                  55                  60                  


Asn Gln Arg Phe Lys Gly Arg Phe Thr Leu Ser Val Asp Arg Ser Lys 
65                  70                  75                  80  


Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala 
                85                  90                  95      


Val Tyr Tyr Cys Ala Arg Asn Leu Gly Pro Ser Phe Tyr Phe Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly 
        115                 120                 125             


Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly 
    130                 135                 140                 


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
145                 150                 155                 160 


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
                165                 170                 175     


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
            180                 185                 190         


Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val 
        195                 200                 205             


Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys 
    210                 215                 220                 


Ser Cys Asp Lys Thr His Thr 
225                 230     


<210>  35
<211>  1552
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PertH-Beta9

<400>  35
atggcaagcg atattcagat gacccagagc ccgagcagcc tgagcgcaag cgttggtgat       60

cgtgttacca ttacctgtaa ggcaagccag gatgttagca ttggtgttgc atggtatcag      120

cagaaaccgg gtaaagcacc gaaactgctg atttatagcg caagctatcg ttataccggt      180

gttccgagcc gttttagcgg tagcggcagc ggcaccgatt ttaccctgac cattagcagc      240

ctgcagccgg aagattttgc aacctattat tgtcagcagt actacatcta tccgtacacc      300

tttggtcagg gcaccaaagt tgaaattaaa cgtaccgttg cagcaccgag cgtttttatc      360

tttccgccta gcgatgagca gctgaaaagc ggtacagcca gcgttgtttg tctgctgaat      420

aacttttatc cgcgtgaagc aaaagttcag tggaaagttg ataatgcact gcagagcggt      480

aatagccaag aaagcgttac cgaacaggat agcaaagata gcacctatag cctgagcagc      540

accctgaccc tgagcaaagc agattatgaa aaacacaaag tgtatgcctg cgaagttacc      600

catcagggtc tgagcagtcc ggttaccaaa agctttaatc gtggtgaatg ttaattaact      660

cgaggctgag caaagcagac tactaataac ataaagtcta cgccggacgc atcgtggccc      720

tagtacgcaa gttcacgtaa aaagggtaac tagaggttga ggtgatttta tggaaattag      780

cgaagttcag ctggttgaaa gcggtggtgg tctggttcag cctggtggta gcctgcgtct      840

gagctgtgca gcaagcggtt ttacctttac cgattacacc atggattggg ttcgtcaggc      900

accgggtaaa ggtctggaat gggttgcaga tgttaatccg aatagcggtg gtagcattta      960

taaccagcgt tttaaaggtc gttttaccct gagcgttgat cgtagcaaaa ataccctgta     1020

tctgcaaatg aatagtctgc gtgcagagga taccgcagtg tattattgtg cacgtaatct     1080

gggtccgagc ttctattttg attattgggg tcagggcacc ctggttaccg ttagcagcgc     1140

aagcaccaaa ggtccgagcg tttttccgct ggcaccgagc agcaaaagca ccagcggtgg     1200

caccgcagca ctgggttgtc tggttaaaga ttattttccg gaaccggtta ccgtgagctg     1260

gaatagcggt gcactgacca gtggtgttca tacctttccg gcagttctgc agagcagcgg     1320

tctgtatagt ctgagcagcg ttgttaccgt tccgagcagt agcctgggca cccagaccta     1380

tatttgtaat gttaatcata aaccgagcaa caccaaagtg gataaaaaag ttgaaccgaa     1440

aagctgcgat aaaacccata ccggtggtgg tagcggtcat catcaccacc atcaccatca     1500

tggtggtggc agtggtggta gtatgctgtt tcgtgttacc attaacagct aa             1552


<210>  36
<211>  217
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  light chain

<400>  36

Met Ala Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
1               5                   10                  15      


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Val 
            20                  25                  30          


Ser Ile Gly Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys 
        35                  40                  45              


Leu Leu Ile Tyr Ser Ala Ser Tyr Arg Tyr Thr Gly Val Pro Ser Arg 
    50                  55                  60                  


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 
65                  70                  75                  80  


Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Tyr Ile 
                85                  90                  95      


Tyr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr 
            100                 105                 110         


Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu 
        115                 120                 125             


Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro 
    130                 135                 140                 


Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly 
145                 150                 155                 160 


Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr 
                165                 170                 175     


Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His 
            180                 185                 190         


Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val 
        195                 200                 205             


Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215         


<210>  37
<211>  260
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  heavy chain- His Tag-Beta9

<400>  37

Met Glu Ile Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
1               5                   10                  15      


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr 
            20                  25                  30          


Phe Thr Asp Tyr Thr Met Asp Trp Val Arg Gln Ala Pro Gly Lys Gly 
        35                  40                  45              


Leu Glu Trp Val Ala Asp Val Asn Pro Asn Ser Gly Gly Ser Ile Tyr 
    50                  55                  60                  


Asn Gln Arg Phe Lys Gly Arg Phe Thr Leu Ser Val Asp Arg Ser Lys 
65                  70                  75                  80  


Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala 
                85                  90                  95      


Val Tyr Tyr Cys Ala Arg Asn Leu Gly Pro Ser Phe Tyr Phe Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly 
        115                 120                 125             


Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly 
    130                 135                 140                 


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
145                 150                 155                 160 


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
                165                 170                 175     


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
            180                 185                 190         


Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val 
        195                 200                 205             


Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys 
    210                 215                 220                 


Ser Cys Asp Lys Thr His Thr Gly Gly Gly Ser Gly His His His His 
225                 230                 235                 240 


His His His His Gly Gly Gly Ser Gly Gly Ser Met Leu Phe Arg Val 
                245                 250                 255     


Thr Ile Asn Ser 
            260 


<210>  38
<211>  1552
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PertH-Beta10*

<400>  38
atggcaagcg atattcagat gacccagagc ccgagcagcc tgagcgcaag cgttggtgat       60

cgtgttacca ttacctgtaa ggcaagccag gatgttagca ttggtgttgc atggtatcag      120

cagaaaccgg gtaaagcacc gaaactgctg atttatagcg caagctatcg ttataccggt      180

gttccgagcc gttttagcgg tagcggcagc ggcaccgatt ttaccctgac cattagcagc      240

ctgcagccgg aagattttgc aacctattat tgtcagcagt actacatcta tccgtacacc      300

tttggtcagg gcaccaaagt tgaaattaaa cgtaccgttg cagcaccgag cgtttttatc      360

tttccgccta gcgatgagca gctgaaaagc ggtacagcca gcgttgtttg tctgctgaat      420

aacttttatc cgcgtgaagc aaaagttcag tggaaagttg ataatgcact gcagagcggt      480

aatagccaag aaagcgttac cgaacaggat agcaaagata gcacctatag cctgagcagc      540

accctgaccc tgagcaaagc agattatgaa aaacacaaag tgtatgcctg cgaagttacc      600

catcagggtc tgagcagtcc ggttaccaaa agctttaatc gtggtgaatg ttaattaact      660

cgaggctgag caaagcagac tactaataac ataaagtcta cgccggacgc atcgtggccc      720

tagtacgcaa gttcacgtaa aaagggtaac tagaggttga ggtgatttta tggaaattag      780

cgaagttcag ctggttgaaa gcggtggtgg tctggttcag cctggtggta gcctgcgtct      840

gagctgtgca gcaagcggtt ttacctttac cgattacacc atggattggg ttcgtcaggc      900

accgggtaaa ggtctggaat gggttgcaga tgttaatccg aatagcggtg gtagcattta      960

taaccagcgt tttaaaggtc gttttaccct gagcgttgat cgtagcaaaa ataccctgta     1020

tctgcaaatg aatagtctgc gtgcagagga taccgcagtg tattattgtg cacgtaatct     1080

gggtccgagc ttctattttg attattgggg tcagggcacc ctggttaccg ttagcagcgc     1140

aagcaccaaa ggtccgagcg tttttccgct ggcaccgagc agcaaaagca ccagcggtgg     1200

caccgcagca ctgggttgtc tggttaaaga ttattttccg gaaccggtta ccgtgagctg     1260

gaatagcggt gcactgacca gtggtgttca tacctttccg gcagttctgc agagcagcgg     1320

tctgtatagt ctgagcagcg ttgttaccgt tccgagcagt agcctgggca cccagaccta     1380

tatttgtaat gttaatcata aaccgagcaa caccaaagtg gataaaaaag ttgaaccgaa     1440

aagctgcgat aaaacccata ccggtggtgg tagcggtcat catcaccacc atcaccatca     1500

tggtggtggc agtggtgtga gcggttggcg tctgttcaaa aaaatcagct aa             1552


<210>  39
<211>  217
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  light chain

<400>  39

Met Ala Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
1               5                   10                  15      


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Val 
            20                  25                  30          


Ser Ile Gly Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys 
        35                  40                  45              


Leu Leu Ile Tyr Ser Ala Ser Tyr Arg Tyr Thr Gly Val Pro Ser Arg 
    50                  55                  60                  


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 
65                  70                  75                  80  


Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Tyr Ile 
                85                  90                  95      


Tyr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr 
            100                 105                 110         


Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu 
        115                 120                 125             


Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro 
    130                 135                 140                 


Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly 
145                 150                 155                 160 


Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr 
                165                 170                 175     


Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His 
            180                 185                 190         


Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val 
        195                 200                 205             


Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215         


<210>  40
<211>  260
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  heavy chain-His Tag-Beta10*

<400>  40

Met Glu Ile Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
1               5                   10                  15      


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr 
            20                  25                  30          


Phe Thr Asp Tyr Thr Met Asp Trp Val Arg Gln Ala Pro Gly Lys Gly 
        35                  40                  45              


Leu Glu Trp Val Ala Asp Val Asn Pro Asn Ser Gly Gly Ser Ile Tyr 
    50                  55                  60                  


Asn Gln Arg Phe Lys Gly Arg Phe Thr Leu Ser Val Asp Arg Ser Lys 
65                  70                  75                  80  


Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala 
                85                  90                  95      


Val Tyr Tyr Cys Ala Arg Asn Leu Gly Pro Ser Phe Tyr Phe Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly 
        115                 120                 125             


Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly 
    130                 135                 140                 


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
145                 150                 155                 160 


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
                165                 170                 175     


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
            180                 185                 190         


Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val 
        195                 200                 205             


Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys 
    210                 215                 220                 


Ser Cys Asp Lys Thr His Thr Gly Gly Gly Ser Gly His His His His 
225                 230                 235                 240 


His His His His Gly Gly Gly Ser Gly Val Ser Gly Trp Arg Leu Phe 
                245                 250                 255     


Lys Lys Ile Ser 
            260 


<210>  41
<211>  465
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Beta9-G3

<400>  41
atgggtagta tgctgtttcg tgttaccatt aacagcggtg gtggtagcgg tcatcatcac       60

caccatcacc atcatggtgg tggcagtggt gatctgggta aaaaactgct ggaagcagca      120

cgtgcaggtc aggatgatga agttcgtatt ctgatggcaa atggtgcaga tgttaatgcc      180

aaagatgaat atggtctgac accgctgtat ctggcaaccg cacatggtca tctggaaatt      240

gttgaagttc tgctgaaaaa cggtgccgat gtgaatgcag ttgatgcaat tggttttact      300

cctctgcatc tggcagcatt tattggccac ctggaaatcg ccgaggtgct gctgaaacat      360

ggtgcggacg ttaacgcaca ggataaattt ggtaaaaccg cctttgatat tagcattggc      420

aatggcaatg aagatctggc agaaatcctg cagaaactga actaa                      465


<210>  42
<211>  154
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Beta9-His Tag-G3

<400>  42

Met Gly Ser Met Leu Phe Arg Val Thr Ile Asn Ser Gly Gly Gly Ser 
1               5                   10                  15      


Gly His His His His His His His His Gly Gly Gly Ser Gly Asp Leu 
            20                  25                  30          


Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp Glu Val 
        35                  40                  45              


Arg Ile Leu Met Ala Asn Gly Ala Asp Val Asn Ala Lys Asp Glu Tyr 
    50                  55                  60                  


Gly Leu Thr Pro Leu Tyr Leu Ala Thr Ala His Gly His Leu Glu Ile 
65                  70                  75                  80  


Val Glu Val Leu Leu Lys Asn Gly Ala Asp Val Asn Ala Val Asp Ala 
                85                  90                  95      


Ile Gly Phe Thr Pro Leu His Leu Ala Ala Phe Ile Gly His Leu Glu 
            100                 105                 110         


Ile Ala Glu Val Leu Leu Lys His Gly Ala Asp Val Asn Ala Gln Asp 
        115                 120                 125             


Lys Phe Gly Lys Thr Ala Phe Asp Ile Ser Ile Gly Asn Gly Asn Glu 
    130                 135                 140                 


Asp Leu Ala Glu Ile Leu Gln Lys Leu Asn 
145                 150                 


<210>  43
<211>  465
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Beta10*-G3

<400>  43
atggtgagcg gttggcgtct gttcaaaaaa atcagcggtg gtggtagcgg tcatcatcac       60

caccatcacc atcatggtgg tggcagtggt gatctgggta aaaaactgct ggaagcagca      120

cgtgcaggtc aggatgatga agttcgtatt ctgatggcaa atggtgcaga tgttaatgcc      180

aaagatgaat atggtctgac accgctgtat ctggcaaccg cacatggtca tctggaaatt      240

gttgaagttc tgctgaaaaa cggtgccgat gtgaatgcag ttgatgcaat tggttttact      300

cctctgcatc tggcagcatt tattggccac ctggaaatcg ccgaggtgct gctgaaacat      360

ggtgcggacg ttaacgcaca ggataaattt ggtaaaaccg cctttgatat tagcattggc      420

aatggcaatg aagatctggc agaaatcctg cagaaactga actaa                      465


<210>  44
<211>  154
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Beta10*-His Tag-G3

<400>  44

Met Val Ser Gly Trp Arg Leu Phe Lys Lys Ile Ser Gly Gly Gly Ser 
1               5                   10                  15      


Gly His His His His His His His His Gly Gly Gly Ser Gly Asp Leu 
            20                  25                  30          


Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp Glu Val 
        35                  40                  45              


Arg Ile Leu Met Ala Asn Gly Ala Asp Val Asn Ala Lys Asp Glu Tyr 
    50                  55                  60                  


Gly Leu Thr Pro Leu Tyr Leu Ala Thr Ala His Gly His Leu Glu Ile 
65                  70                  75                  80  


Val Glu Val Leu Leu Lys Asn Gly Ala Asp Val Asn Ala Val Asp Ala 
                85                  90                  95      


Ile Gly Phe Thr Pro Leu His Leu Ala Ala Phe Ile Gly His Leu Glu 
            100                 105                 110         


Ile Ala Glu Val Leu Leu Lys His Gly Ala Asp Val Asn Ala Gln Asp 
        115                 120                 125             


Lys Phe Gly Lys Thr Ala Phe Asp Ile Ser Ile Gly Asn Gly Asn Glu 
    130                 135                 140                 


Asp Leu Ala Glu Ile Leu Gln Lys Leu Asn 
145                 150                 


<210>  45
<211>  489
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  G3-Beta9

<400>  45
atgcgtggta gccatcatca tcaccatcat ggtagcgatc tgggtaaaaa actgctggaa       60

gcagcacgtg caggtcagga tgatgaagtt cgtattctga tggcaaatgg tgcagatgtt      120

aatgccaaag atgaatatgg tctgacaccg ctgtatctgg caaccgcaca tggtcatctg      180

gaaattgttg aagttctgct gaaaaacggt gccgatgtga atgcagttga tgcaattggt      240

tttactcctc tgcatctggc agcatttatt ggccacctgg aaatcgccga ggtgctgctg      300

aaacatggtg cggacgttaa cgcacaggat aaatttggta aaaccgcctt tgatattagc      360

attggcaatg gcaatgaaga tctggcagaa atcctgcaga aactgaacgg tggtggtagc      420

ggtggtggtg gctcaggtgg cggtggttct ggtggtagta tgctgtttcg tgttaccatt      480

aacagctaa                                                              489


<210>  46
<211>  162
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  His Tag-G3-Beta9

<400>  46

Met Arg Gly Ser His His His His His His Gly Ser Asp Leu Gly Lys 
1               5                   10                  15      


Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp Glu Val Arg Ile 
            20                  25                  30          


Leu Met Ala Asn Gly Ala Asp Val Asn Ala Lys Asp Glu Tyr Gly Leu 
        35                  40                  45              


Thr Pro Leu Tyr Leu Ala Thr Ala His Gly His Leu Glu Ile Val Glu 
    50                  55                  60                  


Val Leu Leu Lys Asn Gly Ala Asp Val Asn Ala Val Asp Ala Ile Gly 
65                  70                  75                  80  


Phe Thr Pro Leu His Leu Ala Ala Phe Ile Gly His Leu Glu Ile Ala 
                85                  90                  95      


Glu Val Leu Leu Lys His Gly Ala Asp Val Asn Ala Gln Asp Lys Phe 
            100                 105                 110         


Gly Lys Thr Ala Phe Asp Ile Ser Ile Gly Asn Gly Asn Glu Asp Leu 
        115                 120                 125             


Ala Glu Ile Leu Gln Lys Leu Asn Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Ser Met Leu Phe Arg Val Thr Ile 
145                 150                 155                 160 


Asn Ser 
        


<210>  47
<211>  489
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  G3-Beta10*

<400>  47
atgcgtggta gccatcatca tcaccatcat ggtagcgatc tgggtaaaaa actgctggaa       60

gcagcacgtg caggtcagga tgatgaagtt cgtattctga tggcaaatgg tgcagatgtt      120

aatgccaaag atgaatatgg tctgacaccg ctgtatctgg caaccgcaca tggtcatctg      180

gaaattgttg aagttctgct gaaaaacggt gccgatgtga atgcagttga tgcaattggt      240

tttactcctc tgcatctggc agcatttatt ggccacctgg aaatcgccga ggtgctgctg      300

aaacatggtg cggacgttaa cgcacaggat aaatttggta aaaccgcctt tgatattagc      360

attggcaatg gcaatgaaga tctggcagaa atcctgcaga aactgaacgg tggtggtagc      420

ggtggtggtg gctcaggtgg cggtggttct ggtgtgagcg gttggcgtct gttcaaaaaa      480

atcagctaa                                                              489


<210>  48
<211>  162
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  His Tag-G3-Beta10*

<400>  48

Met Arg Gly Ser His His His His His His Gly Ser Asp Leu Gly Lys 
1               5                   10                  15      


Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp Glu Val Arg Ile 
            20                  25                  30          


Leu Met Ala Asn Gly Ala Asp Val Asn Ala Lys Asp Glu Tyr Gly Leu 
        35                  40                  45              


Thr Pro Leu Tyr Leu Ala Thr Ala His Gly His Leu Glu Ile Val Glu 
    50                  55                  60                  


Val Leu Leu Lys Asn Gly Ala Asp Val Asn Ala Val Asp Ala Ile Gly 
65                  70                  75                  80  


Phe Thr Pro Leu His Leu Ala Ala Phe Ile Gly His Leu Glu Ile Ala 
                85                  90                  95      


Glu Val Leu Leu Lys His Gly Ala Asp Val Asn Ala Gln Asp Lys Phe 
            100                 105                 110         


Gly Lys Thr Ala Phe Asp Ile Ser Ile Gly Asn Gly Asn Glu Asp Leu 
        115                 120                 125             


Ala Glu Ile Leu Gln Lys Leu Asn Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Val Ser Gly Trp Arg Leu Phe Lys Lys 
145                 150                 155                 160 


Ile Ser 
        


<210>  49
<211>  567
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Beta9-9.29

<400>  49
atgggtagta tgctgtttcg tgttaccatt aacagcggtg gtggtagcgg tcatcatcac       60

caccatcacc atcatggtgg tggcagtggt ggtagcgatc tgggtaaaaa actgctggaa      120

gcagcacgtg caggtcagga tgatgaagtt cgtattctga tggcaaatgg tgcagatgtt      180

aatgcccatg atttttatgg tattacaccg ctgcatctgg cagcaaattt tggtcatctg      240

gaaattgttg aagtgctgct gaaacatggt gccgatgtga acgcatttga ttatgataat      300

acccctctgc acctggctgc agatgctggc cacctggaaa tcgtagaggt tctgctgaaa      360

tacggtgcgg acgttaatgc aagcgatcgt gatggtcata ccccactgca tctggcagcc      420

cgtgaaggcc atctggaaat cgtggaagta ctgctgaaaa atggcgcaga cgtgaatgca      480

caggataaat ttggtaaaac cccgtttgat ctggccattg ataatggcaa tgaagatatt      540

gccgaggtgc tgcagaaagc agcataa                                          567


<210>  50
<211>  188
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Beta9-His Tag-9.29

<400>  50

Met Gly Ser Met Leu Phe Arg Val Thr Ile Asn Ser Gly Gly Gly Ser 
1               5                   10                  15      


Gly His His His His His His His His Gly Gly Gly Ser Gly Gly Ser 
            20                  25                  30          


Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp 
        35                  40                  45              


Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val Asn Ala His Asp 
    50                  55                  60                  


Phe Tyr Gly Ile Thr Pro Leu His Leu Ala Ala Asn Phe Gly His Leu 
65                  70                  75                  80  


Glu Ile Val Glu Val Leu Leu Lys His Gly Ala Asp Val Asn Ala Phe 
                85                  90                  95      


Asp Tyr Asp Asn Thr Pro Leu His Leu Ala Ala Asp Ala Gly His Leu 
            100                 105                 110         


Glu Ile Val Glu Val Leu Leu Lys Tyr Gly Ala Asp Val Asn Ala Ser 
        115                 120                 125             


Asp Arg Asp Gly His Thr Pro Leu His Leu Ala Ala Arg Glu Gly His 
    130                 135                 140                 


Leu Glu Ile Val Glu Val Leu Leu Lys Asn Gly Ala Asp Val Asn Ala 
145                 150                 155                 160 


Gln Asp Lys Phe Gly Lys Thr Pro Phe Asp Leu Ala Ile Asp Asn Gly 
                165                 170                 175     


Asn Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala 
            180                 185             


<210>  51
<211>  567
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Beta10*-9.29

<400>  51
atggtgagcg gttggcgtct gttcaaaaaa atcagcggtg gtggtagcgg tcatcatcac       60

caccatcacc atcatggtgg tggcagtggt ggtagcgatc tgggtaaaaa actgctggaa      120

gcagcacgtg caggtcagga tgatgaagtt cgtattctga tggcaaatgg tgcagatgtt      180

aatgcccatg atttttatgg tattacaccg ctgcatctgg cagcaaattt tggtcatctg      240

gaaattgttg aagtgctgct gaaacatggt gccgatgtga acgcatttga ttatgataat      300

acccctctgc acctggctgc agatgctggc cacctggaaa tcgtagaggt tctgctgaaa      360

tacggtgcgg acgttaatgc aagcgatcgt gatggtcata ccccactgca tctggcagcc      420

cgtgaaggcc atctggaaat cgtggaagta ctgctgaaaa atggcgcaga cgtgaatgca      480

caggataaat ttggtaaaac cccgtttgat ctggccattg ataatggcaa tgaagatatt      540

gccgaggtgc tgcagaaagc agcataa                                          567


<210>  52
<211>  188
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Beta10*-His Tag-9.29

<400>  52

Met Val Ser Gly Trp Arg Leu Phe Lys Lys Ile Ser Gly Gly Gly Ser 
1               5                   10                  15      


Gly His His His His His His His His Gly Gly Gly Ser Gly Gly Ser 
            20                  25                  30          


Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp 
        35                  40                  45              


Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val Asn Ala His Asp 
    50                  55                  60                  


Phe Tyr Gly Ile Thr Pro Leu His Leu Ala Ala Asn Phe Gly His Leu 
65                  70                  75                  80  


Glu Ile Val Glu Val Leu Leu Lys His Gly Ala Asp Val Asn Ala Phe 
                85                  90                  95      


Asp Tyr Asp Asn Thr Pro Leu His Leu Ala Ala Asp Ala Gly His Leu 
            100                 105                 110         


Glu Ile Val Glu Val Leu Leu Lys Tyr Gly Ala Asp Val Asn Ala Ser 
        115                 120                 125             


Asp Arg Asp Gly His Thr Pro Leu His Leu Ala Ala Arg Glu Gly His 
    130                 135                 140                 


Leu Glu Ile Val Glu Val Leu Leu Lys Asn Gly Ala Asp Val Asn Ala 
145                 150                 155                 160 


Gln Asp Lys Phe Gly Lys Thr Pro Phe Asp Leu Ala Ile Asp Asn Gly 
                165                 170                 175     


Asn Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala 
            180                 185             


<210>  53
<211>  567
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  9.29-Beta9

<400>  53
atgggtagcg atctgggtaa aaaactgctg gaagcagcac gtgcaggtca ggatgatgaa       60

gttcgtattc tgatggcaaa tggtgcagat gttaatgccc atgattttta tggtattaca      120

ccgctgcatc tggcagcaaa ttttggtcat ctggaaattg ttgaagtgct gctgaaacat      180

ggtgccgatg tgaacgcatt tgattatgat aatacccctc tgcacctggc tgcagatgct      240

ggccacctgg aaatcgtaga ggttctgctg aaatacggtg cggacgttaa tgcaagcgat      300

cgtgatggtc ataccccact gcatctggca gcccgtgaag gccatctgga aatcgtggaa      360

gtactgctga aaaatggcgc agacgtgaat gcacaggata aatttggtaa aaccccgttt      420

gatctggcca ttgataatgg caatgaagat attgccgagg tgctgcagaa agcagcaggt      480

ggtggtagcg gtcatcatca ccaccatcac catcatggtg gtggcagtgg tggtagtatg      540

ctgtttcgtg ttaccattaa cagctaa                                          567


<210>  54
<211>  188
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  9.29-His Tag-Beta9

<400>  54

Met Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly 
1               5                   10                  15      


Gln Asp Asp Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val Asn 
            20                  25                  30          


Ala His Asp Phe Tyr Gly Ile Thr Pro Leu His Leu Ala Ala Asn Phe 
        35                  40                  45              


Gly His Leu Glu Ile Val Glu Val Leu Leu Lys His Gly Ala Asp Val 
    50                  55                  60                  


Asn Ala Phe Asp Tyr Asp Asn Thr Pro Leu His Leu Ala Ala Asp Ala 
65                  70                  75                  80  


Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Tyr Gly Ala Asp Val 
                85                  90                  95      


Asn Ala Ser Asp Arg Asp Gly His Thr Pro Leu His Leu Ala Ala Arg 
            100                 105                 110         


Glu Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Asn Gly Ala Asp 
        115                 120                 125             


Val Asn Ala Gln Asp Lys Phe Gly Lys Thr Pro Phe Asp Leu Ala Ile 
    130                 135                 140                 


Asp Asn Gly Asn Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala Gly 
145                 150                 155                 160 


Gly Gly Ser Gly His His His His His His His His Gly Gly Gly Ser 
                165                 170                 175     


Gly Gly Ser Met Leu Phe Arg Val Thr Ile Asn Ser 
            180                 185             


<210>  55
<211>  567
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  9.29-Beta10*

<400>  55
atgggtagcg atctgggtaa aaaactgctg gaagcagcac gtgcaggtca ggatgatgaa       60

gttcgtattc tgatggcaaa tggtgcagat gttaatgccc atgattttta tggtattaca      120

ccgctgcatc tggcagcaaa ttttggtcat ctggaaattg ttgaagtgct gctgaaacat      180

ggtgccgatg tgaacgcatt tgattatgat aatacccctc tgcacctggc tgcagatgct      240

ggccacctgg aaatcgtaga ggttctgctg aaatacggtg cggacgttaa tgcaagcgat      300

cgtgatggtc ataccccact gcatctggca gcccgtgaag gccatctgga aatcgtggaa      360

gtactgctga aaaatggcgc agacgtgaat gcacaggata aatttggtaa aaccccgttt      420

gatctggcca ttgataatgg caatgaagat attgccgagg tgctgcagaa agcagcaggt      480

ggtggtagcg gtcatcatca ccaccatcac catcatggtg gtggcagtgg tgtgagcggt      540

tggcgtctgt tcaaaaaaat cagctaa                                          567


<210>  56
<211>  188
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  9.29-His Tag-Beta10*

<400>  56

Met Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly 
1               5                   10                  15      


Gln Asp Asp Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val Asn 
            20                  25                  30          


Ala His Asp Phe Tyr Gly Ile Thr Pro Leu His Leu Ala Ala Asn Phe 
        35                  40                  45              


Gly His Leu Glu Ile Val Glu Val Leu Leu Lys His Gly Ala Asp Val 
    50                  55                  60                  


Asn Ala Phe Asp Tyr Asp Asn Thr Pro Leu His Leu Ala Ala Asp Ala 
65                  70                  75                  80  


Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Tyr Gly Ala Asp Val 
                85                  90                  95      


Asn Ala Ser Asp Arg Asp Gly His Thr Pro Leu His Leu Ala Ala Arg 
            100                 105                 110         


Glu Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Asn Gly Ala Asp 
        115                 120                 125             


Val Asn Ala Gln Asp Lys Phe Gly Lys Thr Pro Phe Asp Leu Ala Ile 
    130                 135                 140                 


Asp Asn Gly Asn Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala Gly 
145                 150                 155                 160 


Gly Gly Ser Gly His His His His His His His His Gly Gly Gly Ser 
                165                 170                 175     


Gly Val Ser Gly Trp Arg Leu Phe Lys Lys Ile Ser 
            180                 185             


<210>  57
<211>  1479
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HT-Beta9-TNF

<400>  57
atgaaacatc atcaccatca ccacgcagaa atcggtactg gctttccatt cgacccccat       60

tatgtggaag tcctgggcga gcgcatgcac tacgtcgatg ttggtccgcg cgatggcacc      120

cctgtgctgt tcctgcacgg taacccgacc tcctcctacg tgtggcgcaa catcatcccg      180

catgttgcac cgacccatcg ctgcattgct ccagacctga tcggtatggg caaatccgac      240

aaaccagacc tgggttattt cttcgacgac cacgtccgct tcatggatgc cttcatcgaa      300

gccctgggtc tggaagaggt cgtcctggtc attcacgact ggggctccgc tctgggtttc      360

cactgggcca agcgcaatcc agagcgcgtc aaaggtattg catttatgga gttcatccgc      420

cctatcccga cctgggacga atggccagaa tttgcccgcg agaccttcca ggccttccgc      480

accaccgacg tcggccgcaa gctgatcatc gatcagaacg tttttatcga gggtacgctg      540

ccgatgggtg tcgtccgccc gctgactgaa gtcgagatgg accattaccg cgagccgttc      600

ctgaatcctg ttgaccgcga gccactgtgg cgcttcccaa acgagctgcc aatcgccggt      660

gagccagcga acatcgtcgc gctggtcgaa gaatacatgg actggctgca ccagtcccct      720

gtcccgaagc tgctgttctg gggcacccca ggcgttctga tcccaccggc cgaagccgct      780

cgcctggcca aaagcctgcc taactgcaag gctgtggaca tcggcccggg tctgaatctg      840

ctgcaagaag acaacccgga cctgatcggc agcgagatcg cgcgctggct gtcgacgctc      900

gagatttccg gcgagccaac cactgaggat ctgtactttc agggtagtat gctgtttcgt      960

gttaccatta acagcggtgg tggtagcggt ggtggtggca gtggtgttcg tagcagcagt     1020

cgtaccccga gcgataaacc ggttgcacat gttgttgcaa atccgcaggc cgaaggtcag     1080

ctgcagtggc tgaatcgtcg tgcaaatgca ctgctggcaa atggtgttga actgcgtgat     1140

aatcagctgg ttgttccgag cgaaggtctg tatctgattt atagccaggt tctgtttaaa     1200

ggtcagggtt gtccgagcac acatgttctg ctgacccata ccattagccg tattgcagtt     1260

agctatcaga ccaaagttaa tctgctgagc gcaattaaaa gcccgtgtca gcgtgaaaca     1320

ccggaaggtg ccgaagcaaa accgtggtat gaaccgattt atcttggtgg tgtttttcag     1380

ctggaaaagg gtgatcgtct gagcgcagaa attaatcgtc cggattatct ggattttgca     1440

gaaagcggtc aggtgtattt tggcattatt gcattataa                            1479


<210>  58
<211>  492
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HT-Beta9-TNF

<400>  58

Met Lys His His His His His His Ala Glu Ile Gly Thr Gly Phe Pro 
1               5                   10                  15      


Phe Asp Pro His Tyr Val Glu Val Leu Gly Glu Arg Met His Tyr Val 
            20                  25                  30          


Asp Val Gly Pro Arg Asp Gly Thr Pro Val Leu Phe Leu His Gly Asn 
        35                  40                  45              


Pro Thr Ser Ser Tyr Val Trp Arg Asn Ile Ile Pro His Val Ala Pro 
    50                  55                  60                  


Thr His Arg Cys Ile Ala Pro Asp Leu Ile Gly Met Gly Lys Ser Asp 
65                  70                  75                  80  


Lys Pro Asp Leu Gly Tyr Phe Phe Asp Asp His Val Arg Phe Met Asp 
                85                  90                  95      


Ala Phe Ile Glu Ala Leu Gly Leu Glu Glu Val Val Leu Val Ile His 
            100                 105                 110         


Asp Trp Gly Ser Ala Leu Gly Phe His Trp Ala Lys Arg Asn Pro Glu 
        115                 120                 125             


Arg Val Lys Gly Ile Ala Phe Met Glu Phe Ile Arg Pro Ile Pro Thr 
    130                 135                 140                 


Trp Asp Glu Trp Pro Glu Phe Ala Arg Glu Thr Phe Gln Ala Phe Arg 
145                 150                 155                 160 


Thr Thr Asp Val Gly Arg Lys Leu Ile Ile Asp Gln Asn Val Phe Ile 
                165                 170                 175     


Glu Gly Thr Leu Pro Met Gly Val Val Arg Pro Leu Thr Glu Val Glu 
            180                 185                 190         


Met Asp His Tyr Arg Glu Pro Phe Leu Asn Pro Val Asp Arg Glu Pro 
        195                 200                 205             


Leu Trp Arg Phe Pro Asn Glu Leu Pro Ile Ala Gly Glu Pro Ala Asn 
    210                 215                 220                 


Ile Val Ala Leu Val Glu Glu Tyr Met Asp Trp Leu His Gln Ser Pro 
225                 230                 235                 240 


Val Pro Lys Leu Leu Phe Trp Gly Thr Pro Gly Val Leu Ile Pro Pro 
                245                 250                 255     


Ala Glu Ala Ala Arg Leu Ala Lys Ser Leu Pro Asn Cys Lys Ala Val 
            260                 265                 270         


Asp Ile Gly Pro Gly Leu Asn Leu Leu Gln Glu Asp Asn Pro Asp Leu 
        275                 280                 285             


Ile Gly Ser Glu Ile Ala Arg Trp Leu Ser Thr Leu Glu Ile Ser Gly 
    290                 295                 300                 


Glu Pro Thr Thr Glu Asp Leu Tyr Phe Gln Gly Ser Met Leu Phe Arg 
305                 310                 315                 320 


Val Thr Ile Asn Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Val 
                325                 330                 335     


Arg Ser Ser Ser Arg Thr Pro Ser Asp Lys Pro Val Ala His Val Val 
            340                 345                 350         


Ala Asn Pro Gln Ala Glu Gly Gln Leu Gln Trp Leu Asn Arg Arg Ala 
        355                 360                 365             


Asn Ala Leu Leu Ala Asn Gly Val Glu Leu Arg Asp Asn Gln Leu Val 
    370                 375                 380                 


Val Pro Ser Glu Gly Leu Tyr Leu Ile Tyr Ser Gln Val Leu Phe Lys 
385                 390                 395                 400 


Gly Gln Gly Cys Pro Ser Thr His Val Leu Leu Thr His Thr Ile Ser 
                405                 410                 415     


Arg Ile Ala Val Ser Tyr Gln Thr Lys Val Asn Leu Leu Ser Ala Ile 
            420                 425                 430         


Lys Ser Pro Cys Gln Arg Glu Thr Pro Glu Gly Ala Glu Ala Lys Pro 
        435                 440                 445             


Trp Tyr Glu Pro Ile Tyr Leu Gly Gly Val Phe Gln Leu Glu Lys Gly 
    450                 455                 460                 


Asp Arg Leu Ser Ala Glu Ile Asn Arg Pro Asp Tyr Leu Asp Phe Ala 
465                 470                 475                 480 


Glu Ser Gly Gln Val Tyr Phe Gly Ile Ile Ala Leu 
                485                 490         


<210>  59
<211>  1482
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HT-TNF-Beta9

<400>  59
atgaaacatc atcaccatca ccacgcagaa atcggtactg gctttccatt cgacccccat       60

tatgtggaag tcctgggcga gcgcatgcac tacgtcgatg ttggtccgcg cgatggcacc      120

cctgtgctgt tcctgcacgg taacccgacc tcctcctacg tgtggcgcaa catcatcccg      180

catgttgcac cgacccatcg ctgcattgct ccagacctga tcggtatggg caaatccgac      240

aaaccagacc tgggttattt cttcgacgac cacgtccgct tcatggatgc cttcatcgaa      300

gccctgggtc tggaagaggt cgtcctggtc attcacgact ggggctccgc tctgggtttc      360

cactgggcca agcgcaatcc agagcgcgtc aaaggtattg catttatgga gttcatccgc      420

cctatcccga cctgggacga atggccagaa tttgcccgcg agaccttcca ggccttccgc      480

accaccgacg tcggccgcaa gctgatcatc gatcagaacg tttttatcga gggtacgctg      540

ccgatgggtg tcgtccgccc gctgactgaa gtcgagatgg accattaccg cgagccgttc      600

ctgaatcctg ttgaccgcga gccactgtgg cgcttcccaa acgagctgcc aatcgccggt      660

gagccagcga acatcgtcgc gctggtcgaa gaatacatgg actggctgca ccagtcccct      720

gtcccgaagc tgctgttctg gggcacccca ggcgttctga tcccaccggc cgaagccgct      780

cgcctggcca aaagcctgcc taactgcaag gctgtggaca tcggcccggg tctgaatctg      840

ctgcaagaag acaacccgga cctgatcggc agcgagatcg cgcgctggct gtcgacgctc      900

gagatttccg gcgagccaac cactgaggat ctgtactttc agggtgttcg tagcagcagt      960

cgtaccccga gcgataaacc ggttgcacat gttgttgcaa atccgcaggc cgaaggtcag     1020

ctgcagtggc tgaatcgtcg tgcaaatgca ctgctggcaa atggtgttga actgcgtgat     1080

aatcagctgg ttgttccgag cgaaggtctg tatctgattt atagccaggt tctgtttaaa     1140

ggtcagggtt gtccgagcac acatgttctg ctgacccata ccattagccg tattgcagtt     1200

agctatcaga ccaaagttaa tctgctgagc gcaattaaaa gcccgtgtca gcgtgaaaca     1260

ccggaaggtg ccgaagcaaa accgtggtat gaaccgattt atcttggtgg tgtttttcag     1320

ctggaaaagg gtgatcgtct gagcgcagaa attaatcgtc cggattatct ggattttgca     1380

gaaagcggtc aggtgtattt tggcattatt gcattaggcg gtggttcagg tggtggcggt     1440

tctggtggta gtatgctgtt tcgtgttacc attaacagct aa                        1482


<210>  60
<211>  493
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HT-TNF-Beta9

<400>  60

Met Lys His His His His His His Ala Glu Ile Gly Thr Gly Phe Pro 
1               5                   10                  15      


Phe Asp Pro His Tyr Val Glu Val Leu Gly Glu Arg Met His Tyr Val 
            20                  25                  30          


Asp Val Gly Pro Arg Asp Gly Thr Pro Val Leu Phe Leu His Gly Asn 
        35                  40                  45              


Pro Thr Ser Ser Tyr Val Trp Arg Asn Ile Ile Pro His Val Ala Pro 
    50                  55                  60                  


Thr His Arg Cys Ile Ala Pro Asp Leu Ile Gly Met Gly Lys Ser Asp 
65                  70                  75                  80  


Lys Pro Asp Leu Gly Tyr Phe Phe Asp Asp His Val Arg Phe Met Asp 
                85                  90                  95      


Ala Phe Ile Glu Ala Leu Gly Leu Glu Glu Val Val Leu Val Ile His 
            100                 105                 110         


Asp Trp Gly Ser Ala Leu Gly Phe His Trp Ala Lys Arg Asn Pro Glu 
        115                 120                 125             


Arg Val Lys Gly Ile Ala Phe Met Glu Phe Ile Arg Pro Ile Pro Thr 
    130                 135                 140                 


Trp Asp Glu Trp Pro Glu Phe Ala Arg Glu Thr Phe Gln Ala Phe Arg 
145                 150                 155                 160 


Thr Thr Asp Val Gly Arg Lys Leu Ile Ile Asp Gln Asn Val Phe Ile 
                165                 170                 175     


Glu Gly Thr Leu Pro Met Gly Val Val Arg Pro Leu Thr Glu Val Glu 
            180                 185                 190         


Met Asp His Tyr Arg Glu Pro Phe Leu Asn Pro Val Asp Arg Glu Pro 
        195                 200                 205             


Leu Trp Arg Phe Pro Asn Glu Leu Pro Ile Ala Gly Glu Pro Ala Asn 
    210                 215                 220                 


Ile Val Ala Leu Val Glu Glu Tyr Met Asp Trp Leu His Gln Ser Pro 
225                 230                 235                 240 


Val Pro Lys Leu Leu Phe Trp Gly Thr Pro Gly Val Leu Ile Pro Pro 
                245                 250                 255     


Ala Glu Ala Ala Arg Leu Ala Lys Ser Leu Pro Asn Cys Lys Ala Val 
            260                 265                 270         


Asp Ile Gly Pro Gly Leu Asn Leu Leu Gln Glu Asp Asn Pro Asp Leu 
        275                 280                 285             


Ile Gly Ser Glu Ile Ala Arg Trp Leu Ser Thr Leu Glu Ile Ser Gly 
    290                 295                 300                 


Glu Pro Thr Thr Glu Asp Leu Tyr Phe Gln Gly Val Arg Ser Ser Ser 
305                 310                 315                 320 


Arg Thr Pro Ser Asp Lys Pro Val Ala His Val Val Ala Asn Pro Gln 
                325                 330                 335     


Ala Glu Gly Gln Leu Gln Trp Leu Asn Arg Arg Ala Asn Ala Leu Leu 
            340                 345                 350         


Ala Asn Gly Val Glu Leu Arg Asp Asn Gln Leu Val Val Pro Ser Glu 
        355                 360                 365             


Gly Leu Tyr Leu Ile Tyr Ser Gln Val Leu Phe Lys Gly Gln Gly Cys 
    370                 375                 380                 


Pro Ser Thr His Val Leu Leu Thr His Thr Ile Ser Arg Ile Ala Val 
385                 390                 395                 400 


Ser Tyr Gln Thr Lys Val Asn Leu Leu Ser Ala Ile Lys Ser Pro Cys 
                405                 410                 415     


Gln Arg Glu Thr Pro Glu Gly Ala Glu Ala Lys Pro Trp Tyr Glu Pro 
            420                 425                 430         


Ile Tyr Leu Gly Gly Val Phe Gln Leu Glu Lys Gly Asp Arg Leu Ser 
        435                 440                 445             


Ala Glu Ile Asn Arg Pro Asp Tyr Leu Asp Phe Ala Glu Ser Gly Gln 
    450                 455                 460                 


Val Tyr Phe Gly Ile Ile Ala Leu Gly Gly Gly Ser Gly Gly Gly Gly 
465                 470                 475                 480 


Ser Gly Gly Ser Met Leu Phe Arg Val Thr Ile Asn Ser 
                485                 490             


<210>  61
<211>  1482
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HT-Beta10*-TNF

<400>  61
atgaaacatc atcaccatca ccacgcagaa atcggtactg gctttccatt cgacccccat       60

tatgtggaag tcctgggcga gcgcatgcac tacgtcgatg ttggtccgcg cgatggcacc      120

cctgtgctgt tcctgcacgg taacccgacc tcctcctacg tgtggcgcaa catcatcccg      180

catgttgcac cgacccatcg ctgcattgct ccagacctga tcggtatggg caaatccgac      240

aaaccagacc tgggttattt cttcgacgac cacgtccgct tcatggatgc cttcatcgaa      300

gccctgggtc tggaagaggt cgtcctggtc attcacgact ggggctccgc tctgggtttc      360

cactgggcca agcgcaatcc agagcgcgtc aaaggtattg catttatgga gttcatccgc      420

cctatcccga cctgggacga atggccagaa tttgcccgcg agaccttcca ggccttccgc      480

accaccgacg tcggccgcaa gctgatcatc gatcagaacg tttttatcga gggtacgctg      540

ccgatgggtg tcgtccgccc gctgactgaa gtcgagatgg accattaccg cgagccgttc      600

ctgaatcctg ttgaccgcga gccactgtgg cgcttcccaa acgagctgcc aatcgccggt      660

gagccagcga acatcgtcgc gctggtcgaa gaatacatgg actggctgca ccagtcccct      720

gtcccgaagc tgctgttctg gggcacccca ggcgttctga tcccaccggc cgaagccgct      780

cgcctggcca aaagcctgcc taactgcaag gctgtggaca tcggcccggg tctgaatctg      840

ctgcaagaag acaacccgga cctgatcggc agcgagatcg cgcgctggct gtcgacgctc      900

gagatttccg gcgagccaac cactgaggat ctgtactttc agggtgtgag cggttggcgt      960

ctgttcaaaa aaatcagcgg tggtggtagc ggtggtggtg gcagtggtgt tcgtagcagc     1020

agtcgtaccc cgagcgataa accggttgca catgttgttg caaatccgca ggccgaaggt     1080

cagctgcagt ggctgaatcg tcgtgcaaat gcactgctgg caaatggtgt tgaactgcgt     1140

gataatcagc tggttgttcc gagcgaaggt ctgtatctga tttatagcca ggttctgttt     1200

aaaggtcagg gttgtccgag cacacatgtt ctgctgaccc ataccattag ccgtattgca     1260

gttagctatc agaccaaagt taatctgctg agcgcaatta aaagcccgtg tcagcgtgaa     1320

acaccggaag gtgccgaagc aaaaccgtgg tatgaaccga tttatcttgg tggtgttttt     1380

cagctggaaa agggtgatcg tctgagcgca gaaattaatc gtccggatta tctggatttt     1440

gcagaaagcg gtcaggtgta ttttggcatt attgcattat aa                        1482


<210>  62
<211>  493
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HT-Beta10*-TNF

<400>  62

Met Lys His His His His His His Ala Glu Ile Gly Thr Gly Phe Pro 
1               5                   10                  15      


Phe Asp Pro His Tyr Val Glu Val Leu Gly Glu Arg Met His Tyr Val 
            20                  25                  30          


Asp Val Gly Pro Arg Asp Gly Thr Pro Val Leu Phe Leu His Gly Asn 
        35                  40                  45              


Pro Thr Ser Ser Tyr Val Trp Arg Asn Ile Ile Pro His Val Ala Pro 
    50                  55                  60                  


Thr His Arg Cys Ile Ala Pro Asp Leu Ile Gly Met Gly Lys Ser Asp 
65                  70                  75                  80  


Lys Pro Asp Leu Gly Tyr Phe Phe Asp Asp His Val Arg Phe Met Asp 
                85                  90                  95      


Ala Phe Ile Glu Ala Leu Gly Leu Glu Glu Val Val Leu Val Ile His 
            100                 105                 110         


Asp Trp Gly Ser Ala Leu Gly Phe His Trp Ala Lys Arg Asn Pro Glu 
        115                 120                 125             


Arg Val Lys Gly Ile Ala Phe Met Glu Phe Ile Arg Pro Ile Pro Thr 
    130                 135                 140                 


Trp Asp Glu Trp Pro Glu Phe Ala Arg Glu Thr Phe Gln Ala Phe Arg 
145                 150                 155                 160 


Thr Thr Asp Val Gly Arg Lys Leu Ile Ile Asp Gln Asn Val Phe Ile 
                165                 170                 175     


Glu Gly Thr Leu Pro Met Gly Val Val Arg Pro Leu Thr Glu Val Glu 
            180                 185                 190         


Met Asp His Tyr Arg Glu Pro Phe Leu Asn Pro Val Asp Arg Glu Pro 
        195                 200                 205             


Leu Trp Arg Phe Pro Asn Glu Leu Pro Ile Ala Gly Glu Pro Ala Asn 
    210                 215                 220                 


Ile Val Ala Leu Val Glu Glu Tyr Met Asp Trp Leu His Gln Ser Pro 
225                 230                 235                 240 


Val Pro Lys Leu Leu Phe Trp Gly Thr Pro Gly Val Leu Ile Pro Pro 
                245                 250                 255     


Ala Glu Ala Ala Arg Leu Ala Lys Ser Leu Pro Asn Cys Lys Ala Val 
            260                 265                 270         


Asp Ile Gly Pro Gly Leu Asn Leu Leu Gln Glu Asp Asn Pro Asp Leu 
        275                 280                 285             


Ile Gly Ser Glu Ile Ala Arg Trp Leu Ser Thr Leu Glu Ile Ser Gly 
    290                 295                 300                 


Glu Pro Thr Thr Glu Asp Leu Tyr Phe Gln Gly Val Ser Gly Trp Arg 
305                 310                 315                 320 


Leu Phe Lys Lys Ile Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
                325                 330                 335     


Val Arg Ser Ser Ser Arg Thr Pro Ser Asp Lys Pro Val Ala His Val 
            340                 345                 350         


Val Ala Asn Pro Gln Ala Glu Gly Gln Leu Gln Trp Leu Asn Arg Arg 
        355                 360                 365             


Ala Asn Ala Leu Leu Ala Asn Gly Val Glu Leu Arg Asp Asn Gln Leu 
    370                 375                 380                 


Val Val Pro Ser Glu Gly Leu Tyr Leu Ile Tyr Ser Gln Val Leu Phe 
385                 390                 395                 400 


Lys Gly Gln Gly Cys Pro Ser Thr His Val Leu Leu Thr His Thr Ile 
                405                 410                 415     


Ser Arg Ile Ala Val Ser Tyr Gln Thr Lys Val Asn Leu Leu Ser Ala 
            420                 425                 430         


Ile Lys Ser Pro Cys Gln Arg Glu Thr Pro Glu Gly Ala Glu Ala Lys 
        435                 440                 445             


Pro Trp Tyr Glu Pro Ile Tyr Leu Gly Gly Val Phe Gln Leu Glu Lys 
    450                 455                 460                 


Gly Asp Arg Leu Ser Ala Glu Ile Asn Arg Pro Asp Tyr Leu Asp Phe 
465                 470                 475                 480 


Ala Glu Ser Gly Gln Val Tyr Phe Gly Ile Ile Ala Leu 
                485                 490             


<210>  63
<211>  1482
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HT-TNF-Beta10*

<400>  63
atgaaacatc atcaccatca ccacgcagaa atcggtactg gctttccatt cgacccccat       60

tatgtggaag tcctgggcga gcgcatgcac tacgtcgatg ttggtccgcg cgatggcacc      120

cctgtgctgt tcctgcacgg taacccgacc tcctcctacg tgtggcgcaa catcatcccg      180

catgttgcac cgacccatcg ctgcattgct ccagacctga tcggtatggg caaatccgac      240

aaaccagacc tgggttattt cttcgacgac cacgtccgct tcatggatgc cttcatcgaa      300

gccctgggtc tggaagaggt cgtcctggtc attcacgact ggggctccgc tctgggtttc      360

cactgggcca agcgcaatcc agagcgcgtc aaaggtattg catttatgga gttcatccgc      420

cctatcccga cctgggacga atggccagaa tttgcccgcg agaccttcca ggccttccgc      480

accaccgacg tcggccgcaa gctgatcatc gatcagaacg tttttatcga gggtacgctg      540

ccgatgggtg tcgtccgccc gctgactgaa gtcgagatgg accattaccg cgagccgttc      600

ctgaatcctg ttgaccgcga gccactgtgg cgcttcccaa acgagctgcc aatcgccggt      660

gagccagcga acatcgtcgc gctggtcgaa gaatacatgg actggctgca ccagtcccct      720

gtcccgaagc tgctgttctg gggcacccca ggcgttctga tcccaccggc cgaagccgct      780

cgcctggcca aaagcctgcc taactgcaag gctgtggaca tcggcccggg tctgaatctg      840

ctgcaagaag acaacccgga cctgatcggc agcgagatcg cgcgctggct gtcgacgctc      900

gagatttccg gcgagccaac cactgaggat ctgtactttc agggtgttcg tagcagcagt      960

cgtaccccga gcgataaacc ggttgcacat gttgttgcaa atccgcaggc cgaaggtcag     1020

ctgcagtggc tgaatcgtcg tgcaaatgca ctgctggcaa atggtgttga actgcgtgat     1080

aatcagctgg ttgttccgag cgaaggtctg tatctgattt atagccaggt tctgtttaaa     1140

ggtcagggtt gtccgagcac acatgttctg ctgacccata ccattagccg tattgcagtt     1200

agctatcaga ccaaagttaa tctgctgagc gcaattaaaa gcccgtgtca gcgtgaaaca     1260

ccggaaggtg ccgaagcaaa accgtggtat gaaccgattt atcttggtgg tgtttttcag     1320

ctggaaaagg gtgatcgtct gagcgcagaa attaatcgtc cggattatct ggattttgca     1380

gaaagcggtc aggtgtattt tggcattatt gcattaggcg gtggttcagg tggtggcggt     1440

tctggtgtta gcggttggcg tctgtttaaa aagattagct aa                        1482


<210>  64
<211>  493
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HT-TNF-Beta10*

<400>  64

Met Lys His His His His His His Ala Glu Ile Gly Thr Gly Phe Pro 
1               5                   10                  15      


Phe Asp Pro His Tyr Val Glu Val Leu Gly Glu Arg Met His Tyr Val 
            20                  25                  30          


Asp Val Gly Pro Arg Asp Gly Thr Pro Val Leu Phe Leu His Gly Asn 
        35                  40                  45              


Pro Thr Ser Ser Tyr Val Trp Arg Asn Ile Ile Pro His Val Ala Pro 
    50                  55                  60                  


Thr His Arg Cys Ile Ala Pro Asp Leu Ile Gly Met Gly Lys Ser Asp 
65                  70                  75                  80  


Lys Pro Asp Leu Gly Tyr Phe Phe Asp Asp His Val Arg Phe Met Asp 
                85                  90                  95      


Ala Phe Ile Glu Ala Leu Gly Leu Glu Glu Val Val Leu Val Ile His 
            100                 105                 110         


Asp Trp Gly Ser Ala Leu Gly Phe His Trp Ala Lys Arg Asn Pro Glu 
        115                 120                 125             


Arg Val Lys Gly Ile Ala Phe Met Glu Phe Ile Arg Pro Ile Pro Thr 
    130                 135                 140                 


Trp Asp Glu Trp Pro Glu Phe Ala Arg Glu Thr Phe Gln Ala Phe Arg 
145                 150                 155                 160 


Thr Thr Asp Val Gly Arg Lys Leu Ile Ile Asp Gln Asn Val Phe Ile 
                165                 170                 175     


Glu Gly Thr Leu Pro Met Gly Val Val Arg Pro Leu Thr Glu Val Glu 
            180                 185                 190         


Met Asp His Tyr Arg Glu Pro Phe Leu Asn Pro Val Asp Arg Glu Pro 
        195                 200                 205             


Leu Trp Arg Phe Pro Asn Glu Leu Pro Ile Ala Gly Glu Pro Ala Asn 
    210                 215                 220                 


Ile Val Ala Leu Val Glu Glu Tyr Met Asp Trp Leu His Gln Ser Pro 
225                 230                 235                 240 


Val Pro Lys Leu Leu Phe Trp Gly Thr Pro Gly Val Leu Ile Pro Pro 
                245                 250                 255     


Ala Glu Ala Ala Arg Leu Ala Lys Ser Leu Pro Asn Cys Lys Ala Val 
            260                 265                 270         


Asp Ile Gly Pro Gly Leu Asn Leu Leu Gln Glu Asp Asn Pro Asp Leu 
        275                 280                 285             


Ile Gly Ser Glu Ile Ala Arg Trp Leu Ser Thr Leu Glu Ile Ser Gly 
    290                 295                 300                 


Glu Pro Thr Thr Glu Asp Leu Tyr Phe Gln Gly Val Arg Ser Ser Ser 
305                 310                 315                 320 


Arg Thr Pro Ser Asp Lys Pro Val Ala His Val Val Ala Asn Pro Gln 
                325                 330                 335     


Ala Glu Gly Gln Leu Gln Trp Leu Asn Arg Arg Ala Asn Ala Leu Leu 
            340                 345                 350         


Ala Asn Gly Val Glu Leu Arg Asp Asn Gln Leu Val Val Pro Ser Glu 
        355                 360                 365             


Gly Leu Tyr Leu Ile Tyr Ser Gln Val Leu Phe Lys Gly Gln Gly Cys 
    370                 375                 380                 


Pro Ser Thr His Val Leu Leu Thr His Thr Ile Ser Arg Ile Ala Val 
385                 390                 395                 400 


Ser Tyr Gln Thr Lys Val Asn Leu Leu Ser Ala Ile Lys Ser Pro Cys 
                405                 410                 415     


Gln Arg Glu Thr Pro Glu Gly Ala Glu Ala Lys Pro Trp Tyr Glu Pro 
            420                 425                 430         


Ile Tyr Leu Gly Gly Val Phe Gln Leu Glu Lys Gly Asp Arg Leu Ser 
        435                 440                 445             


Ala Glu Ile Asn Arg Pro Asp Tyr Leu Asp Phe Ala Glu Ser Gly Gln 
    450                 455                 460                 


Val Tyr Phe Gly Ile Ile Ala Leu Gly Gly Gly Ser Gly Gly Gly Gly 
465                 470                 475                 480 


Ser Gly Val Ser Gly Trp Arg Leu Phe Lys Lys Ile Ser 
                485                 490             


<210>  65
<211>  564
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Beta9-TNF

<400>  65
atgggtagta tgctgtttcg tgttaccatt aacagcggtg gtggtagcgg tcatcatcac       60

caccatcacc atcatggtgg tggcagtggt gttcgtagca gcagtcgtac cccgagcgat      120

aaaccggttg cacatgttgt tgcaaatccg caggccgaag gtcagctgca gtggctgaat      180

cgtcgtgcaa atgcactgct ggcaaatggt gttgaactgc gtgataatca gctggttgtt      240

ccgagcgaag gtctgtatct gatttatagc caggttctgt ttaaaggtca gggttgtccg      300

agcacacatg ttctgctgac ccataccatt agccgtattg cagttagcta tcagaccaaa      360

gttaatctgc tgagcgcaat taaaagcccg tgtcagcgtg aaacaccgga aggtgccgaa      420

gcaaaaccgt ggtatgaacc gatttatctt ggtggtgttt ttcagctgga aaagggtgat      480

cgtctgagcg cagaaattaa tcgtccggat tatctggatt ttgcagaaag cggtcaggtg      540

tattttggca ttattgcatt ataa                                             564


<210>  66
<211>  187
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Beta9-TNF

<400>  66

Met Gly Ser Met Leu Phe Arg Val Thr Ile Asn Ser Gly Gly Gly Ser 
1               5                   10                  15      


Gly His His His His His His His His Gly Gly Gly Ser Gly Val Arg 
            20                  25                  30          


Ser Ser Ser Arg Thr Pro Ser Asp Lys Pro Val Ala His Val Val Ala 
        35                  40                  45              


Asn Pro Gln Ala Glu Gly Gln Leu Gln Trp Leu Asn Arg Arg Ala Asn 
    50                  55                  60                  


Ala Leu Leu Ala Asn Gly Val Glu Leu Arg Asp Asn Gln Leu Val Val 
65                  70                  75                  80  


Pro Ser Glu Gly Leu Tyr Leu Ile Tyr Ser Gln Val Leu Phe Lys Gly 
                85                  90                  95      


Gln Gly Cys Pro Ser Thr His Val Leu Leu Thr His Thr Ile Ser Arg 
            100                 105                 110         


Ile Ala Val Ser Tyr Gln Thr Lys Val Asn Leu Leu Ser Ala Ile Lys 
        115                 120                 125             


Ser Pro Cys Gln Arg Glu Thr Pro Glu Gly Ala Glu Ala Lys Pro Trp 
    130                 135                 140                 


Tyr Glu Pro Ile Tyr Leu Gly Gly Val Phe Gln Leu Glu Lys Gly Asp 
145                 150                 155                 160 


Arg Leu Ser Ala Glu Ile Asn Arg Pro Asp Tyr Leu Asp Phe Ala Glu 
                165                 170                 175     


Ser Gly Gln Val Tyr Phe Gly Ile Ile Ala Leu 
            180                 185         


<210>  67
<211>  564
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TNF-Beta9

<400>  67
atggttcgta gcagcagtcg taccccgagc gataaaccgg ttgcacatgt tgttgcaaat       60

ccgcaggccg aaggtcagct gcagtggctg aatcgtcgtg caaatgcact gctggcaaat      120

ggtgttgaac tgcgtgataa tcagctggtt gttccgagcg aaggtctgta tctgatttat      180

agccaggttc tgtttaaagg tcagggttgt ccgagcacac atgttctgct gacccatacc      240

attagccgta ttgcagttag ctatcagacc aaagttaatc tgctgagcgc aattaaaagc      300

ccgtgtcagc gtgaaacacc ggaaggtgcc gaagcaaaac cgtggtatga accgatttat      360

cttggtggtg tttttcagct ggaaaagggt gatcgtctga gcgcagaaat taatcgtccg      420

gattatctgg attttgcaga aagcggtcag gtgtattttg gcattattgc attaggtggt      480

ggtagcggtc atcatcacca ccatcaccat catggtggtg gcagtggtgg tagtatgctg      540

tttcgtgtta ccattaacag ctaa                                             564


<210>  68
<211>  187
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TNF-Beta9

<400>  68

Met Val Arg Ser Ser Ser Arg Thr Pro Ser Asp Lys Pro Val Ala His 
1               5                   10                  15      


Val Val Ala Asn Pro Gln Ala Glu Gly Gln Leu Gln Trp Leu Asn Arg 
            20                  25                  30          


Arg Ala Asn Ala Leu Leu Ala Asn Gly Val Glu Leu Arg Asp Asn Gln 
        35                  40                  45              


Leu Val Val Pro Ser Glu Gly Leu Tyr Leu Ile Tyr Ser Gln Val Leu 
    50                  55                  60                  


Phe Lys Gly Gln Gly Cys Pro Ser Thr His Val Leu Leu Thr His Thr 
65                  70                  75                  80  


Ile Ser Arg Ile Ala Val Ser Tyr Gln Thr Lys Val Asn Leu Leu Ser 
                85                  90                  95      


Ala Ile Lys Ser Pro Cys Gln Arg Glu Thr Pro Glu Gly Ala Glu Ala 
            100                 105                 110         


Lys Pro Trp Tyr Glu Pro Ile Tyr Leu Gly Gly Val Phe Gln Leu Glu 
        115                 120                 125             


Lys Gly Asp Arg Leu Ser Ala Glu Ile Asn Arg Pro Asp Tyr Leu Asp 
    130                 135                 140                 


Phe Ala Glu Ser Gly Gln Val Tyr Phe Gly Ile Ile Ala Leu Gly Gly 
145                 150                 155                 160 


Gly Ser Gly His His His His His His His His Gly Gly Gly Ser Gly 
                165                 170                 175     


Gly Ser Met Leu Phe Arg Val Thr Ile Asn Ser 
            180                 185         


<210>  69
<211>  564
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Beta10*-TNF

<400>  69
atggtgagcg gttggcgtct gttcaaaaaa atcagcggtg gtggtagcgg tcatcatcac       60

caccatcacc atcatggtgg tggcagtggt gttcgtagca gcagtcgtac cccgagcgat      120

aaaccggttg cacatgttgt tgcaaatccg caggccgaag gtcagctgca gtggctgaat      180

cgtcgtgcaa atgcactgct ggcaaatggt gttgaactgc gtgataatca gctggttgtt      240

ccgagcgaag gtctgtatct gatttatagc caggttctgt ttaaaggtca gggttgtccg      300

agcacacatg ttctgctgac ccataccatt agccgtattg cagttagcta tcagaccaaa      360

gttaatctgc tgagcgcaat taaaagcccg tgtcagcgtg aaacaccgga aggtgccgaa      420

gcaaaaccgt ggtatgaacc gatttatctt ggtggtgttt ttcagctgga aaagggtgat      480

cgtctgagcg cagaaattaa tcgtccggat tatctggatt ttgcagaaag cggtcaggtg      540

tattttggca ttattgcatt ataa                                             564


<210>  70
<211>  187
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Beta10*-TNF

<400>  70

Met Val Ser Gly Trp Arg Leu Phe Lys Lys Ile Ser Gly Gly Gly Ser 
1               5                   10                  15      


Gly His His His His His His His His Gly Gly Gly Ser Gly Val Arg 
            20                  25                  30          


Ser Ser Ser Arg Thr Pro Ser Asp Lys Pro Val Ala His Val Val Ala 
        35                  40                  45              


Asn Pro Gln Ala Glu Gly Gln Leu Gln Trp Leu Asn Arg Arg Ala Asn 
    50                  55                  60                  


Ala Leu Leu Ala Asn Gly Val Glu Leu Arg Asp Asn Gln Leu Val Val 
65                  70                  75                  80  


Pro Ser Glu Gly Leu Tyr Leu Ile Tyr Ser Gln Val Leu Phe Lys Gly 
                85                  90                  95      


Gln Gly Cys Pro Ser Thr His Val Leu Leu Thr His Thr Ile Ser Arg 
            100                 105                 110         


Ile Ala Val Ser Tyr Gln Thr Lys Val Asn Leu Leu Ser Ala Ile Lys 
        115                 120                 125             


Ser Pro Cys Gln Arg Glu Thr Pro Glu Gly Ala Glu Ala Lys Pro Trp 
    130                 135                 140                 


Tyr Glu Pro Ile Tyr Leu Gly Gly Val Phe Gln Leu Glu Lys Gly Asp 
145                 150                 155                 160 


Arg Leu Ser Ala Glu Ile Asn Arg Pro Asp Tyr Leu Asp Phe Ala Glu 
                165                 170                 175     


Ser Gly Gln Val Tyr Phe Gly Ile Ile Ala Leu 
            180                 185         


<210>  71
<211>  564
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TNF-Beta10*

<400>  71
atggttcgta gcagcagtcg taccccgagc gataaaccgg ttgcacatgt tgttgcaaat       60

ccgcaggccg aaggtcagct gcagtggctg aatcgtcgtg caaatgcact gctggcaaat      120

ggtgttgaac tgcgtgataa tcagctggtt gttccgagcg aaggtctgta tctgatttat      180

agccaggttc tgtttaaagg tcagggttgt ccgagcacac atgttctgct gacccatacc      240

attagccgta ttgcagttag ctatcagacc aaagttaatc tgctgagcgc aattaaaagc      300

ccgtgtcagc gtgaaacacc ggaaggtgcc gaagcaaaac cgtggtatga accgatttat      360

cttggtggtg tttttcagct ggaaaagggt gatcgtctga gcgcagaaat taatcgtccg      420

gattatctgg attttgcaga aagcggtcag gtgtattttg gcattattgc attaggtggt      480

ggtagcggtc atcatcacca ccatcaccat catggtggtg gcagtggtgt gagcggttgg      540

cgtctgttca aaaaaatcag ctaa                                             564


<210>  72
<211>  187
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TNF-Beta10*

<400>  72

Met Val Arg Ser Ser Ser Arg Thr Pro Ser Asp Lys Pro Val Ala His 
1               5                   10                  15      


Val Val Ala Asn Pro Gln Ala Glu Gly Gln Leu Gln Trp Leu Asn Arg 
            20                  25                  30          


Arg Ala Asn Ala Leu Leu Ala Asn Gly Val Glu Leu Arg Asp Asn Gln 
        35                  40                  45              


Leu Val Val Pro Ser Glu Gly Leu Tyr Leu Ile Tyr Ser Gln Val Leu 
    50                  55                  60                  


Phe Lys Gly Gln Gly Cys Pro Ser Thr His Val Leu Leu Thr His Thr 
65                  70                  75                  80  


Ile Ser Arg Ile Ala Val Ser Tyr Gln Thr Lys Val Asn Leu Leu Ser 
                85                  90                  95      


Ala Ile Lys Ser Pro Cys Gln Arg Glu Thr Pro Glu Gly Ala Glu Ala 
            100                 105                 110         


Lys Pro Trp Tyr Glu Pro Ile Tyr Leu Gly Gly Val Phe Gln Leu Glu 
        115                 120                 125             


Lys Gly Asp Arg Leu Ser Ala Glu Ile Asn Arg Pro Asp Tyr Leu Asp 
    130                 135                 140                 


Phe Ala Glu Ser Gly Gln Val Tyr Phe Gly Ile Ile Ala Leu Gly Gly 
145                 150                 155                 160 


Gly Ser Gly His His His His His His His His Gly Gly Gly Ser Gly 
                165                 170                 175     


Val Ser Gly Trp Arg Leu Phe Lys Lys Ile Ser 
            180                 185         


<210>  73
<211>  282
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Beta9-PpL

<400>  73
atgggtagta tgctgtttcg tgttaccatt aacagcggtg gtggtagcgg tcatcatcac       60

caccatcacc atcatggtgg tggcagtggt agcgaagtga ccattaaagt gaacctgatt      120

tttgcggatg gcaaaattca gaccgcagaa tttaaaggca cctttgaaga agcaacagcc      180

gaagcatatc gttatgcagc actgctggca aaagttaatg gtgaatatac cgcagatctg      240

gaagatggtg gtaatcacat gaatatcaaa ttcgcaggct aa                         282


<210>  74
<211>  93
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Beta9-PpL

<400>  74

Met Gly Ser Met Leu Phe Arg Val Thr Ile Asn Ser Gly Gly Gly Ser 
1               5                   10                  15      


Gly His His His His His His His His Gly Gly Gly Ser Gly Ser Glu 
            20                  25                  30          


Val Thr Ile Lys Val Asn Leu Ile Phe Ala Asp Gly Lys Ile Gln Thr 
        35                  40                  45              


Ala Glu Phe Lys Gly Thr Phe Glu Glu Ala Thr Ala Glu Ala Tyr Arg 
    50                  55                  60                  


Tyr Ala Ala Leu Leu Ala Lys Val Asn Gly Glu Tyr Thr Ala Asp Leu 
65                  70                  75                  80  


Glu Asp Gly Gly Asn His Met Asn Ile Lys Phe Ala Gly 
                85                  90              


<210>  75
<211>  282
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PpL-Beta9

<400>  75
atgagcgaag tgaccattaa agtgaacctg atttttgcgg atggcaaaat tcagaccgca       60

gaatttaaag gcacctttga agaagcaaca gccgaagcat atcgttatgc agcactgctg      120

gcaaaagtta atggtgaata taccgcagat ctggaagatg gtggtaatca catgaatatc      180

aaattcgcag gcggtggtgg tagcggtcat catcaccacc atcaccatca tggtggtggc      240

agtggtggta gtatgctgtt tcgtgttacc attaacagct aa                         282


<210>  76
<211>  93
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PpL-Beta9

<400>  76

Met Ser Glu Val Thr Ile Lys Val Asn Leu Ile Phe Ala Asp Gly Lys 
1               5                   10                  15      


Ile Gln Thr Ala Glu Phe Lys Gly Thr Phe Glu Glu Ala Thr Ala Glu 
            20                  25                  30          


Ala Tyr Arg Tyr Ala Ala Leu Leu Ala Lys Val Asn Gly Glu Tyr Thr 
        35                  40                  45              


Ala Asp Leu Glu Asp Gly Gly Asn His Met Asn Ile Lys Phe Ala Gly 
    50                  55                  60                  


Gly Gly Gly Ser Gly His His His His His His His His Gly Gly Gly 
65                  70                  75                  80  


Ser Gly Gly Ser Met Leu Phe Arg Val Thr Ile Asn Ser 
                85                  90              


<210>  77
<211>  282
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Beta10-PpL

<400>  77
atggtgagcg gttggcgtct gttcaaaaaa atcagcggtg gtggtagcgg tcatcatcac       60

caccatcacc atcatggtgg tggcagtggt agcgaagtga ccattaaagt gaacctgatt      120

tttgcggatg gcaaaattca gaccgcagaa tttaaaggca cctttgaaga agcaacagcc      180

gaagcatatc gttatgcagc actgctggca aaagttaatg gtgaatatac cgcagatctg      240

gaagatggtg gtaatcacat gaatatcaaa ttcgcaggct aa                         282


<210>  78
<211>  93
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Beta10-PpL

<400>  78

Met Val Ser Gly Trp Arg Leu Phe Lys Lys Ile Ser Gly Gly Gly Ser 
1               5                   10                  15      


Gly His His His His His His His His Gly Gly Gly Ser Gly Ser Glu 
            20                  25                  30          


Val Thr Ile Lys Val Asn Leu Ile Phe Ala Asp Gly Lys Ile Gln Thr 
        35                  40                  45              


Ala Glu Phe Lys Gly Thr Phe Glu Glu Ala Thr Ala Glu Ala Tyr Arg 
    50                  55                  60                  


Tyr Ala Ala Leu Leu Ala Lys Val Asn Gly Glu Tyr Thr Ala Asp Leu 
65                  70                  75                  80  


Glu Asp Gly Gly Asn His Met Asn Ile Lys Phe Ala Gly 
                85                  90              


<210>  79
<211>  282
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PpL-Beta10*

<400>  79
atgagcgaag tgaccattaa agtgaacctg atttttgcgg atggcaaaat tcagaccgca       60

gaatttaaag gcacctttga agaagcaaca gccgaagcat atcgttatgc agcactgctg      120

gcaaaagtta atggtgaata taccgcagat ctggaagatg gtggtaatca catgaatatc      180

aaattcgcag gcggtggtgg tagcggtcat catcaccacc atcaccatca tggtggtggc      240

agtggtgtga gcggttggcg tctgttcaaa aaaatcagct aa                         282


<210>  80
<211>  93
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PpL-Beta10*

<400>  80

Met Ser Glu Val Thr Ile Lys Val Asn Leu Ile Phe Ala Asp Gly Lys 
1               5                   10                  15      


Ile Gln Thr Ala Glu Phe Lys Gly Thr Phe Glu Glu Ala Thr Ala Glu 
            20                  25                  30          


Ala Tyr Arg Tyr Ala Ala Leu Leu Ala Lys Val Asn Gly Glu Tyr Thr 
        35                  40                  45              


Ala Asp Leu Glu Asp Gly Gly Asn His Met Asn Ile Lys Phe Ala Gly 
    50                  55                  60                  


Gly Gly Gly Ser Gly His His His His His His His His Gly Gly Gly 
65                  70                  75                  80  


Ser Gly Val Ser Gly Trp Arg Leu Phe Lys Lys Ile Ser 
                85                  90              


<210>  81
<211>  258
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Beta9-SpA

<400>  81
atgggtagta tgctgtttcg tgttaccatt aacagcggtg gtggtagcgg tcatcatcac       60

caccatcacc atcatggtgg tggcagtggt agctacaaca aagatcagca gagcgccttt      120

tatgaaattc tgaatatgcc gaatctgaat gaagcacagc gcaatggttt tattcagagc      180

ctgaaagatg atccgagcca gagcaccaat gttctgggtg aagcaaaaaa actgaatgaa      240

agccaggcac cgaaataa                                                    258


<210>  82
<211>  85
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Beta9-SpA

<400>  82

Met Gly Ser Met Leu Phe Arg Val Thr Ile Asn Ser Gly Gly Gly Ser 
1               5                   10                  15      


Gly His His His His His His His His Gly Gly Gly Ser Gly Ser Tyr 
            20                  25                  30          


Asn Lys Asp Gln Gln Ser Ala Phe Tyr Glu Ile Leu Asn Met Pro Asn 
        35                  40                  45              


Leu Asn Glu Ala Gln Arg Asn Gly Phe Ile Gln Ser Leu Lys Asp Asp 
    50                  55                  60                  


Pro Ser Gln Ser Thr Asn Val Leu Gly Glu Ala Lys Lys Leu Asn Glu 
65                  70                  75                  80  


Ser Gln Ala Pro Lys 
                85  


<210>  83
<211>  258
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SpA-Beta9

<400>  83
atgagctaca acaaagatca gcagagcgcc ttttatgaaa ttctgaatat gccgaatctg       60

aatgaagcac agcgcaatgg ttttattcag agcctgaaag atgatccgag ccagagcacc      120

aatgttctgg gtgaagcaaa aaaactgaat gaaagccagg caccgaaagg tggtggtagc      180

ggtcatcatc accaccatca ccatcatggt ggtggcagtg gtggtagtat gctgtttcgt      240

gttaccatta acagctaa                                                    258


<210>  84
<211>  85
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SpA-Beta9

<400>  84

Met Ser Tyr Asn Lys Asp Gln Gln Ser Ala Phe Tyr Glu Ile Leu Asn 
1               5                   10                  15      


Met Pro Asn Leu Asn Glu Ala Gln Arg Asn Gly Phe Ile Gln Ser Leu 
            20                  25                  30          


Lys Asp Asp Pro Ser Gln Ser Thr Asn Val Leu Gly Glu Ala Lys Lys 
        35                  40                  45              


Leu Asn Glu Ser Gln Ala Pro Lys Gly Gly Gly Ser Gly His His His 
    50                  55                  60                  


His His His His His Gly Gly Gly Ser Gly Gly Ser Met Leu Phe Arg 
65                  70                  75                  80  


Val Thr Ile Asn Ser 
                85  


<210>  85
<211>  258
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Beta10*-SpA

<400>  85
atggtgagcg gttggcgtct gttcaaaaaa atcagcggtg gtggtagcgg tcatcatcac       60

caccatcacc atcatggtgg tggcagtggt agctacaaca aagatcagca gagcgccttt      120

tatgaaattc tgaatatgcc gaatctgaat gaagcacagc gcaatggttt tattcagagc      180

ctgaaagatg atccgagcca gagcaccaat gttctgggtg aagcaaaaaa actgaatgaa      240

agccaggcac cgaaataa                                                    258


<210>  86
<211>  85
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Beta10*-SpA

<400>  86

Met Val Ser Gly Trp Arg Leu Phe Lys Lys Ile Ser Gly Gly Gly Ser 
1               5                   10                  15      


Gly His His His His His His His His Gly Gly Gly Ser Gly Ser Tyr 
            20                  25                  30          


Asn Lys Asp Gln Gln Ser Ala Phe Tyr Glu Ile Leu Asn Met Pro Asn 
        35                  40                  45              


Leu Asn Glu Ala Gln Arg Asn Gly Phe Ile Gln Ser Leu Lys Asp Asp 
    50                  55                  60                  


Pro Ser Gln Ser Thr Asn Val Leu Gly Glu Ala Lys Lys Leu Asn Glu 
65                  70                  75                  80  


Ser Gln Ala Pro Lys 
                85  


<210>  87
<211>  258
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SpA-Beta10*

<400>  87
atgagctaca acaaagatca gcagagcgcc ttttatgaaa ttctgaatat gccgaatctg       60

aatgaagcac agcgcaatgg ttttattcag agcctgaaag atgatccgag ccagagcacc      120

aatgttctgg gtgaagcaaa aaaactgaat gaaagccagg caccgaaagg tggtggtagc      180

ggtcatcatc accaccatca ccatcatggt ggtggcagtg gtgtgagcgg ttggcgtctg      240

ttcaaaaaaa tcagctaa                                                    258


<210>  88
<211>  85
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SpA-Beta10*

<400>  88

Met Ser Tyr Asn Lys Asp Gln Gln Ser Ala Phe Tyr Glu Ile Leu Asn 
1               5                   10                  15      


Met Pro Asn Leu Asn Glu Ala Gln Arg Asn Gly Phe Ile Gln Ser Leu 
            20                  25                  30          


Lys Asp Asp Pro Ser Gln Ser Thr Asn Val Leu Gly Glu Ala Lys Lys 
        35                  40                  45              


Leu Asn Glu Ser Gln Ala Pro Lys Gly Gly Gly Ser Gly His His His 
    50                  55                  60                  


His His His His His Gly Gly Gly Ser Gly Val Ser Gly Trp Arg Leu 
65                  70                  75                  80  


Phe Lys Lys Ile Ser 
                85  


<210>  89
<211>  267
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Beta9-SpGA1

<400>  89
atgggtagta tgctgtttcg tgttaccatt aacagcggtg gtggtagcgg tcatcatcac       60

caccatcacc atcatggtgg tggcagtggt gcagtgacca cctataaact ggttattaat      120

ggtcgtaccc tgagcggtta taccaccacc accgcagttg atgcagaaac cgcagaaaaa      180

gcatttaaac agtatgccta tgtgcatgaa gttgatggtg tttggaccta tgatgatgca      240

accaaaacct ttaccgttac cgaataa                                          267


<210>  90
<211>  88
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Beta9-SpGA1

<400>  90

Met Gly Ser Met Leu Phe Arg Val Thr Ile Asn Ser Gly Gly Gly Ser 
1               5                   10                  15      


Gly His His His His His His His His Gly Gly Gly Ser Gly Ala Val 
            20                  25                  30          


Thr Thr Tyr Lys Leu Val Ile Asn Gly Arg Thr Leu Ser Gly Tyr Thr 
        35                  40                  45              


Thr Thr Thr Ala Val Asp Ala Glu Thr Ala Glu Lys Ala Phe Lys Gln 
    50                  55                  60                  


Tyr Ala Tyr Val His Glu Val Asp Gly Val Trp Thr Tyr Asp Asp Ala 
65                  70                  75                  80  


Thr Lys Thr Phe Thr Val Thr Glu 
                85              


<210>  91
<211>  267
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SpGA1-Beta9

<400>  91
atggcagtga ccacctataa actggttatt aatggtcgta ccctgagcgg ttataccacc       60

accaccgcag ttgatgcaga aaccgcagaa aaagcattta aacagtatgc ctatgtgcat      120

gaagttgatg gtgtttggac ctatgatgat gcaaccaaaa cctttaccgt taccgaaggt      180

ggtggtagcg gtcatcatca ccaccatcac catcatggtg gtggcagtgg tggtagtatg      240

ctgtttcgtg ttaccattaa cagctaa                                          267


<210>  92
<211>  88
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SpGA1-Beta9

<400>  92

Met Ala Val Thr Thr Tyr Lys Leu Val Ile Asn Gly Arg Thr Leu Ser 
1               5                   10                  15      


Gly Tyr Thr Thr Thr Thr Ala Val Asp Ala Glu Thr Ala Glu Lys Ala 
            20                  25                  30          


Phe Lys Gln Tyr Ala Tyr Val His Glu Val Asp Gly Val Trp Thr Tyr 
        35                  40                  45              


Asp Asp Ala Thr Lys Thr Phe Thr Val Thr Glu Gly Gly Gly Ser Gly 
    50                  55                  60                  


His His His His His His His His Gly Gly Gly Ser Gly Gly Ser Met 
65                  70                  75                  80  


Leu Phe Arg Val Thr Ile Asn Ser 
                85              


<210>  93
<211>  267
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Beta10*-SpGA1

<400>  93
atggtgagcg gttggcgtct gttcaaaaaa atcagcggtg gtggtagcgg tcatcatcac       60

caccatcacc atcatggtgg tggcagtggt gcagtgacca cctataaact ggttattaat      120

ggtcgtaccc tgagcggtta taccaccacc accgcagttg atgcagaaac cgcagaaaaa      180

gcatttaaac agtatgccta tgtgcatgaa gttgatggtg tttggaccta tgatgatgca      240

accaaaacct ttaccgttac cgaataa                                          267


<210>  94
<211>  88
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Beta10*-SpGA1

<400>  94

Met Val Ser Gly Trp Arg Leu Phe Lys Lys Ile Ser Gly Gly Gly Ser 
1               5                   10                  15      


Gly His His His His His His His His Gly Gly Gly Ser Gly Ala Val 
            20                  25                  30          


Thr Thr Tyr Lys Leu Val Ile Asn Gly Arg Thr Leu Ser Gly Tyr Thr 
        35                  40                  45              


Thr Thr Thr Ala Val Asp Ala Glu Thr Ala Glu Lys Ala Phe Lys Gln 
    50                  55                  60                  


Tyr Ala Tyr Val His Glu Val Asp Gly Val Trp Thr Tyr Asp Asp Ala 
65                  70                  75                  80  


Thr Lys Thr Phe Thr Val Thr Glu 
                85              


<210>  95
<211>  267
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SpGA1-Beta10

<400>  95
atggcagtga ccacctataa actggttatt aatggtcgta ccctgagcgg ttataccacc       60

accaccgcag ttgatgcaga aaccgcagaa aaagcattta aacagtatgc ctatgtgcat      120

gaagttgatg gtgtttggac ctatgatgat gcaaccaaaa cctttaccgt taccgaaggt      180

ggtggtagcg gtcatcatca ccaccatcac catcatggtg gtggcagtgg tgtgagcggt      240

tggcgtctgt tcaaaaaaat cagctaa                                          267


<210>  96
<211>  88
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SpGA1-Beta10*

<400>  96

Met Ala Val Thr Thr Tyr Lys Leu Val Ile Asn Gly Arg Thr Leu Ser 
1               5                   10                  15      


Gly Tyr Thr Thr Thr Thr Ala Val Asp Ala Glu Thr Ala Glu Lys Ala 
            20                  25                  30          


Phe Lys Gln Tyr Ala Tyr Val His Glu Val Asp Gly Val Trp Thr Tyr 
        35                  40                  45              


Asp Asp Ala Thr Lys Thr Phe Thr Val Thr Glu Gly Gly Gly Ser Gly 
    50                  55                  60                  


His His His His His His His His Gly Gly Gly Ser Gly Val Ser Gly 
65                  70                  75                  80  


Trp Arg Leu Phe Lys Lys Ile Ser 
                85              


