                         SEQUENCE LISTING

<110>  Temple University--Of The Commonwealth System of Higher
       Zhang, Yi
       Meng, Lijun
       He, Shan
 
<120>  DLL4-expressing cells and vaccine using the same

<130>  206017-0093-00-WO.606297

<150>  US 62/327,599
<151>  2016-04-26

<160>  2     

<170>  PatentIn version 3.5

<210>  1
<211>  2058
<212>  DNA
<213>  Homo sapiens

<400>  1
atggcggcag cgtcccggag cgcctctggc tgggcgctac tgctgctggt ggcactttgg       60

cagcagcgcg cggccggctc cggcgtcttc cagctgcagc tgcaggagtt catcaacgag      120

cgcggcgtac tggccagtgg gcggccttgc gagcccggct gccggacttt cttccgcgtc      180

tgccttaagc acttccaggc ggtcgtctcg cccggaccct gcaccttcgg gaccgtctcc      240

acgccggtat tgggcaccaa ctccttcgct gtccgggacg acagtagcgg cggggggcgc      300

aaccctctcc aactgccctt caatttcacc tggccgggta ccttctcgct catcatcgaa      360

gcttggcacg cgccaggaga cgacctgcgg ccagaggcct tgccaccaga tgcactcatc      420

agcaagatcg ccatccaggg ctccctagct gtgggtcaga actggttatt ggatgagcaa      480

accagcaccc tcacaaggct gcgctactct taccgggtca tctgcagtga caactactat      540

ggagacaact gctcccgcct gtgcaagaag cgcaatgacc acttcggcca ctatgtgtgc      600

cagccagatg gcaacttgtc ctgcctgccc ggttggactg gggaatattg ccaacagcct      660

atctgtcttt cgggctgtca tgaacagaat ggctactgca gcaagccagc agagtgcctc      720

tgccgcccag gctggcaggg ccggctgtgt aacgaatgca tcccccacaa tggctgtcgc      780

cacggcacct gcagcactcc ctggcaatgt acttgtgatg agggctgggg aggcctgttt      840

tgtgaccaag atctcaacta ctgcacccac cactccccat gcaagaatgg ggcaacgtgc      900

tccaacagtg ggcagcgaag ctacacctgc acctgtcgcc caggctacac tggtgtggac      960

tgtgagctgg agctcagcga gtgtgacagc aacccctgtc gcaatggagg cagctgtaag     1020

gaccaggagg atggctacca ctgcctgtgt cctccgggct actatggcct gcattgtgaa     1080

cacagcacct tgagctgcgc cgactccccc tgcttcaatg ggggctcctg ccgggagcgc     1140

aaccaggggg ccaactatgc ttgtgaatgt ccccccaact tcaccggctc caactgcgag     1200

aagaaagtgg acaggtgcac cagcaacccc tgtgccaacg ggggacagtg cctgaaccga     1260

ggtccaagcc gcatgtgccg ctgccgtcct ggattcacgg gcacctactg tgaactccac     1320

gtcagcgact gtgcccgtaa cccttgcgcc cacggtggca cttgccatga cctggagaat     1380

gggctcatgt gcacctgccc tgccggcttc tctggccgac gctgtgaggt gcggacatcc     1440

atcgatgcct gtgcctcgag tccctgcttc aacagggcca cctgctacac cgacctctcc     1500

acagacacct ttgtgtgcaa ctgcccttat ggctttgtgg gcagccgctg cgagttcccc     1560

gtgggcttgc cgcccagctt cccctgggtg gccgtctcgc tgggtgtggg gctggcagtg     1620

ctgctggtac tgctgggcat ggtggcagtg gctgtgcggc agctgcggct tcgacggccg     1680

gacgacggca gcagggaagc catgaacaac ttgtcggact tccagaagga caacctgatt     1740

cctgccgccc agcttaaaaa cacaaaccag aagaaggagc tggaagtgga ctgtggcctg     1800

gacaagtcca actgtggcaa acagcaaaac cacacattgg actataatct ggccccaggg     1860

cccctggggc gggggaccat gccaggaaag tttccccaca gtgacaagag cttaggagag     1920

aaggcgccac tgcggttaca cagtgaaaag ccagagtgtc ggatatcagc gatatgctcc     1980

cccagggact ccatgtacca gtctgtgtgt ttgatatcag aggagaggaa tgaatgtgtc     2040

attgccacgg aggtataa                                                   2058


<210>  2
<211>  688
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Arg Asn Ala Met Ala Ala Ala Ser Arg Ser Ala Ser Gly Trp Ala 
1               5                   10                  15      


Leu Leu Leu Leu Val Ala Leu Trp Gln Gln Arg Ala Ala Gly Ser Gly 
            20                  25                  30          


Val Phe Gln Leu Gln Leu Gln Glu Phe Ile Asn Glu Arg Gly Val Leu 
        35                  40                  45              


Ala Ser Gly Arg Pro Cys Glu Pro Gly Cys Arg Thr Phe Phe Arg Val 
    50                  55                  60                  


Cys Leu Lys His Phe Gln Ala Val Val Ser Pro Gly Pro Cys Thr Phe 
65                  70                  75                  80  


Gly Thr Val Ser Thr Pro Val Leu Gly Thr Asn Ser Phe Ala Val Arg 
                85                  90                  95      


Asp Asp Ser Ser Gly Gly Gly Arg Asn Pro Leu Gln Leu Pro Phe Asn 
            100                 105                 110         


Phe Thr Trp Pro Gly Thr Phe Ser Leu Ile Ile Glu Ala Trp Ala Pro 
        115                 120                 125             


Gly Asp Asp Leu Arg Pro Glu Ala Leu Pro Pro Asp Ala Leu Ile Ser 
    130                 135                 140                 


Lys Ile Ala Ile Gln Gly Ser Leu Ala Val Gly Gln Asn Trp Leu Leu 
145                 150                 155                 160 


Asp Glu Gln Thr Ser Thr Leu Thr Arg Leu Arg Tyr Ser Tyr Arg Val 
                165                 170                 175     


Ile Cys Ser Asp Asn Tyr Tyr Gly Asp Asn Cys Ser Arg Leu Cys Lys 
            180                 185                 190         


Lys Arg Asn Asp His Phe Gly His Tyr Val Cys Gln Pro Asp Gly Asn 
        195                 200                 205             


Leu Ser Cys Leu Pro Gly Trp Thr Gly Glu Tyr Cys Gln Gln Pro Ile 
    210                 215                 220                 


Cys Leu Ser Gly Cys His Glu Gln Asn Gly Tyr Cys Ser Lys Pro Ala 
225                 230                 235                 240 


Glu Cys Leu Cys Arg Pro Gly Trp Gln Gly Arg Leu Cys Asn Glu Cys 
                245                 250                 255     


Ile Pro His Asn Gly Cys Arg His Gly Thr Cys Ser Thr Pro Trp Gln 
            260                 265                 270         


Cys Thr Cys Asp Glu Gly Trp Gly Gly Leu Phe Cys Asp Gln Asp Leu 
        275                 280                 285             


Asn Tyr Cys Thr His His Ser Pro Cys Lys Asn Gly Ala Thr Cys Ser 
    290                 295                 300                 


Asn Ser Gly Gln Arg Ser Tyr Thr Cys Thr Cys Arg Pro Gly Tyr Thr 
305                 310                 315                 320 


Gly Val Asp Cys Glu Leu Glu Leu Ser Glu Cys Asp Ser Asn Pro Cys 
                325                 330                 335     


Arg Asn Gly Gly Ser Cys Lys Asp Gln Glu Asp Gly Tyr His Cys Leu 
            340                 345                 350         


Cys Pro Pro Gly Tyr Tyr Gly Leu His Cys Glu His Ser Thr Leu Ser 
        355                 360                 365             


Cys Ala Asp Ser Pro Cys Phe Asn Gly Gly Ser Cys Arg Glu Arg Asn 
    370                 375                 380                 


Gln Gly Ala Asn Tyr Ala Cys Glu Cys Pro Pro Asn Phe Thr Gly Ser 
385                 390                 395                 400 


Asn Cys Glu Lys Lys Val Asp Arg Cys Thr Ser Asn Pro Cys Ala Asn 
                405                 410                 415     


Gly Gly Gln Cys Leu Asn Arg Gly Pro Ser Arg Met Cys Arg Cys Arg 
            420                 425                 430         


Pro Gly Phe Thr Gly Thr Tyr Cys Glu Leu His Val Ser Asp Cys Ala 
        435                 440                 445             


Arg Asn Pro Cys Ala His Gly Gly Thr Cys His Asp Leu Glu Asn Gly 
    450                 455                 460                 


Leu Met Cys Thr Cys Pro Ala Gly Phe Ser Gly Arg Arg Cys Glu Val 
465                 470                 475                 480 


Arg Thr Ser Ile Asp Ala Cys Ala Ser Ser Pro Cys Phe Asn Arg Ala 
                485                 490                 495     


Thr Cys Tyr Thr Asp Leu Ser Thr Asp Thr Phe Val Cys Asn Cys Pro 
            500                 505                 510         


Tyr Gly Phe Val Gly Ser Arg Cys Glu Phe Pro Val Gly Leu Pro Pro 
        515                 520                 525             


Ser Phe Pro Trp Val Ala Val Ser Leu Gly Val Gly Leu Ala Val Leu 
    530                 535                 540                 


Leu Val Leu Leu Gly Met Val Ala Val Ala Val Arg Gln Leu Arg Leu 
545                 550                 555                 560 


Arg Arg Pro Asp Asp Gly Ser Arg Glu Ala Met Asn Asn Leu Ser Asp 
                565                 570                 575     


Phe Gln Lys Asp Asn Leu Ile Pro Ala Ala Gln Leu Lys Asn Thr Asn 
            580                 585                 590         


Gln Lys Lys Glu Leu Glu Val Asp Cys Gly Leu Asp Lys Ser Asn Cys 
        595                 600                 605             


Gly Lys Gln Gln Asn His Thr Leu Asp Tyr Asn Leu Ala Pro Gly Pro 
    610                 615                 620                 


Leu Gly Arg Gly Thr Met Pro Gly Lys Phe Pro His Ser Asp Lys Ser 
625                 630                 635                 640 


Leu Gly Glu Lys Ala Pro Leu Arg Leu His Ser Glu Lys Pro Glu Cys 
                645                 650                 655     


Arg Ile Ser Ala Ile Cys Ser Pro Arg Asp Ser Met Tyr Gln Ser Val 
            660                 665                 670         


Cys Leu Ile Ser Glu Glu Arg Asn Glu Cys Val Ile Ala Thr Glu Val 
        675                 680                 685             


