                         SEQUENCE LISTING

<110>  Syntimmune, Inc.
       Blumberg, Laurence J.
       Blumberg, Richard S.
       Jones, Susan Dana
       Roopenian, Derry
       Holgate, Robert
       Jones, Timoth
       Hearn, Arron
 
<120>  Humanized Affinity-Matured Anti-FcRn Antibodies

<130>  162255.46276

<150>  U.S. 60/326,907
<151>  2016-04-25

<160>  48    

<170>  PatentIn version 3.5

<210>  1
<211>  15
<212>  DNA
<213>  Mus musculus


<220>
<221>  CDS
<222>  (1)..(15)

<400>  1
gac tat gga atg cac                                                     15
Asp Tyr Gly Met His                                                       
1               5                                                         


<210>  2
<211>  5
<212>  PRT
<213>  Mus musculus

<400>  2

Asp Tyr Gly Met His 
1               5   


<210>  3
<211>  51
<212>  DNA
<213>  Mus musculus


<220>
<221>  CDS
<222>  (1)..(51)

<400>  3
tac att agt agt ggc agt agt acc atc tac tat gca gac aca gtg aag         48
Tyr Ile Ser Ser Gly Ser Ser Thr Ile Tyr Tyr Ala Asp Thr Val Lys           
1               5                   10                  15                

ggc                                                                     51
Gly                                                                       
                                                                          


<210>  4
<211>  17
<212>  PRT
<213>  Mus musculus

<400>  4

Tyr Ile Ser Ser Gly Ser Ser Thr Ile Tyr Tyr Ala Asp Thr Val Lys 
1               5                   10                  15      


Gly 
    


<210>  5
<211>  33
<212>  DNA
<213>  Mus musculus


<220>
<221>  CDS
<222>  (1)..(33)

<400>  5
aag gcc agt cag agt gtg agt aat gat gta gct                             33
Lys Ala Ser Gln Ser Val Ser Asn Asp Val Ala                               
1               5                   10                                    


<210>  6
<211>  11
<212>  PRT
<213>  Mus musculus

<400>  6

Lys Ala Ser Gln Ser Val Ser Asn Asp Val Ala 
1               5                   10      


<210>  7
<211>  21
<212>  DNA
<213>  Mus musculus


<220>
<221>  CDS
<222>  (1)..(21)

<400>  7
tat gca tcc aat cgc tac act                                             21
Tyr Ala Ser Asn Arg Tyr Thr                                               
1               5                                                         


<210>  8
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  8

Tyr Ala Ser Asn Arg Tyr Thr 
1               5           


<210>  9
<211>  24
<212>  DNA
<213>  Mus musculus


<220>
<221>  CDS
<222>  (1)..(24)

<400>  9
cag cag gat tat agc tct ctc acg                                         24
Gln Gln Asp Tyr Ser Ser Leu Thr                                           
1               5                                                         


<210>  10
<211>  8
<212>  PRT
<213>  Mus musculus

<400>  10

Gln Gln Asp Tyr Ser Ser Leu Thr 
1               5               


<210>  11
<211>  357
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized


<220>
<221>  CDS
<222>  (1)..(357)

<220>
<221>  misc_feature
<222>  (91)..(105)
<223>  CDR

<220>
<221>  misc_feature
<222>  (148)..(198)
<223>  CDR

<220>
<221>  misc_feature
<222>  (295)..(324)
<223>  CDR

<400>  11
gag gtg cag ctg gtg gag tct ggg gga ggc tta gtg aag cct gga ggg         48
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly           
1               5                   10                  15                

tcc ctg aaa ctc tcc tgt gca gcc tct gga ttc act ttc agt nnn nnn         96
Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Xaa Xaa           
            20                  25                  30                    

nnn nnn nnn tgg gtt cgt cag gct cca ggg aag ggg ctg gag tgg gtt        144
Xaa Xaa Xaa Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val           
        35                  40                  45                        

gca nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn        192
Ala Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa           
    50                  55                  60                            

nnn nnn cga ttc acc atc tcc aga gac aat gcc aag aac acc ctg tat        240
Xaa Xaa Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr           
65                  70                  75                  80            

ctg caa atg aac agt ctg agg gcc gag gac acg gcc atg tat tac tgt        288
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Met Tyr Tyr Cys           
                85                  90                  95                

gca agg nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn tgg ggt caa gga        336
Ala Arg Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Trp Gly Gln Gly           
            100                 105                 110                   

acc tca gtc acc gtc tcc tca                                            357
Thr Ser Val Thr Val Ser Ser                                               
        115                                                               


<210>  12
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<221>  misc_feature
<222>  (31)..(31)
<223>  The 'Xaa' at location 31 stands for Lys, Asn, Arg, Ser, Thr, Ile,
       Met, Glu, Asp, Gly, Ala, Val, Gln, His, Pro, Leu, Tyr, Trp, Cys, 
       or Phe.

<220>
<221>  misc_feature
<222>  (32)..(32)
<223>  The 'Xaa' at location 32 stands for Lys, Asn, Arg, Ser, Thr, Ile,
       Met, Glu, Asp, Gly, Ala, Val, Gln, His, Pro, Leu, Tyr, Trp, Cys, 
       or Phe.

<220>
<221>  misc_feature
<222>  (33)..(33)
<223>  The 'Xaa' at location 33 stands for Lys, Asn, Arg, Ser, Thr, Ile,
       Met, Glu, Asp, Gly, Ala, Val, Gln, His, Pro, Leu, Tyr, Trp, Cys, 
       or Phe.

<220>
<221>  misc_feature
<222>  (34)..(34)
<223>  The 'Xaa' at location 34 stands for Lys, Asn, Arg, Ser, Thr, Ile,
       Met, Glu, Asp, Gly, Ala, Val, Gln, His, Pro, Leu, Tyr, Trp, Cys, 
       or Phe.

<220>
<221>  misc_feature
<222>  (35)..(35)
<223>  The 'Xaa' at location 35 stands for Lys, Asn, Arg, Ser, Thr, Ile,
       Met, Glu, Asp, Gly, Ala, Val, Gln, His, Pro, Leu, Tyr, Trp, Cys, 
       or Phe.

<220>
<221>  misc_feature
<222>  (50)..(50)
<223>  The 'Xaa' at location 50 stands for Lys, Asn, Arg, Ser, Thr, Ile,
       Met, Glu, Asp, Gly, Ala, Val, Gln, His, Pro, Leu, Tyr, Trp, Cys, 
       or Phe.

<220>
<221>  misc_feature
<222>  (51)..(51)
<223>  The 'Xaa' at location 51 stands for Lys, Asn, Arg, Ser, Thr, Ile,
       Met, Glu, Asp, Gly, Ala, Val, Gln, His, Pro, Leu, Tyr, Trp, Cys, 
       or Phe.

<220>
<221>  misc_feature
<222>  (52)..(52)
<223>  The 'Xaa' at location 52 stands for Lys, Asn, Arg, Ser, Thr, Ile,
       Met, Glu, Asp, Gly, Ala, Val, Gln, His, Pro, Leu, Tyr, Trp, Cys, 
       or Phe.

<220>
<221>  misc_feature
<222>  (53)..(53)
<223>  The 'Xaa' at location 53 stands for Lys, Asn, Arg, Ser, Thr, Ile,
       Met, Glu, Asp, Gly, Ala, Val, Gln, His, Pro, Leu, Tyr, Trp, Cys, 
       or Phe.

<220>
<221>  misc_feature
<222>  (54)..(54)
<223>  The 'Xaa' at location 54 stands for Lys, Asn, Arg, Ser, Thr, Ile,
       Met, Glu, Asp, Gly, Ala, Val, Gln, His, Pro, Leu, Tyr, Trp, Cys, 
       or Phe.

<220>
<221>  misc_feature
<222>  (55)..(55)
<223>  The 'Xaa' at location 55 stands for Lys, Asn, Arg, Ser, Thr, Ile,
       Met, Glu, Asp, Gly, Ala, Val, Gln, His, Pro, Leu, Tyr, Trp, Cys, 
       or Phe.

<220>
<221>  misc_feature
<222>  (56)..(56)
<223>  The 'Xaa' at location 56 stands for Lys, Asn, Arg, Ser, Thr, Ile,
       Met, Glu, Asp, Gly, Ala, Val, Gln, His, Pro, Leu, Tyr, Trp, Cys, 
       or Phe.

<220>
<221>  misc_feature
<222>  (57)..(57)
<223>  The 'Xaa' at location 57 stands for Lys, Asn, Arg, Ser, Thr, Ile,
       Met, Glu, Asp, Gly, Ala, Val, Gln, His, Pro, Leu, Tyr, Trp, Cys, 
       or Phe.

<220>
<221>  misc_feature
<222>  (58)..(58)
<223>  The 'Xaa' at location 58 stands for Lys, Asn, Arg, Ser, Thr, Ile,
       Met, Glu, Asp, Gly, Ala, Val, Gln, His, Pro, Leu, Tyr, Trp, Cys, 
       or Phe.

<220>
<221>  misc_feature
<222>  (59)..(59)
<223>  The 'Xaa' at location 59 stands for Lys, Asn, Arg, Ser, Thr, Ile,
       Met, Glu, Asp, Gly, Ala, Val, Gln, His, Pro, Leu, Tyr, Trp, Cys, 
       or Phe.

<220>
<221>  misc_feature
<222>  (60)..(60)
<223>  The 'Xaa' at location 60 stands for Lys, Asn, Arg, Ser, Thr, Ile,
       Met, Glu, Asp, Gly, Ala, Val, Gln, His, Pro, Leu, Tyr, Trp, Cys, 
       or Phe.

<220>
<221>  misc_feature
<222>  (61)..(61)
<223>  The 'Xaa' at location 61 stands for Lys, Asn, Arg, Ser, Thr, Ile,
       Met, Glu, Asp, Gly, Ala, Val, Gln, His, Pro, Leu, Tyr, Trp, Cys, 
       or Phe.

<220>
<221>  misc_feature
<222>  (62)..(62)
<223>  The 'Xaa' at location 62 stands for Lys, Asn, Arg, Ser, Thr, Ile,
       Met, Glu, Asp, Gly, Ala, Val, Gln, His, Pro, Leu, Tyr, Trp, Cys, 
       or Phe.

<220>
<221>  misc_feature
<222>  (63)..(63)
<223>  The 'Xaa' at location 63 stands for Lys, Asn, Arg, Ser, Thr, Ile,
       Met, Glu, Asp, Gly, Ala, Val, Gln, His, Pro, Leu, Tyr, Trp, Cys, 
       or Phe.

<220>
<221>  misc_feature
<222>  (64)..(64)
<223>  The 'Xaa' at location 64 stands for Lys, Asn, Arg, Ser, Thr, Ile,
       Met, Glu, Asp, Gly, Ala, Val, Gln, His, Pro, Leu, Tyr, Trp, Cys, 
       or Phe.

<220>
<221>  misc_feature
<222>  (65)..(65)
<223>  The 'Xaa' at location 65 stands for Lys, Asn, Arg, Ser, Thr, Ile,
       Met, Glu, Asp, Gly, Ala, Val, Gln, His, Pro, Leu, Tyr, Trp, Cys, 
       or Phe.

<220>
<221>  misc_feature
<222>  (66)..(66)
<223>  The 'Xaa' at location 66 stands for Lys, Asn, Arg, Ser, Thr, Ile,
       Met, Glu, Asp, Gly, Ala, Val, Gln, His, Pro, Leu, Tyr, Trp, Cys, 
       or Phe.

<220>
<221>  misc_feature
<222>  (99)..(99)
<223>  The 'Xaa' at location 99 stands for Lys, Asn, Arg, Ser, Thr, Ile,
       Met, Glu, Asp, Gly, Ala, Val, Gln, His, Pro, Leu, Tyr, Trp, Cys, 
       or Phe.

<220>
<221>  misc_feature
<222>  (100)..(100)
<223>  The 'Xaa' at location 100 stands for Lys, Asn, Arg, Ser, Thr, 
       Ile, Met, Glu, Asp, Gly, Ala, Val, Gln, His, Pro, Leu, Tyr, Trp, 
       Cys, or Phe.

<220>
<221>  misc_feature
<222>  (101)..(101)
<223>  The 'Xaa' at location 101 stands for Lys, Asn, Arg, Ser, Thr, 
       Ile, Met, Glu, Asp, Gly, Ala, Val, Gln, His, Pro, Leu, Tyr, Trp, 
       Cys, or Phe.

<220>
<221>  misc_feature
<222>  (102)..(102)
<223>  The 'Xaa' at location 102 stands for Lys, Asn, Arg, Ser, Thr, 
       Ile, Met, Glu, Asp, Gly, Ala, Val, Gln, His, Pro, Leu, Tyr, Trp, 
       Cys, or Phe.

<220>
<221>  misc_feature
<222>  (103)..(103)
<223>  The 'Xaa' at location 103 stands for Lys, Asn, Arg, Ser, Thr, 
       Ile, Met, Glu, Asp, Gly, Ala, Val, Gln, His, Pro, Leu, Tyr, Trp, 
       Cys, or Phe.

<220>
<221>  misc_feature
<222>  (104)..(104)
<223>  The 'Xaa' at location 104 stands for Lys, Asn, Arg, Ser, Thr, 
       Ile, Met, Glu, Asp, Gly, Ala, Val, Gln, His, Pro, Leu, Tyr, Trp, 
       Cys, or Phe.

<220>
<221>  misc_feature
<222>  (105)..(105)
<223>  The 'Xaa' at location 105 stands for Lys, Asn, Arg, Ser, Thr, 
       Ile, Met, Glu, Asp, Gly, Ala, Val, Gln, His, Pro, Leu, Tyr, Trp, 
       Cys, or Phe.

<220>
<221>  misc_feature
<222>  (106)..(106)
<223>  The 'Xaa' at location 106 stands for Lys, Asn, Arg, Ser, Thr, 
       Ile, Met, Glu, Asp, Gly, Ala, Val, Gln, His, Pro, Leu, Tyr, Trp, 
       Cys, or Phe.

<220>
<221>  misc_feature
<222>  (107)..(107)
<223>  The 'Xaa' at location 107 stands for Lys, Asn, Arg, Ser, Thr, 
       Ile, Met, Glu, Asp, Gly, Ala, Val, Gln, His, Pro, Leu, Tyr, Trp, 
       Cys, or Phe.

<220>
<221>  misc_feature
<222>  (108)..(108)
<223>  The 'Xaa' at location 108 stands for Lys, Asn, Arg, Ser, Thr, 
       Ile, Met, Glu, Asp, Gly, Ala, Val, Gln, His, Pro, Leu, Tyr, Trp, 
       Cys, or Phe.

<220>
<223>  Synthetic Construct

<400>  12

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Xaa Xaa 
            20                  25                  30          


Xaa Xaa Xaa Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    50                  55                  60                  


Xaa Xaa Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Trp Gly Gln Gly 
            100                 105                 110         


Thr Ser Val Thr Val Ser Ser 
        115                 


<210>  13
<211>  357
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized


<220>
<221>  CDS
<222>  (1)..(357)

<220>
<221>  misc_feature
<222>  (91)..(105)
<223>  CDR

<220>
<221>  misc_feature
<222>  (148)..(198)
<223>  CDR

<220>
<221>  misc_feature
<222>  (295)..(324)
<223>  CDR

<400>  13
gag gtg cag ctg gtg gag tct ggg gga ggc tta gtg aag cct gga ggg         48
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly           
1               5                   10                  15                

tcc ctg aaa ctc tcc tgt gca gcc tct gga ttc act ttc agt nnn nnn         96
Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Xaa Xaa           
            20                  25                  30                    

nnn nnn nnn tgg gtt cgt cag gct cca ggg aag ggg ctg gag tgg gtt        144
Xaa Xaa Xaa Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val           
        35                  40                  45                        

gca nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn        192
Ala Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa           
    50                  55                  60                            

nnn nnn cga ttc acc atc tcc aga gac aat gcc aag aac acc ctg tat        240
Xaa Xaa Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr           
65                  70                  75                  80            

ctg caa atg aac agt ctg agg gcc gag gac acg gcc gtg tat tac tgt        288
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys           
                85                  90                  95                

gca agg nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn tgg ggt caa gga        336
Ala Arg Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Trp Gly Gln Gly           
            100                 105                 110                   

acc acg gtc acc gtc tcc tca                                            357
Thr Thr Val Thr Val Ser Ser                                               
        115                                                               


<210>  14
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<221>  misc_feature
<222>  (31)..(31)
<223>  The 'Xaa' at location 31 stands for Lys, Asn, Arg, Ser, Thr, Ile,
       Met, Glu, Asp, Gly, Ala, Val, Gln, His, Pro, Leu, Tyr, Trp, Cys, 
       or Phe.

<220>
<221>  misc_feature
<222>  (32)..(32)
<223>  The 'Xaa' at location 32 stands for Lys, Asn, Arg, Ser, Thr, Ile,
       Met, Glu, Asp, Gly, Ala, Val, Gln, His, Pro, Leu, Tyr, Trp, Cys, 
       or Phe.

<220>
<221>  misc_feature
<222>  (33)..(33)
<223>  The 'Xaa' at location 33 stands for Lys, Asn, Arg, Ser, Thr, Ile,
       Met, Glu, Asp, Gly, Ala, Val, Gln, His, Pro, Leu, Tyr, Trp, Cys, 
       or Phe.

<220>
<221>  misc_feature
<222>  (34)..(34)
<223>  The 'Xaa' at location 34 stands for Lys, Asn, Arg, Ser, Thr, Ile,
       Met, Glu, Asp, Gly, Ala, Val, Gln, His, Pro, Leu, Tyr, Trp, Cys, 
       or Phe.

<220>
<221>  misc_feature
<222>  (35)..(35)
<223>  The 'Xaa' at location 35 stands for Lys, Asn, Arg, Ser, Thr, Ile,
       Met, Glu, Asp, Gly, Ala, Val, Gln, His, Pro, Leu, Tyr, Trp, Cys, 
       or Phe.

<220>
<221>  misc_feature
<222>  (50)..(50)
<223>  The 'Xaa' at location 50 stands for Lys, Asn, Arg, Ser, Thr, Ile,
       Met, Glu, Asp, Gly, Ala, Val, Gln, His, Pro, Leu, Tyr, Trp, Cys, 
       or Phe.

<220>
<221>  misc_feature
<222>  (51)..(51)
<223>  The 'Xaa' at location 51 stands for Lys, Asn, Arg, Ser, Thr, Ile,
       Met, Glu, Asp, Gly, Ala, Val, Gln, His, Pro, Leu, Tyr, Trp, Cys, 
       or Phe.

<220>
<221>  misc_feature
<222>  (52)..(52)
<223>  The 'Xaa' at location 52 stands for Lys, Asn, Arg, Ser, Thr, Ile,
       Met, Glu, Asp, Gly, Ala, Val, Gln, His, Pro, Leu, Tyr, Trp, Cys, 
       or Phe.

<220>
<221>  misc_feature
<222>  (53)..(53)
<223>  The 'Xaa' at location 53 stands for Lys, Asn, Arg, Ser, Thr, Ile,
       Met, Glu, Asp, Gly, Ala, Val, Gln, His, Pro, Leu, Tyr, Trp, Cys, 
       or Phe.

<220>
<221>  misc_feature
<222>  (54)..(54)
<223>  The 'Xaa' at location 54 stands for Lys, Asn, Arg, Ser, Thr, Ile,
       Met, Glu, Asp, Gly, Ala, Val, Gln, His, Pro, Leu, Tyr, Trp, Cys, 
       or Phe.

<220>
<221>  misc_feature
<222>  (55)..(55)
<223>  The 'Xaa' at location 55 stands for Lys, Asn, Arg, Ser, Thr, Ile,
       Met, Glu, Asp, Gly, Ala, Val, Gln, His, Pro, Leu, Tyr, Trp, Cys, 
       or Phe.

<220>
<221>  misc_feature
<222>  (56)..(56)
<223>  The 'Xaa' at location 56 stands for Lys, Asn, Arg, Ser, Thr, Ile,
       Met, Glu, Asp, Gly, Ala, Val, Gln, His, Pro, Leu, Tyr, Trp, Cys, 
       or Phe.

<220>
<221>  misc_feature
<222>  (57)..(57)
<223>  The 'Xaa' at location 57 stands for Lys, Asn, Arg, Ser, Thr, Ile,
       Met, Glu, Asp, Gly, Ala, Val, Gln, His, Pro, Leu, Tyr, Trp, Cys, 
       or Phe.

<220>
<221>  misc_feature
<222>  (58)..(58)
<223>  The 'Xaa' at location 58 stands for Lys, Asn, Arg, Ser, Thr, Ile,
       Met, Glu, Asp, Gly, Ala, Val, Gln, His, Pro, Leu, Tyr, Trp, Cys, 
       or Phe.

<220>
<221>  misc_feature
<222>  (59)..(59)
<223>  The 'Xaa' at location 59 stands for Lys, Asn, Arg, Ser, Thr, Ile,
       Met, Glu, Asp, Gly, Ala, Val, Gln, His, Pro, Leu, Tyr, Trp, Cys, 
       or Phe.

<220>
<221>  misc_feature
<222>  (60)..(60)
<223>  The 'Xaa' at location 60 stands for Lys, Asn, Arg, Ser, Thr, Ile,
       Met, Glu, Asp, Gly, Ala, Val, Gln, His, Pro, Leu, Tyr, Trp, Cys, 
       or Phe.

<220>
<221>  misc_feature
<222>  (61)..(61)
<223>  The 'Xaa' at location 61 stands for Lys, Asn, Arg, Ser, Thr, Ile,
       Met, Glu, Asp, Gly, Ala, Val, Gln, His, Pro, Leu, Tyr, Trp, Cys, 
       or Phe.

<220>
<221>  misc_feature
<222>  (62)..(62)
<223>  The 'Xaa' at location 62 stands for Lys, Asn, Arg, Ser, Thr, Ile,
       Met, Glu, Asp, Gly, Ala, Val, Gln, His, Pro, Leu, Tyr, Trp, Cys, 
       or Phe.

<220>
<221>  misc_feature
<222>  (63)..(63)
<223>  The 'Xaa' at location 63 stands for Lys, Asn, Arg, Ser, Thr, Ile,
       Met, Glu, Asp, Gly, Ala, Val, Gln, His, Pro, Leu, Tyr, Trp, Cys, 
       or Phe.

<220>
<221>  misc_feature
<222>  (64)..(64)
<223>  The 'Xaa' at location 64 stands for Lys, Asn, Arg, Ser, Thr, Ile,
       Met, Glu, Asp, Gly, Ala, Val, Gln, His, Pro, Leu, Tyr, Trp, Cys, 
       or Phe.

<220>
<221>  misc_feature
<222>  (65)..(65)
<223>  The 'Xaa' at location 65 stands for Lys, Asn, Arg, Ser, Thr, Ile,
       Met, Glu, Asp, Gly, Ala, Val, Gln, His, Pro, Leu, Tyr, Trp, Cys, 
       or Phe.

<220>
<221>  misc_feature
<222>  (66)..(66)
<223>  The 'Xaa' at location 66 stands for Lys, Asn, Arg, Ser, Thr, Ile,
       Met, Glu, Asp, Gly, Ala, Val, Gln, His, Pro, Leu, Tyr, Trp, Cys, 
       or Phe.

<220>
<221>  misc_feature
<222>  (99)..(99)
<223>  The 'Xaa' at location 99 stands for Lys, Asn, Arg, Ser, Thr, Ile,
       Met, Glu, Asp, Gly, Ala, Val, Gln, His, Pro, Leu, Tyr, Trp, Cys, 
       or Phe.

<220>
<221>  misc_feature
<222>  (100)..(100)
<223>  The 'Xaa' at location 100 stands for Lys, Asn, Arg, Ser, Thr, 
       Ile, Met, Glu, Asp, Gly, Ala, Val, Gln, His, Pro, Leu, Tyr, Trp, 
       Cys, or Phe.

<220>
<221>  misc_feature
<222>  (101)..(101)
<223>  The 'Xaa' at location 101 stands for Lys, Asn, Arg, Ser, Thr, 
       Ile, Met, Glu, Asp, Gly, Ala, Val, Gln, His, Pro, Leu, Tyr, Trp, 
       Cys, or Phe.

<220>
<221>  misc_feature
<222>  (102)..(102)
<223>  The 'Xaa' at location 102 stands for Lys, Asn, Arg, Ser, Thr, 
       Ile, Met, Glu, Asp, Gly, Ala, Val, Gln, His, Pro, Leu, Tyr, Trp, 
       Cys, or Phe.

<220>
<221>  misc_feature
<222>  (103)..(103)
<223>  The 'Xaa' at location 103 stands for Lys, Asn, Arg, Ser, Thr, 
       Ile, Met, Glu, Asp, Gly, Ala, Val, Gln, His, Pro, Leu, Tyr, Trp, 
       Cys, or Phe.

<220>
<221>  misc_feature
<222>  (104)..(104)
<223>  The 'Xaa' at location 104 stands for Lys, Asn, Arg, Ser, Thr, 
       Ile, Met, Glu, Asp, Gly, Ala, Val, Gln, His, Pro, Leu, Tyr, Trp, 
       Cys, or Phe.

<220>
<221>  misc_feature
<222>  (105)..(105)
<223>  The 'Xaa' at location 105 stands for Lys, Asn, Arg, Ser, Thr, 
       Ile, Met, Glu, Asp, Gly, Ala, Val, Gln, His, Pro, Leu, Tyr, Trp, 
       Cys, or Phe.

<220>
<221>  misc_feature
<222>  (106)..(106)
<223>  The 'Xaa' at location 106 stands for Lys, Asn, Arg, Ser, Thr, 
       Ile, Met, Glu, Asp, Gly, Ala, Val, Gln, His, Pro, Leu, Tyr, Trp, 
       Cys, or Phe.

<220>
<221>  misc_feature
<222>  (107)..(107)
<223>  The 'Xaa' at location 107 stands for Lys, Asn, Arg, Ser, Thr, 
       Ile, Met, Glu, Asp, Gly, Ala, Val, Gln, His, Pro, Leu, Tyr, Trp, 
       Cys, or Phe.

<220>
<221>  misc_feature
<222>  (108)..(108)
<223>  The 'Xaa' at location 108 stands for Lys, Asn, Arg, Ser, Thr, 
       Ile, Met, Glu, Asp, Gly, Ala, Val, Gln, His, Pro, Leu, Tyr, Trp, 
       Cys, or Phe.

<220>
<223>  Synthetic Construct

<400>  14

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Xaa Xaa 
            20                  25                  30          


Xaa Xaa Xaa Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    50                  55                  60                  


Xaa Xaa Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser 
        115                 


<210>  15
<211>  357
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized


<220>
<221>  CDS
<222>  (1)..(357)

<220>
<221>  misc_feature
<222>  (91)..(105)
<223>  CDR

<220>
<221>  misc_feature
<222>  (148)..(198)
<223>  CDR

<220>
<221>  misc_feature
<222>  (295)..(324)
<223>  CDR

<400>  15
gag gtg cag ctg gtg gag tct ggg gga ggc tta gtg aag cct gga ggg         48
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly           
1               5                   10                  15                

tcc ctg aaa ctc tcc tgt gca gcc tct gga ttc act ttc agt nnn nnn         96
Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Xaa Xaa           
            20                  25                  30                    

nnn nnn nnn tgg gtt cgt cag gct cca ggg aag ggg ctg gag tgg gtt        144
Xaa Xaa Xaa Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val           
        35                  40                  45                        

gca nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn        192
Ala Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa           
    50                  55                  60                            

nnn nnn cga ttc acc atc tcc aga gac aat gcc aag aac acc ctg tat        240
Xaa Xaa Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr           
65                  70                  75                  80            

ctg caa atg aac agt ctg agg tct gag gac acg gcc atg tat tac tgt        288
Leu Gln Met Asn Ser Leu Arg Ser Glu Asp Thr Ala Met Tyr Tyr Cys           
                85                  90                  95                

gca agg nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn tgg ggt caa gga        336
Ala Arg Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Trp Gly Gln Gly           
            100                 105                 110                   

acc acg gtc acc gtc tcc tca                                            357
Thr Thr Val Thr Val Ser Ser                                               
        115                                                               


<210>  16
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<221>  misc_feature
<222>  (31)..(31)
<223>  The 'Xaa' at location 31 stands for Lys, Asn, Arg, Ser, Thr, Ile,
       Met, Glu, Asp, Gly, Ala, Val, Gln, His, Pro, Leu, Tyr, Trp, Cys, 
       or Phe.

<220>
<221>  misc_feature
<222>  (32)..(32)
<223>  The 'Xaa' at location 32 stands for Lys, Asn, Arg, Ser, Thr, Ile,
       Met, Glu, Asp, Gly, Ala, Val, Gln, His, Pro, Leu, Tyr, Trp, Cys, 
       or Phe.

<220>
<221>  misc_feature
<222>  (33)..(33)
<223>  The 'Xaa' at location 33 stands for Lys, Asn, Arg, Ser, Thr, Ile,
       Met, Glu, Asp, Gly, Ala, Val, Gln, His, Pro, Leu, Tyr, Trp, Cys, 
       or Phe.

<220>
<221>  misc_feature
<222>  (34)..(34)
<223>  The 'Xaa' at location 34 stands for Lys, Asn, Arg, Ser, Thr, Ile,
       Met, Glu, Asp, Gly, Ala, Val, Gln, His, Pro, Leu, Tyr, Trp, Cys, 
       or Phe.

<220>
<221>  misc_feature
<222>  (35)..(35)
<223>  The 'Xaa' at location 35 stands for Lys, Asn, Arg, Ser, Thr, Ile,
       Met, Glu, Asp, Gly, Ala, Val, Gln, His, Pro, Leu, Tyr, Trp, Cys, 
       or Phe.

<220>
<221>  misc_feature
<222>  (50)..(50)
<223>  The 'Xaa' at location 50 stands for Lys, Asn, Arg, Ser, Thr, Ile,
       Met, Glu, Asp, Gly, Ala, Val, Gln, His, Pro, Leu, Tyr, Trp, Cys, 
       or Phe.

<220>
<221>  misc_feature
<222>  (51)..(51)
<223>  The 'Xaa' at location 51 stands for Lys, Asn, Arg, Ser, Thr, Ile,
       Met, Glu, Asp, Gly, Ala, Val, Gln, His, Pro, Leu, Tyr, Trp, Cys, 
       or Phe.

<220>
<221>  misc_feature
<222>  (52)..(52)
<223>  The 'Xaa' at location 52 stands for Lys, Asn, Arg, Ser, Thr, Ile,
       Met, Glu, Asp, Gly, Ala, Val, Gln, His, Pro, Leu, Tyr, Trp, Cys, 
       or Phe.

<220>
<221>  misc_feature
<222>  (53)..(53)
<223>  The 'Xaa' at location 53 stands for Lys, Asn, Arg, Ser, Thr, Ile,
       Met, Glu, Asp, Gly, Ala, Val, Gln, His, Pro, Leu, Tyr, Trp, Cys, 
       or Phe.

<220>
<221>  misc_feature
<222>  (54)..(54)
<223>  The 'Xaa' at location 54 stands for Lys, Asn, Arg, Ser, Thr, Ile,
       Met, Glu, Asp, Gly, Ala, Val, Gln, His, Pro, Leu, Tyr, Trp, Cys, 
       or Phe.

<220>
<221>  misc_feature
<222>  (55)..(55)
<223>  The 'Xaa' at location 55 stands for Lys, Asn, Arg, Ser, Thr, Ile,
       Met, Glu, Asp, Gly, Ala, Val, Gln, His, Pro, Leu, Tyr, Trp, Cys, 
       or Phe.

<220>
<221>  misc_feature
<222>  (56)..(56)
<223>  The 'Xaa' at location 56 stands for Lys, Asn, Arg, Ser, Thr, Ile,
       Met, Glu, Asp, Gly, Ala, Val, Gln, His, Pro, Leu, Tyr, Trp, Cys, 
       or Phe.

<220>
<221>  misc_feature
<222>  (57)..(57)
<223>  The 'Xaa' at location 57 stands for Lys, Asn, Arg, Ser, Thr, Ile,
       Met, Glu, Asp, Gly, Ala, Val, Gln, His, Pro, Leu, Tyr, Trp, Cys, 
       or Phe.

<220>
<221>  misc_feature
<222>  (58)..(58)
<223>  The 'Xaa' at location 58 stands for Lys, Asn, Arg, Ser, Thr, Ile,
       Met, Glu, Asp, Gly, Ala, Val, Gln, His, Pro, Leu, Tyr, Trp, Cys, 
       or Phe.

<220>
<221>  misc_feature
<222>  (59)..(59)
<223>  The 'Xaa' at location 59 stands for Lys, Asn, Arg, Ser, Thr, Ile,
       Met, Glu, Asp, Gly, Ala, Val, Gln, His, Pro, Leu, Tyr, Trp, Cys, 
       or Phe.

<220>
<221>  misc_feature
<222>  (60)..(60)
<223>  The 'Xaa' at location 60 stands for Lys, Asn, Arg, Ser, Thr, Ile,
       Met, Glu, Asp, Gly, Ala, Val, Gln, His, Pro, Leu, Tyr, Trp, Cys, 
       or Phe.

<220>
<221>  misc_feature
<222>  (61)..(61)
<223>  The 'Xaa' at location 61 stands for Lys, Asn, Arg, Ser, Thr, Ile,
       Met, Glu, Asp, Gly, Ala, Val, Gln, His, Pro, Leu, Tyr, Trp, Cys, 
       or Phe.

<220>
<221>  misc_feature
<222>  (62)..(62)
<223>  The 'Xaa' at location 62 stands for Lys, Asn, Arg, Ser, Thr, Ile,
       Met, Glu, Asp, Gly, Ala, Val, Gln, His, Pro, Leu, Tyr, Trp, Cys, 
       or Phe.

<220>
<221>  misc_feature
<222>  (63)..(63)
<223>  The 'Xaa' at location 63 stands for Lys, Asn, Arg, Ser, Thr, Ile,
       Met, Glu, Asp, Gly, Ala, Val, Gln, His, Pro, Leu, Tyr, Trp, Cys, 
       or Phe.

<220>
<221>  misc_feature
<222>  (64)..(64)
<223>  The 'Xaa' at location 64 stands for Lys, Asn, Arg, Ser, Thr, Ile,
       Met, Glu, Asp, Gly, Ala, Val, Gln, His, Pro, Leu, Tyr, Trp, Cys, 
       or Phe.

<220>
<221>  misc_feature
<222>  (65)..(65)
<223>  The 'Xaa' at location 65 stands for Lys, Asn, Arg, Ser, Thr, Ile,
       Met, Glu, Asp, Gly, Ala, Val, Gln, His, Pro, Leu, Tyr, Trp, Cys, 
       or Phe.

<220>
<221>  misc_feature
<222>  (66)..(66)
<223>  The 'Xaa' at location 66 stands for Lys, Asn, Arg, Ser, Thr, Ile,
       Met, Glu, Asp, Gly, Ala, Val, Gln, His, Pro, Leu, Tyr, Trp, Cys, 
       or Phe.

<220>
<221>  misc_feature
<222>  (99)..(99)
<223>  The 'Xaa' at location 99 stands for Lys, Asn, Arg, Ser, Thr, Ile,
       Met, Glu, Asp, Gly, Ala, Val, Gln, His, Pro, Leu, Tyr, Trp, Cys, 
       or Phe.

<220>
<221>  misc_feature
<222>  (100)..(100)
<223>  The 'Xaa' at location 100 stands for Lys, Asn, Arg, Ser, Thr, 
       Ile, Met, Glu, Asp, Gly, Ala, Val, Gln, His, Pro, Leu, Tyr, Trp, 
       Cys, or Phe.

<220>
<221>  misc_feature
<222>  (101)..(101)
<223>  The 'Xaa' at location 101 stands for Lys, Asn, Arg, Ser, Thr, 
       Ile, Met, Glu, Asp, Gly, Ala, Val, Gln, His, Pro, Leu, Tyr, Trp, 
       Cys, or Phe.

<220>
<221>  misc_feature
<222>  (102)..(102)
<223>  The 'Xaa' at location 102 stands for Lys, Asn, Arg, Ser, Thr, 
       Ile, Met, Glu, Asp, Gly, Ala, Val, Gln, His, Pro, Leu, Tyr, Trp, 
       Cys, or Phe.

<220>
<221>  misc_feature
<222>  (103)..(103)
<223>  The 'Xaa' at location 103 stands for Lys, Asn, Arg, Ser, Thr, 
       Ile, Met, Glu, Asp, Gly, Ala, Val, Gln, His, Pro, Leu, Tyr, Trp, 
       Cys, or Phe.

<220>
<221>  misc_feature
<222>  (104)..(104)
<223>  The 'Xaa' at location 104 stands for Lys, Asn, Arg, Ser, Thr, 
       Ile, Met, Glu, Asp, Gly, Ala, Val, Gln, His, Pro, Leu, Tyr, Trp, 
       Cys, or Phe.

<220>
<221>  misc_feature
<222>  (105)..(105)
<223>  The 'Xaa' at location 105 stands for Lys, Asn, Arg, Ser, Thr, 
       Ile, Met, Glu, Asp, Gly, Ala, Val, Gln, His, Pro, Leu, Tyr, Trp, 
       Cys, or Phe.

<220>
<221>  misc_feature
<222>  (106)..(106)
<223>  The 'Xaa' at location 106 stands for Lys, Asn, Arg, Ser, Thr, 
       Ile, Met, Glu, Asp, Gly, Ala, Val, Gln, His, Pro, Leu, Tyr, Trp, 
       Cys, or Phe.

<220>
<221>  misc_feature
<222>  (107)..(107)
<223>  The 'Xaa' at location 107 stands for Lys, Asn, Arg, Ser, Thr, 
       Ile, Met, Glu, Asp, Gly, Ala, Val, Gln, His, Pro, Leu, Tyr, Trp, 
       Cys, or Phe.

<220>
<221>  misc_feature
<222>  (108)..(108)
<223>  The 'Xaa' at location 108 stands for Lys, Asn, Arg, Ser, Thr, 
       Ile, Met, Glu, Asp, Gly, Ala, Val, Gln, His, Pro, Leu, Tyr, Trp, 
       Cys, or Phe.

<220>
<223>  Synthetic Construct

<400>  16

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Xaa Xaa 
            20                  25                  30          


Xaa Xaa Xaa Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    50                  55                  60                  


Xaa Xaa Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ser Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser 
        115                 


<210>  17
<211>  318
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized


<220>
<221>  CDS
<222>  (1)..(318)

<400>  17
agt att gtg atg acc cag tct ccc gac ttc ctg ctt gca tca gtg gga         48
Ser Ile Val Met Thr Gln Ser Pro Asp Phe Leu Leu Ala Ser Val Gly           
1               5                   10                  15                

gac agg gtt acc ata acc tgc aag gcc agt cag agt gtg agt aat gat         96
Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Ser Val Ser Asn Asp           
            20                  25                  30                    

gta gct tgg tac caa cag aag cca ggg cag cct cct aaa ctg ctg ata        144
Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile           
        35                  40                  45                        

tac tat gca tcc aat cgc tac act gga gtc cct gat cgc ttc act ggc        192
Tyr Tyr Ala Ser Asn Arg Tyr Thr Gly Val Pro Asp Arg Phe Thr Gly           
    50                  55                  60                            

agt gga tat ggg acg gat ttc act ctc acc atc agc agc ctg cag gct        240
Ser Gly Tyr Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Ala           
65                  70                  75                  80            

gaa gac gtg gca gtt tat ttc tgt cag cag gat tat agc tct ctc acg        288
Glu Asp Val Ala Val Tyr Phe Cys Gln Gln Asp Tyr Ser Ser Leu Thr           
                85                  90                  95                

ttc ggt cag ggg acc aag ctg gag atc aaa                                318
Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys                                   
            100                 105                                       


<210>  18
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  18

Ser Ile Val Met Thr Gln Ser Pro Asp Phe Leu Leu Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Ser Val Ser Asn Asp 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Ala Ser Asn Arg Tyr Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Tyr Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Ala 
65                  70                  75                  80  


Glu Asp Val Ala Val Tyr Phe Cys Gln Gln Asp Tyr Ser Ser Leu Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105     


<210>  19
<211>  318
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized


<220>
<221>  CDS
<222>  (1)..(318)

<400>  19
agt att gtg atg acc cag tct ccc gac tcc ctg tct gca tca gtg gga         48
Ser Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ser Ala Ser Val Gly           
1               5                   10                  15                

gac agg gtt acc ata acc tgc aag gcc agt cag agt gtg agt aat gat         96
Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Ser Val Ser Asn Asp           
            20                  25                  30                    

gta gct tgg tac caa cag aag cca ggg cag cct cct aaa ctg ctg ata        144
Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile           
        35                  40                  45                        

tac tat gca tcc aat cgc tac act gga gtc cct gat cgc ttc act ggc        192
Tyr Tyr Ala Ser Asn Arg Tyr Thr Gly Val Pro Asp Arg Phe Thr Gly           
    50                  55                  60                            

agt gga tat ggg acg gat ttc act ctc acc atc agc agc ctg cag gct        240
Ser Gly Tyr Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Ala           
65                  70                  75                  80            

gaa gac gtg gca gtt tat ttc tgt cag cag gat tat agc tct ctc acg        288
Glu Asp Val Ala Val Tyr Phe Cys Gln Gln Asp Tyr Ser Ser Leu Thr           
                85                  90                  95                

ttc ggt cag ggg acc aag ctg gag atc aaa                                318
Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys                                   
            100                 105                                       


<210>  20
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  20

Ser Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Ser Val Ser Asn Asp 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Ala Ser Asn Arg Tyr Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Tyr Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Ala 
65                  70                  75                  80  


Glu Asp Val Ala Val Tyr Phe Cys Gln Gln Asp Tyr Ser Ser Leu Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105     


<210>  21
<211>  318
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized


<220>
<221>  CDS
<222>  (1)..(318)

<400>  21
gac att gtg atg acc cag tct ccc gac tcc ctg tct gca tca gtg gga         48
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ser Ala Ser Val Gly           
1               5                   10                  15                

gac agg gtt acc ata acc tgc aag gcc agt cag agt gtg agt aat gat         96
Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Ser Val Ser Asn Asp           
            20                  25                  30                    

gta gct tgg tac caa cag aag cca ggg cag cct cct aaa ctg ctg ata        144
Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile           
        35                  40                  45                        

tac tat gca tcc aat cgc tac act gga gtc cct gat cgc ttc agt ggc        192
Tyr Tyr Ala Ser Asn Arg Tyr Thr Gly Val Pro Asp Arg Phe Ser Gly           
    50                  55                  60                            

agt gga tat ggg acg gat ttc act ctc acc atc agc agc ctg cag gct        240
Ser Gly Tyr Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Ala           
65                  70                  75                  80            

gaa gac gtg gca gtt tat ttc tgt cag cag gat tat agc tct ctc acg        288
Glu Asp Val Ala Val Tyr Phe Cys Gln Gln Asp Tyr Ser Ser Leu Thr           
                85                  90                  95                

ttc ggt cag ggg acc aag ctg gag atc aaa                                318
Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys                                   
            100                 105                                       


<210>  22
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  22

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Ser Val Ser Asn Asp 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Ala Ser Asn Arg Tyr Thr Gly Val Pro Asp Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Tyr Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Ala 
65                  70                  75                  80  


Glu Asp Val Ala Val Tyr Phe Cys Gln Gln Asp Tyr Ser Ser Leu Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105     


<210>  23
<211>  318
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized


<220>
<221>  CDS
<222>  (1)..(318)

<400>  23
gac att gtg atg acc cag tct ccc gac tcc ctg tct gca tca gtg gga         48
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ser Ala Ser Val Gly           
1               5                   10                  15                

gac agg gtt acc ata acc tgc aag gcc agt cag agt gtg agt aat gat         96
Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Ser Val Ser Asn Asp           
            20                  25                  30                    

gta gct tgg tac caa cag aag cca ggg cag cct cct aaa ctg ctg ata        144
Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile           
        35                  40                  45                        

tac tat gca tcc aat cgc tac act gga gtc cct gat cgc ttc agt ggc        192
Tyr Tyr Ala Ser Asn Arg Tyr Thr Gly Val Pro Asp Arg Phe Ser Gly           
    50                  55                  60                            

agt gga tat ggg acg gat ttc act ctc acc atc agc agc ctg cag gct        240
Ser Gly Tyr Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Ala           
65                  70                  75                  80            

gaa gac gtg gca gtt tat tac tgt cag cag gat tat agc tct ctc acg        288
Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln Asp Tyr Ser Ser Leu Thr           
                85                  90                  95                

ttc ggt cag ggg acc aag ctg gag atc aaa                                318
Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys                                   
            100                 105                                       


<210>  24
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  24

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Ser Val Ser Asn Asp 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Ala Ser Asn Arg Tyr Thr Gly Val Pro Asp Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Tyr Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Ala 
65                  70                  75                  80  


Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln Asp Tyr Ser Ser Leu Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105     


<210>  25
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Affinity Matured

<400>  25

Gly Glu Ser Thr Thr Thr Val Gly Asp Tyr 
1               5                   10  


<210>  26
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Affinity Matured

<400>  26

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Ser Ser Gly Ser Ser Thr Ile Tyr Tyr Ala Asp Thr Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Glu Ser Thr Thr Thr Val Gly Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Ser Val Thr Val Ser Ser 
        115                 


<210>  27
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Affinity Matured

<400>  27

Ala Glu Ser Thr Thr Thr Val Gly Asp Tyr 
1               5                   10  


<210>  28
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Affinity Matured

<400>  28

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Ser Ser Gly Ser Ser Thr Ile Tyr Tyr Ala Asp Thr Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala Glu Ser Thr Thr Thr Val Gly Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Ser Val Thr Val Ser Ser 
        115                 


<210>  29
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Affinity Matured

<400>  29

Phe Ser Ser Leu Ser Thr Val Gly Asp Tyr 
1               5                   10  


<210>  30
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Affinity Matured

<400>  30

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Ser Ser Gly Ser Ser Thr Ile Tyr Tyr Ala Asp Thr Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Phe Ser Ser Leu Ser Thr Val Gly Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Ser Val Thr Val Ser Ser 
        115                 


<210>  31
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Affinity Matured

<400>  31

Leu Glu Ser Thr Thr Ala Val Gly Asp Tyr 
1               5                   10  


<210>  32
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Affinity Matured

<400>  32

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Ser Ser Gly Ser Ser Thr Ile Tyr Tyr Ala Asp Thr Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Glu Ser Thr Thr Ala Val Gly Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Ser Val Thr Val Ser Ser 
        115                 


<210>  33
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Affinity Matured

<400>  33

Phe Asp Thr Pro Ala Thr Val Gly Asp Tyr 
1               5                   10  


<210>  34
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Affinity Matured

<400>  34

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Ser Ser Gly Ser Ser Thr Ile Tyr Tyr Ala Asp Thr Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Phe Asp Thr Pro Ala Thr Val Gly Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Ser Val Thr Val Ser Ser 
        115                 


<210>  35
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Affinity Matured

<400>  35

Phe Asp Thr Pro Ser Thr Val Gly Asp Tyr 
1               5                   10  


<210>  36
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Affinity Matured

<400>  36

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Ser Ser Gly Ser Ser Thr Ile Tyr Tyr Ala Asp Thr Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Phe Asp Thr Pro Ser Thr Val Gly Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Ser Val Thr Val Ser Ser 
        115                 


<210>  37
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Affinity Matured

<400>  37

Phe Asp Ser Leu Ser Thr Val Gly Asp Tyr 
1               5                   10  


<210>  38
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Affinity Matured

<400>  38

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Ser Ser Gly Ser Ser Thr Ile Tyr Tyr Ala Asp Thr Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Phe Asp Ser Leu Ser Thr Val Gly Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Ser Val Thr Val Ser Ser 
        115                 


<210>  39
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Affinity Matured

<400>  39

Leu Glu Ala Val Ser Ala Val Gly Asp Tyr 
1               5                   10  


<210>  40
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Affinity Matured

<400>  40

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Ser Ser Gly Ser Ser Thr Ile Tyr Tyr Ala Asp Thr Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Glu Ala Val Ser Ala Val Gly Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Ser Val Thr Val Ser Ser 
        115                 


<210>  41
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence


<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  n is a, c, g, or t

<400>  41
argbnsvvsb ncvncnvcrs c                                                 21


<210>  42
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence


<220>
<221>  misc_feature
<222>  (4)..(5)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  n is a, c, g, or t

<400>  42
aggnnsnnsn nsnnsrsc                                                     18


<210>  43
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Consensus


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Residue is A or L

<220>
<221>  VARIANT
<222>  (6)..(6)
<223>  Residue is T or R

<400>  43

Xaa Glu Ser Thr Thr Xaa 
1               5       


<210>  44
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Consensus


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Residue is A or L

<220>
<221>  VARIANT
<222>  (6)..(6)
<223>  Residue is T or R

<400>  44

Xaa Glu Ser Thr Thr Xaa Val Gly Asp Tyr 
1               5                   10  


<210>  45
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Consensus


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Residue is G, A, or L

<220>
<221>  VARIANT
<222>  (6)..(6)
<223>  Residue is T or R

<400>  45

Xaa Glu Ser Thr Thr Xaa 
1               5       


<210>  46
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Consensus


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Residue is G, A, or L

<220>
<221>  VARIANT
<222>  (6)..(6)
<223>  Residue is T or R

<400>  46

Xaa Glu Ser Thr Thr Xaa Val Gly Asp Tyr 
1               5                   10  


<210>  47
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Consensus


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Residue is G, A, F, or L

<220>
<221>  VARIANT
<222>  (2)..(2)
<223>  Residue is E, A, or D

<220>
<221>  VARIANT
<222>  (3)..(3)
<223>  Residue is S, T, or A

<220>
<221>  VARIANT
<222>  (4)..(4)
<223>  Residue is T, L, P, or V

<220>
<221>  VARIANT
<222>  (5)..(5)
<223>  Residue is T, S, or A

<220>
<221>  VARIANT
<222>  (6)..(6)
<223>  Residue is T or A

<400>  47

Xaa Xaa Xaa Xaa Xaa Xaa 
1               5       


<210>  48
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Consensus


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Residue is G, A, F, or L

<220>
<221>  VARIANT
<222>  (2)..(2)
<223>  Residue is E, A, or D

<220>
<221>  VARIANT
<222>  (3)..(3)
<223>  Residue is S, T, or A

<220>
<221>  VARIANT
<222>  (4)..(4)
<223>  Residue is T, L, P, or V

<220>
<221>  VARIANT
<222>  (5)..(5)
<223>  Residue is T, S, or A

<220>
<221>  VARIANT
<222>  (6)..(6)
<223>  Residue is T or A

<400>  48

Xaa Xaa Xaa Xaa Xaa Xaa Val Gly Asp Tyr 
1               5                   10  


