                         SEQUENCE LISTING

<110>  Merck Sharp & Dohme Corp.
       Palani, Anandan
       Yang, ZhiQiang
       Yan, Lin
       Lin, Songnian
       Huo, Pei
       Nargund, Ravi
 
<120>  INSULIN DIMER-INCRETIN CONJUGATES

<130>  24325

<150>  62/327,516
<151>  2016-04-26

<160>  141   

<170>  PatentIn version 3.5

<210>  1
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Glucagon-derived peptide

<400>  1

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Gln Trp Leu Leu Asp Thr 
            20                  25                  


<210>  2
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide


<220>
<221>  PEPTIDE
<222>  (1)..(31)
<223>  C-terminal amino acid optionally is linked to a protecting group 
       or amidated

<220>
<221>  PEPTIDE
<222>  (1)..(31)
<223>  with the proviso that either X10 is a Lysine residue conjugatedto
       lipid moiety and one of X20, X21, X24, X30, or X31 comprises the 
       azide group or X20 is a Lysine residue conjugated lipid moiety 
       and one of X21, X24, X30, or X31 comprises the azide group

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is amionisobutyric acid (Aib), Gly, D-Serine (s), 
       alpha-methyl Serine (?MS), or alpha-methyl D-Serine (alpha-Ms)

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is Val, Glu or Asp

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa is Asp or alpha-methyl Aspartic acid (alpha-MD)

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa is Tyr or Lys conjugated to a lipid moiety

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Xaa is Lysine, Leucine, or Serine

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa is Leu of alpha-methyl Leucine (alpha-ML)

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa is Glutamic acid, Asparagine, Serine, Alanine, or Aib

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  Xaa is Arginine or Lysine

<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  Xaa is Alanine or Arginine

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  Xaa is Glutamine or Lysine conjugated via its epsilon amino group
       to a non-peptide linker comprising a terminal azide group or to a
       fatty acid or fatty diacid

<220>
<221>  MISC_FEATURE
<222>  (21)..(21)
<223>  Xaa is Aspartic acid, ?MD, Azidonorleucine (Norleucine conjugated
       via its epsilon carbon to an azide group (Nle(?N3))), or Lysine 
       conjugated via its epsilon amino group to a non-peptide linker 
       comprising a terminal azide group

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  Xaa is Phe or alpha-MF

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Xaa is Glutamine, Nle(epsilon-N3), or Lysine conjugated via its 
       epsilon amino group to a non-peptide linker comprising a terminal
       azide group

<220>
<221>  MISC_FEATURE
<222>  (25)..(25)
<223>  Xaa is Tryptophan or alpha-methyl Tryptophan (alpha-MW);

<220>
<221>  MISC_FEATURE
<222>  (26)..(26)
<223>  Xaa is Leucine or alpha-ML

<220>
<221>  MISC_FEATURE
<222>  (27)..(27)
<223>  Xaa is Methionine, Leucine, Methionine sulfoxide, or L-methionine
       sulphone (2)

<220>
<221>  MISC_FEATURE
<222>  (28)..(28)
<223>  Xaa is Aspartic acid, Alanine, Lysine, Asparagine, gamma-Glu, 
       Glutamine, or alpha-MD

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  Xaa is Threonine or Glycine

<220>
<221>  MISC_FEATURE
<222>  (30)..(30)
<223>  Xaa is Arginine, Lysine, or Nle(epsilonN3), or Xaa is absent

<220>
<221>  MISC_FEATURE
<222>  (31)..(31)
<223>  Xaa is Glycine, gamma-Glu, Nle(epsilon-N3), or Lysine conjugated 
       via its epsilon amino group to a non-peptide linker comprising a 
       terminal azide group, or Xaa is absent

<400>  2

His Xaa Xaa Gly Thr Phe Thr Ser Xaa Xaa Ser Xaa Tyr Xaa Asp Xaa 
1               5                   10                  15      


Xaa Xaa Ala Xaa Xaa Xaa Val Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            20                  25                  30      


<210>  3
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide


<220>
<221>  PEPTIDE
<222>  (1)..(31)
<223>  C-terminal amino acid optionally is linked to a protecting group 
       or amidated

<220>
<221>  PEPTIDE
<222>  (1)..(31)
<223>  with proviso that either X10 is a Lysine residue conjugated the 
       lipid moiety and one of X20, X21, X24, X30, or X31 comprises the 
       alkyne group or X20 is a Lysine residue conjugated to the lipid 
       moiety and one of X21, X24, X30, or X31 comprises the alkyne 
       

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is aminoisobutyric acid (Aib), D-Serine (s), or alpha-methyl 
       Serine (alpha-MS)

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is Val, Glu, or Asp

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa is Asp or alpha-methyl Aspartic acid (alpha-MD)

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa is Tyr or Lys conjugated to a lipid moiety

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Xaa is Lysine, Leucine, or Serine

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa is Leu or alpha-methyl Leucine (alpha-ML)

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa is Glutamic acid, Asparagine, Serine, Alanine, or Aib

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  Xaa is Arginine or Lysine

<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  Xaa is Alanine or Arginine

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  Xaa is Glutamine or Lysine conjugated via its epsilon amino group
       to a non-peptide linker comprising a terminal alkyne group or to 
       a fatty acid or fatty diacid

<220>
<221>  MISC_FEATURE
<222>  (21)..(21)
<223>  Xaa is Aspartic acid, alpha-MD, Alkynylnorleucine (Norleucine 
       conjugated via its epsilon carbon to an alkyne group 
       (Nle(epsilon-alkyne))), or Lysine conjugated via its epsilon 
       amino group to a non-peptide linker comprising a terminal alkyne 
       

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  Xaa is Phe or alpha-methyl Phenylalanine (alpha-MF)

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Xaa is Glutamine, Nle(epsilon-alkyne), or Lysine conjugated via 
       its epsilon amino group to a non-peptide linker comprising a 
       terminal alkyne group

<220>
<221>  MISC_FEATURE
<222>  (25)..(25)
<223>  Xaa is Tryptophan or alpha-methyl Tryptophan (alpha-MW)

<220>
<221>  MISC_FEATURE
<222>  (26)..(26)
<223>  Xaa is Leucine or alpha-ML

<220>
<221>  MISC_FEATURE
<222>  (27)..(27)
<223>  Xaa is Methionine, Leucine, methionine sulfoxide, or L-methionine
       sulphone (2)

<220>
<221>  MISC_FEATURE
<222>  (28)..(28)
<223>  Xaa is Aspartic acid, Alanine, Lysine, Asparagine, gamma-Glu, 
       Glutamine, or alpha-MD

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  Xaa is Threonine or Glycine

<220>
<221>  MISC_FEATURE
<222>  (30)..(30)
<223>  Xaa is Arginine, Lysine, or Nle(epsilon-alkyne), or Xaa is absent

<220>
<221>  MISC_FEATURE
<222>  (31)..(31)
<223>  Xaa is Glycine, ?Glu, Nle(epsilon-alkyne), or Lysine conjugated 
       via its epsilon amino group to a non-peptide linker comprising a 
       terminal alkyne group, or Xaa is absent

<400>  3

His Xaa Xaa Gly Thr Phe Thr Ser Xaa Xaa Ser Xaa Tyr Xaa Asp Xaa 
1               5                   10                  15      


Xaa Xaa Ala Xaa Xaa Xaa Val Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            20                  25                  30      


<210>  4
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide


<220>
<221>  PEPTIDE
<222>  (1)..(31)
<223>  C-terminal amino acid optionally is linked to a protecting group 
       or amidated

<220>
<221>  PEPTIDE
<222>  (1)..(31)
<223>  with proviso that either X10 is a Lysine residue conjugated lipid
       moiety and one of X20, X21, X24, X30, or X31 comprises the azide 
       group or X20 is a Lysine residue conjugated lipid moiety and one 
       of X21, X24, X30, or X31 comprises the azide group

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is aminoisobutyric acid (Aib), D-Serine (s), or alpha-methyl 
       Serine (alpha-MS)

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa is Asp or alpha-methyl Aspartic acid (alpha-MD)

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa is Tyr or Lys conjugated to a lipid moiety

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Xaa is Lysine, Leucine, or Serine

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa is Glutamic acid, Asparagine, Serine, Alanine, or Aib

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  Xaa is Arginine or Lysine

<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  Xaa is Alanine or Arginine

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  Xaa is Glutamine or Lysine conjugated via its epsilon amino group
       to a non-peptide linker comprising a terminal azide group or to a
       fatty acid or fatty diacid

<220>
<221>  MISC_FEATURE
<222>  (21)..(21)
<223>  Xaa is Aspartic acid, alpha-MD, Azidonorleucine (Norleucine 
       conjugated via its epsilon carbon to an azide group 
       (Nle(epsilon-N3))), or Lysine conjugated via its epsilon amino 
       group to a non-peptide linker comprising a terminal azide group

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  Xaa is Phe or alpha-methyl Phenylalanine (alpha-MF)

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Xaa is Glutamine, Nle(epsilon-N3), or Lysine conjugated via its 
       epsilon amino group to a non-peptide linker comprising a terminal
       azide group

<220>
<221>  MISC_FEATURE
<222>  (25)..(25)
<223>  Xaa is Tryptophan or alpha-methyl Tryptophan (alpha-MW)

<220>
<221>  MISC_FEATURE
<222>  (26)..(26)
<223>  Xaa is Leucine or alpha-ML

<220>
<221>  MISC_FEATURE
<222>  (27)..(27)
<223>  Xaa is Methionine, Leucine, methionine sulfoxide, or L-methionine
       sulphone (2)

<220>
<221>  MISC_FEATURE
<222>  (28)..(28)
<223>  Xaa is Aspartic acid, Alanine, Lysine, Asparagine, ?Glu, 
       Glutamine, or alpha-MD

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  Xaa is Threonine or Glycine

<220>
<221>  MISC_FEATURE
<222>  (30)..(30)
<223>  Xaa is Arginine, Lysine, or Nle(epsilon-N3), or X30 is absent

<220>
<221>  MISC_FEATURE
<222>  (31)..(31)
<223>  Xaa is Glycine, gamma-Glu, Nle(epsilon-N3), or Lysine conjugated 
       via its epsilon amino group to a non-peptide linker comprising a 
       terminal azide group, or X31 is absent

<400>  4

His Xaa Gln Gly Thr Phe Thr Ser Xaa Xaa Ser Xaa Tyr Xaa Asp Xaa 
1               5                   10                  15      


Xaa Xaa Ala Xaa Xaa Xaa Val Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            20                  25                  30      


<210>  5
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide


<220>
<221>  PEPTIDE
<222>  (1)..(31)
<223>  C-terminal amino acid optionally is linked to a protecting group 
       or amidated

<220>
<221>  PEPTIDE
<222>  (1)..(31)
<223>  with the proviso that either X10 is a Lysine residue conjugated 
       lipid moiety and one of X20, X21, X24, X30, or X31 comprises the 
       alkyne group or X20 is a Lysine residue conjugated lipid moiety 
       and one of X21, X24, X30, or X31 comprises the alkyne group

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is aminoisobutyric acid (Aib), D-Serine (s), or alpha-methyl 
       Serine (alpha-MS)

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa is Asp or alpha-methyl Aspartic acid (alpha-MD)

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa is Tyr or Lys conjugated to a lipid moiety

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Xaa is Lysine, Leucine, or Serine

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa is Leu of alpha-methyl Leucine (alpha-ML)

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa is Glutamic acid, Asparagine, Serine, Alanine, or Aib

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  Xaa is Arginine or Lysine

<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  Xaa is Alanine or Arginine

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  Xaa is Glutamine or Lysine conjugated via its epsilon amino group
       to a non-peptide linker comprising a terminal alkyne group or to 
       a fatty acid or fatty diacid

<220>
<221>  MISC_FEATURE
<222>  (21)..(21)
<223>  Xaa is Aspartic acid, alpha-MD, Alkynylnorleucine (Norleucine 
       conjugated via its epsilon carbon to an alkyne group 
       (Nle(epsilon-alkyne))), or Lysine conjugated via its epsilon 
       amino group to a non-peptide linker comprising a terminal alkyne 
       

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  Xaa is Phe or alpha-methyl Phenylalanine (alpha-MF)

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Xaa is Glutamine, Nle(epsilon-alkyne), or Lysine conjugated via 
       its epsilon amino group to a non-peptide linker comprising a 
       terminal alkyne group

<220>
<221>  MISC_FEATURE
<222>  (25)..(25)
<223>  Xaa is Tryptophan or alpha-methyl Tryptophan (alpha-MW)

<220>
<221>  MISC_FEATURE
<222>  (26)..(26)
<223>  Xaa is Leucine or alpha-ML

<220>
<221>  MISC_FEATURE
<222>  (27)..(27)
<223>  Xaa is Methionine, Leucine, methionine sulfoxide, or L-methionine
       sulphone (2)

<220>
<221>  MISC_FEATURE
<222>  (28)..(28)
<223>  Xaa is Aspartic acid, Alanine, Lysine, Asparagine, gamma-Glu, 
       Glutamine, or alpha-MD

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  Xaa is Threonine or Glycine

<220>
<221>  MISC_FEATURE
<222>  (30)..(30)
<223>  Xaa is Arginine, Lysine, or Nle(epsilon-alkyne), or Xaa is absent
       and

<220>
<221>  MISC_FEATURE
<222>  (31)..(31)
<223>  Xaa is Glycine, gamma-Glu, Nle(epsilon-alkyne), or Lysine 
       conjugated via its epsilon amino group to a non-peptide linker 
       comprising a terminal alkyne group, or Xaa is absent

<400>  5

His Xaa Gln Gly Thr Phe Thr Ser Xaa Xaa Ser Xaa Tyr Xaa Asp Xaa 
1               5                   10                  15      


Xaa Xaa Ala Xaa Xaa Xaa Val Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            20                  25                  30      


<210>  6
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is Tyrosine, Phenylalanine, Tryptophan, or other amino acid 
       with an aromatic group

<220>
<221>  PEPTIDE
<222>  (1)..(31)
<223>  C-terminal amino acid optionally is linked to a protecting group 
       or amidated

<220>
<221>  PEPTIDE
<222>  (1)..(31)
<223>  with the proviso that either X10 is a Lysine residue conjugated 
       lipid moiety and one of X20, X21, X24, X30, or X31 comprises the 
       azide group or X20 is a Lysine residue conjugated lipid moiety 
       and one of X21, X24, X30, or X31 comprises the azide group

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is amionisobutyric acid (Aib), Gly, D-Serine (s), or 
       alpha-methyl Serine (alpha-MS)

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is Val, Glu, or Asp

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa is Asp or alpha-methyl Aspartic acid (alpha-MD)

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  X10 is Tyr or Lys conjugated to a lipid moiety

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Xaa is Isoleucine, Lysine, Leucine, or Serine

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa is Leu of alpha-methyl Leucine (alpha-ML)

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa is Glutamic acid, Asparagine, Serine, Alanine, or Aib

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  Xaa is Arginine or Lysine

<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  Xaa is Alanine or Arginine

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  Xaa is Glutamine or Lysine conjugated via its epsilon amino group
       to a non-peptide linker comprising a terminal azide group or to a
       fatty acid or fatty diacid

<220>
<221>  MISC_FEATURE
<222>  (21)..(21)
<223>  Xaa is Aspartic acid, alpha-MD, Azidonorleucine (Norleucine 
       conjugated via its epsilon carbon to an azide group 
       (Nle(epsilon-N3))), or Lysine conjugated via its epsilon amino 
       group to a non-peptide linker comprising a terminal azide group

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  Xaa is Phe or alpha-methyl Phenylalanine (alpha-MF),

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Xaa is Glutamine, Nle(epsilon-N3), or Lysine conjugated via its 
       epsilon amino group to a non-peptide linker comprising a terminal
       azide group

<220>
<221>  MISC_FEATURE
<222>  (25)..(25)
<223>  Xaa is Tryptophan or alpha-methyl Tryptophan (alpha-MW)

<220>
<221>  MISC_FEATURE
<222>  (26)..(26)
<223>  Xaa is Leucine or alpha-ML

<220>
<221>  MISC_FEATURE
<222>  (27)..(27)
<223>  Xaa is Met, Leucine, methionine sulfoxide, or L-methionine 
       sulphone (2)

<220>
<221>  MISC_FEATURE
<222>  (28)..(28)
<223>  Xaa is Aspartic acid, Alanine, Lysine, Asparagine, gamma-Glu, 
       Glutamine, or alpha-MD

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  Xaa is Threonine or Glycine

<220>
<221>  MISC_FEATURE
<222>  (30)..(30)
<223>  Xaa is Arginine, Lysine, or Nle(epsilon-N3), or Xaa is absent and

<220>
<221>  MISC_FEATURE
<222>  (31)..(31)
<223>  Xaa is Glycine, gamma-Glu, Nle(epsilon-N3), or Lysine conjugated 
       via its epsilon amino group to a non-peptide linker comprising a 
       terminal azide group, or Xaa is absent

<400>  6

Xaa Xaa Xaa Gly Thr Phe Thr Ser Xaa Xaa Ser Xaa Tyr Xaa Asp Xaa 
1               5                   10                  15      


Xaa Xaa Ala Xaa Xaa Xaa Val Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            20                  25                  30      


<210>  7
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is Tyrosine, Phenylalanine, Tryptophan, or other amino acid 
       with an aromatic group

<220>
<221>  PEPTIDE
<222>  (1)..(31)
<223>  C-terminal amino acid optionally is linked to a protecting group 
       or amidated

<220>
<221>  PEPTIDE
<222>  (1)..(31)
<223>  with the proviso that either X10 is a Lysine residue conjugated 
       to  lipid moiety and one of X20, X21, X24, X30, or X31 comprises 
       the alkyne group or X20 is a Lysine residue conjugated to lipid 
       moiety and one of X21, X24, X30, or X31 comprises the alkyne 
       

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is aminoisobutyric acid (Aib), D-Serine (s), or alpha-methyl 
       Serine (alpha-MS)

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is Val, Glu, or Asp

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa is Asp or alpha-methyl Aspartic acid (alpha-MD)

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa is Tyr or Lys conjugated to a lipid moiety

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Xaa is Isoleucine, Lysine, Leucine, or Serine

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa is Leu of alpha-methyl Leucine (alpha-ML)

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa is Glutamic acid, Asparagine, Serine, Alanine, or Aib

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  Xaa is Arginine or Lysine

<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  Xaa is Alanine or Arginine

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  Xaa is Glutamine or Lysine conjugated via its epsilon amino group
       to a non-peptide linker comprising a terminal alkyne group or to 
       a fatty acid or fatty diacid

<220>
<221>  MISC_FEATURE
<222>  (21)..(21)
<223>  Xaa is Aspartic acid, alpha-MD, Alkynylnorleucine (Norleucine 
       conjugated via its epsilon carbon to an alkyne group 
       (Nle(epsilon-alkyne))), or Lysine conjugated via its epsilon 
       amino group to a non-peptide linker comprising a terminal alkyne 
       

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  Xaa is Phe or alpha-methyl Phenylalanine (alpha-MF),

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Xaa is Glutamine, Nle(epsilon-alkyne), or Lysine conjugated via 
       its epsilon amino group to a non-peptide linker comprising a 
       terminal alkyne group

<220>
<221>  MISC_FEATURE
<222>  (26)..(26)
<223>  Xaa is Leucine or alpha-ML

<220>
<221>  MISC_FEATURE
<222>  (27)..(27)
<223>  Xaa is Methionine, Leucine, methionine sulfoxide, or L-methionine
       sulphone (2)

<220>
<221>  MISC_FEATURE
<222>  (28)..(28)
<223>  Xaa is Aspartic acid, Alanine, Lysine, Asparagine, gamma-Glu, 
       Glutamine, or alpha-MD

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  Xaa is Threonine or Glycine

<220>
<221>  MISC_FEATURE
<222>  (30)..(30)
<223>  Xaa is Arginine, Lysine, or Nle(epsilon-alkyne), or Xaa is absent
       and

<220>
<221>  MISC_FEATURE
<222>  (31)..(31)
<223>  Xaa is Glycine, gamma-Glu, Nle(epsilon-alkyne), or Lysine 
       conjugated via its epsilon amino group to a non-peptide linker 
       comprising a terminal alkyne group, or Xaa is absent and

<400>  7

Xaa Xaa Xaa Gly Thr Phe Thr Ser Xaa Xaa Ser Xaa Tyr Xaa Asp Xaa 
1               5                   10                  15      


Xaa Xaa Ala Xaa Xaa Xaa Val Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            20                  25                  30      


<210>  8
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is Tyrosine, Phenylalanine, Tryptophan, or other amino acid 
       with an aromatic group

<220>
<221>  PEPTIDE
<222>  (1)..(31)
<223>  C-terminal amino acid optionally is linked to a protecting group 
       or amidated

<220>
<221>  PEPTIDE
<222>  (1)..(31)
<223>  with the proviso that either X10 is a Lysine residue conjugated 
       to  lipid moiety and one of X20, X21, X24, X30, or X31 comprises 
       the azide group or X20 is a Lysine residue conjugated to  lipid 
       moiety and one of X21, X24, X30, or X31 comprises the azide group

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is amionisobutyric acid (Aib), Gly, D-Serine (s), or 
       alpha-methyl Serine (alpha-MS)

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa is Tyr or Lys conjugated to a lipid moiety

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Xaa is Isoleucine, Lysine, Leucine, or Serine

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa is Leu of alpha-methyl Leucine (alpha-ML)

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa is Glutamic acid, Asparagine, Serine, Alanine, or Aib

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  Xaa is Glutamic acid, Asparagine, Serine, Alanine, or Aib

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  Xaa is Arginine or Lysine

<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  Xaa is Alanine or Arginine

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  Xaa is Glutamine or Lysine conjugated via its epsilon amino group
       to a non-peptide linker comprising a terminal azide group or to a
       fatty acid or fatty diacid

<220>
<221>  MISC_FEATURE
<222>  (21)..(21)
<223>  Xaa is Aspartic acid, alpha-MD, Azidonorleucine (Norleucine 
       conjugated to an azide group (Nle(epsilonN3))), or Lysine 
       conjugated via to a non-peptide linker comprising a terminal 
       azide group

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  Xaa is Phe or alpha-methyl Phenylalanine (alpha-MF)

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Xaa is Glutamine, Nle(epsilonN3), or Lysine conjugated via its 
       epsilon amino group to a non-peptide linker comprising a terminal
       azide group

<220>
<221>  MISC_FEATURE
<222>  (25)..(25)
<223>  Xaa is Tryptophan or alpha-methyl Tryptophan (alpha-MW)

<220>
<221>  MISC_FEATURE
<222>  (26)..(26)
<223>  Xaa is Leucine or alpha-ML

<220>
<221>  MISC_FEATURE
<222>  (27)..(27)
<223>  Xaa is methionine, Leucine, methionine sulfoxide, or L-methionine
       sulphone (2)

<220>
<221>  MISC_FEATURE
<222>  (28)..(28)
<223>  Xaa is Aspartic acid, Alanine, Lysine, Asparagine, gamma-Glu, 
       Glutamine, or alpha-MD

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  Xaa is Threonine or Glycine

<220>
<221>  MISC_FEATURE
<222>  (30)..(30)
<223>  Xaa is Arginine, Lysine, or Nle(epsilonN3), or Xaa is absent and

<220>
<221>  MISC_FEATURE
<222>  (31)..(31)
<223>  XAA is Glycine, gamma-Glu, Nle(epsilonN3), or Lysine conjugated 
       via its epsilon amino group to a non-peptide linker comprising a 
       terminal azide group, or XAA is absent and

<400>  8

Xaa Xaa Gln Gly Thr Phe Thr Ser Xaa Xaa Ser Xaa Tyr Xaa Asp Xaa 
1               5                   10                  15      


Xaa Xaa Ala Xaa Xaa Xaa Val Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            20                  25                  30      


<210>  9
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is Tyrosine, Phenylalanine, Tryptophan, or other amino acid 
       with an aromatic group

<220>
<221>  PEPTIDE
<222>  (1)..(31)
<223>  C-terminal amino acid optionally is linked to a protecting group 
       or amidated

<220>
<221>  PEPTIDE
<222>  (1)..(31)
<223>  with the proviso that either X10 is a Lysine residue conjugated 
       to  lipid moiety and one of X20, X21, X24, X30, or X31 comprises 
       the alkyne group or X20 is a Lysine residue conjugated to  lipid 
       moiety and one of X21, X24, X30, or X31 comprises the alkyne 
       

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  X2 is aminoisobutyric acid (Aib), D-Serine (s), or alpha-methyl 
       Serine (alpha-MS)

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa is Asp or alpha-methyl Aspartic acid (alpha-MD)

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  X10 is Tyr or Lys conjugated to a lipid moiety

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Xaa is Isoleucine, Lysine, Leucine, or Serine

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa is Leu of alpha-methyl Leucine (alpha-ML)

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa is Glutamic acid, Asparagine, Serine, Alanine, or Aib

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  Xaa is Arginine or Lysine

<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  Xaa is Alanine or Arginine

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  Xaa is Glutamine or Lysine conjugated via its epsilon amino group
       to a non-peptide linker comprising a terminal alkyne group or to 
       a fatty acid or fatty diacid

<220>
<221>  MISC_FEATURE
<222>  (21)..(21)
<223>  Xaa is Aspartic acid, alpha-MD, Alkynylnorleucine (Norleucine 
       conjugated via its epsilon carbon to an alkyne group 
       (Nle(epsilon-alkyne))), or Lysine conjugated via its epsilon 
       amino group to a non-peptide linker comprising a terminal alkyne 
       

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  Xaa is Phe or alpha-methyl Phenylalanine (alpha-MF)

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Xaa is Glutamine, Nle(epsilon-alkyne), or Lysine conjugated via 
       its epsilon amino group to a non-peptide linker comprising a 
       terminal alkyne group

<220>
<221>  MISC_FEATURE
<222>  (25)..(25)
<223>  Xaa is Tryptophan or alpha-methyl Tryptophan (alpha-MW)

<220>
<221>  MISC_FEATURE
<222>  (26)..(26)
<223>  Xaa is Leucine or alpha-ML

<220>
<221>  MISC_FEATURE
<222>  (27)..(27)
<223>  Xaa is methionine, Leucine, methionine sulfoxide, or L-methionine
       sulphone (2)

<220>
<221>  MISC_FEATURE
<222>  (28)..(28)
<223>  Xaa is Aspartic acid, Alanine, Lysine, Asparagine, gamma-Glu, 
       Glutamine, or alpha-MD

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  Xaa is Threonine or Glycine

<220>
<221>  MISC_FEATURE
<222>  (30)..(30)
<223>  Xaa is Arginine, Lysine, or Nle(epsilon-alkyne), or Xaa is absent
       and

<220>
<221>  MISC_FEATURE
<222>  (31)..(31)
<223>  Xaa is Glycine, gamma-Glu, Nle(epsilon-alkyne), or Lysine 
       conjugated via its epsilon amino group to a non-peptide linker 
       comprising a terminal alkyne group, or Xaa is absent

<400>  9

Xaa Xaa Gln Gly Thr Phe Thr Ser Xaa Xaa Ser Xaa Tyr Xaa Asp Xaa 
1               5                   10                  15      


Xaa Xaa Ala Xaa Xaa Phe Val Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            20                  25                  30      


<210>  10
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide


<220>
<221>  PEPTIDE
<222>  (1)..(31)
<223>  C-terminal amino acid optionally is linked to a protecting group 
       or amidated

<220>
<221>  PEPTIDE
<222>  (1)..(31)
<223>  with the proviso that either X10 is a Lysine residue conjugated 
       to a gamma-Glu-gamma-Glu-C16 and one of X20, X21, X24, X30, or 
       X31 comprises azide or N3 group or X20 is a Lysine residue 
       conjugated to  PEG2PEG2-gamma-Glu-C18-OH or

<220>
<221>  PEPTIDE
<222>  (1)..(31)
<223>  the PEG2PEG2gamma-E-C20-OH and one of  X21, X24, X30, or X31 
       comprises the azide or N3 group

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is aminoisobutyric acid (Aib), D-Serine (s), or alpha-methyl 
       Serine (alpha-MS)

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa is Serine or alpha-methyl Aspartic acid (alpha-MD)

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa is Tyr or Lys conjugated to gamma-Glu-gamma-Glu-C16

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Xaa is Lysine, Leucine, or Serine

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa is Leu of alpha-methyl Leucine (alpha-ML)

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa is Glutamic acid, Asparagine, Serine, Alanine, or Aib

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  Xaa is Arginine or Lysine

<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  Xaa is Alanine or Arginine

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  Xaa is Glutamine or Lysine conjugated via its epsilon amine group
       to PEG2-C5N3, PEG2PEG2-C5N3, PEG2PEG2-gamma-Glu-C16N3, 
       PEG2PEG2-gamma-Glu-C18-OH, or PEG2PEG2gamma-E-C20-OH

<220>
<221>  MISC_FEATURE
<222>  (21)..(21)
<223>  Xaa is Aspartic acid, alpha-methyl Phenylalanine (alpha-MF), 
       alpha-MD, Azidonorleucine (Norleucine conjugated to an azide 
       group (Nle(epsilon-N3))), or Lys conjugated via its epsilon amine
       group to PEG2-C5N3 , PEG2PEG2-C5N3, or PEG2PEG2-gamma-Glu-C16N3

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Xaa is Glutamine, Nle(epsilon-N3), or Lysine conjugated to 
       PEG2PEG2-gamma-Glu-C16N3

<220>
<221>  MISC_FEATURE
<222>  (25)..(25)
<223>  Xaa is Tryptophan or alpha-methyl Tryptophan (alpha-MW)

<220>
<221>  MISC_FEATURE
<222>  (26)..(26)
<223>  Xaa is Leucine or alpha-ML

<220>
<221>  MISC_FEATURE
<222>  (27)..(27)
<223>  Xaa is Leucine or L-methionine sulphone (2)

<220>
<221>  MISC_FEATURE
<222>  (28)..(28)
<223>  Xaa is Aspartic acid, Alanine, Lysine, Asparagine, gamma-Glu, 
       Glutamine, or alpha-MD

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  Xaa is Threonine or Glycine

<220>
<221>  MISC_FEATURE
<222>  (30)..(30)
<223>  Xaa is Arginine, Lysine, or Nle(epsilon-N3), or Xaa is absent and

<220>
<221>  MISC_FEATURE
<222>  (31)..(31)
<223>  Xaa is Glycine, gamma-Glu, Nle(epsilon-N3), or Lysine conjugated 
       via its epsilon amine group to PEG2PEG2-gamma-Glu-C16N3 , 
       PEG2-C5N3 or PEG2PEG2-C5N3, or Xaa is absent

<400>  10

His Xaa Gln Gly Thr Phe Thr Ser Xaa Xaa Ser Xaa Tyr Xaa Asp Xaa 
1               5                   10                  15      


Xaa Xaa Ala Xaa Xaa Phe Val Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            20                  25                  30      


<210>  11
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide


<220>
<221>  PEPTIDE
<222>  (1)..(31)
<223>  C-terminal amino acid optionally is linked to a protecting group 
       or amidated

<220>
<221>  PEPTIDE
<222>  (1)..(31)
<223>  with the proviso that either X10 is a Lysine residue conjugated 
       to a gamma-Glu-gamma-Glu-C16 and one of X20, X21, X24, X30, or 
       X31 comprises the -alkyne or X20 is a Lysine residue conjugated 
       to the PEG2PEG2-gamma-Glu-C18-OH or the PEG2PEG2gamma-E-C20-OH

<220>
<221>  PEPTIDE
<222>  (1)..(31)
<223>  and one of  X21, X24, X30, or X31 comprises the -alkyne

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is aminoisobutyric acid (Aib), D-Serine (s), or alpha-methyl 
       Serine (alpha-MS)

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa is Serine or alpha-methyl Aspartic acid (alpha-MD)

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa is Tyr or Lys conjugated to gamma-Glu-gamma-Glu-C16

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Xaa is Lysine, Leucine, or Serine

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa is Leu of alpha-methyl Leucine (alpha-ML)

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa is Glutamic acid, Asparagine, Serine, Alanine, or Aib

<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  Xaa is Alanine or Arginine

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  X20 is Glutamine or Lysine conjugated via its epsilon amine group
       to PEG2-C5N3, PEG2PEG2-C5-alkyne, PEG2PEG2-gamma-Glu-C16-alkyne, 
       PEG2PEG2-gamma-Glu-C18-OH, or PEG2PEG2gamma-E-C20-OH

<220>
<221>  MISC_FEATURE
<222>  (21)..(21)
<223>  Xaa is Aspartic acid, alpha-methyl Phenylalanine (alpha-MF), 
       alpha-MD, Alkynylnorleucine (Norleucine conjugated via its 
       epsilon carbon to an alkyne group (Nle(epsilon-alkyne))), or Lys 
       conjugated v to PEG2-C5-alkyne, PEG2PEG2-C5-alkyne

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Xaa is Glutamine, Nle(epsilon-alkyne), or Lysine conjugated to 
       PEG2PEG2-gamma-Glu-C16-alkyne

<220>
<221>  MISC_FEATURE
<222>  (25)..(25)
<223>  Xaa is Tryptophan or alpha-methyl Tryptophan (alpha-MW)

<220>
<221>  MISC_FEATURE
<222>  (26)..(26)
<223>  Xaa is Leucine or alpha-ML

<220>
<221>  MISC_FEATURE
<222>  (27)..(27)
<223>  Xaa is Leucine or L-methionine sulphone (2)

<220>
<221>  MISC_FEATURE
<222>  (28)..(28)
<223>  Xaa is Aspartic acid, Alanine, Lysine, Asparagine, gamma-Glu, 
       Glutamine, or alpha-MD

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  Xaa is Threonine or Glycine

<220>
<221>  MISC_FEATURE
<222>  (30)..(30)
<223>  Xaa is Arginine, Lysine, or Nle(epsilon-alkyne), or Xaa is absent
       and

<220>
<221>  MISC_FEATURE
<222>  (31)..(31)
<223>  Xaa is Glycine, gamma-Glu, Nle(epsilon-alkyne), or Lysine 
       conjugated via its epsilon amine group to 
       PEG2PEG2-gamma-Glu-C16-alkyne, PEG2-C5-alkyne, 
       PEG2PEG2-C5-alkyne, or Xaa is absent

<400>  11

His Xaa Gln Gly Thr Phe Thr Ser Xaa Xaa Ser Xaa Tyr Xaa Asp Xaa 
1               5                   10                  15      


Xaa Xaa Ala Xaa Xaa Phe Val Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            20                  25                  30      


<210>  12
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide


<220>
<221>  PEPTIDE
<222>  (1)..(31)
<223>  C-terminal amino acid optionally is linked to a protecting group 
       or amidated

<220>
<221>  PEPTIDE
<222>  (1)..(31)
<223>  with the proviso that either X10 is a Lysine residue conjugated 
       to a gamma-Glu-gamma-Glu-C16 and one of X20, X21, X24, X30, or 
       X31 comprises the azide or N3 group or X20 is a Lysine residue 
       conjugated to the PEG2PEG2-gamma-Glu-C18-OH or

<220>
<221>  PEPTIDE
<222>  (1)..(31)
<223>  the PEG2PEG2gamma-E-C20-OH and one of  X21, X24, X30, or X31 
       comprises the azide or N3 group

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is aminoisobutyric acid (Aib), D-Serine (s), or alpha-methyl 
       Serine (alpha-MS)

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is Glu or Asp

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa is Serine or alpha-methyl Aspartic acid (alpha-MD)

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa is Tyr or Lys conjugated to gamma-Glu-gamma-Glu-C16

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Xaa is Lysine, Leucine, or Serine

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa is Leu of alpha-methyl Leucine (alpha-ML)

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa is Glutamic acid, Asparagine, Serine, Alanine, or Aib

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  Xaa is Arginine or Lysine

<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  Xaa is Alanine or Arginine

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  Xaa is Glutamine or Lysine conjugated via its epsilon amine group
       to PEG2-C5N3, PEG2PEG2-C5N3, PEG2PEG2-gamma-Glu-C16N3, 
       PEG2PEG2-gamma-Glu-C18-OH, or PEG2PEG2gamma-E-C20-OH

<220>
<221>  MISC_FEATURE
<222>  (21)..(21)
<223>  X21 is Aspartic acid, alpha-methyl Phenylalanine (alpha-MF), 
       alpha-MD, Azidonorleucine (Norleucine conjugated via its epsilon 
       carbon to an azide group (Nle(epsilon-N3))), or Lys conjugated v 
       to PEG2-C5N3 , PEG2PEG2-C5N3, or PEG2PEG2-gamma-Glu-C16N3

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Xaa is Glutamine, Nle(epsilon-N3), or Lysine conjugated to 
       PEG2PEG2-gamma-Glu-C16N3

<220>
<221>  MISC_FEATURE
<222>  (25)..(25)
<223>  Xaa is Tryptophan or alpha-methyl Tryptophan (alpha-MW)

<220>
<221>  MISC_FEATURE
<222>  (26)..(26)
<223>  Xaa is Leucine or alpha-ML

<220>
<221>  MISC_FEATURE
<222>  (27)..(27)
<223>  Xaa is Leucine or L-methionine sulphone (2)

<220>
<221>  MISC_FEATURE
<222>  (28)..(28)
<223>  Xaa is Aspartic acid, Alanine, Lysine, Asparagine, gamma-Glu, 
       Glutamine, or alpha-MD

<220>
<221>  MISC_FEATURE
<222>  (30)..(30)
<223>  Xaa is Arginine, Lysine, or Nle(epsilon-N3), or X30 is absent

<220>
<221>  MISC_FEATURE
<222>  (31)..(31)
<223>  Xaa is Glycine, gamma-Glu, Nle(epsilon-N3), or Lysine conjugated 
       via its epsilon amine group to PEG2PEG2-gamma-Glu-C16N3 , 
       PEG2-C5N3 or PEG2PEG2-C5N3, or Xaa is absent

<400>  12

His Xaa Xaa Gly Thr Phe Thr Ser Xaa Xaa Ser Xaa Tyr Xaa Asp Xaa 
1               5                   10                  15      


Xaa Xaa Ala Xaa Xaa Phe Val Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            20                  25                  30      


<210>  13
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Pepetide


<220>
<221>  PEPTIDE
<222>  (1)..(31)
<223>  C-terminal amino acid optionally is linked to a protecting group 
       or amidated

<220>
<221>  PEPTIDE
<222>  (1)..(31)
<223>  with the proviso that either X10 is a Lysine residue conjugated 
       to a gamma-Glu-gamma-Glu-C16 and one of X20, X21, X24, X30, or 
       X31 comprises the -alkyne or X20 is a Lysine residue conjugated 
       to the PEG2PEG2-gamma-Glu-C18-OH or

<220>
<221>  PEPTIDE
<222>  (1)..(31)
<223>  the PEG2PEG2gamma-E-C20-OH and one of  X21, X24, X30, or X31 
       comprises the -alkyne

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is aminoisobutyric acid (Aib), D-Serine (s), or alpha-methyl 
       Serine (alpha-MS)

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is Glu or Asp

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa is Serine or alpha-methyl Aspartic acid (alpha-MD)

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa is Tyr or Lys conjugated to gamma-Glu-gamma-Glu-C16

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Xaa is Lysine, Leucine, or Serine

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa is Leu of alpha-methyl Leucine (alpha-ML)

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa is Glutamic acid, Asparagine, Serine, Alanine, or Aib

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  Xaa is Arginine or Lysine

<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  Xaa is Alanine or Arginine

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  Xaa is Glutamine or Lysine conjugated via its epsilon amine group
       to PEG2-C5N3, PEG2PEG2-C5-alkyne, PEG2PEG2-gamma-Glu-C16-alkyne, 
       PEG2PEG2-gamma-Glu-C18-OH, or PEG2PEG2gamma-E-C20-OH

<220>
<221>  MISC_FEATURE
<222>  (21)..(21)
<223>  Xaa is Aspartic acid, alpha-methyl Phenylalanine (alpha-MF), 
       alpha-MD, Alkynylnorleucine (Norleucine conjugated to an alkyne 
       group (Nle(epsilon-alkyne))), or Lys conjugated  to 
       PEG2-C5-alkyne, PEG2PEG2-C5-alkyne, or 
       

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Xaa is Glutamine, Nle(epsilon-alkyne), or Lysine conjugated to 
       PEG2PEG2-gamma-Glu-C16-alkyne

<220>
<221>  MISC_FEATURE
<222>  (25)..(25)
<223>  Xaa is Tryptophan or alpha-methyl Tryptophan (alpha-MW)

<220>
<221>  MISC_FEATURE
<222>  (26)..(26)
<223>  Xaa is Leucine or alpha-ML

<220>
<221>  MISC_FEATURE
<222>  (27)..(27)
<223>  Xaa is Leucine or L-methionine sulphone (2)

<220>
<221>  MISC_FEATURE
<222>  (28)..(28)
<223>  Xaa is Aspartic acid, Alanine, Lysine, Asparagine, gamma-Glu, 
       Glutamine, or alpha-MD

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  Xaa is Threonine or Glycine

<220>
<221>  MISC_FEATURE
<222>  (30)..(30)
<223>  Xaa is Arginine, Lysine, or Nle(epsilon-alkyne), or Xaa is absent
       and

<220>
<221>  MISC_FEATURE
<222>  (31)..(31)
<223>  Xaa is Glycine, gamma-Glu, Nle(epsilon-alkyne), or Lysine 
       conjugated via its epsilon amine group to 
       PEG2PEG2-gamma-Glu-C16-alkyne, PEG2-C5-alkyne, 
       PEG2PEG2-C5-alkyne, or Xaa is absent

<400>  13

His Xaa Xaa Gly Thr Phe Thr Ser Xaa Xaa Ser Xaa Tyr Xaa Asp Xaa 
1               5                   10                  15      


Xaa Xaa Ala Xaa Xaa Phe Val Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            20                  25                  30      


<210>  14
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is Tyrosine, Phenylalanine, Tryptophan, or other amino acid 
       with an aromatic group

<220>
<221>  PEPTIDE
<222>  (1)..(31)
<223>  C-terminal amino acid optionally is linked to a protecting group 
       or amidated

<220>
<221>  PEPTIDE
<222>  (1)..(31)
<223>  with the proviso that either X10 is a Lysine residue conjugated 
       to a gamma-Glu-gamma-Glu-C16 and one of X20, X21, X24, X30, or 
       X31 comprises the azide or N3 group or X20 is a Lysine residue 
       conjugated to the PEG2PEG2-gamma-Glu-C18-OH or

<220>
<221>  PEPTIDE
<222>  (1)..(31)
<223>  the PEG2PEG2gamma-E-C20-OH and one of  X21, X24, X30, or X31 
       comprises the azide or N3 group

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is aminoisobutyric acid (Aib), D-Serine (s), or alpha-methyl 
       Serine (alpha-MS)

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is Glu or Asp

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa is Serine or alpha-methyl Aspartic acid (alpha-MD)

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa is Tyr or Lys conjugated to gamma-Glu-gamma-Glu-C16

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Xaa is Isoleucine, Lysine, Leucine, or Serine

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa is Leu of alpha-methyl Leucine (alpha-ML)

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa is Glutamic acid, Asparagine, Serine, Alanine, or Aib

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  Xaa is Arginine or Lysine

<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  Xaa is Alanine or Arginine

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  Xaa is Glutamine or Lysine conjugated via its epsilon amine group
       to PEG2-C5N3, PEG2PEG2-C5N3, PEG2PEG2-gamma-Glu-C16N3, 
       PEG2PEG2-gamma-Glu-C18-OH, or PEG2PEG2gamma-E-C20-OH

<220>
<221>  MISC_FEATURE
<222>  (21)..(21)
<223>  Xaa is Aspartic acid, alpha-methyl Phenylalanine (alpha-MF), 
       alpha-MD, Azidonorleucine (Norleucine conjugated via its epsilon 
       carbon to an azide group (Nle(epsilon-N3))), or Lys conjugated  
       to PEG2-C5N3 , PEG2PEG2-C5N3, or PEG2PEG2-gamma-Glu-C16N3

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Xaa is Glutamine, Nle(epsilon-N3), or Lysine conjugated to 
       PEG2PEG2-gamma-Glu-C16N3

<220>
<221>  MISC_FEATURE
<222>  (25)..(25)
<223>  Xaa is Tryptophan or alpha-methyl Tryptophan (alpha-MW)

<220>
<221>  MISC_FEATURE
<222>  (26)..(26)
<223>  Xaa is Leucine or alpha-ML

<220>
<221>  MISC_FEATURE
<222>  (27)..(27)
<223>  Xaa is Leucine or L-methionine sulphone (2)

<220>
<221>  MISC_FEATURE
<222>  (28)..(28)
<223>  Xaa is Aspartic acid, Alanine, Lysine, Asparagine, gamma-Glu, 
       Glutamine, or alpha-MD

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  Xaa is Threonine or Glycine

<220>
<221>  MISC_FEATURE
<222>  (30)..(30)
<223>  Xaa is Arginine, Lysine, or Nle(epsilon-N3), or Xaa is absent

<220>
<221>  MISC_FEATURE
<222>  (31)..(31)
<223>  Xaa is Glycine, gamma-Glu, Nle(epsilon-N3), or Lysine conjugated 
       via its epsilon amine group to PEG2PEG2-gamma-Glu-C16N3 , 
       PEG2-C5N3 or PEG2PEG2-C5N3, or Xaa is absent

<400>  14

Xaa Xaa Xaa Gly Thr Phe Thr Ser Xaa Xaa Ser Xaa Tyr Xaa Asp Xaa 
1               5                   10                  15      


Xaa Xaa Ala Xaa Xaa Phe Val Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            20                  25                  30      


<210>  15
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is Tyrosine, Phenylalanine, Tryptophan, or other amino acid 
       with an aromatic group

<220>
<221>  PEPTIDE
<222>  (1)..(31)
<223>  wherein the C-terminal amino acid optionally is amidated

<220>
<221>  PEPTIDE
<222>  (1)..(31)
<223>  C-terminal amino acid optionally is linked to a protecting group 
       or amidated

<220>
<221>  PEPTIDE
<222>  (1)..(31)
<223>  with the proviso that either X10 is a Lysine residue conjugated 
       to a gamma-Glu-gamma-Glu-C16 and one of X20, X21, X24, X30, or 
       X31 comprises the -alkyne or X20 is a Lysine residue conjugated 
       to the PEG2PEG2-gamma-Glu-C18-OH or

<220>
<221>  PEPTIDE
<222>  (1)..(31)
<223>  the PEG2PEG2gamma-E-C20-OH and one of  X21, X24, X30, or X31 
       comprises the -alkyne

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is aminoisobutyric acid (Aib), D-Serine (s), or alpha-methyl 
       Serine (alpha-MS)

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is Glu or Asp

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa is Serine or alpha-methyl Aspartic acid (alpha-MD)

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa is Tyr or Lys conjugated to gamma-Glu-gamma-Glu-C16

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Xaa is Isoleucine, Lysine, Leucine, or Serine

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa is Leu of alpha-methyl Leucine (alpha-ML)

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa is Glutamic acid, Asparagine, Serine, Alanine, or Aib

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  Xaa is Arginine or Lysine

<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  Xaa is Alanine or Arginine

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  Xaa is Glutamine or Lysine conjugated via its epsilon amine group
       to PEG2-C5N3, PEG2PEG2-C5-alkyne, PEG2PEG2-gamma-Glu-C16-alkyne, 
       PEG2PEG2-gamma-Glu-C18-OH, or PEG2PEG2gamma-E-C20-OH

<220>
<221>  MISC_FEATURE
<222>  (21)..(21)
<223>  Xaa is Aspartic acid, alpha-methyl Phenylalanine (alpha-MF), 
       alpha-MD, Alkynylnorleucine (Norleucine conjugated  to an alkyne 
       group (Nle(epsilon-alkyne))), or Lys conjugated to 
       PEG2-C5-alkyne, PEG2PEG2-C5-alkyne, or PEG2PEG2-gamma-Glu-C16 
       

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Xaa is Glutamine, Nle(epsilon-alkyne), or Lysine conjugated to 
       PEG2PEG2-gamma-Glu-C16-alkyne

<220>
<221>  MISC_FEATURE
<222>  (25)..(25)
<223>  Xaa is Tryptophan or alpha-methyl Tryptophan (alpha-MW)

<220>
<221>  MISC_FEATURE
<222>  (26)..(26)
<223>  Xaa is Leucine or alpha-ML

<220>
<221>  MISC_FEATURE
<222>  (27)..(27)
<223>  Xaa is Leucine or L-methionine sulphone (2)

<220>
<221>  MISC_FEATURE
<222>  (28)..(28)
<223>  Xaa is Aspartic acid, Alanine, Lysine, Asparagine, gamma-Glu, 
       Glutamine, or alpha-MD

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  Xaa is Threonine or Glycine

<220>
<221>  MISC_FEATURE
<222>  (30)..(30)
<223>  Xaa is Arginine, Lysine, or Nle(epsilon-alkyne), or Xaa is absent
       and

<220>
<221>  MISC_FEATURE
<222>  (31)..(31)
<223>  Xaa is Glycine, gamma-Glu, Nle(epsilon-alkyne), or Lysine 
       conjugated via its epsilon amine group to 
       PEG2PEG2-gamma-Glu-C16-alkyne, PEG2-C5-alkyne, 
       PEG2PEG2-C5-alkyne, or Xaa is absent

<400>  15

Xaa Xaa Xaa Gly Thr Phe Thr Ser Xaa Xaa Ser Xaa Tyr Xaa Asp Xaa 
1               5                   10                  15      


Xaa Xaa Ala Xaa Xaa Phe Val Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            20                  25                  30      


<210>  16
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is Tyrosine, Phenylalanine, Tryptophan, or other amino acid 
       with an aromatic group

<220>
<221>  PEPTIDE
<222>  (1)..(31)
<223>  C-terminal amino acid optionally is linked to a protecting group 
       or amidated

<220>
<221>  PEPTIDE
<222>  (1)..(31)
<223>  with the proviso that either X10 is a Lysine residue conjugated 
       to a gamma-Glu-gamma-Glu-C16 and one of X20, X21, X24, X30, or 
       X31 comprises the azide or N3 group or X20 is a Lysine residue 
       conjugated to the PEG2PEG2-gamma-Glu-C18-OH or

<220>
<221>  PEPTIDE
<222>  (1)..(31)
<223>  the PEG2PEG2gamma-E-C20-OH and one of  X21, X24, X30, or X31 
       comprises the azide or N3 group

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is aminoisobutyric acid (Aib), D-Serine (s), or alpha-methyl 
       Serine (alpha-MS)

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa is Serine or alpha-methyl Aspartic acid (alpha-MD)

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa is Tyr or Lys conjugated to gamma-Glu-gamma-Glu-C16

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Xaa is Isoleucine, Lysine, Leucine, or Serine

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa is Leu of alpha-methyl Leucine (alpha-ML)

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa is Glutamic acid, Asparagine, Serine, Alanine, or Aib

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  Xaa is Arginine or Lysine

<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  Xaa is Alanine or Arginine

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  X20 is Glutamine or Lysine conjugated via its epsilon amine group
       to PEG2-C5N3, PEG2PEG2-C5N3, PEG2PEG2-gamma-Glu-C16N3, 
       PEG2PEG2-gamma-Glu-C18-OH, or PEG2PEG2gamma-E-C20-OH

<220>
<221>  MISC_FEATURE
<222>  (21)..(21)
<223>  Xaa is Aspartic acid, alpha-methyl Phenylalanine (alpha-MF), 
       alpha-MD, Azidonorleucine (Norleucine conjugated via its epsilon 
       carbon to an azide group (Nle(epsilon-N3))), or Lys conjugated  
       to PEG2-C5N3 , PEG2PEG2-C5N3, or PEG2PEG2-gamma-Glu-C16N3

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Xaa is Glutamine, Nle(epsilon-N3), or Lysine conjugated to 
       PEG2PEG2-gamma-Glu-C16N3

<220>
<221>  MISC_FEATURE
<222>  (25)..(25)
<223>  Xaa is Tryptophan or alpha-methyl Tryptophan (alpha-MW)

<220>
<221>  MISC_FEATURE
<222>  (26)..(26)
<223>  Xaa is Leucine or alpha-ML

<220>
<221>  MISC_FEATURE
<222>  (27)..(27)
<223>  Xaa is Leucine or L-methionine sulphone (2)

<220>
<221>  MISC_FEATURE
<222>  (28)..(28)
<223>  Xaa is Aspartic acid, Alanine, Lysine, Asparagine, gamma-Glu, 
       Glutamine, or alpha-MD

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  Xaa is Threonine or Glycine

<220>
<221>  MISC_FEATURE
<222>  (30)..(30)
<223>  Xaa is Arginine, Lysine, or Nle(epsilon-N3), or Xaa is absent

<220>
<221>  MISC_FEATURE
<222>  (31)..(31)
<223>  Xaa is Glycine, gamma-Glu, Nle(epsilon-N3), or Lysine conjugated 
       via its epsilon amine group to PEG2PEG2-gamma-Glu-C16N3 , 
       PEG2-C5N3 or PEG2PEG2-C5N3, or Xaa is absent

<400>  16

Xaa Xaa Gln Gly Thr Phe Thr Ser Xaa Xaa Ser Xaa Tyr Xaa Asp Xaa 
1               5                   10                  15      


Xaa Xaa Ala Xaa Xaa Phe Val Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            20                  25                  30      


<210>  17
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is Tyrosine, Phenylalanine, Tryptophan, or other amino acid 
       with an aromatic group

<220>
<221>  PEPETIDE
<222>  (1)..(31)
<223>  C-terminal amino acid optionally is linked to a protecting group 
       or amidated

<220>
<221>  PEPETIDE
<222>  (1)..(31)
<223>  with the proviso that either X10 is a Lysine residue conjugated 
       to a gamma-Glu-gamma-Glu-C16 and one of X20, X21, X24, X30, or 
       X31 comprises the -alkyne or X20 is a Lysine residue conjugated 
       to the PEG2PEG2-gamma-Glu-C18-OH or

<220>
<221>  PEPETIDE
<222>  (1)..(31)
<223>  the PEG2PEG2gamma-E-C20-OH and one of  X21, X24, X30, or X31

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is aminoisobutyric acid (Aib), D-Serine (s), or alpha-methyl 
       Serine (alpha-MS)

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa is Serine or alpha-methyl Aspartic acid (alpha-MD)

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa is Tyr or Lys conjugated to gamma-Glu-gamma-Glu-C16

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Xaa is Isoleucine, Lysine, Leucine, or Serine

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa is Leu of alpha-methyl Leucine (alpha-ML)

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa is Glutamic acid, Asparagine, Serine, Alanine, or Aib

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  Xaa is Arginine or Lysine

<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  Xaa is Alanine or Arginine

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  Xaa is Glutamine or Lysine conjugated via its epsilon amine group
       to PEG2-C5N3, PEG2PEG2-C5-alkyne, PEG2PEG2-gamma-Glu-C16-alkyne, 
       PEG2PEG2-gamma-Glu-C18-OH, or PEG2PEG2gamma-E-C20-OH

<220>
<221>  MISC_FEATURE
<222>  (21)..(21)
<223>  Xaa is Asp, alpha-methyl Phenylalanine (alpha-MF), alpha-MD, 
       Alkynylnorleucine (Norleucine conjugated via its epsilon carbon 
       to an alkyne group (Nle(epsilon-alkyne))), or Lys conjugated to 
       PEG2-C5-alkyne, PEG2PEG2-C5-alkyne, or 
       

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Xaa is Glutamine, Nle(epsilon-alkyne), or Lysine conjugated to 
       PEG2PEG2-gamma-Glu-C16-alkyne

<220>
<221>  MISC_FEATURE
<222>  (25)..(25)
<223>  Xaa is Tryptophan or alpha-methyl Tryptophan (alpha-MW)

<220>
<221>  MISC_FEATURE
<222>  (26)..(26)
<223>  Xaa is Leucine or alpha-ML

<220>
<221>  MISC_FEATURE
<222>  (27)..(27)
<223>  Xaa is Leucine or L-methionine sulphone (2)

<220>
<221>  MISC_FEATURE
<222>  (28)..(28)
<223>  Xaa is Aspartic acid, Alanine, Lysine, Asparagine, gamma-Glu, 
       Glutamine, or alpha-MD

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  Xaa is Threonine or Glycine

<220>
<221>  MISC_FEATURE
<222>  (30)..(30)
<223>  Xaa is Arginine, Lysine, or Nle(epsilon-alkyne), or Xaa is absent

<220>
<221>  MISC_FEATURE
<222>  (31)..(31)
<223>  X31 is Glycine, gamma-Glu, Nle(epsilon-alkyne), or Lysine 
       conjugated via its epsilon amine group to 
       PEG2PEG2-gamma-Glu-C16-alkyne, PEG2-C5-alkyne, 
       PEG2PEG2-C5-alkyne, or Xaa is absent

<400>  17

Xaa Xaa Gln Gly Thr Phe Thr Ser Xaa Xaa Ser Xaa Tyr Xaa Asp Xaa 
1               5                   10                  15      


Xaa Xaa Ala Xaa Xaa Phe Val Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            20                  25                  30      


<210>  18
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide


<220>
<221>  PEPTIDE
<222>  (1)..(32)
<223>  with the proviso that only one of X10, X20, X21, or X28, or X29 
       is Nle(epsilon-N3) or Lysine conjugated via its epsilon amine 
       group to PEG2PEG2-gamma-Glu-C16- N3, PEG2-C5- N3, PEG2PEG2-C5- N3

<220>
<221>  PEPTIDE
<222>  (1)..(32)
<223>  C-terminal amino acid optionally is linked to a protecting group 
       or amidated

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa is Valine, Nle(epsilon-N3), or Lysine conjugated via its 
       epsilon amine group to PEG2PEG2-gamma-Glu-C16- N3, PEG2-C5- N3, 
       or PEG2PEG2-C5- N3

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  Xaa is Lysine, Nle(epsilon-N3), or Lysine conjugated via its 
       epsilon amine group to PEG2PEG2-gamma-Glu-C16- N3, PEG2-C5- N3, 
       or PEG2PEG2-C5- N3

<220>
<221>  MISC_FEATURE
<222>  (21)..(21)
<223>  Xaa is glutamic acid, Nle(epsilon-N3), or Lysine conjugated via 
       its epsilon amine group to PEG2PEG2-gamma-Glu-C16- N3, PEG2-C5- 
       N3, or PEG2PEG2-C5- N3

<220>
<221>  MISC_FEATURE
<222>  (28)..(28)
<223>  Xaa is Lysine, Nle(epsilon-N3), or Lysine conjugated via its 
       epsilon amine group to PEG2PEG2-gamma-Glu-C16- N3, PEG2-C5- N3, 
       or PEG2PEG2-C5- N3

<220>
<221>  MISC_FEATURE
<222>  (32)..(32)
<223>  Xaa Nle(epsilon-N3), or Lysine conjugated via its epsilon amine 
       group to PEG2PEG2-gamma-Glu-C16- N3, PEG2-C5- N3, PEG2PEG2-C5- N3
       or absent

<400>  18

His Gly Glu Gly Thr Phe Thr Ser Asp Xaa Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Xaa Xaa Phe Ile Ala Trp Leu Val Xaa Gly Gly Gly Xaa 
            20                  25                  30          


<210>  19
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide


<220>
<221>  PEPTIDE
<222>  (1)..(32)
<223>  with the proviso that only one of X10, X20, X21, or X28, or X29 
       is Nle(epsilon-N3) or Lysine conjugated via its epsilon amine 
       group to PEG2PEG2-gamma-Glu-C16-alkyne, PEG2-C5-alkyne, 
       PEG2PEG2-C5-alkyne

<220>
<221>  PEPTIDE
<222>  (1)..(32)
<223>  C-terminal amino acid optionally is linked to a protecting group 
       or amidated

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa is Valine, Nle(epsilon-alkyne), or Lysine conjugated via its 
       epsilon amine group to PEG2PEG2-gamma-Glu-C16-alkyne, 
       PEG2-C5-alkyne, or PEG2PEG2-C5-alkyne

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  Xaa is Lysine, Nle(epsilon-N3), or Lysine conjugated via its 
       epsilon amine group to PEG2PEG2-gamma-Glu-C16-alkyne, 
       PEG2-C5-alkyne, or PEG2PEG2-C5-alkyne

<220>
<221>  MISC_FEATURE
<222>  (21)..(21)
<223>  Xaa is glutamic acid, Nle(epsilon-alkyne), or Lysine conjugated 
       via its epsilon amine group to PEG2PEG2-gamma-Glu-C16-alkyne, 
       PEG2-C5-alkyne, or PEG2PEG2-C5-alkyne

<220>
<221>  MISC_FEATURE
<222>  (28)..(28)
<223>  Xaa is Lysine, Nle(epsilon-alkyne), or Lysine conjugated via its 
       epsilon amine group to PEG2PEG2-gamma-Glu-C16-alkyne, 
       PEG2-C5-alkyne, or PEG2PEG2-C5-alkyne

<220>
<221>  MISC_FEATURE
<222>  (32)..(32)
<223>  Xaa Nle(epsilon-alkyne), or Lysine conjugated via its epsilon 
       amine group to PEG2PEG2-gamma-Glu-C16-alkyne, PEG2-C5-alkyne, 
       PEG2PEG2-C5-alkyne or absent

<400>  19

His Gly Glu Gly Thr Phe Thr Ser Asp Xaa Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Xaa Xaa Phe Ile Ala Trp Leu Val Xaa Gly Gly Gly Xaa 
            20                  25                  30          


<210>  20
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is His, Phe, or Tyr

<220>
<221>  PEPTIDE
<222>  (1)..(29)
<223>  C-terminal amino acid optionally is linked to a protecting group 
       or amidated

<220>
<221>  PEPTIDE
<222>  (1)..(29)
<223>  with provisio that peptide comprises only one Nle(eN3)

<220>
<221>  PEPTIDE
<222>  (1)..(29)
<223>  optionally the peptide includes a C-terminal extension selected 
       from the group consisting of KK(PEG2PEG2)-C5N3, KQ-Nle(eN3), SEQ 
       ID NO:21, RG-Nle(eN3), SEQ ID NO:22, SEQ ID NO:23, Nle(eN3), KSEQ
       ID NO:24), and SEQ ID NO:25 linked to the amino acid at 29

<220>
<221>  PEPTIDE
<222>  (1)..(29)

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is amionisobutyric acid (Aib), Gly, Ala, Ser, D-Serine (s)

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is Glu or Gln

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa is Tyr

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa is Asp or Lys

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa is Tyr, Val, Leu, or Lys

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa is Ser or Val

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Xaa is Lysine, Iso, or Serine

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  Xaa is Gln, Ala, or Tyr

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa is Leu, Met, or met sulphone

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  Xaa is Glu or Asp

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa is Glu, Asn, Ser, Ala, or Aib

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  Xaa is Glu, Iso, Gln, or Arg

<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  Xaa is Ala, His, or Arg

<220>
<221>  MISC_FEATURE
<222>  (19)..(19)
<223>  Xaa is Val, Gln, or Ala

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  Xaa is Arg, Lys, Gln, or Aib

<220>
<221>  MISC_FEATURE
<222>  (21)..(21)
<223>  Xaa is Leu, Glu, or Asp

<220>
<221>  MISC_FEATURE
<222>  (23)..(23)
<223>  Xaa is Iso or Val

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Xaa is Glu, Ala, Gln, Nle(epsilon-N3), or Lysine conjugated via 
       its epsilon amino group to aPEG2PEG2-gamma-Glu-C16N3

<220>
<221>  MISC_FEATURE
<222>  (27)..(27)
<223>  Xaa is Lys, Val, Met, Nle(epsilonN3), or Nle

<220>
<221>  MISC_FEATURE
<222>  (28)..(28)
<223>  Xaa is Asp, Arg, Lys, Ala, or Asn

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  Xaa is Gly, Tyr, Gln, or Gly

<400>  20

Xaa Xaa Xaa Gly Thr Phe Xaa Ser Xaa Xaa Ser Xaa Tyr Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Phe Xaa Xaa Trp Leu Xaa Xaa Xaa 
            20                  25                  


<210>  21
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C-terminal extension


<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa is Nle(epsilon-N3)

<400>  21

Gly Pro Ser Ser Gly Ala Pro Pro Pro Ser Xaa 
1               5                   10      


<210>  22
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C-terminal Extension


<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa is Nle(epsilon-N3)

<400>  22

Gly Pro Ser Ser Gly Ala Pro Pro Ser Lys Lys Lys Lys Lys Lys Xaa 
1               5                   10                  15      


<210>  23
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C-terminal extension


<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa is Nle(epsilon-N3)

<400>  23

Gly Gly Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Ala Xaa 
1               5                   10                  15      


<210>  24
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C-terminal extension


<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa is Nle(epsilon-N3)

<400>  24

Lys Gly Leu Leu Asn Asp Trp Lys His Asn Ile Thr Gln Xaa 
1               5                   10                  


<210>  25
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C-terminal extension


<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa is Nle(epsilon-N3)

<400>  25

Lys Arg Asn Lys Asn Asn Ile Ala Xaa 
1               5                   


<210>  26
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C-terminal extension

<400>  26

Lys Arg Asn Lys Asn Asn Ile Ala 
1               5               


<210>  27
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C-terminal extension

<400>  27

Gly Pro Ser Ser Gly Ala Pro Pro Pro Ser 
1               5                   10  


<210>  28
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C-terminal extension

<400>  28

Gly Pro Ser Ser Gly Ala Pro Pro Ser Lys Lys Lys Lys Lys Lys 
1               5                   10                  15  


<210>  29
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C-terminal extension

<400>  29

Gly Gly Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Ala 
1               5                   10                  15  


<210>  30
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C-terminal extension

<400>  30

Lys Gly Leu Leu Asn Asp Trp Lys His Asn Ile Thr Gln 
1               5                   10              


<210>  31
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is His, Phe, or Tyr

<220>
<221>  PEPTIDE
<222>  (1)..(29)
<223>  wherein the C-terminal amino acid optionally linked to a 
       protecting group or amidated

<220>
<221>  PEPTIDE
<222>  (1)..(29)
<223>  the peptide includes a C-terminal extension selected from the 
       group consisting of KK(PEG2PEG2)-C5N3, KQ-Nle(eN3), SEQ ID NO:21,
       RG-Nle(eN3), SEQ ID NO:22, SEQ ID NO:23, Nle(eN3), KSEQ ID 
       NO:24), and SEQ ID NO:25 linked to the amino acid at 29

<220>
<221>  PEPTIDE
<222>  (1)..(29)
<223>  with proviso peptide comprises only one Nle(eN3)

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is amionisobutyric acid (Aib), Gly, Ala, Ser, D-Serine (s)

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is Glu or Gln

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa is Tyr

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa is Asp or Lys

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa is Tyr, Val, Leu, or Lys

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa is Ser or Val

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Xaa is Lysine, Iso, or Serine

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  Xaa is Gln, Ala, or Tyr

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa is Leu, Met, or met sulphone

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  Xaa is Glu or Asp

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa is Glu, Asn, Ser, Ala, or Aib

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  Xaa is Glu, Iso, Gln, or Arg

<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  Xaa is Ala, His, or Arg

<220>
<221>  MISC_FEATURE
<222>  (19)..(19)
<223>  Xaa is Val, Gln, or Ala

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  Xaa is Arg, Lys, Gln, or Aib

<220>
<221>  MISC_FEATURE
<222>  (21)..(21)
<223>  Xaa is Leu, Glu, or Asp

<220>
<221>  MISC_FEATURE
<222>  (23)..(23)
<223>  Xaa is Iso or Val

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Xaa is Glu, Ala, Gln, Nle(epsilon-N3), or Lysine conjugated via 
       its epsilon amino group to aPEG2PEG2-gamma-Glu-C16N3

<220>
<221>  MISC_FEATURE
<222>  (27)..(27)
<223>  Xaa is Lys, Val, Met, Nle(epsilonN3), or Nle

<220>
<221>  MISC_FEATURE
<222>  (28)..(28)
<223>  Xaa is Asp, Arg, Lys, Ala, or Asn

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  Xaa is Gly, Tyr, Gln, or Gly

<400>  31

Xaa Xaa Xaa Gly Thr Phe Xaa Ser Xaa Xaa Ser Xaa Tyr Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Phe Xaa Xaa Trp Leu Xaa Xaa Xaa 
            20                  25                  


<210>  32

<400>  32
000

<210>  33

<400>  33
000

<210>  34

<400>  34
000

<210>  35
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide


<220>
<221>  PEPTIDE
<222>  (1)..(29)
<223>  C-terminal amide

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa2 is D-Ser

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Lys10 conjugated to  gamma-Glu-gamma-Glu-C16

<220>
<221>  MISC_FEATURE
<222>  (21)..(21)
<223>  Xaa21 is Nle(epsilon-N3)

<400>  35

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Gln Xaa Phe Val Gln Trp Leu Leu Asp Thr 
            20                  25                  


<210>  36
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide


<220>
<221>  PEPTIDE
<222>  (1)..(31)
<223>  C-terminal amide

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa2 is aib

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Lys10 conjugated to  gamma-Glu-gamma-Glu-C16

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Xaa24 is Nle(epsilon-N3)

<400>  36

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Xaa Trp Leu Leu Asp Gly Arg Gly 
            20                  25                  30      


<210>  37
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide


<220>
<221>  PEPTIDE
<222>  (1)..(31)

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa2 is aib

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Lys10 conjugated to  gamma-Glu-gamma-Glu-C16

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa16 is aib

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Xaa24 is Nle(epsilon-N3)

<220>
<221>  MISC_FEATURE
<222>  (27)..(27)
<223>  Xaa27 is methione sulfone

<400>  37

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Xaa Trp Leu Xaa Lys Gly Arg Gly 
            20                  25                  30      


<210>  38
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide


<220>
<221>  PEPTIDE
<222>  (1)..(31)
<223>  C-terminal amide

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa2 is D-Ser

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Lys10 conjugated to  gamma-Glu-gamma-Glu-C16

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa16 is aib

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Xaa24 is Nle(epsilon-N3)

<220>
<221>  MISC_FEATURE
<222>  (31)..(31)
<223>  Xaa31 is gamma-Glu

<400>  38

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Leu Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Xaa Trp Leu Leu Asn Thr Lys Xaa 
            20                  25                  30      


<210>  39
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide


<220>
<221>  PEPTIDE
<222>  (1)..(31)
<223>  C-terminal amide

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa2 is D-Ser

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Lys10 conjugated to  gamma-Glu-gamma-Glu-C16

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa16 is aib

<220>
<221>  MISC_FEATURE
<222>  (30)..(30)
<223>  Xaa30 is Nle(epsilon-N3)

<220>
<221>  MISC_FEATURE
<222>  (31)..(31)
<223>  Xaa31 is  gamma-Glu

<400>  39

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Leu Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Gln Trp Leu Leu Asn Thr Xaa Xaa 
            20                  25                  30      


<210>  40
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide


<220>
<221>  PEPTIDE
<222>  (1)..(31)
<223>  C-terminal amide

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa2 is aib

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Lys10 conjugated to  gamma-Glu-gamma-Glu-C16

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa16 is aib

<220>
<221>  MISC_FEATURE
<222>  (30)..(30)
<223>  Xaa30 is Nle(epsilon-N3)

<220>
<221>  MISC_FEATURE
<222>  (31)..(31)
<223>  Xaa31 is  gamma-Glu

<400>  40

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Leu Asp Thr Xaa Xaa 
            20                  25                  30      


<210>  41
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide


<220>
<221>  PEPTIDE
<222>  (1)..(29)
<223>  C-terminal amide

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa2 is D-Ser

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Lys10 conjugated to  gamma-Glu-gamma-Glu-C16

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa16 is aib

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Xaa24 is Nle(epsilon-N3)

<400>  41

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Xaa Trp Leu Leu Asp Thr 
            20                  25                  


<210>  42
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide


<220>
<221>  PEPTIDE
<222>  (1)..(31)
<223>  C-terminal amide

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa2 is D-Ser

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Lys10 conjugated to  gamma-Glu-gamma-Glu-C16

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa16 is aib

<220>
<221>  MISC_FEATURE
<222>  (30)..(30)
<223>  Xaa30 is Nle(epsilon-N3)

<220>
<221>  MISC_FEATURE
<222>  (31)..(31)
<223>  Xaa31 is  gamma-Glu

<400>  42

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Ser Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Gln Trp Leu Leu Asn Thr Xaa Xaa 
            20                  25                  30      


<210>  43
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide


<220>
<221>  PEPTIDE
<222>  (1)..(31)
<223>  C-terminal amide

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa2 is D-Ser

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Lys10 conjugated to  gamma-Glu-gamma-Glu-C16

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa16 is aib

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Xaa24 is Nle(epsilon-N3)

<400>  43

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Ser Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Xaa Trp Leu Leu Asn Thr Lys Xaa 
            20                  25                  30      


<210>  44
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide


<220>
<221>  PEPTIDE
<222>  (1)..(29)
<223>  C-terminal amide

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa2 is aib

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Lys10 conjugated to  gamma-Glu-gamma-Glu-C16

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa16 is aib

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Xaa24 is Nle(epsilon-N3)

<220>
<221>  MISC_FEATURE
<222>  (27)..(27)
<223>  Xaa27 is methione sulfone

<400>  44

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Xaa Trp Leu Xaa Asp Thr 
            20                  25                  


<210>  45
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide


<220>
<221>  PEPTIDE
<222>  (1)..(29)
<223>  C-terminal amide

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa2 is D-Ser

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Lys10 conjugated to  gamma-Glu-gamma-Glu-C16

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Xaa24 is Nle(epsilon-N3)

<400>  45

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Xaa Trp Leu Leu Xaa Thr 
            20                  25                  


<210>  46
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide


<220>
<221>  PEPTIDE
<222>  (1)..(29)
<223>  C-terminal amide

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa2 is D-Ser

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Lys10 conjugated to  gamma-Glu-gamma-Glu-C16

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Xaa24 is Nle(epsilon-N3)

<400>  46

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Asn 
1               5                   10                  15      


Lys Arg Ala Gln Asp Phe Val Xaa Trp Leu Leu Gln Thr 
            20                  25                  


<210>  47
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide


<220>
<221>  PEPTIDE
<222>  (1)..(29)
<223>  C-terminal amide

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa2 is D-Ser

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Lys10 conjugated to  gamma-Glu-gamma-Glu-C16

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Xaa24 is Nle(epsilon-N3)

<400>  47

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala His Asp Phe Val Xaa Trp Leu Leu Asn Thr 
            20                  25                  


<210>  48
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide


<220>
<221>  PEPTIDE
<222>  (1)..(29)
<223>  C-terminal amide

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa2 is D-Ser

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Lys10 conjugated to  gamma-Glu-gamma-Glu-C16

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Lys24 is conjugated to  PEG2-C5N3

<400>  48

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Lys Trp Leu Leu Asp Thr 
            20                  25                  


<210>  49
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide


<220>
<221>  PEPTIDE
<222>  (1)..(29)
<223>  C-terminal amide

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa2 is D-Ser

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Lys10 conjugated to  gamma-Glu-gamma-Glu-C16

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Lys24 is conjugated to  PEG2PEG2-C5N3

<400>  49

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Lys Trp Leu Leu Asp Thr 
            20                  25                  


<210>  50
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide


<220>
<221>  PEPTIDE
<222>  (1)..(29)
<223>  C-terminal amide

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa2 is D-Ser

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Lys10 conjugated to  gamma-Glu-gamma-Glu-C16

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  Lys20 is conjugated to  PEG2-C5N3

<400>  50

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Leu Asp Thr 
            20                  25                  


<210>  51
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide


<220>
<221>  PEPTIDE
<222>  (1)..(29)
<223>  C-terminal amide

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa2 is D-Ser

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Lys10 conjugated to  gamma-Glu-gamma-Glu-C16

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  Lys20 is conjugated to  PEG2PEG2-C5N3

<400>  51

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Leu Asp Thr 
            20                  25                  


<210>  52
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide


<220>
<221>  PEPTIDE
<222>  (1)..(31)
<223>  C-terminal amide

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa2 is aib

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa16 is aib

<220>
<221>  MISC_FEATURE
<222>  (31)..(31)
<223>  Xaa31 is Nle(epsilon-N3)

<400>  52

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Gln Trp Leu Leu Asp Thr Lys Xaa 
            20                  25                  30      


<210>  53
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide


<220>
<221>  PEPTIDE
<222>  (1)..(31)
<223>  C-terminal amide

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa2 is aib

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Lys10 conjugated to  gamma-Glu-gamma-Glu-C16

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa16 is aib

<220>
<221>  MISC_FEATURE
<222>  (31)..(31)
<223>  Xaa31 is Nle(epsilon-N3)

<400>  53

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Gln Trp Leu Leu Asp Thr Lys Xaa 
            20                  25                  30      


<210>  54
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide


<220>
<221>  PEPTIDE
<222>  (1)..(31)
<223>  C-terminal amide

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa2 is aib

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Lys10 conjugated to  gamma-Glu-gamma-Glu-C16

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa16 is aib

<220>
<221>  MISC_FEATURE
<222>  (31)..(31)
<223>  K31 conjugated to  PEG2-C5N3

<400>  54

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Gln Trp Leu Leu Asp Thr Lys Lys 
            20                  25                  30      


<210>  55
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide


<220>
<221>  PEPTIDE
<222>  (1)..(31)
<223>  C-terminal amide

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa2 is aib

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Lys10 conjugated to  gamma-Glu-gamma-Glu-C16

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa16 is aib

<220>
<221>  MISC_FEATURE
<222>  (31)..(31)
<223>  Lys31 is conjugated to  PEG2PEG2-C5N3

<400>  55

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Gln Trp Leu Leu Asp Thr Lys Lys 
            20                  25                  30      


<210>  56
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide


<220>
<221>  PEPTIDE
<222>  (1)..(31)
<223>  C-terminal amide

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa2 is aib

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Lys10 conjugated to  gamma-Glu-gamma-Glu-C16

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa16 is aib

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Xaa24 is Nle(epsilon-N3)

<220>
<221>  MISC_FEATURE
<222>  (31)..(31)
<223>  X31 is gamma-Glu

<400>  56

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Xaa Trp Leu Leu Asp Thr Lys Xaa 
            20                  25                  30      


<210>  57
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide


<220>
<221>  PEPTIDE
<222>  (1)..(29)
<223>  C-terminal amide

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa2 is D-Ser

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Lys10 conjugated to  gamma-Glu-gamma-Glu-C16

<220>
<221>  MISC_FEATURE
<222>  (21)..(21)
<223>  Xaa21 is Nle(epsilon-N3)

<220>
<221>  MISC_FEATURE
<222>  (27)..(27)
<223>  Xaa27 is methione sulfone

<400>  57

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Gln Xaa Phe Val Gln Trp Leu Xaa Asp Thr 
            20                  25                  


<210>  58
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide


<220>
<221>  PEPTIDE
<222>  (1)..(29)
<223>  C-terminal amide

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa2 is D-Ser

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Lys10 conjugated to  gamma-Glu-gamma-Glu-C16

<220>
<221>  MISC_FEATURE
<222>  (21)..(21)
<223>  Xaa21 is Nle(epsilon-N3)

<220>
<221>  MISC_FEATURE
<222>  (27)..(27)
<223>  Xaa27 is methione sulfone

<220>
<221>  MISC_FEATURE
<222>  (28)..(28)
<223>  Xaa28 is alpha-MD

<400>  58

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Gln Xaa Phe Val Gln Trp Leu Xaa Xaa Thr 
            20                  25                  


<210>  59
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide


<220>
<221>  PEPTIDE
<222>  (1)..(29)
<223>  C-terminal amide

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa2 is D-Ser

<220>
<221>  MISC_FEATURE
<222>  (21)..(21)
<223>  Xaa21 is Nle(epsilon-N3)

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Lys24 is conjugated to  PEG2PEG2-gamma-Glu-C16N3

<400>  59

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Lys Trp Leu Leu Asp Thr 
            20                  25                  


<210>  60
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide


<220>
<221>  PEPTIDE
<222>  (1)..(29)
<223>  C-terminal amide

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa2 is D-Ser

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  Lys20 is conjugated to  PEG2PEG2-gamma-Glu-C16N3

<400>  60

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Leu Asp Thr 
            20                  25                  


<210>  61
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide


<220>
<221>  PEPTIDE
<222>  (1)..(29)
<223>  C-terminal amide

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa2 is D-Ser

<220>
<221>  MISC_FEATURE
<222>  (21)..(21)
<223>  Lys21 is conjugated to  PEG2PEG2gamma-Glu-C16N3

<400>  61

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Gln Lys Phe Val Gln Trp Leu Leu Asp Thr 
            20                  25                  


<210>  62
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide


<220>
<221>  PEPTIDE
<222>  (1)..(31)
<223>  C-terminal amide

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa2 is aib

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa16 is aib

<220>
<221>  MISC_FEATURE
<222>  (31)..(31)
<223>  Lys31 is conjugated to  PEG2PEG2-gamma-Glu-C16N3

<400>  62

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Gln Trp Leu Leu Asp Thr Lys Lys 
            20                  25                  30      


<210>  63
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide


<220>
<221>  PEPTIDE
<222>  (1)..(29)
<223>  C-terminal amide

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa2 is D-Ser

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Lys10 is conjugated to  PEG2PEG2-gamma-Glu-C18OH

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Xaa24 is Nle(epsilon-N3)

<400>  63

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Xaa Trp Leu Leu Asp Thr 
            20                  25                  


<210>  64
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide


<220>
<221>  PEPTIDE
<222>  (1)..(29)
<223>  C-terminal amide

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa2 is aib

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  Lys20 is cojugated to  PEG2PEG2-gamma-Glu-C18-OH

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Xaa24 is Nle(epsilon-N3)

<220>
<221>  MISC_FEATURE
<222>  (27)..(27)
<223>  Xaa27 is methione sulfone

<400>  64

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ala 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Xaa Trp Leu Xaa Asp Thr 
            20                  25                  


<210>  65
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide


<220>
<221>  PEPTIDE
<222>  (1)..(29)
<223>  C-terminal amide

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa2 is aib

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  Lys20 is conjugated to  PEG2PEG2-gamma-Glu-C20-OH

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Xaa24 is Nle(epsilon-N3)

<220>
<221>  MISC_FEATURE
<222>  (27)..(27)
<223>  Xaa27 is methione sulfone

<400>  65

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ala 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Xaa Trp Leu Xaa Asp Thr 
            20                  25                  


<210>  66
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide


<220>
<221>  PEPTIDE
<222>  (1)..(29)
<223>  C-terminal amide

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa2 is D-Ser

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa9 is alpha-MD

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Lys10 conjugated to  gamma-Glu-gamma-Glu-C16

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Xaa24 is Nle(epsilon-N3)

<220>
<221>  MISC_FEATURE
<222>  (27)..(27)
<223>  Xaa27 is methione sulfone

<400>  66

His Xaa Gln Gly Thr Phe Thr Ser Xaa Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Xaa Trp Leu Xaa Asp Thr 
            20                  25                  


<210>  67
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide


<220>
<221>  PEPTIDE
<222>  (1)..(29)
<223>  C-terminal amide

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa2 is D-Ser

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Lys10 conjugated to  gamma-Glu-gamma-Glu-C16

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa14 is alpha-ML

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Xaa24 is Nle(epsilon-N3)

<220>
<221>  MISC_FEATURE
<222>  (27)..(27)
<223>  Xaa27 is methione sulfone

<400>  67

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Xaa Asp Glu 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Xaa Trp Leu Xaa Asp Thr 
            20                  25                  


<210>  68
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide


<220>
<221>  PEPTIDE
<222>  (1)..(29)
<223>  C-terminal amide

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa2 is D-Ser

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Lys10 conjugated to  gamma-Glu-gamma-Glu-C16

<220>
<221>  MISC_FEATURE
<222>  (21)..(21)
<223>  Xaa21 is alpha-MD

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Xaa24 is Nle(epsilon-N3)

<220>
<221>  MISC_FEATURE
<222>  (27)..(27)
<223>  Xaa27 is methione sulfone

<400>  68

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Gln Xaa Phe Val Xaa Trp Leu Xaa Asp Thr 
            20                  25                  


<210>  69
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide


<220>
<221>  PEPTIDE
<222>  (1)..(29)
<223>  C-terminal amide

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa2 is D-Ser

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa9 is alpha-MF

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Lys10 conjugated to  gamma-Glu-gamma-Glu-C16

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Xaa24 is Nle(epsilon-N3)

<220>
<221>  MISC_FEATURE
<222>  (27)..(27)
<223>  Xaa27 is methione sulfone

<400>  69

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Gln Asp Xaa Val Xaa Trp Leu Xaa Asp Thr 
            20                  25                  


<210>  70
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide


<220>
<221>  PEPTIDE
<222>  (1)..(29)
<223>  C-terminal amide

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa2 is D-Ser

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Lys10 conjugated to  gamma-Glu-gamma-Glu-C16

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Xaa24 is Nle(epsilon-N3)

<220>
<221>  MISC_FEATURE
<222>  (25)..(25)
<223>  Xaa25 is alpha-MW

<220>
<221>  MISC_FEATURE
<222>  (27)..(27)
<223>  Xaa27 is methione sulfone

<400>  70

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Xaa Xaa Leu Xaa Asp Thr 
            20                  25                  


<210>  71
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide


<220>
<221>  PEPTIDE
<222>  (1)..(29)
<223>  C-terminal amide

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa2 is D-Ser

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Lys10 conjugated to  gamma-Glu-gamma-Glu-C16

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Xaa24 is Nle(epsilon-N3)

<220>
<221>  MISC_FEATURE
<222>  (26)..(26)
<223>  Xaa26 is alpha-ML

<220>
<221>  MISC_FEATURE
<222>  (27)..(27)
<223>  Xaa27 is methione sulfone

<400>  71

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Xaa Trp Xaa Xaa Asp Thr 
            20                  25                  


<210>  72
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide


<220>
<221>  PEPTIDE
<222>  (1)..(29)
<223>  C-terminal amide

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa2 is D-Ser

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Lys10 conjugated to  gamma-Glu-gamma-Glu-C16

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Xaa24 is Nle(epsilon-N3)

<220>
<221>  MISC_FEATURE
<222>  (27)..(27)
<223>  Xaa27 is methione sulfone

<220>
<221>  MISC_FEATURE
<222>  (28)..(28)
<223>  Xaa28 is alpha-MD

<400>  72

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Xaa Trp Leu Xaa Xaa Thr 
            20                  25                  


<210>  73
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide


<220>
<221>  PEPTIDE
<222>  (1)..(31)
<223>  C-terminal amide

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa2 is alpha-MS

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Lys10 conjugated to  gamma-Glu-gamma-Glu-C16

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa16 is aib

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Xaa24 is Nle(epsilon-N3)

<220>
<221>  MISC_FEATURE
<222>  (31)..(31)
<223>  Xaa31 is gamma-Glu

<400>  73

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Xaa Trp Leu Leu Ala Thr Lys Xaa 
            20                  25                  30      


<210>  74
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide


<220>
<221>  PEPTIDE
<222>  (1)..(31)
<223>  C-terminal amide

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa2 is alpha-Ms

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Lys10 conjugated to  gamma-Glu-gamma-Glu-C16

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa16 is aib

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Xaa24 is Nle(epsilon-N3)

<220>
<221>  MISC_FEATURE
<222>  (31)..(31)
<223>  Xaa31 is gamma-Glu

<400>  74

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Xaa Trp Leu Leu Ala Thr Lys Xaa 
            20                  25                  30      


<210>  75
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide


<220>
<221>  PEPTIDE
<222>  (1)..(29)
<223>  C-terminal amide

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa2 is alpha-MS

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Lys10 conjugated to  gamma-Glu-gamma-Glu-C16

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Xaa24 is Nle(epsilon-N3)

<400>  75

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Ala 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Xaa Trp Leu Leu Asp Thr 
            20                  25                  


<210>  76
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide


<220>
<221>  PEPTIDE
<222>  (1)..(29)
<223>  C-terminal amide

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa2 is alpha-Ms

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Lys10 conjugated to  gamma-Glu-gamma-Glu-C16

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Xaa24 is Nle(epsilon-N3)

<400>  76

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Ala 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Xaa Trp Leu Leu Asp Thr 
            20                  25                  


<210>  77
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide


<220>
<221>  PEPTIDE
<222>  (1)..(29)
<223>  C-terminal amide

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa2 is alpha-Ms

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Lys10 conjugated to  gamma-Glu-gamma-Glu-C16

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa16 is aib

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Xaa24 is Nle(epsilon-N3)

<220>
<221>  MISC_FEATURE
<222>  (27)..(27)
<223>  Xaa27 is methione sulfone

<400>  77

His Xaa Val Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Xaa Trp Leu Xaa Asp Thr 
            20                  25                  


<210>  78
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide


<220>
<221>  PEPTIDE
<222>  (1)..(31)
<223>  C-terminal amide

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa2 is aib

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Lys10 conjugated to  gamma-Glu-gamma-Glu-C16

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Xaa24 is Nle(epsilon-N3)

<220>
<221>  MISC_FEATURE
<222>  (27)..(27)
<223>  Xaa27 is methione sulfone

<400>  78

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Xaa Trp Leu Xaa Asp Gly Arg Gly 
            20                  25                  30      


<210>  79
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide


<220>
<221>  PEPTIDE
<222>  (1)..(31)
<223>  C-terminal amide

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa2 is aib

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Lys10 conjugated to  gamma-Glu-gamma-Glu-C16

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Xaa24 is Nle(epsilon-N3)

<220>
<221>  MISC_FEATURE
<222>  (27)..(27)
<223>  Xaa27 is methione sulfone

<220>
<221>  MISC_FEATURE
<222>  (28)..(28)
<223>  Xaa28 is alpha-MD

<400>  79

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Xaa Trp Leu Xaa Xaa Gly Arg Gly 
            20                  25                  30      


<210>  80
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide


<220>
<221>  PEPTIDE
<222>  (1)..(31)
<223>  C-terminal amide

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa2 is aib

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Lys10 conjugated to  gamma-Glu-gamma-Glu-C16

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa16 is aib

<220>
<221>  MISC_FEATURE
<222>  (30)..(30)
<223>  Xaa30 is Nle(epsilon-N3)

<220>
<221>  MISC_FEATURE
<222>  (31)..(31)
<223>  Xaa31 is  gamma-Glu

<400>  80

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Gln Trp Leu Leu Asp Thr Xaa Xaa 
            20                  25                  30      


<210>  81
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide


<220>
<221>  PEPTIDE
<222>  (1)..(31)
<223>  C-terminal amide

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa2 is aib

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Lys10 conjugated to  gamma-Glu-gamma-Glu-C16

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa16 is aib

<220>
<221>  MISC_FEATURE
<222>  (27)..(27)
<223>  Xaa27 is methione sulfone

<220>
<221>  MISC_FEATURE
<222>  (30)..(30)
<223>  Xaa30 is Nle(epsilon-N3)

<220>
<221>  MISC_FEATURE
<222>  (31)..(31)
<223>  Xaa31 is  gamma-Glu

<400>  81

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Gln Trp Leu Xaa Asp Thr Xaa Xaa 
            20                  25                  30      


<210>  82
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide


<220>
<221>  PEPTIDE
<222>  (1)..(31)
<223>  C-terminal amide

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa2 is aib

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Lys10 conjugated to  gamma-Glu-gamma-Glu-C16

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa16 is aib

<220>
<221>  MISC_FEATURE
<222>  (27)..(27)
<223>  Xaa27 is methione sulfone

<220>
<221>  MISC_FEATURE
<222>  (28)..(28)
<223>  Xaa28 is alpha-MD

<220>
<221>  MISC_FEATURE
<222>  (30)..(30)
<223>  Xaa30 is Nle(epsilon-N3)

<220>
<221>  MISC_FEATURE
<222>  (31)..(31)
<223>  Xaa31 is  gamma-Glu

<400>  82

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Gln Trp Leu Xaa Xaa Thr Xaa Xaa 
            20                  25                  30      


<210>  83
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide


<220>
<221>  PEPTIDE
<222>  (1)..(28)

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa2 is aib

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Lys10 conjugated to  gamma-Glu-gamma-Glu-C16

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa16 is aib

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Xaa24 is Nle(epsilon-N3)

<220>
<221>  MISC_FEATURE
<222>  (27)..(27)
<223>  Xaa27 is methione sulfone

<220>
<221>  MISC_FEATURE
<222>  (28)..(28)
<223>  Xaa28 is alpha-MD

<400>  83

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Xaa Trp Leu Xaa Xaa Thr 
            20                  25                  


<210>  84
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide


<220>
<221>  PEPTIDE
<222>  (1)..(29)
<223>  C-terminal amide

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa2 is D-Ser

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Lys10 conjugated to  gamma-Glu-gamma-Glu-C16

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Xaa24 is Nle(epsilon-N3)

<400>  84

His Xaa Glu Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Xaa Trp Leu Leu Asp Thr 
            20                  25                  


<210>  85
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide


<220>
<221>  PEPTIDE
<222>  (1)..(29)
<223>  C-terminal amide

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa2 is D-Ser

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Lys10 conjugated to  gamma-Glu-gamma-Glu-C16

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Lys24 is conjugated to  PEG2PEG2-C5N3

<220>
<221>  MISC_FEATURE
<222>  (27)..(27)
<223>  Xaa27 is methione sulfone

<400>  85

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Lys Trp Leu Xaa Asp Thr 
            20                  25                  


<210>  86
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide


<220>
<221>  PEPTIDE
<222>  (1)..(29)
<223>  C-terminal amide

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa2 is D-Ser

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Lys10 conjugated to  gamma-Glu-gamma-Glu-C16

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Lys24 is conjugated to  PEG2PEG2-C5N3

<220>
<221>  MISC_FEATURE
<222>  (27)..(27)
<223>  Xaa27 is methione sulfone

<220>
<221>  MISC_FEATURE
<222>  (28)..(28)
<223>  Xaa28 is alpha-MD

<400>  86

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Lys Trp Leu Xaa Xaa Thr 
            20                  25                  


<210>  87
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide


<220>
<221>  PEPTIDE
<222>  (1)..(29)
<223>  C-terminal amide

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa2 is D-Ser

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Lys10 conjugated to  gamma-Glu-gamma-Glu-C16

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Lys24 is conjugated to  PEG2-C10N3

<400>  87

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Lys Trp Leu Leu Asp Thr 
            20                  25                  


<210>  88
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide


<220>
<221>  PEPTIDE
<222>  (1)..(29)
<223>  C-terminal amide

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa2 is D-Ser

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Lys10 conjugated to  gamma-Glu-gamma-Glu-C16

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Lys24 is conjugated to  PEG2-C16N3

<400>  88

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Lys Trp Leu Leu Asp Thr 
            20                  25                  


<210>  89
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide


<220>
<221>  PEPTIDE
<222>  (1)..(29)
<223>  C-terminal amide

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa2 is aib

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Lys10 conjugated to  gamma-Glu-gamma-Glu-C16

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa16 is aib

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Lys24 is conjugated to PEG2PEG2- C5N3

<220>
<221>  MISC_FEATURE
<222>  (27)..(27)
<223>  Xaa27 is methione sulfone

<400>  89

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Lys Trp Leu Xaa Asp Thr 
            20                  25                  


<210>  90
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide


<220>
<221>  PEPTIDE
<222>  (1)..(29)
<223>  C-terminal amide

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa2 is aib

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Lys10 conjugated to  gamma-Glu-gamma-Glu-C16

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa16 is aib

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Lys24 is conjugated to PEG2PEG2- C5N3

<220>
<221>  MISC_FEATURE
<222>  (27)..(27)
<223>  Xaa27 is methione sulfone

<400>  90

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Lys Trp Leu Xaa Asp Thr 
            20                  25                  


<210>  91
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide


<220>
<221>  PEPTIDE
<222>  (1)..(29)
<223>  C-terminal amide

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa2 is D-Ser

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Lys10 conjugated to  gamma-Glu-gamma-Glu-C16

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  Lys20 is conjugated to PEG2PEG2-gamma-Glu-C10N3

<400>  91

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Leu Asp Thr 
            20                  25                  


<210>  92
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide


<220>
<221>  PEPTIDE
<222>  (1)..(29)
<223>  C-terminal amide

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa2 is D-Ser

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Lys10 conjugated to  gamma-Glu-gamma-Glu-C16

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  Lys20 is conjugated to PEG2PEG2-gamma-Glu-C16N3

<400>  92

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Leu Asp Thr 
            20                  25                  


<210>  93
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide


<220>
<221>  PEPTIDE
<222>  (1)..(31)
<223>  C-terminal amide

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa2 is D-Ser

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Lys10 conjugated to  gamma-Glu-gamma-Glu-C16

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa16 is aib

<220>
<221>  MISC_FEATURE
<222>  (30)..(30)
<223>  Xaa30 is Nle(epsilon-N3)

<220>
<221>  MISC_FEATURE
<222>  (31)..(31)
<223>  Xaa31 is  gamma-Glu

<400>  93

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Gln Trp Leu Leu Asp Thr Lys Xaa 
            20                  25                  30      


<210>  94
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide


<220>
<221>  PEPTIDE
<222>  (1)..(31)
<223>  C-terminal amide

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa2 is D-Ser

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Lys10 conjugated to  gamma-Glu-gamma-Glu-C16

<220>
<221>  MISC_FEATURE
<222>  (30)..(30)
<223>  Xaa30 is Nle(epsilon-N3)

<220>
<221>  MISC_FEATURE
<222>  (31)..(31)
<223>  Xaa31 is  gamma-Glu

<400>  94

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Gln Trp Leu Leu Asp Thr Lys Xaa 
            20                  25                  30      


<210>  95
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide


<220>
<221>  PEPTIDE
<222>  (1)..(31)
<223>  C-terminal amide

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa2 is D-Ser

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Lys10 conjugated to  gamma-Glu-gamma-Glu-C16

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa16 is aib

<220>
<221>  MISC_FEATURE
<222>  (31)..(31)
<223>  Xaa31 is conjugated to  PEG2PEG2-C5N3

<400>  95

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Gln Trp Leu Leu Asp Thr Lys Lys 
            20                  25                  30      


<210>  96
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide


<220>
<221>  PEPTIDE
<222>  (1)..(31)
<223>  C-terminal amide

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa2 is D-Ser

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Lys10 conjugated to  gamma-Glu-gamma-Glu-C16

<220>
<221>  MISC_FEATURE
<222>  (31)..(31)
<223>  Xaa31 is conjugated to  PEG2PEG2-C5N3

<400>  96

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Gln Trp Leu Leu Asp Thr Lys Lys 
            20                  25                  30      


<210>  97
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide


<220>
<221>  PEPTIDE
<222>  (1)..(31)
<223>  C-terminal amide

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa2 is D-Ser

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Lys10 conjugated to  gamma-Glu-gamma-Glu-C16

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa16 is aib

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Xaa24 is Nle(epsilon-N3)

<220>
<221>  MISC_FEATURE
<222>  (31)..(31)
<223>  Xaa31 is gamma-Glu

<400>  97

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Xaa Trp Leu Leu Asp Thr Lys Xaa 
            20                  25                  30      


<210>  98
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide


<220>
<221>  PEPTIDE
<222>  (1)..(31)
<223>  C-terminal amide

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa2 is aib

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Lys10 conjugated to  gamma-Glu-gamma-Glu-C16

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa16 is aib

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Lys24 is conjugated to PEG2-C5N3

<220>
<221>  MISC_FEATURE
<222>  (31)..(31)
<223>  Xaa31 is gamma-Glu

<400>  98

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Lys Trp Leu Leu Asp Thr Lys Xaa 
            20                  25                  30      


<210>  99
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide


<220>
<221>  PEPTIDE
<222>  (1)..(31)
<223>  C-terminal amide

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa2 is aib

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Lys10 conjugated to  gamma-Glu-gamma-Glu-C16

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa16 is aib

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Lys24 is conjugated to PEG2PEG2-C5N3

<220>
<221>  MISC_FEATURE
<222>  (31)..(31)
<223>  Xaa31 is gamma-Glu

<400>  99

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Lys Trp Leu Leu Asp Thr Lys Xaa 
            20                  25                  30      


<210>  100
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide


<220>
<221>  PEPTIDE
<222>  (1)..(29)
<223>  C-terminal amide

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa2 is D-Ser

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Lys10 conjugated to  gamma-Glu-gamma-Glu-C16

<220>
<221>  MISC_FEATURE
<222>  (21)..(21)
<223>  Lys21 is conjugated to  PEG2PEG2-gamma-GluC16N3

<400>  100

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Gln Lys Phe Val Gln Trp Leu Leu Asp Thr 
            20                  25                  


<210>  101
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide


<220>
<221>  PEPTIDE
<222>  (1)..(29)
<223>  C-terminal amide

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa2 is D-Ser

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Lys10 conjugated to  gamma-Glu-gamma-Glu-C16

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Lys24 is conjugated to PEG2PEG2-gamma-glu-C16N3

<400>  101

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Lys Trp Leu Leu Asp Thr 
            20                  25                  


<210>  102
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide


<220>
<221>  PEPTIDE
<222>  (1)..(31)
<223>  C-terminal amide

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa2 is aib

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa16 is aib

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Xaa24 is Nle(epsilon-N3)

<400>  102

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Xaa Trp Leu Met Asn Thr Lys Gln 
            20                  25                  30      


<210>  103
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide


<220>
<221>  PEPTIDE
<222>  (1)..(29)
<223>  C-terminal amide

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa2 is D-Ser

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Xaa24 is Nle(epsilon-N3)

<400>  103

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Xaa Trp Leu Leu Asp Thr 
            20                  25                  


<210>  104
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide


<220>
<221>  PEPTIDE
<222>  (1)..(31)
<223>  C-terminal amide

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa2 is aib

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa16 is aib

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  Xaa20 is Nle(epsilon-N3)

<400>  104

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Ala Ala Xaa Asp Phe Val Gln Trp Leu Met Asn Thr Lys Gln 
            20                  25                  30      


<210>  105
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide


<220>
<221>  PEPTIDE
<222>  (1)..(29)
<223>  C-terminal amide

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa2 is D-Ser

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  Xaa20 is Nle(epsilon-N3)

<400>  105

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Xaa Asp Phe Val Gln Trp Leu Leu Asp Thr 
            20                  25                  


<210>  106
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide


<220>
<221>  PEPTIDE
<222>  (1)..(32)
<223>  C-terminal amide

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa2 is aib

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa16 is aib

<220>
<221>  MISC_FEATURE
<222>  (32)..(32)
<223>  Xaa32 is Nle(epsilon-N3)

<400>  106

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr Lys Gln Xaa 
            20                  25                  30          


<210>  107
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide


<220>
<221>  PEPTIDE
<222>  (1)..(30)
<223>  C-terminal amide

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa2 is D-Ser

<220>
<221>  MISC_FEATURE
<222>  (30)..(30)
<223>  Xaa30 is Nle(epsilon-N3)

<400>  107

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Gln Trp Leu Leu Asp Thr Xaa 
            20                  25                  30  


<210>  108
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide


<220>
<221>  PEPTIDE
<222>  (1)..(29)
<223>  C-terminal amide

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa2 is D-Ser

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Lys10 conjugated to  gamma-Glu-gamma-Glu-C16

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Lys10 conjugated to  gamma-Glu-gamma-Glu-C16

<400>  108

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Xaa Trp Leu Leu Asp Thr 
            20                  25                  


<210>  109
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide


<220>
<221>  PEPTIDE
<222>  (1)..(29)
<223>  C-terminal amide

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa2 is D-Ser

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Lys10 conjugated to  gamma-Glu-gamma-Glu-C16

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Xaa24 is Nle(epsilon-N3)

<400>  109

His Xaa Glu Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Xaa Trp Leu Leu Asp Thr 
            20                  25                  


<210>  110
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide


<220>
<221>  PEPTIDE
<222>  (1)..(40)
<223>  C terminal amide

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  Xaa40 is Nle(epsilonN3)

<400>  110

His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Met Glu Glu 
1               5                   10                  15      


Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Asn Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Xaa 
        35                  40  


<210>  111
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa2 is aib

<220>
<221>  MISC_FEATURE
<222>  (32)..(32)
<223>  Xaa32 is Nle(epsilonN3)

<400>  111

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Arg Gly Arg Gly Xaa 
            20                  25                  30          


<210>  112
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide


<220>
<221>  MISC_FEATURE
<222>  (32)..(32)
<223>  Xaa32 is Nle(epsilonN3)

<400>  112

His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Arg Gly Arg Gly Xaa 
            20                  25                  30          


<210>  113
<211>  45
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide


<220>
<221>  PEPTIDE
<222>  (1)..(45)
<223>  C terminal amide

<220>
<221>  MISC_FEATURE
<222>  (45)..(45)
<223>  Xaa45 is Nle(epsilonN3)

<400>  113

His Gly Glu Gly Thr Phe Thr Ser Lys Leu Ser Lys Gln Met Glu Glu 
1               5                   10                  15      


Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Asn Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Ser Lys Lys Lys Lys Lys Lys Xaa 
        35                  40                  45  


<210>  114
<211>  45
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide


<220>
<221>  PEPTIDE
<222>  (1)..(45)
<223>  C terminal amide

<220>
<221>  MISC_FEATURE
<222>  (45)..(45)
<223>  Xaa45 is Nle(epsilonN3)

<400>  114

His Gly Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Gly Gly Gly 
            20                  25                  30          


Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Ala Xaa 
        35                  40                  45  


<210>  115
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide


<220>
<221>  MISC_FEATURE
<222>  (30)..(30)
<223>  Xaa30 is Nle(epsilonN3)

<400>  115

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr Xaa 
            20                  25                  30  


<210>  116
<211>  43
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide


<220>
<221>  MISC_FEATURE
<222>  (43)..(43)
<223>  Xaa43 is Nle(epsilonN3)

<400>  116

Tyr Ala Glu Gly Thr Phe Ile Ser Asp Tyr Ser Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln Xaa 
        35                  40              


<210>  117
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide


<220>
<221>  PEPTIDE
<222>  (1)..(40)
<223>  C-terminal amide

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa2 is aib

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  Xaa20 is aib

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  Xaa44 is Nle(epsilonN3)

<400>  117

Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Lys 
1               5                   10                  15      


Gln Ala Ala Xaa Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Xaa 
        35                  40  


<210>  118
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide


<220>
<221>  PEPTIDE
<222>  (1)..(40)
<223>  c TERMINAL AMIDE

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is aib

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  Xaa40 is Nle(epsilonN3)

<400>  118

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Gln Trp Leu Leu Asp Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Xaa 
        35                  40  


<210>  119
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide


<220>
<221>  MISC_FEATURE
<222>  (38)..(38)
<223>  Xaa38 is Nle(epsilonN3)

<400>  119

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr Lys Arg Asn 
            20                  25                  30          


Lys Asn Asn Ile Ala Xaa 
        35              


<210>  120
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide


<220>
<221>  MISC_FEATURE
<222>  (27)..(27)
<223>  Xaa27 is Nle(epsilonN3)

<400>  120

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Xaa Asn Thr Lys Arg Asn 
            20                  25                  30          


Lys Asn Asn Ile Ala 
        35          


<210>  121
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide


<220>
<221>  PEPTIDE
<222>  (1)..(29)
<223>  C terminal amide

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is D-Ser

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Lys10 conjugated to gamma-Glu-gamma-Glu-C16

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Xaa24 is Nle(epsilonN3)

<400>  121

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Xaa Trp Leu Leu Asp Thr 
            20                  25                  


<210>  122
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide


<220>
<221>  PEPTIDE
<222>  (1)..(29)
<223>  C terminal amide

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is D-Ser

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Xaa24 is Nle(epsilonN3)

<400>  122

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Xaa Trp Leu Leu Asp Thr 
            20                  25                  


<210>  123
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide


<220>
<221>  PEPTIDE
<222>  (1)..(32)
<223>  C terminal amide

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa2 is aib

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Lys10 conjugated to gamma-Glu-gamma-Glu-C16

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa16 is aib

<400>  123

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr Lys Gln Xaa 
            20                  25                  30          


<210>  124
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide


<220>
<221>  PEPTIDE
<222>  (1)..(29)
<223>  C terminal amide

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa2 is D-Ser

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Lys24 conjugated to PEG2PEG2-gamma-Glu-C16N3

<400>  124

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Lys Trp Leu Leu Asp Thr 
            20                  25                  


<210>  125
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide


<220>
<221>  PEPTIDE
<222>  (1)..(31)
<223>  C terminal amide

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa2 is aib

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Lys10 conjugated to gamma-Glu-gamma-Glu-C16

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa16 is aib

<220>
<221>  MISC_FEATURE
<222>  (31)..(31)
<223>  Lys31 conjugated to PEG2PEG2-C5N3

<220>
<221>  misc_feature
<222>  (32)..(32)
<223>  Xaa can be any naturally occurring amino acid

<400>  125

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Gln Trp Leu Leu Asp Thr Lys Lys Xaa 
            20                  25                  30          


<210>  126
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  126

Gly Ile Val Glu Gln Cys Cys Thr Ser Ile Cys Ser Leu Tyr Gln Leu 
1               5                   10                  15      


Glu Asn Tyr Cys Asn 
            20      


<210>  127
<211>  30
<212>  PRT
<213>  Homo sapiens

<400>  127

Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      


Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr Thr Pro Lys Thr 
            20                  25                  30  


<210>  128
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Lispro B chain

<400>  128

Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      


Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr Thr Lys Pro Thr 
            20                  25                  30  


<210>  129
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Aspart B chain

<400>  129

Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      


Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr Thr Asp Lys Thr 
            20                  25                  30  


<210>  130
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Glulisine B chain

<400>  130

Phe Val Lys Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      


Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr Thr Pro Glu Thr 
            20                  25                  30  


<210>  131
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Glargine A chain

<400>  131

Gly Ile Val Glu Gln Cys Cys Thr Ser Ile Cys Ser Leu Tyr Gln Leu 
1               5                   10                  15      


Glu Asn Tyr Cys Gly 
            20      


<210>  132
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Glargine B chain

<400>  132

Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      


Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr Thr Pro Lys Thr Arg Arg 
            20                  25                  30          


<210>  133
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide


<220>
<221>  MISC_FEATURE
<222>  (8)..(8)

<220>
<221>  MISC_FEATURE
<222>  (21)..(21)
<223>  Xaa is asparagine or glycine

<400>  133

Gly Ile Val Glu Gln Cys Cys Xaa Ser Ile Cys Ser Leu Tyr Gln Leu 
1               5                   10                  15      


Glu Asn Tyr Cys Xaa 
            20      


<210>  134
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is selected from the group consisting of histidine and 
       threonine

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa is selected from the group consisting of alanine, glycine and
       serine;

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa is selected from the group consisting of histidine, aspartic 
       acid, glutamic acid, homocysteic acid and cysteic acid

<400>  134

Xaa Leu Cys Gly Xaa Xaa Leu Val Glu Ala Leu Tyr Leu Val Cys Gly 
1               5                   10                  15      


Glu Arg Gly Phe Phe 
            20      


<210>  135
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is selected from the group consisting of phenylalanine and 
       desamino-phenylalanine.

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa is selected from the group consisting of histidine and 
       threonine;

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa is selected from the group consisting of alanine, glycine and
       serine;

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa is selected from the group consisting of histidine, aspartic 
       acid, glutamic acid, homocysteic acid and cysteic acid

<220>
<221>  misc_feature
<222>  (28)..(28)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  Xaa is threonine, alanine, or a threonine-arginine-arginine 
       tripeptide

<400>  135

Xaa Val Asn Gln Xaa Leu Cys Gly Xaa Xaa Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      


Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr Thr Xaa Xaa 
            20                  25                  


<210>  136
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa1 is glycine (G) or lysine (K)

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa3 is valine (V), glycine (G), or lysine (K)

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa5 is valine (V), glycine (G), or lysine (K)

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa8 is threonine (T) or histidine (H)

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa9 is serine (S) or lysine (K)

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa10 is isoleucine (I) or lysine

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  Xaa13 is leucine (L) or lysine (K)

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa14 is tyrosine (Y) or lysine (K)

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  Xaa15 is glutamine (Q) or lysine (K)

<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  Xaa18 is asparagine (N) or lysine (K)

<220>
<221>  MISC_FEATURE
<222>  (21)..(21)
<223>  Xaa21 is asparagine (N) or glycine (G)

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  Xaa22 is arginine (R), lysine (K) or absent

<400>  136

Xaa Ile Xaa Glu Xaa Cys Cys Xaa Xaa Xaa Cys Ser Xaa Xaa Xaa Leu 
1               5                   10                  15      


Glu Xaa Tyr Cys Xaa Xaa 
            20          


<210>  137
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa1 is phenylalanine (F) or lysine (K)

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa3 is asparagine (N) or lysine (K)

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa4 is glutamine (Q) or lysine (K)

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa16 is tyrosine (Y) or lysine (K)

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  Xaa17 is leucine (L) or lysine (K)

<220>
<221>  MISC_FEATURE
<222>  (25)..(25)
<223>  Xaa25 is phenylalanine (F) or lysine (K)

<220>
<221>  MISC_FEATURE
<222>  (28)..(28)
<223>  Xaa28 is proline (P) or lysine (K)

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  Xaa29 is lysine (K) or proline (P)

<220>
<221>  MISC_FEATURE
<222>  (30)..(30)
<223>  Xaa30 is threonine (T) or absent

<220>
<221>  MISC_FEATURE
<222>  (31)..(31)
<223>  Xaa31 is arginine (R) if Xaa30 is threonine (T), or absent

<220>
<221>  MISC_FEATURE
<222>  (32)..(32)
<223>  Xaa32 is proline (P) if Xaa31 is arginine (R), or absent

<220>
<221>  MISC_FEATURE
<222>  (33)..(33)
<223>  Xaa33 is arginine (R) if Xaa32 is proline (P), or absent

<220>
<221>  MISC_FEATURE
<222>  (34)..(34)
<223>  Xaa34 is proline (P) if Xaa33 is arginine (R), or absent

<220>
<221>  MISC_FEATURE
<222>  (35)..(35)
<223>  Xaa35 is arginine (R) if Xaa34 is proline (P), or absent

<400>  137

Xaa Val Xaa Xaa His Leu Cys Gly Ser His Leu Val Glu Ala Leu Xaa 
1               5                   10                  15      


Xaa Val Cys Gly Glu Arg Gly Phe Xaa Tyr Thr Xaa Xaa Xaa Xaa Xaa 
            20                  25                  30          


Xaa Xaa Xaa 
        35  


<210>  138
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa1 is phenylalanine (F) or lysine (K)

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa3 is asparagine (N) or lysine (K)

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa4 is glutamine (Q) or lysine (K)

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa16 is tyrosine (Y) or lysine (K)

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  Xaa17 is leucine (L) or lysine (K)

<220>
<221>  MISC_FEATURE
<222>  (25)..(25)
<223>  Xaa25 is phenylalanine (F) or lysine (K)

<220>
<221>  MISC_FEATURE
<222>  (28)..(28)
<223>  Xaa28 is proline (P) or lysine (K)

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  Xaa29 is lysine (K) or proline (P)

<400>  138

Xaa Val Xaa Xaa His Leu Cys Gly Ser His Leu Val Glu Ala Leu Xaa 
1               5                   10                  15      


Xaa Val Cys Gly Glu Arg Gly Phe Xaa Tyr Thr Xaa Xaa 
            20                  25                  


<210>  139
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa1 is phenylalanine (F) or lysine (K)

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa3 is asparagine (N) or lysine (K)

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa4 is glutamine (Q) or lysine (K)

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa16 is tyrosine (Y) or lysine (K)

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  Xaa17 is leucine (L) or lysine (K)

<220>
<221>  MISC_FEATURE
<222>  (25)..(25)
<223>  Xaa25 is phenylalanine (F) or lysine (K)

<220>
<221>  MISC_FEATURE
<222>  (28)..(28)
<223>  Xaa28 is proline (P) or lysine (K)

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  Xaa29 is lysine (K) or proline (P)

<400>  139

Xaa Val Xaa Xaa His Leu Cys Gly Ser His Leu Val Glu Ala Leu Xaa 
1               5                   10                  15      


Xaa Val Cys Gly Glu Arg Gly Phe Xaa Tyr Thr Xaa Xaa Thr Arg Pro 
            20                  25                  30          


Arg Pro Arg 
        35  


<210>  140
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa1 is phenylalanine (F) or lysine (K)

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa3 is asparagine (N) or lysine (K)

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa4 is glutamine (Q) or lysine (K)

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa16 is tyrosine (Y) or lysine (K)

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  Xaa17 is leucine (L) or lysine (K)

<220>
<221>  MISC_FEATURE
<222>  (25)..(25)
<223>  Xaa25 is phenylalanine (F) or lysine (K)

<220>
<221>  MISC_FEATURE
<222>  (28)..(28)
<223>  Xaa28 is proline (P) or lysine (K)

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  Xaa29 is lysine (K) or proline (P)

<400>  140

Xaa Val Xaa Xaa His Leu Cys Gly Ser His Leu Val Glu Ala Leu Xaa 
1               5                   10                  15      


Xaa Val Cys Gly Glu Arg Gly Phe Xaa Tyr Thr Xaa Xaa Thr Arg Pro 
            20                  25                  30          


Arg 
    


<210>  141
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Petide


<220>
<221>  PEPTIDE
<222>  (1)..(29)
<223>  C terminal amide

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa2 is D-Ser

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Lys10 conjugated to gamma-Glu-gamma-Glu-C16

<400>  141

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Gln Trp Leu Leu Asp Thr 
            20                  25                  


