                         SEQUENCE LISTING

<110>  Fundaci Hospital Universitari Vall d'Hebron-Institut de 
       Recerca
 
<120>  Dipeptidyl peptidase-4 inhibitors for use in the topical eye 
       treatment of retinal neurodegenerative diseases, in particular in
        early stages of diabetic retinopathy and other retinal diseases 
       in which neurodegeneration plays an essential role

<130>  P3572PC00

<150>  EP16382190.3
<151>  2016-04-29

<160>  3     

<170>  PatentIn version 3.5

<210>  1
<211>  31
<212>  PRT
<213>  Artificial

<220>
<223>  Liraglutide; analogue of glucagon like peptide-1 (7-37) 
       (GLP-1(7-37))


<220>
<221>  LIPID
<222>  (20)..(20)
<223>  Lysine residue (K, Lys) comprises the lipophilic substituent N 
       epsilon-(gamma-glutamyl(N-alfa-hexadecanoyl)) attached by an 
       amide link to the amino group of the lysine side chain

<400>  1

His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Arg Gly Arg Gly 
            20                  25                  30      


<210>  2
<211>  44
<212>  PRT
<213>  Artificial

<220>
<223>  Lixisenatide; glucagon-like peptide-1 agonist; derived from 
       exenatide


<220>
<221>  MOD_RES
<222>  (44)..(44)
<223>  X is a lysine residue in which the -COOH terminal has been 
       modified by a -NH2 group

<400>  2

His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Met Glu Glu 
1               5                   10                  15      


Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Asn Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Ser Lys Lys Lys Lys Lys Xaa 
        35                  40                  


<210>  3
<211>  39
<212>  PRT
<213>  Artificial

<220>
<223>  Exenatide; glucagon-like peptide-1 agonist; synthetic version of 
       hormone exendine-4 found in the saliva of the Gila monster


<220>
<221>  MOD_RES
<222>  (39)..(39)
<223>  X is a serine residue in which the -COOH terminal has been 
       modified by a -NH2 group

<400>  3

His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Met Glu Glu 
1               5                   10                  15      


Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Asn Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Xaa 
        35                  


