                         SEQUENCE LISTING

<110>  University Health Network
 
<120>  PEPTIDE-HLA COMPLEXES AND METHODS OF PRODUCING SAME

<130>  05014971-182PCT

<140>  PCT/CA2017/000102
<141>  2017-04-27

<150>  US62/328325
<151>  2016-04-27

<160>  122   

<170>  PatentIn version 3.5

<210>  1
<211>  906
<212>  DNA
<213>  Homo sapiens

<400>  1
atgatgcggc ccatcgtgct ggtgctgctg tttgccacat ctgccctggc cggaagccac       60

agcatgcggt actttttcac cagcgtgtcc agacccggca gaggcgagcc cagattcatt      120

gccgtgggct acgtggacga cacccagttc gtcagattcg acagcgacgc cgccagccag      180

cggatggaac ctagagcccc ttggatcgag caggaaggcc ccgagtactg ggacggcgag      240

acacggaaag tgaaggccca cagccagacc cacagagtgg atctgggcac cctgcggggc      300

tactacaatc agtctgaggc cggctcccac accgtgcaga ggatgtacgg ctgtgacgtg      360

ggcagcgact ggcggttcct gagaggctac caccagtacg cctacgacgg caaggactat      420

atcgccctga aagaggacct gcggagctgg acagccgccg atatggccgc ccagaccacc      480

aagcacaaat gggaagccgc ccacgtggcc gagcagctga gagcttatct ggaaggcacc      540

tgtgtggaat ggctgcggag atacctggaa aacggcaaag agacactgca gcgcacggac      600

gcccccaaaa cgcatatgac tcaccacgct gtctctgacc atgaagccac cctgaggtgc      660

tgggccctga gcttctaccc tgcggagatc acactgacct ggcagcggga tggggaggac      720

cagacccagg acacggagct cgtggagacc aggcctgcag gggatggaac cttccagaag      780

tgggcggctg tggtggtgcc ttctggacag gagcagagat acacctgcca tgtgcagcat      840

gagggtttgc ccaagcccct caccctgaga tgggagccgg gcagccacca ccaccatcac      900

cattga                                                                 906


<210>  2
<211>  302
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Met Arg Pro Ile Val Leu Val Leu Leu Phe Ala Thr Ser Ala Leu 
1               5                   10                  15      


Ala Gly Ser His Ser Met Arg Tyr Phe Phe Thr Ser Val Ser Arg Pro 
            20                  25                  30          


Gly Arg Gly Glu Pro Arg Phe Ile Ala Val Gly Tyr Val Asp Asp Thr 
        35                  40                  45              


Gln Phe Val Arg Phe Asp Ser Asp Ala Ala Ser Gln Arg Met Glu Pro 
    50                  55                  60                  


Arg Ala Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Gly Glu 
65                  70                  75                  80  


Thr Arg Lys Val Lys Ala His Ser Gln Thr His Arg Val Asp Leu Gly 
                85                  90                  95      


Thr Leu Arg Gly Tyr Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Val 
            100                 105                 110         


Gln Arg Met Tyr Gly Cys Asp Val Gly Ser Asp Trp Arg Phe Leu Arg 
        115                 120                 125             


Gly Tyr His Gln Tyr Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Lys 
    130                 135                 140                 


Glu Asp Leu Arg Ser Trp Thr Ala Ala Asp Met Ala Ala Gln Thr Thr 
145                 150                 155                 160 


Lys His Lys Trp Glu Ala Ala His Val Ala Glu Gln Leu Arg Ala Tyr 
                165                 170                 175     


Leu Glu Gly Thr Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly 
            180                 185                 190         


Lys Glu Thr Leu Gln Arg Thr Asp Ala Pro Lys Thr His Met Thr His 
        195                 200                 205             


His Ala Val Ser Asp His Glu Ala Thr Leu Arg Cys Trp Ala Leu Ser 
    210                 215                 220                 


Phe Tyr Pro Ala Glu Ile Thr Leu Thr Trp Gln Arg Asp Gly Glu Asp 
225                 230                 235                 240 


Gln Thr Gln Asp Thr Glu Leu Val Glu Thr Arg Pro Ala Gly Asp Gly 
                245                 250                 255     


Thr Phe Gln Lys Trp Ala Ala Val Val Val Pro Ser Gly Gln Glu Gln 
            260                 265                 270         


Arg Tyr Thr Cys His Val Gln His Glu Gly Leu Pro Lys Pro Leu Thr 
        275                 280                 285             


Leu Arg Trp Glu Pro Gly Ser His His His His His His Glx 
    290                 295                 300         


<210>  3
<211>  906
<212>  DNA
<213>  Homo sapiens

<400>  3
atgatgcggc ccatcgtgct ggtgctgctg tttgccacat ctgccctggc cggaagccac       60

agcatgcggt actttttcac cagcgtgtcc agacccggca gaggcgagcc cagattcatt      120

gccgtgggct acgtggacga cacccagttc gtcagattcg acagcgacgc cgccagccag      180

cggatggaac ctagagcccc ttggatcgag caggaaggcc ccgagtactg ggacggcgag      240

acacggaaag tgaaggccca cagccagacc cacagagtgg atctgggcac cctgcggggc      300

tactacaatc agtctgaggc cggctcccac accgtgcaga ggatgtacgg ctgtgacgtg      360

ggcagcgact ggcggttcct gagaggctac caccagtacg cctacgacgg caaggactat      420

atcgccctga aagaggacct gcggagctgg acagccgccg atatggccgc ccagaccacc      480

aagcacaaat gggaagccgc ccacgtggcc gagcagctga gagcttatct ggaaggcacc      540

tgtgtggaat ggctgcggag atacctggaa aacggcaaag agacactgca gcgcacagat      600

tccccaaagg cccatgtgac ccatcacagc agacctgaag ataaagtcac cctgaggtgc      660

tgggccctgg gcttctaccc tgctgacatc accctgacct ggcagttgaa tggggaggag      720

ctgatccagg acatggagct tgtggagacc aggcctgcag gggatggaac cttccagaag      780

tgggcatctg tggtggtgcc tcttgggaag gagcagtatt acacatgcca tgtgtaccat      840

caggggctgc ctgagcccct caccctgaga tgggagccgg gcagccacca ccaccatcac      900

cattga                                                                 906


<210>  4
<211>  302
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Met Arg Pro Ile Val Leu Val Leu Leu Phe Ala Thr Ser Ala Leu 
1               5                   10                  15      


Ala Gly Ser His Ser Met Arg Tyr Phe Phe Thr Ser Val Ser Arg Pro 
            20                  25                  30          


Gly Arg Gly Glu Pro Arg Phe Ile Ala Val Gly Tyr Val Asp Asp Thr 
        35                  40                  45              


Gln Phe Val Arg Phe Asp Ser Asp Ala Ala Ser Gln Arg Met Glu Pro 
    50                  55                  60                  


Arg Ala Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Gly Glu 
65                  70                  75                  80  


Thr Arg Lys Val Lys Ala His Ser Gln Thr His Arg Val Asp Leu Gly 
                85                  90                  95      


Thr Leu Arg Gly Tyr Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Val 
            100                 105                 110         


Gln Arg Met Tyr Gly Cys Asp Val Gly Ser Asp Trp Arg Phe Leu Arg 
        115                 120                 125             


Gly Tyr His Gln Tyr Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Lys 
    130                 135                 140                 


Glu Asp Leu Arg Ser Trp Thr Ala Ala Asp Met Ala Ala Gln Thr Thr 
145                 150                 155                 160 


Lys His Lys Trp Glu Ala Ala His Val Ala Glu Gln Leu Arg Ala Tyr 
                165                 170                 175     


Leu Glu Gly Thr Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly 
            180                 185                 190         


Lys Glu Thr Leu Gln Arg Thr Asp Ser Pro Lys Ala His Val Thr His 
        195                 200                 205             


His Ser Arg Pro Glu Asp Lys Val Thr Leu Arg Cys Trp Ala Leu Gly 
    210                 215                 220                 


Phe Tyr Pro Ala Asp Ile Thr Leu Thr Trp Gln Leu Asn Gly Glu Glu 
225                 230                 235                 240 


Leu Ile Gln Asp Met Glu Leu Val Glu Thr Arg Pro Ala Gly Asp Gly 
                245                 250                 255     


Thr Phe Gln Lys Trp Ala Ser Val Val Val Pro Leu Gly Lys Glu Gln 
            260                 265                 270         


Tyr Tyr Thr Cys His Val Tyr His Gln Gly Leu Pro Glu Pro Leu Thr 
        275                 280                 285             


Leu Arg Trp Glu Pro Gly Ser His His His His His His Glx 
    290                 295                 300         


<210>  5
<211>  906
<212>  DNA
<213>  Homo sapiens

<400>  5
atgatgcggc ccatcgtgct ggtgctgctg tttgccacat ctgccctggc cggaagccac       60

agcatgcggt actttttcac cagcgtgtcc agacccggca gaggcgagcc cagattcatt      120

gccgtgggct acgtggacga cacccagttc gtcagattcg acagcgacgc cgccagccag      180

cggatggaac ctagagcccc ttggatcgag caggaaggcc ccgagtactg ggacggcgag      240

acacggaaag tgaaggccca cagccagacc cacagagtgg atctgggcac cctgcggggc      300

tactacaatc agtctgaggc cggctcccac accgtgcaga ggatgtacgg ctgtgacgtg      360

ggcagcgact ggcggttcct gagaggctac cacgagtacg cctacgacgg caaggactat      420

atcgccctga aagaggacct gcggagctgg acagccgccg atatggccgc ccagaccacc      480

aagcacaaat gggaagccgc ccacgtggcc gagcagctga gagcttatct ggaaggcacc      540

tgtgtggaat ggctgcggag atacctggaa aacggcaaag agacactgca gcgcacagat      600

tccccaaagg cccatgtgac ccatcacagc agacctgaag ataaagtcac cctgaggtgc      660

tgggccctgg gcttctaccc tgctgacatc accctgacct ggcagttgaa tggggaggag      720

ctgatccagg acatggagct tgtggagacc aggcctgcag gggatggaac cttccagaag      780

tgggcatctg tggtggtgcc tcttgggaag gagcagtatt acacatgcca tgtgtaccat      840

caggggctgc ctgagcccct caccctgaga tgggagccgg gcagccacca ccaccatcac      900

cattga                                                                 906


<210>  6
<211>  302
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Met Arg Pro Ile Val Leu Val Leu Leu Phe Ala Thr Ser Ala Leu 
1               5                   10                  15      


Ala Gly Ser His Ser Met Arg Tyr Phe Phe Thr Ser Val Ser Arg Pro 
            20                  25                  30          


Gly Arg Gly Glu Pro Arg Phe Ile Ala Val Gly Tyr Val Asp Asp Thr 
        35                  40                  45              


Gln Phe Val Arg Phe Asp Ser Asp Ala Ala Ser Gln Arg Met Glu Pro 
    50                  55                  60                  


Arg Ala Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Gly Glu 
65                  70                  75                  80  


Thr Arg Lys Val Lys Ala His Ser Gln Thr His Arg Val Asp Leu Gly 
                85                  90                  95      


Thr Leu Arg Gly Tyr Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Val 
            100                 105                 110         


Gln Arg Met Tyr Gly Cys Asp Val Gly Ser Asp Trp Arg Phe Leu Arg 
        115                 120                 125             


Gly Tyr His Glu Tyr Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Lys 
    130                 135                 140                 


Glu Asp Leu Arg Ser Trp Thr Ala Ala Asp Met Ala Ala Gln Thr Thr 
145                 150                 155                 160 


Lys His Lys Trp Glu Ala Ala His Val Ala Glu Gln Leu Arg Ala Tyr 
                165                 170                 175     


Leu Glu Gly Thr Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly 
            180                 185                 190         


Lys Glu Thr Leu Gln Arg Thr Asp Ser Pro Lys Ala His Val Thr His 
        195                 200                 205             


His Ser Arg Pro Glu Asp Lys Val Thr Leu Arg Cys Trp Ala Leu Gly 
    210                 215                 220                 


Phe Tyr Pro Ala Asp Ile Thr Leu Thr Trp Gln Leu Asn Gly Glu Glu 
225                 230                 235                 240 


Leu Ile Gln Asp Met Glu Leu Val Glu Thr Arg Pro Ala Gly Asp Gly 
                245                 250                 255     


Thr Phe Gln Lys Trp Ala Ser Val Val Val Pro Leu Gly Lys Glu Gln 
            260                 265                 270         


Tyr Tyr Thr Cys His Val Tyr His Gln Gly Leu Pro Glu Pro Leu Thr 
        275                 280                 285             


Leu Arg Trp Glu Pro Gly Ser His His His His His His Glx 
    290                 295                 300         


<210>  7
<211>  906
<212>  DNA
<213>  Homo sapiens

<400>  7
atgatgcggc ccatcgtgct ggtgctgctg tttgccacat ctgccctggc cggctcccac       60

tccatgaggt atttctccac atccgtgtcc cggcccggcc gcggggagcc ccgcttcatc      120

gccgtgggct acgtggacga cacgcagttc gtgcggttcg acagcgacgc cgcgagccag      180

aggatggagc cgcgggcgcc gtggatagag caggaggggc cggagtattg ggacgaggag      240

acagggaaag tgaaggccca ctcacagact gaccgagaga acctgcggat cgcgctccgc      300

tactacaacc agagcgaggc cggttctcac accctccaga tgatgtttgg ctgcgacgtg      360

gggtcggacg ggcgcttcct ccgcgggtac caccagtacg cctacgacgg caaggattac      420

atcgccctga aagaggacct gcgctcttgg accgcggcgg acatggcggc tcagatcacc      480

aagcgcaagt gggaggcggc ccatgtggcg gagcagcaga gagcctacct ggagggcacg      540

tgcgtggacg ggctccgcag atacctggag aacgggaagg agacgctgca gcgcacggac      600

ccccccaaga cacatatgac ccaccacccc atctctgacc atgaggccac tctgagatgc      660

tgggccctgg gcttctaccc tgcggagatc acactgacct ggcagcggga tggggaggac      720

cagacccagg acacggagct tgtggagacc aggcctgcag gggatggaac cttccagaag      780

tgggcagctg tggtggtacc ttctggagag gagcagagat acacctgcca tgtgcagcat      840

gagggtctgc ccaagcccct caccctgaga tgggagccgg gcagccacca ccaccatcac      900

cattga                                                                 906


<210>  8
<211>  302
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Met Arg Pro Ile Val Leu Val Leu Leu Phe Ala Thr Ser Ala Leu 
1               5                   10                  15      


Ala Gly Ser His Ser Met Arg Tyr Phe Ser Thr Ser Val Ser Arg Pro 
            20                  25                  30          


Gly Arg Gly Glu Pro Arg Phe Ile Ala Val Gly Tyr Val Asp Asp Thr 
        35                  40                  45              


Gln Phe Val Arg Phe Asp Ser Asp Ala Ala Ser Gln Arg Met Glu Pro 
    50                  55                  60                  


Arg Ala Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Glu Glu 
65                  70                  75                  80  


Thr Gly Lys Val Lys Ala His Ser Gln Thr Asp Arg Glu Asn Leu Arg 
                85                  90                  95      


Ile Ala Leu Arg Tyr Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Leu 
            100                 105                 110         


Gln Met Met Phe Gly Cys Asp Val Gly Ser Asp Gly Arg Phe Leu Arg 
        115                 120                 125             


Gly Tyr His Gln Tyr Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Lys 
    130                 135                 140                 


Glu Asp Leu Arg Ser Trp Thr Ala Ala Asp Met Ala Ala Gln Ile Thr 
145                 150                 155                 160 


Lys Arg Lys Trp Glu Ala Ala His Val Ala Glu Gln Gln Arg Ala Tyr 
                165                 170                 175     


Leu Glu Gly Thr Cys Val Asp Gly Leu Arg Arg Tyr Leu Glu Asn Gly 
            180                 185                 190         


Lys Glu Thr Leu Gln Arg Thr Asp Pro Pro Lys Thr His Met Thr His 
        195                 200                 205             


His Pro Ile Ser Asp His Glu Ala Thr Leu Arg Cys Trp Ala Leu Gly 
    210                 215                 220                 


Phe Tyr Pro Ala Glu Ile Thr Leu Thr Trp Gln Arg Asp Gly Glu Asp 
225                 230                 235                 240 


Gln Thr Gln Asp Thr Glu Leu Val Glu Thr Arg Pro Ala Gly Asp Gly 
                245                 250                 255     


Thr Phe Gln Lys Trp Ala Ala Val Val Val Pro Ser Gly Glu Glu Gln 
            260                 265                 270         


Arg Tyr Thr Cys His Val Gln His Glu Gly Leu Pro Lys Pro Leu Thr 
        275                 280                 285             


Leu Arg Trp Glu Pro Gly Ser His His His His His His Glx 
    290                 295                 300         


<210>  9
<211>  906
<212>  DNA
<213>  Homo sapiens

<400>  9
atgatgcggc ccatcgtgct ggtgctgctg tttgccacat ctgccctggc cggctcccac       60

tccatgaggt atttctccac atccgtgtcc cggcccggcc gcggggagcc ccgcttcatc      120

gccgtgggct acgtggacga cacgcagttc gtgcggttcg acagcgacgc cgcgagccag      180

aggatggagc cgcgggcgcc gtggatagag caggaggggc cggagtattg ggacgaggag      240

acagggaaag tgaaggccca ctcacagact gaccgagaga acctgcggat cgcgctccgc      300

tactacaacc agagcgaggc cggttctcac accctccaga tgatgtttgg ctgcgacgtg      360

gggtcggacg ggcgcttcct ccgcgggtac caccagtacg cctacgacgg caaggattac      420

atcgccctga aagaggacct gcgctcttgg accgcggcgg acatggcggc tcagatcacc      480

aagcgcaagt gggaggcggc ccatgtggcg gagcagcaga gagcctacct ggagggcacg      540

tgcgtggacg ggctccgcag atacctggag aacgggaagg agacgctgca gcgcacagat      600

tccccaaagg cccatgtgac ccatcacagc agacctgaag ataaagtcac cctgaggtgc      660

tgggccctgg gcttctaccc tgctgacatc accctgacct ggcagttgaa tggggaggag      720

ctgatccagg acatggagct tgtggagacc aggcctgcag gggatggaac cttccagaag      780

tgggcatctg tggtggtgcc tcttgggaag gagcagtatt acacatgcca tgtgtaccat      840

caggggctgc ctgagcccct caccctgaga tgggagccgg gcagccacca ccaccatcac      900

cattga                                                                 906


<210>  10
<211>  302
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Met Arg Pro Ile Val Leu Val Leu Leu Phe Ala Thr Ser Ala Leu 
1               5                   10                  15      


Ala Gly Ser His Ser Met Arg Tyr Phe Ser Thr Ser Val Ser Arg Pro 
            20                  25                  30          


Gly Arg Gly Glu Pro Arg Phe Ile Ala Val Gly Tyr Val Asp Asp Thr 
        35                  40                  45              


Gln Phe Val Arg Phe Asp Ser Asp Ala Ala Ser Gln Arg Met Glu Pro 
    50                  55                  60                  


Arg Ala Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Glu Glu 
65                  70                  75                  80  


Thr Gly Lys Val Lys Ala His Ser Gln Thr Asp Arg Glu Asn Leu Arg 
                85                  90                  95      


Ile Ala Leu Arg Tyr Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Leu 
            100                 105                 110         


Gln Met Met Phe Gly Cys Asp Val Gly Ser Asp Gly Arg Phe Leu Arg 
        115                 120                 125             


Gly Tyr His Gln Tyr Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Lys 
    130                 135                 140                 


Glu Asp Leu Arg Ser Trp Thr Ala Ala Asp Met Ala Ala Gln Ile Thr 
145                 150                 155                 160 


Lys Arg Lys Trp Glu Ala Ala His Val Ala Glu Gln Gln Arg Ala Tyr 
                165                 170                 175     


Leu Glu Gly Thr Cys Val Asp Gly Leu Arg Arg Tyr Leu Glu Asn Gly 
            180                 185                 190         


Lys Glu Thr Leu Gln Arg Thr Asp Ser Pro Lys Ala His Val Thr His 
        195                 200                 205             


His Ser Arg Pro Glu Asp Lys Val Thr Leu Arg Cys Trp Ala Leu Gly 
    210                 215                 220                 


Phe Tyr Pro Ala Asp Ile Thr Leu Thr Trp Gln Leu Asn Gly Glu Glu 
225                 230                 235                 240 


Leu Ile Gln Asp Met Glu Leu Val Glu Thr Arg Pro Ala Gly Asp Gly 
                245                 250                 255     


Thr Phe Gln Lys Trp Ala Ser Val Val Val Pro Leu Gly Lys Glu Gln 
            260                 265                 270         


Tyr Tyr Thr Cys His Val Tyr His Gln Gly Leu Pro Glu Pro Leu Thr 
        275                 280                 285             


Leu Arg Trp Glu Pro Gly Ser His His His His His His Glx 
    290                 295                 300         


<210>  11
<211>  906
<212>  DNA
<213>  Homo sapiens

<400>  11
atgatgcggc ccatcgtgct ggtgctgctg tttgccacat ctgccctggc cggctcccac       60

tccatgaggt atttctccac atccgtgtcc cggcccggcc gcggggagcc ccgcttcatc      120

gccgtgggct acgtggacga cacgcagttc gtgcggttcg acagcgacgc cgcgagccag      180

aggatggagc cgcgggcgcc gtggatagag caggaggggc cggagtattg ggacgaggag      240

acagggaaag tgaaggccca ctcacagact gaccgagaga acctgcggat cgcgctccgc      300

tactacaacc agagcgaggc cggttctcac accctccaga tgatgtttgg ctgcgacgtg      360

gggtcggacg ggcgcttcct ccgcgggtac cacgagtacg cctacgacgg caaggattac      420

atcgccctga aagaggacct gcgctcttgg accgcggcgg acatggcggc tcagatcacc      480

aagcgcaagt gggaggcggc ccatgtggcg gagcagcaga gagcctacct ggagggcacg      540

tgcgtggacg ggctccgcag atacctggag aacgggaagg agacgctgca gcgcacagat      600

tccccaaagg cccatgtgac ccatcacagc agacctgaag ataaagtcac cctgaggtgc      660

tgggccctgg gcttctaccc tgctgacatc accctgacct ggcagttgaa tggggaggag      720

ctgatccagg acatggagct tgtggagacc aggcctgcag gggatggaac cttccagaag      780

tgggcatctg tggtggtgcc tcttgggaag gagcagtatt acacatgcca tgtgtaccat      840

caggggctgc ctgagcccct caccctgaga tgggagccgg gcagccacca ccaccatcac      900

cattga                                                                 906


<210>  12
<211>  302
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Met Arg Pro Ile Val Leu Val Leu Leu Phe Ala Thr Ser Ala Leu 
1               5                   10                  15      


Ala Gly Ser His Ser Met Arg Tyr Phe Ser Thr Ser Val Ser Arg Pro 
            20                  25                  30          


Gly Arg Gly Glu Pro Arg Phe Ile Ala Val Gly Tyr Val Asp Asp Thr 
        35                  40                  45              


Gln Phe Val Arg Phe Asp Ser Asp Ala Ala Ser Gln Arg Met Glu Pro 
    50                  55                  60                  


Arg Ala Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Glu Glu 
65                  70                  75                  80  


Thr Gly Lys Val Lys Ala His Ser Gln Thr Asp Arg Glu Asn Leu Arg 
                85                  90                  95      


Ile Ala Leu Arg Tyr Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Leu 
            100                 105                 110         


Gln Met Met Phe Gly Cys Asp Val Gly Ser Asp Gly Arg Phe Leu Arg 
        115                 120                 125             


Gly Tyr His Glu Tyr Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Lys 
    130                 135                 140                 


Glu Asp Leu Arg Ser Trp Thr Ala Ala Asp Met Ala Ala Gln Ile Thr 
145                 150                 155                 160 


Lys Arg Lys Trp Glu Ala Ala His Val Ala Glu Gln Gln Arg Ala Tyr 
                165                 170                 175     


Leu Glu Gly Thr Cys Val Asp Gly Leu Arg Arg Tyr Leu Glu Asn Gly 
            180                 185                 190         


Lys Glu Thr Leu Gln Arg Thr Asp Ser Pro Lys Ala His Val Thr His 
        195                 200                 205             


His Ser Arg Pro Glu Asp Lys Val Thr Leu Arg Cys Trp Ala Leu Gly 
    210                 215                 220                 


Phe Tyr Pro Ala Asp Ile Thr Leu Thr Trp Gln Leu Asn Gly Glu Glu 
225                 230                 235                 240 


Leu Ile Gln Asp Met Glu Leu Val Glu Thr Arg Pro Ala Gly Asp Gly 
                245                 250                 255     


Thr Phe Gln Lys Trp Ala Ser Val Val Val Pro Leu Gly Lys Glu Gln 
            260                 265                 270         


Tyr Tyr Thr Cys His Val Tyr His Gln Gly Leu Pro Glu Pro Leu Thr 
        275                 280                 285             


Leu Arg Trp Glu Pro Gly Ser His His His His His His Glx 
    290                 295                 300         


<210>  13
<211>  906
<212>  DNA
<213>  Homo sapiens

<400>  13
atgatgcggc ccatcgtgct ggtgctgctg tttgccacat ctgccctggc cggctcccac       60

tccatgaggt atttctacac cgccatgtcc cggcccggcc gcggggagcc ccgcttcatc      120

gcagtgggct acgtggacga cacccagttc gtgaggttcg acagcgacgc cgcgagtccg      180

aggacggagc cccgggcgcc atggatagag caggaggggc cggagtattg ggaccggaac      240

acacagatct tcaagaccaa cacacagact taccgagaga gcctgcggaa cctgcgcggc      300

tactacaacc agagcgaggc cgggtctcac atcatccaga ggatgtatgg ctgcgacctg      360

gggcccgacg ggcgcctcct ccgcgggcat gacgagtccg cctacgacgg caaggattac      420

atcgccctga acgaggacct gagctcctgg accgcggcgg acaccgcggc tcagatcacc      480

cagcgcaagt gggaggcggc ccgtgtggcg gagcagctga gagcctacct ggagggcctg      540

tgcgtggagt ggctccgcag atacctggag aacgggaagg agacgctgca gcgcacagat      600

tccccaaagg cccatgtgac ccatcacagc agacctgaag ataaagtcac cctgaggtgc      660

tgggccctgg gcttctaccc tgctgacatc accctgacct ggcagttgaa tggggaggag      720

ctgatccagg acatggagct tgtggagacc aggcctgcag gggatggaac cttccagaag      780

tgggcatctg tggtggtgcc tcttgggaag gagcagtatt acacatgcca tgtgtaccat      840

caggggctgc ctgagcccct caccctgaga tgggagccgg gcagccacca ccaccatcac      900

cattga                                                                 906


<210>  14
<211>  302
<212>  PRT
<213>  Homo sapiens

<400>  14

Met Met Arg Pro Ile Val Leu Val Leu Leu Phe Ala Thr Ser Ala Leu 
1               5                   10                  15      


Ala Gly Ser His Ser Met Arg Tyr Phe Tyr Thr Ala Met Ser Arg Pro 
            20                  25                  30          


Gly Arg Gly Glu Pro Arg Phe Ile Ala Val Gly Tyr Val Asp Asp Thr 
        35                  40                  45              


Gln Phe Val Arg Phe Asp Ser Asp Ala Ala Ser Pro Arg Thr Glu Pro 
    50                  55                  60                  


Arg Ala Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Arg Asn 
65                  70                  75                  80  


Thr Gln Ile Phe Lys Thr Asn Thr Gln Thr Tyr Arg Glu Ser Leu Arg 
                85                  90                  95      


Asn Leu Arg Gly Tyr Tyr Asn Gln Ser Glu Ala Gly Ser His Ile Ile 
            100                 105                 110         


Gln Arg Met Tyr Gly Cys Asp Leu Gly Pro Asp Gly Arg Leu Leu Arg 
        115                 120                 125             


Gly His Asp Glu Ser Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Asn 
    130                 135                 140                 


Glu Asp Leu Ser Ser Trp Thr Ala Ala Asp Thr Ala Ala Gln Ile Thr 
145                 150                 155                 160 


Gln Arg Lys Trp Glu Ala Ala Arg Val Ala Glu Gln Leu Arg Ala Tyr 
                165                 170                 175     


Leu Glu Gly Leu Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly 
            180                 185                 190         


Lys Glu Thr Leu Gln Arg Thr Asp Ser Pro Lys Ala His Val Thr His 
        195                 200                 205             


His Ser Arg Pro Glu Asp Lys Val Thr Leu Arg Cys Trp Ala Leu Gly 
    210                 215                 220                 


Phe Tyr Pro Ala Asp Ile Thr Leu Thr Trp Gln Leu Asn Gly Glu Glu 
225                 230                 235                 240 


Leu Ile Gln Asp Met Glu Leu Val Glu Thr Arg Pro Ala Gly Asp Gly 
                245                 250                 255     


Thr Phe Gln Lys Trp Ala Ser Val Val Val Pro Leu Gly Lys Glu Gln 
            260                 265                 270         


Tyr Tyr Thr Cys His Val Tyr His Gln Gly Leu Pro Glu Pro Leu Thr 
        275                 280                 285             


Leu Arg Trp Glu Pro Gly Ser His His His His His His Glx 
    290                 295                 300         


<210>  15
<211>  906
<212>  DNA
<213>  Homo sapiens

<400>  15
atgatgcggc ccatcgtgct ggtgctgctg tttgccacat ctgccctggc cggcagccac       60

agcatgcggt acttccacac cagcgtgtcc agacccggaa gaggcgagcc cagattcatc      120

accgtgggct acgtggacga caccctgttc gtcagattcg acagcgacgc caccagcccc      180

cggaaagaac ctagagcccc ttggatcgag caggaaggcc ccgagtactg ggacagagag      240

acacagatca gcaagaccaa cacccagacc tacagagaga gcctgcggaa cctgcggggc      300

tactacaatc agagcgaggc cggctctcac accctgcagt ctatgtacgg ctgcgacgtg      360

ggccccgatg gcagactgct gagaggccac aacgagtacg cctacgacgg caaggactat      420

atcgccctga acgaggacct gcggagctgg acagccgccg atacagccgc ccagatcacc      480

cagagaaagt gggaggccgc cagagtggcc gaacagctga gagcctatct ggaaggcgag      540

tgcgtggaat ggctgcggag atacctggaa aacggcaaag agacactgca gcgcacagat      600

tccccaaagg cccatgtgac ccatcacagc agacctgaag ataaagtcac cctgaggtgc      660

tgggccctgg gcttctaccc tgctgacatc accctgacct ggcagttgaa tggggaggag      720

ctgatccagg acatggagct tgtggagacc aggcctgcag gggatggaac cttccagaag      780

tgggcatctg tggtggtgcc tcttgggaag gagcagtatt acacatgcca tgtgtaccat      840

caggggctgc ctgagcccct caccctgaga tgggagccgg gcagccacca ccaccatcac      900

cattga                                                                 906


<210>  16
<211>  302
<212>  PRT
<213>  Homo sapiens

<400>  16

Met Met Arg Pro Ile Val Leu Val Leu Leu Phe Ala Thr Ser Ala Leu 
1               5                   10                  15      


Ala Gly Ser His Ser Met Arg Tyr Phe His Thr Ser Val Ser Arg Pro 
            20                  25                  30          


Gly Arg Gly Glu Pro Arg Phe Ile Thr Val Gly Tyr Val Asp Asp Thr 
        35                  40                  45              


Leu Phe Val Arg Phe Asp Ser Asp Ala Thr Ser Pro Arg Lys Glu Pro 
    50                  55                  60                  


Arg Ala Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Arg Glu 
65                  70                  75                  80  


Thr Gln Ile Ser Lys Thr Asn Thr Gln Thr Tyr Arg Glu Ser Leu Arg 
                85                  90                  95      


Asn Leu Arg Gly Tyr Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Leu 
            100                 105                 110         


Gln Ser Met Tyr Gly Cys Asp Val Gly Pro Asp Gly Arg Leu Leu Arg 
        115                 120                 125             


Gly His Asn Glu Tyr Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Asn 
    130                 135                 140                 


Glu Asp Leu Arg Ser Trp Thr Ala Ala Asp Thr Ala Ala Gln Ile Thr 
145                 150                 155                 160 


Gln Arg Lys Trp Glu Ala Ala Arg Val Ala Glu Gln Leu Arg Ala Tyr 
                165                 170                 175     


Leu Glu Gly Glu Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly 
            180                 185                 190         


Lys Glu Thr Leu Gln Arg Thr Asp Ser Pro Lys Ala His Val Thr His 
        195                 200                 205             


His Ser Arg Pro Glu Asp Lys Val Thr Leu Arg Cys Trp Ala Leu Gly 
    210                 215                 220                 


Phe Tyr Pro Ala Asp Ile Thr Leu Thr Trp Gln Leu Asn Gly Glu Glu 
225                 230                 235                 240 


Leu Ile Gln Asp Met Glu Leu Val Glu Thr Arg Pro Ala Gly Asp Gly 
                245                 250                 255     


Thr Phe Gln Lys Trp Ala Ser Val Val Val Pro Leu Gly Lys Glu Gln 
            260                 265                 270         


Tyr Tyr Thr Cys His Val Tyr His Gln Gly Leu Pro Glu Pro Leu Thr 
        275                 280                 285             


Leu Arg Trp Glu Pro Gly Ser His His His His His His Glx 
    290                 295                 300         


<210>  17
<211>  906
<212>  DNA
<213>  Homo sapiens

<400>  17
atgatgaggc ccatcgtgct ggtgctgctg ttcgccacat ctgccctggc cggcagccac       60

agcatgcggt acttttacac cgccatgagc agacccggca gaggcgagcc cagattcatc      120

accgtgggct acgtggacga caccctgttc gtcagattcg acagcgacgc caccagcccc      180

cggaaagaac ctagagcccc ttggatcgag caggaaggcc ccgagtactg ggacagagag      240

acacagatca gcaagaccaa cacccagacc tacagagaga acctgcggac cgccctgcgg      300

tactacaatc agtctgaggc cggctcccac atcatccagc ggatgtacgg ctgtgacgtg      360

ggccccgatg gcagactgct gagaggctac gacgagtacg cctacgacgg caaggactat      420

atcgccctga acgaggacct gagcagctgg acagccgccg atacagccgc ccagatcacc      480

cagagaaagt gggaggccgc cagagtggcc gagcaggata gagcctatct ggaaggcctg      540

tgcgtggaaa gcctgcggag atacctggaa aacggcaaag agacactgca gcgcacagat      600

tccccaaagg cccatgtgac ccatcacagc agacctgaag ataaagtcac cctgaggtgc      660

tgggccctgg gcttctaccc tgctgacatc accctgacct ggcagttgaa tggggaggag      720

ctgatccagg acatggagct tgtggagacc aggcctgcag gggatggaac cttccagaag      780

tgggcatctg tggtggtgcc tcttgggaag gagcagtatt acacatgcca tgtgtaccat      840

caggggctgc ctgagcccct caccctgaga tgggagccgg gcagccacca ccaccatcac      900

cattga                                                                 906


<210>  18
<211>  302
<212>  PRT
<213>  Homo sapiens

<400>  18

Met Met Arg Pro Ile Val Leu Val Leu Leu Phe Ala Thr Ser Ala Leu 
1               5                   10                  15      


Ala Gly Ser His Ser Met Arg Tyr Phe Tyr Thr Ala Met Ser Arg Pro 
            20                  25                  30          


Gly Arg Gly Glu Pro Arg Phe Ile Thr Val Gly Tyr Val Asp Asp Thr 
        35                  40                  45              


Leu Phe Val Arg Phe Asp Ser Asp Ala Thr Ser Pro Arg Lys Glu Pro 
    50                  55                  60                  


Arg Ala Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Arg Glu 
65                  70                  75                  80  


Thr Gln Ile Ser Lys Thr Asn Thr Gln Thr Tyr Arg Glu Asn Leu Arg 
                85                  90                  95      


Thr Ala Leu Arg Tyr Tyr Asn Gln Ser Glu Ala Gly Ser His Ile Ile 
            100                 105                 110         


Gln Arg Met Tyr Gly Cys Asp Val Gly Pro Asp Gly Arg Leu Leu Arg 
        115                 120                 125             


Gly Tyr Asp Glu Tyr Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Asn 
    130                 135                 140                 


Glu Asp Leu Ser Ser Trp Thr Ala Ala Asp Thr Ala Ala Gln Ile Thr 
145                 150                 155                 160 


Gln Arg Lys Trp Glu Ala Ala Arg Val Ala Glu Gln Asp Arg Ala Tyr 
                165                 170                 175     


Leu Glu Gly Leu Cys Val Glu Ser Leu Arg Arg Tyr Leu Glu Asn Gly 
            180                 185                 190         


Lys Glu Thr Leu Gln Arg Thr Asp Ser Pro Lys Ala His Val Thr His 
        195                 200                 205             


His Ser Arg Pro Glu Asp Lys Val Thr Leu Arg Cys Trp Ala Leu Gly 
    210                 215                 220                 


Phe Tyr Pro Ala Asp Ile Thr Leu Thr Trp Gln Leu Asn Gly Glu Glu 
225                 230                 235                 240 


Leu Ile Gln Asp Met Glu Leu Val Glu Thr Arg Pro Ala Gly Asp Gly 
                245                 250                 255     


Thr Phe Gln Lys Trp Ala Ser Val Val Val Pro Leu Gly Lys Glu Gln 
            260                 265                 270         


Tyr Tyr Thr Cys His Val Tyr His Gln Gly Leu Pro Glu Pro Leu Thr 
        275                 280                 285             


Leu Arg Trp Glu Pro Gly Ser His His His His His His Glx 
    290                 295                 300         


<210>  19
<211>  906
<212>  DNA
<213>  Homo sapiens

<400>  19
atgatgcggc ccatcgtgct ggtgctgctg tttgccacat ctgccctggc cggcagccac       60

agcatgcggt acttttacac cagcgtgtcc agacccggca gaggcgagcc cagattcatc      120

agcgtgggct acgtggacga cacccagttc gtcagattcg acagcgacgc cgccagcccc      180

agagaggaac ctagagcccc ttggatcgag caggaaggcc ccgagtactg ggaccggaac      240

acccagatct acaaggccca ggcccagacc gacagagaga gcctgagaaa cctgcggggc      300

tactacaacc agagcgaggc cggctctcac accctgcagt ctatgtacgg ctgcgacgtg      360

ggccccgatg gcagactgct gagaggccac gatgagtacg cctacgacgg caaggactat      420

atcgccctga acgaggacct gcggagctgg acagccgccg atacagccgc ccagatcacc      480

cagagaaagt gggaggccgc cagagaggcc gaacagagaa gggcctatct ggaaggcgag      540

tgcgtggaat ggctgcggag atacctggaa aatggcaagg acaagctgga acgcacagat      600

tccccaaagg cccatgtgac ccatcacagc agacctgaag ataaagtcac cctgaggtgc      660

tgggccctgg gcttctaccc tgctgacatc accctgacct ggcagttgaa tggggaggag      720

ctgatccagg acatggagct tgtggagacc aggcctgcag gggatggaac cttccagaag      780

tgggcatctg tggtggtgcc tcttgggaag gagcagtatt acacatgcca tgtgtaccat      840

caggggctgc ctgagcccct caccctgaga tgggagccgg gcagccacca ccaccatcac      900

cattga                                                                 906


<210>  20
<211>  302
<212>  PRT
<213>  Homo sapiens

<400>  20

Met Met Arg Pro Ile Val Leu Val Leu Leu Phe Ala Thr Ser Ala Leu 
1               5                   10                  15      


Ala Gly Ser His Ser Met Arg Tyr Phe Tyr Thr Ser Val Ser Arg Pro 
            20                  25                  30          


Gly Arg Gly Glu Pro Arg Phe Ile Ser Val Gly Tyr Val Asp Asp Thr 
        35                  40                  45              


Gln Phe Val Arg Phe Asp Ser Asp Ala Ala Ser Pro Arg Glu Glu Pro 
    50                  55                  60                  


Arg Ala Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Arg Asn 
65                  70                  75                  80  


Thr Gln Ile Tyr Lys Ala Gln Ala Gln Thr Asp Arg Glu Ser Leu Arg 
                85                  90                  95      


Asn Leu Arg Gly Tyr Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Leu 
            100                 105                 110         


Gln Ser Met Tyr Gly Cys Asp Val Gly Pro Asp Gly Arg Leu Leu Arg 
        115                 120                 125             


Gly His Asp Glu Tyr Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Asn 
    130                 135                 140                 


Glu Asp Leu Arg Ser Trp Thr Ala Ala Asp Thr Ala Ala Gln Ile Thr 
145                 150                 155                 160 


Gln Arg Lys Trp Glu Ala Ala Arg Glu Ala Glu Gln Arg Arg Ala Tyr 
                165                 170                 175     


Leu Glu Gly Glu Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly 
            180                 185                 190         


Lys Asp Lys Leu Glu Arg Thr Asp Ser Pro Lys Ala His Val Thr His 
        195                 200                 205             


His Ser Arg Pro Glu Asp Lys Val Thr Leu Arg Cys Trp Ala Leu Gly 
    210                 215                 220                 


Phe Tyr Pro Ala Asp Ile Thr Leu Thr Trp Gln Leu Asn Gly Glu Glu 
225                 230                 235                 240 


Leu Ile Gln Asp Met Glu Leu Val Glu Thr Arg Pro Ala Gly Asp Gly 
                245                 250                 255     


Thr Phe Gln Lys Trp Ala Ser Val Val Val Pro Leu Gly Lys Glu Gln 
            260                 265                 270         


Tyr Tyr Thr Cys His Val Tyr His Gln Gly Leu Pro Glu Pro Leu Thr 
        275                 280                 285             


Leu Arg Trp Glu Pro Gly Ser His His His His His His Glx 
    290                 295                 300         


<210>  21
<211>  906
<212>  DNA
<213>  Homo sapiens

<400>  21
atgatgcggc ccatcgtgct ggtgctgctg tttgccacat ctgccctggc cggcagccac       60

agcatgcggt actttgacac cgccatgagc agacccggca gaggcgagcc cagattcatc      120

agcgtgggct acgtggacga cacccagttc gtcagattcg acagcgacgc cgccagcccc      180

agagaggaac ctagagcccc ttggatcgag caggaaggcc ccgagtactg ggaccggaac      240

acccagatct tcaagaccaa tacccagacc gacagagaga gcctgcggaa cctgcggggc      300

tactacaatc agagcgaggc cggctctcac accctgcagt ctatgtacgg ctgcgacgtg      360

ggccccgatg gcagactgct gagaggccac aacgagtacg cctacgacgg caaggactat      420

atcgccctga acgaggacct gcggagctgg acagccgccg atacagccgc ccagatcacc      480

cagagaaagt gggaggccgc cagagtggcc gagcaggata gagcctacct ggaaggcacc      540

tgtgtggaat ggctgcggag atacctggaa aatggcaagg acaccctgga acgcacagat      600

tccccaaagg cccatgtgac ccatcacagc agacctgaag ataaagtcac cctgaggtgc      660

tgggccctgg gcttctaccc tgctgacatc accctgacct ggcagttgaa tggggaggag      720

ctgatccagg acatggagct tgtggagacc aggcctgcag gggatggaac cttccagaag      780

tgggcatctg tggtggtgcc tcttgggaag gagcagtatt acacatgcca tgtgtaccat      840

caggggctgc ctgagcccct caccctgaga tgggagccgg gcagccacca ccaccatcac      900

cattga                                                                 906


<210>  22
<211>  302
<212>  PRT
<213>  Homo sapiens

<400>  22

Met Met Arg Pro Ile Val Leu Val Leu Leu Phe Ala Thr Ser Ala Leu 
1               5                   10                  15      


Ala Gly Ser His Ser Met Arg Tyr Phe Asp Thr Ala Met Ser Arg Pro 
            20                  25                  30          


Gly Arg Gly Glu Pro Arg Phe Ile Ser Val Gly Tyr Val Asp Asp Thr 
        35                  40                  45              


Gln Phe Val Arg Phe Asp Ser Asp Ala Ala Ser Pro Arg Glu Glu Pro 
    50                  55                  60                  


Arg Ala Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Arg Asn 
65                  70                  75                  80  


Thr Gln Ile Phe Lys Thr Asn Thr Gln Thr Asp Arg Glu Ser Leu Arg 
                85                  90                  95      


Asn Leu Arg Gly Tyr Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Leu 
            100                 105                 110         


Gln Ser Met Tyr Gly Cys Asp Val Gly Pro Asp Gly Arg Leu Leu Arg 
        115                 120                 125             


Gly His Asn Glu Tyr Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Asn 
    130                 135                 140                 


Glu Asp Leu Arg Ser Trp Thr Ala Ala Asp Thr Ala Ala Gln Ile Thr 
145                 150                 155                 160 


Gln Arg Lys Trp Glu Ala Ala Arg Val Ala Glu Gln Asp Arg Ala Tyr 
                165                 170                 175     


Leu Glu Gly Thr Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly 
            180                 185                 190         


Lys Asp Thr Leu Glu Arg Thr Asp Ser Pro Lys Ala His Val Thr His 
        195                 200                 205             


His Ser Arg Pro Glu Asp Lys Val Thr Leu Arg Cys Trp Ala Leu Gly 
    210                 215                 220                 


Phe Tyr Pro Ala Asp Ile Thr Leu Thr Trp Gln Leu Asn Gly Glu Glu 
225                 230                 235                 240 


Leu Ile Gln Asp Met Glu Leu Val Glu Thr Arg Pro Ala Gly Asp Gly 
                245                 250                 255     


Thr Phe Gln Lys Trp Ala Ser Val Val Val Pro Leu Gly Lys Glu Gln 
            260                 265                 270         


Tyr Tyr Thr Cys His Val Tyr His Gln Gly Leu Pro Glu Pro Leu Thr 
        275                 280                 285             


Leu Arg Trp Glu Pro Gly Ser His His His His His His Glx 
    290                 295                 300         


<210>  23
<211>  906
<212>  DNA
<213>  Homo sapiens

<400>  23
atgatgcggc ccatcgtgct ggtgctgctg tttgccacaa gcgccctggc ctgctctcac       60

agcatgcgct atttttacac ggcagttagt cggcctggga ggggtgagcc gagattcatt      120

gctgtaggct acgtagacga cactcaattt gtacagttcg actcagacgc tgcttcaccg      180

cgaggagagc ccagggcacc ctgggtagaa caagaagggc ccgaatactg ggatcgagaa      240

acccagaagt ataagaggca agcacaaact gatcgggtca acttgagaaa actgcgaggc      300

tactataatc aaagtgaggc aggatcccat acacttcaga ggatgtatgg ctgcgacctt      360

ggtccagatg gccggctcct cagagggtat aacgaatttg catacgacgg gaaggattac      420

atagctctca atgaggacct tagatcatgg acggcagcgg ataaggcagc ccaaattact      480

caaaggaaat gggaggcggc ccgagaagca gagcagagaa gagcctacct ggaaggtaca      540

tgcgtggagt ggcttcggcg ctatctcgaa aacggtaaaa agacattgca acgcacagat      600

tccccaaagg cccatgtgac ccatcacagc agacctgaag ataaagtcac cctgaggtgc      660

tgggccctgg gcttctaccc tgctgacatc accctgacct ggcagttgaa tggggaggag      720

ctgatccagg acatggagct tgtggagacc aggcctgcag gggatggaac cttccagaag      780

tgggcatctg tggtggtgcc tcttgggaag gagcagtatt acacatgcca tgtgtaccat      840

caggggctgc ctgagcccct caccctgaga tgggagccgg gcagccacca ccaccatcac      900

cattga                                                                 906


<210>  24
<211>  302
<212>  PRT
<213>  Homo sapiens

<400>  24

Met Met Arg Pro Ile Val Leu Val Leu Leu Phe Ala Thr Ser Ala Leu 
1               5                   10                  15      


Ala Cys Ser His Ser Met Arg Tyr Phe Tyr Thr Ala Val Ser Arg Pro 
            20                  25                  30          


Gly Arg Gly Glu Pro Arg Phe Ile Ala Val Gly Tyr Val Asp Asp Thr 
        35                  40                  45              


Gln Phe Val Gln Phe Asp Ser Asp Ala Ala Ser Pro Arg Gly Glu Pro 
    50                  55                  60                  


Arg Ala Pro Trp Val Glu Gln Glu Gly Pro Glu Tyr Trp Asp Arg Glu 
65                  70                  75                  80  


Thr Gln Lys Tyr Lys Arg Gln Ala Gln Thr Asp Arg Val Asn Leu Arg 
                85                  90                  95      


Lys Leu Arg Gly Tyr Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Leu 
            100                 105                 110         


Gln Arg Met Tyr Gly Cys Asp Leu Gly Pro Asp Gly Arg Leu Leu Arg 
        115                 120                 125             


Gly Tyr Asn Glu Phe Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Asn 
    130                 135                 140                 


Glu Asp Leu Arg Ser Trp Thr Ala Ala Asp Lys Ala Ala Gln Ile Thr 
145                 150                 155                 160 


Gln Arg Lys Trp Glu Ala Ala Arg Glu Ala Glu Gln Arg Arg Ala Tyr 
                165                 170                 175     


Leu Glu Gly Thr Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly 
            180                 185                 190         


Lys Lys Thr Leu Gln Arg Thr Asp Ser Pro Lys Ala His Val Thr His 
        195                 200                 205             


His Ser Arg Pro Glu Asp Lys Val Thr Leu Arg Cys Trp Ala Leu Gly 
    210                 215                 220                 


Phe Tyr Pro Ala Asp Ile Thr Leu Thr Trp Gln Leu Asn Gly Glu Glu 
225                 230                 235                 240 


Leu Ile Gln Asp Met Glu Leu Val Glu Thr Arg Pro Ala Gly Asp Gly 
                245                 250                 255     


Thr Phe Gln Lys Trp Ala Ser Val Val Val Pro Leu Gly Lys Glu Gln 
            260                 265                 270         


Tyr Tyr Thr Cys His Val Tyr His Gln Gly Leu Pro Glu Pro Leu Thr 
        275                 280                 285             


Leu Arg Trp Glu Pro Gly Ser His His His His His His Glx 
    290                 295                 300         


<210>  25
<211>  906
<212>  DNA
<213>  Homo sapiens

<400>  25
atgatgcggc ccatcgtgct ggtgctgctg tttgccacaa gcgccctggc ctgcagccac       60

agcatgcggt actttgacac cgccgtgtcc agacccggaa gaggcgagcc cagattcatc      120

agcgtgggct acgtggacga cacccagttc gtcagattcg acagcgacgc cgccagcccc      180

agaggcgaac ctagagcacc ttgggtggaa caggaaggcc ccgagtactg ggacagagag      240

acacagaact acaagcggca ggcccaggcc gacagagtgt ccctgagaaa cctgcggggc      300

tactacaacc agagcgagga cggcagccac accctgcaga gaatgtacgg ctgtgacctg      360

ggccccgatg gcagactgct gagaggctac gatgagagcg cctacgacgg caaggactat      420

atcgccctga acgaggacct gcggagctgg acagccgccg atacagccgc ccagatcacc      480

cagagaaaac tggaagccgc cagagccgcc gagcagctga gagcttatct ggaaggcacc      540

tgtgtggaat ggctgcggag atacctggaa aacggcaaag agacactgca gcgcacagat      600

tccccaaagg cccatgtgac ccatcacagc agacctgaag ataaagtcac cctgaggtgc      660

tgggccctgg gcttctaccc tgctgacatc accctgacct ggcagttgaa tggggaggag      720

ctgatccagg acatggagct tgtggagacc aggcctgcag gggatggaac cttccagaag      780

tgggcatctg tggtggtgcc tcttgggaag gagcagtatt acacatgcca tgtgtaccat      840

caggggctgc ctgagcccct caccctgaga tgggagccgg gcagccacca ccaccatcac      900

cattga                                                                 906


<210>  26
<211>  302
<212>  PRT
<213>  Homo sapiens

<400>  26

Met Met Arg Pro Ile Val Leu Val Leu Leu Phe Ala Thr Ser Ala Leu 
1               5                   10                  15      


Ala Cys Ser His Ser Met Arg Tyr Phe Asp Thr Ala Val Ser Arg Pro 
            20                  25                  30          


Gly Arg Gly Glu Pro Arg Phe Ile Ser Val Gly Tyr Val Asp Asp Thr 
        35                  40                  45              


Gln Phe Val Arg Phe Asp Ser Asp Ala Ala Ser Pro Arg Gly Glu Pro 
    50                  55                  60                  


Arg Ala Pro Trp Val Glu Gln Glu Gly Pro Glu Tyr Trp Asp Arg Glu 
65                  70                  75                  80  


Thr Gln Asn Tyr Lys Arg Gln Ala Gln Ala Asp Arg Val Ser Leu Arg 
                85                  90                  95      


Asn Leu Arg Gly Tyr Tyr Asn Gln Ser Glu Asp Gly Ser His Thr Leu 
            100                 105                 110         


Gln Arg Met Tyr Gly Cys Asp Leu Gly Pro Asp Gly Arg Leu Leu Arg 
        115                 120                 125             


Gly Tyr Asp Glu Ser Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Asn 
    130                 135                 140                 


Glu Asp Leu Arg Ser Trp Thr Ala Ala Asp Thr Ala Ala Gln Ile Thr 
145                 150                 155                 160 


Gln Arg Lys Leu Glu Ala Ala Arg Ala Ala Glu Gln Leu Arg Ala Tyr 
                165                 170                 175     


Leu Glu Gly Thr Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly 
            180                 185                 190         


Lys Glu Thr Leu Gln Arg Thr Asp Ser Pro Lys Ala His Val Thr His 
        195                 200                 205             


His Ser Arg Pro Glu Asp Lys Val Thr Leu Arg Cys Trp Ala Leu Gly 
    210                 215                 220                 


Phe Tyr Pro Ala Asp Ile Thr Leu Thr Trp Gln Leu Asn Gly Glu Glu 
225                 230                 235                 240 


Leu Ile Gln Asp Met Glu Leu Val Glu Thr Arg Pro Ala Gly Asp Gly 
                245                 250                 255     


Thr Phe Gln Lys Trp Ala Ser Val Val Val Pro Leu Gly Lys Glu Gln 
            260                 265                 270         


Tyr Tyr Thr Cys His Val Tyr His Gln Gly Leu Pro Glu Pro Leu Thr 
        275                 280                 285             


Leu Arg Trp Glu Pro Gly Ser His His His His His His Glx 
    290                 295                 300         


<210>  27
<211>  906
<212>  DNA
<213>  Homo sapiens

<400>  27
atgatgcggc ccatcgtgct ggtgctgctg tttgccacat ctgccctggc ctgcagccac       60

agcatgcggt actttgacac cgccgtgtcc agacccggaa gaggcgagcc cagattcatc      120

agcgtgggct acgtggacga cacccagttc gtcagattcg acagcgacgc cgccagcccc      180

agaggcgaac ctagagcacc ttgggtggaa caggaaggcc ccgagtactg ggacagagag      240

acacagaagt acaagcggca ggcccaggcc gacagagtgt ccctgagaaa cctgcggggc      300

tactacaacc agagcgagga cggcagccac accctgcaga gaatgagcgg ctgtgacctg      360

ggccccgatg gcagactgct gagaggctac gatgagagcg cctacgacgg caaggactat      420

atcgccctga acgaggacct gcggagctgg acagccgccg atacagccgc ccagatcacc      480

cagagaaaac tggaagccgc cagagccgcc gagcagctga gagcttatct ggaaggcacc      540

tgtgtggaat ggctgcggag atacctggaa aacggcaaag agacactgca gcgcacagat      600

tccccaaagg cccatgtgac ccatcacagc agacctgaag ataaagtcac cctgaggtgc      660

tgggccctgg gcttctaccc tgctgacatc accctgacct ggcagttgaa tggggaggag      720

ctgatccagg acatggagct tgtggagacc aggcctgcag gggatggaac cttccagaag      780

tgggcatctg tggtggtgcc tcttgggaag gagcagtatt acacatgcca tgtgtaccat      840

caggggctgc ctgagcccct caccctgaga tgggagccgg gcagccacca ccaccatcac      900

cattga                                                                 906


<210>  28
<211>  302
<212>  PRT
<213>  Homo sapiens

<400>  28

Met Met Arg Pro Ile Val Leu Val Leu Leu Phe Ala Thr Ser Ala Leu 
1               5                   10                  15      


Ala Cys Ser His Ser Met Arg Tyr Phe Asp Thr Ala Val Ser Arg Pro 
            20                  25                  30          


Gly Arg Gly Glu Pro Arg Phe Ile Ser Val Gly Tyr Val Asp Asp Thr 
        35                  40                  45              


Gln Phe Val Arg Phe Asp Ser Asp Ala Ala Ser Pro Arg Gly Glu Pro 
    50                  55                  60                  


Arg Ala Pro Trp Val Glu Gln Glu Gly Pro Glu Tyr Trp Asp Arg Glu 
65                  70                  75                  80  


Thr Gln Lys Tyr Lys Arg Gln Ala Gln Ala Asp Arg Val Ser Leu Arg 
                85                  90                  95      


Asn Leu Arg Gly Tyr Tyr Asn Gln Ser Glu Asp Gly Ser His Thr Leu 
            100                 105                 110         


Gln Arg Met Ser Gly Cys Asp Leu Gly Pro Asp Gly Arg Leu Leu Arg 
        115                 120                 125             


Gly Tyr Asp Glu Ser Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Asn 
    130                 135                 140                 


Glu Asp Leu Arg Ser Trp Thr Ala Ala Asp Thr Ala Ala Gln Ile Thr 
145                 150                 155                 160 


Gln Arg Lys Leu Glu Ala Ala Arg Ala Ala Glu Gln Leu Arg Ala Tyr 
                165                 170                 175     


Leu Glu Gly Thr Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly 
            180                 185                 190         


Lys Glu Thr Leu Gln Arg Thr Asp Ser Pro Lys Ala His Val Thr His 
        195                 200                 205             


His Ser Arg Pro Glu Asp Lys Val Thr Leu Arg Cys Trp Ala Leu Gly 
    210                 215                 220                 


Phe Tyr Pro Ala Asp Ile Thr Leu Thr Trp Gln Leu Asn Gly Glu Glu 
225                 230                 235                 240 


Leu Ile Gln Asp Met Glu Leu Val Glu Thr Arg Pro Ala Gly Asp Gly 
                245                 250                 255     


Thr Phe Gln Lys Trp Ala Ser Val Val Val Pro Leu Gly Lys Glu Gln 
            260                 265                 270         


Tyr Tyr Thr Cys His Val Tyr His Gln Gly Leu Pro Glu Pro Leu Thr 
        275                 280                 285             


Leu Arg Trp Glu Pro Gly Ser His His His His His His Glx 
    290                 295                 300         


<210>  29
<211>  906
<212>  DNA
<213>  Homo sapiens

<400>  29
atgatgaggc ccatcgtgct ggtgctgctg ttcgccacat ctgccctggc ctgcagccac       60

agcatgcggt acttttacac cgccgtgtcc agacccggca gaggcgagcc tagattcatt      120

gccgtgggct acgtggacga cacccagttc gtcagattcg acagcgacgc cgccagcccc      180

agaggggaac ctagagcacc ttgggtggaa caggaaggcc ccgagtactg ggacagagag      240

acacagaagt acaagcggca ggcccagacc gaccgggtgt ccctgagaaa cctgcggggc      300

tactacaacc agagcgaggc cggctctcac accctgcagt ggatgtacgg ctgcgacctg      360

ggccctgatg gcagactgct gagaggctac gacgagtccg cctacgacgg caaggactat      420

atcgccctga acgaggacct gcggagctgg acagccgccg atacagccgc ccagatcacc      480

cagagaaagt gggaagccgc cagagccgcc gagcagcaga gagcttatct ggaaggcacc      540

tgtgtggaat ggctgcggag atacctggaa aacggcaaag agacactgca gcgcacagat      600

tccccaaagg cccatgtgac ccatcacagc agacctgaag ataaagtcac cctgaggtgc      660

tgggccctgg gcttctaccc tgctgacatc accctgacct ggcagttgaa tggggaggag      720

ctgatccagg acatggagct tgtggagacc aggcctgcag gggatggaac cttccagaag      780

tgggcatctg tggtggtgcc tcttgggaag gagcagtatt acacatgcca tgtgtaccat      840

caggggctgc ctgagcccct caccctgaga tgggagccgg gcagccacca ccaccatcac      900

cattga                                                                 906


<210>  30
<211>  302
<212>  PRT
<213>  Homo sapiens

<400>  30

Met Met Arg Pro Ile Val Leu Val Leu Leu Phe Ala Thr Ser Ala Leu 
1               5                   10                  15      


Ala Cys Ser His Ser Met Arg Tyr Phe Tyr Thr Ala Val Ser Arg Pro 
            20                  25                  30          


Gly Arg Gly Glu Pro Arg Phe Ile Ala Val Gly Tyr Val Asp Asp Thr 
        35                  40                  45              


Gln Phe Val Arg Phe Asp Ser Asp Ala Ala Ser Pro Arg Gly Glu Pro 
    50                  55                  60                  


Arg Ala Pro Trp Val Glu Gln Glu Gly Pro Glu Tyr Trp Asp Arg Glu 
65                  70                  75                  80  


Thr Gln Lys Tyr Lys Arg Gln Ala Gln Thr Asp Arg Val Ser Leu Arg 
                85                  90                  95      


Asn Leu Arg Gly Tyr Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Leu 
            100                 105                 110         


Gln Trp Met Tyr Gly Cys Asp Leu Gly Pro Asp Gly Arg Leu Leu Arg 
        115                 120                 125             


Gly Tyr Asp Glu Ser Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Asn 
    130                 135                 140                 


Glu Asp Leu Arg Ser Trp Thr Ala Ala Asp Thr Ala Ala Gln Ile Thr 
145                 150                 155                 160 


Gln Arg Lys Trp Glu Ala Ala Arg Ala Ala Glu Gln Gln Arg Ala Tyr 
                165                 170                 175     


Leu Glu Gly Thr Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly 
            180                 185                 190         


Lys Glu Thr Leu Gln Arg Thr Asp Ser Pro Lys Ala His Val Thr His 
        195                 200                 205             


His Ser Arg Pro Glu Asp Lys Val Thr Leu Arg Cys Trp Ala Leu Gly 
    210                 215                 220                 


Phe Tyr Pro Ala Asp Ile Thr Leu Thr Trp Gln Leu Asn Gly Glu Glu 
225                 230                 235                 240 


Leu Ile Gln Asp Met Glu Leu Val Glu Thr Arg Pro Ala Gly Asp Gly 
                245                 250                 255     


Thr Phe Gln Lys Trp Ala Ser Val Val Val Pro Leu Gly Lys Glu Gln 
            260                 265                 270         


Tyr Tyr Thr Cys His Val Tyr His Gln Gly Leu Pro Glu Pro Leu Thr 
        275                 280                 285             


Leu Arg Trp Glu Pro Gly Ser His His His His His His Glx 
    290                 295                 300         


<210>  31
<211>  906
<212>  DNA
<213>  Homo sapiens

<400>  31
atgatgcggc ccatcgtgct ggtgctgctg tttgccacat ctgccctggc cggctcccac       60

tccatgaggt atttctacac cgccatgtcc cggcccggcc gcggggagcc ccgcttcatc      120

gcagtgggct acgtggacga cacccagttc gtgaggttcg acagcgacgc cgcgagtccg      180

aggacggagc cccgggcgcc atggatagag caggaggggc cggagtattg ggaccggaac      240

acacagatct tcaagaccaa cacacagact taccgagaga gcctgcggaa cctgcgcggc      300

tactacaacc agagcgaggc cgggtctcac atcatccaga ggatgtatgg ctgcgacctg      360

gggcccgacg ggcgcctcct ccgcgggcat gaccagtccg cctacgacgg caaggattac      420

atcgccctga acgaggacct gagctcctgg accgcggcgg acaccgcggc tcagatcacc      480

cagcgcaagt gggaggcggc ccgtgtggcg gagcagctga gagcctacct ggagggcctg      540

tgcgtggagt ggctccgcag atacctggag aacgggaagg agacgctgca gcgcgcggac      600

cccccaaaga cacacgtgac ccaccacccc gtctctgacc atgaggccac cctgaggtgc      660

tgggccctgg gcttctaccc tgcggagatc acactgacct ggcagcggga tggcgaggac      720

caaactcagg acactgagct tgtggagacc agaccagcag gagatagaac cttccagaag      780

tgggcagctg tggtggtgcc ttctggagaa gagcagagat acacatgcca tgtacagcat      840

gaggggctgc ccaagcccct caccctgaga tgggagccgg gcagccacca ccaccatcac      900

cattga                                                                 906


<210>  32
<211>  302
<212>  PRT
<213>  Homo sapiens

<400>  32

Met Met Arg Pro Ile Val Leu Val Leu Leu Phe Ala Thr Ser Ala Leu 
1               5                   10                  15      


Ala Gly Ser His Ser Met Arg Tyr Phe Tyr Thr Ala Met Ser Arg Pro 
            20                  25                  30          


Gly Arg Gly Glu Pro Arg Phe Ile Ala Val Gly Tyr Val Asp Asp Thr 
        35                  40                  45              


Gln Phe Val Arg Phe Asp Ser Asp Ala Ala Ser Pro Arg Thr Glu Pro 
    50                  55                  60                  


Arg Ala Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Arg Asn 
65                  70                  75                  80  


Thr Gln Ile Phe Lys Thr Asn Thr Gln Thr Tyr Arg Glu Ser Leu Arg 
                85                  90                  95      


Asn Leu Arg Gly Tyr Tyr Asn Gln Ser Glu Ala Gly Ser His Ile Ile 
            100                 105                 110         


Gln Arg Met Tyr Gly Cys Asp Leu Gly Pro Asp Gly Arg Leu Leu Arg 
        115                 120                 125             


Gly His Asp Gln Ser Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Asn 
    130                 135                 140                 


Glu Asp Leu Ser Ser Trp Thr Ala Ala Asp Thr Ala Ala Gln Ile Thr 
145                 150                 155                 160 


Gln Arg Lys Trp Glu Ala Ala Arg Val Ala Glu Gln Leu Arg Ala Tyr 
                165                 170                 175     


Leu Glu Gly Leu Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly 
            180                 185                 190         


Lys Glu Thr Leu Gln Arg Ala Asp Pro Pro Lys Thr His Val Thr His 
        195                 200                 205             


His Pro Val Ser Asp His Glu Ala Thr Leu Arg Cys Trp Ala Leu Gly 
    210                 215                 220                 


Phe Tyr Pro Ala Glu Ile Thr Leu Thr Trp Gln Arg Asp Gly Glu Asp 
225                 230                 235                 240 


Gln Thr Gln Asp Thr Glu Leu Val Glu Thr Arg Pro Ala Gly Asp Arg 
                245                 250                 255     


Thr Phe Gln Lys Trp Ala Ala Val Val Val Pro Ser Gly Glu Glu Gln 
            260                 265                 270         


Arg Tyr Thr Cys His Val Gln His Glu Gly Leu Pro Lys Pro Leu Thr 
        275                 280                 285             


Leu Arg Trp Glu Pro Gly Ser His His His His His His Glx 
    290                 295                 300         


<210>  33
<211>  906
<212>  DNA
<213>  Homo sapiens

<400>  33
atgatgcggc ccatcgtgct ggtgctgctg tttgccacat ctgccctggc cggctcccac       60

tccatgaggt atttctacac cgccatgtcc cggcccggcc gcggggagcc ccgcttcatc      120

gcagtgggct acgtggacga cacccagttc gtgaggttcg acagcgacgc cgcgagtccg      180

aggacggagc cccgggcgcc atggatagag caggaggggc cggagtattg ggaccggaac      240

acacagatct tcaagaccaa cacacagact taccgagaga gcctgcggaa cctgcgcggc      300

tactacaacc agagcgaggc cgggtctcac atcatccaga ggatgtatgg ctgcgacctg      360

gggcccgacg ggcgcctcct ccgcgggcat gaccagtccg cctacgacgg caaggattac      420

atcgccctga acgaggacct gagctcctgg accgcggcgg acaccgcggc tcagatcacc      480

cagcgcaagt gggaggcggc ccgtgtggcg gagcagctga gagcctacct ggagggcctg      540

tgcgtggagt ggctccgcag atacctggag aacgggaagg agacgctgca gcgcacagat      600

tccccaaagg cccatgtgac ccatcacagc agacctgaag ataaagtcac cctgaggtgc      660

tgggccctgg gcttctaccc tgctgacatc accctgacct ggcagttgaa tggggaggag      720

ctgatccagg acatggagct tgtggagacc aggcctgcag gggatggaac cttccagaag      780

tgggcatctg tggtggtgcc tcttgggaag gagcagtatt acacatgcca tgtgtaccat      840

caggggctgc ctgagcccct caccctgaga tgggagccgg gcagccacca ccaccatcac      900

cattga                                                                 906


<210>  34
<211>  302
<212>  PRT
<213>  Homo sapiens

<400>  34

Met Met Arg Pro Ile Val Leu Val Leu Leu Phe Ala Thr Ser Ala Leu 
1               5                   10                  15      


Ala Gly Ser His Ser Met Arg Tyr Phe Tyr Thr Ala Met Ser Arg Pro 
            20                  25                  30          


Gly Arg Gly Glu Pro Arg Phe Ile Ala Val Gly Tyr Val Asp Asp Thr 
        35                  40                  45              


Gln Phe Val Arg Phe Asp Ser Asp Ala Ala Ser Pro Arg Thr Glu Pro 
    50                  55                  60                  


Arg Ala Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Arg Asn 
65                  70                  75                  80  


Thr Gln Ile Phe Lys Thr Asn Thr Gln Thr Tyr Arg Glu Ser Leu Arg 
                85                  90                  95      


Asn Leu Arg Gly Tyr Tyr Asn Gln Ser Glu Ala Gly Ser His Ile Ile 
            100                 105                 110         


Gln Arg Met Tyr Gly Cys Asp Leu Gly Pro Asp Gly Arg Leu Leu Arg 
        115                 120                 125             


Gly His Asp Gln Ser Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Asn 
    130                 135                 140                 


Glu Asp Leu Ser Ser Trp Thr Ala Ala Asp Thr Ala Ala Gln Ile Thr 
145                 150                 155                 160 


Gln Arg Lys Trp Glu Ala Ala Arg Val Ala Glu Gln Leu Arg Ala Tyr 
                165                 170                 175     


Leu Glu Gly Leu Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly 
            180                 185                 190         


Lys Glu Thr Leu Gln Arg Thr Asp Ser Pro Lys Ala His Val Thr His 
        195                 200                 205             


His Ser Arg Pro Glu Asp Lys Val Thr Leu Arg Cys Trp Ala Leu Gly 
    210                 215                 220                 


Phe Tyr Pro Ala Asp Ile Thr Leu Thr Trp Gln Leu Asn Gly Glu Glu 
225                 230                 235                 240 


Leu Ile Gln Asp Met Glu Leu Val Glu Thr Arg Pro Ala Gly Asp Gly 
                245                 250                 255     


Thr Phe Gln Lys Trp Ala Ser Val Val Val Pro Leu Gly Lys Glu Gln 
            260                 265                 270         


Tyr Tyr Thr Cys His Val Tyr His Gln Gly Leu Pro Glu Pro Leu Thr 
        275                 280                 285             


Leu Arg Trp Glu Pro Gly Ser His His His His His His Glx 
    290                 295                 300         


<210>  35
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide fragment

<400>  35

Val Leu Asp Phe Ala Pro Pro Gly Ala 
1               5                   


<210>  36
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide fragment

<400>  36

Arg Met Phe Pro Asn Ala Pro Tyr Leu 
1               5                   


<210>  37
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide fragment

<400>  37

Ser Leu Gly Glu Gln Gln Tyr Ser Val 
1               5                   


<210>  38
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide fragment

<400>  38

Cys Met Thr Trp Asn Gln Met Asn Leu 
1               5                   


<210>  39
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide fragment

<400>  39

Tyr Met Ala Pro Asp Cys Arg Phe Leu 
1               5                   


<210>  40
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide fragment

<400>  40

Arg Leu Gly Tyr Phe Pro Ser Ser Ile 
1               5                   


<210>  41
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide fragment

<400>  41

Leu Gln Leu Glu Glu Leu Glu Lys Val 
1               5                   


<210>  42
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide fragment

<400>  42

Glu Leu Thr Glu Ala Arg Val Gln Val 
1               5                   


<210>  43
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide fragment

<400>  43

Phe Leu Gly Asp Thr His Ser Ser Ile 
1               5                   


<210>  44
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide fragment

<400>  44

Ile Leu Ala Tyr Thr Glu Asp Glu Val 
1               5                   


<210>  45
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide fragment

<400>  45

Phe Leu Glu Glu Ile Lys Glu Gln Glu Val 
1               5                   10  


<210>  46
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide fragment

<400>  46

Phe Met Ala Phe Val Ala Met Val Thr 
1               5                   


<210>  47
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide fragment

<400>  47

Leu Leu Asp Glu Ala Thr Ser Ala Leu 
1               5                   


<210>  48
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide fragment

<400>  48

Val Leu Asn Gly Thr Val His Pro Val 
1               5                   


<210>  49
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide fragment

<400>  49

Val Leu Leu Ser Pro Arg Trp Glu Leu 
1               5                   


<210>  50
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide fragment

<400>  50

Phe Leu Trp Asp Ala Tyr Phe Ser Ser 
1               5                   


<210>  51
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide fragment

<400>  51

Trp Leu Ala Leu Ser Ala Ser Trp Leu 
1               5                   


<210>  52
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide fragment

<400>  52

Leu Leu Leu Pro Gly Ile Tyr Thr Val 
1               5                   


<210>  53
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide fragment

<400>  53

Lys Leu Phe Gln Lys Leu Ala Lys Val 
1               5                   


<210>  54
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide fragment

<400>  54

Tyr Leu His Thr Asn Cys Phe Glu Ile 
1               5                   


<210>  55
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide fragment

<400>  55

Phe Leu Ser Asn Phe Pro Phe Ser Leu 
1               5                   


<210>  56
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide fragment

<400>  56

Ala Leu Ala Ile Gly Leu Trp Gly Leu 
1               5                   


<210>  57
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide fragment

<400>  57

Ala Leu Cys Glu Asn Thr Cys Leu Leu 
1               5                   


<210>  58
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide fragment

<400>  58

Leu Leu Tyr Pro Gly Tyr Ala Met Val 
1               5                   


<210>  59
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide fragment

<400>  59

Gly Leu Tyr Thr Leu Leu Ser Gly Val 
1               5                   


<210>  60
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide fragment

<400>  60

Ala Val Phe Met Tyr Val Phe Tyr Leu 
1               5                   


<210>  61
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide fragment

<400>  61

Leu Met Asp Asp Thr Leu Ser Pro Val 
1               5                   


<210>  62
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide fragment

<400>  62

Leu Gln Met Ala Asn Thr Leu Pro Val 
1               5                   


<210>  63
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide fragment

<400>  63

Leu Leu Ser Ser Val Ser Pro Gly Ala 
1               5                   


<210>  64
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide fragment

<400>  64

Ser Gln Phe Val Phe Ser Phe Pro Val 
1               5                   


<210>  65
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide fragment

<400>  65

Gln Leu Leu Gln Phe Glu Ser Gln Val 
1               5                   


<210>  66
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide fragment

<400>  66

Phe Leu Ala His Ser Ala Gly Tyr Ile 
1               5                   


<210>  67
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide fragment

<400>  67

Phe Leu Asp Arg Phe Leu Ser Cys Met 
1               5                   


<210>  68
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide fragment

<400>  68

Ser Leu Ile Ala Ala Ala Ala Phe Cys Leu Ala 
1               5                   10      


<210>  69
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide fragment

<400>  69

Met Leu Ala Val Ile Ser Cys Ala Val 
1               5                   


<210>  70
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide fragment

<400>  70

Met Leu Met Ala Gln Glu Ala Leu Ala Phe Leu 
1               5                   10      


<210>  71
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide fragment

<400>  71

Lys Val Leu Glu Tyr Val Ile Lys Val 
1               5                   


<210>  72
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide fragment

<400>  72

Tyr Leu Gln Leu Val Phe Gly Ile Glu Val 
1               5                   10  


<210>  73
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide fragment

<400>  73

Phe Leu Trp Gly Pro Arg Ala Leu Val 
1               5                   


<210>  74
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide fragment

<400>  74

Lys Val Ala Glu Leu Val His Phe Leu 
1               5                   


<210>  75
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide fragment

<400>  75

Gly Val Tyr Asp Gly Arg Glu His Thr Val 
1               5                   10  


<210>  76
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide fragment

<400>  76

Ala Leu Ser Val Met Gly Val Tyr Val 
1               5                   


<210>  77
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide fragment

<400>  77

Gly Leu Tyr Asp Gly Met Glu His Leu 
1               5                   


<210>  78
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide fragment

<400>  78

Phe Leu Trp Gly Pro Arg Ala Leu Val 
1               5                   


<210>  79
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide fragment

<400>  79

Ile Leu Phe Gly Ile Ser Leu Arg Glu Val 
1               5                   10  


<210>  80
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide fragment

<400>  80

Lys Val Val Glu Phe Leu Ala Met Leu 
1               5                   


<210>  81
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide fragment

<400>  81

Met Leu Met Ala Gln Glu Ala Leu Ala Phe Leu 
1               5                   10      


<210>  82
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide fragment

<400>  82

Lys Ala Ser Glu Lys Ile Phe Tyr Val 
1               5                   


<210>  83
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide fragment

<400>  83

Arg Gln Lys Lys Ile Arg Ile Gln Leu 
1               5                   


<210>  84
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide fragment

<400>  84

Ile Met Ile Gly Val Leu Val Gly Val 
1               5                   


<210>  85
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide fragment

<400>  85

Lys Thr Trp Gly Gln Tyr Trp Gln Val 
1               5                   


<210>  86
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide fragment

<400>  86

Ala Met Leu Gly Thr His Thr Met Glu Val 
1               5                   10  


<210>  87
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide fragment

<400>  87

Met Leu Gly Thr His Thr Met Glu Val 
1               5                   


<210>  88
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide fragment

<400>  88

Ile Thr Asp Gln Val Pro Phe Ser Val 
1               5                   


<210>  89
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide fragment

<400>  89

Tyr Leu Glu Pro Gly Pro Val Thr Ala 
1               5                   


<210>  90
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide fragment

<400>  90

Leu Leu Asp Gly Thr Ala Thr Leu Arg Leu 
1               5                   10  


<210>  91
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide fragment

<400>  91

Val Leu Tyr Arg Tyr Gly Ser Phe Ser Val 
1               5                   10  


<210>  92
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide fragment

<400>  92

Ser Leu Ala Asp Thr Asn Ser Leu Ala Val 
1               5                   10  


<210>  93
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide fragment

<400>  93

Arg Leu Met Lys Gln Asp Phe Ser Val 
1               5                   


<210>  94
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide fragment

<400>  94

Arg Leu Pro Arg Ile Phe Cys Ser Cys 
1               5                   


<210>  95
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide fragment

<400>  95

Ser Leu Ser Lys Ile Leu Asp Thr Val 
1               5                   


<210>  96
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide fragment

<400>  96

Ser Val Tyr Asp Phe Phe Val Trp Leu 
1               5                   


<210>  97
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide fragment

<400>  97

Thr Leu Asp Ser Gln Val Met Ser Leu 
1               5                   


<210>  98
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide fragment

<400>  98

Met Leu Leu Ala Val Leu Tyr Cys Leu 
1               5                   


<210>  99
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide fragment

<400>  99

Cys Leu Leu Trp Ser Phe Gln Thr Ser Ala 
1               5                   10  


<210>  100
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide fragment

<400>  100

Tyr Met Asp Gly Thr Met Ser Gln Val 
1               5                   


<210>  101
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide fragment

<400>  101

Leu Leu Asn Ala Phe Thr Val Thr Val 
1               5                   


<210>  102
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide fragment

<400>  102

Lys Val His Pro Val Ile Trp Ser Leu 
1               5                   


<210>  103
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide fragment

<400>  103

Leu Met Leu Gln Asn Ala Leu Thr Thr Met 
1               5                   10  


<210>  104
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide fragment

<400>  104

Leu Leu Gly Ala Thr Cys Met Phe Val 
1               5                   


<210>  105
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide fragment

<400>  105

Ala Leu Leu Glu Ile Ala Ser Cys Leu 
1               5                   


<210>  106
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide fragment

<400>  106

Val Leu Phe Tyr Leu Gly Gln Tyr 
1               5               


<210>  107
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide fragment

<400>  107

Leu Leu Gly Arg Asn Ser Phe Glu Val 
1               5                   


<210>  108
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide fragment

<400>  108

Arg Met Pro Glu Ala Ala Pro Pro Val 
1               5                   


<210>  109
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide fragment

<400>  109

Val Leu Asp Gly Leu Asp Val Leu Leu 
1               5                   


<210>  110
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide fragment

<400>  110

Ser Leu Tyr Ser Phe Pro Glu Pro Glu Ala 
1               5                   10  


<210>  111
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide fragment

<400>  111

Ala Leu Tyr Val Asp Ser Leu Phe Phe Leu 
1               5                   10  


<210>  112
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide fragment

<400>  112

Ser Leu Leu Gln His Leu Ile Gly Leu 
1               5                   


<210>  113
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide fragment

<400>  113

Ala Trp Ile Ser Lys Pro Pro Gly Val 
1               5                   


<210>  114
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide fragment

<400>  114

Ser Ala Trp Ile Ser Lys Pro Pro Gly Val 
1               5                   10  


<210>  115
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide fragment

<400>  115

Glu Leu Thr Leu Gly Glu Phe Leu Lys Leu 
1               5                   10  


<210>  116
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide fragment

<400>  116

Arg Leu Val Asp Asp Phe Leu Leu Val 
1               5                   


<210>  117
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide fragment

<400>  117

Ala Ala Gly Ile Gly Ile Leu Thr Val 
1               5                   


<210>  118
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide fragment

<400>  118

Glu Leu Ala Gly Ile Gly Ile Leu Thr Val 
1               5                   10  


<210>  119
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide fragment

<400>  119

Ser Leu Leu Met Trp Ile Thr Gln Cys 
1               5                   


<210>  120
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide fragment

<400>  120

Ser Leu Leu Met Trp Ile Thr Gln Val 
1               5                   


<210>  121
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide fragment

<400>  121

Ile Leu Lys Glu Pro Val His Gly Val 
1               5                   


<210>  122
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide fragment

<400>  122

Leu Leu Phe Gly Tyr Pro Val Tyr Val 
1               5                   


