                         SEQUENCE LISTING

<110>  ACCELERON PHARMA INC. AND ADIMAB, LLC
       KNOPF, JOHN
       BELK, JONATHAN
       SHARKEY, NATHAN J.
       KUMAR, RAVINDRA
       GRINBERG, ASYA
       SAKO, DIANNE
       CASTONGUAY, ROSELYNE
       DAGON, YOSSI
 
<120>  ALK7 BINDING PROTEINS AND USES THEREOF

<130>  3174.004PC01/KKH

<150>  US 62/326,313
<151>  2016-04-22

<160>  189   

<170>  PatentIn version 3.5

<210>  1
<211>  5
<212>  PRT
<213>  homo sapiens

<400>  1

Ser Tyr Ala Ile Ser 
1               5   


<210>  2
<211>  17
<212>  PRT
<213>  homo sapiens

<400>  2

Gly Ile Ile Pro Ile Phe Gly Thr Ala Ser Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  3
<211>  12
<212>  PRT
<213>  homo sapiens

<400>  3

Thr Pro Tyr Tyr Asp Ser Ser Gly Tyr Leu Asp Val 
1               5                   10          


<210>  4
<211>  121
<212>  PRT
<213>  homo sapiens

<400>  4

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Ser Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Thr Pro Tyr Tyr Asp Ser Ser Gly Tyr Leu Asp Val Trp Gly 
            100                 105                 110         


Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120     


<210>  5
<211>  363
<212>  DNA
<213>  homo sapiens

<400>  5
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cttctggagg caccttcagc agctatgcta tcagctgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggaggg atcatcccta tctttggtac agcaagctac      180

gcacagaagt tccagggcag agtcacgatt accgcggacg aatccacgag cacagcctac      240

atggagctga gcagcctgag atctgaggac acggcggtgt actactgcgc cagaactcct      300

tactacgaca gcagcggata cctagacgta tggggtcagg gtacaatggt caccgtctcc      360

tca                                                                    363


<210>  6
<211>  30
<212>  PRT
<213>  homo sapiens

<400>  6

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser 
            20                  25                  30  


<210>  7
<211>  14
<212>  PRT
<213>  homo sapiens

<400>  7

Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly 
1               5                   10                  


<210>  8
<211>  32
<212>  PRT
<213>  homo sapiens

<400>  8

Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr Met Glu 
1               5                   10                  15      


Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  9
<211>  11
<212>  PRT
<213>  homo sapiens

<400>  9

Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
1               5                   10      


<210>  10
<211>  11
<212>  PRT
<213>  homo sapiens

<400>  10

Gln Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn 
1               5                   10      


<210>  11
<211>  7
<212>  PRT
<213>  homo sapiens

<400>  11

Asp Ala Ser Asn Leu Ala Thr 
1               5           


<210>  12
<211>  9
<212>  PRT
<213>  homo sapiens

<400>  12

Gln Gln Ser Leu Asp Leu Pro Pro Thr 
1               5                   


<210>  13
<211>  107
<212>  PRT
<213>  homo sapiens

<400>  13

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Leu Ala Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Ser Leu Asp Leu Pro Pro 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  14
<211>  321
<212>  DNA
<213>  homo sapiens

<400>  14
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc aggcgagtca ggacattagc aactatttaa attggtatca gcagaaacca      120

gggaaagccc ctaagctcct gatctacgat gcatccaatt tggcaacagg ggtcccatca      180

aggttcagtg gaagtggatc tgggacagat tttactttca ccatcagcag cctgcagcct      240

gaagatattg caacatatta ctgtcagcag tccctcgacc tccctcctac ttttggcgga      300

gggaccaagg ttgagatcaa a                                                321


<210>  15
<211>  23
<212>  PRT
<213>  homo sapiens

<400>  15

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys 
            20              


<210>  16
<211>  15
<212>  PRT
<213>  homo sapiens

<400>  16

Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  17
<211>  32
<212>  PRT
<213>  homo sapiens

<400>  17

Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
1               5                   10                  15      


Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys 
            20                  25                  30          


<210>  18
<211>  10
<212>  PRT
<213>  homo sapiens

<400>  18

Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
1               5                   10  


<210>  19
<211>  7
<212>  PRT
<213>  homo sapiens

<400>  19

Ser Ser Ser Tyr Tyr Trp Gly 
1               5           


<210>  20
<211>  16
<212>  PRT
<213>  homo sapiens

<400>  20

Asn Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  21
<211>  17
<212>  PRT
<213>  homo sapiens

<400>  21

Asp Gly Arg Tyr Gln Ser Ala Thr Ala Asp Tyr Tyr Tyr Gly Met Asp 
1               5                   10                  15      


Val 
    


<210>  22
<211>  127
<212>  PRT
<213>  homo sapiens

<400>  22

Gln Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Ser 
            20                  25                  30          


Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Asn Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Asp Gly Arg Tyr Gln Ser Ala Thr Ala Asp Tyr Tyr Tyr 
            100                 105                 110         


Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125         


<210>  23
<211>  381
<212>  DNA
<213>  homo sapiens

<400>  23
cagctgcagc tgcaggagtc gggcccagga ctggtgaagc cttcggagac cctgtccctc       60

acctgcactg tctctggtgg ctccatcagc agtagtagtt actactgggg ctggatccgc      120

cagcccccag ggaaggggct ggagtggatt gggaacatct attatagtgg gagcacctac      180

tacaacccgt ccctcaagag tcgagtcacc atatccgtag acacgtccaa gaaccagttc      240

tccctgaagc tgagttctgt gaccgccgca gacacggcgg tgtactactg cgccagagac      300

ggcagatacc aaagcgccac agccgattac tattacggta tggatgtctg gggccaggga      360

acaactgtca ccgtctcctc a                                                381


<210>  24
<211>  30
<212>  PRT
<213>  homo sapiens

<400>  24

Gln Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser 
            20                  25                  30  


<210>  25
<211>  14
<212>  PRT
<213>  homo sapiens

<400>  25

Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile Gly 
1               5                   10                  


<210>  26
<211>  32
<212>  PRT
<213>  homo sapiens

<400>  26

Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  27
<211>  11
<212>  PRT
<213>  homo sapiens

<400>  27

Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
1               5                   10      


<210>  28
<211>  12
<212>  PRT
<213>  homo sapiens

<400>  28

Arg Ala Ser Gln Ser Val Ser Ser Ser Tyr Leu Ala 
1               5                   10          


<210>  29
<211>  7
<212>  PRT
<213>  homo sapiens

<400>  29

Gly Ala Ser Ser Arg Ala Thr 
1               5           


<210>  30
<211>  9
<212>  PRT
<213>  homo sapiens

<400>  30

Gln Gln Val Phe Ser Tyr Pro Phe Thr 
1               5                   


<210>  31
<211>  108
<212>  PRT
<213>  homo sapiens

<400>  31

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Val Phe Ser Tyr Pro 
                85                  90                  95      


Phe Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  32
<211>  324
<212>  DNA
<213>  homo sapiens

<400>  32
gaaattgtgt tgacgcagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc       60

ctctcctgca gggccagtca gagtgttagc agcagctact tagcctggta ccagcagaaa      120

cctggccagg ctcccaggct cctcatctat ggtgcatcca gcagggccac tggcatccca      180

gacaggttca gtggcagtgg gtctgggaca gacttcactc tcaccatcag cagactggag      240

cctgaagatt ttgcagtgta ttactgtcag caggtcttca gttacccttt cacttttggc      300

ggagggacca aggttgagat caaa                                             324


<210>  33
<211>  23
<212>  PRT
<213>  homo sapiens

<400>  33

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys 
            20              


<210>  34
<211>  15
<212>  PRT
<213>  homo sapiens

<400>  34

Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  35
<211>  32
<212>  PRT
<213>  homo sapiens

<400>  35

Gly Ile Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
1               5                   10                  15      


Leu Thr Ile Ser Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys 
            20                  25                  30          


<210>  36
<211>  10
<212>  PRT
<213>  homo sapiens

<400>  36

Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
1               5                   10  


<210>  37
<211>  5
<212>  PRT
<213>  homo sapiens

<400>  37

Ser Tyr Ala Met Ser 
1               5   


<210>  38
<211>  17
<212>  PRT
<213>  homo sapiens

<400>  38

Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  39
<211>  9
<212>  PRT
<213>  homo sapiens

<400>  39

Arg Tyr Arg Gly Val Ser Phe Asp Ile 
1               5                   


<210>  40
<211>  118
<212>  PRT
<213>  homo sapiens

<400>  40

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Tyr Arg Gly Val Ser Phe Asp Ile Trp Gly Arg Gly Thr 
            100                 105                 110         


Met Val Thr Val Ser Ser 
        115             


<210>  41
<211>  354
<212>  DNA
<213>  homo sapiens

<400>  41
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttagc agctatgcca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcagct attagtggta gtggtggtag cacatactac      180

gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcaaatga acagcctgag agccgaggac acggcggtgt actactgcgc caggagatac      300

agaggagtgt cattcgacat atggggtcgg ggtacaatgg tcaccgtctc ctca            354


<210>  42
<211>  30
<212>  PRT
<213>  homo sapiens

<400>  42

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser 
            20                  25                  30  


<210>  43
<211>  14
<212>  PRT
<213>  homo sapiens

<400>  43

Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser 
1               5                   10                  


<210>  44
<211>  32
<212>  PRT
<213>  homo sapiens

<400>  44

Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
1               5                   10                  15      


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  45
<211>  11
<212>  PRT
<213>  homo sapiens

<400>  45

Trp Gly Arg Gly Thr Met Val Thr Val Ser Ser 
1               5                   10      


<210>  46
<211>  12
<212>  PRT
<213>  homo sapiens

<400>  46

Arg Ala Ser Gln Ser Val Ser Ser Ser Tyr Leu Ala 
1               5                   10          


<210>  47
<211>  7
<212>  PRT
<213>  homo sapiens

<400>  47

Gly Ala Ser Ser Arg Ala Thr 
1               5           


<210>  48
<211>  8
<212>  PRT
<213>  homo sapiens

<400>  48

Gln Gln Asp Ser Ile Asp Ile Thr 
1               5               


<210>  49
<211>  107
<212>  PRT
<213>  homo sapiens

<400>  49

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Asp Ser Ile Asp Ile 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  50
<211>  321
<212>  DNA
<213>  homo sapiens

<400>  50
gaaattgtgt tgacgcagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc       60

ctctcctgca gggccagtca gagtgttagc agcagctact tagcctggta ccagcagaaa      120

cctggccagg ctcccaggct cctcatctat ggtgcatcca gcagggccac tggcatccca      180

gacaggttca gtggcagtgg gtctgggaca gacttcactc tcaccatcag cagactggag      240

cctgaagatt ttgcagtgta ttactgtcag caggactcca tcgacatcac ttttggcgga      300

gggaccaagg ttgagatcaa a                                                321


<210>  51
<211>  23
<212>  PRT
<213>  homo sapiens

<400>  51

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys 
            20              


<210>  52
<211>  15
<212>  PRT
<213>  homo sapiens

<400>  52

Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  53
<211>  32
<212>  PRT
<213>  homo sapiens

<400>  53

Gly Ile Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
1               5                   10                  15      


Leu Thr Ile Ser Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys 
            20                  25                  30          


<210>  54
<211>  10
<212>  PRT
<213>  homo sapiens

<400>  54

Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
1               5                   10  


<210>  55
<211>  5
<212>  PRT
<213>  homo sapiens

<400>  55

Ser Tyr Ala Met Ser 
1               5   


<210>  56
<211>  17
<212>  PRT
<213>  homo sapiens

<400>  56

Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  57
<211>  9
<212>  PRT
<213>  homo sapiens

<400>  57

Pro Tyr Gln Ala Arg Ala Phe Asp Ile 
1               5                   


<210>  58
<211>  118
<212>  PRT
<213>  homo sapiens

<400>  58

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Pro Tyr Gln Ala Arg Ala Phe Asp Ile Trp Gly Gln Gly Thr 
            100                 105                 110         


Met Val Thr Val Ser Ser 
        115             


<210>  59
<211>  354
<212>  DNA
<213>  homo sapiens

<400>  59
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttagc agctatgcca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcagct attagtggta gtggtggtag cacatactac      180

gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcaaatga acagcctgag agccgaggac acggcggtgt actactgcgc cagaccttac      300

caagccagag cctttgatat ttggggtcag ggtacaatgg tcaccgtctc ctca            354


<210>  60
<211>  30
<212>  PRT
<213>  homo sapiens

<400>  60

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser 
            20                  25                  30  


<210>  61
<211>  14
<212>  PRT
<213>  homo sapiens

<400>  61

Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser 
1               5                   10                  


<210>  62
<211>  32
<212>  PRT
<213>  homo sapiens

<400>  62

Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
1               5                   10                  15      


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  63
<211>  11
<212>  PRT
<213>  homo sapiens

<400>  63

Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
1               5                   10      


<210>  64
<211>  12
<212>  PRT
<213>  homo sapiens

<400>  64

Arg Ala Ser Gln Ser Val Ser Ser Ser Phe Leu Ala 
1               5                   10          


<210>  65
<211>  7
<212>  PRT
<213>  homo sapiens

<400>  65

Gly Ala Ser Ser Arg Ala Thr 
1               5           


<210>  66
<211>  9
<212>  PRT
<213>  homo sapiens

<400>  66

Gln Gln Tyr Val Val Ala Pro Ile Thr 
1               5                   


<210>  67
<211>  108
<212>  PRT
<213>  homo sapiens

<400>  67

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          


Phe Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Val Val Ala Pro 
                85                  90                  95      


Ile Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  68
<211>  324
<212>  DNA
<213>  homo sapiens

<400>  68
gaaattgtgt tgacgcagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc       60

ctctcctgca gggccagtca gagtgttagc agcagcttct tagcctggta ccagcagaaa      120

cctggccagg ctcccaggct cctcatctat ggtgcatcca gcagggccac tggcatccca      180

gacaggttca gtggcagtgg gtctgggaca gacttcactc tcaccatcag cagactggag      240

cctgaagatt ttgcagtgta ttactgtcag cagtacgtcg tcgcccctat cacttttggc      300

ggagggacca aggttgagat caaa                                             324


<210>  69
<211>  23
<212>  PRT
<213>  homo sapiens

<400>  69

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys 
            20              


<210>  70
<211>  15
<212>  PRT
<213>  homo sapiens

<400>  70

Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  71
<211>  32
<212>  PRT
<213>  homo sapiens

<400>  71

Gly Ile Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
1               5                   10                  15      


Leu Thr Ile Ser Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys 
            20                  25                  30          


<210>  72
<211>  10
<212>  PRT
<213>  homo sapiens

<400>  72

Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
1               5                   10  


<210>  73
<211>  9
<212>  PRT
<213>  homo sapiens

<400>  73

Gly Thr Phe Ser Ser Tyr Ala Ile Ser 
1               5                   


<210>  74
<211>  17
<212>  PRT
<213>  homo sapiens

<400>  74

Gly Ile Ile Pro Ile Phe Gly Thr Ala Ser Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  75
<211>  14
<212>  PRT
<213>  homo sapiens

<400>  75

Ala Arg Thr Pro Tyr Tyr Asp Ser Ser Gly Tyr Leu Asp Val 
1               5                   10                  


<210>  76
<211>  11
<212>  PRT
<213>  homo sapiens

<400>  76

Gly Ser Ile Ser Ser Ser Ser Tyr Tyr Trp Gly 
1               5                   10      


<210>  77
<211>  16
<212>  PRT
<213>  homo sapiens

<400>  77

Asn Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  78
<211>  19
<212>  PRT
<213>  homo sapiens

<400>  78

Ala Arg Asp Gly Arg Tyr Gln Ser Ala Thr Ala Asp Tyr Tyr Tyr Gly 
1               5                   10                  15      


Met Asp Val 
            


<210>  79
<211>  9
<212>  PRT
<213>  homo sapiens

<400>  79

Phe Thr Phe Ser Ser Tyr Ala Met Ser 
1               5                   


<210>  80
<211>  17
<212>  PRT
<213>  homo sapiens

<400>  80

Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  81
<211>  11
<212>  PRT
<213>  homo sapiens

<400>  81

Ala Arg Arg Tyr Arg Gly Val Ser Phe Asp Ile 
1               5                   10      


<210>  82
<211>  9
<212>  PRT
<213>  homo sapiens

<400>  82

Phe Thr Phe Ser Ser Tyr Ala Met Ser 
1               5                   


<210>  83
<211>  17
<212>  PRT
<213>  homo sapiens

<400>  83

Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  84
<211>  11
<212>  PRT
<213>  homo sapiens

<400>  84

Ala Arg Pro Tyr Gln Ala Arg Ala Phe Asp Ile 
1               5                   10      


<210>  85
<211>  493
<212>  PRT
<213>  homo sapiens

<400>  85

Met Thr Arg Ala Leu Cys Ser Ala Leu Arg Gln Ala Leu Leu Leu Leu 
1               5                   10                  15      


Ala Ala Ala Ala Glu Leu Ser Pro Gly Leu Lys Cys Val Cys Leu Leu 
            20                  25                  30          


Cys Asp Ser Ser Asn Phe Thr Cys Gln Thr Glu Gly Ala Cys Trp Ala 
        35                  40                  45              


Ser Val Met Leu Thr Asn Gly Lys Glu Gln Val Ile Lys Ser Cys Val 
    50                  55                  60                  


Ser Leu Pro Glu Leu Asn Ala Gln Val Phe Cys His Ser Ser Asn Asn 
65                  70                  75                  80  


Val Thr Lys Thr Glu Cys Cys Phe Thr Asp Phe Cys Asn Asn Ile Thr 
                85                  90                  95      


Leu His Leu Pro Thr Ala Ser Pro Asn Ala Pro Lys Leu Gly Pro Met 
            100                 105                 110         


Glu Leu Ala Ile Ile Ile Thr Val Pro Val Cys Leu Leu Ser Ile Ala 
        115                 120                 125             


Ala Met Leu Thr Val Trp Ala Cys Gln Gly Arg Gln Cys Ser Tyr Arg 
    130                 135                 140                 


Lys Lys Lys Arg Pro Asn Val Glu Glu Pro Leu Ser Glu Cys Asn Leu 
145                 150                 155                 160 


Val Asn Ala Gly Lys Thr Leu Lys Asp Leu Ile Tyr Asp Val Thr Ala 
                165                 170                 175     


Ser Gly Ser Gly Ser Gly Leu Pro Leu Leu Val Gln Arg Thr Ile Ala 
            180                 185                 190         


Arg Thr Ile Val Leu Gln Glu Ile Val Gly Lys Gly Arg Phe Gly Glu 
        195                 200                 205             


Val Trp His Gly Arg Trp Cys Gly Glu Asp Val Ala Val Lys Ile Phe 
    210                 215                 220                 


Ser Ser Arg Asp Glu Arg Ser Trp Phe Arg Glu Ala Glu Ile Tyr Gln 
225                 230                 235                 240 


Thr Val Met Leu Arg His Glu Asn Ile Leu Gly Phe Ile Ala Ala Asp 
                245                 250                 255     


Asn Lys Asp Asn Gly Thr Trp Thr Gln Leu Trp Leu Val Ser Glu Tyr 
            260                 265                 270         


His Glu Gln Gly Ser Leu Tyr Asp Tyr Leu Asn Arg Asn Ile Val Thr 
        275                 280                 285             


Val Ala Gly Met Ile Lys Leu Ala Leu Ser Ile Ala Ser Gly Leu Ala 
    290                 295                 300                 


His Leu His Met Glu Ile Val Gly Thr Gln Gly Lys Pro Ala Ile Ala 
305                 310                 315                 320 


His Arg Asp Ile Lys Ser Lys Asn Ile Leu Val Lys Lys Cys Glu Thr 
                325                 330                 335     


Cys Ala Ile Ala Asp Leu Gly Leu Ala Val Lys His Asp Ser Ile Leu 
            340                 345                 350         


Asn Thr Ile Asp Ile Pro Gln Asn Pro Lys Val Gly Thr Lys Arg Tyr 
        355                 360                 365             


Met Ala Pro Glu Met Leu Asp Asp Thr Met Asn Val Asn Ile Phe Glu 
    370                 375                 380                 


Ser Phe Lys Arg Ala Asp Ile Tyr Ser Val Gly Leu Val Tyr Trp Glu 
385                 390                 395                 400 


Ile Ala Arg Arg Cys Ser Val Gly Gly Ile Val Glu Glu Tyr Gln Leu 
                405                 410                 415     


Pro Tyr Tyr Asp Met Val Pro Ser Asp Pro Ser Ile Glu Glu Met Arg 
            420                 425                 430         


Lys Val Val Cys Asp Gln Lys Phe Arg Pro Ser Ile Pro Asn Gln Trp 
        435                 440                 445             


Gln Ser Cys Glu Ala Leu Arg Val Met Gly Arg Ile Met Arg Glu Cys 
    450                 455                 460                 


Trp Tyr Ala Asn Gly Ala Ala Arg Leu Thr Ala Leu Arg Ile Lys Lys 
465                 470                 475                 480 


Thr Ile Ser Gln Leu Cys Val Lys Glu Asp Cys Lys Ala 
                485                 490             


<210>  86
<211>  88
<212>  PRT
<213>  homo sapiens

<400>  86

Leu Lys Cys Val Cys Leu Leu Cys Asp Ser Ser Asn Phe Thr Cys Gln 
1               5                   10                  15      


Thr Glu Gly Ala Cys Trp Ala Ser Val Met Leu Thr Asn Gly Lys Glu 
            20                  25                  30          


Gln Val Ile Lys Ser Cys Val Ser Leu Pro Glu Leu Asn Ala Gln Val 
        35                  40                  45              


Phe Cys His Ser Ser Asn Asn Val Thr Lys Thr Glu Cys Cys Phe Thr 
    50                  55                  60                  


Asp Phe Cys Asn Asn Ile Thr Leu His Leu Pro Thr Ala Ser Pro Asn 
65                  70                  75                  80  


Ala Pro Lys Leu Gly Pro Met Glu 
                85              


<210>  87
<211>  88
<212>  PRT
<213>  rat

<400>  87

Leu Lys Cys Val Cys Leu Leu Cys Asp Ser Ser Asn Phe Thr Cys Gln 
1               5                   10                  15      


Thr Glu Gly Ala Cys Trp Ala Ser Val Met Leu Thr Asn Gly Lys Glu 
            20                  25                  30          


Gln Val Ser Lys Ser Cys Val Ser Leu Pro Glu Leu Asn Ala Gln Val 
        35                  40                  45              


Phe Cys His Ser Ser Asn Asn Val Thr Lys Thr Glu Cys Cys Phe Thr 
    50                  55                  60                  


Asp Phe Cys Asn Asn Ile Thr Gln His Leu Pro Thr Ala Ser Pro Asp 
65                  70                  75                  80  


Ala Pro Arg Leu Gly Pro Thr Glu 
                85              


<210>  88
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH CDR1

<400>  88

Val Tyr Ala Met Ser 
1               5   


<210>  89
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH CDR2

<400>  89

Ala Ile Ser Gly Ser Gly Asp Ser Thr Val Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  90
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH CDR3

<400>  90

Pro Ser Tyr Gln Pro Ile Tyr 
1               5           


<210>  91
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Protein

<400>  91

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Val Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Asp Ser Thr Val Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Pro Ser Tyr Gln Pro Ile Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  92
<211>  348
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VH DNA

<400>  92
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt caccttttcg gtgtatgcca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcagct attagtggaa gtggtgatag cacagtgtac      180

gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcaaatga acagcctgag agccgaggac acggcggtgt actactgcgc caagccttct      300

taccaaccaa tatactgggg acagggtaca ttggtcaccg tctcctca                   348


<210>  93
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH FR3

<400>  93

Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
1               5                   10                  15      


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys 
            20                  25                  30          


<210>  94
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH FR4

<400>  94

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  95
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL CDR1

<400>  95

Arg Ala Ser Gln Gly Ile Ser Ser Trp Leu Ala 
1               5                   10      


<210>  96
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL CDR2

<400>  96

Ala Ala Ser Ser Leu Gln Ser 
1               5           


<210>  97
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL CDR3

<400>  97

Gln Gln Ala Ala Ser Tyr Pro Leu Thr 
1               5                   


<210>  98
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Protein

<400>  98

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala Ala Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  99
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VL DNA

<400>  99
gacatccaga tgacccaaag ccctagttcc gtctctgcaa gcgtgggaga tagggtcaca       60

atcacatgta gagcttctca ggggatctct agctggctgg cttggtatca gcagaagccc      120

ggtaaggccc caaagctctt gatatacgcc gcctcttctc ttcaatctgg ggtgccatcc      180

cgcttctcag ggagcggtag cgggaccgat ttcaccctca ctatcagcag cctgcagcct      240

gaagactttg ctacctacta ctgccagcaa gccgcttctt atcctctgac tttcggtggg      300

ggtactaaag tggagattaa a                                                321


<210>  100
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL FR1

<400>  100

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys 
            20              


<210>  101
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL FR3

<400>  101

Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
1               5                   10                  15      


Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 
            20                  25                  30          


<210>  102
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH CDR1

<400>  102

Ser Ser Ala Ile Gly 
1               5   


<210>  103
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH CDR2

<400>  103

Gly Ile Trp Pro Ile Phe Gly Thr Ala Leu Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  104
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH CDR3

<400>  104

Asp Pro Arg Glu Tyr Ile His Val Phe Asp Ile 
1               5                   10      


<210>  105
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Protein

<400>  105

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Ser 
            20                  25                  30          


Ala Ile Gly Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Trp Pro Ile Phe Gly Thr Ala Leu Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Pro Arg Glu Tyr Ile His Val Phe Asp Ile Trp Gly Gln 
            100                 105                 110         


Gly Thr Met Val Thr Val Ser Ser 
        115                 120 


<210>  106
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VH DNA

<400>  106
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cttctggagg caccttcagc agcagtgcta tcgggtgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggaggg atctggccta tctttggtac agcactttac      180

gcacagaagt tccagggcag agtcacgatt accgcggacg aatccacgag cacagcctac      240

atggagctga gcagcctgag atctgaggac acggcggtgt actactgcgc cagagatcca      300

agagaatata tccacgtatt cgacatatgg ggtcagggta caatggtcac cgtctcctca      360


<210>  107
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL CDR1

<400>  107

Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn 
1               5                   10      


<210>  108
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL CDR2

<400>  108

Gly Ala Ser Ser Leu Gln Ser 
1               5           


<210>  109
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL CDR3

<400>  109

Gln Gln Ala Tyr Ser Phe Pro Trp Thr 
1               5                   


<210>  110
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Protein

<400>  110

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala Tyr Ser Phe Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Ile Lys Val Glu Ile Lys 
            100                 105         


<210>  111
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VL DNA

<400>  111
gatattcaga tgacacagtc acctagcagt ctgagcgcat cagtgggtga tcgagtgaca       60

atcacttgta gagcttccca gtctattagc tcatacctga actggtatca gcaaaagcct      120

gggaaggctc ctaagctgtt gatctatgga gcatctagcc tgcagtccgg cgtgccatcc      180

cgcttcagcg ggagcggctc cgggaccgat tttaccctga caatctctag cctgcagcct      240

gaagattttg caacctacta ctgccagcag gcatacagct tcccctggac attcggaggt      300

ggcataaaag ttgaaatcaa a                                                321


<210>  112
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL FR3

<400>  112

Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
1               5                   10                  15      


Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 
            20                  25                  30          


<210>  113
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL FR4

<400>  113

Phe Gly Gly Gly Ile Lys Val Glu Ile Lys 
1               5                   10  


<210>  114
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH CDR1

<400>  114

Gly Gln Ala Ile Ser 
1               5   


<210>  115
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH CDR2

<400>  115

Gly Ile Ile Pro Ser Phe Gly Thr Ala Arg Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  116
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH CDR3

<400>  116

Thr Pro Tyr Tyr Asp Ser Ser Gly Tyr Leu Asp Val 
1               5                   10          


<210>  117
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Protein

<400>  117

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Gly Gln 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ser Phe Gly Thr Ala Arg Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Thr Pro Tyr Tyr Asp Ser Ser Gly Tyr Leu Asp Val Trp Gly 
            100                 105                 110         


Gln Gly Thr Met Val Thr Val Ser 
        115                 120 


<210>  118
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VH DNA

<400>  118
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cttctggagg caccttcagc ggtcaggcta tcagctgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggaggg atcatccctt cgtttggtac agcacggtac      180

gcacagaagt tccagggcag agtcacgatt accgcggacg aatccacgag cacagcctac      240

atggagctga gcagcctgag atctgaggac acggcggtgt actactgcgc cagaactcct      300

tactacgaca gcagcggata cctagacgta tggggtcagg gtacaatggt caccgtctcc      360

tca                                                                    363


<210>  119
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH FR3

<400>  119

Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr Met Glu 
1               5                   10                  15      


Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  120
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH FR4

<400>  120

Trp Gly Gln Gly Thr Met Val Thr Val Ser 
1               5                   10  


<210>  121
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL CDR1

<400>  121

Gln Ala Ser His Asp Ile Asp Asn Tyr Leu Asn 
1               5                   10      


<210>  122
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL CDR2

<400>  122

Tyr Ala Ser Asn Leu Lys Thr 
1               5           


<210>  123
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL CDR3

<400>  123

Gln Gln Ser Arg Ala Ser Pro Pro Thr 
1               5                   


<210>  124
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Protein

<400>  124

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser His Asp Ile Asp Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Ala Ser Asn Leu Lys Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Ser Arg Ala Ser Pro Pro 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  125
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH CDR1

<400>  125

Gly Gly Ser Ile Ser Ser Ser Ala Tyr 
1               5                   


<210>  126
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH CDR2

<400>  126

Ser Ile Tyr Leu Ser Gly Ser Thr Thr Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  127
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH CDR3

<400>  127

Asp Gly Arg Tyr Gln Ser Arg Ser Pro Asp Tyr Tyr Tyr Gly Met Asp 
1               5                   10                  15      


Val 
    


<210>  128
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Protein

<400>  128

Gln Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Ser 
            20                  25                  30          


Ala Tyr Tyr Trp Ala Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Ser Ile Tyr Leu Ser Gly Ser Thr Thr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Asp Gly Arg Tyr Gln Ser Arg Ser Pro Asp Tyr Tyr Tyr 
            100                 105                 110         


Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125         


<210>  129
<211>  381
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VH DNA

<400>  129
cagctgcagc tgcaggagtc gggcccagga ctggtgaagc cttcggagac cctgtccctc       60

acctgcactg tctctggtgg ctccatcagc agtagtgctt actactgggc gtggatccgc      120

cagcccccag ggaaggggct ggagtggatt gggagtatct atttgagtgg gagcaccact      180

tacaacccgt ccctcaagag tcgagtcacc atatccgtag acacgtccaa gaaccagttc      240

tccctgaagc tgagttctgt gaccgccgca gacacggcgg tgtactactg cgccagagac      300

ggcagatacc aaagcaggtc gccggattac tattacggta tggatgtctg gggccaggga      360

acaacggtca ccgtctcctc a                                                381


<210>  130
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH FR1

<400>  130

Gln Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser 
            20                  25  


<210>  131
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH FR2

<400>  131

Tyr Trp Ala Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
1               5                   10                  15      


Gly 
    


<210>  132
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL CDR1

<400>  132

Lys Ala Ser Gln Ser Val Ser Ser Ser Tyr Leu Ala 
1               5                   10          


<210>  133
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL CDR2

<400>  133

Gly Ala Phe Ser Arg Ala Asn 
1               5           


<210>  134
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL CDR3

<400>  134

Gln Gln Leu Val Ser Tyr Pro Phe Thr 
1               5                   


<210>  135
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Protein

<400>  135

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Lys Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Phe Ser Arg Ala Asn Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Leu Val Ser Tyr Pro 
                85                  90                  95      


Phe Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  136
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VL DNA

<400>  136
gagatagtct tgacccagtc accaggcacc cttagcttgt ctcccgggga acgcgccaca       60

ctcagctgta aagcctctca gtcagtttct agttcctacc tcgcttggta tcaacaaaag      120

cccggacaag caccaaggct gttgatctac ggagctttca gtcgcgcaaa tggcattccc      180

gaccgattct ctggcagtgg tagtggcacc gacttcactc tcacaatttc taggttggaa      240

cctgaggact ttgctgtgta ctactgtcaa caactggttt cttatccctt tacattcggt      300

ggcggcacaa aagtcgagat taaa                                             324


<210>  137
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH CDR1

<400>  137

Gly Tyr Asn Met His 
1               5   


<210>  138
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH CDR2

<400>  138

Asn Pro Asn Ser Gly Trp 
1               5       


<210>  139
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH CDR3

<400>  139

Asp Pro Val Gly Ala Arg Tyr Glu Val Phe Asp Tyr 
1               5                   10          


<210>  140
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Protein

<400>  140

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ala Gly Tyr 
            20                  25                  30          


Asn Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Ile Ile Asn Pro Asn Ser Gly Trp Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Val Ser Ala Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Pro Val Gly Ala Arg Tyr Glu Val Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  141
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VH DNA

<400>  141
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggata caccttcgct ggctacaata tgcactgggt gcgacaggcc      120

cctggacaag ggcttgagtg ggtgggaatt atcaacccta acagtggttg gacaaactat      180

gcacagaagt tccagggcag ggtcacgatg accagggaca cgtccgtcag cgcagcctac      240

atggagctga gcaggctgag atctgacgac acggcggtgt actactgcgc cagagaccct      300

gtcggagcaa gatacgaggt tttcgattac tggggacagg gtacattggt caccgtctcc      360

tca                                                                    363


<210>  142
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH FR1

<400>  142

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ala 
            20                  25                  30  


<210>  143
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH FR2

<400>  143

Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Val Gly Ile Ile 
1               5                   10                  15      


<210>  144
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH FR4

<400>  144

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  145
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL CDR1

<400>  145

Arg Ala Ser Gln Ser Val Ser Ser Ala Leu Ala 
1               5                   10      


<210>  146
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL CDR2

<400>  146

Ser Ala Phe Thr Arg Ala Ser 
1               5           


<210>  147
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL CDR3

<400>  147

Gln Gln Ala Trp Ala Phe Pro Leu Thr 
1               5                   


<210>  148
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Protein

<400>  148

Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ala 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Phe Thr Arg Ala Ser Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Ala Trp Ala Phe Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  149
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VL DNA

<400>  149
gaaatcgtga tgacccaatc acctgccact ctgtctgtta gccctgggga acgggccacc       60

ctcagttgta gggccagtca gagtgttagt tcagctttgg cttggtatca gcagaagccc      120

ggacaggccc caaggctgct gatctactct gctttcaccc gcgcaagcgg catccccgca      180

cgctttagcg gctccggaag cggcaccgag tttactctta ctatttcttc tttgcagagt      240

gaggattttg ccgtgtacta ctgccagcag gcctgggcat ttccactcac tttcgggggc      300

gggaccaagg tcgaaatcaa g                                                321


<210>  150
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VL DNA

<400>  150
gacatccaga tgacacagtc ccctagcagc ttgtcagcct cagtgggcga tagagtgacc       60

atcacctgtc aagccagcca tgatatagac aactatctca attggtacca gcagaaacca      120

ggcaaggcac caaagctcct gatctattac gcctcaaacc ttaagaccgg cgtcccaagc      180

cggttttcag gcagcggcag cgggacagat ttcaccttca caatttcatc actgcaacct      240

gaggatatag ccacttacta ttgtcagcag agcagagcca gcccccctac cttcggcggc      300

ggtaccaaag ttgaaatcaa g                                                321


<210>  151
<211>  348
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VH DNA

<400>  151
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttagc agctatgcca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcagct attagtggta gtggtggtag cacatactac      180

gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcaaatga acagcctgag agccgaggac acggcggtgt actactgcgc caagccttct      300

taccaaccaa tatactgggg acagggtaca ttggtcaccg tctcctca                   348


<210>  152
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Protein

<400>  152

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Pro Ser Tyr Gln Pro Ile Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  153
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH ABR1

<400>  153

Phe Thr Phe Ser Ser Tyr Ala Met Ser 
1               5                   


<210>  154
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH ABR2

<400>  154

Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  155
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH ABR3

<400>  155

Ala Lys Pro Ser Tyr Gln Pro Ile Tyr 
1               5                   


<210>  156
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH CDR1

<400>  156

Asn Tyr Ala Ile Ser 
1               5   


<210>  157
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH CDR2

<400>  157

Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  158
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VH DNA

<400>  158
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cttctggagg caccttcagc aactatgcta tcagctgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggaggg atcatcccta tctttggtac agcaaactac      180

gcacagaagt tccagggcag agtcacgatt accgcggacg aatccacgag cacagcctac      240

atggagctga gcagcctgag atctgaggac acggcggtgt actactgcgc cagagatcca      300

agagaatata tccacgtatt cgacatatgg ggtcagggta caatggtcac cgtctcctca      360


<210>  159
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Protein

<400>  159

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Asn Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Pro Arg Glu Tyr Ile His Val Phe Asp Ile Trp Gly Gln 
            100                 105                 110         


Gly Thr Met Val Thr Val Ser Ser 
        115                 120 


<210>  160
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH ABR1

<400>  160

Gly Thr Phe Ser Asn Tyr Ala Ile Ser 
1               5                   


<210>  161
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH ABR2

<400>  161

Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  162
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH ABR3

<400>  162

Ala Arg Asp Pro Arg Glu Tyr Ile His Val Phe Asp Ile 
1               5                   10              


<210>  163
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH CDR2

<400>  163

Ser Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  164
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH CDR3

<400>  164

Asp Pro Val Gly Ala Arg Tyr Glu Val Phe Asp Tyr 
1               5                   10          


<210>  165
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VH DNA

<400>  165
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cttctggagg caccttcagc agctatgcta tcagctgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggaagc atcatcccta tctttggtac agcaaactac      180

gcacagaagt tccagggcag agtcacgatt accgcggacg aatccacgag cacagcctac      240

atggagctga gcagcctgag atctgaggac acggcggtgt actactgcgc cagagaccct      300

gtcggagcaa gatacgaggt tttcgattac tggggacagg gtacattggt caccgtctcc      360

tca                                                                    363


<210>  166
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Protein

<400>  166

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ser Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Pro Val Gly Ala Arg Tyr Glu Val Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  167
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL CDR1

<400>  167

Arg Ala Ser Gln Ser Val Ser Ser Asn Leu Ala 
1               5                   10      


<210>  168
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL CDR2

<400>  168

Ser Ala Ser Thr Arg Ala Thr 
1               5           


<210>  169
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL CDR3

<400>  169

Gln Gln Ala Asn Thr Phe Pro Leu Thr 
1               5                   


<210>  170
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VL DNA

<400>  170
gaaatagtga tgacgcagtc tccagccacc ctgtctgtgt ctccagggga aagagccacc       60

ctctcctgca gggccagtca gagtgttagc agcaacttag cctggtacca gcagaaacct      120

ggccaggctc ccaggctcct catctatagc gcatccacca gggccactgg tatcccagcc      180

aggttcagtg gcagtgggtc tgggacagag ttcactctca ccatcagcag cctgcagtct      240

gaagattttg cagtttatta ctgtcagcag gccaatacct tccctctcac ttttggcgga      300

gggaccaagg ttgagatcaa a                                                321


<210>  171
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Protein

<400>  171

Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Thr Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Ala Asn Thr Phe Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  172
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH ABR1

<400>  172

Gly Thr Phe Ser Ser Tyr Ala Ile Ser 
1               5                   


<210>  173
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH ABR2

<400>  173

Ser Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  174
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH ABR3

<400>  174

Ala Arg Asp Pro Val Gly Ala Arg Tyr Glu Val Phe Asp Tyr 
1               5                   10                  


<210>  175
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH ABR1

<400>  175

Phe Thr Phe Ser Val Tyr Ala Met Ser 
1               5                   


<210>  176
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH ABR2

<400>  176

Ala Ile Ser Gly Ser Gly Asp Ser Thr Val Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  177
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH ABR3

<400>  177

Ala Lys Pro Ser Tyr Gln Pro Ile Tyr 
1               5                   


<210>  178
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH ABR1

<400>  178

Gly Thr Phe Ser Ser Ser Ala Ile Gly 
1               5                   


<210>  179
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH ABR2

<400>  179

Gly Ile Trp Pro Ile Phe Gly Thr Ala Leu Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  180
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH ABR3

<400>  180

Ala Arg Asp Pro Arg Glu Tyr Ile His Val Phe Asp Ile 
1               5                   10              


<210>  181
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH ABR1

<400>  181

Gly Thr Phe Ser Gly Gln Ala Ile Ser 
1               5                   


<210>  182
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH ABR2

<400>  182

Gly Ile Ile Pro Ser Phe Gly Thr Ala Arg Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  183
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH ABR3

<400>  183

Ala Arg Thr Pro Tyr Tyr Asp Ser Ser Gly Tyr Leu Asp Val 
1               5                   10                  


<210>  184
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH ABR1

<400>  184

Gly Ser Ile Ser Ser Ser Ala Tyr Tyr Trp Ala 
1               5                   10      


<210>  185
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH ABR2

<400>  185

Ser Ile Tyr Leu Ser Gly Ser Thr Thr Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  186
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH ABR3

<400>  186

Ala Arg Asp Gly Arg Tyr Gln Ser Ala Thr Ala Asp Tyr Tyr Tyr Gly 
1               5                   10                  15      


Met Asp Val 
            


<210>  187
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH ABR1

<400>  187

Tyr Thr Phe Ala Gly Tyr Asn Met His 
1               5                   


<210>  188
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH ABR2

<400>  188

Ile Ile Asn Pro Asn Ser Gly Trp Thr Asn Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  189
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH ABR3

<400>  189

Ala Arg Asp Pro Val Gly Ala Arg Tyr Glu Val Phe Asp Tyr 
1               5                   10                  


