                         SEQUENCE LISTING

<110>  University of Vermont and State Agricultural College
       Buskiewicz, Iwona
       Koenig, Andreas
 
<120>  MITOCHONDIAL ANTIVIRAL-SIGNALING (MAVS) POLYPEPTIDES AND 
       DETECTION AND USE THEREOF

<130>  UVM70124WO

<150>  US 62/325618
<151>  2016-04-21

<160>  23    

<170>  PatentIn version 3.5

<210>  1
<211>  540
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Pro Phe Ala Glu Asp Lys Thr Tyr Lys Tyr Ile Cys Arg Asn Phe 
1               5                   10                  15      


Ser Asn Phe Cys Asn Val Asp Val Val Glu Ile Leu Pro Tyr Leu Pro 
            20                  25                  30          


Cys Leu Thr Ala Arg Asp Gln Asp Arg Leu Arg Ala Thr Cys Thr Leu 
        35                  40                  45              


Ser Gly Asn Arg Asp Thr Leu Trp His Leu Phe Asn Thr Leu Gln Arg 
    50                  55                  60                  


Arg Pro Gly Trp Val Glu Tyr Phe Ile Ala Ala Leu Arg Gly Cys Glu 
65                  70                  75                  80  


Leu Val Asp Leu Ala Asp Glu Val Ala Ser Val Tyr Gln Ser Tyr Gln 
                85                  90                  95      


Pro Arg Thr Ser Asp Arg Pro Pro Asp Pro Leu Glu Pro Pro Ser Leu 
            100                 105                 110         


Pro Ala Glu Arg Pro Gly Pro Pro Thr Pro Ala Ala Ala His Ser Ile 
        115                 120                 125             


Pro Tyr Asn Ser Cys Arg Glu Lys Glu Pro Ser Tyr Pro Met Pro Val 
    130                 135                 140                 


Gln Glu Thr Gln Ala Pro Glu Ser Pro Gly Glu Asn Ser Glu Gln Ala 
145                 150                 155                 160 


Leu Gln Thr Leu Ser Pro Arg Ala Ile Pro Arg Asn Pro Asp Gly Gly 
                165                 170                 175     


Pro Leu Glu Ser Ser Ser Asp Leu Ala Ala Leu Ser Pro Leu Thr Ser 
            180                 185                 190         


Ser Gly His Gln Glu Gln Asp Thr Glu Leu Gly Ser Thr His Thr Ala 
        195                 200                 205             


Gly Ala Thr Ser Ser Leu Thr Pro Ser Arg Gly Pro Val Ser Pro Ser 
    210                 215                 220                 


Val Ser Phe Gln Pro Leu Ala Arg Ser Thr Pro Arg Ala Ser Arg Leu 
225                 230                 235                 240 


Pro Gly Pro Thr Gly Ser Val Val Ser Thr Gly Thr Ser Phe Ser Ser 
                245                 250                 255     


Ser Ser Pro Gly Leu Ala Ser Ala Gly Ala Ala Glu Gly Lys Gln Gly 
            260                 265                 270         


Ala Glu Ser Asp Gln Ala Glu Pro Ile Ile Cys Ser Ser Gly Ala Glu 
        275                 280                 285             


Ala Pro Ala Asn Ser Leu Pro Ser Lys Val Pro Thr Thr Leu Met Pro 
    290                 295                 300                 


Val Asn Thr Val Ala Leu Lys Val Pro Ala Asn Pro Ala Ser Val Ser 
305                 310                 315                 320 


Thr Val Pro Ser Lys Leu Pro Thr Ser Ser Lys Pro Pro Gly Ala Val 
                325                 330                 335     


Pro Ser Asn Ala Leu Thr Asn Pro Ala Pro Ser Lys Leu Pro Ile Asn 
            340                 345                 350         


Ser Thr Arg Ala Gly Met Val Pro Ser Lys Val Pro Thr Ser Met Val 
        355                 360                 365             


Leu Thr Lys Val Ser Ala Ser Thr Val Pro Thr Asp Gly Ser Ser Arg 
    370                 375                 380                 


Asn Glu Glu Thr Pro Ala Ala Pro Thr Pro Ala Gly Ala Thr Gly Gly 
385                 390                 395                 400 


Ser Ser Ala Trp Leu Asp Ser Ser Ser Glu Asn Arg Gly Leu Gly Ser 
                405                 410                 415     


Glu Leu Ser Lys Pro Gly Val Leu Ala Ser Gln Val Asp Ser Pro Phe 
            420                 425                 430         


Ser Gly Cys Phe Glu Asp Leu Ala Ile Ser Ala Ser Thr Ser Leu Gly 
        435                 440                 445             


Met Gly Pro Cys His Gly Pro Glu Glu Asn Glu Tyr Lys Ser Glu Gly 
    450                 455                 460                 


Thr Phe Gly Ile His Val Ala Glu Asn Pro Ser Ile Gln Leu Leu Glu 
465                 470                 475                 480 


Gly Asn Pro Gly Pro Pro Ala Asp Pro Asp Gly Gly Pro Arg Pro Gln 
                485                 490                 495     


Ala Asp Arg Lys Phe Gln Glu Arg Glu Val Pro Cys His Arg Pro Ser 
            500                 505                 510         


Pro Gly Ala Leu Trp Leu Gln Val Ala Val Thr Gly Val Leu Val Val 
        515                 520                 525             


Thr Leu Leu Val Val Leu Tyr Arg Arg Arg Leu His 
    530                 535                 540 


<210>  2
<211>  91
<212>  PRT
<213>  Homo sapiens

<400>  2

Phe Ala Glu Asp Lys Thr Tyr Lys Tyr Ile Cys Arg Asn Phe Ser Asn 
1               5                   10                  15      


Phe Cys Asn Val Asp Val Val Glu Ile Leu Pro Tyr Leu Pro Cys Leu 
            20                  25                  30          


Thr Ala Arg Asp Gln Asp Arg Leu Arg Ala Thr Cys Thr Leu Ser Gly 
        35                  40                  45              


Asn Arg Asp Thr Leu Trp His Leu Phe Asn Thr Leu Gln Arg Arg Pro 
    50                  55                  60                  


Gly Trp Val Glu Tyr Phe Ile Ala Ala Leu Arg Gly Cys Glu Leu Val 
65                  70                  75                  80  


Asp Leu Ala Asp Glu Val Ala Ser Val Tyr Gln 
                85                  90      


<210>  3
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  3

Cys Arg Ile Asp Val Val Asp Ile Ile Pro Tyr Leu Ser Glu Cys Leu 
1               5                   10                  15      


<210>  4
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  4

Cys Leu Ile Asn Gln Asp Gln Asp Cys Asp Glu Ile Arg Gln Ile 
1               5                   10                  15  


<210>  5
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  5

Cys Arg Asn Phe Ser Asn Phe 
1               5           


<210>  6
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  6

Ile Cys Arg Asn Phe Lys Ala Phe Ser Cys Asp Leu Ala Val Arg Ile 
1               5                   10                  15      


Ser Ile Leu Pro 
            20  


<210>  7
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  7

Arg Asn Phe Ser Asn Asn Val Asp Val Ile Ile Val Gln Leu Asn Glu 
1               5                   10                  15      


Ser Val Glu Ile 
            20  


<210>  8
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  8

Asn Val Glu Val Val Asp Glu Ile Leu Pro Tyr 
1               5                   10      


<210>  9
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  9

Val Glu Ile Leu Pro Tyr Leu Pro Cys 
1               5                   


<210>  10
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  10

Asp Val Leu Ile Glu Val Asp Ile Leu Pro Phe Leu Pro Cys 
1               5                   10                  


<210>  11
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  11

Ala Arg Asp Gln Asp Arg Leu Arg Ala Thr Cys Thr Leu Ser Gly Asn 
1               5                   10                  15      


Arg Asp Thr 
            


<210>  12
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide conjugated to a TAT sequence

<400>  12

Cys Arg Ile Asp Val Val Asp Ile Ile Pro Tyr Leu Ser Glu Cys Leu 
1               5                   10                  15      


<210>  13
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide conjugated to a TAT sequence

<400>  13

Cys Leu Ile Asn Gln Asp Gln Asp Cys Asp Glu Ile Arg Gln Ile 
1               5                   10                  15  


<210>  14
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide conjugated to a TAT sequence

<400>  14

Cys Arg Asn Phe Ser Asn Phe 
1               5           


<210>  15
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide conjugated to a TAT sequence

<400>  15

Ile Cys Arg Asn Phe Lys Ala Phe Ser Cys Asp Leu Ala Val Arg Ile 
1               5                   10                  15      


Ser Ile Leu Pro 
            20  


<210>  16
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide conjugated to a TAT sequence

<400>  16

Arg Asn Phe Ser Asn Asn Val Asp Val Ile Ile Val Gln Leu Asn Glu 
1               5                   10                  15      


Ser Val Glu Ile 
            20  


<210>  17
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide conjugated to a TAT sequence

<400>  17

Asn Val Glu Val Val Asp Glu Ile Leu Pro Tyr 
1               5                   10      


<210>  18
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide conjugated to a TAT sequence

<400>  18

Val Glu Ile Leu Pro Tyr Leu Pro Cys 
1               5                   


<210>  19
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide conjugated to a TAT sequence

<400>  19

Asp Val Leu Ile Glu Val Asp Ile Leu Pro Phe Leu Pro Cys 
1               5                   10                  


<210>  20
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide conjugated to a TAT sequence

<400>  20

Ala Arg Asp Gln Asp Arg Leu Arg Ala Thr Cys Thr Leu Ser Gly Asn 
1               5                   10                  15      


Arg Asp Thr 
            


<210>  21
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  21

Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Pro Gln 
1               5                   10          


<210>  22
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide

<400>  22
ccctgggggc catattaatc c                                                 21


<210>  23
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide

<400>  23
catcaaatcg cctccgagca                                                   20


