
                                SEQUENCE LISTING

<110> Fred Hutchinson Cancer Research Center
      Schmitt, Thomas M.
      Greenberg, Philip D.
      Stromnes, Ingunn M.
      Cheng, Laurence

<120> IMMUNOMODULATORY IL2R FUSION PROTIENS AND
  USES THEROF

<130> 360056.442WO

<140> PCT                 
<141> 2017-04-20  

<150> US 62/325,428       
<151> 2016-04-20  

<160> 23

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 435
<212> PRT
<213> Artificial Sequence

<220> 
<223> Fusion protein

<400> 1
Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro
 1               5                  10                  15
Ala Phe Leu Leu Ile Pro Glu Lys Ser Asp Leu Arg Thr Val Ala Pro
            20                  25                  30
Ala Ser Ser Leu Asn Val Arg Phe Asp Ser Arg Thr Met Asn Leu Ser
        35                  40                  45
Trp Asp Cys Gln Glu Asn Thr Thr Phe Ser Lys Cys Phe Leu Thr Asp
    50                  55                  60
Lys Lys Asn Arg Val Val Glu Pro Arg Leu Ser Asn Asn Glu Cys Ser
65                  70                  75                  80
Cys Thr Phe Arg Glu Ile Cys Leu His Glu Gly Val Thr Phe Glu Val
                85                  90                  95
His Val Asn Thr Ser Gln Arg Gly Phe Gln Gln Lys Leu Leu Tyr Pro
            100                 105                 110
Asn Ser Gly Arg Glu Gly Thr Ala Ala Gln Asn Phe Ser Cys Phe Ile
        115                 120                 125
Tyr Asn Ala Asp Leu Met Asn Cys Thr Trp Ala Arg Gly Pro Thr Ala
    130                 135                 140
Pro Arg Asp Val Gln Tyr Phe Leu Tyr Ile Arg Asn Ser Lys Arg Arg
145                 150                 155                 160
Arg Glu Ile Arg Cys Pro Tyr Tyr Ile Gln Asp Ser Gly Thr His Val
                165                 170                 175
Gly Cys His Leu Asp Asn Leu Ser Gly Leu Thr Ser Arg Asn Tyr Phe
            180                 185                 190
Leu Val Asn Gly Thr Ser Arg Glu Ile Gly Ile Gln Phe Phe Asp Ser
        195                 200                 205
Leu Leu Asp Thr Lys Lys Ile Glu Arg Phe Asn Pro Pro Ser Asn Val
    210                 215                 220
Thr Val Arg Cys Asn Thr Thr His Cys Leu Val Arg Trp Lys Gln Pro
225                 230                 235                 240
Arg Thr Tyr Gln Lys Leu Ser Tyr Leu Asp Phe Gln Tyr Gln Leu Asp
                245                 250                 255
Val His Arg Lys Asn Thr Gln Pro Gly Thr Glu Asn Leu Leu Ile Asn
            260                 265                 270
Val Ser Gly Asp Leu Glu Asn Arg Tyr Asn Phe Pro Ser Ser Glu Pro
        275                 280                 285
Arg Ala Lys His Ser Val Lys Ile Arg Ala Ala Asp Val Arg Ile Leu
    290                 295                 300
Asn Trp Ser Ser Trp Ser Glu Ala Ile Glu Phe Gly Ser Asp Asp Gly
305                 310                 315                 320
Pro Phe Leu Phe Ala Leu Glu Ala Val Val Ile Ser Val Gly Ser Met
                325                 330                 335
Gly Leu Ile Ile Ser Leu Leu Cys Val Tyr Phe Trp Leu Glu Arg Thr
            340                 345                 350
Met Pro Arg Ile Pro Thr Leu Lys Asn Leu Glu Asp Leu Val Thr Glu
        355                 360                 365
Tyr His Gly Asn Phe Ser Ala Trp Ser Gly Val Ser Lys Gly Leu Ala
    370                 375                 380
Glu Ser Leu Gln Pro Asp Tyr Ser Glu Arg Leu Cys Leu Val Ser Glu
385                 390                 395                 400
Ile Pro Pro Lys Gly Gly Ala Leu Gly Glu Gly Pro Gly Ala Ser Pro
                405                 410                 415
Cys Asn Gln His Ser Pro Tyr Trp Ala Pro Pro Cys Tyr Thr Leu Lys
            420                 425                 430
Pro Glu Thr
        435

<210> 2
<211> 749
<212> PRT
<213> Artificial Sequence

<220> 
<223> Fusion protein

<400> 2
Met Val Leu Ala Gln Gly Leu Leu Ser Met Ala Leu Leu Ala Leu Cys
 1               5                  10                  15
Trp Glu Arg Ser Leu Ala Gly Ala Glu Glu Thr Ile Pro Leu Gln Thr
            20                  25                  30
Leu Arg Cys Tyr Asn Asp Tyr Thr Ser His Ile Thr Cys Arg Trp Ala
        35                  40                  45
Asp Thr Gln Asp Ala Gln Arg Leu Val Asn Val Thr Leu Ile Arg Arg
    50                  55                  60
Val Asn Glu Asp Leu Leu Glu Pro Val Ser Cys Asp Leu Ser Asp Asp
65                  70                  75                  80
Met Pro Trp Ser Ala Cys Pro His Pro Arg Cys Val Pro Arg Arg Cys
                85                  90                  95
Val Ile Pro Cys Gln Ser Phe Val Val Thr Asp Val Asp Tyr Phe Ser
            100                 105                 110
Phe Gln Pro Asp Arg Pro Leu Gly Thr Arg Leu Thr Val Thr Leu Thr
        115                 120                 125
Gln His Val Gln Pro Pro Glu Pro Arg Asp Leu Gln Ile Ser Thr Asp
    130                 135                 140
Gln Asp His Phe Leu Leu Thr Trp Ser Val Ala Leu Gly Ser Pro Gln
145                 150                 155                 160
Ser His Trp Leu Ser Pro Gly Asp Leu Glu Phe Glu Val Val Tyr Lys
                165                 170                 175
Arg Leu Gln Asp Ser Trp Glu Asp Ala Ala Ile Leu Leu Ser Asn Thr
            180                 185                 190
Ser Gln Ala Thr Leu Gly Pro Glu His Leu Met Pro Ser Ser Thr Tyr
        195                 200                 205
Val Ala Arg Val Arg Thr Arg Leu Ala Pro Gly Ser Arg Leu Ser Gly
    210                 215                 220
Arg Pro Ser Lys Trp Ser Pro Glu Val Cys Trp Asp Ser Gln Pro Gly
225                 230                 235                 240
Asp Glu Ala Gln Pro Gln Asn Leu Glu Cys Phe Phe Asp Gly Ala Ala
                245                 250                 255
Val Leu Ser Cys Ser Trp Glu Val Arg Lys Glu Val Ala Ser Ser Val
            260                 265                 270
Ser Phe Gly Leu Phe Tyr Lys Pro Ser Pro Asp Ala Gly Glu Glu Glu
        275                 280                 285
Cys Ser Pro Val Leu Arg Glu Gly Leu Gly Ser Leu His Thr Arg His
    290                 295                 300
His Cys Gln Ile Pro Val Pro Asp Pro Ala Thr His Gly Gln Tyr Ile
305                 310                 315                 320
Val Ser Val Gln Pro Arg Arg Ala Glu Lys His Ile Lys Ser Ser Val
                325                 330                 335
Asn Ile Gln Met Ala Pro Pro Ser Leu Asn Val Thr Lys Asp Gly Asp
            340                 345                 350
Ser Tyr Ser Leu Arg Trp Glu Thr Met Lys Met Arg Tyr Glu His Ile
        355                 360                 365
Asp His Thr Phe Glu Ile Gln Tyr Arg Lys Asp Thr Ala Thr Trp Lys
    370                 375                 380
Asp Ser Lys Thr Glu Thr Leu Gln Asn Ala His Ser Met Ala Leu Pro
385                 390                 395                 400
Ala Leu Glu Pro Ser Thr Arg Tyr Trp Ala Arg Val Arg Val Arg Thr
                405                 410                 415
Ser Arg Thr Gly Tyr Asn Gly Ile Trp Ser Glu Trp Ser Glu Ala Arg
            420                 425                 430
Ser Trp Asp Thr Glu Ser Ile Pro Trp Leu Gly His Leu Leu Val Gly
        435                 440                 445
Leu Ser Gly Ala Phe Gly Phe Ile Ile Leu Val Tyr Leu Leu Ile Asn
    450                 455                 460
Cys Arg Asn Thr Gly Pro Trp Leu Lys Lys Val Leu Lys Cys Asn Thr
465                 470                 475                 480
Pro Asp Pro Ser Lys Phe Phe Ser Gln Leu Ser Ser Glu His Gly Gly
                485                 490                 495
Asp Val Gln Lys Trp Leu Ser Ser Pro Phe Pro Ser Ser Ser Phe Ser
            500                 505                 510
Pro Gly Gly Leu Ala Pro Glu Ile Ser Pro Leu Glu Val Leu Glu Arg
        515                 520                 525
Asp Lys Val Thr Gln Leu Leu Leu Gln Gln Asp Lys Val Pro Glu Pro
    530                 535                 540
Ala Ser Leu Ser Ser Asn His Ser Leu Thr Ser Cys Phe Thr Asn Gln
545                 550                 555                 560
Gly Tyr Phe Phe Phe His Leu Pro Asp Ala Leu Glu Ile Glu Ala Cys
                565                 570                 575
Gln Val Tyr Phe Thr Tyr Asp Pro Tyr Ser Glu Glu Asp Pro Asp Glu
            580                 585                 590
Gly Val Ala Gly Ala Pro Thr Gly Ser Ser Pro Gln Pro Leu Gln Pro
        595                 600                 605
Leu Ser Gly Glu Asp Asp Ala Tyr Cys Thr Phe Pro Ser Arg Asp Asp
    610                 615                 620
Leu Leu Leu Phe Ser Pro Ser Leu Leu Gly Gly Pro Ser Pro Pro Ser
625                 630                 635                 640
Thr Ala Pro Gly Gly Ser Gly Ala Gly Glu Glu Arg Met Pro Pro Ser
                645                 650                 655
Leu Gln Glu Arg Val Pro Arg Asp Trp Asp Pro Gln Pro Leu Gly Pro
            660                 665                 670
Pro Thr Pro Gly Val Pro Asp Leu Val Asp Phe Gln Pro Pro Pro Glu
        675                 680                 685
Leu Val Leu Arg Glu Ala Gly Glu Glu Val Pro Asp Ala Gly Pro Arg
    690                 695                 700
Glu Gly Val Ser Phe Pro Trp Ser Arg Pro Pro Gly Gln Gly Glu Phe
705                 710                 715                 720
Arg Ala Leu Asn Ala Arg Leu Pro Leu Asn Thr Asp Ala Tyr Leu Ser
                725                 730                 735
Leu Gln Glu Leu Gln Gly Gln Asp Pro Thr His Leu Val
            740                 745

<210> 3
<211> 441
<212> PRT
<213> Artificial Sequence

<220> 
<223> Fusion protein

<400> 3
Met Thr Ser Ser His Ala Met Asn Ile Thr Pro Leu Ala Gln Leu Ala
 1               5                  10                  15
Leu Leu Phe Ser Thr Leu Leu Leu Pro Gly Thr Gln Ala Leu Leu Ala
            20                  25                  30
Pro Thr Thr Pro Asp Ala Gly Ser Ala Leu Asn Leu Thr Phe Asp Pro
        35                  40                  45
Trp Thr Arg Thr Leu Thr Trp Ala Cys Asp Thr Ala Ala Gly Asn Val
    50                  55                  60
Thr Val Thr Ser Cys Thr Val Thr Ser Arg Glu Ala Gly Ile His Arg
65                  70                  75                  80
Arg Val Ser Pro Phe Gly Cys Arg Cys Trp Phe Arg Arg Met Met Ala
                85                  90                  95
Leu His His Gly Val Thr Leu Asp Val Asn Gly Thr Val Gly Gly Ala
            100                 105                 110
Ala Ala His Trp Arg Leu Ser Phe Val Asn Glu Gly Ala Ala Gly Ser
        115                 120                 125
Gly Ala Glu Asn Leu Thr Cys Glu Ile Arg Ala Ala Arg Phe Leu Ser
    130                 135                 140
Cys Ala Trp Arg Glu Gly Pro Ala Ala Pro Ala Asp Val Arg Tyr Ser
145                 150                 155                 160
Leu Arg Val Leu Asn Ser Thr Gly His Asp Val Ala Arg Cys Met Ala
                165                 170                 175
Asp Pro Gly Asp Asp Val Ile Thr Gln Cys Ile Ala Asn Asp Leu Ser
            180                 185                 190
Leu Leu Gly Ser Glu Ala Tyr Leu Val Val Thr Gly Arg Ser Gly Ala
        195                 200                 205
Gly Pro Val Arg Phe Leu Asp Asp Val Val Ala Thr Lys Ala Leu Glu
    210                 215                 220
Arg Leu Gly Pro Pro Arg Asp Val Thr Ala Ser Cys Asn Ser Ser His
225                 230                 235                 240
Cys Thr Val Ser Trp Ala Pro Pro Ser Thr Trp Ala Ser Leu Thr Ala
                245                 250                 255
Arg Asp Phe Gln Phe Glu Val Gln Trp Gln Ser Ala Glu Pro Gly Ser
            260                 265                 270
Thr Pro Arg Lys Val Leu Val Val Glu Glu Thr Arg Leu Ala Phe Pro
        275                 280                 285
Ser Pro Ala Pro His Gly Gly His Lys Val Lys Val Arg Ala Gly Asp
    290                 295                 300
Thr Arg Met Lys His Trp Gly Glu Trp Ser Pro Ala His Pro Leu Glu
305                 310                 315                 320
Ala Glu Asp Thr Arg Val Pro Pro Ser Leu Phe Ala Leu Glu Ala Val
                325                 330                 335
Leu Ile Pro Val Gly Thr Met Gly Leu Ile Ile Thr Leu Ile Phe Val
            340                 345                 350
Tyr Cys Trp Leu Glu Arg Met Pro Pro Ile Pro Pro Ile Lys Asn Leu
        355                 360                 365
Glu Asp Leu Val Thr Glu Tyr Gln Gly Asn Phe Ser Ala Trp Ser Gly
    370                 375                 380
Val Ser Lys Gly Leu Thr Glu Ser Leu Gln Pro Asp Tyr Ser Glu Arg
385                 390                 395                 400
Phe Cys His Val Ser Glu Ile Pro Pro Lys Gly Gly Ala Leu Gly Glu
                405                 410                 415
Gly Pro Gly Gly Ser Pro Cys Ser Leu His Ser Pro Tyr Trp Pro Pro
            420                 425                 430
Pro Cys Tyr Ser Leu Lys Pro Glu Ala
        435                 440

<210> 4
<211> 740
<212> PRT
<213> Artificial Sequence

<220> 
<223> Fusion protein

<400> 4
Met Asp Gln Gln Met Ala Leu Thr Trp Gly Leu Cys Tyr Met Ala Leu
 1               5                  10                  15
Val Ala Leu Cys Trp Gly His Gly Val Thr Glu Ala Glu Glu Thr Val
            20                  25                  30
Pro Leu Lys Thr Leu Gln Cys Tyr Asn Asp Tyr Thr Asn His Ile Ile
        35                  40                  45
Cys Ser Trp Ala Asp Thr Glu Asp Ala Gln Gly Leu Ile Asn Met Thr
    50                  55                  60
Leu Tyr His Gln Leu Glu Lys Lys Gln Pro Val Ser Cys Glu Leu Ser
65                  70                  75                  80
Glu Glu Leu Met Trp Ser Glu Cys Pro Ser Ser His Arg Cys Val Pro
                85                  90                  95
Arg Arg Cys Val Ile Pro Tyr Thr Arg Phe Ser Ile Thr Asn Glu Asp
            100                 105                 110
Tyr Tyr Ser Phe Arg Pro Asp Ser Asp Leu Gly Ile Gln Leu Met Val
        115                 120                 125
Pro Leu Ala Gln Asn Val Gln Pro Pro Leu Pro Lys Asn Val Ser Ile
    130                 135                 140
Ser Ser Ser Glu Asp Arg Phe Leu Leu Glu Trp Ser Val Ser Leu Gly
145                 150                 155                 160
Asp Ala Gln Val Ser Trp Leu Ser Ser Lys Asp Ile Glu Phe Glu Val
                165                 170                 175
Ala Tyr Lys Arg Leu Gln Asp Ser Trp Glu Asp Ala Tyr Ser Leu His
            180                 185                 190
Thr Ser Lys Phe Gln Val Asn Phe Glu Pro Lys Leu Phe Leu Pro Asn
        195                 200                 205
Ser Ile Tyr Ala Ala Arg Val Arg Thr Arg Leu Ser Pro Gly Ser Ser
    210                 215                 220
Leu Ser Gly Arg Pro Ser Arg Trp Ser Pro Glu Val His Trp Asp Ser
225                 230                 235                 240
Gln Pro Gly Asp Lys Ala Gln Pro Gln Asn Leu Gln Cys Phe Phe Asp
                245                 250                 255
Gly Ile Gln Ser Leu His Cys Ser Trp Glu Val Trp Thr Gln Thr Thr
            260                 265                 270
Gly Ser Val Ser Phe Gly Leu Phe Tyr Arg Pro Ser Pro Val Ala Pro
        275                 280                 285
Glu Glu Lys Cys Ser Pro Val Val Lys Glu Pro Pro Gly Ala Ser Val
    290                 295                 300
Tyr Thr Arg Tyr His Cys Ser Leu Pro Val Pro Glu Pro Ser Ala His
305                 310                 315                 320
Ser Gln Tyr Thr Val Ser Val Lys His Leu Glu Gln Gly Lys Phe Ile
                325                 330                 335
Met Ser Tyr Asn His Ile Gln Met Glu Pro Pro Thr Leu Asn Leu Thr
            340                 345                 350
Lys Asn Arg Asp Ser Tyr Ser Leu His Trp Glu Thr Gln Lys Met Ala
        355                 360                 365
Tyr Ser Phe Ile Glu His Thr Phe Gln Val Gln Tyr Lys Lys Lys Ser
    370                 375                 380
Asp Ser Trp Glu Asp Ser Lys Thr Glu Asn Leu Asp Arg Ala His Ser
385                 390                 395                 400
Met Asp Leu Ser Gln Leu Glu Pro Asp Thr Ser Tyr Cys Ala Arg Val
                405                 410                 415
Arg Val Lys Pro Ile Ser Asn Tyr Asp Gly Ile Trp Ser Lys Trp Ser
            420                 425                 430
Glu Glu Tyr Thr Trp Lys Thr Asp Trp Ile Leu Pro Met Ser Trp Leu
        435                 440                 445
Arg Tyr Leu Leu Leu Val Leu Gly Cys Phe Ser Gly Phe Phe Ser Cys
    450                 455                 460
Val Tyr Ile Leu Val Lys Cys Arg Tyr Leu Gly Pro Trp Leu Lys Thr
465                 470                 475                 480
Val Leu Lys Cys His Ile Pro Asp Pro Ser Glu Phe Phe Ser Gln Leu
                485                 490                 495
Ser Ser Gln His Gly Gly Asp Leu Gln Lys Trp Leu Ser Ser Pro Val
            500                 505                 510
Pro Leu Ser Phe Phe Ser Pro Ser Gly Pro Ala Pro Glu Ile Ser Pro
        515                 520                 525
Leu Glu Val Leu Asp Gly Asp Ser Lys Ala Val Gln Leu Leu Leu Leu
    530                 535                 540
Gln Lys Asp Ser Ala Pro Leu Pro Ser Pro Ser Gly His Ser Gln Ala
545                 550                 555                 560
Ser Cys Phe Thr Asn Gln Gly Tyr Phe Phe Phe His Leu Pro Asn Ala
                565                 570                 575
Leu Glu Ile Glu Ser Cys Gln Val Tyr Phe Thr Tyr Asp Pro Cys Val
            580                 585                 590
Glu Glu Glu Val Glu Glu Asp Gly Ser Arg Leu Pro Glu Gly Ser Pro
        595                 600                 605
His Pro Pro Leu Leu Pro Leu Ala Gly Glu Gln Asp Asp Tyr Cys Ala
    610                 615                 620
Phe Pro Pro Arg Asp Asp Leu Leu Leu Phe Ser Pro Ser Leu Ser Thr
625                 630                 635                 640
Pro Asn Thr Ala Tyr Gly Gly Ser Arg Ala Pro Glu Glu Arg Ser Pro
                645                 650                 655
Leu Ser Leu His Glu Gly Leu Pro Ser Leu Ala Ser Arg Asp Leu Met
            660                 665                 670
Gly Leu Gln Arg Pro Leu Glu Arg Met Pro Glu Gly Asp Gly Glu Gly
        675                 680                 685
Leu Ser Ala Asn Ser Ser Gly Glu Gln Ala Ser Val Pro Glu Gly Asn
    690                 695                 700
Leu His Gly Gln Asp Gln Asp Arg Gly Gln Gly Pro Ile Leu Thr Leu
705                 710                 715                 720
Asn Thr Asp Ala Tyr Leu Ser Leu Gln Glu Leu Gln Ala Gln Asp Ser
                725                 730                 735
Val His Leu Ile
            740

<210> 5
<211> 1203
<212> PRT
<213> Artificial Sequence

<220> 
<223> Fusion protein

<400> 5
Met Thr Ser Ser His Ala Met Asn Ile Thr Pro Leu Ala Gln Leu Ala
 1               5                  10                  15
Leu Leu Phe Ser Thr Leu Leu Leu Pro Gly Thr Gln Ala Leu Leu Ala
            20                  25                  30
Pro Thr Thr Pro Asp Ala Gly Ser Ala Leu Asn Leu Thr Phe Asp Pro
        35                  40                  45
Trp Thr Arg Thr Leu Thr Trp Ala Cys Asp Thr Ala Ala Gly Asn Val
    50                  55                  60
Thr Val Thr Ser Cys Thr Val Thr Ser Arg Glu Ala Gly Ile His Arg
65                  70                  75                  80
Arg Val Ser Pro Phe Gly Cys Arg Cys Trp Phe Arg Arg Met Met Ala
                85                  90                  95
Leu His His Gly Val Thr Leu Asp Val Asn Gly Thr Val Gly Gly Ala
            100                 105                 110
Ala Ala His Trp Arg Leu Ser Phe Val Asn Glu Gly Ala Ala Gly Ser
        115                 120                 125
Gly Ala Glu Asn Leu Thr Cys Glu Ile Arg Ala Ala Arg Phe Leu Ser
    130                 135                 140
Cys Ala Trp Arg Glu Gly Pro Ala Ala Pro Ala Asp Val Arg Tyr Ser
145                 150                 155                 160
Leu Arg Val Leu Asn Ser Thr Gly His Asp Val Ala Arg Cys Met Ala
                165                 170                 175
Asp Pro Gly Asp Asp Val Ile Thr Gln Cys Ile Ala Asn Asp Leu Ser
            180                 185                 190
Leu Leu Gly Ser Glu Ala Tyr Leu Val Val Thr Gly Arg Ser Gly Ala
        195                 200                 205
Gly Pro Val Arg Phe Leu Asp Asp Val Val Ala Thr Lys Ala Leu Glu
    210                 215                 220
Arg Leu Gly Pro Pro Arg Asp Val Thr Ala Ser Cys Asn Ser Ser His
225                 230                 235                 240
Cys Thr Val Ser Trp Ala Pro Pro Ser Thr Trp Ala Ser Leu Thr Ala
                245                 250                 255
Arg Asp Phe Gln Phe Glu Val Gln Trp Gln Ser Ala Glu Pro Gly Ser
            260                 265                 270
Thr Pro Arg Lys Val Leu Val Val Glu Glu Thr Arg Leu Ala Phe Pro
        275                 280                 285
Ser Pro Ala Pro His Gly Gly His Lys Val Lys Val Arg Ala Gly Asp
    290                 295                 300
Thr Arg Met Lys His Trp Gly Glu Trp Ser Pro Ala His Pro Leu Glu
305                 310                 315                 320
Ala Glu Asp Thr Arg Val Pro Pro Ser Leu Phe Ala Leu Glu Ala Val
                325                 330                 335
Leu Ile Pro Val Gly Thr Met Gly Leu Ile Ile Thr Leu Ile Phe Val
            340                 345                 350
Tyr Cys Trp Leu Glu Arg Met Pro Pro Ile Pro Pro Ile Lys Asn Leu
        355                 360                 365
Glu Asp Leu Val Thr Glu Tyr Gln Gly Asn Phe Ser Ala Trp Ser Gly
    370                 375                 380
Val Ser Lys Gly Leu Thr Glu Ser Leu Gln Pro Asp Tyr Ser Glu Arg
385                 390                 395                 400
Phe Cys His Val Ser Glu Ile Pro Pro Lys Gly Gly Ala Leu Gly Glu
                405                 410                 415
Gly Pro Gly Gly Ser Pro Cys Ser Leu His Ser Pro Tyr Trp Pro Pro
            420                 425                 430
Pro Cys Tyr Ser Leu Lys Pro Glu Ala Gly Ser Gly Ala Thr Asn Phe
        435                 440                 445
Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met
    450                 455                 460
Asp Gln Gln Met Ala Leu Thr Trp Gly Leu Cys Tyr Met Ala Leu Val
465                 470                 475                 480
Ala Leu Cys Trp Gly His Gly Val Thr Glu Ala Glu Glu Thr Val Pro
                485                 490                 495
Leu Lys Thr Leu Gln Cys Tyr Asn Asp Tyr Thr Asn His Ile Ile Cys
            500                 505                 510
Ser Trp Ala Asp Thr Glu Asp Ala Gln Gly Leu Ile Asn Met Thr Leu
        515                 520                 525
Tyr His Gln Leu Glu Lys Lys Gln Pro Val Ser Cys Glu Leu Ser Glu
    530                 535                 540
Glu Leu Met Trp Ser Glu Cys Pro Ser Ser His Arg Cys Val Pro Arg
545                 550                 555                 560
Arg Cys Val Ile Pro Tyr Thr Arg Phe Ser Ile Thr Asn Glu Asp Tyr
                565                 570                 575
Tyr Ser Phe Arg Pro Asp Ser Asp Leu Gly Ile Gln Leu Met Val Pro
            580                 585                 590
Leu Ala Gln Asn Val Gln Pro Pro Leu Pro Lys Asn Val Ser Ile Ser
        595                 600                 605
Ser Ser Glu Asp Arg Phe Leu Leu Glu Trp Ser Val Ser Leu Gly Asp
    610                 615                 620
Ala Gln Val Ser Trp Leu Ser Ser Lys Asp Ile Glu Phe Glu Val Ala
625                 630                 635                 640
Tyr Lys Arg Leu Gln Asp Ser Trp Glu Asp Ala Tyr Ser Leu His Thr
                645                 650                 655
Ser Lys Phe Gln Val Asn Phe Glu Pro Lys Leu Phe Leu Pro Asn Ser
            660                 665                 670
Ile Tyr Ala Ala Arg Val Arg Thr Arg Leu Ser Pro Gly Ser Ser Leu
        675                 680                 685
Ser Gly Arg Pro Ser Arg Trp Ser Pro Glu Val His Trp Asp Ser Gln
    690                 695                 700
Pro Gly Asp Lys Ala Gln Pro Gln Asn Leu Gln Cys Phe Phe Asp Gly
705                 710                 715                 720
Ile Gln Ser Leu His Cys Ser Trp Glu Val Trp Thr Gln Thr Thr Gly
                725                 730                 735
Ser Val Ser Phe Gly Leu Phe Tyr Arg Pro Ser Pro Val Ala Pro Glu
            740                 745                 750
Glu Lys Cys Ser Pro Val Val Lys Glu Pro Pro Gly Ala Ser Val Tyr
        755                 760                 765
Thr Arg Tyr His Cys Ser Leu Pro Val Pro Glu Pro Ser Ala His Ser
    770                 775                 780
Gln Tyr Thr Val Ser Val Lys His Leu Glu Gln Gly Lys Phe Ile Met
785                 790                 795                 800
Ser Tyr Asn His Ile Gln Met Glu Pro Pro Thr Leu Asn Leu Thr Lys
                805                 810                 815
Asn Arg Asp Ser Tyr Ser Leu His Trp Glu Thr Gln Lys Met Ala Tyr
            820                 825                 830
Ser Phe Ile Glu His Thr Phe Gln Val Gln Tyr Lys Lys Lys Ser Asp
        835                 840                 845
Ser Trp Glu Asp Ser Lys Thr Glu Asn Leu Asp Arg Ala His Ser Met
    850                 855                 860
Asp Leu Ser Gln Leu Glu Pro Asp Thr Ser Tyr Cys Ala Arg Val Arg
865                 870                 875                 880
Val Lys Pro Ile Ser Asn Tyr Asp Gly Ile Trp Ser Lys Trp Ser Glu
                885                 890                 895
Glu Tyr Thr Trp Lys Thr Asp Trp Ile Leu Pro Met Ser Trp Leu Arg
            900                 905                 910
Tyr Leu Leu Leu Val Leu Gly Cys Phe Ser Gly Phe Phe Ser Cys Val
        915                 920                 925
Tyr Ile Leu Val Lys Cys Arg Tyr Leu Gly Pro Trp Leu Lys Thr Val
    930                 935                 940
Leu Lys Cys His Ile Pro Asp Pro Ser Glu Phe Phe Ser Gln Leu Ser
945                 950                 955                 960
Ser Gln His Gly Gly Asp Leu Gln Lys Trp Leu Ser Ser Pro Val Pro
                965                 970                 975
Leu Ser Phe Phe Ser Pro Ser Gly Pro Ala Pro Glu Ile Ser Pro Leu
            980                 985                 990
Glu Val Leu Asp Gly Asp Ser Lys Ala Val Gln Leu Leu Leu Leu Gln
        995                 1000                1005
Lys Asp Ser Ala Pro Leu Pro Ser Pro Ser Gly His Ser Gln Ala Ser
    1010                1015                1020
Cys Phe Thr Asn Gln Gly Tyr Phe Phe Phe His Leu Pro Asn Ala Leu
1025                1030                1035                1040
Glu Ile Glu Ser Cys Gln Val Tyr Phe Thr Tyr Asp Pro Cys Val Glu
                1045                1050                1055
Glu Glu Val Glu Glu Asp Gly Ser Arg Leu Pro Glu Gly Ser Pro His
            1060                1065                1070
Pro Pro Leu Leu Pro Leu Ala Gly Glu Gln Asp Asp Tyr Cys Ala Phe
        1075                1080                1085
Pro Pro Arg Asp Asp Leu Leu Leu Phe Ser Pro Ser Leu Ser Thr Pro
    1090                1095                1100
Asn Thr Ala Tyr Gly Gly Ser Arg Ala Pro Glu Glu Arg Ser Pro Leu
1105                1110                1115                1120
Ser Leu His Glu Gly Leu Pro Ser Leu Ala Ser Arg Asp Leu Met Gly
                1125                1130                1135
Leu Gln Arg Pro Leu Glu Arg Met Pro Glu Gly Asp Gly Glu Gly Leu
            1140                1145                1150
Ser Ala Asn Ser Ser Gly Glu Gln Ala Ser Val Pro Glu Gly Asn Leu
        1155                1160                1165
His Gly Gln Asp Gln Asp Arg Gly Gln Gly Pro Ile Leu Thr Leu Asn
    1170                1175                1180
Thr Asp Ala Tyr Leu Ser Leu Gln Glu Leu Gln Ala Gln Asp Ser Val
1185                1190                1195                1200
His Leu Ile


<210> 6
<211> 1308
<212> DNA
<213> Artificial Sequence

<220> 
<223> Fusion sequence
      

<400> 6
atgcttctcc tggtgacaag ccttctgctc tgtgagttac cacacccagc attcctcctg      60
atcccagaga aatcggatct gcgaacagtg gcaccagcct ctagtctcaa tgtgaggttt     120
gactccagga cgatgaattt aagctgggac tgccaagaaa acacaacctt cagcaagtgt     180
ttcttaactg acaagaagaa cagagtcgtg gaacccaggc tcagtaacaa cgaatgttcg     240
tgcacatttc gtgaaatttg tctgcatgaa ggagtcacat ttgaggttca cgtgaatact     300
agtcaaagag gatttcaaca gaaactgctt tatccaaatt caggaaggga gggtaccgct     360
gctcagaatt tctcctgttt catctacaat gcggatttaa tgaactgtac ctgggcgagg     420
ggtccgacgg ccccccgtga cgtccagtat tttttgtaca tacgaaactc aaagagaagg     480
agggagatcc ggtgtcctta ttacatacaa gactcaggaa cccatgtggg atgtcacctg     540
gataacctgt caggattaac gtctcgcaat tactttctgg ttaacggaac cagccgagaa     600
attggcatcc aattctttga ttcacttttg gacacaaaga aaatagaacg attcaaccct     660
cccagcaatg tcaccgtacg ttgcaacacg acgcactgcc tcgtacggtg gaaacagccc     720
aggacctatc agaagctgtc gtacctggac tttcagtacc agctggacgt ccacagaaag     780
aatacccagc ctggcacgga aaacctactg attaatgttt ctggtgattt ggaaaataga     840
tacaactttc caagctctga gcccagagca aaacacagtg tgaagatcag agctgcagac     900
gtccgcatct tgaattggag ctcctggagt gaagccattg aatttggttc tgacgacggg     960
cctttcctgt ttgcattgga agccgtggtt atctctgttg gctccatggg attgattatc    1020
agccttctct gtgtgtattt ctggctggaa cggacgatgc cccgaattcc caccctgaag    1080
aacctagagg atcttgttac tgaataccac gggaactttt cggcctggag tggtgtgtct    1140
aagggactgg ctgagagtct gcagccagac tacagtgaac gactctgcct cgtcagtgag    1200
attcccccaa aaggaggggc ccttggggag gggcctgggg cctccccatg caaccagcat    1260
agcccctact gggccccccc atgttacacc ctaaagcctg aaacctga                 1308

<210> 7
<211> 2250
<212> DNA
<213> Artificial Sequence

<220> 
<223> Fusion sequence
      

<400> 7
atggtgctgg cccaggggct gctctccatg gccctgctgg ccctgtgctg ggagcgcagc      60
ctggcagggg cagaagaaac catcccgctg cagaccctgc gctgctacaa cgactacacc     120
agccacatca cctgcaggtg ggcagacacc caggatgccc agcggctcgt caacgtgacc     180
ctcattcgcc gggtgaatga ggacctcctg gagccagtgt cctgtgacct cagtgatgac     240
atgccctggt cagcctgccc ccatccccgc tgcgtgccca ggagatgtgt cattccctgc     300
cagagttttg tcgtcactga cgttgactac ttctcattcc aaccagacag gcctctgggc     360
acccggctca ccgtcactct gacccagcat gtccagcctc ctgagcccag ggacctgcag     420
atcagcaccg accaggacca cttcctgctg acctggagtg tggcccttgg gagtccccag     480
agccactggt tgtccccagg ggatctggag tttgaggtgg tctacaagcg gcttcaggac     540
tcttgggagg acgcagccat cctcctctcc aacacctccc aggccaccct ggggccagag     600
cacctcatgc ccagcagcac ctacgtggcc cgagtacgga cccgcctggc cccaggttct     660
cggctctcag gacgtcccag caagtggagc ccagaggttt gctgggactc ccagccaggg     720
gatgaggccc agccccagaa cctggagtgc ttctttgacg gggccgccgt gctcagctgc     780
tcctgggagg tgaggaagga ggtggccagc tcggtctcct ttggcctatt ctacaagccc     840
agcccagatg caggggagga agagtgctcc ccagtgctga gggaggggct cggcagcctc     900
cacaccaggc accactgcca gattcccgtg cccgaccccg cgacccacgg ccaatacatc     960
gtctctgttc agccaaggag ggcagagaaa cacataaaga gctcagtgaa catccagatg    1020
gcccctccat ccctcaacgt gaccaaggat ggagacagct acagcctgcg ctgggaaaca    1080
atgaaaatgc gatacgaaca catagaccac acatttgaga tccagtacag gaaagacacg    1140
gccacgtgga aggacagcaa gaccgagacc ctccagaacg cccacagcat ggccctgcca    1200
gccctggagc cctccaccag gtactgggcc agggtgaggg tcaggacctc ccgcaccggc    1260
tacaacggga tctggagcga gtggagtgag gcgcgctcct gggacaccga gtcgattccg    1320
tggctcggcc acctcctcgt gggcctcagc ggggcttttg gcttcatcat cttagtgtac    1380
ttgctgatca actgcaggaa caccgggcca tggctgaaga aggtcctgaa gtgtaacacc    1440
ccagacccct cgaagttctt ttcccagctg agctcagagc atggaggaga cgtccagaag    1500
tggctctctt cgcccttccc ctcatcgtcc ttcagccctg gcggcctggc acctgagatc    1560
tcgccactag aagtgctgga gagggacaag gtgacgcagc tgctcctgca gcaggacaag    1620
gtgcctgagc ccgcatcctt aagcagcaac cactcgctga ccagctgctt caccaaccag    1680
ggttacttct tcttccacct cccggatgcc ttggagatag aggcctgcca ggtgtacttt    1740
acttacgacc cctactcaga ggaagaccct gatgagggtg tggccggggc acccacaggg    1800
tcttcccccc aacccctgca gcctctgtca ggggaggacg acgcctactg caccttcccc    1860
tccagggatg acctgctgct cttctccccc agtctcctcg gtggccccag ccccccaagc    1920
actgcccctg ggggcagtgg ggccggtgaa gagaggatgc ccccttcttt gcaagaaaga    1980
gtccccagag actgggaccc ccagcccctg gggcctccca ccccaggagt cccagacctg    2040
gtggattttc agccaccccc tgagctggtg ctgcgagagg ctggggagga ggtccctgac    2100
gctggcccca gggagggagt cagtttcccc tggtccaggc ctcctgggca gggggagttc    2160
agggccctta atgctcgcct gcccctgaac actgatgcct acttgtccct ccaagaactc    2220
cagggtcagg acccaactca cttggtgtag                                     2250

<210> 8
<211> 3637
<212> DNA
<213> Artificial Sequence

<220> 
<223> Fusion sequence
      

<400> 8
atgaccagca gccacgccat gaacatcacc cccctggctc agctggccct gctgttctct      60
acactgctgc tgcctggcac ccaggcactg ctggctccta caacacctga tgccggcagc     120
gccctgaacc tgaccttcga cccttggacc agaaccctga cctgggcctg tgataccgcc     180
gctggcaacg tgaccgtgac cagctgtacc gtgacctcca gagaggccgg catccacaga     240
agagtgtccc cattcggctg cagatgctgg ttcagacgga tgatggccct gcaccacggc     300
gtgaccctgg acgtgaacgg aacagtgggc ggagccgccg ctcattggag actgagcttt     360
gtgaacgagg gcgcagctgg ctctggcgcc gagaatctga cctgcgagat cagagccgcc     420
agattcctga gctgcgcttg gagagaggga cctgccgctc ctgctgacgt gcggtactct     480
ctgagagtgc tgaacagcac cggccacgat gtggccagat gcatggctga ccctggcgac     540
gacgtgatca cccagtgtat cgccaacgac ctgagcctgc tgggcagcga ggcttacctg     600
gtcgtgacag gcagatctgg cgctggccca gtgcggttcc tggatgatgt ggtggccaca     660
aaggccctgg aaagactggg ccctcctagg gacgtgaccg ccagctgtaa cagctcccac     720
tgcaccgtgt cttgggcccc tccatctaca tgggccagcc tgacagccag agacttccag     780
ttcgaagtgc agtggcagag cgccgagcct ggcagcacac ctagaaaggt gctggtggtg     840
gaagagacaa gactggcctt ccccagccct gctcctcacg gcggacacaa agtgaaagtg     900
cgggctggcg acaccagaat gaagcactgg ggagagtggt cccccgctca ccctctggaa     960
gccgaggaca caagagtgcc ccctagcctg ttcgccctgg aagctgtgct gatccccgtg    1020
ggcacaatgg gcctgatcat caccctgatc ttcgtgtact gttggctgga aagaatgccc    1080
cccatccccc ctatcaagaa cctggaagat ctcgtgaccg agtaccaggg caacttctcc    1140
gcttggagcg gcgtgtccaa gggcctgaca gagagcctgc agcccgacta cagcgagaga    1200
ttctgccacg tgtccgagat cccccccaag ggcggagcac tgggagaagg acctggcggc    1260
agtccttgta gcctgcacag cccttactgg cccccaccct gctacagcct gaagcctgag    1320
gctggttccg gagccacgaa cttctctctg ttaaagcaag caggagacgt ggaagaaaac    1380
cccggtccca tggatcagca gatggctctg acatggggcc tgtgctacat ggccctggtg    1440
gctctgtgtt ggggccatgg cgtgacagag gccgaggaaa ccgtgcccct gaaaaccctg    1500
cagtgttaca acgactacac caatcacatc atctgtagct gggccgacac cgaggatgcc    1560
cagggactga tcaacatgac cctgtaccac cagctggaaa agaaacagcc cgtgtcctgc    1620
gagctgagcg aggaactgat gtggagcgag tgccctagca gccacagatg tgtgcctaga    1680
agatgcgtga tcccctacac cagattcagc atcaccaacg aggactacta cagcttcaga    1740
cccgacagcg acctgggaat ccagctgatg gtgcccctgg cccagaacgt gcagcctccc    1800
ctgcctaaga acgtgtccat cagcagcagc gaggaccggt tcctgctgga atggagtgtg    1860
tctctgggcg acgctcaggt gtcctggctg agcagcaagg acatcgagtt cgaggtggcc    1920
tacaagaggc tgcaggacag ctgggaggac gcctactctc tgcacaccag caagttccaa    1980
gtgaacttcg agcccaagct gttcctgccc aacagcatct acgccgccag agtgcggacc    2040
agactgagcc ctggatctag cctgagcggc agacctagca gatggtcccc tgaggtgcac    2100
tgggacagcc agcctggcga taaggctcag cctcagaacc tgcagtgctt cttcgacggc    2160
atccagtccc tgcactgcag ctgggaagtg tggacccaga ccacaggcag cgtgtccttc    2220
ggcctgttct acagaccaag ccccgtggcc cccgaagaga agtgtagccc tgtcgtgaaa    2280
gagcccccag gcgccagcgt gtacacaaga taccactgca gcctgcccgt gcccgagcct    2340
tctgctcact ctcagtacac cgtgtccgtg aagcacctgg aacagggcaa gttcatcatg    2400
agctacaacc acatccagat ggaacccccc acactgaatc tgacaaagaa cagagacagc    2460
tactccctgc attgggagac acagaagatg gcctacagct ttatcgagca cacatttcag    2520
gtgcagtaca agaagaagtc cgactcttgg gaggacagca agaccgaaaa cctggacaga    2580
gcccacagca tggacctgag tcagctggaa cccgacacca gctactgtgc ccgcgtcaga    2640
gtgaagccca tcagcaacta cgatggcatc tggtctaagt ggagcgaaga gtacacctgg    2700
aaaaccgact ggatcctgcc catgagctgg ctgagatacc tgctgctggt gctgggctgc    2760
ttcagcggct tcttcagctg cgtgtacatc ctcgtgaagt gcagatacct gggcccctgg    2820
ctgaaaaccg tgctgaagtg ccacatcccc gaccccagcg agttctttag ccagctgtct    2880
agccagcacg gcggcgacct gcagaagtgg ctgagttctc ctgtgcctct gagcttcttc    2940
tccccctccg gacctgcccc tgagatcagc ccactggaag tgctggacgg cgacagcaag    3000
gcagtgcagc ttctgctgct gcagaaagac agcgcccctc tgcctagccc tagcggacat    3060
agccaggcct cttgctttac caaccagggc tactttttct ttcatctgcc caacgctctg    3120
gaaatcgaga gctgtcaggt gtacttcacc tacgacccct gcgtggaaga ggaagtggaa    3180
gaggacggca gcagactgcc tgagggctct cctcatcctc ctctgctgcc tctggctggc    3240
gagcaggacg actactgcgc tttcccacca agggacgatc tgctgctgtt tagccccagc    3300
ctgagcaccc ccaacaccgc ttacggcgga agcagagccc ccgaggaaag aagccctctg    3360
tctctgcacg agggcctgcc ttctctggcc agcagagatc tgatgggcct gcagcggcct    3420
ctggaacgga tgcctgaagg ggatggcgag ggactgagcg ccaactctag cggagagcag    3480
gcctctgtgc cagagggcaa tctgcacggc caggaccagg atagaggcca gggcccaatc    3540
ctgaccctga acaccgatgc ctatctgagt ctgcaggaac tgcaggcaca ggactccgtg    3600
cacctgatct gagacccagc tttcttgtac aaagtgg                             3637

<210> 9
<211> 320
<212> PRT
<213> Homo sapiens

<400> 9
Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro
 1               5                  10                  15
Ala Phe Leu Leu Ile Pro Glu Lys Ser Asp Leu Arg Thr Val Ala Pro
            20                  25                  30
Ala Ser Ser Leu Asn Val Arg Phe Asp Ser Arg Thr Met Asn Leu Ser
        35                  40                  45
Trp Asp Cys Gln Glu Asn Thr Thr Phe Ser Lys Cys Phe Leu Thr Asp
    50                  55                  60
Lys Lys Asn Arg Val Val Glu Pro Arg Leu Ser Asn Asn Glu Cys Ser
65                  70                  75                  80
Cys Thr Phe Arg Glu Ile Cys Leu His Glu Gly Val Thr Phe Glu Val
                85                  90                  95
His Val Asn Thr Ser Gln Arg Gly Phe Gln Gln Lys Leu Leu Tyr Pro
            100                 105                 110
Asn Ser Gly Arg Glu Gly Thr Ala Ala Gln Asn Phe Ser Cys Phe Ile
        115                 120                 125
Tyr Asn Ala Asp Leu Met Asn Cys Thr Trp Ala Arg Gly Pro Thr Ala
    130                 135                 140
Pro Arg Asp Val Gln Tyr Phe Leu Tyr Ile Arg Asn Ser Lys Arg Arg
145                 150                 155                 160
Arg Glu Ile Arg Cys Pro Tyr Tyr Ile Gln Asp Ser Gly Thr His Val
                165                 170                 175
Gly Cys His Leu Asp Asn Leu Ser Gly Leu Thr Ser Arg Asn Tyr Phe
            180                 185                 190
Leu Val Asn Gly Thr Ser Arg Glu Ile Gly Ile Gln Phe Phe Asp Ser
        195                 200                 205
Leu Leu Asp Thr Lys Lys Ile Glu Arg Phe Asn Pro Pro Ser Asn Val
    210                 215                 220
Thr Val Arg Cys Asn Thr Thr His Cys Leu Val Arg Trp Lys Gln Pro
225                 230                 235                 240
Arg Thr Tyr Gln Lys Leu Ser Tyr Leu Asp Phe Gln Tyr Gln Leu Asp
                245                 250                 255
Val His Arg Lys Asn Thr Gln Pro Gly Thr Glu Asn Leu Leu Ile Asn
            260                 265                 270
Val Ser Gly Asp Leu Glu Asn Arg Tyr Asn Phe Pro Ser Ser Glu Pro
        275                 280                 285
Arg Ala Lys His Ser Val Lys Ile Arg Ala Ala Asp Val Arg Ile Leu
    290                 295                 300
Asn Trp Ser Ser Trp Ser Glu Ala Ile Glu Phe Gly Ser Asp Asp Gly
305                 310                 315                 320

<210> 10
<211> 115
<212> PRT
<213> Homo sapiens

<400> 10
Pro Phe Leu Phe Ala Leu Glu Ala Val Val Ile Ser Val Gly Ser Met
 1               5                  10                  15
Gly Leu Ile Ile Ser Leu Leu Cys Val Tyr Phe Trp Leu Glu Arg Thr
            20                  25                  30
Met Pro Arg Ile Pro Thr Leu Lys Asn Leu Glu Asp Leu Val Thr Glu
        35                  40                  45
Tyr His Gly Asn Phe Ser Ala Trp Ser Gly Val Ser Lys Gly Leu Ala
    50                  55                  60
Glu Ser Leu Gln Pro Asp Tyr Ser Glu Arg Leu Cys Leu Val Ser Glu
65                  70                  75                  80
Ile Pro Pro Lys Gly Gly Ala Leu Gly Glu Gly Pro Gly Ala Ser Pro
                85                  90                  95
Cys Asn Gln His Ser Pro Tyr Trp Ala Pro Pro Cys Tyr Thr Leu Lys
            100                 105                 110
Pro Glu Thr
        115

<210> 11
<211> 438
<212> PRT
<213> Homo sapiens

<400> 11
Met Val Leu Ala Gln Gly Leu Leu Ser Met Ala Leu Leu Ala Leu Cys
 1               5                  10                  15
Trp Glu Arg Ser Leu Ala Gly Ala Glu Glu Thr Ile Pro Leu Gln Thr
            20                  25                  30
Leu Arg Cys Tyr Asn Asp Tyr Thr Ser His Ile Thr Cys Arg Trp Ala
        35                  40                  45
Asp Thr Gln Asp Ala Gln Arg Leu Val Asn Val Thr Leu Ile Arg Arg
    50                  55                  60
Val Asn Glu Asp Leu Leu Glu Pro Val Ser Cys Asp Leu Ser Asp Asp
65                  70                  75                  80
Met Pro Trp Ser Ala Cys Pro His Pro Arg Cys Val Pro Arg Arg Cys
                85                  90                  95
Val Ile Pro Cys Gln Ser Phe Val Val Thr Asp Val Asp Tyr Phe Ser
            100                 105                 110
Phe Gln Pro Asp Arg Pro Leu Gly Thr Arg Leu Thr Val Thr Leu Thr
        115                 120                 125
Gln His Val Gln Pro Pro Glu Pro Arg Asp Leu Gln Ile Ser Thr Asp
    130                 135                 140
Gln Asp His Phe Leu Leu Thr Trp Ser Val Ala Leu Gly Ser Pro Gln
145                 150                 155                 160
Ser His Trp Leu Ser Pro Gly Asp Leu Glu Phe Glu Val Val Tyr Lys
                165                 170                 175
Arg Leu Gln Asp Ser Trp Glu Asp Ala Ala Ile Leu Leu Ser Asn Thr
            180                 185                 190
Ser Gln Ala Thr Leu Gly Pro Glu His Leu Met Pro Ser Ser Thr Tyr
        195                 200                 205
Val Ala Arg Val Arg Thr Arg Leu Ala Pro Gly Ser Arg Leu Ser Gly
    210                 215                 220
Arg Pro Ser Lys Trp Ser Pro Glu Val Cys Trp Asp Ser Gln Pro Gly
225                 230                 235                 240
Asp Glu Ala Gln Pro Gln Asn Leu Glu Cys Phe Phe Asp Gly Ala Ala
                245                 250                 255
Val Leu Ser Cys Ser Trp Glu Val Arg Lys Glu Val Ala Ser Ser Val
            260                 265                 270
Ser Phe Gly Leu Phe Tyr Lys Pro Ser Pro Asp Ala Gly Glu Glu Glu
        275                 280                 285
Cys Ser Pro Val Leu Arg Glu Gly Leu Gly Ser Leu His Thr Arg His
    290                 295                 300
His Cys Gln Ile Pro Val Pro Asp Pro Ala Thr His Gly Gln Tyr Ile
305                 310                 315                 320
Val Ser Val Gln Pro Arg Arg Ala Glu Lys His Ile Lys Ser Ser Val
                325                 330                 335
Asn Ile Gln Met Ala Pro Pro Ser Leu Asn Val Thr Lys Asp Gly Asp
            340                 345                 350
Ser Tyr Ser Leu Arg Trp Glu Thr Met Lys Met Arg Tyr Glu His Ile
        355                 360                 365
Asp His Thr Phe Glu Ile Gln Tyr Arg Lys Asp Thr Ala Thr Trp Lys
    370                 375                 380
Asp Ser Lys Thr Glu Thr Leu Gln Asn Ala His Ser Met Ala Leu Pro
385                 390                 395                 400
Ala Leu Glu Pro Ser Thr Arg Tyr Trp Ala Arg Val Arg Val Arg Thr
                405                 410                 415
Ser Arg Thr Gly Tyr Asn Gly Ile Trp Ser Glu Trp Ser Glu Ala Arg
            420                 425                 430
Ser Trp Asp Thr Glu Ser
        435

<210> 12
<211> 311
<212> PRT
<213> Homo sapiens

<400> 12
Ile Pro Trp Leu Gly His Leu Leu Val Gly Leu Ser Gly Ala Phe Gly
 1               5                  10                  15
Phe Ile Ile Leu Val Tyr Leu Leu Ile Asn Cys Arg Asn Thr Gly Pro
            20                  25                  30
Trp Leu Lys Lys Val Leu Lys Cys Asn Thr Pro Asp Pro Ser Lys Phe
        35                  40                  45
Phe Ser Gln Leu Ser Ser Glu His Gly Gly Asp Val Gln Lys Trp Leu
    50                  55                  60
Ser Ser Pro Phe Pro Ser Ser Ser Phe Ser Pro Gly Gly Leu Ala Pro
65                  70                  75                  80
Glu Ile Ser Pro Leu Glu Val Leu Glu Arg Asp Lys Val Thr Gln Leu
                85                  90                  95
Leu Leu Gln Gln Asp Lys Val Pro Glu Pro Ala Ser Leu Ser Ser Asn
            100                 105                 110
His Ser Leu Thr Ser Cys Phe Thr Asn Gln Gly Tyr Phe Phe Phe His
        115                 120                 125
Leu Pro Asp Ala Leu Glu Ile Glu Ala Cys Gln Val Tyr Phe Thr Tyr
    130                 135                 140
Asp Pro Tyr Ser Glu Glu Asp Pro Asp Glu Gly Val Ala Gly Ala Pro
145                 150                 155                 160
Thr Gly Ser Ser Pro Gln Pro Leu Gln Pro Leu Ser Gly Glu Asp Asp
                165                 170                 175
Ala Tyr Cys Thr Phe Pro Ser Arg Asp Asp Leu Leu Leu Phe Ser Pro
            180                 185                 190
Ser Leu Leu Gly Gly Pro Ser Pro Pro Ser Thr Ala Pro Gly Gly Ser
        195                 200                 205
Gly Ala Gly Glu Glu Arg Met Pro Pro Ser Leu Gln Glu Arg Val Pro
    210                 215                 220
Arg Asp Trp Asp Pro Gln Pro Leu Gly Pro Pro Thr Pro Gly Val Pro
225                 230                 235                 240
Asp Leu Val Asp Phe Gln Pro Pro Pro Glu Leu Val Leu Arg Glu Ala
                245                 250                 255
Gly Glu Glu Val Pro Asp Ala Gly Pro Arg Glu Gly Val Ser Phe Pro
            260                 265                 270
Trp Ser Arg Pro Pro Gly Gln Gly Glu Phe Arg Ala Leu Asn Ala Arg
        275                 280                 285
Leu Pro Leu Asn Thr Asp Ala Tyr Leu Ser Leu Gln Glu Leu Gln Gly
    290                 295                 300
Gln Asp Pro Thr His Leu Val
305                 310

<210> 13
<211> 22
<212> PRT
<213> Artificial Sequence

<220> 
<223> Porcine teschovirus-1 2A (P2A) peptide

<400> 13
Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val
 1               5                  10                  15
Glu Glu Asn Pro Gly Pro
            20

<210> 14
<211> 21
<212> PRT
<213> Artificial Sequence

<220> 
<223> Thoseaasigna virus 2A (T2A) peptide

<400> 14
Gly Ser Gly Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu
 1               5                  10                  15
Glu Asn Pro Gly Pro
            20

<210> 15
<211> 23
<212> PRT
<213> Artificial Sequence

<220> 
<223> Equine rhinitis A virus (ERAV) 2A (E2A) peptide

<400> 15
Gly Ser Gly Gln Cys Thr Asn Tyr Ala Leu Leu Lys Leu Ala Gly Asp
 1               5                  10                  15
Val Glu Ser Asn Pro Gly Pro
            20

<210> 16
<211> 25
<212> PRT
<213> Artificial Sequence

<220> 
<223> Foot-and-Mouth disease virus 2A (F2A) peptide

<400> 16
Gly Ser Gly Val Lys Gln Thr Leu Asn Phe Asp Leu Leu Lys Leu Ala
 1               5                  10                  15
Gly Asp Val Glu Ser Asn Pro Gly Pro
            20                  25

<210> 17
<211> 66
<212> DNA
<213> Artificial Sequence

<220> 
<223> Porcine teschovirus-1 2A (P2A) peptide

<400> 17
ggaagcggag ctactaactt cagcctgctg aagcaggctg gagacgtgga ggagaaccct      60
ggacct                                                                 66

<210> 18
<211> 66
<212> DNA
<213> Artificial Sequence

<220> 
<223> Porcine teschovirus-1 2A (P2A) peptide - Codon
            Optimized
      

<400> 18
ggttccggag ccacgaactt ctctctgtta aagcaagcag gagacgtgga agaaaacccc      60
ggtccc                                                                 66

<210> 19
<211> 63
<212> DNA
<213> Artificial Sequence

<220> 
<223> Thoseaasigna virus 2A (T2A) peptide

<400> 19
ggaagcggag agggcagagg aagtctgcta acatgcggtg acgtcgagga gaatcctgga      60
cct                                                                    63

<210> 20
<211> 69
<212> DNA
<213> Artificial Sequence

<220> 
<223> Equine rhinitis A virus (ERAV) 2A (E2A) peptide

<400> 20
ggaagcggac agtgtactaa ttatgctctc ttgaaattgg ctggagatgt tgagagcaac      60
cctggacct                                                              69

<210> 21
<211> 75
<212> DNA
<213> Artificial Sequence

<220> 
<223> Foot-and-Mouth disease virus 2A (F2A) peptide

<400> 21
ggaagcggag tgaaacagac tttgaatttt gaccttctca agttggcggg agacgtggag      60
tccaaccctg gacct                                                       75

<210> 22
<211> 26
<212> PRT
<213> Artificial Sequence

<220> 
<223> CSF2RA Transmembrane domain

<400> 22
Asn Leu Gly Ser Val Tyr Ile Tyr Val Leu Leu Ile Val Gly Thr Leu
 1               5                  10                  15
Val Cys Gly Ile Val Leu Gly Phe Leu Phe
            20                  25

<210> 23
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> CSF2RB Transmembrane domain

<400> 23
Val Leu Ala Leu Ile Val Ile Phe Leu Thr Ile Ala Val Leu Leu Ala
 1               5                  10                  15
Leu

