                         SEQUENCE LISTING

<110>  Roche Molecular Systems, Inc.
       RANIK , Martin
       BOURN , William
       VAN DER WALT , Eric
       DE BEER , Abre
       UYS , Gerrida
       MCEWAN , Paul
 
<120>  TRANSPOSASE COMPETITOR CONTROL SYSTEM

<130>  RMSI-007/001WO

<150>  US 62/324,683
<151>  2016-04-19

<160>  58    

<170>  PatentIn version 3.5

<210>  1
<211>  476
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  1

Met Ile Thr Ser Ala Leu His Arg Ala Ala Asp Trp Ala Lys Ser Val 
1               5                   10                  15      


Phe Ser Ser Ala Ala Leu Gly Asp Pro Arg Arg Thr Ala Arg Leu Val 
            20                  25                  30          


Asn Val Ala Ala Gln Leu Ala Lys Tyr Ser Gly Lys Ser Ile Thr Ile 
        35                  40                  45              


Ser Ser Glu Gly Ser Lys Ala Ala Gln Glu Gly Ala Tyr Arg Phe Ile 
    50                  55                  60                  


Arg Asn Pro Asn Val Ser Ala Glu Ala Ile Arg Lys Ala Gly Ala Met 
65                  70                  75                  80  


Gln Thr Val Lys Leu Ala Gln Glu Phe Pro Glu Leu Leu Ala Ile Glu 
                85                  90                  95      


Asp Thr Thr Ser Leu Ser Tyr Arg His Gln Val Ala Glu Glu Leu Gly 
            100                 105                 110         


Lys Leu Gly Ser Ile Gln Asp Lys Ser Arg Gly Trp Trp Val His Ser 
        115                 120                 125             


Val Leu Leu Leu Glu Ala Thr Thr Phe Arg Thr Val Gly Leu Leu His 
    130                 135                 140                 


Gln Glu Trp Trp Met Arg Pro Asp Asp Pro Ala Asp Ala Asp Glu Lys 
145                 150                 155                 160 


Glu Ser Gly Lys Trp Leu Ala Ala Ala Ala Thr Ser Arg Leu Arg Met 
                165                 170                 175     


Gly Ser Met Met Ser Asn Val Ile Ala Val Cys Asp Arg Glu Ala Asp 
            180                 185                 190         


Ile His Ala Tyr Leu Gln Asp Lys Leu Ala His Asn Glu Arg Phe Val 
        195                 200                 205             


Val Arg Ser Lys His Pro Arg Lys Asp Val Glu Ser Gly Leu Tyr Leu 
    210                 215                 220                 


Tyr Asp His Leu Lys Asn Gln Pro Glu Leu Gly Gly Tyr Gln Ile Ser 
225                 230                 235                 240 


Ile Pro Gln Lys Gly Val Val Asp Lys Arg Gly Lys Arg Lys Asn Arg 
                245                 250                 255     


Pro Ala Arg Lys Ala Ser Leu Ser Leu Arg Ser Gly Arg Ile Thr Leu 
            260                 265                 270         


Lys Gln Gly Asn Ile Thr Leu Asn Ala Val Leu Ala Glu Glu Ile Asn 
        275                 280                 285             


Pro Pro Lys Gly Glu Thr Pro Leu Lys Trp Leu Leu Leu Thr Ser Glu 
    290                 295                 300                 


Pro Val Glu Ser Leu Ala Gln Ala Leu Arg Val Ile Asp Ile Tyr Thr 
305                 310                 315                 320 


His Arg Trp Arg Ile Glu Glu Phe His Lys Ala Trp Lys Thr Gly Ala 
                325                 330                 335     


Gly Ala Glu Arg Gln Arg Met Glu Glu Pro Asp Asn Leu Glu Arg Met 
            340                 345                 350         


Val Ser Ile Leu Ser Phe Val Ala Val Arg Leu Leu Gln Leu Arg Glu 
        355                 360                 365             


Ser Phe Thr Pro Pro Gln Ala Leu Arg Ala Gln Gly Leu Leu Lys Glu 
    370                 375                 380                 


Ala Glu His Val Glu Ser Gln Ser Ala Glu Thr Val Leu Thr Pro Asp 
385                 390                 395                 400 


Glu Cys Gln Leu Leu Gly Tyr Leu Asp Lys Gly Lys Arg Lys Arg Lys 
                405                 410                 415     


Glu Lys Ala Gly Ser Leu Gln Trp Ala Tyr Met Ala Ile Ala Arg Leu 
            420                 425                 430         


Gly Gly Phe Met Asp Ser Lys Arg Thr Gly Ile Ala Ser Trp Gly Ala 
        435                 440                 445             


Leu Trp Glu Gly Trp Glu Ala Leu Gln Ser Lys Leu Asp Gly Phe Leu 
    450                 455                 460                 


Ala Ala Lys Asp Leu Met Ala Gln Gly Ile Lys Ile 
465                 470                 475     


<210>  2
<211>  455
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  2

Met Asn Asn Ala Gln Trp Ala Lys Ser Thr Phe Gly Gln Ala Asp Leu 
1               5                   10                  15      


Gly Asp Pro Arg Arg Thr Thr Arg Leu Val Lys Leu Ala Glu Thr Leu 
            20                  25                  30          


Ala Asn Asp Pro Gly Lys Pro Phe Val Ser Ile Thr Gln Ser Pro Ala 
        35                  40                  45              


Asp Met Glu Gly Ala Tyr Arg Phe Ile Arg Asn Glu His Val Asn Ala 
    50                  55                  60                  


Asp Ala Ile Ala Lys Ala Gly Tyr Leu Val Thr Ala Ala Gln Ala Ala 
65                  70                  75                  80  


Lys His Asn Leu Leu Leu Ala Leu Glu Asp Thr Thr Ala Ile Thr Tyr 
                85                  90                  95      


Ser His Arg Ser Val Arg Asp Glu Leu Gly His Val Asn Gln Gly Asn 
            100                 105                 110         


Asn Tyr Arg Gly Ile Leu Ala His Ser Val Leu Leu Phe Ala Pro Glu 
        115                 120                 125             


Gln Gln Glu Leu Val Gly Leu Ile Glu Gln Ser Arg Trp Thr Arg Asp 
    130                 135                 140                 


Ile Ser Thr Arg Gly Lys Lys His Val Arg Thr Gln Thr Pro Tyr Glu 
145                 150                 155                 160 


Glu Lys Glu Ser Phe Lys Trp Gln Ser Ala Ser Val Asn Leu Ser Ala 
                165                 170                 175     


Arg Leu Gly Thr Lys Met Ala Asp Val Ile Ser Val Cys Asp Arg Glu 
            180                 185                 190         


Ala Asp Ile Tyr Glu Tyr Leu Gln Tyr Lys Leu Ser Lys Gln His Arg 
        195                 200                 205             


Phe Val Val Arg Ser Met Gln Ser Arg His Ile Glu Gln Ser Glu Gln 
    210                 215                 220                 


Lys Leu Tyr Asp Tyr Ala Ala Gly Leu Glu Ser Ala Gly Gln Lys Gln 
225                 230                 235                 240 


Ile His Ile Ala Gln Lys Gly Gly Arg Lys Ala Arg Thr Ala Thr Val 
                245                 250                 255     


Asp Ile Val Phe Ala Pro Val Thr Leu Gln Val Pro Ala Asn Lys Arg 
            260                 265                 270         


Gly Glu Ser Leu Ser Leu Tyr Tyr Val Gly Cys Glu Glu Arg Ala Asp 
        275                 280                 285             


Asp Lys Asn Ala Leu Asn Trp His Leu Leu Thr Thr Glu Pro Val Gln 
    290                 295                 300                 


Ser Lys Ala Asp Ala Leu Asn Ile Ile Arg Tyr Tyr Glu His Arg Trp 
305                 310                 315                 320 


Leu Val Glu Glu Tyr His Lys Ala Trp Lys Thr Asp Gly Thr Asp Ile 
                325                 330                 335     


Glu Asn Ala Arg Leu Gln Ser Lys Asp Asn Ile Glu Arg Leu Val Thr 
            340                 345                 350         


Ile Ser Ala Phe Ile Ala Val Arg Ile Val Gln Leu Lys Phe Ala Arg 
        355                 360                 365             


Glu Gln Pro Asp Glu Ile Ser Cys Glu Gln Val Leu Ser Pro Lys Ala 
    370                 375                 380                 


Trp Lys Leu Leu Trp Ile Lys Arg Val Ser Arg Thr Leu Pro Asp Thr 
385                 390                 395                 400 


Val Pro Ser Met Lys Trp Ala Tyr Thr Glu Leu Ala Lys Leu Gly Gly 
                405                 410                 415     


Trp Lys Asp Thr Lys Gln Thr Gly Lys Ala Ser Val Lys Val Leu Trp 
            420                 425                 430         


Gln Gly Trp Phe Lys Leu Gln Thr Ile Leu Glu Gly Tyr Asp Leu Ala 
        435                 440                 445             


Lys Ser Leu Glu Ala Asp Leu 
    450                 455 


<210>  3
<211>  455
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  3

Met Asn Asn Ala Gln Trp Ala Lys Ser Thr Phe Gly Gln Ala Asp Leu 
1               5                   10                  15      


Gly Asp Pro Arg Arg Thr Thr Arg Leu Val Lys Leu Ala Glu Thr Leu 
            20                  25                  30          


Ala Asn Asp Pro Gly Lys Pro Phe Val Ser Ile Thr Gln Ser Pro Ala 
        35                  40                  45              


Asp Met Glu Gly Ala Tyr Arg Phe Ile Arg Asn Glu His Val Asn Ala 
    50                  55                  60                  


Asp Ala Ile Ala Lys Ala Gly Tyr Leu Val Thr Ala Ala Gln Ala Ala 
65                  70                  75                  80  


Lys His Asn Leu Leu Leu Ala Leu Glu Asp Thr Thr Ala Ile Thr Tyr 
                85                  90                  95      


Ser His Arg Ser Val Arg Asp Glu Leu Gly His Val Asn Gln Gly Asn 
            100                 105                 110         


Asn Tyr Arg Gly Ile Leu Ala His Ser Val Leu Leu Phe Ala Pro Glu 
        115                 120                 125             


Gln Gln Glu Leu Val Gly Leu Ile Glu Gln Ser Arg Trp Thr Arg Asp 
    130                 135                 140                 


Ile Ser Thr Arg Gly Lys Lys His Val Arg Thr Gln Thr Pro Tyr Glu 
145                 150                 155                 160 


Glu Lys Glu Ser Phe Lys Trp Gln Ser Ala Ser Val Asn Leu Ser Ala 
                165                 170                 175     


Arg Leu Gly Thr Lys Met Ala Asp Val Ile Ser Val Cys Asp Arg Glu 
            180                 185                 190         


Ala Asp Ile Tyr Glu Tyr Leu Gln Tyr Lys Leu Ser Lys Gln His Arg 
        195                 200                 205             


Phe Val Val Arg Ser Met Gln Ser Arg His Ile Glu Gln Ser Glu Gln 
    210                 215                 220                 


Lys Leu Tyr Asp Tyr Ala Ala Gly Leu Glu Ser Ala Gly Gln Lys Gln 
225                 230                 235                 240 


Ile His Ile Ala Gln Lys Gly Gly Arg Lys Ala Arg Thr Ala Thr Val 
                245                 250                 255     


Asp Ile Val Phe Ala Pro Val Thr Leu Gln Val Pro Ala Asn Lys Arg 
            260                 265                 270         


Gly Glu Ser Leu Ser Leu Tyr Tyr Val Gly Cys Glu Glu Arg Ala Asp 
        275                 280                 285             


Asp Lys Asn Ala Leu Asn Trp His Leu Leu Thr Thr Glu Pro Val Gln 
    290                 295                 300                 


Ser Lys Ala Asp Ala Leu Asn Ile Ile Arg Tyr Tyr Glu His Arg Trp 
305                 310                 315                 320 


Leu Val Glu Glu Tyr His Lys Ala Trp Lys Thr Asp Gly Thr Asp Ile 
                325                 330                 335     


Glu Asn Ala Arg Leu Gln Ser Lys Asp Asn Ile Glu Arg Leu Val Thr 
            340                 345                 350         


Ile Ser Ala Phe Ile Ala Val Arg Ile Val Gln Leu Lys Phe Ala Arg 
        355                 360                 365             


Glu Gln Pro Asp Glu Ile Ser Cys Glu Gln Val Leu Ser Pro Lys Ala 
    370                 375                 380                 


Trp Lys Leu Leu Trp Ile Lys Arg Val Ser Arg Thr Leu Pro Asp Thr 
385                 390                 395                 400 


Val Pro Ser Met Lys Trp Ala Tyr Thr Glu Leu Ala Lys Leu Gly Gly 
                405                 410                 415     


Trp Lys Asp Thr Lys Gln Thr Gly Lys Ala Ser Val Lys Val Leu Trp 
            420                 425                 430         


Gln Gly Trp Phe Lys Leu Gln Thr Ile Leu Glu Gly Tyr Asp Leu Ala 
        435                 440                 445             


Lys Ser Leu Glu Ala Asp Leu 
    450                 455 


<210>  4
<211>  476
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  4

Met Ile Thr Ser Ala Leu His Arg Ala Ala Asp Trp Ala Lys Ser Val 
1               5                   10                  15      


Phe Ser Ser Ala Ala Leu Gly Asp Pro Arg Arg Thr Ala Arg Leu Val 
            20                  25                  30          


Asn Val Ala Ala Gln Leu Ala Lys Tyr Ser Gly Lys Ser Ile Thr Ile 
        35                  40                  45              


Ser Ser Glu Gly Ser Lys Ala Ala Gln Glu Gly Ala Tyr Arg Phe Ile 
    50                  55                  60                  


Arg Asn Pro Asn Val Ser Ala Glu Ala Ile Arg Lys Ala Gly Ala Met 
65                  70                  75                  80  


Gln Thr Val Lys Leu Ala Gln Glu Phe Pro Glu Leu Leu Ala Ile Glu 
                85                  90                  95      


Asp Thr Thr Ser Leu Ser Tyr Arg His Gln Val Ala Glu Glu Leu Gly 
            100                 105                 110         


Lys Leu Gly Ser Ile Gln Asp Lys Ser Arg Gly Trp Trp Val His Ser 
        115                 120                 125             


Val Leu Leu Leu Glu Ala Thr Thr Phe Arg Thr Val Gly Leu Leu His 
    130                 135                 140                 


Gln Glu Trp Trp Met Arg Pro Asp Asp Pro Ala Asp Ala Asp Glu Lys 
145                 150                 155                 160 


Glu Ser Gly Met Trp Leu Ala Ala Ala Ala Thr Ser Arg Leu Arg Met 
                165                 170                 175     


Gly Ser Met Met Ser Asn Val Ile Ala Val Cys Asp Arg Glu Ala Asp 
            180                 185                 190         


Ile His Ala Tyr Leu Gln Asp Lys Leu Ala His Asn Glu Arg Phe Val 
        195                 200                 205             


Val Arg Ser Lys His Pro Arg Lys Asp Val Glu Ser Gly Leu Tyr Leu 
    210                 215                 220                 


Tyr Asp His Leu Lys Asn Gln Pro Glu Leu Gly Gly Tyr Gln Ile Ser 
225                 230                 235                 240 


Ile Pro Gln Lys Gly Val Val Asp Lys Arg Gly Lys Arg Lys Asn Arg 
                245                 250                 255     


Pro Ala Arg Lys Ala Ser Leu Ser Leu Arg Ser Gly Arg Ile Thr Leu 
            260                 265                 270         


Lys Gln Gly Asn Ile Thr Leu Asn Ala Val Leu Ala Glu Glu Ile Asn 
        275                 280                 285             


Pro Pro Lys Gly Glu Thr Pro Leu Lys Trp Leu Leu Leu Thr Ser Glu 
    290                 295                 300                 


Pro Val Glu Ser Leu Ala Gln Ala Leu Arg Val Ile Asp Ile Tyr Thr 
305                 310                 315                 320 


His Arg Trp Arg Ile Glu Glu Phe His Lys Ala Trp Lys Thr Gly Ala 
                325                 330                 335     


Gly Ala Glu Arg Gln Arg Met Glu Glu Pro Asp Asn Leu Glu Arg Met 
            340                 345                 350         


Val Ser Ile Leu Ser Phe Val Ala Val Arg Leu Leu Gln Leu Arg Glu 
        355                 360                 365             


Ser Phe Thr Pro Pro Gln Ala Leu Arg Ala Gln Gly Leu Leu Lys Glu 
    370                 375                 380                 


Ala Glu His Val Glu Ser Gln Ser Ala Glu Thr Val Leu Thr Pro Asp 
385                 390                 395                 400 


Glu Cys Gln Leu Leu Gly Tyr Leu Asp Lys Gly Lys Arg Lys Arg Lys 
                405                 410                 415     


Glu Lys Ala Gly Ser Leu Gln Trp Ala Tyr Met Ala Ile Ala Arg Leu 
            420                 425                 430         


Gly Gly Phe Met Asp Ser Lys Arg Thr Gly Ile Ala Ser Trp Gly Ala 
        435                 440                 445             


Leu Trp Glu Gly Trp Glu Ala Leu Gln Ser Lys Leu Asp Gly Phe Leu 
    450                 455                 460                 


Ala Ala Lys Asp Leu Met Ala Gln Gly Ile Lys Ile 
465                 470                 475     


<210>  5
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  5
agatgtgtat aagagacag                                                    19


<210>  6
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  6
tctacacata ttctctgtc                                                    19


<210>  7
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  modified_base
<222>  (19)..(19)
<223>  modification may include 3'-H, 3'-phosphate, 3'-bulky group 
       selected from the group consisting of a hexanediol, a 3-carbon 
       spacer, a triethylene glycol, a hexa-ethyleneglycol, and any 
       combination thereof.

<400>  7
agatgtgtat aagagacag                                                    19


<210>  8
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  8
tctacacata ttctctgtc                                                    19


<210>  9
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  modified_base
<222>  (19)..(19)
<223>  modification is a 3'-H

<400>  9
agatgtgtat aagagacag                                                    19


<210>  10
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  10
tctacacata ttctctgtc                                                    19


<210>  11
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  modification is a 3'-phosphate

<400>  11
agatgtgtat aagagacag                                                    19


<210>  12
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  12
tctacacata ttctctgtc                                                    19


<210>  13
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  N may include a synthetic base, a nucleotide analog (e.g. a 
       locked nucleic acid, a bridged nucleic acid, or a xeno nucleic 
       acid), an inverted base, or an abasic site.

<400>  13
agatgtgtat aagagacan                                                    19


<210>  14
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  14
tctacacata ttctctgtc                                                    19


<210>  15
<211>  476
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  15

Met Ile Thr Ser Ala Leu His Arg Ala Ala Asp Trp Ala Lys Ser Val 
1               5                   10                  15      


Phe Ser Ser Ala Ala Leu Gly Asp Pro Arg Arg Thr Ala Arg Leu Val 
            20                  25                  30          


Asn Val Ala Ala Gln Leu Ala Lys Tyr Ser Gly Lys Ser Ile Thr Ile 
        35                  40                  45              


Ser Ser Glu Gly Ser Lys Ala Ala Gln Glu Gly Ala Tyr Arg Phe Ile 
    50                  55                  60                  


Arg Asn Pro Asn Val Ser Ala Glu Ala Ile Arg Lys Ala Gly Ala Met 
65                  70                  75                  80  


Gln Thr Val Lys Leu Ala Gln Glu Phe Pro Glu Leu Leu Ala Ile Glu 
                85                  90                  95      


Asp Thr Thr Ser Leu Ser Tyr Arg His Gln Val Ala Glu Glu Leu Gly 
            100                 105                 110         


Lys Leu Gly Ser Ile Gln Asp Lys Ser Arg Gly Trp Trp Val His Ser 
        115                 120                 125             


Val Leu Leu Leu Glu Ala Thr Thr Phe Arg Thr Val Gly Leu Leu His 
    130                 135                 140                 


Gln Glu Trp Trp Met Arg Pro Asp Asp Pro Ala Asp Ala Asp Glu Lys 
145                 150                 155                 160 


Glu Ser Gly Lys Trp Leu Ala Ala Ala Ala Thr Ser Arg Leu Arg Met 
                165                 170                 175     


Gly Ser Met Met Ser Asn Val Ile Ala Val Cys Asp Arg Glu Ala Asp 
            180                 185                 190         


Ile His Ala Tyr Leu Gln Asp Lys Leu Ala His Asn Glu Arg Phe Val 
        195                 200                 205             


Val Arg Ser Lys His Pro Arg Lys Asp Val Glu Ser Gly Leu Tyr Leu 
    210                 215                 220                 


Tyr Asp His Leu Lys Asn Gln Pro Glu Leu Gly Gly Tyr Gln Ile Ser 
225                 230                 235                 240 


Ile Pro Gln Lys Gly Val Val Asp Lys Arg Gly Lys Arg Lys Asn Arg 
                245                 250                 255     


Pro Ala Arg Lys Ala Ser Leu Ser Leu Arg Ser Gly Arg Ile Thr Leu 
            260                 265                 270         


Lys Gln Gly Asn Ile Thr Leu Asn Ala Val Leu Ala Glu Glu Ile Asn 
        275                 280                 285             


Pro Pro Lys Gly Glu Thr Pro Leu Lys Trp Leu Leu Leu Thr Ser Glu 
    290                 295                 300                 


Pro Val Glu Ser Leu Ala Gln Ala Leu Arg Val Ile Asp Ile Tyr Thr 
305                 310                 315                 320 


His Arg Trp Arg Ile Glu Glu Phe His Lys Ala Trp Lys Thr Gly Ala 
                325                 330                 335     


Gly Ala Glu Arg Gln Arg Met Glu Glu Pro Asp Asn Leu Glu Arg Met 
            340                 345                 350         


Val Ser Ile Leu Ser Phe Val Ala Val Arg Leu Leu Gln Leu Arg Glu 
        355                 360                 365             


Ser Phe Thr Pro Pro Gln Ala Leu Arg Ala Gln Gly Leu Leu Lys Glu 
    370                 375                 380                 


Ala Glu His Val Glu Ser Gln Ser Ala Glu Thr Val Leu Thr Pro Asp 
385                 390                 395                 400 


Glu Cys Gln Leu Leu Gly Tyr Leu Asp Lys Gly Lys Arg Lys Arg Lys 
                405                 410                 415     


Glu Lys Ala Gly Ser Leu Gln Trp Ala Tyr Met Ala Ile Ala Arg Leu 
            420                 425                 430         


Gly Gly Phe Met Asp Ser Lys Arg Thr Gly Ile Ala Ser Trp Gly Ala 
        435                 440                 445             


Leu Trp Glu Gly Trp Glu Ala Leu Gln Ser Lys Leu Asp Gly Phe Leu 
    450                 455                 460                 


Ala Ala Lys Asp Leu Met Ala Gln Gly Ile Lys Ile 
465                 470                 475     


<210>  16
<211>  455
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  16

Met Asn Asn Ala Gln Trp Ala Lys Ser Thr Phe Gly Gln Ala Asp Leu 
1               5                   10                  15      


Gly Asp Pro Arg Arg Thr Thr Arg Leu Val Lys Leu Ala Glu Thr Leu 
            20                  25                  30          


Ala Asn Asp Pro Gly Lys Pro Phe Val Ser Ile Thr Gln Ser Pro Ala 
        35                  40                  45              


Asp Met Glu Gly Ala Tyr Arg Phe Ile Arg Asn Glu His Val Asn Ala 
    50                  55                  60                  


Asp Ala Ile Ala Lys Ala Gly Tyr Leu Val Thr Ala Ala Gln Ala Ala 
65                  70                  75                  80  


Lys His Asn Leu Leu Leu Ala Leu Glu Asp Thr Thr Ala Ile Thr Tyr 
                85                  90                  95      


Ser His Arg Ser Val Arg Asp Glu Leu Gly His Val Asn Gln Gly Asn 
            100                 105                 110         


Asn Tyr Arg Gly Ile Leu Ala His Ser Val Leu Leu Phe Ala Pro Glu 
        115                 120                 125             


Gln Gln Glu Leu Val Gly Leu Ile Glu Gln Ser Arg Trp Thr Arg Asp 
    130                 135                 140                 


Ile Ser Thr Arg Gly Lys Lys His Val Arg Thr Gln Thr Pro Tyr Glu 
145                 150                 155                 160 


Glu Lys Glu Ser Phe Lys Trp Gln Ser Ala Ser Val Asn Leu Ser Ala 
                165                 170                 175     


Arg Leu Gly Thr Lys Met Ala Asp Val Ile Ser Val Cys Asp Arg Glu 
            180                 185                 190         


Ala Asp Ile Tyr Glu Tyr Leu Gln Tyr Lys Leu Ser Lys Gln His Arg 
        195                 200                 205             


Phe Val Val Arg Ser Met Gln Ser Arg His Ile Glu Gln Ser Glu Gln 
    210                 215                 220                 


Lys Leu Tyr Asp Tyr Ala Ala Gly Leu Glu Ser Ala Gly Gln Lys Gln 
225                 230                 235                 240 


Ile His Ile Ala Gln Lys Gly Gly Arg Lys Ala Arg Thr Ala Thr Val 
                245                 250                 255     


Asp Ile Val Phe Ala Pro Val Thr Leu Gln Val Pro Ala Asn Lys Arg 
            260                 265                 270         


Gly Glu Ser Leu Ser Leu Tyr Tyr Val Gly Cys Glu Glu Arg Ala Asp 
        275                 280                 285             


Asp Lys Asn Ala Leu Asn Trp His Leu Leu Thr Thr Glu Pro Val Gln 
    290                 295                 300                 


Ser Lys Ala Asp Ala Leu Asn Ile Ile Arg Tyr Tyr Glu His Arg Trp 
305                 310                 315                 320 


Leu Val Glu Glu Tyr His Lys Ala Trp Lys Thr Asp Gly Thr Asp Ile 
                325                 330                 335     


Glu Asn Ala Arg Leu Gln Ser Lys Asp Asn Ile Glu Arg Leu Val Thr 
            340                 345                 350         


Ile Ser Ala Phe Ile Ala Val Arg Ile Val Gln Leu Lys Phe Ala Arg 
        355                 360                 365             


Glu Gln Pro Asp Glu Ile Ser Cys Glu Gln Val Leu Ser Pro Lys Ala 
    370                 375                 380                 


Trp Lys Leu Leu Trp Ile Lys Arg Val Ser Arg Thr Leu Pro Asp Thr 
385                 390                 395                 400 


Val Pro Ser Met Lys Trp Ala Tyr Thr Glu Leu Ala Lys Leu Gly Gly 
                405                 410                 415     


Trp Lys Asp Thr Lys Gln Thr Gly Lys Ala Ser Val Lys Val Leu Trp 
            420                 425                 430         


Gln Gly Trp Phe Lys Leu Gln Thr Ile Leu Glu Gly Tyr Asp Leu Ala 
        435                 440                 445             


Lys Ser Leu Glu Ala Asp Leu 
    450                 455 


<210>  17
<211>  461
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  17

Met Thr Tyr Ile Glu Pro Thr Leu Trp Ala Gln Lys Gln Phe Gly Gln 
1               5                   10                  15      


Ala His Leu Asn Asp Pro Arg Arg Thr Gln Arg Leu Val Ala Leu Ala 
            20                  25                  30          


Ala Ser Leu Ala Glu Gln Pro Gly Val Pro Val Ser Lys Leu Ile Ile 
        35                  40                  45              


Ser Pro Ala Asp Met Glu Gly Ala Tyr Arg Phe Ile Arg Asn Glu Gln 
    50                  55                  60                  


Ile Lys Ala Glu Asp Ile Ala Glu Ala Gly Phe His Val Thr Ala Gln 
65                  70                  75                  80  


Glu Ala Leu Glu Gln Gln Thr Leu Leu Ala Leu Glu Asp Thr Thr Ser 
                85                  90                  95      


Leu Ser Tyr Ser His Arg Ser Ile Gln Asp Glu Leu Gly His Ser Asn 
            100                 105                 110         


Gln Gly Asn Arg Asn Arg Ala Met Phe Ile His Ser Thr Leu Leu Phe 
        115                 120                 125             


Ala Pro Glu Thr Gln Val Val Val Gly Leu Ile Glu Gln Gln Arg Trp 
    130                 135                 140                 


Thr Arg Asp Ile Glu Lys Arg Gly Gln Gly His Gln Tyr Ala Thr Arg 
145                 150                 155                 160 


Pro Tyr Lys Glu Lys Glu Ser Tyr Lys Trp Glu Gln Ala Ser Arg His 
                165                 170                 175     


Val Ala Glu Arg Leu Gly Asp Lys Ile Ser Asp Val Ile Ser Val Cys 
            180                 185                 190         


Asp Arg Glu Ala Asp Leu Phe Glu Tyr Leu Thr Tyr Lys Gln Glu Gln 
        195                 200                 205             


Gln Gln Arg Phe Leu Val Arg Ser Met Gln Ser Arg Cys Ile Glu Glu 
    210                 215                 220                 


His Asp Asn Arg Leu Tyr Asp Tyr Ala Ser Lys Leu Gln Ser Ala Gly 
225                 230                 235                 240 


Glu Arg Val Leu Asp Ile Pro Gln Lys Gly Gly Arg Lys Ala Arg Thr 
                245                 250                 255     


Val His Leu Asp Ile Lys Tyr Ala Pro Val Thr Leu Lys Ser Pro Ala 
            260                 265                 270         


Asn Lys Lys Glu Phe Asn Asn Ile Pro Leu Tyr Tyr Val Gly Cys Ile 
        275                 280                 285             


Glu Gln Gly Glu Ser Asn Asp Lys Leu Ala Trp His Leu Leu Thr Ser 
    290                 295                 300                 


Glu Pro Ile Thr Ser Lys Glu Glu Ala Leu Lys Ile Val Ser Tyr Tyr 
305                 310                 315                 320 


Glu Leu Arg Trp Leu Ile Glu Asp Phe His Lys Val Trp Lys Ser Glu 
                325                 330                 335     


Gly Thr Gln Val Glu Gln Leu Arg Met Gln Ser Lys Asp Asn Leu Glu 
            340                 345                 350         


Arg Leu Ser Val Ile Leu Ala Phe Ile Ala Thr Arg Leu Leu Gln Leu 
        355                 360                 365             


Arg Phe Met Asn Glu Ser Asp Glu Leu Ser Lys Ser Ser Cys Glu Pro 
    370                 375                 380                 


Ile Leu Lys Gly Lys Ala Trp Lys Leu Met Trp Leu Lys Leu Glu Arg 
385                 390                 395                 400 


Lys Gly Leu Pro Lys Glu Ala Pro Asp Ile Ser Trp Ala Tyr Lys Gly 
                405                 410                 415     


Ile Ala Arg Leu Gly Gly Trp Lys Asn Thr Lys Arg Thr Gly Arg Ala 
            420                 425                 430         


Ser Ile Lys Thr Leu Trp Gln Gly Trp Phe Arg Leu Gln Thr Ile Leu 
        435                 440                 445             


Glu Gly Tyr Glu Leu Ala Lys Ser Leu Asp Ser Pro Asp 
    450                 455                 460     


<210>  18
<211>  459
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  18

Met Thr His Ser Asp Ala Lys Leu Trp Ala Gln Glu Gln Phe Gly Gln 
1               5                   10                  15      


Ala Gln Leu Lys Asp Pro Arg Arg Thr Gln Arg Leu Ile Ser Leu Ala 
            20                  25                  30          


Thr Ser Ile Ala Asn Gln Pro Gly Val Ser Val Ala Lys Leu Pro Phe 
        35                  40                  45              


Ser Pro Ala Asp Met Glu Gly Ala Tyr Arg Phe Ile Arg Asn Glu Asn 
    50                  55                  60                  


Ile Asn Ala Glu Asp Ile Ala Glu Ala Gly Phe Gln Ser Thr Val Ser 
65                  70                  75                  80  


Arg Ala Asn Glu His Lys Glu Leu Leu Ala Leu Glu Asp Thr Thr Thr 
                85                  90                  95      


Leu Ser Phe Pro His Arg Ser Ile Lys Glu Glu Leu Gly His Thr Asn 
            100                 105                 110         


Gln Gly Asp Arg Thr Arg Ala Leu His Val His Ser Thr Leu Leu Phe 
        115                 120                 125             


Ala Pro Gln Ser Gln Thr Ile Val Gly Leu Ile Glu Gln Gln Arg Trp 
    130                 135                 140                 


Ser Arg Asp Ile Thr Lys Arg Gly Gln Lys His Gln His Ala Thr Arg 
145                 150                 155                 160 


Pro Tyr Lys Glu Lys Glu Ser Tyr Lys Trp Glu Gln Ala Ser Arg Arg 
                165                 170                 175     


Val Val Glu Arg Leu Gly Asp Lys Met Leu Asp Val Ile Ser Val Cys 
            180                 185                 190         


Asp Arg Glu Ala Asp Leu Phe Glu Tyr Leu Thr Tyr Lys Arg Gln His 
        195                 200                 205             


Gln Gln Arg Phe Val Val Arg Ser Met Gln Ser Arg Cys Leu Glu Glu 
    210                 215                 220                 


His Ala Gln Lys Leu Tyr Asp Tyr Ala Gln Ala Leu Pro Ser Val Glu 
225                 230                 235                 240 


Thr Lys Ala Leu Thr Ile Pro Gln Lys Gly Gly Arg Lys Ala Arg Asn 
                245                 250                 255     


Val Lys Leu Asp Val Lys Tyr Gly Gln Val Thr Leu Lys Ala Pro Ala 
            260                 265                 270         


Asn Lys Lys Glu His Ala Gly Ile Pro Val Tyr Tyr Val Gly Cys Leu 
        275                 280                 285             


Glu Gln Gly Thr Ser Lys Asp Lys Leu Ala Trp His Leu Leu Thr Ser 
    290                 295                 300                 


Glu Pro Ile Asn Asn Val Asp Asp Ala Met Arg Ile Ile Gly Tyr Tyr 
305                 310                 315                 320 


Glu Arg Arg Trp Leu Ile Glu Asp Phe His Lys Val Trp Lys Ser Glu 
                325                 330                 335     


Gly Thr Asp Val Glu Ser Leu Arg Leu Gln Ser Lys Asp Asn Leu Glu 
            340                 345                 350         


Arg Leu Ser Val Ile Tyr Ala Phe Val Ala Thr Arg Leu Leu Ala Leu 
        355                 360                 365             


Arg Phe Met Lys Glu Val Asp Glu Leu Thr Lys Glu Ser Cys Glu Lys 
    370                 375                 380                 


Val Leu Gly Gln Lys Ala Trp Lys Leu Leu Trp Leu Lys Leu Glu Ser 
385                 390                 395                 400 


Lys Thr Leu Pro Lys Glu Val Pro Asp Met Gly Trp Ala Tyr Lys Asn 
                405                 410                 415     


Leu Ala Lys Leu Gly Gly Trp Lys Asp Thr Lys Arg Thr Gly Arg Ala 
            420                 425                 430         


Ser Ile Lys Val Leu Trp Glu Gly Trp Phe Lys Leu Gln Thr Ile Leu 
        435                 440                 445             


Glu Gly Tyr Glu Leu Ala Met Ser Leu Asp His 
    450                 455                 


<210>  19
<211>  457
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  19

Met Ile Lys Ser Asn Asn Asp Trp Ala Glu Glu Gln Phe Gly His Ala 
1               5                   10                  15      


Lys Leu Gly Asp Pro Arg Arg Thr Ala Arg Leu Val Lys Met Ala Ser 
            20                  25                  30          


Asp Leu Ala Gln His Pro Gly Lys Ser Val Val Lys Ser Ser Pro Ser 
        35                  40                  45              


Pro Ala Ser Met Glu Gly Ala Tyr Arg Phe Ile Arg Asn Asp Asn Val 
    50                  55                  60                  


Ser Ala Asp Asp Ile Ala Glu Ala Gly Phe Arg Ala Thr Val Asn Gln 
65                  70                  75                  80  


Ala His Arg Tyr Pro Leu Leu Leu Ala Ile Glu Asp Thr Thr Thr Leu 
                85                  90                  95      


Ser Tyr Lys His Arg Ser Ile Arg Ala Asp Leu Gly His Val Asn Gln 
            100                 105                 110         


Gly Asn Arg Tyr Arg Gly Leu Leu Ala His Ser Ile Leu Leu Phe Ala 
        115                 120                 125             


Pro Glu Thr Leu Asp Val Val Gly Leu Ile Glu Gln His Arg Trp Thr 
    130                 135                 140                 


Arg Asp Ile Lys Thr Arg Gly Ile Arg Arg Glu Asn Leu Lys Arg Pro 
145                 150                 155                 160 


Tyr Glu Glu Lys Glu Gly Tyr Lys Trp Glu Ser Ala Ser Arg Asn Met 
                165                 170                 175     


Ala Ala Arg Leu Gly Thr Ala Met Ala Asn Val Ile Ser Val Cys Asp 
            180                 185                 190         


Arg Glu Ala Asp Ile Tyr Asp Tyr Leu Leu Tyr Lys Ile Ala Asn Gln 
        195                 200                 205             


Gln Arg Phe Val Val Arg Ser Met Met Ser Arg His Ile Glu Glu Gly 
    210                 215                 220                 


Ser Asp Lys Leu Tyr His Phe Ala Ser Glu Leu Asn Ser Val Lys Gln 
225                 230                 235                 240 


Arg Gln Ile Gln Ile Ala Gln Arg Gly Gly Arg Lys Ala Arg Glu Val 
                245                 250                 255     


Thr Leu Asp Val Lys Tyr Ala Ala Val Thr Leu Lys Thr Pro Ala Asn 
            260                 265                 270         


Lys Lys Gly Ser Pro Ile Ser Leu Asn Tyr Val Gly Cys Ser Glu Val 
        275                 280                 285             


Gly Asp Glu Glu Lys Thr Leu Asn Trp His Ile Leu Thr Asn Glu Pro 
    290                 295                 300                 


Val Asn Ser Ala Glu Asp Ala Leu Lys Ile Ile Gly Tyr Tyr Glu Lys 
305                 310                 315                 320 


Arg Trp Leu Ile Glu Glu Tyr His Lys Val Trp Lys Ser Glu Gly Thr 
                325                 330                 335     


Gly Val Glu Asp Leu Arg Val Gln Ser Lys Asp Asn Leu Asp Arg Leu 
            340                 345                 350         


Ala Thr Ile Tyr Ala Phe Leu Ala Val Arg Ile Phe Gln Leu Lys Phe 
        355                 360                 365             


Ala Asn Glu Gln Ile Glu Asp Ile Ser Ser Glu Lys Ile Leu Ser Pro 
    370                 375                 380                 


Arg Ala Trp Lys Leu Leu Trp Leu Lys Arg Ile Lys Thr Pro Pro Pro 
385                 390                 395                 400 


Glu Glu Val Pro Thr Ala Lys Trp Ala Tyr Glu His Leu Ala Arg Leu 
                405                 410                 415     


Gly Gly Trp Lys Asp Ser Lys Arg Asn Gly Arg Ala Ser Val Lys Thr 
            420                 425                 430         


Leu Trp Glu Gly Trp Leu Lys Leu Gln Ala Ile Leu Glu Gly Tyr Glu 
        435                 440                 445             


Leu Ala Leu Ser Leu Glu Gln Asp Leu 
    450                 455         


<210>  20
<211>  342
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  20

Met Ile Thr Ser Ala Leu His Arg Ala Ala Asp Trp Ala Lys Ser Val 
1               5                   10                  15      


Phe Ser Ser Ala Ala Leu Gly Asp Pro Arg Arg Thr Ala Arg Leu Val 
            20                  25                  30          


Asn Val Ala Ala Gln Leu Ala Lys Tyr Ser Gly Lys Ser Ile Thr Ile 
        35                  40                  45              


Ser Ser Glu Gly Ser Glu Ala Met Gln Glu Gly Ala Tyr Arg Phe Ile 
    50                  55                  60                  


Arg Asn Pro Asn Val Ser Ala Glu Ala Ile Arg Lys Ala Gly Ala Met 
65                  70                  75                  80  


Gln Thr Val Lys Leu Ala Gln Glu Phe Pro Glu Leu Leu Ala Ile Glu 
                85                  90                  95      


Asp Thr Thr Ser Leu Ser Tyr Arg His Gln Val Ala Glu Glu Leu Gly 
            100                 105                 110         


Lys Leu Gly Ser Ile Gln Asp Lys Ser Arg Gly Trp Trp Val His Ser 
        115                 120                 125             


Val Leu Leu Leu Glu Ala Thr Thr Phe Arg Thr Val Gly Leu Leu His 
    130                 135                 140                 


Gln Glu Trp Trp Met Arg Pro Asp Asp Pro Ala Asp Ala Asp Glu Lys 
145                 150                 155                 160 


Glu Ser Gly Lys Trp Leu Ala Ala Ala Ala Thr Ser Arg Leu Arg Met 
                165                 170                 175     


Gly Ser Met Met Ser Asn Val Ile Ala Val Cys Asp Arg Glu Ala Asp 
            180                 185                 190         


Ile His Ala Tyr Leu Gln Asp Lys Leu Ala His Asn Glu Arg Phe Val 
        195                 200                 205             


Val Arg Ser Lys His Pro Arg Lys Asp Val Glu Ser Gly Leu Tyr Leu 
    210                 215                 220                 


Tyr Asp His Leu Lys Asn Gln Pro Glu Leu Gly Gly Tyr Gln Ile Ser 
225                 230                 235                 240 


Ile Pro Gln Lys Gly Val Val Asp Lys Arg Gly Lys Arg Lys Asn Arg 
                245                 250                 255     


Pro Ala Arg Lys Ala Ser Leu Ser Leu Arg Ser Gly Arg Ile Thr Leu 
            260                 265                 270         


Lys Gln Gly Asn Ile Thr Leu Asn Ala Val Leu Ala Glu Glu Ile Asn 
        275                 280                 285             


Pro Pro Lys Gly Glu Thr Pro Leu Lys Trp Leu Leu Leu Thr Ser Glu 
    290                 295                 300                 


Pro Val Glu Ser Leu Ala Gln Ala Leu Arg Val Ile Asp Ile Tyr Thr 
305                 310                 315                 320 


His Arg Trp Arg Ile Glu Glu Phe His Lys Ala Trp Lys Thr Gly Ala 
                325                 330                 335     


Gly Ala Glu Arg Gln Arg 
            340         


<210>  21
<211>  342
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  21

Met Ile Thr Ser Ala Leu His Arg Ala Ala Asp Trp Ala Lys Ser Val 
1               5                   10                  15      


Phe Ser Ser Ala Ala Leu Gly Asp Pro Arg Arg Thr Ala Arg Leu Val 
            20                  25                  30          


Asn Val Ala Ala Gln Leu Ala Lys Tyr Ser Gly Lys Ser Ile Thr Ile 
        35                  40                  45              


Ser Ser Glu Gly Ser Lys Ala Ala Gln Glu Gly Ala Tyr Arg Phe Ile 
    50                  55                  60                  


Arg Asn Pro Asn Val Ser Ala Glu Ala Ile Arg Lys Ala Gly Ala Met 
65                  70                  75                  80  


Gln Thr Val Lys Leu Ala Gln Glu Phe Pro Glu Leu Leu Ala Ile Glu 
                85                  90                  95      


Asp Thr Thr Ser Leu Ser Tyr Arg His Gln Val Ala Glu Glu Leu Gly 
            100                 105                 110         


Lys Leu Gly Ser Ile Gln Asp Lys Ser Arg Gly Trp Trp Val His Ser 
        115                 120                 125             


Val Leu Leu Leu Glu Ala Thr Thr Phe Arg Thr Val Gly Leu Leu His 
    130                 135                 140                 


Gln Glu Trp Trp Met Arg Pro Asp Asp Pro Ala Asp Ala Asp Glu Lys 
145                 150                 155                 160 


Glu Ser Gly Lys Trp Leu Ala Ala Ala Ala Thr Ser Arg Leu Arg Met 
                165                 170                 175     


Gly Ser Met Met Ser Asn Val Ile Ala Val Cys Asp Arg Glu Ala Asp 
            180                 185                 190         


Ile His Ala Tyr Leu Gln Asp Lys Leu Ala His Asn Glu Arg Phe Val 
        195                 200                 205             


Val Arg Ser Lys His Pro Arg Lys Asp Val Glu Ser Gly Leu Tyr Leu 
    210                 215                 220                 


Tyr Asp His Leu Lys Asn Gln Pro Glu Leu Gly Gly Tyr Gln Ile Ser 
225                 230                 235                 240 


Ile Pro Gln Lys Gly Val Val Asp Lys Arg Gly Lys Arg Lys Asn Arg 
                245                 250                 255     


Pro Ala Arg Lys Ala Ser Leu Ser Leu Arg Ser Gly Arg Ile Thr Leu 
            260                 265                 270         


Lys Gln Gly Asn Ile Thr Leu Asn Ala Val Leu Ala Glu Glu Ile Asn 
        275                 280                 285             


Pro Pro Lys Gly Glu Thr Pro Leu Lys Trp Leu Leu Leu Thr Ser Glu 
    290                 295                 300                 


Pro Val Glu Ser Leu Ala Gln Ala Leu Arg Val Ile Asp Ile Tyr Thr 
305                 310                 315                 320 


His Arg Trp Arg Ile Glu Glu Phe His Lys Ala Trp Lys Thr Gly Ala 
                325                 330                 335     


Gly Ala Glu Arg Gln Arg 
            340         


<210>  22
<211>  340
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protein

<400>  22

Met Asn Asn Ala Gln Trp Ala Lys Ser Thr Phe Gly Gln Ala Asp Leu 
1               5                   10                  15      


Gly Asp Pro Arg Arg Thr Thr Arg Leu Val Lys Leu Ala Glu Thr Leu 
            20                  25                  30          


Ala Asn Asp Pro Gly Lys Pro Phe Val Ser Ile Thr Gln Ser Pro Ala 
        35                  40                  45              


Asp Met Glu Gly Ala Tyr Arg Phe Ile Arg Asn Glu His Val Asn Ala 
    50                  55                  60                  


Asp Ala Ile Ala Lys Ala Gly Tyr Leu Val Thr Ala Ala Gln Ala Ala 
65                  70                  75                  80  


Lys His Asn Leu Leu Leu Ala Leu Glu Asp Thr Thr Ala Ile Thr Tyr 
                85                  90                  95      


Ser His Arg Ser Val Arg Asp Glu Leu Gly His Val Asn Gln Gly Asn 
            100                 105                 110         


Asn Tyr Arg Gly Ile Leu Ala His Ser Val Leu Leu Phe Ala Pro Glu 
        115                 120                 125             


Gln Gln Glu Leu Val Gly Leu Ile Glu Gln Ser Arg Trp Thr Arg Asp 
    130                 135                 140                 


Ile Ser Thr Arg Gly Lys Lys His Val Arg Thr Gln Thr Pro Tyr Glu 
145                 150                 155                 160 


Glu Lys Glu Ser Phe Lys Trp Gln Ser Ala Ser Val Asn Leu Ser Ala 
                165                 170                 175     


Arg Leu Gly Thr Lys Met Ala Asp Val Ile Ser Val Cys Asp Arg Glu 
            180                 185                 190         


Ala Asp Ile Tyr Glu Tyr Leu Gln Tyr Lys Leu Ser Lys Gln His Arg 
        195                 200                 205             


Phe Val Val Arg Ser Met Gln Ser Arg His Ile Glu Gln Ser Glu Gln 
    210                 215                 220                 


Lys Leu Tyr Asp Tyr Ala Ala Gly Leu Glu Ser Ala Gly Gln Lys Gln 
225                 230                 235                 240 


Ile His Ile Ala Gln Lys Gly Gly Arg Lys Ala Arg Thr Ala Thr Val 
                245                 250                 255     


Asp Ile Val Phe Ala Pro Val Thr Leu Gln Val Pro Ala Asn Lys Arg 
            260                 265                 270         


Gly Glu Ser Leu Ser Leu Tyr Tyr Val Gly Cys Glu Glu Arg Ala Asp 
        275                 280                 285             


Asp Lys Asn Ala Leu Asn Trp His Leu Leu Thr Thr Glu Pro Val Gln 
    290                 295                 300                 


Ser Lys Ala Asp Ala Leu Asn Ile Ile Arg Tyr Tyr Glu His Arg Trp 
305                 310                 315                 320 


Leu Val Glu Glu Tyr His Lys Ala Trp Lys Thr Asp Gly Thr Asp Ile 
                325                 330                 335     


Glu Asn Ala Arg 
            340 


<210>  23
<211>  342
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  23

Met Ile Lys Ser Asn Asn Asp Trp Ala Glu Glu Gln Phe Gly His Ala 
1               5                   10                  15      


Lys Leu Gly Asp Pro Arg Arg Thr Ala Arg Leu Val Lys Met Ala Ser 
            20                  25                  30          


Asp Leu Ala Gln His Pro Gly Lys Ser Val Val Lys Ser Ser Pro Ser 
        35                  40                  45              


Pro Ala Ser Met Glu Gly Ala Tyr Arg Phe Ile Arg Asn Asp Asn Val 
    50                  55                  60                  


Ser Ala Asp Asp Ile Ala Glu Ala Gly Phe Arg Ala Thr Val Asn Gln 
65                  70                  75                  80  


Ala His Arg Tyr Pro Leu Leu Leu Ala Ile Glu Asp Thr Thr Thr Leu 
                85                  90                  95      


Ser Tyr Lys His Arg Ser Ile Arg Ala Asp Leu Gly His Val Asn Gln 
            100                 105                 110         


Gly Asn Arg Tyr Arg Gly Leu Leu Ala His Ser Ile Leu Leu Phe Ala 
        115                 120                 125             


Pro Glu Thr Leu Asp Val Val Gly Leu Ile Glu Gln His Arg Trp Thr 
    130                 135                 140                 


Arg Asp Ile Lys Thr Arg Gly Ile Arg Arg Glu Asn Leu Lys Arg Pro 
145                 150                 155                 160 


Tyr Glu Glu Lys Glu Gly Tyr Lys Trp Glu Ser Ala Ser Arg Asn Met 
                165                 170                 175     


Ala Ala Arg Leu Gly Thr Ala Met Ala Asn Val Ile Ser Val Cys Asp 
            180                 185                 190         


Arg Glu Ala Asp Ile Tyr Asp Tyr Leu Leu Tyr Lys Ile Ala Asn Gln 
        195                 200                 205             


Gln Arg Phe Val Val Arg Ser Met Met Ser Arg His Ile Glu Glu Gly 
    210                 215                 220                 


Ser Asp Lys Leu Tyr His Phe Ala Ser Glu Leu Asn Ser Val Lys Gln 
225                 230                 235                 240 


Arg Gln Ile Gln Ile Ala Gln Arg Gly Gly Arg Lys Ala Arg Glu Val 
                245                 250                 255     


Thr Leu Asp Val Lys Tyr Ala Ala Val Thr Leu Lys Thr Pro Ala Asn 
            260                 265                 270         


Lys Lys Gly Ser Pro Ile Ser Leu Asn Tyr Val Gly Cys Ser Glu Val 
        275                 280                 285             


Gly Asp Glu Glu Lys Thr Leu Asn Trp His Ile Leu Thr Asn Glu Pro 
    290                 295                 300                 


Val Asn Ser Ala Glu Asp Ala Leu Lys Ile Ile Gly Tyr Tyr Glu Lys 
305                 310                 315                 320 


Arg Trp Leu Ile Glu Glu Tyr His Lys Val Trp Lys Ser Glu Gly Thr 
                325                 330                 335     


Gly Val Glu Asp Leu Arg 
            340         


<210>  24
<211>  344
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  24

Met Thr Tyr Ile Glu Pro Thr Leu Trp Ala Gln Lys Gln Phe Gly Gln 
1               5                   10                  15      


Ala His Leu Asn Asp Pro Arg Arg Thr Gln Arg Leu Val Ala Leu Ala 
            20                  25                  30          


Ala Ser Leu Ala Glu Gln Pro Gly Val Pro Val Ser Lys Leu Ile Ile 
        35                  40                  45              


Ser Pro Ala Asp Met Glu Gly Ala Tyr Arg Phe Ile Arg Asn Glu Gln 
    50                  55                  60                  


Ile Lys Ala Glu Asp Ile Ala Glu Ala Gly Phe His Val Thr Ala Gln 
65                  70                  75                  80  


Glu Ala Leu Glu Gln Gln Thr Leu Leu Ala Leu Glu Asp Thr Thr Ser 
                85                  90                  95      


Leu Ser Tyr Ser His Arg Ser Ile Gln Asp Glu Leu Gly His Ser Asn 
            100                 105                 110         


Gln Gly Asn Arg Asn Arg Ala Met Phe Ile His Ser Thr Leu Leu Phe 
        115                 120                 125             


Ala Pro Glu Thr Gln Val Val Val Gly Leu Ile Glu Gln Gln Arg Trp 
    130                 135                 140                 


Thr Arg Asp Ile Glu Lys Arg Gly Gln Gly His Gln Tyr Ala Thr Arg 
145                 150                 155                 160 


Pro Tyr Lys Glu Lys Glu Ser Tyr Lys Trp Glu Gln Ala Ser Arg His 
                165                 170                 175     


Val Ala Glu Arg Leu Gly Asp Lys Ile Ser Asp Val Ile Ser Val Cys 
            180                 185                 190         


Asp Arg Glu Ala Asp Leu Phe Glu Tyr Leu Thr Tyr Lys Gln Glu Gln 
        195                 200                 205             


Gln Gln Arg Phe Leu Val Arg Ser Met Gln Ser Arg Cys Ile Glu Glu 
    210                 215                 220                 


His Asp Asn Arg Leu Tyr Asp Tyr Ala Ser Lys Leu Gln Ser Ala Gly 
225                 230                 235                 240 


Glu Arg Val Leu Asp Ile Pro Gln Lys Gly Gly Arg Lys Ala Arg Thr 
                245                 250                 255     


Val His Leu Asp Ile Lys Tyr Ala Pro Val Thr Leu Lys Ser Pro Ala 
            260                 265                 270         


Asn Lys Lys Glu Phe Asn Asn Ile Pro Leu Tyr Tyr Val Gly Cys Ile 
        275                 280                 285             


Glu Gln Gly Glu Ser Asn Asp Lys Leu Ala Trp His Leu Leu Thr Ser 
    290                 295                 300                 


Glu Pro Ile Thr Ser Lys Glu Glu Ala Leu Lys Ile Val Ser Tyr Tyr 
305                 310                 315                 320 


Glu Leu Arg Trp Leu Ile Glu Asp Phe His Lys Val Trp Lys Ser Glu 
                325                 330                 335     


Gly Thr Gln Val Glu Gln Leu Arg 
            340                 


<210>  25
<211>  344
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  25

Met Thr His Ser Asp Ala Lys Leu Trp Ala Gln Glu Gln Phe Gly Gln 
1               5                   10                  15      


Ala Gln Leu Lys Asp Pro Arg Arg Thr Gln Arg Leu Ile Ser Leu Ala 
            20                  25                  30          


Thr Ser Ile Ala Asn Gln Pro Gly Val Ser Val Ala Lys Leu Pro Phe 
        35                  40                  45              


Ser Pro Ala Asp Met Glu Gly Ala Tyr Arg Phe Ile Arg Asn Glu Asn 
    50                  55                  60                  


Ile Asn Ala Glu Asp Ile Ala Glu Ala Gly Phe Gln Ser Thr Val Ser 
65                  70                  75                  80  


Arg Ala Asn Glu His Lys Glu Leu Leu Ala Leu Glu Asp Thr Thr Thr 
                85                  90                  95      


Leu Ser Phe Pro His Arg Ser Ile Lys Glu Glu Leu Gly His Thr Asn 
            100                 105                 110         


Gln Gly Asp Arg Thr Arg Ala Leu His Val His Ser Thr Leu Leu Phe 
        115                 120                 125             


Ala Pro Gln Ser Gln Thr Ile Val Gly Leu Ile Glu Gln Gln Arg Trp 
    130                 135                 140                 


Ser Arg Asp Ile Thr Lys Arg Gly Gln Lys His Gln His Ala Thr Arg 
145                 150                 155                 160 


Pro Tyr Lys Glu Lys Glu Ser Tyr Lys Trp Glu Gln Ala Ser Arg Arg 
                165                 170                 175     


Val Val Glu Arg Leu Gly Asp Lys Met Leu Asp Val Ile Ser Val Cys 
            180                 185                 190         


Asp Arg Glu Ala Asp Leu Phe Glu Tyr Leu Thr Tyr Lys Arg Gln His 
        195                 200                 205             


Gln Gln Arg Phe Val Val Arg Ser Met Gln Ser Arg Cys Leu Glu Glu 
    210                 215                 220                 


His Ala Gln Lys Leu Tyr Asp Tyr Ala Gln Ala Leu Pro Ser Val Glu 
225                 230                 235                 240 


Thr Lys Ala Leu Thr Ile Pro Gln Lys Gly Gly Arg Lys Ala Arg Asn 
                245                 250                 255     


Val Lys Leu Asp Val Lys Tyr Gly Gln Val Thr Leu Lys Ala Pro Ala 
            260                 265                 270         


Asn Lys Lys Glu His Ala Gly Ile Pro Val Tyr Tyr Val Gly Cys Leu 
        275                 280                 285             


Glu Gln Gly Thr Ser Lys Asp Lys Leu Ala Trp His Leu Leu Thr Ser 
    290                 295                 300                 


Glu Pro Ile Asn Asn Val Asp Asp Ala Met Arg Ile Ile Gly Tyr Tyr 
305                 310                 315                 320 


Glu Arg Arg Trp Leu Ile Glu Asp Phe His Lys Val Trp Lys Ser Glu 
                325                 330                 335     


Gly Thr Asp Val Glu Ser Leu Arg 
            340                 


<210>  26
<211>  134
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  26

Met Glu Glu Pro Asp Asn Leu Glu Arg Met Val Ser Ile Leu Ser Phe 
1               5                   10                  15      


Val Ala Val Arg Leu Leu Gln Leu Arg Glu Ser Phe Thr Leu Pro Gln 
            20                  25                  30          


Ala Leu Arg Ala Gln Gly Leu Leu Lys Glu Ala Glu His Val Glu Ser 
        35                  40                  45              


Gln Ser Ala Glu Thr Val Leu Thr Pro Asp Glu Cys Gln Leu Leu Gly 
    50                  55                  60                  


Tyr Leu Asp Lys Gly Lys Arg Lys Arg Lys Glu Lys Ala Gly Ser Leu 
65                  70                  75                  80  


Gln Trp Ala Tyr Met Ala Ile Ala Arg Leu Gly Gly Phe Met Asp Ser 
                85                  90                  95      


Lys Arg Thr Gly Ile Ala Ser Trp Gly Ala Leu Trp Glu Gly Trp Glu 
            100                 105                 110         


Ala Leu Gln Ser Lys Leu Asp Gly Phe Leu Ala Ala Lys Asp Leu Met 
        115                 120                 125             


Ala Gln Gly Ile Lys Ile 
    130                 


<210>  27
<211>  134
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  27

Met Glu Glu Pro Asp Asn Leu Glu Arg Met Val Ser Ile Leu Ser Phe 
1               5                   10                  15      


Val Ala Val Arg Leu Leu Gln Leu Arg Glu Ser Phe Thr Pro Pro Gln 
            20                  25                  30          


Ala Leu Arg Ala Gln Gly Leu Leu Lys Glu Ala Glu His Val Glu Ser 
        35                  40                  45              


Gln Ser Ala Glu Thr Val Leu Thr Pro Asp Glu Cys Gln Leu Leu Gly 
    50                  55                  60                  


Tyr Leu Asp Lys Gly Lys Arg Lys Arg Lys Glu Lys Ala Gly Ser Leu 
65                  70                  75                  80  


Gln Trp Ala Tyr Met Ala Ile Ala Arg Leu Gly Gly Phe Met Asp Ser 
                85                  90                  95      


Lys Arg Thr Gly Ile Ala Ser Trp Gly Ala Leu Trp Glu Gly Trp Glu 
            100                 105                 110         


Ala Leu Gln Ser Lys Leu Asp Gly Phe Leu Ala Ala Lys Asp Leu Met 
        115                 120                 125             


Ala Gln Gly Ile Lys Ile 
    130                 


<210>  28
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  28

Leu Gln Ser Lys Asp Asn Ile Glu Arg Leu Val Thr Ile Ser Ala Phe 
1               5                   10                  15      


Ile Ala Val Arg Ile Val Gln Leu Lys Phe Ala Arg Glu Gln Pro Asp 
            20                  25                  30          


Glu Ile Ser Cys Glu Gln Val Leu Ser Pro Lys Ala Trp Lys Leu Leu 
        35                  40                  45              


Trp Ile Lys Arg Val Ser Arg Thr Leu Pro Asp Thr Val Pro Ser Met 
    50                  55                  60                  


Lys Trp Ala Tyr Thr Glu Leu Ala Lys Leu Gly Gly Trp Lys Asp Thr 
65                  70                  75                  80  


Lys Gln Thr Gly Lys Ala Ser Val Lys Val Leu Trp Gln Gly Trp Phe 
                85                  90                  95      


Lys Leu Gln Thr Ile Leu Glu Gly Tyr Asp Leu Ala Lys Ser Leu Glu 
            100                 105                 110         


Ala Asp Leu 
        115 


<210>  29
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  29

Val Gln Ser Lys Asp Asn Leu Asp Arg Leu Ala Thr Ile Tyr Ala Phe 
1               5                   10                  15      


Leu Ala Val Arg Ile Phe Gln Leu Lys Phe Ala Asn Glu Gln Ile Glu 
            20                  25                  30          


Asp Ile Ser Ser Glu Lys Ile Leu Ser Pro Arg Ala Trp Lys Leu Leu 
        35                  40                  45              


Trp Leu Lys Arg Ile Lys Thr Pro Pro Pro Glu Glu Val Pro Thr Ala 
    50                  55                  60                  


Lys Trp Ala Tyr Glu His Leu Ala Arg Leu Gly Gly Trp Lys Asp Ser 
65                  70                  75                  80  


Lys Arg Asn Gly Arg Ala Ser Val Lys Thr Leu Trp Glu Gly Trp Leu 
                85                  90                  95      


Lys Leu Gln Ala Ile Leu Glu Gly Tyr Glu Leu Ala Leu Ser Leu Glu 
            100                 105                 110         


Gln Asp Leu 
        115 


<210>  30
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  30

Met Gln Ser Lys Asp Asn Leu Glu Arg Leu Ser Val Ile Leu Ala Phe 
1               5                   10                  15      


Ile Ala Thr Arg Leu Leu Gln Leu Arg Phe Met Asn Glu Ser Asp Glu 
            20                  25                  30          


Leu Ser Lys Ser Ser Cys Glu Pro Ile Leu Lys Gly Lys Ala Trp Lys 
        35                  40                  45              


Leu Met Trp Leu Lys Leu Glu Arg Lys Gly Leu Pro Lys Glu Ala Pro 
    50                  55                  60                  


Asp Ile Ser Trp Ala Tyr Lys Gly Ile Ala Arg Leu Gly Gly Trp Lys 
65                  70                  75                  80  


Asn Thr Lys Arg Thr Gly Arg Ala Ser Ile Lys Thr Leu Trp Gln Gly 
                85                  90                  95      


Trp Phe Arg Leu Gln Thr Ile Leu Glu Gly Tyr Glu Leu Ala Lys Ser 
            100                 105                 110         


Leu Asp Ser Pro Asp 
        115         


<210>  31
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  31

Leu Gln Ser Lys Asp Asn Leu Glu Arg Leu Ser Val Ile Tyr Ala Phe 
1               5                   10                  15      


Val Ala Thr Arg Leu Leu Ala Leu Arg Phe Met Lys Glu Val Asp Glu 
            20                  25                  30          


Leu Thr Lys Glu Ser Cys Glu Lys Val Leu Gly Gln Lys Ala Trp Lys 
        35                  40                  45              


Leu Leu Trp Leu Lys Leu Glu Ser Lys Thr Leu Pro Lys Glu Val Pro 
    50                  55                  60                  


Asp Met Gly Trp Ala Tyr Lys Asn Leu Ala Lys Leu Gly Gly Trp Lys 
65                  70                  75                  80  


Asp Thr Lys Arg Thr Gly Arg Ala Ser Ile Lys Val Leu Trp Glu Gly 
                85                  90                  95      


Trp Phe Lys Leu Gln Thr Ile Leu Glu Gly Tyr Glu Leu Ala Met Ser 
            100                 105                 110         


Leu Asp His 
        115 


<210>  32
<211>  455
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  32

Met Asn Asn Ala Gln Trp Ala Lys Ser Thr Phe Gly Gln Ala Asp Leu 
1               5                   10                  15      


Gly Asp Pro Arg Arg Thr Thr Arg Leu Val Lys Leu Ala Glu Thr Leu 
            20                  25                  30          


Ala Asn Asp Pro Gly Lys Pro Phe Val Ser Ile Thr Gln Ser Lys Ala 
        35                  40                  45              


Asp Met Glu Gly Ala Tyr Arg Phe Ile Arg Asn Glu His Val Asn Ala 
    50                  55                  60                  


Asp Ala Ile Ala Lys Ala Gly Tyr Leu Val Thr Ala Ala Gln Ala Ala 
65                  70                  75                  80  


Lys His Asn Leu Leu Leu Ala Leu Glu Asp Thr Thr Ala Ile Thr Tyr 
                85                  90                  95      


Ser His Arg Ser Val Arg Asp Glu Leu Gly His Val Asn Gln Gly Asn 
            100                 105                 110         


Asn Tyr Arg Gly Ile Leu Ala His Ser Val Leu Leu Phe Ala Pro Glu 
        115                 120                 125             


Gln Gln Glu Leu Val Gly Leu Ile Glu Gln Ser Arg Trp Thr Arg Asp 
    130                 135                 140                 


Ile Ser Thr Arg Gly Lys Lys His Val Arg Thr Gln Thr Pro Tyr Glu 
145                 150                 155                 160 


Glu Lys Glu Ser Phe Lys Trp Gln Ser Ala Ser Val Asn Leu Ser Ala 
                165                 170                 175     


Arg Leu Gly Thr Lys Met Ala Asp Val Ile Ser Val Cys Asp Arg Glu 
            180                 185                 190         


Ala Asp Ile Tyr Glu Tyr Leu Gln Tyr Lys Leu Ser Lys Gln His Arg 
        195                 200                 205             


Phe Val Val Arg Ser Met Gln Ser Arg His Ile Glu Gln Ser Glu Gln 
    210                 215                 220                 


Lys Leu Tyr Asp Tyr Ala Ala Gly Leu Glu Ser Ala Gly Gln Lys Gln 
225                 230                 235                 240 


Ile His Ile Ala Gln Lys Gly Gly Arg Lys Ala Arg Thr Ala Thr Val 
                245                 250                 255     


Asp Ile Val Phe Ala Pro Val Thr Leu Gln Val Pro Ala Asn Lys Arg 
            260                 265                 270         


Gly Glu Ser Leu Ser Leu Tyr Tyr Val Gly Cys Glu Glu Arg Ala Asp 
        275                 280                 285             


Asp Lys Asn Ala Leu Asn Trp His Leu Leu Thr Thr Glu Pro Val Gln 
    290                 295                 300                 


Ser Lys Ala Asp Ala Leu Asn Ile Ile Arg Tyr Tyr Glu His Arg Trp 
305                 310                 315                 320 


Leu Val Glu Glu Tyr His Lys Ala Trp Lys Thr Asp Gly Thr Asp Ile 
                325                 330                 335     


Glu Asn Ala Arg Leu Gln Ser Lys Asp Asn Ile Glu Arg Leu Val Thr 
            340                 345                 350         


Ile Ser Ala Phe Ile Ala Val Arg Ile Val Gln Leu Lys Phe Ala Arg 
        355                 360                 365             


Glu Gln Pro Asp Glu Ile Ser Cys Glu Gln Val Leu Ser Pro Lys Ala 
    370                 375                 380                 


Trp Lys Leu Leu Trp Ile Lys Arg Val Ser Arg Thr Leu Pro Asp Thr 
385                 390                 395                 400 


Val Pro Ser Met Lys Trp Ala Tyr Thr Glu Leu Ala Lys Leu Gly Gly 
                405                 410                 415     


Trp Lys Asp Thr Lys Gln Thr Gly Lys Ala Ser Val Lys Val Leu Trp 
            420                 425                 430         


Gln Gly Trp Phe Lys Leu Gln Thr Ile Leu Glu Gly Tyr Asp Leu Ala 
        435                 440                 445             


Lys Ser Leu Glu Ala Asp Leu 
    450                 455 


<210>  33
<211>  455
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  33

Met Asn Asn Ala Gln Trp Ala Lys Ser Thr Phe Gly Gln Ala Asp Leu 
1               5                   10                  15      


Gly Asp Pro Arg Arg Thr Thr Arg Leu Val Lys Leu Ala Glu Thr Leu 
            20                  25                  30          


Ala Asn Asp Pro Gly Lys Pro Phe Val Ser Ile Thr Gln Ser Pro Ala 
        35                  40                  45              


Asp Ala Glu Gly Ala Tyr Arg Phe Ile Arg Asn Glu His Val Asn Ala 
    50                  55                  60                  


Asp Ala Ile Ala Lys Ala Gly Tyr Leu Val Thr Ala Ala Gln Ala Ala 
65                  70                  75                  80  


Lys His Asn Leu Leu Leu Ala Leu Glu Asp Thr Thr Ala Ile Thr Tyr 
                85                  90                  95      


Ser His Arg Ser Val Arg Asp Glu Leu Gly His Val Asn Gln Gly Asn 
            100                 105                 110         


Asn Tyr Arg Gly Ile Leu Ala His Ser Val Leu Leu Phe Ala Pro Glu 
        115                 120                 125             


Gln Gln Glu Leu Val Gly Leu Ile Glu Gln Ser Arg Trp Thr Arg Asp 
    130                 135                 140                 


Ile Ser Thr Arg Gly Lys Lys His Val Arg Thr Gln Thr Pro Tyr Glu 
145                 150                 155                 160 


Glu Lys Glu Ser Phe Lys Trp Gln Ser Ala Ser Val Asn Leu Ser Ala 
                165                 170                 175     


Arg Leu Gly Thr Lys Met Ala Asp Val Ile Ser Val Cys Asp Arg Glu 
            180                 185                 190         


Ala Asp Ile Tyr Glu Tyr Leu Gln Tyr Lys Leu Ser Lys Gln His Arg 
        195                 200                 205             


Phe Val Val Arg Ser Met Gln Ser Arg His Ile Glu Gln Ser Glu Gln 
    210                 215                 220                 


Lys Leu Tyr Asp Tyr Ala Ala Gly Leu Glu Ser Ala Gly Gln Lys Gln 
225                 230                 235                 240 


Ile His Ile Ala Gln Lys Gly Gly Arg Lys Ala Arg Thr Ala Thr Val 
                245                 250                 255     


Asp Ile Val Phe Ala Pro Val Thr Leu Gln Val Pro Ala Asn Lys Arg 
            260                 265                 270         


Gly Glu Ser Leu Ser Leu Tyr Tyr Val Gly Cys Glu Glu Arg Ala Asp 
        275                 280                 285             


Asp Lys Asn Ala Leu Asn Trp His Leu Leu Thr Thr Glu Pro Val Gln 
    290                 295                 300                 


Ser Lys Ala Asp Ala Leu Asn Ile Ile Arg Tyr Tyr Glu His Arg Trp 
305                 310                 315                 320 


Leu Val Glu Glu Tyr His Lys Ala Trp Lys Thr Asp Gly Thr Asp Ile 
                325                 330                 335     


Glu Asn Ala Arg Leu Gln Ser Lys Asp Asn Ile Glu Arg Leu Val Thr 
            340                 345                 350         


Ile Ser Ala Phe Ile Ala Val Arg Ile Val Gln Leu Lys Phe Ala Arg 
        355                 360                 365             


Glu Gln Pro Asp Glu Ile Ser Cys Glu Gln Val Leu Ser Pro Lys Ala 
    370                 375                 380                 


Trp Lys Leu Leu Trp Ile Lys Arg Val Ser Arg Thr Leu Pro Asp Thr 
385                 390                 395                 400 


Val Pro Ser Met Lys Trp Ala Tyr Thr Glu Leu Ala Lys Leu Gly Gly 
                405                 410                 415     


Trp Lys Asp Thr Lys Gln Thr Gly Lys Ala Ser Val Lys Val Leu Trp 
            420                 425                 430         


Gln Gly Trp Phe Lys Leu Gln Thr Ile Leu Glu Gly Tyr Asp Leu Ala 
        435                 440                 445             


Lys Ser Leu Glu Ala Asp Leu 
    450                 455 


<210>  34
<211>  455
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  34

Met Asn Asn Ala Gln Trp Ala Lys Ser Thr Phe Gly Gln Ala Asp Leu 
1               5                   10                  15      


Gly Asp Pro Arg Arg Thr Thr Arg Leu Val Lys Leu Ala Glu Thr Leu 
            20                  25                  30          


Ala Asn Asp Pro Gly Lys Pro Phe Val Ser Ile Thr Gln Ser Lys Ala 
        35                  40                  45              


Asp Ala Glu Gly Ala Tyr Arg Phe Ile Arg Asn Glu His Val Asn Ala 
    50                  55                  60                  


Asp Ala Ile Ala Lys Ala Gly Tyr Leu Val Thr Ala Ala Gln Ala Ala 
65                  70                  75                  80  


Lys His Asn Leu Leu Leu Ala Leu Glu Asp Thr Thr Ala Ile Thr Tyr 
                85                  90                  95      


Ser His Arg Ser Val Arg Asp Glu Leu Gly His Val Asn Gln Gly Asn 
            100                 105                 110         


Asn Tyr Arg Gly Ile Leu Ala His Ser Val Leu Leu Phe Ala Pro Glu 
        115                 120                 125             


Gln Gln Glu Leu Val Gly Leu Ile Glu Gln Ser Arg Trp Thr Arg Asp 
    130                 135                 140                 


Ile Ser Thr Arg Gly Lys Lys His Val Arg Thr Gln Thr Pro Tyr Glu 
145                 150                 155                 160 


Glu Lys Glu Ser Phe Lys Trp Gln Ser Ala Ser Val Asn Leu Ser Ala 
                165                 170                 175     


Arg Leu Gly Thr Lys Met Ala Asp Val Ile Ser Val Cys Asp Arg Glu 
            180                 185                 190         


Ala Asp Ile Tyr Glu Tyr Leu Gln Tyr Lys Leu Ser Lys Gln His Arg 
        195                 200                 205             


Phe Val Val Arg Ser Met Gln Ser Arg His Ile Glu Gln Ser Glu Gln 
    210                 215                 220                 


Lys Leu Tyr Asp Tyr Ala Ala Gly Leu Glu Ser Ala Gly Gln Lys Gln 
225                 230                 235                 240 


Ile His Ile Ala Gln Lys Gly Gly Arg Lys Ala Arg Thr Ala Thr Val 
                245                 250                 255     


Asp Ile Val Phe Ala Pro Val Thr Leu Gln Val Pro Ala Asn Lys Arg 
            260                 265                 270         


Gly Glu Ser Leu Ser Leu Tyr Tyr Val Gly Cys Glu Glu Arg Ala Asp 
        275                 280                 285             


Asp Lys Asn Ala Leu Asn Trp His Leu Leu Thr Thr Glu Pro Val Gln 
    290                 295                 300                 


Ser Lys Ala Asp Ala Leu Asn Ile Ile Arg Tyr Tyr Glu His Arg Trp 
305                 310                 315                 320 


Leu Val Glu Glu Tyr His Lys Ala Trp Lys Thr Asp Gly Thr Asp Ile 
                325                 330                 335     


Glu Asn Ala Arg Leu Gln Ser Lys Asp Asn Ile Glu Arg Leu Val Thr 
            340                 345                 350         


Ile Ser Ala Phe Ile Ala Val Arg Ile Val Gln Leu Lys Phe Ala Arg 
        355                 360                 365             


Glu Gln Pro Asp Glu Ile Ser Cys Glu Gln Val Leu Ser Pro Lys Ala 
    370                 375                 380                 


Trp Lys Leu Leu Trp Ile Lys Arg Val Ser Arg Thr Leu Pro Asp Thr 
385                 390                 395                 400 


Val Pro Ser Met Lys Trp Ala Tyr Thr Glu Leu Ala Lys Leu Gly Gly 
                405                 410                 415     


Trp Lys Asp Thr Lys Gln Thr Gly Lys Ala Ser Val Lys Val Leu Trp 
            420                 425                 430         


Gln Gly Trp Phe Lys Leu Gln Thr Ile Leu Glu Gly Tyr Asp Leu Ala 
        435                 440                 445             


Lys Ser Leu Glu Ala Asp Leu 
    450                 455 


<210>  35
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  35
tcgtcggcag cgtcagatgt gtataagaga cag                                    33


<210>  36
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  36
tctacacata ttctctgtc                                                    19


<210>  37
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  37
gtctcgtggg ctcggagatg tgtataagag acag                                   34


<210>  38
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  38
tctacacata ttctctgtc                                                    19


<210>  39
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  39
tcgtcggcag cgtcagatgt gtataagaga cag                                    33


<210>  40
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  40
tctacacata ttctctgtc                                                    19


<210>  41
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  41
gtctcgtggg ctcggagatg tgtataagag acag                                   34


<210>  42
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  42
tctacacata ttctctgtc                                                    19


<210>  43
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  43
tcgtcggcag cgtcagatgt gtataagaga cag                                    33


<210>  44
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  44
tctacacata ttctctgtc                                                    19


<210>  45
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  45
gtctcgtggg ctcggagatg tgtataagag acag                                   34


<210>  46
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  46
tctacacata ttctctgtc                                                    19


<210>  47
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  47
agatgtgtat aagagacag                                                    19


<210>  48
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  48
tctacacata ttctctgtc                                                    19


<210>  49
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  49
tcgtcggcag cgtcagatgt gtataagaga cag                                    33


<210>  50
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  50
tctacacata ttctctgtc                                                    19


<210>  51
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  51
gtctcgtggg ctcggagatg tgtataagag acag                                   34


<210>  52
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  52
tctacacata ttctctgtc                                                    19


<210>  53
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  modified_base
<222>  (19)..(19)
<223>  modification is a 3'-phosphate.

<400>  53
agatgtgtat aagagacag                                                    19


<210>  54
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  54
tctacacata ttctctgtc                                                    19


<210>  55
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  3'-spacer referred to as /"3SpC3"/

<400>  55
agatgtgtat aagagacag                                                    19


<210>  56
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  56
tctacacata ttctctgtc                                                    19


<210>  57
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (50)..(51)
<223>  wherein the (*) represents a phosphorothioate bond

<400>  57
aatgatacgg cgaccaccga gatctacact agatcgctcg tcggcagcgt c                51


<210>  58
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (46)..(47)
<223>  wherein the (*) represents a phosphorothioate bond

<400>  58
caagcagaag acggcatacg agattcgcct tagtctcgtg ggctcgg                     47


