                         SEQUENCE LISTING

<110>  Glusense Ltd.
 
<120>  FRET-BASED GLUCOSE-DETECTION MOLECULES

<130>  87998

<150>  US 62/325,136 

<151>  2016-04-20

<160>  12    

<170>  PatentIn version 3.5

<210>  1
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FRET-based glucose-detection molecule D274

<400>  1

Val Ser Glu Leu Ile Lys Glu Asn Met His Met Lys Leu Tyr Met Glu 
1               5                   10                  15      


Gly Thr Val Asn Asn His His Phe Lys Cys Thr Ser Glu Gly Glu Gly 
            20                  25                  30          


Lys Pro Tyr Glu Gly Thr Gln Thr Met Arg Ile Lys Ala Val Glu Gly 
        35                  40                  45              


Gly Pro Leu Pro Phe Ala Phe Asp Ile Leu Ala Thr Ser Phe Met Tyr 
    50                  55                  60                  


Gly Ser Lys Thr Phe Ile Asn His Thr Gln Gly Ile Pro Asp Phe Phe 
65                  70                  75                  80  


Lys Gln Ser Phe Pro Glu Gly Phe Thr Trp Glu Arg Val Thr Thr Tyr 
                85                  90                  95      


Glu Asp Gly Gly Val Leu Thr Ala Thr Gln Asp Thr Ser Leu Gln Asp 
            100                 105                 110         


Gly Cys Leu Ile Tyr Asn Val Lys Ile Arg Gly Val Asn Phe Pro Ser 
        115                 120                 125             


Asn Gly Pro Val Met Gln Lys Lys Thr Leu Gly Trp Glu Ala Ser Thr 
    130                 135                 140                 


Glu Thr Leu Tyr Pro Ala Asp Gly Gly Leu Glu Gly Arg Ala Asp Met 
145                 150                 155                 160 


Ala Leu Lys Leu Val Gly Gly Gly His Leu Ile Cys Asn Leu Lys Thr 
                165                 170                 175     


Thr Tyr Arg Ser Lys Lys Pro Ala Lys Asn Leu Lys Met Pro Gly Val 
            180                 185                 190         


Tyr Tyr Val Asp Arg Arg Leu Glu Arg Ile Lys Glu Ala Asp Lys Glu 
        195                 200                 205             


Thr Tyr Val Glu Gln His Glu Val Ala Val Ala Arg Tyr Cys Asp Leu 
    210                 215                 220                 


Pro Ser Lys Leu Gly His Arg Ala Asp Thr Arg Ile Gly Val Thr Ile 
225                 230                 235                 240 


Tyr Lys Tyr Asp Asp Asn Gln Met Ser Val Val Arg Lys Ala Ile Glu 
                245                 250                 255     


Gln Asp Ala Lys Ala Ala Pro Asp Val Gln Leu Leu Met Asn Asp Ser 
            260                 265                 270         


Gln Asn Asp Gln Ser Lys Gln Asn Asp Gln Ile Asp Val Leu Leu Ala 
        275                 280                 285             


Lys Gly Val Lys Ala Leu Ala Ile Asn Leu Val Asp Pro Ala Ala Ala 
    290                 295                 300                 


Gly Thr Val Ile Glu Lys Ala Arg Gly Gln Asn Val Pro Val Val Phe 
305                 310                 315                 320 


Phe Asn Lys Glu Pro Ser Arg Lys Ala Leu Asp Ser Tyr Asp Lys Ala 
                325                 330                 335     


Tyr Tyr Val Gly Thr Asp Ser Lys Glu Ser Gly Ile Ile Gln Gly Asp 
            340                 345                 350         


Leu Ile Ala Lys His Trp Ala Ala Asn Gln Gly Trp Asp Leu Asn Lys 
        355                 360                 365             


Asp Gly Gln Ile Gln Phe Val Leu Leu Lys Gly Glu Pro Gly His Pro 
    370                 375                 380                 


Asp Ala Glu Ala Arg Thr Thr Tyr Val Ile Lys Glu Leu Asn Asp Lys 
385                 390                 395                 400 


Gly Ile Lys Thr Glu Gln Leu Gln Leu Asp Thr Ala Met Trp Asp Thr 
                405                 410                 415     


Ala Gln Ala Lys Asp Lys Met Asp Ala Trp Leu Ser Gly Pro Asn Ala 
            420                 425                 430         


Asn Lys Ile Glu Val Val Ile Ala Asn Asn Asp Ala Met Ala Met Gly 
        435                 440                 445             


Ala Val Glu Ala Leu Lys Ala His Asn Lys Ser Ser Ile Pro Val Phe 
    450                 455                 460                 


Gly Val Asp Ala Leu Pro Glu Ala Leu Ala Leu Val Lys Ser Gly Ala 
465                 470                 475                 480 


Leu Ala Gly Thr Val Leu Asn Asp Ala Asn Asn Gln Ala Lys Ala Thr 
                485                 490                 495     


Phe Asp Leu Ala Lys Asn Leu Ala Asp Ser Lys Gly Glu Glu Leu Phe 
            500                 505                 510         


Thr Gly Val Val Pro Ile Leu Val Glu Leu Asp Gly Asp Val Asn Gly 
        515                 520                 525             


His Lys Phe Ser Val Arg Gly Glu Gly Glu Gly Asp Ala Thr Asn Gly 
    530                 535                 540                 


Lys Leu Thr Leu Lys Phe Ile Cys Thr Thr Gly Lys Leu Pro Val Pro 
545                 550                 555                 560 


Trp Pro Thr Leu Val Thr Thr Phe Gly Tyr Gly Val Ala Cys Phe Ser 
                565                 570                 575     


Arg Tyr Pro Asp His Met Lys Gln His Asp Phe Phe Lys Ser Ala Met 
            580                 585                 590         


Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile Ser Phe Lys Asp Asp Gly 
        595                 600                 605             


Thr Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu Gly Asp Thr Leu Val 
    610                 615                 620                 


Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp Gly Asn Ile 
625                 630                 635                 640 


Leu Gly His Lys Leu Glu Tyr Asn Phe Asn Ser His Asn Val Tyr Ile 
                645                 650                 655     


Thr Ala Asp Lys Gln Lys Asn Gly Ile Lys Ala Asn Phe Lys Ile Arg 
            660                 665                 670         


His Asn Val Glu Asp Gly Ser Val Gln Leu Ala Asp His Tyr Gln Gln 
        675                 680                 685             


Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp Asn His Tyr 
    690                 695                 700                 


Leu Ser His Gln Ser Ala Leu Ser Lys Asp Pro Asn Glu Lys Arg Asp 
705                 710                 715                 720 


His Met Val Leu Leu Glu Phe Val Thr Ala Ala Gly Ile Thr His Gly 
                725                 730                 735     


Met Asp Glu Leu Gly Ala Ala Asp Gly Thr Asn Trp Lys Ile Asp Asn 
            740                 745                 750         


Lys Val Val Arg Val Pro Tyr Val Gly Val Asp Lys Asp Asn Leu Ala 
        755                 760                 765             


Glu Phe Ser Lys Lys 
    770             


<210>  2
<211>  779
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FRET-based glucose-detection molecule D277

<400>  2

Val Ser Glu Leu Ile Lys Glu Asn Met His Met Lys Leu Tyr Met Glu 
1               5                   10                  15      


Gly Thr Val Asn Asn His His Phe Lys Cys Thr Ser Glu Gly Glu Gly 
            20                  25                  30          


Lys Pro Tyr Glu Gly Thr Gln Thr Met Arg Ile Lys Ala Val Glu Gly 
        35                  40                  45              


Gly Pro Leu Pro Phe Ala Phe Asp Ile Leu Ala Thr Ser Phe Met Tyr 
    50                  55                  60                  


Gly Ser Lys Thr Phe Ile Asn His Thr Gln Gly Ile Pro Asp Phe Phe 
65                  70                  75                  80  


Lys Gln Ser Phe Pro Glu Gly Phe Thr Trp Glu Arg Val Thr Thr Tyr 
                85                  90                  95      


Glu Asp Gly Gly Val Leu Thr Ala Thr Gln Asp Thr Ser Leu Gln Asp 
            100                 105                 110         


Gly Cys Leu Ile Tyr Asn Val Lys Ile Arg Gly Val Asn Phe Pro Ser 
        115                 120                 125             


Asn Gly Pro Val Met Gln Lys Lys Thr Leu Gly Trp Glu Ala Ser Thr 
    130                 135                 140                 


Glu Thr Leu Tyr Pro Ala Asp Gly Gly Leu Glu Gly Arg Ala Asp Met 
145                 150                 155                 160 


Ala Leu Lys Leu Val Gly Gly Gly His Leu Ile Cys Asn Leu Lys Thr 
                165                 170                 175     


Thr Tyr Arg Ser Lys Lys Pro Ala Lys Asn Leu Lys Met Pro Gly Val 
            180                 185                 190         


Tyr Tyr Val Asp Arg Arg Leu Glu Arg Ile Lys Glu Ala Asp Lys Glu 
        195                 200                 205             


Thr Tyr Val Glu Gln His Glu Val Ala Val Ala Arg Tyr Cys Asp Leu 
    210                 215                 220                 


Pro Ser Lys Leu Gly His Lys Leu Asn Gly Met Asp Glu Ala Asp Thr 
225                 230                 235                 240 


Arg Ile Gly Val Thr Ile Tyr Lys Tyr Asp Asp Asn Gln Met Ser Val 
                245                 250                 255     


Val Arg Lys Ala Ile Glu Gln Asp Ala Lys Ala Ala Pro Asp Val Gln 
            260                 265                 270         


Leu Leu Met Asn Asp Ser Gln Asn Asp Gln Ser Lys Gln Asn Asp Gln 
        275                 280                 285             


Ile Asp Val Leu Leu Ala Lys Gly Val Lys Ala Leu Ala Ile Asn Leu 
    290                 295                 300                 


Val Asp Pro Ala Ala Ala Gly Thr Val Ile Glu Lys Ala Arg Gly Gln 
305                 310                 315                 320 


Asn Val Pro Val Val Phe Phe Asn Lys Glu Pro Ser Arg Lys Ala Leu 
                325                 330                 335     


Asp Ser Tyr Asp Lys Ala Tyr Tyr Val Gly Thr Asp Ser Lys Glu Ser 
            340                 345                 350         


Gly Ile Ile Gln Gly Asp Leu Ile Ala Lys His Trp Ala Ala Asn Gln 
        355                 360                 365             


Gly Trp Asp Leu Asn Lys Asp Gly Gln Ile Gln Phe Val Leu Leu Lys 
    370                 375                 380                 


Gly Glu Pro Gly His Pro Asp Ala Glu Ala Arg Thr Thr Tyr Val Ile 
385                 390                 395                 400 


Lys Glu Leu Asn Asp Lys Gly Ile Lys Thr Glu Gln Leu Gln Leu Asp 
                405                 410                 415     


Thr Ala Met Trp Asp Thr Ala Gln Ala Lys Asp Lys Met Asp Ala Trp 
            420                 425                 430         


Leu Ser Gly Pro Asn Ala Asn Lys Ile Glu Val Val Ile Ala Asn Asn 
        435                 440                 445             


Asp Ala Met Ala Met Gly Ala Val Glu Ala Leu Lys Ala His Asn Lys 
    450                 455                 460                 


Ser Ser Ile Pro Val Phe Gly Val Asp Ala Leu Pro Glu Ala Leu Ala 
465                 470                 475                 480 


Leu Val Lys Ser Gly Ala Leu Ala Gly Thr Val Leu Asn Asp Ala Asn 
                485                 490                 495     


Asn Gln Ala Lys Ala Thr Phe Asp Leu Ala Lys Asn Leu Ala Asp Ser 
            500                 505                 510         


Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val Glu Leu 
        515                 520                 525             


Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Arg Gly Glu Gly Glu 
    530                 535                 540                 


Gly Asp Ala Thr Asn Gly Lys Leu Thr Leu Lys Phe Ile Cys Thr Thr 
545                 550                 555                 560 


Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr Phe Gly Tyr 
                565                 570                 575     


Gly Val Ala Cys Phe Ser Arg Tyr Pro Asp His Met Lys Gln His Asp 
            580                 585                 590         


Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile 
        595                 600                 605             


Ser Phe Lys Asp Asp Gly Thr Tyr Lys Thr Arg Ala Glu Val Lys Phe 
    610                 615                 620                 


Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe 
625                 630                 635                 640 


Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr Asn Phe Asn 
                645                 650                 655     


Ser His Asn Val Tyr Ile Thr Ala Asp Lys Gln Lys Asn Gly Ile Lys 
            660                 665                 670         


Ala Asn Phe Lys Ile Arg His Asn Val Glu Asp Gly Ser Val Gln Leu 
        675                 680                 685             


Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Leu 
    690                 695                 700                 


Leu Pro Asp Asn His Tyr Leu Ser His Gln Ser Ala Leu Ser Lys Asp 
705                 710                 715                 720 


Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe Val Thr Ala 
                725                 730                 735     


Ala Gly Ile Thr His Gly Met Asp Glu Leu Gly Ala Ala Asp Gly Thr 
            740                 745                 750         


Asn Trp Lys Ile Asp Asn Lys Val Val Arg Val Pro Tyr Val Gly Val 
        755                 760                 765             


Asp Lys Asp Asn Leu Ala Glu Phe Ser Lys Lys 
    770                 775                 


<210>  3
<211>  777
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FRET-based glucose-detection molecule D278

<400>  3

Val Ser Glu Leu Ile Lys Glu Asn Met His Met Lys Leu Tyr Met Glu 
1               5                   10                  15      


Gly Thr Val Asn Asn His His Phe Lys Cys Thr Ser Glu Gly Glu Gly 
            20                  25                  30          


Lys Pro Tyr Glu Gly Thr Gln Thr Met Arg Ile Lys Ala Val Glu Gly 
        35                  40                  45              


Gly Pro Leu Pro Phe Ala Phe Asp Ile Leu Ala Thr Ser Phe Met Tyr 
    50                  55                  60                  


Gly Ser Lys Thr Phe Ile Asn His Thr Gln Gly Ile Pro Asp Phe Phe 
65                  70                  75                  80  


Lys Gln Ser Phe Pro Glu Gly Phe Thr Trp Glu Arg Val Thr Thr Tyr 
                85                  90                  95      


Glu Asp Gly Gly Val Leu Thr Ala Thr Gln Asp Thr Ser Leu Gln Asp 
            100                 105                 110         


Gly Cys Leu Ile Tyr Asn Val Lys Ile Arg Gly Val Asn Phe Pro Ser 
        115                 120                 125             


Asn Gly Pro Val Met Gln Lys Lys Thr Leu Gly Trp Glu Ala Ser Thr 
    130                 135                 140                 


Glu Thr Leu Tyr Pro Ala Asp Gly Gly Leu Glu Gly Arg Ala Asp Met 
145                 150                 155                 160 


Ala Leu Lys Leu Val Gly Gly Gly His Leu Ile Cys Asn Leu Lys Thr 
                165                 170                 175     


Thr Tyr Arg Ser Lys Lys Pro Ala Lys Asn Leu Lys Met Pro Gly Val 
            180                 185                 190         


Tyr Tyr Val Asp Arg Arg Leu Glu Arg Ile Lys Glu Ala Asp Lys Glu 
        195                 200                 205             


Thr Tyr Val Glu Gln His Glu Val Ala Val Ala Arg Tyr Cys Asp Leu 
    210                 215                 220                 


Pro Ser Lys Leu Gly His Lys Leu Asn Gly Met Asp Glu Ala Asp Thr 
225                 230                 235                 240 


Arg Ile Gly Val Thr Ile Tyr Lys Tyr Asp Asp Asn Gln Met Ser Val 
                245                 250                 255     


Val Arg Lys Ala Ile Glu Gln Asp Ala Lys Ala Ala Pro Asp Val Gln 
            260                 265                 270         


Leu Leu Met Asn Asp Ser Gln Asn Asp Gln Ser Lys Gln Asn Asp Gln 
        275                 280                 285             


Ile Asp Val Leu Leu Ala Lys Gly Val Lys Ala Leu Ala Ile Asn Leu 
    290                 295                 300                 


Val Asp Pro Ala Ala Ala Gly Thr Val Ile Glu Lys Ala Arg Gly Gln 
305                 310                 315                 320 


Asn Val Pro Val Val Phe Phe Asn Lys Glu Pro Ser Arg Lys Ala Leu 
                325                 330                 335     


Asp Ser Tyr Asp Lys Ala Tyr Tyr Val Gly Thr Asp Ser Lys Glu Ser 
            340                 345                 350         


Gly Ile Ile Gln Gly Asp Leu Ile Ala Lys His Trp Ala Ala Asn Gln 
        355                 360                 365             


Gly Trp Asp Leu Asn Lys Asp Gly Gln Ile Gln Phe Val Leu Leu Lys 
    370                 375                 380                 


Gly Glu Pro Gly His Pro Asp Ala Glu Ala Arg Thr Thr Tyr Val Ile 
385                 390                 395                 400 


Lys Glu Leu Asn Asp Lys Gly Ile Lys Thr Glu Gln Leu Gln Leu Asp 
                405                 410                 415     


Thr Ala Met Trp Asp Thr Ala Gln Ala Lys Asp Lys Met Asp Ala Trp 
            420                 425                 430         


Leu Ser Gly Pro Asn Ala Asn Lys Ile Glu Val Val Ile Ala Asn Asn 
        435                 440                 445             


Asp Ala Met Ala Met Gly Ala Val Glu Ala Leu Lys Ala His Asn Lys 
    450                 455                 460                 


Ser Ser Ile Pro Val Phe Gly Val Asp Ala Leu Pro Glu Ala Leu Ala 
465                 470                 475                 480 


Leu Val Lys Ser Gly Ala Leu Ala Gly Thr Val Leu Asn Asp Ala Asn 
                485                 490                 495     


Asn Gln Ala Lys Ala Thr Phe Asp Leu Ala Lys Asn Leu Ala Asp Ser 
            500                 505                 510         


Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val Glu Leu 
        515                 520                 525             


Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Arg Gly Glu Gly Glu 
    530                 535                 540                 


Gly Asp Ala Thr Asn Gly Lys Leu Thr Leu Lys Phe Ile Cys Thr Thr 
545                 550                 555                 560 


Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr Phe Gly Tyr 
                565                 570                 575     


Gly Val Ala Cys Phe Ser Arg Tyr Pro Asp His Met Lys Gln His Asp 
            580                 585                 590         


Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile 
        595                 600                 605             


Ser Phe Lys Asp Asp Gly Thr Tyr Lys Thr Arg Ala Glu Val Lys Phe 
    610                 615                 620                 


Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe 
625                 630                 635                 640 


Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr Asn Phe Asn 
                645                 650                 655     


Ser His Asn Val Tyr Ile Thr Ala Asp Lys Gln Lys Asn Gly Ile Lys 
            660                 665                 670         


Ala Asn Phe Lys Ile Arg His Asn Val Glu Asp Gly Ser Val Gln Leu 
        675                 680                 685             


Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Leu 
    690                 695                 700                 


Leu Pro Asp Asn His Tyr Leu Ser His Gln Ser Ala Leu Ser Lys Asp 
705                 710                 715                 720 


Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe Val Thr Ala 
                725                 730                 735     


Ala Gly Ile Thr His Gly Met Asp Gly Ala Ala Asp Gly Thr Asn Trp 
            740                 745                 750         


Lys Ile Asp Asn Lys Val Val Arg Val Pro Tyr Val Gly Val Asp Lys 
        755                 760                 765             


Asp Asn Leu Ala Glu Phe Ser Lys Lys 
    770                 775         


<210>  4
<211>  769
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FRET-based glucose-detection molecule D279

<400>  4

Val Ser Glu Leu Ile Lys Glu Asn Met His Met Lys Leu Tyr Met Glu 
1               5                   10                  15      


Gly Thr Val Asn Asn His His Phe Lys Cys Thr Ser Glu Gly Glu Gly 
            20                  25                  30          


Lys Pro Tyr Glu Gly Thr Gln Thr Met Arg Ile Lys Ala Val Glu Gly 
        35                  40                  45              


Gly Pro Leu Pro Phe Ala Phe Asp Ile Leu Ala Thr Ser Phe Met Tyr 
    50                  55                  60                  


Gly Ser Lys Thr Phe Ile Asn His Thr Gln Gly Ile Pro Asp Phe Phe 
65                  70                  75                  80  


Lys Gln Ser Phe Pro Glu Gly Phe Thr Trp Glu Arg Val Thr Thr Tyr 
                85                  90                  95      


Glu Asp Gly Gly Val Leu Thr Ala Thr Gln Asp Thr Ser Leu Gln Asp 
            100                 105                 110         


Gly Cys Leu Ile Tyr Asn Val Lys Ile Arg Gly Val Asn Phe Pro Ser 
        115                 120                 125             


Asn Gly Pro Val Met Gln Lys Lys Thr Leu Gly Trp Glu Ala Ser Thr 
    130                 135                 140                 


Glu Thr Leu Tyr Pro Ala Asp Gly Gly Leu Glu Gly Arg Ala Asp Met 
145                 150                 155                 160 


Ala Leu Lys Leu Val Gly Gly Gly His Leu Ile Cys Asn Leu Lys Thr 
                165                 170                 175     


Thr Tyr Arg Ser Lys Lys Pro Ala Lys Asn Leu Lys Met Pro Gly Val 
            180                 185                 190         


Tyr Tyr Val Asp Arg Arg Leu Glu Arg Ile Lys Glu Ala Asp Lys Glu 
        195                 200                 205             


Thr Tyr Val Glu Gln His Glu Val Ala Val Ala Arg Tyr Cys Asp Leu 
    210                 215                 220                 


Pro Ser Lys Leu Gly His Arg Ala Asp Thr Arg Ile Gly Val Thr Ile 
225                 230                 235                 240 


Tyr Lys Tyr Asp Asp Asn Gln Met Ser Val Val Arg Lys Ala Ile Glu 
                245                 250                 255     


Gln Asp Ala Lys Ala Ala Pro Asp Val Gln Leu Leu Met Asn Asp Ser 
            260                 265                 270         


Gln Asn Asp Gln Ser Lys Gln Asn Asp Gln Ile Asp Val Leu Leu Ala 
        275                 280                 285             


Lys Gly Val Lys Ala Leu Ala Ile Asn Leu Val Asp Pro Ala Ala Ala 
    290                 295                 300                 


Gly Thr Val Ile Glu Lys Ala Arg Gly Gln Asn Val Pro Val Val Phe 
305                 310                 315                 320 


Phe Asn Lys Glu Pro Ser Arg Lys Ala Leu Asp Ser Tyr Asp Lys Ala 
                325                 330                 335     


Tyr Tyr Val Gly Thr Asp Ser Lys Glu Ser Gly Ile Ile Gln Gly Asp 
            340                 345                 350         


Leu Ile Ala Lys His Trp Ala Ala Asn Gln Gly Trp Asp Leu Asn Lys 
        355                 360                 365             


Asp Gly Gln Ile Gln Phe Val Leu Leu Lys Gly Glu Pro Gly His Pro 
    370                 375                 380                 


Asp Ala Glu Ala Arg Thr Thr Tyr Val Ile Lys Glu Leu Asn Asp Lys 
385                 390                 395                 400 


Gly Ile Lys Thr Glu Gln Leu Gln Leu Asp Thr Ala Met Trp Asp Thr 
                405                 410                 415     


Ala Gln Ala Lys Asp Lys Met Asp Ala Trp Leu Ser Gly Pro Asn Ala 
            420                 425                 430         


Asn Lys Ile Glu Val Val Ile Ala Asn Asn Asp Ala Met Ala Met Gly 
        435                 440                 445             


Ala Val Glu Ala Leu Lys Ala His Asn Lys Ser Ser Ile Pro Val Phe 
    450                 455                 460                 


Gly Val Asp Ala Leu Pro Glu Ala Leu Ala Leu Val Lys Ser Gly Ala 
465                 470                 475                 480 


Leu Ala Gly Thr Val Leu Asn Asp Ala Asn Asn Gln Ala Lys Ala Thr 
                485                 490                 495     


Phe Asp Leu Ala Lys Asn Leu Ala Asp Gly Glu Glu Leu Phe Thr Gly 
            500                 505                 510         


Val Val Pro Ile Leu Val Glu Leu Asp Gly Asp Val Asn Gly His Lys 
        515                 520                 525             


Phe Ser Val Arg Gly Glu Gly Glu Gly Asp Ala Thr Asn Gly Lys Leu 
    530                 535                 540                 


Thr Leu Lys Phe Ile Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro 
545                 550                 555                 560 


Thr Leu Val Thr Thr Phe Gly Tyr Gly Val Ala Cys Phe Ser Arg Tyr 
                565                 570                 575     


Pro Asp His Met Lys Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu 
            580                 585                 590         


Gly Tyr Val Gln Glu Arg Thr Ile Ser Phe Lys Asp Asp Gly Thr Tyr 
        595                 600                 605             


Lys Thr Arg Ala Glu Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg 
    610                 615                 620                 


Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly 
625                 630                 635                 640 


His Lys Leu Glu Tyr Asn Phe Asn Ser His Asn Val Tyr Ile Thr Ala 
                645                 650                 655     


Asp Lys Gln Lys Asn Gly Ile Lys Ala Asn Phe Lys Ile Arg His Asn 
            660                 665                 670         


Val Glu Asp Gly Ser Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr 
        675                 680                 685             


Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser 
    690                 695                 700                 


His Gln Ser Ala Leu Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met 
705                 710                 715                 720 


Val Leu Leu Glu Phe Val Thr Ala Ala Gly Ile Thr His Gly Met Asp 
                725                 730                 735     


Gly Ala Ala Asp Gly Thr Asn Trp Lys Ile Asp Asn Lys Val Val Arg 
            740                 745                 750         


Val Pro Tyr Val Gly Val Asp Lys Asp Asn Leu Ala Glu Phe Ser Lys 
        755                 760                 765             


Lys 
    


<210>  5
<211>  786
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FRET-based glucose-detection molecule D137

<400>  5

Val Ser Lys Gly Glu Glu Leu Ile Lys Glu Asn Met His Thr Lys Leu 
1               5                   10                  15      


Tyr Met Glu Gly Thr Val Asn Asn His His Phe Lys Cys Thr His Glu 
            20                  25                  30          


Gly Glu Gly Lys Pro Tyr Glu Gly Thr Gln Thr Asn Arg Ile Lys Val 
        35                  40                  45              


Val Glu Gly Gly Pro Leu Pro Phe Ala Phe Asp Ile Leu Ala Thr Cys 
    50                  55                  60                  


Phe Met Tyr Gly Ser Lys Thr Phe Ile Asn His Thr Gln Gly Ile Pro 
65                  70                  75                  80  


Asp Phe Phe Lys Gln Ser Phe Pro Glu Gly Phe Thr Trp Glu Arg Val 
                85                  90                  95      


Thr Thr Tyr Glu Asp Gly Gly Val Leu Thr Val Thr Gln Asp Thr Ser 
            100                 105                 110         


Leu Gln Asp Gly Cys Leu Ile Tyr Asn Val Lys Leu Arg Gly Val Asn 
        115                 120                 125             


Phe Pro Ser Asn Gly Pro Val Met Gln Lys Lys Thr Leu Gly Trp Glu 
    130                 135                 140                 


Ala Ser Thr Glu Thr Leu Tyr Pro Ala Asp Gly Gly Leu Glu Gly Arg 
145                 150                 155                 160 


Cys Asp Met Ala Leu Lys Leu Val Gly Gly Gly His Leu His Cys Asn 
                165                 170                 175     


Leu Lys Thr Thr Tyr Arg Ser Lys Lys Pro Ala Lys Asn Leu Lys Met 
            180                 185                 190         


Pro Gly Val Tyr Phe Val Asp Arg Arg Leu Glu Arg Ile Lys Glu Ala 
        195                 200                 205             


Asp Asn Glu Thr Tyr Val Glu Gln His Glu Val Ala Val Ala Arg Tyr 
    210                 215                 220                 


Cys Asp Leu Pro Ser Lys Leu Gly His Lys Leu Asn Gly Met Asp Glu 
225                 230                 235                 240 


Ala Asp Thr Arg Ile Gly Val Thr Ile Tyr Lys Tyr Asp Asp Asn Ala 
                245                 250                 255     


Met Ser Val Val Arg Lys Ala Ile Glu Gln Asp Ala Lys Ala Ala Pro 
            260                 265                 270         


Asp Val Gln Leu Leu Met Asn Asp Ser Gln Asn Asp Gln Ser Lys Gln 
        275                 280                 285             


Asn Asp Gln Ile Asp Val Leu Leu Ala Lys Gly Val Lys Ala Leu Ala 
    290                 295                 300                 


Ile Asn Leu Val Asp Pro Ala Ala Ala Gly Thr Val Ile Glu Lys Ala 
305                 310                 315                 320 


Arg Gly Gln Asn Val Pro Val Val Phe Phe Asn Lys Glu Pro Ser Arg 
                325                 330                 335     


Lys Ala Leu Asp Ser Tyr Asp Lys Ala Tyr Tyr Val Gly Thr Asp Ser 
            340                 345                 350         


Lys Glu Ser Gly Ile Ile Gln Gly Asp Leu Ile Ala Lys His Trp Ala 
        355                 360                 365             


Ala Asn Gln Gly Trp Asp Leu Asn Lys Asp Gly Gln Ile Gln Phe Val 
    370                 375                 380                 


Leu Leu Lys Gly Glu Pro Gly His Pro Asp Ala Glu Ala Arg Thr Thr 
385                 390                 395                 400 


Tyr Val Ile Lys Glu Leu Asn Asp Lys Gly Ile Lys Thr Glu Gln Leu 
                405                 410                 415     


Gln Leu Asp Thr Ala Met Trp Asp Thr Ala Gln Ala Lys Asp Lys Met 
            420                 425                 430         


Asp Ala Trp Leu Ser Gly Pro Asn Ala Asn Lys Ile Glu Val Val Ile 
        435                 440                 445             


Ala Asn Asn Asp Ala Met Ala Met Gly Ala Val Glu Ala Leu Lys Ala 
    450                 455                 460                 


His Asn Lys Ser Ser Ile Pro Val Phe Gly Val Asp Ala Leu Pro Glu 
465                 470                 475                 480 


Ala Leu Ala Leu Val Lys Ser Gly Ala Leu Ala Gly Thr Val Leu Asn 
                485                 490                 495     


Asp Ala Asn Asn Gln Ala Lys Ala Thr Phe Asp Leu Ala Lys Asn Leu 
            500                 505                 510         


Ala Asp Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro 
        515                 520                 525             


Ile Leu Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val 
    530                 535                 540                 


Arg Gly Glu Gly Glu Gly Asp Ala Thr Asn Gly Lys Leu Thr Leu Lys 
545                 550                 555                 560 


Phe Ile Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val 
                565                 570                 575     


Thr Thr Phe Gly Tyr Gly Val Ala Cys Phe Ser Arg Tyr Pro Asp His 
            580                 585                 590         


Met Lys Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val 
        595                 600                 605             


Gln Glu Arg Thr Ile Ser Phe Lys Asp Asp Gly Thr Tyr Lys Thr Arg 
    610                 615                 620                 


Ala Glu Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu 
625                 630                 635                 640 


Lys Gly Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu 
                645                 650                 655     


Glu Tyr Asn Phe Asn Ser His Asn Val Tyr Ile Thr Ala Asp Lys Gln 
            660                 665                 670         


Lys Asn Gly Ile Lys Ala Asn Phe Lys Ile Arg His Asn Val Glu Asp 
        675                 680                 685             


Gly Ser Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly 
    690                 695                 700                 


Asp Gly Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser His Gln Ser 
705                 710                 715                 720 


Ala Leu Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu 
                725                 730                 735     


Glu Phe Val Thr Ala Ala Gly Ile Thr His Gly Met Asp Glu Leu Tyr 
            740                 745                 750         


Lys Gly Ala Ala Asp Gly Thr Asn Trp Lys Ile Asp Asn Lys Val Val 
        755                 760                 765             


Arg Val Pro Tyr Val Gly Val Asp Lys Asp Asn Leu Ala Glu Phe Ser 
    770                 775                 780                 


Lys Lys 
785     


<210>  6
<211>  782
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FRET-based glucose-detection molecule D138

<400>  6

Val Ser Lys Gly Glu Glu Leu Ile Lys Glu Asn Met His Thr Lys Leu 
1               5                   10                  15      


Tyr Met Glu Gly Thr Val Asn Asn His His Phe Lys Cys Thr His Glu 
            20                  25                  30          


Gly Glu Gly Lys Pro Tyr Glu Gly Thr Gln Thr Asn Arg Ile Lys Val 
        35                  40                  45              


Val Glu Gly Gly Pro Leu Pro Phe Ala Phe Asp Ile Leu Ala Thr Cys 
    50                  55                  60                  


Phe Met Tyr Gly Ser Lys Thr Phe Ile Asn His Thr Gln Gly Ile Pro 
65                  70                  75                  80  


Asp Phe Phe Lys Gln Ser Phe Pro Glu Gly Phe Thr Trp Glu Arg Val 
                85                  90                  95      


Thr Thr Tyr Glu Asp Gly Gly Val Leu Thr Val Thr Gln Asp Thr Ser 
            100                 105                 110         


Leu Gln Asp Gly Cys Leu Ile Tyr Asn Val Lys Leu Arg Gly Val Asn 
        115                 120                 125             


Phe Pro Ser Asn Gly Pro Val Met Gln Lys Lys Thr Leu Gly Trp Glu 
    130                 135                 140                 


Ala Ser Thr Glu Thr Leu Tyr Pro Ala Asp Gly Gly Leu Glu Gly Arg 
145                 150                 155                 160 


Cys Asp Met Ala Leu Lys Leu Val Gly Gly Gly His Leu His Cys Asn 
                165                 170                 175     


Leu Lys Thr Thr Tyr Arg Ser Lys Lys Pro Ala Lys Asn Leu Lys Met 
            180                 185                 190         


Pro Gly Val Tyr Phe Val Asp Arg Arg Leu Glu Arg Ile Lys Glu Ala 
        195                 200                 205             


Asp Asn Glu Thr Tyr Val Glu Gln His Glu Val Ala Val Ala Arg Tyr 
    210                 215                 220                 


Cys Asp Leu Pro Ser Lys Leu Gly His Lys Leu Asn Gly Met Asp Glu 
225                 230                 235                 240 


Ala Asp Thr Arg Ile Gly Val Thr Ile Tyr Lys Tyr Asp Asp Asn Ala 
                245                 250                 255     


Met Ser Val Val Arg Lys Ala Ile Glu Gln Asp Ala Lys Ala Ala Pro 
            260                 265                 270         


Asp Val Gln Leu Leu Met Asn Asp Ser Gln Asn Asp Gln Ser Lys Gln 
        275                 280                 285             


Asn Asp Gln Ile Asp Val Leu Leu Ala Lys Gly Val Lys Ala Leu Ala 
    290                 295                 300                 


Ile Asn Leu Val Asp Pro Ala Ala Ala Gly Thr Val Ile Glu Lys Ala 
305                 310                 315                 320 


Arg Gly Gln Asn Val Pro Val Val Phe Phe Asn Lys Glu Pro Ser Arg 
                325                 330                 335     


Lys Ala Leu Asp Ser Tyr Asp Lys Ala Tyr Tyr Val Gly Thr Asp Ser 
            340                 345                 350         


Lys Glu Ser Gly Ile Ile Gln Gly Asp Leu Ile Ala Lys His Trp Ala 
        355                 360                 365             


Ala Asn Gln Gly Trp Asp Leu Asn Lys Asp Gly Gln Ile Gln Phe Val 
    370                 375                 380                 


Leu Leu Lys Gly Glu Pro Gly His Pro Asp Ala Glu Ala Arg Thr Thr 
385                 390                 395                 400 


Tyr Val Ile Lys Glu Leu Asn Asp Lys Gly Ile Lys Thr Glu Gln Leu 
                405                 410                 415     


Gln Leu Asp Thr Ala Met Trp Asp Thr Ala Gln Ala Lys Asp Lys Met 
            420                 425                 430         


Asp Ala Trp Leu Ser Gly Pro Asn Ala Asn Lys Ile Glu Val Val Ile 
        435                 440                 445             


Ala Asn Asn Asp Ala Met Ala Met Gly Ala Val Glu Ala Leu Lys Ala 
    450                 455                 460                 


His Asn Lys Ser Ser Ile Pro Val Phe Gly Val Asp Ala Leu Pro Glu 
465                 470                 475                 480 


Ala Leu Ala Leu Val Lys Ser Gly Ala Leu Ala Gly Thr Val Leu Asn 
                485                 490                 495     


Asp Ala Asn Asn Gln Ala Lys Ala Thr Phe Asp Leu Ala Lys Asn Leu 
            500                 505                 510         


Ala Asp Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro 
        515                 520                 525             


Ile Leu Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val 
    530                 535                 540                 


Arg Gly Glu Gly Glu Gly Asp Ala Thr Asn Gly Lys Leu Thr Leu Lys 
545                 550                 555                 560 


Phe Ile Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val 
                565                 570                 575     


Thr Thr Phe Gly Tyr Gly Val Ala Cys Phe Ser Arg Tyr Pro Asp His 
            580                 585                 590         


Met Lys Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val 
        595                 600                 605             


Gln Glu Arg Thr Ile Ser Phe Lys Asp Asp Gly Thr Tyr Lys Thr Arg 
    610                 615                 620                 


Ala Glu Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu 
625                 630                 635                 640 


Lys Gly Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu 
                645                 650                 655     


Glu Tyr Asn Phe Asn Ser His Asn Val Tyr Ile Thr Ala Asp Lys Gln 
            660                 665                 670         


Lys Asn Gly Ile Lys Ala Asn Phe Lys Ile Arg His Asn Val Glu Asp 
        675                 680                 685             


Gly Ser Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly 
    690                 695                 700                 


Asp Gly Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser His Gln Ser 
705                 710                 715                 720 


Ala Leu Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu 
                725                 730                 735     


Glu Phe Val Thr Ala Ala Gly Ile Thr His Gly Met Asp Gly Ala Ala 
            740                 745                 750         


Asp Gly Thr Asn Trp Lys Ile Asp Asn Lys Val Val Arg Val Pro Tyr 
        755                 760                 765             


Val Gly Val Asp Lys Asp Asn Leu Ala Glu Phe Ser Lys Lys 
    770                 775                 780         


<210>  7
<211>  231
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Acceptor-fluorophore amino acid sequence 66


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa can be Gly or Val

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa can be Glu or Ser

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa can be Thr or Met

<220>
<221>  MISC_FEATURE
<222>  (28)..(28)
<223>  Xaa can be His or Ser

<220>
<221>  MISC_FEATURE
<222>  (41)..(41)
<223>  Xaa can be Asn or Met

<220>
<221>  MISC_FEATURE
<222>  (45)..(45)
<223>  Xaa can be Val or Ala

<220>
<221>  MISC_FEATURE
<222>  (61)..(61)
<223>  Xaa can be Cys or Ser

<220>
<221>  MISC_FEATURE
<222>  (104)..(104)
<223>  Xaa can be Val or Ala

<220>
<221>  MISC_FEATURE
<222>  (121)..(121)
<223>  Xaa can be Leu or Ile

<220>
<221>  MISC_FEATURE
<222>  (158)..(158)
<223>  Xaa can be Cys or Ala

<220>
<221>  MISC_FEATURE
<222>  (171)..(171)
<223>  Xaa can be His or Ile

<220>
<221>  MISC_FEATURE
<222>  (194)..(194)
<223>  Xaa can be Phe or Tyr

<220>
<221>  MISC_FEATURE
<222>  (207)..(207)
<223>  Xaa can be Asn or Lys

<220>
<221>  MISC_FEATURE
<222>  (231)..(231)
<223>  Xaa can be Lys or Arg

<400>  7

Xaa Xaa Glu Leu Ile Lys Glu Asn Met His Xaa Lys Leu Tyr Met Glu 
1               5                   10                  15      


Gly Thr Val Asn Asn His His Phe Lys Cys Thr Xaa Glu Gly Glu Gly 
            20                  25                  30          


Lys Pro Tyr Glu Gly Thr Gln Thr Xaa Arg Ile Lys Xaa Val Glu Gly 
        35                  40                  45              


Gly Pro Leu Pro Phe Ala Phe Asp Ile Leu Ala Thr Xaa Phe Met Tyr 
    50                  55                  60                  


Gly Ser Lys Thr Phe Ile Asn His Thr Gln Gly Ile Pro Asp Phe Phe 
65                  70                  75                  80  


Lys Gln Ser Phe Pro Glu Gly Phe Thr Trp Glu Arg Val Thr Thr Tyr 
                85                  90                  95      


Glu Asp Gly Gly Val Leu Thr Xaa Thr Gln Asp Thr Ser Leu Gln Asp 
            100                 105                 110         


Gly Cys Leu Ile Tyr Asn Val Lys Xaa Arg Gly Val Asn Phe Pro Ser 
        115                 120                 125             


Asn Gly Pro Val Met Gln Lys Lys Thr Leu Gly Trp Glu Ala Ser Thr 
    130                 135                 140                 


Glu Thr Leu Tyr Pro Ala Asp Gly Gly Leu Glu Gly Arg Xaa Asp Met 
145                 150                 155                 160 


Ala Leu Lys Leu Val Gly Gly Gly His Leu Xaa Cys Asn Leu Lys Thr 
                165                 170                 175     


Thr Tyr Arg Ser Lys Lys Pro Ala Lys Asn Leu Lys Met Pro Gly Val 
            180                 185                 190         


Tyr Xaa Val Asp Arg Arg Leu Glu Arg Ile Lys Glu Ala Asp Xaa Glu 
        195                 200                 205             


Thr Tyr Val Glu Gln His Glu Val Ala Val Ala Arg Tyr Cys Asp Leu 
    210                 215                 220                 


Pro Ser Lys Leu Gly His Xaa 
225                 230     


<210>  8
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker sequence 72

<400>  8

Leu Asn Gly Met Asp Glu 
1               5       


<210>  9
<211>  274
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Glucose-binding-region sequence 62a


<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa can be a hydrophillic or an amidic amino acid (e.g., Gln or 
       Asn), or can be Ala or Val

<400>  9

Ala Asp Thr Arg Ile Gly Val Thr Ile Tyr Lys Tyr Asp Asp Asn Xaa 
1               5                   10                  15      


Met Ser Val Val Arg Lys Ala Ile Glu Gln Asp Ala Lys Ala Ala Pro 
            20                  25                  30          


Asp Val Gln Leu Leu Met Asn Asp Ser Gln Asn Asp Gln Ser Lys Gln 
        35                  40                  45              


Asn Asp Gln Ile Asp Val Leu Leu Ala Lys Gly Val Lys Ala Leu Ala 
    50                  55                  60                  


Ile Asn Leu Val Asp Pro Ala Ala Ala Gly Thr Val Ile Glu Lys Ala 
65                  70                  75                  80  


Arg Gly Gln Asn Val Pro Val Val Phe Phe Asn Lys Glu Pro Ser Arg 
                85                  90                  95      


Lys Ala Leu Asp Ser Tyr Asp Lys Ala Tyr Tyr Val Gly Thr Asp Ser 
            100                 105                 110         


Lys Glu Ser Gly Ile Ile Gln Gly Asp Leu Ile Ala Lys His Trp Ala 
        115                 120                 125             


Ala Asn Gln Gly Trp Asp Leu Asn Lys Asp Gly Gln Ile Gln Phe Val 
    130                 135                 140                 


Leu Leu Lys Gly Glu Pro Gly His Pro Asp Ala Glu Ala Arg Thr Thr 
145                 150                 155                 160 


Tyr Val Ile Lys Glu Leu Asn Asp Lys Gly Ile Lys Thr Glu Gln Leu 
                165                 170                 175     


Gln Leu Asp Thr Ala Met Trp Asp Thr Ala Gln Ala Lys Asp Lys Met 
            180                 185                 190         


Asp Ala Trp Leu Ser Gly Pro Asn Ala Asn Lys Ile Glu Val Val Ile 
        195                 200                 205             


Ala Asn Asn Asp Ala Met Ala Met Gly Ala Val Glu Ala Leu Lys Ala 
    210                 215                 220                 


His Asn Lys Ser Ser Ile Pro Val Phe Gly Val Asp Ala Leu Pro Glu 
225                 230                 235                 240 


Ala Leu Ala Leu Val Lys Ser Gly Ala Leu Ala Gly Thr Val Leu Asn 
                245                 250                 255     


Asp Ala Asn Asn Gln Ala Lys Ala Thr Phe Asp Leu Ala Lys Asn Leu 
            260                 265                 270         


Ala Asp 
        


<210>  10
<211>  231
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Donor-fluorophore amino acid sequence 64

<400>  10

Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val Glu Leu Asp 
1               5                   10                  15      


Gly Asp Val Asn Gly His Lys Phe Ser Val Arg Gly Glu Gly Glu Gly 
            20                  25                  30          


Asp Ala Thr Asn Gly Lys Leu Thr Leu Lys Phe Ile Cys Thr Thr Gly 
        35                  40                  45              


Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr Phe Gly Tyr Gly 
    50                  55                  60                  


Val Ala Cys Phe Ser Arg Tyr Pro Asp His Met Lys Gln His Asp Phe 
65                  70                  75                  80  


Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile Ser 
                85                  90                  95      


Phe Lys Asp Asp Gly Thr Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu 
            100                 105                 110         


Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys 
        115                 120                 125             


Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr Asn Phe Asn Ser 
    130                 135                 140                 


His Asn Val Tyr Ile Thr Ala Asp Lys Gln Lys Asn Gly Ile Lys Ala 
145                 150                 155                 160 


Asn Phe Lys Ile Arg His Asn Val Glu Asp Gly Ser Val Gln Leu Ala 
                165                 170                 175     


Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu 
            180                 185                 190         


Pro Asp Asn His Tyr Leu Ser His Gln Ser Ala Leu Ser Lys Asp Pro 
        195                 200                 205             


Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe Val Thr Ala Ala 
    210                 215                 220                 


Gly Ile Thr His Gly Met Asp 
225                 230     


<210>  11
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Glucose-binding-region sequence 62b

<400>  11

Gly Ala Ala Asp Gly Thr Asn Trp Lys Ile Asp Asn Lys Val Val Arg 
1               5                   10                  15      


Val Pro Tyr Val Gly Val Asp Lys Asp Asn Leu Ala Glu Phe Ser Lys 
            20                  25                  30          


Lys 
    


<210>  12
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  signal peptide

<400>  12

Met Trp Trp Arg Leu Trp Trp Leu Leu Leu Leu Leu Leu Leu Leu Trp 
1               5                   10                  15      


Pro Met Val Trp Ala 
            20      


