                         SEQUENCE LISTING

<110>  ECOLE NORMALE SUPERIEURE DE LYON (ENS LYON)
       CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)
       Universit Claude Bernard Lyon 1 (UCBL)
       INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE 
       (INSERM)
 
<120>  METHODS FOR SELECTIVELY MODULATING THE ACTIVITY OF DISTINCT 
       SUBTYPES OF CELLS

<130>  BET 17L1339

<150>  EP16305468.7
<151>  2016-04-21

<160>  16    

<170>  PatentIn version 3.5

<210>  1
<211>  2217
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Truncated and mutated (Y481A, R533A, S548L, F549S) MV H protein 
       (HcDelta18) fused to Designed Ankyrin Repeat Protein 
       (DARPin)-29.2 specific for human CD4


<220>
<221>  CDS
<222>  (1)..(2217)

<400>  1
atg gga agt agg ata gtc att aac aga gaa cat ctt atg att gat aga         48
Met Gly Ser Arg Ile Val Ile Asn Arg Glu His Leu Met Ile Asp Arg           
1               5                   10                  15                

cct tat gtt ttg ctg gct gtt ctg ttt gtc atg ttt ctg agc ttg atc         96
Pro Tyr Val Leu Leu Ala Val Leu Phe Val Met Phe Leu Ser Leu Ile           
            20                  25                  30                    

ggg ttg cta gcc att gca gga att cga ctt cat cgg gca gcc atc tac        144
Gly Leu Leu Ala Ile Ala Gly Ile Arg Leu His Arg Ala Ala Ile Tyr           
        35                  40                  45                        

acc gca gag atc cat aaa agc ctc agc acc aat cta gat gta act aac        192
Thr Ala Glu Ile His Lys Ser Leu Ser Thr Asn Leu Asp Val Thr Asn           
    50                  55                  60                            

tca atc gag cat cag gtc aag gac gtg ctg aca cca ctc ttc aaa atc        240
Ser Ile Glu His Gln Val Lys Asp Val Leu Thr Pro Leu Phe Lys Ile           
65                  70                  75                  80            

atc ggt gat gaa gtg ggc ctg agg aca cct cag aga ttc act gac cta        288
Ile Gly Asp Glu Val Gly Leu Arg Thr Pro Gln Arg Phe Thr Asp Leu           
                85                  90                  95                

gtg aaa ttc atc tct gac aag att aaa ttc ctt aat ccg gat agg gag        336
Val Lys Phe Ile Ser Asp Lys Ile Lys Phe Leu Asn Pro Asp Arg Glu           
            100                 105                 110                   

tac gac ttc aga gat ctc act tgg tgt atc aac ccg cca gag aga atc        384
Tyr Asp Phe Arg Asp Leu Thr Trp Cys Ile Asn Pro Pro Glu Arg Ile           
        115                 120                 125                       

aaa ttg gat tat gat caa tac tgt gca gat gtg gct gct gaa gag ctc        432
Lys Leu Asp Tyr Asp Gln Tyr Cys Ala Asp Val Ala Ala Glu Glu Leu           
    130                 135                 140                           

atg aat gca ttg gtg aac tca act cta ctg gag acc aga aca acc aat        480
Met Asn Ala Leu Val Asn Ser Thr Leu Leu Glu Thr Arg Thr Thr Asn           
145                 150                 155                 160           

cag ttc cta gct gtc tca aag gga aac tgc tca ggg ccc act aca atc        528
Gln Phe Leu Ala Val Ser Lys Gly Asn Cys Ser Gly Pro Thr Thr Ile           
                165                 170                 175               

aga ggt caa ttc tca aac atg tcg ctg tcc ctg tta gac ttg tat tta        576
Arg Gly Gln Phe Ser Asn Met Ser Leu Ser Leu Leu Asp Leu Tyr Leu           
            180                 185                 190                   

ggt cga ggt tac aat gtg tca tct ata gtc act atg aca tcc cag gga        624
Gly Arg Gly Tyr Asn Val Ser Ser Ile Val Thr Met Thr Ser Gln Gly           
        195                 200                 205                       

atg tat ggg gga act tac cta gtg gaa aag cct aat ctg agc agc aaa        672
Met Tyr Gly Gly Thr Tyr Leu Val Glu Lys Pro Asn Leu Ser Ser Lys           
    210                 215                 220                           

agg tca gag ttg tca caa ctg agc atg tac cga gtg ttt gaa gta ggt        720
Arg Ser Glu Leu Ser Gln Leu Ser Met Tyr Arg Val Phe Glu Val Gly           
225                 230                 235                 240           

gtt atc aga aat ccg ggt ttg ggg gct ccg gtg ttc cat atg aca aac        768
Val Ile Arg Asn Pro Gly Leu Gly Ala Pro Val Phe His Met Thr Asn           
                245                 250                 255               

tat ctt gag caa cca gtc agt aat gat ctc agc aac tgt atg gtg gct        816
Tyr Leu Glu Gln Pro Val Ser Asn Asp Leu Ser Asn Cys Met Val Ala           
            260                 265                 270                   

ttg ggg gag ctc aaa ctc gca gcc ctt tgt cac ggg gaa gat tct atc        864
Leu Gly Glu Leu Lys Leu Ala Ala Leu Cys His Gly Glu Asp Ser Ile           
        275                 280                 285                       

aca att ccc tat cag gga tca ggg aaa ggt gtc agc ttc cag ctc gtc        912
Thr Ile Pro Tyr Gln Gly Ser Gly Lys Gly Val Ser Phe Gln Leu Val           
    290                 295                 300                           

aag cta ggt gtc tgg aaa tcc cca acc gac atg caa tcc tgg gtc ccc        960
Lys Leu Gly Val Trp Lys Ser Pro Thr Asp Met Gln Ser Trp Val Pro           
305                 310                 315                 320           

tta tca acg gat gat cca gtg ata gac agg ctt tac ctc tca tct cac       1008
Leu Ser Thr Asp Asp Pro Val Ile Asp Arg Leu Tyr Leu Ser Ser His           
                325                 330                 335               

aga ggt gtt atc gct gac aac caa gca aaa tgg gct gtc ccg aca aca       1056
Arg Gly Val Ile Ala Asp Asn Gln Ala Lys Trp Ala Val Pro Thr Thr           
            340                 345                 350                   

cga aca gat gac aag ttg cga atg gag aca tgc ttc caa cag gcg tgt       1104
Arg Thr Asp Asp Lys Leu Arg Met Glu Thr Cys Phe Gln Gln Ala Cys           
        355                 360                 365                       

aag ggt aaa atc caa gca ctc tgc gag aat ccc gag tgg gca cca ttg       1152
Lys Gly Lys Ile Gln Ala Leu Cys Glu Asn Pro Glu Trp Ala Pro Leu           
    370                 375                 380                           

aag gat aac agg att cct tca tac ggg gtc ttg tct gtt gat ctg agt       1200
Lys Asp Asn Arg Ile Pro Ser Tyr Gly Val Leu Ser Val Asp Leu Ser           
385                 390                 395                 400           

ctg aca gtt gag ctt aaa atc aaa att gct tcg gga ttc ggg cca ttg       1248
Leu Thr Val Glu Leu Lys Ile Lys Ile Ala Ser Gly Phe Gly Pro Leu           
                405                 410                 415               

atc aca cac ggt tca ggg atg gac cta tac aaa tcc aac cac aac aat       1296
Ile Thr His Gly Ser Gly Met Asp Leu Tyr Lys Ser Asn His Asn Asn           
            420                 425                 430                   

gtg tat tgg ctg act atc ccg cca atg aag aac cta gcc tta ggt gta       1344
Val Tyr Trp Leu Thr Ile Pro Pro Met Lys Asn Leu Ala Leu Gly Val           
        435                 440                 445                       

atc aac aca ttg gag tgg ata ccg aga ttc aag gtt agt ccc gca ctc       1392
Ile Asn Thr Leu Glu Trp Ile Pro Arg Phe Lys Val Ser Pro Ala Leu           
    450                 455                 460                           

ttc act gtc cca att aag gaa gca ggc gga gac tgc cat gcc cca aca       1440
Phe Thr Val Pro Ile Lys Glu Ala Gly Gly Asp Cys His Ala Pro Thr           
465                 470                 475                 480           

tac cta cct gcg gag gtg gat ggt gat gtc aaa ctc agt tcc aat ctg       1488
Tyr Leu Pro Ala Glu Val Asp Gly Asp Val Lys Leu Ser Ser Asn Leu           
                485                 490                 495               

gtg att cta cct ggt caa gat ctc caa tat gtt ttg gca acc tac gat       1536
Val Ile Leu Pro Gly Gln Asp Leu Gln Tyr Val Leu Ala Thr Tyr Asp           
            500                 505                 510                   

act tcc gcg gtt gaa cat gct gtg gtt tat tac gtt tac agc cca agc       1584
Thr Ser Ala Val Glu His Ala Val Val Tyr Tyr Val Tyr Ser Pro Ser           
        515                 520                 525                       

cgc cta tcg tct tac ttt tat cct ttt agg ttg cct ata aag ggg gtc       1632
Arg Leu Ser Ser Tyr Phe Tyr Pro Phe Arg Leu Pro Ile Lys Gly Val           
    530                 535                 540                           

ccc atc gaa tta caa gtg gaa tgc ttc aca tgg gac caa aaa ctc tgg       1680
Pro Ile Glu Leu Gln Val Glu Cys Phe Thr Trp Asp Gln Lys Leu Trp           
545                 550                 555                 560           

tgc cgt cac ttc tgt gtg ctt gcg gac tca gaa tct ggt gga cat atc       1728
Cys Arg His Phe Cys Val Leu Ala Asp Ser Glu Ser Gly Gly His Ile           
                565                 570                 575               

act cac tct ggg atg gtg ggc atg gga gtc agc tgc aca gtc acc cgg       1776
Thr His Ser Gly Met Val Gly Met Gly Val Ser Cys Thr Val Thr Arg           
            580                 585                 590                   

gaa gat gga acc aat gcg gcc cag ccg gcc gac ctg ggt aag aaa ctg       1824
Glu Asp Gly Thr Asn Ala Ala Gln Pro Ala Asp Leu Gly Lys Lys Leu           
        595                 600                 605                       

ctg gaa gct gct cgt gct ggt cag gac gac gaa gtt cgt atc ctg atg       1872
Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp Glu Val Arg Ile Leu Met           
    610                 615                 620                           

gct aac ggt gct gac gtt aac gct act gac act ctt ggt cgt act ccg       1920
Ala Asn Gly Ala Asp Val Asn Ala Thr Asp Thr Leu Gly Arg Thr Pro           
625                 630                 635                 640           

cta cac ctg gct gct cag aat ggt cac ctg gaa atc gtt gaa gtt ctg       1968
Leu His Leu Ala Ala Gln Asn Gly His Leu Glu Ile Val Glu Val Leu           
                645                 650                 655               

ctg aag cac agt gct gac gtt aac gct att gaa gag gtt ggt atg act       2016
Leu Lys His Ser Ala Asp Val Asn Ala Ile Glu Glu Val Gly Met Thr           
            660                 665                 670                   

ccg ctg cac ctg gct gtt gtt gct ggt cac ctg gaa atc gtt gaa gtt       2064
Pro Leu His Leu Ala Val Val Ala Gly His Leu Glu Ile Val Glu Val           
        675                 680                 685                       

ctg ctg aag aac ggt gct gac gtt aac gct cag gac aaa ttc ggt aag       2112
Leu Leu Lys Asn Gly Ala Asp Val Asn Ala Gln Asp Lys Phe Gly Lys           
    690                 695                 700                           

acc gct ttc gac atc tcc atc gac tac ggt aac gag gac ctg gct gaa       2160
Thr Ala Phe Asp Ile Ser Ile Asp Tyr Gly Asn Glu Asp Leu Ala Glu           
705                 710                 715                 720           

atc ctg caa aag ctt aat gcg gcc gca aga ggt tct cat cac cat cac       2208
Ile Leu Gln Lys Leu Asn Ala Ala Ala Arg Gly Ser His His His His           
                725                 730                 735               

cat cac taa                                                           2217
His His                                                                   
                                                                          


<210>  2
<211>  738
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2

Met Gly Ser Arg Ile Val Ile Asn Arg Glu His Leu Met Ile Asp Arg 
1               5                   10                  15      


Pro Tyr Val Leu Leu Ala Val Leu Phe Val Met Phe Leu Ser Leu Ile 
            20                  25                  30          


Gly Leu Leu Ala Ile Ala Gly Ile Arg Leu His Arg Ala Ala Ile Tyr 
        35                  40                  45              


Thr Ala Glu Ile His Lys Ser Leu Ser Thr Asn Leu Asp Val Thr Asn 
    50                  55                  60                  


Ser Ile Glu His Gln Val Lys Asp Val Leu Thr Pro Leu Phe Lys Ile 
65                  70                  75                  80  


Ile Gly Asp Glu Val Gly Leu Arg Thr Pro Gln Arg Phe Thr Asp Leu 
                85                  90                  95      


Val Lys Phe Ile Ser Asp Lys Ile Lys Phe Leu Asn Pro Asp Arg Glu 
            100                 105                 110         


Tyr Asp Phe Arg Asp Leu Thr Trp Cys Ile Asn Pro Pro Glu Arg Ile 
        115                 120                 125             


Lys Leu Asp Tyr Asp Gln Tyr Cys Ala Asp Val Ala Ala Glu Glu Leu 
    130                 135                 140                 


Met Asn Ala Leu Val Asn Ser Thr Leu Leu Glu Thr Arg Thr Thr Asn 
145                 150                 155                 160 


Gln Phe Leu Ala Val Ser Lys Gly Asn Cys Ser Gly Pro Thr Thr Ile 
                165                 170                 175     


Arg Gly Gln Phe Ser Asn Met Ser Leu Ser Leu Leu Asp Leu Tyr Leu 
            180                 185                 190         


Gly Arg Gly Tyr Asn Val Ser Ser Ile Val Thr Met Thr Ser Gln Gly 
        195                 200                 205             


Met Tyr Gly Gly Thr Tyr Leu Val Glu Lys Pro Asn Leu Ser Ser Lys 
    210                 215                 220                 


Arg Ser Glu Leu Ser Gln Leu Ser Met Tyr Arg Val Phe Glu Val Gly 
225                 230                 235                 240 


Val Ile Arg Asn Pro Gly Leu Gly Ala Pro Val Phe His Met Thr Asn 
                245                 250                 255     


Tyr Leu Glu Gln Pro Val Ser Asn Asp Leu Ser Asn Cys Met Val Ala 
            260                 265                 270         


Leu Gly Glu Leu Lys Leu Ala Ala Leu Cys His Gly Glu Asp Ser Ile 
        275                 280                 285             


Thr Ile Pro Tyr Gln Gly Ser Gly Lys Gly Val Ser Phe Gln Leu Val 
    290                 295                 300                 


Lys Leu Gly Val Trp Lys Ser Pro Thr Asp Met Gln Ser Trp Val Pro 
305                 310                 315                 320 


Leu Ser Thr Asp Asp Pro Val Ile Asp Arg Leu Tyr Leu Ser Ser His 
                325                 330                 335     


Arg Gly Val Ile Ala Asp Asn Gln Ala Lys Trp Ala Val Pro Thr Thr 
            340                 345                 350         


Arg Thr Asp Asp Lys Leu Arg Met Glu Thr Cys Phe Gln Gln Ala Cys 
        355                 360                 365             


Lys Gly Lys Ile Gln Ala Leu Cys Glu Asn Pro Glu Trp Ala Pro Leu 
    370                 375                 380                 


Lys Asp Asn Arg Ile Pro Ser Tyr Gly Val Leu Ser Val Asp Leu Ser 
385                 390                 395                 400 


Leu Thr Val Glu Leu Lys Ile Lys Ile Ala Ser Gly Phe Gly Pro Leu 
                405                 410                 415     


Ile Thr His Gly Ser Gly Met Asp Leu Tyr Lys Ser Asn His Asn Asn 
            420                 425                 430         


Val Tyr Trp Leu Thr Ile Pro Pro Met Lys Asn Leu Ala Leu Gly Val 
        435                 440                 445             


Ile Asn Thr Leu Glu Trp Ile Pro Arg Phe Lys Val Ser Pro Ala Leu 
    450                 455                 460                 


Phe Thr Val Pro Ile Lys Glu Ala Gly Gly Asp Cys His Ala Pro Thr 
465                 470                 475                 480 


Tyr Leu Pro Ala Glu Val Asp Gly Asp Val Lys Leu Ser Ser Asn Leu 
                485                 490                 495     


Val Ile Leu Pro Gly Gln Asp Leu Gln Tyr Val Leu Ala Thr Tyr Asp 
            500                 505                 510         


Thr Ser Ala Val Glu His Ala Val Val Tyr Tyr Val Tyr Ser Pro Ser 
        515                 520                 525             


Arg Leu Ser Ser Tyr Phe Tyr Pro Phe Arg Leu Pro Ile Lys Gly Val 
    530                 535                 540                 


Pro Ile Glu Leu Gln Val Glu Cys Phe Thr Trp Asp Gln Lys Leu Trp 
545                 550                 555                 560 


Cys Arg His Phe Cys Val Leu Ala Asp Ser Glu Ser Gly Gly His Ile 
                565                 570                 575     


Thr His Ser Gly Met Val Gly Met Gly Val Ser Cys Thr Val Thr Arg 
            580                 585                 590         


Glu Asp Gly Thr Asn Ala Ala Gln Pro Ala Asp Leu Gly Lys Lys Leu 
        595                 600                 605             


Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp Glu Val Arg Ile Leu Met 
    610                 615                 620                 


Ala Asn Gly Ala Asp Val Asn Ala Thr Asp Thr Leu Gly Arg Thr Pro 
625                 630                 635                 640 


Leu His Leu Ala Ala Gln Asn Gly His Leu Glu Ile Val Glu Val Leu 
                645                 650                 655     


Leu Lys His Ser Ala Asp Val Asn Ala Ile Glu Glu Val Gly Met Thr 
            660                 665                 670         


Pro Leu His Leu Ala Val Val Ala Gly His Leu Glu Ile Val Glu Val 
        675                 680                 685             


Leu Leu Lys Asn Gly Ala Asp Val Asn Ala Gln Asp Lys Phe Gly Lys 
    690                 695                 700                 


Thr Ala Phe Asp Ile Ser Ile Asp Tyr Gly Asn Glu Asp Leu Ala Glu 
705                 710                 715                 720 


Ile Leu Gln Lys Leu Asn Ala Ala Ala Arg Gly Ser His His His His 
                725                 730                 735     


His His 
        


<210>  3
<211>  2529
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Truncated and mutated (E501A, W504A, Q530A, E533A) NiV G protein

       (GcDelta34) fused to a single chain antibody directed to human 
       CD8 (scFvC8-Vh1) linked with an additional (G4S)3 linker


<220>
<221>  CDS
<222>  (1)..(2529)

<400>  3
atg aag aag atc aac gag ggc ctg ctg gac agc aag atc ctg agc gcc         48
Met Lys Lys Ile Asn Glu Gly Leu Leu Asp Ser Lys Ile Leu Ser Ala           
1               5                   10                  15                

ttc aac acc gtg atc gcc ctg ctg ggc agc atc gtg atc att gtg atg         96
Phe Asn Thr Val Ile Ala Leu Leu Gly Ser Ile Val Ile Ile Val Met           
            20                  25                  30                    

aac atc atg atc atc cag aac tac acc aga agc acc gac aac cag gcc        144
Asn Ile Met Ile Ile Gln Asn Tyr Thr Arg Ser Thr Asp Asn Gln Ala           
        35                  40                  45                        

gtg atc aag gac gct ctc cag ggg atc cag cag cag atc aag ggc ctg        192
Val Ile Lys Asp Ala Leu Gln Gly Ile Gln Gln Gln Ile Lys Gly Leu           
    50                  55                  60                            

gcc gac aag atc ggc acc gag atc ggc ccc aag gtg tcc ctg atc gac        240
Ala Asp Lys Ile Gly Thr Glu Ile Gly Pro Lys Val Ser Leu Ile Asp           
65                  70                  75                  80            

acc agc agc acc atc acc atc ccc gcc aac atc ggc ctg ctg ggg tcc        288
Thr Ser Ser Thr Ile Thr Ile Pro Ala Asn Ile Gly Leu Leu Gly Ser           
                85                  90                  95                

aag atc agc cag agc acc gcc agc atc aac gag aac gtg aac gag aag        336
Lys Ile Ser Gln Ser Thr Ala Ser Ile Asn Glu Asn Val Asn Glu Lys           
            100                 105                 110                   

tgc aag ttc acc ctg ccc ccc ctg aag atc cac gag tgc aac atc agc        384
Cys Lys Phe Thr Leu Pro Pro Leu Lys Ile His Glu Cys Asn Ile Ser           
        115                 120                 125                       

tgc ccc aac ccc ctg ccc ttc cgg gag tac cgg ccc cag acc gag ggc        432
Cys Pro Asn Pro Leu Pro Phe Arg Glu Tyr Arg Pro Gln Thr Glu Gly           
    130                 135                 140                           

gtg agc aac ctg gtc ggc ctg ccc aac aac atc tgc ctg cag aaa acc        480
Val Ser Asn Leu Val Gly Leu Pro Asn Asn Ile Cys Leu Gln Lys Thr           
145                 150                 155                 160           

agc aac cag atc ctg aag ccc aag ctc att tcc tac acc ctg ccc gtg        528
Ser Asn Gln Ile Leu Lys Pro Lys Leu Ile Ser Tyr Thr Leu Pro Val           
                165                 170                 175               

gtg ggc cag agc ggc acc tgc atc acc gac ccc ctg ctg gcc atg gac        576
Val Gly Gln Ser Gly Thr Cys Ile Thr Asp Pro Leu Leu Ala Met Asp           
            180                 185                 190                   

gag ggc tac ttc gcc tac agc cac ctg gaa cgg atc ggc agc tgc agc        624
Glu Gly Tyr Phe Ala Tyr Ser His Leu Glu Arg Ile Gly Ser Cys Ser           
        195                 200                 205                       

agg ggc gtg tcc aag cag cgg atc atc ggc gtg ggc gag gtg ctg gac        672
Arg Gly Val Ser Lys Gln Arg Ile Ile Gly Val Gly Glu Val Leu Asp           
    210                 215                 220                           

cgg ggc gac gag gtg ccc agc ctg ttc atg acc aac gtg tgg acc ccc        720
Arg Gly Asp Glu Val Pro Ser Leu Phe Met Thr Asn Val Trp Thr Pro           
225                 230                 235                 240           

ccc aac ccc aac acc gtg tac cac tgc agc gcc gtg tac aac aac gag        768
Pro Asn Pro Asn Thr Val Tyr His Cys Ser Ala Val Tyr Asn Asn Glu           
                245                 250                 255               

ttc tac tac gtg ctg tgc gcc gtg agc acc gtg ggc gac ccc atc ctg        816
Phe Tyr Tyr Val Leu Cys Ala Val Ser Thr Val Gly Asp Pro Ile Leu           
            260                 265                 270                   

aac agc acc tac tgg tcc ggc agc ctg atg atg acc cgg ctg gcc gtg        864
Asn Ser Thr Tyr Trp Ser Gly Ser Leu Met Met Thr Arg Leu Ala Val           
        275                 280                 285                       

aag cct aag agc aat ggc ggc gga tac aac cag cac cag ctg gcc ctg        912
Lys Pro Lys Ser Asn Gly Gly Gly Tyr Asn Gln His Gln Leu Ala Leu           
    290                 295                 300                           

cgg agc atc gag aag ggc aga tac gac aaa gtg atg ccc tac ggc ccc        960
Arg Ser Ile Glu Lys Gly Arg Tyr Asp Lys Val Met Pro Tyr Gly Pro           
305                 310                 315                 320           

agc ggc atc aag cag ggc gac aca ctg tac ttc ccc gcc gtg ggc ttc       1008
Ser Gly Ile Lys Gln Gly Asp Thr Leu Tyr Phe Pro Ala Val Gly Phe           
                325                 330                 335               

ctg gtc cgg acc gag ttc aag tac aac gac agc aac tgc ccc atc acc       1056
Leu Val Arg Thr Glu Phe Lys Tyr Asn Asp Ser Asn Cys Pro Ile Thr           
            340                 345                 350                   

aag tgc cag tac agc aag ccc gag aac tgc aga ctg agc atg ggc atc       1104
Lys Cys Gln Tyr Ser Lys Pro Glu Asn Cys Arg Leu Ser Met Gly Ile           
        355                 360                 365                       

cgg ccc aac agc cac tac atc ctg cgg agc ggc ctg ctg aag tac aac       1152
Arg Pro Asn Ser His Tyr Ile Leu Arg Ser Gly Leu Leu Lys Tyr Asn           
    370                 375                 380                           

ctg agc gac ggc gag aac ccc aaa gtc gtc ttt att gag atc agc gac       1200
Leu Ser Asp Gly Glu Asn Pro Lys Val Val Phe Ile Glu Ile Ser Asp           
385                 390                 395                 400           

cag cgg ctg tcc atc ggc agc ccc agc aag atc tac gac agc ctg ggc       1248
Gln Arg Leu Ser Ile Gly Ser Pro Ser Lys Ile Tyr Asp Ser Leu Gly           
                405                 410                 415               

cag ccc gtg ttc tac cag gcc agc ttc agc tgg gac acc atg atc aag       1296
Gln Pro Val Phe Tyr Gln Ala Ser Phe Ser Trp Asp Thr Met Ile Lys           
            420                 425                 430                   

ttc ggc gac gtg ctg acc gtg aac ccc ctg gtg gtg aac tgg cgg aac       1344
Phe Gly Asp Val Leu Thr Val Asn Pro Leu Val Val Asn Trp Arg Asn           
        435                 440                 445                       

aat acc gtg atc agc aga ccc ggc cag agc cag tgc ccc cgg ttc aac       1392
Asn Thr Val Ile Ser Arg Pro Gly Gln Ser Gln Cys Pro Arg Phe Asn           
    450                 455                 460                           

acc tgc ccc gcg atc tgc gcg gag ggc gtg tac aac gac gcc ttc ctg       1440
Thr Cys Pro Ala Ile Cys Ala Glu Gly Val Tyr Asn Asp Ala Phe Leu           
465                 470                 475                 480           

atc gac cgg atc aac tgg atc tct gcc ggc gtg ttc ctg gac tcc aac       1488
Ile Asp Arg Ile Asn Trp Ile Ser Ala Gly Val Phe Leu Asp Ser Asn           
                485                 490                 495               

gcg acc gcc gcg aat ccc gtg ttc acc gtg ttt aag gac aac gag atc       1536
Ala Thr Ala Ala Asn Pro Val Phe Thr Val Phe Lys Asp Asn Glu Ile           
            500                 505                 510                   

ctg tac cgg gcc cag ctg gcc agc gag gac acc aac gcc cag aaa acc       1584
Leu Tyr Arg Ala Gln Leu Ala Ser Glu Asp Thr Asn Ala Gln Lys Thr           
        515                 520                 525                       

atc acc aac tgc ttt ctg ctg aag aac aag atc tgg tgc atc agc ctg       1632
Ile Thr Asn Cys Phe Leu Leu Lys Asn Lys Ile Trp Cys Ile Ser Leu           
    530                 535                 540                           

gtg gag atc tac gat acc ggc gac aac gtg atc agg ccc aag ctg ttc       1680
Val Glu Ile Tyr Asp Thr Gly Asp Asn Val Ile Arg Pro Lys Leu Phe           
545                 550                 555                 560           

gcc gtg aag atc ccc gag cag tgc acc ggt gga ggt ggc tct ggt gga       1728
Ala Val Lys Ile Pro Glu Gln Cys Thr Gly Gly Gly Gly Ser Gly Gly           
                565                 570                 575               

gga ggc tct gga ggt ggt gga tca gcg gcc cag ccg gcc cag gtg cag       1776
Gly Gly Ser Gly Gly Gly Gly Ser Ala Ala Gln Pro Ala Gln Val Gln           
            580                 585                 590                   

ctg gtg cag agc gga gcc gag gat aag aaa cct ggc gct agc gtg aag       1824
Leu Val Gln Ser Gly Ala Glu Asp Lys Lys Pro Gly Ala Ser Val Lys           
        595                 600                 605                       

gtg tcc tgc aag gcc agc ggc ttc aac atc aag gac acc tac atc cac       1872
Val Ser Cys Lys Ala Ser Gly Phe Asn Ile Lys Asp Thr Tyr Ile His           
    610                 615                 620                           

tgg gtg cgc cag gct cca gga cag ggc ctg gaa tgg atg ggc cgg atc       1920
Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Arg Ile           
625                 630                 635                 640           

gac ccc gcc aac gac aac acc ctg tac gcc agc aag ttc cag ggc aga       1968
Asp Pro Ala Asn Asp Asn Thr Leu Tyr Ala Ser Lys Phe Gln Gly Arg           
                645                 650                 655               

gtg acc atc acc gcc gac acc agc agc aac acc gcc tac atg gaa ctg       2016
Val Thr Ile Thr Ala Asp Thr Ser Ser Asn Thr Ala Tyr Met Glu Leu           
            660                 665                 670                   

agc agc ctg aga agc gag gac acc gcc gtg tac tac tgt ggc aga ggc       2064
Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Gly Arg Gly           
        675                 680                 685                       

tac ggc tac tac gtg ttc gac cac tgg ggc cag ggc acc acc gtg aca       2112
Tyr Gly Tyr Tyr Val Phe Asp His Trp Gly Gln Gly Thr Thr Val Thr           
    690                 695                 700                           

gtg tct agc ggc gga ggc gga agt gga ggc gga gga agc gga ggc ggc       2160
Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly           
705                 710                 715                 720           

gga tcc gac atc gtg atg acc cag agc cct agc agc ctg tct gcc agc       2208
Gly Ser Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser           
                725                 730                 735               

gtg ggc gac cgc gtg acc att acc tgc cgg acc agc cgg tcc atc agc       2256
Val Gly Asp Arg Val Thr Ile Thr Cys Arg Thr Ser Arg Ser Ile Ser           
            740                 745                 750                   

cag tac ctg gcc tgg tat cag gaa aag ccc ggc aag gcc ccc aag ctg       2304
Gln Tyr Leu Ala Trp Tyr Gln Glu Lys Pro Gly Lys Ala Pro Lys Leu           
        755                 760                 765                       

ctg atc tac agc ggc agc acc ctg cag agc ggc gtg cca agc aga ttc       2352
Leu Ile Tyr Ser Gly Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe           
    770                 775                 780                           

agc ggc agc ggc tcc ggc acc gac ttc acc ctg acc atc agc agc ctg       2400
Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu           
785                 790                 795                 800           

cag ccc gag gac ttc gcc acc tac tac tgc cag cag cac aac gag aac       2448
Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Asn Glu Asn           
                805                 810                 815               

ccc ctg acc ttc ggg cag gga aca aag gtg gag atc aag aga gcg gcc       2496
Pro Leu Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Ala Ala           
            820                 825                 830                   

gca aga ggt tct cat cac cat cac cat cac taa                           2529
Ala Arg Gly Ser His His His His His His                                   
        835                 840                                           


<210>  4
<211>  842
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  4

Met Lys Lys Ile Asn Glu Gly Leu Leu Asp Ser Lys Ile Leu Ser Ala 
1               5                   10                  15      


Phe Asn Thr Val Ile Ala Leu Leu Gly Ser Ile Val Ile Ile Val Met 
            20                  25                  30          


Asn Ile Met Ile Ile Gln Asn Tyr Thr Arg Ser Thr Asp Asn Gln Ala 
        35                  40                  45              


Val Ile Lys Asp Ala Leu Gln Gly Ile Gln Gln Gln Ile Lys Gly Leu 
    50                  55                  60                  


Ala Asp Lys Ile Gly Thr Glu Ile Gly Pro Lys Val Ser Leu Ile Asp 
65                  70                  75                  80  


Thr Ser Ser Thr Ile Thr Ile Pro Ala Asn Ile Gly Leu Leu Gly Ser 
                85                  90                  95      


Lys Ile Ser Gln Ser Thr Ala Ser Ile Asn Glu Asn Val Asn Glu Lys 
            100                 105                 110         


Cys Lys Phe Thr Leu Pro Pro Leu Lys Ile His Glu Cys Asn Ile Ser 
        115                 120                 125             


Cys Pro Asn Pro Leu Pro Phe Arg Glu Tyr Arg Pro Gln Thr Glu Gly 
    130                 135                 140                 


Val Ser Asn Leu Val Gly Leu Pro Asn Asn Ile Cys Leu Gln Lys Thr 
145                 150                 155                 160 


Ser Asn Gln Ile Leu Lys Pro Lys Leu Ile Ser Tyr Thr Leu Pro Val 
                165                 170                 175     


Val Gly Gln Ser Gly Thr Cys Ile Thr Asp Pro Leu Leu Ala Met Asp 
            180                 185                 190         


Glu Gly Tyr Phe Ala Tyr Ser His Leu Glu Arg Ile Gly Ser Cys Ser 
        195                 200                 205             


Arg Gly Val Ser Lys Gln Arg Ile Ile Gly Val Gly Glu Val Leu Asp 
    210                 215                 220                 


Arg Gly Asp Glu Val Pro Ser Leu Phe Met Thr Asn Val Trp Thr Pro 
225                 230                 235                 240 


Pro Asn Pro Asn Thr Val Tyr His Cys Ser Ala Val Tyr Asn Asn Glu 
                245                 250                 255     


Phe Tyr Tyr Val Leu Cys Ala Val Ser Thr Val Gly Asp Pro Ile Leu 
            260                 265                 270         


Asn Ser Thr Tyr Trp Ser Gly Ser Leu Met Met Thr Arg Leu Ala Val 
        275                 280                 285             


Lys Pro Lys Ser Asn Gly Gly Gly Tyr Asn Gln His Gln Leu Ala Leu 
    290                 295                 300                 


Arg Ser Ile Glu Lys Gly Arg Tyr Asp Lys Val Met Pro Tyr Gly Pro 
305                 310                 315                 320 


Ser Gly Ile Lys Gln Gly Asp Thr Leu Tyr Phe Pro Ala Val Gly Phe 
                325                 330                 335     


Leu Val Arg Thr Glu Phe Lys Tyr Asn Asp Ser Asn Cys Pro Ile Thr 
            340                 345                 350         


Lys Cys Gln Tyr Ser Lys Pro Glu Asn Cys Arg Leu Ser Met Gly Ile 
        355                 360                 365             


Arg Pro Asn Ser His Tyr Ile Leu Arg Ser Gly Leu Leu Lys Tyr Asn 
    370                 375                 380                 


Leu Ser Asp Gly Glu Asn Pro Lys Val Val Phe Ile Glu Ile Ser Asp 
385                 390                 395                 400 


Gln Arg Leu Ser Ile Gly Ser Pro Ser Lys Ile Tyr Asp Ser Leu Gly 
                405                 410                 415     


Gln Pro Val Phe Tyr Gln Ala Ser Phe Ser Trp Asp Thr Met Ile Lys 
            420                 425                 430         


Phe Gly Asp Val Leu Thr Val Asn Pro Leu Val Val Asn Trp Arg Asn 
        435                 440                 445             


Asn Thr Val Ile Ser Arg Pro Gly Gln Ser Gln Cys Pro Arg Phe Asn 
    450                 455                 460                 


Thr Cys Pro Ala Ile Cys Ala Glu Gly Val Tyr Asn Asp Ala Phe Leu 
465                 470                 475                 480 


Ile Asp Arg Ile Asn Trp Ile Ser Ala Gly Val Phe Leu Asp Ser Asn 
                485                 490                 495     


Ala Thr Ala Ala Asn Pro Val Phe Thr Val Phe Lys Asp Asn Glu Ile 
            500                 505                 510         


Leu Tyr Arg Ala Gln Leu Ala Ser Glu Asp Thr Asn Ala Gln Lys Thr 
        515                 520                 525             


Ile Thr Asn Cys Phe Leu Leu Lys Asn Lys Ile Trp Cys Ile Ser Leu 
    530                 535                 540                 


Val Glu Ile Tyr Asp Thr Gly Asp Asn Val Ile Arg Pro Lys Leu Phe 
545                 550                 555                 560 


Ala Val Lys Ile Pro Glu Gln Cys Thr Gly Gly Gly Gly Ser Gly Gly 
                565                 570                 575     


Gly Gly Ser Gly Gly Gly Gly Ser Ala Ala Gln Pro Ala Gln Val Gln 
            580                 585                 590         


Leu Val Gln Ser Gly Ala Glu Asp Lys Lys Pro Gly Ala Ser Val Lys 
        595                 600                 605             


Val Ser Cys Lys Ala Ser Gly Phe Asn Ile Lys Asp Thr Tyr Ile His 
    610                 615                 620                 


Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Arg Ile 
625                 630                 635                 640 


Asp Pro Ala Asn Asp Asn Thr Leu Tyr Ala Ser Lys Phe Gln Gly Arg 
                645                 650                 655     


Val Thr Ile Thr Ala Asp Thr Ser Ser Asn Thr Ala Tyr Met Glu Leu 
            660                 665                 670         


Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Gly Arg Gly 
        675                 680                 685             


Tyr Gly Tyr Tyr Val Phe Asp His Trp Gly Gln Gly Thr Thr Val Thr 
    690                 695                 700                 


Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
705                 710                 715                 720 


Gly Ser Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser 
                725                 730                 735     


Val Gly Asp Arg Val Thr Ile Thr Cys Arg Thr Ser Arg Ser Ile Ser 
            740                 745                 750         


Gln Tyr Leu Ala Trp Tyr Gln Glu Lys Pro Gly Lys Ala Pro Lys Leu 
        755                 760                 765             


Leu Ile Tyr Ser Gly Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe 
    770                 775                 780                 


Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu 
785                 790                 795                 800 


Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Asn Glu Asn 
                805                 810                 815     


Pro Leu Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Ala Ala 
            820                 825                 830         


Ala Arg Gly Ser His His His His His His 
        835                 840         


<210>  5
<211>  2211
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Truncated and mutated (E501A, W504A, Q530A, E533A) NiV G protein

       (GcDelta34) fused to IL-7


<220>
<221>  CDS
<222>  (1)..(2211)

<400>  5
atg aag aag atc aac gag ggc ctg ctg gac agc aag atc ctg agc gcc         48
Met Lys Lys Ile Asn Glu Gly Leu Leu Asp Ser Lys Ile Leu Ser Ala           
1               5                   10                  15                

ttc aac acc gtg atc gcc ctg ctg ggc agc atc gtg atc att gtg atg         96
Phe Asn Thr Val Ile Ala Leu Leu Gly Ser Ile Val Ile Ile Val Met           
            20                  25                  30                    

aac atc atg atc atc cag aac tac acc aga agc acc gac aac cag gcc        144
Asn Ile Met Ile Ile Gln Asn Tyr Thr Arg Ser Thr Asp Asn Gln Ala           
        35                  40                  45                        

gtg atc aag gac gct ctc cag ggg atc cag cag cag atc aag ggc ctg        192
Val Ile Lys Asp Ala Leu Gln Gly Ile Gln Gln Gln Ile Lys Gly Leu           
    50                  55                  60                            

gcc gac aag atc ggc acc gag atc ggc ccc aag gtg tcc ctg atc gac        240
Ala Asp Lys Ile Gly Thr Glu Ile Gly Pro Lys Val Ser Leu Ile Asp           
65                  70                  75                  80            

acc agc agc acc atc acc atc ccc gcc aac atc ggc ctg ctg ggg tcc        288
Thr Ser Ser Thr Ile Thr Ile Pro Ala Asn Ile Gly Leu Leu Gly Ser           
                85                  90                  95                

aag atc agc cag agc acc gcc agc atc aac gag aac gtg aac gag aag        336
Lys Ile Ser Gln Ser Thr Ala Ser Ile Asn Glu Asn Val Asn Glu Lys           
            100                 105                 110                   

tgc aag ttc acc ctg ccc ccc ctg aag atc cac gag tgc aac atc agc        384
Cys Lys Phe Thr Leu Pro Pro Leu Lys Ile His Glu Cys Asn Ile Ser           
        115                 120                 125                       

tgc ccc aac ccc ctg ccc ttc cgg gag tac cgg ccc cag acc gag ggc        432
Cys Pro Asn Pro Leu Pro Phe Arg Glu Tyr Arg Pro Gln Thr Glu Gly           
    130                 135                 140                           

gtg agc aac ctg gtc ggc ctg ccc aac aac atc tgc ctg cag aaa acc        480
Val Ser Asn Leu Val Gly Leu Pro Asn Asn Ile Cys Leu Gln Lys Thr           
145                 150                 155                 160           

agc aac cag atc ctg aag ccc aag ctc att tcc tac acc ctg ccc gtg        528
Ser Asn Gln Ile Leu Lys Pro Lys Leu Ile Ser Tyr Thr Leu Pro Val           
                165                 170                 175               

gtg ggc cag agc ggc acc tgc atc acc gac ccc ctg ctg gcc atg gac        576
Val Gly Gln Ser Gly Thr Cys Ile Thr Asp Pro Leu Leu Ala Met Asp           
            180                 185                 190                   

gag ggc tac ttc gcc tac agc cac ctg gaa cgg atc ggc agc tgc agc        624
Glu Gly Tyr Phe Ala Tyr Ser His Leu Glu Arg Ile Gly Ser Cys Ser           
        195                 200                 205                       

agg ggc gtg tcc aag cag cgg atc atc ggc gtg ggc gag gtg ctg gac        672
Arg Gly Val Ser Lys Gln Arg Ile Ile Gly Val Gly Glu Val Leu Asp           
    210                 215                 220                           

cgg ggc gac gag gtg ccc agc ctg ttc atg acc aac gtg tgg acc ccc        720
Arg Gly Asp Glu Val Pro Ser Leu Phe Met Thr Asn Val Trp Thr Pro           
225                 230                 235                 240           

ccc aac ccc aac acc gtg tac cac tgc agc gcc gtg tac aac aac gag        768
Pro Asn Pro Asn Thr Val Tyr His Cys Ser Ala Val Tyr Asn Asn Glu           
                245                 250                 255               

ttc tac tac gtg ctg tgc gcc gtg agc acc gtg ggc gac ccc atc ctg        816
Phe Tyr Tyr Val Leu Cys Ala Val Ser Thr Val Gly Asp Pro Ile Leu           
            260                 265                 270                   

aac agc acc tac tgg tcc ggc agc ctg atg atg acc cgg ctg gcc gtg        864
Asn Ser Thr Tyr Trp Ser Gly Ser Leu Met Met Thr Arg Leu Ala Val           
        275                 280                 285                       

aag cct aag agc aat ggc ggc gga tac aac cag cac cag ctg gcc ctg        912
Lys Pro Lys Ser Asn Gly Gly Gly Tyr Asn Gln His Gln Leu Ala Leu           
    290                 295                 300                           

cgg agc atc gag aag ggc aga tac gac aaa gtg atg ccc tac ggc ccc        960
Arg Ser Ile Glu Lys Gly Arg Tyr Asp Lys Val Met Pro Tyr Gly Pro           
305                 310                 315                 320           

agc ggc atc aag cag ggc gac aca ctg tac ttc ccc gcc gtg ggc ttc       1008
Ser Gly Ile Lys Gln Gly Asp Thr Leu Tyr Phe Pro Ala Val Gly Phe           
                325                 330                 335               

ctg gtc cgg acc gag ttc aag tac aac gac agc aac tgc ccc atc acc       1056
Leu Val Arg Thr Glu Phe Lys Tyr Asn Asp Ser Asn Cys Pro Ile Thr           
            340                 345                 350                   

aag tgc cag tac agc aag ccc gag aac tgc aga ctg agc atg ggc atc       1104
Lys Cys Gln Tyr Ser Lys Pro Glu Asn Cys Arg Leu Ser Met Gly Ile           
        355                 360                 365                       

cgg ccc aac agc cac tac atc ctg cgg agc ggc ctg ctg aag tac aac       1152
Arg Pro Asn Ser His Tyr Ile Leu Arg Ser Gly Leu Leu Lys Tyr Asn           
    370                 375                 380                           

ctg agc gac ggc gag aac ccc aaa gtc gtc ttt att gag atc agc gac       1200
Leu Ser Asp Gly Glu Asn Pro Lys Val Val Phe Ile Glu Ile Ser Asp           
385                 390                 395                 400           

cag cgg ctg tcc atc ggc agc ccc agc aag atc tac gac agc ctg ggc       1248
Gln Arg Leu Ser Ile Gly Ser Pro Ser Lys Ile Tyr Asp Ser Leu Gly           
                405                 410                 415               

cag ccc gtg ttc tac cag gcc agc ttc agc tgg gac acc atg atc aag       1296
Gln Pro Val Phe Tyr Gln Ala Ser Phe Ser Trp Asp Thr Met Ile Lys           
            420                 425                 430                   

ttc ggc gac gtg ctg acc gtg aac ccc ctg gtg gtg aac tgg cgg aac       1344
Phe Gly Asp Val Leu Thr Val Asn Pro Leu Val Val Asn Trp Arg Asn           
        435                 440                 445                       

aat acc gtg atc agc aga ccc ggc cag agc cag tgc ccc cgg ttc aac       1392
Asn Thr Val Ile Ser Arg Pro Gly Gln Ser Gln Cys Pro Arg Phe Asn           
    450                 455                 460                           

acc tgc ccc gcg atc tgc gcg gag ggc gtg tac aac gac gcc ttc ctg       1440
Thr Cys Pro Ala Ile Cys Ala Glu Gly Val Tyr Asn Asp Ala Phe Leu           
465                 470                 475                 480           

atc gac cgg atc aac tgg atc tct gcc ggc gtg ttc ctg gac tcc aac       1488
Ile Asp Arg Ile Asn Trp Ile Ser Ala Gly Val Phe Leu Asp Ser Asn           
                485                 490                 495               

gcg acc gcc gcg aat ccc gtg ttc acc gtg ttt aag gac aac gag atc       1536
Ala Thr Ala Ala Asn Pro Val Phe Thr Val Phe Lys Asp Asn Glu Ile           
            500                 505                 510                   

ctg tac cgg gcc cag ctg gcc agc gag gac acc aac gcc cag aaa acc       1584
Leu Tyr Arg Ala Gln Leu Ala Ser Glu Asp Thr Asn Ala Gln Lys Thr           
        515                 520                 525                       

atc acc aac tgc ttt ctg ctg aag aac aag atc tgg tgc atc agc ctg       1632
Ile Thr Asn Cys Phe Leu Leu Lys Asn Lys Ile Trp Cys Ile Ser Leu           
    530                 535                 540                           

gtg gag atc tac gat acc ggc gac aac gtg atc agg ccc aag ctg ttc       1680
Val Glu Ile Tyr Asp Thr Gly Asp Asn Val Ile Arg Pro Lys Leu Phe           
545                 550                 555                 560           

gcc gtg aag atc ccc gag cag tgc acc ggt atg gcc gat tgt gat att       1728
Ala Val Lys Ile Pro Glu Gln Cys Thr Gly Met Ala Asp Cys Asp Ile           
                565                 570                 575               

gaa ggt aaa gat ggc aaa caa tat gag agt gtt cta atg gtc agc atc       1776
Glu Gly Lys Asp Gly Lys Gln Tyr Glu Ser Val Leu Met Val Ser Ile           
            580                 585                 590                   

gat caa tta ttg gac agc atg aaa gaa att ggt agc aat tgc ctg aat       1824
Asp Gln Leu Leu Asp Ser Met Lys Glu Ile Gly Ser Asn Cys Leu Asn           
        595                 600                 605                       

aat gaa ttt aac ttt ttt aaa aga cat atc tgt gat gct aat aag gaa       1872
Asn Glu Phe Asn Phe Phe Lys Arg His Ile Cys Asp Ala Asn Lys Glu           
    610                 615                 620                           

ggt atg ttt tta ttc cgt gct gct cgc aag ttg agg caa ttt ctt aaa       1920
Gly Met Phe Leu Phe Arg Ala Ala Arg Lys Leu Arg Gln Phe Leu Lys           
625                 630                 635                 640           

atg aat agc act ggt gat ttt gat ctc cac tta tta aaa gtt tca gaa       1968
Met Asn Ser Thr Gly Asp Phe Asp Leu His Leu Leu Lys Val Ser Glu           
                645                 650                 655               

ggc aca aca ata ctg ttg aac tgc act ggc cag gtt aaa gga aga aaa       2016
Gly Thr Thr Ile Leu Leu Asn Cys Thr Gly Gln Val Lys Gly Arg Lys           
            660                 665                 670                   

cca gct gcc ctg ggt gaa gcc caa cca aca aag agt ttg gaa gaa aat       2064
Pro Ala Ala Leu Gly Glu Ala Gln Pro Thr Lys Ser Leu Glu Glu Asn           
        675                 680                 685                       

aaa tct tta aag gaa cag aaa aaa ctg aat gac ttg tgt ttc cta aag       2112
Lys Ser Leu Lys Glu Gln Lys Lys Leu Asn Asp Leu Cys Phe Leu Lys           
    690                 695                 700                           

aga cta tta caa gag ata aaa act tgt tgg aat aaa att ttg atg ggc       2160
Arg Leu Leu Gln Glu Ile Lys Thr Cys Trp Asn Lys Ile Leu Met Gly           
705                 710                 715                 720           

act aaa gaa cac gcg gcc gca aga ggt tct cat cac cat cac cat cac       2208
Thr Lys Glu His Ala Ala Ala Arg Gly Ser His His His His His His           
                725                 730                 735               

taa                                                                   2211


<210>  6
<211>  736
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  6

Met Lys Lys Ile Asn Glu Gly Leu Leu Asp Ser Lys Ile Leu Ser Ala 
1               5                   10                  15      


Phe Asn Thr Val Ile Ala Leu Leu Gly Ser Ile Val Ile Ile Val Met 
            20                  25                  30          


Asn Ile Met Ile Ile Gln Asn Tyr Thr Arg Ser Thr Asp Asn Gln Ala 
        35                  40                  45              


Val Ile Lys Asp Ala Leu Gln Gly Ile Gln Gln Gln Ile Lys Gly Leu 
    50                  55                  60                  


Ala Asp Lys Ile Gly Thr Glu Ile Gly Pro Lys Val Ser Leu Ile Asp 
65                  70                  75                  80  


Thr Ser Ser Thr Ile Thr Ile Pro Ala Asn Ile Gly Leu Leu Gly Ser 
                85                  90                  95      


Lys Ile Ser Gln Ser Thr Ala Ser Ile Asn Glu Asn Val Asn Glu Lys 
            100                 105                 110         


Cys Lys Phe Thr Leu Pro Pro Leu Lys Ile His Glu Cys Asn Ile Ser 
        115                 120                 125             


Cys Pro Asn Pro Leu Pro Phe Arg Glu Tyr Arg Pro Gln Thr Glu Gly 
    130                 135                 140                 


Val Ser Asn Leu Val Gly Leu Pro Asn Asn Ile Cys Leu Gln Lys Thr 
145                 150                 155                 160 


Ser Asn Gln Ile Leu Lys Pro Lys Leu Ile Ser Tyr Thr Leu Pro Val 
                165                 170                 175     


Val Gly Gln Ser Gly Thr Cys Ile Thr Asp Pro Leu Leu Ala Met Asp 
            180                 185                 190         


Glu Gly Tyr Phe Ala Tyr Ser His Leu Glu Arg Ile Gly Ser Cys Ser 
        195                 200                 205             


Arg Gly Val Ser Lys Gln Arg Ile Ile Gly Val Gly Glu Val Leu Asp 
    210                 215                 220                 


Arg Gly Asp Glu Val Pro Ser Leu Phe Met Thr Asn Val Trp Thr Pro 
225                 230                 235                 240 


Pro Asn Pro Asn Thr Val Tyr His Cys Ser Ala Val Tyr Asn Asn Glu 
                245                 250                 255     


Phe Tyr Tyr Val Leu Cys Ala Val Ser Thr Val Gly Asp Pro Ile Leu 
            260                 265                 270         


Asn Ser Thr Tyr Trp Ser Gly Ser Leu Met Met Thr Arg Leu Ala Val 
        275                 280                 285             


Lys Pro Lys Ser Asn Gly Gly Gly Tyr Asn Gln His Gln Leu Ala Leu 
    290                 295                 300                 


Arg Ser Ile Glu Lys Gly Arg Tyr Asp Lys Val Met Pro Tyr Gly Pro 
305                 310                 315                 320 


Ser Gly Ile Lys Gln Gly Asp Thr Leu Tyr Phe Pro Ala Val Gly Phe 
                325                 330                 335     


Leu Val Arg Thr Glu Phe Lys Tyr Asn Asp Ser Asn Cys Pro Ile Thr 
            340                 345                 350         


Lys Cys Gln Tyr Ser Lys Pro Glu Asn Cys Arg Leu Ser Met Gly Ile 
        355                 360                 365             


Arg Pro Asn Ser His Tyr Ile Leu Arg Ser Gly Leu Leu Lys Tyr Asn 
    370                 375                 380                 


Leu Ser Asp Gly Glu Asn Pro Lys Val Val Phe Ile Glu Ile Ser Asp 
385                 390                 395                 400 


Gln Arg Leu Ser Ile Gly Ser Pro Ser Lys Ile Tyr Asp Ser Leu Gly 
                405                 410                 415     


Gln Pro Val Phe Tyr Gln Ala Ser Phe Ser Trp Asp Thr Met Ile Lys 
            420                 425                 430         


Phe Gly Asp Val Leu Thr Val Asn Pro Leu Val Val Asn Trp Arg Asn 
        435                 440                 445             


Asn Thr Val Ile Ser Arg Pro Gly Gln Ser Gln Cys Pro Arg Phe Asn 
    450                 455                 460                 


Thr Cys Pro Ala Ile Cys Ala Glu Gly Val Tyr Asn Asp Ala Phe Leu 
465                 470                 475                 480 


Ile Asp Arg Ile Asn Trp Ile Ser Ala Gly Val Phe Leu Asp Ser Asn 
                485                 490                 495     


Ala Thr Ala Ala Asn Pro Val Phe Thr Val Phe Lys Asp Asn Glu Ile 
            500                 505                 510         


Leu Tyr Arg Ala Gln Leu Ala Ser Glu Asp Thr Asn Ala Gln Lys Thr 
        515                 520                 525             


Ile Thr Asn Cys Phe Leu Leu Lys Asn Lys Ile Trp Cys Ile Ser Leu 
    530                 535                 540                 


Val Glu Ile Tyr Asp Thr Gly Asp Asn Val Ile Arg Pro Lys Leu Phe 
545                 550                 555                 560 


Ala Val Lys Ile Pro Glu Gln Cys Thr Gly Met Ala Asp Cys Asp Ile 
                565                 570                 575     


Glu Gly Lys Asp Gly Lys Gln Tyr Glu Ser Val Leu Met Val Ser Ile 
            580                 585                 590         


Asp Gln Leu Leu Asp Ser Met Lys Glu Ile Gly Ser Asn Cys Leu Asn 
        595                 600                 605             


Asn Glu Phe Asn Phe Phe Lys Arg His Ile Cys Asp Ala Asn Lys Glu 
    610                 615                 620                 


Gly Met Phe Leu Phe Arg Ala Ala Arg Lys Leu Arg Gln Phe Leu Lys 
625                 630                 635                 640 


Met Asn Ser Thr Gly Asp Phe Asp Leu His Leu Leu Lys Val Ser Glu 
                645                 650                 655     


Gly Thr Thr Ile Leu Leu Asn Cys Thr Gly Gln Val Lys Gly Arg Lys 
            660                 665                 670         


Pro Ala Ala Leu Gly Glu Ala Gln Pro Thr Lys Ser Leu Glu Glu Asn 
        675                 680                 685             


Lys Ser Leu Lys Glu Gln Lys Lys Leu Asn Asp Leu Cys Phe Leu Lys 
    690                 695                 700                 


Arg Leu Leu Gln Glu Ile Lys Thr Cys Trp Asn Lys Ile Leu Met Gly 
705                 710                 715                 720 


Thr Lys Glu His Ala Ala Ala Arg Gly Ser His His His His His His 
                725                 730                 735     


<210>  7
<211>  2229
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Truncated and mutated (E501A, W504A, Q530A, E533A) NiV G protein

       (GcDelta34) fused to a designed ankaryin repeat protein (DARPin) 
       directed against human EpCAM


<220>
<221>  CDS
<222>  (1)..(2229)

<400>  7
atg aag aag atc aac gag ggc ctg ctg gac agc aag atc ctg agc gcc         48
Met Lys Lys Ile Asn Glu Gly Leu Leu Asp Ser Lys Ile Leu Ser Ala           
1               5                   10                  15                

ttc aac acc gtg atc gcc ctg ctg ggc agc atc gtg atc att gtg atg         96
Phe Asn Thr Val Ile Ala Leu Leu Gly Ser Ile Val Ile Ile Val Met           
            20                  25                  30                    

aac atc atg atc atc cag aac tac acc aga agc acc gac aac cag gcc        144
Asn Ile Met Ile Ile Gln Asn Tyr Thr Arg Ser Thr Asp Asn Gln Ala           
        35                  40                  45                        

gtg atc aag gac gct ctc cag ggg atc cag cag cag atc aag ggc ctg        192
Val Ile Lys Asp Ala Leu Gln Gly Ile Gln Gln Gln Ile Lys Gly Leu           
    50                  55                  60                            

gcc gac aag atc ggc acc gag atc ggc ccc aag gtg tcc ctg atc gac        240
Ala Asp Lys Ile Gly Thr Glu Ile Gly Pro Lys Val Ser Leu Ile Asp           
65                  70                  75                  80            

acc agc agc acc atc acc atc ccc gcc aac atc ggc ctg ctg ggg tcc        288
Thr Ser Ser Thr Ile Thr Ile Pro Ala Asn Ile Gly Leu Leu Gly Ser           
                85                  90                  95                

aag atc agc cag agc acc gcc agc atc aac gag aac gtg aac gag aag        336
Lys Ile Ser Gln Ser Thr Ala Ser Ile Asn Glu Asn Val Asn Glu Lys           
            100                 105                 110                   

tgc aag ttc acc ctg ccc ccc ctg aag atc cac gag tgc aac atc agc        384
Cys Lys Phe Thr Leu Pro Pro Leu Lys Ile His Glu Cys Asn Ile Ser           
        115                 120                 125                       

tgc ccc aac ccc ctg ccc ttc cgg gag tac cgg ccc cag acc gag ggc        432
Cys Pro Asn Pro Leu Pro Phe Arg Glu Tyr Arg Pro Gln Thr Glu Gly           
    130                 135                 140                           

gtg agc aac ctg gtc ggc ctg ccc aac aac atc tgc ctg cag aaa acc        480
Val Ser Asn Leu Val Gly Leu Pro Asn Asn Ile Cys Leu Gln Lys Thr           
145                 150                 155                 160           

agc aac cag atc ctg aag ccc aag ctc att tcc tac acc ctg ccc gtg        528
Ser Asn Gln Ile Leu Lys Pro Lys Leu Ile Ser Tyr Thr Leu Pro Val           
                165                 170                 175               

gtg ggc cag agc ggc acc tgc atc acc gac ccc ctg ctg gcc atg gac        576
Val Gly Gln Ser Gly Thr Cys Ile Thr Asp Pro Leu Leu Ala Met Asp           
            180                 185                 190                   

gag ggc tac ttc gcc tac agc cac ctg gaa cgg atc ggc agc tgc agc        624
Glu Gly Tyr Phe Ala Tyr Ser His Leu Glu Arg Ile Gly Ser Cys Ser           
        195                 200                 205                       

agg ggc gtg tcc aag cag cgg atc atc ggc gtg ggc gag gtg ctg gac        672
Arg Gly Val Ser Lys Gln Arg Ile Ile Gly Val Gly Glu Val Leu Asp           
    210                 215                 220                           

cgg ggc gac gag gtg ccc agc ctg ttc atg acc aac gtg tgg acc ccc        720
Arg Gly Asp Glu Val Pro Ser Leu Phe Met Thr Asn Val Trp Thr Pro           
225                 230                 235                 240           

ccc aac ccc aac acc gtg tac cac tgc agc gcc gtg tac aac aac gag        768
Pro Asn Pro Asn Thr Val Tyr His Cys Ser Ala Val Tyr Asn Asn Glu           
                245                 250                 255               

ttc tac tac gtg ctg tgc gcc gtg agc acc gtg ggc gac ccc atc ctg        816
Phe Tyr Tyr Val Leu Cys Ala Val Ser Thr Val Gly Asp Pro Ile Leu           
            260                 265                 270                   

aac agc acc tac tgg tcc ggc agc ctg atg atg acc cgg ctg gcc gtg        864
Asn Ser Thr Tyr Trp Ser Gly Ser Leu Met Met Thr Arg Leu Ala Val           
        275                 280                 285                       

aag cct aag agc aat ggc ggc gga tac aac cag cac cag ctg gcc ctg        912
Lys Pro Lys Ser Asn Gly Gly Gly Tyr Asn Gln His Gln Leu Ala Leu           
    290                 295                 300                           

cgg agc atc gag aag ggc aga tac gac aaa gtg atg ccc tac ggc ccc        960
Arg Ser Ile Glu Lys Gly Arg Tyr Asp Lys Val Met Pro Tyr Gly Pro           
305                 310                 315                 320           

agc ggc atc aag cag ggc gac aca ctg tac ttc ccc gcc gtg ggc ttc       1008
Ser Gly Ile Lys Gln Gly Asp Thr Leu Tyr Phe Pro Ala Val Gly Phe           
                325                 330                 335               

ctg gtc cgg acc gag ttc aag tac aac gac agc aac tgc ccc atc acc       1056
Leu Val Arg Thr Glu Phe Lys Tyr Asn Asp Ser Asn Cys Pro Ile Thr           
            340                 345                 350                   

aag tgc cag tac agc aag ccc gag aac tgc aga ctg agc atg ggc atc       1104
Lys Cys Gln Tyr Ser Lys Pro Glu Asn Cys Arg Leu Ser Met Gly Ile           
        355                 360                 365                       

cgg ccc aac agc cac tac atc ctg cgg agc ggc ctg ctg aag tac aac       1152
Arg Pro Asn Ser His Tyr Ile Leu Arg Ser Gly Leu Leu Lys Tyr Asn           
    370                 375                 380                           

ctg agc gac ggc gag aac ccc aaa gtc gtc ttt att gag atc agc gac       1200
Leu Ser Asp Gly Glu Asn Pro Lys Val Val Phe Ile Glu Ile Ser Asp           
385                 390                 395                 400           

cag cgg ctg tcc atc ggc agc ccc agc aag atc tac gac agc ctg ggc       1248
Gln Arg Leu Ser Ile Gly Ser Pro Ser Lys Ile Tyr Asp Ser Leu Gly           
                405                 410                 415               

cag ccc gtg ttc tac cag gcc agc ttc agc tgg gac acc atg atc aag       1296
Gln Pro Val Phe Tyr Gln Ala Ser Phe Ser Trp Asp Thr Met Ile Lys           
            420                 425                 430                   

ttc ggc gac gtg ctg acc gtg aac ccc ctg gtg gtg aac tgg cgg aac       1344
Phe Gly Asp Val Leu Thr Val Asn Pro Leu Val Val Asn Trp Arg Asn           
        435                 440                 445                       

aat acc gtg atc agc aga ccc ggc cag agc cag tgc ccc cgg ttc aac       1392
Asn Thr Val Ile Ser Arg Pro Gly Gln Ser Gln Cys Pro Arg Phe Asn           
    450                 455                 460                           

acc tgc ccc gcg atc tgc gcg gag ggc gtg tac aac gac gcc ttc ctg       1440
Thr Cys Pro Ala Ile Cys Ala Glu Gly Val Tyr Asn Asp Ala Phe Leu           
465                 470                 475                 480           

atc gac cgg atc aac tgg atc tct gcc ggc gtg ttc ctg gac tcc aac       1488
Ile Asp Arg Ile Asn Trp Ile Ser Ala Gly Val Phe Leu Asp Ser Asn           
                485                 490                 495               

gcg acc gcc gcg aat ccc gtg ttc acc gtg ttt aag gac aac gag atc       1536
Ala Thr Ala Ala Asn Pro Val Phe Thr Val Phe Lys Asp Asn Glu Ile           
            500                 505                 510                   

ctg tac cgg gcc cag ctg gcc agc gag gac acc aac gcc cag aaa acc       1584
Leu Tyr Arg Ala Gln Leu Ala Ser Glu Asp Thr Asn Ala Gln Lys Thr           
        515                 520                 525                       

atc acc aac tgc ttt ctg ctg aag aac aag atc tgg tgc atc agc ctg       1632
Ile Thr Asn Cys Phe Leu Leu Lys Asn Lys Ile Trp Cys Ile Ser Leu           
    530                 535                 540                           

gtg gag atc tac gat acc ggc gac aac gtg atc agg ccc aag ctg ttc       1680
Val Glu Ile Tyr Asp Thr Gly Asp Asn Val Ile Arg Pro Lys Leu Phe           
545                 550                 555                 560           

gcc gtg aag atc ccc gag cag tgc acc ggt gac ctg ggt aag aaa ctg       1728
Ala Val Lys Ile Pro Glu Gln Cys Thr Gly Asp Leu Gly Lys Lys Leu           
                565                 570                 575               

ctg gaa gct gct cgt gct ggt cag gac gac gaa gtt cgt atc ctg atg       1776
Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp Glu Val Arg Ile Leu Met           
            580                 585                 590                   

gct aac ggt gct gac gtt aac gct aag gac gag tat ggt tct act ccg       1824
Ala Asn Gly Ala Asp Val Asn Ala Lys Asp Glu Tyr Gly Ser Thr Pro           
        595                 600                 605                       

ctg cac cta gct gct act ctt ggt cac ctg gaa atc gtt gaa gtt ctg       1872
Leu His Leu Ala Ala Thr Leu Gly His Leu Glu Ile Val Glu Val Leu           
    610                 615                 620                           

ctg aag cac ggt gct gac gtt aac gct gat gac gct act ggt ctt act       1920
Leu Lys His Gly Ala Asp Val Asn Ala Asp Asp Ala Thr Gly Leu Thr           
625                 630                 635                 640           

ccg ctg cac ctg gct gct tgg aat ggt cac ctg gag atc gtt gaa gtt       1968
Pro Leu His Leu Ala Ala Trp Asn Gly His Leu Glu Ile Val Glu Val           
                645                 650                 655               

ctg ctg aag tac ggt gct gac gtt aac gct atg gac ttt gag ggt tgg       2016
Leu Leu Lys Tyr Gly Ala Asp Val Asn Ala Met Asp Phe Glu Gly Trp           
            660                 665                 670                   

act ccg ctg cac ctg gct gct cat ttt ggt cac ctg gaa atc gtt gaa       2064
Thr Pro Leu His Leu Ala Ala His Phe Gly His Leu Glu Ile Val Glu           
        675                 680                 685                       

gtt ctg ctg aag tac ggt gct gac gtt aac gct cag gac aaa ttc ggt       2112
Val Leu Leu Lys Tyr Gly Ala Asp Val Asn Ala Gln Asp Lys Phe Gly           
    690                 695                 700                           

aag acc ccg ttc gac cta gcg atc gac aac ggt aac gag gac att gct       2160
Lys Thr Pro Phe Asp Leu Ala Ile Asp Asn Gly Asn Glu Asp Ile Ala           
705                 710                 715                 720           

gaa gtg ctg caa aaa gcg gcg aag ctt aat gcg gcc gca aga ggt tct       2208
Glu Val Leu Gln Lys Ala Ala Lys Leu Asn Ala Ala Ala Arg Gly Ser           
                725                 730                 735               

cat cac cat cac cat cac taa                                           2229
His His His His His His                                                   
            740                                                           


<210>  8
<211>  742
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  8

Met Lys Lys Ile Asn Glu Gly Leu Leu Asp Ser Lys Ile Leu Ser Ala 
1               5                   10                  15      


Phe Asn Thr Val Ile Ala Leu Leu Gly Ser Ile Val Ile Ile Val Met 
            20                  25                  30          


Asn Ile Met Ile Ile Gln Asn Tyr Thr Arg Ser Thr Asp Asn Gln Ala 
        35                  40                  45              


Val Ile Lys Asp Ala Leu Gln Gly Ile Gln Gln Gln Ile Lys Gly Leu 
    50                  55                  60                  


Ala Asp Lys Ile Gly Thr Glu Ile Gly Pro Lys Val Ser Leu Ile Asp 
65                  70                  75                  80  


Thr Ser Ser Thr Ile Thr Ile Pro Ala Asn Ile Gly Leu Leu Gly Ser 
                85                  90                  95      


Lys Ile Ser Gln Ser Thr Ala Ser Ile Asn Glu Asn Val Asn Glu Lys 
            100                 105                 110         


Cys Lys Phe Thr Leu Pro Pro Leu Lys Ile His Glu Cys Asn Ile Ser 
        115                 120                 125             


Cys Pro Asn Pro Leu Pro Phe Arg Glu Tyr Arg Pro Gln Thr Glu Gly 
    130                 135                 140                 


Val Ser Asn Leu Val Gly Leu Pro Asn Asn Ile Cys Leu Gln Lys Thr 
145                 150                 155                 160 


Ser Asn Gln Ile Leu Lys Pro Lys Leu Ile Ser Tyr Thr Leu Pro Val 
                165                 170                 175     


Val Gly Gln Ser Gly Thr Cys Ile Thr Asp Pro Leu Leu Ala Met Asp 
            180                 185                 190         


Glu Gly Tyr Phe Ala Tyr Ser His Leu Glu Arg Ile Gly Ser Cys Ser 
        195                 200                 205             


Arg Gly Val Ser Lys Gln Arg Ile Ile Gly Val Gly Glu Val Leu Asp 
    210                 215                 220                 


Arg Gly Asp Glu Val Pro Ser Leu Phe Met Thr Asn Val Trp Thr Pro 
225                 230                 235                 240 


Pro Asn Pro Asn Thr Val Tyr His Cys Ser Ala Val Tyr Asn Asn Glu 
                245                 250                 255     


Phe Tyr Tyr Val Leu Cys Ala Val Ser Thr Val Gly Asp Pro Ile Leu 
            260                 265                 270         


Asn Ser Thr Tyr Trp Ser Gly Ser Leu Met Met Thr Arg Leu Ala Val 
        275                 280                 285             


Lys Pro Lys Ser Asn Gly Gly Gly Tyr Asn Gln His Gln Leu Ala Leu 
    290                 295                 300                 


Arg Ser Ile Glu Lys Gly Arg Tyr Asp Lys Val Met Pro Tyr Gly Pro 
305                 310                 315                 320 


Ser Gly Ile Lys Gln Gly Asp Thr Leu Tyr Phe Pro Ala Val Gly Phe 
                325                 330                 335     


Leu Val Arg Thr Glu Phe Lys Tyr Asn Asp Ser Asn Cys Pro Ile Thr 
            340                 345                 350         


Lys Cys Gln Tyr Ser Lys Pro Glu Asn Cys Arg Leu Ser Met Gly Ile 
        355                 360                 365             


Arg Pro Asn Ser His Tyr Ile Leu Arg Ser Gly Leu Leu Lys Tyr Asn 
    370                 375                 380                 


Leu Ser Asp Gly Glu Asn Pro Lys Val Val Phe Ile Glu Ile Ser Asp 
385                 390                 395                 400 


Gln Arg Leu Ser Ile Gly Ser Pro Ser Lys Ile Tyr Asp Ser Leu Gly 
                405                 410                 415     


Gln Pro Val Phe Tyr Gln Ala Ser Phe Ser Trp Asp Thr Met Ile Lys 
            420                 425                 430         


Phe Gly Asp Val Leu Thr Val Asn Pro Leu Val Val Asn Trp Arg Asn 
        435                 440                 445             


Asn Thr Val Ile Ser Arg Pro Gly Gln Ser Gln Cys Pro Arg Phe Asn 
    450                 455                 460                 


Thr Cys Pro Ala Ile Cys Ala Glu Gly Val Tyr Asn Asp Ala Phe Leu 
465                 470                 475                 480 


Ile Asp Arg Ile Asn Trp Ile Ser Ala Gly Val Phe Leu Asp Ser Asn 
                485                 490                 495     


Ala Thr Ala Ala Asn Pro Val Phe Thr Val Phe Lys Asp Asn Glu Ile 
            500                 505                 510         


Leu Tyr Arg Ala Gln Leu Ala Ser Glu Asp Thr Asn Ala Gln Lys Thr 
        515                 520                 525             


Ile Thr Asn Cys Phe Leu Leu Lys Asn Lys Ile Trp Cys Ile Ser Leu 
    530                 535                 540                 


Val Glu Ile Tyr Asp Thr Gly Asp Asn Val Ile Arg Pro Lys Leu Phe 
545                 550                 555                 560 


Ala Val Lys Ile Pro Glu Gln Cys Thr Gly Asp Leu Gly Lys Lys Leu 
                565                 570                 575     


Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp Glu Val Arg Ile Leu Met 
            580                 585                 590         


Ala Asn Gly Ala Asp Val Asn Ala Lys Asp Glu Tyr Gly Ser Thr Pro 
        595                 600                 605             


Leu His Leu Ala Ala Thr Leu Gly His Leu Glu Ile Val Glu Val Leu 
    610                 615                 620                 


Leu Lys His Gly Ala Asp Val Asn Ala Asp Asp Ala Thr Gly Leu Thr 
625                 630                 635                 640 


Pro Leu His Leu Ala Ala Trp Asn Gly His Leu Glu Ile Val Glu Val 
                645                 650                 655     


Leu Leu Lys Tyr Gly Ala Asp Val Asn Ala Met Asp Phe Glu Gly Trp 
            660                 665                 670         


Thr Pro Leu His Leu Ala Ala His Phe Gly His Leu Glu Ile Val Glu 
        675                 680                 685             


Val Leu Leu Lys Tyr Gly Ala Asp Val Asn Ala Gln Asp Lys Phe Gly 
    690                 695                 700                 


Lys Thr Pro Phe Asp Leu Ala Ile Asp Asn Gly Asn Glu Asp Ile Ala 
705                 710                 715                 720 


Glu Val Leu Gln Lys Ala Ala Lys Leu Asn Ala Ala Ala Arg Gly Ser 
                725                 730                 735     


His His His His His His 
            740         


<210>  9
<211>  602
<212>  PRT
<213>  Nipah virus

<400>  9

Met Pro Ala Glu Asn Lys Lys Val Arg Phe Glu Asn Thr Thr Ser Asp 
1               5                   10                  15      


Lys Gly Lys Ile Pro Ser Lys Val Ile Lys Ser Tyr Tyr Gly Thr Met 
            20                  25                  30          


Asp Ile Lys Lys Ile Asn Glu Gly Leu Leu Asp Ser Lys Ile Leu Ser 
        35                  40                  45              


Ala Phe Asn Thr Val Ile Ala Leu Leu Gly Ser Ile Val Ile Ile Val 
    50                  55                  60                  


Met Asn Ile Met Ile Ile Gln Asn Tyr Thr Arg Ser Thr Asp Asn Gln 
65                  70                  75                  80  


Ala Val Ile Lys Asp Ala Leu Gln Gly Ile Gln Gln Gln Ile Lys Gly 
                85                  90                  95      


Leu Ala Asp Lys Ile Gly Thr Glu Ile Gly Pro Lys Val Ser Leu Ile 
            100                 105                 110         


Asp Thr Ser Ser Thr Ile Thr Ile Pro Ala Asn Ile Gly Leu Leu Gly 
        115                 120                 125             


Ser Lys Ile Ser Gln Ser Thr Ala Ser Ile Asn Glu Asn Val Asn Glu 
    130                 135                 140                 


Lys Cys Lys Phe Thr Leu Pro Pro Leu Lys Ile His Glu Cys Asn Ile 
145                 150                 155                 160 


Ser Cys Pro Asn Pro Leu Pro Phe Arg Glu Tyr Arg Pro Gln Thr Glu 
                165                 170                 175     


Gly Val Ser Asn Leu Val Gly Leu Pro Asn Asn Ile Cys Leu Gln Lys 
            180                 185                 190         


Thr Ser Asn Gln Ile Leu Lys Pro Lys Leu Ile Ser Tyr Thr Leu Pro 
        195                 200                 205             


Val Val Gly Gln Ser Gly Thr Cys Ile Thr Asp Pro Leu Leu Ala Met 
    210                 215                 220                 


Asp Glu Gly Tyr Phe Ala Tyr Ser His Leu Glu Arg Ile Gly Ser Cys 
225                 230                 235                 240 


Ser Arg Gly Val Ser Lys Gln Arg Ile Ile Gly Val Gly Glu Val Leu 
                245                 250                 255     


Asp Arg Gly Asp Glu Val Pro Ser Leu Phe Met Thr Asn Val Trp Thr 
            260                 265                 270         


Pro Pro Asn Pro Asn Thr Val Tyr His Cys Ser Ala Val Tyr Asn Asn 
        275                 280                 285             


Glu Phe Tyr Tyr Val Leu Cys Ala Val Ser Thr Val Gly Asp Pro Ile 
    290                 295                 300                 


Leu Asn Ser Thr Tyr Trp Ser Gly Ser Leu Met Met Thr Arg Leu Ala 
305                 310                 315                 320 


Val Lys Pro Lys Ser Asn Gly Gly Gly Tyr Asn Gln His Gln Leu Ala 
                325                 330                 335     


Leu Arg Ser Ile Glu Lys Gly Arg Tyr Asp Lys Val Met Pro Tyr Gly 
            340                 345                 350         


Pro Ser Gly Ile Lys Gln Gly Asp Thr Leu Tyr Phe Pro Ala Val Gly 
        355                 360                 365             


Phe Leu Val Arg Thr Glu Phe Lys Tyr Asn Asp Ser Asn Cys Pro Ile 
    370                 375                 380                 


Thr Lys Cys Gln Tyr Ser Lys Pro Glu Asn Cys Arg Leu Ser Met Gly 
385                 390                 395                 400 


Ile Arg Pro Asn Ser His Tyr Ile Leu Arg Ser Gly Leu Leu Lys Tyr 
                405                 410                 415     


Asn Leu Ser Asp Gly Glu Asn Pro Lys Val Val Phe Ile Glu Ile Ser 
            420                 425                 430         


Asp Gln Arg Leu Ser Ile Gly Ser Pro Ser Lys Ile Tyr Asp Ser Leu 
        435                 440                 445             


Gly Gln Pro Val Phe Tyr Gln Ala Ser Phe Ser Trp Asp Thr Met Ile 
    450                 455                 460                 


Lys Phe Gly Asp Val Leu Thr Val Asn Pro Leu Val Val Asn Trp Arg 
465                 470                 475                 480 


Asn Asn Thr Val Ile Ser Arg Pro Gly Gln Ser Gln Cys Pro Arg Phe 
                485                 490                 495     


Asn Thr Cys Pro Glu Ile Cys Trp Glu Gly Val Tyr Asn Asp Ala Phe 
            500                 505                 510         


Leu Ile Asp Arg Ile Asn Trp Ile Ser Ala Gly Val Phe Leu Asp Ser 
        515                 520                 525             


Asn Gln Thr Ala Glu Asn Pro Val Phe Thr Val Phe Lys Asp Asn Glu 
    530                 535                 540                 


Ile Leu Tyr Arg Ala Gln Leu Ala Ser Glu Asp Thr Asn Ala Gln Lys 
545                 550                 555                 560 


Thr Ile Thr Asn Cys Phe Leu Leu Lys Asn Lys Ile Trp Cys Ile Ser 
                565                 570                 575     


Leu Val Glu Ile Tyr Asp Thr Gly Asp Asn Val Ile Arg Pro Lys Leu 
            580                 585                 590         


Phe Ala Val Lys Ile Pro Glu Gln Cys Thr 
        595                 600         


<210>  10
<211>  617
<212>  PRT
<213>  Measles virus

<400>  10

Met Ser Pro Gln Arg Asp Arg Ile Asn Ala Phe Tyr Lys Asp Asn Pro 
1               5                   10                  15      


His Pro Lys Gly Ser Arg Ile Val Ile Asn Arg Glu His Leu Met Ile 
            20                  25                  30          


Asp Arg Pro Tyr Val Leu Leu Ala Val Leu Phe Val Met Phe Leu Ser 
        35                  40                  45              


Leu Ile Gly Leu Leu Ala Ile Ala Gly Ile Arg Leu His Arg Ala Ala 
    50                  55                  60                  


Ile Tyr Thr Ala Glu Ile His Lys Ser Leu Ser Thr Asn Leu Asp Val 
65                  70                  75                  80  


Thr Asn Ser Ile Glu His Gln Val Lys Asp Val Leu Thr Pro Leu Phe 
                85                  90                  95      


Lys Ile Ile Gly Asp Glu Val Gly Leu Arg Thr Pro Gln Arg Phe Thr 
            100                 105                 110         


Asp Leu Val Lys Phe Ile Ser Asp Lys Ile Lys Phe Leu Asn Pro Asp 
        115                 120                 125             


Arg Glu Tyr Asp Phe Arg Asp Leu Thr Trp Cys Ile Asn Pro Pro Glu 
    130                 135                 140                 


Arg Ile Lys Leu Asp Tyr Asp Gln Tyr Cys Ala Asp Val Ala Ala Glu 
145                 150                 155                 160 


Glu Leu Met Asn Ala Leu Val Asn Ser Thr Leu Leu Glu Thr Arg Thr 
                165                 170                 175     


Thr Asn Gln Phe Leu Ala Val Ser Lys Gly Asn Cys Ser Gly Pro Thr 
            180                 185                 190         


Thr Ile Arg Gly Gln Phe Ser Asn Met Ser Leu Ser Leu Leu Asp Leu 
        195                 200                 205             


Tyr Leu Gly Arg Gly Tyr Asn Val Ser Ser Ile Val Thr Met Thr Ser 
    210                 215                 220                 


Gln Gly Met Tyr Gly Gly Thr Tyr Leu Val Glu Lys Pro Asn Leu Ser 
225                 230                 235                 240 


Ser Lys Arg Ser Glu Leu Ser Gln Leu Ser Met Tyr Arg Val Phe Glu 
                245                 250                 255     


Val Gly Val Ile Arg Asn Pro Gly Leu Gly Ala Pro Val Phe His Met 
            260                 265                 270         


Thr Asn Tyr Leu Glu Gln Pro Val Ser Asn Asp Leu Ser Asn Cys Met 
        275                 280                 285             


Val Ala Leu Gly Glu Leu Lys Leu Ala Ala Leu Cys His Gly Glu Asp 
    290                 295                 300                 


Ser Ile Thr Ile Pro Tyr Gln Gly Ser Gly Lys Gly Val Ser Phe Gln 
305                 310                 315                 320 


Leu Val Lys Leu Gly Val Trp Lys Ser Pro Thr Asp Met Gln Ser Trp 
                325                 330                 335     


Val Pro Leu Ser Thr Asp Asp Pro Val Ile Asp Arg Leu Tyr Leu Ser 
            340                 345                 350         


Ser His Arg Gly Val Ile Ala Asp Asn Gln Ala Lys Trp Ala Val Pro 
        355                 360                 365             


Thr Thr Arg Thr Asp Asp Lys Leu Arg Met Glu Thr Cys Phe Gln Gln 
    370                 375                 380                 


Ala Cys Lys Gly Lys Ile Gln Ala Leu Cys Glu Asn Pro Glu Trp Ala 
385                 390                 395                 400 


Pro Leu Lys Asp Asn Arg Ile Pro Ser Tyr Gly Val Leu Ser Val Asp 
                405                 410                 415     


Leu Ser Leu Thr Val Glu Leu Lys Ile Lys Ile Ala Ser Gly Phe Gly 
            420                 425                 430         


Pro Leu Ile Thr His Gly Ser Gly Met Asp Leu Tyr Lys Ser Asn His 
        435                 440                 445             


Asn Asn Val Tyr Trp Leu Thr Ile Pro Pro Met Lys Asn Leu Ala Leu 
    450                 455                 460                 


Gly Val Ile Asn Thr Leu Glu Trp Ile Pro Arg Phe Lys Val Ser Pro 
465                 470                 475                 480 


Tyr Leu Phe Thr Val Pro Ile Lys Glu Ala Gly Gly Asp Cys His Ala 
                485                 490                 495     


Pro Thr Tyr Leu Pro Ala Glu Val Asp Gly Asp Val Lys Leu Ser Ser 
            500                 505                 510         


Asn Leu Val Ile Leu Pro Gly Gln Asp Leu Gln Tyr Val Leu Ala Thr 
        515                 520                 525             


Tyr Asp Thr Ser Arg Val Glu His Ala Val Val Tyr Tyr Val Tyr Ser 
    530                 535                 540                 


Pro Ser Arg Ser Phe Ser Tyr Phe Tyr Pro Phe Arg Leu Pro Ile Lys 
545                 550                 555                 560 


Gly Val Pro Ile Glu Leu Gln Val Glu Cys Phe Thr Trp Asp Gln Lys 
                565                 570                 575     


Leu Trp Cys Arg His Phe Cys Val Leu Ala Asp Ser Glu Ser Gly Gly 
            580                 585                 590         


His Ile Thr His Ser Gly Met Val Gly Met Gly Val Ser Cys Thr Val 
        595                 600                 605             


Thr Arg Glu Asp Gly Thr Asn Arg Arg 
    610                 615         


<210>  11
<211>  546
<212>  PRT
<213>  Nipah virus

<400>  11

Met Val Val Ile Leu Asp Lys Arg Cys Tyr Cys Asn Leu Leu Ile Leu 
1               5                   10                  15      


Ile Leu Met Ile Ser Glu Cys Ser Val Gly Ile Leu His Tyr Glu Lys 
            20                  25                  30          


Leu Ser Lys Ile Gly Leu Val Lys Gly Val Thr Arg Lys Tyr Lys Ile 
        35                  40                  45              


Lys Ser Asn Pro Leu Thr Lys Asp Ile Val Ile Lys Met Ile Pro Asn 
    50                  55                  60                  


Val Ser Asn Met Ser Gln Cys Thr Gly Ser Val Met Glu Asn Tyr Lys 
65                  70                  75                  80  


Thr Arg Leu Asn Gly Ile Leu Thr Pro Ile Lys Gly Ala Leu Glu Ile 
                85                  90                  95      


Tyr Lys Asn Asn Thr His Asp Leu Val Gly Asp Val Arg Leu Ala Gly 
            100                 105                 110         


Val Ile Met Ala Gly Val Ala Ile Gly Ile Ala Thr Ala Ala Gln Ile 
        115                 120                 125             


Thr Ala Gly Val Ala Leu Tyr Glu Ala Met Lys Asn Ala Asp Asn Ile 
    130                 135                 140                 


Asn Lys Leu Lys Ser Ser Ile Glu Ser Thr Asn Glu Ala Val Val Lys 
145                 150                 155                 160 


Leu Gln Glu Thr Ala Glu Lys Thr Val Tyr Val Leu Thr Ala Leu Gln 
                165                 170                 175     


Asp Tyr Ile Asn Thr Asn Leu Val Pro Thr Ile Asp Lys Ile Ser Cys 
            180                 185                 190         


Lys Gln Thr Glu Leu Ser Leu Asp Leu Ala Leu Ser Lys Tyr Leu Ser 
        195                 200                 205             


Asp Leu Leu Phe Val Phe Gly Pro Asn Leu Gln Asp Pro Val Ser Asn 
    210                 215                 220                 


Ser Met Thr Ile Gln Ala Ile Ser Gln Ala Phe Gly Gly Asn Tyr Glu 
225                 230                 235                 240 


Thr Leu Leu Arg Thr Leu Gly Tyr Ala Thr Glu Asp Phe Asp Asp Leu 
                245                 250                 255     


Leu Glu Ser Asp Ser Ile Thr Gly Gln Ile Ile Tyr Val Asp Leu Ser 
            260                 265                 270         


Ser Tyr Tyr Ile Ile Val Arg Val Tyr Phe Pro Ile Leu Thr Glu Ile 
        275                 280                 285             


Gln Gln Ala Tyr Ile Gln Glu Leu Leu Pro Val Ser Phe Asn Asn Asp 
    290                 295                 300                 


Asn Ser Glu Trp Ile Ser Ile Val Pro Asn Phe Ile Leu Val Arg Asn 
305                 310                 315                 320 


Thr Leu Ile Ser Asn Ile Glu Ile Gly Phe Cys Leu Ile Thr Lys Arg 
                325                 330                 335     


Ser Val Ile Cys Asn Gln Asp Tyr Ala Thr Pro Met Thr Asn Asn Met 
            340                 345                 350         


Arg Glu Cys Leu Thr Gly Ser Thr Glu Lys Cys Pro Arg Glu Leu Val 
        355                 360                 365             


Val Ser Ser His Val Pro Arg Phe Ala Leu Ser Asn Gly Val Leu Phe 
    370                 375                 380                 


Ala Asn Cys Ile Ser Val Thr Cys Gln Cys Gln Thr Thr Gly Arg Ala 
385                 390                 395                 400 


Ile Ser Gln Ser Gly Glu Gln Thr Leu Leu Met Ile Asp Asn Thr Thr 
                405                 410                 415     


Cys Pro Thr Ala Val Leu Gly Asn Val Ile Ile Ser Leu Gly Lys Tyr 
            420                 425                 430         


Leu Gly Ser Val Asn Tyr Asn Ser Glu Gly Ile Ala Ile Gly Pro Pro 
        435                 440                 445             


Val Phe Thr Asp Lys Val Asp Ile Ser Ser Gln Ile Ser Ser Met Asn 
    450                 455                 460                 


Gln Ser Leu Gln Gln Ser Lys Asp Tyr Ile Lys Glu Ala Gln Arg Leu 
465                 470                 475                 480 


Leu Asp Thr Val Asn Pro Ser Leu Ile Ser Met Leu Ser Met Ile Ile 
                485                 490                 495     


Leu Tyr Val Leu Ser Ile Ala Ser Leu Cys Ile Gly Leu Ile Thr Phe 
            500                 505                 510         


Ile Ser Phe Ile Ile Val Glu Lys Lys Arg Asn Thr Tyr Ser Arg Leu 
        515                 520                 525             


Glu Asp Arg Arg Val Arg Pro Thr Ser Ser Gly Asp Leu Tyr Tyr Ile 
    530                 535                 540                 


Gly Thr 
545     


<210>  12
<211>  553
<212>  PRT
<213>  Measles virus

<400>  12

Met Ser Ile Met Gly Leu Lys Val Asn Val Ser Ala Ile Phe Met Ala 
1               5                   10                  15      


Val Leu Leu Thr Leu Gln Thr Pro Thr Gly Gln Ile His Trp Gly Asn 
            20                  25                  30          


Leu Ser Lys Ile Gly Val Val Gly Ile Gly Ser Ala Ser Tyr Lys Val 
        35                  40                  45              


Met Thr Arg Ser Ser His Gln Ser Leu Val Ile Lys Leu Met Pro Asn 
    50                  55                  60                  


Ile Thr Leu Leu Asn Asn Cys Thr Arg Val Glu Ile Ala Glu Tyr Arg 
65                  70                  75                  80  


Arg Leu Leu Arg Thr Val Leu Glu Pro Ile Arg Asp Ala Leu Asn Ala 
                85                  90                  95      


Met Thr Gln Asn Ile Arg Pro Val Gln Ser Val Ala Ser Ser Arg Arg 
            100                 105                 110         


His Lys Arg Phe Ala Gly Val Val Leu Ala Gly Ala Ala Leu Gly Val 
        115                 120                 125             


Ala Thr Ala Ala Gln Ile Thr Ala Gly Ile Ala Leu His Gln Ser Met 
    130                 135                 140                 


Leu Asn Ser Gln Ala Ile Asp Asn Leu Arg Ala Ser Leu Glu Thr Thr 
145                 150                 155                 160 


Asn Gln Ala Ile Glu Ala Ile Arg Gln Ala Gly Gln Glu Met Ile Leu 
                165                 170                 175     


Ala Val Gln Gly Val Gln Asp Tyr Ile Asn Asn Glu Leu Ile Pro Ser 
            180                 185                 190         


Met Asn Gln Leu Ser Cys Asp Leu Ile Gly Gln Lys Leu Gly Leu Lys 
        195                 200                 205             


Leu Leu Arg Tyr Tyr Thr Glu Ile Leu Ser Leu Phe Gly Pro Ser Leu 
    210                 215                 220                 


Arg Asp Pro Ile Ser Ala Glu Ile Ser Ile Gln Ala Leu Ser Tyr Ala 
225                 230                 235                 240 


Leu Gly Gly Asp Ile Asn Lys Val Leu Glu Lys Leu Gly Tyr Ser Gly 
                245                 250                 255     


Gly Asp Leu Leu Gly Ile Leu Glu Ser Arg Gly Ile Lys Ala Arg Ile 
            260                 265                 270         


Thr His Val Asp Thr Glu Ser Tyr Phe Ile Val Leu Ser Ile Ala Tyr 
        275                 280                 285             


Pro Thr Leu Ser Glu Ile Lys Gly Val Ile Val His Arg Leu Glu Gly 
    290                 295                 300                 


Val Ser Tyr Asn Ile Gly Ser Gln Glu Trp Tyr Thr Thr Val Pro Lys 
305                 310                 315                 320 


Tyr Val Ala Thr Gln Gly Tyr Leu Ile Ser Asn Phe Asp Glu Ser Ser 
                325                 330                 335     


Cys Thr Phe Met Pro Glu Gly Thr Val Cys Ser Gln Asn Ala Leu Tyr 
            340                 345                 350         


Pro Met Ser Pro Leu Leu Gln Glu Cys Leu Arg Gly Ser Thr Lys Ser 
        355                 360                 365             


Cys Ala Arg Thr Leu Val Ser Gly Ser Phe Gly Asn Arg Phe Ile Leu 
    370                 375                 380                 


Ser Gln Gly Asn Leu Ile Ala Asn Cys Ala Ser Ile Leu Cys Lys Cys 
385                 390                 395                 400 


Tyr Thr Thr Gly Thr Ile Ile Asn Gln Asp Pro Asp Lys Ile Leu Thr 
                405                 410                 415     


Tyr Ile Ala Ala Asp His Cys Pro Val Val Glu Val Asn Gly Val Thr 
            420                 425                 430         


Ile Gln Val Gly Ser Arg Arg Tyr Pro Asp Ala Val Tyr Leu His Arg 
        435                 440                 445             


Ile Asp Leu Gly Pro Pro Ile Ser Leu Glu Arg Leu Asp Val Gly Thr 
    450                 455                 460                 


Asn Leu Gly Asn Ala Ile Ala Lys Leu Glu Asp Ala Lys Glu Leu Leu 
465                 470                 475                 480 


Glu Ser Ser Asp Gln Ile Leu Arg Ser Met Lys Gly Leu Ser Ser Thr 
                485                 490                 495     


Ser Ile Val Tyr Ile Leu Ile Ala Val Cys Leu Gly Gly Leu Ile Gly 
            500                 505                 510         


Ile Pro Ala Leu Ile Cys Cys Cys Arg Gly Arg Cys Asn Lys Lys Gly 
        515                 520                 525             


Glu Gln Val Gly Met Ser Arg Pro Gly Leu Lys Pro Asp Leu Thr Gly 
    530                 535                 540                 


Thr Ser Lys Ser Tyr Val Arg Ser Leu 
545                 550             


<210>  13
<211>  2328
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Truncated and mutated (Y481A, R533A, S548L, F549S) MeV H protein 
       (Hcdelta15) fused to IL-17


<220>
<221>  CDS
<222>  (1)..(2328)

<400>  13
atg cat ccc aag gga agt agg ata gtc att aac aga gaa cat ctt atg         48
Met His Pro Lys Gly Ser Arg Ile Val Ile Asn Arg Glu His Leu Met           
1               5                   10                  15                

att gat aga cct tat gtt ttg ctg gct gtt ctg ttt gtc atg ttt ctg         96
Ile Asp Arg Pro Tyr Val Leu Leu Ala Val Leu Phe Val Met Phe Leu           
            20                  25                  30                    

agc ttg atc ggg ttg cta gcc att gca ggc att aga ctt cat cgg gca        144
Ser Leu Ile Gly Leu Leu Ala Ile Ala Gly Ile Arg Leu His Arg Ala           
        35                  40                  45                        

gcc atc tac acc gca gag atc cat aaa agc ctc agc acc aat cta gat        192
Ala Ile Tyr Thr Ala Glu Ile His Lys Ser Leu Ser Thr Asn Leu Asp           
    50                  55                  60                            

gta act aac tca atc gag cat cag gtc aag gac gtg ctg aca cca ctc        240
Val Thr Asn Ser Ile Glu His Gln Val Lys Asp Val Leu Thr Pro Leu           
65                  70                  75                  80            

ttc aaa atc atc ggt gat gaa gtg ggc ctg agg aca cct cag aga ttc        288
Phe Lys Ile Ile Gly Asp Glu Val Gly Leu Arg Thr Pro Gln Arg Phe           
                85                  90                  95                

act gac cta gtg aaa ttc atc tct gac aag att aaa ttc ctt aat ccg        336
Thr Asp Leu Val Lys Phe Ile Ser Asp Lys Ile Lys Phe Leu Asn Pro           
            100                 105                 110                   

gat agg gag tac gac ttc aga gat ctc act tgg tgt atc aac ccg cca        384
Asp Arg Glu Tyr Asp Phe Arg Asp Leu Thr Trp Cys Ile Asn Pro Pro           
        115                 120                 125                       

gag aga atc aaa ttg gat tat gat caa tac tgt gca gat gtg gct gct        432
Glu Arg Ile Lys Leu Asp Tyr Asp Gln Tyr Cys Ala Asp Val Ala Ala           
    130                 135                 140                           

gaa gag ctc atg aat gca ttg gtg aac tca act cta ctg gag acc aga        480
Glu Glu Leu Met Asn Ala Leu Val Asn Ser Thr Leu Leu Glu Thr Arg           
145                 150                 155                 160           

aca acc aat cag ttc cta gct gtc tca aag gga aac tgc tca ggg ccc        528
Thr Thr Asn Gln Phe Leu Ala Val Ser Lys Gly Asn Cys Ser Gly Pro           
                165                 170                 175               

act aca atc aga ggt caa ttc tca aac atg tcg ctg tcc ctg tta gac        576
Thr Thr Ile Arg Gly Gln Phe Ser Asn Met Ser Leu Ser Leu Leu Asp           
            180                 185                 190                   

ttg tat tta ggt cga ggt tac aat gtg tca tct ata gtc act atg aca        624
Leu Tyr Leu Gly Arg Gly Tyr Asn Val Ser Ser Ile Val Thr Met Thr           
        195                 200                 205                       

tcc cag gga atg tat ggg gga act tac cta gtg gaa aag cct aat ctg        672
Ser Gln Gly Met Tyr Gly Gly Thr Tyr Leu Val Glu Lys Pro Asn Leu           
    210                 215                 220                           

agc agc aaa agg tca gag ttg tca caa ctg agc atg tac cga gtg ttt        720
Ser Ser Lys Arg Ser Glu Leu Ser Gln Leu Ser Met Tyr Arg Val Phe           
225                 230                 235                 240           

gaa gta ggt gtt atc aga aat ccg ggt ttg ggg gct ccg gtg ttc cat        768
Glu Val Gly Val Ile Arg Asn Pro Gly Leu Gly Ala Pro Val Phe His           
                245                 250                 255               

atg aca aac tat ctt gag caa cca gtc agt aat gat ctc agc aac tgt        816
Met Thr Asn Tyr Leu Glu Gln Pro Val Ser Asn Asp Leu Ser Asn Cys           
            260                 265                 270                   

atg gtg gct ttg ggg gag ctc aaa ctc gca gcc ctt tgt cac ggg gaa        864
Met Val Ala Leu Gly Glu Leu Lys Leu Ala Ala Leu Cys His Gly Glu           
        275                 280                 285                       

gat tct atc aca att ccc tat cag gga tca ggg aaa ggt gtc agc ttc        912
Asp Ser Ile Thr Ile Pro Tyr Gln Gly Ser Gly Lys Gly Val Ser Phe           
    290                 295                 300                           

cag ctc gtc aag cta ggt gtc tgg aaa tcc cca acc gac atg caa tcc        960
Gln Leu Val Lys Leu Gly Val Trp Lys Ser Pro Thr Asp Met Gln Ser           
305                 310                 315                 320           

tgg gtc ccc tta tca acg gat gat cca gtg ata gac agg ctt tac ctc       1008
Trp Val Pro Leu Ser Thr Asp Asp Pro Val Ile Asp Arg Leu Tyr Leu           
                325                 330                 335               

tca tct cac aga ggt gtt atc gct gac aat caa gca aaa tgg gct gtc       1056
Ser Ser His Arg Gly Val Ile Ala Asp Asn Gln Ala Lys Trp Ala Val           
            340                 345                 350                   

ccg aca aca cga aca gat gac aag ttg cga atg gag aca tgc ttc caa       1104
Pro Thr Thr Arg Thr Asp Asp Lys Leu Arg Met Glu Thr Cys Phe Gln           
        355                 360                 365                       

cag gcg tgt aag ggt aaa atc caa gca ctc tgc gag aat ccc gag tgg       1152
Gln Ala Cys Lys Gly Lys Ile Gln Ala Leu Cys Glu Asn Pro Glu Trp           
    370                 375                 380                           

gca cca ttg aag gat aac agg att cct tca tac ggg gtc ttg tct gtt       1200
Ala Pro Leu Lys Asp Asn Arg Ile Pro Ser Tyr Gly Val Leu Ser Val           
385                 390                 395                 400           

gat ctg agt ctg aca gtt gag ctt aaa atc aaa att gct tcg gga ttc       1248
Asp Leu Ser Leu Thr Val Glu Leu Lys Ile Lys Ile Ala Ser Gly Phe           
                405                 410                 415               

ggg cca ttg atc aca cac ggt tca ggg atg gac cta tac aaa tcc aac       1296
Gly Pro Leu Ile Thr His Gly Ser Gly Met Asp Leu Tyr Lys Ser Asn           
            420                 425                 430                   

cac aac aat gtg tat tgg ctg act atc ccg cca atg aag aac cta gcc       1344
His Asn Asn Val Tyr Trp Leu Thr Ile Pro Pro Met Lys Asn Leu Ala           
        435                 440                 445                       

tta ggt gta atc aac aca ttg gag tgg ata ccg aga ttc aag gtt agt       1392
Leu Gly Val Ile Asn Thr Leu Glu Trp Ile Pro Arg Phe Lys Val Ser           
    450                 455                 460                           

ccc gcg ctc ttc aat gtc cca att aag gaa gca ggc gaa gac tgc cat       1440
Pro Ala Leu Phe Asn Val Pro Ile Lys Glu Ala Gly Glu Asp Cys His           
465                 470                 475                 480           

gcc cca aca tac cta cct gcg gag gtg gat ggt gat gtc aaa ctc agt       1488
Ala Pro Thr Tyr Leu Pro Ala Glu Val Asp Gly Asp Val Lys Leu Ser           
                485                 490                 495               

tcc aat ctg gtg att cta cct ggt caa gat ctc caa tat gtt ttg gca       1536
Ser Asn Leu Val Ile Leu Pro Gly Gln Asp Leu Gln Tyr Val Leu Ala           
            500                 505                 510                   

acc tac gat act tcc gcg gtt gaa cat gct gtg gtt tat tac gtt tac       1584
Thr Tyr Asp Thr Ser Ala Val Glu His Ala Val Val Tyr Tyr Val Tyr           
        515                 520                 525                       

agc cca agc cgc tca ttt tct tac ttt tat cct ttt agg ttg cct ata       1632
Ser Pro Ser Arg Ser Phe Ser Tyr Phe Tyr Pro Phe Arg Leu Pro Ile           
    530                 535                 540                           

aag ggg gtc ccc atc gaa tta caa gtg gaa tgc ttc aca tgg gac caa       1680
Lys Gly Val Pro Ile Glu Leu Gln Val Glu Cys Phe Thr Trp Asp Gln           
545                 550                 555                 560           

aaa ctc tgg tgc cgt cac ttc tgt gtg ctt gcg gac tca gaa tct ggt       1728
Lys Leu Trp Cys Arg His Phe Cys Val Leu Ala Asp Ser Glu Ser Gly           
                565                 570                 575               

gga cat atc act cac tct ggg atg gag ggc atg gga gtc agc tgc aca       1776
Gly His Ile Thr His Ser Gly Met Glu Gly Met Gly Val Ser Cys Thr           
            580                 585                 590                   

gtc acc cgg gaa gat gga acc aat atc gag gga agg gcg gcc cag ccg       1824
Val Thr Arg Glu Asp Gly Thr Asn Ile Glu Gly Arg Ala Ala Gln Pro           
        595                 600                 605                       

gcc atg gcc gat tgt gat att gaa ggt aaa gat ggc aaa caa tat gag       1872
Ala Met Ala Asp Cys Asp Ile Glu Gly Lys Asp Gly Lys Gln Tyr Glu           
    610                 615                 620                           

agt gtt cta atg gtc agc atc gat caa tta ttg gac agc atg aaa gaa       1920
Ser Val Leu Met Val Ser Ile Asp Gln Leu Leu Asp Ser Met Lys Glu           
625                 630                 635                 640           

att ggt agc aat tgc ctg aat aat gaa ttt aac ttt ttt aaa aga cat       1968
Ile Gly Ser Asn Cys Leu Asn Asn Glu Phe Asn Phe Phe Lys Arg His           
                645                 650                 655               

atc tgt gat gct aat aag gaa ggt atg ttt tta ttc cgt gct gct cgc       2016
Ile Cys Asp Ala Asn Lys Glu Gly Met Phe Leu Phe Arg Ala Ala Arg           
            660                 665                 670                   

aag ttg agg caa ttt ctt aaa atg aat agc act ggt gat ttt gat ctc       2064
Lys Leu Arg Gln Phe Leu Lys Met Asn Ser Thr Gly Asp Phe Asp Leu           
        675                 680                 685                       

cac tta tta aaa gtt tca gaa ggc aca aca ata ctg ttg aac tgc act       2112
His Leu Leu Lys Val Ser Glu Gly Thr Thr Ile Leu Leu Asn Cys Thr           
    690                 695                 700                           

ggc cag gtt aaa gga aga aaa cca gct gcc ctg ggt gaa gcc caa cca       2160
Gly Gln Val Lys Gly Arg Lys Pro Ala Ala Leu Gly Glu Ala Gln Pro           
705                 710                 715                 720           

aca aag agt ttg gaa gaa aat aaa tct tta aag gaa cag aaa aaa ctg       2208
Thr Lys Ser Leu Glu Glu Asn Lys Ser Leu Lys Glu Gln Lys Lys Leu           
                725                 730                 735               

aat gac ttg tgt ttc cta aag aga cta tta caa gag ata aaa act tgt       2256
Asn Asp Leu Cys Phe Leu Lys Arg Leu Leu Gln Glu Ile Lys Thr Cys           
            740                 745                 750                   

tgg aat aaa att ttg atg ggc act aaa gaa cac gcg gcc gca aga gga       2304
Trp Asn Lys Ile Leu Met Gly Thr Lys Glu His Ala Ala Ala Arg Gly           
        755                 760                 765                       

tcg cat cac cat cac cat cac tga                                       2328
Ser His His His His His His                                               
    770                 775                                               


<210>  14
<211>  775
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  14

Met His Pro Lys Gly Ser Arg Ile Val Ile Asn Arg Glu His Leu Met 
1               5                   10                  15      


Ile Asp Arg Pro Tyr Val Leu Leu Ala Val Leu Phe Val Met Phe Leu 
            20                  25                  30          


Ser Leu Ile Gly Leu Leu Ala Ile Ala Gly Ile Arg Leu His Arg Ala 
        35                  40                  45              


Ala Ile Tyr Thr Ala Glu Ile His Lys Ser Leu Ser Thr Asn Leu Asp 
    50                  55                  60                  


Val Thr Asn Ser Ile Glu His Gln Val Lys Asp Val Leu Thr Pro Leu 
65                  70                  75                  80  


Phe Lys Ile Ile Gly Asp Glu Val Gly Leu Arg Thr Pro Gln Arg Phe 
                85                  90                  95      


Thr Asp Leu Val Lys Phe Ile Ser Asp Lys Ile Lys Phe Leu Asn Pro 
            100                 105                 110         


Asp Arg Glu Tyr Asp Phe Arg Asp Leu Thr Trp Cys Ile Asn Pro Pro 
        115                 120                 125             


Glu Arg Ile Lys Leu Asp Tyr Asp Gln Tyr Cys Ala Asp Val Ala Ala 
    130                 135                 140                 


Glu Glu Leu Met Asn Ala Leu Val Asn Ser Thr Leu Leu Glu Thr Arg 
145                 150                 155                 160 


Thr Thr Asn Gln Phe Leu Ala Val Ser Lys Gly Asn Cys Ser Gly Pro 
                165                 170                 175     


Thr Thr Ile Arg Gly Gln Phe Ser Asn Met Ser Leu Ser Leu Leu Asp 
            180                 185                 190         


Leu Tyr Leu Gly Arg Gly Tyr Asn Val Ser Ser Ile Val Thr Met Thr 
        195                 200                 205             


Ser Gln Gly Met Tyr Gly Gly Thr Tyr Leu Val Glu Lys Pro Asn Leu 
    210                 215                 220                 


Ser Ser Lys Arg Ser Glu Leu Ser Gln Leu Ser Met Tyr Arg Val Phe 
225                 230                 235                 240 


Glu Val Gly Val Ile Arg Asn Pro Gly Leu Gly Ala Pro Val Phe His 
                245                 250                 255     


Met Thr Asn Tyr Leu Glu Gln Pro Val Ser Asn Asp Leu Ser Asn Cys 
            260                 265                 270         


Met Val Ala Leu Gly Glu Leu Lys Leu Ala Ala Leu Cys His Gly Glu 
        275                 280                 285             


Asp Ser Ile Thr Ile Pro Tyr Gln Gly Ser Gly Lys Gly Val Ser Phe 
    290                 295                 300                 


Gln Leu Val Lys Leu Gly Val Trp Lys Ser Pro Thr Asp Met Gln Ser 
305                 310                 315                 320 


Trp Val Pro Leu Ser Thr Asp Asp Pro Val Ile Asp Arg Leu Tyr Leu 
                325                 330                 335     


Ser Ser His Arg Gly Val Ile Ala Asp Asn Gln Ala Lys Trp Ala Val 
            340                 345                 350         


Pro Thr Thr Arg Thr Asp Asp Lys Leu Arg Met Glu Thr Cys Phe Gln 
        355                 360                 365             


Gln Ala Cys Lys Gly Lys Ile Gln Ala Leu Cys Glu Asn Pro Glu Trp 
    370                 375                 380                 


Ala Pro Leu Lys Asp Asn Arg Ile Pro Ser Tyr Gly Val Leu Ser Val 
385                 390                 395                 400 


Asp Leu Ser Leu Thr Val Glu Leu Lys Ile Lys Ile Ala Ser Gly Phe 
                405                 410                 415     


Gly Pro Leu Ile Thr His Gly Ser Gly Met Asp Leu Tyr Lys Ser Asn 
            420                 425                 430         


His Asn Asn Val Tyr Trp Leu Thr Ile Pro Pro Met Lys Asn Leu Ala 
        435                 440                 445             


Leu Gly Val Ile Asn Thr Leu Glu Trp Ile Pro Arg Phe Lys Val Ser 
    450                 455                 460                 


Pro Ala Leu Phe Asn Val Pro Ile Lys Glu Ala Gly Glu Asp Cys His 
465                 470                 475                 480 


Ala Pro Thr Tyr Leu Pro Ala Glu Val Asp Gly Asp Val Lys Leu Ser 
                485                 490                 495     


Ser Asn Leu Val Ile Leu Pro Gly Gln Asp Leu Gln Tyr Val Leu Ala 
            500                 505                 510         


Thr Tyr Asp Thr Ser Ala Val Glu His Ala Val Val Tyr Tyr Val Tyr 
        515                 520                 525             


Ser Pro Ser Arg Ser Phe Ser Tyr Phe Tyr Pro Phe Arg Leu Pro Ile 
    530                 535                 540                 


Lys Gly Val Pro Ile Glu Leu Gln Val Glu Cys Phe Thr Trp Asp Gln 
545                 550                 555                 560 


Lys Leu Trp Cys Arg His Phe Cys Val Leu Ala Asp Ser Glu Ser Gly 
                565                 570                 575     


Gly His Ile Thr His Ser Gly Met Glu Gly Met Gly Val Ser Cys Thr 
            580                 585                 590         


Val Thr Arg Glu Asp Gly Thr Asn Ile Glu Gly Arg Ala Ala Gln Pro 
        595                 600                 605             


Ala Met Ala Asp Cys Asp Ile Glu Gly Lys Asp Gly Lys Gln Tyr Glu 
    610                 615                 620                 


Ser Val Leu Met Val Ser Ile Asp Gln Leu Leu Asp Ser Met Lys Glu 
625                 630                 635                 640 


Ile Gly Ser Asn Cys Leu Asn Asn Glu Phe Asn Phe Phe Lys Arg His 
                645                 650                 655     


Ile Cys Asp Ala Asn Lys Glu Gly Met Phe Leu Phe Arg Ala Ala Arg 
            660                 665                 670         


Lys Leu Arg Gln Phe Leu Lys Met Asn Ser Thr Gly Asp Phe Asp Leu 
        675                 680                 685             


His Leu Leu Lys Val Ser Glu Gly Thr Thr Ile Leu Leu Asn Cys Thr 
    690                 695                 700                 


Gly Gln Val Lys Gly Arg Lys Pro Ala Ala Leu Gly Glu Ala Gln Pro 
705                 710                 715                 720 


Thr Lys Ser Leu Glu Glu Asn Lys Ser Leu Lys Glu Gln Lys Lys Leu 
                725                 730                 735     


Asn Asp Leu Cys Phe Leu Lys Arg Leu Leu Gln Glu Ile Lys Thr Cys 
            740                 745                 750         


Trp Asn Lys Ile Leu Met Gly Thr Lys Glu His Ala Ala Ala Arg Gly 
        755                 760                 765             


Ser His His His His His His 
    770                 775 


<210>  15
<211>  523
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Truncated MeV fusion glycoprotein (FcDelta30)

<400>  15

Met Ser Ile Met Gly Leu Lys Val Asn Val Ser Ala Ile Phe Met Ala 
1               5                   10                  15      


Val Leu Leu Thr Leu Gln Thr Pro Thr Gly Gln Ile His Trp Gly Asn 
            20                  25                  30          


Leu Ser Lys Ile Gly Val Val Gly Ile Gly Ser Ala Ser Tyr Lys Val 
        35                  40                  45              


Met Thr Arg Ser Ser His Gln Ser Leu Val Ile Lys Leu Met Pro Asn 
    50                  55                  60                  


Ile Thr Leu Leu Asn Asn Cys Thr Arg Val Glu Ile Ala Glu Tyr Arg 
65                  70                  75                  80  


Arg Leu Leu Arg Thr Val Leu Glu Pro Ile Arg Asp Ala Leu Asn Ala 
                85                  90                  95      


Met Thr Gln Asn Ile Arg Pro Val Gln Ser Val Ala Ser Ser Arg Arg 
            100                 105                 110         


His Lys Arg Phe Ala Gly Val Val Leu Ala Gly Ala Ala Leu Gly Val 
        115                 120                 125             


Ala Thr Ala Ala Gln Ile Thr Ala Gly Ile Ala Leu His Gln Ser Met 
    130                 135                 140                 


Leu Asn Ser Gln Ala Ile Asp Asn Leu Arg Ala Ser Leu Glu Thr Thr 
145                 150                 155                 160 


Asn Gln Ala Ile Glu Ala Ile Arg Gln Ala Gly Gln Glu Met Ile Leu 
                165                 170                 175     


Ala Val Gln Gly Val Gln Asp Tyr Ile Asn Asn Glu Leu Ile Pro Ser 
            180                 185                 190         


Met Asn Gln Leu Ser Cys Asp Leu Ile Gly Gln Lys Leu Gly Leu Lys 
        195                 200                 205             


Leu Leu Arg Tyr Tyr Thr Glu Ile Leu Ser Leu Phe Gly Pro Ser Leu 
    210                 215                 220                 


Arg Asp Pro Ile Ser Ala Glu Ile Ser Ile Gln Ala Leu Ser Tyr Ala 
225                 230                 235                 240 


Leu Gly Gly Asp Ile Asn Lys Val Leu Glu Lys Leu Gly Tyr Ser Gly 
                245                 250                 255     


Gly Asp Leu Leu Gly Ile Leu Glu Ser Arg Gly Ile Lys Ala Arg Ile 
            260                 265                 270         


Thr His Val Asp Thr Glu Ser Tyr Phe Ile Val Leu Ser Ile Ala Tyr 
        275                 280                 285             


Pro Thr Leu Ser Glu Ile Lys Gly Val Ile Val His Arg Leu Glu Gly 
    290                 295                 300                 


Val Ser Tyr Asn Ile Gly Ser Gln Glu Trp Tyr Thr Thr Val Pro Lys 
305                 310                 315                 320 


Tyr Val Ala Thr Gln Gly Tyr Leu Ile Ser Asn Phe Asp Glu Ser Ser 
                325                 330                 335     


Cys Thr Phe Met Pro Glu Gly Thr Val Cys Ser Gln Asn Ala Leu Tyr 
            340                 345                 350         


Pro Met Ser Pro Leu Leu Gln Glu Cys Leu Arg Gly Ser Thr Lys Ser 
        355                 360                 365             


Cys Ala Arg Thr Leu Val Ser Gly Ser Phe Gly Asn Arg Phe Ile Leu 
    370                 375                 380                 


Ser Gln Gly Asn Leu Ile Ala Asn Cys Ala Ser Ile Leu Cys Lys Cys 
385                 390                 395                 400 


Tyr Thr Thr Gly Thr Ile Ile Asn Gln Asp Pro Asp Lys Ile Leu Thr 
                405                 410                 415     


Tyr Ile Ala Ala Asp His Cys Pro Val Val Glu Val Asn Gly Val Thr 
            420                 425                 430         


Ile Gln Val Gly Ser Arg Arg Tyr Pro Asp Ala Val Tyr Leu His Arg 
        435                 440                 445             


Ile Asp Leu Gly Pro Pro Ile Ser Leu Glu Arg Leu Asp Val Gly Thr 
    450                 455                 460                 


Asn Leu Gly Asn Ala Ile Ala Lys Leu Glu Asp Ala Lys Glu Leu Leu 
465                 470                 475                 480 


Glu Ser Ser Asp Gln Ile Leu Arg Ser Met Lys Gly Leu Ser Ser Thr 
                485                 490                 495     


Ser Ile Val Tyr Ile Leu Ile Ala Val Cys Leu Gly Gly Leu Ile Gly 
            500                 505                 510         


Ile Pro Ala Leu Ile Cys Cys Cys Arg Gly Arg 
        515                 520             


<210>  16
<211>  524
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Truncated NiV fusion glycoprotein (FcDelta22)

<400>  16

Met Val Val Ile Leu Asp Lys Arg Cys Tyr Cys Asn Leu Leu Ile Leu 
1               5                   10                  15      


Ile Leu Met Ile Ser Glu Cys Ser Val Gly Ile Leu His Tyr Glu Lys 
            20                  25                  30          


Leu Ser Lys Ile Gly Leu Val Lys Gly Val Thr Arg Lys Tyr Lys Ile 
        35                  40                  45              


Lys Ser Asn Pro Leu Thr Lys Asp Ile Val Ile Lys Met Ile Pro Asn 
    50                  55                  60                  


Val Ser Asn Met Ser Gln Cys Thr Gly Ser Val Met Glu Asn Tyr Lys 
65                  70                  75                  80  


Thr Arg Leu Asn Gly Ile Leu Thr Pro Ile Lys Gly Ala Leu Glu Ile 
                85                  90                  95      


Tyr Lys Asn Asn Thr His Asp Leu Val Gly Asp Val Arg Leu Ala Gly 
            100                 105                 110         


Val Ile Met Ala Gly Val Ala Ile Gly Ile Ala Thr Ala Ala Gln Ile 
        115                 120                 125             


Thr Ala Gly Val Ala Leu Tyr Glu Ala Met Lys Asn Ala Asp Asn Ile 
    130                 135                 140                 


Asn Lys Leu Lys Ser Ser Ile Glu Ser Thr Asn Glu Ala Val Val Lys 
145                 150                 155                 160 


Leu Gln Glu Thr Ala Glu Lys Thr Val Tyr Val Leu Thr Ala Leu Gln 
                165                 170                 175     


Asp Tyr Ile Asn Thr Asn Leu Val Pro Thr Ile Asp Lys Ile Ser Cys 
            180                 185                 190         


Lys Gln Thr Glu Leu Ser Leu Asp Leu Ala Leu Ser Lys Tyr Leu Ser 
        195                 200                 205             


Asp Leu Leu Phe Val Phe Gly Pro Asn Leu Gln Asp Pro Val Ser Asn 
    210                 215                 220                 


Ser Met Thr Ile Gln Ala Ile Ser Gln Ala Phe Gly Gly Asn Tyr Glu 
225                 230                 235                 240 


Thr Leu Leu Arg Thr Leu Gly Tyr Ala Thr Glu Asp Phe Asp Asp Leu 
                245                 250                 255     


Leu Glu Ser Asp Ser Ile Thr Gly Gln Ile Ile Tyr Val Asp Leu Ser 
            260                 265                 270         


Ser Tyr Tyr Ile Ile Val Arg Val Tyr Phe Pro Ile Leu Thr Glu Ile 
        275                 280                 285             


Gln Gln Ala Tyr Ile Gln Glu Leu Leu Pro Val Ser Phe Asn Asn Asp 
    290                 295                 300                 


Asn Ser Glu Trp Ile Ser Ile Val Pro Asn Phe Ile Leu Val Arg Asn 
305                 310                 315                 320 


Thr Leu Ile Ser Asn Ile Glu Ile Gly Phe Cys Leu Ile Thr Lys Arg 
                325                 330                 335     


Ser Val Ile Cys Asn Gln Asp Tyr Ala Thr Pro Met Thr Asn Asn Met 
            340                 345                 350         


Arg Glu Cys Leu Thr Gly Ser Thr Glu Lys Cys Pro Arg Glu Leu Val 
        355                 360                 365             


Val Ser Ser His Val Pro Arg Phe Ala Leu Ser Asn Gly Val Leu Phe 
    370                 375                 380                 


Ala Asn Cys Ile Ser Val Thr Cys Gln Cys Gln Thr Thr Gly Arg Ala 
385                 390                 395                 400 


Ile Ser Gln Ser Gly Glu Gln Thr Leu Leu Met Ile Asp Asn Thr Thr 
                405                 410                 415     


Cys Pro Thr Ala Val Leu Gly Asn Val Ile Ile Ser Leu Gly Lys Tyr 
            420                 425                 430         


Leu Gly Ser Val Asn Tyr Asn Ser Glu Gly Ile Ala Ile Gly Pro Pro 
        435                 440                 445             


Val Phe Thr Asp Lys Val Asp Ile Ser Ser Gln Ile Ser Ser Met Asn 
    450                 455                 460                 


Gln Ser Leu Gln Gln Ser Lys Asp Tyr Ile Lys Glu Ala Gln Arg Leu 
465                 470                 475                 480 


Leu Asp Thr Val Asn Pro Ser Leu Ile Ser Met Leu Ser Met Ile Ile 
                485                 490                 495     


Leu Tyr Val Leu Ser Ile Ala Ser Leu Cys Ile Gly Leu Ile Thr Phe 
            500                 505                 510         


Ile Ser Phe Ile Ile Val Glu Lys Lys Arg Asn Thr 
        515                 520                 


