                         SEQUENCE LISTING

<110>  CSL Limited
       B Creative Sweden AB
 
<120>  Method of treating or preventing liver conditions

<130>  525380

<150>  AU 2016901494
<151>  2016-04-21

<150>  AU 2016901483
<151>  2016-04-21

<160>  46    

<170>  PatentIn version 3.5

<210>  1
<211>  207
<212>  PRT
<213>  Homo sapiens


<220>
<221>  SIGNAL
<222>  (1)..(21)
<223>  Signal sequence

<400>  1

Met Ser Pro Leu Leu Arg Arg Leu Leu Leu Ala Ala Leu Leu Gln Leu 
1               5                   10                  15      


Ala Pro Ala Gln Ala Pro Val Ser Gln Pro Asp Ala Pro Gly His Gln 
            20                  25                  30          


Arg Lys Val Val Ser Trp Ile Asp Val Tyr Thr Arg Ala Thr Cys Gln 
        35                  40                  45              


Pro Arg Glu Val Val Val Pro Leu Thr Val Glu Leu Met Gly Thr Val 
    50                  55                  60                  


Ala Lys Gln Leu Val Pro Ser Cys Val Thr Val Gln Arg Cys Gly Gly 
65                  70                  75                  80  


Cys Cys Pro Asp Asp Gly Leu Glu Cys Val Pro Thr Gly Gln His Gln 
                85                  90                  95      


Val Arg Met Gln Ile Leu Met Ile Arg Tyr Pro Ser Ser Gln Leu Gly 
            100                 105                 110         


Glu Met Ser Leu Glu Glu His Ser Gln Cys Glu Cys Arg Pro Lys Lys 
        115                 120                 125             


Lys Asp Ser Ala Val Lys Pro Asp Arg Ala Ala Thr Pro His His Arg 
    130                 135                 140                 


Pro Gln Pro Arg Ser Val Pro Gly Trp Asp Ser Ala Pro Gly Ala Pro 
145                 150                 155                 160 


Ser Pro Ala Asp Ile Thr His Pro Thr Pro Ala Pro Gly Pro Ser Ala 
                165                 170                 175     


His Ala Ala Pro Ser Thr Thr Ser Ala Leu Thr Pro Gly Pro Ala Ala 
            180                 185                 190         


Ala Ala Ala Asp Ala Ala Ala Ser Ser Val Ala Lys Gly Gly Ala 
        195                 200                 205         


<210>  2
<211>  188
<212>  PRT
<213>  Homo sapiens


<220>
<221>  SIGNAL
<222>  (1)..(21)
<223>  Signal sequence

<400>  2

Met Ser Pro Leu Leu Arg Arg Leu Leu Leu Ala Ala Leu Leu Gln Leu 
1               5                   10                  15      


Ala Pro Ala Gln Ala Pro Val Ser Gln Pro Asp Ala Pro Gly His Gln 
            20                  25                  30          


Arg Lys Val Val Ser Trp Ile Asp Val Tyr Thr Arg Ala Thr Cys Gln 
        35                  40                  45              


Pro Arg Glu Val Val Val Pro Leu Thr Val Glu Leu Met Gly Thr Val 
    50                  55                  60                  


Ala Lys Gln Leu Val Pro Ser Cys Val Thr Val Gln Arg Cys Gly Gly 
65                  70                  75                  80  


Cys Cys Pro Asp Asp Gly Leu Glu Cys Val Pro Thr Gly Gln His Gln 
                85                  90                  95      


Val Arg Met Gln Ile Leu Met Ile Arg Tyr Pro Ser Ser Gln Leu Gly 
            100                 105                 110         


Glu Met Ser Leu Glu Glu His Ser Gln Cys Glu Cys Arg Pro Lys Lys 
        115                 120                 125             


Lys Asp Ser Ala Val Lys Pro Asp Ser Pro Arg Pro Leu Cys Pro Arg 
    130                 135                 140                 


Cys Thr Gln His His Gln Arg Pro Asp Pro Arg Thr Cys Arg Arg Arg 
145                 150                 155                 160 


Cys Arg Arg Arg Ser Phe Leu Arg Cys Gln Gly Arg Gly Leu Glu Leu 
                165                 170                 175     


Asn Pro Asp Thr Cys Arg Cys Arg Lys Leu Arg Arg 
            180                 185             


<210>  3
<211>  119
<212>  PRT
<213>  artificial

<220>
<223>  amino acid sequence from a VH of antibody 2H10

<400>  3

Val Gln Leu Gln Gln Pro Gly Thr Glu Leu Val Lys Pro Gly Ala Ser 
1               5                   10                  15      


Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Phe Trp 
            20                  25                  30          


Ile His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile Gly 
        35                  40                  45              


His Ile Asn Pro Gly Asn Gly Gly Thr Asn Tyr Asn Glu Lys Phe Lys 
    50                  55                  60                  


Arg Met Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met 
65                  70                  75                  80  


Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Ser Tyr Ser Asn Tyr Val Arg Ala Met Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Ser Val Thr Val Ser Ser 
        115                 


<210>  4
<211>  106
<212>  PRT
<213>  artificial

<220>
<223>  amino acid sequence from a VL of antibody 2H10

<400>  4

Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly Asp 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Asn Phe Leu 
            20                  25                  30          


Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile Tyr 
        35                  40                  45              


Tyr Thr Ser Thr Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln Glu 
65                  70                  75                  80  


Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Lys Thr Leu Pro Pro Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105     


<210>  5
<211>  119
<212>  PRT
<213>  artificial

<220>
<223>  amino acid sequence from a VH of a humanized form of antibody 
       2H10

<400>  5

Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser 
1               5                   10                  15      


Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Phe Trp 
            20                  25                  30          


Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly 
        35                  40                  45              


His Ile Asn Pro Gly Asn Gly Gly Thr Asn Tyr Asn Glu Lys Phe Lys 
    50                  55                  60                  


Arg Arg Val Thr Met Thr Arg Asp Lys Ser Ile Ser Thr Ala Tyr Met 
65                  70                  75                  80  


Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Ser Tyr Ser Asn Tyr Val Arg Ala Met Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  6
<211>  107
<212>  PRT
<213>  artificial

<220>
<223>  amino acid sequence of a VL of a humanized form of antibody 2H10

<400>  6

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Ser Asn Phe 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Thr Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Lys Thr Leu Pro Pro 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  7
<211>  116
<212>  PRT
<213>  artificial

<220>
<223>  amino acid sequence from a VH of antibody 4E12

<400>  7

Val Gln Pro Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala Ser 
1               5                   10                  15      


Val Lys Met Ser Cys Lys Ala Ser Gly Asp Thr Phe Thr Asn Ser Trp 
            20                  25                  30          


Ile Gly Trp Val Thr Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile Gly 
        35                  40                  45              


Asp Ile Phe Pro Gly Ser Gly His Thr Asn Tyr Asn Glu Lys Phe Lys 
    50                  55                  60                  


Asn Arg Ala Thr Leu Thr Val Asp Thr Ser Ser Ser Thr Ala Tyr Met 
65                  70                  75                  80  


Leu Leu Ser Ser Leu Thr Ser Asp Asp Ser Ala Val Tyr Tyr Cys Val 
                85                  90                  95      


Ile Glu Asn Tyr Ala Trp Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ala 
        115     


<210>  8
<211>  107
<212>  PRT
<213>  artificial

<220>
<223>  amino acid sequence of a VL of antibody 4E12

<400>  8

Asp Ile Val Met Thr Gln Ser Gln Lys Phe Met Ser Ser Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Val Thr Cys Lys Ala Ser Gln Asn Val Asn Thr Asn 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Gln Gly Gln Ser Pro Arg Pro Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Ser Arg Cys Ser Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Phe Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Val Gln Ser 
65                  70                  75                  80  


Glu Asp Leu Ala Glu Tyr Phe Cys Gln Gln Tyr His Ser Phe Pro Leu 
                85                  90                  95      


Thr Phe Gly Ala Gly Ala Lys Leu Asp Leu Lys 
            100                 105         


<210>  9
<211>  118
<212>  PRT
<213>  artificial

<220>
<223>  amino acid sequence from a VH of antibody 2F5

<400>  9

Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Thr Ser 
1               5                   10                  15      


Val Arg Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Thr Phe Tyr 
            20                  25                  30          


Ile His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile Gly 
        35                  40                  45              


Trp Phe Tyr Pro Gly Asn Val Asn Thr Asn Tyr Asn Glu Lys Leu Lys 
    50                  55                  60                  


Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Ala Ala Tyr Leu 
65                  70                  75                  80  


Gln Leu Asn Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys Thr 
                85                  90                  95      


Arg Ser Pro Tyr Tyr Gly Tyr Val Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Leu Thr Val Ser Ser 
        115             


<210>  10
<211>  107
<212>  PRT
<213>  artificial

<220>
<223>  amino acid sequence of a VL of antibody 2F5

<400>  10

Asp Ile Val Met Thr Gln Ser His Lys Phe Met Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asp Val Gly Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Val Gln Ser 
65                  70                  75                  80  


Glu Asp Leu Ala Asp Tyr Phe Cys Gln Gln Tyr Ser Ser Ser Leu Thr 
                85                  90                  95      


Phe Gly Ala Gly Ala Thr Lys Leu Glu Leu Lys 
            100                 105         


<210>  11
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence of 2H10 VL CDR1

<400>  11
agggcaagtc aggacattag caatttttta aac                                    33


<210>  12
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence of 2H10 VL CDR2

<400>  12
tacacatcaa cattacactc a                                                 21


<210>  13
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence of 2H10 VL CDR3

<400>  13
caacagggta aaacgcttcc tcccacg                                           27


<210>  14
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence of 2H10 VH CDR1

<400>  14
ggctacactt tcactggctt ctggatacac                                        30


<210>  15
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence of 2H10 VH CDR2

<400>  15
catattaatc ctggcaatgg tggcactaac tacaatgaga agttcaagag a                51


<210>  16
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence of 2H10 VH CDR3

<400>  16
tcctatagta actacgtgcg ggctatggac tac                                    33


<210>  17
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of 2H10 VL CDR1

<400>  17

Arg Ala Ser Gln Asp Ile Ser Asn Phe Leu Asn 
1               5                   10      


<210>  18
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of 2H10 VL CDR2

<400>  18

Tyr Thr Ser Thr Leu His Ser 
1               5           


<210>  19
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of 2H10 VL CDR3

<400>  19

Gln Gln Gly Lys Thr Leu Pro Pro Thr 
1               5                   


<210>  20
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of 2H10 VH CDR1

<400>  20

Gly Tyr Thr Phe Thr Gly Phe Trp Ile His 
1               5                   10  


<210>  21
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of 2H10 VH CDR2

<400>  21

His Ile Asn Pro Gly Asn Gly Gly Thr Asn Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Arg 
    


<210>  22
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of 2H10 VH CDR3

<400>  22

Ser Tyr Ser Asn Tyr Val Arg Ala Met Asp Tyr 
1               5                   10      


<210>  23
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleotide sequence of 2F5 VL CDR1

<400>  23
aaggccagtc aggatgtggg tactgctgta gcc                                    33


<210>  24
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleotide sequence of 2F5 VL CDR2

<400>  24
tgggcatcca cccggcacac t                                                 21


<210>  25
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleotide sequence of 2F5 VL CDR3

<400>  25
caacaatata gcagctctct cacg                                              24


<210>  26
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleotide sequence of 2F5 VH CDR1

<400>  26
ggctacacct tcacaacctt ctatatacac                                        30


<210>  27
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleotide sequence of 2F5 VH CDR2

<400>  27
tggttttatc ctggaaatgt taataccaac tacaatgaga agctcaaggg c                51


<210>  28
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleotide sequence of 2F5 VH CDR3

<400>  28
tccccttact acggctacgt ttttgactac                                        30


<210>  29
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of 2F5 VL CDR1

<400>  29

Lys Ala Ser Gln Asp Val Gly Thr Ala Val Ala 
1               5                   10      


<210>  30
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of 2F5 VL CDR2

<400>  30

Trp Ala Ser Thr Arg His Thr 
1               5           


<210>  31
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of 2F5 VL CDR3

<400>  31

Gln Gln Tyr Ser Ser Ser Leu Thr 
1               5               


<210>  32
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of 2F5 VH CDR1

<400>  32

Gly Tyr Thr Phe Thr Thr Phe Tyr Ile His 
1               5                   10  


<210>  33
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of 2F5 VH CDR2

<400>  33

Trp Phe Tyr Pro Gly Asn Val Asn Thr Asn Tyr Asn Glu Lys Leu Lys 
1               5                   10                  15      


Gly 
    


<210>  34
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of 2F5 VH CDR3

<400>  34

Ser Pro Tyr Tyr Gly Tyr Val Phe Asp Tyr 
1               5                   10  


<210>  35
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleotide sequence of 4E12 VL CDR1

<400>  35
aaggccagtc agaatgtgaa cactaatgta gcc                                    33


<210>  36
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleotide sequence of 4E12 VL CDR2

<400>  36
tcggcatcct cccggtgcag t                                                 21


<210>  37
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleotide sequence of 4E12 VL CDR3

<400>  37
cagcaatatc acagctttcc gctcacg                                           27


<210>  38
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleotide sequence of 4E12 VH CDR1

<400>  38
ggcgacacct tcaccaactc ctggataggc                                        30


<210>  39
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleotide sequence of 4E12 VH CDR2

<400>  39
gatatttttc ctgggagtgg tcatactaac tacaatgaga agttcaagaa c                51


<210>  40
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleotide sequence of 4E12 VH CDR3

<400>  40
gagaattatg cctggtttgc ttat                                              24


<210>  41
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of 4E12 VL CDR1

<400>  41

Lys Ala Ser Gln Asn Val Asn Thr Asn Val Ala 
1               5                   10      


<210>  42
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of 4E12 VL CDR2

<400>  42

Ser Ala Ser Ser Arg Cys Ser 
1               5           


<210>  43
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of 4E12 VL CDR3

<400>  43

Gln Gln Tyr His Ser Phe Pro Leu Thr 
1               5                   


<210>  44
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of 4E12 VH CDR1

<400>  44

Gly Asp Thr Phe Thr Asn Ser Trp Ile Gly 
1               5                   10  


<210>  45
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of 4E12 VH CDR2

<400>  45

Asp Ile Phe Pro Gly Ser Gly His Thr Asn Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Asn 
    


<210>  46
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of 4E12 VH CDR3

<400>  46

Glu Asn Tyr Ala Trp Phe Ala Tyr 
1               5               


