                         SEQUENCE LISTING

<110>  Iconic Therapeutics, Inc.
       Migone, Thi-Sau
       Theunissen, Jan-Willem F.A.S.
 
<120>  MODIFIED HUMAN IMMUNOCONJUGATE PROTEINS

<130>  ICTH-003/01WO 321838-2011

<150>  62/322,540
<151>  2016-04-14

<160>  59    

<170>  PatentIn version 3.5

<210>  1
<211>  444
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Val Ser Gln Ala Leu Arg Leu Leu Cys Leu Leu Leu Gly Leu Gln 
1               5                   10                  15      


Gly Cys Leu Ala Ala Val Phe Val Thr Gln Glu Glu Ala His Gly Val 
            20                  25                  30          


Leu His Arg Arg Arg Arg Ala Asn Ala Phe Leu Glu Glu Leu Arg Pro 
        35                  40                  45              


Gly Ser Leu Glu Arg Glu Cys Lys Glu Glu Gln Cys Ser Phe Glu Glu 
    50                  55                  60                  


Ala Arg Glu Ile Phe Lys Asp Ala Glu Arg Thr Lys Leu Phe Trp Ile 
65                  70                  75                  80  


Ser Tyr Ser Asp Gly Asp Gln Cys Ala Ser Ser Pro Cys Gln Asn Gly 
                85                  90                  95      


Gly Ser Cys Lys Asp Gln Leu Gln Ser Tyr Ile Cys Phe Cys Leu Pro 
            100                 105                 110         


Ala Phe Glu Gly Arg Asn Cys Glu Thr His Lys Asp Asp Gln Leu Ile 
        115                 120                 125             


Cys Val Asn Glu Asn Gly Gly Cys Glu Gln Tyr Cys Ser Asp His Thr 
    130                 135                 140                 


Gly Thr Lys Arg Ser Cys Arg Cys His Glu Gly Tyr Ser Leu Leu Ala 
145                 150                 155                 160 


Asp Gly Val Ser Cys Thr Pro Thr Val Glu Tyr Pro Cys Gly Lys Ile 
                165                 170                 175     


Pro Ile Leu Glu Lys Arg Asn Ala Ser Lys Pro Gln Gly Arg Ile Val 
            180                 185                 190         


Gly Gly Lys Val Cys Pro Lys Gly Glu Cys Pro Trp Gln Val Leu Leu 
        195                 200                 205             


Leu Val Asn Gly Ala Gln Leu Cys Gly Gly Thr Leu Ile Asn Thr Ile 
    210                 215                 220                 


Trp Val Val Ser Ala Ala His Cys Phe Asp Lys Ile Lys Asn Trp Arg 
225                 230                 235                 240 


Asn Leu Ile Ala Val Leu Gly Glu His Asp Leu Ser Glu His Asp Gly 
                245                 250                 255     


Asp Glu Gln Ser Arg Arg Val Ala Gln Val Ile Ile Pro Ser Thr Tyr 
            260                 265                 270         


Val Pro Gly Thr Thr Asn His Asp Ile Ala Leu Leu Arg Leu His Gln 
        275                 280                 285             


Pro Val Val Leu Thr Asp His Val Val Pro Leu Cys Leu Pro Glu Arg 
    290                 295                 300                 


Thr Phe Ser Glu Arg Thr Leu Ala Phe Val Arg Phe Ser Leu Val Ser 
305                 310                 315                 320 


Gly Trp Gly Gln Leu Leu Asp Arg Gly Ala Thr Ala Leu Glu Leu Met 
                325                 330                 335     


Val Leu Asn Val Pro Arg Leu Met Thr Gln Asp Cys Leu Gln Gln Ser 
            340                 345                 350         


Arg Lys Val Gly Asp Ser Pro Asn Ile Thr Glu Tyr Met Phe Cys Ala 
        355                 360                 365             


Gly Tyr Ser Asp Gly Ser Lys Asp Ser Cys Lys Gly Asp Ser Gly Gly 
    370                 375                 380                 


Pro His Ala Thr His Tyr Arg Gly Thr Trp Tyr Leu Thr Gly Ile Val 
385                 390                 395                 400 


Ser Trp Gly Gln Gly Cys Ala Thr Val Gly His Phe Gly Val Tyr Thr 
                405                 410                 415     


Arg Val Ser Gln Tyr Ile Glu Trp Leu Gln Lys Leu Met Arg Ser Glu 
            420                 425                 430         


Pro Arg Pro Gly Val Leu Leu Arg Ala Pro Phe Pro 
        435                 440                 


<210>  2
<211>  406
<212>  PRT
<213>  Homo sapiens

<400>  2

Ala Asn Ala Phe Leu Glu Glu Leu Arg Pro Gly Ser Leu Glu Arg Glu 
1               5                   10                  15      


Cys Lys Glu Glu Gln Cys Ser Phe Glu Glu Ala Arg Glu Ile Phe Lys 
            20                  25                  30          


Asp Ala Glu Arg Thr Lys Leu Phe Trp Ile Ser Tyr Ser Asp Gly Asp 
        35                  40                  45              


Gln Cys Ala Ser Ser Pro Cys Gln Asn Gly Gly Ser Cys Lys Asp Gln 
    50                  55                  60                  


Leu Gln Ser Tyr Ile Cys Phe Cys Leu Pro Ala Phe Glu Gly Arg Asn 
65                  70                  75                  80  


Cys Glu Thr His Lys Asp Asp Gln Leu Ile Cys Val Asn Glu Asn Gly 
                85                  90                  95      


Gly Cys Glu Gln Tyr Cys Ser Asp His Thr Gly Thr Lys Arg Ser Cys 
            100                 105                 110         


Arg Cys His Glu Gly Tyr Ser Leu Leu Ala Asp Gly Val Ser Cys Thr 
        115                 120                 125             


Pro Thr Val Glu Tyr Pro Cys Gly Lys Ile Pro Ile Leu Glu Lys Arg 
    130                 135                 140                 


Asn Ala Ser Lys Pro Gln Gly Arg Ile Val Gly Gly Lys Val Cys Pro 
145                 150                 155                 160 


Lys Gly Glu Cys Pro Trp Gln Val Leu Leu Leu Val Asn Gly Ala Gln 
                165                 170                 175     


Leu Cys Gly Gly Thr Leu Ile Asn Thr Ile Trp Val Val Ser Ala Ala 
            180                 185                 190         


His Cys Phe Asp Lys Ile Lys Asn Trp Arg Asn Leu Ile Ala Val Leu 
        195                 200                 205             


Gly Glu His Asp Leu Ser Glu His Asp Gly Asp Glu Gln Ser Arg Arg 
    210                 215                 220                 


Val Ala Gln Val Ile Ile Pro Ser Thr Tyr Val Pro Gly Thr Thr Asn 
225                 230                 235                 240 


His Asp Ile Ala Leu Leu Arg Leu His Gln Pro Val Val Leu Thr Asp 
                245                 250                 255     


His Val Val Pro Leu Cys Leu Pro Glu Arg Thr Phe Ser Glu Arg Thr 
            260                 265                 270         


Leu Ala Phe Val Arg Phe Ser Leu Val Ser Gly Trp Gly Gln Leu Leu 
        275                 280                 285             


Asp Arg Gly Ala Thr Ala Leu Glu Leu Met Val Leu Asn Val Pro Arg 
    290                 295                 300                 


Leu Met Thr Gln Asp Cys Leu Gln Gln Ser Arg Lys Val Gly Asp Ser 
305                 310                 315                 320 


Pro Asn Ile Thr Glu Tyr Met Phe Cys Ala Gly Tyr Ser Asp Gly Ser 
                325                 330                 335     


Lys Asp Ser Cys Lys Gly Asp Ser Gly Gly Pro His Ala Thr His Tyr 
            340                 345                 350         


Arg Gly Thr Trp Tyr Leu Thr Gly Ile Val Ser Trp Gly Gln Gly Cys 
        355                 360                 365             


Ala Thr Val Gly His Phe Gly Val Tyr Thr Arg Val Ser Gln Tyr Ile 
    370                 375                 380                 


Glu Trp Leu Gln Lys Leu Met Arg Ser Glu Pro Arg Pro Gly Val Leu 
385                 390                 395                 400 


Leu Arg Ala Pro Phe Pro 
                405     


<210>  3
<211>  2072
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Homo sapiens factor VII active site mutant immunoconjugate mRNA, 
       complete CDS; NCBI Accession AF272774

<400>  3
aagctttgca gagatttcat catggtctcc caggccctca ggctcctctg ccttctgctt       60

gggcttcagg gctgcctggc tgcagtcttc gtaacccagg aggaagccca cggcgtcctg      120

caccggcgcc ggcgcgccaa cgcgttcctg gaggagctgc ggccgggctc cctggagagg      180

gagtgcaagg aggagcagtg ctccttcgag gaggcccggg agatcttcaa ggacgcggag      240

aggacgaagc tgttctggat ttcttacagt gatggtgacc agtgtgcctc aagtccatgc      300

cagaatgggg gctcctgcaa ggaccagctc cagtcctata tctgcttctg cctccctgcc      360

ttcgagggcc ggaactgtga gacgcacaag gatgaccagc tgatctgtgt gaacgagaac      420

ggcggctgtg agcagtactg cagtgaccac acgggcacca agcgctcctg tcggtgccac      480

gaggggtact ctctgctggc agacggggtg tcctgcacac ccacagttga atatccatgt      540

ggaaaaatac ctattctaga aaaaagaaat gccagcaagc cccaagggcg aattgtgggg      600

ggcaaggtgt gccccaaagg ggagtgtcca tggcaggtcc tgttgttggt gaatggagct      660

cagttgtgtg gggggaccct gatcaacacc atctgggtgg tctccgcggc ccactgtttc      720

gacaaaatca agaactggag gaacctgatc gcggtgctcg gggagcacga cctcagcgag      780

cacgacgggg atgagcagag ccggcgggtg gcgcaggtca tcatccccag cacgtacgtc      840

ccgggcacca ccaaccacga catcgcgctg ctccgcctgc accagcccgt ggtcctcact      900

gaccatgtgg tgcccctctg cctgcccgaa cggacgttct ctgagaggac gctggccttc      960

gtgcgcttct cattggtcag cggctggggc cagctgctgg accgtggcgc cacggccctg     1020

gagctcatgg tcctcaacgt gccccggctg atgacccagg actgcctgca gcagtcacgg     1080

aaggtgggag actccccaaa tatcacggag tacatgttct gtgccggcta ctcggatggc     1140

agcaaggact cctgcgcggg ggacagtgga ggcccacatg ccacccacta ccggggcacg     1200

tggtacctga cgggcatcgt cagctggggc cagggctgcg caaccgtggg ccactttggg     1260

gtgtacacca gggtctccca gtacatcgag tggctgcaaa agctcatgcg ctcagagcca     1320

cgcccaggag tcctcctgcg agccccattt cccggatccg cagagcccaa atcttgtgac     1380

aaaactcaca catgcccacc gtgcccagca cctgaactcc tggggggacc gtcagtcttc     1440

ctcttccccc caaaacccaa ggacaccctc atgatctccc ggacccctga ggtcacatgc     1500

gtggtggtgg acgtgagcca cgaagaccct gaggtcaagt tcaactggta cgtggacggc     1560

gtggaggtgc ataatgccaa gacaaagccg cgggaggagc agtacaacag cacgtaccgt     1620

gtggtcagcg tcctcaccgt cctgcaccag gactggctga atggcaagga gtacaagtgc     1680

aaggtctcca acaaagccct cccagccccc atcgagaaaa ccatctccaa agccaaaggg     1740

cagccccgag aaccacaggt gtacaccctg cccccatccc gggatgagct gaccaagaac     1800

caggtcagcc tgacctgcct ggtcaaaggc ttctatccca gcgacatcgc cgtggagtgg     1860

gagagcaatg ggcagccgga gaacaactac aagaccacgc ctcccgtgct ggactccgac     1920

ggctccttct tcctctacag caagctcacc gtggacaaga gcaggtggca gcaggggaac     1980

gtcttctcat gctccgtgat gcatgaggct ctgcacaacc actacacgca gaagagcctc     2040

tccctgtctc cgggtaaatg ataagcggcc gc                                   2072


<210>  4
<211>  641
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Homo sapiens factor VII active site mutant immunoconjugate amino 
       acid sequence

<400>  4

Ala Asn Ala Phe Leu Glu Glu Leu Arg Pro Gly Ser Leu Glu Arg Glu 
1               5                   10                  15      


Cys Lys Glu Glu Gln Cys Ser Phe Glu Glu Ala Arg Glu Ile Phe Lys 
            20                  25                  30          


Asp Ala Glu Arg Thr Lys Leu Phe Trp Ile Ser Tyr Ser Asp Gly Asp 
        35                  40                  45              


Gln Cys Ala Ser Ser Pro Cys Gln Asn Gly Gly Ser Cys Lys Asp Gln 
    50                  55                  60                  


Leu Gln Ser Tyr Ile Cys Phe Cys Leu Pro Ala Phe Glu Gly Arg Asn 
65                  70                  75                  80  


Cys Glu Thr His Lys Asp Asp Gln Leu Ile Cys Val Asn Glu Asn Gly 
                85                  90                  95      


Gly Cys Glu Gln Tyr Cys Ser Asp His Thr Gly Thr Lys Arg Ser Cys 
            100                 105                 110         


Arg Cys His Glu Gly Tyr Ser Leu Leu Ala Asp Gly Val Ser Cys Thr 
        115                 120                 125             


Pro Thr Val Glu Tyr Pro Cys Gly Lys Ile Pro Ile Leu Glu Lys Arg 
    130                 135                 140                 


Asn Ala Ser Lys Pro Gln Gly Arg Ile Val Gly Gly Lys Val Cys Pro 
145                 150                 155                 160 


Lys Gly Glu Cys Pro Trp Gln Val Leu Leu Leu Val Asn Gly Ala Gln 
                165                 170                 175     


Leu Cys Gly Gly Thr Leu Ile Asn Thr Ile Trp Val Val Ser Ala Ala 
            180                 185                 190         


His Cys Phe Asp Lys Ile Lys Asn Trp Arg Asn Leu Ile Ala Val Leu 
        195                 200                 205             


Gly Glu His Asp Leu Ser Glu His Asp Gly Asp Glu Gln Ser Arg Arg 
    210                 215                 220                 


Val Ala Gln Val Ile Ile Pro Ser Thr Tyr Val Pro Gly Thr Thr Asn 
225                 230                 235                 240 


His Asp Ile Ala Leu Leu Arg Leu His Gln Pro Val Val Leu Thr Asp 
                245                 250                 255     


His Val Val Pro Leu Cys Leu Pro Glu Arg Thr Phe Ser Glu Arg Thr 
            260                 265                 270         


Leu Ala Phe Val Arg Phe Ser Leu Val Ser Gly Trp Gly Gln Leu Leu 
        275                 280                 285             


Asp Arg Gly Ala Thr Ala Leu Glu Leu Met Val Leu Asn Val Pro Arg 
    290                 295                 300                 


Leu Met Thr Gln Asp Cys Leu Gln Gln Ser Arg Lys Val Gly Asp Ser 
305                 310                 315                 320 


Pro Asn Ile Thr Glu Tyr Met Phe Cys Ala Gly Tyr Ser Asp Gly Ser 
                325                 330                 335     


Lys Asp Ser Cys Ala Gly Asp Ser Gly Gly Pro His Ala Thr His Tyr 
            340                 345                 350         


Arg Gly Thr Trp Tyr Leu Thr Gly Ile Val Ser Trp Gly Gln Gly Cys 
        355                 360                 365             


Ala Thr Val Gly His Phe Gly Val Tyr Thr Arg Val Ser Gln Tyr Ile 
    370                 375                 380                 


Glu Trp Leu Gln Lys Leu Met Arg Ser Glu Pro Arg Pro Gly Val Leu 
385                 390                 395                 400 


Leu Arg Ala Pro Phe Pro Gly Ser Ala Glu Pro Lys Ser Cys Asp Lys 
                405                 410                 415     


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
            420                 425                 430         


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
        435                 440                 445             


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
    450                 455                 460                 


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
465                 470                 475                 480 


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
                485                 490                 495     


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
            500                 505                 510         


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
        515                 520                 525             


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
    530                 535                 540                 


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
545                 550                 555                 560 


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
                565                 570                 575     


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
            580                 585                 590         


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
        595                 600                 605             


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
    610                 615                 620                 


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
625                 630                 635                 640 


Lys 
    


<210>  5
<211>  641
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Homo sapiens factor VII active site mutant immunoconjugate amino 
       acid sequence, S344A and A341K (relative to SEQ ID NO:4)

<400>  5

Ala Asn Ala Phe Leu Glu Glu Leu Arg Pro Gly Ser Leu Glu Arg Glu 
1               5                   10                  15      


Cys Lys Glu Glu Gln Cys Ser Phe Glu Glu Ala Arg Glu Ile Phe Lys 
            20                  25                  30          


Asp Ala Glu Arg Thr Lys Leu Phe Trp Ile Ser Tyr Ser Asp Gly Asp 
        35                  40                  45              


Gln Cys Ala Ser Ser Pro Cys Gln Asn Gly Gly Ser Cys Lys Asp Gln 
    50                  55                  60                  


Leu Gln Ser Tyr Ile Cys Phe Cys Leu Pro Ala Phe Glu Gly Arg Asn 
65                  70                  75                  80  


Cys Glu Thr His Lys Asp Asp Gln Leu Ile Cys Val Asn Glu Asn Gly 
                85                  90                  95      


Gly Cys Glu Gln Tyr Cys Ser Asp His Thr Gly Thr Lys Arg Ser Cys 
            100                 105                 110         


Arg Cys His Glu Gly Tyr Ser Leu Leu Ala Asp Gly Val Ser Cys Thr 
        115                 120                 125             


Pro Thr Val Glu Tyr Pro Cys Gly Lys Ile Pro Ile Leu Glu Lys Arg 
    130                 135                 140                 


Asn Ala Ser Lys Pro Gln Gly Arg Ile Val Gly Gly Lys Val Cys Pro 
145                 150                 155                 160 


Lys Gly Glu Cys Pro Trp Gln Val Leu Leu Leu Val Asn Gly Ala Gln 
                165                 170                 175     


Leu Cys Gly Gly Thr Leu Ile Asn Thr Ile Trp Val Val Ser Ala Ala 
            180                 185                 190         


His Cys Phe Asp Lys Ile Lys Asn Trp Arg Asn Leu Ile Ala Val Leu 
        195                 200                 205             


Gly Glu His Asp Leu Ser Glu His Asp Gly Asp Glu Gln Ser Arg Arg 
    210                 215                 220                 


Val Ala Gln Val Ile Ile Pro Ser Thr Tyr Val Pro Gly Thr Thr Asn 
225                 230                 235                 240 


His Asp Ile Ala Leu Leu Arg Leu His Gln Pro Val Val Leu Thr Asp 
                245                 250                 255     


His Val Val Pro Leu Cys Leu Pro Glu Arg Thr Phe Ser Glu Arg Thr 
            260                 265                 270         


Leu Ala Phe Val Arg Phe Ser Leu Val Ser Gly Trp Gly Gln Leu Leu 
        275                 280                 285             


Asp Arg Gly Ala Thr Ala Leu Glu Leu Met Val Leu Asn Val Pro Arg 
    290                 295                 300                 


Leu Met Thr Gln Asp Cys Leu Gln Gln Ser Arg Lys Val Gly Asp Ser 
305                 310                 315                 320 


Pro Asn Ile Thr Glu Tyr Met Phe Cys Ala Gly Tyr Ser Asp Gly Ser 
                325                 330                 335     


Lys Asp Ser Cys Lys Gly Asp Ala Gly Gly Pro His Ala Thr His Tyr 
            340                 345                 350         


Arg Gly Thr Trp Tyr Leu Thr Gly Ile Val Ser Trp Gly Gln Gly Cys 
        355                 360                 365             


Ala Thr Val Gly His Phe Gly Val Tyr Thr Arg Val Ser Gln Tyr Ile 
    370                 375                 380                 


Glu Trp Leu Gln Lys Leu Met Arg Ser Glu Pro Arg Pro Gly Val Leu 
385                 390                 395                 400 


Leu Arg Ala Pro Phe Pro Gly Ser Ala Glu Pro Lys Ser Cys Asp Lys 
                405                 410                 415     


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
            420                 425                 430         


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
        435                 440                 445             


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
    450                 455                 460                 


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
465                 470                 475                 480 


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
                485                 490                 495     


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
            500                 505                 510         


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
        515                 520                 525             


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
    530                 535                 540                 


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
545                 550                 555                 560 


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
                565                 570                 575     


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
            580                 585                 590         


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
        595                 600                 605             


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
    610                 615                 620                 


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
625                 630                 635                 640 


Lys 
    


<210>  6
<211>  2057
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FVII active site mutant coding sequence

<400>  6
ggatccacca tggtgtcaca agccctccgc ctgctctgcc tccttctcgg acttcaagga       60

tgtctggccg cagtgttcgt gactcaagaa gaggcccacg gggtgctgca ccggaggcgc      120

cgcgcgaacg cctttctgga ggagctgcgg ccaggctcgc tggaaagaga gtgcaaagag      180

gagcaatgct ccttcgagga ggccagagaa attttcaagg acgccgaacg gactaagctg      240

ttttggatct catacagcga cggcgaccag tgtgccagca gcccgtgcca gaacggcggt      300

tcgtgcaagg accagctgca gtcctacatt tgtttctgcc tgccggcgtt cgaaggaaga      360

aactgtgaaa cccacaagga tgaccagctg atctgcgtga acgagaacgg aggctgcgaa      420

cagtactgct ccgaccacac ggggactaag aggagctgca gatgccatga gggctatagc      480

ctgctggccg acggggtgtc ctgcactccg actgtggaat acccgtgcgg aaagatcccc      540

atcctggaga agcggaacgc atccaagccc caaggacgaa ttgtcggcgg aaaggtctgc      600

cctaagggag agtgtccttg gcaagtgctc ctcttggtga acggagcgca gctttgcggc      660

ggaactctga tcaacaccat ctgggtggtg tcggcagctc actgctttga taagattaag      720

aactggcgga acctgatcgc ggtgcttggc gaacatgacc tgtccgaaca cgacggggac      780

gagcagtccc ggagagtggc ccaggtcatc attccatcca cctacgtgcc ggggaccaca      840

aaccacgaca tcgccttgct gcggctgcac cagccggtgg tccttaccga tcacgtcgtg      900

ccgctctgcc tgcccgagcg cacctttagc gagcgcaccc tggccttcgt gcgcttctcc      960

ctggtgtccg gctggggaca gctgctggac agaggcgcca ccgccctgga actgatggtg     1020

ctgaacgtgc cacggctcat gacccaagat tgtctgcagc agtcgcgcaa agtcggggat     1080

tcaccgaaca tcaccgagta catgttctgc gccggttact ccgatggatc gaaggactcg     1140

tgcgctggag actccggtgg accccatgct acccattatc gcggtacttg gtacctgact     1200

ggtattgtgt cctggggaca gggctgcgcc accgtgggac atttcggcgt gtacacaagg     1260

gtgtcacagt acatcgaatg gttgcagaag ctcatgcgca gcgaacctcg cccgggagtg     1320

ctcctgaggg cccctttccc cggaagcgct gagcctaaga gctgcgacaa gacccacact     1380

tgtccgccat gccccgcgcc cgaactgctg ggtggcccat ccgtgttcct gttcccgcct     1440

aagcccaagg acaccctgat gatttcgcgg acccccgaag tgacttgcgt ggtggtggac     1500

gtcagccacg aagatccgga agtcaagttc aattggtacg tggatggcgt cgaagtccat     1560

aacgccaaga ccaagccccg cgaggagcag tacaattcca cttaccgggt ggtgtccgtg     1620

ttgaccgtgt tgcaccagga ctggctgaac ggaaaggaat acaagtgcaa agtgtcgaat     1680

aaggccctcc cggccccgat cgagaaaacg atctccaagg ccaagggcca gcctcgggag     1740

ccccaggtct acaccttgcc gccgtcccgg gatgagctga ccaagaacca ggtgtcactc     1800

acctgtctcg tcaaggggtt ctacccttcc gacatcgccg tggaatggga gtcgaacggg     1860

cagccggaaa acaattacaa gaccactcct cctgtcctgg attccgacgg gtcattcttc     1920

ctgtactcaa agctgaccgt ggacaagagc agatggcaac agggcaacgt gttcagctgc     1980

tccgtgatgc acgaggccct gcacaaccac tacacccaga agtccctgtc cctctctccc     2040

ggaaaatgag cggccgc                                                    2057


<210>  7
<211>  2057
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FVII active site mutant coding sequence

<400>  7
tctagaccac catggtgtca caagccctcc gcctgctctg cctccttctc ggacttcaag       60

gatgtctggc cgcagtgttc gtgactcaag aagaggccca cggggtgctg caccggaggc      120

gccgcgcgaa cgcctttctg gaggagctgc ggccaggctc gctggaaaga gagtgcaaag      180

aggagcaatg ctccttcgag gaggccagag aaattttcaa ggacgccgaa cggactaagc      240

tgttttggat ctcatacagc gacggcgacc agtgtgccag cagcccgtgc cagaacggcg      300

gttcgtgcaa ggaccagctg cagtcctaca tttgtttctg cctgccggcg ttcgaaggaa      360

gaaactgtga aacccacaag gatgaccagc tgatctgcgt gaacgagaac ggaggctgcg      420

aacagtactg ctccgaccac acggggacta agaggagctg cagatgccat gagggctata      480

gcctgctggc cgacggggtg tcctgcactc cgactgtgga atacccgtgc ggaaagatcc      540

ccatcctgga gaagcggaac gcatccaagc cccaaggacg aattgtcggc ggaaaggtct      600

gccctaaggg agagtgtcct tggcaagtgc tcctcttggt gaacggagcg cagctttgcg      660

gcggaactct gatcaacacc atctgggtgg tgtcggcagc tcactgcttt gataagatta      720

agaactggcg gaacctgatc gcggtgcttg gcgaacatga cctgtccgaa cacgacgggg      780

acgagcagtc ccggagagtg gcccaggtca tcattccatc cacctacgtg ccggggacca      840

caaaccacga catcgccttg ctgcggctgc accagccggt ggtccttacc gatcacgtcg      900

tgccgctctg cctgcccgag cgcaccttta gcgagcgcac cctggccttc gtgcgcttct      960

ccctggtgtc cggctgggga cagctgctgg acagaggcgc caccgccctg gaactgatgg     1020

tgctgaacgt gccacggctc atgacccaag attgtctgca gcagtcgcgc aaagtcgggg     1080

attcaccgaa catcaccgag tacatgttct gcgccggtta ctccgatgga tcgaaggact     1140

cgtgcgctgg agactccggt ggaccccatg ctacccatta tcgcggtact tggtacctga     1200

ctggtattgt gtcctgggga cagggctgcg ccaccgtggg acatttcggc gtgtacacaa     1260

gggtgtcaca gtacatcgaa tggttgcaga agctcatgcg cagcgaacct cgcccgggag     1320

tgctcctgag ggcccctttc cccggaagcg ctgagcctaa gagctgcgac aagacccaca     1380

cttgtccgcc atgccccgcg cccgaactgc tgggtggccc atccgtgttc ctgttcccgc     1440

ctaagcccaa ggacaccctg atgatttcgc ggacccccga agtgacttgc gtggtggtgg     1500

acgtcagcca cgaagatccg gaagtcaagt tcaattggta cgtggatggc gtcgaagtcc     1560

ataacgccaa gaccaagccc cgcgaggagc agtacaattc cacttaccgg gtggtgtccg     1620

tgttgaccgt gttgcaccag gactggctga acggaaagga atacaagtgc aaagtgtcga     1680

ataaggccct cccggccccg atcgagaaaa cgatctccaa ggccaagggc cagcctcggg     1740

agccccaggt ctacaccttg ccgccgtccc gggatgagct gaccaagaac caggtgtcac     1800

tcacctgtct cgtcaagggg ttctaccctt ccgacatcgc cgtggaatgg gagtcgaacg     1860

ggcagccgga aaacaattac aagaccactc ctcctgtcct ggattccgac gggtcattct     1920

tcctgtactc aaagctgacc gtggacaaga gcagatggca acagggcaac gtgttcagct     1980

gctccgtgat gcacgaggcc ctgcacaacc actacaccca gaagtccctg tccctctctc     2040

ccggaaaatg aaccggt                                                    2057


<210>  8
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Immunoconjugate linker - upper hinge region amino acid sequence

<400>  8

Gly Ser Ala Glu Pro Lys Ser Cys 
1               5               


<210>  9
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Immunoconjugate mutant linker - upper hinge region amino acid 
       sequence; C-terminal cysteine mutated to serine (relative to SEQ 
       ID NO:8)

<400>  9

Gly Ser Ala Glu Pro Lys Ser Ser 
1               5               


<210>  10
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Immunoconjugate mutant linker - upper hinge region amino acid 
       sequence; lysine at position 6 mutated to alanine (relative to 
       SEQ ID NO:9)

<400>  10

Gly Ser Ala Glu Pro Ala Ser Ser 
1               5               


<210>  11
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Immunoconjugate mutant linker - upper hinge region amino acid 
       sequence; serine at position 2 mutated to glycine and residues 
       3-6 deleted (relative to SEQ ID NO:9)

<400>  11

Gly Gly Ser Ser 
1               


<210>  12
<211>  406
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human factor VII active site mutant amino acid sequence

<400>  12

Ala Asn Ala Phe Leu Glu Glu Leu Arg Pro Gly Ser Leu Glu Arg Glu 
1               5                   10                  15      


Cys Lys Glu Glu Gln Cys Ser Phe Glu Glu Ala Arg Glu Ile Phe Lys 
            20                  25                  30          


Asp Ala Glu Arg Thr Lys Leu Phe Trp Ile Ser Tyr Ser Asp Gly Asp 
        35                  40                  45              


Gln Cys Ala Ser Ser Pro Cys Gln Asn Gly Gly Ser Cys Lys Asp Gln 
    50                  55                  60                  


Leu Gln Ser Tyr Ile Cys Phe Cys Leu Pro Ala Phe Glu Gly Arg Asn 
65                  70                  75                  80  


Cys Glu Thr His Lys Asp Asp Gln Leu Ile Cys Val Asn Glu Asn Gly 
                85                  90                  95      


Gly Cys Glu Gln Tyr Cys Ser Asp His Thr Gly Thr Lys Arg Ser Cys 
            100                 105                 110         


Arg Cys His Glu Gly Tyr Ser Leu Leu Ala Asp Gly Val Ser Cys Thr 
        115                 120                 125             


Pro Thr Val Glu Tyr Pro Cys Gly Lys Ile Pro Ile Leu Glu Lys Arg 
    130                 135                 140                 


Asn Ala Ser Lys Pro Gln Gly Arg Ile Val Gly Gly Lys Val Cys Pro 
145                 150                 155                 160 


Lys Gly Glu Cys Pro Trp Gln Val Leu Leu Leu Val Asn Gly Ala Gln 
                165                 170                 175     


Leu Cys Gly Gly Thr Leu Ile Asn Thr Ile Trp Val Val Ser Ala Ala 
            180                 185                 190         


His Cys Phe Asp Lys Ile Lys Asn Trp Arg Asn Leu Ile Ala Val Leu 
        195                 200                 205             


Gly Glu His Asp Leu Ser Glu His Asp Gly Asp Glu Gln Ser Arg Arg 
    210                 215                 220                 


Val Ala Gln Val Ile Ile Pro Ser Thr Tyr Val Pro Gly Thr Thr Asn 
225                 230                 235                 240 


His Asp Ile Ala Leu Leu Arg Leu His Gln Pro Val Val Leu Thr Asp 
                245                 250                 255     


His Val Val Pro Leu Cys Leu Pro Glu Arg Thr Phe Ser Glu Arg Thr 
            260                 265                 270         


Leu Ala Phe Val Arg Phe Ser Leu Val Ser Gly Trp Gly Gln Leu Leu 
        275                 280                 285             


Asp Arg Gly Ala Thr Ala Leu Glu Leu Met Val Leu Asn Val Pro Arg 
    290                 295                 300                 


Leu Met Thr Gln Asp Cys Leu Gln Gln Ser Arg Lys Val Gly Asp Ser 
305                 310                 315                 320 


Pro Asn Ile Thr Glu Tyr Met Phe Cys Ala Gly Tyr Ser Asp Gly Ser 
                325                 330                 335     


Lys Asp Ser Cys Ala Gly Asp Ser Gly Gly Pro His Ala Thr His Tyr 
            340                 345                 350         


Arg Gly Thr Trp Tyr Leu Thr Gly Ile Val Ser Trp Gly Gln Gly Cys 
        355                 360                 365             


Ala Thr Val Gly His Phe Gly Val Tyr Thr Arg Val Ser Gln Tyr Ile 
    370                 375                 380                 


Glu Trp Leu Gln Lys Leu Met Arg Ser Glu Pro Arg Pro Gly Val Leu 
385                 390                 395                 400 


Leu Arg Ala Pro Phe Pro 
                405     


<210>  13
<211>  227
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG Fc amino acid sequence (with lower hinge)

<400>  13

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys 
225         


<210>  14
<211>  227
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG Fc amino acid sequence (with lower hinge) with protA mutation

<400>  14

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn Arg Phe Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys 
225         


<210>  15
<211>  227
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG Fc amino acid sequence with T366Y knob mutation (relative to 
       SEQ ID NO:13)

<400>  15

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Tyr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys 
225         


<210>  16
<211>  227
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG Fc amino acid sequence with T366Y knob mutation (relative to 
       SEQ ID NO:13) and protA mutation

<400>  16

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Tyr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn Arg Phe Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys 
225         


<210>  17
<211>  227
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG Fc amino acid sequence with Y407T hole mutation (relative to 
       SEQ ID NO:13)

<400>  17

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Thr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys 
225         


<210>  18
<211>  227
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG Fc region with Y407T hole mutation (relative to SEQ ID NO:13)
       and protA mutation

<400>  18

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Thr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn Arg Phe Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys 
225         


<210>  19
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Upper hinge region amino acid sequence

<400>  19

Glu Pro Lys Ser Cys 
1               5   


<210>  20
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Lower hinge region amino acid sequence

<400>  20

Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
1               5                   10  


<210>  21
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EPKSCDKTHTCPPCPAPELLGGP

<400>  21

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly Pro 
            20              


<210>  22
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Truncated IgG1 hinge amino acid sequence

<400>  22

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro 
        


<210>  23
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutated IgG1 hinge amino acid sequence - N-terminal cysteine 
       mutated to serine (relative to SEQ ID NO:21)

<400>  23

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly Pro 
            20              


<210>  24
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutated IgG1 hinge amino acid sequence - N-terminal lysine 
       mutated to alanine (relative to SEQ ID NO:23)

<400>  24

Glu Pro Ala Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly Pro 
            20              


<210>  25
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG4 hinge amino acid sequence

<400>  25

Glu Ser Lys Tyr Gly Pro Pro Cys Pro Ser Cys Pro Ala Pro Glu Phe 
1               5                   10                  15      


Leu Gly Gly Pro 
            20  


<210>  26
<211>  232
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 Fc amino acid sequence comprising IgG1 hinge amino acid 
       sequence

<400>  26

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Lys 
225                 230         


<210>  27
<211>  209
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 Fc amino acid sequence without hinge sequence

<400>  27

Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
1               5                   10                  15      


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            20                  25                  30          


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        35                  40                  45              


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    50                  55                  60                  


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
65                  70                  75                  80  


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
                85                  90                  95      


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            100                 105                 110         


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
        115                 120                 125             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    130                 135                 140                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
145                 150                 155                 160 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                165                 170                 175     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            180                 185                 190         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        195                 200                 205             


Lys 
    


<210>  28
<211>  209
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 Fc amino acid sequence with protA mutation and without hinge
       sequence

<400>  28

Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
1               5                   10                  15      


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            20                  25                  30          


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        35                  40                  45              


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    50                  55                  60                  


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
65                  70                  75                  80  


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
                85                  90                  95      


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            100                 105                 110         


Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
        115                 120                 125             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    130                 135                 140                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
145                 150                 155                 160 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                165                 170                 175     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            180                 185                 190         


Ala Leu His Asn Arg Phe Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        195                 200                 205             


Lys 
    


<210>  29
<211>  209
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 Fc amino acid sequence with T366Y knob mutation (relative to
       SEQ ID NO:13) and without hinge sequence

<400>  29

Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
1               5                   10                  15      


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            20                  25                  30          


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        35                  40                  45              


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    50                  55                  60                  


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
65                  70                  75                  80  


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
                85                  90                  95      


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            100                 105                 110         


Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Tyr 
        115                 120                 125             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    130                 135                 140                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
145                 150                 155                 160 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                165                 170                 175     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            180                 185                 190         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        195                 200                 205             


Lys 
    


<210>  30
<211>  209
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 Fc amino acid sequence with T366Y knob mutation (relative to
       SEQ ID NO:13) with protA mutation and without hinge sequence

<400>  30

Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
1               5                   10                  15      


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            20                  25                  30          


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        35                  40                  45              


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    50                  55                  60                  


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
65                  70                  75                  80  


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
                85                  90                  95      


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            100                 105                 110         


Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Tyr 
        115                 120                 125             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    130                 135                 140                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
145                 150                 155                 160 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                165                 170                 175     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            180                 185                 190         


Ala Leu His Asn Arg Phe Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        195                 200                 205             


Lys 
    


<210>  31
<211>  209
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 Fc amino acid sequence with Y407T hole mutation (relative to
       SEQ ID NO:13) and without hinge sequence

<400>  31

Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
1               5                   10                  15      


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            20                  25                  30          


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        35                  40                  45              


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    50                  55                  60                  


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
65                  70                  75                  80  


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
                85                  90                  95      


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            100                 105                 110         


Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
        115                 120                 125             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    130                 135                 140                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
145                 150                 155                 160 


Asp Ser Asp Gly Ser Phe Phe Leu Thr Ser Lys Leu Thr Val Asp Lys 
                165                 170                 175     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            180                 185                 190         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        195                 200                 205             


Lys 
    


<210>  32
<211>  209
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 Fc amino acid sequence with Y407T hole mutation (relative to
       SEQ ID NO:13) with protA mutation and without hinge sequence

<400>  32

Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
1               5                   10                  15      


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            20                  25                  30          


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        35                  40                  45              


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    50                  55                  60                  


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
65                  70                  75                  80  


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
                85                  90                  95      


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            100                 105                 110         


Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
        115                 120                 125             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    130                 135                 140                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
145                 150                 155                 160 


Asp Ser Asp Gly Ser Phe Phe Leu Thr Ser Lys Leu Thr Val Asp Lys 
                165                 170                 175     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            180                 185                 190         


Ala Leu His Asn Arg Phe Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        195                 200                 205             


Lys 
    


<210>  33
<211>  406
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human factor VII active site mutant amino acid sequence

<400>  33

Ala Asn Ala Phe Leu Glu Glu Leu Arg Pro Gly Ser Leu Glu Arg Glu 
1               5                   10                  15      


Cys Lys Glu Glu Gln Cys Ser Phe Glu Glu Ala Arg Glu Ile Phe Lys 
            20                  25                  30          


Asp Ala Glu Arg Thr Lys Leu Phe Trp Ile Ser Tyr Ser Asp Gly Asp 
        35                  40                  45              


Gln Cys Ala Ser Ser Pro Cys Gln Asn Gly Gly Ser Cys Lys Asp Gln 
    50                  55                  60                  


Leu Gln Ser Tyr Ile Cys Phe Cys Leu Pro Ala Phe Glu Gly Arg Asn 
65                  70                  75                  80  


Cys Glu Thr His Lys Asp Asp Gln Leu Ile Cys Val Asn Glu Asn Gly 
                85                  90                  95      


Gly Cys Glu Gln Tyr Cys Ser Asp His Thr Gly Thr Lys Arg Ser Cys 
            100                 105                 110         


Arg Cys His Glu Gly Tyr Ser Leu Leu Ala Asp Gly Val Ser Cys Thr 
        115                 120                 125             


Pro Thr Val Glu Tyr Pro Cys Gly Lys Ile Pro Ile Leu Glu Lys Arg 
    130                 135                 140                 


Asn Ala Ser Lys Pro Gln Gly Arg Ile Val Gly Gly Lys Val Cys Pro 
145                 150                 155                 160 


Lys Gly Glu Cys Pro Trp Gln Val Leu Leu Leu Val Asn Gly Ala Gln 
                165                 170                 175     


Leu Cys Gly Gly Thr Leu Ile Asn Thr Ile Trp Val Val Ser Ala Ala 
            180                 185                 190         


His Cys Phe Asp Lys Ile Lys Asn Trp Arg Asn Leu Ile Ala Val Leu 
        195                 200                 205             


Gly Glu His Asp Leu Ser Glu His Asp Gly Asp Glu Gln Ser Arg Arg 
    210                 215                 220                 


Val Ala Gln Val Ile Ile Pro Ser Thr Tyr Val Pro Gly Thr Thr Asn 
225                 230                 235                 240 


His Asp Ile Ala Leu Leu Arg Leu His Gln Pro Val Val Leu Thr Asp 
                245                 250                 255     


His Val Val Pro Leu Cys Leu Pro Glu Arg Thr Phe Ser Glu Arg Thr 
            260                 265                 270         


Leu Ala Phe Val Arg Phe Ser Leu Val Ser Gly Trp Gly Gln Leu Leu 
        275                 280                 285             


Asp Arg Gly Ala Thr Ala Leu Glu Leu Met Val Leu Asn Val Pro Arg 
    290                 295                 300                 


Leu Met Thr Gln Asp Cys Leu Gln Gln Ser Arg Lys Val Gly Asp Ser 
305                 310                 315                 320 


Pro Asn Ile Thr Glu Tyr Met Phe Cys Ala Gly Tyr Ser Asp Gly Ser 
                325                 330                 335     


Lys Asp Ser Cys Ala Gly Asp Ser Gly Gly Pro His Ala Thr His Tyr 
            340                 345                 350         


Arg Gly Thr Trp Tyr Leu Thr Gly Ile Val Ser Trp Gly Gln Gly Cys 
        355                 360                 365             


Ala Thr Val Gly His Phe Gly Val Tyr Thr Arg Val Ser Gln Tyr Ile 
    370                 375                 380                 


Glu Trp Leu Gln Lys Leu Met Arg Ser Glu Pro Arg Pro Gly Val Leu 
385                 390                 395                 400 


Leu Arg Ala Pro Phe Pro 
                405     


<210>  34
<211>  406
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human factor VII active site mutant amino acid sequence with 
       mutations S344A and A341K relative to SEQ ID NO:33

<400>  34

Ala Asn Ala Phe Leu Glu Glu Leu Arg Pro Gly Ser Leu Glu Arg Glu 
1               5                   10                  15      


Cys Lys Glu Glu Gln Cys Ser Phe Glu Glu Ala Arg Glu Ile Phe Lys 
            20                  25                  30          


Asp Ala Glu Arg Thr Lys Leu Phe Trp Ile Ser Tyr Ser Asp Gly Asp 
        35                  40                  45              


Gln Cys Ala Ser Ser Pro Cys Gln Asn Gly Gly Ser Cys Lys Asp Gln 
    50                  55                  60                  


Leu Gln Ser Tyr Ile Cys Phe Cys Leu Pro Ala Phe Glu Gly Arg Asn 
65                  70                  75                  80  


Cys Glu Thr His Lys Asp Asp Gln Leu Ile Cys Val Asn Glu Asn Gly 
                85                  90                  95      


Gly Cys Glu Gln Tyr Cys Ser Asp His Thr Gly Thr Lys Arg Ser Cys 
            100                 105                 110         


Arg Cys His Glu Gly Tyr Ser Leu Leu Ala Asp Gly Val Ser Cys Thr 
        115                 120                 125             


Pro Thr Val Glu Tyr Pro Cys Gly Lys Ile Pro Ile Leu Glu Lys Arg 
    130                 135                 140                 


Asn Ala Ser Lys Pro Gln Gly Arg Ile Val Gly Gly Lys Val Cys Pro 
145                 150                 155                 160 


Lys Gly Glu Cys Pro Trp Gln Val Leu Leu Leu Val Asn Gly Ala Gln 
                165                 170                 175     


Leu Cys Gly Gly Thr Leu Ile Asn Thr Ile Trp Val Val Ser Ala Ala 
            180                 185                 190         


His Cys Phe Asp Lys Ile Lys Asn Trp Arg Asn Leu Ile Ala Val Leu 
        195                 200                 205             


Gly Glu His Asp Leu Ser Glu His Asp Gly Asp Glu Gln Ser Arg Arg 
    210                 215                 220                 


Val Ala Gln Val Ile Ile Pro Ser Thr Tyr Val Pro Gly Thr Thr Asn 
225                 230                 235                 240 


His Asp Ile Ala Leu Leu Arg Leu His Gln Pro Val Val Leu Thr Asp 
                245                 250                 255     


His Val Val Pro Leu Cys Leu Pro Glu Arg Thr Phe Ser Glu Arg Thr 
            260                 265                 270         


Leu Ala Phe Val Arg Phe Ser Leu Val Ser Gly Trp Gly Gln Leu Leu 
        275                 280                 285             


Asp Arg Gly Ala Thr Ala Leu Glu Leu Met Val Leu Asn Val Pro Arg 
    290                 295                 300                 


Leu Met Thr Gln Asp Cys Leu Gln Gln Ser Arg Lys Val Gly Asp Ser 
305                 310                 315                 320 


Pro Asn Ile Thr Glu Tyr Met Phe Cys Ala Gly Tyr Ser Asp Gly Ser 
                325                 330                 335     


Lys Asp Ser Cys Lys Gly Asp Ala Gly Gly Pro His Ala Thr His Tyr 
            340                 345                 350         


Arg Gly Thr Trp Tyr Leu Thr Gly Ile Val Ser Trp Gly Gln Gly Cys 
        355                 360                 365             


Ala Thr Val Gly His Phe Gly Val Tyr Thr Arg Val Ser Gln Tyr Ile 
    370                 375                 380                 


Glu Trp Leu Gln Lys Leu Met Arg Ser Glu Pro Arg Pro Gly Val Leu 
385                 390                 395                 400 


Leu Arg Ala Pro Phe Pro 
                405     


<210>  35
<211>  7304
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleic acid sequence of pbudcd4.1 ICON Fc/knob and Fc/hole 
       (construct JT075)

<400>  35
gcgcgcgttg acattgatta ttgactagtt attaatagta atcaattacg gggtcattag       60

ttcatagccc atatatggag ttccgcgtta cataacttac ggtaaatggc ccgcctggct      120

gaccgcccaa cgacccccgc ccattgacgt caataatgac gtatgttccc atagtaacgc      180

caatagggac tttccattga cgtcaatggg tggactattt acggtaaact gcccacttgg      240

cagtacatca agtgtatcat atgccaagta cgccccctat tgacgtcaat gacggtaaat      300

ggcccgcctg gcattatgcc cagtacatga ccttatggga ctttcctact tggcagtaca      360

tctacgtatt agtcatcgct attaccatgg tgatgcggtt ttggcagtac atcaatgggc      420

gtggatagcg gtttgactca cggggatttc caagtctcca ccccattgac gtcaatggga      480

gtttgttttg gcaccaaaat caacgggact ttccaaaatg tcgtaacaac tccgccccat      540

tgacgcaaat gggcggtagg cgtgtacggt gggaggtcta tataagcaga gctctctggc      600

taactagaga acccactgct tactggctta tcgaaattaa tacgactcac tatagggaga      660

cccaagctta ccatggagtg gtcctgggtg tttctgttct tcctgagcgt gaccaccgga      720

gtgcacagcg acaagaccca cacctgtccc ccttgtcctg cccccgaact gctgggaggc      780

ccttccgtgt tcctgtttcc tcccaagccc aaggacaccc tgatgatcag caggaccccc      840

gaggtgacct gtgtggtcgt ggacgtgtcc cacgaggacc ctgaggtgaa gttcaactgg      900

tacgtggacg gcgtggaggt gcacaacgcc aagacaaagc cccgtgagga gcagtacaac      960

agcacctaca gggtggtgtc cgtgctgaca gtgctgcacc aggactggct gaatggcaag     1020

gagtacaagt gcaaagtgag caacaaggcc ctgcccgccc ccattgagaa gaccatcagc     1080

aaggccaagg gccagcccag agagcctcag gtgtacacac tgcccccctc cagggaggag     1140

atgaccaaga accaggtgag cctgacctgt ctggtgaagg gcttctaccc tagcgacatc     1200

gccgtggagt gggaaagcaa cggccagccc gagaacaact acaagacaac cccccctgtg     1260

ctggacagcg atggctcctt cttcctgaca agcaagctga cagtggacaa gagcaggtgg     1320

cagcagggca acgtcttctc ctgcagcgtg atgcacgaag ccctgcacaa ccactacacc     1380

cagaagagcc tgagcctgag ccccggctga tgatctagag gatccgaaca aaaactcatc     1440

tcagaagagg atctgaatat gcataccggt catcatcacc atcaccattg agtttgatcc     1500

ccgggaattc agacatgata agatacattg atgagtttgg acaaaccaca actagaatgc     1560

agtgaaaaaa atgctttatt tgtgaaattt gtgatgctat tgctttattt gtaaccatta     1620

taagctgcaa taaacaagtt ggggtgggcg aagaactcca gcatgagatc cccgcgctgg     1680

aggatcatcc agccggcgtc ccggaaaacg attccgaagc ccaacctttc atagaaggcg     1740

gcggtggaat cgaaatctcg tagcacgtgt cagtcctgct cctcggccac gaagtgcacg     1800

cagttgccgg ccgggtcgcg cagggcgaac tcccgccccc acggctgctc gccgatctcg     1860

gtcatggccg gcccggaggc gtcccggaag ttcgtggaca cgacctccga ccactcggcg     1920

tacagctcgt ccaggccgcg cacccacacc caggccaggg tgttgtccgg caccacctgg     1980

tcctggaccg cgctgatgaa cagggtcacg tcgtcccgga ccacaccggc gaagtcgtcc     2040

tccacgaagt cccgggagaa cccgagccgg tcggtccaga actcgaccgc tccggcgacg     2100

tcgcgcgcgg tgagcaccgg aacggcactg gtcaacttgg ccatggttta gttcctcacc     2160

ttgtcgtatt atactatgcc gatatactat gccgatgatt aattgtcaac acgtgctgat     2220

cagatccgaa aatggatata caagctcccg ggagcttttt gcaaaagcct aggcctccaa     2280

aaaagcctcc tcactacttc tggaatagct cagaggcaga ggcggcctcg gcctctgcat     2340

aaataaaaaa aattagtcag ccatggggcg gagaatgggc ggaactgggc ggagttaggg     2400

gcgggatggg cggagttagg ggcgggacta tggttgctga ctaattgaga tgcatgcttt     2460

gcatacttct gcctgctggg gagcctgggg actttccaca cctggttgct gactaattga     2520

gatgcatgct ttgcatactt ctgcctgctg gggagcctgg ggactttcca caccctcgtc     2580

gagctagctt cgtgaggctc cggtgcccgt cagtgggcag agcgcacatc gcccacagtc     2640

cccgagaagt tggggggagg ggtcggcaat tgaaccggtg cctagagaag gtggcgcggg     2700

gtaaactggg aaagtgatgt cgtgtactgg ctccgccttt ttcccgaggg tgggggagaa     2760

ccgtatataa gtgcagtagt cgccgtgaac gttctttttc gcaacgggtt tgccgccaga     2820

acacaggtaa gtgccgtgtg tggttcccgc gggcctggcc tctttacggg ttatggccct     2880

tgcgtgcctt gaattacttc cacctggctc cagtacgtga ttcttgatcc cgagctggag     2940

ccaggggcgg gccttgcgct ttaggagccc cttcgcctcg tgcttgagtt gaggcctggc     3000

ctgggcgctg gggccgccgc gtgcgaatct ggtggcacct tcgcgcctgt ctcgctgctt     3060

tcgataagtc tctagccatt taaaattttt gatgacctgc tgcgacgctt tttttctggc     3120

aagatagtct tgtaaatgcg ggccaggatc tgcacactgg tatttcggtt tttgggcccg     3180

cggccggcga cggggcccgt gcgtcccagc gcacatgttc ggcgaggcgg ggcctgcgag     3240

cgcggccacc gagaatcgga cgggggtagt ctcaagctgg ccggcctgct ctggtgcctg     3300

gcctcgcgcc gccgtgtatc gccccgccct gggcggcaag gctggcccgg tcggcaccag     3360

ttgcgtgagc ggaaagatgg ccgcttcccg gccctgctcc agggggctca aaatggagga     3420

cgcggcgctc gggagagcgg gcgggtgagt cacccacaca aaggaaaagg gcctttccgt     3480

cctcagccgt cgcttcatgt gactccacgg agtaccgggc gccgtccagg cacctcgatt     3540

agttctggag cttttggagt acgtcgtctt taggttgggg ggaggggttt tatgcgatgg     3600

agtttcccca cactgagtgg gtggagactg aagttaggcc agcttggcac ttgatgtaat     3660

tctcgttgga atttgccctt tttgagtttg gatcttggtt cattctcaag cctcagacag     3720

tggttcaaag tttttttctt ccatttcagg tgtcgtgaac acgtggtcgc ggccgcttcg     3780

aaggtaccac catggtcagc caggccctca ggctgctctg tctcctgctg ggcctccagg     3840

gctgtctggc tgccgtcttc gtgacccagg aggaggctca cggcgtgctc cacaggagga     3900

gaagagctaa cgctttcctc gaagagctga ggcccggcag cctggaaagg gagtgcaaag     3960

aggagcagtg cagcttcgaa gaagccaggg aaattttcaa ggacgccgag aggaccaagc     4020

tgttctggat ctcctatagc gacggcgatc agtgcgcttc cagcccctgc cagaacggag     4080

gctcctgcaa ggatcagctg cagtcctaca tttgcttctg tctgcccgcc tttgagggca     4140

gaaactgtga gacccacaag gatgaccagc tgatttgtgt gaatgagaac ggcggatgcg     4200

aacagtactg ctccgaccat accggaacaa agaggtcctg cagatgccat gagggctaca     4260

gcctgctggc cgatggagtg agctgcaccc ccaccgtgga atacccctgc ggcaaaatcc     4320

ccatcctgga gaagaggaat gccagcaaac cccagggcag gattgtgggc ggaaaggtgt     4380

gccccaaagg agagtgtcct tggcaggtgc tgctgctcgt gaacggagcc cagctgtgcg     4440

gcggcacact catcaatacc atctgggtgg tcagcgccgc ccactgcttt gacaagatca     4500

agaactggag gaacctcatc gccgtgctgg gagagcacga tctgagcgag catgacggcg     4560

acgaacagtc caggagagtg gcccaggtga tcatccctag cacatatgtc cccggcacca     4620

ccaaccatga tatcgccctc ctcaggctgc atcagcccgt ggtgctgaca gaccacgtgg     4680

tgcctctctg cctgcccgag aggaccttca gcgagaggac cctggccttc gtgagattca     4740

gcctggtgag cggatggggc cagctcctgg atagaggcgc cacagccctg gagctgatgg     4800

tgctgaacgt gcctagactg atgacccaag attgcctcca gcagagcagg aaggtgggag     4860

actcccccaa tatcacagag tatatgtttt gcgccggcta cagcgatggt tctaaagatt     4920

cctgtgctgg cgacagcgga ggcccccacg ctacccacta cagaggcaca tggtatttaa     4980

ccggaatcgt gtcctgggga caaggctgcg ccaccgtggg ccatttcggc gtgtacacca     5040

gggtcagcca gtacatcgaa tggctgcaga aactcatgag gtccgagcct agacccggcg     5100

tcctgctgag agcccctttc cctgataaaa cacacacctg tcccccttgt cctgctcctg     5160

agctcctggg cggaccttcc gtgttcctgt ttcctcccaa acccaaggac accctgatga     5220

tctccaggac ccccgaggtg acatgcgtcg tggtggacgt gagccacgag gaccccgagg     5280

tcaagttcaa ctggtacgtc gatggcgtgg aggtccacaa tgccaagacc aagcccaggg     5340

aggagcaata taactccacc tacagggtgg tcagcgtgct cacagtgctg caccaggatt     5400

ggctgaacgg caaagagtac aagtgcaagg tcagcaacaa agccctgcct gcccccatcg     5460

agaaaaccat ctccaaggct aagggccagc ccagggagcc tcaggtgtac acactgcctc     5520

ctagcagaga ggagatgacc aagaaccagg tcagcctcta ctgcctggtc aaaggcttct     5580

acccctccga tattgctgtg gaatgggagt ccaacggcca acccgagaac aactacaaga     5640

ccacaccccc tgtgctggac agcgacggtt cttttttcct gtacagcaag ctgaccgtcg     5700

ataagagcag atggcagcag ggaaacgtgt tcagctgttc cgtcatgcac gaggccctgc     5760

acaaccacta tacccagaaa agcctctccc tgagccctgg ctgatgaaga tctggccggc     5820

tgggcccgtt tcgaaggtaa gcctatccct aaccctctcc tcggtctcga ttctacgcgt     5880

accggtcatc atcaccatca ccattgagtt taaacccgct gatcagcctc gactgtgcct     5940

tctagttgcc agccatctgt tgtttgcccc tcccccgtgc cttccttgac cctggaaggt     6000

gccactccca ctgtcctttc ctaataaaat gaggaaattg catcgcattg tctgagtagg     6060

tgtcattcta ttctgggggg tggggtgggg caggacagca agggggagga ttgggaagac     6120

aatagcaggc atgctgggga tgcggtgggc tctatggctt ctgaggcgga aagaaccagt     6180

ggcggtaata cggttatcca cagaatcagg ggataacgca ggaaagaaca tgtgagcaaa     6240

aggccagcaa aaggccagga accgtaaaaa ggccgcgttg ctggcgtttt tccataggct     6300

ccgcccccct gacgagcatc acaaaaatcg acgctcaagt cagaggtggc gaaacccgac     6360

aggactataa agataccagg cgtttccccc tggaagctcc ctcgtgcgct ctcctgttcc     6420

gaccctgccg cttaccggat acctgtccgc ctttctccct tcgggaagcg tggcgctttc     6480

tcatagctca cgctgtaggt atctcagttc ggtgtaggtc gttcgctcca agctgggctg     6540

tgtgcacgaa ccccccgttc agcccgaccg ctgcgcctta tccggtaact atcgtcttga     6600

gtccaacccg gtaagacacg acttatcgcc actggcagca gccactggta acaggattag     6660

cagagcgagg tatgtaggcg gtgctacaga gttcttgaag tggtggccta actacggcta     6720

cactagaagg acagtatttg gtatctgcgc tctgctgaag ccagttacct tcggaaaaag     6780

agttggtagc tcttgatccg gcaaacaaac caccgctggt agcggtggtt tttttgtttg     6840

caagcagcag attacgcgca gaaaaaaagg atctcaagaa gatcctttga tcttttctac     6900

ggggtctgac gctcagtgga acgaaaactc acgttaaggg attttggtca tgacattaac     6960

ctataaaaat aggcgtatca cgaggccctt tcgtctcgcg cgtttcggtg atgacggtga     7020

aaacctctga cacatgcagc tcccggagac ggtcacagct tgtctgtaag cggatgccgg     7080

gagcagacaa gcccgtcagg gcgcgtcagc gggtgttggc gggtgtcggg gctggcttaa     7140

ctatgcggca tcagagcaga ttgtactgag agtgcaccat atatgcggtg tgaaataccg     7200

cacagatgcg taaggagaaa ataccgcatc aggcgccatt cgccattcag gctgcgcaac     7260

tgttgggaag ggcgatcggt gcgggcctct tcgctattac gcca                      7304


<210>  36
<211>  3782
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  5' Vector of the construct of SEQ ID NO:35

<400>  36
gcgcgcgttg acattgatta ttgactagtt attaatagta atcaattacg gggtcattag       60

ttcatagccc atatatggag ttccgcgtta cataacttac ggtaaatggc ccgcctggct      120

gaccgcccaa cgacccccgc ccattgacgt caataatgac gtatgttccc atagtaacgc      180

caatagggac tttccattga cgtcaatggg tggactattt acggtaaact gcccacttgg      240

cagtacatca agtgtatcat atgccaagta cgccccctat tgacgtcaat gacggtaaat      300

ggcccgcctg gcattatgcc cagtacatga ccttatggga ctttcctact tggcagtaca      360

tctacgtatt agtcatcgct attaccatgg tgatgcggtt ttggcagtac atcaatgggc      420

gtggatagcg gtttgactca cggggatttc caagtctcca ccccattgac gtcaatggga      480

gtttgttttg gcaccaaaat caacgggact ttccaaaatg tcgtaacaac tccgccccat      540

tgacgcaaat gggcggtagg cgtgtacggt gggaggtcta tataagcaga gctctctggc      600

taactagaga acccactgct tactggctta tcgaaattaa tacgactcac tatagggaga      660

cccaagctta ccatggagtg gtcctgggtg tttctgttct tcctgagcgt gaccaccgga      720

gtgcacagcg acaagaccca cacctgtccc ccttgtcctg cccccgaact gctgggaggc      780

ccttccgtgt tcctgtttcc tcccaagccc aaggacaccc tgatgatcag caggaccccc      840

gaggtgacct gtgtggtcgt ggacgtgtcc cacgaggacc ctgaggtgaa gttcaactgg      900

tacgtggacg gcgtggaggt gcacaacgcc aagacaaagc cccgtgagga gcagtacaac      960

agcacctaca gggtggtgtc cgtgctgaca gtgctgcacc aggactggct gaatggcaag     1020

gagtacaagt gcaaagtgag caacaaggcc ctgcccgccc ccattgagaa gaccatcagc     1080

aaggccaagg gccagcccag agagcctcag gtgtacacac tgcccccctc cagggaggag     1140

atgaccaaga accaggtgag cctgacctgt ctggtgaagg gcttctaccc tagcgacatc     1200

gccgtggagt gggaaagcaa cggccagccc gagaacaact acaagacaac cccccctgtg     1260

ctggacagcg atggctcctt cttcctgaca agcaagctga cagtggacaa gagcaggtgg     1320

cagcagggca acgtcttctc ctgcagcgtg atgcacgaag ccctgcacaa ccactacacc     1380

cagaagagcc tgagcctgag ccccggctga tgatctagag gatccgaaca aaaactcatc     1440

tcagaagagg atctgaatat gcataccggt catcatcacc atcaccattg agtttgatcc     1500

ccgggaattc agacatgata agatacattg atgagtttgg acaaaccaca actagaatgc     1560

agtgaaaaaa atgctttatt tgtgaaattt gtgatgctat tgctttattt gtaaccatta     1620

taagctgcaa taaacaagtt ggggtgggcg aagaactcca gcatgagatc cccgcgctgg     1680

aggatcatcc agccggcgtc ccggaaaacg attccgaagc ccaacctttc atagaaggcg     1740

gcggtggaat cgaaatctcg tagcacgtgt cagtcctgct cctcggccac gaagtgcacg     1800

cagttgccgg ccgggtcgcg cagggcgaac tcccgccccc acggctgctc gccgatctcg     1860

gtcatggccg gcccggaggc gtcccggaag ttcgtggaca cgacctccga ccactcggcg     1920

tacagctcgt ccaggccgcg cacccacacc caggccaggg tgttgtccgg caccacctgg     1980

tcctggaccg cgctgatgaa cagggtcacg tcgtcccgga ccacaccggc gaagtcgtcc     2040

tccacgaagt cccgggagaa cccgagccgg tcggtccaga actcgaccgc tccggcgacg     2100

tcgcgcgcgg tgagcaccgg aacggcactg gtcaacttgg ccatggttta gttcctcacc     2160

ttgtcgtatt atactatgcc gatatactat gccgatgatt aattgtcaac acgtgctgat     2220

cagatccgaa aatggatata caagctcccg ggagcttttt gcaaaagcct aggcctccaa     2280

aaaagcctcc tcactacttc tggaatagct cagaggcaga ggcggcctcg gcctctgcat     2340

aaataaaaaa aattagtcag ccatggggcg gagaatgggc ggaactgggc ggagttaggg     2400

gcgggatggg cggagttagg ggcgggacta tggttgctga ctaattgaga tgcatgcttt     2460

gcatacttct gcctgctggg gagcctgggg actttccaca cctggttgct gactaattga     2520

gatgcatgct ttgcatactt ctgcctgctg gggagcctgg ggactttcca caccctcgtc     2580

gagctagctt cgtgaggctc cggtgcccgt cagtgggcag agcgcacatc gcccacagtc     2640

cccgagaagt tggggggagg ggtcggcaat tgaaccggtg cctagagaag gtggcgcggg     2700

gtaaactggg aaagtgatgt cgtgtactgg ctccgccttt ttcccgaggg tgggggagaa     2760

ccgtatataa gtgcagtagt cgccgtgaac gttctttttc gcaacgggtt tgccgccaga     2820

acacaggtaa gtgccgtgtg tggttcccgc gggcctggcc tctttacggg ttatggccct     2880

tgcgtgcctt gaattacttc cacctggctc cagtacgtga ttcttgatcc cgagctggag     2940

ccaggggcgg gccttgcgct ttaggagccc cttcgcctcg tgcttgagtt gaggcctggc     3000

ctgggcgctg gggccgccgc gtgcgaatct ggtggcacct tcgcgcctgt ctcgctgctt     3060

tcgataagtc tctagccatt taaaattttt gatgacctgc tgcgacgctt tttttctggc     3120

aagatagtct tgtaaatgcg ggccaggatc tgcacactgg tatttcggtt tttgggcccg     3180

cggccggcga cggggcccgt gcgtcccagc gcacatgttc ggcgaggcgg ggcctgcgag     3240

cgcggccacc gagaatcgga cgggggtagt ctcaagctgg ccggcctgct ctggtgcctg     3300

gcctcgcgcc gccgtgtatc gccccgccct gggcggcaag gctggcccgg tcggcaccag     3360

ttgcgtgagc ggaaagatgg ccgcttcccg gccctgctcc agggggctca aaatggagga     3420

cgcggcgctc gggagagcgg gcgggtgagt cacccacaca aaggaaaagg gcctttccgt     3480

cctcagccgt cgcttcatgt gactccacgg agtaccgggc gccgtccagg cacctcgatt     3540

agttctggag cttttggagt acgtcgtctt taggttgggg ggaggggttt tatgcgatgg     3600

agtttcccca cactgagtgg gtggagactg aagttaggcc agcttggcac ttgatgtaat     3660

tctcgttgga atttgccctt tttgagtttg gatcttggtt cattctcaag cctcagacag     3720

tggttcaaag tttttttctt ccatttcagg tgtcgtgaac acgtggtcgc ggccgcttcg     3780

aa                                                                    3782


<210>  37
<211>  1491
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3' Vector of the construct of SEQ ID NO:35

<400>  37
ggccggctgg gcccgtttcg aaggtaagcc tatccctaac cctctcctcg gtctcgattc       60

tacgcgtacc ggtcatcatc accatcacca ttgagtttaa acccgctgat cagcctcgac      120

tgtgccttct agttgccagc catctgttgt ttgcccctcc cccgtgcctt ccttgaccct      180

ggaaggtgcc actcccactg tcctttccta ataaaatgag gaaattgcat cgcattgtct      240

gagtaggtgt cattctattc tggggggtgg ggtggggcag gacagcaagg gggaggattg      300

ggaagacaat agcaggcatg ctggggatgc ggtgggctct atggcttctg aggcggaaag      360

aaccagtggc ggtaatacgg ttatccacag aatcagggga taacgcagga aagaacatgt      420

gagcaaaagg ccagcaaaag gccaggaacc gtaaaaaggc cgcgttgctg gcgtttttcc      480

ataggctccg cccccctgac gagcatcaca aaaatcgacg ctcaagtcag aggtggcgaa      540

acccgacagg actataaaga taccaggcgt ttccccctgg aagctccctc gtgcgctctc      600

ctgttccgac cctgccgctt accggatacc tgtccgcctt tctcccttcg ggaagcgtgg      660

cgctttctca tagctcacgc tgtaggtatc tcagttcggt gtaggtcgtt cgctccaagc      720

tgggctgtgt gcacgaaccc cccgttcagc ccgaccgctg cgccttatcc ggtaactatc      780

gtcttgagtc caacccggta agacacgact tatcgccact ggcagcagcc actggtaaca      840

ggattagcag agcgaggtat gtaggcggtg ctacagagtt cttgaagtgg tggcctaact      900

acggctacac tagaaggaca gtatttggta tctgcgctct gctgaagcca gttaccttcg      960

gaaaaagagt tggtagctct tgatccggca aacaaaccac cgctggtagc ggtggttttt     1020

ttgtttgcaa gcagcagatt acgcgcagaa aaaaaggatc tcaagaagat cctttgatct     1080

tttctacggg gtctgacgct cagtggaacg aaaactcacg ttaagggatt ttggtcatga     1140

cattaaccta taaaaatagg cgtatcacga ggccctttcg tctcgcgcgt ttcggtgatg     1200

acggtgaaaa cctctgacac atgcagctcc cggagacggt cacagcttgt ctgtaagcgg     1260

atgccgggag cagacaagcc cgtcagggcg cgtcagcggg tgttggcggg tgtcggggct     1320

ggcttaacta tgcggcatca gagcagattg tactgagagt gcaccatata tgcggtgtga     1380

aataccgcac agatgcgtaa ggagaaaata ccgcatcagg cgccattcgc cattcaggct     1440

gcgcaactgt tgggaagggc gatcggtgcg ggcctcttcg ctattacgcc a              1491


<210>  38
<211>  2031
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Insert of the construct of SEQ ID NO:35

<400>  38
ggtaccacca tggtcagcca ggccctcagg ctgctctgtc tcctgctggg cctccagggc       60

tgtctggctg ccgtcttcgt gacccaggag gaggctcacg gcgtgctcca caggaggaga      120

agagctaacg ctttcctcga agagctgagg cccggcagcc tggaaaggga gtgcaaagag      180

gagcagtgca gcttcgaaga agccagggaa attttcaagg acgccgagag gaccaagctg      240

ttctggatct cctatagcga cggcgatcag tgcgcttcca gcccctgcca gaacggaggc      300

tcctgcaagg atcagctgca gtcctacatt tgcttctgtc tgcccgcctt tgagggcaga      360

aactgtgaga cccacaagga tgaccagctg atttgtgtga atgagaacgg cggatgcgaa      420

cagtactgct ccgaccatac cggaacaaag aggtcctgca gatgccatga gggctacagc      480

ctgctggccg atggagtgag ctgcaccccc accgtggaat acccctgcgg caaaatcccc      540

atcctggaga agaggaatgc cagcaaaccc cagggcagga ttgtgggcgg aaaggtgtgc      600

cccaaaggag agtgtccttg gcaggtgctg ctgctcgtga acggagccca gctgtgcggc      660

ggcacactca tcaataccat ctgggtggtc agcgccgccc actgctttga caagatcaag      720

aactggagga acctcatcgc cgtgctggga gagcacgatc tgagcgagca tgacggcgac      780

gaacagtcca ggagagtggc ccaggtgatc atccctagca catatgtccc cggcaccacc      840

aaccatgata tcgccctcct caggctgcat cagcccgtgg tgctgacaga ccacgtggtg      900

cctctctgcc tgcccgagag gaccttcagc gagaggaccc tggccttcgt gagattcagc      960

ctggtgagcg gatggggcca gctcctggat agaggcgcca cagccctgga gctgatggtg     1020

ctgaacgtgc ctagactgat gacccaagat tgcctccagc agagcaggaa ggtgggagac     1080

tcccccaata tcacagagta tatgttttgc gccggctaca gcgatggttc taaagattcc     1140

tgtgctggcg acagcggagg cccccacgct acccactaca gaggcacatg gtatttaacc     1200

ggaatcgtgt cctggggaca aggctgcgcc accgtgggcc atttcggcgt gtacaccagg     1260

gtcagccagt acatcgaatg gctgcagaaa ctcatgaggt ccgagcctag acccggcgtc     1320

ctgctgagag cccctttccc tgataaaaca cacacctgtc ccccttgtcc tgctcctgag     1380

ctcctgggcg gaccttccgt gttcctgttt cctcccaaac ccaaggacac cctgatgatc     1440

tccaggaccc ccgaggtgac atgcgtcgtg gtggacgtga gccacgagga ccccgaggtc     1500

aagttcaact ggtacgtcga tggcgtggag gtccacaatg ccaagaccaa gcccagggag     1560

gagcaatata actccaccta cagggtggtc agcgtgctca cagtgctgca ccaggattgg     1620

ctgaacggca aagagtacaa gtgcaaggtc agcaacaaag ccctgcctgc ccccatcgag     1680

aaaaccatct ccaaggctaa gggccagccc agggagcctc aggtgtacac actgcctcct     1740

agcagagagg agatgaccaa gaaccaggtc agcctctact gcctggtcaa aggcttctac     1800

ccctccgata ttgctgtgga atgggagtcc aacggccaac ccgagaacaa ctacaagacc     1860

acaccccctg tgctggacag cgacggttct tttttcctgt acagcaagct gaccgtcgat     1920

aagagcagat ggcagcaggg aaacgtgttc agctgttccg tcatgcacga ggccctgcac     1980

aaccactata cccagaaaag cctctccctg agccctggct gatgaagatc t              2031


<210>  39
<211>  670
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Translated insert of SEQ ID NO:38

<400>  39

Met Val Ser Gln Ala Leu Arg Leu Leu Cys Leu Leu Leu Gly Leu Gln 
1               5                   10                  15      


Gly Cys Leu Ala Ala Val Phe Val Thr Gln Glu Glu Ala His Gly Val 
            20                  25                  30          


Leu His Arg Arg Arg Arg Ala Asn Ala Phe Leu Glu Glu Leu Arg Pro 
        35                  40                  45              


Gly Ser Leu Glu Arg Glu Cys Lys Glu Glu Gln Cys Ser Phe Glu Glu 
    50                  55                  60                  


Ala Arg Glu Ile Phe Lys Asp Ala Glu Arg Thr Lys Leu Phe Trp Ile 
65                  70                  75                  80  


Ser Tyr Ser Asp Gly Asp Gln Cys Ala Ser Ser Pro Cys Gln Asn Gly 
                85                  90                  95      


Gly Ser Cys Lys Asp Gln Leu Gln Ser Tyr Ile Cys Phe Cys Leu Pro 
            100                 105                 110         


Ala Phe Glu Gly Arg Asn Cys Glu Thr His Lys Asp Asp Gln Leu Ile 
        115                 120                 125             


Cys Val Asn Glu Asn Gly Gly Cys Glu Gln Tyr Cys Ser Asp His Thr 
    130                 135                 140                 


Gly Thr Lys Arg Ser Cys Arg Cys His Glu Gly Tyr Ser Leu Leu Ala 
145                 150                 155                 160 


Asp Gly Val Ser Cys Thr Pro Thr Val Glu Tyr Pro Cys Gly Lys Ile 
                165                 170                 175     


Pro Ile Leu Glu Lys Arg Asn Ala Ser Lys Pro Gln Gly Arg Ile Val 
            180                 185                 190         


Gly Gly Lys Val Cys Pro Lys Gly Glu Cys Pro Trp Gln Val Leu Leu 
        195                 200                 205             


Leu Val Asn Gly Ala Gln Leu Cys Gly Gly Thr Leu Ile Asn Thr Ile 
    210                 215                 220                 


Trp Val Val Ser Ala Ala His Cys Phe Asp Lys Ile Lys Asn Trp Arg 
225                 230                 235                 240 


Asn Leu Ile Ala Val Leu Gly Glu His Asp Leu Ser Glu His Asp Gly 
                245                 250                 255     


Asp Glu Gln Ser Arg Arg Val Ala Gln Val Ile Ile Pro Ser Thr Tyr 
            260                 265                 270         


Val Pro Gly Thr Thr Asn His Asp Ile Ala Leu Leu Arg Leu His Gln 
        275                 280                 285             


Pro Val Val Leu Thr Asp His Val Val Pro Leu Cys Leu Pro Glu Arg 
    290                 295                 300                 


Thr Phe Ser Glu Arg Thr Leu Ala Phe Val Arg Phe Ser Leu Val Ser 
305                 310                 315                 320 


Gly Trp Gly Gln Leu Leu Asp Arg Gly Ala Thr Ala Leu Glu Leu Met 
                325                 330                 335     


Val Leu Asn Val Pro Arg Leu Met Thr Gln Asp Cys Leu Gln Gln Ser 
            340                 345                 350         


Arg Lys Val Gly Asp Ser Pro Asn Ile Thr Glu Tyr Met Phe Cys Ala 
        355                 360                 365             


Gly Tyr Ser Asp Gly Ser Lys Asp Ser Cys Ala Gly Asp Ser Gly Gly 
    370                 375                 380                 


Pro His Ala Thr His Tyr Arg Gly Thr Trp Tyr Leu Thr Gly Ile Val 
385                 390                 395                 400 


Ser Trp Gly Gln Gly Cys Ala Thr Val Gly His Phe Gly Val Tyr Thr 
                405                 410                 415     


Arg Val Ser Gln Tyr Ile Glu Trp Leu Gln Lys Leu Met Arg Ser Glu 
            420                 425                 430         


Pro Arg Pro Gly Val Leu Leu Arg Ala Pro Phe Pro Asp Lys Thr His 
        435                 440                 445             


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
    450                 455                 460                 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
465                 470                 475                 480 


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
                485                 490                 495     


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
            500                 505                 510         


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
        515                 520                 525             


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
    530                 535                 540                 


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
545                 550                 555                 560 


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
                565                 570                 575     


Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Tyr Cys Leu 
            580                 585                 590         


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
        595                 600                 605             


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
    610                 615                 620                 


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
625                 630                 635                 640 


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
                645                 650                 655     


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
            660                 665                 670 


<210>  40
<211>  8902
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleic acid sequence of pVITRO2 ICON Fc/knob and Fc/hole 
       (construct JT077)

<400>  40
cctgcaggcg ttacataact tacggtaaat ggcccgcctg gctgaccgcc caacgacccc       60

cgcccattga cgtcaataat gacgtatgtt cccatagtaa cgccaatagg gactttccat      120

tgacgtcaat gggtggagta tttacggtaa actgcccact tggcagtaca tcaagtgtat      180

catatgccaa gtacgccccc tattgacgtc aatgacggta aatggcccgc ctggcattat      240

gcccagtaca tgaccttatg ggactttcct acttggcagt acatctacgt attagtcatc      300

gctattacca tgatgatgcg gttttggcag tacatcaatg ggcgtggata gcggtttgac      360

tcacggggat ttccaagtct ccaccccatt gacgtcaatg ggagtttgtt ttgactagtc      420

agggccccaa cccccccaag cccccatttc acaacacgct ggcgctacag gcgcgtgact      480

tccccttgct ttggggcggg gggctgagac tcctatgtgc tccggattgg tcaggcacgg      540

ccttcggccc cgcctcctgc caccgcagat tggccgctag gcctccccga gcgccctgcc      600

tccgagggcc ggcgcaccat aaaagaagcc gccctagcca cgtcccctcg cagttcggcg      660

gtcccgcggg tctgtctcaa gcttgccgcc agaacacagg taagtgccgt gtgtggttcc      720

cgcgggcctg gcctctttac gggttatggc ccttgcgtgc cttgaattac ttccatgccc      780

ctggctgcag tacgtgattc ttgatcccga gcttcgggtt ggaagtgggt gggagagttc      840

gaggccttgc gcttaaggag ccccttcgcc tcgtgcttga gttgaggcct ggcttgggcg      900

ctggggccgc cgcgtgctaa tctggtggca ccttcgcgcc tgtctcgctg ctttcgctaa      960

gtctctagcc atttaaaatt tttgataacc agctgcgacg ctttttttct ggcgagatag     1020

tcttgtaaat gcgggccagg atctgcacac tggtatttcg gtttttgggg ccgcgggcgg     1080

cgacggggcc cgtgcgtccc agcgcacatg ttcggcgagg cggggcctgc gagcgcggcc     1140

accgagaatc ggacgggggt agtctcaaac tggccggcct gctctggtgc ctggcctcgc     1200

gccgccgtgt atcgccccgc cctgggcggc aaggctggcc cggtcggcac cagttgcgtg     1260

agcggaaaga tggccgcttc ccggccctgc tgcagggagc tcaaaatgga ggacgcggcg     1320

cccgggagag cgggcgggtg agtcacccac acaaaggaaa agggcctttc cttcctcatc     1380

cgtcgcttca tgtgactcca cggagtaccg ggcgccgtcc aggcacctcg attagttgtc     1440

gagcttttgg agtacgtcgt ctttaggttg gggggagggg ttttatgcga tggagtttcc     1500

ccacactgag tgggtggaga ctgaagagtt aggccagctt ggcacttgat gtaattctcc     1560

ttggaatttg ccctttttga gtttggatct tgcctcattc tcaagcctca gacagtggtt     1620

caaagttttt ttcttccatt tcaggtgtcg tgaaaactac ccctaaaagc caccggcgat     1680

cgatgcggcc gcaagcttac catggagtgg tcctgggtgt ttctgttctt cctgagcgtg     1740

accaccggag tgcacagcga caagacccac acctgtcccc cttgtcctgc ccccgaactg     1800

ctgggaggcc cttccgtgtt cctgtttcct cccaagccca aggacaccct gatgatcagc     1860

aggacccccg aggtgacctg tgtggtcgtg gacgtgtccc acgaggaccc tgaggtgaag     1920

ttcaactggt acgtggacgg cgtggaggtg cacaacgcca agacaaagcc ccgtgaggag     1980

cagtacaaca gcacctacag ggtggtgtcc gtgctgacag tgctgcacca ggactggctg     2040

aatggcaagg agtacaagtg caaagtgagc aacaaggccc tgcccgcccc cattgagaag     2100

accatcagca aggccaaggg ccagcccaga gagcctcagg tgtacacact gcccccctcc     2160

agggaggaga tgaccaagaa ccaggtgagc ctgacctgtc tggtgaaggg cttctaccct     2220

agcgacatcg ccgtggagtg ggaaagcaac ggccagcccg agaacaacta caagacaacc     2280

ccccctgtgc tggacagcga tggctccttc ttcctgacaa gcaagctgac agtggacaag     2340

agcaggtggc agcagggcaa cgtcttctcc tgcagcgtga tgcacgaagc cctgcacaac     2400

cactacaccc agaagagcct gagcctgagc cccggctgat gatctagact cgaggctagc     2460

tggccagaca tgataagata cattgatgag tttggacaaa ccacaactag aatgcagtga     2520

aaaaaatgct ttatttgtga aatttgtgat gctattgctt tatttgtaac cattataagc     2580

tgcaataaac aagttaacaa caacaattgc attcatttta tgtttcaggt tcagggggag     2640

gtgtgggagg ttttttaaag caagtaaaac ctctacaaat gtggtatgga aatgttaatt     2700

aactagccat gaccaaaatc ccttaacgtg agttttcgtt ccactgagcg tcagaccccg     2760

tagaaaagat caaaggatct tcttgagatc ctttttttct gcgcgtaatc tgctgcttgc     2820

aaacaaaaaa accaccgcta ccagcggtgg tttgtttgcc ggatcaagag ctaccaactc     2880

tttttccgaa ggtaactggc ttcagcagag cgcagatacc aaatactgtt cttctagtgt     2940

agccgtagtt aggccaccac ttcaagaact ctgtagcacc gcctacatac ctcgctctgc     3000

taatcctgtt accagtggct gctgccagtg gcgataagtc gtgtcttacc gggttggact     3060

caagacgata gttaccggat aaggcgcagc ggtcgggctg aacggggggt tcgtgcacac     3120

agcccagctt ggagcgaacg acctacaccg aactgagata cctacagcgt gagctatgag     3180

aaagcgccac gcttcccgaa gggagaaagg cggacaggta tccggtaagc ggcagggtcg     3240

gaacaggaga gcgcacgagg gagcttccag ggggaaacgc ctggtatctt tatagtcctg     3300

tcgggtttcg ccacctctga cttgagcgtc gatttttgtg atgctcgtca ggggggcgga     3360

gcctatggaa aaacgccagc aacgcggcct ttttacggtt cctggccttt tgctggcctt     3420

ttgctcacat gttcttaatt aacctgcagg gcctgaaata acctctgaaa gaggaacttg     3480

gttaggtacc ttctgaggct gaaagaacca gctgtggaat gtgtgtcagt tagggtgtgg     3540

aaagtcccca ggctccccag caggcagaag tatgcaaagc atgcatctca attagtcagc     3600

aaccaggtgt ggaaagtccc caggctcccc agcaggcaga agtatgcaaa gcatgcatct     3660

caattagtca gcaaccatag tcccactagt tccgccagag cgcgcgaggg cctccagcgg     3720

ccgcccctcc cccacagcag gggcggggtc ccgcgcccac cggaaggagc gggctcgggg     3780

cgggcggcgc tgattggccg gggcgggcct gacgccgacg cggctataag agaccacaag     3840

cgacccgcag ggccagacgt tcttcgccga agcttgccgt cagaacgcag gtgaggggcg     3900

ggtgtggctt ccgcgggccg ccgagctgga ggtcctgctc cgagcgggcc gggccccgct     3960

gtcgtcggcg gggattagct gcgagcattc ccgcttcgag ttgcgggcgg cgcgggaggc     4020

agagtgcgag gcctagcggc aaccccgtag cctcgcctcg tgtccggctt gaggcctagc     4080

gtggtgtccg cgccgccgcc gcgtgctact ccggccgcac tctggtcttt tttttttttg     4140

ttgttgttgc cctgctgcct tcgattgccg ttcagcaata ggggctaaca aagggagggt     4200

gcggggcttg ctcgcccgga gcccggagag gtcatggttg gggaggaatg gagggacagg     4260

agtggcggct ggggcccgcc cgccttcgga gcacatgtcc gacgccacct ggatggggcg     4320

aggcctgggg tttttcccga agcaaccagg ctggggttag cgtgccgagg ccatgtggcc     4380

ccagcacccg gcacgatctg gcttggcggc gccgcgttgc cctgcctccc taactagggt     4440

gaggccatcc cgtccggcac cagttgcgtg cgtggaaaga tggccgctcc cgggccctgt     4500

tgcaaggagc tcaaaatgga ggacgcggca gcccggtgga gcgggcgggt gagtcaccca     4560

cacaaaggaa gagggcctgg tccctcaccg gctgctgctt cctgtgaccc cgtggtccta     4620

tcggccgcaa tagtcacctc gggcttttga gcacggctag tcgcggcggg gggaggggat     4680

gtaatggcgt tggagtttgt tcacatttgg tgggtggaga ctagtcaggc cagcctggcg     4740

ctggaagtca tttttggaat ttgtcccctt gagttttgag cggagctaat tctcgggctt     4800

cttagcggtt caaaggtatc ttttaaaccc ttttttaggt gttgtgaaaa ccaccgctaa     4860

ttcaaagcaa ccggtgtcga cggtaccacc atggtcagcc aggccctcag gctgctctgt     4920

ctcctgctgg gcctccaggg ctgtctggct gccgtcttcg tgacccagga ggaggctcac     4980

ggcgtgctcc acaggaggag aagagctaac gctttcctcg aagagctgag gcccggcagc     5040

ctggaaaggg agtgcaaaga ggagcagtgc agcttcgaag aagccaggga aattttcaag     5100

gacgccgaga ggaccaagct gttctggatc tcctatagcg acggcgatca gtgcgcttcc     5160

agcccctgcc agaacggagg ctcctgcaag gatcagctgc agtcctacat ttgcttctgt     5220

ctgcccgcct ttgagggcag aaactgtgag acccacaagg atgaccagct gatttgtgtg     5280

aatgagaacg gcggatgcga acagtactgc tccgaccata ccggaacaaa gaggtcctgc     5340

agatgccatg agggctacag cctgctggcc gatggagtga gctgcacccc caccgtggaa     5400

tacccctgcg gcaaaatccc catcctggag aagaggaatg ccagcaaacc ccagggcagg     5460

attgtgggcg gaaaggtgtg ccccaaagga gagtgtcctt ggcaggtgct gctgctcgtg     5520

aacggagccc agctgtgcgg cggcacactc atcaatacca tctgggtggt cagcgccgcc     5580

cactgctttg acaagatcaa gaactggagg aacctcatcg ccgtgctggg agagcacgat     5640

ctgagcgagc atgacggcga cgaacagtcc aggagagtgg cccaggtgat catccctagc     5700

acatatgtcc ccggcaccac caaccatgat atcgccctcc tcaggctgca tcagcccgtg     5760

gtgctgacag accacgtggt gcctctctgc ctgcccgaga ggaccttcag cgagaggacc     5820

ctggccttcg tgagattcag cctggtgagc ggatggggcc agctcctgga tagaggcgcc     5880

acagccctgg agctgatggt gctgaacgtg cctagactga tgacccaaga ttgcctccag     5940

cagagcagga aggtgggaga ctcccccaat atcacagagt atatgttttg cgccggctac     6000

agcgatggtt ctaaagattc ctgtgctggc gacagcggag gcccccacgc tacccactac     6060

agaggcacat ggtatttaac cggaatcgtg tcctggggac aaggctgcgc caccgtgggc     6120

catttcggcg tgtacaccag ggtcagccag tacatcgaat ggctgcagaa actcatgagg     6180

tccgagccta gacccggcgt cctgctgaga gcccctttcc ctgataaaac acacacctgt     6240

cccccttgtc ctgctcctga gctcctgggc ggaccttccg tgttcctgtt tcctcccaaa     6300

cccaaggaca ccctgatgat ctccaggacc cccgaggtga catgcgtcgt ggtggacgtg     6360

agccacgagg accccgaggt caagttcaac tggtacgtcg atggcgtgga ggtccacaat     6420

gccaagacca agcccaggga ggagcaatat aactccacct acagggtggt cagcgtgctc     6480

acagtgctgc accaggattg gctgaacggc aaagagtaca agtgcaaggt cagcaacaaa     6540

gccctgcctg cccccatcga gaaaaccatc tccaaggcta agggccagcc cagggagcct     6600

caggtgtaca cactgcctcc tagcagagag gagatgacca agaaccaggt cagcctctac     6660

tgcctggtca aaggcttcta cccctccgat attgctgtgg aatgggagtc caacggccaa     6720

cccgagaaca actacaagac cacaccccct gtgctggaca gcgacggttc ttttttcctg     6780

tacagcaagc tgaccgtcga taagagcaga tggcagcagg gaaacgtgtt cagctgttcc     6840

gtcatgcacg aggccctgca caaccactat acccagaaaa gcctctccct gagccctggc     6900

tgatgaagat ctggatccac gcgtatcgat tgtcgaccct aggagcaggt ttccccaatg     6960

acacaaaacg tgcaacttga aactccgcct ggtctttcca ggtctagagg ggtaacactt     7020

tgtactgcgt ttggctccac gctcgatcca ctggcgagtg ttagtaacag cactgttgct     7080

tcgtagcgga gcatgacggc cgtgggaact cctccttggt aacaaggacc cacggggcca     7140

aaagccacgc ccacacgggc ccgtcatgtg tgcaacccca gcacggcgac tttactgcga     7200

aacccacttt aaagtgacat tgaaactggt acccacacac tggtgacagg ctaaggatgc     7260

ccttcaggta ccccgaggta acacgcgaca ctcgggatct gagaagggga ctggggcttc     7320

tataaaagcg ctcggtttaa aaagcttcta tgcctgaata ggtgaccgga ggtcggcacc     7380

tttcctttgc aattactgac cctatgaata caactgactg tttgacaatt aatcatcggc     7440

atagtatatc ggcatagtat aatacgactc actataggag ggccaccatg attgaacaag     7500

atggattgca cgcaggttct ccggccgctt gggtggagag gctattcggc tatgactggg     7560

cacaacagac aatcggctgc tctgatgccg ccgtgttccg gctgtcagcg caggggcgcc     7620

cggttctttt tgtcaagacc gacctgtccg gtgccctgaa tgaactgcaa gacgaggcag     7680

cgcggctatc gtggctggcc acgacgggcg ttccttgcgc agctgtgctc gacgttgtca     7740

ctgaagcggg aagggactgg ctgctattgg gcgaagtgcc ggggcaggat ctcctgtcat     7800

ctcaccttgc tcctgccgag aaagtatcca tcatggctga tgcaatgcgg cggctgcata     7860

cgcttgatcc ggctacctgc ccattcgacc accaagcgaa acatcgcatc gagcgagcac     7920

gtactcggat ggaagccggt cttgtcgatc aggatgatct ggacgaagag catcaggggc     7980

tcgcgccagc cgaactgttc gccaggctca aggcgagcat gcccgacggc gaggatctcg     8040

tcgtgacaca tggcgatgcc tgcttgccga atatcatggt ggaaaatggc cgcttttctg     8100

gattcatcga ctgtggccgg ctgggtgtgg cggaccgcta tcaggacata gcgttggcta     8160

cccgtgatat tgctgaagag cttggcggcg aatgggctga ccgcttcctc gtgctttacg     8220

gtatcgccgc tcccgattcg cagcgcatcg ccttctatcg ccttcttgac gagttcttct     8280

gagcgggact ctggggttcg aaatgaccga ccaagcgaat tcgctaggat tatccctaat     8340

acctgccacc ccactcttaa tcagtggtgg aagaacggtc tcagaactgt ttgtttcaat     8400

tggccattta agtttagtag taaaagactg gttaatgata acaatgcatc gtaaaacctt     8460

cagaaggaaa ggagaatgtt ttgtggacca ctttggtttt cttttttgcg tgtggcagtt     8520

ttaagttatt agtttttaaa atcagtactt tttaatggaa acaacttgac caaaaatttg     8580

tcacagaatt ttgagaccca ttaaaaaagt taaatgagaa acctgtgtgt tcctttggtc     8640

aacaccgaga catttaggtg aaagacatct aattctggtt ttacgaatct ggaaacttct     8700

tgaaaatgta attcttgagt taacacttct gggtggagaa tagggttgtt ttccccccac     8760

ataattggaa ggggaaggaa tatcatttaa agctatggga gggttgcttt gattacaaca     8820

ctggagagaa atgcagcatg ttgctgattg cctgtcacta aaacaggcca aaaactgagt     8880

ccttgggttg catagaaagc tg                                              8902


<210>  41
<211>  4869
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  5' Vector of the construct of SEQ ID NO:40

<400>  41
cctgcaggcg ttacataact tacggtaaat ggcccgcctg gctgaccgcc caacgacccc       60

cgcccattga cgtcaataat gacgtatgtt cccatagtaa cgccaatagg gactttccat      120

tgacgtcaat gggtggagta tttacggtaa actgcccact tggcagtaca tcaagtgtat      180

catatgccaa gtacgccccc tattgacgtc aatgacggta aatggcccgc ctggcattat      240

gcccagtaca tgaccttatg ggactttcct acttggcagt acatctacgt attagtcatc      300

gctattacca tgatgatgcg gttttggcag tacatcaatg ggcgtggata gcggtttgac      360

tcacggggat ttccaagtct ccaccccatt gacgtcaatg ggagtttgtt ttgactagtc      420

agggccccaa cccccccaag cccccatttc acaacacgct ggcgctacag gcgcgtgact      480

tccccttgct ttggggcggg gggctgagac tcctatgtgc tccggattgg tcaggcacgg      540

ccttcggccc cgcctcctgc caccgcagat tggccgctag gcctccccga gcgccctgcc      600

tccgagggcc ggcgcaccat aaaagaagcc gccctagcca cgtcccctcg cagttcggcg      660

gtcccgcggg tctgtctcaa gcttgccgcc agaacacagg taagtgccgt gtgtggttcc      720

cgcgggcctg gcctctttac gggttatggc ccttgcgtgc cttgaattac ttccatgccc      780

ctggctgcag tacgtgattc ttgatcccga gcttcgggtt ggaagtgggt gggagagttc      840

gaggccttgc gcttaaggag ccccttcgcc tcgtgcttga gttgaggcct ggcttgggcg      900

ctggggccgc cgcgtgctaa tctggtggca ccttcgcgcc tgtctcgctg ctttcgctaa      960

gtctctagcc atttaaaatt tttgataacc agctgcgacg ctttttttct ggcgagatag     1020

tcttgtaaat gcgggccagg atctgcacac tggtatttcg gtttttgggg ccgcgggcgg     1080

cgacggggcc cgtgcgtccc agcgcacatg ttcggcgagg cggggcctgc gagcgcggcc     1140

accgagaatc ggacgggggt agtctcaaac tggccggcct gctctggtgc ctggcctcgc     1200

gccgccgtgt atcgccccgc cctgggcggc aaggctggcc cggtcggcac cagttgcgtg     1260

agcggaaaga tggccgcttc ccggccctgc tgcagggagc tcaaaatgga ggacgcggcg     1320

cccgggagag cgggcgggtg agtcacccac acaaaggaaa agggcctttc cttcctcatc     1380

cgtcgcttca tgtgactcca cggagtaccg ggcgccgtcc aggcacctcg attagttgtc     1440

gagcttttgg agtacgtcgt ctttaggttg gggggagggg ttttatgcga tggagtttcc     1500

ccacactgag tgggtggaga ctgaagagtt aggccagctt ggcacttgat gtaattctcc     1560

ttggaatttg ccctttttga gtttggatct tgcctcattc tcaagcctca gacagtggtt     1620

caaagttttt ttcttccatt tcaggtgtcg tgaaaactac ccctaaaagc caccggcgat     1680

cgatgcggcc gcaagcttac catggagtgg tcctgggtgt ttctgttctt cctgagcgtg     1740

accaccggag tgcacagcga caagacccac acctgtcccc cttgtcctgc ccccgaactg     1800

ctgggaggcc cttccgtgtt cctgtttcct cccaagccca aggacaccct gatgatcagc     1860

aggacccccg aggtgacctg tgtggtcgtg gacgtgtccc acgaggaccc tgaggtgaag     1920

ttcaactggt acgtggacgg cgtggaggtg cacaacgcca agacaaagcc ccgtgaggag     1980

cagtacaaca gcacctacag ggtggtgtcc gtgctgacag tgctgcacca ggactggctg     2040

aatggcaagg agtacaagtg caaagtgagc aacaaggccc tgcccgcccc cattgagaag     2100

accatcagca aggccaaggg ccagcccaga gagcctcagg tgtacacact gcccccctcc     2160

agggaggaga tgaccaagaa ccaggtgagc ctgacctgtc tggtgaaggg cttctaccct     2220

agcgacatcg ccgtggagtg ggaaagcaac ggccagcccg agaacaacta caagacaacc     2280

ccccctgtgc tggacagcga tggctccttc ttcctgacaa gcaagctgac agtggacaag     2340

agcaggtggc agcagggcaa cgtcttctcc tgcagcgtga tgcacgaagc cctgcacaac     2400

cactacaccc agaagagcct gagcctgagc cccggctgat gatctagact cgaggctagc     2460

tggccagaca tgataagata cattgatgag tttggacaaa ccacaactag aatgcagtga     2520

aaaaaatgct ttatttgtga aatttgtgat gctattgctt tatttgtaac cattataagc     2580

tgcaataaac aagttaacaa caacaattgc attcatttta tgtttcaggt tcagggggag     2640

gtgtgggagg ttttttaaag caagtaaaac ctctacaaat gtggtatgga aatgttaatt     2700

aactagccat gaccaaaatc ccttaacgtg agttttcgtt ccactgagcg tcagaccccg     2760

tagaaaagat caaaggatct tcttgagatc ctttttttct gcgcgtaatc tgctgcttgc     2820

aaacaaaaaa accaccgcta ccagcggtgg tttgtttgcc ggatcaagag ctaccaactc     2880

tttttccgaa ggtaactggc ttcagcagag cgcagatacc aaatactgtt cttctagtgt     2940

agccgtagtt aggccaccac ttcaagaact ctgtagcacc gcctacatac ctcgctctgc     3000

taatcctgtt accagtggct gctgccagtg gcgataagtc gtgtcttacc gggttggact     3060

caagacgata gttaccggat aaggcgcagc ggtcgggctg aacggggggt tcgtgcacac     3120

agcccagctt ggagcgaacg acctacaccg aactgagata cctacagcgt gagctatgag     3180

aaagcgccac gcttcccgaa gggagaaagg cggacaggta tccggtaagc ggcagggtcg     3240

gaacaggaga gcgcacgagg gagcttccag ggggaaacgc ctggtatctt tatagtcctg     3300

tcgggtttcg ccacctctga cttgagcgtc gatttttgtg atgctcgtca ggggggcgga     3360

gcctatggaa aaacgccagc aacgcggcct ttttacggtt cctggccttt tgctggcctt     3420

ttgctcacat gttcttaatt aacctgcagg gcctgaaata acctctgaaa gaggaacttg     3480

gttaggtacc ttctgaggct gaaagaacca gctgtggaat gtgtgtcagt tagggtgtgg     3540

aaagtcccca ggctccccag caggcagaag tatgcaaagc atgcatctca attagtcagc     3600

aaccaggtgt ggaaagtccc caggctcccc agcaggcaga agtatgcaaa gcatgcatct     3660

caattagtca gcaaccatag tcccactagt tccgccagag cgcgcgaggg cctccagcgg     3720

ccgcccctcc cccacagcag gggcggggtc ccgcgcccac cggaaggagc gggctcgggg     3780

cgggcggcgc tgattggccg gggcgggcct gacgccgacg cggctataag agaccacaag     3840

cgacccgcag ggccagacgt tcttcgccga agcttgccgt cagaacgcag gtgaggggcg     3900

ggtgtggctt ccgcgggccg ccgagctgga ggtcctgctc cgagcgggcc gggccccgct     3960

gtcgtcggcg gggattagct gcgagcattc ccgcttcgag ttgcgggcgg cgcgggaggc     4020

agagtgcgag gcctagcggc aaccccgtag cctcgcctcg tgtccggctt gaggcctagc     4080

gtggtgtccg cgccgccgcc gcgtgctact ccggccgcac tctggtcttt tttttttttg     4140

ttgttgttgc cctgctgcct tcgattgccg ttcagcaata ggggctaaca aagggagggt     4200

gcggggcttg ctcgcccgga gcccggagag gtcatggttg gggaggaatg gagggacagg     4260

agtggcggct ggggcccgcc cgccttcgga gcacatgtcc gacgccacct ggatggggcg     4320

aggcctgggg tttttcccga agcaaccagg ctggggttag cgtgccgagg ccatgtggcc     4380

ccagcacccg gcacgatctg gcttggcggc gccgcgttgc cctgcctccc taactagggt     4440

gaggccatcc cgtccggcac cagttgcgtg cgtggaaaga tggccgctcc cgggccctgt     4500

tgcaaggagc tcaaaatgga ggacgcggca gcccggtgga gcgggcgggt gagtcaccca     4560

cacaaaggaa gagggcctgg tccctcaccg gctgctgctt cctgtgaccc cgtggtccta     4620

tcggccgcaa tagtcacctc gggcttttga gcacggctag tcgcggcggg gggaggggat     4680

gtaatggcgt tggagtttgt tcacatttgg tgggtggaga ctagtcaggc cagcctggcg     4740

ctggaagtca tttttggaat ttgtcccctt gagttttgag cggagctaat tctcgggctt     4800

cttagcggtt caaaggtatc ttttaaaccc ttttttaggt gttgtgaaaa ccaccgctaa     4860

ttcaaagca                                                             4869


<210>  42
<211>  1984
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3' Vector of the construct of SEQ ID NO:40

<400>  42
acgcgtatcg attgtcgacc ctaggagcag gtttccccaa tgacacaaaa cgtgcaactt       60

gaaactccgc ctggtctttc caggtctaga ggggtaacac tttgtactgc gtttggctcc      120

acgctcgatc cactggcgag tgttagtaac agcactgttg cttcgtagcg gagcatgacg      180

gccgtgggaa ctcctccttg gtaacaagga cccacggggc caaaagccac gcccacacgg      240

gcccgtcatg tgtgcaaccc cagcacggcg actttactgc gaaacccact ttaaagtgac      300

attgaaactg gtacccacac actggtgaca ggctaaggat gcccttcagg taccccgagg      360

taacacgcga cactcgggat ctgagaaggg gactggggct tctataaaag cgctcggttt      420

aaaaagcttc tatgcctgaa taggtgaccg gaggtcggca cctttccttt gcaattactg      480

accctatgaa tacaactgac tgtttgacaa ttaatcatcg gcatagtata tcggcatagt      540

ataatacgac tcactatagg agggccacca tgattgaaca agatggattg cacgcaggtt      600

ctccggccgc ttgggtggag aggctattcg gctatgactg ggcacaacag acaatcggct      660

gctctgatgc cgccgtgttc cggctgtcag cgcaggggcg cccggttctt tttgtcaaga      720

ccgacctgtc cggtgccctg aatgaactgc aagacgaggc agcgcggcta tcgtggctgg      780

ccacgacggg cgttccttgc gcagctgtgc tcgacgttgt cactgaagcg ggaagggact      840

ggctgctatt gggcgaagtg ccggggcagg atctcctgtc atctcacctt gctcctgccg      900

agaaagtatc catcatggct gatgcaatgc ggcggctgca tacgcttgat ccggctacct      960

gcccattcga ccaccaagcg aaacatcgca tcgagcgagc acgtactcgg atggaagccg     1020

gtcttgtcga tcaggatgat ctggacgaag agcatcaggg gctcgcgcca gccgaactgt     1080

tcgccaggct caaggcgagc atgcccgacg gcgaggatct cgtcgtgaca catggcgatg     1140

cctgcttgcc gaatatcatg gtggaaaatg gccgcttttc tggattcatc gactgtggcc     1200

ggctgggtgt ggcggaccgc tatcaggaca tagcgttggc tacccgtgat attgctgaag     1260

agcttggcgg cgaatgggct gaccgcttcc tcgtgcttta cggtatcgcc gctcccgatt     1320

cgcagcgcat cgccttctat cgccttcttg acgagttctt ctgagcggga ctctggggtt     1380

cgaaatgacc gaccaagcga attcgctagg attatcccta atacctgcca ccccactctt     1440

aatcagtggt ggaagaacgg tctcagaact gtttgtttca attggccatt taagtttagt     1500

agtaaaagac tggttaatga taacaatgca tcgtaaaacc ttcagaagga aaggagaatg     1560

ttttgtggac cactttggtt ttcttttttg cgtgtggcag ttttaagtta ttagttttta     1620

aaatcagtac tttttaatgg aaacaacttg accaaaaatt tgtcacagaa ttttgagacc     1680

cattaaaaaa gttaaatgag aaacctgtgt gttcctttgg tcaacaccga gacatttagg     1740

tgaaagacat ctaattctgg ttttacgaat ctggaaactt cttgaaaatg taattcttga     1800

gttaacactt ctgggtggag aatagggttg ttttcccccc acataattgg aaggggaagg     1860

aatatcattt aaagctatgg gagggttgct ttgattacaa cactggagag aaatgcagca     1920

tgttgctgat tgcctgtcac taaaacaggc caaaaactga gtccttgggt tgcatagaaa     1980

gctg                                                                  1984


<210>  43
<211>  2049
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Insert of the construct of SEQ ID NO:40

<400>  43
accggtgtcg acggtaccac catggtcagc caggccctca ggctgctctg tctcctgctg       60

ggcctccagg gctgtctggc tgccgtcttc gtgacccagg aggaggctca cggcgtgctc      120

cacaggagga gaagagctaa cgctttcctc gaagagctga ggcccggcag cctggaaagg      180

gagtgcaaag aggagcagtg cagcttcgaa gaagccaggg aaattttcaa ggacgccgag      240

aggaccaagc tgttctggat ctcctatagc gacggcgatc agtgcgcttc cagcccctgc      300

cagaacggag gctcctgcaa ggatcagctg cagtcctaca tttgcttctg tctgcccgcc      360

tttgagggca gaaactgtga gacccacaag gatgaccagc tgatttgtgt gaatgagaac      420

ggcggatgcg aacagtactg ctccgaccat accggaacaa agaggtcctg cagatgccat      480

gagggctaca gcctgctggc cgatggagtg agctgcaccc ccaccgtgga atacccctgc      540

ggcaaaatcc ccatcctgga gaagaggaat gccagcaaac cccagggcag gattgtgggc      600

ggaaaggtgt gccccaaagg agagtgtcct tggcaggtgc tgctgctcgt gaacggagcc      660

cagctgtgcg gcggcacact catcaatacc atctgggtgg tcagcgccgc ccactgcttt      720

gacaagatca agaactggag gaacctcatc gccgtgctgg gagagcacga tctgagcgag      780

catgacggcg acgaacagtc caggagagtg gcccaggtga tcatccctag cacatatgtc      840

cccggcacca ccaaccatga tatcgccctc ctcaggctgc atcagcccgt ggtgctgaca      900

gaccacgtgg tgcctctctg cctgcccgag aggaccttca gcgagaggac cctggccttc      960

gtgagattca gcctggtgag cggatggggc cagctcctgg atagaggcgc cacagccctg     1020

gagctgatgg tgctgaacgt gcctagactg atgacccaag attgcctcca gcagagcagg     1080

aaggtgggag actcccccaa tatcacagag tatatgtttt gcgccggcta cagcgatggt     1140

tctaaagatt cctgtgctgg cgacagcgga ggcccccacg ctacccacta cagaggcaca     1200

tggtatttaa ccggaatcgt gtcctgggga caaggctgcg ccaccgtggg ccatttcggc     1260

gtgtacacca gggtcagcca gtacatcgaa tggctgcaga aactcatgag gtccgagcct     1320

agacccggcg tcctgctgag agcccctttc cctgataaaa cacacacctg tcccccttgt     1380

cctgctcctg agctcctggg cggaccttcc gtgttcctgt ttcctcccaa acccaaggac     1440

accctgatga tctccaggac ccccgaggtg acatgcgtcg tggtggacgt gagccacgag     1500

gaccccgagg tcaagttcaa ctggtacgtc gatggcgtgg aggtccacaa tgccaagacc     1560

aagcccaggg aggagcaata taactccacc tacagggtgg tcagcgtgct cacagtgctg     1620

caccaggatt ggctgaacgg caaagagtac aagtgcaagg tcagcaacaa agccctgcct     1680

gcccccatcg agaaaaccat ctccaaggct aagggccagc ccagggagcc tcaggtgtac     1740

acactgcctc ctagcagaga ggagatgacc aagaaccagg tcagcctcta ctgcctggtc     1800

aaaggcttct acccctccga tattgctgtg gaatgggagt ccaacggcca acccgagaac     1860

aactacaaga ccacaccccc tgtgctggac agcgacggtt cttttttcct gtacagcaag     1920

ctgaccgtcg ataagagcag atggcagcag ggaaacgtgt tcagctgttc cgtcatgcac     1980

gaggccctgc acaaccacta tacccagaaa agcctctccc tgagccctgg ctgatgaaga     2040

tctggatcc                                                             2049


<210>  44
<211>  670
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Translated insert of SEQ ID NO:43

<400>  44

Met Val Ser Gln Ala Leu Arg Leu Leu Cys Leu Leu Leu Gly Leu Gln 
1               5                   10                  15      


Gly Cys Leu Ala Ala Val Phe Val Thr Gln Glu Glu Ala His Gly Val 
            20                  25                  30          


Leu His Arg Arg Arg Arg Ala Asn Ala Phe Leu Glu Glu Leu Arg Pro 
        35                  40                  45              


Gly Ser Leu Glu Arg Glu Cys Lys Glu Glu Gln Cys Ser Phe Glu Glu 
    50                  55                  60                  


Ala Arg Glu Ile Phe Lys Asp Ala Glu Arg Thr Lys Leu Phe Trp Ile 
65                  70                  75                  80  


Ser Tyr Ser Asp Gly Asp Gln Cys Ala Ser Ser Pro Cys Gln Asn Gly 
                85                  90                  95      


Gly Ser Cys Lys Asp Gln Leu Gln Ser Tyr Ile Cys Phe Cys Leu Pro 
            100                 105                 110         


Ala Phe Glu Gly Arg Asn Cys Glu Thr His Lys Asp Asp Gln Leu Ile 
        115                 120                 125             


Cys Val Asn Glu Asn Gly Gly Cys Glu Gln Tyr Cys Ser Asp His Thr 
    130                 135                 140                 


Gly Thr Lys Arg Ser Cys Arg Cys His Glu Gly Tyr Ser Leu Leu Ala 
145                 150                 155                 160 


Asp Gly Val Ser Cys Thr Pro Thr Val Glu Tyr Pro Cys Gly Lys Ile 
                165                 170                 175     


Pro Ile Leu Glu Lys Arg Asn Ala Ser Lys Pro Gln Gly Arg Ile Val 
            180                 185                 190         


Gly Gly Lys Val Cys Pro Lys Gly Glu Cys Pro Trp Gln Val Leu Leu 
        195                 200                 205             


Leu Val Asn Gly Ala Gln Leu Cys Gly Gly Thr Leu Ile Asn Thr Ile 
    210                 215                 220                 


Trp Val Val Ser Ala Ala His Cys Phe Asp Lys Ile Lys Asn Trp Arg 
225                 230                 235                 240 


Asn Leu Ile Ala Val Leu Gly Glu His Asp Leu Ser Glu His Asp Gly 
                245                 250                 255     


Asp Glu Gln Ser Arg Arg Val Ala Gln Val Ile Ile Pro Ser Thr Tyr 
            260                 265                 270         


Val Pro Gly Thr Thr Asn His Asp Ile Ala Leu Leu Arg Leu His Gln 
        275                 280                 285             


Pro Val Val Leu Thr Asp His Val Val Pro Leu Cys Leu Pro Glu Arg 
    290                 295                 300                 


Thr Phe Ser Glu Arg Thr Leu Ala Phe Val Arg Phe Ser Leu Val Ser 
305                 310                 315                 320 


Gly Trp Gly Gln Leu Leu Asp Arg Gly Ala Thr Ala Leu Glu Leu Met 
                325                 330                 335     


Val Leu Asn Val Pro Arg Leu Met Thr Gln Asp Cys Leu Gln Gln Ser 
            340                 345                 350         


Arg Lys Val Gly Asp Ser Pro Asn Ile Thr Glu Tyr Met Phe Cys Ala 
        355                 360                 365             


Gly Tyr Ser Asp Gly Ser Lys Asp Ser Cys Ala Gly Asp Ser Gly Gly 
    370                 375                 380                 


Pro His Ala Thr His Tyr Arg Gly Thr Trp Tyr Leu Thr Gly Ile Val 
385                 390                 395                 400 


Ser Trp Gly Gln Gly Cys Ala Thr Val Gly His Phe Gly Val Tyr Thr 
                405                 410                 415     


Arg Val Ser Gln Tyr Ile Glu Trp Leu Gln Lys Leu Met Arg Ser Glu 
            420                 425                 430         


Pro Arg Pro Gly Val Leu Leu Arg Ala Pro Phe Pro Asp Lys Thr His 
        435                 440                 445             


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
    450                 455                 460                 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
465                 470                 475                 480 


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
                485                 490                 495     


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
            500                 505                 510         


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
        515                 520                 525             


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
    530                 535                 540                 


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
545                 550                 555                 560 


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
                565                 570                 575     


Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Tyr Cys Leu 
            580                 585                 590         


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
        595                 600                 605             


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
    610                 615                 620                 


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
625                 630                 635                 640 


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
                645                 650                 655     


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
            660                 665                 670 


<210>  45
<211>  4300
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleic acid sequence of pSELECT-neo Fc/hole (construct JT090)

<400>  45
gcggccgcaa taaaatatct ttattttcat tacatctgtg tgttggtttt ttgtgtgaat       60

cgtaactaac atacgctctc catcaaaaca aaacgaaaca aaacaaacta gcaaaatagg      120

ctgtccccag tgcaagtgca ggtgccagaa catttctcta tcgaaggatc tgcgatcgct      180

ccggtgcccg tcagtgggca gagcgcacat cgcccacagt ccccgagaag ttggggggag      240

gggtcggcaa ttgaacgggt gcctagagaa ggtggcgcgg ggtaaactgg gaaagtgatg      300

tcgtgtactg gctccgcctt tttcccgagg gtgggggaga accgtatata agtgcagtag      360

tcgccgtgaa cgttcttttt cgcaacgggt ttgccgccag aacacagctg aagcttcgag      420

gggctcgcat ctctccttca cgcgcccgcc gccctacctg aggccgccat ccacgccggt      480

tgagtcgcgt tctgccgcct cccgcctgtg gtgcctcctg aactgcgtcc gccgtctagg      540

taagtttaaa gctcaggtcg agaccgggcc tttgtccggc gctcccttgg agcctaccta      600

gactcagccg gctctccacg ctttgcctga ccctgcttgc tcaactctac gtctttgttt      660

cgttttctgt tctgcgccgt tacagatcca agctgtgacc ggcgcctacc tgagatcacc      720

ggcgtgtcga caccatggag tggagctggg tgtttctgtt cttcctgagc gtgaccaccg      780

gcgttcattc cgacaagacc cacacatgtc ccccctgccc tgctcctgaa ctgctgggag      840

gccccagcgt gttcctgttt cctcccaagc ccaaggacac cctgatgatc agccggaccc      900

ctgaagtgac ctgcgtggtg gtggacgtgt cccacgagga ccccgaggtg aagttcaatt      960

ggtacgtgga cggcgtggaa gtccacaacg ctaagaccaa gccccgggag gaacagtaca     1020

acagcaccta ccgggtggtg tccgtgctga ccgtgctgca ccaggactgg ctgaacggca     1080

aggagtacaa gtgcaaagtg tccaacaagg ccctgcccgc ccccatcgag aagaccatca     1140

gcaaggccaa gggacagcct agggagcctc aggtctacac cctgccccct tccagggagg     1200

agatgaccaa gaatcaggtg tccctgacct gcctggtgaa gggcttctac cccagcgaca     1260

tcgccgtgga gtgggagagc aacggccagc ctgagaacaa ctacaagacc acccctcccg     1320

tgctggatag cgacggctcc ttcttcctga ccagcaaact gaccgtggac aagagcaggt     1380

ggcagcaggg caacgtgttc tcctgctccg tgatgcacga ggctctgcac aaccggttca     1440

cccagaagag cctgtccctg agccctggat gatgagctag ctggccagac atgataagat     1500

acattgatga gtttggacaa accacaacta gaatgcagtg aaaaaaatgc tttatttgtg     1560

aaatttgtga tgctattgct ttatttgtaa ccattataag ctgcaataaa caagttaaca     1620

acaacaattg cattcatttt atgtttcagg ttcaggggga ggtgtgggag gttttttaaa     1680

gcaagtaaaa cctctacaaa tgtggtatgg aattctaaaa tacagcatag caaaacttta     1740

acctccaaat caagcctcta cttgaatcct tttctgaggg atgaataagg cataggcatc     1800

aggggctgtt gccaatgtgc attagctgtt tgcagcctca ccttctttca tggagtttaa     1860

gatatagtgt attttcccaa ggtttgaact agctcttcat ttctttatgt tttaaatgca     1920

ctgacctccc acattccctt tttagtaaaa tattcagaaa taatttaaat acatcattgc     1980

aatgaaaata aatgtttttt attaggcaga atccagatgc tcaaggccct tcataatatc     2040

ccccagttta gtagttggac ttagggaaca aaggaacctt taatagaaat tggacagcaa     2100

gaaagcgagc ttctagcttt agaagaactc atcaagaagt ctgtagaagg caattctctg     2160

ggagtcaggg gctgcaatgc catagagcac taggaacctg tctgcccact ctccccctag     2220

ctcttctgct atgtccctgg ttgctagggc aatgtcctgg tacctgtcag ccactcccag     2280

cctgccacag tctatgaagc cagagaacct tccattttca accatgatgt tgggaaggca     2340

ggcatcccca tgagtcacca ctaggtcctc accatctggc atggatgcct tgagcctggc     2400

aaatagttca gcaggggcca ggccctggtg ttcttcatcc aagtcatctt ggtccaccag     2460

gccagcctcc atcctggttc tggccctctc tatcctgtgc ttggcctggt ggtcaaaggg     2520

gcaggtggct gggtcaaggg tgtggagtct tctcatggca tcagccatga ttgacacttt     2580

ctcagctgga gctaggtgag aggaaaggag gtcctgccca ggcacctcac ctagtaggag     2640

ccagtccctt ccagcttctg tgaccacatc aaggacagct gcacagggga ccccagttgt     2700

tgccaaccag gagagtctgg cagcctcatc ctggagctca ttgagagccc cactgaggtc     2760

tgtctttaca aaaaggactg gcctgccttg ggctgaaagt ctgaaaactg ctgcatcaga     2820

gcaaccaatg gtctgctgtg cccagtcata gccaaacagt ctctcaaccc aggcagctgg     2880

agaacctgca tgtaggccat cttgttcaat catgatggcc ctcctatagt gagtcgtatt     2940

atactatgcc gatatactat gccgatgatt aattgtcaaa acagcgtgga tggcgtctcc     3000

agcttatctg acggttcact aaacgagctc tgcttatata gacctcccac cgtacacgcc     3060

taccgcccat ttgcgtcaat ggggcggagt tgttacgaca ttttggaaag tcccgttgat     3120

ttactagtca aaacaaactc ccattgacgt caatggggtg gagacttgga aatccccgtg     3180

agtcaaaccg ctatccacgc ccattgatgt actgccaaaa ccgcatcatc atggtaatag     3240

cgatgactaa tacgtagatg tactgccaag taggaaagtc ccataaggtc atgtactggg     3300

cataatgcca ggcgggccat ttaccgtcat tgacgtcaat agggggcgta cttggcatat     3360

gatacacttg atgtactgcc aagtgggcag tttaccgtaa atactccacc cattgacgtc     3420

aatggaaagt ccctattggc gttactatgg gaacatacgt cattattgac gtcaatgggc     3480

gggggtcgtt gggcggtcag ccaggcgggc catttaccgt aagttatgta acgcctgcag     3540

gttaattaag aacatgtgag caaaaggcca gcaaaaggcc aggaaccgta aaaaggccgc     3600

gttgctggcg tttttccata ggctccgccc ccctgacgag catcacaaaa atcgacgctc     3660

aagtcagagg tggcgaaacc cgacaggact ataaagatac caggcgtttc cccctggaag     3720

ctccctcgtg cgctctcctg ttccgaccct gccgcttacc ggatacctgt ccgcctttct     3780

cccttcggga agcgtggcgc tttctcatag ctcacgctgt aggtatctca gttcggtgta     3840

ggtcgttcgc tccaagctgg gctgtgtgca cgaacccccc gttcagcccg accgctgcgc     3900

cttatccggt aactatcgtc ttgagtccaa cccggtaaga cacgacttat cgccactggc     3960

agcagccact ggtaacagga ttagcagagc gaggtatgta ggcggtgcta cagagttctt     4020

gaagtggtgg cctaactacg gctacactag aagaacagta tttggtatct gcgctctgct     4080

gaagccagtt accttcggaa aaagagttgg tagctcttga tccggcaaac aaaccaccgc     4140

tggtagcggt ggtttttttg tttgcaagca gcagattacg cgcagaaaaa aaggatctca     4200

agaagatcct ttgatctttt ctacggggtc tgacgctcag tggaacgaaa actcacgtta     4260

agggattttg gtcatggcta gttaattaac atttaaatca                           4300


<210>  46
<211>  725
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  5' Vector of the construct of SEQ ID NO:45

<400>  46
gcggccgcaa taaaatatct ttattttcat tacatctgtg tgttggtttt ttgtgtgaat       60

cgtaactaac atacgctctc catcaaaaca aaacgaaaca aaacaaacta gcaaaatagg      120

ctgtccccag tgcaagtgca ggtgccagaa catttctcta tcgaaggatc tgcgatcgct      180

ccggtgcccg tcagtgggca gagcgcacat cgcccacagt ccccgagaag ttggggggag      240

gggtcggcaa ttgaacgggt gcctagagaa ggtggcgcgg ggtaaactgg gaaagtgatg      300

tcgtgtactg gctccgcctt tttcccgagg gtgggggaga accgtatata agtgcagtag      360

tcgccgtgaa cgttcttttt cgcaacgggt ttgccgccag aacacagctg aagcttcgag      420

gggctcgcat ctctccttca cgcgcccgcc gccctacctg aggccgccat ccacgccggt      480

tgagtcgcgt tctgccgcct cccgcctgtg gtgcctcctg aactgcgtcc gccgtctagg      540

taagtttaaa gctcaggtcg agaccgggcc tttgtccggc gctcccttgg agcctaccta      600

gactcagccg gctctccacg ctttgcctga ccctgcttgc tcaactctac gtctttgttt      660

cgttttctgt tctgcgccgt tacagatcca agctgtgacc ggcgcctacc tgagatcacc      720

ggcgt                                                                  725


<210>  47
<211>  2819
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3' Vector of the construct of SEQ ID NO:45

<400>  47
tggccagaca tgataagata cattgatgag tttggacaaa ccacaactag aatgcagtga       60

aaaaaatgct ttatttgtga aatttgtgat gctattgctt tatttgtaac cattataagc      120

tgcaataaac aagttaacaa caacaattgc attcatttta tgtttcaggt tcagggggag      180

gtgtgggagg ttttttaaag caagtaaaac ctctacaaat gtggtatgga attctaaaat      240

acagcatagc aaaactttaa cctccaaatc aagcctctac ttgaatcctt ttctgaggga      300

tgaataaggc ataggcatca ggggctgttg ccaatgtgca ttagctgttt gcagcctcac      360

cttctttcat ggagtttaag atatagtgta ttttcccaag gtttgaacta gctcttcatt      420

tctttatgtt ttaaatgcac tgacctccca cattcccttt ttagtaaaat attcagaaat      480

aatttaaata catcattgca atgaaaataa atgtttttta ttaggcagaa tccagatgct      540

caaggccctt cataatatcc cccagtttag tagttggact tagggaacaa aggaaccttt      600

aatagaaatt ggacagcaag aaagcgagct tctagcttta gaagaactca tcaagaagtc      660

tgtagaaggc aattctctgg gagtcagggg ctgcaatgcc atagagcact aggaacctgt      720

ctgcccactc tccccctagc tcttctgcta tgtccctggt tgctagggca atgtcctggt      780

acctgtcagc cactcccagc ctgccacagt ctatgaagcc agagaacctt ccattttcaa      840

ccatgatgtt gggaaggcag gcatccccat gagtcaccac taggtcctca ccatctggca      900

tggatgcctt gagcctggca aatagttcag caggggccag gccctggtgt tcttcatcca      960

agtcatcttg gtccaccagg ccagcctcca tcctggttct ggccctctct atcctgtgct     1020

tggcctggtg gtcaaagggg caggtggctg ggtcaagggt gtggagtctt ctcatggcat     1080

cagccatgat tgacactttc tcagctggag ctaggtgaga ggaaaggagg tcctgcccag     1140

gcacctcacc tagtaggagc cagtcccttc cagcttctgt gaccacatca aggacagctg     1200

cacaggggac cccagttgtt gccaaccagg agagtctggc agcctcatcc tggagctcat     1260

tgagagcccc actgaggtct gtctttacaa aaaggactgg cctgccttgg gctgaaagtc     1320

tgaaaactgc tgcatcagag caaccaatgg tctgctgtgc ccagtcatag ccaaacagtc     1380

tctcaaccca ggcagctgga gaacctgcat gtaggccatc ttgttcaatc atgatggccc     1440

tcctatagtg agtcgtatta tactatgccg atatactatg ccgatgatta attgtcaaaa     1500

cagcgtggat ggcgtctcca gcttatctga cggttcacta aacgagctct gcttatatag     1560

acctcccacc gtacacgcct accgcccatt tgcgtcaatg gggcggagtt gttacgacat     1620

tttggaaagt cccgttgatt tactagtcaa aacaaactcc cattgacgtc aatggggtgg     1680

agacttggaa atccccgtga gtcaaaccgc tatccacgcc cattgatgta ctgccaaaac     1740

cgcatcatca tggtaatagc gatgactaat acgtagatgt actgccaagt aggaaagtcc     1800

cataaggtca tgtactgggc ataatgccag gcgggccatt taccgtcatt gacgtcaata     1860

gggggcgtac ttggcatatg atacacttga tgtactgcca agtgggcagt ttaccgtaaa     1920

tactccaccc attgacgtca atggaaagtc cctattggcg ttactatggg aacatacgtc     1980

attattgacg tcaatgggcg ggggtcgttg ggcggtcagc caggcgggcc atttaccgta     2040

agttatgtaa cgcctgcagg ttaattaaga acatgtgagc aaaaggccag caaaaggcca     2100

ggaaccgtaa aaaggccgcg ttgctggcgt ttttccatag gctccgcccc cctgacgagc     2160

atcacaaaaa tcgacgctca agtcagaggt ggcgaaaccc gacaggacta taaagatacc     2220

aggcgtttcc ccctggaagc tccctcgtgc gctctcctgt tccgaccctg ccgcttaccg     2280

gatacctgtc cgcctttctc ccttcgggaa gcgtggcgct ttctcatagc tcacgctgta     2340

ggtatctcag ttcggtgtag gtcgttcgct ccaagctggg ctgtgtgcac gaaccccccg     2400

ttcagcccga ccgctgcgcc ttatccggta actatcgtct tgagtccaac ccggtaagac     2460

acgacttatc gccactggca gcagccactg gtaacaggat tagcagagcg aggtatgtag     2520

gcggtgctac agagttcttg aagtggtggc ctaactacgg ctacactaga agaacagtat     2580

ttggtatctg cgctctgctg aagccagtta ccttcggaaa aagagttggt agctcttgat     2640

ccggcaaaca aaccaccgct ggtagcggtg gtttttttgt ttgcaagcag cagattacgc     2700

gcagaaaaaa aggatctcaa gaagatcctt tgatcttttc tacggggtct gacgctcagt     2760

ggaacgaaaa ctcacgttaa gggattttgg tcatggctag ttaattaaca tttaaatca      2819


<210>  48
<211>  756
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Insert of the construct of SEQ ID NO:45

<400>  48
gtcgacacca tggagtggag ctgggtgttt ctgttcttcc tgagcgtgac caccggcgtt       60

cattccgaca agacccacac atgtcccccc tgccctgctc ctgaactgct gggaggcccc      120

agcgtgttcc tgtttcctcc caagcccaag gacaccctga tgatcagccg gacccctgaa      180

gtgacctgcg tggtggtgga cgtgtcccac gaggaccccg aggtgaagtt caattggtac      240

gtggacggcg tggaagtcca caacgctaag accaagcccc gggaggaaca gtacaacagc      300

acctaccggg tggtgtccgt gctgaccgtg ctgcaccagg actggctgaa cggcaaggag      360

tacaagtgca aagtgtccaa caaggccctg cccgccccca tcgagaagac catcagcaag      420

gccaagggac agcctaggga gcctcaggtc tacaccctgc ccccttccag ggaggagatg      480

accaagaatc aggtgtccct gacctgcctg gtgaagggct tctaccccag cgacatcgcc      540

gtggagtggg agagcaacgg ccagcctgag aacaactaca agaccacccc tcccgtgctg      600

gatagcgacg gctccttctt cctgaccagc aaactgaccg tggacaagag caggtggcag      660

cagggcaacg tgttctcctg ctccgtgatg cacgaggctc tgcacaaccg gttcacccag      720

aagagcctgt ccctgagccc tggatgatga gctagc                                756


<210>  49
<211>  245
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Translated insert of SEQ ID NO:48

<400>  49

Met Glu Trp Ser Trp Val Phe Leu Phe Phe Leu Ser Val Thr Thr Gly 
1               5                   10                  15      


Val His Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
            20                  25                  30          


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
        35                  40                  45              


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
    50                  55                  60                  


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
65                  70                  75                  80  


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
                85                  90                  95      


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
            100                 105                 110         


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
        115                 120                 125             


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
    130                 135                 140                 


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
145                 150                 155                 160 


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
                165                 170                 175     


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
            180                 185                 190         


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Thr Ser Lys 
        195                 200                 205             


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
    210                 215                 220                 


Ser Val Met His Glu Ala Leu His Asn Arg Phe Thr Gln Lys Ser Leu 
225                 230                 235                 240 


Ser Leu Ser Pro Gly 
                245 


<210>  50
<211>  4110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleic acid sequence of pSELECT-puro Fc/hole (construct JT091)

<400>  50
gcggccgcaa taaaatatct ttattttcat tacatctgtg tgttggtttt ttgtgtgaat       60

cgtaactaac atacgctctc catcaaaaca aaacgaaaca aaacaaacta gcaaaatagg      120

ctgtccccag tgcaagtgca ggtgccagaa catttctcta tcgaaggatc tgcgatcgct      180

ccggtgcccg tcagtgggca gagcgcacat cgcccacagt ccccgagaag ttggggggag      240

gggtcggcaa ttgaacgggt gcctagagaa ggtggcgcgg ggtaaactgg gaaagtgatg      300

tcgtgtactg gctccgcctt tttcccgagg gtgggggaga accgtatata agtgcagtag      360

tcgccgtgaa cgttcttttt cgcaacgggt ttgccgccag aacacagctg aagcttcgag      420

gggctcgcat ctctccttca cgcgcccgcc gccctacctg aggccgccat ccacgccggt      480

tgagtcgcgt tctgccgcct cccgcctgtg gtgcctcctg aactgcgtcc gccgtctagg      540

taagtttaaa gctcaggtcg agaccgggcc tttgtccggc gctcccttgg agcctaccta      600

gactcagccg gctctccacg ctttgcctga ccctgcttgc tcaactctac gtctttgttt      660

cgttttctgt tctgcgccgt tacagatcca agctgtgacc ggcgcctacc tgagatcacc      720

ggcgtgtcga caccatggag tggagctggg tgtttctgtt cttcctgagc gtgaccaccg      780

gcgttcattc cgacaagacc cacacatgtc ccccctgccc tgctcctgaa ctgctgggag      840

gccccagcgt gttcctgttt cctcccaagc ccaaggacac cctgatgatc agccggaccc      900

ctgaagtgac ctgcgtggtg gtggacgtgt cccacgagga ccccgaggtg aagttcaatt      960

ggtacgtgga cggcgtggaa gtccacaacg ctaagaccaa gccccgggag gaacagtaca     1020

acagcaccta ccgggtggtg tccgtgctga ccgtgctgca ccaggactgg ctgaacggca     1080

aggagtacaa gtgcaaagtg tccaacaagg ccctgcccgc ccccatcgag aagaccatca     1140

gcaaggccaa gggacagcct agggagcctc aggtctacac cctgccccct tccagggagg     1200

agatgaccaa gaatcaggtg tccctgacct gcctggtgaa gggcttctac cccagcgaca     1260

tcgccgtgga gtgggagagc aacggccagc ctgagaacaa ctacaagacc acccctcccg     1320

tgctggatag cgacggctcc ttcttcctga ccagcaaact gaccgtggac aagagcaggt     1380

ggcagcaggg caacgtgttc tcctgctccg tgatgcacga ggctctgcac aaccggttca     1440

cccagaagag cctgtccctg agccctggat gatgagctag ctggccagac atgataagat     1500

acattgatga gtttggacaa accacaacta gaatgcagtg aaaaaaatgc tttatttgtg     1560

aaatttgtga tgctattgct ttatttgtaa ccattataag ctgcaataaa caagttaaca     1620

acaacaattg cattcatttt atgtttcagg ttcaggggga ggtgtgggag gttttttaaa     1680

gcaagtaaaa cctctacaaa tgtggtatgg aattctaaaa tacagcatag caaaacttta     1740

acctccaaat caagcctcta cttgaatcct tttctgaggg atgaataagg cataggcatc     1800

aggggctgtt gccaatgtgc attagctgtt tgcagcctca ccttctttca tggagtttaa     1860

gatatagtgt attttcccaa ggtttgaact agctcttcat ttctttatgt tttaaatgca     1920

ctgacctccc acattccctt tttagtaaaa tattcagaaa taatttaaat acatcattgc     1980

aatgaaaata aatgtttttt attaggcaga atccagatgc tcaaggccct tcataatatc     2040

ccccagttta gtagttggac ttagggaaca aaggaacctt taatagaaat tggacagcaa     2100

gaaagcgagc ttctagctca ggtttaagct ccaggcttcc ttgtcatgca ccaagttctt     2160

gggccttctg gaacctcaac atcagctgtc acagtgaatc ccagtctttc ataaaaaggc     2220

aggtttctgg gagcagaagt ttccagaaag gcaggaactc cagccctttc agcagcttca     2280

actccaggca gaacaacagc agatcccaga ccctttccct ggtggtcagg gctcactcca     2340

acagttgcca gaaaccaagc tggctctttt ggcctgtgtg gtgccagcag accttccatt     2400

tgttgttgtg ctgccagcct gcttccagag agctcagcca ttcttggtcc aatttcagca     2460

aaaacagcac cagcttcaac agactcaggt gttgtccaaa ctgcaacagc agctccatca     2520

tctgcaaccc aaacttttcc aatgtccagt cccactctgg tgaggaagag ttcttgcagt     2580

tctgtcaccc tctcaatgtg cctgtcaggg tcaactgtgt gccttgttgc agggtagtct     2640

gcaaaagcag cagccagtgt tctcacagct cttggaacat catctctggt tgccagcctc     2700

actgtgggtt tgtactcagt catggtggcc ctcctatagt gagtcgtatt atactatgcc     2760

gatatactat gccgatgatt aattgtcaaa acagcgtgga tggcgtctcc agcttatctg     2820

acggttcact aaacgagctc tgcttatata gacctcccac cgtacacgcc taccgcccat     2880

ttgcgtcaat ggggcggagt tgttacgaca ttttggaaag tcccgttgat ttactagtca     2940

aaacaaactc ccattgacgt caatggggtg gagacttgga aatccccgtg agtcaaaccg     3000

ctatccacgc ccattgatgt actgccaaaa ccgcatcatc atggtaatag cgatgactaa     3060

tacgtagatg tactgccaag taggaaagtc ccataaggtc atgtactggg cataatgcca     3120

ggcgggccat ttaccgtcat tgacgtcaat agggggcgta cttggcatat gatacacttg     3180

atgtactgcc aagtgggcag tttaccgtaa atactccacc cattgacgtc aatggaaagt     3240

ccctattggc gttactatgg gaacatacgt cattattgac gtcaatgggc gggggtcgtt     3300

gggcggtcag ccaggcgggc catttaccgt aagttatgta acgcctgcag gttaattaag     3360

aacatgtgag caaaaggcca gcaaaaggcc aggaaccgta aaaaggccgc gttgctggcg     3420

tttttccata ggctccgccc ccctgacgag catcacaaaa atcgacgctc aagtcagagg     3480

tggcgaaacc cgacaggact ataaagatac caggcgtttc cccctggaag ctccctcgtg     3540

cgctctcctg ttccgaccct gccgcttacc ggatacctgt ccgcctttct cccttcggga     3600

agcgtggcgc tttctcatag ctcacgctgt aggtatctca gttcggtgta ggtcgttcgc     3660

tccaagctgg gctgtgtgca cgaacccccc gttcagcccg accgctgcgc cttatccggt     3720

aactatcgtc ttgagtccaa cccggtaaga cacgacttat cgccactggc agcagccact     3780

ggtaacagga ttagcagagc gaggtatgta ggcggtgcta cagagttctt gaagtggtgg     3840

cctaactacg gctacactag aagaacagta tttggtatct gcgctctgct gaagccagtt     3900

accttcggaa aaagagttgg tagctcttga tccggcaaac aaaccaccgc tggtagcggt     3960

ggtttttttg tttgcaagca gcagattacg cgcagaaaaa aaggatctca agaagatcct     4020

ttgatctttt ctacggggtc tgacgctcag tggaacgaaa actcacgtta agggattttg     4080

gtcatggcta gttaattaac atttaaatca                                      4110


<210>  51
<211>  725
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  5' Vector of the construct of SEQ ID NO:50

<400>  51
gcggccgcaa taaaatatct ttattttcat tacatctgtg tgttggtttt ttgtgtgaat       60

cgtaactaac atacgctctc catcaaaaca aaacgaaaca aaacaaacta gcaaaatagg      120

ctgtccccag tgcaagtgca ggtgccagaa catttctcta tcgaaggatc tgcgatcgct      180

ccggtgcccg tcagtgggca gagcgcacat cgcccacagt ccccgagaag ttggggggag      240

gggtcggcaa ttgaacgggt gcctagagaa ggtggcgcgg ggtaaactgg gaaagtgatg      300

tcgtgtactg gctccgcctt tttcccgagg gtgggggaga accgtatata agtgcagtag      360

tcgccgtgaa cgttcttttt cgcaacgggt ttgccgccag aacacagctg aagcttcgag      420

gggctcgcat ctctccttca cgcgcccgcc gccctacctg aggccgccat ccacgccggt      480

tgagtcgcgt tctgccgcct cccgcctgtg gtgcctcctg aactgcgtcc gccgtctagg      540

taagtttaaa gctcaggtcg agaccgggcc tttgtccggc gctcccttgg agcctaccta      600

gactcagccg gctctccacg ctttgcctga ccctgcttgc tcaactctac gtctttgttt      660

cgttttctgt tctgcgccgt tacagatcca agctgtgacc ggcgcctacc tgagatcacc      720

ggcgt                                                                  725


<210>  52
<211>  2629
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3' Vector of the construct of SEQ ID NO:50

<400>  52
tggccagaca tgataagata cattgatgag tttggacaaa ccacaactag aatgcagtga       60

aaaaaatgct ttatttgtga aatttgtgat gctattgctt tatttgtaac cattataagc      120

tgcaataaac aagttaacaa caacaattgc attcatttta tgtttcaggt tcagggggag      180

gtgtgggagg ttttttaaag caagtaaaac ctctacaaat gtggtatgga attctaaaat      240

acagcatagc aaaactttaa cctccaaatc aagcctctac ttgaatcctt ttctgaggga      300

tgaataaggc ataggcatca ggggctgttg ccaatgtgca ttagctgttt gcagcctcac      360

cttctttcat ggagtttaag atatagtgta ttttcccaag gtttgaacta gctcttcatt      420

tctttatgtt ttaaatgcac tgacctccca cattcccttt ttagtaaaat attcagaaat      480

aatttaaata catcattgca atgaaaataa atgtttttta ttaggcagaa tccagatgct      540

caaggccctt cataatatcc cccagtttag tagttggact tagggaacaa aggaaccttt      600

aatagaaatt ggacagcaag aaagcgagct tctagctcag gtttaagctc caggcttcct      660

tgtcatgcac caagttcttg ggccttctgg aacctcaaca tcagctgtca cagtgaatcc      720

cagtctttca taaaaaggca ggtttctggg agcagaagtt tccagaaagg caggaactcc      780

agccctttca gcagcttcaa ctccaggcag aacaacagca gatcccagac cctttccctg      840

gtggtcaggg ctcactccaa cagttgccag aaaccaagct ggctcttttg gcctgtgtgg      900

tgccagcaga ccttccattt gttgttgtgc tgccagcctg cttccagaga gctcagccat      960

tcttggtcca atttcagcaa aaacagcacc agcttcaaca gactcaggtg ttgtccaaac     1020

tgcaacagca gctccatcat ctgcaaccca aacttttcca atgtccagtc ccactctggt     1080

gaggaagagt tcttgcagtt ctgtcaccct ctcaatgtgc ctgtcagggt caactgtgtg     1140

ccttgttgca gggtagtctg caaaagcagc agccagtgtt ctcacagctc ttggaacatc     1200

atctctggtt gccagcctca ctgtgggttt gtactcagtc atggtggccc tcctatagtg     1260

agtcgtatta tactatgccg atatactatg ccgatgatta attgtcaaaa cagcgtggat     1320

ggcgtctcca gcttatctga cggttcacta aacgagctct gcttatatag acctcccacc     1380

gtacacgcct accgcccatt tgcgtcaatg gggcggagtt gttacgacat tttggaaagt     1440

cccgttgatt tactagtcaa aacaaactcc cattgacgtc aatggggtgg agacttggaa     1500

atccccgtga gtcaaaccgc tatccacgcc cattgatgta ctgccaaaac cgcatcatca     1560

tggtaatagc gatgactaat acgtagatgt actgccaagt aggaaagtcc cataaggtca     1620

tgtactgggc ataatgccag gcgggccatt taccgtcatt gacgtcaata gggggcgtac     1680

ttggcatatg atacacttga tgtactgcca agtgggcagt ttaccgtaaa tactccaccc     1740

attgacgtca atggaaagtc cctattggcg ttactatggg aacatacgtc attattgacg     1800

tcaatgggcg ggggtcgttg ggcggtcagc caggcgggcc atttaccgta agttatgtaa     1860

cgcctgcagg ttaattaaga acatgtgagc aaaaggccag caaaaggcca ggaaccgtaa     1920

aaaggccgcg ttgctggcgt ttttccatag gctccgcccc cctgacgagc atcacaaaaa     1980

tcgacgctca agtcagaggt ggcgaaaccc gacaggacta taaagatacc aggcgtttcc     2040

ccctggaagc tccctcgtgc gctctcctgt tccgaccctg ccgcttaccg gatacctgtc     2100

cgcctttctc ccttcgggaa gcgtggcgct ttctcatagc tcacgctgta ggtatctcag     2160

ttcggtgtag gtcgttcgct ccaagctggg ctgtgtgcac gaaccccccg ttcagcccga     2220

ccgctgcgcc ttatccggta actatcgtct tgagtccaac ccggtaagac acgacttatc     2280

gccactggca gcagccactg gtaacaggat tagcagagcg aggtatgtag gcggtgctac     2340

agagttcttg aagtggtggc ctaactacgg ctacactaga agaacagtat ttggtatctg     2400

cgctctgctg aagccagtta ccttcggaaa aagagttggt agctcttgat ccggcaaaca     2460

aaccaccgct ggtagcggtg gtttttttgt ttgcaagcag cagattacgc gcagaaaaaa     2520

aggatctcaa gaagatcctt tgatcttttc tacggggtct gacgctcagt ggaacgaaaa     2580

ctcacgttaa gggattttgg tcatggctag ttaattaaca tttaaatca                 2629


<210>  53
<211>  756
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Insert of the construct of SEQ ID NO:50

<400>  53
gtcgacacca tggagtggag ctgggtgttt ctgttcttcc tgagcgtgac caccggcgtt       60

cattccgaca agacccacac atgtcccccc tgccctgctc ctgaactgct gggaggcccc      120

agcgtgttcc tgtttcctcc caagcccaag gacaccctga tgatcagccg gacccctgaa      180

gtgacctgcg tggtggtgga cgtgtcccac gaggaccccg aggtgaagtt caattggtac      240

gtggacggcg tggaagtcca caacgctaag accaagcccc gggaggaaca gtacaacagc      300

acctaccggg tggtgtccgt gctgaccgtg ctgcaccagg actggctgaa cggcaaggag      360

tacaagtgca aagtgtccaa caaggccctg cccgccccca tcgagaagac catcagcaag      420

gccaagggac agcctaggga gcctcaggtc tacaccctgc ccccttccag ggaggagatg      480

accaagaatc aggtgtccct gacctgcctg gtgaagggct tctaccccag cgacatcgcc      540

gtggagtggg agagcaacgg ccagcctgag aacaactaca agaccacccc tcccgtgctg      600

gatagcgacg gctccttctt cctgaccagc aaactgaccg tggacaagag caggtggcag      660

cagggcaacg tgttctcctg ctccgtgatg cacgaggctc tgcacaaccg gttcacccag      720

aagagcctgt ccctgagccc tggatgatga gctagc                                756


<210>  54
<211>  245
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Translated insert of SEQ ID NO:53

<400>  54

Met Glu Trp Ser Trp Val Phe Leu Phe Phe Leu Ser Val Thr Thr Gly 
1               5                   10                  15      


Val His Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
            20                  25                  30          


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
        35                  40                  45              


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
    50                  55                  60                  


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
65                  70                  75                  80  


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
                85                  90                  95      


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
            100                 105                 110         


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
        115                 120                 125             


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
    130                 135                 140                 


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
145                 150                 155                 160 


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
                165                 170                 175     


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
            180                 185                 190         


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Thr Ser Lys 
        195                 200                 205             


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
    210                 215                 220                 


Ser Val Met His Glu Ala Leu His Asn Arg Phe Thr Gln Lys Ser Leu 
225                 230                 235                 240 


Ser Leu Ser Pro Gly 
                245 


<210>  55
<211>  5593
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleic acid sequence of pSELECT-puro FVII-Fc/hole (construct 
       JT092)

<400>  55
gcggccgcaa taaaatatct ttattttcat tacatctgtg tgttggtttt ttgtgtgaat       60

cgtaactaac atacgctctc catcaaaaca aaacgaaaca aaacaaacta gcaaaatagg      120

ctgtccccag tgcaagtgca ggtgccagaa catttctcta tcgaaggatc tgcgatcgct      180

ccggtgcccg tcagtgggca gagcgcacat cgcccacagt ccccgagaag ttggggggag      240

gggtcggcaa ttgaacgggt gcctagagaa ggtggcgcgg ggtaaactgg gaaagtgatg      300

tcgtgtactg gctccgcctt tttcccgagg gtgggggaga accgtatata agtgcagtag      360

tcgccgtgaa cgttcttttt cgcaacgggt ttgccgccag aacacagctg aagcttcgag      420

gggctcgcat ctctccttca cgcgcccgcc gccctacctg aggccgccat ccacgccggt      480

tgagtcgcgt tctgccgcct cccgcctgtg gtgcctcctg aactgcgtcc gccgtctagg      540

taagtttaaa gctcaggtcg agaccgggcc tttgtccggc gctcccttgg agcctaccta      600

gactcagccg gctctccacg ctttgcctga ccctgcttgc tcaactctac gtctttgttt      660

cgttttctgt tctgcgccgt tacagatcca agctgtgacc ggcgcctacc tgagatcacc      720

ggcgtgtcga cggtaccacc atggtcagcc aggccctcag gctgctctgt ctcctgctgg      780

gcctccaggg ctgtctggct gccgtcttcg tgacccagga ggaggctcac ggcgtgctcc      840

acaggaggag aagagctaac gctttcctcg aagagctgag gcccggcagc ctggaaaggg      900

agtgcaaaga ggagcagtgc agcttcgaag aagccaggga aattttcaag gacgccgaga      960

ggaccaagct gttctggatc tcctatagcg acggcgatca gtgcgcttcc agcccctgcc     1020

agaacggagg ctcctgcaag gatcagctgc agtcctacat ttgcttctgt ctgcccgcct     1080

ttgagggcag aaactgtgag acccacaagg atgaccagct gatttgtgtg aatgagaacg     1140

gcggatgcga acagtactgc tccgaccata ccggaacaaa gaggtcctgc agatgccatg     1200

agggctacag cctgctggcc gatggagtga gctgcacccc caccgtggaa tacccctgcg     1260

gcaaaatccc catcctggag aagaggaatg ccagcaaacc ccagggcagg attgtgggcg     1320

gaaaggtgtg ccccaaagga gagtgtcctt ggcaggtgct gctgctcgtg aacggagccc     1380

agctgtgcgg cggcacactc atcaatacca tctgggtggt cagcgccgcc cactgctttg     1440

acaagatcaa gaactggagg aacctcatcg ccgtgctggg agagcacgat ctgagcgagc     1500

atgacggcga cgaacagtcc aggagagtgg cccaggtgat catccctagc acatatgtcc     1560

ccggcaccac caaccatgat atcgccctcc tcaggctgca tcagcccgtg gtgctgacag     1620

accacgtggt gcctctctgc ctgcccgaga ggaccttcag cgagaggacc ctggccttcg     1680

tgagattcag cctggtgagc ggatggggcc agctcctgga tagaggcgcc acagccctgg     1740

agctgatggt gctgaacgtg cctagactga tgacccaaga ttgcctccag cagagcagga     1800

aggtgggaga ctcccccaat atcacagagt atatgttttg cgccggctac agcgatggtt     1860

ctaaagattc ctgtgctggc gacagcggag gcccccacgc tacccactac agaggcacat     1920

ggtatttaac cggaatcgtg tcctggggac aaggctgcgc caccgtgggc catttcggcg     1980

tgtacaccag ggtcagccag tacatcgaat ggctgcagaa actcatgagg tccgagccta     2040

gacccggcgt cctgctgaga gcccctttcc ctgataaaac acacacctgt cccccttgtc     2100

ctgctcctga gctcctgggc ggaccttccg tgttcctgtt tcctcccaaa cccaaggaca     2160

ccctgatgat ctccaggacc cccgaggtga catgcgtcgt ggtggacgtg agccacgagg     2220

accccgaggt caagttcaac tggtacgtcg atggcgtgga ggtccacaat gccaagacca     2280

agcccaggga ggagcaatat aactccacct acagggtggt cagcgtgctc acagtgctgc     2340

accaggattg gctgaacggc aaagagtaca agtgcaaggt cagcaacaaa gccctgcctg     2400

cccccatcga gaaaaccatc tccaaggcta agggccagcc cagggagcct caggtgtaca     2460

cactgcctcc tagcagagag gagatgacca agaaccaggt cagcctctac tgcctggtca     2520

aaggcttcta cccctccgat attgctgtgg aatgggagtc caacggccaa cccgagaaca     2580

actacaagac cacaccccct gtgctggaca gcgacggttc ttttttcctg tacagcaagc     2640

tgaccgtcga taagagcaga tggcagcagg gaaacgtgtt cagctgttcc gtcatgcacg     2700

aggccctgca caaccactat acccagaaaa gcctctccct gagccctggc tgatgaagat     2760

ctggatccgc tagctggcca gacatgataa gatacattga tgagtttgga caaaccacaa     2820

ctagaatgca gtgaaaaaaa tgctttattt gtgaaatttg tgatgctatt gctttatttg     2880

taaccattat aagctgcaat aaacaagtta acaacaacaa ttgcattcat tttatgtttc     2940

aggttcaggg ggaggtgtgg gaggtttttt aaagcaagta aaacctctac aaatgtggta     3000

tggaattcta aaatacagca tagcaaaact ttaacctcca aatcaagcct ctacttgaat     3060

ccttttctga gggatgaata aggcataggc atcaggggct gttgccaatg tgcattagct     3120

gtttgcagcc tcaccttctt tcatggagtt taagatatag tgtattttcc caaggtttga     3180

actagctctt catttcttta tgttttaaat gcactgacct cccacattcc ctttttagta     3240

aaatattcag aaataattta aatacatcat tgcaatgaaa ataaatgttt tttattaggc     3300

agaatccaga tgctcaaggc ccttcataat atcccccagt ttagtagttg gacttaggga     3360

acaaaggaac ctttaataga aattggacag caagaaagcg agcttctagc tttagaagaa     3420

ctcatcaaga agtctgtaga aggcaattct ctgggagtca ggggctgcaa tgccatagag     3480

cactaggaac ctgtctgccc actctccccc tagctcttct gctatgtccc tggttgctag     3540

ggcaatgtcc tggtacctgt cagccactcc cagcctgcca cagtctatga agccagagaa     3600

ccttccattt tcaaccatga tgttgggaag gcaggcatcc ccatgagtca ccactaggtc     3660

ctcaccatct ggcatggatg ccttgagcct ggcaaatagt tcagcagggg ccaggccctg     3720

gtgttcttca tccaagtcat cttggtccac caggccagcc tccatcctgg ttctggccct     3780

ctctatcctg tgcttggcct ggtggtcaaa ggggcaggtg gctgggtcaa gggtgtggag     3840

tcttctcatg gcatcagcca tgattgacac tttctcagct ggagctaggt gagaggaaag     3900

gaggtcctgc ccaggcacct cacctagtag gagccagtcc cttccagctt ctgtgaccac     3960

atcaaggaca gctgcacagg ggaccccagt tgttgccaac caggagagtc tggcagcctc     4020

atcctggagc tcattgagag ccccactgag gtctgtcttt acaaaaagga ctggcctgcc     4080

ttgggctgaa agtctgaaaa ctgctgcatc agagcaacca atggtctgct gtgcccagtc     4140

atagccaaac agtctctcaa cccaggcagc tggagaacct gcatgtaggc catcttgttc     4200

aatcatgatg gccctcctat agtgagtcgt attatactat gccgatatac tatgccgatg     4260

attaattgtc aaaacagcgt ggatggcgtc tccagcttat ctgacggttc actaaacgag     4320

ctctgcttat atagacctcc caccgtacac gcctaccgcc catttgcgtc aatggggcgg     4380

agttgttacg acattttgga aagtcccgtt gatttactag tcaaaacaaa ctcccattga     4440

cgtcaatggg gtggagactt ggaaatcccc gtgagtcaaa ccgctatcca cgcccattga     4500

tgtactgcca aaaccgcatc atcatggtaa tagcgatgac taatacgtag atgtactgcc     4560

aagtaggaaa gtcccataag gtcatgtact gggcataatg ccaggcgggc catttaccgt     4620

cattgacgtc aatagggggc gtacttggca tatgatacac ttgatgtact gccaagtggg     4680

cagtttaccg taaatactcc acccattgac gtcaatggaa agtccctatt ggcgttacta     4740

tgggaacata cgtcattatt gacgtcaatg ggcgggggtc gttgggcggt cagccaggcg     4800

ggccatttac cgtaagttat gtaacgcctg caggttaatt aagaacatgt gagcaaaagg     4860

ccagcaaaag gccaggaacc gtaaaaaggc cgcgttgctg gcgtttttcc ataggctccg     4920

cccccctgac gagcatcaca aaaatcgacg ctcaagtcag aggtggcgaa acccgacagg     4980

actataaaga taccaggcgt ttccccctgg aagctccctc gtgcgctctc ctgttccgac     5040

cctgccgctt accggatacc tgtccgcctt tctcccttcg ggaagcgtgg cgctttctca     5100

tagctcacgc tgtaggtatc tcagttcggt gtaggtcgtt cgctccaagc tgggctgtgt     5160

gcacgaaccc cccgttcagc ccgaccgctg cgccttatcc ggtaactatc gtcttgagtc     5220

caacccggta agacacgact tatcgccact ggcagcagcc actggtaaca ggattagcag     5280

agcgaggtat gtaggcggtg ctacagagtt cttgaagtgg tggcctaact acggctacac     5340

tagaagaaca gtatttggta tctgcgctct gctgaagcca gttaccttcg gaaaaagagt     5400

tggtagctct tgatccggca aacaaaccac cgctggtagc ggtggttttt ttgtttgcaa     5460

gcagcagatt acgcgcagaa aaaaaggatc tcaagaagat cctttgatct tttctacggg     5520

gtctgacgct cagtggaacg aaaactcacg ttaagggatt ttggtcatgg ctagttaatt     5580

aacatttaaa tca                                                        5593


<210>  56
<211>  725
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  5' Vector of the construct of SEQ ID NO:55

<400>  56
gcggccgcaa taaaatatct ttattttcat tacatctgtg tgttggtttt ttgtgtgaat       60

cgtaactaac atacgctctc catcaaaaca aaacgaaaca aaacaaacta gcaaaatagg      120

ctgtccccag tgcaagtgca ggtgccagaa catttctcta tcgaaggatc tgcgatcgct      180

ccggtgcccg tcagtgggca gagcgcacat cgcccacagt ccccgagaag ttggggggag      240

gggtcggcaa ttgaacgggt gcctagagaa ggtggcgcgg ggtaaactgg gaaagtgatg      300

tcgtgtactg gctccgcctt tttcccgagg gtgggggaga accgtatata agtgcagtag      360

tcgccgtgaa cgttcttttt cgcaacgggt ttgccgccag aacacagctg aagcttcgag      420

gggctcgcat ctctccttca cgcgcccgcc gccctacctg aggccgccat ccacgccggt      480

tgagtcgcgt tctgccgcct cccgcctgtg gtgcctcctg aactgcgtcc gccgtctagg      540

taagtttaaa gctcaggtcg agaccgggcc tttgtccggc gctcccttgg agcctaccta      600

gactcagccg gctctccacg ctttgcctga ccctgcttgc tcaactctac gtctttgttt      660

cgttttctgt tctgcgccgt tacagatcca agctgtgacc ggcgcctacc tgagatcacc      720

ggcgt                                                                  725


<210>  57
<211>  2819
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3' Vector of the construct of SEQ ID NO:55

<400>  57
tggccagaca tgataagata cattgatgag tttggacaaa ccacaactag aatgcagtga       60

aaaaaatgct ttatttgtga aatttgtgat gctattgctt tatttgtaac cattataagc      120

tgcaataaac aagttaacaa caacaattgc attcatttta tgtttcaggt tcagggggag      180

gtgtgggagg ttttttaaag caagtaaaac ctctacaaat gtggtatgga attctaaaat      240

acagcatagc aaaactttaa cctccaaatc aagcctctac ttgaatcctt ttctgaggga      300

tgaataaggc ataggcatca ggggctgttg ccaatgtgca ttagctgttt gcagcctcac      360

cttctttcat ggagtttaag atatagtgta ttttcccaag gtttgaacta gctcttcatt      420

tctttatgtt ttaaatgcac tgacctccca cattcccttt ttagtaaaat attcagaaat      480

aatttaaata catcattgca atgaaaataa atgtttttta ttaggcagaa tccagatgct      540

caaggccctt cataatatcc cccagtttag tagttggact tagggaacaa aggaaccttt      600

aatagaaatt ggacagcaag aaagcgagct tctagcttta gaagaactca tcaagaagtc      660

tgtagaaggc aattctctgg gagtcagggg ctgcaatgcc atagagcact aggaacctgt      720

ctgcccactc tccccctagc tcttctgcta tgtccctggt tgctagggca atgtcctggt      780

acctgtcagc cactcccagc ctgccacagt ctatgaagcc agagaacctt ccattttcaa      840

ccatgatgtt gggaaggcag gcatccccat gagtcaccac taggtcctca ccatctggca      900

tggatgcctt gagcctggca aatagttcag caggggccag gccctggtgt tcttcatcca      960

agtcatcttg gtccaccagg ccagcctcca tcctggttct ggccctctct atcctgtgct     1020

tggcctggtg gtcaaagggg caggtggctg ggtcaagggt gtggagtctt ctcatggcat     1080

cagccatgat tgacactttc tcagctggag ctaggtgaga ggaaaggagg tcctgcccag     1140

gcacctcacc tagtaggagc cagtcccttc cagcttctgt gaccacatca aggacagctg     1200

cacaggggac cccagttgtt gccaaccagg agagtctggc agcctcatcc tggagctcat     1260

tgagagcccc actgaggtct gtctttacaa aaaggactgg cctgccttgg gctgaaagtc     1320

tgaaaactgc tgcatcagag caaccaatgg tctgctgtgc ccagtcatag ccaaacagtc     1380

tctcaaccca ggcagctgga gaacctgcat gtaggccatc ttgttcaatc atgatggccc     1440

tcctatagtg agtcgtatta tactatgccg atatactatg ccgatgatta attgtcaaaa     1500

cagcgtggat ggcgtctcca gcttatctga cggttcacta aacgagctct gcttatatag     1560

acctcccacc gtacacgcct accgcccatt tgcgtcaatg gggcggagtt gttacgacat     1620

tttggaaagt cccgttgatt tactagtcaa aacaaactcc cattgacgtc aatggggtgg     1680

agacttggaa atccccgtga gtcaaaccgc tatccacgcc cattgatgta ctgccaaaac     1740

cgcatcatca tggtaatagc gatgactaat acgtagatgt actgccaagt aggaaagtcc     1800

cataaggtca tgtactgggc ataatgccag gcgggccatt taccgtcatt gacgtcaata     1860

gggggcgtac ttggcatatg atacacttga tgtactgcca agtgggcagt ttaccgtaaa     1920

tactccaccc attgacgtca atggaaagtc cctattggcg ttactatggg aacatacgtc     1980

attattgacg tcaatgggcg ggggtcgttg ggcggtcagc caggcgggcc atttaccgta     2040

agttatgtaa cgcctgcagg ttaattaaga acatgtgagc aaaaggccag caaaaggcca     2100

ggaaccgtaa aaaggccgcg ttgctggcgt ttttccatag gctccgcccc cctgacgagc     2160

atcacaaaaa tcgacgctca agtcagaggt ggcgaaaccc gacaggacta taaagatacc     2220

aggcgtttcc ccctggaagc tccctcgtgc gctctcctgt tccgaccctg ccgcttaccg     2280

gatacctgtc cgcctttctc ccttcgggaa gcgtggcgct ttctcatagc tcacgctgta     2340

ggtatctcag ttcggtgtag gtcgttcgct ccaagctggg ctgtgtgcac gaaccccccg     2400

ttcagcccga ccgctgcgcc ttatccggta actatcgtct tgagtccaac ccggtaagac     2460

acgacttatc gccactggca gcagccactg gtaacaggat tagcagagcg aggtatgtag     2520

gcggtgctac agagttcttg aagtggtggc ctaactacgg ctacactaga agaacagtat     2580

ttggtatctg cgctctgctg aagccagtta ccttcggaaa aagagttggt agctcttgat     2640

ccggcaaaca aaccaccgct ggtagcggtg gtttttttgt ttgcaagcag cagattacgc     2700

gcagaaaaaa aggatctcaa gaagatcctt tgatcttttc tacggggtct gacgctcagt     2760

ggaacgaaaa ctcacgttaa gggattttgg tcatggctag ttaattaaca tttaaatca      2819


<210>  58
<211>  2049
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Insert of the construct of SEQ ID NO:55

<400>  58
gtcgacggta ccaccatggt cagccaggcc ctcaggctgc tctgtctcct gctgggcctc       60

cagggctgtc tggctgccgt cttcgtgacc caggaggagg ctcacggcgt gctccacagg      120

aggagaagag ctaacgcttt cctcgaagag ctgaggcccg gcagcctgga aagggagtgc      180

aaagaggagc agtgcagctt cgaagaagcc agggaaattt tcaaggacgc cgagaggacc      240

aagctgttct ggatctccta tagcgacggc gatcagtgcg cttccagccc ctgccagaac      300

ggaggctcct gcaaggatca gctgcagtcc tacatttgct tctgtctgcc cgcctttgag      360

ggcagaaact gtgagaccca caaggatgac cagctgattt gtgtgaatga gaacggcgga      420

tgcgaacagt actgctccga ccataccgga acaaagaggt cctgcagatg ccatgagggc      480

tacagcctgc tggccgatgg agtgagctgc acccccaccg tggaataccc ctgcggcaaa      540

atccccatcc tggagaagag gaatgccagc aaaccccagg gcaggattgt gggcggaaag      600

gtgtgcccca aaggagagtg tccttggcag gtgctgctgc tcgtgaacgg agcccagctg      660

tgcggcggca cactcatcaa taccatctgg gtggtcagcg ccgcccactg ctttgacaag      720

atcaagaact ggaggaacct catcgccgtg ctgggagagc acgatctgag cgagcatgac      780

ggcgacgaac agtccaggag agtggcccag gtgatcatcc ctagcacata tgtccccggc      840

accaccaacc atgatatcgc cctcctcagg ctgcatcagc ccgtggtgct gacagaccac      900

gtggtgcctc tctgcctgcc cgagaggacc ttcagcgaga ggaccctggc cttcgtgaga      960

ttcagcctgg tgagcggatg gggccagctc ctggatagag gcgccacagc cctggagctg     1020

atggtgctga acgtgcctag actgatgacc caagattgcc tccagcagag caggaaggtg     1080

ggagactccc ccaatatcac agagtatatg ttttgcgccg gctacagcga tggttctaaa     1140

gattcctgtg ctggcgacag cggaggcccc cacgctaccc actacagagg cacatggtat     1200

ttaaccggaa tcgtgtcctg gggacaaggc tgcgccaccg tgggccattt cggcgtgtac     1260

accagggtca gccagtacat cgaatggctg cagaaactca tgaggtccga gcctagaccc     1320

ggcgtcctgc tgagagcccc tttccctgat aaaacacaca cctgtccccc ttgtcctgct     1380

cctgagctcc tgggcggacc ttccgtgttc ctgtttcctc ccaaacccaa ggacaccctg     1440

atgatctcca ggacccccga ggtgacatgc gtcgtggtgg acgtgagcca cgaggacccc     1500

gaggtcaagt tcaactggta cgtcgatggc gtggaggtcc acaatgccaa gaccaagccc     1560

agggaggagc aatataactc cacctacagg gtggtcagcg tgctcacagt gctgcaccag     1620

gattggctga acggcaaaga gtacaagtgc aaggtcagca acaaagccct gcctgccccc     1680

atcgagaaaa ccatctccaa ggctaagggc cagcccaggg agcctcaggt gtacacactg     1740

cctcctagca gagaggagat gaccaagaac caggtcagcc tctactgcct ggtcaaaggc     1800

ttctacccct ccgatattgc tgtggaatgg gagtccaacg gccaacccga gaacaactac     1860

aagaccacac cccctgtgct ggacagcgac ggttcttttt tcctgtacag caagctgacc     1920

gtcgataaga gcagatggca gcagggaaac gtgttcagct gttccgtcat gcacgaggcc     1980

ctgcacaacc actataccca gaaaagcctc tccctgagcc ctggctgatg aagatctgga     2040

tccgctagc                                                             2049


<210>  59
<211>  670
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Translated insert of SEQ ID NO:58

<400>  59

Met Val Ser Gln Ala Leu Arg Leu Leu Cys Leu Leu Leu Gly Leu Gln 
1               5                   10                  15      


Gly Cys Leu Ala Ala Val Phe Val Thr Gln Glu Glu Ala His Gly Val 
            20                  25                  30          


Leu His Arg Arg Arg Arg Ala Asn Ala Phe Leu Glu Glu Leu Arg Pro 
        35                  40                  45              


Gly Ser Leu Glu Arg Glu Cys Lys Glu Glu Gln Cys Ser Phe Glu Glu 
    50                  55                  60                  


Ala Arg Glu Ile Phe Lys Asp Ala Glu Arg Thr Lys Leu Phe Trp Ile 
65                  70                  75                  80  


Ser Tyr Ser Asp Gly Asp Gln Cys Ala Ser Ser Pro Cys Gln Asn Gly 
                85                  90                  95      


Gly Ser Cys Lys Asp Gln Leu Gln Ser Tyr Ile Cys Phe Cys Leu Pro 
            100                 105                 110         


Ala Phe Glu Gly Arg Asn Cys Glu Thr His Lys Asp Asp Gln Leu Ile 
        115                 120                 125             


Cys Val Asn Glu Asn Gly Gly Cys Glu Gln Tyr Cys Ser Asp His Thr 
    130                 135                 140                 


Gly Thr Lys Arg Ser Cys Arg Cys His Glu Gly Tyr Ser Leu Leu Ala 
145                 150                 155                 160 


Asp Gly Val Ser Cys Thr Pro Thr Val Glu Tyr Pro Cys Gly Lys Ile 
                165                 170                 175     


Pro Ile Leu Glu Lys Arg Asn Ala Ser Lys Pro Gln Gly Arg Ile Val 
            180                 185                 190         


Gly Gly Lys Val Cys Pro Lys Gly Glu Cys Pro Trp Gln Val Leu Leu 
        195                 200                 205             


Leu Val Asn Gly Ala Gln Leu Cys Gly Gly Thr Leu Ile Asn Thr Ile 
    210                 215                 220                 


Trp Val Val Ser Ala Ala His Cys Phe Asp Lys Ile Lys Asn Trp Arg 
225                 230                 235                 240 


Asn Leu Ile Ala Val Leu Gly Glu His Asp Leu Ser Glu His Asp Gly 
                245                 250                 255     


Asp Glu Gln Ser Arg Arg Val Ala Gln Val Ile Ile Pro Ser Thr Tyr 
            260                 265                 270         


Val Pro Gly Thr Thr Asn His Asp Ile Ala Leu Leu Arg Leu His Gln 
        275                 280                 285             


Pro Val Val Leu Thr Asp His Val Val Pro Leu Cys Leu Pro Glu Arg 
    290                 295                 300                 


Thr Phe Ser Glu Arg Thr Leu Ala Phe Val Arg Phe Ser Leu Val Ser 
305                 310                 315                 320 


Gly Trp Gly Gln Leu Leu Asp Arg Gly Ala Thr Ala Leu Glu Leu Met 
                325                 330                 335     


Val Leu Asn Val Pro Arg Leu Met Thr Gln Asp Cys Leu Gln Gln Ser 
            340                 345                 350         


Arg Lys Val Gly Asp Ser Pro Asn Ile Thr Glu Tyr Met Phe Cys Ala 
        355                 360                 365             


Gly Tyr Ser Asp Gly Ser Lys Asp Ser Cys Ala Gly Asp Ser Gly Gly 
    370                 375                 380                 


Pro His Ala Thr His Tyr Arg Gly Thr Trp Tyr Leu Thr Gly Ile Val 
385                 390                 395                 400 


Ser Trp Gly Gln Gly Cys Ala Thr Val Gly His Phe Gly Val Tyr Thr 
                405                 410                 415     


Arg Val Ser Gln Tyr Ile Glu Trp Leu Gln Lys Leu Met Arg Ser Glu 
            420                 425                 430         


Pro Arg Pro Gly Val Leu Leu Arg Ala Pro Phe Pro Asp Lys Thr His 
        435                 440                 445             


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
    450                 455                 460                 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
465                 470                 475                 480 


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
                485                 490                 495     


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
            500                 505                 510         


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
        515                 520                 525             


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
    530                 535                 540                 


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
545                 550                 555                 560 


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
                565                 570                 575     


Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Tyr Cys Leu 
            580                 585                 590         


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
        595                 600                 605             


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
    610                 615                 620                 


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
625                 630                 635                 640 


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
                645                 650                 655     


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
            660                 665                 670 


